-- dump date 20140619_080803 -- class Genbank::CDS -- table cds -- table main -- field 1 id -- field 2 GI -- field 3 GeneID -- field 4 chrom_position -- field 5 chromosome -- field 6 codon_start -- field 7 contig -- field 8 description -- field 9 end_pos -- field 10 gene -- field 11 gene_id -- field 12 name -- field 13 organism -- field 14 product -- field 15 protein_id -- field 16 start_pos -- field 17 strand -- field 18 taxid -- field 19 type -- header -- id GI GeneID chrom_position chromosome codon_start contig description end_pos gene gene_id name organism product protein_id start_pos strand taxid type YP_002401144.1 218693477 7149501 203..268 1 NC_011748.1 involved in threonine biosynthesis; controls the expression of the thrLABC operon; thr operon leader peptide 268 thrL 7149501 thrL Escherichia coli 55989 thr operon leader peptide YP_002401144.1 203 D 585055 CDS YP_002401145.1 218693478 7147797 349..2811 1 NC_011748.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 2811 thrA 7147797 thrA Escherichia coli 55989 bifunctional aspartokinase I/homoserine dehydrogenase I YP_002401145.1 349 D 585055 CDS YP_002401146.1 218693479 7147794 2813..3745 1 NC_011748.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 3745 thrB 7147794 thrB Escherichia coli 55989 homoserine kinase YP_002401146.1 2813 D 585055 CDS YP_002401147.1 218693480 7147795 3746..5032 1 NC_011748.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 5032 thrC 7147795 thrC Escherichia coli 55989 threonine synthase YP_002401147.1 3746 D 585055 CDS YP_002401148.1 218693481 7147796 5246..5542 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5542 yaaX 7147796 yaaX Escherichia coli 55989 hypothetical protein YP_002401148.1 5246 D 585055 CDS YP_002401149.1 218693482 7148007 complement(5695..6471) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 6471 yaaA 7148007 yaaA Escherichia coli 55989 hypothetical protein YP_002401149.1 5695 R 585055 CDS YP_002401150.1 218693483 7148002 complement(6541..7971) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; amino acid sodium/proton transporter 7971 yaaJ 7148002 yaaJ Escherichia coli 55989 amino acid sodium/proton transporter YP_002401150.1 6541 R 585055 CDS YP_002401151.1 218693484 7148005 8250..9203 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 92334977, 11298760, 7592346, 8805555, 9007983, 9298646; Product type e : enzyme; transaldolase B 9203 talB 7148005 talB Escherichia coli 55989 transaldolase B YP_002401151.1 8250 D 585055 CDS YP_002401152.1 218693485 7147748 9318..9905 1 NC_011748.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9905 mogA 7147748 mogA Escherichia coli 55989 molybdenum cofactor biosynthesis protein MogA YP_002401152.1 9318 D 585055 CDS YP_002401153.1 218693486 7146886 complement(9940..10506) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 10506 yaaH 7146886 yaaH Escherichia coli 55989 hypothetical protein YP_002401153.1 9940 R 585055 CDS YP_002401154.1 218693487 7148003 complement(10655..11368) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8478327; Product type r : regulator; hypothetical protein 11368 htpY 7148003 htpY Escherichia coli 55989 hypothetical protein YP_002401154.1 10655 R 585055 CDS YP_002401155.1 218693488 7146475 complement(11394..11798) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 11798 yaaI 7146475 yaaI Escherichia coli 55989 hypothetical protein YP_002401155.1 11394 R 585055 CDS YP_002401156.1 218693489 7148004 12175..14091 1 NC_011748.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 14091 dnaK 7148004 dnaK Escherichia coli 55989 molecular chaperone DnaK YP_002401156.1 12175 D 585055 CDS YP_002401157.1 218693490 7147831 14180..15310 1 NC_011748.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 15310 dnaJ 7147831 dnaJ Escherichia coli 55989 molecular chaperone DnaJ YP_002401157.1 14180 D 585055 CDS YP_002401158.1 218693491 7147677 16152..17318 1 NC_011748.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 17318 nhaA 7147677 nhaA Escherichia coli 55989 pH-dependent sodium/proton antiporter YP_002401158.1 16152 D 585055 CDS YP_002401159.1 218693492 7146991 17378..18283 1 NC_011748.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 18283 nhaR 7146991 nhaR Escherichia coli 55989 transcriptional activator NhaR YP_002401159.1 17378 D 585055 CDS YP_002401160.1 218693493 7146993 complement(18322..19281) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 19281 7146993 EC55989_0018 Escherichia coli 55989 hypothetical protein YP_002401160.1 18322 R 585055 CDS YP_002401161.1 218693494 7144359 complement(22776..23039) 1 NC_011748.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 23039 rpsT 7144359 rpsT Escherichia coli 55989 30S ribosomal protein S20 YP_002401161.1 22776 R 585055 CDS YP_002401162.1 218693495 7147524 23142..23360 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 23360 yaaY 7147524 yaaY Escherichia coli 55989 hypothetical protein YP_002401162.1 23142 D 585055 CDS YP_002401163.1 218693496 7148008 23368..24309 1 NC_011748.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 24309 ribF 7148008 ribF Escherichia coli 55989 bifunctional riboflavin kinase/FMN adenylyltransferase YP_002401163.1 23368 D 585055 CDS YP_002401164.1 218693497 7147414 24352..27168 1 NC_011748.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 27168 ileS 7147414 ileS Escherichia coli 55989 isoleucyl-tRNA synthetase YP_002401164.1 24352 D 585055 CDS YP_002401165.1 218693498 7146548 27168..27662 1 NC_011748.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 27662 lspA 7146548 lspA Escherichia coli 55989 lipoprotein signal peptidase YP_002401165.1 27168 D 585055 CDS YP_002401166.1 218693499 7146745 27750..28199 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97332650, 2011499; Product type e : enzyme; FKBP-type peptidylprolyl isomerase 28199 fkpB 7146745 fkpB Escherichia coli 55989 FKBP-type peptidylprolyl isomerase YP_002401166.1 27750 D 585055 CDS YP_002401167.1 218693500 7146121 28201..29151 1 NC_011748.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 29151 ispH 7146121 ispH Escherichia coli 55989 4-hydroxy-3-methylbut-2-enyl diphosphate reductase YP_002401167.1 28201 D 585055 CDS YP_002401168.1 218693501 7146631 29217..30131 1 NC_011748.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 30131 rihC 7146631 rihC Escherichia coli 55989 ribonucleoside hydrolase RihC YP_002401168.1 29217 D 585055 CDS YP_002401169.1 218693502 7147417 30298..31119 1 NC_011748.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 31119 dapB 7147417 dapB Escherichia coli 55989 dihydrodipicolinate reductase YP_002401169.1 30298 D 585055 CDS YP_002401170.1 218693503 7145850 31575..32723 1 NC_011748.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 32723 carA 7145850 carA Escherichia coli 55989 carbamoyl phosphate synthase small subunit YP_002401170.1 31575 D 585055 CDS YP_002401171.1 218693504 7145664 32741..35962 1 NC_011748.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 35962 carB 7145664 carB Escherichia coli 55989 carbamoyl phosphate synthase large subunit YP_002401171.1 32741 D 585055 CDS YP_002401172.1 218693505 7145665 complement(35970..36188) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7815937, 6308632; hypothetical protein 36188 7145665 EC55989_0033 Escherichia coli 55989 hypothetical protein YP_002401172.1 35970 R 585055 CDS YP_002401173.1 218693506 7144360 36223..36618 1 NC_011748.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 36618 caiF 7144360 caiF Escherichia coli 55989 DNA-binding transcriptional activator CaiF YP_002401173.1 36223 D 585055 CDS YP_002401174.1 218693507 7145661 complement(36704..37294) 1 NC_011748.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE 37294 caiE 7145661 caiE Escherichia coli 55989 carnitine operon protein CaiE YP_002401174.1 36704 R 585055 CDS YP_002401175.2 229598869 7145660 complement(37300..38085) 1 NC_011748.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase 38085 caiD 7145660 caiD Escherichia coli 55989 carnitinyl-CoA dehydratase YP_002401175.2 37300 R 585055 CDS YP_002401176.1 218693509 7145659 complement(38194..39762) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15731894, 97189569, 7815937; Product type e : enzyme; crotonobetaine/carnitine-CoA ligase 39762 caiC 7145659 caiC Escherichia coli 55989 crotonobetaine/carnitine-CoA ligase YP_002401176.1 38194 R 585055 CDS YP_002401177.1 218693510 7145658 complement(39821..41038) 1 NC_011748.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase 41038 caiB 7145658 caiB Escherichia coli 55989 crotonobetainyl-CoA:carnitine CoA-transferase YP_002401177.1 39821 R 585055 CDS YP_002401178.1 218693511 7145657 complement(41167..42309) 1 NC_011748.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase 42309 caiA 7145657 caiA Escherichia coli 55989 crotonobetainyl-CoA dehydrogenase YP_002401178.1 41167 R 585055 CDS YP_002401179.1 218693512 7145656 complement(42340..43854) 1 NC_011748.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter 43854 caiT 7145656 caiT Escherichia coli 55989 L-carnitine/gamma-butyrobetaine antiporter YP_002401179.1 42340 R 585055 CDS YP_002401180.1 218693513 7145662 44328..45098 1 NC_011748.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; electron transfer flavoprotein FixA 45098 fixA 7145662 fixA Escherichia coli 55989 electron transfer flavoprotein FixA YP_002401180.1 44328 D 585055 CDS YP_002401181.1 218693514 7146115 45113..46054 1 NC_011748.1 involved in electron transfer during carnitine metabolism; electron transfer flavoprotein FixB 46054 fixB 7146115 fixB Escherichia coli 55989 electron transfer flavoprotein FixB YP_002401181.1 45113 D 585055 CDS YP_002401182.1 218693515 7146116 46105..47391 1 NC_011748.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; oxidoreductase FixC 47391 fixC 7146116 fixC Escherichia coli 55989 oxidoreductase FixC YP_002401182.1 46105 D 585055 CDS YP_002401183.1 218693516 7146117 47388..47675 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96066354, 12081978; Product type pc : carrier; 4Fe-4S ferredoxin 47675 fixX 7146117 fixX Escherichia coli 55989 4Fe-4S ferredoxin YP_002401183.1 47388 D 585055 CDS YP_002401184.1 218693517 7146118 47734..49065 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 49065 yaaU 7146118 yaaU Escherichia coli 55989 transporter YP_002401184.1 47734 D 585055 CDS YP_002401185.1 218693518 7148006 49173..49703 1 NC_011748.1 Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 49703 kefF 7148006 kefF Escherichia coli 55989 glutathione-regulated potassium-efflux system ancillary protein KefF YP_002401185.1 49173 D 585055 CDS YP_002401186.1 218693519 7146669 49696..51558 1 NC_011748.1 transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 51558 kefC 7146669 kefC Escherichia coli 55989 glutathione-regulated potassium-efflux system protein KefC YP_002401186.1 49696 D 585055 CDS YP_002401187.1 218693520 7146668 51750..52229 1 NC_011748.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 52229 folA 7146668 folA Escherichia coli 55989 dihydrofolate reductase YP_002401187.1 51750 D 585055 CDS YP_002401188.1 218693521 7146168 complement(52307..53149) 1 NC_011748.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase 53149 apaH 7146168 apaH Escherichia coli 55989 diadenosine tetraphosphatase YP_002401188.1 52307 R 585055 CDS YP_002401189.1 218693522 7145506 complement(53156..53533) 1 NC_011748.1 protein associated with Co2+ and Mg2+ efflux; ApaG protein 53533 apaG 7145506 apaG Escherichia coli 55989 ApaG protein YP_002401189.1 53156 R 585055 CDS YP_002401190.1 218693523 7145505 complement(53536..54357) 1 NC_011748.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase 54357 ksgA 7145505 ksgA Escherichia coli 55989 dimethyladenosine transferase YP_002401190.1 53536 R 585055 CDS YP_002401191.1 218693524 7146673 complement(54354..55343) 1 NC_011748.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase 55343 pdxA 7146673 pdxA Escherichia coli 55989 4-hydroxythreonine-4-phosphate dehydrogenase YP_002401191.1 54354 R 585055 CDS YP_002401192.1 218693525 7147124 complement(55343..56629) 1 NC_011748.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA 56629 surA 7147124 surA Escherichia coli 55989 peptidyl-prolyl cis-trans isomerase SurA YP_002401192.1 55343 R 585055 CDS YP_002401193.1 218693526 7147740 complement(56682..59036) 1 NC_011748.1 determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein 59036 imp 7147740 imp Escherichia coli 55989 organic solvent tolerance protein YP_002401193.1 56682 R 585055 CDS YP_002401194.1 218693527 7146563 59291..60106 1 NC_011748.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 60106 djlA 7146563 djlA Escherichia coli 55989 Dna-J like membrane chaperone protein YP_002401194.1 59291 D 585055 CDS YP_002401195.1 218693528 7145921 complement(60223..60882) 1 NC_011748.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A 60882 rluA 7145921 rluA Escherichia coli 55989 23S rRNA/tRNA pseudouridine synthase A YP_002401195.1 60223 R 585055 CDS YP_002401196.1 218693529 7147426 complement(60894..63800) 1 NC_011748.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA 63800 hepA 7147426 hepA Escherichia coli 55989 ATP-dependent helicase HepA YP_002401196.1 60894 R 585055 CDS YP_002401197.1 218693530 7146419 complement(63965..66316) 1 NC_011748.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II 66316 polB 7146419 polB Escherichia coli 55989 DNA polymerase II YP_002401197.1 63965 R 585055 CDS YP_002401198.1 218693531 7147208 complement(66391..67086) 1 NC_011748.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 67086 araD 7147208 araD Escherichia coli 55989 L-ribulose-5-phosphate 4-epimerase YP_002401198.1 66391 R 585055 CDS YP_002401199.1 218693532 7145516 complement(67255..68757) 1 NC_011748.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase 68757 araA 7145516 araA Escherichia coli 55989 L-arabinose isomerase YP_002401199.1 67255 R 585055 CDS YP_002401200.1 218693533 7145513 complement(68768..70468) 1 NC_011748.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase 70468 araB 7145513 araB Escherichia coli 55989 ribulokinase YP_002401200.1 68768 R 585055 CDS YP_002401201.1 218693534 7145514 70807..71685 1 NC_011748.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 71685 araC 7145514 araC Escherichia coli 55989 DNA-binding transcriptional regulator AraC YP_002401201.1 70807 D 585055 CDS YP_002401202.1 218693535 7145515 71771..72535 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 72535 yabI 7145515 yabI Escherichia coli 55989 inner membrane protein YP_002401202.1 71771 D 585055 CDS YP_002401203.1 218693536 7148009 complement(72649..73347) 1 NC_011748.1 with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit 73347 thiQ 7148009 thiQ Escherichia coli 55989 thiamine transporter ATP-binding subunit YP_002401203.1 72649 R 585055 CDS YP_002401204.1 218693537 7147792 complement(73331..74941) 1 NC_011748.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein 74941 thiP 7147792 thiP Escherichia coli 55989 thiamine transporter membrane protein YP_002401204.1 73331 R 585055 CDS YP_002401205.1 218693538 7147791 complement(74917..75900) 1 NC_011748.1 part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit 75900 tbpA 7147791 tbpA Escherichia coli 55989 thiamine transporter substrate binding subunit YP_002401205.1 74917 R 585055 CDS YP_002401206.1 218693539 7145304 complement(76064..77719) 1 NC_011748.1 activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR 77719 sgrR 7145304 sgrR Escherichia coli 55989 transcriptional regulator SgrR YP_002401206.1 76064 R 585055 CDS YP_002401207.1 218693540 7147651 78041..79219 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438463, 10209755; Product type t : transporter; broad specificity sugar efflux system 79219 setA 7147651 setA Escherichia coli 55989 broad specificity sugar efflux system YP_002401207.1 78041 D 585055 CDS YP_002401208.1 218693541 7147636 complement(79268..79873) 1 NC_011748.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit 79873 leuD 7147636 leuD Escherichia coli 55989 isopropylmalate isomerase small subunit YP_002401208.1 79268 R 585055 CDS YP_002401209.1 218693542 7146692 complement(79884..81284) 1 NC_011748.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit 81284 leuC 7146692 leuC Escherichia coli 55989 isopropylmalate isomerase large subunit YP_002401209.1 79884 R 585055 CDS YP_002401210.1 218693543 7146691 complement(81287..82378) 1 NC_011748.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase 82378 leuB 7146691 leuB Escherichia coli 55989 3-isopropylmalate dehydrogenase YP_002401210.1 81287 R 585055 CDS YP_002401211.1 218693544 7146690 complement(82378..83949) 1 NC_011748.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase 83949 leuA 7146690 leuA Escherichia coli 55989 2-isopropylmalate synthase YP_002401211.1 82378 R 585055 CDS YP_002401212.1 218693545 7145306 complement(84042..84128) 1 NC_011748.1 involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide 84128 leuL 7145306 leuL Escherichia coli 55989 leu operon leader peptide YP_002401212.1 84042 R 585055 CDS YP_002401213.1 218693546 7146693 84788..85732 1 NC_011748.1 activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 85732 leuO 7146693 leuO Escherichia coli 55989 leucine transcriptional activator YP_002401213.1 84788 D 585055 CDS YP_002401214.1 218693547 7146694 86050..87774 1 NC_011748.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 87774 ilvI 7146694 ilvI Escherichia coli 55989 acetolactate synthase 3 catalytic subunit YP_002401214.1 86050 D 585055 CDS YP_002401215.1 218693548 7146556 87777..88268 1 NC_011748.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 88268 ilvH 7146556 ilvH Escherichia coli 55989 acetolactate synthase 3 regulatory subunit YP_002401215.1 87777 D 585055 CDS YP_002401216.1 218693549 7146555 88448..89452 1 NC_011748.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 89452 fruR 7146555 fruR Escherichia coli 55989 DNA-binding transcriptional regulator FruR YP_002401216.1 88448 D 585055 CDS YP_002401217.1 218693550 7146198 90054..90512 1 NC_011748.1 MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 90512 mraZ 7146198 mraZ Escherichia coli 55989 cell division protein MraZ YP_002401217.1 90054 D 585055 CDS YP_002401218.1 218693551 7146897 90514..91455 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042184, 10493123, 2187182, 6350821; Product type e : enzyme; S-adenosyl-methyltransferase MraW 91455 mraW 7146897 mraW Escherichia coli 55989 S-adenosyl-methyltransferase MraW YP_002401218.1 90514 D 585055 CDS YP_002401219.1 218693552 7146895 91452..91817 1 NC_011748.1 membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 91817 ftsL 7146895 ftsL Escherichia coli 55989 cell division protein FtsL YP_002401219.1 91452 D 585055 CDS YP_002401220.1 218693553 7146216 91833..93599 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91072213, 92202178, 94095121, 9603865, 9614966, 1332942, 1447153, 2198024, 2677607, 2681146, 3049550, 3911028, 6350821; Product type e : enzyme; transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) 93599 ftsI 7146216 ftsI Escherichia coli 55989 transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) YP_002401220.1 91833 D 585055 CDS YP_002401221.1 218693554 7146214 93586..95073 1 NC_011748.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 95073 murE 7146214 murE Escherichia coli 55989 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase YP_002401221.1 93586 D 585055 CDS YP_002401222.1 218693555 7146925 95070..96428 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88273095, 90248455, 91310568, 97128642, 11090285, 2668880, 9166795; Product type e : enzyme; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 96428 murF 7146925 murF Escherichia coli 55989 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase YP_002401222.1 95070 D 585055 CDS YP_002401223.1 218693556 7146926 96422..97504 1 NC_011748.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 97504 mraY 7146926 mraY Escherichia coli 55989 phospho-N-acetylmuramoyl-pentapeptide- transferase YP_002401223.1 96422 D 585055 CDS YP_002401224.1 218693557 7146896 97507..98823 1 NC_011748.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 98823 murD 7146896 murD Escherichia coli 55989 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase YP_002401224.1 97507 D 585055 CDS YP_002401225.1 218693558 7146924 98823..100067 1 NC_011748.1 integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 100067 ftsW 7146924 ftsW Escherichia coli 55989 cell division protein FtsW YP_002401225.1 98823 D 585055 CDS YP_002401226.1 218693559 7146219 100064..101131 1 NC_011748.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 101131 murG 7146219 murG Escherichia coli 55989 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase YP_002401226.1 100064 D 585055 CDS YP_002401227.1 218693560 7146927 101185..102660 1 NC_011748.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 102660 murC 7146927 murC Escherichia coli 55989 UDP-N-acetylmuramate--L-alanine ligase YP_002401227.1 101185 D 585055 CDS YP_002401228.1 218693561 7146923 102653..103573 1 NC_011748.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 103573 ddl 7146923 ddl Escherichia coli 55989 D-alanine--D-alanine ligase YP_002401228.1 102653 D 585055 CDS YP_002401229.1 218693562 7145868 103575..104405 1 NC_011748.1 involved in septum formation; cell division protein FtsQ 104405 ftsQ 7145868 ftsQ Escherichia coli 55989 cell division protein FtsQ YP_002401229.1 103575 D 585055 CDS YP_002401230.1 218693563 7146218 104402..105664 1 NC_011748.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 105664 ftsA 7146218 ftsA Escherichia coli 55989 cell division protein FtsA YP_002401230.1 104402 D 585055 CDS YP_002401231.1 218693564 7146210 105725..106876 1 NC_011748.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 106876 ftsZ 7146210 ftsZ Escherichia coli 55989 cell division protein FtsZ YP_002401231.1 105725 D 585055 CDS YP_002401232.1 218693565 7146222 106977..107894 1 NC_011748.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 107894 lpxC 7146222 lpxC Escherichia coli 55989 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase YP_002401232.1 106977 D 585055 CDS YP_002401233.1 218693566 7146737 108125..108637 1 NC_011748.1 secM translational pause allows for the initiation of secA translation; SecA regulator SecM 108637 secM 7146737 secM Escherichia coli 55989 SecA regulator SecM YP_002401233.1 108125 D 585055 CDS YP_002401234.1 218693567 7147626 108699..111404 1 NC_011748.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 111404 secA 7147626 secA Escherichia coli 55989 preprotein translocase subunit SecA YP_002401234.1 108699 D 585055 CDS YP_002401235.1 218693568 7147620 111464..111853 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10218109, 89264540, 90136514, 91225007, 97444511, 1309939, 2841285, 3033442, 3288626, 7578113, 9063868; Product type e : enzyme; nucleoside triphosphate pyrophosphohydrolase 111853 mutT 7147620 mutT Escherichia coli 55989 nucleoside triphosphate pyrophosphohydrolase YP_002401235.1 111464 D 585055 CDS YP_002401236.1 218693569 7146935 complement(112160..112903) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 112903 yacF 7146935 yacF Escherichia coli 55989 hypothetical protein YP_002401236.1 112160 R 585055 CDS YP_002401237.1 218693570 7148011 complement(112903..113523) 1 NC_011748.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase 113523 coaE 7148011 coaE Escherichia coli 55989 dephospho-CoA kinase YP_002401237.1 112903 R 585055 CDS YP_002401238.1 218693571 7145734 113748..114791 1 NC_011748.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 114791 guaC 7145734 guaC Escherichia coli 55989 guanosine 5'-monophosphate oxidoreductase YP_002401238.1 113748 D 585055 CDS YP_002401239.1 218693572 7146380 complement(114826..116028) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96099298, 2904262, 7959070; Product type s : structure; type IV pilin biogenesis protein 116028 hofC 7146380 hofC Escherichia coli 55989 type IV pilin biogenesis protein YP_002401239.1 114826 R 585055 CDS YP_002401240.1 218693573 7146450 complement(116018..117403) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96099298, 7959070; Product type pt : transporter; hypothetical protein 117403 hofB 7146450 hofB Escherichia coli 55989 hypothetical protein YP_002401240.1 116018 R 585055 CDS YP_002401241.1 218693574 7146449 complement(117413..117853) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20100782, 20271862, 96099298, 7959070; Product type ps : structure; major pilin subunit 117853 ppdD 7146449 ppdD Escherichia coli 55989 major pilin subunit YP_002401241.1 117413 R 585055 CDS YP_002401242.1 218693575 7147225 complement(118056..118949) 1 NC_011748.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase 118949 nadC 7147225 nadC Escherichia coli 55989 quinolinate phosphoribosyltransferase YP_002401242.1 118056 R 585055 CDS YP_002401243.1 218693576 7146944 119037..119588 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90113890, 95047240, 2607970, 7959070; Product type e : enzyme; N-acetyl-anhydromuranmyl-L-alanine amidase 119588 ampD 7146944 ampD Escherichia coli 55989 N-acetyl-anhydromuranmyl-L-alanine amidase YP_002401243.1 119037 D 585055 CDS YP_002401244.1 218693577 7145495 119585..120439 1 NC_011748.1 involved in regulation of beta-lactamase; signaling protein; regulatory protein AmpE 120439 ampE 7145495 ampE Escherichia coli 55989 regulatory protein AmpE YP_002401244.1 119585 D 585055 CDS YP_002401245.1 218693578 7145496 complement(120482..121855) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1104763, 90174991, 9150230; Product type t : transporter; aromatic amino acid transporter 121855 aroP 7145496 aroP Escherichia coli 55989 aromatic amino acid transporter YP_002401245.1 120482 R 585055 CDS YP_002401246.1 218693579 7145550 122396..123160 1 NC_011748.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 123160 pdhR 7145550 pdhR Escherichia coli 55989 transcriptional regulator PdhR YP_002401246.1 122396 D 585055 CDS YP_002401247.1 218693580 7147829 123321..125984 1 NC_011748.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 125984 aceE 7147829 aceE Escherichia coli 55989 pyruvate dehydrogenase subunit E1 YP_002401247.1 123321 D 585055 CDS YP_002401248.1 218693581 7145434 125999..127891 1 NC_011748.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 127891 aceF 7145434 aceF Escherichia coli 55989 dihydrolipoamide acetyltransferase YP_002401248.1 125999 D 585055 CDS YP_002401249.1 218693582 7145435 128216..129640 1 NC_011748.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 129640 lpd 7145435 lpd Escherichia coli 55989 dihydrolipoamide dehydrogenase YP_002401249.1 128216 D 585055 CDS YP_002401250.1 218693583 7146722 complement(129711..131468) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 131468 yacH 7146722 yacH Escherichia coli 55989 hypothetical protein YP_002401250.1 129711 R 585055 CDS YP_002401251.1 218693584 7148012 131823..134420 1 NC_011748.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 134420 acnB 7148012 acnB Escherichia coli 55989 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase YP_002401251.1 131823 D 585055 CDS YP_002401252.1 218693585 7145439 134596..134958 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401, 7567469; hypothetical protein 134958 yacL 7145439 yacL Escherichia coli 55989 hypothetical protein YP_002401252.1 134596 D 585055 CDS YP_002401253.1 218693586 7148013 complement(134996..135790) 1 NC_011748.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase 135790 speD 7148013 speD Escherichia coli 55989 S-adenosylmethionine decarboxylase YP_002401253.1 134996 R 585055 CDS YP_002401254.1 218693587 7147688 complement(135806..136672) 1 NC_011748.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase 136672 speE 7147688 speE Escherichia coli 55989 spermidine synthase YP_002401254.1 135806 R 585055 CDS YP_002401255.1 218693588 7147689 complement(136778..137296) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401; hypothetical protein 137296 yacC 7147689 yacC Escherichia coli 55989 hypothetical protein YP_002401255.1 136778 R 585055 CDS YP_002401256.1 218693589 7148010 137291..138841 1 NC_011748.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 138841 cueO 7148010 cueO Escherichia coli 55989 multicopper oxidase YP_002401256.1 137291 D 585055 CDS YP_002401257.1 218693590 7145788 complement(138888..141278) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10359647, 11604400, 14612441, 91035240, 93123180, 93286127; Product type e : enzyme; glucose dehydrogenase 141278 gcd 7145788 gcd Escherichia coli 55989 glucose dehydrogenase YP_002401257.1 138888 R 585055 CDS YP_002401258.1 218693591 7146271 141484..142020 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 13808016, 339828, 6787390, 6801015, 12070315; Product type e : enzyme; hypoxanthine phosphoribosyltransferase 142020 hpt 7146271 hpt Escherichia coli 55989 hypoxanthine phosphoribosyltransferase YP_002401258.1 141484 D 585055 CDS YP_002401259.1 218693592 7146458 complement(142061..142723) 1 NC_011748.1 catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase 142723 can 7146458 can Escherichia coli 55989 carbonic anhydrase YP_002401259.1 142061 R 585055 CDS YP_002401260.1 218693593 7145663 142832..143758 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: ATP-binding component of ABC superfamily 143758 yadG 7145663 yadG Escherichia coli 55989 transporter subunit: ATP-binding component of ABC superfamily YP_002401260.1 142832 D 585055 CDS YP_002401261.1 218693594 7148017 143755..144525 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10474187; Product type pt : transporter; transporter subunit: membrane component of ABC superfamily 144525 yadH 7148017 yadH Escherichia coli 55989 transporter subunit: membrane component of ABC superfamily YP_002401261.1 143755 D 585055 CDS YP_002401262.1 218693595 7148018 144630..145070 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; PTS Enzyme IIA 145070 yadI 7148018 yadI Escherichia coli 55989 PTS Enzyme IIA YP_002401262.1 144630 D 585055 CDS YP_002401263.1 218693596 7148019 145134..146363 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; polysaccharide deacetylase 146363 yadE 7148019 yadE Escherichia coli 55989 polysaccharide deacetylase YP_002401263.1 145134 D 585055 CDS YP_002401264.1 218693597 7148016 complement(146367..146747) 1 NC_011748.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase 146747 panD 7148016 panD Escherichia coli 55989 aspartate alpha-decarboxylase YP_002401264.1 146367 R 585055 CDS YP_002401265.1 218693598 7147112 147021..147923 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11319082; Product type pe : enzyme; transposase 147923 yadD 7147112 yadD Escherichia coli 55989 transposase YP_002401265.1 147021 D 585055 CDS YP_002401266.1 218693599 7148015 complement(147997..148848) 1 NC_011748.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase 148848 panC 7148015 panC Escherichia coli 55989 pantoate--beta-alanine ligase YP_002401266.1 147997 R 585055 CDS YP_002401267.1 218693600 7147111 complement(148860..149654) 1 NC_011748.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase 149654 panB 7147111 panB Escherichia coli 55989 3-methyl-2-oxobutanoate hydroxymethyltransferase YP_002401267.1 148860 R 585055 CDS YP_002401268.1 218693601 7147110 complement(149767..151041) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8096212; Product type ps : structure; fimbrial-like adhesin protein 151041 7147110 EC55989_0129 Escherichia coli 55989 fimbrial-like adhesin protein YP_002401268.1 149767 R 585055 CDS YP_002401269.1 218693602 7144361 complement(151094..151690) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 151690 yadK 7144361 yadK Escherichia coli 55989 fimbrial-like adhesin protein YP_002401269.1 151094 R 585055 CDS YP_002401270.1 218693603 7148020 complement(151717..152319) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 152319 yadL 7148020 yadL Escherichia coli 55989 fimbrial-like adhesin protein YP_002401270.1 151717 R 585055 CDS YP_002401271.1 218693604 7148021 complement(152334..152903) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 152903 yadM 7148021 yadM Escherichia coli 55989 fimbrial-like adhesin protein YP_002401271.1 152334 R 585055 CDS YP_002401272.1 218693605 7148022 complement(152920..155520) 1 NC_011748.1 similar to the fimbrial usher protein PapC; outer membrane usher protein 155520 htrE 7148022 htrE Escherichia coli 55989 outer membrane usher protein YP_002401272.1 152920 R 585055 CDS YP_002401273.1 218693606 7146477 complement(155555..156295) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 93352405, 8102362, 15561151; Product type f : factor; chaperone protein EcpD 156295 ecpD 7146477 ecpD Escherichia coli 55989 chaperone protein EcpD YP_002401273.1 155555 R 585055 CDS YP_002401274.1 218693607 7145975 complement(156400..156984) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 156984 yadN 7145975 yadN Escherichia coli 55989 fimbrial-like adhesin protein YP_002401274.1 156400 R 585055 CDS YP_002401275.1 218693608 7148023 complement(157354..157833) 1 NC_011748.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase 157833 folK 7148023 folK Escherichia coli 55989 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase YP_002401275.1 157354 R 585055 CDS YP_002401276.1 218693609 7146173 complement(157830..159248) 1 NC_011748.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase 159248 pcnB 7146173 pcnB Escherichia coli 55989 poly(A) polymerase YP_002401276.1 157830 R 585055 CDS YP_002401277.1 218693610 7147122 complement(159287..160213) 1 NC_011748.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase 160213 yadB 7147122 yadB Escherichia coli 55989 glutamyl-Q tRNA(Asp) synthetase YP_002401277.1 159287 R 585055 CDS YP_002401278.1 218693611 7148014 complement(160250..160705) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294157, 90202727, 2013578, 9298646, 9600841; Product type r : regulator; RNA polymerase-binding transcription factor 160705 dksA 7148014 dksA Escherichia coli 55989 RNA polymerase-binding transcription factor YP_002401278.1 160250 R 585055 CDS YP_002401279.1 218693612 7145926 complement(160883..161587) 1 NC_011748.1 Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A 161587 sfsA 7145926 sfsA Escherichia coli 55989 sugar fermentation stimulation protein A YP_002401279.1 160883 R 585055 CDS YP_002401280.1 218693613 7147645 complement(161602..162132) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97094878; Product type e : enzyme; 2'-5' RNA ligase 162132 ligT 7147645 ligT Escherichia coli 55989 2'-5' RNA ligase YP_002401280.1 161602 R 585055 CDS YP_002401281.1 218693614 7146702 162206..164635 1 NC_011748.1 similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 164635 hrpB 7146702 hrpB Escherichia coli 55989 ATP-dependent RNA helicase HrpB YP_002401281.1 162206 D 585055 CDS YP_002401282.1 218693615 7146460 164831..167365 1 NC_011748.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 167365 mrcB 7146460 mrcB Escherichia coli 55989 penicillin-binding protein 1b YP_002401282.1 164831 D 585055 CDS YP_002401283.1 218693616 7146899 167585..169828 1 NC_011748.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 169828 fhuA 7146899 fhuA Escherichia coli 55989 ferrichrome outer membrane transporter YP_002401283.1 167585 D 585055 CDS YP_002401284.1 218693617 7146099 169879..170676 1 NC_011748.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 170676 fhuC 7146099 fhuC Escherichia coli 55989 iron-hydroxamate transporter ATP-binding subunit YP_002401284.1 169879 D 585055 CDS YP_002401285.1 218693618 7146101 170676..171566 1 NC_011748.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 171566 fhuD 7146101 fhuD Escherichia coli 55989 iron-hydroxamate transporter substrate-binding subunit YP_002401285.1 170676 D 585055 CDS YP_002401286.1 218693619 7146102 171563..173545 1 NC_011748.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 173545 fhuB 7146102 fhuB Escherichia coli 55989 iron-hydroxamate transporter permease subunit YP_002401286.1 171563 D 585055 CDS YP_002401287.1 218693620 7146100 complement(173580..174860) 1 NC_011748.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase 174860 hemL 7146100 hemL Escherichia coli 55989 glutamate-1-semialdehyde aminotransferase YP_002401287.1 173580 R 585055 CDS YP_002401288.1 218693621 7146415 175085..176506 1 NC_011748.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 176506 clcA 7146415 clcA Escherichia coli 55989 chloride channel protein YP_002401288.1 175085 D 585055 CDS YP_002401289.1 218693622 7145718 176588..176932 1 NC_011748.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 176932 yadR 7145718 yadR Escherichia coli 55989 iron-sulfur cluster insertion protein ErpA YP_002401289.1 176588 D 585055 CDS YP_002401290.1 218693623 7148024 complement(176979..177602) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 177602 yadS 7148024 yadS Escherichia coli 55989 hypothetical protein YP_002401290.1 176979 R 585055 CDS YP_002401291.1 218693624 7148025 complement(177640..178440) 1 NC_011748.1 solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF 178440 btuF 7148025 btuF Escherichia coli 55989 vitamin B12-transporter protein BtuF YP_002401291.1 177640 R 585055 CDS YP_002401292.1 218693625 7145643 complement(178433..179131) 1 NC_011748.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase 179131 pfs 7145643 pfs Escherichia coli 55989 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase YP_002401292.1 178433 R 585055 CDS YP_002401293.1 218693626 7147145 179215..180732 1 NC_011748.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 180732 dgt 7147145 dgt Escherichia coli 55989 deoxyguanosinetriphosphate triphosphohydrolase YP_002401293.1 179215 D 585055 CDS YP_002401294.1 218693627 7145901 180862..182286 1 NC_011748.1 protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 182286 degP 7145901 degP Escherichia coli 55989 serine endoprotease YP_002401294.1 180862 D 585055 CDS YP_002401295.1 218693628 7145879 182441..183598 1 NC_011748.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 183598 cdaR 7145879 cdaR Escherichia coli 55989 carbohydrate diacid transcriptional activator CdaR YP_002401295.1 182441 D 585055 CDS YP_002401296.1 218693629 7145682 complement(183687..184073) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 184073 yaeH 7145682 yaeH Escherichia coli 55989 hypothetical protein YP_002401296.1 183687 R 585055 CDS YP_002401297.1 218693630 7148029 complement(184388..185212) 1 NC_011748.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase 185212 dapD 7148029 dapD Escherichia coli 55989 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase YP_002401297.1 184388 R 585055 CDS YP_002401298.1 218693631 7145851 complement(185243..187915) 1 NC_011748.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase 187915 glnD 7145851 glnD Escherichia coli 55989 PII uridylyl-transferase YP_002401298.1 185243 R 585055 CDS YP_002401299.1 218693632 7146304 complement(187977..188771) 1 NC_011748.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase 188771 map 7146304 map Escherichia coli 55989 methionine aminopeptidase YP_002401299.1 187977 R 585055 CDS YP_002401300.1 218693633 7146786 complement(188771..188992) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 188992 7146786 EC55989_0162 Escherichia coli 55989 hypothetical protein YP_002401300.1 188771 R 585055 CDS YP_002401301.1 218693634 7147744 189139..189864 1 NC_011748.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 189864 rpsB 7147744 rpsB Escherichia coli 55989 30S ribosomal protein S2 YP_002401301.1 189139 D 585055 CDS YP_002401302.1 218693635 7147506 190122..190973 1 NC_011748.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 190973 tsf 7147506 tsf Escherichia coli 55989 elongation factor Ts YP_002401302.1 190122 D 585055 CDS YP_002401303.1 218693636 7147865 191120..191845 1 NC_011748.1 Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 191845 pyrH 7147865 pyrH Escherichia coli 55989 uridylate kinase YP_002401303.1 191120 D 585055 CDS YP_002401304.1 218693637 7147323 192137..192694 1 NC_011748.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 192694 frr 7147323 frr Escherichia coli 55989 ribosome recycling factor YP_002401304.1 192137 D 585055 CDS YP_002401305.1 218693638 7146193 192786..193982 1 NC_011748.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 193982 dxr 7146193 dxr Escherichia coli 55989 1-deoxy-D-xylulose 5-phosphate reductoisomerase YP_002401305.1 192786 D 585055 CDS YP_002401306.1 218693639 7145963 194168..194929 1 NC_011748.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 194929 ispU 7145963 ispU Escherichia coli 55989 undecaprenyl pyrophosphate synthase YP_002401306.1 194168 D 585055 CDS YP_002401307.1 218693640 7146632 194942..195799 1 NC_011748.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 195799 cdsA 7146632 cdsA Escherichia coli 55989 CDP-diglyceride synthase YP_002401307.1 194942 D 585055 CDS YP_002401308.1 218693641 7145685 195811..197163 1 NC_011748.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 197163 yaeL 7145685 yaeL Escherichia coli 55989 zinc metallopeptidase RseP YP_002401308.1 195811 D 585055 CDS YP_002401309.1 218693642 7148031 197193..199625 1 NC_011748.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 199625 yaeT 7148031 yaeT Escherichia coli 55989 outer membrane protein assembly factor YaeT YP_002401309.1 197193 D 585055 CDS YP_002401310.1 218693643 7148035 199747..200232 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15101556, 90201355, 97032152, 99386928, 1987124, 2843433, 9298646, 2167239; Product type f : factor; periplasmic chaperone 200232 hlpA 7148035 hlpA Escherichia coli 55989 periplasmic chaperone YP_002401310.1 199747 D 585055 CDS YP_002401311.1 218693644 7146444 200236..201261 1 NC_011748.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 201261 lpxD 7146444 lpxD Escherichia coli 55989 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase YP_002401311.1 200236 D 585055 CDS YP_002401312.1 218693645 7146738 201366..201821 1 NC_011748.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 201821 fabZ 7146738 fabZ Escherichia coli 55989 (3R)-hydroxymyristoyl-ACP dehydratase YP_002401312.1 201366 D 585055 CDS YP_002401313.1 218693646 7146054 201825..202613 1 NC_011748.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 202613 lpxA 7146054 lpxA Escherichia coli 55989 UDP-N-acetylglucosamine acyltransferase YP_002401313.1 201825 D 585055 CDS YP_002401314.1 218693647 7146735 202613..203761 1 NC_011748.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 203761 lpxB 7146735 lpxB Escherichia coli 55989 lipid-A-disaccharide synthase YP_002401314.1 202613 D 585055 CDS YP_002401315.1 218693648 7146736 203758..204354 1 NC_011748.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 204354 rnhB 7146736 rnhB Escherichia coli 55989 ribonuclease HII YP_002401315.1 203758 D 585055 CDS YP_002401316.1 218693649 7147451 204391..207873 1 NC_011748.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 207873 dnaE 7147451 dnaE Escherichia coli 55989 DNA polymerase III subunit alpha YP_002401316.1 204391 D 585055 CDS YP_002401317.1 218693650 7145935 207886..208845 1 NC_011748.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 208845 accA 7145935 accA Escherichia coli 55989 acetyl-CoA carboxylase carboxyltransferase subunit alpha YP_002401317.1 207886 D 585055 CDS YP_002401318.1 218693651 7145428 208944..211085 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97480927, 98195734, 98357244, 9226257, 9723924; Product type e : enzyme; lysine decarboxylase 2, constitutive 211085 ldcC 7145428 ldcC Escherichia coli 55989 lysine decarboxylase 2, constitutive YP_002401318.1 208944 D 585055 CDS YP_002401319.1 218693652 7146681 211142..211531 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 211531 yaeR 7146681 yaeR Escherichia coli 55989 hypothetical protein YP_002401319.1 211142 D 585055 CDS YP_002401320.1 218693653 7148034 211596..212894 1 NC_011748.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 212894 tilS 7148034 tilS Escherichia coli 55989 tRNA(Ile)-lysidine synthetase YP_002401320.1 211596 D 585055 CDS YP_002401321.1 218693654 7147802 complement(212943..213197) 1 NC_011748.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator 213197 rof 7147802 rof Escherichia coli 55989 Rho-binding antiterminator YP_002401321.1 212943 R 585055 CDS YP_002401322.1 218693655 7147458 complement(213190..213390) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 213390 yaeP 7147458 yaeP Escherichia coli 55989 hypothetical protein YP_002401322.1 213190 R 585055 CDS YP_002401323.1 218693656 7148032 213556..214101 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 214101 yaeQ 7148032 yaeQ Escherichia coli 55989 hypothetical protein YP_002401323.1 213556 D 585055 CDS YP_002401324.1 218693657 7148033 214098..214520 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; peptidyl-tRNA hydrolase domain-containing protein 214520 yaeJ 7148033 yaeJ Escherichia coli 55989 peptidyl-tRNA hydrolase domain-containing protein YP_002401324.1 214098 D 585055 CDS YP_002401325.1 218693658 7148030 214534..215244 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11830644, 95362641, 95362642; Product type lp : lipoprotein; lipoprotein involved with copper homeostasis and adhesion 215244 nlpE 7148030 nlpE Escherichia coli 55989 lipoprotein involved with copper homeostasis and adhesion YP_002401325.1 214534 D 585055 CDS YP_002401326.1 218693659 7147010 215494..216474 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 216474 7147010 EC55989_0189 Escherichia coli 55989 transposase, IS110 family YP_002401326.1 215494 D 585055 CDS YP_002401327.1 218693660 7148028 complement(217554..219272) 1 NC_011748.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase 219272 proS 7148028 proS Escherichia coli 55989 prolyl-tRNA synthetase YP_002401327.1 217554 R 585055 CDS YP_002401328.1 218693661 7147257 complement(219384..220091) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 220091 yaeB 7147257 yaeB Escherichia coli 55989 hypothetical protein YP_002401328.1 219384 R 585055 CDS YP_002401329.1 218693662 7148026 complement(220088..220492) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93094132; Product type pr : regulator; outer membrane lipoprotein 220492 rcsF 7148026 rcsF Escherichia coli 55989 outer membrane lipoprotein YP_002401329.1 220088 R 585055 CDS YP_002401330.1 218693663 7147351 complement(220610..221425) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12169620, 12218041, 12819857, 1459951; Product type t : transporter; DL-methionine transporter substrate-binding subunit 221425 metQ 7147351 metQ Escherichia coli 55989 DL-methionine transporter substrate-binding subunit YP_002401330.1 220610 R 585055 CDS YP_002401331.1 218693664 7146836 complement(221465..222118) 1 NC_011748.1 part of the MetNIQ methionine uptake system; DL-methionine transporter permease 222118 metI 7146836 metI Escherichia coli 55989 DL-methionine transporter permease YP_002401331.1 221465 R 585055 CDS YP_002401332.1 218693665 7146831 complement(222111..223142) 1 NC_011748.1 part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit 223142 metN 7146831 metN Escherichia coli 55989 DL-methionine transporter ATP-binding subunit YP_002401332.1 222111 R 585055 CDS YP_002401333.1 218693666 7146835 223330..223902 1 NC_011748.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 223902 gmhB 7146835 gmhB Escherichia coli 55989 D,D-heptose 1,7-bisphosphate phosphatase YP_002401333.1 223330 D 585055 CDS YP_002401334.1 218693667 7145290 229475..229750 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 229750 7145290 EC55989_0204 Escherichia coli 55989 hypothetical protein YP_002401334.1 229475 D 585055 CDS YP_002401335.1 218693668 7145339 229800..230603 1 NC_011748.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 230603 dkgB 7145339 dkgB Escherichia coli 55989 2,5-diketo-D-gluconate reductase B YP_002401335.1 229800 D 585055 CDS YP_002401336.1 218693669 7147443 230714..231922 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L 231922 7147443 EC55989_0206 Escherichia coli 55989 transposase, IS4 family, IS10L YP_002401336.1 230714 D 585055 CDS YP_002401337.1 218693670 7144365 complement(231938..232852) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 232852 yafC 7144365 yafC Escherichia coli 55989 DNA-binding transcriptional regulator YP_002401337.1 231938 R 585055 CDS YP_002401338.1 218693671 7148036 233093..233893 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1663890; hypothetical protein 233893 yafD 7148036 yafD Escherichia coli 55989 hypothetical protein YP_002401338.1 233093 D 585055 CDS YP_002401339.1 218693672 7148037 233971..234741 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; S-adenosyl-L-methionine-dependent methyltransferase 234741 yafE 7148037 yafE Escherichia coli 55989 S-adenosyl-L-methionine-dependent methyltransferase YP_002401339.1 233971 D 585055 CDS YP_002401340.1 218693673 7148038 complement(234789..236147) 1 NC_011748.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D 236147 mltD 7148038 mltD Escherichia coli 55989 membrane-bound lytic murein transglycosylase D YP_002401340.1 234789 R 585055 CDS YP_002401341.1 218693674 7146866 complement(236219..236974) 1 NC_011748.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase 236974 gloB 7146866 gloB Escherichia coli 55989 hydroxyacylglutathione hydrolase YP_002401341.1 236219 R 585055 CDS YP_002401342.1 218693675 7146314 237008..237730 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; S-adenosyl-L-methionine-dependent methyltransferase 237730 yafS 7146314 yafS Escherichia coli 55989 S-adenosyl-L-methionine-dependent methyltransferase YP_002401342.1 237008 D 585055 CDS YP_002401343.1 218693676 7148044 complement(237727..238194) 1 NC_011748.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H 238194 rnhA 7148044 rnhA Escherichia coli 55989 ribonuclease H YP_002401343.1 237727 R 585055 CDS YP_002401344.1 218693677 7147450 238259..238990 1 NC_011748.1 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 238990 dnaQ 7147450 dnaQ Escherichia coli 55989 DNA polymerase III subunit epsilon YP_002401344.1 238259 D 585055 CDS YP_002401345.1 218693678 7145350 239526..240311 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; aminopeptidase 240311 yafT 7145350 yafT Escherichia coli 55989 aminopeptidase YP_002401345.1 239526 D 585055 CDS YP_002401346.1 218693679 7145647 complement(240937..241866) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15919996; Product type m : membrane component; hypothetical protein 241866 yafU 7145647 yafU Escherichia coli 55989 hypothetical protein YP_002401346.1 240937 R 585055 CDS YP_002401347.1 218693680 7148046 complement(241895..242377) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 242377 7148046 EC55989_0218 Escherichia coli 55989 hypothetical protein YP_002401347.1 241895 R 585055 CDS YP_002401348.1 218693681 7144366 complement(242401..243843) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 243843 7144366 EC55989_0219 Escherichia coli 55989 hypothetical protein YP_002401348.1 242401 R 585055 CDS YP_002401349.1 218693682 7144367 complement(243764..247288) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; IcmF-like protein 247288 7144367 EC55989_0220 Escherichia coli 55989 IcmF-like protein YP_002401349.1 243764 R 585055 CDS YP_002401350.1 218693683 7144368 complement(247307..248788) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 248788 7144368 EC55989_0221 Escherichia coli 55989 hypothetical protein YP_002401350.1 247307 R 585055 CDS YP_002401351.1 218693684 7144369 complement(248727..249470) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 249470 7144369 EC55989_0222 Escherichia coli 55989 hypothetical protein YP_002401351.1 248727 R 585055 CDS YP_002401352.1 218693685 7144370 complement(249467..252340) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; ATP-dependent Clp proteinase Aec27 ATP-binding chain, with chaperone activity 252340 7144370 EC55989_0223 Escherichia coli 55989 ATP-dependent Clp proteinase Aec27 ATP-binding chain, with chaperone activity YP_002401352.1 249467 R 585055 CDS YP_002401353.1 218693686 7144371 complement(252235..252996) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; membrane protein Aec26 252996 7144371 EC55989_0224 Escherichia coli 55989 membrane protein Aec26 YP_002401353.1 252235 R 585055 CDS YP_002401354.1 218693687 7144372 complement(253001..254332) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 254332 7144372 EC55989_0225 Escherichia coli 55989 hypothetical protein YP_002401354.1 253001 R 585055 CDS YP_002401355.1 218693688 7144373 complement(254335..254859) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 254859 7144373 EC55989_0226 Escherichia coli 55989 hypothetical protein YP_002401355.1 254335 R 585055 CDS YP_002401356.1 218693689 7144374 complement(254856..256157) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 256157 7144374 EC55989_0227 Escherichia coli 55989 hypothetical protein YP_002401356.1 254856 R 585055 CDS YP_002401357.1 218693690 7144375 complement(256161..257249) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 257249 7144375 EC55989_0228 Escherichia coli 55989 hypothetical protein YP_002401357.1 256161 R 585055 CDS YP_002401358.1 218693691 7144376 complement(257207..259057) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 259057 7144376 EC55989_0229 Escherichia coli 55989 hypothetical protein YP_002401358.1 257207 R 585055 CDS YP_002401359.1 218693692 7144377 complement(259061..259474) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 259474 7144377 EC55989_0230 Escherichia coli 55989 hypothetical protein YP_002401359.1 259061 R 585055 CDS YP_002401360.1 218693693 7144378 complement(259481..260956) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 260956 7144378 EC55989_0231 Escherichia coli 55989 hypothetical protein YP_002401360.1 259481 R 585055 CDS YP_002401361.1 218693694 7144379 complement(261007..261231) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 261231 7144379 EC55989_0232 Escherichia coli 55989 hypothetical protein YP_002401361.1 261007 R 585055 CDS YP_002401362.1 218693695 7144380 complement(261266..261766) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 261766 7144380 EC55989_0233 Escherichia coli 55989 hypothetical protein YP_002401362.1 261266 R 585055 CDS YP_002401363.1 218693696 7144381 262193..262336 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 262336 7144381 EC55989_0234 Escherichia coli 55989 hypothetical protein YP_002401363.1 262193 D 585055 CDS YP_002401364.1 218693697 7144382 262463..262981 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 262981 7144382 EC55989_0235 Escherichia coli 55989 hypothetical protein YP_002401364.1 262463 D 585055 CDS YP_002401365.1 218693698 7144383 263191..265332 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 265332 7144383 EC55989_0236 Escherichia coli 55989 hypothetical protein YP_002401365.1 263191 D 585055 CDS YP_002401366.1 218693699 7147405 269055..269537 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 269537 ydcD 7147405 ydcD Escherichia coli 55989 hypothetical protein YP_002401366.1 269055 D 585055 CDS YP_002401367.1 218693700 7148384 269718..270464 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7868617, 8387990; hypothetical protein 270464 yncI 7148384 yncI Escherichia coli 55989 hypothetical protein YP_002401367.1 269718 D 585055 CDS YP_002401368.1 218693701 7149297 270508..270708 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7868617, 8387990; hypothetical protein 270708 yncM 7149297 yncM Escherichia coli 55989 hypothetical protein YP_002401368.1 270508 D 585055 CDS YP_002401369.1 218693702 7149299 271022..272083 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype; transposase 272083 yhhI 7149299 yhhI Escherichia coli 55989 transposase YP_002401369.1 271022 D 585055 CDS YP_002401370.1 218693703 7148979 complement(272125..272895) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8526497; Product type pe : enzyme; hypothetical protein 272895 yafV 7148979 yafV Escherichia coli 55989 hypothetical protein YP_002401370.1 272125 R 585055 CDS YP_002401371.1 218693704 7148047 273049..273522 1 NC_011748.1 inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 273522 ivy 7148047 ivy Escherichia coli 55989 C-lysozyme inhibitor YP_002401371.1 273049 D 585055 CDS YP_002401372.1 218693705 7146643 complement(273565..276009) 1 NC_011748.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase 276009 fadE 7146643 fadE Escherichia coli 55989 acyl-CoA dehydrogenase YP_002401372.1 273565 R 585055 CDS YP_002401373.1 218693706 7146058 276249..276827 1 NC_011748.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 276827 gmhA 7146058 gmhA Escherichia coli 55989 phosphoheptose isomerase YP_002401373.1 276249 D 585055 CDS YP_002401374.1 218693707 7146721 277033..277800 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; class-II glutamine amidotransferase 277800 yafJ 7146721 yafJ Escherichia coli 55989 class-II glutamine amidotransferase YP_002401374.1 277033 D 585055 CDS YP_002401375.1 218693708 7148039 complement(277771..278511) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 278511 yafK 7148039 yafK Escherichia coli 55989 hypothetical protein YP_002401375.1 277771 R 585055 CDS YP_002401376.1 218693709 7148040 complement(278667..278945) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15009896; Product type f : factor; toxin of the YafQ-DinJ toxin-antitoxin system 278945 yafQ 7148040 yafQ Escherichia coli 55989 toxin of the YafQ-DinJ toxin-antitoxin system YP_002401376.1 278667 R 585055 CDS YP_002401377.1 218693710 7148043 complement(278948..279208) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99451883; Product type pf : factor; antitoxin of YafQ-DinJ toxin-antitoxin system 279208 dinJ 7148043 dinJ Escherichia coli 55989 antitoxin of YafQ-DinJ toxin-antitoxin system YP_002401377.1 278948 R 585055 CDS YP_002401378.1 218693711 7145919 279418..280167 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase 280167 yafL 7145919 yafL Escherichia coli 55989 hydrolase YP_002401378.1 279418 D 585055 CDS YP_002401379.1 218693712 7148041 complement(280224..280580) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 280580 7148041 EC55989_0252 Escherichia coli 55989 hypothetical protein YP_002401379.1 280224 R 585055 CDS YP_002401380.1 218693713 7144386 complement(280573..280872) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 280872 7144386 EC55989_0253 Escherichia coli 55989 hypothetical protein YP_002401380.1 280573 R 585055 CDS YP_002401381.1 218693714 7144387 complement(280956..282695) 1 NC_011748.1 Evidence 7 : Gene remnant; Product type s : structure; flagellar system protein 282695 fhiA 7144387 fhiA Escherichia coli 55989 flagellar system protein YP_002401381.1 280956 R 585055 CDS YP_002401382.1 218693715 7146097 282535..283425 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15687208; Product type s : structure; hypothetical protein 283425 mbhA 7146097 mbhA Escherichia coli 55989 hypothetical protein YP_002401382.1 282535 D 585055 CDS YP_002401383.1 218693716 7146792 283496..284551 1 NC_011748.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 284551 dinB 7146792 dinB Escherichia coli 55989 DNA polymerase IV YP_002401383.1 283496 D 585055 CDS YP_002401384.1 218693717 7148042 complement(284903..286111) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L 286111 7148042 EC55989_0258 Escherichia coli 55989 transposase, IS4 family, IS10L YP_002401384.1 284903 R 585055 CDS YP_002401385.1 218693718 7147437 286557..287723 1 NC_011748.1 mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein 287723 7147437 EC55989_0259 Escherichia coli 55989 hypothetical protein YP_002401385.1 286557 D 585055 CDS YP_002401386.1 218693719 7144389 287834..288334 1 NC_011748.1 similar to release factor 1 and 2; peptide chain release factor-like protein 288334 prfH 7144389 prfH Escherichia coli 55989 peptide chain release factor-like protein YP_002401386.1 287834 D 585055 CDS YP_002401387.1 218693720 7147243 complement(288391..289848) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1695895, 21101837, 88121730, 92204123, 2651887; Product type e : enzyme; aminoacyl-histidine dipeptidase 289848 pepD 7147243 pepD Escherichia coli 55989 aminoacyl-histidine dipeptidase YP_002401387.1 288391 R 585055 CDS YP_002401388.1 218693721 7147132 290109..290567 1 NC_011748.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 290567 gpt 7147132 gpt Escherichia coli 55989 xanthine-guanine phosphoribosyltransferase YP_002401388.1 290109 D 585055 CDS YP_002401389.1 218693722 7146364 290659..291903 1 NC_011748.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 291903 frsA 7146364 frsA Escherichia coli 55989 fermentation/respiration switch protein YP_002401389.1 290659 D 585055 CDS YP_002401390.1 218693723 7146194 291961..292362 1 NC_011748.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 292362 crl 7146194 crl Escherichia coli 55989 DNA-binding transcriptional regulator Crl YP_002401390.1 291961 D 585055 CDS YP_002401391.1 218693724 7145757 complement(292401..293456) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89178658, 89380253, 92219258, 98090453, 1380671, 1848301, 1848682, 6089111, 6341601, 7679770; Product type t : transporter; outer membrane phosphoporin protein E 293456 phoE 7145757 phoE Escherichia coli 55989 outer membrane phosphoporin protein E YP_002401391.1 292401 R 585055 CDS YP_002401392.1 218693725 7147181 293744..294847 1 NC_011748.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 294847 proB 7147181 proB Escherichia coli 55989 gamma-glutamyl kinase YP_002401392.1 293744 D 585055 CDS YP_002401393.1 218693726 7147253 294859..296112 1 NC_011748.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 296112 proA 7147253 proA Escherichia coli 55989 gamma-glutamyl phosphate reductase YP_002401393.1 294859 D 585055 CDS YP_002401394.1 218693727 7145361 296469..297683 1 NC_011748.1 prophage CPS-53 integrase 297683 7145361 EC55989_0268 Escherichia coli 55989 prophage CPS-53 integrase YP_002401394.1 296469 D 585055 CDS YP_002401395.1 218693728 7144390 297806..298609 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 298609 7144390 EC55989_0269 Escherichia coli 55989 hypothetical protein YP_002401395.1 297806 D 585055 CDS YP_002401396.1 218693729 7144391 298804..299001 1 NC_011748.1 Phage transcriptional regulator, AlpA 299001 7144391 EC55989_0270 Escherichia coli 55989 Phage transcriptional regulator, AlpA YP_002401396.1 298804 D 585055 CDS YP_002401397.1 218693730 7144392 299080..299880 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pr : regulator; AntA/AntB antirepressor 299880 7144392 EC55989_0271 Escherichia coli 55989 AntA/AntB antirepressor YP_002401397.1 299080 D 585055 CDS YP_002401398.1 218693731 7144393 299873..301459 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 301459 7144393 EC55989_0272 Escherichia coli 55989 hypothetical protein YP_002401398.1 299873 D 585055 CDS YP_002401399.1 218693732 7144394 complement(300598..300903) 1 NC_011748.1 hypothetical protein 300903 7144394 EC55989_0273 Escherichia coli 55989 hypothetical protein YP_002401399.1 300598 R 585055 CDS YP_002401400.1 218693733 7144395 301452..301817 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 301817 7144395 EC55989_0274 Escherichia coli 55989 hypothetical protein YP_002401400.1 301452 D 585055 CDS YP_002401401.1 218693734 7144396 301810..302010 1 NC_011748.1 hypothetical protein 302010 7144396 EC55989_0275 Escherichia coli 55989 hypothetical protein YP_002401401.1 301810 D 585055 CDS YP_002401402.1 218693735 7144397 302015..302305 1 NC_011748.1 hypothetical protein 302305 7144397 EC55989_0276 Escherichia coli 55989 hypothetical protein YP_002401402.1 302015 D 585055 CDS YP_002401403.1 218693736 7144398 302302..304434 1 NC_011748.1 hypothetical protein 304434 7144398 EC55989_0277 Escherichia coli 55989 hypothetical protein YP_002401403.1 302302 D 585055 CDS YP_002401404.1 218693737 7144399 304893..305450 1 NC_011748.1 Activator of ProP osmoprotectant transporter 305450 7144399 EC55989_0278 Escherichia coli 55989 Activator of ProP osmoprotectant transporter YP_002401404.1 304893 D 585055 CDS YP_002401405.1 218693738 7144400 305447..305734 1 NC_011748.1 Protein perC (Protein bfpW) 305734 7144400 EC55989_0279 Escherichia coli 55989 Protein perC (Protein bfpW) YP_002401405.1 305447 D 585055 CDS YP_002401406.1 218693739 7144401 305869..307011 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 307011 7144401 EC55989_0280 Escherichia coli 55989 hypothetical protein YP_002401406.1 305869 D 585055 CDS YP_002401407.1 218693740 7144402 307076..307399 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 307399 7144402 EC55989_0281 Escherichia coli 55989 hypothetical protein YP_002401407.1 307076 D 585055 CDS YP_002401408.1 218693741 7144403 307842..308114 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 308114 7144403 EC55989_0283 Escherichia coli 55989 hypothetical protein YP_002401408.1 307842 D 585055 CDS YP_002401409.1 218693742 7144404 308196..308741 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 308741 7144404 EC55989_0284 Escherichia coli 55989 hypothetical protein YP_002401409.1 308196 D 585055 CDS YP_002401410.1 218693743 7144405 309345..310340 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 310340 7144405 EC55989_0285 Escherichia coli 55989 hypothetical protein YP_002401410.1 309345 D 585055 CDS YP_002401411.1 218693744 7144406 310333..311313 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 311313 7144406 EC55989_0286 Escherichia coli 55989 hypothetical protein YP_002401411.1 310333 D 585055 CDS YP_002401412.1 218693745 7144407 complement(311773..312183) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 312183 yagP 7144407 yagP Escherichia coli 55989 transcriptional regulator YP_002401412.1 311773 R 585055 CDS YP_002401413.1 218693746 7148048 complement(312162..313118) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 313118 yagQ 7148048 yagQ Escherichia coli 55989 hypothetical protein YP_002401413.1 312162 R 585055 CDS YP_002401414.1 218693747 7148049 complement(313128..315326) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase with molybdenum-binding domain 315326 yagR 7148049 yagR Escherichia coli 55989 oxidoreductase with molybdenum-binding domain YP_002401414.1 313128 R 585055 CDS YP_002401415.1 218693748 7148050 complement(315323..316279) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase with FAD-binding domain 316279 yagS 7148050 yagS Escherichia coli 55989 oxidoreductase with FAD-binding domain YP_002401415.1 315323 R 585055 CDS YP_002401416.1 218693749 7148051 complement(316276..316965) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; xanthine dehydrogenase iron-sulfur-binding subunit 316965 yagT 7148051 yagT Escherichia coli 55989 xanthine dehydrogenase iron-sulfur-binding subunit YP_002401416.1 316276 R 585055 CDS YP_002401417.1 218693750 7148052 317383..317997 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 317997 yagU 7148052 yagU Escherichia coli 55989 inner membrane protein YP_002401417.1 317383 D 585055 CDS YP_002401418.1 218693751 7148053 complement(318887..319597) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 319597 yagV 7148053 yagV Escherichia coli 55989 hypothetical protein YP_002401418.1 318887 R 585055 CDS YP_002401419.1 218693752 7148055 complement(319566..321209) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; surface or protein 321209 yagW 7148055 yagW Escherichia coli 55989 surface or protein YP_002401419.1 319566 R 585055 CDS YP_002401420.1 218693753 7148056 complement(321199..323724) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 323724 yagX 7148056 yagX Escherichia coli 55989 hypothetical protein YP_002401420.1 321199 R 585055 CDS YP_002401421.1 218693754 7148057 complement(323750..324418) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 324418 yagY 7148057 yagY Escherichia coli 55989 hypothetical protein YP_002401421.1 323750 R 585055 CDS YP_002401422.1 218693755 7148058 complement(324476..325063) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 17563352, 11466275; Product type s : structure; common pilus ECP 325063 ecpA 7148058 ecpA Escherichia coli 55989 common pilus ECP YP_002401422.1 324476 R 585055 CDS YP_002401423.1 218693756 7145974 complement(325138..325728) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 325728 ykgK 7145974 ykgK Escherichia coli 55989 transcriptional regulator YP_002401423.1 325138 R 585055 CDS YP_002401424.1 218693757 7149243 326503..326730 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 326730 ykgL 7149243 ykgL Escherichia coli 55989 hypothetical protein YP_002401424.1 326503 D 585055 CDS YP_002401425.1 218693758 7149244 complement(326905..327168) 1 NC_011748.1 RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 327168 rpmE2 7149244 rpmE2 Escherichia coli 55989 50S ribosomal protein L31 YP_002401425.1 326905 R 585055 CDS YP_002401426.1 218693759 7149245 328749..333002 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; adhesin 333002 7149245 EC55989_0302 Escherichia coli 55989 adhesin YP_002401426.1 328749 D 585055 CDS YP_002401427.1 218693760 7144408 complement(333123..334013) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; Putatve transcriptional regulator ykgA 334013 ykgA 7144408 ykgA Escherichia coli 55989 Putatve transcriptional regulator ykgA YP_002401427.1 333123 R 585055 CDS YP_002401428.1 218693761 7149234 complement(334570..335163) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 335163 ykgB 7149234 ykgB Escherichia coli 55989 inner membrane protein YP_002401428.1 334570 R 585055 CDS YP_002401429.1 218693762 7149235 complement(335175..335411) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 335411 ykgI 7149235 ykgI Escherichia coli 55989 hypothetical protein YP_002401429.1 335175 R 585055 CDS YP_002401430.1 218693763 7149242 complement(335520..336845) 1 NC_011748.1 Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase 336845 ykgC 7149242 ykgC Escherichia coli 55989 pyridine nucleotide-disulfide oxidoreductase YP_002401430.1 335520 R 585055 CDS YP_002401431.1 218693764 7149236 337071..337925 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; AraC-type DNA-binding transcriptional regulator 337925 ykgD 7149236 ykgD Escherichia coli 55989 AraC-type DNA-binding transcriptional regulator YP_002401431.1 337071 D 585055 CDS YP_002401432.1 218693765 7149237 338452..339171 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydroxyacid oxidoreductase (Fe-S centre) 339171 ykgE 7149237 ykgE Escherichia coli 55989 hydroxyacid oxidoreductase (Fe-S centre) YP_002401432.1 338452 D 585055 CDS YP_002401433.1 218693766 7149238 339182..340609 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase subunit with NAD(P)-binding domain and ferridoxin-like domain 340609 ykgF 7149238 ykgF Escherichia coli 55989 oxidoreductase subunit with NAD(P)-binding domain and ferridoxin-like domain YP_002401433.1 339182 D 585055 CDS YP_002401434.1 218693767 7149239 340602..341297 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 341297 ykgG 7149239 ykgG Escherichia coli 55989 hypothetical protein YP_002401434.1 340602 D 585055 CDS YP_002401435.1 218693768 7149240 complement(341371..341568) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 341568 7149240 EC55989_0311 Escherichia coli 55989 hypothetical protein YP_002401435.1 341371 R 585055 CDS YP_002401436.1 218693769 7144409 complement(341543..342208) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 342208 ykgH 7144409 ykgH Escherichia coli 55989 inner membrane protein YP_002401436.1 341543 R 585055 CDS YP_002401437.1 218693770 7149241 complement(342421..344091) 1 NC_011748.1 catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase 344091 betA 7149241 betA Escherichia coli 55989 choline dehydrogenase YP_002401437.1 342421 R 585055 CDS YP_002401438.1 218693771 7145610 complement(344105..345577) 1 NC_011748.1 catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase 345577 betB 7145610 betB Escherichia coli 55989 betaine aldehyde dehydrogenase YP_002401438.1 344105 R 585055 CDS YP_002401439.1 218693772 7145611 complement(345591..346178) 1 NC_011748.1 HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI 346178 betI 7145611 betI Escherichia coli 55989 transcriptional regulator BetI YP_002401439.1 345591 R 585055 CDS YP_002401440.1 218693773 7145612 346307..348340 1 NC_011748.1 proton-motive-force-driven choline transporter; choline transport protein BetT 348340 betT 7145612 betT Escherichia coli 55989 choline transport protein BetT YP_002401440.1 346307 D 585055 CDS YP_002401441.1 218693774 7145613 348847..352896 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pm : membrane component; AidA-I adhesin-like protein 352896 7145613 EC55989_0317 Escherichia coli 55989 AidA-I adhesin-like protein YP_002401441.1 348847 D 585055 CDS YP_002401442.1 218693775 7144410 353038..354126 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15995192; Product type e : enzyme; cyclic di-GMP phosphodiesterase 354126 yahA 7144410 yahA Escherichia coli 55989 cyclic di-GMP phosphodiesterase YP_002401442.1 353038 D 585055 CDS YP_002401443.1 218693776 7148059 complement(354168..355100) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 355100 yahB 7148059 yahB Escherichia coli 55989 DNA-binding transcriptional regulator YP_002401443.1 354168 R 585055 CDS YP_002401444.1 218693777 7148060 complement(355192..355689) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 355689 yahC 7148060 yahC Escherichia coli 55989 inner membrane protein YP_002401444.1 355192 R 585055 CDS YP_002401445.1 218693778 7148061 355947..356552 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; protein with ankyrin domain 356552 yahD 7148061 yahD Escherichia coli 55989 protein with ankyrin domain YP_002401445.1 355947 D 585055 CDS YP_002401446.1 218693779 7148062 356592..357455 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 357455 yahE 7148062 yahE Escherichia coli 55989 hypothetical protein YP_002401446.1 356592 D 585055 CDS YP_002401447.1 218693780 7148063 357445..358992 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; enzyme with acyl-CoA domain 358992 yahF 7148063 yahF Escherichia coli 55989 enzyme with acyl-CoA domain YP_002401447.1 357445 D 585055 CDS YP_002401448.1 218693781 7148064 358992..360410 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 360410 yahG 7148064 yahG Escherichia coli 55989 hypothetical protein YP_002401448.1 358992 D 585055 CDS YP_002401449.1 218693782 7148065 360553..361503 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7711027, 11523892; Product type pe : enzyme; carbamate kinase 361503 yahI 7148065 yahI Escherichia coli 55989 carbamate kinase YP_002401449.1 360553 D 585055 CDS YP_002401450.1 218693783 7148066 361513..362895 1 NC_011748.1 metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; deaminase 362895 yahJ 7148066 yahJ Escherichia coli 55989 deaminase YP_002401450.1 361513 D 585055 CDS YP_002401451.1 218693784 7148067 363164..363604 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 363604 7148067 EC55989_0327 Escherichia coli 55989 hypothetical protein YP_002401451.1 363164 D 585055 CDS YP_002401452.1 218693785 7144411 363855..364841 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; periplasmic binding protein, substrate ribose (sugar-binding protein), ABC-type transport system 364841 7144411 EC55989_0328 Escherichia coli 55989 periplasmic binding protein, substrate ribose (sugar-binding protein), ABC-type transport system YP_002401452.1 363855 D 585055 CDS YP_002401453.1 218693786 7144412 364875..366374 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; ATP-binding component of ABC sugar transport system 366374 7144412 EC55989_0329 Escherichia coli 55989 ATP-binding component of ABC sugar transport system YP_002401453.1 364875 D 585055 CDS YP_002401454.1 218693787 7144413 366367..367338 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; permease component of sugar ABC transport system 367338 7144413 EC55989_0330 Escherichia coli 55989 permease component of sugar ABC transport system YP_002401454.1 366367 D 585055 CDS YP_002401455.1 218693788 7144414 367305..368291 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; permease component of sugar ABC transport system 368291 7144414 EC55989_0331 Escherichia coli 55989 permease component of sugar ABC transport system YP_002401455.1 367305 D 585055 CDS YP_002401456.1 218693789 7144415 368378..369427 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase, Zn-dependent and NAD(P)-binding 369427 yahK 7144415 yahK Escherichia coli 55989 oxidoreductase, Zn-dependent and NAD(P)-binding YP_002401456.1 368378 D 585055 CDS YP_002401457.1 218693790 7148068 369670..370485 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 370485 yahL 7148068 yahL Escherichia coli 55989 hypothetical protein YP_002401457.1 369670 D 585055 CDS YP_002401458.1 218693791 7145372 370897..371142 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 371142 yahM 7145372 yahM Escherichia coli 55989 hypothetical protein YP_002401458.1 370897 D 585055 CDS YP_002401459.1 218693792 7148070 complement(371159..371830) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12879215; Product type t : transporter; neutral amino-acid efflux system 371830 yahN 7148070 yahN Escherichia coli 55989 neutral amino-acid efflux system YP_002401459.1 371159 R 585055 CDS YP_002401460.1 218693793 7148071 371977..372252 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 372252 yahO 7148071 yahO Escherichia coli 55989 hypothetical protein YP_002401460.1 371977 D 585055 CDS YP_002401461.1 218693794 7148072 complement(372353..373939) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9325432, 15805526; Product type r : regulator; DNA-binding transcriptional activator 373939 prpR 7148072 prpR Escherichia coli 55989 DNA-binding transcriptional activator YP_002401461.1 372353 R 585055 CDS YP_002401462.1 218693795 7147266 374177..375067 1 NC_011748.1 catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 375067 prpB 7147266 prpB Escherichia coli 55989 2-methylisocitrate lyase YP_002401462.1 374177 D 585055 CDS YP_002401463.1 218693796 7147262 375112..376281 1 NC_011748.1 catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 376281 prpC 7147262 prpC Escherichia coli 55989 methylcitrate synthase YP_002401463.1 375112 D 585055 CDS YP_002401464.1 218693797 7147263 376315..377766 1 NC_011748.1 functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 377766 prpD 7147263 prpD Escherichia coli 55989 2-methylcitrate dehydratase YP_002401464.1 376315 D 585055 CDS YP_002401465.1 218693798 7147264 377806..379692 1 NC_011748.1 catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 379692 prpE 7147264 prpE Escherichia coli 55989 propionyl-CoA synthetase YP_002401465.1 377806 D 585055 CDS YP_002401466.1 218693799 7147265 380155..381135 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 381135 7147265 EC55989_0342 Escherichia coli 55989 transposase, IS110 family YP_002401466.1 380155 D 585055 CDS YP_002401467.1 218693800 7144416 381397..382656 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92349961; Product type t : transporter; cytosine permease 382656 codB 7144416 codB Escherichia coli 55989 cytosine permease YP_002401467.1 381397 D 585055 CDS YP_002401468.1 218693801 7145740 382646..383929 1 NC_011748.1 Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 383929 codA 7145740 codA Escherichia coli 55989 cytosine deaminase YP_002401468.1 382646 D 585055 CDS YP_002401469.1 218693802 7145739 complement(383969..384868) 1 NC_011748.1 controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source; DNA-binding transcriptional regulator CynR 384868 cynR 7145739 cynR Escherichia coli 55989 DNA-binding transcriptional regulator CynR YP_002401469.1 383969 R 585055 CDS YP_002401470.1 218693803 7145811 384978..385637 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91242169, 92156106, 94075239, 3049588; Product type e : enzyme; carbonic anhydrase 385637 cynT 7145811 cynT Escherichia coli 55989 carbonic anhydrase YP_002401470.1 384978 D 585055 CDS YP_002401471.1 218693804 7145813 385668..386138 1 NC_011748.1 catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 386138 cynS 7145813 cynS Escherichia coli 55989 cyanate hydratase YP_002401471.1 385668 D 585055 CDS YP_002401472.1 218693805 7145812 386171..387325 1 NC_011748.1 MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential; cyanate transporter 387325 cynX 7145812 cynX Escherichia coli 55989 cyanate transporter YP_002401472.1 386171 D 585055 CDS YP_002401473.1 218693806 7145814 complement(387428..388039) 1 NC_011748.1 transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown; galactoside O-acetyltransferase 388039 lacA 7145814 lacA Escherichia coli 55989 galactoside O-acetyltransferase YP_002401473.1 387428 R 585055 CDS YP_002401474.1 218693807 7146675 complement(388105..389358) 1 NC_011748.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 389358 lacY 7146675 lacY Escherichia coli 55989 galactoside permease YP_002401474.1 388105 R 585055 CDS YP_002401475.1 218693808 7146677 complement(389410..392484) 1 NC_011748.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase 392484 lacZ 7146677 lacZ Escherichia coli 55989 beta-D-galactosidase YP_002401475.1 389410 R 585055 CDS YP_002401476.1 218693809 7146678 complement(392607..393689) 1 NC_011748.1 transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor 393689 lacI 7146678 lacI Escherichia coli 55989 lac repressor YP_002401476.1 392607 R 585055 CDS YP_002401477.1 218693810 7146676 complement(393766..394713) 1 NC_011748.1 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional activator MhpR 394713 mhpR 7146676 mhpR Escherichia coli 55989 DNA-binding transcriptional activator MhpR YP_002401477.1 393766 R 585055 CDS YP_002401478.1 218693811 7146850 394790..396454 1 NC_011748.1 catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 396454 mhpA 7146850 mhpA Escherichia coli 55989 3-(3-hydroxyphenyl)propionate hydroxylase YP_002401478.1 394790 D 585055 CDS YP_002401479.1 218693812 7146844 396456..397400 1 NC_011748.1 catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 397400 mhpB 7146844 mhpB Escherichia coli 55989 3-(2,3-dihydroxyphenyl)propionate dioxygenase YP_002401479.1 396456 D 585055 CDS YP_002401480.1 218693813 7146845 397403..398284 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87008429, 94002258, 15663942; Product type e : enzyme; 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 398284 mhpC 7146845 mhpC Escherichia coli 55989 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase YP_002401480.1 397403 D 585055 CDS YP_002401481.1 218693814 7146846 398294..399103 1 NC_011748.1 catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 399103 mhpD 7146846 mhpD Escherichia coli 55989 2-keto-4-pentenoate hydratase YP_002401481.1 398294 D 585055 CDS YP_002401482.1 218693815 7146847 399100..400050 1 NC_011748.1 catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 400050 mhpF 7146847 mhpF Escherichia coli 55989 acetaldehyde dehydrogenase YP_002401482.1 399100 D 585055 CDS YP_002401483.1 218693816 7146849 400047..401060 1 NC_011748.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 401060 mhpE 7146849 mhpE Escherichia coli 55989 4-hydroxy-2-ketovalerate aldolase YP_002401483.1 400047 D 585055 CDS YP_002401484.1 218693817 7146848 401236..402447 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7961399; Product type t : transporter; 3-hydroxyphenylpropionic transporter MhpT 402447 mhpT 7146848 mhpT Escherichia coli 55989 3-hydroxyphenylpropionic transporter MhpT YP_002401484.1 401236 D 585055 CDS YP_002401485.1 218693818 7146851 402549..403088 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15115803, 12878731, 13129938; Product type e : enzyme; nucleoprotein/polynucleotide-associated enzyme 403088 yaiL 7146851 yaiL Escherichia coli 55989 nucleoprotein/polynucleotide-associated enzyme YP_002401485.1 402549 D 585055 CDS YP_002401486.1 218693819 7148078 403338..404318 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 404318 7148078 EC55989_0363 Escherichia coli 55989 transposase, IS110 family YP_002401486.1 403338 D 585055 CDS YP_002401487.1 218693820 7144417 complement(404593..405426) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800, 15466022; Product type e : enzyme; S-formylglutathione hydrolase 405426 frmB 7144417 frmB Escherichia coli 55989 S-formylglutathione hydrolase YP_002401487.1 404593 R 585055 CDS YP_002401488.1 218693821 7146190 complement(405519..406628) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15466022, 87172301, 1731906; Product type e : enzyme; alcohol dehydrogenase 406628 frmA 7146190 frmA Escherichia coli 55989 alcohol dehydrogenase YP_002401488.1 405519 R 585055 CDS YP_002401489.1 218693822 7146189 complement(406663..406938) 1 NC_011748.1 formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR 406938 frmR 7146189 frmR Escherichia coli 55989 regulator protein FrmR YP_002401489.1 406663 R 585055 CDS YP_002401490.1 218693823 7146192 complement(407124..407897) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 407897 yaiO 7146192 yaiO Escherichia coli 55989 hypothetical protein YP_002401490.1 407124 R 585055 CDS YP_002401491.1 218693824 7148079 complement(407899..408609) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transferase 408609 yaiX 7148079 yaiX Escherichia coli 55989 transferase YP_002401491.1 407899 R 585055 CDS YP_002401492.1 218693825 7148084 complement(408458..409654) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane-associated glycosyltransferase 409654 yaiP 7148084 yaiP Escherichia coli 55989 membrane-associated glycosyltransferase YP_002401492.1 408458 R 585055 CDS YP_002401493.1 218693826 7148080 complement(409664..410335) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 410335 yaiS 7148080 yaiS Escherichia coli 55989 hypothetical protein YP_002401493.1 409664 R 585055 CDS YP_002401494.1 218693827 7148081 410951..411913 1 NC_011748.1 with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 411913 tauA 7148081 tauA Escherichia coli 55989 taurine transporter substrate binding subunit YP_002401494.1 410951 D 585055 CDS YP_002401495.1 218693828 7147758 411926..412693 1 NC_011748.1 Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 412693 tauB 7147758 tauB Escherichia coli 55989 taurine transporter ATP-binding subunit YP_002401495.1 411926 D 585055 CDS YP_002401496.1 218693829 7147759 412690..413517 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401024, 96404792; Product type t : transporter; taurine transporter subunit 413517 tauC 7147759 tauC Escherichia coli 55989 taurine transporter subunit YP_002401496.1 412690 D 585055 CDS YP_002401497.1 218693830 7147760 413514..414365 1 NC_011748.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 414365 tauD 7147760 tauD Escherichia coli 55989 taurine dioxygenase YP_002401497.1 413514 D 585055 CDS YP_002401498.1 218693831 7147761 complement(414471..415445) 1 NC_011748.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase 415445 hemB 7147761 hemB Escherichia coli 55989 delta-aminolevulinic acid dehydratase YP_002401498.1 414471 R 585055 CDS YP_002401499.1 218693832 7146408 415969..418857 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; flagellin structural protein; protein 418857 7146408 EC55989_0378 Escherichia coli 55989 flagellin structural protein; protein YP_002401499.1 415969 D 585055 CDS YP_002401500.1 218693833 7144418 418900..419568 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; DNA-binding transcriptional regulator 419568 yaiV 7144418 yaiV Escherichia coli 55989 DNA-binding transcriptional regulator YP_002401500.1 418900 D 585055 CDS YP_002401501.1 218693834 7148082 complement(419569..420726) 1 NC_011748.1 this protein has no known enzymatic function; beta-lactam binding protein AmpH 420726 ampH 7148082 ampH Escherichia coli 55989 beta-lactam binding protein AmpH YP_002401501.1 419569 R 585055 CDS YP_002401502.1 218693835 7145498 420864..421058 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 421058 7145498 EC55989_0381 Escherichia coli 55989 hypothetical protein YP_002401502.1 420864 D 585055 CDS YP_002401503.1 218693836 7144419 421078..422298 1 NC_011748.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transporter 422298 sbmA 7144419 sbmA Escherichia coli 55989 transporter YP_002401503.1 421078 D 585055 CDS YP_002401504.1 218693837 7147609 422311..423405 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; lipoprotein 423405 yaiW 7147609 yaiW Escherichia coli 55989 lipoprotein YP_002401504.1 422311 D 585055 CDS YP_002401505.1 218693838 7148083 complement(423464..423772) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 423772 yaiY 7148083 yaiY Escherichia coli 55989 inner membrane protein YP_002401505.1 423464 R 585055 CDS YP_002401506.1 218693839 7148085 423900..424244 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 424244 yaiZ 7148085 yaiZ Escherichia coli 55989 hypothetical protein YP_002401506.1 423900 D 585055 CDS YP_002401507.1 218693840 7148086 complement(424268..425362) 1 NC_011748.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A 425362 ddl 7148086 ddl Escherichia coli 55989 D-alanyl-alanine synthetase A YP_002401507.1 424268 R 585055 CDS YP_002401508.1 218693841 7145867 425440..425643 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 425643 7145867 EC55989_0387 Escherichia coli 55989 hypothetical protein YP_002401508.1 425440 D 585055 CDS YP_002401509.1 218693842 7144420 425825..426085 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 426085 yaiB 7144420 yaiB Escherichia coli 55989 hypothetical protein YP_002401509.1 425825 D 585055 CDS YP_002401510.1 218693843 7147178 complement(426499..427002) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 427002 insB 7147178 insB Escherichia coli 55989 IS1 transposase InsAB' YP_002401510.1 426499 R 585055 CDS YP_002401511.1 218693844 7146580 complement(426921..427196) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 427196 insA 7146580 insA Escherichia coli 55989 IS1 repressor protein InsA YP_002401511.1 426921 R 585055 CDS YP_002401512.1 218693845 7147179 428497..428817 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3533724, 2160940; Product type f : factor; hypothetical protein 428817 psiF 7147179 psiF Escherichia coli 55989 hypothetical protein YP_002401512.1 428497 D 585055 CDS YP_002401513.1 218693846 7147269 428919..430034 1 NC_011748.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 430034 adrA 7147269 adrA Escherichia coli 55989 diguanylate cyclase AdrA YP_002401513.1 428919 D 585055 CDS YP_002401514.1 218693847 7148075 complement(430051..430860) 1 NC_011748.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase 430860 proC 7148075 proC Escherichia coli 55989 pyrroline-5-carboxylate reductase YP_002401514.1 430051 R 585055 CDS YP_002401515.1 218693848 7147254 430980..431438 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 431438 yaiI 7147254 yaiI Escherichia coli 55989 hypothetical protein YP_002401515.1 430980 D 585055 CDS YP_002401516.1 218693849 7148077 431621..432145 1 NC_011748.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 432145 aroL 7148077 aroL Escherichia coli 55989 shikimate kinase YP_002401516.1 431621 D 585055 CDS YP_002401517.1 218693850 7145548 432195..432386 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 432386 yaiA 7145548 yaiA Escherichia coli 55989 hypothetical protein YP_002401517.1 432195 D 585055 CDS YP_002401518.1 218693851 7148073 432644..433321 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 86085675, 3001025; hypothetical protein 433321 aroM 7148073 aroM Escherichia coli 55989 hypothetical protein YP_002401518.1 432644 D 585055 CDS YP_002401519.1 218693852 7145549 433393..433677 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 433677 yaiE 7145549 yaiE Escherichia coli 55989 hypothetical protein YP_002401519.1 433393 D 585055 CDS YP_002401520.1 218693853 7148076 433938..434300 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 434300 7148076 EC55989_0401 Escherichia coli 55989 hypothetical protein YP_002401520.1 433938 D 585055 CDS YP_002401521.1 218693854 7144421 complement(434378..435289) 1 NC_011748.1 Required for efficient pilin antigenic variation; recombination associated protein 435289 rdgC 7144421 rdgC Escherichia coli 55989 recombination associated protein YP_002401521.1 434378 R 585055 CDS YP_002401522.1 218693855 7147352 435414..436322 1 NC_011748.1 catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 436322 mak 7147352 mak Escherichia coli 55989 fructokinase YP_002401522.1 435414 D 585055 CDS YP_002401523.1 218693856 7146767 complement(436465..437649) 1 NC_011748.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ 437649 araJ 7146767 araJ Escherichia coli 55989 MFS transport protein AraJ YP_002401523.1 436465 R 585055 CDS YP_002401524.1 218693857 7145521 complement(437775..440918) 1 NC_011748.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease SbcC 440918 sbcC 7145521 sbcC Escherichia coli 55989 exonuclease SbcC YP_002401524.1 437775 R 585055 CDS YP_002401525.1 218693858 7147607 complement(440915..442117) 1 NC_011748.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease SbcD 442117 sbcD 7147607 sbcD Escherichia coli 55989 exonuclease SbcD YP_002401525.1 440915 R 585055 CDS YP_002401526.1 218693859 7147608 442307..442996 1 NC_011748.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 442996 phoB 7147608 phoB Escherichia coli 55989 transcriptional regulator PhoB YP_002401526.1 442307 D 585055 CDS YP_002401527.1 218693860 7147180 443054..444349 1 NC_011748.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 444349 phoR 7147180 phoR Escherichia coli 55989 phosphate regulon sensor protein YP_002401527.1 443054 D 585055 CDS YP_002401528.1 218693861 7147185 complement(444360..444470) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 444470 7147185 EC55989_0409 Escherichia coli 55989 hypothetical protein YP_002401528.1 444360 R 585055 CDS YP_002401529.1 218693862 7144422 444756..446075 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3078876, 6998958, 3550103, 7984428; Product type t : transporter; branched chain amino acid transporter (LIV-II) 446075 brnQ 7144422 brnQ Escherichia coli 55989 branched chain amino acid transporter (LIV-II) YP_002401529.1 444756 D 585055 CDS YP_002401530.1 218693863 7145636 446151..447524 1 NC_011748.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; proline-specific permease 447524 proY 7145636 proY Escherichia coli 55989 proline-specific permease YP_002401530.1 446151 D 585055 CDS YP_002401531.1 218693864 7147261 447680..449497 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92184757, 1706703, 1918057; Product type e : enzyme; maltodextrin glucosidase 449497 malZ 7147261 malZ Escherichia coli 55989 maltodextrin glucosidase YP_002401531.1 447680 D 585055 CDS YP_002401532.1 218693865 7146780 complement(449502..450083) 1 NC_011748.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; ACP phosphodieterase 450083 acpH 7146780 acpH Escherichia coli 55989 ACP phosphodieterase YP_002401532.1 449502 R 585055 CDS YP_002401533.1 218693866 7145440 450176..451246 1 NC_011748.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 451246 queA 7145440 queA Escherichia coli 55989 S-adenosylmethionine--tRNA ribosyltransferase-isomerase YP_002401533.1 450176 D 585055 CDS YP_002401534.1 218693867 7147331 451302..452429 1 NC_011748.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 452429 tgt 7147331 tgt Escherichia coli 55989 queuine tRNA-ribosyltransferase YP_002401534.1 451302 D 585055 CDS YP_002401535.1 218693868 7147781 452452..452784 1 NC_011748.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 452784 yajC 7147781 yajC Escherichia coli 55989 preprotein translocase subunit YajC YP_002401535.1 452452 D 585055 CDS YP_002401536.1 218693869 7148087 452812..454659 1 NC_011748.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 454659 secD 7148087 secD Escherichia coli 55989 preprotein translocase subunit SecD YP_002401536.1 452812 D 585055 CDS YP_002401537.1 218693870 7147622 454670..455641 1 NC_011748.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 455641 secF 7147622 secF Escherichia coli 55989 preprotein translocase subunit SecF YP_002401537.1 454670 D 585055 CDS YP_002401538.1 218693871 7147624 455770..456117 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 456117 yajD 7147624 yajD Escherichia coli 55989 hypothetical protein YP_002401538.1 455770 D 585055 CDS YP_002401539.1 218693872 7148088 complement(456294..457178) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91092502, 91358319, 93352541; Product type m : membrane component; nucleoside channel phage T6/colicin K receptor 457178 tsx 7148088 tsx Escherichia coli 55989 nucleoside channel phage T6/colicin K receptor YP_002401539.1 456294 R 585055 CDS YP_002401540.1 218693873 7144423 458167..458616 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator NrdR 458616 nrdR 7144423 nrdR Escherichia coli 55989 transcriptional regulator NrdR YP_002401540.1 458167 D 585055 CDS YP_002401541.1 218693874 7147026 458620..459723 1 NC_011748.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 459723 ribD 7147026 ribD Escherichia coli 55989 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase YP_002401541.1 458620 D 585055 CDS YP_002401542.1 218693875 7147412 459812..460282 1 NC_011748.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 460282 ribH 7147412 ribH Escherichia coli 55989 6,7-dimethyl-8-ribityllumazine synthase YP_002401542.1 459812 D 585055 CDS YP_002401543.1 218693876 7147413 460302..460721 1 NC_011748.1 Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 460721 nusB 7147413 nusB Escherichia coli 55989 transcription antitermination protein NusB YP_002401543.1 460302 D 585055 CDS YP_002401544.1 218693877 7147059 460799..461776 1 NC_011748.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 461776 thiL 7147059 thiL Escherichia coli 55989 thiamine monophosphate kinase YP_002401544.1 460799 D 585055 CDS YP_002401545.1 218693878 7147789 461754..462272 1 NC_011748.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 462272 pgpA 7147789 pgpA Escherichia coli 55989 phosphatidylglycerophosphatase A YP_002401545.1 461754 D 585055 CDS YP_002401546.1 218693879 7147154 complement(462326..463300) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217, 16077126; Product type e : enzyme; aldoketo-oxidoreductase 463300 yajO 7147154 yajO Escherichia coli 55989 aldoketo-oxidoreductase YP_002401546.1 462326 R 585055 CDS YP_002401547.1 218693880 7148092 complement(463355..465217) 1 NC_011748.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase 465217 dxs 7148092 dxs Escherichia coli 55989 1-deoxy-D-xylulose-5-phosphate synthase YP_002401547.1 463355 R 585055 CDS YP_002401548.1 218693881 7145964 complement(465242..466141) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89291702, 91210228; Product type e : enzyme; geranyltranstransferase 466141 ispA 7145964 ispA Escherichia coli 55989 geranyltranstransferase YP_002401548.1 465242 R 585055 CDS YP_002401549.1 218693882 7146625 complement(466141..466383) 1 NC_011748.1 catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit 466383 xseB 7146625 xseB Escherichia coli 55989 exodeoxyribonuclease VII small subunit YP_002401549.1 466141 R 585055 CDS YP_002401550.1 218693883 7147993 466589..468037 1 NC_011748.1 Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 468037 thiI 7147993 thiI Escherichia coli 55989 thiamine biosynthesis protein ThiI YP_002401550.1 466589 D 585055 CDS YP_002401551.1 218693884 7147788 complement(468091..468681) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 97039868, 99173753, 99311269; DJ-1 family protein 468681 yajL 7147788 yajL Escherichia coli 55989 DJ-1 family protein YP_002401551.1 468091 R 585055 CDS YP_002401552.1 218693885 7148091 complement(468644..469555) 1 NC_011748.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase 469555 panE 7148091 panE Escherichia coli 55989 2-dehydropantoate 2-reductase YP_002401552.1 468644 R 585055 CDS YP_002401553.1 218693886 7147113 469723..470214 1 NC_011748.1 nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 470214 yajQ 7147113 yajQ Escherichia coli 55989 nucleotide-binding protein YP_002401553.1 469723 D 585055 CDS YP_002401554.1 218693887 7148093 complement(470342..471706) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; major facilitator family transporter 471706 yajR 7148093 yajR Escherichia coli 55989 major facilitator family transporter YP_002401554.1 470342 R 585055 CDS YP_002401555.1 218693888 7148094 472054..473049 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; zinc-dependent hydrolase 473049 7148094 EC55989_0439 Escherichia coli 55989 zinc-dependent hydrolase YP_002401555.1 472054 D 585055 CDS YP_002401556.1 218693889 7144424 complement(473105..473647) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acetyltransferase 473647 7144424 EC55989_0440 Escherichia coli 55989 acetyltransferase YP_002401556.1 473105 R 585055 CDS YP_002401557.1 218693890 7144425 complement(473631..474008) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 474008 7144425 EC55989_0441 Escherichia coli 55989 hypothetical protein YP_002401557.1 473631 R 585055 CDS YP_002401558.1 218693891 7144426 complement(474127..475017) 1 NC_011748.1 converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase 475017 cyoE 7144426 cyoE Escherichia coli 55989 protoheme IX farnesyltransferase YP_002401558.1 474127 R 585055 CDS YP_002401559.1 218693892 7145819 complement(475029..475358) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 90366572, 92345252, 9378722, 98021084, 11017202, 2162835; Product type c : carrier; cytochrome o ubiquinol oxidase subunit IV 475358 cyoD 7145819 cyoD Escherichia coli 55989 cytochrome o ubiquinol oxidase subunit IV YP_002401559.1 475029 R 585055 CDS YP_002401560.1 218693893 7145818 complement(475358..475972) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit III 475972 cyoC 7145818 cyoC Escherichia coli 55989 cytochrome o ubiquinol oxidase subunit III YP_002401560.1 475358 R 585055 CDS YP_002401561.1 218693894 7145817 complement(475962..477953) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit I 477953 cyoB 7145817 cyoB Escherichia coli 55989 cytochrome o ubiquinol oxidase subunit I YP_002401561.1 475962 R 585055 CDS YP_002401562.1 218693895 7145816 complement(477975..478922) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92112945, 92371427, 9378722, 98021084, 11017202, 1322173, 2162835, 2162837, 2165491, 2168206, 8231804, 8618822; Product type c : carrier; cytochrome o ubiquinol oxidase subunit II 478922 cyoA 7145816 cyoA Escherichia coli 55989 cytochrome o ubiquinol oxidase subunit II YP_002401562.1 477975 R 585055 CDS YP_002401563.1 218693896 7145815 complement(479382..480857) 1 NC_011748.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter 480857 ampG 7145815 ampG Escherichia coli 55989 muropeptide transporter YP_002401563.1 479382 R 585055 CDS YP_002401564.1 218693897 7145497 complement(480901..481479) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 481479 yajG 7145497 yajG Escherichia coli 55989 hypothetical protein YP_002401564.1 480901 R 585055 CDS YP_002401565.1 218693898 7148089 481784..482101 1 NC_011748.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 482101 bolA 7148089 bolA Escherichia coli 55989 transcriptional regulator BolA YP_002401565.1 481784 D 585055 CDS YP_002401566.1 218693899 7145635 482445..483743 1 NC_011748.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 483743 tig 7145635 tig Escherichia coli 55989 trigger factor YP_002401566.1 482445 D 585055 CDS YP_002401567.1 218693900 7147801 483989..484612 1 NC_011748.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 484612 clpP 7147801 clpP Escherichia coli 55989 ATP-dependent Clp protease proteolytic subunit YP_002401567.1 483989 D 585055 CDS YP_002401568.1 218693901 7145724 484738..486012 1 NC_011748.1 binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 486012 clpX 7145724 clpX Escherichia coli 55989 ATP-dependent protease ATP-binding subunit ClpX YP_002401568.1 484738 D 585055 CDS YP_002401569.1 218693902 7147698 486200..488554 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094703, 14665623, 8939438, 91072263, 97137085, 2984174, 3042779, 3289547, 7988699, 8226758, 8294008; Product type e : enzyme; DNA-binding ATP-dependent protease La 488554 lon 7147698 lon Escherichia coli 55989 DNA-binding ATP-dependent protease La YP_002401569.1 486200 D 585055 CDS YP_002401570.1 218693903 7146720 488763..489035 1 NC_011748.1 histone-like DNA-binding protein; transcriptional regulator HU subunit beta 489035 hupB 7146720 hupB Escherichia coli 55989 transcriptional regulator HU subunit beta YP_002401570.1 488763 D 585055 CDS YP_002401571.1 218693904 7146481 489227..491098 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9670013; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase 491098 ppiD 7146481 ppiD Escherichia coli 55989 peptidyl-prolyl cis-trans isomerase YP_002401571.1 489227 D 585055 CDS YP_002401572.1 218693905 7147231 491249..491620 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 491620 ybaV 7147231 ybaV Escherichia coli 55989 hypothetical protein YP_002401572.1 491249 D 585055 CDS YP_002401573.1 218693906 7148108 491714..492112 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 492112 ybaW 7148108 ybaW Escherichia coli 55989 hypothetical protein YP_002401573.1 491714 D 585055 CDS YP_002401574.1 218693907 7148109 complement(492164..492859) 1 NC_011748.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC 492859 queC 7148109 queC Escherichia coli 55989 queuosine biosynthesis protein QueC YP_002401574.1 492164 R 585055 CDS YP_002401575.1 218693908 7147332 complement(492924..494624) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 494624 ybaE 7147332 ybaE Escherichia coli 55989 hypothetical protein YP_002401575.1 492924 R 585055 CDS YP_002401576.1 218693909 7148097 494724..495542 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; thiamin pyrimidine pyrophosphate hydrolase 495542 cof 7148097 cof Escherichia coli 55989 thiamin pyrimidine pyrophosphate hydrolase YP_002401576.1 494724 D 585055 CDS YP_002401577.1 218693910 7145741 495467..496153 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator (Lrp-like) 496153 ybaO 7145741 ybaO Escherichia coli 55989 DNA-binding transcriptional regulator (Lrp-like) YP_002401577.1 495467 D 585055 CDS YP_002401578.1 218693911 7148103 496183..497955 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004, 10850996; Product type pt : transporter; multidrug transporter membrane\ATP-binding components 497955 mdlA 7148103 mdlA Escherichia coli 55989 multidrug transporter membrane\ATP-binding components YP_002401578.1 496183 D 585055 CDS YP_002401579.1 218693912 7146795 497948..499729 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004; Product type pt : transporter; multidrug transporter membrane\ATP-binding components 499729 mdlB 7146795 mdlB Escherichia coli 55989 multidrug transporter membrane\ATP-binding components YP_002401579.1 497948 D 585055 CDS YP_002401580.1 218693913 7146796 499910..500248 1 NC_011748.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 500248 glnK 7146796 glnK Escherichia coli 55989 nitrogen regulatory protein P-II 2 YP_002401580.1 499910 D 585055 CDS YP_002401581.1 218693914 7146308 500278..501564 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22020597, 9618533, 10931328, 1645722, 7984428; Product type t : transporter; ammonium transporter 501564 amtB 7146308 amtB Escherichia coli 55989 ammonium transporter YP_002401581.1 500278 D 585055 CDS YP_002401582.1 218693915 7145499 complement(501613..502473) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86139906, 91250410, 10876240; Product type e : enzyme; acyl-CoA thioesterase 502473 tesB 7145499 tesB Escherichia coli 55989 acyl-CoA thioesterase YP_002401582.1 501613 R 585055 CDS YP_002401583.1 218693916 7147776 502691..503263 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; lipoprotein 503263 ybaY 7147776 ybaY Escherichia coli 55989 lipoprotein YP_002401583.1 502691 D 585055 CDS YP_002401584.1 218693917 7148110 complement(503294..503683) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; methylated DNA-protein cysteine alkyltransferase 503683 ybaZ 7148110 ybaZ Escherichia coli 55989 methylated DNA-protein cysteine alkyltransferase YP_002401584.1 503294 R 585055 CDS YP_002401585.1 218693918 7146096 503984..504337 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 504337 ybaA 7146096 ybaA Escherichia coli 55989 hypothetical protein YP_002401585.1 503984 D 585055 CDS YP_002401586.1 218693919 7148095 complement(504379..505929) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 505929 ylaB 7148095 ylaB Escherichia coli 55989 inner membrane protein YP_002401586.1 504379 R 585055 CDS YP_002401587.1 218693920 7149246 complement(506093..506563) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 506563 ylaC 7149246 ylaC Escherichia coli 55989 inner membrane protein YP_002401587.1 506093 R 585055 CDS YP_002401588.1 218693921 7149247 complement(506679..507230) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82180540, 91310703, 9600841; Product type e : enzyme; maltose O-acetyltransferase 507230 maa 7149247 maa Escherichia coli 55989 maltose O-acetyltransferase YP_002401588.1 506679 R 585055 CDS YP_002401589.1 218693922 7146763 complement(507401..507865) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1956303, 1484495; Product type f : factor; modulator of gene expression, with H-NS 507865 hha 7146763 hha Escherichia coli 55989 modulator of gene expression, with H-NS YP_002401589.1 507401 R 585055 CDS YP_002401590.1 218693923 7146426 complement(507645..508019) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1956303, 7984428, 14645275; hypothetical protein 508019 ybaJ 7146426 ybaJ Escherichia coli 55989 hypothetical protein YP_002401590.1 507645 R 585055 CDS YP_002401591.1 218693924 7148098 complement(508565..511714) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12351840, 12654283, 15111118, 15155734, 21450803, 94012493, 10920254, 7651136; Product type t : transporter; multidrug efflux system protein 511714 acrB 7148098 acrB Escherichia coli 55989 multidrug efflux system protein YP_002401591.1 508565 R 585055 CDS YP_002401592.1 218693925 7145445 complement(511737..512930) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155734, 21450803, 383699, 390095, 94012493, 10920254, 7651136; Product type t : transporter; multidrug efflux system 512930 acrA 7145445 acrA Escherichia coli 55989 multidrug efflux system YP_002401592.1 511737 R 585055 CDS YP_002401593.1 218693926 7145444 513072..513719 1 NC_011748.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 513719 acrR 7145444 acrR Escherichia coli 55989 DNA-binding transcriptional repressor AcrR YP_002401593.1 513072 D 585055 CDS YP_002401594.1 218693927 7145449 513847..517209 1 NC_011748.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 517209 kefA 7145449 kefA Escherichia coli 55989 potassium efflux protein KefA YP_002401594.1 513847 D 585055 CDS YP_002401595.1 218693928 7146666 complement(517421..517582) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 517582 ybaM 7146666 ybaM Escherichia coli 55989 hypothetical protein YP_002401595.1 517421 R 585055 CDS YP_002401596.1 218693929 7148101 complement(517596..518123) 1 NC_011748.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' 518123 priC 7148101 priC Escherichia coli 55989 primosomal replication protein N'' YP_002401596.1 517596 R 585055 CDS YP_002401597.1 218693930 7147246 518193..518570 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 518570 ybaN 7147246 ybaN Escherichia coli 55989 hypothetical protein YP_002401597.1 518193 D 585055 CDS YP_002401598.1 218693931 7148102 518723..519274 1 NC_011748.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 519274 apt 7148102 apt Escherichia coli 55989 adenine phosphoribosyltransferase YP_002401598.1 518723 D 585055 CDS YP_002401599.1 218693932 7145511 519403..521334 1 NC_011748.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 521334 dnaX 7145511 dnaX Escherichia coli 55989 DNA polymerase III subunits gamma and tau YP_002401599.1 519403 D 585055 CDS YP_002401600.1 218693933 7145942 521387..521716 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15322138, 1698765, 2674903; hypothetical protein 521716 ybaB 7145942 ybaB Escherichia coli 55989 hypothetical protein YP_002401600.1 521387 D 585055 CDS YP_002401601.1 218693934 7148096 521716..522321 1 NC_011748.1 involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 522321 recR 7148096 recR Escherichia coli 55989 recombination protein RecR YP_002401601.1 521716 D 585055 CDS YP_002401602.1 218693935 7147367 522431..524305 1 NC_011748.1 molecular chaperone; heat shock protein 90 524305 htpG 7147367 htpG Escherichia coli 55989 heat shock protein 90 YP_002401602.1 522431 D 585055 CDS YP_002401603.1 218693936 7146473 524486..525130 1 NC_011748.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 525130 adk 7146473 adk Escherichia coli 55989 adenylate kinase YP_002401603.1 524486 D 585055 CDS YP_002401604.1 218693937 7145460 525366..526328 1 NC_011748.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 526328 hemH 7145460 hemH Escherichia coli 55989 ferrochelatase YP_002401604.1 525366 D 585055 CDS YP_002401605.1 218693938 7146414 complement(526325..527284) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401025, 98244813, 2051480, 7721718; Product type e : enzyme; acetyl esterase 527284 aes 7146414 aes Escherichia coli 55989 acetyl esterase YP_002401605.1 526325 R 585055 CDS YP_002401606.1 218693939 7145464 527436..528740 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90155203, 95238302, 2051480; Product type e : enzyme; inosine/guanosine kinase 528740 gsk 7145464 gsk Escherichia coli 55989 inosine/guanosine kinase YP_002401606.1 527436 D 585055 CDS YP_002401607.1 218693940 7146375 complement(528873..530549) 1 NC_011748.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; cation:proton antiport protein 530549 ybaL 7146375 ybaL Escherichia coli 55989 cation:proton antiport protein YP_002401607.1 528873 R 585055 CDS YP_002401608.1 218693941 7148100 complement(530787..532007) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 97074653, 8917080; Product type t : transporter; fosmidomycin efflux system, member of the major facilitator superfamily 532007 fsr 7148100 fsr Escherichia coli 55989 fosmidomycin efflux system, member of the major facilitator superfamily YP_002401608.1 530787 R 585055 CDS YP_002401609.1 218693942 7146208 532225..533877 1 NC_011748.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic 533877 ushA 7146208 ushA Escherichia coli 55989 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic YP_002401609.1 532225 D 585055 CDS YP_002401610.1 218693943 7147574 complement(533914..534393) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 534393 ybaK 7147574 ybaK Escherichia coli 55989 hypothetical protein YP_002401610.1 533914 R 585055 CDS YP_002401611.1 218693944 7147708 complement(534597..535391) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 535391 ybaP 7147708 ybaP Escherichia coli 55989 hypothetical protein YP_002401611.1 534597 R 585055 CDS YP_002401612.1 218693945 7148104 535529..535870 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 535870 ybaQ 7148104 ybaQ Escherichia coli 55989 DNA-binding transcriptional regulator YP_002401612.1 535529 D 585055 CDS YP_002401613.1 218693946 7148105 complement(535984..538488) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12351646, 20105527, 11167016, 11500054, 9868784; Product type t : transporter; copper exporting ATPase 538488 copA 7148105 copA Escherichia coli 55989 copper exporting ATPase YP_002401613.1 535984 R 585055 CDS YP_002401614.1 218693947 7145742 538750..539682 1 NC_011748.1 catalyzes the formation of glutamate from glutamine; glutaminase 539682 ybaS 7145742 ybaS Escherichia coli 55989 glutaminase YP_002401614.1 538750 D 585055 CDS YP_002401615.1 218693948 7148106 539685..540977 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; nitrogen-containing metabolite transporter 540977 ybaT 7148106 ybaT Escherichia coli 55989 nitrogen-containing metabolite transporter YP_002401615.1 539685 D 585055 CDS YP_002401616.1 218693949 7148107 541102..541509 1 NC_011748.1 activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 541509 cueR 7148107 cueR Escherichia coli 55989 DNA-binding transcriptional regulator CueR YP_002401616.1 541102 D 585055 CDS YP_002401617.1 218693950 7145789 complement(541510..541965) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 541965 ybbJ 7145789 ybbJ Escherichia coli 55989 inner membrane protein YP_002401617.1 541510 R 585055 CDS YP_002401618.1 218693951 7148115 complement(541965..542882) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; protease, membrane anchored 542882 ybbK 7148115 ybbK Escherichia coli 55989 protease, membrane anchored YP_002401618.1 541965 R 585055 CDS YP_002401619.1 218693952 7148116 543028..543705 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; ABC transporter ATP-binding protein 543705 ybbL 7148116 ybbL Escherichia coli 55989 ABC transporter ATP-binding protein YP_002401619.1 543028 D 585055 CDS YP_002401620.1 218693953 7148117 543692..544471 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; permease of an ABC transporter 544471 ybbM 7148117 ybbM Escherichia coli 55989 permease of an ABC transporter YP_002401620.1 543692 D 585055 CDS YP_002401621.1 218693954 7148118 complement(544534..545388) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; thioredoxin domain-containing protein 545388 ybbN 7148118 ybbN Escherichia coli 55989 thioredoxin domain-containing protein YP_002401621.1 544534 R 585055 CDS YP_002401622.1 218693955 7148119 complement(545449..546258) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; short chain dehydrogenase 546258 ybbO 7148119 ybbO Escherichia coli 55989 short chain dehydrogenase YP_002401622.1 545449 R 585055 CDS YP_002401623.1 218693956 7148120 complement(546248..546874) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91270121, 91324311, 93163029, 93252782, 94179121, 99353977, 1864840, 8432696, 8098033; Product type e : enzyme; multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 546874 tesA 7148120 tesA Escherichia coli 55989 multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 YP_002401623.1 546248 R 585055 CDS YP_002401624.1 218693957 7147775 546842..547528 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; ABC transporter ATP-binding protein 547528 ybbA 7147775 ybbA Escherichia coli 55989 ABC transporter ATP-binding protein YP_002401624.1 546842 D 585055 CDS YP_002401625.1 218693958 7148112 547525..549939 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type t : transporter; ABC transporter permease 549939 ybbP 7148112 ybbP Escherichia coli 55989 ABC transporter permease YP_002401625.1 547525 D 585055 CDS YP_002401626.1 218693959 7148121 550369..554637 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 1766878, 2403547, 2644231, 7934896; Product type h : extrachromosomal origin; rhsD element protein 554637 rhsD 7148121 rhsD Escherichia coli 55989 rhsD element protein YP_002401626.1 550369 D 585055 CDS YP_002401627.1 218693960 7147403 554671..554946 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 554946 insA 7147403 insA Escherichia coli 55989 IS1 repressor protein InsA YP_002401627.1 554671 D 585055 CDS YP_002401628.1 218693961 7146569 554865..555368 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 555368 insB 7146569 insB Escherichia coli 55989 IS1 transposase InsAB' YP_002401628.1 554865 D 585055 CDS YP_002401629.1 218693962 7146581 555475..555843 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 555843 ybbC 7146581 ybbC Escherichia coli 55989 hypothetical protein YP_002401629.1 555475 D 585055 CDS YP_002401630.1 218693963 7148114 555843..556553 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1766878, 7934896; Product type h : extrachromosomal origin; rhs-like 556553 ylbH 7148114 ylbH Escherichia coli 55989 rhs-like YP_002401630.1 555843 D 585055 CDS YP_002401631.1 218693964 7149251 556534..557025 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 557025 7149251 EC55989_0515 Escherichia coli 55989 hypothetical protein YP_002401631.1 556534 D 585055 CDS YP_002401632.1 218693965 7144427 complement(557310..557525) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 557525 7144427 EC55989_0516 Escherichia coli 55989 hypothetical protein YP_002401632.1 557310 R 585055 CDS YP_002401633.1 218693966 7144428 complement(557512..557946) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; regulator with homeodomain-like DNA binding domain 557946 7144428 EC55989_0517 Escherichia coli 55989 regulator with homeodomain-like DNA binding domain YP_002401633.1 557512 R 585055 CDS YP_002401634.1 218693967 7144429 complement(558026..559120) 1 NC_011748.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase 559120 ybbB 7144429 ybbB Escherichia coli 55989 tRNA 2-selenouridine synthase YP_002401634.1 558026 R 585055 CDS YP_002401635.1 218693968 7148113 complement(559189..560115) 1 NC_011748.1 activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS 560115 ybbS 7148113 ybbS Escherichia coli 55989 DNA-binding transcriptional activator AllS YP_002401635.1 559189 R 585055 CDS YP_002401636.1 218693969 7148122 560345..560827 1 NC_011748.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 560827 allA 7148122 allA Escherichia coli 55989 ureidoglycolate hydrolase YP_002401636.1 560345 D 585055 CDS YP_002401637.1 218693970 7145483 560905..561720 1 NC_011748.1 regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 561720 allR 7145483 allR Escherichia coli 55989 DNA-binding transcriptional repressor AllR YP_002401637.1 560905 D 585055 CDS YP_002401638.1 218693971 7145487 561810..563591 1 NC_011748.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 563591 gcl 7145487 gcl Escherichia coli 55989 glyoxylate carboligase YP_002401638.1 561810 D 585055 CDS YP_002401639.1 218693972 7146272 563604..564380 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20029625, 8440684; Product type e : enzyme; hydroxypyruvate isomerase 564380 hyi 7146272 hyi Escherichia coli 55989 hydroxypyruvate isomerase YP_002401639.1 563604 D 585055 CDS YP_002401640.1 218693973 7146519 564480..565358 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme; tartronate semialdehyde reductase, NADH-dependent 565358 glxR 7146519 glxR Escherichia coli 55989 tartronate semialdehyde reductase, NADH-dependent YP_002401640.1 564480 D 585055 CDS YP_002401641.1 218693974 7146338 565527..566981 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1293888; Product type t : transporter; allantoin permease 566981 ybbW 7146338 ybbW Escherichia coli 55989 allantoin permease YP_002401641.1 565527 D 585055 CDS YP_002401642.1 218693975 7148123 567041..568402 1 NC_011748.1 Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 568402 allB 7148123 allB Escherichia coli 55989 allantoinase YP_002401642.1 567041 D 585055 CDS YP_002401643.1 218693976 7145484 568459..569760 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; purine permease YbbY 569760 ybbY 7145484 ybbY Escherichia coli 55989 purine permease YbbY YP_002401643.1 568459 D 585055 CDS YP_002401644.1 218693977 7148124 569782..570927 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme; glycerate kinase 570927 glxK 7148124 glxK Escherichia coli 55989 glycerate kinase YP_002401644.1 569782 D 585055 CDS YP_002401645.1 218693978 7146337 complement(571056..571841) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 571841 ylbA 7146337 ylbA Escherichia coli 55989 hypothetical protein YP_002401645.1 571056 R 585055 CDS YP_002401646.1 218693979 7149248 complement(571852..573087) 1 NC_011748.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase 573087 allC 7149248 allC Escherichia coli 55989 allantoate amidohydrolase YP_002401646.1 571852 R 585055 CDS YP_002401647.1 218693980 7145485 complement(573109..574158) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12460564, 20069628, 69151449; Product type e : enzyme; ureidoglycolate dehydrogenase 574158 allD 7145485 allD Escherichia coli 55989 ureidoglycolate dehydrogenase YP_002401647.1 573109 R 585055 CDS YP_002401648.1 218693981 7145486 574475..576142 1 NC_011748.1 multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 576142 fdrA 7145486 fdrA Escherichia coli 55989 membrane protein FdrA YP_002401648.1 574475 D 585055 CDS YP_002401649.1 218693982 7146075 576152..577411 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 577411 ylbE 7146075 ylbE Escherichia coli 55989 hypothetical protein YP_002401649.1 576152 D 585055 CDS YP_002401650.1 218693983 7149249 577422..578237 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 578237 ylbF 7149249 ylbF Escherichia coli 55989 hypothetical protein YP_002401650.1 577422 D 585055 CDS YP_002401651.1 218693984 7149250 578234..579127 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2464576, 2644189, 7920643, 7940673, 7984428; Product type pe : enzyme; carbamate kinase 579127 ybcF 7149250 ybcF Escherichia coli 55989 carbamate kinase YP_002401651.1 578234 D 585055 CDS YP_002401652.1 218693985 7148125 complement(579322..580389) 1 NC_011748.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit 580389 purK 7148125 purK Escherichia coli 55989 phosphoribosylaminoimidazole carboxylase ATPase subunit YP_002401652.1 579322 R 585055 CDS YP_002401653.1 218693986 7147299 complement(580386..580895) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10074353, 8117684, 89123018, 89123019, 92287929, 10574791; Product type e : enzyme; N5-carboxyaminoimidazole ribonucleotide mutase 580895 purE 7147299 purE Escherichia coli 55989 N5-carboxyaminoimidazole ribonucleotide mutase YP_002401653.1 580386 R 585055 CDS YP_002401654.1 218693987 7147296 complement(581013..581735) 1 NC_011748.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase 581735 lpxH 7147296 lpxH Escherichia coli 55989 UDP-2,3-diacylglucosamine hydrolase YP_002401654.1 581013 R 585055 CDS YP_002401655.1 218693988 7146739 complement(581738..582232) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 1864365, 8601841, 9298646, 9600841; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase B 582232 ppiB 7146739 ppiB Escherichia coli 55989 peptidyl-prolyl cis-trans isomerase B YP_002401655.1 581738 R 585055 CDS YP_002401656.1 218693989 7147229 582406..583791 1 NC_011748.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 583791 cysS 7147229 cysS Escherichia coli 55989 cysteinyl-tRNA synthetase YP_002401656.1 582406 D 585055 CDS YP_002401657.1 218693990 7145834 complement(583827..584348) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 584348 ybcI 7145834 ybcI Escherichia coli 55989 inner membrane protein YP_002401657.1 583827 R 585055 CDS YP_002401658.1 218693991 7148127 complement(584456..584668) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12837795, 1748668, 7567469; Product type pr : regulator; hypothetical protein 584668 ybcJ 7148127 ybcJ Escherichia coli 55989 hypothetical protein YP_002401658.1 584456 R 585055 CDS YP_002401659.1 218693992 7148128 complement(584670..585536) 1 NC_011748.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase 585536 folD 7148128 folD Escherichia coli 55989 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase YP_002401659.1 584670 R 585055 CDS YP_002401660.1 218693993 7146171 586017..586559 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2890624; Product type ps : structure; fimbrial-like adhesin protein 586559 sfmA 7146171 sfmA Escherichia coli 55989 fimbrial-like adhesin protein YP_002401660.1 586017 D 585055 CDS YP_002401661.1 218693994 7147640 586779..587471 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15372038, 2553674; Product type f : factor; pilin chaperone, periplasmic 587471 sfmC 7147640 sfmC Escherichia coli 55989 pilin chaperone, periplasmic YP_002401661.1 586779 D 585055 CDS YP_002401662.1 218693995 7147641 587502..590111 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1970114; Product type pf : factor; outer membrane export usher protein 590111 sfmD 7147641 sfmD Escherichia coli 55989 outer membrane export usher protein YP_002401662.1 587502 D 585055 CDS YP_002401663.1 218693996 7147642 590154..591131 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 591131 sfmH 7147642 sfmH Escherichia coli 55989 fimbrial-like adhesin protein YP_002401663.1 590154 D 585055 CDS YP_002401664.1 218693997 7147644 591142..591657 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2890624; Product type ps : structure; fimbrial protein 591657 sfmF 7147644 sfmF Escherichia coli 55989 fimbrial protein YP_002401664.1 591142 D 585055 CDS YP_002401665.1 218693998 7147643 complement(591660..592292) 1 NC_011748.1 activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ 592292 fimZ 7147643 fimZ Escherichia coli 55989 transcriptional regulator FimZ YP_002401665.1 591660 R 585055 CDS YP_002401666.1 218693999 7145383 complement(592541..592663) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 592663 7145383 EC55989_0550 Escherichia coli 55989 hypothetical protein YP_002401666.1 592541 R 585055 CDS YP_002401667.1 218694000 7144430 complement(592657..593418) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6317653, 2536924; Product type r : regulator; DNA-binding transcriptional activator of porin biosynthesis 593418 envY 7144430 envY Escherichia coli 55989 DNA-binding transcriptional activator of porin biosynthesis YP_002401667.1 592657 R 585055 CDS YP_002401668.1 218694001 7146007 complement(593601..594491) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 594491 ybcH 7146007 ybcH Escherichia coli 55989 hypothetical protein YP_002401668.1 593601 R 585055 CDS YP_002401669.1 218694002 7148126 complement(594492..597464) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89359086, 94042873, 94042874; Product type m : membrane component; bacteriophage N4 receptor, outer membrane subunit 597464 nfrA 7148126 nfrA Escherichia coli 55989 bacteriophage N4 receptor, outer membrane subunit YP_002401669.1 594492 R 585055 CDS YP_002401670.1 218694003 7146988 complement(597451..599688) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89359086, 94042873, 94042874; Product type m : membrane component; bacteriophage N4 adsorption protein B 599688 nfrB 7146988 nfrB Escherichia coli 55989 bacteriophage N4 adsorption protein B YP_002401670.1 597451 R 585055 CDS YP_002401671.1 218694004 7146989 complement(599957..601093) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype; transposase 601093 yhhI 7146989 yhhI Escherichia coli 55989 transposase YP_002401671.1 599957 R 585055 CDS YP_002401672.1 218694005 7148980 complement(601197..601508) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 601508 7148980 EC55989_0556 Escherichia coli 55989 hypothetical protein YP_002401672.1 601197 R 585055 CDS YP_002401673.1 218694006 7144431 complement(601623..601874) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 601874 7144431 EC55989_0557 Escherichia coli 55989 hypothetical protein YP_002401673.1 601623 R 585055 CDS YP_002401674.1 218694007 7144432 complement(601871..606733) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1766878, 2644231, 2403547, 7934896; Rhs core protein with extension 606733 7144432 EC55989_0558 Escherichia coli 55989 Rhs core protein with extension YP_002401674.1 601871 R 585055 CDS YP_002401675.1 218694008 7144433 complement(606753..607214) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 607214 7144433 EC55989_0559 Escherichia coli 55989 hypothetical protein YP_002401675.1 606753 R 585055 CDS YP_002401676.1 218694009 7144434 complement(607242..609143) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9696756, 8557353; Rhs element Vgr protein 609143 7144434 EC55989_0560 Escherichia coli 55989 Rhs element Vgr protein YP_002401676.1 607242 R 585055 CDS YP_002401677.1 218694010 7144435 complement(609880..611340) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 11283292, 11399769; Product type r : regulator; sensor kinase CusS 611340 cusS 7144435 cusS Escherichia coli 55989 sensor kinase CusS YP_002401677.1 609880 R 585055 CDS YP_002401678.1 218694011 7145797 complement(611318..612001) 1 NC_011748.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR 612001 cusR 7145797 cusR Escherichia coli 55989 DNA-binding transcriptional activator CusR YP_002401678.1 611318 R 585055 CDS YP_002401679.1 218694012 7145795 612158..613540 1 NC_011748.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 613540 cusC 7145795 cusC Escherichia coli 55989 copper/silver efflux system outer membrane protein CusC YP_002401679.1 612158 D 585055 CDS YP_002401680.1 218694013 7145793 613564..613896 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 21125583, 11283292, 11399769, 12813074; Product type f : factor; copper-binding protein 613896 cusF 7145793 cusF Escherichia coli 55989 copper-binding protein YP_002401680.1 613564 D 585055 CDS YP_002401681.1 218694014 7145794 613912..615135 1 NC_011748.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 615135 cusB 7145794 cusB Escherichia coli 55989 copper/silver efflux system membrane fusion protein CusB YP_002401681.1 613912 D 585055 CDS YP_002401682.1 218694015 7145792 615147..618290 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 21125583, 21178899, 21450803, 11399769, 12813074, 1711024, 7984428; Product type t : transporter; copper/silver efflux system, membrane component 618290 cusA 7145792 cusA Escherichia coli 55989 copper/silver efflux system, membrane component YP_002401682.1 615147 D 585055 CDS YP_002401683.1 218694016 7145790 618392..619768 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91267923, 94042931, 8626334; Product type t : transporter; phenylalanine transporter 619768 pheP 7145790 pheP Escherichia coli 55989 phenylalanine transporter YP_002401683.1 618392 D 585055 CDS YP_002401684.1 218694017 7147160 complement(619836..621083) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; membrane protein; channel 621083 ybdG 7147160 ybdG Escherichia coli 55989 membrane protein; channel YP_002401684.1 619836 R 585055 CDS YP_002401685.1 218694018 7148142 complement(621191..621844) 1 NC_011748.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase 621844 nfnB 7148142 nfnB Escherichia coli 55989 dihydropteridine reductase YP_002401685.1 621191 R 585055 CDS YP_002401686.1 218694019 7146986 complement(621938..622306) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 622306 ybdF 7146986 ybdF Escherichia coli 55989 hypothetical protein YP_002401686.1 621938 R 585055 CDS YP_002401687.1 218694020 7148141 complement(622371..622619) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 622619 ybdJ 7148141 ybdJ Escherichia coli 55989 inner membrane protein YP_002401687.1 622371 R 585055 CDS YP_002401688.1 218694021 7148144 complement(622685..623803) 1 NC_011748.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase 623803 ybdK 7148144 ybdK Escherichia coli 55989 carboxylate-amine ligase YP_002401688.1 622685 R 585055 CDS YP_002401689.1 218694022 7148145 624245..624397 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99291074; Product type f : factor; toxic polypeptide, small 624397 hokE 7148145 hokE Escherichia coli 55989 toxic polypeptide, small YP_002401689.1 624245 D 585055 CDS YP_002401690.1 218694023 7146452 complement(625022..625651) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89313305, 90132534, 91035252, 8939709, 9214294; Product type e : enzyme; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex 625651 entD 7146452 entD Escherichia coli 55989 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex YP_002401690.1 625022 R 585055 CDS YP_002401691.1 218694024 7146002 complement(625817..628057) 1 NC_011748.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA 628057 fepA 7146002 fepA Escherichia coli 55989 outer membrane receptor FepA YP_002401691.1 625817 R 585055 CDS YP_002401692.1 218694025 7146088 628378..629502 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92291125, 94198561, 2974033; Product type e : enzyme; enterobactin/ferric enterobactin esterase 629502 fes 7146088 fes Escherichia coli 55989 enterobactin/ferric enterobactin esterase YP_002401692.1 628378 D 585055 CDS YP_002401693.1 218694026 7146094 629505..629723 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 629723 ybdZ 7146094 ybdZ Escherichia coli 55989 hypothetical protein YP_002401693.1 629505 D 585055 CDS YP_002401694.1 218694027 7148149 629720..633601 1 NC_011748.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 633601 entF 7148149 entF Escherichia coli 55989 enterobactin synthase subunit F YP_002401694.1 629720 D 585055 CDS YP_002401695.1 218694028 7146004 633817..634950 1 NC_011748.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 634950 fepE 7146004 fepE Escherichia coli 55989 ferric enterobactin transport protein FepE YP_002401695.1 633817 D 585055 CDS YP_002401696.1 218694029 7146092 complement(634947..635762) 1 NC_011748.1 with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein 635762 fepC 7146092 fepC Escherichia coli 55989 iron-enterobactin transporter ATP-binding protein YP_002401696.1 634947 R 585055 CDS YP_002401697.1 218694030 7146090 complement(635759..636751) 1 NC_011748.1 with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease 636751 fepG 7146090 fepG Escherichia coli 55989 iron-enterobactin transporter permease YP_002401697.1 635759 R 585055 CDS YP_002401698.1 218694031 7146093 complement(636748..637752) 1 NC_011748.1 with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein 637752 fepD 7146093 fepD Escherichia coli 55989 iron-enterobactin transporter membrane protein YP_002401698.1 636748 R 585055 CDS YP_002401699.1 218694032 7146091 637863..639113 1 NC_011748.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 639113 ybdA 7146091 ybdA Escherichia coli 55989 enterobactin exporter EntS YP_002401699.1 637863 D 585055 CDS YP_002401700.1 218694033 7148138 complement(639117..640073) 1 NC_011748.1 with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein 640073 fepB 7148138 fepB Escherichia coli 55989 iron-enterobactin transporter periplasmic binding protein YP_002401700.1 639117 R 585055 CDS YP_002401701.1 218694034 7146089 640448..641623 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123153, 90165423, 90241936, 2110093, 2139473; Product type e : enzyme; isochorismate synthase 1 641623 entC 7146089 entC Escherichia coli 55989 isochorismate synthase 1 YP_002401701.1 640448 D 585055 CDS YP_002401702.1 218694035 7146001 641633..643243 1 NC_011748.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 643243 entE 7146001 entE Escherichia coli 55989 enterobactin synthase subunit E YP_002401702.1 641633 D 585055 CDS YP_002401703.1 218694036 7146003 643257..644114 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20183918, 90241937, 91035252, 9485415, 97361959, 2521621, 2521622; Product type e : enzyme; isochorismatase 644114 entB 7146003 entB Escherichia coli 55989 isochorismatase YP_002401703.1 643257 D 585055 CDS YP_002401704.1 218694037 7146000 644114..644860 1 NC_011748.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 644860 entA 7146000 entA Escherichia coli 55989 2,3-dihydroxybenzoate-2,3-dehydrogenase YP_002401704.1 644114 D 585055 CDS YP_002401705.1 218694038 7145999 644863..645276 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2521621, 2521622, 15808744; Product type pe : enzyme; hypothetical protein 645276 ybdB 7145999 ybdB Escherichia coli 55989 hypothetical protein YP_002401705.1 644863 D 585055 CDS YP_002401706.1 218694039 7148139 645457..647562 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91162636, 2521622; Product type pf : factor; carbon starvation protein 647562 cstA 7148139 cstA Escherichia coli 55989 carbon starvation protein YP_002401706.1 645457 D 585055 CDS YP_002401707.1 218694040 7145787 647744..647941 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 647941 ybdD 7145787 ybdD Escherichia coli 55989 hypothetical protein YP_002401707.1 647744 D 585055 CDS YP_002401708.1 218694041 7148140 complement(647951..649039) 1 NC_011748.1 member of the iron-containing alcohol dehydrogenase family; unknown function; hypothetical protein 649039 ybdH 7148140 ybdH Escherichia coli 55989 hypothetical protein YP_002401708.1 647951 R 585055 CDS YP_002401709.1 218694042 7148143 649148..650308 1 NC_011748.1 catalyzes the transfer of an amino moiety; aminotransferase 650308 ybdL 7148143 ybdL Escherichia coli 55989 aminotransferase YP_002401709.1 649148 D 585055 CDS YP_002401710.1 218694043 7148146 complement(650309..650938) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator 650938 ibrB 7148146 ibrB Escherichia coli 55989 immunoglobulin-binding regulator YP_002401710.1 650309 R 585055 CDS YP_002401711.1 218694044 7146535 complement(650911..652131) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator 652131 ibrA 7146535 ibrA Escherichia coli 55989 immunoglobulin-binding regulator YP_002401711.1 650911 R 585055 CDS YP_002401712.1 218694045 7146533 complement(652278..653180) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator, LysR-type 653180 ybdO 7146533 ybdO Escherichia coli 55989 DNA-binding transcriptional regulator, LysR-type YP_002401712.1 652278 R 585055 CDS YP_002401713.1 218694046 7148147 complement(653389..654135) 1 NC_011748.1 Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase 654135 dsbG 7148147 dsbG Escherichia coli 55989 disulfide isomerase/thiol-disulfide oxidase YP_002401713.1 653389 R 585055 CDS YP_002401714.1 218694047 7145953 654507..655070 1 NC_011748.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase 655070 ahpC 7145953 ahpC Escherichia coli 55989 alkyl hydroperoxide reductase YP_002401714.1 654507 D 585055 CDS YP_002401715.1 218694048 7145474 655199..656764 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89197774, 1592833; Product type e : enzyme; alkyl hydroperoxide reductase 656764 ahpF 7145474 ahpF Escherichia coli 55989 alkyl hydroperoxide reductase YP_002401715.1 655199 D 585055 CDS YP_002401716.1 218694049 7145475 complement(656885..657313) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12071968; Product type f : factor; universal stress protein UP12 657313 uspG 7145475 uspG Escherichia coli 55989 universal stress protein UP12 YP_002401716.1 656885 R 585055 CDS YP_002401717.1 218694050 7147931 657534..658772 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8185833; Product type pe : enzyme; oxidoreductase, Zn-dependent and NAD(P)-binding 658772 ybdR 7147931 ybdR Escherichia coli 55989 oxidoreductase, Zn-dependent and NAD(P)-binding YP_002401717.1 657534 D 585055 CDS YP_002401718.1 218694051 7148148 complement(659003..659413) 1 NC_011748.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator 659413 rnk 7148148 rnk Escherichia coli 55989 nucleoside diphosphate kinase regulator YP_002401718.1 659003 R 585055 CDS YP_002401719.1 218694052 7147452 complement(659643..660449) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90151658, 90264307, 2253883, 8188249; Product type e : enzyme; ribonuclease I 660449 rna 7147452 rna Escherichia coli 55989 ribonuclease I YP_002401719.1 659643 R 585055 CDS YP_002401720.1 218694053 7147432 complement(660563..662026) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9696764; Product type t : transporter; citrate:succinate antiporter 662026 citT 7147432 citT Escherichia coli 55989 citrate:succinate antiporter YP_002401720.1 660563 R 585055 CDS YP_002401721.1 218694054 7145716 complement(662077..662955) 1 NC_011748.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase 662955 citG 7145716 citG Escherichia coli 55989 triphosphoribosyl-dephospho-CoA synthase YP_002401721.1 662077 R 585055 CDS YP_002401722.1 218694055 7145715 complement(662930..663481) 1 NC_011748.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase 663481 citX 7145715 citX Escherichia coli 55989 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase YP_002401722.1 662930 R 585055 CDS YP_002401723.1 218694056 7145717 complement(663485..665017) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citrate-ACP transferase (alpha) subunit 665017 citF 7145717 citF Escherichia coli 55989 citrate lyase, citrate-ACP transferase (alpha) subunit YP_002401723.1 663485 R 585055 CDS YP_002401724.1 218694057 7145714 complement(665028..665936) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citryl-ACP lyase (beta) subunit 665936 citE 7145714 citE Escherichia coli 55989 citrate lyase, citryl-ACP lyase (beta) subunit YP_002401724.1 665028 R 585055 CDS YP_002401725.1 218694058 7145713 complement(665933..666229) 1 NC_011748.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma 666229 citD 7145713 citD Escherichia coli 55989 citrate lyase subunit gamma YP_002401725.1 665933 R 585055 CDS YP_002401726.1 218694059 7145712 complement(666244..667302) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase synthetase 667302 citC 7145712 citC Escherichia coli 55989 citrate lyase synthetase YP_002401726.1 666244 R 585055 CDS YP_002401727.1 218694060 7145711 667682..669340 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11889485, 21885746, 9701802; Product type r : regulator; sensory histidine kinase in two-component regulatory system with citB 669340 citA 7145711 citA Escherichia coli 55989 sensory histidine kinase in two-component regulatory system with citB YP_002401727.1 667682 D 585055 CDS YP_002401728.1 218694061 7145709 669309..669989 1 NC_011748.1 regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 669989 dpiA 7145709 dpiA Escherichia coli 55989 two-component response regulator DpiA YP_002401728.1 669309 D 585055 CDS YP_002401729.1 218694062 7145710 complement(670030..671415) 1 NC_011748.1 responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC 671415 dcuC 7145710 dcuC Escherichia coli 55989 C4-dicarboxylate transporter DcuC YP_002401729.1 670030 R 585055 CDS YP_002401730.1 218694063 7145862 672004..672564 1 NC_011748.1 catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 672564 pagP 7145862 pagP Escherichia coli 55989 palmitoyl transferase YP_002401730.1 672004 D 585055 CDS YP_002401731.1 218694064 7145751 672739..672948 1 NC_011748.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 672948 cspE 7145751 cspE Escherichia coli 55989 cold shock protein CspE YP_002401731.1 672739 D 585055 CDS YP_002401732.1 218694065 7145780 complement(673002..673385) 1 NC_011748.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB 673385 crcB 7145780 crcB Escherichia coli 55989 camphor resistance protein CrcB YP_002401732.1 673002 R 585055 CDS YP_002401733.1 218694066 7145752 673703..674266 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; amidase 674266 ybeM 7145752 ybeM Escherichia coli 55989 amidase YP_002401733.1 673703 D 585055 CDS YP_002401734.1 218694067 7148155 674395..674598 1 NC_011748.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein E 674598 tatE 7148155 tatE Escherichia coli 55989 twin arginine translocase protein E YP_002401734.1 674395 D 585055 CDS YP_002401735.1 218694068 7147757 complement(674699..675664) 1 NC_011748.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase 675664 lipA 7147757 lipA Escherichia coli 55989 lipoyl synthase YP_002401735.1 674699 R 585055 CDS YP_002401736.1 218694069 7146703 complement(675873..676826) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12218038; Product type pr : regulator; DNA-binding transcriptional regulator 676826 ybeF 7146703 ybeF Escherichia coli 55989 DNA-binding transcriptional regulator YP_002401736.1 675873 R 585055 CDS YP_002401737.1 218694070 7148153 complement(677085..677726) 1 NC_011748.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B 677726 lipB 7148153 lipB Escherichia coli 55989 lipoate-protein ligase B YP_002401737.1 677085 R 585055 CDS YP_002401738.1 218694071 7146704 complement(677827..678090) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8444795; hypothetical protein 678090 ybeD 7146704 ybeD Escherichia coli 55989 hypothetical protein YP_002401738.1 677827 R 585055 CDS YP_002401739.1 218694072 7148152 complement(678201..679412) 1 NC_011748.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase 679412 dacA 7148152 dacA Escherichia coli 55989 D-alanyl-D-alanine carboxypeptidase YP_002401739.1 678201 R 585055 CDS YP_002401740.1 218694073 7145841 complement(679551..680639) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88058785, 2644207; Product type lp : lipoprotein; rare lipoprotein A 680639 rlpA 7145841 rlpA Escherichia coli 55989 rare lipoprotein A YP_002401740.1 679551 R 585055 CDS YP_002401741.1 218694074 7147424 complement(680650..681762) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123070, 90036736, 91072213, 3316191; Product type cp : cell process; cell wall shape-determining protein 681762 mrdB 7147424 mrdB Escherichia coli 55989 cell wall shape-determining protein YP_002401741.1 680650 R 585055 CDS YP_002401742.1 218694075 7146901 complement(681765..683666) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86196149, 87030266, 89174517, 2644207; Product type e : enzyme; penicillin-binding protein 2 683666 mrdA 7146901 mrdA Escherichia coli 55989 penicillin-binding protein 2 YP_002401742.1 681765 R 585055 CDS YP_002401743.1 218694076 7146900 complement(683697..684164) 1 NC_011748.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase 684164 ybeA 7146900 ybeA Escherichia coli 55989 rRNA large subunit methyltransferase YP_002401743.1 683697 R 585055 CDS YP_002401744.1 218694077 7148150 complement(684168..684485) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 684485 ybeB 7148150 ybeB Escherichia coli 55989 hypothetical protein YP_002401744.1 684168 R 585055 CDS YP_002401745.1 218694078 7148151 complement(684746..685357) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7929373; Product type pe : enzyme; phosphatase with phosphoglycerate mutase domain 685357 phpB 7148151 phpB Escherichia coli 55989 phosphatase with phosphoglycerate mutase domain YP_002401745.1 684746 R 585055 CDS YP_002401746.1 218694079 7147188 complement(685381..686022) 1 NC_011748.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase 686022 nadD 7147188 nadD Escherichia coli 55989 nicotinic acid mononucleotide adenylyltransferase YP_002401746.1 685381 R 585055 CDS YP_002401747.1 218694080 7146945 complement(686024..687055) 1 NC_011748.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta 687055 holA 7146945 holA Escherichia coli 55989 DNA polymerase III subunit delta YP_002401747.1 686024 R 585055 CDS YP_002401748.1 218694081 7146453 complement(687055..687636) 1 NC_011748.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB 687636 rlpB 7146453 rlpB Escherichia coli 55989 LPS-assembly lipoprotein RlpB YP_002401748.1 687055 R 585055 CDS YP_002401749.1 218694082 7147425 complement(687651..690233) 1 NC_011748.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase 690233 leuS 7147425 leuS Escherichia coli 55989 leucyl-tRNA synthetase YP_002401749.1 687651 R 585055 CDS YP_002401750.1 218694083 7146695 690468..690950 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11373298, 12105207, 3320963, 7567469; hypothetical protein 690950 ybeL 7146695 ybeL Escherichia coli 55989 hypothetical protein YP_002401750.1 690468 D 585055 CDS YP_002401751.1 218694084 7148154 complement(691020..691997) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 691997 ybeQ 7148154 ybeQ Escherichia coli 55989 hypothetical protein YP_002401751.1 691020 R 585055 CDS YP_002401752.1 218694085 7148156 692161..692868 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 692868 ybeR 7148156 ybeR Escherichia coli 55989 hypothetical protein YP_002401752.1 692161 D 585055 CDS YP_002401753.1 218694086 7148157 692865..694292 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12183460, 10574456; Product type pf : factor; DnaJ-class chaperone 694292 djlB 7148157 djlB Escherichia coli 55989 DnaJ-class chaperone YP_002401753.1 692865 D 585055 CDS YP_002401754.1 218694087 7145922 complement(694302..694856) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; outer membrane protein 694856 ybeT 7145922 ybeT Escherichia coli 55989 outer membrane protein YP_002401754.1 694302 R 585055 CDS YP_002401755.1 218694088 7148158 694957..695664 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 695664 ybeU 7148158 ybeU Escherichia coli 55989 hypothetical protein YP_002401755.1 694957 D 585055 CDS YP_002401756.1 218694089 7148159 695661..697112 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12183460, 12054669; Product type f : factor; Hsc56 co-chaperone of HscC 697112 djlC 7148159 djlC Escherichia coli 55989 Hsc56 co-chaperone of HscC YP_002401756.1 695661 D 585055 CDS YP_002401757.1 218694090 7147440 698876..700084 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L 700084 7147440 EC55989_0643 Escherichia coli 55989 transposase, IS4 family, IS10L YP_002401757.1 698876 D 585055 CDS YP_002401758.1 218694091 7146464 complement(700264..701199) 1 NC_011748.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 701199 rihA 7146464 rihA Escherichia coli 55989 ribonucleoside hydrolase 1 YP_002401758.1 700264 R 585055 CDS YP_002401759.1 218694092 7147415 complement(701317..702042) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate transporter subunit ; ATP-binding component of ABC superfamily 702042 gltL 7147415 gltL Escherichia coli 55989 glutamate and aspartate transporter subunit ; ATP-binding component of ABC superfamily YP_002401759.1 701317 R 585055 CDS YP_002401760.1 218694093 7146333 complement(702042..702716) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate transporter subunit ; membrane component of ABC superfamily 702716 gltK 7146333 gltK Escherichia coli 55989 glutamate and aspartate transporter subunit ; membrane component of ABC superfamily YP_002401760.1 702042 R 585055 CDS YP_002401761.1 218694094 7146332 complement(702716..703456) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate transporter subunit ; membrane component of ABC superfamily 703456 gltJ 7146332 gltJ Escherichia coli 55989 glutamate and aspartate transporter subunit ; membrane component of ABC superfamily YP_002401761.1 702716 R 585055 CDS YP_002401762.1 218694095 7145301 complement(703626..704534) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1091636, 1091635, 10493123, 8740179, 10972807; Product type t : transporter; glutamate and aspartate transporter subunit 704534 gltI 7145301 gltI Escherichia coli 55989 glutamate and aspartate transporter subunit YP_002401762.1 703626 R 585055 CDS YP_002401763.1 218694096 7144438 complement(706943..708481) 1 NC_011748.1 Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase 708481 lnt 7144438 lnt Escherichia coli 55989 apolipoprotein N-acyltransferase YP_002401763.1 706943 R 585055 CDS YP_002401764.1 218694097 7146714 complement(708506..709384) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1779764; Product type pt : transporter; protein involved in divalent ion export 709384 ybeX 7146714 ybeX Escherichia coli 55989 protein involved in divalent ion export YP_002401764.1 708506 R 585055 CDS YP_002401765.1 218694098 7148160 complement(709474..709941) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16511207; Product type pe : enzyme; metalloprotease 709941 ybeY 7148160 ybeY Escherichia coli 55989 metalloprotease YP_002401765.1 709474 R 585055 CDS YP_002401766.1 218694099 7148161 complement(709938..711017) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12762842; Product type pe : enzyme; enzyme with nucleoside triphosphate hydrolase domain 711017 ybeZ 7148161 ybeZ Escherichia coli 55989 enzyme with nucleoside triphosphate hydrolase domain YP_002401766.1 709938 R 585055 CDS YP_002401767.1 218694100 7148162 complement(711131..712555) 1 NC_011748.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase 712555 miaB 7148162 miaB Escherichia coli 55989 (dimethylallyl)adenosine tRNA methylthiotransferase YP_002401767.1 711131 R 585055 CDS YP_002401768.1 218694101 7146853 712701..713876 1 NC_011748.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 713876 ubiF 7146853 ubiF Escherichia coli 55989 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase YP_002401768.1 712701 D 585055 CDS YP_002401769.1 218694102 7145403 complement(715114..716778) 1 NC_011748.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B 716778 asnB 7145403 asnB Escherichia coli 55989 asparagine synthetase B YP_002401769.1 715114 R 585055 CDS YP_002401770.1 218694103 7145568 complement(717035..717787) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16430214, 89343637; Product type e : enzyme; UMP phosphatase 717787 nagD 7145568 nagD Escherichia coli 55989 UMP phosphatase YP_002401770.1 717035 R 585055 CDS YP_002401771.1 218694104 7146951 complement(717835..719055) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15066032, 90136533, 91171292, 92114782, 92356048, 2190615, 2668691, 7545108; Product type r : regulator; DNA-binding transcriptional dual regulator 719055 nagC 7146951 nagC Escherichia coli 55989 DNA-binding transcriptional dual regulator YP_002401771.1 717835 R 585055 CDS YP_002401772.1 218694105 7146950 complement(719064..720212) 1 NC_011748.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase 720212 nagA 7146950 nagA Escherichia coli 55989 N-acetylglucosamine-6-phosphate deacetylase YP_002401772.1 719064 R 585055 CDS YP_002401773.1 218694106 7146948 complement(720272..721072) 1 NC_011748.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase 721072 nagB 7146948 nagB Escherichia coli 55989 glucosamine-6-phosphate deaminase YP_002401773.1 720272 R 585055 CDS YP_002401774.1 218694107 7146949 721405..723351 1 NC_011748.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunit IIABC 723351 nagE 7146949 nagE Escherichia coli 55989 PTS system N-acetyl glucosamine specific transporter subunit IIABC YP_002401774.1 721405 D 585055 CDS YP_002401775.1 218694108 7146952 723554..725218 1 NC_011748.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 725218 glnS 7146952 glnS Escherichia coli 55989 glutaminyl-tRNA synthetase YP_002401775.1 723554 D 585055 CDS YP_002401776.1 218694109 7146312 725664..727070 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2118530, 9636669; Product type pt : transporter; outer membrane porin 727070 ybfM 7146312 ybfM Escherichia coli 55989 outer membrane porin YP_002401776.1 725664 D 585055 CDS YP_002401777.1 218694110 7148168 727120..727446 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; lipoprotein 727446 ybfN 7148168 ybfN Escherichia coli 55989 lipoprotein YP_002401777.1 727120 D 585055 CDS YP_002401778.1 218694111 7148169 complement(727530..727976) 1 NC_011748.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator 727976 fur 7148169 fur Escherichia coli 55989 ferric uptake regulator YP_002401778.1 727530 R 585055 CDS YP_002401779.1 218694112 7146233 728021..728275 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 728275 7146233 EC55989_0670 Escherichia coli 55989 hypothetical protein YP_002401779.1 728021 D 585055 CDS YP_002401780.1 218694113 7144439 complement(728265..728795) 1 NC_011748.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA 728795 fldA 7144439 fldA Escherichia coli 55989 flavodoxin FldA YP_002401780.1 728265 R 585055 CDS YP_002401781.1 218694114 7146122 complement(728935..729228) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20223640, 12427949; Product type cp : cell process; LexA regulated protein 729228 ybfE 7146122 ybfE Escherichia coli 55989 LexA regulated protein YP_002401781.1 728935 R 585055 CDS YP_002401782.1 218694115 7148166 complement(729368..730132) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : enzyme; hypothetical protein 730132 ybfF 7148166 ybfF Escherichia coli 55989 hypothetical protein YP_002401782.1 729368 R 585055 CDS YP_002401783.1 218694116 7148167 730317..730862 1 NC_011748.1 negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 730862 seqA 7148167 seqA Escherichia coli 55989 replication initiation regulator SeqA YP_002401783.1 730317 D 585055 CDS YP_002401784.1 218694117 7147631 730888..732528 1 NC_011748.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 732528 pgm 7147631 pgm Escherichia coli 55989 phosphoglucomutase YP_002401784.1 730888 D 585055 CDS YP_002401785.1 218694118 7147153 complement(732584..733903) 1 NC_011748.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter 733903 potE 7147153 potE Escherichia coli 55989 putrescine transporter YP_002401785.1 732584 R 585055 CDS YP_002401786.1 218694119 7147213 complement(733900..736098) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92041955; Product type e : enzyme; ornithine decarboxylase 736098 speF 7147213 speF Escherichia coli 55989 ornithine decarboxylase YP_002401786.1 733900 R 585055 CDS YP_002401787.1 218694120 7147690 complement(736788..737465) 1 NC_011748.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE 737465 kdpE 7147690 kdpE Escherichia coli 55989 DNA-binding transcriptional activator KdpE YP_002401787.1 736788 R 585055 CDS YP_002401788.1 218694121 7146658 complement(737462..740146) 1 NC_011748.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD 740146 kdpD 7146658 kdpD Escherichia coli 55989 sensor protein KdpD YP_002401788.1 737462 R 585055 CDS YP_002401789.1 218694122 7146657 complement(740139..740711) 1 NC_011748.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C 740711 kdpC 7146657 kdpC Escherichia coli 55989 potassium-transporting ATPase subunit C YP_002401789.1 740139 R 585055 CDS YP_002401790.1 218694123 7146656 complement(740720..742768) 1 NC_011748.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B 742768 kdpB 7146656 kdpB Escherichia coli 55989 potassium-transporting ATPase subunit B YP_002401790.1 740720 R 585055 CDS YP_002401791.1 218694124 7146655 complement(742791..744464) 1 NC_011748.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A 744464 kdpA 7146655 kdpA Escherichia coli 55989 potassium-transporting ATPase subunit A YP_002401791.1 742791 R 585055 CDS YP_002401792.1 218694125 7146654 744866..745072 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 745072 ybfA 7146654 ybfA Escherichia coli 55989 hypothetical protein YP_002401792.1 744866 D 585055 CDS YP_002401793.1 218694126 7148163 745315..749508 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 2403547, 2644231, 7934896, 8387990; Product type h : extrachromosomal origin; rhsC element core protein RshC 749508 rhsC 7148163 rhsC Escherichia coli 55989 rhsC element core protein RshC YP_002401793.1 745315 D 585055 CDS YP_002401794.1 218694127 7147402 749508..749834 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 749834 ybfB 7147402 ybfB Escherichia coli 55989 inner membrane protein YP_002401794.1 749508 D 585055 CDS YP_002401795.1 218694128 7148164 749952..751385 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; rhs-like 751385 ybfO 7148164 ybfO Escherichia coli 55989 rhs-like YP_002401795.1 749952 D 585055 CDS YP_002401796.1 218694129 7148170 751382..751951 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 751951 ybfC 7148170 ybfC Escherichia coli 55989 hypothetical protein YP_002401796.1 751382 D 585055 CDS YP_002401797.1 218694130 7148982 753466..753975 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6325460, 8387990; hypothetical protein 753975 ybgA 7148982 ybgA Escherichia coli 55989 hypothetical protein YP_002401797.1 753466 D 585055 CDS YP_002401798.1 218694131 7148171 753972..755390 1 NC_011748.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 755390 phr 7148171 phr Escherichia coli 55989 deoxyribodipyrimidine photolyase YP_002401798.1 753972 D 585055 CDS YP_002401799.1 218694132 7147189 complement(755432..756913) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15175316; Product type pt : transporter; transporter 756913 ybgH 7147189 ybgH Escherichia coli 55989 transporter YP_002401799.1 755432 R 585055 CDS YP_002401800.1 218694133 7148175 757184..757927 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14519207; hydrolase-oxidase 757927 ybgI 7148175 ybgI Escherichia coli 55989 hydrolase-oxidase YP_002401800.1 757184 D 585055 CDS YP_002401801.1 218694134 7148176 757950..758606 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase subunit 758606 ybgJ 7148176 ybgJ Escherichia coli 55989 hydrolase subunit YP_002401801.1 757950 D 585055 CDS YP_002401802.1 218694135 7148177 758600..759532 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase subunit 759532 ybgK 7148177 ybgK Escherichia coli 55989 hydrolase subunit YP_002401802.1 758600 D 585055 CDS YP_002401803.1 218694136 7148178 759522..760256 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1729609; Product type pe : enzyme; LamB/YcsF family protein 760256 ybgL 7148178 ybgL Escherichia coli 55989 LamB/YcsF family protein YP_002401803.1 759522 D 585055 CDS YP_002401804.1 218694137 7148179 760292..761083 1 NC_011748.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 761083 nei 7148179 nei Escherichia coli 55989 endonuclease VIII YP_002401804.1 760292 D 585055 CDS YP_002401805.1 218694138 7146983 complement(761080..762126) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8002588; Product type ph : phenotype; hypothetical protein 762126 abrB 7146983 abrB Escherichia coli 55989 hypothetical protein YP_002401805.1 761080 R 585055 CDS YP_002401806.1 218694139 7145427 complement(762278..763339) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 763339 ybgO 7145427 ybgO Escherichia coli 55989 hypothetical protein YP_002401806.1 762278 R 585055 CDS YP_002401807.1 218694140 7148180 complement(763336..764091) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10049807; Product type pf : factor; chaperone, PapD family 764091 ybgP 7148180 ybgP Escherichia coli 55989 chaperone, PapD family YP_002401807.1 763336 R 585055 CDS YP_002401808.1 218694141 7148181 complement(764082..766583) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; outer membrane protein 766583 ybgQ 7148181 ybgQ Escherichia coli 55989 outer membrane protein YP_002401808.1 764082 R 585055 CDS YP_002401809.1 218694142 7148182 complement(766592..767158) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; fimbrial-like adhesin protein 767158 7148182 EC55989_0702 Escherichia coli 55989 fimbrial-like adhesin protein YP_002401809.1 766592 R 585055 CDS YP_002401810.1 218694143 7144440 complement(767548..768831) 1 NC_011748.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase 768831 gltA 7144440 gltA Escherichia coli 55989 type II citrate synthase YP_002401810.1 767548 R 585055 CDS YP_002401811.1 218694144 7146327 complement(769037..769195) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 769195 7146327 EC55989_0704 Escherichia coli 55989 hypothetical protein YP_002401811.1 769037 R 585055 CDS YP_002401812.1 218694145 7144441 769540..769929 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6237244, 89076355, 89123360, 9521736, 99414342, 11259408, 3309132, 6383359, 9822661; Product type m : membrane component; succinate dehydrogenase cytochrome b556 large membrane subunit 769929 sdhC 7144441 sdhC Escherichia coli 55989 succinate dehydrogenase cytochrome b556 large membrane subunit YP_002401812.1 769540 D 585055 CDS YP_002401813.1 218694146 7147617 769923..770270 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82124790, 89076355, 9521736, 99414342, 6383359; Product type m : membrane component; succinate dehydrogenase cytochrome b556 small membrane subunit 770270 sdhD 7147617 sdhD Escherichia coli 55989 succinate dehydrogenase cytochrome b556 small membrane subunit YP_002401813.1 769923 D 585055 CDS YP_002401814.1 218694147 7147618 770270..772036 1 NC_011748.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 772036 sdhA 7147618 sdhA Escherichia coli 55989 succinate dehydrogenase flavoprotein subunit YP_002401814.1 770270 D 585055 CDS YP_002401815.1 218694148 7147615 772052..772768 1 NC_011748.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 772768 sdhB 7147615 sdhB Escherichia coli 55989 succinate dehydrogenase iron-sulfur subunit YP_002401815.1 772052 D 585055 CDS YP_002401816.1 218694149 7147616 772969..775770 1 NC_011748.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 775770 sucA 7147616 sucA Escherichia coli 55989 2-oxoglutarate dehydrogenase E1 YP_002401816.1 772969 D 585055 CDS YP_002401817.1 218694150 7147726 775785..777002 1 NC_011748.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 777002 sucB 7147726 sucB Escherichia coli 55989 dihydrolipoamide succinyltransferase YP_002401817.1 775785 D 585055 CDS YP_002401818.1 218694151 7147727 777096..778262 1 NC_011748.1 catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 778262 sucC 7147727 sucC Escherichia coli 55989 succinyl-CoA synthetase subunit beta YP_002401818.1 777096 D 585055 CDS YP_002401819.1 218694152 7147728 778262..779131 1 NC_011748.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 779131 sucD 7147728 sucD Escherichia coli 55989 succinyl-CoA synthetase subunit alpha YP_002401819.1 778262 D 585055 CDS YP_002401820.1 218694153 7147575 complement(779235..779957) 1 NC_011748.1 regulates the succiny-lCoA synthetase operon; DNA-binding transcriptional repressor MngR 779957 mngR 7147575 mngR Escherichia coli 55989 DNA-binding transcriptional repressor MngR YP_002401820.1 779235 R 585055 CDS YP_002401821.1 218694154 7146869 780066..782042 1 NC_011748.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC 782042 mngA 7146869 mngA Escherichia coli 55989 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC YP_002401821.1 780066 D 585055 CDS YP_002401822.1 218694155 7146867 782060..784693 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14645248, 9063979; Product type e : enzyme; alpha-mannosidase 784693 mngB 7146867 mngB Escherichia coli 55989 alpha-mannosidase YP_002401822.1 782060 D 585055 CDS YP_002401823.1 218694156 7146868 784718..784945 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 784945 7146868 EC55989_0716 Escherichia coli 55989 hypothetical protein YP_002401823.1 784718 D 585055 CDS YP_002401824.1 218694157 7144442 785540..787108 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 1689724, 1724280, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase, subunit I 787108 cydA 7144442 cydA Escherichia coli 55989 cytochrome d terminal oxidase, subunit I YP_002401824.1 785540 D 585055 CDS YP_002401825.1 218694158 7145807 787124..788263 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase, subunit II 788263 cydB 7145807 cydB Escherichia coli 55989 cytochrome d terminal oxidase, subunit II YP_002401825.1 787124 D 585055 CDS YP_002401826.1 218694159 7145808 788391..788684 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 788684 ybgE 7145808 ybgE Escherichia coli 55989 hypothetical protein YP_002401826.1 788391 D 585055 CDS YP_002401827.1 218694160 7148173 788834..789238 1 NC_011748.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase 789238 ybgC 7148173 ybgC Escherichia coli 55989 acyl-CoA thioester hydrolase YP_002401827.1 788834 D 585055 CDS YP_002401828.1 218694161 7148172 789235..789927 1 NC_011748.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 789927 tolQ 7148172 tolQ Escherichia coli 55989 colicin uptake protein TolQ YP_002401828.1 789235 D 585055 CDS YP_002401829.1 218694162 7147815 789931..790359 1 NC_011748.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 790359 tolR 7147815 tolR Escherichia coli 55989 colicin uptake protein TolR YP_002401829.1 789931 D 585055 CDS YP_002401830.1 218694163 7147816 790424..791689 1 NC_011748.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 791689 tolA 7147816 tolA Escherichia coli 55989 cell envelope integrity inner membrane protein TolA YP_002401830.1 790424 D 585055 CDS YP_002401831.1 218694164 7147811 791822..793114 1 NC_011748.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 793114 tolB 7147811 tolB Escherichia coli 55989 translocation protein TolB YP_002401831.1 791822 D 585055 CDS YP_002401832.1 218694165 7147813 793149..793670 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790745, 87133578, 92244043, 99403391, 11173492, 2687247; Product type lp : lipoprotein; peptidoglycan-associated outer membrane lipoprotein 793670 pal 7147813 pal Escherichia coli 55989 peptidoglycan-associated outer membrane lipoprotein YP_002401832.1 793149 D 585055 CDS YP_002401833.1 218694166 7147109 793680..794471 1 NC_011748.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 794471 ybgF 7147109 ybgF Escherichia coli 55989 tol-pal system protein YbgF YP_002401833.1 793680 D 585055 CDS YP_002401834.1 218694167 7145322 795940..796983 1 NC_011748.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 796983 nadA 7145322 nadA Escherichia coli 55989 quinolinate synthetase YP_002401834.1 795940 D 585055 CDS YP_002401835.1 218694168 7146942 797021..797740 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 219824, 90330519; Product type t : transporter; nicotinamide mononucleotide transporter 797740 pnuC 7146942 pnuC Escherichia coli 55989 nicotinamide mononucleotide transporter YP_002401835.1 797021 D 585055 CDS YP_002401836.1 218694169 7147206 complement(797737..798678) 1 NC_011748.1 involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB 798678 zitB 7147206 zitB Escherichia coli 55989 zinc transporter ZitB YP_002401836.1 797737 R 585055 CDS YP_002401837.1 218694170 7149489 complement(798792..799172) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 799172 ybgS 7149489 ybgS Escherichia coli 55989 hypothetical protein YP_002401837.1 798792 R 585055 CDS YP_002401838.1 218694171 7148183 799488..800540 1 NC_011748.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 800540 aroG 7148183 aroG Escherichia coli 55989 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002401838.1 799488 D 585055 CDS YP_002401839.1 218694172 7145545 complement(800698..801450) 1 NC_011748.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase 801450 gpmA 7145545 gpmA Escherichia coli 55989 phosphoglyceromutase YP_002401839.1 800698 R 585055 CDS YP_002401840.1 218694173 7146360 complement(801655..802695) 1 NC_011748.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase 802695 galM 7146360 galM Escherichia coli 55989 aldose 1-epimerase YP_002401840.1 801655 R 585055 CDS YP_002401841.1 218694174 7146250 complement(802689..803837) 1 NC_011748.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase 803837 galK 7146250 galK Escherichia coli 55989 galactokinase YP_002401841.1 802689 R 585055 CDS YP_002401842.1 218694175 7146249 complement(803841..804887) 1 NC_011748.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase 804887 galT 7146249 galT Escherichia coli 55989 galactose-1-phosphate uridylyltransferase YP_002401842.1 803841 R 585055 CDS YP_002401843.1 218694176 7146254 complement(804897..805913) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89274199, 92253563, 92338916, 3022232, 6301942, 8564363, 8611559, 8931134, 9174344, 9271499, 9708982; Product type e : enzyme; UDP-galactose-4-epimerase 805913 galE 7146254 galE Escherichia coli 55989 UDP-galactose-4-epimerase YP_002401843.1 804897 R 585055 CDS YP_002401844.1 218694177 7146247 complement(806174..807646) 1 NC_011748.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF 807646 modF 7146247 modF Escherichia coli 55989 molybdenum transport ATP-binding protein ModF YP_002401844.1 806174 R 585055 CDS YP_002401845.1 218694178 7146883 complement(807574..807720) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 807720 7146883 EC55989_0740 Escherichia coli 55989 hypothetical protein YP_002401845.1 807574 R 585055 CDS YP_002401846.1 218694179 7144443 complement(807714..808502) 1 NC_011748.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE 808502 modE 7144443 modE Escherichia coli 55989 DNA-binding transcriptional regulator ModE YP_002401846.1 807714 R 585055 CDS YP_002401847.1 218694180 7146882 808631..808780 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 808780 ybhT 7146882 ybhT Escherichia coli 55989 hypothetical protein YP_002401847.1 808631 D 585055 CDS YP_002401848.1 218694181 7148202 808947..809720 1 NC_011748.1 with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 809720 modA 7148202 modA Escherichia coli 55989 molybdate transporter periplasmic protein YP_002401848.1 808947 D 585055 CDS YP_002401849.1 218694182 7146879 809720..810409 1 NC_011748.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 810409 modB 7146879 modB Escherichia coli 55989 molybdate ABC transporter permease YP_002401849.1 809720 D 585055 CDS YP_002401850.1 218694183 7146880 810412..811470 1 NC_011748.1 Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 811470 modC 7146880 modC Escherichia coli 55989 molybdate transporter ATP-binding protein YP_002401850.1 810412 D 585055 CDS YP_002401851.1 218694184 7146881 complement(811471..812289) 1 NC_011748.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase 812289 ybhA 7146881 ybhA Escherichia coli 55989 phosphotransferase YP_002401851.1 811471 R 585055 CDS YP_002401852.1 218694185 7148184 812444..813439 1 NC_011748.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 813439 pgl 7148184 pgl Escherichia coli 55989 6-phosphogluconolactonase YP_002401852.1 812444 D 585055 CDS YP_002401853.1 218694186 7148187 814238..814513 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 814513 insA 7148187 insA Escherichia coli 55989 IS1 repressor protein InsA YP_002401853.1 814238 D 585055 CDS YP_002401854.1 218694187 7146570 814432..814935 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 814935 insB 7146570 insB Escherichia coli 55989 IS1 transposase InsAB' YP_002401854.1 814432 D 585055 CDS YP_002401855.1 218694188 7148190 815697..817130 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; anion transporter 817130 ybhI 7148190 ybhI Escherichia coli 55989 anion transporter YP_002401855.1 815697 D 585055 CDS YP_002401856.1 218694189 7148191 817313..819574 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11782506; Product type pe : enzyme; hypothetical protein 819574 ybhJ 7148191 ybhJ Escherichia coli 55989 hypothetical protein YP_002401856.1 817313 D 585055 CDS YP_002401857.1 218694190 7148192 complement(819808..821091) 1 NC_011748.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family; pectinesterase 821091 ybhC 7148192 ybhC Escherichia coli 55989 pectinesterase YP_002401857.1 819808 R 585055 CDS YP_002401858.1 218694191 7148186 complement(821226..822296) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6446713; Product type h : extrachromosomal origin; Integrase from phage 822296 int 7148186 int Escherichia coli 55989 Integrase from phage YP_002401858.1 821226 R 585055 CDS YP_002401859.1 218694192 7146602 822920..823123 1 NC_011748.1 hypothetical protein 823123 7146602 EC55989_0757 Escherichia coli 55989 hypothetical protein YP_002401859.1 822920 D 585055 CDS YP_002401860.1 218694193 7144444 complement(823755..823976) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 823976 7144444 EC55989_0758 Escherichia coli 55989 hypothetical protein YP_002401860.1 823755 R 585055 CDS YP_002401861.1 218694194 7144445 complement(824075..824386) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 824386 7144445 EC55989_0759 Escherichia coli 55989 hypothetical protein YP_002401861.1 824075 R 585055 CDS YP_002401862.1 218694195 7144446 complement(824367..824558) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 824558 7144446 EC55989_0761 Escherichia coli 55989 phage protein YP_002401862.1 824367 R 585055 CDS YP_002401863.1 218694196 7144447 complement(824710..825390) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; exonuclease from phage origin 825390 7144447 EC55989_0762 Escherichia coli 55989 exonuclease from phage origin YP_002401863.1 824710 R 585055 CDS YP_002401864.1 218694197 7144448 complement(825387..826172) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 6458018, 6221115; Product type h : extrachromosomal origin; Recombination protein bet from phage origin 826172 7144448 EC55989_0763 Escherichia coli 55989 Recombination protein bet from phage origin YP_002401864.1 825387 R 585055 CDS YP_002401865.1 218694198 7144449 complement(826178..826474) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; host-nuclease inhibitor protein Gam of bacteriophage 826474 7144449 EC55989_0764 Escherichia coli 55989 host-nuclease inhibitor protein Gam of bacteriophage YP_002401865.1 826178 R 585055 CDS YP_002401866.1 218694199 7144451 complement(827354..828109) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Regulatory protein CI from bacteriophage origin 828109 7144451 EC55989_0766 Escherichia coli 55989 Regulatory protein CI from bacteriophage origin YP_002401866.1 827354 R 585055 CDS YP_002401867.1 218694200 7144452 828148..828378 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Cro 828378 cro 7144452 cro Escherichia coli 55989 Cro YP_002401867.1 828148 D 585055 CDS YP_002401868.1 218694201 7145758 828448..828987 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 612476; Product type h : extrachromosomal origin; Regulatory protein CII (modular protein) from bacteriophage origin; coiled-coil 828987 7145758 EC55989_0768 Escherichia coli 55989 Regulatory protein CII (modular protein) from bacteriophage origin; coiled-coil YP_002401868.1 828448 D 585055 CDS YP_002401869.1 218694202 7144453 828984..830003 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2995831; Product type h : extrachromosomal origin; Replication protein O frm phage origin 830003 7144453 EC55989_0769 Escherichia coli 55989 Replication protein O frm phage origin YP_002401869.1 828984 D 585055 CDS YP_002401870.1 218694203 7144454 830000..830701 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; replication protein P of bacteriophage 830701 7144454 EC55989_0770 Escherichia coli 55989 replication protein P of bacteriophage YP_002401870.1 830000 D 585055 CDS YP_002401871.1 218694204 7144455 830698..831000 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Ren protein from phage origin 831000 7144455 EC55989_0771 Escherichia coli 55989 Ren protein from phage origin YP_002401871.1 830698 D 585055 CDS YP_002401872.1 218694205 7144456 831068..831400 1 NC_011748.1 member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein 831400 emrE 7144456 emrE Escherichia coli 55989 multidrug efflux protein YP_002401872.1 831068 D 585055 CDS YP_002401873.1 218694206 7145992 831656..833182 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; site-specific invertase; DLP12 prophage 833182 ybcK 7145992 ybcK Escherichia coli 55989 site-specific invertase; DLP12 prophage YP_002401873.1 831656 D 585055 CDS YP_002401874.1 218694207 7148129 833179..833355 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 833355 7148129 EC55989_0774 Escherichia coli 55989 hypothetical protein YP_002401874.1 833179 D 585055 CDS YP_002401875.1 218694208 7144458 833852..834361 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 834361 7144458 EC55989_0776 Escherichia coli 55989 hypothetical protein YP_002401875.1 833852 D 585055 CDS YP_002401876.1 218694209 7144459 834556..835011 1 NC_011748.1 DLP12 prophage; hypothetical protein 835011 ybcN 7144459 ybcN Escherichia coli 55989 hypothetical protein YP_002401876.1 834556 D 585055 CDS YP_002401877.1 218694210 7148132 835011..835181 1 NC_011748.1 DLP12 prophage; conserved protein similar to phage 82 and lambda proteins; prophage protein NinE 835181 ninE 7148132 ninE Escherichia coli 55989 prophage protein NinE YP_002401877.1 835011 D 585055 CDS YP_002401878.1 218694211 7147001 835174..835464 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; DLP12 prophage 835464 ybcO 7147001 ybcO Escherichia coli 55989 DLP12 prophage YP_002401878.1 835174 D 585055 CDS YP_002401879.1 218694212 7147559 836045..836428 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8648624, 9278503; Product type pf : factor; antitermination protein Q 836428 ybcQ 7147559 ybcQ Escherichia coli 55989 antitermination protein Q YP_002401879.1 836045 D 585055 CDS YP_002401880.1 218694213 7148134 complement(836617..837699) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 3017988, 8057841; Product type m : membrane component; outer membrane porin; DLP12 prophage 837699 nmpC 7148134 nmpC Escherichia coli 55989 outer membrane porin; DLP12 prophage YP_002401880.1 836617 R 585055 CDS YP_002401881.1 218694214 7147012 838288..838503 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : enzyme; phage lysis protein S; DLP12 prophage 838503 essD 7147012 essD Escherichia coli 55989 phage lysis protein S; DLP12 prophage YP_002401881.1 838288 D 585055 CDS YP_002401882.1 218694215 7146023 838503..839000 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3017988; Product type pe : enzyme; lysozyme; DLP12 prophage 839000 ybcS 7146023 ybcS Escherichia coli 55989 lysozyme; DLP12 prophage YP_002401882.1 838503 D 585055 CDS YP_002401883.1 218694216 7148135 838985..839434 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; bacteriophage lysis protein 839434 7148135 EC55989_0785 Escherichia coli 55989 bacteriophage lysis protein YP_002401883.1 838985 D 585055 CDS YP_002401884.1 218694217 7144460 839640..840161 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 840161 7144460 EC55989_0786 Escherichia coli 55989 phage protein YP_002401884.1 839640 D 585055 CDS YP_002401885.1 218694218 7144461 complement(840511..840936) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 840936 7144461 EC55989_0787 Escherichia coli 55989 phage protein YP_002401885.1 840511 R 585055 CDS YP_002401886.1 218694219 7144462 complement(840978..841211) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage 841211 ynfO 7144462 ynfO Escherichia coli 55989 Qin prophage YP_002401886.1 840978 R 585055 CDS YP_002401887.1 218694220 7149321 841600..842145 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92334985; Product type h : extrachromosomal origin; DNA packaging protein; DLP12 prophage 842145 nohB 7149321 nohB Escherichia coli 55989 DNA packaging protein; DLP12 prophage YP_002401887.1 841600 D 585055 CDS YP_002401888.1 218694221 7147013 842120..843781 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Terminase large subunit from bacteriophage origin 843781 A 7147013 A Escherichia coli 55989 Terminase large subunit from bacteriophage origin YP_002401888.1 842120 D 585055 CDS YP_002401889.1 218694222 7144463 844041..844247 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11302702; Product type h : extrachromosomal origin; Head-to-tail joining protein W (gpW) from bacteriophage origin 844247 W 7144463 W Escherichia coli 55989 Head-to-tail joining protein W (gpW) from bacteriophage origin YP_002401889.1 844041 D 585055 CDS YP_002401890.1 218694223 7147954 844244..845845 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Portal protein; minor capsid protein [Contains: Protein B*] from bacteriophage origin 845845 B 7147954 B Escherichia coli 55989 Portal protein; minor capsid protein [Contains: Protein B*] from bacteriophage origin YP_002401890.1 844244 D 585055 CDS YP_002401891.1 218694224 7145591 845691..847145 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; Minor capsid protein C from bacteriophage origin 847145 C 7145591 C Escherichia coli 55989 Minor capsid protein C from bacteriophage origin YP_002401891.1 845691 D 585055 CDS YP_002401892.1 218694225 7145645 847149..847487 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Head decoration protein from bacteriophage origin 847487 D 7145645 D Escherichia coli 55989 Head decoration protein from bacteriophage origin YP_002401892.1 847149 D 585055 CDS YP_002401893.1 218694226 7145839 847516..848568 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Major head coat protein from bacteriophage origin 848568 E 7145839 E Escherichia coli 55989 Major head coat protein from bacteriophage origin YP_002401893.1 847516 D 585055 CDS YP_002401894.1 218694227 7145965 848571..849005 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; DNA packaging protein from bacteriophage origin 849005 fI 7145965 fI Escherichia coli 55989 DNA packaging protein from bacteriophage origin YP_002401894.1 848571 D 585055 CDS YP_002401895.1 218694228 7146105 849017..849370 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; Tail attachment protein (Minor capsid protein FII) from bacteriophage origin 849370 fII 7146105 fII Escherichia coli 55989 Tail attachment protein (Minor capsid protein FII) from bacteriophage origin YP_002401895.1 849017 D 585055 CDS YP_002401896.1 218694229 7146109 849382..849960 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein Z (GpZ) 849960 7146109 EC55989_0799 Escherichia coli 55989 Minor tail protein Z (GpZ) YP_002401896.1 849382 D 585055 CDS YP_002401897.1 218694230 7144464 849957..850352 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein U 850352 7144464 EC55989_0800 Escherichia coli 55989 Minor tail protein U YP_002401897.1 849957 D 585055 CDS YP_002401898.1 218694231 7144465 850330..851100 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail protein V 851100 7144465 EC55989_0801 Escherichia coli 55989 Major tail protein V YP_002401898.1 850330 D 585055 CDS YP_002401899.1 218694232 7144466 851116..851538 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein G 851538 7144466 EC55989_0802 Escherichia coli 55989 Minor tail protein G YP_002401899.1 851116 D 585055 CDS YP_002401900.1 218694233 7144467 851520..851954 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein T 851954 7144467 EC55989_0803 Escherichia coli 55989 Minor tail protein T YP_002401900.1 851520 D 585055 CDS YP_002401901.1 218694234 7144468 851947..854508 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein precursor H 854508 7144468 EC55989_0804 Escherichia coli 55989 Minor tail protein precursor H YP_002401901.1 851947 D 585055 CDS YP_002401902.1 218694235 7144469 854505..854834 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein M 854834 7144469 EC55989_0805 Escherichia coli 55989 Minor tail protein M YP_002401902.1 854505 D 585055 CDS YP_002401903.1 218694236 7144470 854834..855532 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein L 855532 7144470 EC55989_0806 Escherichia coli 55989 Minor tail protein L YP_002401903.1 854834 D 585055 CDS YP_002401904.1 218694237 7144471 855538..856281 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber component K of prophage 856281 7144471 EC55989_0807 Escherichia coli 55989 tail fiber component K of prophage YP_002401904.1 855538 D 585055 CDS YP_002401905.1 218694238 7144472 856179..856850 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail assembly protein I 856850 7144472 EC55989_0808 Escherichia coli 55989 Tail assembly protein I YP_002401905.1 856179 D 585055 CDS YP_002401906.1 218694239 7144473 856911..860408 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J of prophage 860408 7144473 EC55989_0809 Escherichia coli 55989 Host specificity protein J of prophage YP_002401906.1 856911 D 585055 CDS YP_002401907.1 218694240 7144474 860479..861078 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; Lom-like outer membrane protein of phage origin 861078 7144474 EC55989_0810 Escherichia coli 55989 Lom-like outer membrane protein of phage origin YP_002401907.1 860479 D 585055 CDS YP_002401908.1 218694241 7144475 861137..864217 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber protein 864217 7144475 EC55989_0811 Escherichia coli 55989 tail fiber protein YP_002401908.1 861137 D 585055 CDS YP_002401909.1 218694242 7144476 864217..864801 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; tail fiber chaperone; Qin prophage 864801 tfaQ 7144476 tfaQ Escherichia coli 55989 tail fiber chaperone; Qin prophage YP_002401909.1 864217 D 585055 CDS YP_002401910.1 218694243 7147777 complement(864875..866206) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; membrane protein 866206 7147777 EC55989_0813 Escherichia coli 55989 membrane protein YP_002401910.1 864875 R 585055 CDS YP_002401911.1 218694244 7144477 866103..866297 1 NC_011748.1 hypothetical protein 866297 7144477 EC55989_0814 Escherichia coli 55989 hypothetical protein YP_002401911.1 866103 D 585055 CDS YP_002401912.1 218694245 7144478 866562..866735 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 866735 7144478 EC55989_0815 Escherichia coli 55989 hypothetical protein YP_002401912.1 866562 D 585055 CDS YP_002401913.1 218694246 7144479 complement(866952..867428) 1 NC_011748.1 YbhB; similar to rat and human kinase inhibitory proteins; kinase inhibitor protein 867428 ybhB 7144479 ybhB Escherichia coli 55989 kinase inhibitor protein YP_002401913.1 866952 R 585055 CDS YP_002401914.1 218694247 7148185 complement(867487..868776) 1 NC_011748.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase 868776 bioA 7148185 bioA Escherichia coli 55989 adenosylmethionine-8-amino-7-oxononanoate aminotransferase YP_002401914.1 867487 R 585055 CDS YP_002401915.1 218694248 7145624 868863..869903 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11834738, 12475249, 14704425, 14967041, 20250955, 89066784, 94170810, 94190882, 97382445, 11686925; Product type e : enzyme; biotin synthase 869903 bioB 7145624 bioB Escherichia coli 55989 biotin synthase YP_002401915.1 868863 D 585055 CDS YP_002401916.1 218694249 7145625 869900..871054 1 NC_011748.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 871054 bioF 7145625 bioF Escherichia coli 55989 8-amino-7-oxononanoate synthase YP_002401916.1 869900 D 585055 CDS YP_002401917.1 218694250 7145628 871041..871796 1 NC_011748.1 methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 871796 bioC 7145628 bioC Escherichia coli 55989 biotin biosynthesis protein BioC YP_002401917.1 871041 D 585055 CDS YP_002401918.1 218694251 7145626 871789..872466 1 NC_011748.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 872466 bioD 7145626 bioD Escherichia coli 55989 dithiobiotin synthetase YP_002401918.1 871789 D 585055 CDS YP_002401919.1 218694252 7145627 873045..875066 1 NC_011748.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 875066 uvrB 7145627 uvrB Escherichia coli 55989 excinuclease ABC subunit B YP_002401919.1 873045 D 585055 CDS YP_002401920.1 218694253 7147934 complement(875258..876166) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16272399; Product type pe : enzyme; transferase with NAD(P)-binding Rossmann-fold domain; UPF0052 family 876166 ybhK 7147934 ybhK Escherichia coli 55989 transferase with NAD(P)-binding Rossmann-fold domain; UPF0052 family YP_002401920.1 875258 R 585055 CDS YP_002401921.1 218694254 7148193 876563..877552 1 NC_011748.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 877552 moaA 7148193 moaA Escherichia coli 55989 molybdenum cofactor biosynthesis protein A YP_002401921.1 876563 D 585055 CDS YP_002401922.1 218694255 7146872 877574..878086 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93368423; Product type pf : factor; molybdopterin biosynthesis protein B 878086 moaB 7146872 moaB Escherichia coli 55989 molybdopterin biosynthesis protein B YP_002401922.1 877574 D 585055 CDS YP_002401923.1 218694256 7146873 878089..878574 1 NC_011748.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 878574 moaC 7146873 moaC Escherichia coli 55989 molybdenum cofactor biosynthesis protein MoaC YP_002401923.1 878089 D 585055 CDS YP_002401924.1 218694257 7146874 878567..878812 1 NC_011748.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 878812 moaD 7146874 moaD Escherichia coli 55989 molybdopterin synthase small subunit YP_002401924.1 878567 D 585055 CDS YP_002401925.1 218694258 7146875 878814..879266 1 NC_011748.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 879266 moaE 7146875 moaE Escherichia coli 55989 molybdopterin guanine dinucleotide biosynthesis protein MoaE YP_002401925.1 878814 D 585055 CDS YP_002401926.1 218694259 7146876 879403..880107 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 880107 ybhL 7146876 ybhL Escherichia coli 55989 inner membrane protein YP_002401926.1 879403 D 585055 CDS YP_002401927.1 218694260 7148194 880252..880956 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; integral membrane protein 880956 7148194 EC55989_0830 Escherichia coli 55989 integral membrane protein YP_002401927.1 880252 D 585055 CDS YP_002401928.1 218694261 7144480 881026..881739 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 881739 ybhM 7144480 ybhM Escherichia coli 55989 inner membrane protein YP_002401928.1 881026 D 585055 CDS YP_002401929.1 218694262 7148195 complement(881775..882731) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 882731 ybhN 7148195 ybhN Escherichia coli 55989 inner membrane protein YP_002401929.1 881775 R 585055 CDS YP_002401930.1 218694263 7148196 complement(882731..883972) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20102623, 10634942; Product type e : enzyme; cardiolipin synthase 2 883972 ybhO 7148196 ybhO Escherichia coli 55989 cardiolipin synthase 2 YP_002401930.1 882731 R 585055 CDS YP_002401931.1 218694264 7148197 complement(883969..884730) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; metal-dependent hydrolase 884730 ybhP 7148197 ybhP Escherichia coli 55989 metal-dependent hydrolase YP_002401931.1 883969 R 585055 CDS YP_002401932.1 218694265 7148198 884863..885273 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 885273 ybhQ 7148198 ybhQ Escherichia coli 55989 inner membrane protein YP_002401932.1 884863 D 585055 CDS YP_002401933.1 218694266 7148199 complement(885235..886341) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: permease component of ABC superfamily 886341 ybhR 7148199 ybhR Escherichia coli 55989 transporter subunit: permease component of ABC superfamily YP_002401933.1 885235 R 585055 CDS YP_002401934.1 218694267 7148200 complement(886352..887485) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: permease component of ABC superfamily 887485 ybhS 7148200 ybhS Escherichia coli 55989 transporter subunit: permease component of ABC superfamily YP_002401934.1 886352 R 585055 CDS YP_002401935.1 218694268 7148201 complement(887478..889214) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter fused subunits of ABC superfamily: ATP-binding components 889214 ybhF 7148201 ybhF Escherichia coli 55989 transporter fused subunits of ABC superfamily: ATP-binding components YP_002401935.1 887478 R 585055 CDS YP_002401936.1 218694269 7148188 complement(889207..890205) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16092522; Product type pt : transporter; hypothetical protein 890205 ybhG 7148188 ybhG Escherichia coli 55989 hypothetical protein YP_002401936.1 889207 R 585055 CDS YP_002401937.1 218694270 7148189 complement(890205..890876) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 890876 ybiH 7148189 ybiH Escherichia coli 55989 DNA-binding transcriptional regulator YP_002401937.1 890205 R 585055 CDS YP_002401938.1 218694271 7148206 891105..892469 1 NC_011748.1 this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 892469 rhlE 7148206 rhlE Escherichia coli 55989 ATP-dependent RNA helicase RhlE YP_002401938.1 891105 D 585055 CDS YP_002401939.1 218694272 7147397 complement(892701..893183) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 893183 ybiA 7147397 ybiA Escherichia coli 55989 hypothetical protein YP_002401939.1 892701 R 585055 CDS YP_002401940.1 218694273 7148203 893303..895453 1 NC_011748.1 helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 895453 dinG 7148203 dinG Escherichia coli 55989 ATP-dependent DNA helicase DinG YP_002401940.1 893303 D 585055 CDS YP_002401941.1 218694274 7145917 895481..896443 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; glycosyl transferase family protein 896443 ybiB 7145917 ybiB Escherichia coli 55989 glycosyl transferase family protein YP_002401941.1 895481 D 585055 CDS YP_002401942.1 218694275 7148204 896584..897669 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8405966; Product type pe : enzyme; hypothetical protein 897669 ybiC 7148204 ybiC Escherichia coli 55989 hypothetical protein YP_002401942.1 896584 D 585055 CDS YP_002401943.1 218694276 7148205 complement(897898..898158) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 898158 ybiJ 7148205 ybiJ Escherichia coli 55989 hypothetical protein YP_002401943.1 897898 R 585055 CDS YP_002401944.1 218694277 7148208 complement(898423..898689) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 898689 ybiI 7148208 ybiI Escherichia coli 55989 hypothetical protein YP_002401944.1 898423 R 585055 CDS YP_002401945.1 218694278 7148207 complement(898763..899440) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hydroxylase 899440 ybiX 7148207 ybiX Escherichia coli 55989 hydroxylase YP_002401945.1 898763 R 585055 CDS YP_002401946.1 218694279 7148219 complement(899482..901764) 1 NC_011748.1 Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu 901764 fiu 7148219 fiu Escherichia coli 55989 catecholate siderophore receptor Fiu YP_002401946.1 899482 R 585055 CDS YP_002401947.1 218694280 7146114 complement(902029..902433) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 902433 ybiM 7146114 ybiM Escherichia coli 55989 hypothetical protein YP_002401947.1 902029 R 585055 CDS YP_002401948.1 218694281 7148209 902565..903491 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; SAM-dependent methyltransferase 903491 ybiN 7148209 ybiN Escherichia coli 55989 SAM-dependent methyltransferase YP_002401948.1 902565 D 585055 CDS YP_002401949.1 218694282 7148210 complement(903488..905713) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; hypothetical protein 905713 ybiO 7148210 ybiO Escherichia coli 55989 hypothetical protein YP_002401949.1 903488 R 585055 CDS YP_002401950.1 218694283 7148211 complement(905830..906552) 1 NC_011748.1 similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein 906552 glnQ 7148211 glnQ Escherichia coli 55989 glutamine ABC transporter ATP-binding protein YP_002401950.1 905830 R 585055 CDS YP_002401951.1 218694284 7146311 complement(906549..907208) 1 NC_011748.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease 907208 glnP 7146311 glnP Escherichia coli 55989 glutamine ABC transporter permease YP_002401951.1 906549 R 585055 CDS YP_002401952.1 218694285 7146310 complement(907347..908093) 1 NC_011748.1 similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein 908093 glnH 7146310 glnH Escherichia coli 55989 glutamine ABC transporter periplasmic protein YP_002401952.1 907347 R 585055 CDS YP_002401953.1 218694286 7146307 complement(908497..909000) 1 NC_011748.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps 909000 dps 7146307 dps Escherichia coli 55989 DNA starvation/stationary phase protection protein Dps YP_002401953.1 908497 R 585055 CDS YP_002401954.1 218694287 7145949 complement(909299..910186) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12648727, 8021175; Product type t : transporter; threonine and homoserine efflux system 910186 rhtA 7145949 rhtA Escherichia coli 55989 threonine and homoserine efflux system YP_002401954.1 909299 R 585055 CDS YP_002401955.1 218694288 7147406 910539..911054 1 NC_011748.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 911054 ompX 7147406 ompX Escherichia coli 55989 outer membrane protein X YP_002401955.1 910539 D 585055 CDS YP_002401956.1 218694289 7147072 complement(911103..912686) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16514146; Product type pe : enzyme; enzyme, UPF0141 family, inner membrane 912686 ybiP 7147072 ybiP Escherichia coli 55989 enzyme, UPF0141 family, inner membrane YP_002401956.1 911103 R 585055 CDS YP_002401957.1 218694290 7147572 913272..913739 1 NC_011748.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 913739 mntR 7147572 mntR Escherichia coli 55989 manganese transport regulator MntR YP_002401957.1 913272 D 585055 CDS YP_002401958.1 218694291 7146871 913736..914854 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 914854 ybiR 7146871 ybiR Escherichia coli 55989 transporter YP_002401958.1 913736 D 585055 CDS YP_002401959.1 218694292 7148213 complement(914913..915833) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10493123, 9298646; hypothetical protein 915833 ybiS 7148213 ybiS Escherichia coli 55989 hypothetical protein YP_002401959.1 914913 R 585055 CDS YP_002401960.1 218694293 7148214 916052..917644 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11916677; Product type pt : transporter; transporter fused subunits of ABC superfamily: ATP-binding components 917644 ybiT 7148214 ybiT Escherichia coli 55989 transporter fused subunits of ABC superfamily: ATP-binding components YP_002401960.1 916052 D 585055 CDS YP_002401961.1 218694294 7148215 917923..918903 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase, IS110 family 918903 7148215 EC55989_0865 Escherichia coli 55989 transposase, IS110 family YP_002401961.1 917923 D 585055 CDS YP_002401962.1 218694295 7144481 complement(919159..920424) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 920424 ybiU 7144481 ybiU Escherichia coli 55989 hypothetical protein YP_002401962.1 919159 R 585055 CDS YP_002401963.1 218694296 7148216 complement(920576..921391) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15657928; Product type e : enzyme; type II HAD phosphatase 921391 ybiV 7148216 ybiV Escherichia coli 55989 type II HAD phosphatase YP_002401963.1 920576 R 585055 CDS YP_002401964.1 218694297 7148217 complement(921537..923969) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16218870; Product type pe : enzyme; glycyl radical cofactor protein 923969 ybiW 7148217 ybiW Escherichia coli 55989 glycyl radical cofactor protein YP_002401964.1 921537 R 585055 CDS YP_002401965.1 218694298 7148218 complement(923975..924901) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15581584; Product type pe : enzyme; AdoMet-dependent glycyl radical activating enzyme 924901 ybiY 7148218 ybiY Escherichia coli 55989 AdoMet-dependent glycyl radical activating enzyme YP_002401965.1 923975 R 585055 CDS YP_002401966.1 218694299 7148220 925005..925667 1 NC_011748.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 925667 fsaA 7148220 fsaA Escherichia coli 55989 fructose-6-phosphate aldolase YP_002401966.1 925005 D 585055 CDS YP_002401967.1 218694300 7146206 complement(925755..926504) 1 NC_011748.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB 926504 moeB 7146206 moeB Escherichia coli 55989 molybdopterin biosynthesis protein MoeB YP_002401967.1 925755 R 585055 CDS YP_002401968.1 218694301 7146885 complement(926504..927739) 1 NC_011748.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA 927739 moeA 7146885 moeA Escherichia coli 55989 molybdopterin biosynthesis protein MoeA YP_002401968.1 926504 R 585055 CDS YP_002401969.1 218694302 7146884 927943..928908 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15159592, 20508248, 3045084, 7984428; Product type e : enzyme; L-asparaginase 928908 iaaA 7146884 iaaA Escherichia coli 55989 L-asparaginase YP_002401969.1 927943 D 585055 CDS YP_002401970.1 218694303 7146528 928928..930766 1 NC_011748.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 930766 yliA 7146528 yliA Escherichia coli 55989 glutathione transporter ATP-binding protein YP_002401970.1 928928 D 585055 CDS YP_002401971.1 218694304 7149252 930786..932324 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pt : transporter; peptide transporter subunit: periplasmic-binding component of ABC superfamily 932324 yliB 7149252 yliB Escherichia coli 55989 peptide transporter subunit: periplasmic-binding component of ABC superfamily YP_002401971.1 930786 D 585055 CDS YP_002401972.1 218694305 7149253 932342..933262 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; peptide transporter permease subunit: membrane component of ABC superfamily 933262 yliC 7149253 yliC Escherichia coli 55989 peptide transporter permease subunit: membrane component of ABC superfamily YP_002401972.1 932342 D 585055 CDS YP_002401973.1 218694306 7149254 933265..934176 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; peptide transporter permease subunit: membrane component of ABC superfamily 934176 yliD 7149254 yliD Escherichia coli 55989 peptide transporter permease subunit: membrane component of ABC superfamily YP_002401973.1 933265 D 585055 CDS YP_002401974.1 218694307 7149255 934354..936702 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 936702 yliE 7149255 yliE Escherichia coli 55989 inner membrane protein YP_002401974.1 934354 D 585055 CDS YP_002401975.1 218694308 7149256 936710..938038 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pe : enzyme; diguanylate cyclase 938038 yliF 7149256 yliF Escherichia coli 55989 diguanylate cyclase YP_002401975.1 936710 D 585055 CDS YP_002401976.1 218694309 7149257 complement(938085..939410) 1 NC_011748.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase 939410 rimO 7149257 rimO Escherichia coli 55989 ribosomal protein S12 methylthiotransferase YP_002401976.1 938085 R 585055 CDS YP_002401977.1 218694310 7149258 939623..940006 1 NC_011748.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 940006 bssR 7149258 bssR Escherichia coli 55989 biofilm formation regulatory protein BssR YP_002401977.1 939623 D 585055 CDS YP_002401978.1 218694311 7145637 940117..941232 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16522795, 16864586; Product type e : enzyme; PQQ-dependent aldose sugar dehydrogenase precursor (asd) 941232 yliI 7145637 yliI Escherichia coli 55989 PQQ-dependent aldose sugar dehydrogenase precursor (asd) YP_002401978.1 940117 D 585055 CDS YP_002401979.1 218694312 7149259 complement(941229..941855) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; glutathione S-transferase 941855 yliJ 7149259 yliJ Escherichia coli 55989 glutathione S-transferase YP_002401979.1 941229 R 585055 CDS YP_002401980.1 218694313 7149260 942102..943304 1 NC_011748.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 943304 dacC 7149260 dacC Escherichia coli 55989 D-alanyl-D-alanine carboxypeptidase YP_002401980.1 942102 D 585055 CDS YP_002401981.1 218694314 7145843 complement(943351..944109) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89231635, 89336786, 92231401, 2994018; Product type r : regulator; DNA-binding transcriptional repressor DeoR 944109 deoR 7145843 deoR Escherichia coli 55989 DNA-binding transcriptional repressor DeoR YP_002401981.1 943351 R 585055 CDS YP_002401982.1 218694315 7145890 complement(944167..944763) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 944763 ybjG 7145890 ybjG Escherichia coli 55989 undecaprenyl pyrophosphate phosphatase YP_002401982.1 944167 R 585055 CDS YP_002401983.1 218694316 7148224 945048..946280 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10022825, 12578981, 14688269, 21217867, 21450803, 9079913, 9644262, 99030337, 8655497; Product type t : transporter; multidrug efflux system protein 946280 cmr 7148224 cmr Escherichia coli 55989 multidrug efflux system protein YP_002401983.1 945048 D 585055 CDS YP_002401984.1 218694317 7145729 complement(946321..946605) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 946605 ybjH 7145729 ybjH Escherichia coli 55989 hypothetical protein YP_002401984.1 946321 R 585055 CDS YP_002401985.1 218694318 7148225 complement(946691..947506) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : enzyme; phosphatase 947506 ybjI 7148225 ybjI Escherichia coli 55989 phosphatase YP_002401985.1 946691 R 585055 CDS YP_002401986.1 218694319 7148226 complement(947506..948714) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 948714 ybjJ 7148226 ybjJ Escherichia coli 55989 transporter YP_002401986.1 947506 R 585055 CDS YP_002401987.1 218694320 7148227 948798..949334 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 949334 ybjK 7148227 ybjK Escherichia coli 55989 DNA-binding transcriptional regulator YP_002401987.1 948798 D 585055 CDS YP_002401988.1 218694321 7147573 complement(949509..951194) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; hypothetical protein 951194 ybjL 7147573 ybjL Escherichia coli 55989 hypothetical protein YP_002401988.1 949509 R 585055 CDS YP_002401989.1 218694322 7148229 951464..951841 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 951841 ybjM 7148229 ybjM Escherichia coli 55989 inner membrane protein YP_002401989.1 951464 D 585055 CDS YP_002401990.1 218694323 7148230 complement(951871..952128) 1 NC_011748.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin 952128 grxA 7148230 grxA Escherichia coli 55989 glutaredoxin YP_002401990.1 951871 R 585055 CDS YP_002401991.1 218694324 7146370 952288..952575 1 NC_011748.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 952575 ybjC 7146370 ybjC Escherichia coli 55989 hypothetical protein YP_002401991.1 952288 D 585055 CDS YP_002401992.1 218694325 7148221 952559..953281 1 NC_011748.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 953281 nfsA 7148221 nfsA Escherichia coli 55989 nitroreductase A YP_002401992.1 952559 D 585055 CDS YP_002401993.1 218694326 7146990 953342..954244 1 NC_011748.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 954244 rimK 7146990 rimK Escherichia coli 55989 ribosomal protein S6 modification protein YP_002401993.1 953342 D 585055 CDS YP_002401994.1 218694327 7147420 954332..954808 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 954808 ybjN 7147420 ybjN Escherichia coli 55989 hypothetical protein YP_002401994.1 954332 D 585055 CDS YP_002401995.1 218694328 7148231 955160..956272 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992, 9651355, 9298646, 8416922; Product type t : transporter; putrescine ABC transporter periplasmic-binding protein 956272 potF 7148231 potF Escherichia coli 55989 putrescine ABC transporter periplasmic-binding protein YP_002401995.1 955160 D 585055 CDS YP_002401996.1 218694329 7147214 956367..957500 1 NC_011748.1 part of the PotFGHI ATP-dependent putrescine transporter; putrescine ABC transporter ATP-binding protein 957500 potG 7147214 potG Escherichia coli 55989 putrescine ABC transporter ATP-binding protein YP_002401996.1 956367 D 585055 CDS YP_002401997.1 218694330 7147215 957510..958466 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter; putrescine ABC transporter membrane protein 958466 potH 7147215 potH Escherichia coli 55989 putrescine ABC transporter membrane protein YP_002401997.1 957510 D 585055 CDS YP_002401998.1 218694331 7147216 958459..959304 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter; putrescine ABC transporter membrane protein 959304 potI 7147216 potI Escherichia coli 55989 putrescine ABC transporter membrane protein YP_002401998.1 958459 D 585055 CDS YP_002401999.1 218694332 7147217 959364..959852 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 959852 ybjO 7147217 ybjO Escherichia coli 55989 inner membrane protein YP_002401999.1 959364 D 585055 CDS YP_002402000.1 218694333 7148232 959893..961020 1 NC_011748.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 961020 rumB 7148232 rumB Escherichia coli 55989 23S rRNA methyluridine methyltransferase YP_002402000.1 959893 D 585055 CDS YP_002402001.1 218694334 7147558 complement(961195..961926) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422; Product type t : transporter; arginine transporter subunit ; periplasmic-binding component of ABC superfamily 961926 artJ 7147558 artJ Escherichia coli 55989 arginine transporter subunit ; periplasmic-binding component of ABC superfamily YP_002402001.1 961195 R 585055 CDS YP_002402002.1 218694335 7145556 complement(962218..962886) 1 NC_011748.1 with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM 962886 artM 7145556 artM Escherichia coli 55989 arginine transporter permease subunit ArtM YP_002402002.1 962218 R 585055 CDS YP_002402003.1 218694336 7145557 complement(962886..963602) 1 NC_011748.1 with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ 963602 artQ 7145557 artQ Escherichia coli 55989 arginine transporter permease subunit ArtQ YP_002402003.1 962886 R 585055 CDS YP_002402004.1 218694337 7145559 complement(963609..964340) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422, 9740056; Product type t : transporter; arginine transporter subunit ; periplasmic-binding component of ABC superfamily 964340 artI 7145559 artI Escherichia coli 55989 arginine transporter subunit ; periplasmic-binding component of ABC superfamily YP_002402004.1 963609 R 585055 CDS YP_002402005.1 218694338 7145555 complement(964358..965086) 1 NC_011748.1 With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit 965086 artP 7145555 artP Escherichia coli 55989 arginine transporter ATP-binding subunit YP_002402005.1 964358 R 585055 CDS YP_002402006.1 218694339 7145558 complement(965304..965819) 1 NC_011748.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; lipoprotein 965819 ybjP 7145558 ybjP Escherichia coli 55989 lipoprotein YP_002402006.1 965304 R 585055 CDS YP_002402007.1 218694340 7148233 965945..966268 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 966268 ybjQ 7148233 ybjQ Escherichia coli 55989 hypothetical protein YP_002402007.1 965945 D 585055 CDS YP_002402008.1 218694341 7148234 966265..967095 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; cell wall amidase and lipoprotein 967095 ybjR 7148234 ybjR Escherichia coli 55989 cell wall amidase and lipoprotein YP_002402008.1 966265 D 585055 CDS YP_002402009.1 218694342 7148235 complement(967092..968105) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain 968105 ybjS 7148235 ybjS Escherichia coli 55989 NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain YP_002402009.1 967092 R 585055 CDS YP_002402010.1 218694343 7148236 complement(968204..969634) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; NAD(P)-binding Rossmann-fold domain 969634 ybjT 7148236 ybjT Escherichia coli 55989 NAD(P)-binding Rossmann-fold domain YP_002402010.1 968204 R 585055 CDS YP_002402011.1 218694344 7148237 complement(969645..970646) 1 NC_011748.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase 970646 ltaE 7148237 ltaE Escherichia coli 55989 L-threonine aldolase YP_002402011.1 969645 R 585055 CDS YP_002402012.1 218694345 7146753 complement(970683..972401) 1 NC_011748.1 catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase 972401 poxB 7146753 poxB Escherichia coli 55989 pyruvate dehydrogenase YP_002402012.1 970683 R 585055 CDS YP_002402013.1 218694346 7147219 complement(972534..973502) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20117674; Product type e : enzyme; HCP oxidoreductase 973502 hcr 7147219 hcr Escherichia coli 55989 HCP oxidoreductase YP_002402013.1 972534 R 585055 CDS YP_002402014.1 218694347 7146399 complement(973514..975166) 1 NC_011748.1 catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase 975166 hcp 7146399 hcp Escherichia coli 55989 hydroxylamine reductase YP_002402014.1 973514 R 585055 CDS YP_002402015.1 218694348 7146398 complement(975310..976209) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 976209 ybjE 7146398 ybjE Escherichia coli 55989 transporter YP_002402015.1 975310 R 585055 CDS YP_002402016.1 218694349 7148223 complement(976704..977399) 1 NC_011748.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z 977399 aqpZ 7148223 aqpZ Escherichia coli 55989 aquaporin Z YP_002402016.1 976704 R 585055 CDS YP_002402017.1 218694350 7145512 977825..979483 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; nucleoside triphosphate hydrolase domain 979483 ybjD 7145512 ybjD Escherichia coli 55989 nucleoside triphosphate hydrolase domain YP_002402017.1 977825 D 585055 CDS YP_002402018.1 218694351 7148222 complement(979480..980472) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 980472 ybjX 7148222 ybjX Escherichia coli 55989 hypothetical protein YP_002402018.1 979480 R 585055 CDS YP_002402019.1 218694352 7148238 980587..981702 1 NC_011748.1 confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 981702 macA 7148238 macA Escherichia coli 55989 macrolide transporter subunit MacA YP_002402019.1 980587 D 585055 CDS YP_002402020.1 218694353 7146764 981699..983645 1 NC_011748.1 with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 983645 macB 7146764 macB Escherichia coli 55989 macrolide transporter ATP-binding /permease YP_002402020.1 981699 D 585055 CDS YP_002402021.1 218694354 7146765 complement(983718..983942) 1 NC_011748.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD 983942 cspD 7146765 cspD Escherichia coli 55989 stationary phase/starvation inducible regulatory protein CspD YP_002402021.1 983718 R 585055 CDS YP_002402022.1 218694355 7145779 984265..984585 1 NC_011748.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 984585 clpS 7145779 clpS Escherichia coli 55989 ATP-dependent Clp protease adaptor protein ClpS YP_002402022.1 984265 D 585055 CDS YP_002402023.1 218694356 7145725 984616..986892 1 NC_011748.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 986892 clpA 7145725 clpA Escherichia coli 55989 ATP-dependent Clp protease ATP-binding subunit YP_002402023.1 984616 D 585055 CDS YP_002402024.1 218694357 7145402 complement(987576..987794) 1 NC_011748.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 987794 infA 7145402 infA Escherichia coli 55989 translation initiation factor IF-1 YP_002402024.1 987576 R 585055 CDS YP_002402025.1 218694358 7146565 complement(988079..988783) 1 NC_011748.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase 988783 aat 7146565 aat Escherichia coli 55989 leucyl/phenylalanyl-tRNA--protein transferase YP_002402025.1 988079 R 585055 CDS YP_002402026.1 218694359 7145421 complement(988825..990546) 1 NC_011748.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 990546 cydC 7145421 cydC Escherichia coli 55989 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_002402026.1 988825 R 585055 CDS YP_002402027.1 218694360 7145809 complement(990547..992313) 1 NC_011748.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein 992313 cydD 7145809 cydD Escherichia coli 55989 cysteine/glutathione ABC transporter membrane/ATP-binding protein YP_002402027.1 990547 R 585055 CDS YP_002402028.1 218694361 7145810 complement(992436..993401) 1 NC_011748.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase 993401 trxB 7145810 trxB Escherichia coli 55989 thioredoxin reductase YP_002402028.1 992436 R 585055 CDS YP_002402029.1 218694362 7147863 993946..994440 1 NC_011748.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 994440 lrp 7147863 lrp Escherichia coli 55989 leucine-responsive transcriptional regulator YP_002402029.1 993946 D 585055 CDS YP_002402030.1 218694363 7146744 994575..998642 1 NC_011748.1 DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 998642 ftsK 7146744 ftsK Escherichia coli 55989 DNA translocase FtsK YP_002402030.1 994575 D 585055 CDS YP_002402031.1 218694364 7146215 998794..999408 1 NC_011748.1 participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 999408 lolA 7146215 lolA Escherichia coli 55989 outer-membrane lipoprotein carrier protein YP_002402031.1 998794 D 585055 CDS YP_002402032.1 218694365 7146715 999419..1000762 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7567469, 7628437, 11459952, 11029431; Product type cp : cell process; recombination factor protein RarA 1000762 ycaJ 7146715 ycaJ Escherichia coli 55989 recombination factor protein RarA YP_002402032.1 999419 D 585055 CDS YP_002402033.1 218694366 7148243 1000853..1002145 1 NC_011748.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1002145 serS 7148243 serS Escherichia coli 55989 seryl-tRNA synthetase YP_002402033.1 1000853 D 585055 CDS YP_002402034.1 218694367 7147635 1002384..1004828 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 94171715, 10801884, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit A 1004828 dmsA 7147635 dmsA Escherichia coli 55989 dimethyl sulfoxide reductase, anaerobic subunit A YP_002402034.1 1002384 D 585055 CDS YP_002402035.1 218694368 7145928 1004839..1005456 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91070067, 91355180, 92011349, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit B 1005456 dmsB 7145928 dmsB Escherichia coli 55989 dimethyl sulfoxide reductase, anaerobic subunit B YP_002402035.1 1004839 D 585055 CDS YP_002402036.1 218694369 7145929 1005458..1006321 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 3062312, 8429002; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit C 1006321 dmsC 7145929 dmsC Escherichia coli 55989 dimethyl sulfoxide reductase, anaerobic subunit C YP_002402036.1 1005458 D 585055 CDS YP_002402037.1 218694370 7145930 complement(1006357..1006983) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9782055, 3062312, 11714269; Product type pe : enzyme; hydrolase 1006983 ycaC 7145930 ycaC Escherichia coli 55989 hydrolase YP_002402037.1 1006357 R 585055 CDS YP_002402038.1 218694371 7148240 1007297..1008445 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; MFS family transporter protein 1008445 ycaD 7148240 ycaD Escherichia coli 55989 MFS family transporter protein YP_002402038.1 1007297 D 585055 CDS YP_002402039.1 218694372 7148241 1008655..1010085 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pt : transporter; transporter 1010085 ycaM 7148241 ycaM Escherichia coli 55989 transporter YP_002402039.1 1008655 D 585055 CDS YP_002402040.1 218694373 7148246 complement(1010086..1010994) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1010994 ycaN 7148246 ycaN Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402040.1 1010086 R 585055 CDS YP_002402041.1 218694374 7148247 1011094..1011684 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3053170; Product type pe : enzyme; hypothetical protein 1011684 ycaK 7148247 ycaK Escherichia coli 55989 hypothetical protein YP_002402041.1 1011094 D 585055 CDS YP_002402042.1 218694375 7148244 complement(1011766..1012506) 1 NC_011748.1 activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 1012506 pflA 7148244 pflA Escherichia coli 55989 pyruvate formate lyase-activating enzyme 1 YP_002402042.1 1011766 R 585055 CDS YP_002402043.1 218694376 7147141 complement(1012698..1014980) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91064082, 92276323, 10504733, 1310545, 2651404, 3053170, 9629924; Product type e : enzyme; pyruvate formate lyase I 1014980 pflB 7147141 pflB Escherichia coli 55989 pyruvate formate lyase I YP_002402043.1 1012698 R 585055 CDS YP_002402044.1 218694377 7147142 complement(1015035..1015892) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293770, 2651404; Product type t : transporter; formate transporter 1015892 focA 7147142 focA Escherichia coli 55989 formate transporter YP_002402044.1 1015035 R 585055 CDS YP_002402045.1 218694378 7146166 complement(1016297..1018057) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1018057 ycaO 7146166 ycaO Escherichia coli 55989 hypothetical protein YP_002402045.1 1016297 R 585055 CDS YP_002402046.1 218694379 7148248 1018187..1018879 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1018879 ycaP 7148248 ycaP Escherichia coli 55989 inner membrane protein YP_002402046.1 1018187 D 585055 CDS YP_002402047.1 218694380 7148249 1019078..1020166 1 NC_011748.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1020166 serC 7148249 serC Escherichia coli 55989 phosphoserine aminotransferase YP_002402047.1 1019078 D 585055 CDS YP_002402048.1 218694381 7147634 1020237..1021520 1 NC_011748.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1021520 aroA 7147634 aroA Escherichia coli 55989 3-phosphoshikimate 1-carboxyvinyltransferase YP_002402048.1 1020237 D 585055 CDS YP_002402049.1 218694382 7145539 1021689..1022453 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; lipoprotein with metallohydrolase domain 1022453 ycaL 7145539 ycaL Escherichia coli 55989 lipoprotein with metallohydrolase domain YP_002402049.1 1021689 D 585055 CDS YP_002402050.1 218694383 7148245 1022626..1023309 1 NC_011748.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1023309 cmk 7148245 cmk Escherichia coli 55989 cytidylate kinase YP_002402050.1 1022626 D 585055 CDS YP_002402051.1 218694384 7145728 1023420..1025093 1 NC_011748.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1025093 rpsA 7145728 rpsA Escherichia coli 55989 30S ribosomal protein S1 YP_002402051.1 1023420 D 585055 CDS YP_002402052.1 218694385 7147505 1025253..1025537 1 NC_011748.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 1025537 ihfB 7147505 ihfB Escherichia coli 55989 integration host factor subunit beta YP_002402052.1 1025253 D 585055 CDS YP_002402053.1 218694386 7146547 1025744..1028008 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 1028008 ycaI 7146547 ycaI Escherichia coli 55989 hypothetical protein YP_002402053.1 1025744 D 585055 CDS YP_002402054.1 218694387 7148242 1028045..1029793 1 NC_011748.1 involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 1029793 msbA 7148242 msbA Escherichia coli 55989 lipid transporter ATP-binding/permease YP_002402054.1 1028045 D 585055 CDS YP_002402055.1 218694388 7146906 1029790..1030776 1 NC_011748.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 1030776 lpxK 7146906 lpxK Escherichia coli 55989 tetraacyldisaccharide 4'-kinase YP_002402055.1 1029790 D 585055 CDS YP_002402056.1 218694389 7146740 1030813..1032045 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1032045 ycaQ 7146740 ycaQ Escherichia coli 55989 hypothetical protein YP_002402056.1 1030813 D 585055 CDS YP_002402057.1 218694390 7148250 1032097..1032279 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1032279 ycaR 7148250 ycaR Escherichia coli 55989 hypothetical protein YP_002402057.1 1032097 D 585055 CDS YP_002402058.1 218694391 7148251 1032276..1033022 1 NC_011748.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1033022 kdsB 7148251 kdsB Escherichia coli 55989 3-deoxy-manno-octulosonate cytidylyltransferase YP_002402058.1 1032276 D 585055 CDS YP_002402059.1 218694392 7146660 1033176..1034069 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1034069 ycbJ 7146660 ycbJ Escherichia coli 55989 hypothetical protein YP_002402059.1 1033176 D 585055 CDS YP_002402060.1 218694393 7148256 complement(1034046..1034825) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 1034825 ycbC 7148256 ycbC Escherichia coli 55989 hypothetical protein YP_002402060.1 1034046 R 585055 CDS YP_002402061.1 218694394 7148253 complement(1034728..1034892) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1034892 7148253 EC55989_0966 Escherichia coli 55989 hypothetical protein YP_002402061.1 1034728 R 585055 CDS YP_002402062.1 218694395 7144482 1034961..1035746 1 NC_011748.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; metallothionein SmtA 1035746 smtA 7144482 smtA Escherichia coli 55989 metallothionein SmtA YP_002402062.1 1034961 D 585055 CDS YP_002402063.1 218694396 7147670 1035743..1037065 1 NC_011748.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 1037065 mukF 7147670 mukF Escherichia coli 55989 condesin subunit F YP_002402063.1 1035743 D 585055 CDS YP_002402064.1 218694397 7146920 1037073..1037750 1 NC_011748.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 1037750 mukE 7146920 mukE Escherichia coli 55989 condesin subunit E YP_002402064.1 1037073 D 585055 CDS YP_002402065.1 218694398 7146919 1037750..1042210 1 NC_011748.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 1042210 mukB 7146919 mukB Escherichia coli 55989 cell division protein MukB YP_002402065.1 1037750 D 585055 CDS YP_002402066.1 218694399 7146918 1042471..1044318 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 1044318 ycbB 7146918 ycbB Escherichia coli 55989 hypothetical protein YP_002402066.1 1042471 D 585055 CDS YP_002402067.1 218694400 7148252 1044499..1045047 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1045047 ycbK 7148252 ycbK Escherichia coli 55989 hypothetical protein YP_002402067.1 1044499 D 585055 CDS YP_002402068.1 218694401 7148257 1045074..1045721 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14529289; Product type pe : enzyme; metal-binding hydrolase 1045721 ycbL 7148257 ycbL Escherichia coli 55989 metal-binding hydrolase YP_002402068.1 1045074 D 585055 CDS YP_002402069.1 218694402 7148258 complement(1045963..1046943) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 1046943 7148258 EC55989_0975 Escherichia coli 55989 transposase, IS110 family YP_002402069.1 1045963 R 585055 CDS YP_002402070.1 218694403 7144483 complement(1047222..1048412) 1 NC_011748.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 1048412 aspC 7144483 aspC Escherichia coli 55989 aromatic amino acid aminotransferase YP_002402070.1 1047222 R 585055 CDS YP_002402071.1 218694404 7145572 complement(1048597..1049685) 1 NC_011748.1 outer membrane porin F; 1a; Ia; b; outer membrane protein F 1049685 ompF 7145572 ompF Escherichia coli 55989 outer membrane protein F YP_002402071.1 1048597 R 585055 CDS YP_002402072.1 218694405 7147067 complement(1050287..1051687) 1 NC_011748.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase 1051687 asnC 7147067 asnC Escherichia coli 55989 asparaginyl-tRNA synthetase YP_002402072.1 1050287 R 585055 CDS YP_002402073.1 218694406 7145570 complement(1051856..1053058) 1 NC_011748.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase 1053058 pncB 7145570 pncB Escherichia coli 55989 nicotinate phosphoribosyltransferase YP_002402073.1 1051856 R 585055 CDS YP_002402074.1 218694407 7147202 1053324..1055936 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101837, 86164315, 87163509, 2436977, 3018440; Product type e : enzyme; aminopeptidase 1055936 pepN 7147202 pepN Escherichia coli 55989 aminopeptidase YP_002402074.1 1053324 D 585055 CDS YP_002402075.1 218694408 7147134 complement(1056143..1056910) 1 NC_011748.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit 1056910 ssuB 7147134 ssuB Escherichia coli 55989 aliphatic sulfonates transport ATP-binding subunit YP_002402075.1 1056143 R 585055 CDS YP_002402076.1 218694409 7147720 complement(1056907..1057698) 1 NC_011748.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease 1057698 ssuC 7147720 ssuC Escherichia coli 55989 alkanesulfonate transporter permease YP_002402076.1 1056907 R 585055 CDS YP_002402077.1 218694410 7147721 complement(1057709..1058854) 1 NC_011748.1 catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase 1058854 ssuD 7147721 ssuD Escherichia coli 55989 alkanesulfonate monooxygenase YP_002402077.1 1057709 R 585055 CDS YP_002402078.1 218694411 7147722 complement(1058851..1059810) 1 NC_011748.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit 1059810 ssuA 7147722 ssuA Escherichia coli 55989 alkanesulfonate transporter substrate-binding subunit YP_002402078.1 1058851 R 585055 CDS YP_002402079.1 218694412 7147719 complement(1059803..1060378) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20245523, 99410391, 99436146, 8774726; Product type e : enzyme; NAD(P)H-dependent FMN reductase 1060378 ssuE 7147719 ssuE Escherichia coli 55989 NAD(P)H-dependent FMN reductase YP_002402079.1 1059803 R 585055 CDS YP_002402080.1 218694413 7147723 1060725..1061276 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type ps : structure; fimbrial-like adhesin protein 1061276 ycbQ 7147723 ycbQ Escherichia coli 55989 fimbrial-like adhesin protein YP_002402080.1 1060725 D 585055 CDS YP_002402081.1 218694414 7148259 1061359..1062060 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; periplasmic pilin chaperone 1062060 ycbR 7148259 ycbR Escherichia coli 55989 periplasmic pilin chaperone YP_002402081.1 1061359 D 585055 CDS YP_002402082.1 218694415 7148260 1062085..1064685 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; outer membrane export usher protein 1064685 ycbS 7148260 ycbS Escherichia coli 55989 outer membrane export usher protein YP_002402082.1 1062085 D 585055 CDS YP_002402083.1 218694416 7148261 1064676..1065746 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7721701; Product type ps : structure; fimbrial-like adhesin protein 1065746 ycbT 7148261 ycbT Escherichia coli 55989 fimbrial-like adhesin protein YP_002402083.1 1064676 D 585055 CDS YP_002402084.1 218694417 7148262 1065758..1066300 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 1066300 ycbU 7148262 ycbU Escherichia coli 55989 fimbrial-like adhesin protein YP_002402084.1 1065758 D 585055 CDS YP_002402085.1 218694418 7148263 1066308..1066823 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 1066823 ycbV 7148263 ycbV Escherichia coli 55989 fimbrial-like adhesin protein YP_002402085.1 1066308 D 585055 CDS YP_002402086.1 218694419 7148264 1066816..1067526 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; pili assembly chaperone 1067526 ycbF 7148264 ycbF Escherichia coli 55989 pili assembly chaperone YP_002402086.1 1066816 D 585055 CDS YP_002402087.1 218694420 7148254 1067637..1068647 1 NC_011748.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1068647 pyrD 7148254 pyrD Escherichia coli 55989 dihydroorotate dehydrogenase 2 YP_002402087.1 1067637 D 585055 CDS YP_002402088.1 218694421 7147319 1068821..1069363 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1069363 ycbW 7147319 ycbW Escherichia coli 55989 hypothetical protein YP_002402088.1 1068821 D 585055 CDS YP_002402089.1 218694422 7148265 complement(1069360..1070469) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1327782; Product type pe : enzyme; 2Fe-2S cluster-containing protein 1070469 ycbX 7148265 ycbX Escherichia coli 55989 2Fe-2S cluster-containing protein YP_002402089.1 1069360 R 585055 CDS YP_002402090.1 218694423 7148266 1070713..1072821 1 NC_011748.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1072821 rlmL 7148266 rlmL Escherichia coli 55989 23S rRNA m(2)G2445 methyltransferase YP_002402090.1 1070713 D 585055 CDS YP_002402091.1 218694424 7148267 1072832..1074739 1 NC_011748.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 1074739 uup 7148267 uup Escherichia coli 55989 ABC transporter ATPase YP_002402091.1 1072832 D 585055 CDS YP_002402092.1 218694425 7147932 1074869..1076122 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible membrane protein A 1076122 pqiA 7147932 pqiA Escherichia coli 55989 paraquat-inducible membrane protein A YP_002402092.1 1074869 D 585055 CDS YP_002402093.1 218694426 7147236 1076127..1077767 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible protein B 1077767 pqiB 7147236 pqiB Escherichia coli 55989 paraquat-inducible protein B YP_002402093.1 1076127 D 585055 CDS YP_002402094.1 218694427 7147237 1077779..1078327 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1078327 ymbA 7147237 ymbA Escherichia coli 55989 hypothetical protein YP_002402094.1 1077779 D 585055 CDS YP_002402095.1 218694428 7149263 1078583..1078750 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1101029, 90207255, 2832401, 8440252; Product type f : factor; ribosome modulation factor 1078750 rmf 7149263 rmf Escherichia coli 55989 ribosome modulation factor YP_002402095.1 1078583 D 585055 CDS YP_002402096.1 218694429 7147430 complement(1078820..1079338) 1 NC_011748.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase 1079338 fabA 7147430 fabA Escherichia coli 55989 3-hydroxydecanoyl-ACP dehydratase YP_002402096.1 1078820 R 585055 CDS YP_002402097.1 218694430 7146046 complement(1079407..1081167) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; ATP-dependent protease 1081167 ycbZ 7146046 ycbZ Escherichia coli 55989 ATP-dependent protease YP_002402097.1 1079407 R 585055 CDS YP_002402098.1 218694431 7148268 1081353..1081805 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1081805 ycbG 7148268 ycbG Escherichia coli 55989 hypothetical protein YP_002402098.1 1081353 D 585055 CDS YP_002402099.1 218694432 7148255 complement(1081881..1082921) 1 NC_011748.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A 1082921 ompA 7148255 ompA Escherichia coli 55989 outer membrane protein A YP_002402099.1 1081881 R 585055 CDS YP_002402100.1 218694433 7146624 complement(1083278..1083787) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10368140, 91072263, 93163041, 98348458, 3297925, 6253901, 6306396; Product type cp : cell process; SOS cell division inhibitor 1083787 sulA 7146624 sulA Escherichia coli 55989 SOS cell division inhibitor YP_002402100.1 1083278 R 585055 CDS YP_002402101.1 218694434 7147739 1084006..1084635 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1084635 yccR 7147739 yccR Escherichia coli 55989 hypothetical protein YP_002402101.1 1084006 D 585055 CDS YP_002402102.1 218694435 7148275 complement(1084598..1086751) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1086751 yccS 7148275 yccS Escherichia coli 55989 inner membrane protein YP_002402102.1 1084598 R 585055 CDS YP_002402103.1 218694436 7148276 complement(1086770..1087216) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 1087216 yccF 7148276 yccF Escherichia coli 55989 hypothetical protein YP_002402103.1 1086770 R 585055 CDS YP_002402104.1 218694437 7148272 1087339..1089393 1 NC_011748.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1089393 helD 7148272 helD Escherichia coli 55989 DNA helicase IV YP_002402104.1 1087339 D 585055 CDS YP_002402105.1 218694438 7146406 complement(1089425..1089883) 1 NC_011748.1 catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase 1089883 mgsA 7146406 mgsA Escherichia coli 55989 methylglyoxal synthase YP_002402105.1 1089425 R 585055 CDS YP_002402106.1 218694439 7146842 complement(1089979..1090641) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1090641 yccT 7146842 yccT Escherichia coli 55989 hypothetical protein YP_002402106.1 1089979 R 585055 CDS YP_002402107.1 218694440 7148277 1090814..1091227 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; CoA-binding protein 1091227 yccU 7148277 yccU Escherichia coli 55989 CoA-binding protein YP_002402107.1 1090814 D 585055 CDS YP_002402108.1 218694441 7148278 complement(1091272..1091589) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700277, 15569148; Product type f : factor; heat shock protein HspQ 1091589 yccV 7148278 yccV Escherichia coli 55989 heat shock protein HspQ YP_002402108.1 1091272 R 585055 CDS YP_002402109.1 218694442 7148279 complement(1091647..1092750) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; AdoMet-dependent methyltransferase, UPF0064 family 1092750 yccW 7148279 yccW Escherichia coli 55989 AdoMet-dependent methyltransferase, UPF0064 family YP_002402109.1 1091647 R 585055 CDS YP_002402110.1 218694443 7148280 1092719..1093210 1 NC_011748.1 catalyzes the hydrolysis of acylphosphate; acylphosphatase 1093210 yccX 7148280 yccX Escherichia coli 55989 acylphosphatase YP_002402110.1 1092719 D 585055 CDS YP_002402111.1 218694444 7148281 complement(1093207..1093536) 1 NC_011748.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE 1093536 tusE 7148281 tusE Escherichia coli 55989 sulfur transfer protein TusE YP_002402111.1 1093207 R 585055 CDS YP_002402112.1 218694445 7147879 complement(1093627..1094286) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6376117; Product type m : membrane component; hypothetical protein 1094286 yccA 7147879 yccA Escherichia coli 55989 hypothetical protein YP_002402112.1 1093627 R 585055 CDS YP_002402113.1 218694446 7148269 1094492..1094704 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1094704 7148269 EC55989_1020 Escherichia coli 55989 hypothetical protein YP_002402113.1 1094492 D 585055 CDS YP_002402114.1 218694447 7144484 complement(1094694..1095713) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; integrase from prophage 1095713 7144484 EC55989_1021 Escherichia coli 55989 integrase from prophage YP_002402114.1 1094694 R 585055 CDS YP_002402115.1 218694448 7144485 complement(1095691..1096071) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 1096071 7144485 EC55989_1022 Escherichia coli 55989 hypothetical protein YP_002402115.1 1095691 R 585055 CDS YP_002402116.1 218694449 7144486 complement(1096001..1098493) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; exonuclease from phage origin 1098493 7144486 EC55989_1023 Escherichia coli 55989 exonuclease from phage origin YP_002402116.1 1096001 R 585055 CDS YP_002402117.1 218694450 7144487 complement(1098589..1098777) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1098777 7144487 EC55989_1024 Escherichia coli 55989 hypothetical protein YP_002402117.1 1098589 R 585055 CDS YP_002402118.1 218694451 7144488 complement(1098774..1099067) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; regulator of cell division encoded by prophage 1099067 7144488 EC55989_1025 Escherichia coli 55989 regulator of cell division encoded by prophage YP_002402118.1 1098774 R 585055 CDS YP_002402119.1 218694452 7145911 complement(1099530..1099748) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage 1099748 ydfC 7145911 ydfC Escherichia coli 55989 Qin prophage YP_002402119.1 1099530 R 585055 CDS YP_002402120.1 218694453 7148431 complement(1099778..1099906) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage 1099906 ydfB 7148431 ydfB Escherichia coli 55989 Qin prophage YP_002402120.1 1099778 R 585055 CDS YP_002402121.1 218694454 7148430 complement(1099908..1100063) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage 1100063 ydfA 7148430 ydfA Escherichia coli 55989 Qin prophage YP_002402121.1 1099908 R 585055 CDS YP_002402122.1 218694455 7148428 complement(1100271..1100678) 1 NC_011748.1 The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown.; transcriptional repressor DicA 1100678 dicA 7148428 dicA Escherichia coli 55989 transcriptional repressor DicA YP_002402122.1 1100271 R 585055 CDS YP_002402123.1 218694456 7145906 1100755..1100982 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88232418, 3532030; Product type h : extrachromosomal origin; DNA-binding transcriptional regulator DicC 1100982 dicC 7145906 dicC Escherichia coli 55989 DNA-binding transcriptional regulator DicC YP_002402123.1 1100755 D 585055 CDS YP_002402124.1 218694457 7145909 1100966..1101517 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1101517 7145909 EC55989_1031 Escherichia coli 55989 hypothetical protein YP_002402124.1 1100966 D 585055 CDS YP_002402125.1 218694458 7144490 1101414..1102529 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1102529 7144490 EC55989_1032 Escherichia coli 55989 hypothetical protein YP_002402125.1 1101414 D 585055 CDS YP_002402126.1 218694459 7144491 1102318..1102983 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; replication protein in prophage 1102983 7144491 EC55989_1033 Escherichia coli 55989 replication protein in prophage YP_002402126.1 1102318 D 585055 CDS YP_002402127.1 218694460 7144492 1102999..1103787 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1103787 7144492 EC55989_1034 Escherichia coli 55989 hypothetical protein YP_002402127.1 1102999 D 585055 CDS YP_002402128.1 218694461 7144493 1103788..1104225 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1104225 7144493 EC55989_1035 Escherichia coli 55989 phage protein YP_002402128.1 1103788 D 585055 CDS YP_002402129.1 218694462 7144494 1104222..1104710 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; methyltransferase 1104710 7144494 EC55989_1036 Escherichia coli 55989 methyltransferase YP_002402129.1 1104222 D 585055 CDS YP_002402130.1 218694463 7144495 1104703..1104957 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 1104957 7144495 EC55989_1037 Escherichia coli 55989 hypothetical protein YP_002402130.1 1104703 D 585055 CDS YP_002402131.1 218694464 7144496 1104950..1105261 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1105261 7144496 EC55989_1038 Escherichia coli 55989 hypothetical protein YP_002402131.1 1104950 D 585055 CDS YP_002402132.1 218694465 7144497 1105390..1105572 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1105572 7144497 EC55989_1039 Escherichia coli 55989 hypothetical protein YP_002402132.1 1105390 D 585055 CDS YP_002402133.1 218694466 7144498 1105565..1105741 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1105741 7144498 EC55989_1040 Escherichia coli 55989 hypothetical protein YP_002402133.1 1105565 D 585055 CDS YP_002402134.1 218694467 7144499 1105738..1106253 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; prophage protein 1106253 7144499 EC55989_1041 Escherichia coli 55989 prophage protein YP_002402134.1 1105738 D 585055 CDS YP_002402135.1 218694468 7144500 complement(1106485..1106988) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 1106988 insB 7144500 insB Escherichia coli 55989 IS1 transposase InsAB' YP_002402135.1 1106485 R 585055 CDS YP_002402136.1 218694469 7146583 complement(1106907..1107182) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 1107182 insA 7146583 insA Escherichia coli 55989 IS1 repressor protein InsA YP_002402136.1 1106907 R 585055 CDS YP_002402137.1 218694470 7146571 1107961..1108212 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2990907; Product type h : extrachromosomal origin; Qin prophage 1108212 rem 7146571 rem Escherichia coli 55989 Qin prophage YP_002402137.1 1107961 D 585055 CDS YP_002402138.1 218694471 7147370 1108559..1109614 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1109614 ydfU 7147370 ydfU Escherichia coli 55989 phage protein YP_002402138.1 1108559 D 585055 CDS YP_002402139.1 218694472 7148442 1109615..1109995 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; Holliday juction resolvase 1109995 7148442 EC55989_1046 Escherichia coli 55989 Holliday juction resolvase YP_002402139.1 1109615 D 585055 CDS YP_002402140.1 218694473 7144501 1109992..1110813 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; antitermination protein Q of prophage 1110813 7144501 EC55989_1047 Escherichia coli 55989 antitermination protein Q of prophage YP_002402140.1 1109992 D 585055 CDS YP_002402141.1 218694474 7144502 1110953..1111237 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1111237 7144502 EC55989_1048 Escherichia coli 55989 hypothetical protein YP_002402141.1 1110953 D 585055 CDS YP_002402142.1 218694475 7144503 1111388..1112437 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; DNA adenine methyltransferase ( DNA methylase) from phage origin 1112437 7144503 EC55989_1049 Escherichia coli 55989 DNA adenine methyltransferase ( DNA methylase) from phage origin YP_002402142.1 1111388 D 585055 CDS YP_002402143.1 218694476 7145325 1113226..1115088 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1115088 7145325 EC55989_1050 Escherichia coli 55989 phage protein YP_002402143.1 1113226 D 585055 CDS YP_002402144.1 218694477 7144505 1115133..1115453 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Lysis protein S homolog from lambdoid prophage 1115453 7144505 EC55989_1051 Escherichia coli 55989 Lysis protein S homolog from lambdoid prophage YP_002402144.1 1115133 D 585055 CDS YP_002402145.1 218694478 7144506 1115458..1116264 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1116264 7144506 EC55989_1052 Escherichia coli 55989 phage protein YP_002402145.1 1115458 D 585055 CDS YP_002402146.1 218694479 7144507 complement(1116274..1116588) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1116588 7144507 EC55989_1053 Escherichia coli 55989 hypothetical protein YP_002402146.1 1116274 R 585055 CDS YP_002402147.1 218694480 7144508 1116717..1117250 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane-associated lysozyme; Qin prophage 1117250 ydfQ 7144508 ydfQ Escherichia coli 55989 membrane-associated lysozyme; Qin prophage YP_002402147.1 1116717 D 585055 CDS YP_002402148.1 218694481 7148439 1117328..1117540 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; prophage protein 1117540 7148439 EC55989_1055 Escherichia coli 55989 prophage protein YP_002402148.1 1117328 D 585055 CDS YP_002402149.1 218694482 7144509 1117521..1117793 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1117793 7144509 EC55989_1056 Escherichia coli 55989 hypothetical protein YP_002402149.1 1117521 D 585055 CDS YP_002402150.1 218694483 7144510 1117809..1118360 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein) from bacteriophage origin 1118360 rz 7144510 rz Escherichia coli 55989 Endopeptidase (Lysis protein) from bacteriophage origin YP_002402150.1 1117809 D 585055 CDS YP_002402151.1 218694484 7147596 1118813..1119289 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; phage protein 1119289 7147596 EC55989_1059 Escherichia coli 55989 phage protein YP_002402151.1 1118813 D 585055 CDS YP_002402152.1 218694485 7144511 1119286..1121409 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage terminase large subunit 1121409 7144511 EC55989_1060 Escherichia coli 55989 phage terminase large subunit YP_002402152.1 1119286 D 585055 CDS YP_002402153.1 218694486 7144512 1121382..1121618 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1121618 7144512 EC55989_1061 Escherichia coli 55989 phage protein YP_002402153.1 1121382 D 585055 CDS YP_002402154.1 218694487 7144513 1121618..1123120 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; head-tail preconnector protein 1123120 7144513 EC55989_1062 Escherichia coli 55989 head-tail preconnector protein YP_002402154.1 1121618 D 585055 CDS YP_002402155.1 218694488 7144514 1122918..1125089 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; ATP-dependent Clp protease proteolytic subunit (Endopeptidase Clp) of prophage 1125089 clp 7144514 clp Escherichia coli 55989 ATP-dependent Clp protease proteolytic subunit (Endopeptidase Clp) of prophage YP_002402155.1 1122918 D 585055 CDS YP_002402156.1 218694489 7145721 1125177..1125503 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical membrane protein from phage origin 1125503 7145721 EC55989_1064 Escherichia coli 55989 hypothetical membrane protein from phage origin YP_002402156.1 1125177 D 585055 CDS YP_002402157.1 218694490 7144515 1125496..1125777 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1125777 7144515 EC55989_1065 Escherichia coli 55989 phage protein YP_002402157.1 1125496 D 585055 CDS YP_002402158.1 218694491 7144516 1125774..1126403 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein Z 1126403 Z 7144516 Z Escherichia coli 55989 Minor tail protein Z YP_002402158.1 1125774 D 585055 CDS YP_002402159.1 218694492 7149486 1126416..1126814 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein U 1126814 U 7149486 U Escherichia coli 55989 Minor tail protein U YP_002402159.1 1126416 D 585055 CDS YP_002402160.1 218694493 7147886 1126822..1127568 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail protein V 1127568 7147886 EC55989_1068 Escherichia coli 55989 Major tail protein V YP_002402160.1 1126822 D 585055 CDS YP_002402161.1 218694494 7144517 1127587..1128018 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein G 1128018 7144517 EC55989_1069 Escherichia coli 55989 Minor tail protein G YP_002402161.1 1127587 D 585055 CDS YP_002402162.1 218694495 7144518 1128045..1128449 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein T 1128449 T 7144518 T Escherichia coli 55989 Minor tail protein T YP_002402162.1 1128045 D 585055 CDS YP_002402163.1 218694496 7147743 1128430..1131042 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein precursor H 1131042 7147743 EC55989_1071 Escherichia coli 55989 Minor tail protein precursor H YP_002402163.1 1128430 D 585055 CDS YP_002402164.1 218694497 7144519 1131039..1131371 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein M 1131371 7144519 EC55989_1072 Escherichia coli 55989 Minor tail protein M YP_002402164.1 1131039 D 585055 CDS YP_002402165.1 218694498 7144520 1131371..1132069 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein L 1132069 7144520 EC55989_1073 Escherichia coli 55989 Minor tail protein L YP_002402165.1 1131371 D 585055 CDS YP_002402166.1 218694499 7144521 1132032..1132817 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber component K of prophage 1132817 7144521 EC55989_1074 Escherichia coli 55989 tail fiber component K of prophage YP_002402166.1 1132032 D 585055 CDS YP_002402167.1 218694500 7144522 1132715..1133386 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail assembly protein I 1133386 7144522 EC55989_1075 Escherichia coli 55989 Tail assembly protein I YP_002402167.1 1132715 D 585055 CDS YP_002402168.1 218694501 7144523 1133447..1136842 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J 1136842 7144523 EC55989_1076 Escherichia coli 55989 Host specificity protein J YP_002402168.1 1133447 D 585055 CDS YP_002402169.1 218694502 7144524 1136910..1137509 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; Lom-like outer membrane protein of prophage 1137509 7144524 EC55989_1077 Escherichia coli 55989 Lom-like outer membrane protein of prophage YP_002402169.1 1136910 D 585055 CDS YP_002402170.1 218694503 7144525 1137661..1139064 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber protein (modular protein) 1139064 7144525 EC55989_1078 Escherichia coli 55989 tail fiber protein (modular protein) YP_002402170.1 1137661 D 585055 CDS YP_002402171.1 218694504 7144526 1138986..1139681 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1139681 7144526 EC55989_1079 Escherichia coli 55989 hypothetical protein YP_002402171.1 1138986 D 585055 CDS YP_002402172.1 218694505 7145401 1140806..1141924 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86192450, 90202716, 92215587; Product type e : enzyme; hydrogenase 1, small subunit 1141924 hyaA 7145401 hyaA Escherichia coli 55989 hydrogenase 1, small subunit YP_002402172.1 1140806 D 585055 CDS YP_002402173.1 218694506 7146482 1141921..1143714 1 NC_011748.1 involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1143714 hyaB 7146482 hyaB Escherichia coli 55989 hydrogenase 1 large subunit YP_002402173.1 1141921 D 585055 CDS YP_002402174.1 218694507 7146483 1143733..1144440 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type c : carrier; hydrogenase 1 b-type cytochrome subunit 1144440 hyaC 7146483 hyaC Escherichia coli 55989 hydrogenase 1 b-type cytochrome subunit YP_002402174.1 1143733 D 585055 CDS YP_002402175.1 218694508 7146484 1144437..1145024 1 NC_011748.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1145024 hyaD 7146484 hyaD Escherichia coli 55989 hydrogenase 1 maturation protease YP_002402175.1 1144437 D 585055 CDS YP_002402176.1 218694509 7146485 1145021..1145419 1 NC_011748.1 involved in processing hydrogenase proteins HyaA and HyaB; hydrogenase-1 operon protein HyaE 1145419 hyaE 7146485 hyaE Escherichia coli 55989 hydrogenase-1 operon protein HyaE YP_002402176.1 1145021 D 585055 CDS YP_002402177.1 218694510 7146486 1145416..1146273 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type f : factor; protein involved in nickel incorporation into hydrogenase-1 proteins 1146273 hyaF 7146486 hyaF Escherichia coli 55989 protein involved in nickel incorporation into hydrogenase-1 proteins YP_002402177.1 1145416 D 585055 CDS YP_002402178.1 218694511 7146487 1146407..1147951 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit I 1147951 appC 7146487 appC Escherichia coli 55989 cytochrome bd-II oxidase subunit I YP_002402178.1 1146407 D 585055 CDS YP_002402179.1 218694512 7145510 1147963..1149099 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit II 1149099 appB 7145510 appB Escherichia coli 55989 cytochrome bd-II oxidase subunit II YP_002402179.1 1147963 D 585055 CDS YP_002402180.1 218694513 7145509 1149284..1150582 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20122624, 92049231, 93054596, 10696472, 2168385, 3038201, 8387749; Product type e : enzyme; phosphoanhydride phosphorylase 1150582 appA 7145509 appA Escherichia coli 55989 phosphoanhydride phosphorylase YP_002402180.1 1149284 D 585055 CDS YP_002402181.1 218694514 7145508 complement(1150697..1152877) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10369665, 11090276, 2168385, 7984428; Product type e : enzyme; cryptic autophosphorylating protein tyrosine kinase Etk 1152877 yccC 7145508 yccC Escherichia coli 55989 cryptic autophosphorylating protein tyrosine kinase Etk YP_002402181.1 1150697 R 585055 CDS YP_002402182.1 218694515 7148270 complement(1152897..1153343) 1 NC_011748.1 Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase 1153343 etp 7148270 etp Escherichia coli 55989 phosphotyrosine-protein phosphatase YP_002402182.1 1152897 R 585055 CDS YP_002402183.1 218694516 7146025 complement(1153331..1154470) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8759852; Product type pt : transporter; exopolysaccharide export protein 1154470 yccZ 7146025 yccZ Escherichia coli 55989 exopolysaccharide export protein YP_002402183.1 1153331 R 585055 CDS YP_002402184.1 218694517 7148282 complement(1154516..1156612) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1156612 ymcA 7148282 ymcA Escherichia coli 55989 hypothetical protein YP_002402184.1 1154516 R 585055 CDS YP_002402185.1 218694518 7149264 complement(1156612..1157358) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1157358 ymcB 7149264 ymcB Escherichia coli 55989 hypothetical protein YP_002402185.1 1156612 R 585055 CDS YP_002402186.1 218694519 7149265 complement(1157355..1157999) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; outer membrane lipoprotein 1157999 ymcC 7149265 ymcC Escherichia coli 55989 outer membrane lipoprotein YP_002402186.1 1157355 R 585055 CDS YP_002402187.1 218694520 7149266 complement(1158081..1158353) 1 NC_011748.1 hypothetical protein 1158353 7149266 EC55989_1095 Escherichia coli 55989 hypothetical protein YP_002402187.1 1158081 R 585055 CDS YP_002402188.1 218694521 7144528 complement(1158106..1158411) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; inner membrane protein 1158411 ymcD 7144528 ymcD Escherichia coli 55989 inner membrane protein YP_002402188.1 1158106 R 585055 CDS YP_002402189.1 218694522 7149267 complement(1158853..1159065) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9484881, 9439003; Product type f : factor; stress protein, member of the CspA-family 1159065 cspH 7149267 cspH Escherichia coli 55989 stress protein, member of the CspA-family YP_002402189.1 1158853 R 585055 CDS YP_002402190.1 218694523 7145782 complement(1159124..1159627) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 1159627 insB 7145782 insB Escherichia coli 55989 IS1 transposase InsAB' YP_002402190.1 1159124 R 585055 CDS YP_002402191.1 218694524 7146584 complement(1159546..1159821) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 1159821 insA 7146584 insA Escherichia coli 55989 IS1 repressor protein InsA YP_002402191.1 1159546 R 585055 CDS YP_002402192.1 218694525 7146572 1160128..1160340 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881, 15466053, 8631696, 9439003; Product type r : regulator; cold shock protein CspG 1160340 cspG 7146572 cspG Escherichia coli 55989 cold shock protein CspG YP_002402192.1 1160128 D 585055 CDS YP_002402193.1 218694526 7145781 1160734..1160907 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15317805, 11544213; Product type pr : regulator; regulator of phosphatidylethanolamine synthesis 1160907 gnsA 7145781 gnsA Escherichia coli 55989 regulator of phosphatidylethanolamine synthesis YP_002402193.1 1160734 D 585055 CDS YP_002402194.1 218694527 7146348 complement(1160956..1162029) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; 4Fe-4S binding protein 1162029 yccM 7146348 yccM Escherichia coli 55989 4Fe-4S binding protein YP_002402194.1 1160956 R 585055 CDS YP_002402195.1 218694528 7148274 complement(1162101..1164845) 1 NC_011748.1 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS 1164845 torS 7148274 torS Escherichia coli 55989 hybrid sensory histidine kinase TorS YP_002402195.1 1162101 R 585055 CDS YP_002402196.1 218694529 7147825 1164928..1165956 1 NC_011748.1 periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1165956 torT 7147825 torT Escherichia coli 55989 TMAO reductase system periplasmic protein TorT YP_002402196.1 1164928 D 585055 CDS YP_002402197.1 218694530 7147826 complement(1165929..1166621) 1 NC_011748.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR 1166621 torR 7147826 torR Escherichia coli 55989 DNA-binding transcriptional regulator TorR YP_002402197.1 1165929 R 585055 CDS YP_002402198.1 218694531 7147824 1166751..1167923 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293785, 94314186, 99340208, 11056172, 11562502; Product type c : carrier; trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit 1167923 torC 7147824 torC Escherichia coli 55989 trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit YP_002402198.1 1166751 D 585055 CDS YP_002402199.1 218694532 7147821 1167923..1170469 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193091, 90089471, 94293785, 8302830, 8022286; Product type e : enzyme; trimethylamine N-oxide (TMAO) reductase I, catalytic subunit 1170469 torA 7147821 torA Escherichia coli 55989 trimethylamine N-oxide (TMAO) reductase I, catalytic subunit YP_002402199.1 1167923 D 585055 CDS YP_002402200.1 218694533 7147820 1170466..1171065 1 NC_011748.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 1171065 torD 7147820 torD Escherichia coli 55989 chaperone protein TorD YP_002402200.1 1170466 D 585055 CDS YP_002402201.1 218694534 7147822 complement(1171158..1171463) 1 NC_011748.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM 1171463 cbpM 7147822 cbpM Escherichia coli 55989 chaperone-modulator protein CbpM YP_002402201.1 1171158 R 585055 CDS YP_002402202.1 218694535 7145668 complement(1171463..1172383) 1 NC_011748.1 functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA 1172383 cbpA 7145668 cbpA Escherichia coli 55989 curved DNA-binding protein CbpA YP_002402202.1 1171463 R 585055 CDS YP_002402203.1 218694536 7145667 1172716..1173903 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8302830; hypothetical protein 1173903 yccE 7145667 yccE Escherichia coli 55989 hypothetical protein YP_002402203.1 1172716 D 585055 CDS YP_002402204.1 218694537 7148271 1174192..1175433 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12455612, 90368616, 91297199, 2153660, 9298646; Product type e : enzyme; glucose-1-phosphatase/inositol phosphatase 1175433 agp 7148271 agp Escherichia coli 55989 glucose-1-phosphatase/inositol phosphatase YP_002402204.1 1174192 D 585055 CDS YP_002402205.1 218694538 7145473 complement(1175471..1175698) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1175698 yccJ 7145473 yccJ Escherichia coli 55989 hypothetical protein YP_002402205.1 1175471 R 585055 CDS YP_002402206.1 218694539 7148273 complement(1175719..1176315) 1 NC_011748.1 stationary phase protein that binds TrpR repressor; TrpR binding protein WrbA 1176315 wrbA 7148273 wrbA Escherichia coli 55989 TrpR binding protein WrbA YP_002402206.1 1175719 R 585055 CDS YP_002402207.1 218694540 7147973 1176525..1176755 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1176755 7147973 EC55989_1115 Escherichia coli 55989 hypothetical protein YP_002402207.1 1176525 D 585055 CDS YP_002402208.1 218694541 7144529 1176688..1176861 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1176861 ymdF 7144529 ymdF Escherichia coli 55989 hypothetical protein YP_002402208.1 1176688 D 585055 CDS YP_002402209.1 218694542 7149271 complement(1176944..1178272) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type t : transporter; pyrimidine transporter 1178272 rutG 7149271 rutG Escherichia coli 55989 pyrimidine transporter YP_002402209.1 1176944 R 585055 CDS YP_002402210.1 218694543 7147567 complement(1178293..1178787) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542, 10633095; Product type e : enzyme; flavin:NADH oxidoreductase subunit of alternative pyrimidine degradation pathway 1178787 rutF 7147567 rutF Escherichia coli 55989 flavin:NADH oxidoreductase subunit of alternative pyrimidine degradation pathway YP_002402210.1 1178293 R 585055 CDS YP_002402211.1 218694544 7147566 complement(1178798..1179388) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; hypothetical protein 1179388 rutE 7147566 rutE Escherichia coli 55989 hypothetical protein YP_002402211.1 1178798 R 585055 CDS YP_002402212.1 218694545 7147565 complement(1179398..1180198) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway 1180198 rutD 7147565 rutD Escherichia coli 55989 enzyme of the alternative pyrimidine degradation pathway YP_002402212.1 1179398 R 585055 CDS YP_002402213.1 218694546 7147564 complement(1180206..1180592) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway 1180592 rutC 7147564 rutC Escherichia coli 55989 enzyme of the alternative pyrimidine degradation pathway YP_002402213.1 1180206 R 585055 CDS YP_002402214.1 218694547 7147563 complement(1180604..1181296) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway 1181296 rutB 7147563 rutB Escherichia coli 55989 enzyme of the alternative pyrimidine degradation pathway YP_002402214.1 1180604 R 585055 CDS YP_002402215.1 218694548 7147562 complement(1181296..1182444) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; monooxygenase of the alternative pyrimidine degradation pathway 1182444 rutA 7147562 rutA Escherichia coli 55989 monooxygenase of the alternative pyrimidine degradation pathway YP_002402215.1 1181296 R 585055 CDS YP_002402216.1 218694549 7147561 1182675..1183313 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type r : regulator; DNA-binding transcriptional regulator of the alternative pyrimidine degradation pathway 1183313 rutR 7147561 rutR Escherichia coli 55989 DNA-binding transcriptional regulator of the alternative pyrimidine degradation pathway YP_002402216.1 1182675 D 585055 CDS YP_002402217.1 218694550 7147568 complement(1183353..1187315) 1 NC_011748.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase 1187315 putA 7147568 putA Escherichia coli 55989 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase YP_002402217.1 1183353 R 585055 CDS YP_002402218.1 218694551 7147306 1187738..1189246 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12923181, 88213396, 91227628, 93132799, 98359785, 1400239, 1567896, 3053649, 3053687, 3302614, 3325781, 8119910; Product type t : transporter; proline:sodium symporter 1189246 putP 7147306 putP Escherichia coli 55989 proline:sodium symporter YP_002402218.1 1187738 D 585055 CDS YP_002402219.1 218694552 7147307 1189779..1190618 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; ferrous iron permease 1190618 efeU 7147307 efeU Escherichia coli 55989 ferrous iron permease YP_002402219.1 1189779 D 585055 CDS YP_002402220.1 218694553 7145980 1190676..1191803 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 10493123; Product type t : transporter; hypothetical protein 1191803 efeO 7145980 efeO Escherichia coli 55989 hypothetical protein YP_002402220.1 1190676 D 585055 CDS YP_002402221.1 218694554 7145979 1191809..1193080 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 16551627, 15375152; Product type t : transporter; iron transport heme-binding periplasmic protein 1193080 efeB 7145979 efeB Escherichia coli 55989 iron transport heme-binding periplasmic protein YP_002402221.1 1191809 D 585055 CDS YP_002402222.1 218694555 7145978 complement(1193147..1193344) 1 NC_011748.1 hypothetical protein 1193344 7145978 EC55989_1130 Escherichia coli 55989 hypothetical protein YP_002402222.1 1193147 R 585055 CDS YP_002402223.1 218694556 7144530 1193564..1194487 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8444794, 2160940; Product type pe : enzyme; hypothetical protein 1194487 phoH 7144530 phoH Escherichia coli 55989 hypothetical protein YP_002402223.1 1193564 D 585055 CDS YP_002402224.1 218694557 7147182 complement(1194537..1194950) 1 NC_011748.1 in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export; PGA biosynthesis protein 1194950 pgaD 7147182 pgaD Escherichia coli 55989 PGA biosynthesis protein YP_002402224.1 1194537 R 585055 CDS YP_002402225.1 218694558 7147149 complement(1194952..1196277) 1 NC_011748.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein; N-glycosyltransferase 1196277 pgaC 7147149 pgaC Escherichia coli 55989 N-glycosyltransferase YP_002402225.1 1194952 R 585055 CDS YP_002402226.1 218694559 7147148 complement(1196270..1198288) 1 NC_011748.1 in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export; outer membrane N-deacetylase 1198288 pgaB 7147148 pgaB Escherichia coli 55989 outer membrane N-deacetylase YP_002402226.1 1196270 R 585055 CDS YP_002402227.1 218694560 7147147 complement(1198297..1200720) 1 NC_011748.1 outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia; outer membrane protein PgaA 1200720 pgaA 7147147 pgaA Escherichia coli 55989 outer membrane protein PgaA YP_002402227.1 1198297 R 585055 CDS YP_002402228.1 218694561 7147146 1201027..1201302 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 1201302 insA 7147146 insA Escherichia coli 55989 IS1 repressor protein InsA YP_002402228.1 1201027 D 585055 CDS YP_002402229.1 218694562 7146573 1201221..1201724 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 1201724 insB 7146573 insB Escherichia coli 55989 IS1 transposase InsAB' YP_002402229.1 1201221 D 585055 CDS YP_002402230.1 218694563 7146585 1201775..1202902 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10 1202902 7146585 EC55989_1138 Escherichia coli 55989 transposase, IS4 family, IS10 YP_002402230.1 1201775 D 585055 CDS YP_002402231.1 218694564 7148284 complement(1204591..1205457) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin; IS3 element protein InsF 1205457 insF 7148284 insF Escherichia coli 55989 IS3 element protein InsF YP_002402231.1 1204591 R 585055 CDS YP_002402232.1 218694565 7146594 complement(1205454..1205762) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin; IS3 element protein InsE 1205762 insE 7146594 insE Escherichia coli 55989 IS3 element protein InsE YP_002402232.1 1205454 R 585055 CDS YP_002402233.1 218694566 7146592 1205856..1206347 1 NC_011748.1 hypothetical protein 1206347 7146592 EC55989_1143 Escherichia coli 55989 hypothetical protein YP_002402233.1 1205856 D 585055 CDS YP_002402234.1 218694567 7144532 1206344..1207330 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1207330 ycdU 7144532 ycdU Escherichia coli 55989 inner membrane protein YP_002402234.1 1206344 D 585055 CDS YP_002402235.1 218694568 7145400 1208025..1208963 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11237876, 10493123; Product type e : enzyme; 2-ketoacid reductase 1208963 ycdW 7145400 ycdW Escherichia coli 55989 2-ketoacid reductase YP_002402235.1 1208025 D 585055 CDS YP_002402236.1 218694569 7148286 1209018..1209755 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12661000; Product type pe : enzyme; hydrolase 1209755 ycdX 7148286 ycdX Escherichia coli 55989 hydrolase YP_002402236.1 1209018 D 585055 CDS YP_002402237.1 218694570 7148287 1209779..1210333 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1210333 ycdY 7148287 ycdY Escherichia coli 55989 hypothetical protein YP_002402237.1 1209779 D 585055 CDS YP_002402238.1 218694571 7148288 1210435..1210926 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1210926 ycdZ 7148288 ycdZ Escherichia coli 55989 inner membrane protein YP_002402238.1 1210435 D 585055 CDS YP_002402239.1 218694572 7148289 complement(1210990..1211823) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8817489; Product type lp : lipoprotein; outer membrane lipoprotein involved in curli production assembly/transport 1211823 csgG 7148289 csgG Escherichia coli 55989 outer membrane lipoprotein involved in curli production assembly/transport YP_002402239.1 1210990 R 585055 CDS YP_002402240.1 218694573 7145774 complement(1211850..1212266) 1 NC_011748.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF 1212266 csgF 7145774 csgF Escherichia coli 55989 curli assembly protein CsgF YP_002402240.1 1211850 R 585055 CDS YP_002402241.1 218694574 7145773 complement(1212291..1212680) 1 NC_011748.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE 1212680 csgE 7145773 csgE Escherichia coli 55989 curli assembly protein CsgE YP_002402241.1 1212291 R 585055 CDS YP_002402242.1 218694575 7145772 complement(1212685..1213335) 1 NC_011748.1 activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD 1213335 csgD 7145772 csgD Escherichia coli 55989 DNA-binding transcriptional regulator CsgD YP_002402242.1 1212685 R 585055 CDS YP_002402243.1 218694576 7145771 1214089..1214544 1 NC_011748.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1214544 csgB 7145771 csgB Escherichia coli 55989 curlin minor subunit YP_002402243.1 1214089 D 585055 CDS YP_002402244.1 218694577 7145769 1214585..1215040 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89201357, 93023873, 1677357, 8459772, 8817489, 1357528; Product type s : structure; cryptic curlin major subunit 1215040 csgA 7145769 csgA Escherichia coli 55989 cryptic curlin major subunit YP_002402244.1 1214585 D 585055 CDS YP_002402245.1 218694578 7145768 1215099..1215431 1 NC_011748.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers; autoagglutination protein 1215431 csgC 7145768 csgC Escherichia coli 55989 autoagglutination protein YP_002402245.1 1215099 D 585055 CDS YP_002402246.1 218694579 7149268 1215957..1216490 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1216490 ymdB 7149268 ymdB Escherichia coli 55989 hypothetical protein YP_002402246.1 1215957 D 585055 CDS YP_002402247.1 218694580 7149269 1216492..1217913 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase 1217913 ymdC 7149269 ymdC Escherichia coli 55989 hydrolase YP_002402247.1 1216492 D 585055 CDS YP_002402248.1 218694581 7149270 complement(1217921..1219078) 1 NC_011748.1 required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein 1219078 mdoC 7149270 mdoC Escherichia coli 55989 glucans biosynthesis protein YP_002402248.1 1217921 R 585055 CDS YP_002402249.1 218694582 7146798 complement(1219123..1219266) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1219266 7146798 EC55989_1161 Escherichia coli 55989 hypothetical protein YP_002402249.1 1219123 R 585055 CDS YP_002402250.1 218694583 7144533 complement(1219270..1219428) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1219428 7144533 EC55989_1162 Escherichia coli 55989 hypothetical protein YP_002402250.1 1219270 R 585055 CDS YP_002402251.1 218694584 7144534 1219472..1221007 1 NC_011748.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1221007 mdoG 7144534 mdoG Escherichia coli 55989 glucan biosynthesis protein G YP_002402251.1 1219472 D 585055 CDS YP_002402252.1 218694585 7146800 1221000..1223543 1 NC_011748.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1223543 mdoH 7146800 mdoH Escherichia coli 55989 glucosyltransferase MdoH YP_002402252.1 1221000 D 585055 CDS YP_002402253.1 218694586 7146801 1223716..1223943 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 1223943 yceK 7146801 yceK Escherichia coli 55989 hypothetical protein YP_002402253.1 1223716 D 585055 CDS YP_002402254.1 218694587 7148298 complement(1223944..1224318) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165719; hypothetical protein 1224318 msyB 7148298 msyB Escherichia coli 55989 hypothetical protein YP_002402254.1 1223944 R 585055 CDS YP_002402255.1 218694588 7146912 complement(1224401..1225627) 1 NC_011748.1 Confers resistance to fosfomycin and deoxycholate; drug efflux system protein MdtG 1225627 mdtG 7146912 mdtG Escherichia coli 55989 drug efflux system protein MdtG YP_002402255.1 1224401 R 585055 CDS YP_002402256.1 218694589 7146808 complement(1225799..1226719) 1 NC_011748.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase 1226719 lpxL 7146808 lpxL Escherichia coli 55989 lipid A biosynthesis lauroyl acyltransferase YP_002402256.1 1225799 R 585055 CDS YP_002402257.1 218694590 7146741 1226944..1227996 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1840644; hypothetical protein 1227996 yceA 7146741 yceA Escherichia coli 55989 hypothetical protein YP_002402257.1 1226944 D 585055 CDS YP_002402258.1 218694591 7148290 complement(1228038..1228613) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15741337, 11298273, 1840644, 9298646; Product type c : carrier; hypothetical protein 1228613 yceI 7148290 yceI Escherichia coli 55989 hypothetical protein YP_002402258.1 1228038 R 585055 CDS YP_002402259.1 218694592 7148296 complement(1228617..1229183) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; cytochrome b561 1229183 yceJ 7148296 yceJ Escherichia coli 55989 cytochrome b561 YP_002402259.1 1228617 R 585055 CDS YP_002402260.1 218694593 7148297 complement(1229605..1230723) 1 NC_011748.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase 1230723 solA 7148297 solA Escherichia coli 55989 N-methyltryptophan oxidase YP_002402260.1 1229605 R 585055 CDS YP_002402261.1 218694594 7147678 complement(1230838..1231092) 1 NC_011748.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS 1231092 bssS 7147678 bssS Escherichia coli 55989 biofilm formation regulatory protein BssS YP_002402261.1 1230838 R 585055 CDS YP_002402262.2 229598870 7145638 complement(1231382..1231627) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11230150, 11152126; Product type f : factor; DNA damage-inducible protein I 1231627 dinI 7145638 dinI Escherichia coli 55989 DNA damage-inducible protein I YP_002402262.2 1231382 R 585055 CDS YP_002402263.1 218694596 7145918 complement(1231701..1232747) 1 NC_011748.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase 1232747 pyrC 7145918 pyrC Escherichia coli 55989 dihydroorotase YP_002402263.1 1231701 R 585055 CDS YP_002402264.1 218694597 7147318 complement(1232853..1233413) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 1233413 yceB 7147318 yceB Escherichia coli 55989 hypothetical protein YP_002402264.1 1232853 R 585055 CDS YP_002402265.1 218694598 7148291 complement(1233547..1234194) 1 NC_011748.1 cofactor involved in the reduction of disulfides; glutaredoxin 1234194 grxB 7148291 grxB Escherichia coli 55989 glutaredoxin YP_002402265.1 1233547 R 585055 CDS YP_002402266.1 218694599 7146371 complement(1234258..1235466) 1 NC_011748.1 Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH 1235466 mdtH 7146371 mdtH Escherichia coli 55989 multidrug resistance protein MdtH YP_002402266.1 1234258 R 585055 CDS YP_002402267.1 218694600 7146809 1235702..1236286 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88121676, 90136529, 1356970; Product type e : enzyme; ribosomal-protein-S5-alanine N-acetyltransferase 1236286 rimJ 7146809 rimJ Escherichia coli 55989 ribosomal-protein-S5-alanine N-acetyltransferase YP_002402267.1 1235702 D 585055 CDS YP_002402268.1 218694601 7147419 1236297..1236944 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1356970, 2828880; hypothetical protein 1236944 yceH 7147419 yceH Escherichia coli 55989 hypothetical protein YP_002402268.1 1236297 D 585055 CDS YP_002402269.1 218694602 7148295 1236946..1237869 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase with NAD(P)-binding Rossmann-fold domain 1237869 mviM 7148295 mviM Escherichia coli 55989 oxidoreductase with NAD(P)-binding Rossmann-fold domain YP_002402269.1 1236946 D 585055 CDS YP_002402270.1 218694603 7146937 1237979..1239514 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1239514 mviN 7146937 mviN Escherichia coli 55989 inner membrane protein YP_002402270.1 1237979 D 585055 CDS YP_002402271.1 218694604 7146938 complement(1239554..1239970) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10320579; Product type f : factor; export chaperone for FlgK and FlgL 1239970 flgN 7146938 flgN Escherichia coli 55989 export chaperone for FlgK and FlgL YP_002402271.1 1239554 R 585055 CDS YP_002402272.1 218694605 7146137 complement(1239975..1240268) 1 NC_011748.1 regulates the flagellar specific sigma28 transcription factor; anti-sigma-28 factor FlgM 1240268 flgM 7146137 flgM Escherichia coli 55989 anti-sigma-28 factor FlgM YP_002402272.1 1239975 R 585055 CDS YP_002402273.1 218694606 7146136 complement(1240344..1241003) 1 NC_011748.1 required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA 1241003 flgA 7146136 flgA Escherichia coli 55989 flagellar basal body P-ring biosynthesis protein FlgA YP_002402273.1 1240344 R 585055 CDS YP_002402274.1 218694607 7146124 1241158..1241574 1 NC_011748.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal-body rod protein FlgB 1241574 flgB 7146124 flgB Escherichia coli 55989 flagellar basal-body rod protein FlgB YP_002402274.1 1241158 D 585055 CDS YP_002402275.1 218694608 7146125 1241578..1241982 1 NC_011748.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1241982 flgC 7146125 flgC Escherichia coli 55989 flagellar basal body rod protein FlgC YP_002402275.1 1241578 D 585055 CDS YP_002402276.1 218694609 7146126 1241994..1242689 1 NC_011748.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1242689 flgD 7146126 flgD Escherichia coli 55989 flagellar basal body rod modification protein YP_002402276.1 1241994 D 585055 CDS YP_002402277.1 218694610 7146127 1242714..1243919 1 NC_011748.1 the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1243919 flgE 7146127 flgE Escherichia coli 55989 flagellar hook protein FlgE YP_002402277.1 1242714 D 585055 CDS YP_002402278.1 218694611 7146128 1243939..1244694 1 NC_011748.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1244694 flgF 7146128 flgF Escherichia coli 55989 flagellar basal body rod protein FlgF YP_002402278.1 1243939 D 585055 CDS YP_002402279.1 218694612 7146129 1244866..1245648 1 NC_011748.1 makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1245648 flgG 7146129 flgG Escherichia coli 55989 flagellar basal body rod protein FlgG YP_002402279.1 1244866 D 585055 CDS YP_002402280.1 218694613 7146130 1245701..1246399 1 NC_011748.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1246399 flgH 7146130 flgH Escherichia coli 55989 flagellar basal body L-ring protein YP_002402280.1 1245701 D 585055 CDS YP_002402281.1 218694614 7146131 1246411..1247508 1 NC_011748.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 1247508 flgI 7146131 flgI Escherichia coli 55989 flagellar basal body P-ring protein YP_002402281.1 1246411 D 585055 CDS YP_002402282.1 218694615 7146132 1247508..1248449 1 NC_011748.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1248449 flgJ 7146132 flgJ Escherichia coli 55989 flagellar rod assembly protein/muramidase FlgJ YP_002402282.1 1247508 D 585055 CDS YP_002402283.1 218694616 7146133 1248515..1250158 1 NC_011748.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1250158 flgK 7146133 flgK Escherichia coli 55989 flagellar hook-associated protein FlgK YP_002402283.1 1248515 D 585055 CDS YP_002402284.1 218694617 7146134 1250170..1251123 1 NC_011748.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1251123 flgL 7146134 flgL Escherichia coli 55989 flagellar hook-associated protein FlgL YP_002402284.1 1250170 D 585055 CDS YP_002402285.1 218694618 7146135 complement(1251320..1254505) 1 NC_011748.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E 1254505 rne 7146135 rne Escherichia coli 55989 ribonuclease E YP_002402285.1 1251320 R 585055 CDS YP_002402286.1 218694619 7145302 1255078..1256037 1 NC_011748.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1256037 rluC 7145302 rluC Escherichia coli 55989 23S rRNA pseudouridylate synthase C YP_002402286.1 1255078 D 585055 CDS YP_002402287.1 218694620 7147428 complement(1256149..1256733) 1 NC_011748.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 1256733 yceF 7147428 yceF Escherichia coli 55989 Maf-like protein YP_002402287.1 1256149 R 585055 CDS YP_002402288.1 218694621 7147699 1256932..1257453 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 90008815, 1447160; hypothetical protein 1257453 yceD 7147699 yceD Escherichia coli 55989 hypothetical protein YP_002402288.1 1256932 D 585055 CDS YP_002402289.1 218694622 7148292 1257505..1257678 1 NC_011748.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1257678 rpmF 7148292 rpmF Escherichia coli 55989 50S ribosomal protein L32 YP_002402289.1 1257505 D 585055 CDS YP_002402290.1 218694623 7147491 1257759..1258829 1 NC_011748.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1258829 plsX 7147491 plsX Escherichia coli 55989 glycerol-3-phosphate acyltransferase PlsX YP_002402290.1 1257759 D 585055 CDS YP_002402291.1 218694624 7147197 1258897..1259850 1 NC_011748.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1259850 fabH 7147197 fabH Escherichia coli 55989 3-oxoacyl-ACP synthase YP_002402291.1 1258897 D 585055 CDS YP_002402292.1 218694625 7146051 1259866..1260795 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052166, 92183950, 92210530, 92234941, 7700236, 7768883, 9298646; Product type e : enzyme; malonyl-CoA-[acyl-carrier-protein] transacylase 1260795 fabD 7146051 fabD Escherichia coli 55989 malonyl-CoA-[acyl-carrier-protein] transacylase YP_002402292.1 1259866 D 585055 CDS YP_002402293.1 218694626 7146048 1260808..1261542 1 NC_011748.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1261542 fabG 7146048 fabG Escherichia coli 55989 3-ketoacyl-ACP reductase YP_002402293.1 1260808 D 585055 CDS YP_002402294.1 218694627 7146050 1261753..1261989 1 NC_011748.1 carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1261989 acpP 7146050 acpP Escherichia coli 55989 acyl carrier protein YP_002402294.1 1261753 D 585055 CDS YP_002402295.1 218694628 7145441 1262077..1263318 1 NC_011748.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1263318 fabF 7145441 fabF Escherichia coli 55989 3-oxoacyl-ACP synthase YP_002402295.1 1262077 D 585055 CDS YP_002402296.1 218694629 7146049 1263438..1264247 1 NC_011748.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1264247 pabC 7146049 pabC Escherichia coli 55989 4-amino-4-deoxychorismate lyase YP_002402296.1 1263438 D 585055 CDS YP_002402297.1 218694630 7147108 1264250..1265272 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; hypothetical protein 1265272 yceG 7147108 yceG Escherichia coli 55989 hypothetical protein YP_002402297.1 1264250 D 585055 CDS YP_002402298.1 218694631 7148294 1265262..1265903 1 NC_011748.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1265903 tmk 7148294 tmk Escherichia coli 55989 thymidylate kinase YP_002402298.1 1265262 D 585055 CDS YP_002402299.1 218694632 7147807 1265900..1266904 1 NC_011748.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1266904 holB 7147807 holB Escherichia coli 55989 DNA polymerase III subunit delta' YP_002402299.1 1265900 D 585055 CDS YP_002402300.1 218694633 7146454 1266915..1267712 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8505303, 8509334, 10747959; Product type pe : enzyme; metallodependent hydrolase 1267712 ycfH 7146454 ycfH Escherichia coli 55989 metallodependent hydrolase YP_002402300.1 1266915 D 585055 CDS YP_002402301.1 218694634 7148300 1268007..1269440 1 NC_011748.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunit IIBC 1269440 ptsG 7148300 ptsG Escherichia coli 55989 PTS system glucose-specific transporter subunit IIBC YP_002402301.1 1268007 D 585055 CDS YP_002402302.1 218694635 7147286 complement(1269500..1271689) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90286919, 3032906, 10529396; Product type t : transporter; ferric-rhodotorulic acid outer membrane transporter 1271689 fhuE 7147286 fhuE Escherichia coli 55989 ferric-rhodotorulic acid outer membrane transporter YP_002402302.1 1269500 R 585055 CDS YP_002402303.1 218694636 7146103 1272023..1272382 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15703176, 10493123, 2162465; Product type e : enzyme; purine nucleoside phosphoramidase 1272382 hinT 7146103 hinT Escherichia coli 55989 purine nucleoside phosphoramidase YP_002402303.1 1272023 D 585055 CDS YP_002402304.1 218694637 7146427 1272385..1272762 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1272762 ycfL 7146427 ycfL Escherichia coli 55989 hypothetical protein YP_002402304.1 1272385 D 585055 CDS YP_002402305.1 218694638 7148302 1272776..1273417 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; outer membrane lipoprotein 1273417 ycfM 7148302 ycfM Escherichia coli 55989 outer membrane lipoprotein YP_002402305.1 1272776 D 585055 CDS YP_002402306.1 218694639 7148303 1273398..1274222 1 NC_011748.1 catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1274222 thiK 7148303 thiK Escherichia coli 55989 thiamine kinase YP_002402306.1 1273398 D 585055 CDS YP_002402307.1 218694640 7148304 1274233..1275258 1 NC_011748.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1275258 nagZ 7148304 nagZ Escherichia coli 55989 beta-hexosaminidase YP_002402307.1 1274233 D 585055 CDS YP_002402308.1 218694641 7146953 1275281..1275823 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1275823 ycfP 7146953 ycfP Escherichia coli 55989 hypothetical protein YP_002402308.1 1275281 D 585055 CDS YP_002402309.1 218694642 7148305 1276231..1277535 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766919, 20130027, 81256452, 92296775, 94042945, 99441207, 6265208; Product type e : enzyme; respiratory NADH dehydrogenase 2/cupric reductase 1277535 ndh 7148305 ndh Escherichia coli 55989 respiratory NADH dehydrogenase 2/cupric reductase YP_002402309.1 1276231 D 585055 CDS YP_002402310.1 218694643 7146981 1277745..1278284 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6265208, 7984428; hypothetical protein 1278284 ycfJ 7146981 ycfJ Escherichia coli 55989 hypothetical protein YP_002402310.1 1277745 D 585055 CDS YP_002402311.1 218694644 7148301 complement(1278346..1278978) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1278978 ycfQ 7148301 ycfQ Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402311.1 1278346 R 585055 CDS YP_002402312.1 218694645 7148306 1279219..1279476 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; hypothetical protein 1279476 ycfR 7148306 ycfR Escherichia coli 55989 hypothetical protein YP_002402312.1 1279219 D 585055 CDS YP_002402313.1 218694646 7148307 complement(1279559..1280521) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1280521 ycfS 7148307 ycfS Escherichia coli 55989 hypothetical protein YP_002402313.1 1279559 R 585055 CDS YP_002402314.1 218694647 7148308 complement(1280665..1284111) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14602898, 90158497, 92107993, 8465200; Product type f : factor; transcription-repair coupling factor 1284111 mfd 7148308 mfd Escherichia coli 55989 transcription-repair coupling factor YP_002402314.1 1280665 R 585055 CDS YP_002402315.1 218694648 7146838 complement(1284239..1285312) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1285312 ycfT 7146838 ycfT Escherichia coli 55989 inner membrane protein YP_002402315.1 1284239 R 585055 CDS YP_002402316.1 218694649 7148309 1285574..1286773 1 NC_011748.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1286773 lolC 7148309 lolC Escherichia coli 55989 outer membrane-specific lipoprotein transporter subunit LolC YP_002402316.1 1285574 D 585055 CDS YP_002402317.1 218694650 7146717 1286766..1287467 1 NC_011748.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1287467 lolD 7146717 lolD Escherichia coli 55989 lipoprotein transporter ATP-binding subunit YP_002402317.1 1286766 D 585055 CDS YP_002402318.1 218694651 7146718 1287467..1288711 1 NC_011748.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1288711 lolE 7146718 lolE Escherichia coli 55989 outer membrane-specific lipoprotein transporter subunit LolE YP_002402318.1 1287467 D 585055 CDS YP_002402319.1 218694652 7146719 1288740..1289651 1 NC_011748.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1289651 ycfX 7146719 ycfX Escherichia coli 55989 N-acetyl-D-glucosamine kinase YP_002402319.1 1288740 D 585055 CDS YP_002402320.1 218694653 7148310 1289667..1290488 1 NC_011748.1 Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1290488 cobB 7148310 cobB Escherichia coli 55989 NAD-dependent deacetylase YP_002402320.1 1289667 D 585055 CDS YP_002402321.1 218694654 7145735 complement(1290627..1291349) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1291349 ycfZ 7145735 ycfZ Escherichia coli 55989 inner membrane protein YP_002402321.1 1290627 R 585055 CDS YP_002402322.1 218694655 7148311 complement(1291412..1291882) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1291882 7148311 EC55989_1234 Escherichia coli 55989 hypothetical protein YP_002402322.1 1291412 R 585055 CDS YP_002402323.1 218694656 7144535 complement(1291931..1292977) 1 NC_011748.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter substrate-binding protein 1292977 potD 7144535 potD Escherichia coli 55989 spermidine/putrescine ABC transporter substrate-binding protein YP_002402323.1 1291931 R 585055 CDS YP_002402324.1 218694657 7147212 complement(1292974..1293768) 1 NC_011748.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein 1293768 potC 7147212 potC Escherichia coli 55989 spermidine/putrescine ABC transporter membrane protein YP_002402324.1 1292974 R 585055 CDS YP_002402325.1 218694658 7147211 complement(1293765..1294592) 1 NC_011748.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein 1294592 potB 7147211 potB Escherichia coli 55989 spermidine/putrescine ABC transporter membrane protein YP_002402325.1 1293765 R 585055 CDS YP_002402326.1 218694659 7147210 complement(1294606..1295742) 1 NC_011748.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase 1295742 potA 7147210 potA Escherichia coli 55989 putrescine/spermidine ABC transporter ATPase YP_002402326.1 1294606 R 585055 CDS YP_002402327.1 218694660 7147209 complement(1295721..1295972) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1295972 7147209 EC55989_1239 Escherichia coli 55989 hypothetical protein YP_002402327.1 1295721 R 585055 CDS YP_002402328.1 218694661 7144536 1295950..1297221 1 NC_011748.1 catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1297221 pepT 7144536 pepT Escherichia coli 55989 peptidase T YP_002402328.1 1295950 D 585055 CDS YP_002402329.1 218694662 7147137 complement(1297367..1298488) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1298488 ycfD 7147137 ycfD Escherichia coli 55989 hypothetical protein YP_002402329.1 1297367 R 585055 CDS YP_002402330.1 218694663 7148299 complement(1298564..1300024) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105017; Product type r : regulator; sensor protein PhoQ 1300024 phoQ 7148299 phoQ Escherichia coli 55989 sensor protein PhoQ YP_002402330.1 1298564 R 585055 CDS YP_002402331.1 218694664 7147184 complement(1300024..1300695) 1 NC_011748.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP 1300695 phoP 7147184 phoP Escherichia coli 55989 DNA-binding transcriptional regulator PhoP YP_002402331.1 1300024 R 585055 CDS YP_002402332.1 218694665 7147183 complement(1300863..1302233) 1 NC_011748.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase 1302233 purB 7147183 purB Escherichia coli 55989 adenylosuccinate lyase YP_002402332.1 1300863 R 585055 CDS YP_002402333.1 218694666 7147293 complement(1302237..1302878) 1 NC_011748.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein 1302878 hflD 7147293 hflD Escherichia coli 55989 hypothetical protein YP_002402333.1 1302237 R 585055 CDS YP_002402334.1 218694667 7146421 complement(1302914..1304020) 1 NC_011748.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA 1304020 mnmA 7146421 mnmA Escherichia coli 55989 tRNA-specific 2-thiouridylase MnmA YP_002402334.1 1302914 R 585055 CDS YP_002402335.1 218694668 7147849 complement(1304074..1304535) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; bifunctional thiamin pyrimidine pyrophosphate hydrolase and thiamin pyrophosphate hydrolase 1304535 ymfB 7147849 ymfB Escherichia coli 55989 bifunctional thiamin pyrimidine pyrophosphate hydrolase and thiamin pyrophosphate hydrolase YP_002402335.1 1304074 R 585055 CDS YP_002402336.1 218694669 7149272 complement(1304545..1305198) 1 NC_011748.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E 1305198 ymfC 7149272 ymfC Escherichia coli 55989 23S rRNA pseudouridine synthase E YP_002402336.1 1304545 R 585055 CDS YP_002402337.1 218694670 7149273 1305370..1306620 1 NC_011748.1 Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1306620 icd 7149273 icd Escherichia coli 55989 isocitrate dehydrogenase YP_002402337.1 1305370 D 585055 CDS YP_002402338.1 218694671 7146537 complement(1306723..1307046) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9603997; hypothetical protein 1307046 elbA 7146537 elbA Escherichia coli 55989 hypothetical protein YP_002402338.1 1306723 R 585055 CDS YP_002402339.1 218694672 7145987 complement(1307742..1308146) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1308146 ycgX 7145987 ycgX Escherichia coli 55989 hypothetical protein YP_002402339.1 1307742 R 585055 CDS YP_002402340.1 218694673 7148323 complement(1308367..1309098) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1309098 ycgE 7148323 ycgE Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402340.1 1308367 R 585055 CDS YP_002402341.1 218694674 7148313 complement(1309303..1310514) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16533062, 15453820; Product type pe : enzyme; cyclic-di-GMP phosphodiesterase; blue-light sensing protein using FAD (BLUF) 1310514 ycgF 7148313 ycgF Escherichia coli 55989 cyclic-di-GMP phosphodiesterase; blue-light sensing protein using FAD (BLUF) YP_002402341.1 1309303 R 585055 CDS YP_002402342.1 218694675 7148314 1310828..1311064 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1311064 ycgZ 7148314 ycgZ Escherichia coli 55989 hypothetical protein YP_002402342.1 1310828 D 585055 CDS YP_002402343.1 218694676 7148325 1311107..1311379 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1311379 ymgA 7148325 ymgA Escherichia coli 55989 hypothetical protein YP_002402343.1 1311107 D 585055 CDS YP_002402344.1 218694677 7149275 1311408..1311674 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1311674 ymgB 7149275 ymgB Escherichia coli 55989 hypothetical protein YP_002402344.1 1311408 D 585055 CDS YP_002402345.1 218694678 7149276 1311787..1312035 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1312035 ymgC 7149276 ymgC Escherichia coli 55989 hypothetical protein YP_002402345.1 1311787 D 585055 CDS YP_002402346.1 218694679 7149277 1312367..1313890 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1313890 ycgG 7149277 ycgG Escherichia coli 55989 inner membrane protein YP_002402346.1 1312367 D 585055 CDS YP_002402347.1 218694680 7148315 1314022..1314240 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1314240 ymgF 7148315 ymgF Escherichia coli 55989 hypothetical protein YP_002402347.1 1314022 D 585055 CDS YP_002402348.1 218694681 7149280 1314640..1314849 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1314849 7149280 EC55989_1260 Escherichia coli 55989 hypothetical protein YP_002402348.1 1314640 D 585055 CDS YP_002402349.1 218694682 7144537 1315056..1315331 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 1315331 insA 7144537 insA Escherichia coli 55989 IS1 repressor protein InsA YP_002402349.1 1315056 D 585055 CDS YP_002402350.1 218694683 7146574 1315250..1315753 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 1315753 insB 7146574 insB Escherichia coli 55989 IS1 transposase InsAB' YP_002402350.1 1315250 D 585055 CDS YP_002402351.1 218694684 7146586 1315755..1318064 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; Outer membrane autotransporter barrel, pectin lyase fold 1318064 7146586 EC55989_1263 Escherichia coli 55989 Outer membrane autotransporter barrel, pectin lyase fold YP_002402351.1 1315755 D 585055 CDS YP_002402352.1 218694685 7144538 complement(1318121..1318450) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1318450 ymgD 7144538 ymgD Escherichia coli 55989 hypothetical protein YP_002402352.1 1318121 R 585055 CDS YP_002402353.1 218694686 7149278 complement(1318460..1318735) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1318735 ymgG 7149278 ymgG Escherichia coli 55989 hypothetical protein YP_002402353.1 1318460 R 585055 CDS YP_002402354.1 218694687 7149281 1319281..1319724 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1319724 7149281 EC55989_1266 Escherichia coli 55989 hypothetical protein YP_002402354.1 1319281 D 585055 CDS YP_002402355.1 218694688 7144539 complement(1320096..1320362) 1 NC_011748.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE 1320362 minE 7144539 minE Escherichia coli 55989 cell division topological specificity factor MinE YP_002402355.1 1320096 R 585055 CDS YP_002402356.1 218694689 7146859 complement(1320366..1321178) 1 NC_011748.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD 1321178 minD 7146859 minD Escherichia coli 55989 cell division inhibitor MinD YP_002402356.1 1320366 R 585055 CDS YP_002402357.1 218694690 7146858 complement(1321202..1321897) 1 NC_011748.1 blocks the formation of polar Z-ring septums; septum formation inhibitor 1321897 minC 7146858 minC Escherichia coli 55989 septum formation inhibitor YP_002402357.1 1321202 R 585055 CDS YP_002402358.1 218694691 7146857 1322417..1322785 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1322785 ycgJ 7146857 ycgJ Escherichia coli 55989 hypothetical protein YP_002402358.1 1322417 D 585055 CDS YP_002402359.1 218694692 7148316 complement(1322905..1323306) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1323306 ycgK 7148316 ycgK Escherichia coli 55989 hypothetical protein YP_002402359.1 1322905 R 585055 CDS YP_002402360.1 218694693 7148317 1323515..1323841 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1323841 ycgL 7148317 ycgL Escherichia coli 55989 hypothetical protein YP_002402360.1 1323515 D 585055 CDS YP_002402361.1 218694694 7148318 1323913..1324572 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15551868; Product type pe : enzyme; hypothetical protein 1324572 ycgM 7148318 ycgM Escherichia coli 55989 hypothetical protein YP_002402361.1 1323913 D 585055 CDS YP_002402362.1 218694695 7148319 1324664..1325110 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1325110 ycgN 7148319 ycgN Escherichia coli 55989 hypothetical protein YP_002402362.1 1324664 D 585055 CDS YP_002402363.1 218694696 7146446 complement(1326117..1326371) 1 NC_011748.1 hypothetical protein 1326371 7146446 EC55989_1277 Escherichia coli 55989 hypothetical protein YP_002402363.1 1326117 R 585055 CDS YP_002402364.1 218694697 7145648 1326600..1327019 1 NC_011748.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1327019 umuD 7145648 umuD Escherichia coli 55989 DNA polymerase V subunit UmuD YP_002402364.1 1326600 D 585055 CDS YP_002402365.1 218694698 7147922 1327019..1328287 1 NC_011748.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1328287 umuC 7147922 umuC Escherichia coli 55989 DNA polymerase V subunit UmuC YP_002402365.1 1327019 D 585055 CDS YP_002402366.1 218694699 7147921 complement(1328333..1328863) 1 NC_011748.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B 1328863 dsbB 7147921 dsbB Escherichia coli 55989 disulfide bond formation protein B YP_002402366.1 1328333 R 585055 CDS YP_002402367.1 218694700 7145951 complement(1329009..1330550) 1 NC_011748.1 involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter 1330550 nhaB 7145951 nhaB Escherichia coli 55989 sodium/proton antiporter YP_002402367.1 1329009 R 585055 CDS YP_002402368.1 218694701 7146992 1330772..1331491 1 NC_011748.1 Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1331491 fadR 7146992 fadR Escherichia coli 55989 fatty acid metabolism regulator YP_002402368.1 1330772 D 585055 CDS YP_002402369.1 218694702 7146061 complement(1331543..1333075) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; SpoVR family protein 1333075 ycgB 7146061 ycgB Escherichia coli 55989 SpoVR family protein YP_002402369.1 1331543 R 585055 CDS YP_002402370.1 218694703 7148312 1333405..1334703 1 NC_011748.1 catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1334703 dadA 7148312 dadA Escherichia coli 55989 D-amino acid dehydrogenase small subunit YP_002402370.1 1333405 D 585055 CDS YP_002402371.1 218694704 7145845 1334713..1335783 1 NC_011748.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1335783 dadX 7145845 dadX Escherichia coli 55989 alanine racemase YP_002402371.1 1334713 D 585055 CDS YP_002402372.1 218694705 7145846 complement(1336169..1337905) 1 NC_011748.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter 1337905 cvrA 7145846 cvrA Escherichia coli 55989 potassium/proton antiporter YP_002402372.1 1336169 R 585055 CDS YP_002402373.1 218694706 7145801 complement(1338000..1338914) 1 NC_011748.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A 1338914 ldcA 7145801 ldcA Escherichia coli 55989 L,D-carboxypeptidase A YP_002402373.1 1338000 R 585055 CDS YP_002402374.1 218694707 7146680 1339014..1339625 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98317285; Product type e : enzyme; lytic murein endotransglycosylase E 1339625 emtA 7146680 emtA Escherichia coli 55989 lytic murein endotransglycosylase E YP_002402374.1 1339014 D 585055 CDS YP_002402375.1 218694708 7145996 complement(1339627..1340361) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11031114; Product type cp : cell process; protein involved in flagellar function 1340361 ycgR 7145996 ycgR Escherichia coli 55989 protein involved in flagellar function YP_002402375.1 1339627 R 585055 CDS YP_002402376.1 218694709 7148321 1340562..1340816 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; inner membrane protein with transglycosylase-associated domain 1340816 ymgE 7148321 ymgE Escherichia coli 55989 inner membrane protein with transglycosylase-associated domain YP_002402376.1 1340562 D 585055 CDS YP_002402377.1 218694710 7149279 1340994..1341434 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1341434 ycgY 7149279 ycgY Escherichia coli 55989 hypothetical protein YP_002402377.1 1340994 D 585055 CDS YP_002402378.1 218694711 7148324 complement(1341513..1343210) 1 NC_011748.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase 1343210 treA 7148324 treA Escherichia coli 55989 trehalase YP_002402378.1 1341513 R 585055 CDS YP_002402379.1 218694712 7147835 complement(1343530..1344948) 1 NC_011748.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit DhaM 1344948 dhaH 7147835 dhaH Escherichia coli 55989 dihydroxyacetone kinase subunit DhaM YP_002402379.1 1343530 R 585055 CDS YP_002402380.1 218694713 7145902 complement(1344959..1345591) 1 NC_011748.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL 1345591 dhaL 7145902 dhaL Escherichia coli 55989 dihydroxyacetone kinase subunit DhaL YP_002402380.1 1344959 R 585055 CDS YP_002402381.1 218694714 7145904 complement(1345602..1346672) 1 NC_011748.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK 1346672 dhaK 7145904 dhaK Escherichia coli 55989 dihydroxyacetone kinase subunit DhaK YP_002402381.1 1345602 R 585055 CDS YP_002402382.1 218694715 7145903 1346900..1348819 1 NC_011748.1 Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1348819 dhaR 7145903 dhaR Escherichia coli 55989 DNA-binding transcriptional regulator DhaR YP_002402382.1 1346900 D 585055 CDS YP_002402383.1 218694716 7145905 complement(1348919..1351786) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15659678; Product type pf : factor; adhesin; autotransporter 1351786 ycgV 7145905 ycgV Escherichia coli 55989 adhesin; autotransporter YP_002402383.1 1348919 R 585055 CDS YP_002402384.1 218694717 7148322 complement(1352555..1353646) 1 NC_011748.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD 1353646 ychF 7148322 ychF Escherichia coli 55989 GTP-dependent nucleic acid-binding protein EngD YP_002402384.1 1352555 R 585055 CDS YP_002402385.1 218694718 7148328 complement(1353763..1354347) 1 NC_011748.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase 1354347 pth 7148328 pth Escherichia coli 55989 peptidyl-tRNA hydrolase YP_002402385.1 1353763 R 585055 CDS YP_002402386.1 218694719 7147282 1354625..1354903 1 NC_011748.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1354903 ychH 7147282 ychH Escherichia coli 55989 hypothetical protein YP_002402386.1 1354625 D 585055 CDS YP_002402387.1 218694720 7148330 complement(1354958..1356637) 1 NC_011748.1 role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; sulfate transporter YchM 1356637 ychM 7148330 ychM Escherichia coli 55989 sulfate transporter YchM YP_002402387.1 1354958 R 585055 CDS YP_002402388.1 218694721 7148332 complement(1356762..1357709) 1 NC_011748.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase 1357709 prsA 7148332 prsA Escherichia coli 55989 ribose-phosphate pyrophosphokinase YP_002402388.1 1356762 R 585055 CDS YP_002402389.1 218694722 7147267 complement(1357860..1358711) 1 NC_011748.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase 1358711 ipk 7147267 ipk Escherichia coli 55989 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase YP_002402389.1 1357860 R 585055 CDS YP_002402390.1 218694723 7146628 complement(1358711..1359334) 1 NC_011748.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB 1359334 lolB 7146628 lolB Escherichia coli 55989 outer membrane lipoprotein LolB YP_002402390.1 1358711 R 585055 CDS YP_002402391.1 218694724 7146716 1359548..1360804 1 NC_011748.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1360804 hemA 7146716 hemA Escherichia coli 55989 glutamyl-tRNA reductase YP_002402391.1 1359548 D 585055 CDS YP_002402392.1 218694725 7146407 1360846..1361928 1 NC_011748.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1361928 prfA 7146407 prfA Escherichia coli 55989 peptide chain release factor 1 YP_002402392.1 1360846 D 585055 CDS YP_002402393.1 218694726 7147240 1361928..1362761 1 NC_011748.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1362761 prmC 7147240 prmC Escherichia coli 55989 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_002402393.1 1361928 D 585055 CDS YP_002402394.1 218694727 7147251 1362758..1363150 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : regulator; transcriptional regulator 1363150 ychQ 7147251 ychQ Escherichia coli 55989 transcriptional regulator YP_002402394.1 1362758 D 585055 CDS YP_002402395.1 218694728 7148335 1363154..1363963 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : regulator; transcriptional regulator 1363963 ychA 7148335 ychA Escherichia coli 55989 transcriptional regulator YP_002402395.1 1363154 D 585055 CDS YP_002402396.1 218694729 7148326 1363999..1364853 1 NC_011748.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1364853 kdsA 7148326 kdsA Escherichia coli 55989 2-dehydro-3-deoxyphosphooctonate aldolase YP_002402396.1 1363999 D 585055 CDS YP_002402397.1 218694730 7146659 complement(1365002..1365169) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; small toxic polypeptide 1365169 ldrB 7146659 ldrB Escherichia coli 55989 small toxic polypeptide YP_002402397.1 1365002 R 585055 CDS YP_002402398.1 218694731 7147353 complement(1365538..1365645) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type f : factor; toxic polypeptide, small 1365645 ldrB 7147353 ldrB Escherichia coli 55989 toxic polypeptide, small YP_002402398.1 1365538 R 585055 CDS YP_002402399.1 218694732 7147354 complement(1366050..1367150) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93266586, 94193576, 94292460; Product type t : transporter; calcium/sodium:proton antiporter 1367150 chaA 7147354 chaA Escherichia coli 55989 calcium/sodium:proton antiporter YP_002402399.1 1366050 R 585055 CDS YP_002402400.1 218694733 7145688 1367420..1367650 1 NC_011748.1 in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1367650 chaB 7145688 chaB Escherichia coli 55989 cation transport regulator YP_002402400.1 1367420 D 585055 CDS YP_002402401.1 218694734 7145689 1367787..1368503 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type r : regulator; regulatory protein for cation transport 1368503 chaC 7145689 chaC Escherichia coli 55989 regulatory protein for cation transport YP_002402401.1 1367787 D 585055 CDS YP_002402402.1 218694735 7145690 complement(1368547..1368900) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1368900 ychN 7145690 ychN Escherichia coli 55989 hypothetical protein YP_002402402.1 1368547 R 585055 CDS YP_002402403.1 218694736 7148333 1369226..1370479 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pf : factor; hypothetical protein 1370479 ychP 7148333 ychP Escherichia coli 55989 hypothetical protein YP_002402403.1 1369226 D 585055 CDS YP_002402404.1 218694737 7148334 complement(1370480..1371130) 1 NC_011748.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL 1371130 narL 7148334 narL Escherichia coli 55989 transcriptional regulator NarL YP_002402404.1 1370480 R 585055 CDS YP_002402405.1 218694738 7146972 complement(1371123..1372919) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92276349, 92374842, 94083940, 2649492, 2657652, 2668029; Product type r : regulator; nitrate/nitrite sensor protein NarX 1372919 narX 7146972 narX Escherichia coli 55989 nitrate/nitrite sensor protein NarX YP_002402405.1 1371123 R 585055 CDS YP_002402406.1 218694739 7146978 1373258..1374649 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91258310, 2657652, 2668029; Product type t : transporter; nitrate/nitrite transporter 1374649 narK 7146978 narK Escherichia coli 55989 nitrate/nitrite transporter YP_002402406.1 1373258 D 585055 CDS YP_002402407.1 218694740 7146971 1375165..1378908 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 2233673, 2668029, 2995309, 3053688, 3308846, 6094247; Product type e : enzyme; nitrate reductase 1 subunit alpha 1378908 narG 7146971 narG Escherichia coli 55989 nitrate reductase 1 subunit alpha YP_002402407.1 1375165 D 585055 CDS YP_002402408.1 218694741 7146967 1378905..1380443 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 1321049, 2832376, 3053688, 8383531, 8388253, 8664273, 9516445; Product type c : carrier; nitrate reductase 1 subunit, beta (Fe-S) 1380443 narH 7146967 narH Escherichia coli 55989 nitrate reductase 1 subunit, beta (Fe-S) YP_002402408.1 1378905 D 585055 CDS YP_002402409.1 218694742 7146968 1380440..1381150 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89384449, 92121125, 9632249, 2832376; Product type f : factor; molybdenum-cofactor-assembly chaperone subunit (delta subunit) of nitrate reductase 1 1381150 narJ 7146968 narJ Escherichia coli 55989 molybdenum-cofactor-assembly chaperone subunit (delta subunit) of nitrate reductase 1 YP_002402409.1 1380440 D 585055 CDS YP_002402410.1 218694743 7146970 1381150..1381827 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 75114694, 89384449, 92121125, 2832376, 3053688; Product type c : carrier; nitrate reductase 1 subunit gamma (cytochrome b(NR)) 1381827 narI 7146970 narI Escherichia coli 55989 nitrate reductase 1 subunit gamma (cytochrome b(NR)) YP_002402410.1 1381150 D 585055 CDS YP_002402412.1 218694745 7145398 complement(1382552..1383394) 1 NC_011748.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase 1383394 purU 7145398 purU Escherichia coli 55989 formyltetrahydrofolate deformylase YP_002402412.1 1382552 R 585055 CDS YP_002402413.1 218694746 7147305 complement(1383444..1383902) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1383902 ychJ 7147305 ychJ Escherichia coli 55989 hypothetical protein YP_002402413.1 1383444 R 585055 CDS YP_002402414.1 218694747 7148331 1383976..1384920 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 1384920 rssA 7148331 rssA Escherichia coli 55989 hypothetical protein YP_002402414.1 1383976 D 585055 CDS YP_002402415.1 218694748 7147541 1385012..1386025 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339606, 12912910, 9495753; Product type r : regulator; response regulator of RpoS 1386025 rssB 7147541 rssB Escherichia coli 55989 response regulator of RpoS YP_002402415.1 1385012 D 585055 CDS YP_002402416.1 218694749 7147542 1386227..1387135 1 NC_011748.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 1387135 galU 7147542 galU Escherichia coli 55989 UTP-glucose-1-phosphate uridylyltransferase YP_002402416.1 1386227 D 585055 CDS YP_002402417.1 218694750 7146255 complement(1387279..1387692) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 94335643, 95267838, 95286558, 99355427, 2404280, 11298273; Product type r : regulator; global DNA-binding transcriptional dual regulator H-NS 1387692 hns 7146255 hns Escherichia coli 55989 global DNA-binding transcriptional dual regulator H-NS YP_002402417.1 1387279 R 585055 CDS YP_002402418.1 218694751 7146448 1388298..1388915 1 NC_011748.1 catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1388915 tdk 7146448 tdk Escherichia coli 55989 thymidine kinase YP_002402418.1 1388298 D 585055 CDS YP_002402419.1 218694752 7147772 complement(1389197..1389739) 1 NC_011748.1 hypothetical protein 1389739 7147772 EC55989_1334 Escherichia coli 55989 hypothetical protein YP_002402419.1 1389197 R 585055 CDS YP_002402420.1 218694753 7144542 complement(1389743..1389973) 1 NC_011748.1 hypothetical protein 1389973 7144542 EC55989_1335 Escherichia coli 55989 hypothetical protein YP_002402420.1 1389743 R 585055 CDS YP_002402421.1 218694754 7144543 complement(1389912..1390097) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; transposase 1390097 ychG 7144543 ychG Escherichia coli 55989 transposase YP_002402421.1 1389912 R 585055 CDS YP_002402422.1 218694755 7148329 complement(1390221..1392896) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12783863, 4301680, 89291706, 91200315; Product type e : enzyme; bifunctional acetaldehyde-CoA/alcohol dehydrogenase 1392896 adhE 7148329 adhE Escherichia coli 55989 bifunctional acetaldehyde-CoA/alcohol dehydrogenase YP_002402422.1 1390221 R 585055 CDS YP_002402423.1 218694756 7145455 1393373..1394020 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 1394020 ychE 7145455 ychE Escherichia coli 55989 hypothetical protein YP_002402423.1 1393373 D 585055 CDS YP_002402424.1 218694757 7144544 1394758..1396389 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20256410, 86111605, 90256748, 92325017, 2015910, 9298646, 9600841, 2187863, 8740179, 9740056, 10972807; Product type t : transporter; oligopeptide transporter subunit ; periplasmic-binding component of ABC superfamily 1396389 oppA 7144544 oppA Escherichia coli 55989 oligopeptide transporter subunit ; periplasmic-binding component of ABC superfamily YP_002402424.1 1394758 D 585055 CDS YP_002402425.1 218694758 7147075 1396475..1397395 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606, 93106975, 2187863; Product type t : transporter; oligopeptide transporter permease 1397395 oppB 7147075 oppB Escherichia coli 55989 oligopeptide transporter permease YP_002402425.1 1396475 D 585055 CDS YP_002402426.1 218694759 7147076 1397410..1398318 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide transporter subunit ; membrane component of ABC superfamily 1398318 oppC 7147076 oppC Escherichia coli 55989 oligopeptide transporter subunit ; membrane component of ABC superfamily YP_002402426.1 1397410 D 585055 CDS YP_002402427.1 218694760 7147077 1398330..1399343 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide ABC transporter ATP-binding protein 1399343 oppD 7147077 oppD Escherichia coli 55989 oligopeptide ABC transporter ATP-binding protein YP_002402427.1 1398330 D 585055 CDS YP_002402428.1 218694761 7147078 1399340..1400344 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide transporter subunit ; ATP-binding component of ABC superfamily 1400344 oppF 7147078 oppF Escherichia coli 55989 oligopeptide transporter subunit ; ATP-binding component of ABC superfamily YP_002402428.1 1399340 D 585055 CDS YP_002402429.1 218694762 7147079 complement(1400397..1400726) 1 NC_011748.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein 1400726 yciU 7147079 yciU Escherichia coli 55989 dsDNA-mimic protein YP_002402429.1 1400397 R 585055 CDS YP_002402430.1 218694763 7148352 complement(1400761..1402221) 1 NC_011748.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase 1402221 cls 7148352 cls Escherichia coli 55989 cardiolipin synthetase YP_002402430.1 1400761 R 585055 CDS YP_002402431.1 218694764 7145727 1402253..1402537 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1402537 7145727 EC55989_1347 Escherichia coli 55989 hypothetical protein YP_002402431.1 1402253 D 585055 CDS YP_002402432.1 218694765 7144545 complement(1402592..1403845) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12220501, 12912904, 94224769, 98319474; Product type t : transporter; voltage-gated potassium channel 1403845 kch 7144545 kch Escherichia coli 55989 voltage-gated potassium channel YP_002402432.1 1402592 R 585055 CDS YP_002402433.1 218694766 7146650 complement(1404145..1404441) 1 NC_011748.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; hypothetical protein 1404441 yciI 7146650 yciI Escherichia coli 55989 hypothetical protein YP_002402433.1 1404145 R 585055 CDS YP_002402434.1 218694767 7148346 1404665..1405384 1 NC_011748.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transporter 1405384 tonB 7148346 tonB Escherichia coli 55989 transporter YP_002402434.1 1404665 D 585055 CDS YP_002402435.1 218694768 7147817 complement(1405424..1405822) 1 NC_011748.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins; acyl-CoA thioester hydrolase 1405822 yciA 7147817 yciA Escherichia coli 55989 acyl-CoA thioester hydrolase YP_002402435.1 1405424 R 585055 CDS YP_002402436.1 218694769 7148336 complement(1405927..1406466) 1 NC_011748.1 Involved in cell division; probably involved in intracellular septation; intracellular septation protein A 1406466 yciB 7148336 yciB Escherichia coli 55989 intracellular septation protein A YP_002402436.1 1405927 R 585055 CDS YP_002402437.1 218694770 7148337 complement(1406496..1407239) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 1407239 yciC 7148337 yciC Escherichia coli 55989 hypothetical protein YP_002402437.1 1406496 R 585055 CDS YP_002402438.1 218694771 7148338 1407596..1408234 1 NC_011748.1 receptor for colicin S4; outer membrane protein W 1408234 ompW 7148338 ompW Escherichia coli 55989 outer membrane protein W YP_002402438.1 1407596 D 585055 CDS YP_002402439.1 218694772 7147071 complement(1408280..1409410) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage integrase 1409410 7147071 EC55989_1355 Escherichia coli 55989 phage integrase YP_002402439.1 1408280 R 585055 CDS YP_002402440.1 218694773 7144546 complement(1409388..1409636) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage excisionase 1409636 7144546 EC55989_1356 Escherichia coli 55989 phage excisionase YP_002402440.1 1409388 R 585055 CDS YP_002402441.1 218694774 7144547 complement(1409701..1412172) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; exonuclease from phage origin 1412172 7144547 EC55989_1357 Escherichia coli 55989 exonuclease from phage origin YP_002402441.1 1409701 R 585055 CDS YP_002402442.1 218694775 7144548 complement(1412265..1412456) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage 1412456 ydfD 7144548 ydfD Escherichia coli 55989 Qin prophage YP_002402442.1 1412265 R 585055 CDS YP_002402443.1 218694776 7148432 complement(1412453..1412746) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; regulator of cell division encoded by prophage 1412746 7148432 EC55989_1359 Escherichia coli 55989 regulator of cell division encoded by prophage YP_002402443.1 1412453 R 585055 CDS YP_002402444.1 218694777 7145912 1412991..1413206 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1413206 7145912 EC55989_1360 Escherichia coli 55989 hypothetical protein YP_002402444.1 1412991 D 585055 CDS YP_002402445.1 218694778 7144550 1413136..1413402 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1413402 7144550 EC55989_1361 Escherichia coli 55989 hypothetical protein YP_002402445.1 1413136 D 585055 CDS YP_002402446.1 218694779 7144551 complement(1413391..1413741) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1413741 7144551 EC55989_1362 Escherichia coli 55989 hypothetical protein YP_002402446.1 1413391 R 585055 CDS YP_002402447.1 218694780 7144552 complement(1413741..1414049) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1414049 7144552 EC55989_1363 Escherichia coli 55989 hypothetical protein YP_002402447.1 1413741 R 585055 CDS YP_002402448.1 218694781 7144553 complement(1414086..1414544) 1 NC_011748.1 The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown.; transcriptional repressor DicA 1414544 dicA 7144553 dicA Escherichia coli 55989 transcriptional repressor DicA YP_002402448.1 1414086 R 585055 CDS YP_002402449.1 218694782 7145907 1414544..1414798 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA-binding transcriptional regulator DicC 1414798 7145907 EC55989_1365 Escherichia coli 55989 DNA-binding transcriptional regulator DicC YP_002402449.1 1414544 D 585055 CDS YP_002402450.1 218694783 7144554 1414782..1415303 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1415303 7144554 EC55989_1366 Escherichia coli 55989 hypothetical protein YP_002402450.1 1414782 D 585055 CDS YP_002402451.1 218694784 7144555 1415230..1416249 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1416249 7144555 EC55989_1367 Escherichia coli 55989 hypothetical protein YP_002402451.1 1415230 D 585055 CDS YP_002402452.1 218694785 7144556 1416290..1416712 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1416712 7144556 EC55989_1368 Escherichia coli 55989 phage protein YP_002402452.1 1416290 D 585055 CDS YP_002402453.1 218694786 7144557 1416965..1417864 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 1417864 7144557 EC55989_1369 Escherichia coli 55989 hypothetical protein YP_002402453.1 1416965 D 585055 CDS YP_002402454.1 218694787 7144558 complement(1418179..1418838) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; S-adenosyl-L-methionine-dependent methyltransferases 1418838 ymfD 7144558 ymfD Escherichia coli 55989 S-adenosyl-L-methionine-dependent methyltransferases YP_002402454.1 1418179 R 585055 CDS YP_002402455.1 218694788 7149274 complement(1418845..1419552) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1419552 7149274 EC55989_1371 Escherichia coli 55989 hypothetical protein YP_002402455.1 1418845 R 585055 CDS YP_002402456.1 218694789 7144559 complement(1419725..1419892) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 1419892 7144559 EC55989_1372 Escherichia coli 55989 hypothetical protein YP_002402456.1 1419725 R 585055 CDS YP_002402457.1 218694790 7144560 1420655..1420906 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2990907; Product type h : extrachromosomal origin; Qin prophage 1420906 rem 7144560 rem Escherichia coli 55989 Qin prophage YP_002402457.1 1420655 D 585055 CDS YP_002402458.1 218694791 7147371 1421253..1422302 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage 1422302 ydfU 7147371 ydfU Escherichia coli 55989 Qin prophage YP_002402458.1 1421253 D 585055 CDS YP_002402459.1 218694792 7148443 1422308..1422508 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1422508 7148443 EC55989_1375 Escherichia coli 55989 hypothetical protein YP_002402459.1 1422308 D 585055 CDS YP_002402460.1 218694793 7144561 1422315..1422674 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; crossover junction endodeoxyribonuclease rusA (Holliday junction nuclease rusA) (Holliday juction resolvase) (Gp67) 1422674 7144561 EC55989_1376 Escherichia coli 55989 crossover junction endodeoxyribonuclease rusA (Holliday junction nuclease rusA) (Holliday juction resolvase) (Gp67) YP_002402460.1 1422315 D 585055 CDS YP_002402461.1 218694794 7144562 1422665..1423360 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Antitermination protein Q 1423360 Q 7144562 Q Escherichia coli 55989 Antitermination protein Q YP_002402461.1 1422665 D 585055 CDS YP_002402462.1 218694795 7147326 1423432..1424271 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; protein kinase from phage origin 1424271 7147326 EC55989_1378 Escherichia coli 55989 protein kinase from phage origin YP_002402462.1 1423432 D 585055 CDS YP_002402463.1 218694796 7144563 1424268..1425011 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; protein phosphatase from phage origin 1425011 7144563 EC55989_1379 Escherichia coli 55989 protein phosphatase from phage origin YP_002402463.1 1424268 D 585055 CDS YP_002402464.1 218694797 7145327 1426724..1428580 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1428580 7145327 EC55989_1381 Escherichia coli 55989 hypothetical protein YP_002402464.1 1426724 D 585055 CDS YP_002402465.1 218694798 7144568 1429321..1429854 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane-associated lysozyme; Qin prophage 1429854 ydfQ 7144568 ydfQ Escherichia coli 55989 membrane-associated lysozyme; Qin prophage YP_002402465.1 1429321 D 585055 CDS YP_002402466.1 218694799 7148440 1429836..1430309 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2763468; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein Rz) 1430309 Rz 7148440 Rz Escherichia coli 55989 Endopeptidase (Lysis protein Rz) YP_002402466.1 1429836 D 585055 CDS YP_002402467.1 218694800 7147597 1430726..1431346 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage regulatory protein 1431346 7147597 EC55989_1386 Escherichia coli 55989 phage regulatory protein YP_002402467.1 1430726 D 585055 CDS YP_002402468.1 218694801 7144569 complement(1431288..1432355) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1432355 7144569 EC55989_1387 Escherichia coli 55989 hypothetical protein YP_002402468.1 1431288 R 585055 CDS YP_002402469.1 218694802 7144570 1432470..1432622 1 NC_011748.1 Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin; hypothetical protein 1432622 7144570 EC55989_1388 Escherichia coli 55989 hypothetical protein YP_002402469.1 1432470 D 585055 CDS YP_002402470.1 218694803 7144571 1432760..1433308 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Terminase small subunit (gp1) 1433308 7144571 EC55989_1389 Escherichia coli 55989 Terminase small subunit (gp1) YP_002402470.1 1432760 D 585055 CDS YP_002402471.1 218694804 7144572 1433238..1435208 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Terminase large subunit (Gp2) 1435208 7144572 EC55989_1390 Escherichia coli 55989 Terminase large subunit (Gp2) YP_002402471.1 1433238 D 585055 CDS YP_002402472.1 218694805 7144573 1435192..1435398 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Head stabilization protein (Head protein GP3) 1435398 7144573 EC55989_1391 Escherichia coli 55989 Head stabilization protein (Head protein GP3) YP_002402472.1 1435192 D 585055 CDS YP_002402473.1 218694806 7144574 1435395..1436987 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Portal protein (Head protein Gp4) 1436987 7144574 EC55989_1392 Escherichia coli 55989 Portal protein (Head protein Gp4) YP_002402473.1 1435395 D 585055 CDS YP_002402474.1 218694807 7144575 1436977..1438482 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Head-tail preconnector protein GP5 [Contains: Scaffold protein GP6 (Head protein GP6)] 1438482 7144575 EC55989_1393 Escherichia coli 55989 Head-tail preconnector protein GP5 [Contains: Scaffold protein GP6 (Head protein GP6)] YP_002402474.1 1436977 D 585055 CDS YP_002402475.1 218694808 7144576 1438519..1438866 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Head decoration protein (gpD) (Major capsid protein D) 1438866 7144576 EC55989_1394 Escherichia coli 55989 Head decoration protein (gpD) (Major capsid protein D) YP_002402475.1 1438519 D 585055 CDS YP_002402476.1 218694809 7144577 1438924..1439952 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major head protein (Head protein gp7) 1439952 7144577 EC55989_1395 Escherichia coli 55989 Major head protein (Head protein gp7) YP_002402476.1 1438924 D 585055 CDS YP_002402477.1 218694810 7144578 1439956..1440387 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1440387 7144578 EC55989_1396 Escherichia coli 55989 phage protein YP_002402477.1 1439956 D 585055 CDS YP_002402478.1 218694811 7144579 1440380..1440733 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail attachment protein (Minor capsid protein FII) 1440733 7144579 EC55989_1397 Escherichia coli 55989 Tail attachment protein (Minor capsid protein FII) YP_002402478.1 1440380 D 585055 CDS YP_002402479.1 218694812 7144580 1440748..1441323 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein Z (GpZ) 1441323 7144580 EC55989_1398 Escherichia coli 55989 Minor tail protein Z (GpZ) YP_002402479.1 1440748 D 585055 CDS YP_002402480.1 218694813 7144581 1441320..1441715 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein U 1441715 7144581 EC55989_1399 Escherichia coli 55989 Minor tail protein U YP_002402480.1 1441320 D 585055 CDS YP_002402481.1 218694814 7144582 1441723..1442475 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail protein V 1442475 7144582 EC55989_1400 Escherichia coli 55989 Major tail protein V YP_002402481.1 1441723 D 585055 CDS YP_002402482.1 218694815 7144583 1442489..1442920 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein G 1442920 7144583 EC55989_1401 Escherichia coli 55989 Minor tail protein G YP_002402482.1 1442489 D 585055 CDS YP_002402483.1 218694816 7144584 1442947..1443360 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein T 1443360 7144584 EC55989_1402 Escherichia coli 55989 Minor tail protein T YP_002402483.1 1442947 D 585055 CDS YP_002402484.1 218694817 7144585 1443341..1445914 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein precursor H 1445914 7144585 EC55989_1403 Escherichia coli 55989 Minor tail protein precursor H YP_002402484.1 1443341 D 585055 CDS YP_002402485.1 218694818 7144586 1445911..1446240 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein M 1446240 7144586 EC55989_1405 Escherichia coli 55989 Minor tail protein M YP_002402485.1 1445911 D 585055 CDS YP_002402486.1 218694819 7144587 1446240..1446938 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein L 1446938 7144587 EC55989_1406 Escherichia coli 55989 Minor tail protein L YP_002402486.1 1446240 D 585055 CDS YP_002402487.1 218694820 7144588 1446688..1447692 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber component K 1447692 7144588 EC55989_1407 Escherichia coli 55989 tail fiber component K YP_002402487.1 1446688 D 585055 CDS YP_002402488.1 218694821 7144589 1447590..1448270 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail assembly protein I 1448270 7144589 EC55989_1408 Escherichia coli 55989 Tail assembly protein I YP_002402488.1 1447590 D 585055 CDS YP_002402489.1 218694822 7144590 1448613..1452086 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J 1452086 7144590 EC55989_1409 Escherichia coli 55989 Host specificity protein J YP_002402489.1 1448613 D 585055 CDS YP_002402490.1 218694823 7144591 1452154..1452753 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; Lom-like outer membrane protein of phage origin 1452753 7144591 EC55989_1410 Escherichia coli 55989 Lom-like outer membrane protein of phage origin YP_002402490.1 1452154 D 585055 CDS YP_002402491.1 218694824 7144592 1452905..1456075 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber protein 1456075 7144592 EC55989_1411 Escherichia coli 55989 tail fiber protein YP_002402491.1 1452905 D 585055 CDS YP_002402492.1 218694825 7144593 1456075..1456659 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; tail fiber chaperone; Qin prophage 1456659 tfaQ 7144593 tfaQ Escherichia coli 55989 tail fiber chaperone; Qin prophage YP_002402492.1 1456075 D 585055 CDS YP_002402493.1 218694826 7147778 complement(1456714..1457298) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; AdoMet-dependent methyltransferase; DLP12 prophage 1457298 ybcY 7147778 ybcY Escherichia coli 55989 AdoMet-dependent methyltransferase; DLP12 prophage YP_002402493.1 1456714 R 585055 CDS YP_002402494.1 218694827 7148137 1457439..1457708 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber assembly protein 1457708 7148137 EC55989_1414 Escherichia coli 55989 tail fiber assembly protein YP_002402494.1 1457439 D 585055 CDS YP_002402495.1 218694828 7144594 complement(1458482..1458988) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15388941, 3058546, 8455549; hypothetical protein 1458988 yciE 7144594 yciE Escherichia coli 55989 hypothetical protein YP_002402495.1 1458482 R 585055 CDS YP_002402496.1 218694829 7148339 complement(1459034..1459534) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3058546, 8455549; hypothetical protein 1459534 yciF 7148339 yciF Escherichia coli 55989 hypothetical protein YP_002402496.1 1459034 R 585055 CDS YP_002402497.1 218694830 7148341 complement(1459620..1459799) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1459799 yciG 7148341 yciG Escherichia coli 55989 hypothetical protein YP_002402497.1 1459620 R 585055 CDS YP_002402498.1 218694831 7148343 complement(1460180..1460986) 1 NC_011748.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha 1460986 trpA 7148343 trpA Escherichia coli 55989 tryptophan synthase subunit alpha YP_002402498.1 1460180 R 585055 CDS YP_002402499.1 218694832 7147850 complement(1460986..1462179) 1 NC_011748.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta 1462179 trpB 7147850 trpB Escherichia coli 55989 tryptophan synthase subunit beta YP_002402499.1 1460986 R 585055 CDS YP_002402500.1 218694833 7147851 complement(1462191..1463549) 1 NC_011748.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase 1463549 trpC 7147851 trpC Escherichia coli 55989 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase YP_002402500.1 1462191 R 585055 CDS YP_002402501.1 218694834 7147852 complement(1463553..1465148) 1 NC_011748.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase 1465148 trpD 7147852 trpD Escherichia coli 55989 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase YP_002402501.1 1463553 R 585055 CDS YP_002402502.1 218694835 7147853 complement(1465148..1466710) 1 NC_011748.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I 1466710 trpE 7147853 trpE Escherichia coli 55989 anthranilate synthase component I YP_002402502.1 1465148 R 585055 CDS YP_002402504.1 218694837 7147855 1466984..1467865 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1467865 yciV 7147855 yciV Escherichia coli 55989 hypothetical protein YP_002402504.1 1466984 D 585055 CDS YP_002402505.1 218694838 7148353 1467862..1468482 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1468482 yciO 7148353 yciO Escherichia coli 55989 hypothetical protein YP_002402505.1 1467862 D 585055 CDS YP_002402506.1 218694839 7148350 1468556..1469455 1 NC_011748.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1469455 rluB 7148350 rluB Escherichia coli 55989 23S rRNA pseudouridylate synthase B YP_002402506.1 1468556 D 585055 CDS YP_002402507.1 218694840 7147427 complement(1469495..1470085) 1 NC_011748.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase 1470085 btuR 7147427 btuR Escherichia coli 55989 cob(I)yrinic acid a,c-diamide adenosyltransferase YP_002402507.1 1469495 R 585055 CDS YP_002402508.1 218694841 7145644 complement(1470082..1470840) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; short chain dehydrogenase 1470840 yciK 7145644 yciK Escherichia coli 55989 short chain dehydrogenase YP_002402508.1 1470082 R 585055 CDS YP_002402509.1 218694842 7148347 complement(1470884..1471048) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1471048 7148347 EC55989_1428 Escherichia coli 55989 hypothetical protein YP_002402509.1 1470884 R 585055 CDS YP_002402510.1 218694843 7144595 1471060..1472109 1 NC_011748.1 SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 1472109 sohB 7144595 sohB Escherichia coli 55989 periplasmic protease YP_002402510.1 1471060 D 585055 CDS YP_002402511.1 218694844 7147675 complement(1472145..1472396) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029379, 7567469, 9868784; hypothetical protein 1472396 yciN 7147675 yciN Escherichia coli 55989 hypothetical protein YP_002402511.1 1472145 R 585055 CDS YP_002402512.1 218694845 7148349 1472441..1472653 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1472653 7148349 EC55989_1431 Escherichia coli 55989 hypothetical protein YP_002402512.1 1472441 D 585055 CDS YP_002402513.1 218694846 7144596 1472776..1475373 1 NC_011748.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1475373 topA 7144596 topA Escherichia coli 55989 DNA topoisomerase I YP_002402513.1 1472776 D 585055 CDS YP_002402514.1 218694847 7147818 1475583..1476557 1 NC_011748.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1476557 cysB 7147818 cysB Escherichia coli 55989 transcriptional regulator CysB YP_002402514.1 1475583 D 585055 CDS YP_002402515.1 218694848 7145821 1476851..1477015 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1477015 7145821 EC55989_1434 Escherichia coli 55989 hypothetical protein YP_002402515.1 1476851 D 585055 CDS YP_002402516.1 218694849 7144597 1476997..1477185 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1477185 7144597 EC55989_1435 Escherichia coli 55989 hypothetical protein YP_002402516.1 1476997 D 585055 CDS YP_002402517.1 218694850 7144598 1477322..1477504 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1477504 7144598 EC55989_1436 Escherichia coli 55989 hypothetical protein YP_002402517.1 1477322 D 585055 CDS YP_002402518.1 218694851 7144599 1477558..1480233 1 NC_011748.1 Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1480233 acnA 7144599 acnA Escherichia coli 55989 aconitate hydratase YP_002402518.1 1477558 D 585055 CDS YP_002402519.1 218694852 7145438 complement(1480297..1480887) 1 NC_011748.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II 1480887 ribA 7145438 ribA Escherichia coli 55989 GTP cyclohydrolase II YP_002402519.1 1480297 R 585055 CDS YP_002402520.1 218694853 7147409 1481057..1481821 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033893, 92104964; Product type e : enzyme; phosphatidylglycerophosphatase B 1481821 pgpB 7147409 pgpB Escherichia coli 55989 phosphatidylglycerophosphatase B YP_002402520.1 1481057 D 585055 CDS YP_002402521.1 218694854 7147155 1481970..1482278 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1482278 yciS 7147155 yciS Escherichia coli 55989 inner membrane protein YP_002402521.1 1481970 D 585055 CDS YP_002402522.1 218694855 7148351 1482285..1483454 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; tetratricopeptide repeat protein 1483454 yciM 7148351 yciM Escherichia coli 55989 tetratricopeptide repeat protein YP_002402522.1 1482285 D 585055 CDS YP_002402523.1 218694856 7148348 1483647..1484384 1 NC_011748.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1484384 pyrF 7148348 pyrF Escherichia coli 55989 orotidine 5'-phosphate decarboxylase YP_002402523.1 1483647 D 585055 CDS YP_002402524.1 218694857 7147321 1484384..1484710 1 NC_011748.1 involved in start site selection during the initiation of translation; translation initiation factor Sui1 1484710 yciH 7147321 yciH Escherichia coli 55989 translation initiation factor Sui1 YP_002402524.1 1484384 D 585055 CDS YP_002402525.1 218694858 7148345 complement(1484836..1485054) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 2644204; Product type lp : lipoprotein; lipoprotein 1485054 osmB 7148345 osmB Escherichia coli 55989 lipoprotein YP_002402525.1 1484836 R 585055 CDS YP_002402526.1 218694859 7147081 complement(1485323..1486072) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16451192; Product type r : regulator; DNA-binding transcriptional repressor, DeoR family 1486072 deoT 7147081 deoT Escherichia coli 55989 DNA-binding transcriptional repressor, DeoR family YP_002402526.1 1485323 R 585055 CDS YP_002402527.1 218694860 7145891 complement(1486162..1486377) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1486377 7145891 EC55989_1446 Escherichia coli 55989 hypothetical protein YP_002402527.1 1486162 R 585055 CDS YP_002402528.1 218694861 7144600 complement(1486482..1488467) 1 NC_011748.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator 1488467 gmr 7144600 gmr Escherichia coli 55989 RNase II stability modulator YP_002402528.1 1486482 R 585055 CDS YP_002402529.1 218694862 7146345 complement(1488702..1490636) 1 NC_011748.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II 1490636 rnb 7146345 rnb Escherichia coli 55989 exoribonuclease II YP_002402529.1 1488702 R 585055 CDS YP_002402530.1 218694863 7147444 complement(1490704..1491831) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; amidase 1491831 yciW 7147444 yciW Escherichia coli 55989 amidase YP_002402530.1 1490704 R 585055 CDS YP_002402531.1 218694864 7148354 complement(1491976..1492764) 1 NC_011748.1 Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase 1492764 fabI 7148354 fabI Escherichia coli 55989 enoyl-(acyl carrier protein) reductase YP_002402531.1 1491976 R 585055 CDS YP_002402532.1 218694865 7146052 complement(1493134..1493487) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1493487 ycjD 7146052 ycjD Escherichia coli 55989 hypothetical protein YP_002402532.1 1493134 R 585055 CDS YP_002402533.1 218694866 7148355 complement(1493555..1494361) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580; Product type t : transporter; antimicrobial peptide transporter subunit ; ATP-binding component of ABC superfamily transporter 1494361 sapF 7148355 sapF Escherichia coli 55989 antimicrobial peptide transporter subunit ; ATP-binding component of ABC superfamily transporter YP_002402533.1 1493555 R 585055 CDS YP_002402534.1 218694867 7147605 complement(1494363..1495355) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580, 1987159; Product type t : transporter; antimicrobial peptide transporter subunit; ATP-binding component of ABC superfamily transporter 1495355 sapD 7147605 sapD Escherichia coli 55989 antimicrobial peptide transporter subunit; ATP-binding component of ABC superfamily transporter YP_002402534.1 1494363 R 585055 CDS YP_002402535.1 218694868 7147604 complement(1495355..1496245) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide transporter subunit ; permease component of ABC superfamily transporter 1496245 sapC 7147604 sapC Escherichia coli 55989 antimicrobial peptide transporter subunit ; permease component of ABC superfamily transporter YP_002402535.1 1495355 R 585055 CDS YP_002402536.1 218694869 7147603 complement(1496232..1497197) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide transporter subunit ; permease component of ABC superfamily transporter 1497197 sapB 7147603 sapB Escherichia coli 55989 antimicrobial peptide transporter subunit ; permease component of ABC superfamily transporter YP_002402536.1 1496232 R 585055 CDS YP_002402537.1 218694870 7147602 complement(1497194..1498837) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide transporter subunit; periplasmic-binding component of ABC superfamily transporter 1498837 sapA 7147602 sapA Escherichia coli 55989 antimicrobial peptide transporter subunit; periplasmic-binding component of ABC superfamily transporter YP_002402537.1 1497194 R 585055 CDS YP_002402538.1 218694871 7147601 complement(1499149..1499394) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1499394 ymjA 7147601 ymjA Escherichia coli 55989 hypothetical protein YP_002402538.1 1499149 R 585055 CDS YP_002402539.1 218694872 7149282 complement(1499528..1500913) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15590624; Product type t : transporter; putrescine importer 1500913 puuP 7149282 puuP Escherichia coli 55989 putrescine importer YP_002402539.1 1499528 R 585055 CDS YP_002402540.1 218694873 7147313 complement(1501216..1502634) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15590624; Product type e : enzyme; gamma-Glu-putrescine synthase 1502634 puuA 7147313 puuA Escherichia coli 55989 gamma-Glu-putrescine synthase YP_002402540.1 1501216 R 585055 CDS YP_002402541.1 218694874 7147308 1502846..1503610 1 NC_011748.1 catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 1503610 puuD 7147308 puuD Escherichia coli 55989 gamma-glutamyl-gamma-aminobutyrate hydrolase YP_002402541.1 1502846 D 585055 CDS YP_002402542.1 218694875 7147311 1503637..1504194 1 NC_011748.1 regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1504194 puuR 7147311 puuR Escherichia coli 55989 DNA-binding transcriptional repressor PuuR YP_002402542.1 1503637 D 585055 CDS YP_002402543.1 218694876 7147314 1504469..1505956 1 NC_011748.1 catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1505956 puuC 7147314 puuC Escherichia coli 55989 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase YP_002402543.1 1504469 D 585055 CDS YP_002402544.1 218694877 7147310 1505958..1507238 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150200, 15590624; Product type e : enzyme; gamma-Glu-putrescine oxidase 1507238 puuB 7147310 puuB Escherichia coli 55989 gamma-Glu-putrescine oxidase YP_002402544.1 1505958 D 585055 CDS YP_002402545.1 218694878 7147309 1507276..1508541 1 NC_011748.1 putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 1508541 puuE 7147309 puuE Escherichia coli 55989 4-aminobutyrate aminotransferase YP_002402545.1 1507276 D 585055 CDS YP_002402546.1 218694879 7147312 complement(1508661..1509638) 1 NC_011748.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator 1509638 pspF 7147312 pspF Escherichia coli 55989 phage shock protein operon transcriptional activator YP_002402546.1 1508661 R 585055 CDS YP_002402547.1 218694880 7147275 1509805..1510473 1 NC_011748.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1510473 pspA 7147275 pspA Escherichia coli 55989 phage shock protein PspA YP_002402547.1 1509805 D 585055 CDS YP_002402548.1 218694881 7147270 1510527..1510751 1 NC_011748.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1510751 pspB 7147270 pspB Escherichia coli 55989 phage shock protein B YP_002402548.1 1510527 D 585055 CDS YP_002402549.1 218694882 7147271 1510751..1511110 1 NC_011748.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1511110 pspC 7147271 pspC Escherichia coli 55989 DNA-binding transcriptional activator PspC YP_002402549.1 1510751 D 585055 CDS YP_002402550.1 218694883 7147272 1511119..1511340 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295203, 97303082; Product type ph : phenotype; peripheral inner membrane phage-shock protein 1511340 pspD 7147272 pspD Escherichia coli 55989 peripheral inner membrane phage-shock protein YP_002402550.1 1511119 D 585055 CDS YP_002402551.1 218694884 7147273 1511415..1511729 1 NC_011748.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1511729 pspE 7147273 pspE Escherichia coli 55989 thiosulfate:cyanide sulfurtransferase YP_002402551.1 1511415 D 585055 CDS YP_002402552.1 218694885 7147274 1511941..1513620 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; glucosyltransferase 1513620 ycjM 7147274 ycjM Escherichia coli 55989 glucosyltransferase YP_002402552.1 1511941 D 585055 CDS YP_002402553.1 218694886 7148358 1513634..1514926 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sugar transporter subunit: periplasmic-binding component of ABC superfamily transporter 1514926 ycjN 7148358 ycjN Escherichia coli 55989 sugar transporter subunit: periplasmic-binding component of ABC superfamily transporter YP_002402553.1 1513634 D 585055 CDS YP_002402554.1 218694887 7148359 1514947..1515828 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sugar transporter subunit: permease component of ABC superfamily transporter 1515828 ycjO 7148359 ycjO Escherichia coli 55989 sugar transporter subunit: permease component of ABC superfamily transporter YP_002402554.1 1514947 D 585055 CDS YP_002402555.1 218694888 7148360 1515815..1516657 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sugar transporter subunit: permease component of ABC superfamily transporter 1516657 ycjP 7148360 ycjP Escherichia coli 55989 sugar transporter subunit: permease component of ABC superfamily transporter YP_002402555.1 1515815 D 585055 CDS YP_002402556.1 218694889 7148361 1516688..1517740 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase, Zn-dependent and NAD(P)-binding 1517740 ycjQ 7148361 ycjQ Escherichia coli 55989 oxidoreductase, Zn-dependent and NAD(P)-binding YP_002402556.1 1516688 D 585055 CDS YP_002402557.1 218694890 7148362 1517758..1518546 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; isomerase/epimerase 1518546 ycjR 7148362 ycjR Escherichia coli 55989 isomerase/epimerase YP_002402557.1 1517758 D 585055 CDS YP_002402558.1 218694891 7148365 1519608..1521875 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; glycosyl hydrolase/phosphorylase 1521875 ycjT 7148365 ycjT Escherichia coli 55989 glycosyl hydrolase/phosphorylase YP_002402558.1 1519608 D 585055 CDS YP_002402559.1 218694892 7148366 1521872..1522531 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11972617; Product type pe : enzyme; glucose-1-phosphate phosphodismutase, beta-phosphoglucomutase 1522531 ycjU 7148366 ycjU Escherichia coli 55989 glucose-1-phosphate phosphodismutase, beta-phosphoglucomutase YP_002402559.1 1521872 D 585055 CDS YP_002402560.1 218694893 7148367 1522545..1523627 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sugar transporter subunit: ATP-binding component of ABC superfamily transporter 1523627 ycjV 7148367 ycjV Escherichia coli 55989 sugar transporter subunit: ATP-binding component of ABC superfamily transporter YP_002402560.1 1522545 D 585055 CDS YP_002402561.1 218694894 7148368 1523672..1524577 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20464934, 89327119, 9721282; Product type t : transporter; outer membrane porin 1524577 ompG 7148368 ompG Escherichia coli 55989 outer membrane porin YP_002402561.1 1523672 D 585055 CDS YP_002402562.1 218694895 7147068 complement(1524688..1525686) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1525686 ycjW 7147068 ycjW Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402562.1 1524688 R 585055 CDS YP_002402563.1 218694896 7148369 1525841..1527238 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; nucleoside triphosphate hydrolase domain 1527238 ycjX 7148369 ycjX Escherichia coli 55989 nucleoside triphosphate hydrolase domain YP_002402563.1 1525841 D 585055 CDS YP_002402564.1 218694897 7148370 1527235..1528296 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 1528296 ycjF 7148370 ycjF Escherichia coli 55989 hypothetical protein YP_002402564.1 1527235 D 585055 CDS YP_002402565.1 218694898 7148356 1528444..1529985 1 NC_011748.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1529985 tyrR 7148356 tyrR Escherichia coli 55989 DNA-binding transcriptional regulator TyrR YP_002402565.1 1528444 D 585055 CDS YP_002402566.1 218694899 7147884 complement(1530029..1530535) 1 NC_011748.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase 1530535 tpx 7147884 tpx Escherichia coli 55989 thiol peroxidase YP_002402566.1 1530029 R 585055 CDS YP_002402567.1 218694900 7147833 1530654..1531619 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11747447, 11747448, 7499381; Product type e : enzyme; L-Ala-D/L-Glu epimerase 1531619 ycjG 7147833 ycjG Escherichia coli 55989 L-Ala-D/L-Glu epimerase YP_002402567.1 1530654 D 585055 CDS YP_002402568.1 218694901 7148357 complement(1531594..1532382) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12511517; Product type e : enzyme; murein peptide amidase A 1532382 mpaA 7148357 mpaA Escherichia coli 55989 murein peptide amidase A YP_002402568.1 1531594 R 585055 CDS YP_002402569.1 218694902 7149283 complement(1532658..1533590) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase 1533590 ycjY 7149283 ycjY Escherichia coli 55989 hydrolase YP_002402569.1 1532658 R 585055 CDS YP_002402570.1 218694903 7148371 1533716..1534615 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pr : regulator; nucleic acid-binding regulator 1534615 ycjZ 7148371 ycjZ Escherichia coli 55989 nucleic acid-binding regulator YP_002402570.1 1533716 D 585055 CDS YP_002402571.1 218694904 7148372 1534952..1536565 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438753, 9495761; Product type t : transporter; murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit ; periplasmic-binding component of ABC superfamily 1536565 mppA 7148372 mppA Escherichia coli 55989 murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit ; periplasmic-binding component of ABC superfamily YP_002402571.1 1534952 D 585055 CDS YP_002402572.1 218694905 7146892 complement(1536616..1537647) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1537647 ynaI 7146892 ynaI Escherichia coli 55989 inner membrane protein YP_002402572.1 1536616 R 585055 CDS YP_002402573.1 218694906 7149284 1537891..1538148 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1538148 ynaJ 7149284 ynaJ Escherichia coli 55989 inner membrane protein YP_002402573.1 1537891 D 585055 CDS YP_002402574.1 218694907 7149285 complement(1538198..1539148) 1 NC_011748.1 with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE 1539148 uspE 7149285 uspE Escherichia coli 55989 universal stress protein UspE YP_002402574.1 1538198 R 585055 CDS YP_002402575.1 218694908 7147929 complement(1539300..1540052) 1 NC_011748.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator 1540052 fnr 7147929 fnr Escherichia coli 55989 fumarate/nitrate reduction transcriptional regulator YP_002402575.1 1539300 R 585055 CDS YP_002402576.1 218694909 7146165 complement(1540247..1540762) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88067749, 91161525, 94252990, 98125595, 1520330; Product type e : enzyme; O-6-alkylguanine-DNA:cysteine-protein methyltransferase 1540762 ogt 7146165 ogt Escherichia coli 55989 O-6-alkylguanine-DNA:cysteine-protein methyltransferase YP_002402576.1 1540247 R 585055 CDS YP_002402577.1 218694910 7147064 complement(1540773..1542299) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9829935, 2825131, 7567469; Product type t : transporter; aminobenzoyl-glutamate transporter 1542299 abgT 7147064 abgT Escherichia coli 55989 aminobenzoyl-glutamate transporter YP_002402577.1 1540773 R 585055 CDS YP_002402578.1 218694911 7145426 complement(1542229..1542423) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1542423 7145426 EC55989_1501 Escherichia coli 55989 hypothetical protein YP_002402578.1 1542229 R 585055 CDS YP_002402579.1 218694912 7144601 complement(1542336..1543781) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9829935; Product type pe : enzyme; peptidase, aminobenzoyl-glutamate utilization protein 1543781 abgB 7144601 abgB Escherichia coli 55989 peptidase, aminobenzoyl-glutamate utilization protein YP_002402579.1 1542336 R 585055 CDS YP_002402580.1 218694913 7145424 complement(1543781..1545091) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9829935; Product type pe : enzyme; peptidase, para-aminobenzoyl-glutamate utilization protein 1545091 abgA 7145424 abgA Escherichia coli 55989 peptidase, para-aminobenzoyl-glutamate utilization protein YP_002402580.1 1543781 R 585055 CDS YP_002402581.1 218694914 7145423 1545267..1546175 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9829935; Product type r : regulator; DNA-binding transcriptional regulator 1546175 abgR 7145423 abgR Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402581.1 1545267 D 585055 CDS YP_002402582.1 218694915 7146633 1546505..1547068 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1547068 ydaL 7146633 ydaL Escherichia coli 55989 hypothetical protein YP_002402582.1 1546505 D 585055 CDS YP_002402583.1 218694916 7148373 complement(1547089..1548321) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16045609; Product type pe : enzyme; diguanylate cyclase, GG[D/E]EF domain signalling protein 1548321 ydaM 7148373 ydaM Escherichia coli 55989 diguanylate cyclase, GG[D/E]EF domain signalling protein YP_002402583.1 1547089 R 585055 CDS YP_002402584.1 218694917 7148374 1548576..1549559 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; zinc transporter 1549559 zntB 7148374 zntB Escherichia coli 55989 zinc transporter YP_002402584.1 1548576 D 585055 CDS YP_002402585.1 218694918 7148375 1549834..1550007 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1550007 7148375 EC55989_1508 Escherichia coli 55989 hypothetical protein YP_002402585.1 1549834 D 585055 CDS YP_002402586.1 218694919 7145649 1550037..1551410 1 NC_011748.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1551410 dbpA 7145649 dbpA Escherichia coli 55989 ATP-dependent RNA helicase DbpA YP_002402586.1 1550037 D 585055 CDS YP_002402587.1 218694920 7145854 complement(1551539..1552474) 1 NC_011748.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase 1552474 ydaO 7145854 ydaO Escherichia coli 55989 C32 tRNA thiolase YP_002402587.1 1551539 R 585055 CDS YP_002402588.1 218694921 7148376 complement(1552650..1553084) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12381839, 11849540, 9298646; Product type f : factor; stress-induced protein, ATP-binding protein 1553084 uspF 7148376 uspF Escherichia coli 55989 stress-induced protein, ATP-binding protein YP_002402588.1 1552650 R 585055 CDS YP_002402589.1 218694922 7147930 complement(1553225..1554358) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642192; Product type t : transporter; outer membrane pore protein N, non-specific 1554358 ompN 7147930 ompN Escherichia coli 55989 outer membrane pore protein N, non-specific YP_002402589.1 1553225 R 585055 CDS YP_002402590.1 218694923 7146855 complement(1554725..1558249) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9025293; Product type pe : enzyme; 2-oxoacid-flavodoxin fused oxidoreductase:conserved protein; 4Fe-4S cluster binding protein 1558249 ydbK 7146855 ydbK Escherichia coli 55989 2-oxoacid-flavodoxin fused oxidoreductase:conserved protein; 4Fe-4S cluster binding protein YP_002402590.1 1554725 R 585055 CDS YP_002402591.1 218694924 7148381 1558523..1558789 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1558789 ydbJ 7148381 ydbJ Escherichia coli 55989 hypothetical protein YP_002402591.1 1558523 D 585055 CDS YP_002402592.1 218694925 7148380 complement(1558786..1559208) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12892888, 8349564, 9025293; Product type f : factor; heat-inducible protein 1559208 hslJ 7148380 hslJ Escherichia coli 55989 heat-inducible protein YP_002402592.1 1558786 R 585055 CDS YP_002402593.1 218694926 7146467 complement(1559319..1560308) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4297266, 89123040, 90198524, 8349564, 9025293; Product type e : enzyme; fermentative D-lactate dehydrogenase, NAD-dependent 1560308 ldhA 7146467 ldhA Escherichia coli 55989 fermentative D-lactate dehydrogenase, NAD-dependent YP_002402593.1 1559319 R 585055 CDS YP_002402594.1 218694927 7146682 1560516..1563155 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1563155 ydbH 7146682 ydbH Escherichia coli 55989 hypothetical protein YP_002402594.1 1560516 D 585055 CDS YP_002402595.1 218694928 7148379 1563152..1563337 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; lipoprotein 1563337 ynbE 7148379 ynbE Escherichia coli 55989 lipoprotein YP_002402595.1 1563152 D 585055 CDS YP_002402596.1 218694929 7149290 1563345..1563671 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1563671 ydbL 7149290 ydbL Escherichia coli 55989 hypothetical protein YP_002402596.1 1563345 D 585055 CDS YP_002402597.1 218694930 7148382 complement(1563843..1564748) 1 NC_011748.1 activator of genes involved in phenylacetic acid catabolism; DNA-binding transcriptional activator FeaR 1564748 feaR 7148382 feaR Escherichia coli 55989 DNA-binding transcriptional activator FeaR YP_002402597.1 1563843 R 585055 CDS YP_002402598.1 218694931 7146078 1564984..1566483 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96213037, 97263463, 9043126; Product type e : enzyme; phenylacetaldehyde dehydrogenase 1566483 feaB 7146078 feaB Escherichia coli 55989 phenylacetaldehyde dehydrogenase YP_002402598.1 1564984 D 585055 CDS YP_002402599.1 218694932 7146077 complement(1566541..1568814) 1 NC_011748.1 catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine; tyramine oxidase 1568814 tynA 7146077 tynA Escherichia coli 55989 tyramine oxidase YP_002402599.1 1566541 R 585055 CDS YP_002402600.1 218694933 7147880 complement(1569062..1571107) 1 NC_011748.1 catalyzes the ring cleavage reaction in phenylacetate degradation and the formation of 3-hydroxyacyl-CoA from crotonyl-CoA; bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase 1571107 maoC 7147880 maoC Escherichia coli 55989 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase YP_002402600.1 1569062 R 585055 CDS YP_002402601.1 218694934 7146785 1571392..1572321 1 NC_011748.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; phenylacetate-CoA oxygenase subunit PaaA 1572321 paaA 7146785 paaA Escherichia coli 55989 phenylacetate-CoA oxygenase subunit PaaA YP_002402601.1 1571392 D 585055 CDS YP_002402602.1 218694935 7147093 1572333..1572620 1 NC_011748.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation; phenylacetate-CoA oxygenase subunit PaaB 1572620 paaB 7147093 paaB Escherichia coli 55989 phenylacetate-CoA oxygenase subunit PaaB YP_002402602.1 1572333 D 585055 CDS YP_002402603.1 218694936 7147094 1572629..1573375 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : enzyme; multicomponent oxygenase/reductase subunit for phenylacetic acid degradation 1573375 paaC 7147094 paaC Escherichia coli 55989 multicomponent oxygenase/reductase subunit for phenylacetic acid degradation YP_002402603.1 1572629 D 585055 CDS YP_002402604.1 218694937 7147095 1573390..1573887 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : enzyme; multicomponent oxygenase/reductase subunit for phenylacetic acid degradation 1573887 paaD 7147095 paaD Escherichia coli 55989 multicomponent oxygenase/reductase subunit for phenylacetic acid degradation YP_002402604.1 1573390 D 585055 CDS YP_002402605.1 218694938 7147096 1573895..1574965 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17259607, 11260461, 12846838, 9748275; Product type e : enzyme; subunit of the phenylacetly-CoA oxygenase/reductase 1574965 paaJ 7147096 paaJ Escherichia coli 55989 subunit of the phenylacetly-CoA oxygenase/reductase YP_002402605.1 1573895 D 585055 CDS YP_002402606.1 218694939 7147102 1574962..1575729 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 9748275, 10766858; Product type e : enzyme; enoyl-CoA hydratase-isomerase 1575729 paaF 7147102 paaF Escherichia coli 55989 enoyl-CoA hydratase-isomerase YP_002402606.1 1574962 D 585055 CDS YP_002402607.1 218694940 7147098 1575729..1576517 1 NC_011748.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1576517 paaG 7147098 paaG Escherichia coli 55989 enoyl-CoA hydratase YP_002402607.1 1575729 D 585055 CDS YP_002402608.1 218694941 7147099 1576519..1577946 1 NC_011748.1 converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation; 3-hydroxyacyl-CoA dehydrogenase 1577946 paaH 7147099 paaH Escherichia coli 55989 3-hydroxyacyl-CoA dehydrogenase YP_002402608.1 1576519 D 585055 CDS YP_002402609.1 218694942 7147100 1577936..1578358 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16464851, 12846838, 9748275; Product type e : enzyme; phenylacetate pathway hotdog-fold thioesterase 1578358 paaI 7147100 paaI Escherichia coli 55989 phenylacetate pathway hotdog-fold thioesterase YP_002402609.1 1577936 D 585055 CDS YP_002402610.1 218694943 7147101 1578358..1579563 1 NC_011748.1 catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA; beta-ketoadipyl CoA thiolase 1579563 paaE 7147101 paaE Escherichia coli 55989 beta-ketoadipyl CoA thiolase YP_002402610.1 1578358 D 585055 CDS YP_002402611.1 218694944 7147097 1579590..1580903 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 9748275, 10766858; Product type e : enzyme; phenylacetyl-CoA ligase 1580903 paaK 7147097 paaK Escherichia coli 55989 phenylacetyl-CoA ligase YP_002402611.1 1579590 D 585055 CDS YP_002402612.1 218694945 7147103 1581004..1581954 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 20229831, 9748275; Product type r : regulator; DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive 1581954 paaX 7147103 paaX Escherichia coli 55989 DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive YP_002402612.1 1581004 D 585055 CDS YP_002402613.1 218694946 7147104 1581936..1582526 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : enzyme; hexapeptide repeat acetyltransferase 1582526 paaY 7147104 paaY Escherichia coli 55989 hexapeptide repeat acetyltransferase YP_002402613.1 1581936 D 585055 CDS YP_002402614.1 218694947 7147105 1582756..1583616 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase 1583616 ydbC 7147105 ydbC Escherichia coli 55989 oxidoreductase YP_002402614.1 1582756 D 585055 CDS YP_002402615.1 218694948 7148377 1583680..1585986 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1585986 ydbD 7148377 ydbD Escherichia coli 55989 hypothetical protein YP_002402615.1 1583680 D 585055 CDS YP_002402616.1 218694949 7148378 1586157..1586762 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1586762 ynbA 7148378 ynbA Escherichia coli 55989 inner membrane protein YP_002402616.1 1586157 D 585055 CDS YP_002402617.1 218694950 7149286 1586762..1587658 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane associated CTP-phosphosubstrate transferase 1587658 ynbB 7149286 ynbB Escherichia coli 55989 membrane associated CTP-phosphosubstrate transferase YP_002402617.1 1586762 D 585055 CDS YP_002402618.1 218694951 7149287 1587674..1589431 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase 1589431 ynbC 7149287 ynbC Escherichia coli 55989 hydrolase YP_002402618.1 1587674 D 585055 CDS YP_002402619.1 218694952 7149288 1589445..1590737 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane associated phosphatase 1590737 ynbD 7149288 ynbD Escherichia coli 55989 membrane associated phosphatase YP_002402619.1 1589445 D 585055 CDS YP_002402620.1 218694953 7149289 complement(1590788..1591393) 1 NC_011748.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase 1591393 azoR 7149289 azoR Escherichia coli 55989 azoreductase YP_002402620.1 1590788 R 585055 CDS YP_002402621.1 218694954 7145590 1591651..1595496 1 NC_011748.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1595496 hrpA 7145590 hrpA Escherichia coli 55989 ATP-dependent RNA helicase HrpA YP_002402621.1 1591651 D 585055 CDS YP_002402622.1 218694955 7146459 1595768..1596568 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1596568 ydcF 7146459 ydcF Escherichia coli 55989 hypothetical protein YP_002402622.1 1595768 D 585055 CDS YP_002402623.1 218694956 7148385 1596765..1598204 1 NC_011748.1 NAD-linked; aldehyde dehydrogenase 1598204 aldA 7148385 aldA Escherichia coli 55989 aldehyde dehydrogenase YP_002402623.1 1596765 D 585055 CDS YP_002402624.1 218694957 7145479 complement(1598246..1599247) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9622357, 9019141, 1917845, 3780374; Product type e : enzyme; glyceraldehyde-3-phosphate dehydrogenase 1599247 gapC 7145479 gapC Escherichia coli 55989 glyceraldehyde-3-phosphate dehydrogenase YP_002402624.1 1598246 R 585055 CDS YP_002402625.1 218694958 7146257 1599436..1599966 1 NC_011748.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1599966 cybB 7146257 cybB Escherichia coli 55989 cytochrome b561 YP_002402625.1 1599436 D 585055 CDS YP_002402626.1 218694959 7147577 1600211..1600384 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1600384 ydcA 7147577 ydcA Escherichia coli 55989 hypothetical protein YP_002402626.1 1600211 D 585055 CDS YP_002402627.1 218694960 7148383 complement(1600496..1600663) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type r : regulator; regulatory peptide 1600663 mokB 7148383 mokB Escherichia coli 55989 regulatory peptide YP_002402627.1 1600496 R 585055 CDS YP_002402628.1 218694961 7147676 1601004..1602644 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90008892, 92390356, 93259131, 6374654; Product type r : regulator; methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor 1602644 trg 7147676 trg Escherichia coli 55989 methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor YP_002402628.1 1601004 D 585055 CDS YP_002402629.1 218694962 7147840 complement(1602682..1603605) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1603605 ydcI 7147840 ydcI Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402629.1 1602682 R 585055 CDS YP_002402630.1 218694963 7148387 1603822..1605165 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1605165 ydcJ 7148387 ydcJ Escherichia coli 55989 hypothetical protein YP_002402630.1 1603822 D 585055 CDS YP_002402631.1 218694964 7148388 1605420..1607045 1 NC_011748.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1607045 mdoD 7148388 mdoD Escherichia coli 55989 glucan biosynthesis protein D YP_002402631.1 1605420 D 585055 CDS YP_002402632.1 218694965 7146799 complement(1606966..1607169) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1607169 7146799 EC55989_1556 Escherichia coli 55989 hypothetical protein YP_002402632.1 1606966 R 585055 CDS YP_002402633.1 218694966 7144603 1607185..1607409 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1607409 ydcH 7144603 ydcH Escherichia coli 55989 hypothetical protein YP_002402633.1 1607185 D 585055 CDS YP_002402634.1 218694967 7148386 1607457..1608008 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89364711; Product type e : enzyme; ribosomal-protein-L7/L12-serine acetyltransferase 1608008 rimL 7148386 rimL Escherichia coli 55989 ribosomal-protein-L7/L12-serine acetyltransferase YP_002402634.1 1607457 D 585055 CDS YP_002402635.1 218694968 7147421 complement(1608003..1608983) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 1608983 ydcK 7147421 ydcK Escherichia coli 55989 hypothetical protein YP_002402635.1 1608003 R 585055 CDS YP_002402636.1 218694969 7148389 1609107..1610099 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94222856, 2060788; Product type t : transporter; potassium-tellurite ethidium and proflavin transporter 1610099 tehA 7148389 tehA Escherichia coli 55989 potassium-tellurite ethidium and proflavin transporter YP_002402636.1 1609107 D 585055 CDS YP_002402637.1 218694970 7147773 1610096..1610689 1 NC_011748.1 with TehA confers resistance to tellurite; tellurite resistance protein TehB 1610689 tehB 7147773 tehB Escherichia coli 55989 tellurite resistance protein TehB YP_002402637.1 1610096 D 585055 CDS YP_002402638.1 218694971 7147774 1610992..1611660 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; lipoprotein 1611660 ydcL 7147774 ydcL Escherichia coli 55989 lipoprotein YP_002402638.1 1610992 D 585055 CDS YP_002402639.1 218694972 7148390 complement(1611678..1611845) 1 NC_011748.1 Evidence 7 : Gene remnant; Product type pe : enzyme; transposase ORF A (fragment), IS605 family 1611845 7148390 EC55989_1563 Escherichia coli 55989 transposase ORF A (fragment), IS605 family YP_002402639.1 1611678 R 585055 CDS YP_002402640.1 218694973 7144604 complement(1611957..1612112) 1 NC_011748.1 Evidence 7 : Gene remnant; Product type pe : enzyme; transposase ORF A (fragment), IS605 family 1612112 7144604 EC55989_1564 Escherichia coli 55989 transposase ORF A (fragment), IS605 family YP_002402640.1 1611957 R 585055 CDS YP_002402641.1 218694974 7144605 1612187..1613395 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase 1613395 ydcM 7144605 ydcM Escherichia coli 55989 transposase YP_002402641.1 1612187 D 585055 CDS YP_002402642.1 218694975 7148391 complement(1613435..1614610) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1885518; Product type pt : transporter; benzoate transporter 1614610 ydcO 7148391 ydcO Escherichia coli 55989 benzoate transporter YP_002402642.1 1613435 R 585055 CDS YP_002402643.1 218694976 7148395 1614702..1615238 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1615238 ydcN 7148395 ydcN Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402643.1 1614702 D 585055 CDS YP_002402644.1 218694977 7148394 1615311..1617272 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; peptidase 1617272 ydcP 7148394 ydcP Escherichia coli 55989 peptidase YP_002402644.1 1615311 D 585055 CDS YP_002402645.1 218694978 7148396 complement(1617364..1617594) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1617594 yncJ 7148396 yncJ Escherichia coli 55989 hypothetical protein YP_002402645.1 1617364 R 585055 CDS YP_002402646.1 218694979 7149298 1617995..1618432 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1618432 ydcQ 7149298 ydcQ Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402646.1 1617995 D 585055 CDS YP_002402647.1 218694980 7148397 1618511..1619917 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15223311; Product type pr : regulator; DNA-binding transcriptional regulator fused with a domain with PLP-binding motif 1619917 ydcR 7148397 ydcR Escherichia coli 55989 DNA-binding transcriptional regulator fused with a domain with PLP-binding motif YP_002402647.1 1618511 D 585055 CDS YP_002402648.1 218694981 7148398 1620162..1621307 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11683869; Product type pt : transporter; spermidine/putrescine transporter subunit ; periplasmic-binding component of ABC superfamily transporter 1621307 ydcS 7148398 ydcS Escherichia coli 55989 spermidine/putrescine transporter subunit ; periplasmic-binding component of ABC superfamily transporter YP_002402648.1 1620162 D 585055 CDS YP_002402649.1 218694982 7148399 1621325..1622338 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; spermidine/putrescine transporter subunit ; ATP-binding component of ABC superfamily tranporter 1622338 ydcT 7148399 ydcT Escherichia coli 55989 spermidine/putrescine transporter subunit ; ATP-binding component of ABC superfamily tranporter YP_002402649.1 1621325 D 585055 CDS YP_002402650.1 218694983 7148400 1622339..1623280 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; spermidine/putrescine transporter subunit ; permease of ABC superfamily transporter 1623280 ydcU 7148400 ydcU Escherichia coli 55989 spermidine/putrescine transporter subunit ; permease of ABC superfamily transporter YP_002402650.1 1622339 D 585055 CDS YP_002402651.1 218694984 7148401 1623270..1624064 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; spermidine/putrescine transporter subunit; permease component of ABC superfamily 1624064 ydcV 7148401 ydcV Escherichia coli 55989 spermidine/putrescine transporter subunit; permease component of ABC superfamily YP_002402651.1 1623270 D 585055 CDS YP_002402652.1 218694985 7148402 1624086..1625510 1 NC_011748.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 1625510 ydcW 7148402 ydcW Escherichia coli 55989 gamma-aminobutyraldehyde dehydrogenase YP_002402652.1 1624086 D 585055 CDS YP_002402653.1 218694986 7148403 1625720..1626529 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8257133, 11841212, 12771141; Product type pe : enzyme; acetyltransferase 1626529 7148403 EC55989_1577 Escherichia coli 55989 acetyltransferase YP_002402653.1 1625720 D 585055 CDS YP_002402654.1 218694987 7144606 1627146..1627394 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1627394 ydcX 7144606 ydcX Escherichia coli 55989 inner membrane protein YP_002402654.1 1627146 D 585055 CDS YP_002402655.1 218694988 7148404 1627480..1627713 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1627713 ydcY 7148404 ydcY Escherichia coli 55989 hypothetical protein YP_002402655.1 1627480 D 585055 CDS YP_002402656.1 218694989 7148405 complement(1627714..1628163) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1628163 ydcZ 7148405 ydcZ Escherichia coli 55989 inner membrane protein YP_002402656.1 1627714 R 585055 CDS YP_002402657.1 218694990 7148406 complement(1628160..1628912) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acyl-CoA N-acyltransferase 1628912 yncA 7148406 yncA Escherichia coli 55989 acyl-CoA N-acyltransferase YP_002402657.1 1628160 R 585055 CDS YP_002402658.1 218694991 7149291 1628859..1629896 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; conserved oxidoreductase, Zn-dependent and NAD(P)-binding 1629896 yncB 7149291 yncB Escherichia coli 55989 conserved oxidoreductase, Zn-dependent and NAD(P)-binding YP_002402658.1 1628859 D 585055 CDS YP_002402659.1 218694992 7149292 1630094..1630759 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11004173; Product type pr : regulator; DNA-binding transcriptional regulator 1630759 yncC 7149292 yncC Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402659.1 1630094 D 585055 CDS YP_002402660.1 218694993 7149293 complement(1630795..1632897) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : receptor; iron outer membrane receptor 1632897 yncD 7149293 yncD Escherichia coli 55989 iron outer membrane receptor YP_002402660.1 1630795 R 585055 CDS YP_002402661.1 218694994 7149294 1633139..1634200 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1634200 yncE 7149294 yncE Escherichia coli 55989 hypothetical protein YP_002402661.1 1633139 D 585055 CDS YP_002402662.1 218694995 7149295 complement(1634313..1635812) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005443; Product type t : transporter; L-asparagine transporter 1635812 ansP 7149295 ansP Escherichia coli 55989 L-asparagine transporter YP_002402662.1 1634313 R 585055 CDS YP_002402663.1 218694996 7145504 1636079..1636696 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; glutathione S-transferase-like protein 1636696 yncG 7145504 yncG Escherichia coli 55989 glutathione S-transferase-like protein YP_002402663.1 1636079 D 585055 CDS YP_002402664.1 218694997 7149296 1637768..1639912 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; VgrG protein, Encoded within repeats that are hotspots for chromosomal duplication formation; Function of protein is unknown 1639912 7149296 EC55989_1588 Escherichia coli 55989 VgrG protein, Encoded within repeats that are hotspots for chromosomal duplication formation; Function of protein is unknown YP_002402664.1 1637768 D 585055 CDS YP_002402665.1 218694998 7144607 1639980..1644221 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 1766878, 2403547, 2644231, 7934896; Product type h : extrachromosomal origin; rhsD element protein 1644221 rhsD 7144607 rhsD Escherichia coli 55989 rhsD element protein YP_002402665.1 1639980 D 585055 CDS YP_002402666.1 218694999 7147404 1644221..1644682 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9696756; hypothetical protein 1644682 7147404 EC55989_1590 Escherichia coli 55989 hypothetical protein YP_002402666.1 1644221 D 585055 CDS YP_002402667.1 218695000 7148983 1645701..1645994 1 NC_011748.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 1645994 7148983 EC55989_1592 Escherichia coli 55989 4-oxalocrotonate tautomerase YP_002402667.1 1645701 D 585055 CDS YP_002402668.1 218695001 7144609 complement(1645998..1646567) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1646567 yddH 7144609 yddH Escherichia coli 55989 hypothetical protein YP_002402668.1 1645998 R 585055 CDS YP_002402669.1 218695002 7148411 1646740..1647585 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20267568; Product type e : enzyme; N-hydroxyarylamine O-acetyltransferase 1647585 nhoA 7148411 nhoA Escherichia coli 55989 N-hydroxyarylamine O-acetyltransferase YP_002402669.1 1646740 D 585055 CDS YP_002402670.1 218695003 7146994 complement(1647681..1648574) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14611652, 15103639, 2233673; hypothetical protein 1648574 yddE 7146994 yddE Escherichia coli 55989 hypothetical protein YP_002402670.1 1647681 R 585055 CDS YP_002402671.1 218695004 7148409 complement(1648653..1649333) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 (NRZ), gamma subunit 1649333 narV 7148409 narV Escherichia coli 55989 nitrate reductase 2 (NRZ), gamma subunit YP_002402671.1 1648653 R 585055 CDS YP_002402672.1 218695005 7146976 complement(1649330..1650025) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410, 92186712; Product type f : factor; nitrate reductase 2 (NRZ), delta subunit (assembly subunit) 1650025 narW 7146976 narW Escherichia coli 55989 nitrate reductase 2 (NRZ), delta subunit (assembly subunit) YP_002402672.1 1649330 R 585055 CDS YP_002402673.1 218695006 7146977 complement(1650025..1651569) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type c : carrier; nitrate reductase 2 (NRZ), beta subunit 1651569 narY 7146977 narY Escherichia coli 55989 nitrate reductase 2 (NRZ), beta subunit YP_002402673.1 1650025 R 585055 CDS YP_002402674.1 218695007 7146979 complement(1651566..1655306) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 (NRZ), alpha subunit 1655306 narZ 7146979 narZ Escherichia coli 55989 nitrate reductase 2 (NRZ), alpha subunit YP_002402674.1 1651566 R 585055 CDS YP_002402675.1 218695008 7146980 complement(1655388..1656776) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95266795, 2233673; Product type t : transporter; nitrate/nitrite transporter 1656776 narU 7146980 narU Escherichia coli 55989 nitrate/nitrite transporter YP_002402675.1 1655388 R 585055 CDS YP_002402676.1 218695009 7146975 complement(1657100..1658431) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; glycoprotein with ribonuclease inhibitor domain (yddK) (modular protein) 1658431 7146975 EC55989_1602 Escherichia coli 55989 glycoprotein with ribonuclease inhibitor domain (yddK) (modular protein) YP_002402676.1 1657100 R 585055 CDS YP_002402677.1 218695010 7144610 complement(1658455..1658745) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7926834; Product type m : membrane component; outer membrane porin 1658745 yddL 7144610 yddL Escherichia coli 55989 outer membrane porin YP_002402677.1 1658455 R 585055 CDS YP_002402678.1 218695011 7148412 complement(1659004..1659828) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12410826; Product type t : transporter; hypothetical protein 1659828 yddG 7148412 yddG Escherichia coli 55989 hypothetical protein YP_002402678.1 1659004 R 585055 CDS YP_002402679.1 218695012 7148410 1660117..1663164 1 NC_011748.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-N subunit alpha, nitrate-inducible 1663164 fdnG 7148410 fdnG Escherichia coli 55989 formate dehydrogenase-N subunit alpha, nitrate-inducible YP_002402679.1 1660117 D 585055 CDS YP_002402680.1 218695013 7146069 1663177..1664061 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005553, 90375017, 92332427, 11884747, 1834669; Product type c : carrier; formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible 1664061 fdnH 7146069 fdnH Escherichia coli 55989 formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible YP_002402680.1 1663177 D 585055 CDS YP_002402681.1 218695014 7146070 1664054..1664707 1 NC_011748.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1664707 fdnI 7146070 fdnI Escherichia coli 55989 formate dehydrogenase-N subunit gamma YP_002402681.1 1664054 D 585055 CDS YP_002402682.1 218695015 7146071 complement(1664758..1665120) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1665120 yddM 7146071 yddM Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402682.1 1664758 R 585055 CDS YP_002402683.1 218695016 7148413 complement(1665189..1666199) 1 NC_011748.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase 1666199 adhP 7148413 adhP Escherichia coli 55989 alcohol dehydrogenase YP_002402683.1 1665189 R 585055 CDS YP_002402684.1 218695017 7145456 complement(1666333..1668030) 1 NC_011748.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase 1668030 sfcA 7145456 sfcA Escherichia coli 55989 malate dehydrogenase YP_002402684.1 1666333 R 585055 CDS YP_002402685.1 218695018 7147639 complement(1668426..1668641) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10498711, 13129944; Product type f : factor; biofilm-dependent modulation protein 1668641 bdm 7147639 bdm Escherichia coli 55989 biofilm-dependent modulation protein YP_002402685.1 1668426 R 585055 CDS YP_002402686.1 218695019 7145609 1668987..1669418 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14512736, 91350191, 9298646; Product type m : membrane component; osmotically inducible, stress-inducible membrane protein 1669418 osmC 7145609 osmC Escherichia coli 55989 osmotically inducible, stress-inducible membrane protein YP_002402686.1 1668987 D 585055 CDS YP_002402687.1 218695020 7147082 complement(1669474..1670400) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala transporter subunit ; ATP-binding component of ABC superfamily 1670400 ddpF 7147082 ddpF Escherichia coli 55989 D-ala-D-ala transporter subunit ; ATP-binding component of ABC superfamily YP_002402687.1 1669474 R 585055 CDS YP_002402688.1 218695021 7145873 complement(1670393..1671379) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala transporter subunit ; ATP-binding component of ABC superfamily 1671379 ddpD 7145873 ddpD Escherichia coli 55989 D-ala-D-ala transporter subunit ; ATP-binding component of ABC superfamily YP_002402688.1 1670393 R 585055 CDS YP_002402689.1 218695022 7145872 complement(1671376..1672272) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; ATP-dependent peptide transporter membrane subunit 1672272 ddpC 7145872 ddpC Escherichia coli 55989 ATP-dependent peptide transporter membrane subunit YP_002402689.1 1671376 R 585055 CDS YP_002402690.1 218695023 7145871 complement(1672269..1673291) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala transporter subunit ; membrane component of ABC superfamily 1673291 ddpB 7145871 ddpB Escherichia coli 55989 D-ala-D-ala transporter subunit ; membrane component of ABC superfamily YP_002402690.1 1672269 R 585055 CDS YP_002402691.1 218695024 7145870 complement(1673293..1674843) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-a la transporter subunit ; periplasmic-binding component of ABC superfamily 1674843 ddpA 7145870 ddpA Escherichia coli 55989 D-ala-D-a la transporter subunit ; periplasmic-binding component of ABC superfamily YP_002402691.1 1673293 R 585055 CDS YP_002402692.1 218695025 7145869 complement(1674857..1675438) 1 NC_011748.1 catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase 1675438 ddpX 7145869 ddpX Escherichia coli 55989 D-alanyl-D-alanine dipeptidase YP_002402692.1 1674857 R 585055 CDS YP_002402693.1 218695026 7145874 complement(1675696..1678095) 1 NC_011748.1 heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate; cAMP phosphodiesterase 1678095 dos 7145874 dos Escherichia coli 55989 cAMP phosphodiesterase YP_002402693.1 1675696 R 585055 CDS YP_002402694.1 218695027 7145943 complement(1678120..1679502) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16497924, 15142243; Product type pe : enzyme; diguanylate cyclase YddV 1679502 yddV 7145943 yddV Escherichia coli 55989 diguanylate cyclase YddV YP_002402694.1 1678120 R 585055 CDS YP_002402695.1 218695028 7148414 complement(1679874..1681193) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10960106; Product type lp : lipoprotein; lipoprotein 1681193 yddW 7148414 yddW Escherichia coli 55989 lipoprotein YP_002402695.1 1679874 R 585055 CDS YP_002402696.1 218695029 7148415 complement(1681324..1682859) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15795232, 15489450; Product type t : transporter; glutamate:gamma-aminobutyric acid antiporter 1682859 gadC 7148415 gadC Escherichia coli 55989 glutamate:gamma-aminobutyric acid antiporter YP_002402696.1 1681324 R 585055 CDS YP_002402697.1 218695030 7146242 complement(1683015..1684415) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12912902, 92155241, 92394884, 99406302, 8455549; Product type e : enzyme; glutamate decarboxylase 1684415 gadB 7146242 gadB Escherichia coli 55989 glutamate decarboxylase YP_002402697.1 1683015 R 585055 CDS YP_002402698.1 218695031 7146241 complement(1684777..1687572) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1659611, 11514505; Product type pe : enzyme; membrane-associated peptidase 1687572 pqqL 7146241 pqqL Escherichia coli 55989 membrane-associated peptidase YP_002402698.1 1684777 R 585055 CDS YP_002402699.1 218695032 7147238 complement(1687617..1689989) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; porin protein 1689989 yddB 7147238 yddB Escherichia coli 55989 porin protein YP_002402699.1 1687617 R 585055 CDS YP_002402700.1 218695033 7148408 complement(1690027..1691712) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; multidrug transporter fused subunits of ABC superfamily transporter: permease component; ATP-binding component 1691712 yddA 7148408 yddA Escherichia coli 55989 multidrug transporter fused subunits of ABC superfamily transporter: permease component; ATP-binding component YP_002402700.1 1690027 R 585055 CDS YP_002402701.1 218695034 7148407 complement(1692003..1693160) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pr : regulator; hypothetical protein 1693160 ydeM 7148407 ydeM Escherichia coli 55989 hypothetical protein YP_002402701.1 1692003 R 585055 CDS YP_002402702.1 218695035 7148421 complement(1693212..1694894) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; sulfatase 1694894 ydeN 7148421 ydeN Escherichia coli 55989 sulfatase YP_002402702.1 1693212 R 585055 CDS YP_002402703.1 218695036 7148422 complement(1695296..1696057) 1 NC_011748.1 regulates the cellular response to acid resistance; transcriptional regulator YdeO 1696057 ydeO 7148422 ydeO Escherichia coli 55989 transcriptional regulator YdeO YP_002402703.1 1695296 R 585055 CDS YP_002402704.1 218695037 7148423 complement(1696132..1696329) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1696329 7148423 EC55989_1632 Escherichia coli 55989 hypothetical protein YP_002402704.1 1696132 R 585055 CDS YP_002402705.1 218695038 7144611 complement(1696577..1698856) 1 NC_011748.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family; oxidoreductase 1698856 ydeP 7144611 ydeP Escherichia coli 55989 oxidoreductase YP_002402705.1 1696577 R 585055 CDS YP_002402706.1 218695039 7148424 complement(1699190..1700104) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 1700104 ydeQ 7148424 ydeQ Escherichia coli 55989 fimbrial-like adhesin protein YP_002402706.1 1699190 R 585055 CDS YP_002402707.1 218695040 7148425 complement(1700163..1700666) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 1700666 ydeR 7148425 ydeR Escherichia coli 55989 fimbrial-like adhesin protein YP_002402707.1 1700163 R 585055 CDS YP_002402708.1 218695041 7148426 complement(1700679..1701209) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 1701209 ydeS 7148426 ydeS Escherichia coli 55989 fimbrial-like adhesin protein YP_002402708.1 1700679 R 585055 CDS YP_002402709.1 218695042 7148427 complement(1701223..1703874) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; fimbrial outer membrane usher protein 1703874 7148427 EC55989_1637 Escherichia coli 55989 fimbrial outer membrane usher protein YP_002402709.1 1701223 R 585055 CDS YP_002402710.1 218695043 7144612 complement(1703916..1704635) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; Periplasmic chaperone precursor 1704635 7144612 EC55989_1638 Escherichia coli 55989 Periplasmic chaperone precursor YP_002402710.1 1703916 R 585055 CDS YP_002402711.1 218695044 7144613 complement(1704987..1705598) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; major fimbrial subunit FmlA 1705598 7144613 EC55989_1639 Escherichia coli 55989 major fimbrial subunit FmlA YP_002402711.1 1704987 R 585055 CDS YP_002402712.1 218695045 7144614 complement(1706006..1706185) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 1706185 yneL 7144614 yneL Escherichia coli 55989 transcriptional regulator YP_002402712.1 1706006 R 585055 CDS YP_002402713.1 218695046 7149309 complement(1706503..1707825) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358364, 94292428, 15576765; Product type r : regulator; regulator with hipB 1707825 hipA 7149309 hipA Escherichia coli 55989 regulator with hipB YP_002402713.1 1706503 R 585055 CDS YP_002402714.1 218695047 7146428 complement(1707825..1708091) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358364, 94292428, 15576765, 8021189; Product type r : regulator; DNA-binding transcriptional regulator HipB 1708091 hipB 7146428 hipB Escherichia coli 55989 DNA-binding transcriptional regulator HipB YP_002402714.1 1707825 R 585055 CDS YP_002402715.1 218695048 7146429 complement(1708300..1713720) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; lipoprotein/autotransporter domain-containing protein 1713720 7146429 EC55989_1643 Escherichia coli 55989 lipoprotein/autotransporter domain-containing protein YP_002402715.1 1708300 R 585055 CDS YP_002402716.1 218695049 7144615 complement(1714251..1715843) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15601708, 14622426; Product type e : enzyme; autoinducer-2 (AI-2) kinase 1715843 lsrK 7144615 lsrK Escherichia coli 55989 autoinducer-2 (AI-2) kinase YP_002402716.1 1714251 R 585055 CDS YP_002402717.1 218695050 7146751 complement(1715922..1716875) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16321939, 15601708, 14622426; Product type r : regulator; DNA-binding transcriptional regulator 1716875 lsrR 7146751 lsrR Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402717.1 1715922 R 585055 CDS YP_002402718.1 218695051 7146752 1717124..1718659 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12657059, 11722742; Product type t : transporter; fused AI2 transporter subunits of ABC superfamily: ATP-binding components 1718659 ego 7146752 ego Escherichia coli 55989 fused AI2 transporter subunits of ABC superfamily: ATP-binding components YP_002402718.1 1717124 D 585055 CDS YP_002402719.1 218695052 7145982 1718653..1719681 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter; AI2 transporter ; membrane component of ABC superfamily 1719681 lsrC 7145982 lsrC Escherichia coli 55989 AI2 transporter ; membrane component of ABC superfamily YP_002402719.1 1718653 D 585055 CDS YP_002402720.1 218695053 7146747 1719681..1720673 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter; AI2 transporter ; membrane component of ABC superfamily 1720673 lsrD 7146747 lsrD Escherichia coli 55989 AI2 transporter ; membrane component of ABC superfamily YP_002402720.1 1719681 D 585055 CDS YP_002402721.1 218695054 7146748 1720685..1721707 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter; AI2 transporter ; periplasmic-binding component of ABC superfamily 1721707 lsrB 7146748 lsrB Escherichia coli 55989 AI2 transporter ; periplasmic-binding component of ABC superfamily YP_002402721.1 1720685 D 585055 CDS YP_002402722.1 218695055 7146746 1721734..1722609 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; aldolase 1722609 lsrF 7146746 lsrF Escherichia coli 55989 aldolase YP_002402722.1 1721734 D 585055 CDS YP_002402723.1 218695056 7146749 1722633..1722923 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; autoinducer-2 (AI-2) modifying protein LsrG 1722923 lsrG 7146749 lsrG Escherichia coli 55989 autoinducer-2 (AI-2) modifying protein LsrG YP_002402723.1 1722633 D 585055 CDS YP_002402724.1 218695057 7146750 1722980..1723738 1 NC_011748.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1723738 tam 7146750 tam Escherichia coli 55989 trans-aconitate 2-methyltransferase YP_002402724.1 1722980 D 585055 CDS YP_002402725.1 218695058 7147749 complement(1723742..1724656) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1724656 yneE 7147749 yneE Escherichia coli 55989 inner membrane protein YP_002402725.1 1723742 R 585055 CDS YP_002402726.1 218695059 7149300 complement(1724863..1726314) 1 NC_011748.1 catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase 1726314 uxaB 7149300 uxaB Escherichia coli 55989 altronate oxidoreductase YP_002402726.1 1724863 R 585055 CDS YP_002402727.1 218695060 7147939 complement(1726541..1727959) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane-associated diguanylate cyclase (GGDEF domain) 1727959 yneF 7147939 yneF Escherichia coli 55989 membrane-associated diguanylate cyclase (GGDEF domain) YP_002402727.1 1726541 R 585055 CDS YP_002402728.1 218695061 7149301 complement(1728098..1728457) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1728457 yneG 7149301 yneG Escherichia coli 55989 hypothetical protein YP_002402728.1 1728098 R 585055 CDS YP_002402729.1 218695062 7149302 complement(1728457..1729383) 1 NC_011748.1 catalyzes the formation of glutamate from glutamine; glutaminase 1729383 yneH 7149302 yneH Escherichia coli 55989 glutaminase YP_002402729.1 1728457 R 585055 CDS YP_002402730.1 218695063 7149303 complement(1729447..1730835) 1 NC_011748.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; succinate semialdehyde dehydrogenase 1730835 yneI 7149303 yneI Escherichia coli 55989 succinate semialdehyde dehydrogenase YP_002402730.1 1729447 R 585055 CDS YP_002402731.1 218695064 7149304 1730936..1731817 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1731817 yneJ 7149304 yneJ Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402731.1 1730936 D 585055 CDS YP_002402732.1 218695065 7149308 1733158..1734348 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094697, 99369894, 8383113, 10438792; Product type t : transporter; sugar efflux transporter 1734348 ydeA 7149308 ydeA Escherichia coli 55989 sugar efflux transporter YP_002402732.1 1733158 D 585055 CDS YP_002402733.1 218695066 7148416 complement(1734373..1735038) 1 NC_011748.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC 1735038 marC 7148416 marC Escherichia coli 55989 multiple drug resistance protein MarC YP_002402733.1 1734373 R 585055 CDS YP_002402734.1 218695067 7146789 1735250..1735684 1 NC_011748.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1735684 marR 7146789 marR Escherichia coli 55989 DNA-binding transcriptional repressor MarR YP_002402734.1 1735250 D 585055 CDS YP_002402735.1 218695068 7146790 1735704..1736087 1 NC_011748.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1736087 marA 7146790 marA Escherichia coli 55989 DNA-binding transcriptional activator MarA YP_002402735.1 1735704 D 585055 CDS YP_002402736.1 218695069 7146787 1736119..1736337 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8383113; hypothetical protein 1736337 marB 7146787 marB Escherichia coli 55989 hypothetical protein YP_002402736.1 1736119 D 585055 CDS YP_002402737.1 218695070 7146788 complement(1736394..1737839) 1 NC_011748.1 converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase 1737839 celA 7146788 celA Escherichia coli 55989 6-phospho-beta-glucosidase YP_002402737.1 1736394 R 585055 CDS YP_002402738.1 218695071 7144616 complement(1737858..1739531) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; carbohydrate-specific outer membrane porin 1739531 7144616 EC55989_1669 Escherichia coli 55989 carbohydrate-specific outer membrane porin YP_002402738.1 1737858 R 585055 CDS YP_002402739.1 218695072 7144617 complement(1739587..1739901) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; PTS system lactose/cellobiose-specific transporter subunit IIA 1739901 7144617 EC55989_1670 Escherichia coli 55989 PTS system lactose/cellobiose-specific transporter subunit IIA YP_002402739.1 1739587 R 585055 CDS YP_002402740.1 218695073 7144618 complement(1739926..1741287) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; PTS system transporter subunit IIC 1741287 7144618 EC55989_1671 Escherichia coli 55989 PTS system transporter subunit IIC YP_002402740.1 1739926 R 585055 CDS YP_002402741.1 218695074 7144619 complement(1741363..1741674) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; cellobiose-specific phosphotransferase enzyme IIB component 1741674 7144619 EC55989_1672 Escherichia coli 55989 cellobiose-specific phosphotransferase enzyme IIB component YP_002402741.1 1741363 R 585055 CDS YP_002402742.1 218695075 7144620 1741873..1742571 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator HTH family 1742571 7144620 EC55989_1673 Escherichia coli 55989 DNA-binding transcriptional regulator HTH family YP_002402742.1 1741873 D 585055 CDS YP_002402743.1 218695076 7144621 complement(1742616..1743515) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20305052; Product type t : transporter; O-acetylserine/cysteine export protein 1743515 eamA 7144621 eamA Escherichia coli 55989 O-acetylserine/cysteine export protein YP_002402743.1 1742616 R 585055 CDS YP_002402744.1 218695077 7145966 1743710..1744897 1 NC_011748.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; MFS-type transporter YdeE 1744897 ydeE 7145966 ydeE Escherichia coli 55989 MFS-type transporter YdeE YP_002402744.1 1743710 D 585055 CDS YP_002402745.1 218695078 7148417 complement(1745339..1746229) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1746229 ydeH 7148417 ydeH Escherichia coli 55989 hypothetical protein YP_002402745.1 1745339 R 585055 CDS YP_002402746.1 218695079 7148418 complement(1746484..1746876) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1746876 ydeI 7148418 ydeI Escherichia coli 55989 hypothetical protein YP_002402746.1 1746484 R 585055 CDS YP_002402747.1 218695080 7148419 1747152..1747670 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A 1747670 ydeJ 7148419 ydeJ Escherichia coli 55989 competence damage-inducible protein A YP_002402747.1 1747152 D 585055 CDS YP_002402748.1 218695081 7148420 complement(1747715..1749760) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 216006, 8226676; Product type e : enzyme; dipeptidyl carboxypeptidase II 1749760 dcp 7148420 dcp Escherichia coli 55989 dipeptidyl carboxypeptidase II YP_002402748.1 1747715 R 585055 CDS YP_002402749.1 218695082 7145857 1749897..1750643 1 NC_011748.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1750643 ydfG 7145857 ydfG Escherichia coli 55989 3-hydroxy acid dehydrogenase YP_002402749.1 1749897 D 585055 CDS YP_002402750.1 218695083 7148434 1750732..1751418 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1751418 ydfH 7148434 ydfH Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402750.1 1750732 D 585055 CDS YP_002402751.1 218695084 7148435 1751596..1751799 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12084818; Product type pc : carrier; selenium carrying protein 1751799 ydfZ 7148435 ydfZ Escherichia coli 55989 selenium carrying protein YP_002402751.1 1751596 D 585055 CDS YP_002402752.1 218695085 7148445 complement(1751835..1753295) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; mannonate dehydrogenase 1753295 ydfI 7148445 ydfI Escherichia coli 55989 mannonate dehydrogenase YP_002402752.1 1751835 R 585055 CDS YP_002402753.1 218695086 7148436 complement(1753384..1754667) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 1754667 ydfJ 7148436 ydfJ Escherichia coli 55989 transporter YP_002402753.1 1753384 R 585055 CDS YP_002402754.1 218695087 7148437 1755403..1755585 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1755585 yciG 7148437 yciG Escherichia coli 55989 hypothetical protein YP_002402754.1 1755403 D 585055 CDS YP_002402755.1 218695088 7148344 1755658..1756164 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3058546, 8455549; hypothetical protein 1756164 yciF 7148344 yciF Escherichia coli 55989 hypothetical protein YP_002402755.1 1755658 D 585055 CDS YP_002402756.1 218695089 7148342 1756201..1756707 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15388941, 3058546, 8455549; hypothetical protein 1756707 yciE 7148342 yciE Escherichia coli 55989 hypothetical protein YP_002402756.1 1756201 D 585055 CDS YP_002402757.1 218695090 7148340 1756726..1757616 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; Manganese Catalase of prophage 1757616 7148340 EC55989_1689 Escherichia coli 55989 Manganese Catalase of prophage YP_002402757.1 1756726 D 585055 CDS YP_002402758.1 218695091 7144622 complement(1757736..1758317) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; tail fiber chaperone; Qin prophage 1758317 tfaQ 7144622 tfaQ Escherichia coli 55989 tail fiber chaperone; Qin prophage YP_002402758.1 1757736 R 585055 CDS YP_002402759.1 218695092 7147779 complement(1758317..1761280) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber protein 1761280 7147779 EC55989_1691 Escherichia coli 55989 tail fiber protein YP_002402759.1 1758317 R 585055 CDS YP_002402760.1 218695093 7144623 complement(1761345..1761944) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; Lom-like outer membrane protein of phage origin 1761944 7144623 EC55989_1692 Escherichia coli 55989 Lom-like outer membrane protein of phage origin YP_002402760.1 1761345 R 585055 CDS YP_002402761.1 218695094 7144624 complement(1762014..1765427) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J 1765427 7144624 EC55989_1693 Escherichia coli 55989 Host specificity protein J YP_002402761.1 1762014 R 585055 CDS YP_002402762.1 218695095 7144625 complement(1765488..1766135) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail assembly protein I from prophage 1766135 7144625 EC55989_1694 Escherichia coli 55989 Tail assembly protein I from prophage YP_002402762.1 1765488 R 585055 CDS YP_002402763.1 218695096 7144626 complement(1766033..1766776) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber component K of prophage 1766776 7144626 EC55989_1695 Escherichia coli 55989 tail fiber component K of prophage YP_002402763.1 1766033 R 585055 CDS YP_002402764.1 218695097 7144627 complement(1766782..1767480) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein L 1767480 7144627 EC55989_1696 Escherichia coli 55989 Minor tail protein L YP_002402764.1 1766782 R 585055 CDS YP_002402765.1 218695098 7144628 complement(1767490..1767819) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein M 1767819 7144628 EC55989_1697 Escherichia coli 55989 Minor tail protein M YP_002402765.1 1767490 R 585055 CDS YP_002402766.1 218695099 7144629 complement(1767819..1770905) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail length tape measure protein from prophage 1770905 7144629 EC55989_1698 Escherichia coli 55989 tail length tape measure protein from prophage YP_002402766.1 1767819 R 585055 CDS YP_002402767.1 218695100 7144630 complement(1770847..1771176) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; minor tail protein T of prophage 1771176 7144630 EC55989_1699 Escherichia coli 55989 minor tail protein T of prophage YP_002402767.1 1770847 R 585055 CDS YP_002402768.1 218695101 7144631 complement(1771185..1771613) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; minor tail component of prophage 1771613 7144631 EC55989_1700 Escherichia coli 55989 minor tail component of prophage YP_002402768.1 1771185 R 585055 CDS YP_002402769.1 218695102 7144639 complement(1771632..1772450) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail protein V 1772450 7144639 EC55989_1701 Escherichia coli 55989 Major tail protein V YP_002402769.1 1771632 R 585055 CDS YP_002402770.1 218695103 7144640 complement(1772386..1772799) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein U 1772799 7144640 EC55989_1702 Escherichia coli 55989 Minor tail protein U YP_002402770.1 1772386 R 585055 CDS YP_002402771.1 218695104 7144641 complement(1772784..1773362) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein Z (GPZ) of prophage 1773362 7144641 EC55989_1703 Escherichia coli 55989 Minor tail protein Z (GPZ) of prophage YP_002402771.1 1772784 R 585055 CDS YP_002402772.1 218695105 7144642 complement(1773374..1773649) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; prophage protein 1773649 7144642 EC55989_1704 Escherichia coli 55989 prophage protein YP_002402772.1 1773374 R 585055 CDS YP_002402773.1 218695106 7144643 complement(1773642..1774010) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; prophage protein 1774010 7144643 EC55989_1705 Escherichia coli 55989 prophage protein YP_002402773.1 1773642 R 585055 CDS YP_002402774.1 218695107 7144644 complement(1774052..1776271) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; ATP-dependent Clp protease proteolytic subunit 1776271 7144644 EC55989_1706 Escherichia coli 55989 ATP-dependent Clp protease proteolytic subunit YP_002402774.1 1774052 R 585055 CDS YP_002402775.1 218695108 7144645 complement(1776024..1777604) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; portal protein (head-tail preconnector protein) from prophage 1777604 7144645 EC55989_1707 Escherichia coli 55989 portal protein (head-tail preconnector protein) from prophage YP_002402775.1 1776024 R 585055 CDS YP_002402776.1 218695109 7144646 complement(1777532..1777750) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; prophage protein 1777750 7144646 EC55989_1708 Escherichia coli 55989 prophage protein YP_002402776.1 1777532 R 585055 CDS YP_002402777.1 218695110 7144647 complement(1777741..1779843) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; DNA packaging protein of prophage ( terminase large subunit) 1779843 7144647 EC55989_1709 Escherichia coli 55989 DNA packaging protein of prophage ( terminase large subunit) YP_002402777.1 1777741 R 585055 CDS YP_002402778.1 218695111 7144648 complement(1779843..1780337) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; prophage protein 1780337 7144648 EC55989_1710 Escherichia coli 55989 prophage protein YP_002402778.1 1779843 R 585055 CDS YP_002402779.1 218695112 7144649 complement(1780890..1781096) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1781096 7144649 EC55989_1711 Escherichia coli 55989 hypothetical protein YP_002402779.1 1780890 R 585055 CDS YP_002402780.1 218695113 7144650 1781384..1781794 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage 1781794 ydfO 7144650 ydfO Escherichia coli 55989 Qin prophage YP_002402780.1 1781384 D 585055 CDS YP_002402781.1 218695114 7148438 complement(1782114..1782578) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : enzyme; murein endopeptidase; DLP12 prophage 1782578 rzpD 7148438 rzpD Escherichia coli 55989 murein endopeptidase; DLP12 prophage YP_002402781.1 1782114 R 585055 CDS YP_002402782.1 218695115 7147598 complement(1782580..1782753) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1782753 7147598 EC55989_1714 Escherichia coli 55989 phage protein YP_002402782.1 1782580 R 585055 CDS YP_002402783.1 218695116 7144651 complement(1782877..1783410) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane-associated lysozyme; Qin prophage 1783410 ydfQ 7144651 ydfQ Escherichia coli 55989 membrane-associated lysozyme; Qin prophage YP_002402783.1 1782877 R 585055 CDS YP_002402784.1 218695117 7144652 complement(1783785..1784000) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : enzyme; phage lysis protein S; DLP12 prophage 1784000 essD 7144652 essD Escherichia coli 55989 phage lysis protein S; DLP12 prophage YP_002402784.1 1783785 R 585055 CDS YP_002402785.1 218695118 7146024 complement(1784252..1784647) 1 NC_011748.1 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; tolA protein (fragment) of prophage 1784647 7146024 EC55989_1718 Escherichia coli 55989 tolA protein (fragment) of prophage YP_002402785.1 1784252 R 585055 CDS YP_002402786.1 218695119 7144653 complement(1784798..1785226) 1 NC_011748.1 Evidence 7 : Gene remnant; PubMedId : 2068069, 10404600, 8978668; Product type h : extrachromosomal origin; TolA protein (fragment) of prophage 1785226 tolA 7144653 tolA Escherichia coli 55989 TolA protein (fragment) of prophage YP_002402786.1 1784798 R 585055 CDS YP_002402787.1 218695120 7144654 complement(1785760..1786113) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 1786113 7144654 EC55989_1721 Escherichia coli 55989 hypothetical protein YP_002402787.1 1785760 R 585055 CDS YP_002402788.1 218695121 7145397 1786258..1786422 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 1786422 7145397 EC55989_1722 Escherichia coli 55989 hypothetical protein YP_002402788.1 1786258 D 585055 CDS YP_002402789.1 218695122 7145396 complement(1786620..1787441) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; antitermination protein Q of prophage 1787441 7145396 EC55989_1723 Escherichia coli 55989 antitermination protein Q of prophage YP_002402789.1 1786620 R 585055 CDS YP_002402790.1 218695123 7144657 complement(1787438..1787815) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; crossover junction endodeoxyribonuclease rusA (Holliday junction nuclease rusA) (Holliday juction resolvase) (Gp67) 1787815 7144657 EC55989_1724 Escherichia coli 55989 crossover junction endodeoxyribonuclease rusA (Holliday junction nuclease rusA) (Holliday juction resolvase) (Gp67) YP_002402790.1 1787438 R 585055 CDS YP_002402791.1 218695124 7144658 complement(1787619..1787819) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1787819 7144658 EC55989_1725 Escherichia coli 55989 hypothetical protein YP_002402791.1 1787619 R 585055 CDS YP_002402792.1 218695125 7144659 complement(1787825..1788874) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage 1788874 ydfU 7144659 ydfU Escherichia coli 55989 Qin prophage YP_002402792.1 1787825 R 585055 CDS YP_002402793.1 218695126 7148444 complement(1789221..1789472) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2990907; Product type h : extrachromosomal origin; Qin prophage 1789472 rem 7148444 rem Escherichia coli 55989 Qin prophage YP_002402793.1 1789221 R 585055 CDS YP_002402794.1 218695127 7147372 complement(1790060..1790383) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 1790383 7147372 EC55989_1728 Escherichia coli 55989 hypothetical protein YP_002402794.1 1790060 R 585055 CDS YP_002402795.1 218695128 7144660 complement(1790432..1791469) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1791469 7144660 EC55989_1729 Escherichia coli 55989 hypothetical protein YP_002402795.1 1790432 R 585055 CDS YP_002402796.1 218695129 7144661 complement(1791685..1792110) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1792110 7144661 EC55989_1730 Escherichia coli 55989 phage protein YP_002402796.1 1791685 R 585055 CDS YP_002402797.1 218695130 7144662 complement(1792151..1793170) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1793170 7144662 EC55989_1731 Escherichia coli 55989 hypothetical protein YP_002402797.1 1792151 R 585055 CDS YP_002402798.1 218695131 7144663 complement(1793097..1793618) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1793618 7144663 EC55989_1732 Escherichia coli 55989 hypothetical protein YP_002402798.1 1793097 R 585055 CDS YP_002402799.1 218695132 7144664 complement(1793602..1793832) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88232418, 3532030; Product type h : extrachromosomal origin; DNA-binding transcriptional regulator DicC 1793832 dicC 7144664 dicC Escherichia coli 55989 DNA-binding transcriptional regulator DicC YP_002402799.1 1793602 R 585055 CDS YP_002402800.1 218695133 7145910 1793910..1794317 1 NC_011748.1 The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown.; transcriptional repressor DicA 1794317 dicA 7145910 dicA Escherichia coli 55989 transcriptional repressor DicA YP_002402800.1 1793910 D 585055 CDS YP_002402801.1 218695134 7145908 1794486..1794641 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage 1794641 ydfA 7145908 ydfA Escherichia coli 55989 Qin prophage YP_002402801.1 1794486 D 585055 CDS YP_002402802.1 218695135 7148429 1794601..1795218 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1795218 7148429 EC55989_1736 Escherichia coli 55989 hypothetical protein YP_002402802.1 1794601 D 585055 CDS YP_002402803.1 218695136 7145913 1795600..1795893 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; regulator of cell division encoded by prophage 1795893 7145913 EC55989_1737 Escherichia coli 55989 regulator of cell division encoded by prophage YP_002402803.1 1795600 D 585055 CDS YP_002402804.1 218695137 7144666 1795890..1796081 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage 1796081 ydfD 7144666 ydfD Escherichia coli 55989 Qin prophage YP_002402804.1 1795890 D 585055 CDS YP_002402805.1 218695138 7148433 1796175..1798646 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; exonuclease from phage origin 1798646 7148433 EC55989_1739 Escherichia coli 55989 exonuclease from phage origin YP_002402805.1 1796175 D 585055 CDS YP_002402806.1 218695139 7144667 1798719..1798970 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; prophage excisionase 1798970 xis 7144667 xis Escherichia coli 55989 prophage excisionase YP_002402806.1 1798719 D 585055 CDS YP_002402807.1 218695140 7147991 1798990..1800285 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; defective integrase; Qin prophage 1800285 intQ 7147991 intQ Escherichia coli 55989 defective integrase; Qin prophage YP_002402807.1 1798990 D 585055 CDS YP_002402808.1 218695141 7146609 complement(1800305..1800415) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 1800415 ynfP 7146609 ynfP Escherichia coli 55989 hypothetical protein YP_002402808.1 1800305 R 585055 CDS YP_002402809.1 218695142 7147441 1801318..1802526 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L 1802526 7147441 EC55989_1744 Escherichia coli 55989 transposase, IS4 family, IS10L YP_002402809.1 1801318 D 585055 CDS YP_002402810.1 218695143 7147540 complement(1802842..1804056) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : enzyme; enolase/dehydratase 1804056 rspA 7147540 rspA Escherichia coli 55989 enolase/dehydratase YP_002402810.1 1802842 R 585055 CDS YP_002402811.1 218695144 7147537 complement(1804262..1804588) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 1804588 ynfA 7147537 ynfA Escherichia coli 55989 hypothetical protein YP_002402811.1 1804262 R 585055 CDS YP_002402812.1 218695145 7149310 1804723..1805064 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1805064 ynfB 7149310 ynfB Escherichia coli 55989 hypothetical protein YP_002402812.1 1804723 D 585055 CDS YP_002402813.1 218695146 7149311 1805099..1805659 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94357898; Product type e : enzyme; spermidine N1-acetyltransferase 1805659 speG 7149311 speG Escherichia coli 55989 spermidine N1-acetyltransferase YP_002402813.1 1805099 D 585055 CDS YP_002402814.1 218695147 7147691 complement(1805662..1806372) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1806372 ynfC 7147691 ynfC Escherichia coli 55989 hypothetical protein YP_002402814.1 1805662 R 585055 CDS YP_002402815.1 218695148 7149312 1806480..1806785 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9868784; hypothetical protein 1806785 ynfD 7149312 ynfD Escherichia coli 55989 hypothetical protein YP_002402815.1 1806480 D 585055 CDS YP_002402816.1 218695149 7149313 1806984..1809410 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme; oxidoreductase subunit 1809410 ynfE 7149313 ynfE Escherichia coli 55989 oxidoreductase subunit YP_002402816.1 1806984 D 585055 CDS YP_002402817.1 218695150 7149314 1809471..1811894 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme; oxidoreductase subunit 1811894 ynfF 7149314 ynfF Escherichia coli 55989 oxidoreductase subunit YP_002402817.1 1809471 D 585055 CDS YP_002402818.1 218695151 7149315 1811905..1812522 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type c : carrier; oxidoreductase, Fe-S subunit 1812522 ynfG 7149315 ynfG Escherichia coli 55989 oxidoreductase, Fe-S subunit YP_002402818.1 1811905 D 585055 CDS YP_002402819.1 218695152 7149316 1812524..1813378 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type m : membrane component; oxidoreductase, membrane subunit 1813378 ynfH 7149316 ynfH Escherichia coli 55989 oxidoreductase, membrane subunit YP_002402819.1 1812524 D 585055 CDS YP_002402820.1 218695153 7149317 1813421..1814035 1 NC_011748.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1814035 dmsD 7149317 dmsD Escherichia coli 55989 twin-argninine leader-binding protein DmsD YP_002402820.1 1813421 D 585055 CDS YP_002402821.1 218695154 7145931 1814230..1815486 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12384697; Product type pt : transporter; voltage-gated ClC-type chloride channel ClcB 1815486 clcB 7145931 clcB Escherichia coli 55989 voltage-gated ClC-type chloride channel ClcB YP_002402821.1 1814230 D 585055 CDS YP_002402822.1 218695155 7145719 complement(1815439..1816134) 1 NC_011748.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 1816134 ynfK 7145719 ynfK Escherichia coli 55989 dithiobiotin synthetase YP_002402822.1 1815439 R 585055 CDS YP_002402823.1 218695156 7149318 complement(1816259..1817479) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10318813, 20490366, 6989798, 99340206, 99395104, 99398866, 7766024; Product type r : regulator; DNA-binding transcriptional repressor 1817479 dgsA 7149318 dgsA Escherichia coli 55989 DNA-binding transcriptional repressor YP_002402823.1 1816259 R 585055 CDS YP_002402824.1 218695157 7145900 complement(1817614..1818507) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1818507 ynfL 7145900 ynfL Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402824.1 1817614 R 585055 CDS YP_002402825.1 218695158 7149319 1818614..1819867 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter; MFS type 1819867 ynfM 7149319 ynfM Escherichia coli 55989 transporter; MFS type YP_002402825.1 1818614 D 585055 CDS YP_002402826.1 218695159 7149320 1820291..1820599 1 NC_011748.1 required for growth and survival under moderately acid conditions; acid shock protein 1820599 asr 7149320 asr Escherichia coli 55989 acid shock protein YP_002402826.1 1820291 D 585055 CDS YP_002402827.1 218695160 7145574 1820875..1821696 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; metallopeptidase 1821696 ydgD 7145574 ydgD Escherichia coli 55989 metallopeptidase YP_002402827.1 1820875 D 585055 CDS YP_002402828.1 218695161 7148448 complement(1821735..1822064) 1 NC_011748.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI 1822064 mdtI 7148448 mdtI Escherichia coli 55989 multidrug efflux system protein MdtI YP_002402828.1 1821735 R 585055 CDS YP_002402829.1 218695162 7146810 complement(1822051..1822416) 1 NC_011748.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ 1822416 mdtJ 7146810 mdtJ Escherichia coli 55989 multidrug efflux system protein MdtJ YP_002402829.1 1822051 R 585055 CDS YP_002402830.1 218695163 7146811 1822828..1823862 1 NC_011748.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; transporter 1823862 tqsA 7146811 tqsA Escherichia coli 55989 transporter YP_002402830.1 1822828 D 585055 CDS YP_002402831.1 218695164 7148449 complement(1823887..1825275) 1 NC_011748.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase 1825275 pntB 7148449 pntB Escherichia coli 55989 pyridine nucleotide transhydrogenase YP_002402831.1 1823887 R 585055 CDS YP_002402832.1 218695165 7147205 complement(1825286..1826818) 1 NC_011748.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha 1826818 pntA 7147205 pntA Escherichia coli 55989 NAD(P) transhydrogenase subunit alpha YP_002402832.1 1825286 R 585055 CDS YP_002402833.1 218695166 7147204 1827342..1828286 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1828286 ydgH 7147204 ydgH Escherichia coli 55989 hypothetical protein YP_002402833.1 1827342 D 585055 CDS YP_002402834.1 218695167 7148450 1828472..1829854 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1311296; Product type pt : transporter; arginine/ornithine antiporter transporter 1829854 ydgI 7148450 ydgI Escherichia coli 55989 arginine/ornithine antiporter transporter YP_002402834.1 1828472 D 585055 CDS YP_002402835.1 218695168 7148451 1829891..1830613 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14617668; Product type e : enzyme; short chain dehydrogenase 1830613 folM 7148451 folM Escherichia coli 55989 short chain dehydrogenase YP_002402835.1 1829891 D 585055 CDS YP_002402836.1 218695169 7146174 complement(1830610..1830945) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein associated with alginate biosynthesis 1830945 ydgC 7146174 ydgC Escherichia coli 55989 inner membrane protein associated with alginate biosynthesis YP_002402836.1 1830610 R 585055 CDS YP_002402837.1 218695170 7148447 1831065..1831793 1 NC_011748.1 response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1831793 rstA 7148447 rstA Escherichia coli 55989 DNA-binding transcriptional regulator RstA YP_002402837.1 1831065 D 585055 CDS YP_002402838.1 218695171 7147543 1831797..1833098 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93086426, 1495392, 1925016, 2646639; Product type r : regulator; sensor protein RstB 1833098 rstB 7147543 rstB Escherichia coli 55989 sensor protein RstB YP_002402838.1 1831797 D 585055 CDS YP_002402839.1 218695172 7147544 1833174..1834103 1 NC_011748.1 binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1834103 tus 7147544 tus Escherichia coli 55989 DNA replication terminus site-binding protein YP_002402839.1 1833174 D 585055 CDS YP_002402840.1 218695173 7147874 complement(1834100..1835503) 1 NC_011748.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase 1835503 fumC 7147874 fumC Escherichia coli 55989 fumarate hydratase YP_002402840.1 1834100 R 585055 CDS YP_002402841.1 218695174 7146232 complement(1835646..1837292) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193096, 88268900, 92011457, 3005475, 6328431, 9298646; Product type e : enzyme; fumarate hydratase (fumarase A), aerobic Class I 1837292 fumA 7146232 fumA Escherichia coli 55989 fumarate hydratase (fumarase A), aerobic Class I YP_002402841.1 1835646 R 585055 CDS YP_002402842.1 218695175 7146230 1837491..1838666 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 6397402; Product type e : enzyme; mannose-6-phosphate isomerase 1838666 manA 7146230 manA Escherichia coli 55989 mannose-6-phosphate isomerase YP_002402842.1 1837491 D 585055 CDS YP_002402843.1 218695176 7146781 1838767..1840275 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1840275 ydgA 7146781 ydgA Escherichia coli 55989 hypothetical protein YP_002402843.1 1838767 D 585055 CDS YP_002402844.1 218695177 7148446 complement(1840320..1841585) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15774881; Product type t : transporter; outer membrane porin protein 1841585 uidC 7148446 uidC Escherichia coli 55989 outer membrane porin protein YP_002402844.1 1840320 R 585055 CDS YP_002402845.1 218695178 7147911 complement(1841624..1842997) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3534890; Product type t : transporter; glucuronide transporter 1842997 uidB 7147911 uidB Escherichia coli 55989 glucuronide transporter YP_002402845.1 1841624 R 585055 CDS YP_002402846.1 218695179 7147910 complement(1842994..1844805) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87041472, 88038341, 2103475, 8125312; Product type e : enzyme; beta-D-glucuronidase 1844805 uidA 7147910 uidA Escherichia coli 55989 beta-D-glucuronidase YP_002402846.1 1842994 R 585055 CDS YP_002402847.1 218695180 7147909 complement(1845194..1845784) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88038341, 2823062, 3934044, 11115104; Product type r : regulator; DNA-binding transcriptional repressor 1845784 uidR 7147909 uidR Escherichia coli 55989 DNA-binding transcriptional repressor YP_002402847.1 1845194 R 585055 CDS YP_002402848.1 218695181 7147912 complement(1846013..1846780) 1 NC_011748.1 Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase 1846780 hdhA 7147912 hdhA Escherichia coli 55989 7-alpha-hydroxysteroid dehydrogenase YP_002402848.1 1846013 R 585055 CDS YP_002402849.1 218695182 7146405 complement(1846892..1847920) 1 NC_011748.1 regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI 1847920 malI 7146405 malI Escherichia coli 55989 DNA-binding transcriptional repressor MalI YP_002402849.1 1846892 R 585055 CDS YP_002402850.1 218695183 7146771 1848095..1849687 1 NC_011748.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 1849687 malX 7146771 malX Escherichia coli 55989 bifunctional PTS system maltose and glucose-specific transporter subunits IICB YP_002402850.1 1848095 D 585055 CDS YP_002402851.1 218695184 7146778 1849697..1850869 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20164451, 7665481, 91310596; Product type e : enzyme; bifunctional beta-cystathionase and regulator of maltose regulon 1850869 malY 7146778 malY Escherichia coli 55989 bifunctional beta-cystathionase and regulator of maltose regulon YP_002402851.1 1849697 D 585055 CDS YP_002402852.1 218695185 7146779 1850973..1851974 1 NC_011748.1 catalyzes the formation of inosine from adenosine; adenosine deaminase 1851974 add 7146779 add Escherichia coli 55989 adenosine deaminase YP_002402852.1 1850973 D 585055 CDS YP_002402853.1 218695186 7145453 complement(1852009..1853049) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase 1853049 ydgJ 7145453 ydgJ Escherichia coli 55989 oxidoreductase YP_002402853.1 1852009 R 585055 CDS YP_002402854.1 218695187 7148452 1853217..1853417 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20392465, 10931331; Product type m : membrane component; beta-lactam resistance membrane protein 1853417 blr 7148452 blr Escherichia coli 55989 beta-lactam resistance membrane protein YP_002402854.1 1853217 D 585055 CDS YP_002402855.1 218695188 7145634 1853690..1853905 1 NC_011748.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1853905 ydgT 7145634 ydgT Escherichia coli 55989 oriC-binding nucleoid-associated protein YP_002402855.1 1853690 D 585055 CDS YP_002402856.1 218695189 7148455 1853991..1854431 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1854431 ydgK 7148455 ydgK Escherichia coli 55989 inner membrane protein YP_002402856.1 1853991 D 585055 CDS YP_002402857.1 218695190 7148453 1854508..1855089 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411911, 10637328, 12773378; Product type pm : membrane component; Na(+)-translocating NADH-quinone reductase subunit E 1855089 rsxA 7148453 rsxA Escherichia coli 55989 Na(+)-translocating NADH-quinone reductase subunit E YP_002402857.1 1854508 D 585055 CDS YP_002402858.1 218695191 7147546 1855089..1855667 1 NC_011748.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1855667 rsxB 7147546 rsxB Escherichia coli 55989 electron transport complex protein RnfB YP_002402858.1 1855089 D 585055 CDS YP_002402859.1 218695192 7147547 1855660..1857786 1 NC_011748.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1857786 rsxC 7147547 rsxC Escherichia coli 55989 electron transport complex protein RnfC YP_002402859.1 1855660 D 585055 CDS YP_002402860.1 218695193 7147548 1857787..1858845 1 NC_011748.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1858845 rnfD 7147548 rnfD Escherichia coli 55989 electron transport complex protein RnfD YP_002402860.1 1857787 D 585055 CDS YP_002402861.1 218695194 7147549 1858849..1859469 1 NC_011748.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1859469 rsxG 7147549 rsxG Escherichia coli 55989 electron transport complex protein RnfG YP_002402861.1 1858849 D 585055 CDS YP_002402862.1 218695195 7147551 1859473..1860168 1 NC_011748.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex protein RsxE 1860168 rsxE 7147551 rsxE Escherichia coli 55989 electron transport complex protein RsxE YP_002402862.1 1859473 D 585055 CDS YP_002402863.1 218695196 7147550 1860168..1860803 1 NC_011748.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1860803 nth 7147550 nth Escherichia coli 55989 endonuclease III YP_002402863.1 1860168 D 585055 CDS YP_002402864.1 218695197 7147035 1861414..1862916 1 NC_011748.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; tripeptide transporter permease 1862916 tppB 7147035 tppB Escherichia coli 55989 tripeptide transporter permease YP_002402864.1 1861414 D 585055 CDS YP_002402865.1 218695198 7148454 1863022..1863627 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95096109, 2185038, 9680481; Product type e : enzyme; glutathionine S-transferase 1863627 gst 7148454 gst Escherichia coli 55989 glutathionine S-transferase YP_002402865.1 1863022 D 585055 CDS YP_002402866.1 218695199 7146377 complement(1863671..1864534) 1 NC_011748.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase 1864534 pdxY 7146377 pdxY Escherichia coli 55989 pyridoxamine kinase YP_002402866.1 1863671 R 585055 CDS YP_002402867.1 218695200 7147129 complement(1864593..1865867) 1 NC_011748.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase 1865867 tyrS 7147129 tyrS Escherichia coli 55989 tyrosyl-tRNA synthetase YP_002402867.1 1864593 R 585055 CDS YP_002402868.1 218695201 7147885 complement(1865996..1866652) 1 NC_011748.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase 1866652 pdxH 7147885 pdxH Escherichia coli 55989 pyridoxamine 5'-phosphate oxidase YP_002402868.1 1865996 R 585055 CDS YP_002402869.1 218695202 7147126 complement(1866711..1867040) 1 NC_011748.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor 1867040 ydhA 7147126 ydhA Escherichia coli 55989 lysozyme inhibitor YP_002402869.1 1866711 R 585055 CDS YP_002402870.1 218695203 7148456 complement(1867138..1868247) 1 NC_011748.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase 1868247 anmK 7148456 anmK Escherichia coli 55989 anhydro-N-acetylmuramic acid kinase YP_002402870.1 1867138 R 585055 CDS YP_002402871.1 218695204 7145501 1868521..1868988 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8544813; Product type lp : lipoprotein; outer membrane lipoprotein 1868988 slyB 7145501 slyB Escherichia coli 55989 outer membrane lipoprotein YP_002402871.1 1868521 D 585055 CDS YP_002402872.1 218695205 7147663 complement(1869035..1869469) 1 NC_011748.1 Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA 1869469 slyA 7147663 slyA Escherichia coli 55989 transcriptional regulator SlyA YP_002402872.1 1869035 R 585055 CDS YP_002402873.1 218695206 7147662 1869670..1869906 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1869906 ydhI 7147662 ydhI Escherichia coli 55989 inner membrane protein YP_002402873.1 1869670 D 585055 CDS YP_002402874.1 218695207 7148461 1869909..1870766 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12900028; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 1870766 ydhJ 7148461 ydhJ Escherichia coli 55989 undecaprenyl pyrophosphate phosphatase YP_002402874.1 1869909 D 585055 CDS YP_002402875.1 218695208 7148462 1870766..1872778 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1872778 ydhK 7148462 ydhK Escherichia coli 55989 inner membrane protein YP_002402875.1 1870766 D 585055 CDS YP_002402876.1 218695209 7148463 complement(1872779..1873300) 1 NC_011748.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase 1873300 sodC 7148463 sodC Escherichia coli 55989 superoxide dismutase YP_002402876.1 1872779 R 585055 CDS YP_002402877.1 218695210 7147673 complement(1873381..1874277) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase 1874277 ydhF 7147673 ydhF Escherichia coli 55989 oxidoreductase YP_002402877.1 1873381 R 585055 CDS YP_002402878.1 218695211 7148460 complement(1874326..1874736) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1874736 ydhL 7148460 ydhL Escherichia coli 55989 hypothetical protein YP_002402878.1 1874326 R 585055 CDS YP_002402879.1 218695212 7148464 1874752..1875267 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1875267 ydhM 7148464 ydhM Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402879.1 1874752 D 585055 CDS YP_002402880.1 218695213 7148465 1875304..1876401 1 NC_011748.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1876401 nemA 7148465 nemA Escherichia coli 55989 N-ethylmaleimide reductase YP_002402880.1 1875304 D 585055 CDS YP_002402881.1 218695214 7146984 1876482..1876889 1 NC_011748.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1876889 gloA 7146984 gloA Escherichia coli 55989 glyoxalase I YP_002402881.1 1876482 D 585055 CDS YP_002402882.1 218695215 7146313 1876992..1877639 1 NC_011748.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1877639 rnt 7146313 rnt Escherichia coli 55989 ribonuclease T YP_002402882.1 1876992 D 585055 CDS YP_002402883.1 218695216 7147456 1877732..1882348 1 NC_011748.1 similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli; ATP-dependent helicase Lhr 1882348 lhr 7147456 lhr Escherichia coli 55989 ATP-dependent helicase Lhr YP_002402883.1 1877732 D 585055 CDS YP_002402884.1 218695217 7146699 complement(1882399..1882746) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15833738, 15840565, 11950925, 12730244; Product type e : enzyme; hypothetical protein 1882746 ydhD 7146699 ydhD Escherichia coli 55989 hypothetical protein YP_002402884.1 1882399 R 585055 CDS YP_002402885.1 218695218 7148459 1883080..1883895 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase 1883895 ydhO 7148459 ydhO Escherichia coli 55989 hydrolase YP_002402885.1 1883080 D 585055 CDS YP_002402886.1 218695219 7148466 1884023..1884604 1 NC_011748.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1884604 sodB 7148466 sodB Escherichia coli 55989 superoxide dismutase YP_002402886.1 1884023 D 585055 CDS YP_002402887.1 218695220 7147672 complement(1884750..1885919) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; efflux protein; MFS family 1885919 ydhP 7147672 ydhP Escherichia coli 55989 efflux protein; MFS family YP_002402887.1 1884750 R 585055 CDS YP_002402888.1 218695221 7148467 1886473..1887498 1 NC_011748.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1887498 purR 7148467 purR Escherichia coli 55989 DNA-binding transcriptional repressor PurR YP_002402888.1 1886473 D 585055 CDS YP_002402889.1 218695222 7147303 complement(1887495..1888427) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404765; Product type pr : regulator; DNA-binding transcriptional regulator 1888427 ydhB 7147303 ydhB Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402889.1 1887495 R 585055 CDS YP_002402890.1 218695223 7148457 1888540..1889751 1 NC_011748.1 uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1889751 ydhC 7148457 ydhC Escherichia coli 55989 inner membrane transport protein YdhC YP_002402890.1 1888540 D 585055 CDS YP_002402891.1 218695224 7148458 1890042..1891190 1 NC_011748.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane-fatty-acyl-phospholipid synthase 1891190 cfa 7148458 cfa Escherichia coli 55989 cyclopropane-fatty-acyl-phospholipid synthase YP_002402891.1 1890042 D 585055 CDS YP_002402892.1 218695225 7145687 complement(1891230..1891871) 1 NC_011748.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha 1891871 ribC 7145687 ribC Escherichia coli 55989 riboflavin synthase subunit alpha YP_002402892.1 1891230 R 585055 CDS YP_002402893.1 218695226 7147411 1892086..1893459 1 NC_011748.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1893459 mdtK 7147411 mdtK Escherichia coli 55989 multidrug efflux protein YP_002402893.1 1892086 D 585055 CDS YP_002402894.1 218695227 7146812 complement(1893500..1894756) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1894756 ydhQ 7146812 ydhQ Escherichia coli 55989 hypothetical protein YP_002402894.1 1893500 R 585055 CDS YP_002402895.1 218695228 7145330 1895329..1895634 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1895634 ydhR 7145330 ydhR Escherichia coli 55989 hypothetical protein YP_002402895.1 1895329 D 585055 CDS YP_002402896.1 218695229 7148469 1895760..1897364 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1897364 ydhS 7148469 ydhS Escherichia coli 55989 hypothetical protein YP_002402896.1 1895760 D 585055 CDS YP_002402897.1 218695230 7148470 complement(1897376..1898188) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1898188 ydhT 7148470 ydhT Escherichia coli 55989 hypothetical protein YP_002402897.1 1897376 R 585055 CDS YP_002402898.1 218695231 7148471 complement(1898192..1898977) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; cytochrome b subunit of a reductase 1898977 ydhU 7148471 ydhU Escherichia coli 55989 cytochrome b subunit of a reductase YP_002402898.1 1898192 R 585055 CDS YP_002402899.1 218695232 7148472 complement(1898974..1899642) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; 4Fe-4S ferredoxin 1899642 ydhX 7148472 ydhX Escherichia coli 55989 4Fe-4S ferredoxin YP_002402899.1 1898974 R 585055 CDS YP_002402900.1 218695233 7148475 complement(1899706..1900353) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1900353 ydhW 7148475 ydhW Escherichia coli 55989 hypothetical protein YP_002402900.1 1899706 R 585055 CDS YP_002402901.1 218695234 7148474 complement(1900357..1902459) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase 1902459 ydhV 7148474 ydhV Escherichia coli 55989 oxidoreductase YP_002402901.1 1900357 R 585055 CDS YP_002402902.1 218695235 7148473 complement(1902480..1903106) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; hypothetical protein 1903106 ydhY 7148473 ydhY Escherichia coli 55989 hypothetical protein YP_002402902.1 1902480 R 585055 CDS YP_002402903.1 218695236 7148476 complement(1903562..1903771) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1903771 ydhZ 7148476 ydhZ Escherichia coli 55989 hypothetical protein YP_002402903.1 1903562 R 585055 CDS YP_002402904.1 218695237 7148477 1904328..1905740 1 NC_011748.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1905740 pykF 7148477 pykF Escherichia coli 55989 pyruvate kinase YP_002402904.1 1904328 D 585055 CDS YP_002402905.1 218695238 7147316 1906051..1906287 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 334727, 338599, 322142, 353292, 391404, 4261992, 4575979, 6765942; Product type lp : lipoprotein; murein lipoprotein 1906287 lpp 7147316 lpp Escherichia coli 55989 murein lipoprotein YP_002402905.1 1906051 D 585055 CDS YP_002402906.1 218695239 7146732 complement(1906351..1907355) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1907355 ynhG 7146732 ynhG Escherichia coli 55989 hypothetical protein YP_002402906.1 1906351 R 585055 CDS YP_002402907.1 218695240 7149323 complement(1907504..1907920) 1 NC_011748.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE 1907920 sufE 7149323 sufE Escherichia coli 55989 cysteine desufuration protein SufE YP_002402907.1 1907504 R 585055 CDS YP_002402908.1 218695241 7147734 complement(1907933..1909153) 1 NC_011748.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase 1909153 sufS 7147734 sufS Escherichia coli 55989 bifunctional cysteine desulfurase/selenocysteine lyase YP_002402908.1 1907933 R 585055 CDS YP_002402909.1 218695242 7147736 complement(1909150..1910421) 1 NC_011748.1 with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD 1910421 sufD 7147736 sufD Escherichia coli 55989 cysteine desulfurase activator complex subunit SufD YP_002402909.1 1909150 R 585055 CDS YP_002402910.1 218695243 7147733 complement(1910396..1911142) 1 NC_011748.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase 1911142 sufC 7147733 sufC Escherichia coli 55989 cysteine desulfurase YP_002402910.1 1910396 R 585055 CDS YP_002402911.1 218695244 7147732 complement(1911152..1912639) 1 NC_011748.1 with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB 1912639 sufB 7147732 sufB Escherichia coli 55989 cysteine desulfurase activator complex subunit SufB YP_002402911.1 1911152 R 585055 CDS YP_002402912.1 218695245 7147731 complement(1912648..1913016) 1 NC_011748.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein 1913016 sufA 7147731 sufA Escherichia coli 55989 iron-sulfur cluster assembly scaffold protein YP_002402912.1 1912648 R 585055 CDS YP_002402913.1 218695246 7147576 complement(1913565..1913834) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1913834 ydiH 7147576 ydiH Escherichia coli 55989 hypothetical protein YP_002402913.1 1913565 R 585055 CDS YP_002402914.1 218695247 7148483 complement(1913853..1914263) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : enzyme; hypothetical protein 1914263 ydiI 7148483 ydiI Escherichia coli 55989 hypothetical protein YP_002402914.1 1913853 R 585055 CDS YP_002402915.1 218695248 7148484 complement(1914260..1917316) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11102686; Product type pe : enzyme; FAD-linked oxidoreductase 1917316 ydiJ 7148484 ydiJ Escherichia coli 55989 FAD-linked oxidoreductase YP_002402915.1 1914260 R 585055 CDS YP_002402916.1 218695249 7148485 1917705..1918817 1 NC_011748.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; inner membrane protein 1918817 ydiK 7148485 ydiK Escherichia coli 55989 inner membrane protein YP_002402916.1 1917705 D 585055 CDS YP_002402917.1 218695250 7147504 1919246..1919602 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1919602 ydiL 7147504 ydiL Escherichia coli 55989 hypothetical protein YP_002402917.1 1919246 D 585055 CDS YP_002402918.1 218695251 7148487 1919702..1920916 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter; MFS superfamily 1920916 ydiM 7148487 ydiM Escherichia coli 55989 transporter; MFS superfamily YP_002402918.1 1919702 D 585055 CDS YP_002402919.1 218695252 7148488 1921143..1922408 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 1922408 ydiN 7148488 ydiN Escherichia coli 55989 transporter YP_002402919.1 1921143 D 585055 CDS YP_002402920.1 218695253 7148489 1922420..1923286 1 NC_011748.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1923286 ydiB 7148489 ydiB Escherichia coli 55989 quinate/shikimate dehydrogenase YP_002402920.1 1922420 D 585055 CDS YP_002402921.1 218695254 7148479 1923317..1924075 1 NC_011748.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1924075 aroD 7148479 aroD Escherichia coli 55989 3-dehydroquinate dehydratase YP_002402921.1 1923317 D 585055 CDS YP_002402922.1 218695255 7145542 1924219..1925814 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16253988; Product type e : enzyme; short chain acyl-CoA transferase: fused alpha subunit ; beta subunit 1925814 ydiF 7145542 ydiF Escherichia coli 55989 short chain acyl-CoA transferase: fused alpha subunit ; beta subunit YP_002402922.1 1924219 D 585055 CDS YP_002402923.1 218695256 7148482 1925828..1926979 1 NC_011748.1 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; acyl-CoA dehydrogenase 1926979 ydiO 7148482 ydiO Escherichia coli 55989 acyl-CoA dehydrogenase YP_002402923.1 1925828 D 585055 CDS YP_002402924.1 218695257 7148490 complement(1927022..1927933) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1927933 ydiP 7148490 ydiP Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402924.1 1927022 R 585055 CDS YP_002402925.1 218695258 7148491 complement(1928036..1928212) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1928212 7148491 EC55989_1864 Escherichia coli 55989 hypothetical protein YP_002402925.1 1928036 R 585055 CDS YP_002402926.1 218695259 7144669 1928249..1929013 1 NC_011748.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; electron transfer flavoprotein YdiQ 1929013 ydiQ 7144669 ydiQ Escherichia coli 55989 electron transfer flavoprotein YdiQ YP_002402926.1 1928249 D 585055 CDS YP_002402927.1 218695260 7148492 1929033..1929971 1 NC_011748.1 May play a role in a redox process; electron transfer flavoprotein subunit YdiR 1929971 ydiR 7148492 ydiR Escherichia coli 55989 electron transfer flavoprotein subunit YdiR YP_002402927.1 1929033 D 585055 CDS YP_002402928.1 218695261 7148493 1930027..1931316 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; hypothetical protein 1931316 ydiS 7148493 ydiS Escherichia coli 55989 hypothetical protein YP_002402928.1 1930027 D 585055 CDS YP_002402929.1 218695262 7148494 1931313..1931606 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; 4Fe-4S ferredoxin 1931606 ydiT 7148494 ydiT Escherichia coli 55989 4Fe-4S ferredoxin YP_002402929.1 1931313 D 585055 CDS YP_002402930.1 218695263 7148495 1931609..1933309 1 NC_011748.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 1933309 ydiD 7148495 ydiD Escherichia coli 55989 short chain acyl-CoA synthetase YP_002402930.1 1931609 D 585055 CDS YP_002402931.1 218695264 7148480 complement(1933366..1935744) 1 NC_011748.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase 1935744 pps 7148480 pps Escherichia coli 55989 phosphoenolpyruvate synthase YP_002402931.1 1933366 R 585055 CDS YP_002402932.1 218695265 7147234 1936077..1936910 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1936910 ydiA 7147234 ydiA Escherichia coli 55989 hypothetical protein YP_002402932.1 1936077 D 585055 CDS YP_002402933.1 218695266 7148478 1937067..1938113 1 NC_011748.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1938113 aroH 7148478 aroH Escherichia coli 55989 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002402933.1 1937067 D 585055 CDS YP_002402934.1 218695267 7145546 1938245..1938436 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15039350; hypothetical protein 1938436 ydiE 7145546 ydiE Escherichia coli 55989 hypothetical protein YP_002402934.1 1938245 D 585055 CDS YP_002402935.1 218695268 7148481 complement(1938440..1939876) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1939876 ydiU 7148481 ydiU Escherichia coli 55989 hypothetical protein YP_002402935.1 1938440 R 585055 CDS YP_002402936.1 218695269 7148496 complement(1939939..1940652) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1940652 ydiV 7148496 ydiV Escherichia coli 55989 hypothetical protein YP_002402936.1 1939939 R 585055 CDS YP_002402937.1 218695270 7148497 complement(1940899..1941363) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12620121; Product type lp : lipoprotein; peptidase lipoprotein 1941363 nlpC 7148497 nlpC Escherichia coli 55989 peptidase lipoprotein YP_002402937.1 1940899 R 585055 CDS YP_002402938.1 218695271 7147008 complement(1941441..1942190) 1 NC_011748.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase 1942190 btuD 7147008 btuD Escherichia coli 55989 vitamin B12-transporter ATPase YP_002402938.1 1941441 R 585055 CDS YP_002402939.1 218695272 7145641 complement(1942190..1942741) 1 NC_011748.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; glutathione peroxidase 1942741 btuE 7145641 btuE Escherichia coli 55989 glutathione peroxidase YP_002402939.1 1942190 R 585055 CDS YP_002402940.1 218695273 7145642 complement(1942804..1943784) 1 NC_011748.1 with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease 1943784 btuC 7145642 btuC Escherichia coli 55989 vtamin B12-transporter permease YP_002402940.1 1942804 R 585055 CDS YP_002402941.1 218695274 7145640 complement(1943885..1944184) 1 NC_011748.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha 1944184 ihfA 7145640 ihfA Escherichia coli 55989 integration host factor subunit alpha YP_002402941.1 1943885 R 585055 CDS YP_002402942.1 218695275 7146546 complement(1944189..1946576) 1 NC_011748.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta 1946576 pheT 7146546 pheT Escherichia coli 55989 phenylalanyl-tRNA synthetase subunit beta YP_002402942.1 1944189 R 585055 CDS YP_002402943.1 218695276 7147162 complement(1946591..1947574) 1 NC_011748.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha 1947574 pheS 7147162 pheS Escherichia coli 55989 phenylalanyl-tRNA synthetase subunit alpha YP_002402943.1 1946591 R 585055 CDS YP_002402945.1 218695278 7147159 complement(1948024..1948380) 1 NC_011748.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 1948380 rplT 7147159 rplT Escherichia coli 55989 50S ribosomal protein L20 YP_002402945.1 1948024 R 585055 CDS YP_002402946.1 218695279 7147480 complement(1948433..1948630) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93085722, 10094780, 3298224, 3542048, 6325158; Product type s : structure; 50S ribosomal protein L35 1948630 rpmI 7147480 rpmI Escherichia coli 55989 50S ribosomal protein L35 YP_002402946.1 1948433 R 585055 CDS YP_002402947.1 218695280 7146567 complement(1949273..1951201) 1 NC_011748.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase 1951201 thrS 7146567 thrS Escherichia coli 55989 threonyl-tRNA synthetase YP_002402947.1 1949273 R 585055 CDS YP_002402948.1 218695281 7144671 complement(1953959..1954717) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1954717 ydiY 7144671 ydiY Escherichia coli 55989 hypothetical protein YP_002402948.1 1953959 R 585055 CDS YP_002402949.1 218695282 7148498 1955004..1955933 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 78194149, 88292964, 6235149, 6310120; Product type e : enzyme; 6-phosphofructokinase 1955933 pfkB 7148498 pfkB Escherichia coli 55989 6-phosphofructokinase YP_002402949.1 1955004 D 585055 CDS YP_002402950.1 218695283 7147140 1956034..1956324 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1956324 ydiZ 7147140 ydiZ Escherichia coli 55989 hypothetical protein YP_002402950.1 1956034 D 585055 CDS YP_002402951.1 218695284 7148499 1956430..1957290 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; phosphotransferase/kinase 1957290 yniA 7148499 yniA Escherichia coli 55989 phosphotransferase/kinase YP_002402951.1 1956430 D 585055 CDS YP_002402952.1 218695285 7149324 complement(1957331..1957867) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1957867 yniB 7149324 yniB Escherichia coli 55989 inner membrane protein YP_002402952.1 1957331 R 585055 CDS YP_002402953.1 218695286 7149325 1958014..1958682 1 NC_011748.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 1958682 yniC 7149325 yniC Escherichia coli 55989 2-deoxyglucose-6-phosphatase YP_002402953.1 1958014 D 585055 CDS YP_002402954.1 218695287 7149326 1958845..1959435 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10760155; Product type pm : membrane component; hypothetical protein 1959435 ydjM 7149326 ydjM Escherichia coli 55989 hypothetical protein YP_002402954.1 1958845 D 585055 CDS YP_002402955.1 218695288 7148509 1959568..1960959 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; cation-acid symporter 1960959 ydjN 7148509 ydjN Escherichia coli 55989 cation-acid symporter YP_002402955.1 1959568 D 585055 CDS YP_002402956.1 218695289 7148512 complement(1962055..1962318) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9427399; Product type cp : cell process; cell division modulator 1962318 cedA 7148512 cedA Escherichia coli 55989 cell division modulator YP_002402956.1 1962055 R 585055 CDS YP_002402957.1 218695290 7145686 1962501..1964762 1 NC_011748.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 1964762 katE 7145686 katE Escherichia coli 55989 hydroperoxidase II YP_002402957.1 1962501 D 585055 CDS YP_002402958.1 218695291 7146645 complement(1964809..1965567) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20042356, 1987146, 2179047, 8121401, 9405618; hypothetical protein 1965567 chbG 7146645 chbG Escherichia coli 55989 hypothetical protein YP_002402958.1 1964809 R 585055 CDS YP_002402959.1 218695292 7145695 complement(1965580..1966932) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042356, 90185127, 9405618; Product type e : enzyme; cryptic phospho-beta-glucosidase, NAD(P)-binding 1966932 chbF 7145695 chbF Escherichia coli 55989 cryptic phospho-beta-glucosidase, NAD(P)-binding YP_002402959.1 1965580 R 585055 CDS YP_002402960.1 218695293 7145694 complement(1967037..1967879) 1 NC_011748.1 represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR 1967879 chbR 7145694 chbR Escherichia coli 55989 DNA-binding transcriptional regulator ChbR YP_002402960.1 1967037 R 585055 CDS YP_002402961.1 218695294 7145696 complement(1967887..1968237) 1 NC_011748.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA 1968237 chbA 7145696 chbA Escherichia coli 55989 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA YP_002402961.1 1967887 R 585055 CDS YP_002402962.1 218695295 7145691 complement(1968288..1969646) 1 NC_011748.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC 1969646 chbC 7145691 chbC Escherichia coli 55989 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC YP_002402962.1 1968288 R 585055 CDS YP_002402963.1 218695296 7145693 complement(1969731..1970051) 1 NC_011748.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB 1970051 chbB 7145693 chbB Escherichia coli 55989 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB YP_002402963.1 1969731 R 585055 CDS YP_002402964.1 218695297 7145692 complement(1970350..1970688) 1 NC_011748.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE 1970688 osmE 7145692 osmE Escherichia coli 55989 DNA-binding transcriptional activator OsmE YP_002402964.1 1970350 R 585055 CDS YP_002402965.1 218695298 7147083 1970890..1971717 1 NC_011748.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1971717 nadE 7147083 nadE Escherichia coli 55989 NAD synthetase YP_002402965.1 1970890 D 585055 CDS YP_002402966.1 218695299 7146946 1971947..1972834 1 NC_011748.1 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1972834 ydjQ 7146946 ydjQ Escherichia coli 55989 nucleotide excision repair endonuclease YP_002402966.1 1971947 D 585055 CDS YP_002402967.1 218695300 7148513 complement(1972794..1973369) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21862596; hypothetical protein 1973369 ydjR 7148513 ydjR Escherichia coli 55989 hypothetical protein YP_002402967.1 1972794 R 585055 CDS YP_002402968.1 218695301 7148514 complement(1973572..1974057) 1 NC_011748.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; hypothetical protein 1974057 spy 7148514 spy Escherichia coli 55989 hypothetical protein YP_002402968.1 1973572 R 585055 CDS YP_002402969.1 218695302 7147697 complement(1974387..1975355) 1 NC_011748.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase 1975355 astE 7147697 astE Escherichia coli 55989 succinylglutamate desuccinylase YP_002402969.1 1974387 R 585055 CDS YP_002402970.1 218695303 7145579 complement(1975348..1976691) 1 NC_011748.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase 1976691 astB 7145579 astB Escherichia coli 55989 succinylarginine dihydrolase YP_002402970.1 1975348 R 585055 CDS YP_002402971.1 218695304 7145576 complement(1976688..1978166) 1 NC_011748.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase 1978166 astD 7145576 astD Escherichia coli 55989 succinylglutamic semialdehyde dehydrogenase YP_002402971.1 1976688 R 585055 CDS YP_002402972.1 218695305 7145578 complement(1978163..1979197) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14675764, 98361920; Product type e : enzyme; arginine succinyltransferase 1979197 astA 7145578 astA Escherichia coli 55989 arginine succinyltransferase YP_002402972.1 1978163 R 585055 CDS YP_002402973.1 218695306 7145575 complement(1979194..1980414) 1 NC_011748.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase 1980414 astC 7145575 astC Escherichia coli 55989 bifunctional succinylornithine transaminase/acetylornithine transaminase YP_002402973.1 1979194 R 585055 CDS YP_002402974.1 218695307 7145577 1980860..1981666 1 NC_011748.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1981666 xthA 7145577 xthA Escherichia coli 55989 exonuclease III YP_002402974.1 1980860 D 585055 CDS YP_002402975.1 218695308 7147994 1981833..1982543 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1982543 ydjX 7147994 ydjX Escherichia coli 55989 inner membrane protein YP_002402975.1 1981833 D 585055 CDS YP_002402976.1 218695309 7148515 1982548..1983225 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1983225 ydjY 7148515 ydjY Escherichia coli 55989 hypothetical protein YP_002402976.1 1982548 D 585055 CDS YP_002402977.1 218695310 7148516 1983239..1983946 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1983946 ydjZ 7148516 ydjZ Escherichia coli 55989 inner membrane protein YP_002402977.1 1983239 D 585055 CDS YP_002402978.1 218695311 7148517 1983946..1984494 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1984494 ynjA 7148517 ynjA Escherichia coli 55989 hypothetical protein YP_002402978.1 1983946 D 585055 CDS YP_002402979.1 218695312 7149327 1984504..1985670 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; ABC transporter substrate-binding protein 1985670 ynjB 7149327 ynjB Escherichia coli 55989 ABC transporter substrate-binding protein YP_002402979.1 1984504 D 585055 CDS YP_002402980.1 218695313 7149328 1985688..1987178 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; fused transporter subunits of ABC superfamily: membrane components 1987178 ynjC 7149328 ynjC Escherichia coli 55989 fused transporter subunits of ABC superfamily: membrane components YP_002402980.1 1985688 D 585055 CDS YP_002402981.1 218695314 7149329 1987178..1987831 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sulfate/thiosulfate transporter subunit: ATP-binding component of ABC superfamily transporter 1987831 ynjD 7149329 ynjD Escherichia coli 55989 sulfate/thiosulfate transporter subunit: ATP-binding component of ABC superfamily transporter YP_002402981.1 1987178 D 585055 CDS YP_002402982.1 218695315 7149330 1987898..1989205 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; thiosulfate sulfur transferase / thiosulfate binding protein 1989205 ynjE 7149330 ynjE Escherichia coli 55989 thiosulfate sulfur transferase / thiosulfate binding protein YP_002402982.1 1987898 D 585055 CDS YP_002402983.1 218695316 7149331 complement(1989214..1989834) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type m : membrane component; phosphatidyl transferase, inner membrane protein 1989834 ynjF 7149331 ynjF Escherichia coli 55989 phosphatidyl transferase, inner membrane protein YP_002402983.1 1989214 R 585055 CDS YP_002402984.1 218695317 7149332 1989921..1990328 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101911; Product type e : enzyme; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1990328 nudG 7149332 nudG Escherichia coli 55989 pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase YP_002402984.1 1989921 D 585055 CDS YP_002402985.1 218695318 7147041 1990802..1992145 1 NC_011748.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1992145 gdhA 7147041 gdhA Escherichia coli 55989 glutamate dehydrogenase YP_002402985.1 1990802 D 585055 CDS YP_002402986.1 218695319 7146280 complement(1992262..1993302) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 1993302 ynjI 7146280 ynjI Escherichia coli 55989 hypothetical protein YP_002402986.1 1992262 R 585055 CDS YP_002402987.1 218695320 7149333 complement(1993430..1995391) 1 NC_011748.1 decatenates replicating daughter chromosomes; DNA topoisomerase III 1995391 topB 7149333 topB Escherichia coli 55989 DNA topoisomerase III YP_002402987.1 1993430 R 585055 CDS YP_002402988.1 218695321 7147819 complement(1995396..1996439) 1 NC_011748.1 catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase 1996439 selD 7147819 selD Escherichia coli 55989 selenophosphate synthetase YP_002402988.1 1995396 R 585055 CDS YP_002402989.1 218695322 7147630 complement(1996381..1996530) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1996530 7147630 EC55989_1932 Escherichia coli 55989 hypothetical protein YP_002402989.1 1996381 R 585055 CDS YP_002402990.1 218695323 7144672 complement(1996556..1997107) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 1997107 ydjA 7144672 ydjA Escherichia coli 55989 hypothetical protein YP_002402990.1 1996556 R 585055 CDS YP_002402991.1 218695324 7148500 1997161..1997325 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1997325 7148500 EC55989_1934 Escherichia coli 55989 hypothetical protein YP_002402991.1 1997161 D 585055 CDS YP_002402992.1 218695325 7144673 1997268..1999124 1 NC_011748.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1999124 sppA 7144673 sppA Escherichia coli 55989 protease 4 YP_002402992.1 1997268 D 585055 CDS YP_002402993.1 218695326 7147694 1999291..2000307 1 NC_011748.1 converts asparagine to aspartate and ammonia; asparaginase 2000307 ansA 7147694 ansA Escherichia coli 55989 asparaginase YP_002402993.1 1999291 D 585055 CDS YP_002402994.1 218695327 7145502 2000318..2000959 1 NC_011748.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 2000959 pncA 7145502 pncA Escherichia coli 55989 nicotinamidase/pyrazinamidase YP_002402994.1 2000318 D 585055 CDS YP_002402995.1 218695328 7147201 complement(2001052..2002410) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter; MFS superfamily 2002410 ydjE 7147201 ydjE Escherichia coli 55989 transporter; MFS superfamily YP_002402995.1 2001052 R 585055 CDS YP_002402996.1 218695329 7148501 complement(2002527..2003285) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 2003285 ydjF 7148501 ydjF Escherichia coli 55989 DNA-binding transcriptional regulator YP_002402996.1 2002527 R 585055 CDS YP_002402997.1 218695330 7148502 complement(2003422..2004402) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase 2004402 ydjG 7148502 ydjG Escherichia coli 55989 oxidoreductase YP_002402997.1 2003422 R 585055 CDS YP_002402998.1 218695331 7148503 complement(2004412..2005359) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; sugar kinase 2005359 ydjH 7148503 ydjH Escherichia coli 55989 sugar kinase YP_002402998.1 2004412 R 585055 CDS YP_002402999.1 218695332 7148504 complement(2005364..2006200) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; aldolase 2006200 ydjI 7148504 ydjI Escherichia coli 55989 aldolase YP_002402999.1 2005364 R 585055 CDS YP_002403000.1 218695333 7148505 complement(2006221..2007198) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12897001; Product type pe : enzyme; iditol dehydrogenase 2007198 ydjJ 7148505 ydjJ Escherichia coli 55989 iditol dehydrogenase YP_002403000.1 2006221 R 585055 CDS YP_002403001.1 218695334 7148506 complement(2007280..2008659) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter; MFS superfamily 2008659 ydjK 7148506 ydjK Escherichia coli 55989 transporter; MFS superfamily YP_002403001.1 2007280 R 585055 CDS YP_002403002.1 218695335 7148507 complement(2008686..2009762) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase, Zn-dependent and NAD(P)-binding 2009762 ydjL 7148507 ydjL Escherichia coli 55989 oxidoreductase, Zn-dependent and NAD(P)-binding YP_002403002.1 2008686 R 585055 CDS YP_002403003.1 218695336 7148508 complement(2010132..2010404) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2010404 yeaC 7148508 yeaC Escherichia coli 55989 hypothetical protein YP_002403003.1 2010132 R 585055 CDS YP_002403004.1 218695337 7148519 complement(2010446..2010859) 1 NC_011748.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B 2010859 msrB 7148519 msrB Escherichia coli 55989 methionine sulfoxide reductase B YP_002403004.1 2010446 R 585055 CDS YP_002403005.1 218695338 7146911 2011201..2012196 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 775311, 94131963, 98361923, 1862091, 2124629, 2990926, 7896119, 8636984, 9298646; Product type e : enzyme; glyceraldehyde-3-phosphate dehydrogenase 2012196 gapA 7146911 gapA Escherichia coli 55989 glyceraldehyde-3-phosphate dehydrogenase YP_002403005.1 2011201 D 585055 CDS YP_002403006.1 218695339 7146256 2012280..2013164 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2013164 yeaD 7146256 yeaD Escherichia coli 55989 hypothetical protein YP_002403006.1 2012280 D 585055 CDS YP_002403007.1 218695340 7148520 complement(2013215..2014069) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase 2014069 yeaE 7148520 yeaE Escherichia coli 55989 oxidoreductase YP_002403007.1 2013215 R 585055 CDS YP_002403008.1 218695341 7148521 complement(2014159..2014905) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10037771, 20267815; Product type f : factor; scaffolding protein for murein synthesizing machinery 2014905 mipA 7148521 mipA Escherichia coli 55989 scaffolding protein for murein synthesizing machinery YP_002403008.1 2014159 R 585055 CDS YP_002403009.1 218695342 7146861 2015341..2017275 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; nucleoside triphosphate hydrolase domain 2017275 yeaG 7146861 yeaG Escherichia coli 55989 nucleoside triphosphate hydrolase domain YP_002403009.1 2015341 D 585055 CDS YP_002403010.1 218695343 7148522 2017388..2018671 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2018671 yeaH 7148522 yeaH Escherichia coli 55989 hypothetical protein YP_002403010.1 2017388 D 585055 CDS YP_002403011.1 218695344 7148523 2018818..2020293 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; diguanylate cyclase 2020293 yeaI 7148523 yeaI Escherichia coli 55989 diguanylate cyclase YP_002403011.1 2018818 D 585055 CDS YP_002403012.1 218695345 7148524 2020474..2021964 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; diguanylate cyclase 2021964 yeaJ 7148524 yeaJ Escherichia coli 55989 diguanylate cyclase YP_002403012.1 2020474 D 585055 CDS YP_002403013.1 218695346 7148525 2022007..2022510 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2022510 yeaK 7148525 yeaK Escherichia coli 55989 hypothetical protein YP_002403013.1 2022007 D 585055 CDS YP_002403014.1 218695347 7148526 complement(2022511..2022663) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 2022663 7148526 EC55989_1957 Escherichia coli 55989 hypothetical protein YP_002403014.1 2022511 R 585055 CDS YP_002403015.1 218695348 7144674 2022785..2023231 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2023231 yeaL 7144674 yeaL Escherichia coli 55989 inner membrane protein YP_002403015.1 2022785 D 585055 CDS YP_002403016.1 218695349 7148527 complement(2023188..2024009) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 2024009 yeaM 7148527 yeaM Escherichia coli 55989 DNA-binding transcriptional regulator YP_002403016.1 2023188 R 585055 CDS YP_002403017.1 218695350 7148528 2024106..2025287 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter; MFS superfamily 2025287 yeaN 7148528 yeaN Escherichia coli 55989 transporter; MFS superfamily YP_002403017.1 2024106 D 585055 CDS YP_002403018.1 218695351 7148529 2025342..2025689 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2025689 yeaO 7148529 yeaO Escherichia coli 55989 hypothetical protein YP_002403018.1 2025342 D 585055 CDS YP_002403019.1 218695352 7148530 complement(2025711..2025965) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; outer membrane protein 2025965 yoaF 7148530 yoaF Escherichia coli 55989 outer membrane protein YP_002403019.1 2025711 R 585055 CDS YP_002403020.1 218695353 7149338 2026148..2027173 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; diguanylate cyclase 2027173 yeaP 7149338 yeaP Escherichia coli 55989 diguanylate cyclase YP_002403020.1 2026148 D 585055 CDS YP_002403021.1 218695354 7148531 complement(2027440..2027688) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2027688 yeaQ 7148531 yeaQ Escherichia coli 55989 hypothetical protein YP_002403021.1 2027440 R 585055 CDS YP_002403022.1 218695355 7148532 complement(2027700..2027885) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2027885 7148532 EC55989_1966 Escherichia coli 55989 hypothetical protein YP_002403022.1 2027700 R 585055 CDS YP_002403023.1 218695356 7144675 complement(2027915..2029123) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase 2029123 ydcM 7144675 ydcM Escherichia coli 55989 transposase YP_002403023.1 2027915 R 585055 CDS YP_002403024.1 218695357 7148392 complement(2029101..2029247) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 2029247 7148392 EC55989_1968 Escherichia coli 55989 hypothetical protein YP_002403024.1 2029101 R 585055 CDS YP_002403025.1 218695358 7144676 complement(2029578..2029766) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2029766 7144676 EC55989_1969 Escherichia coli 55989 hypothetical protein YP_002403025.1 2029578 R 585055 CDS YP_002403026.1 218695359 7144677 complement(2029770..2030129) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2030129 yeaR 7144677 yeaR Escherichia coli 55989 hypothetical protein YP_002403026.1 2029770 R 585055 CDS YP_002403027.1 218695360 7148533 complement(2030302..2030940) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; leucine export protein LeuE 2030940 yeaS 7148533 yeaS Escherichia coli 55989 leucine export protein LeuE YP_002403027.1 2030302 R 585055 CDS YP_002403028.1 218695361 7148534 complement(2031067..2031990) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 2031990 yeaT 7148534 yeaT Escherichia coli 55989 DNA-binding transcriptional regulator YP_002403028.1 2031067 R 585055 CDS YP_002403029.1 218695362 7148535 2032093..2033178 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; tartrate dehydrogenase 2033178 yeaU 7148535 yeaU Escherichia coli 55989 tartrate dehydrogenase YP_002403029.1 2032093 D 585055 CDS YP_002403030.1 218695363 7148536 2033594..2035039 1 NC_011748.1 member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; transporter 2035039 yeaV 7148536 yeaV Escherichia coli 55989 transporter YP_002403030.1 2033594 D 585055 CDS YP_002403031.1 218695364 7148537 2035071..2036195 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; 2Fe-2S cluster-containing dioxygenase subunit 2036195 yeaW 7148537 yeaW Escherichia coli 55989 2Fe-2S cluster-containing dioxygenase subunit YP_002403031.1 2035071 D 585055 CDS YP_002403032.1 218695365 7148538 2036251..2037216 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; dioxygenase subunit 2037216 yeaX 7148538 yeaX Escherichia coli 55989 dioxygenase subunit YP_002403032.1 2036251 D 585055 CDS YP_002403033.1 218695366 7148539 complement(2037270..2038397) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88289400, 89053950, 93015723, 8107670; Product type e : enzyme; ribonuclease D 2038397 rnd 7148539 rnd Escherichia coli 55989 ribonuclease D YP_002403033.1 2037270 R 585055 CDS YP_002403034.1 218695367 7147447 complement(2038467..2040152) 1 NC_011748.1 Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase 2040152 fadD 7147447 fadD Escherichia coli 55989 long-chain-fatty-acid--CoA ligase YP_002403034.1 2038467 R 585055 CDS YP_002403035.1 218695368 7146057 complement(2040357..2040938) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type lp : lipoprotein; outer membrane-associated lipoprotein 2040938 yeaY 7146057 yeaY Escherichia coli 55989 outer membrane-associated lipoprotein YP_002403035.1 2040357 R 585055 CDS YP_002403036.1 218695369 7148540 complement(2040978..2041673) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; peptidase 2041673 yeaZ 7148540 yeaZ Escherichia coli 55989 peptidase YP_002403036.1 2040978 R 585055 CDS YP_002403037.1 218695370 7148541 complement(2041731..2043641) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; ATP-dependent helicase 2043641 yoaA 7148541 yoaA Escherichia coli 55989 ATP-dependent helicase YP_002403037.1 2041731 R 585055 CDS YP_002403038.1 218695371 7149334 2043773..2044117 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2044117 yoaB 7149334 yoaB Escherichia coli 55989 hypothetical protein YP_002403038.1 2043773 D 585055 CDS YP_002403039.1 218695372 7149335 2044480..2044839 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2044839 yoaC 7149335 yoaC Escherichia coli 55989 hypothetical protein YP_002403039.1 2044480 D 585055 CDS YP_002403040.1 218695373 7149336 complement(2044959..2045138) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2045138 yoaH 7149336 yoaH Escherichia coli 55989 hypothetical protein YP_002403040.1 2044959 R 585055 CDS YP_002403041.1 218695374 7149339 2045212..2046573 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88025006, 91067712, 91302313, 96011382, 6330050, 7896119; Product type e : enzyme; aminodeoxychorismate synthase subunit I 2046573 pabB 7149339 pabB Escherichia coli 55989 aminodeoxychorismate synthase subunit I YP_002403041.1 2045212 D 585055 CDS YP_002403042.1 218695375 7147107 2046577..2047155 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : enzyme; hypothetical protein 2047155 yeaB 7147107 yeaB Escherichia coli 55989 hypothetical protein YP_002403042.1 2046577 D 585055 CDS YP_002403043.1 218695376 7148518 2047339..2048703 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155761, 89359152, 91056090, 93170282; Product type e : enzyme; L-serine deaminase I 2048703 sdaA 7148518 sdaA Escherichia coli 55989 L-serine deaminase I YP_002403043.1 2047339 D 585055 CDS YP_002403044.1 218695377 7147612 2048834..2050432 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16513732; Product type pe : enzyme; cyclic di-GMP phosphodiesterase 2050432 adrB 7147612 adrB Escherichia coli 55989 cyclic di-GMP phosphodiesterase YP_002403044.1 2048834 D 585055 CDS YP_002403045.1 218695378 7145461 complement(2050436..2051992) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; membrane protein fused with conserved domain 2051992 yoaE 7145461 yoaE Escherichia coli 55989 membrane protein fused with conserved domain YP_002403045.1 2050436 R 585055 CDS YP_002403046.1 218695379 7149337 2052455..2053426 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165962, 90036983, 8131846, 8676384, 9074635, 9298646; Product type t : transporter; fused mannose-specific PTS enzymes: IIA component ; IIB component 2053426 manX 7149337 manX Escherichia coli 55989 fused mannose-specific PTS enzymes: IIA component ; IIB component YP_002403046.1 2052455 D 585055 CDS YP_002403047.1 218695380 7146782 2053489..2054289 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 87165962, 90036983, 94086520, 97128775, 7811395, 8774730; Product type t : transporter; mannose-specific enzyme IIC component of PTS 2054289 manY 7146782 manY Escherichia coli 55989 mannose-specific enzyme IIC component of PTS YP_002403047.1 2053489 D 585055 CDS YP_002403048.1 218695381 7146783 2054293..2055153 1 NC_011748.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 2055153 manZ 7146783 manZ Escherichia coli 55989 PTS system mannose-specific transporter subunit IID YP_002403048.1 2054293 D 585055 CDS YP_002403049.1 218695382 7146784 2055208..2055666 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2055666 yobD 7146784 yobD Escherichia coli 55989 hypothetical protein YP_002403049.1 2055208 D 585055 CDS YP_002403050.1 218695383 7149342 2055853..2056098 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 2056098 7149342 EC55989_1994 Escherichia coli 55989 hypothetical protein YP_002403050.1 2055853 D 585055 CDS YP_002403051.1 218695384 7144678 2056095..2056661 1 NC_011748.1 membrane protein YebN; hypothetical protein 2056661 yebN 7144678 yebN Escherichia coli 55989 hypothetical protein YP_002403051.1 2056095 D 585055 CDS YP_002403052.1 218695385 7148549 complement(2056658..2057467) 1 NC_011748.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase 2057467 rrmA 7148549 rrmA Escherichia coli 55989 23S rRNA methyltransferase YP_002403052.1 2056658 R 585055 CDS YP_002403053.1 218695386 7147527 complement(2057633..2057842) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 21101802, 94293754, 12071744, 7984109, 8022261, 9298646, 9868784, 9921691; Product type f : factor; cold shock-like protein CspC 2057842 cspC 7147527 cspC Escherichia coli 55989 cold shock-like protein CspC YP_002403053.1 2057633 R 585055 CDS YP_002403054.1 218695387 7145778 complement(2057855..2057998) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2057998 yobF 7145778 yobF Escherichia coli 55989 hypothetical protein YP_002403054.1 2057855 R 585055 CDS YP_002403055.1 218695388 7149343 complement(2058668..2058955) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2058955 yebO 7149343 yebO Escherichia coli 55989 hypothetical protein YP_002403055.1 2058668 R 585055 CDS YP_002403056.1 218695389 7148550 complement(2059030..2059173) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2059173 yobG 7148550 yobG Escherichia coli 55989 hypothetical protein YP_002403056.1 2059030 R 585055 CDS YP_002403057.1 218695390 7149344 2059332..2059571 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2059571 yobH 7149344 yobH Escherichia coli 55989 hypothetical protein YP_002403057.1 2059332 D 585055 CDS YP_002403058.1 218695391 7149345 2059868..2060143 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 2060143 insA 7149345 insA Escherichia coli 55989 IS1 repressor protein InsA YP_002403058.1 2059868 D 585055 CDS YP_002403059.1 218695392 7146575 2060062..2060565 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 2060565 insB 7146575 insB Escherichia coli 55989 IS1 transposase InsAB' YP_002403059.1 2060062 D 585055 CDS YP_002403060.1 218695393 7146587 complement(2060500..2061282) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659677, 4359651; Product type r : regulator; DNA-binding transcriptional repressor KdgR 2061282 kdgR 7146587 kdgR Escherichia coli 55989 DNA-binding transcriptional repressor KdgR YP_002403060.1 2060500 R 585055 CDS YP_002403061.1 218695394 7146652 2061459..2062832 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter; MFS superfamily 2062832 yebQ 7146652 yebQ Escherichia coli 55989 transporter; MFS superfamily YP_002403061.1 2061459 D 585055 CDS YP_002403062.1 218695395 7148551 complement(2062878..2063759) 1 NC_011748.1 metalloprotease; heat shock protein HtpX 2063759 htpX 7148551 htpX Escherichia coli 55989 heat shock protein HtpX YP_002403062.1 2062878 R 585055 CDS YP_002403063.1 218695396 7146474 complement(2063951..2065999) 1 NC_011748.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease 2065999 prc 7146474 prc Escherichia coli 55989 carboxy-terminal protease YP_002403063.1 2063951 R 585055 CDS YP_002403064.1 218695397 7147239 complement(2066019..2066717) 1 NC_011748.1 affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector 2066717 proQ 7147239 proQ Escherichia coli 55989 solute/DNA competence effector YP_002403064.1 2066019 R 585055 CDS YP_002403065.1 218695398 7147256 complement(2066814..2067365) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2067365 yebR 7147256 yebR Escherichia coli 55989 hypothetical protein YP_002403065.1 2066814 R 585055 CDS YP_002403066.1 218695399 7148552 2067441..2068724 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2068724 yebS 7148552 yebS Escherichia coli 55989 inner membrane protein YP_002403066.1 2067441 D 585055 CDS YP_002403067.1 218695400 7148553 2068693..2071326 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2071326 yebT 7148553 yebT Escherichia coli 55989 hypothetical protein YP_002403067.1 2068693 D 585055 CDS YP_002403068.1 218695401 7148554 2071406..2072845 1 NC_011748.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 2072845 yebU 7148554 yebU Escherichia coli 55989 rRNA (cytosine-C(5)-)-methyltransferase RsmF YP_002403068.1 2071406 D 585055 CDS YP_002403069.1 218695402 7148555 2072963..2073199 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2073199 yebV 7148555 yebV Escherichia coli 55989 hypothetical protein YP_002403069.1 2072963 D 585055 CDS YP_002403070.1 218695403 7148556 2073220..2073495 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2073495 yebW 7148556 yebW Escherichia coli 55989 hypothetical protein YP_002403070.1 2073220 D 585055 CDS YP_002403071.1 218695404 7148557 complement(2073496..2074152) 1 NC_011748.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 2074152 pphA 7148557 pphA Escherichia coli 55989 serine/threonine protein phosphatase 1 YP_002403071.1 2073496 R 585055 CDS YP_002403072.1 218695405 7144679 complement(2074548..2074889) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2074889 yebY 7144679 yebY Escherichia coli 55989 hypothetical protein YP_002403072.1 2074548 R 585055 CDS YP_002403073.1 218695406 7148558 complement(2074902..2075774) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2075774 yebZ 7148558 yebZ Escherichia coli 55989 inner membrane protein YP_002403073.1 2074902 R 585055 CDS YP_002403074.1 218695407 7148559 complement(2075778..2076152) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2076152 yobA 7148559 yobA Escherichia coli 55989 hypothetical protein YP_002403074.1 2075778 R 585055 CDS YP_002403075.1 218695408 7149340 2076291..2076521 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15090519, 92147649, 92156151, 94131961, 1575709, 8341603, 8505306; Product type e : enzyme; DNA polymerase III subunit theta 2076521 holE 7149340 holE Escherichia coli 55989 DNA polymerase III subunit theta YP_002403075.1 2076291 D 585055 CDS YP_002403076.1 218695409 7146457 2076623..2077279 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2077279 yobB 7146457 yobB Escherichia coli 55989 hypothetical protein YP_002403076.1 2076623 D 585055 CDS YP_002403077.1 218695410 7149341 2077303..2077965 1 NC_011748.1 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 2077965 exoX 7149341 exoX Escherichia coli 55989 exodeoxyribonuclease X YP_002403077.1 2077303 D 585055 CDS YP_002403078.1 218695411 7146043 complement(2077962..2080022) 1 NC_011748.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 2080022 ptrB 7146043 ptrB Escherichia coli 55989 protease 2 YP_002403078.1 2077962 R 585055 CDS YP_002403079.1 218695412 7147284 complement(2080231..2080890) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; inner membrane protein 2080890 yebE 7147284 yebE Escherichia coli 55989 inner membrane protein YP_002403079.1 2080231 R 585055 CDS YP_002403080.1 218695413 7148545 complement(2081217..2081585) 1 NC_011748.1 secreted protein; unknown function; hypothetical protein 2081585 yebF 7148545 yebF Escherichia coli 55989 hypothetical protein YP_002403080.1 2081217 R 585055 CDS YP_002403081.1 218695414 7148546 complement(2081640..2081930) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9368369, 99403401; Product type cp : cell process; DNA damage-inducible protein YebG 2081930 yebG 7148546 yebG Escherichia coli 55989 DNA damage-inducible protein YebG YP_002403081.1 2081640 R 585055 CDS YP_002403082.1 218695415 7148547 2082064..2083242 1 NC_011748.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 2083242 purT 7148547 purT Escherichia coli 55989 phosphoribosylglycinamide formyltransferase 2 YP_002403082.1 2082064 D 585055 CDS YP_002403083.1 218695416 7147304 complement(2083298..2083939) 1 NC_011748.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase 2083939 eda 7147304 eda Escherichia coli 55989 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase YP_002403083.1 2083298 R 585055 CDS YP_002403084.1 218695417 7145976 complement(2083976..2085787) 1 NC_011748.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase 2085787 edd 7145976 edd Escherichia coli 55989 phosphogluconate dehydratase YP_002403084.1 2083976 R 585055 CDS YP_002403085.1 218695418 7145977 complement(2086022..2087497) 1 NC_011748.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase 2087497 zwf 7145977 zwf Escherichia coli 55989 glucose-6-phosphate 1-dehydrogenase YP_002403085.1 2086022 R 585055 CDS YP_002403086.1 218695419 7149500 2087835..2088704 1 NC_011748.1 Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 2088704 yebK 7149500 yebK Escherichia coli 55989 DNA-binding transcriptional regulator HexR YP_002403086.1 2087835 D 585055 CDS YP_002403087.1 218695420 7148548 2088832..2090274 1 NC_011748.1 catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2090274 pykA 7148548 pykA Escherichia coli 55989 pyruvate kinase YP_002403087.1 2088832 D 585055 CDS YP_002403088.1 218695421 7147315 complement(2090405..2091376) 1 NC_011748.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 2091376 lpxM 7147315 lpxM Escherichia coli 55989 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_002403088.1 2090405 R 585055 CDS YP_002403089.1 218695422 7146742 complement(2091496..2092818) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1732206; Product type pe : enzyme; hypothetical protein 2092818 yebA 7146742 yebA Escherichia coli 55989 hypothetical protein YP_002403089.1 2091496 R 585055 CDS YP_002403090.1 218695423 7148542 complement(2092834..2093766) 1 NC_011748.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic protein 2093766 znuA 7148542 znuA Escherichia coli 55989 high-affinity zinc transporter periplasmic protein YP_002403090.1 2092834 R 585055 CDS YP_002403091.1 218695424 7149492 2093845..2094600 1 NC_011748.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 2094600 znuC 7149492 znuC Escherichia coli 55989 high-affinity zinc transporter ATPase YP_002403091.1 2093845 D 585055 CDS YP_002403092.1 218695425 7149494 2094597..2095382 1 NC_011748.1 involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane protein 2095382 znuB 7149494 znuB Escherichia coli 55989 high-affinity zinc transporter membrane protein YP_002403092.1 2094597 D 585055 CDS YP_002403093.1 218695426 7149493 complement(2095529..2096539) 1 NC_011748.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB 2096539 ruvB 7149493 ruvB Escherichia coli 55989 Holliday junction DNA helicase RuvB YP_002403093.1 2095529 R 585055 CDS YP_002403094.1 218695427 7147570 complement(2096548..2097159) 1 NC_011748.1 plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA 2097159 ruvA 7147570 ruvA Escherichia coli 55989 Holliday junction DNA helicase RuvA YP_002403094.1 2096548 R 585055 CDS YP_002403095.1 218695428 7147569 2097434..2098036 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2098036 yebB 7147569 yebB Escherichia coli 55989 hypothetical protein YP_002403095.1 2097434 D 585055 CDS YP_002403096.1 218695429 7148543 complement(2098038..2098559) 1 NC_011748.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase 2098559 ruvC 7148543 ruvC Escherichia coli 55989 Holliday junction resolvase YP_002403096.1 2098038 R 585055 CDS YP_002403097.1 218695430 7147571 complement(2098594..2099334) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2099334 yebC 7147571 yebC Escherichia coli 55989 hypothetical protein YP_002403097.1 2098594 R 585055 CDS YP_002403098.1 218695431 7148544 complement(2099363..2099806) 1 NC_011748.1 converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase 2099806 ntpA 7148544 ntpA Escherichia coli 55989 dATP pyrophosphohydrolase YP_002403098.1 2099363 R 585055 CDS YP_002403099.1 218695432 7147036 complement(2099808..2101580) 1 NC_011748.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase 2101580 aspS 7147036 aspS Escherichia coli 55989 aspartyl-tRNA synthetase YP_002403099.1 2099808 R 585055 CDS YP_002403100.1 218695433 7145573 2101890..2102456 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 2102456 yecD 7145573 yecD Escherichia coli 55989 hypothetical protein YP_002403100.1 2101890 D 585055 CDS YP_002403101.1 218695434 7148562 2102453..2103271 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2129559, 7984428; hypothetical protein 2103271 yecE 7148562 yecE Escherichia coli 55989 hypothetical protein YP_002403101.1 2102453 D 585055 CDS YP_002403102.1 218695435 7148563 2103324..2103719 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2103719 yecN 7148563 yecN Escherichia coli 55989 inner membrane protein YP_002403102.1 2103324 D 585055 CDS YP_002403103.1 218695436 7148570 2103760..2104503 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11746687; Product type e : enzyme; AdoMet-dependent methyltransferase 2104503 yecO 7148570 yecO Escherichia coli 55989 AdoMet-dependent methyltransferase YP_002403103.1 2103760 D 585055 CDS YP_002403104.1 218695437 7148571 2104500..2105471 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2105471 yecP 7148571 yecP Escherichia coli 55989 hypothetical protein YP_002403104.1 2104500 D 585055 CDS YP_002403105.1 218695438 7148572 complement(2105636..2108065) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97077292, 11004177; Product type e : enzyme; trimethylamine N-oxide reductase system III, catalytic subunit 2108065 torZ 7148572 torZ Escherichia coli 55989 trimethylamine N-oxide reductase system III, catalytic subunit YP_002403105.1 2105636 R 585055 CDS YP_002403106.1 218695439 7147828 complement(2108090..2109190) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461225, 8919859; Product type c : carrier; TMAO reductase III (TorYZ), cytochrome c-type subunit 2109190 torY 7147828 torY Escherichia coli 55989 TMAO reductase III (TorYZ), cytochrome c-type subunit YP_002403106.1 2108090 R 585055 CDS YP_002403107.1 218695440 7147827 complement(2109578..2110324) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95362641, 7635807; Product type t : transporter; copper homeostasis protein CutC 2110324 cutC 7147827 cutC Escherichia coli 55989 copper homeostasis protein CutC YP_002403107.1 2109578 R 585055 CDS YP_002403108.1 218695441 7145799 complement(2110338..2110904) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12660999; Product type pe : enzyme; hypothetical protein 2110904 yecM 7145799 yecM Escherichia coli 55989 hypothetical protein YP_002403108.1 2110338 R 585055 CDS YP_002403109.1 218695442 7148569 2111120..2112853 1 NC_011748.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 2112853 argS 7148569 argS Escherichia coli 55989 arginyl-tRNA synthetase YP_002403109.1 2111120 D 585055 CDS YP_002403110.1 218695443 7145536 2113030..2113518 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2113518 yecT 7145536 yecT Escherichia coli 55989 hypothetical protein YP_002403110.1 2113030 D 585055 CDS YP_002403111.1 218695444 7148575 complement(2113638..2114030) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8002587, 1482109, 89181349; hypothetical protein 2114030 flhE 7148575 flhE Escherichia coli 55989 hypothetical protein YP_002403111.1 2113638 R 585055 CDS YP_002403112.1 218695445 7146142 complement(2114030..2116108) 1 NC_011748.1 membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA 2116108 flhA 7146142 flhA Escherichia coli 55989 flagellar biosynthesis protein FlhA YP_002403112.1 2114030 R 585055 CDS YP_002403113.1 218695446 7146138 complement(2116101..2117249) 1 NC_011748.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB 2117249 flhB 7146138 flhB Escherichia coli 55989 flagellar biosynthesis protein FlhB YP_002403113.1 2116101 R 585055 CDS YP_002403114.1 218695447 7146139 complement(2117451..2118095) 1 NC_011748.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ 2118095 cheZ 7146139 cheZ Escherichia coli 55989 chemotaxis regulator CheZ YP_002403114.1 2117451 R 585055 CDS YP_002403115.1 218695448 7145702 complement(2118106..2118495) 1 NC_011748.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY 2118495 cheY 7145702 cheY Escherichia coli 55989 chemotaxis regulatory protein CheY YP_002403115.1 2118106 R 585055 CDS YP_002403116.1 218695449 7145701 complement(2118510..2119559) 1 NC_011748.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase 2119559 cheB 7145701 cheB Escherichia coli 55989 chemotaxis-specific methylesterase YP_002403116.1 2118510 R 585055 CDS YP_002403117.1 218695450 7145698 complement(2119562..2120422) 1 NC_011748.1 methylates the MCP; chemotaxis methyltransferase CheR 2120422 cheR 7145698 cheR Escherichia coli 55989 chemotaxis methyltransferase CheR YP_002403117.1 2119562 R 585055 CDS YP_002403118.1 218695451 7145699 complement(2120441..2122042) 1 NC_011748.1 mediates taxis toward dipeptides; methyl-accepting protein IV 2122042 tap 7145699 tap Escherichia coli 55989 methyl-accepting protein IV YP_002403118.1 2120441 R 585055 CDS YP_002403119.1 218695452 7147750 complement(2122088..2123749) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90094243, 92165727, 6305515, 9315712; Product type r : regulator; methyl-accepting chemotaxis protein II 2123749 tar 7147750 tar Escherichia coli 55989 methyl-accepting chemotaxis protein II YP_002403119.1 2122088 R 585055 CDS YP_002403120.1 218695453 7145650 complement(2123894..2124397) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91126073, 91296802, 91317710, 2002011, 3510184; Product type r : regulator; purine-binding chemotaxis protein 2124397 cheW 7145650 cheW Escherichia coli 55989 purine-binding chemotaxis protein YP_002403120.1 2123894 R 585055 CDS YP_002403121.1 218695454 7145700 complement(2124418..2126382) 1 NC_011748.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA 2126382 cheA 7145700 cheA Escherichia coli 55989 chemotaxis protein CheA YP_002403121.1 2124418 R 585055 CDS YP_002403122.1 218695455 7145697 complement(2126387..2127313) 1 NC_011748.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB 2127313 motB 7145697 motB Escherichia coli 55989 flagellar motor protein MotB YP_002403122.1 2126387 R 585055 CDS YP_002403123.1 218695456 7146889 complement(2127310..2128197) 1 NC_011748.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA 2128197 motA 7146889 motA Escherichia coli 55989 flagellar motor protein MotA YP_002403123.1 2127310 R 585055 CDS YP_002403124.1 218695457 7146888 complement(2128324..2128902) 1 NC_011748.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC 2128902 flhC 7146888 flhC Escherichia coli 55989 transcriptional activator FlhC YP_002403124.1 2128324 R 585055 CDS YP_002403125.1 218695458 7146140 complement(2128905..2129264) 1 NC_011748.1 with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD 2129264 flhD 7146140 flhD Escherichia coli 55989 transcriptional activator FlhD YP_002403125.1 2128905 R 585055 CDS YP_002403126.1 218695459 7146141 2130034..2130462 1 NC_011748.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 2130462 yecG 7146141 yecG Escherichia coli 55989 universal stress protein UspC YP_002403126.1 2130034 D 585055 CDS YP_002403127.1 218695460 7148565 complement(2130469..2131893) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 92121128, 93302496, 8045430; Product type e : enzyme; trehalose-6-phosphate synthase 2131893 otsA 7148565 otsA Escherichia coli 55989 trehalose-6-phosphate synthase YP_002403127.1 2130469 R 585055 CDS YP_002403128.1 218695461 7147085 complement(2131868..2132668) 1 NC_011748.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase 2132668 otsB 7147085 otsB Escherichia coli 55989 trehalose-6-phosphate phosphatase YP_002403128.1 2131868 R 585055 CDS YP_002403129.1 218695462 7147086 complement(2132835..2133824) 1 NC_011748.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease 2133824 araH 7147086 araH Escherichia coli 55989 L-arabinose transporter permease YP_002403129.1 2132835 R 585055 CDS YP_002403130.1 218695463 7145520 complement(2133836..2135350) 1 NC_011748.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein 2135350 araG 7145520 araG Escherichia coli 55989 L-arabinose transporter ATP-binding protein YP_002403130.1 2133836 R 585055 CDS YP_002403131.1 218695464 7145519 complement(2135420..2136409) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89255061, 90375534, 2445996, 326784, 326785, 6885805, 7031057, 9298646; Product type t : transporter; L-arabinose transporter subunit ; periplasmic-binding component of ABC superfamily 2136409 araF 7145519 araF Escherichia coli 55989 L-arabinose transporter subunit ; periplasmic-binding component of ABC superfamily YP_002403131.1 2135420 R 585055 CDS YP_002403132.1 218695465 7145518 2137206..2137709 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; ferritin-like protein 2137709 yecI 7145518 yecI Escherichia coli 55989 ferritin-like protein YP_002403132.1 2137206 D 585055 CDS YP_002403133.1 218695466 7148567 complement(2137788..2138039) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2138039 yecJ 7148567 yecJ Escherichia coli 55989 hypothetical protein YP_002403133.1 2137788 R 585055 CDS YP_002403134.1 218695467 7146634 2138151..2138297 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2138297 7146634 EC55989_2080 Escherichia coli 55989 hypothetical protein YP_002403134.1 2138151 D 585055 CDS YP_002403135.1 218695468 7144680 2138503..2138826 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2138826 yecR 7144680 yecR Escherichia coli 55989 hypothetical protein YP_002403135.1 2138503 D 585055 CDS YP_002403136.1 218695469 7148573 2138998..2139495 1 NC_011748.1 cytoplasmic iron storage protein; ferritin 2139495 ftn 7148573 ftn Escherichia coli 55989 ferritin YP_002403136.1 2138998 D 585055 CDS YP_002403137.1 218695470 7146209 complement(2139533..2139772) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2139772 yecH 7146209 yecH Escherichia coli 55989 hypothetical protein YP_002403137.1 2139533 R 585055 CDS YP_002403138.1 218695471 7148566 2139962..2141173 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89008121, 2022620; Product type t : transporter; tyrosine transporter 2141173 tyrP 7148566 tyrP Escherichia coli 55989 tyrosine transporter YP_002403138.1 2139962 D 585055 CDS YP_002403139.1 218695472 7147883 complement(2141235..2141900) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2141900 yecA 7147883 yecA Escherichia coli 55989 hypothetical protein YP_002403139.1 2141235 R 585055 CDS YP_002403140.1 218695473 7148560 complement(2142257..2143258) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Integrase 2143258 int 7148560 int Escherichia coli 55989 Integrase YP_002403140.1 2142257 R 585055 CDS YP_002403141.1 218695474 7146603 complement(2143264..2143611) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2143611 7146603 EC55989_2087 Escherichia coli 55989 hypothetical protein YP_002403141.1 2143264 R 585055 CDS YP_002403142.1 218695475 7144681 complement(2143641..2144291) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2144291 7144681 EC55989_2088 Escherichia coli 55989 hypothetical protein YP_002403142.1 2143641 R 585055 CDS YP_002403143.1 218695476 7144682 complement(2144307..2144711) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; regulator 2144711 7144682 EC55989_2089 Escherichia coli 55989 regulator YP_002403143.1 2144307 R 585055 CDS YP_002403144.1 218695477 7144683 2144787..2144993 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2144993 7144683 EC55989_2090 Escherichia coli 55989 hypothetical protein YP_002403144.1 2144787 D 585055 CDS YP_002403145.1 218695478 7144684 2145010..2145213 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage regulator DNA-binding protein) 2145213 7144684 EC55989_2091 Escherichia coli 55989 phage regulator DNA-binding protein) YP_002403145.1 2145010 D 585055 CDS YP_002403146.1 218695479 7144685 2145425..2145586 1 NC_011748.1 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; hypothetical protein 2145586 7144685 EC55989_2092 Escherichia coli 55989 hypothetical protein YP_002403146.1 2145425 D 585055 CDS YP_002403147.1 218695480 7144686 2145537..2145875 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2145875 7144686 EC55989_2093 Escherichia coli 55989 hypothetical protein YP_002403147.1 2145537 D 585055 CDS YP_002403148.1 218695481 7144687 2145884..2146129 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2146129 7144687 EC55989_2094 Escherichia coli 55989 hypothetical protein YP_002403148.1 2145884 D 585055 CDS YP_002403149.1 218695482 7144688 2146275..2146529 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2146529 7144688 EC55989_2095 Escherichia coli 55989 hypothetical protein YP_002403149.1 2146275 D 585055 CDS YP_002403150.1 218695483 7144689 2146469..2146771 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2146771 7144689 EC55989_2096 Escherichia coli 55989 hypothetical protein YP_002403150.1 2146469 D 585055 CDS YP_002403151.1 218695484 7144690 2146913..2147278 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2147278 7144690 EC55989_2097 Escherichia coli 55989 hypothetical protein YP_002403151.1 2146913 D 585055 CDS YP_002403152.1 218695485 7144691 2147285..2150107 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage replication protein 2150107 7144691 EC55989_2098 Escherichia coli 55989 phage replication protein YP_002403152.1 2147285 D 585055 CDS YP_002403153.1 218695486 7144692 2150184..2151143 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Plasmid segregation protein parM (Protein stbA) (ParA locus 36 kDa protein) 2151143 parM 7144692 parM Escherichia coli 55989 Plasmid segregation protein parM (Protein stbA) (ParA locus 36 kDa protein) YP_002403153.1 2150184 D 585055 CDS YP_002403154.1 218695487 7147117 2151148..2151462 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; stability/partitioning protein phage encoded ( plasmid partition protein) (modular protein) 2151462 7147117 EC55989_2100 Escherichia coli 55989 stability/partitioning protein phage encoded ( plasmid partition protein) (modular protein) YP_002403154.1 2151148 D 585055 CDS YP_002403155.1 218695488 7144693 2151482..2151913 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2151913 7144693 EC55989_2101 Escherichia coli 55989 hypothetical protein YP_002403155.1 2151482 D 585055 CDS YP_002403156.1 218695489 7144694 2151894..2152178 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2152178 7144694 EC55989_2102 Escherichia coli 55989 hypothetical protein YP_002403156.1 2151894 D 585055 CDS YP_002403157.1 218695490 7144695 complement(2152201..2152587) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2152587 7144695 EC55989_2103 Escherichia coli 55989 hypothetical protein YP_002403157.1 2152201 R 585055 CDS YP_002403158.1 218695491 7144696 complement(2152690..2153736) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; portal capsid protein Q (GpQ) 2153736 Q 7144696 Q Escherichia coli 55989 portal capsid protein Q (GpQ) YP_002403158.1 2152690 R 585055 CDS YP_002403159.1 218695492 7147327 complement(2153736..2155487) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Terminase, ATPase subunit (GpP) 2155487 P 7147327 P Escherichia coli 55989 Terminase, ATPase subunit (GpP) YP_002403159.1 2153736 R 585055 CDS YP_002403160.1 218695493 7147090 2155609..2156478 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Capsid scaffolding protein O 2156478 O 7147090 O Escherichia coli 55989 Capsid scaffolding protein O YP_002403160.1 2155609 D 585055 CDS YP_002403161.1 218695494 7147061 2156502..2157554 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major capsid protein precursor (GpN) 2157554 N 7147061 N Escherichia coli 55989 Major capsid protein precursor (GpN) YP_002403161.1 2156502 D 585055 CDS YP_002403162.1 218695495 7146939 2157600..2158400 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Phage terminase, endonuclease small subunit M 2158400 M 7146939 M Escherichia coli 55989 Phage terminase, endonuclease small subunit M YP_002403162.1 2157600 D 585055 CDS YP_002403163.1 218695496 7146762 2158432..2158998 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Head completion/stabilization protein L 2158998 L 7146762 L Escherichia coli 55989 Head completion/stabilization protein L YP_002403163.1 2158432 D 585055 CDS YP_002403164.1 218695497 7146674 2158982..2159524 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2159524 7146674 EC55989_2111 Escherichia coli 55989 hypothetical protein YP_002403164.1 2158982 D 585055 CDS YP_002403165.1 218695498 7144697 2158998..2159198 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail protein X (GpX) 2159198 X 7144697 X Escherichia coli 55989 Tail protein X (GpX) YP_002403165.1 2158998 D 585055 CDS YP_002403166.1 218695499 7147981 2159521..2159913 1 NC_011748.1 hypothetical protein 2159913 7147981 EC55989_2112 Escherichia coli 55989 hypothetical protein YP_002403166.1 2159521 D 585055 CDS YP_002403167.1 218695500 7144698 2159766..2160317 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2160317 7144698 EC55989_2113 Escherichia coli 55989 hypothetical protein YP_002403167.1 2159766 D 585055 CDS YP_002403168.1 218695501 7144699 2160456..2162336 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2162336 7144699 EC55989_2114 Escherichia coli 55989 hypothetical protein YP_002403168.1 2160456 D 585055 CDS YP_002403169.1 218695502 7144700 2162360..2162827 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Phage tail completion protein R 2162827 R 7144700 R Escherichia coli 55989 Phage tail completion protein R YP_002403169.1 2162360 D 585055 CDS YP_002403170.1 218695503 7147334 2162811..2163455 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage tail protein S 2163455 S 7147334 S Escherichia coli 55989 phage tail protein S YP_002403170.1 2162811 D 585055 CDS YP_002403171.1 218695504 7147599 2163452..2164033 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; baseplate assembly protein V 2164033 V 7147599 V Escherichia coli 55989 baseplate assembly protein V YP_002403171.1 2163452 D 585055 CDS YP_002403172.1 218695505 7147944 2164030..2164380 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein W 2164380 W 7147944 W Escherichia coli 55989 Baseplate assembly protein W YP_002403172.1 2164030 D 585055 CDS YP_002403173.1 218695506 7147955 2164384..2165280 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein J 2165280 J 7147955 J Escherichia coli 55989 Baseplate assembly protein J YP_002403173.1 2164384 D 585055 CDS YP_002403174.1 218695507 7146644 2165273..2165881 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail protein I 2165881 I 7146644 I Escherichia coli 55989 Tail protein I YP_002403174.1 2165273 D 585055 CDS YP_002403175.1 218695508 7144701 2167893..2168471 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; tail fiber chaperone; Qin prophage 2168471 tfaQ 7144701 tfaQ Escherichia coli 55989 tail fiber chaperone; Qin prophage YP_002403175.1 2167893 D 585055 CDS YP_002403176.1 218695509 7147780 complement(2168515..2169120) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; serine acetlyltransferase from phage 2169120 7147780 EC55989_2123 Escherichia coli 55989 serine acetlyltransferase from phage YP_002403176.1 2168515 R 585055 CDS YP_002403177.1 218695510 7144702 complement(2169244..2169738) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber protein 2169738 7144702 EC55989_2124 Escherichia coli 55989 tail fiber protein YP_002403177.1 2169244 R 585055 CDS YP_002403178.1 218695511 7144703 complement(2169745..2172561) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail protein (modular protein) 2172561 7144703 EC55989_2125 Escherichia coli 55989 tail protein (modular protein) YP_002403178.1 2169745 R 585055 CDS YP_002403179.1 218695512 7144704 complement(2172539..2172775) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage tail protein E' 2172775 7144704 EC55989_2126 Escherichia coli 55989 phage tail protein E' YP_002403179.1 2172539 R 585055 CDS YP_002403180.1 218695513 7144705 complement(2172703..2173077) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage tail protein E 2173077 7144705 EC55989_2127 Escherichia coli 55989 phage tail protein E YP_002403180.1 2172703 R 585055 CDS YP_002403181.1 218695514 7144706 complement(2173133..2173645) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail tube protein FII 2173645 fII 7144706 fII Escherichia coli 55989 Major tail tube protein FII YP_002403181.1 2173133 R 585055 CDS YP_002403182.1 218695515 7146110 complement(2173645..2174829) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail sheath protein FI 2174829 fI 7146110 fI Escherichia coli 55989 Major tail sheath protein FI YP_002403182.1 2173645 R 585055 CDS YP_002403183.1 218695516 7146106 2174855..2176096 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Gene late control D protein 2176096 D 7146106 D Escherichia coli 55989 Gene late control D protein YP_002403183.1 2174855 D 585055 CDS YP_002403184.1 218695517 7145840 complement(2176920..2177315) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2177315 7145840 EC55989_2131 Escherichia coli 55989 hypothetical protein YP_002403184.1 2176920 R 585055 CDS YP_002403185.1 218695518 7145392 complement(2178194..2178742) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 381294, 7007311, 94253011, 1323047, 3003065, 8917447; Product type e : enzyme; phosphatidylglycerophosphate synthetase 2178742 pgsA 7145392 pgsA Escherichia coli 55989 phosphatidylglycerophosphate synthetase YP_002403185.1 2178194 R 585055 CDS YP_002403186.1 218695519 7147156 complement(2178799..2180631) 1 NC_011748.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C 2180631 uvrC 7147156 uvrC Escherichia coli 55989 excinuclease ABC subunit C YP_002403186.1 2178799 R 585055 CDS YP_002403187.1 218695520 7147935 complement(2180628..2181284) 1 NC_011748.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator 2181284 uvrY 7147935 uvrY Escherichia coli 55989 response regulator YP_002403187.1 2180628 R 585055 CDS YP_002403188.1 218695521 7147937 2181580..2181756 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 2181756 7147937 EC55989_2135 Escherichia coli 55989 hypothetical protein YP_002403188.1 2181580 D 585055 CDS YP_002403189.1 218695522 7144708 2181743..2181967 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3515318, 7567469; hypothetical protein 2181967 yecF 7144708 yecF Escherichia coli 55989 hypothetical protein YP_002403189.1 2181743 D 585055 CDS YP_002403190.1 218695523 7148564 complement(2182035..2182757) 1 NC_011748.1 regulates genes involved in cell division; DNA-binding transcriptional activator SdiA 2182757 sdiA 7148564 sdiA Escherichia coli 55989 DNA-binding transcriptional activator SdiA YP_002403190.1 2182035 R 585055 CDS YP_002403191.1 218695524 7147619 complement(2182987..2183739) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; amino-acid ABC transporter ATP-binding protein YecC 2183739 yecC 7147619 yecC Escherichia coli 55989 amino-acid ABC transporter ATP-binding protein YecC YP_002403191.1 2182987 R 585055 CDS YP_002403192.1 218695525 7148561 complement(2183736..2184404) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: permease component of ABC superfamily transporter 2184404 yecS 7148561 yecS Escherichia coli 55989 transporter subunit: permease component of ABC superfamily transporter YP_002403192.1 2183736 R 585055 CDS YP_002403193.1 218695526 7148574 complement(2184419..2185405) 1 NC_011748.1 catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase 2185405 yedO 7148574 yedO Escherichia coli 55989 D-cysteine desulfhydrase YP_002403193.1 2184419 R 585055 CDS YP_002403194.1 218695527 7148583 complement(2185510..2186310) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125225, 8450713, 8774726, 9298646, 9740056; Product type t : transporter; cystine transporter subunit 2186310 fliY 7148583 fliY Escherichia coli 55989 cystine transporter subunit YP_002403194.1 2185510 R 585055 CDS YP_002403195.1 218695528 7146160 complement(2186398..2186949) 1 NC_011748.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ 2186949 fliZ 7146160 fliZ Escherichia coli 55989 flagella biosynthesis protein FliZ YP_002403195.1 2186398 R 585055 CDS YP_002403196.1 218695529 7146161 complement(2186995..2187714) 1 NC_011748.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor 2187714 fliA 7146161 fliA Escherichia coli 55989 flagellar biosynthesis sigma factor YP_002403196.1 2186995 R 585055 CDS YP_002403197.1 218695530 7146143 complement(2187878..2188927) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type ps : structure; Flagellin 2188927 7146143 EC55989_2144 Escherichia coli 55989 Flagellin YP_002403197.1 2187878 R 585055 CDS YP_002403198.1 218695531 7144709 2189175..2190590 1 NC_011748.1 involved in flagellin assembly; flagellar capping protein 2190590 fliD 7144709 fliD Escherichia coli 55989 flagellar capping protein YP_002403198.1 2189175 D 585055 CDS YP_002403199.1 218695532 7144710 2190606..2191016 1 NC_011748.1 flagellin specific chaperone; flagellar protein FliS 2191016 fliS 7144710 fliS Escherichia coli 55989 flagellar protein FliS YP_002403199.1 2190606 D 585055 CDS YP_002403200.1 218695533 7146158 2191016..2191381 1 NC_011748.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 2191381 fliT 7146158 fliT Escherichia coli 55989 flagellar biosynthesis protein FliT YP_002403200.1 2191016 D 585055 CDS YP_002403201.1 218695534 7146159 2191459..2192946 1 NC_011748.1 converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 2192946 amyA 7146159 amyA Escherichia coli 55989 alpha-amylase YP_002403201.1 2191459 D 585055 CDS YP_002403202.1 218695535 7145500 complement(2192980..2193393) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2193393 yedD 7145500 yedD Escherichia coli 55989 hypothetical protein YP_002403202.1 2192980 R 585055 CDS YP_002403203.1 218695536 7148577 2193580..2194785 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2194785 yedE 7148577 yedE Escherichia coli 55989 inner membrane protein YP_002403203.1 2193580 D 585055 CDS YP_002403204.1 218695537 7148578 2194782..2195015 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2195015 yedF 7148578 yedF Escherichia coli 55989 hypothetical protein YP_002403204.1 2194782 D 585055 CDS YP_002403205.1 218695538 7148582 2195810..2196379 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase ORF A, IS609 family 2196379 7148582 EC55989_2153 Escherichia coli 55989 transposase ORF A, IS609 family YP_002403205.1 2195810 D 585055 CDS YP_002403206.1 218695539 7144711 complement(2196536..2197333) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12270809; Product type pr : regulator; DNA-binding transcriptional regulator; DLP12 prophage 2197333 ybcM 7144711 ybcM Escherichia coli 55989 DNA-binding transcriptional regulator; DLP12 prophage YP_002403206.1 2196536 R 585055 CDS YP_002403207.1 218695540 7148131 complement(2197343..2197894) 1 NC_011748.1 DLP12 prophage; similar to PEBP/RK1P protein family in eukaryotes that inhibits MEK phosphorylation by Raf-1; crystal structure suggests similar properties but exact function is unknown; kinase inhibitor 2197894 ybcL 7148131 ybcL Escherichia coli 55989 kinase inhibitor YP_002403207.1 2197343 R 585055 CDS YP_002403208.1 218695541 7148130 complement(2198063..2198575) 1 NC_011748.1 member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein 2198575 emrE 7148130 emrE Escherichia coli 55989 multidrug efflux protein YP_002403208.1 2198063 R 585055 CDS YP_002403209.1 218695542 7145993 complement(2198739..2199053) 1 NC_011748.1 forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE 2199053 fliE 7145993 fliE Escherichia coli 55989 flagellar hook-basal body protein FliE YP_002403209.1 2198739 R 585055 CDS YP_002403210.1 218695543 7146144 2199268..2200926 1 NC_011748.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 2200926 fliF 7146144 fliF Escherichia coli 55989 flagellar MS-ring protein YP_002403210.1 2199268 D 585055 CDS YP_002403211.1 218695544 7146145 2200919..2201914 1 NC_011748.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 2201914 fliG 7146145 fliG Escherichia coli 55989 flagellar motor switch protein G YP_002403211.1 2200919 D 585055 CDS YP_002403212.1 218695545 7146146 2201907..2202593 1 NC_011748.1 binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 2202593 fliH 7146146 fliH Escherichia coli 55989 flagellar assembly protein H YP_002403212.1 2201907 D 585055 CDS YP_002403213.1 218695546 7146147 2202593..2203966 1 NC_011748.1 involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 2203966 fliI 7146147 fliI Escherichia coli 55989 flagellum-specific ATP synthase YP_002403213.1 2202593 D 585055 CDS YP_002403214.1 218695547 7146148 2203985..2204428 1 NC_011748.1 rod/hook and filament chaperone; flagellar biosynthesis chaperone 2204428 fliJ 7146148 fliJ Escherichia coli 55989 flagellar biosynthesis chaperone YP_002403214.1 2203985 D 585055 CDS YP_002403215.1 218695548 7146149 2204425..2205552 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1482109, 8631687; Product type s : structure; flagellar hook-length control protein 2205552 fliK 7146149 fliK Escherichia coli 55989 flagellar hook-length control protein YP_002403215.1 2204425 D 585055 CDS YP_002403216.1 218695549 7146150 2205657..2206121 1 NC_011748.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 2206121 fliL 7146150 fliL Escherichia coli 55989 flagellar basal body-associated protein FliL YP_002403216.1 2205657 D 585055 CDS YP_002403217.1 218695550 7146151 2206126..2207130 1 NC_011748.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 2207130 fliM 7146151 fliM Escherichia coli 55989 flagellar motor switch protein FliM YP_002403217.1 2206126 D 585055 CDS YP_002403218.1 218695551 7146152 2207127..2207540 1 NC_011748.1 One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 2207540 fliN 7146152 fliN Escherichia coli 55989 flagellar motor switch protein FliN YP_002403218.1 2207127 D 585055 CDS YP_002403219.1 218695552 7146153 2207543..2207908 1 NC_011748.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 2207908 fliO 7146153 fliO Escherichia coli 55989 flagellar biosynthesis protein FliO YP_002403219.1 2207543 D 585055 CDS YP_002403220.1 218695553 7146154 2207908..2208645 1 NC_011748.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 2208645 fliP 7146154 fliP Escherichia coli 55989 flagellar biosynthesis protein FliP YP_002403220.1 2207908 D 585055 CDS YP_002403221.1 218695554 7146155 2208655..2208924 1 NC_011748.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 2208924 fliQ 7146155 fliQ Escherichia coli 55989 flagellar biosynthesis protein FliQ YP_002403221.1 2208655 D 585055 CDS YP_002403222.1 218695555 7146156 2208933..2209718 1 NC_011748.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2209718 fliR 7146156 fliR Escherichia coli 55989 flagellar biosynthesis protein FliR YP_002403222.1 2208933 D 585055 CDS YP_002403223.1 218695556 7146157 2210008..2210631 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14514676, 14766922, 20167175, 90130299, 91154130, 92048476, 9882673, 7534408; Product type r : regulator; DNA-binding transcriptional activator, co-regulator with RcsB 2210631 rcsA 7146157 rcsA Escherichia coli 55989 DNA-binding transcriptional activator, co-regulator with RcsB YP_002403223.1 2210008 D 585055 CDS YP_002403224.1 218695557 7147347 complement(2210675..2210863) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96324407, 7534408; hypothetical protein 2210863 dsrB 7147347 dsrB Escherichia coli 55989 hypothetical protein YP_002403224.1 2210675 R 585055 CDS YP_002403225.1 218695558 7145958 2211026..2211253 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2211253 yodD 7145958 yodD Escherichia coli 55989 hypothetical protein YP_002403225.1 2211026 D 585055 CDS YP_002403226.1 218695559 7145956 2211552..2212367 1 NC_011748.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 2212367 yedP 7145956 yedP Escherichia coli 55989 mannosyl-3-phosphoglycerate phosphatase YP_002403226.1 2211552 D 585055 CDS YP_002403227.1 218695560 7148586 complement(2213979..2214167) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2214167 7148586 EC55989_2177 Escherichia coli 55989 hypothetical protein YP_002403227.1 2213979 R 585055 CDS YP_002403228.1 218695561 7144712 complement(2214229..2214411) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2214411 yodC 7144712 yodC Escherichia coli 55989 hypothetical protein YP_002403228.1 2214229 R 585055 CDS YP_002403229.1 218695562 7149347 complement(2214490..2215407) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2215407 yedI 7149347 yedI Escherichia coli 55989 hypothetical protein YP_002403229.1 2214490 R 585055 CDS YP_002403230.1 218695563 7148580 2215580..2216500 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2216500 yedA 7148580 yedA Escherichia coli 55989 hypothetical protein YP_002403230.1 2215580 D 585055 CDS YP_002403231.1 218695564 7148576 complement(2216489..2216959) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330522, 92049708, 94049122, 10360178, 10612397, 10871403, 2527357; Product type e : enzyme; DNA mismatch endonuclease of very short patch repair 2216959 vsr 7148576 vsr Escherichia coli 55989 DNA mismatch endonuclease of very short patch repair YP_002403231.1 2216489 R 585055 CDS YP_002403232.1 218695565 7147953 complement(2216940..2218358) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90280700, 91285397, 93367813, 2198248, 2527357; Product type e : enzyme; DNA cytosine methylase 2218358 dcm 7147953 dcm Escherichia coli 55989 DNA cytosine methylase YP_002403232.1 2216940 R 585055 CDS YP_002403233.1 218695566 7145856 complement(2218425..2219120) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : enzyme; hypothetical protein 2219120 yedJ 7145856 yedJ Escherichia coli 55989 hypothetical protein YP_002403233.1 2218425 R 585055 CDS YP_002403234.1 218695567 7148581 complement(2219160..2219525) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2219525 yedR 7148581 yedR Escherichia coli 55989 inner membrane protein YP_002403234.1 2219160 R 585055 CDS YP_002403235.1 218695568 7146599 complement(2221472..2222623) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094, 6092059; Product type e : enzyme; IS30 transposase; KpLE2 phage-like element 2222623 insI 7146599 insI Escherichia coli 55989 IS30 transposase; KpLE2 phage-like element YP_002403235.1 2221472 R 585055 CDS YP_002403236.1 218695569 7147434 2222763..2223581 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase ORF B, IS600 2223581 7147434 EC55989_2189 Escherichia coli 55989 transposase ORF B, IS600 YP_002403236.1 2222763 D 585055 CDS YP_002403237.1 218695570 7144715 complement(2224087..2224590) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 2224590 insB 7144715 insB Escherichia coli 55989 IS1 transposase InsAB' YP_002403237.1 2224087 R 585055 CDS YP_002403238.1 218695571 7146588 complement(2224509..2224784) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 2224784 insA 7146588 insA Escherichia coli 55989 IS1 repressor protein InsA YP_002403238.1 2224509 R 585055 CDS YP_002403239.1 218695572 7146576 2224870..2225721 1 NC_011748.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2225721 hchA 7146576 hchA Escherichia coli 55989 chaperone protein HchA YP_002403239.1 2224870 D 585055 CDS YP_002403240.1 218695573 7146397 complement(2225819..2227177) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865; Product type rc : receptor; sensory kinase in two-component regulatory system with YedW 2227177 yedV 7146397 yedV Escherichia coli 55989 sensory kinase in two-component regulatory system with YedW YP_002403240.1 2225819 R 585055 CDS YP_002403241.1 218695574 7148588 complement(2227177..2227848) 1 NC_011748.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW 2227848 yedW 7148588 yedW Escherichia coli 55989 transcriptional regulatory protein YedW YP_002403241.1 2227177 R 585055 CDS YP_002403242.1 218695575 7148589 2227981..2228394 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2228394 yedX 7148589 yedX Escherichia coli 55989 hypothetical protein YP_002403242.1 2227981 D 585055 CDS YP_002403243.1 218695576 7148590 2228503..2229507 1 NC_011748.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY 2229507 yedY 7148590 yedY Escherichia coli 55989 sulfite oxidase subunit YedY YP_002403243.1 2228503 D 585055 CDS YP_002403244.1 218695577 7148591 2229508..2230143 1 NC_011748.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 2230143 yedZ 7148591 yedZ Escherichia coli 55989 sulfite oxidase subunit YedZ YP_002403244.1 2229508 D 585055 CDS YP_002403245.1 218695578 7148592 2230400..2231050 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12077457, 12480884, 12909634, 9579078; hypothetical protein 2231050 yodA 7148592 yodA Escherichia coli 55989 hypothetical protein YP_002403245.1 2230400 D 585055 CDS YP_002403246.1 218695579 7145391 2231903..2232700 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2232700 yeeI 7145391 yeeI Escherichia coli 55989 hypothetical protein YP_002403246.1 2231903 D 585055 CDS YP_002403247.1 218695580 7145331 2233038..2234300 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase 2234300 int 7145331 int Escherichia coli 55989 integrase YP_002403247.1 2233038 D 585055 CDS YP_002403248.1 218695581 7146604 complement(2234494..2235798) 1 NC_011748.1 catalyzes the conversion of chorismate to salicylate in the biosynthesis of the siderophore yersiniabactin; salicylate synthase Irp9 2235798 irp 7146604 irp Escherichia coli 55989 salicylate synthase Irp9 YP_002403248.1 2234494 R 585055 CDS YP_002403249.1 218695582 7146611 complement(2235826..2237229) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; yersiniabactin-iron transporter permease YbtX 2237229 irp 7146611 irp Escherichia coli 55989 yersiniabactin-iron transporter permease YbtX YP_002403249.1 2235826 R 585055 CDS YP_002403250.1 218695583 7146612 complement(2237099..2238928) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10231486, 11320115; Product type t : transporter; permease and ATP-binding protein of yersiniabactin-iron ABC transporter YbtQ 2238928 irp 7146612 irp Escherichia coli 55989 permease and ATP-binding protein of yersiniabactin-iron ABC transporter YbtQ YP_002403250.1 2237099 R 585055 CDS YP_002403251.1 218695584 7146613 complement(2238888..2240690) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10231486, 11320115; Product type t : transporter; permease and ATP-binding protein of yersiniabactin-iron ABC transporter YbtP 2240690 irp 7146613 irp Escherichia coli 55989 permease and ATP-binding protein of yersiniabactin-iron ABC transporter YbtP YP_002403251.1 2238888 R 585055 CDS YP_002403252.1 218695585 7146614 2240857..2241816 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8930916; Product type r : regulator; AraC family transcriptional regulator 2241816 ybtA 7146614 ybtA Escherichia coli 55989 AraC family transcriptional regulator YP_002403252.1 2240857 D 585055 CDS YP_002403253.1 218695586 7148239 2241989..2248114 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15719346, 15582399, 8366034, 11927258, 9709002; Product type e : enzyme; High-molecular-weight nonribosomal peptide/polyketide synthetase 2 (HMWP2) 2248114 irp 7148239 irp Escherichia coli 55989 High-molecular-weight nonribosomal peptide/polyketide synthetase 2 (HMWP2) YP_002403253.1 2241989 D 585055 CDS YP_002403254.1 218695587 7146615 2248202..2257693 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15719346, 15582399, 11927258; Product type e : enzyme; High-molecular-weight nonribosomal peptide/polyketide synthetase 1 (HMWP1) 2257693 irp 7146615 irp Escherichia coli 55989 High-molecular-weight nonribosomal peptide/polyketide synthetase 1 (HMWP1) YP_002403254.1 2248202 D 585055 CDS YP_002403255.1 218695588 7146616 2257630..2258790 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11927258; Product type e : enzyme; Thiazolinyl-S-HMWP1 reductase YbtU 2258790 irp 7146616 irp Escherichia coli 55989 Thiazolinyl-S-HMWP1 reductase YbtU YP_002403255.1 2257630 D 585055 CDS YP_002403256.1 218695589 7146617 2258787..2259590 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; thioesterase YbtT 2259590 irp 7146617 irp Escherichia coli 55989 thioesterase YbtT YP_002403256.1 2258787 D 585055 CDS YP_002403257.1 218695590 7146618 2259594..2261171 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9818149, 11927258, 9709002; Product type e : enzyme; salicyl-AMP ligase YbtE 2261171 irp 7146618 irp Escherichia coli 55989 salicyl-AMP ligase YbtE YP_002403257.1 2259594 D 585055 CDS YP_002403258.1 218695591 7146619 2261302..2263323 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7896707, 7984105; Product type rc : receptor; Yersiniabactin/pesticin outer membrane receptor (IRPC) 2263323 fyuA 7146619 fyuA Escherichia coli 55989 Yersiniabactin/pesticin outer membrane receptor (IRPC) YP_002403258.1 2261302 D 585055 CDS YP_002403259.1 218695592 7148601 complement(2266942..2268057) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2268057 7148601 EC55989_2217 Escherichia coli 55989 hypothetical protein YP_002403259.1 2266942 R 585055 CDS YP_002403260.1 218695593 7144716 2268309..2269625 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 5332864, 9524262; Product type t : transporter; shikimate transporter 2269625 shiA 7144716 shiA Escherichia coli 55989 shikimate transporter YP_002403260.1 2268309 D 585055 CDS YP_002403261.1 218695594 7147653 2269727..2271181 1 NC_011748.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2271181 amn 7147653 amn Escherichia coli 55989 AMP nucleosidase YP_002403261.1 2269727 D 585055 CDS YP_002403262.1 218695595 7145493 2271524..2272240 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2272240 yeeN 7145493 yeeN Escherichia coli 55989 hypothetical protein YP_002403262.1 2271524 D 585055 CDS YP_002403263.1 218695596 7145390 complement(2272868..2274508) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16042411; Product type pt : transporter; hypothetical protein 2274508 yeeO 7145390 yeeO Escherichia coli 55989 hypothetical protein YP_002403263.1 2272868 R 585055 CDS YP_002403264.1 218695597 7145332 complement(2274629..2275579) 1 NC_011748.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl 2275579 cbl 7145332 cbl Escherichia coli 55989 transcriptional regulator Cbl YP_002403264.1 2274629 R 585055 CDS YP_002403265.1 218695598 7145666 complement(2275681..2276598) 1 NC_011748.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator 2276598 nac 7145666 nac Escherichia coli 55989 nitrogen assimilation transcriptional regulator YP_002403265.1 2275681 R 585055 CDS YP_002403266.1 218695599 7145333 complement(2277056..2277988) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein 2277988 erfK 7145333 erfK Escherichia coli 55989 hypothetical protein YP_002403266.1 2277056 R 585055 CDS YP_002403267.1 218695600 7146022 complement(2278053..2279132) 1 NC_011748.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase 2279132 cobT 7146022 cobT Escherichia coli 55989 nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase YP_002403267.1 2278053 R 585055 CDS YP_002403268.1 218695601 7145737 complement(2279144..2279887) 1 NC_011748.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase 2279887 cobS 7145737 cobS Escherichia coli 55989 cobalamin synthase YP_002403268.1 2279144 R 585055 CDS YP_002403269.1 218695602 7145736 complement(2279884..2280429) 1 NC_011748.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase 2280429 cobU 7145736 cobU Escherichia coli 55989 adenosylcobinamide kinase YP_002403269.1 2279884 R 585055 CDS YP_002403270.1 218695603 7144717 complement(2280894..2281058) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2281058 7144717 EC55989_2229 Escherichia coli 55989 hypothetical protein YP_002403270.1 2280894 R 585055 CDS YP_002403271.1 218695604 7144718 2282184..2282300 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 2282300 7144718 EC55989_2231 Escherichia coli 55989 hypothetical protein YP_002403271.1 2282184 D 585055 CDS YP_002403272.1 218695605 7144719 2282496..2283710 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; carbohydrate kinase 2283710 7144719 EC55989_2232 Escherichia coli 55989 carbohydrate kinase YP_002403272.1 2282496 D 585055 CDS YP_002403273.1 218695606 7144720 2283724..2284482 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2284482 7144720 EC55989_2233 Escherichia coli 55989 hypothetical protein YP_002403273.1 2283724 D 585055 CDS YP_002403274.1 218695607 7144723 2285507..2286541 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; phosphotriesterase-related protein 2286541 7144723 EC55989_2236 Escherichia coli 55989 phosphotriesterase-related protein YP_002403274.1 2285507 D 585055 CDS YP_002403275.1 218695608 7146281 complement(2286685..2286909) 1 NC_011748.1 hypothetical protein 2286909 7146281 EC55989_2238 Escherichia coli 55989 hypothetical protein YP_002403275.1 2286685 R 585055 CDS YP_002403276.1 218695609 7144726 complement(2287193..2288572) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase, ISL3 family 2288572 7144726 EC55989_2240 Escherichia coli 55989 transposase, ISL3 family YP_002403276.1 2287193 R 585055 CDS YP_002403277.1 218695610 7144727 complement(2288856..2289353) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2289353 7144727 EC55989_2241 Escherichia coli 55989 hypothetical protein YP_002403277.1 2288856 R 585055 CDS YP_002403278.1 218695611 7144728 complement(2289254..2289661) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2289661 7144728 EC55989_2242 Escherichia coli 55989 hypothetical protein YP_002403278.1 2289254 R 585055 CDS YP_002403279.1 218695612 7144729 complement(2289915..2290520) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2290520 7144729 EC55989_2243 Escherichia coli 55989 hypothetical protein YP_002403279.1 2289915 R 585055 CDS YP_002403280.1 218695613 7144730 2291810..2292217 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; InterPro motifs Prophage CP4-57 regulatory protein (AlpA) 2292217 7144730 EC55989_2244 Escherichia coli 55989 InterPro motifs Prophage CP4-57 regulatory protein (AlpA) YP_002403280.1 2291810 D 585055 CDS YP_002403281.1 218695614 7144731 2292296..2292913 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2292913 7144731 EC55989_2245 Escherichia coli 55989 hypothetical protein YP_002403281.1 2292296 D 585055 CDS YP_002403282.1 218695615 7144732 2293341..2293601 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2293601 7144732 EC55989_2246 Escherichia coli 55989 hypothetical protein YP_002403282.1 2293341 D 585055 CDS YP_002403284.1 218695617 7144734 complement(2293872..2295407) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase ORF 1, IS66 family 2295407 7144734 EC55989_2248 Escherichia coli 55989 transposase ORF 1, IS66 family YP_002403284.1 2293872 R 585055 CDS YP_002403285.1 218695618 7144735 complement(2295457..2295804) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase ORF 2, IS66 family 2295804 7144735 EC55989_2249 Escherichia coli 55989 transposase ORF 2, IS66 family YP_002403285.1 2295457 R 585055 CDS YP_002403286.1 218695619 7144736 2297740..2298903 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2298903 7144736 EC55989_2250 Escherichia coli 55989 hypothetical protein YP_002403286.1 2297740 D 585055 CDS YP_002403287.1 218695620 7144739 2300076..2302472 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2302472 7144739 EC55989_2253 Escherichia coli 55989 hypothetical protein YP_002403287.1 2300076 D 585055 CDS YP_002403288.1 218695621 7144740 2302469..2303374 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2303374 7144740 EC55989_2254 Escherichia coli 55989 hypothetical protein YP_002403288.1 2302469 D 585055 CDS YP_002403289.1 218695622 7144741 2303371..2304441 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2304441 7144741 EC55989_2255 Escherichia coli 55989 hypothetical protein YP_002403289.1 2303371 D 585055 CDS YP_002403290.1 218695623 7144742 2304469..2305260 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2305260 7144742 EC55989_2256 Escherichia coli 55989 hypothetical protein YP_002403290.1 2304469 D 585055 CDS YP_002403291.1 218695624 7144743 2305276..2305686 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2305686 7144743 EC55989_2257 Escherichia coli 55989 hypothetical protein YP_002403291.1 2305276 D 585055 CDS YP_002403292.1 218695625 7144744 2305907..2306728 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2306728 7144744 EC55989_2258 Escherichia coli 55989 hypothetical protein YP_002403292.1 2305907 D 585055 CDS YP_002403293.1 218695626 7144745 2306810..2307289 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7519596; Product type h : extrachromosomal origin; antirestriction protein of plasmid origin 2307289 7144745 EC55989_2259 Escherichia coli 55989 antirestriction protein of plasmid origin YP_002403293.1 2306810 D 585055 CDS YP_002403294.1 218695627 7144746 2307335..2307781 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : factor; DNA repair protein; CP4-44 prophage 2307781 yeeS 7144746 yeeS Escherichia coli 55989 DNA repair protein; CP4-44 prophage YP_002403294.1 2307335 D 585055 CDS YP_002403295.1 218695628 7148604 2307844..2308065 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; CP4-44 prophage 2308065 yeeT 7148604 yeeT Escherichia coli 55989 CP4-44 prophage YP_002403295.1 2307844 D 585055 CDS YP_002403296.1 218695629 7148608 2308139..2308507 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; antitoxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 2308507 yeeU 7148608 yeeU Escherichia coli 55989 antitoxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage YP_002403296.1 2308139 D 585055 CDS YP_002403297.1 218695630 7148616 2308966..2309160 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; CP4-44 prophage 2309160 yeeW 7148616 yeeW Escherichia coli 55989 CP4-44 prophage YP_002403297.1 2308966 D 585055 CDS YP_002403298.1 218695631 7148619 2309601..2309957 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2309957 yoeF 7148619 yoeF Escherichia coli 55989 hypothetical protein YP_002403298.1 2309601 D 585055 CDS YP_002403299.1 218695632 7149350 complement(2310058..2310453) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2310453 yeeX 7149350 yeeX Escherichia coli 55989 hypothetical protein YP_002403299.1 2310058 R 585055 CDS YP_002403300.1 218695633 7148623 complement(2310559..2311617) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2311617 yeeA 7148623 yeeA Escherichia coli 55989 inner membrane protein YP_002403300.1 2310559 R 585055 CDS YP_002403301.1 218695634 7148593 complement(2311815..2312288) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11850398, 9442027, 8709849; Product type r : regulator; DNA gyrase inhibitor 2312288 sbmC 7148593 sbmC Escherichia coli 55989 DNA gyrase inhibitor YP_002403301.1 2311815 R 585055 CDS YP_002403302.1 218695635 7147610 complement(2312407..2313573) 1 NC_011748.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 2313573 dacD 7147610 dacD Escherichia coli 55989 D-alanyl-D-alanine carboxypeptidase YP_002403302.1 2312407 R 585055 CDS YP_002403303.1 218695636 7145844 2313782..2315209 1 NC_011748.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2315209 sbcB 7145844 sbcB Escherichia coli 55989 exonuclease I YP_002403303.1 2313782 D 585055 CDS YP_002403304.1 218695637 7147606 complement(2315252..2315479) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2315479 yeeD 7147606 yeeD Escherichia coli 55989 hypothetical protein YP_002403304.1 2315252 R 585055 CDS YP_002403305.1 218695638 7148594 complement(2315493..2316551) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2316551 yeeE 7148594 yeeE Escherichia coli 55989 inner membrane protein YP_002403305.1 2315493 R 585055 CDS YP_002403306.1 218695639 7148595 complement(2316730..2318088) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; amino-acid/amine transporter 2318088 yeeF 7148595 yeeF Escherichia coli 55989 amino-acid/amine transporter YP_002403306.1 2316730 R 585055 CDS YP_002403307.1 218695640 7148596 complement(2318355..2319284) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 2319284 yeeY 7148596 yeeY Escherichia coli 55989 DNA-binding transcriptional regulator YP_002403307.1 2318355 R 585055 CDS YP_002403308.1 218695641 7148624 complement(2319330..2320154) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; epimerase, with NAD(P)-binding Rossmann-fold domain 2320154 yeeZ 7148624 yeeZ Escherichia coli 55989 epimerase, with NAD(P)-binding Rossmann-fold domain YP_002403308.1 2319330 R 585055 CDS YP_002403309.1 218695642 7148625 complement(2320237..2320491) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type f : factor; toxin of the YoeB-YefM toxin-antitoxin system 2320491 yoeB 7148625 yoeB Escherichia coli 55989 toxin of the YoeB-YefM toxin-antitoxin system YP_002403309.1 2320237 R 585055 CDS YP_002403310.1 218695643 7149349 complement(2320488..2320739) 1 NC_011748.1 Antitoxin that counteracts the effect of the YoeB toxin; antitoxin YefM 2320739 yefM 7149349 yefM Escherichia coli 55989 antitoxin YefM YP_002403310.1 2320488 R 585055 CDS YP_002403312.1 218695645 7145305 2321219..2322118 1 NC_011748.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2322118 hisG 7145305 hisG Escherichia coli 55989 ATP phosphoribosyltransferase YP_002403312.1 2321219 D 585055 CDS YP_002403313.1 218695646 7146435 2322124..2323428 1 NC_011748.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2323428 hisD 7146435 hisD Escherichia coli 55989 histidinol dehydrogenase YP_002403313.1 2322124 D 585055 CDS YP_002403314.1 218695647 7146433 2323425..2324495 1 NC_011748.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2324495 hisC 7146433 hisC Escherichia coli 55989 histidinol-phosphate aminotransferase YP_002403314.1 2323425 D 585055 CDS YP_002403315.1 218695648 7146432 2324495..2325562 1 NC_011748.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2325562 hisB 7146432 hisB Escherichia coli 55989 imidazole glycerol-phosphate dehydratase/histidinol phosphatase YP_002403315.1 2324495 D 585055 CDS YP_002403316.1 218695649 7146431 2325562..2326152 1 NC_011748.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2326152 hisH 7146431 hisH Escherichia coli 55989 imidazole glycerol phosphate synthase subunit HisH YP_002403316.1 2325562 D 585055 CDS YP_002403317.1 218695650 7146436 2326152..2326889 1 NC_011748.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2326889 hisA 7146436 hisA Escherichia coli 55989 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase YP_002403317.1 2326152 D 585055 CDS YP_002403318.1 218695651 7146430 2326871..2327647 1 NC_011748.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2327647 hisF 7146430 hisF Escherichia coli 55989 imidazole glycerol phosphate synthase subunit HisF YP_002403318.1 2326871 D 585055 CDS YP_002403319.1 218695652 7146434 2327641..2328252 1 NC_011748.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 2328252 hisI 7146434 hisI Escherichia coli 55989 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase YP_002403319.1 2327641 D 585055 CDS YP_002403320.1 218695653 7146437 complement(2328350..2329330) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98241528; Product type r : regulator; regulator of length of O-antigen component of lipopolysaccharide chains 2329330 cld 7146437 cld Escherichia coli 55989 regulator of length of O-antigen component of lipopolysaccharide chains YP_002403320.1 2328350 R 585055 CDS YP_002403321.1 218695654 7145720 complement(2329474..2330640) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150218, 96326333; Product type e : enzyme; UDP-glucose 6-dehydrogenase 2330640 ugd 7145720 ugd Escherichia coli 55989 UDP-glucose 6-dehydrogenase YP_002403321.1 2329474 R 585055 CDS YP_002403322.1 218695655 7147899 complement(2330888..2332294) 1 NC_011748.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase 2332294 gnd 7147899 gnd Escherichia coli 55989 6-phosphogluconate dehydrogenase YP_002403322.1 2330888 R 585055 CDS YP_002403323.1 218695656 7146346 complement(2332415..2333233) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; glycosyl transferase family protein 2333233 7146346 EC55989_2289 Escherichia coli 55989 glycosyl transferase family protein YP_002403323.1 2332415 R 585055 CDS YP_002403324.1 218695657 7144747 complement(2333246..2334541) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11404020; Product type pe : enzyme; Wzx 2334541 7144747 EC55989_2290 Escherichia coli 55989 Wzx YP_002403324.1 2333246 R 585055 CDS YP_002403325.1 218695658 7144748 complement(2334523..2335746) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11404020; Product type pe : enzyme; WbwB 2335746 7144748 EC55989_2291 Escherichia coli 55989 WbwB YP_002403325.1 2334523 R 585055 CDS YP_002403326.1 218695659 7144749 complement(2336861..2337811) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11404020; hypothetical protein 2337811 7144749 EC55989_2292 Escherichia coli 55989 hypothetical protein YP_002403326.1 2336861 R 585055 CDS YP_002403327.1 218695660 7144750 complement(2337896..2339059) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11404020; Product type pe : enzyme; NnaA 2339059 7144750 EC55989_2293 Escherichia coli 55989 NnaA YP_002403327.1 2337896 R 585055 CDS YP_002403328.1 218695661 7144751 complement(2339056..2340321) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11404020; Product type pe : enzyme; NnaC 2340321 7144751 EC55989_2294 Escherichia coli 55989 NnaC YP_002403328.1 2339056 R 585055 CDS YP_002403329.1 218695662 7144752 complement(2340327..2341367) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11404020; Product type pe : enzyme; NnaB 2341367 7144752 EC55989_2295 Escherichia coli 55989 NnaB YP_002403329.1 2340327 R 585055 CDS YP_002403330.1 218695663 7144753 complement(2341372..2341992) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11404020; Product type pe : enzyme; WckD 2341992 7144753 EC55989_2296 Escherichia coli 55989 WckD YP_002403330.1 2341372 R 585055 CDS YP_002403331.1 218695664 7144754 complement(2342353..2343246) 1 NC_011748.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 2343246 galF 7144754 galF Escherichia coli 55989 UTP-glucose-1-phosphate uridylyltransferase YP_002403331.1 2342353 R 585055 CDS YP_002403332.1 218695665 7146248 complement(2343489..2344484) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976290; Product type e : enzyme; UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase) 2344484 gne 7146248 gne Escherichia coli 55989 UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase) YP_002403332.1 2343489 R 585055 CDS YP_002403333.1 218695666 7146347 complement(2344642..2346036) 1 NC_011748.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; colanic acid biosynthesis protein 2346036 wcaM 7146347 wcaM Escherichia coli 55989 colanic acid biosynthesis protein YP_002403333.1 2344642 R 585055 CDS YP_002403334.1 218695667 7147972 complement(2346047..2347267) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : enzyme; glycosyl transferase family protein 2347267 wcaL 7147972 wcaL Escherichia coli 55989 glycosyl transferase family protein YP_002403334.1 2346047 R 585055 CDS YP_002403335.1 218695668 7147971 complement(2347264..2348544) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333, 8759852, 11004393; Product type pe : enzyme; pyruvyl transferase 2348544 wcaK 7147971 wcaK Escherichia coli 55989 pyruvyl transferase YP_002403335.1 2347264 R 585055 CDS YP_002403336.1 218695669 7147970 complement(2348829..2350307) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 8759852; Product type pt : transporter; colanic acid exporter 2350307 wzxC 7147970 wzxC Escherichia coli 55989 colanic acid exporter YP_002403336.1 2348829 R 585055 CDS YP_002403337.1 218695670 7147977 complement(2350309..2351703) 1 NC_011748.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; UDP-glucose lipid carrier transferase 2351703 wcaJ 7147977 wcaJ Escherichia coli 55989 UDP-glucose lipid carrier transferase YP_002403337.1 2350309 R 585055 CDS YP_002403338.1 218695671 7147969 complement(2351758..2353128) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106949, 96326333, 7815923, 8759852; Product type e : enzyme; phosphomannomutase 2353128 cpsG 7147969 cpsG Escherichia coli 55989 phosphomannomutase YP_002403338.1 2351758 R 585055 CDS YP_002403339.1 218695672 7145747 complement(2353497..2354933) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 85006781, 92048476, 93122523, 96326333, 7815923, 8759852; Product type e : enzyme; mannose-1-phosphate guanylyltransferase 2354933 cpsB 7145747 cpsB Escherichia coli 55989 mannose-1-phosphate guanylyltransferase YP_002403339.1 2353497 R 585055 CDS YP_002403340.1 218695673 7145746 complement(2354936..2356159) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15670885, 96326333; Product type pe : enzyme; glycosyl transferase family protein 2356159 wcaI 7145746 wcaI Escherichia coli 55989 glycosyl transferase family protein YP_002403340.1 2354936 R 585055 CDS YP_002403341.1 218695674 7147968 complement(2356156..2356635) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 10913267, 7592609, 7815923, 8759852; Product type e : enzyme; GDP-mannose mannosyl hydrolase 2356635 nudD 7147968 nudD Escherichia coli 55989 GDP-mannose mannosyl hydrolase YP_002403341.1 2356156 R 585055 CDS YP_002403342.1 218695675 7147038 complement(2356638..2357603) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 98132401, 9862812, 7815923, 8759852, 9473059; Product type e : enzyme; bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase 2357603 fcl 7147038 fcl Escherichia coli 55989 bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase YP_002403342.1 2356638 R 585055 CDS YP_002403343.1 218695676 7146065 complement(2357606..2358727) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20139699, 97400210, 10673432, 7815923, 8759852, 9257704, 14299611; Product type e : enzyme; GDP-D-mannose dehydratase 2358727 gmd 7146065 gmd Escherichia coli 55989 GDP-D-mannose dehydratase YP_002403343.1 2357606 R 585055 CDS YP_002403344.1 218695677 7146342 complement(2358754..2359302) 1 NC_011748.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); colanic acid biosynthesis acetyltransferase WcaF 2359302 wcaF 7146342 wcaF Escherichia coli 55989 colanic acid biosynthesis acetyltransferase WcaF YP_002403344.1 2358754 R 585055 CDS YP_002403345.1 218695678 7147967 complement(2359318..2360064) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11371548, 96326333, 8759852; Product type pe : enzyme; glycosyl transferase family protein 2360064 wcaE 7147967 wcaE Escherichia coli 55989 glycosyl transferase family protein YP_002403345.1 2359318 R 585055 CDS YP_002403346.1 218695679 7147966 complement(2360075..2361292) 1 NC_011748.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; colanic acid biosynthesis protein 2361292 wcaD 7147966 wcaD Escherichia coli 55989 colanic acid biosynthesis protein YP_002403346.1 2360075 R 585055 CDS YP_002403347.1 218695680 7147965 complement(2361267..2362484) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : enzyme; glycosyl transferase family protein 2362484 wcaC 7147965 wcaC Escherichia coli 55989 glycosyl transferase family protein YP_002403347.1 2361267 R 585055 CDS YP_002403348.1 218695681 7147964 complement(2362481..2362969) 1 NC_011748.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; colanic acid biosynthesis acetyltransferase WcaB 2362969 wcaB 7147964 wcaB Escherichia coli 55989 colanic acid biosynthesis acetyltransferase WcaB YP_002403348.1 2362481 R 585055 CDS YP_002403349.1 218695682 7147963 complement(2362972..2363811) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : enzyme; glycosyl transferase family protein 2363811 wcaA 7147963 wcaA Escherichia coli 55989 glycosyl transferase family protein YP_002403349.1 2362972 R 585055 CDS YP_002403350.1 218695683 7147962 complement(2363989..2366151) 1 NC_011748.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase 2366151 wzc 7147962 wzc Escherichia coli 55989 tyrosine kinase YP_002403350.1 2363989 R 585055 CDS YP_002403351.1 218695684 7147976 complement(2366154..2366597) 1 NC_011748.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase 2366597 wzb 7147976 wzb Escherichia coli 55989 tyrosine phosphatase YP_002403351.1 2366154 R 585055 CDS YP_002403352.1 218695685 7147975 complement(2366603..2367742) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15090537, 96326333, 8759852, 8763957; Product type lp : lipoprotein; lipoprotein required for capsular polysaccharide translocation through the outer membrane 2367742 wza 7147975 wza Escherichia coli 55989 lipoprotein required for capsular polysaccharide translocation through the outer membrane YP_002403352.1 2366603 R 585055 CDS YP_002403353.1 218695686 7147974 2368401..2369984 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; fused membrane protein ; membrane protein 2369984 yegH 7147974 yegH Escherichia coli 55989 fused membrane protein ; membrane protein YP_002403353.1 2368401 D 585055 CDS YP_002403354.1 218695687 7148629 complement(2370258..2372111) 1 NC_011748.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; assembly protein 2372111 asmA 7148629 asmA Escherichia coli 55989 assembly protein YP_002403354.1 2370258 R 585055 CDS YP_002403355.1 218695688 7145566 complement(2372133..2372714) 1 NC_011748.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase 2372714 dcd 7145566 dcd Escherichia coli 55989 deoxycytidine triphosphate deaminase YP_002403355.1 2372133 R 585055 CDS YP_002403356.1 218695689 7145855 complement(2372806..2373447) 1 NC_011748.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase 2373447 udk 7145855 udk Escherichia coli 55989 uridine kinase YP_002403356.1 2372806 R 585055 CDS YP_002403357.1 218695690 7147897 2373765..2377082 1 NC_011748.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction; sensor protein 2377082 yegE 7147897 yegE Escherichia coli 55989 sensor protein YP_002403357.1 2373765 D 585055 CDS YP_002403358.1 218695691 7148628 complement(2377121..2377978) 1 NC_011748.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyladenine DNA glycosylase 2377978 alkA 7148628 alkA Escherichia coli 55989 3-methyladenine DNA glycosylase YP_002403358.1 2377121 R 585055 CDS YP_002403359.1 218695692 7145481 2378112..2379464 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 6094528, 7940673, 7984428; Product type pf : factor; chaperone 2379464 yegD 7145481 yegD Escherichia coli 55989 chaperone YP_002403359.1 2378112 D 585055 CDS YP_002403360.1 218695693 7148627 complement(2379476..2381425) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2381425 yegI 7148627 yegI Escherichia coli 55989 hypothetical protein YP_002403360.1 2379476 R 585055 CDS YP_002403361.1 218695694 7148630 complement(2381413..2382174) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2382174 yegK 7148630 yegK Escherichia coli 55989 hypothetical protein YP_002403361.1 2381413 R 585055 CDS YP_002403362.1 218695695 7148631 complement(2382171..2382830) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2382830 yegL 7148631 yegL Escherichia coli 55989 hypothetical protein YP_002403362.1 2382171 R 585055 CDS YP_002403363.1 218695696 7145307 2384046..2385293 1 NC_011748.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2385293 mdtA 7145307 mdtA Escherichia coli 55989 multidrug efflux system subunit MdtA YP_002403363.1 2384046 D 585055 CDS YP_002403364.1 218695697 7146802 2385293..2388415 1 NC_011748.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 2388415 mdtB 7146802 mdtB Escherichia coli 55989 multidrug efflux system subunit MdtB YP_002403364.1 2385293 D 585055 CDS YP_002403365.1 218695698 7146803 2388416..2391493 1 NC_011748.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2391493 mdtC 7146803 mdtC Escherichia coli 55989 multidrug efflux system subunit MdtC YP_002403365.1 2388416 D 585055 CDS YP_002403366.1 218695699 7146804 2391494..2392909 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12107134, 21450803, 8282725; Product type t : transporter; multidrug efflux system protein MdtE 2392909 mdtD 7146804 mdtD Escherichia coli 55989 multidrug efflux system protein MdtE YP_002403366.1 2391494 D 585055 CDS YP_002403367.1 218695700 7146805 2392906..2394309 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; signal transduction histidine-protein kinase BaeS 2394309 baeS 7146805 baeS Escherichia coli 55989 signal transduction histidine-protein kinase BaeS YP_002403367.1 2392906 D 585055 CDS YP_002403368.1 218695701 7145594 2394306..2395028 1 NC_011748.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2395028 baeR 7145594 baeR Escherichia coli 55989 DNA-binding transcriptional regulator BaeR YP_002403368.1 2394306 D 585055 CDS YP_002403369.1 218695702 7145593 2395219..2395551 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2395551 yegP 7145593 yegP Escherichia coli 55989 hypothetical protein YP_002403369.1 2395219 D 585055 CDS YP_002403370.1 218695703 7148633 2395760..2396056 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2396056 7148633 EC55989_2338 Escherichia coli 55989 hypothetical protein YP_002403370.1 2395760 D 585055 CDS YP_002403371.1 218695704 7144755 2396058..2396354 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; plasmid stabilisation system protein 2396354 7144755 EC55989_2339 Escherichia coli 55989 plasmid stabilisation system protein YP_002403371.1 2396058 D 585055 CDS YP_002403372.1 218695705 7144756 2396457..2397818 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; peptidase 2397818 yegQ 7144756 yegQ Escherichia coli 55989 peptidase YP_002403372.1 2396457 D 585055 CDS YP_002403373.1 218695706 7147580 complement(2398011..2398160) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2398160 7147580 EC55989_2341 Escherichia coli 55989 hypothetical protein YP_002403373.1 2398011 R 585055 CDS YP_002403374.1 218695707 7144757 complement(2398148..2398465) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2398465 yegR 7144757 yegR Escherichia coli 55989 hypothetical protein YP_002403374.1 2398148 R 585055 CDS YP_002403375.1 218695708 7148635 2398880..2399779 1 NC_011748.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2399779 yegS 7148635 yegS Escherichia coli 55989 lipid kinase YP_002403375.1 2398880 D 585055 CDS YP_002403376.1 218695709 7148636 complement(2399861..2400640) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7772602; Product type r : regulator; Galactitol utilization operon repressor 2400640 gatR 7148636 gatR Escherichia coli 55989 Galactitol utilization operon repressor YP_002403376.1 2399861 R 585055 CDS YP_002403377.1 218695710 7146267 complement(2400740..2401780) 1 NC_011748.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase 2401780 gatD 7146267 gatD Escherichia coli 55989 galactitol-1-phosphate dehydrogenase YP_002403377.1 2400740 R 585055 CDS YP_002403378.1 218695711 7146266 complement(2401828..2403183) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76024805, 77192083, 97113438, 7772602; Product type t : transporter; PTS system galactitol-specific transporter subunit IIC 2403183 gatC 7146266 gatC Escherichia coli 55989 PTS system galactitol-specific transporter subunit IIC YP_002403378.1 2401828 R 585055 CDS YP_002403379.1 218695712 7146265 complement(2403187..2403471) 1 NC_011748.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB 2403471 gatB 7146265 gatB Escherichia coli 55989 PTS system galactitol-specific transporter subunit IIB YP_002403379.1 2403187 R 585055 CDS YP_002403380.1 218695713 7146264 complement(2403502..2403954) 1 NC_011748.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIA 2403954 gatA 7146264 gatA Escherichia coli 55989 PTS system galactitol-specific transporter subunit IIA YP_002403380.1 2403502 R 585055 CDS YP_002403381.1 218695714 7146270 complement(2405250..2406104) 1 NC_011748.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 2406104 gatY 7146270 gatY Escherichia coli 55989 tagatose-bisphosphate aldolase YP_002403381.1 2405250 R 585055 CDS YP_002403382.1 218695715 7146268 complement(2406414..2407466) 1 NC_011748.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase 2407466 fbaB 7146268 fbaB Escherichia coli 55989 fructose-bisphosphate aldolase YP_002403382.1 2406414 R 585055 CDS YP_002403383.1 218695716 7146063 2407723..2409000 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; hydrophilic substrate transporter; MFS superfamily 2409000 yegT 7146063 yegT Escherichia coli 55989 hydrophilic substrate transporter; MFS superfamily YP_002403383.1 2407723 D 585055 CDS YP_002403384.1 218695717 7148637 2408997..2410001 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; (phospho)hydrolase 2410001 yegU 7148637 yegU Escherichia coli 55989 (phospho)hydrolase YP_002403384.1 2408997 D 585055 CDS YP_002403385.1 218695718 7148638 2409998..2410963 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; kinase 2410963 yegV 7148638 yegV Escherichia coli 55989 kinase YP_002403385.1 2409998 D 585055 CDS YP_002403386.1 218695719 7148639 complement(2410937..2411683) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 2411683 yegW 7148639 yegW Escherichia coli 55989 DNA-binding transcriptional regulator YP_002403386.1 2410937 R 585055 CDS YP_002403387.1 218695720 7148640 complement(2411735..2412553) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane-bound hydrolase 2412553 yegX 7148640 yegX Escherichia coli 55989 membrane-bound hydrolase YP_002403387.1 2411735 R 585055 CDS YP_002403388.1 218695721 7148641 complement(2412618..2413418) 1 NC_011748.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase 2413418 thiD 7148641 thiD Escherichia coli 55989 phosphomethylpyrimidine kinase YP_002403388.1 2412618 R 585055 CDS YP_002403389.1 218695722 7147783 complement(2413415..2414203) 1 NC_011748.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase 2414203 thiM 7147783 thiM Escherichia coli 55989 hydroxyethylthiazole kinase YP_002403389.1 2413415 R 585055 CDS YP_002403390.1 218695723 7145308 complement(2414426..2414698) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2414698 yohL 7145308 yohL Escherichia coli 55989 hypothetical protein YP_002403390.1 2414426 R 585055 CDS YP_002403391.1 218695724 7149357 2414819..2415643 1 NC_011748.1 membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2415643 rncA 7149357 rncA Escherichia coli 55989 nickel/cobalt efflux protein RcnA YP_002403391.1 2414819 D 585055 CDS YP_002403392.1 218695725 7147446 2415682..2416200 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2416200 yohN 7147446 yohN Escherichia coli 55989 hypothetical protein YP_002403392.1 2415682 D 585055 CDS YP_002403393.1 218695726 7149358 complement(2416282..2417316) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 2417316 yehA 7149358 yehA Escherichia coli 55989 fimbrial-like adhesin protein YP_002403393.1 2416282 R 585055 CDS YP_002403394.1 218695727 7148642 complement(2417332..2419812) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; outer membrane protein 2419812 yehB 7148642 yehB Escherichia coli 55989 outer membrane protein YP_002403394.1 2417332 R 585055 CDS YP_002403395.1 218695728 7148643 complement(2419828..2420502) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; membrane-associated pilin chaperone 2420502 yehC 7148643 yehC Escherichia coli 55989 membrane-associated pilin chaperone YP_002403395.1 2419828 R 585055 CDS YP_002403396.1 218695729 7148644 complement(2420583..2421125) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 2421125 yehD 7148644 yehD Escherichia coli 55989 fimbrial-like adhesin protein YP_002403396.1 2420583 R 585055 CDS YP_002403397.1 218695730 7148645 complement(2421418..2421699) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2421699 yehE 7148645 yehE Escherichia coli 55989 hypothetical protein YP_002403397.1 2421418 R 585055 CDS YP_002403398.1 218695731 7148646 complement(2421962..2423071) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91080852, 15601724, 2259334; Product type t : transporter; ATPase 2423071 mrp 7148646 mrp Escherichia coli 55989 ATPase YP_002403398.1 2421962 R 585055 CDS YP_002403399.1 218695732 7146905 2423203..2425236 1 NC_011748.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2425236 metG 7146905 metG Escherichia coli 55989 methionyl-tRNA synthetase YP_002403399.1 2423203 D 585055 CDS YP_002403400.1 218695733 7144758 2426410..2426685 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 2426685 insA 7144758 insA Escherichia coli 55989 IS1 repressor protein InsA YP_002403400.1 2426410 D 585055 CDS YP_002403401.1 218695734 7146577 2426604..2427107 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 2427107 insB 7146577 insB Escherichia coli 55989 IS1 transposase InsAB' YP_002403401.1 2426604 D 585055 CDS YP_002403402.1 218695735 7146589 complement(2427226..2427696) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2427696 yehS 7146589 yehS Escherichia coli 55989 hypothetical protein YP_002403402.1 2427226 R 585055 CDS YP_002403403.1 218695736 7148647 complement(2427743..2428462) 1 NC_011748.1 unknown function; when overproduced it confers drug-resistance; two-component response-regulatory protein YehT 2428462 yehT 7148647 yehT Escherichia coli 55989 two-component response-regulatory protein YehT YP_002403403.1 2427743 R 585055 CDS YP_002403404.1 218695737 7148648 complement(2428459..2430144) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865, 15322361; Product type rc : receptor; sensory kinase in two-component system with YehT 2430144 yehU 7148648 yehU Escherichia coli 55989 sensory kinase in two-component system with YehT YP_002403404.1 2428459 R 585055 CDS YP_002403405.1 218695738 7148649 2430366..2431097 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11489123; Product type r : regulator; DNA-binding transcriptional regulator 2431097 mlrA 7148649 mlrA Escherichia coli 55989 DNA-binding transcriptional regulator YP_002403405.1 2430366 D 585055 CDS YP_002403406.1 218695739 7146862 2431157..2431264 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2431264 yohO 7146862 yohO Escherichia coli 55989 hypothetical protein YP_002403406.1 2431157 D 585055 CDS YP_002403407.1 218695740 7149359 complement(2431245..2431976) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: permease component of ABC superfamily transporter 2431976 yehW 7149359 yehW Escherichia coli 55989 transporter subunit: permease component of ABC superfamily transporter YP_002403407.1 2431245 R 585055 CDS YP_002403408.1 218695741 7148650 complement(2431981..2432907) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: ATP-binding component of ABC superfamily transporter 2432907 yehX 7148650 yehX Escherichia coli 55989 transporter subunit: ATP-binding component of ABC superfamily transporter YP_002403408.1 2431981 R 585055 CDS YP_002403409.1 218695742 7148651 complement(2432900..2434057) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: permease component of ABC superfamily 2434057 yehY 7148651 yehY Escherichia coli 55989 transporter subunit: permease component of ABC superfamily YP_002403409.1 2432900 R 585055 CDS YP_002403410.1 218695743 7148652 complement(2434064..2434981) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15251200; Product type pt : transporter; transporter subunit: periplasmic-binding component of ABC superfamily 2434981 yehZ 7148652 yehZ Escherichia coli 55989 transporter subunit: periplasmic-binding component of ABC superfamily YP_002403410.1 2434064 R 585055 CDS YP_002403411.1 218695744 7148653 complement(2435192..2437489) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96303506; Product type e : enzyme; beta-D-glucoside glucohydrolase, periplasmic 2437489 bglX 7148653 bglX Escherichia coli 55989 beta-D-glucoside glucohydrolase, periplasmic YP_002403411.1 2435192 R 585055 CDS YP_002403412.1 218695745 7145623 2437685..2439400 1 NC_011748.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2439400 dld 7145623 dld Escherichia coli 55989 D-lactate dehydrogenase YP_002403412.1 2437685 D 585055 CDS YP_002403413.1 218695746 7145927 complement(2439438..2440370) 1 NC_011748.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase 2440370 pbpG 7145927 pbpG Escherichia coli 55989 D-alanyl-D-alanine endopeptidase YP_002403413.1 2439438 R 585055 CDS YP_002403414.1 218695747 7147119 complement(2440544..2441131) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2441131 yohC 7147119 yohC Escherichia coli 55989 inner membrane protein YP_002403414.1 2440544 R 585055 CDS YP_002403415.1 218695748 7149351 2441301..2441879 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2441879 yohD 7149351 yohD Escherichia coli 55989 inner membrane protein YP_002403415.1 2441301 D 585055 CDS YP_002403416.1 218695749 7149352 complement(2442009..2442770) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acetoin dehydrogenase 2442770 yohF 7149352 yohF Escherichia coli 55989 acetoin dehydrogenase YP_002403416.1 2442009 R 585055 CDS YP_002403417.1 218695750 7149353 complement(2442823..2443911) 1 NC_011748.1 may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ 2443911 yohG 7149353 yohG Escherichia coli 55989 multidrug resistance outer membrane protein MdtQ YP_002403417.1 2442823 R 585055 CDS YP_002403418.1 218695751 7149354 complement(2444939..2445886) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase C 2445886 dusC 7149354 dusC Escherichia coli 55989 tRNA-dihydrouridine synthase C YP_002403418.1 2444939 R 585055 CDS YP_002403419.1 218695752 7145961 2446125..2446523 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2446523 yohJ 7145961 yohJ Escherichia coli 55989 hypothetical protein YP_002403419.1 2446125 D 585055 CDS YP_002403420.1 218695753 7149355 2446520..2447215 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2447215 yohK 7149355 yohK Escherichia coli 55989 hypothetical protein YP_002403420.1 2446520 D 585055 CDS YP_002403421.1 218695754 7149356 2447345..2448229 1 NC_011748.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2448229 cdd 7149356 cdd Escherichia coli 55989 cytidine deaminase YP_002403421.1 2447345 D 585055 CDS YP_002403422.1 218695755 7145683 2448379..2449098 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96125233, 1567863, 8550448; hypothetical protein 2449098 sanA 7145683 sanA Escherichia coli 55989 hypothetical protein YP_002403422.1 2448379 D 585055 CDS YP_002403423.1 218695756 7147600 2449101..2449340 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2449340 yeiS 7147600 yeiS Escherichia coli 55989 inner membrane protein YP_002403423.1 2449101 D 585055 CDS YP_002403424.1 218695757 7148666 2449659..2450897 1 NC_011748.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; oxidoreductase 2450897 yeiT 7148666 yeiT Escherichia coli 55989 oxidoreductase YP_002403424.1 2449659 D 585055 CDS YP_002403425.1 218695758 7148667 2450920..2452125 1 NC_011748.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2452125 yeiA 7148667 yeiA Escherichia coli 55989 dihydropyrimidine dehydrogenase YP_002403425.1 2450920 D 585055 CDS YP_002403426.1 218695759 7148654 complement(2452196..2453206) 1 NC_011748.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane protein 2453206 mglC 7148654 mglC Escherichia coli 55989 beta-methylgalactoside transporter inner membrane protein YP_002403426.1 2452196 R 585055 CDS YP_002403427.1 218695760 7146841 complement(2453222..2454742) 1 NC_011748.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein 2454742 mglA 7146841 mglA Escherichia coli 55989 galactose/methyl galaxtoside transporter ATP-binding protein YP_002403427.1 2453222 R 585055 CDS YP_002403428.1 218695761 7146839 complement(2454803..2455801) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87286407, 92049246, 1719366, 3057628, 3302609, 3600760, 6340108, 6885805, 7012152, 9298646; Product type t : transporter; methyl-galactoside transporter subunit ; periplasmic-binding component of ABC superfamily 2455801 mglB 7146839 mglB Escherichia coli 55989 methyl-galactoside transporter subunit ; periplasmic-binding component of ABC superfamily YP_002403428.1 2454803 R 585055 CDS YP_002403429.1 218695762 7146840 complement(2456081..2457121) 1 NC_011748.1 negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS 2457121 galS 7146840 galS Escherichia coli 55989 DNA-binding transcriptional regulator GalS YP_002403429.1 2456081 R 585055 CDS YP_002403430.1 218695763 7146253 2457111..2457314 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2457314 7146253 EC55989_2402 Escherichia coli 55989 hypothetical protein YP_002403430.1 2457111 D 585055 CDS YP_002403431.1 218695764 7144766 complement(2457263..2458420) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2458420 yeiB 7144766 yeiB Escherichia coli 55989 hypothetical protein YP_002403431.1 2457263 R 585055 CDS YP_002403432.1 218695765 7148655 complement(2458437..2459105) 1 NC_011748.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I 2459105 folE 7148655 folE Escherichia coli 55989 GTP cyclohydrolase I YP_002403432.1 2458437 R 585055 CDS YP_002403433.1 218695766 7146172 2459259..2459435 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2459435 7146172 EC55989_2405 Escherichia coli 55989 hypothetical protein YP_002403433.1 2459259 D 585055 CDS YP_002403434.1 218695767 7144767 2459363..2460199 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800; Product type e : enzyme; S-formylglutathione hydrolase 2460199 frmC 7144767 frmC Escherichia coli 55989 S-formylglutathione hydrolase YP_002403434.1 2459363 D 585055 CDS YP_002403435.1 218695768 7146191 complement(2460231..2462222) 1 NC_011748.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor 2462222 cirA 7146191 cirA Escherichia coli 55989 colicin I receptor YP_002403435.1 2460231 R 585055 CDS YP_002403436.1 218695769 7145708 complement(2462215..2462418) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2462418 7145708 EC55989_2408 Escherichia coli 55989 hypothetical protein YP_002403436.1 2462215 R 585055 CDS YP_002403437.1 218695770 7144768 complement(2462515..2463984) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250419, 94252996, 1315732, 7551055; Product type t : transporter; lysine transporter 2463984 lysP 7144768 lysP Escherichia coli 55989 lysine transporter YP_002403437.1 2462515 R 585055 CDS YP_002403438.1 218695771 7146757 complement(2464189..2465070) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12400704, 1315732; Product type pr : regulator; DNA-binding transcriptional regulator 2465070 yeiE 7146757 yeiE Escherichia coli 55989 DNA-binding transcriptional regulator YP_002403438.1 2464189 R 585055 CDS YP_002403439.1 218695772 7148657 2465169..2466218 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2466218 yeiH 7148657 yeiH Escherichia coli 55989 inner membrane protein YP_002403439.1 2465169 D 585055 CDS YP_002403440.1 218695773 7148658 2466292..2467149 1 NC_011748.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2467149 nfo 7148658 nfo Escherichia coli 55989 endonuclease IV YP_002403440.1 2466292 D 585055 CDS YP_002403441.1 218695774 7146987 2467153..2468241 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 2468241 yeiI 7146987 yeiI Escherichia coli 55989 hypothetical protein YP_002403441.1 2467153 D 585055 CDS YP_002403442.1 218695775 7148659 complement(2468297..2469547) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sodium/proton nucleoside transporter 2469547 yeiJ 7148659 yeiJ Escherichia coli 55989 sodium/proton nucleoside transporter YP_002403442.1 2468297 R 585055 CDS YP_002403443.1 218695776 7148660 complement(2469647..2470588) 1 NC_011748.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 2470588 rihB 7148660 rihB Escherichia coli 55989 ribonucleoside hydrolase 2 YP_002403443.1 2469647 R 585055 CDS YP_002403444.1 218695777 7147416 2470757..2471416 1 NC_011748.1 activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2471416 yeiL 7147416 yeiL Escherichia coli 55989 DNA-binding transcriptional activator YeiL YP_002403444.1 2470757 D 585055 CDS YP_002403445.1 218695778 7148661 complement(2471484..2472734) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sodium/proton nucleoside transporter 2472734 yeiM 7148661 yeiM Escherichia coli 55989 sodium/proton nucleoside transporter YP_002403445.1 2471484 R 585055 CDS YP_002403446.1 218695779 7148662 complement(2472828..2473766) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2473766 yeiN 7148662 yeiN Escherichia coli 55989 hypothetical protein YP_002403446.1 2472828 R 585055 CDS YP_002403447.1 218695780 7148663 complement(2473754..2474695) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 2474695 yeiC 7148663 yeiC Escherichia coli 55989 hypothetical protein YP_002403447.1 2473754 R 585055 CDS YP_002403448.1 218695781 7148656 complement(2475119..2476810) 1 NC_011748.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunit IIBC 2476810 fruA 7148656 fruA Escherichia coli 55989 PTS system fructose-specific transporter subunit IIBC YP_002403448.1 2475119 R 585055 CDS YP_002403449.1 218695782 7146195 complement(2476827..2477765) 1 NC_011748.1 converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase 2477765 fruK 7146195 fruK Escherichia coli 55989 1-phosphofructokinase YP_002403449.1 2476827 R 585055 CDS YP_002403450.1 218695783 7146197 complement(2477765..2478895) 1 NC_011748.1 phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein 2478895 fruB 7146197 fruB Escherichia coli 55989 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein YP_002403450.1 2477765 R 585055 CDS YP_002403451.1 218695784 7146196 2479263..2480444 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438463, 10209755; Product type t : transporter; lactose/glucose efflux system 2480444 setB 7146196 setB Escherichia coli 55989 lactose/glucose efflux system YP_002403451.1 2479263 D 585055 CDS YP_002403452.1 218695785 7147637 complement(2480441..2480827) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2480827 7147637 EC55989_2424 Escherichia coli 55989 hypothetical protein YP_002403452.1 2480441 R 585055 CDS YP_002403453.1 218695786 7144769 2480595..2481422 1 NC_011748.1 Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2481422 7144769 EC55989_2425 Escherichia coli 55989 elongation factor P YP_002403453.1 2480595 D 585055 CDS YP_002403454.1 218695787 7144770 2481645..2483111 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; sugar dehydrogenase, NAD-dependent 2483111 yeiQ 7144770 yeiQ Escherichia coli 55989 sugar dehydrogenase, NAD-dependent YP_002403454.1 2481645 D 585055 CDS YP_002403455.1 218695788 7148664 2483229..2484215 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 2484215 yeiR 7148664 yeiR Escherichia coli 55989 hypothetical protein YP_002403455.1 2483229 D 585055 CDS YP_002403456.1 218695789 7148665 2484254..2484967 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 2484967 yeiU 7148665 yeiU Escherichia coli 55989 undecaprenyl pyrophosphate phosphatase YP_002403456.1 2484254 D 585055 CDS YP_002403457.1 218695790 7148668 2485379..2485945 1 NC_011748.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance; outer membrane lipoprotein 2485945 spr 7148668 spr Escherichia coli 55989 outer membrane lipoprotein YP_002403457.1 2485379 D 585055 CDS YP_002403458.1 218695791 7147695 2486126..2487682 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2487682 rtn 7147695 rtn Escherichia coli 55989 hypothetical protein YP_002403458.1 2486126 D 585055 CDS YP_002403459.1 218695792 7147555 2487764..2489578 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; oligopeptide transporter subunit ; periplasmic-binding component of ABC superfamily transporter 2489578 yejA 7147555 yejA Escherichia coli 55989 oligopeptide transporter subunit ; periplasmic-binding component of ABC superfamily transporter YP_002403459.1 2487764 D 585055 CDS YP_002403460.1 218695793 7148669 2489579..2490673 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; oligopeptide transporter subunit; permease component of ABC superfamily 2490673 yejB 7148669 yejB Escherichia coli 55989 oligopeptide transporter subunit; permease component of ABC superfamily YP_002403460.1 2489579 D 585055 CDS YP_002403461.1 218695794 7148670 2490673..2491698 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; oligopeptide transporter subunit ; permease component of ABC superfamily transporter 2491698 yejE 7148670 yejE Escherichia coli 55989 oligopeptide transporter subunit ; permease component of ABC superfamily transporter YP_002403461.1 2490673 D 585055 CDS YP_002403462.1 218695795 7148671 2491700..2493289 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; fused oligopeptide transporter subunits of ABC superfamily: ATP-binding components 2493289 yejF 7148671 yejF Escherichia coli 55989 fused oligopeptide transporter subunits of ABC superfamily: ATP-binding components YP_002403462.1 2491700 D 585055 CDS YP_002403463.1 218695796 7148672 complement(2493293..2493637) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2493637 yejG 7148672 yejG Escherichia coli 55989 hypothetical protein YP_002403463.1 2493293 R 585055 CDS YP_002403464.1 218695797 7148673 complement(2493970..2495160) 1 NC_011748.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system protein 2495160 bcr 7148673 bcr Escherichia coli 55989 bicyclomycin/multidrug efflux system protein YP_002403464.1 2493970 R 585055 CDS YP_002403465.1 218695798 7145601 complement(2495188..2495883) 1 NC_011748.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A 2495883 rsuA 7145601 rsuA Escherichia coli 55989 16S rRNA pseudouridylate synthase A YP_002403465.1 2495188 R 585055 CDS YP_002403466.1 218695799 7147545 2496032..2497792 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; nucleic acid ATP-dependent helicase 2497792 yejH 7147545 yejH Escherichia coli 55989 nucleic acid ATP-dependent helicase YP_002403466.1 2496032 D 585055 CDS YP_002403467.1 218695800 7148674 2497917..2498201 1 NC_011748.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2498201 rplY 7148674 rplY Escherichia coli 55989 50S ribosomal protein L25 YP_002403467.1 2497917 D 585055 CDS YP_002403468.1 218695801 7147485 complement(2498340..2499347) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99296598, 10368163; Product type f : factor; nucleoid-associated protein NdpA 2499347 yejK 7147485 yejK Escherichia coli 55989 nucleoid-associated protein NdpA YP_002403468.1 2498340 R 585055 CDS YP_002403469.1 218695802 7148675 2499529..2499756 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2499756 yejL 7148675 yejL Escherichia coli 55989 hypothetical protein YP_002403469.1 2499529 D 585055 CDS YP_002403470.1 218695803 7148676 2499776..2501536 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase, inner membrane-associated 2501536 yejM 7148676 yejM Escherichia coli 55989 hydrolase, inner membrane-associated YP_002403470.1 2499776 D 585055 CDS YP_002403471.1 218695804 7145334 complement(2501666..2501827) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2501827 7145334 EC55989_2443 Escherichia coli 55989 hypothetical protein YP_002403471.1 2501666 R 585055 CDS YP_002403472.1 218695805 7148679 2504702..2505349 1 NC_011748.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2505349 narP 7148679 narP Escherichia coli 55989 transcriptional regulator NarP YP_002403472.1 2504702 D 585055 CDS YP_002403473.1 218695806 7146973 complement(2505384..2506436) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 91194558, 95362656, 9914305, 7635817; Product type pe : enzyme; heme lyase, CcmH subunit 2506436 ccmH 7146973 ccmH Escherichia coli 55989 heme lyase, CcmH subunit YP_002403473.1 2505384 R 585055 CDS YP_002403474.1 218695807 7145681 complement(2506433..2506990) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 9716493, 9770295, 11256948, 11350062, 11843181, 7635817, 9537397; Product type e : enzyme; periplasmic thioredoxin of cytochrome c-type biogenesis 2506990 ccmG 7145681 ccmG Escherichia coli 55989 periplasmic thioredoxin of cytochrome c-type biogenesis YP_002403474.1 2506433 R 585055 CDS YP_002403475.1 218695808 7145680 complement(2506987..2508930) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 8842153, 91194558, 95362656, 9716493, 7635817; Product type e : enzyme; heme lyase, CcmF subunit 2508930 ccmF 7145680 ccmF Escherichia coli 55989 heme lyase, CcmF subunit YP_002403475.1 2506987 R 585055 CDS YP_002403476.1 218695809 7145679 complement(2508927..2509406) 1 NC_011748.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE 2509406 ccmE 7145679 ccmE Escherichia coli 55989 cytochrome c-type biogenesis protein CcmE YP_002403476.1 2508927 R 585055 CDS YP_002403477.1 218695810 7145678 complement(2509403..2509612) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type f : factor; cytochrome c biogenesis protein 2509612 ccmD 7145678 ccmD Escherichia coli 55989 cytochrome c biogenesis protein YP_002403477.1 2509403 R 585055 CDS YP_002403478.1 218695811 7145677 complement(2509609..2510346) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 14532274, 21413853, 95362656, 7635817; Product type t : transporter; heme exporter subunit ; membrane component of ABC superfamily 2510346 ccmC 7145677 ccmC Escherichia coli 55989 heme exporter subunit ; membrane component of ABC superfamily YP_002403478.1 2509609 R 585055 CDS YP_002403479.1 218695812 7145676 complement(2510388..2511050) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type t : transporter; heme exporter subunit ; membrane component of ABC superfamily 2511050 ccmB 7145676 ccmB Escherichia coli 55989 heme exporter subunit ; membrane component of ABC superfamily YP_002403479.1 2510388 R 585055 CDS YP_002403480.1 218695813 7145675 complement(2511047..2511670) 1 NC_011748.1 ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA 2511670 ccmA 7145675 ccmA Escherichia coli 55989 cytochrome c biogenesis protein CcmA YP_002403480.1 2511047 R 585055 CDS YP_002403481.1 218695814 7145674 complement(2511683..2512285) 1 NC_011748.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC 2512285 napC 7145674 napC Escherichia coli 55989 cytochrome c-type protein NapC YP_002403481.1 2511683 R 585055 CDS YP_002403482.1 218695815 7146962 complement(2512295..2512744) 1 NC_011748.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit 2512744 napB 7146962 napB Escherichia coli 55989 citrate reductase cytochrome c-type subunit YP_002403482.1 2512295 R 585055 CDS YP_002403483.1 218695816 7146961 complement(2512741..2513604) 1 NC_011748.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component 2513604 napH 7146961 napH Escherichia coli 55989 quinol dehydrogenase membrane component YP_002403483.1 2512741 R 585055 CDS YP_002403484.1 218695817 7146966 complement(2513591..2514286) 1 NC_011748.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component 2514286 napG 7146966 napG Escherichia coli 55989 quinol dehydrogenase periplasmic component YP_002403484.1 2513591 R 585055 CDS YP_002403485.1 218695818 7146965 complement(2514293..2516779) 1 NC_011748.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit 2516779 napA 7146965 napA Escherichia coli 55989 nitrate reductase catalytic subunit YP_002403485.1 2514293 R 585055 CDS YP_002403486.1 218695819 7146960 complement(2516776..2517039) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96228696, 99395037; Product type f : factor; assembly protein for periplasmic nitrate reductase 2517039 napD 7146960 napD Escherichia coli 55989 assembly protein for periplasmic nitrate reductase YP_002403486.1 2516776 R 585055 CDS YP_002403487.1 218695820 7146963 complement(2517029..2517523) 1 NC_011748.1 Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA.; ferredoxin-type protein 2517523 napF 7146963 napF Escherichia coli 55989 ferredoxin-type protein YP_002403487.1 2517029 R 585055 CDS YP_002403488.1 218695821 7146964 2517623..2517796 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2517796 7146964 EC55989_2463 Escherichia coli 55989 hypothetical protein YP_002403488.1 2517623 D 585055 CDS YP_002403489.1 218695822 7144772 2517931..2518419 1 NC_011748.1 serine protease inhibitor, inhibits trypsin and other proteases; ecotin 2518419 eco 7144772 eco Escherichia coli 55989 ecotin YP_002403489.1 2517931 D 585055 CDS YP_002403490.1 218695823 7145973 complement(2518568..2520214) 1 NC_011748.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase 2520214 mqo 7145973 mqo Escherichia coli 55989 malate:quinone oxidoreductase YP_002403490.1 2518568 R 585055 CDS YP_002403491.1 218695824 7146894 complement(2520432..2522075) 1 NC_011748.1 efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane protein/ATP-binding component 2522075 yojI 7146894 yojI Escherichia coli 55989 multidrug transporter membrane protein/ATP-binding component YP_002403491.1 2520432 R 585055 CDS YP_002403492.1 218695825 7149360 complement(2522151..2522801) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12226668, 12517444, 12862460, 14527653, 87057220, 88151899, 92017669, 3536913, 3887409, 7928996; Product type e : enzyme; oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions 2522801 alkB 7149360 alkB Escherichia coli 55989 oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions YP_002403492.1 2522151 R 585055 CDS YP_002403493.1 218695826 7145482 complement(2522801..2523865) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91073391, 93272965, 94252990; Product type r : regulator; fused DNA-binding transcriptional dual regulator ; O6-methylguanine-DNA methyltransferase 2523865 ada 7145482 ada Escherichia coli 55989 fused DNA-binding transcriptional dual regulator ; O6-methylguanine-DNA methyltransferase YP_002403493.1 2522801 R 585055 CDS YP_002403494.1 218695827 7145452 complement(2523939..2524994) 1 NC_011748.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE 2524994 yojL 7145452 yojL Escherichia coli 55989 thiamine biosynthesis lipoprotein ApbE YP_002403494.1 2523939 R 585055 CDS YP_002403495.1 218695828 7149361 complement(2525106..2526209) 1 NC_011748.1 allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C 2526209 ompC 7149361 ompC Escherichia coli 55989 outer membrane porin protein C YP_002403495.1 2525106 R 585055 CDS YP_002403496.1 218695829 7146856 2526948..2529620 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 21206231, 2404948, 7984428; Product type r : regulator; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2529620 rcsD 7146856 rcsD Escherichia coli 55989 phosphotransfer intermediate protein in two-component regulatory system with RcsBC YP_002403496.1 2526948 D 585055 CDS YP_002403497.1 218695830 7147350 2529637..2530287 1 NC_011748.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2530287 rcsB 7147350 rcsB Escherichia coli 55989 transcriptional regulator RcsB YP_002403497.1 2529637 D 585055 CDS YP_002403498.1 218695831 7147348 complement(2530487..2533288) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 14651646, 20032358, 21450811, 88227838, 90130299, 92048476, 9209051, 2404948, 8366025; Product type r : regulator; hybrid sensory kinase in two-component regulatory system with RcsB and YojN 2533288 rcsC 7147348 rcsC Escherichia coli 55989 hybrid sensory kinase in two-component regulatory system with RcsB and YojN YP_002403498.1 2530487 R 585055 CDS YP_002403499.1 218695832 7147349 complement(2533611..2534387) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2534387 yfaP 7147349 yfaP Escherichia coli 55989 hypothetical protein YP_002403499.1 2533611 R 585055 CDS YP_002403500.1 218695833 7148686 complement(2534392..2536041) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2536041 yfaQ 7148686 yfaQ Escherichia coli 55989 hypothetical protein YP_002403500.1 2534392 R 585055 CDS YP_002403501.1 218695834 7148687 complement(2536042..2540661) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; large extracellular alpha-helical protein 2540661 7148687 EC55989_2476 Escherichia coli 55989 large extracellular alpha-helical protein YP_002403501.1 2536042 R 585055 CDS YP_002403502.1 218695835 7144773 complement(2540580..2541203) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2541203 yfaT 7144773 yfaT Escherichia coli 55989 hypothetical protein YP_002403502.1 2540580 R 585055 CDS YP_002403503.1 218695836 7148688 complement(2541200..2542888) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2542888 yfaA 7148688 yfaA Escherichia coli 55989 hypothetical protein YP_002403503.1 2541200 R 585055 CDS YP_002403504.1 218695837 7148680 complement(2543037..2545664) 1 NC_011748.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A 2545664 gyrA 7148680 gyrA Escherichia coli 55989 DNA gyrase subunit A YP_002403504.1 2543037 R 585055 CDS YP_002403505.1 218695838 7146388 2545811..2546533 1 NC_011748.1 Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2546533 ubiG 7146388 ubiG Escherichia coli 55989 3-demethylubiquinone-9 3-methyltransferase YP_002403505.1 2545811 D 585055 CDS YP_002403506.1 218695839 7147893 complement(2546661..2550395) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659678; Product type f : factor; adhesin 2550395 yfaL 7147893 yfaL Escherichia coli 55989 adhesin YP_002403506.1 2546661 R 585055 CDS YP_002403507.1 218695840 7148684 2551091..2553376 1 NC_011748.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2553376 nrdA 7148684 nrdA Escherichia coli 55989 ribonucleotide-diphosphate reductase subunit alpha YP_002403507.1 2551091 D 585055 CDS YP_002403508.1 218695841 7147018 2553465..2554595 1 NC_011748.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2554595 nrdB 7147018 nrdB Escherichia coli 55989 ribonucleotide-diphosphate reductase subunit beta YP_002403508.1 2553465 D 585055 CDS YP_002403509.1 218695842 7147019 2554595..2554849 1 NC_011748.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin 2554849 yfaE 7147019 yfaE Escherichia coli 55989 2Fe-2S ferredoxin YP_002403509.1 2554595 D 585055 CDS YP_002403510.1 218695843 7148682 complement(2554903..2555553) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165728, 1537798, 6087316; hypothetical protein 2555553 inaA 7148682 inaA Escherichia coli 55989 hypothetical protein YP_002403510.1 2554903 R 585055 CDS YP_002403511.1 218695844 7144774 2555768..2555974 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2555974 yfaH 7144774 yfaH Escherichia coli 55989 hypothetical protein YP_002403511.1 2555768 D 585055 CDS YP_002403512.1 218695845 7148683 complement(2556016..2557092) 1 NC_011748.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase 2557092 glpQ 7148683 glpQ Escherichia coli 55989 glycerophosphodiester phosphodiesterase YP_002403512.1 2556016 R 585055 CDS YP_002403513.1 218695846 7146323 complement(2557097..2558455) 1 NC_011748.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter 2558455 glpT 7146323 glpT Escherichia coli 55989 sn-glycerol-3-phosphate transporter YP_002403513.1 2557097 R 585055 CDS YP_002403514.1 218695847 7146325 2558728..2560356 1 NC_011748.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2560356 glpA 7146325 glpA Escherichia coli 55989 sn-glycerol-3-phosphate dehydrogenase subunit A YP_002403514.1 2558728 D 585055 CDS YP_002403515.1 218695848 7146315 2560346..2561605 1 NC_011748.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2561605 glpB 7146315 glpB Escherichia coli 55989 anaerobic glycerol-3-phosphate dehydrogenase subunit B YP_002403515.1 2560346 D 585055 CDS YP_002403516.1 218695849 7146316 2561602..2562792 1 NC_011748.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2562792 glpC 7146316 glpC Escherichia coli 55989 sn-glycerol-3-phosphate dehydrogenase subunit C YP_002403516.1 2561602 D 585055 CDS YP_002403517.1 218695850 7146317 2562986..2563888 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2563888 yfaD 7146317 yfaD Escherichia coli 55989 hypothetical protein YP_002403517.1 2562986 D 585055 CDS YP_002403518.1 218695851 7148689 complement(2564454..2565656) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A 2565656 yfaY 7148689 yfaY Escherichia coli 55989 competence damage-inducible protein A YP_002403518.1 2564454 R 585055 CDS YP_002403519.1 218695852 7148690 complement(2565756..2566298) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; outer membrane porin protein 2566298 yfaZ 7148690 yfaZ Escherichia coli 55989 outer membrane porin protein YP_002403519.1 2565756 R 585055 CDS YP_002403520.1 218695853 7148691 2566577..2567002 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : enzyme; NUDIX hydrolase 2567002 yfaO 7148691 yfaO Escherichia coli 55989 NUDIX hydrolase YP_002403520.1 2566577 D 585055 CDS YP_002403521.1 218695854 7148685 complement(2567041..2567643) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2567643 ais 7148685 ais Escherichia coli 55989 hypothetical protein YP_002403521.1 2567041 R 585055 CDS YP_002403522.1 218695855 7145477 2567933..2569090 1 NC_011748.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2569090 yfbE 7145477 yfbE Escherichia coli 55989 UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase YP_002403522.1 2567933 D 585055 CDS YP_002403523.1 218695856 7148693 2569094..2570062 1 NC_011748.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2570062 yfbF 7148693 yfbF Escherichia coli 55989 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase YP_002403523.1 2569094 D 585055 CDS YP_002403524.1 218695857 7148694 2570062..2572044 1 NC_011748.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2572044 yfbG 7148694 yfbG Escherichia coli 55989 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase YP_002403524.1 2570062 D 585055 CDS YP_002403525.1 218695858 7148695 2572041..2572931 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2572931 yfbH 7148695 yfbH Escherichia coli 55989 hypothetical protein YP_002403525.1 2572041 D 585055 CDS YP_002403526.1 218695859 7148696 2572931..2574583 1 NC_011748.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2574583 arnT 7148696 arnT Escherichia coli 55989 4-amino-4-deoxy-L-arabinose transferase YP_002403526.1 2572931 D 585055 CDS YP_002403527.1 218695860 7145538 2574580..2574915 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; inner membrane protein 2574915 yfbW 7145538 yfbW Escherichia coli 55989 inner membrane protein YP_002403527.1 2574580 D 585055 CDS YP_002403528.1 218695861 7148705 2574915..2575301 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2575301 yfbJ 7148705 yfbJ Escherichia coli 55989 hypothetical protein YP_002403528.1 2574915 D 585055 CDS YP_002403529.1 218695862 7148697 complement(2575295..2575561) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96015440, 15569938; Product type pt : transporter; polymyxin resistance protein B 2575561 pmrD 7148697 pmrD Escherichia coli 55989 polymyxin resistance protein B YP_002403529.1 2575295 R 585055 CDS YP_002403530.1 218695863 7147200 complement(2575671..2577026) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96186953, 8626063; Product type e : enzyme; O-succinylbenzoic acid--CoA ligase 2577026 menE 7147200 menE Escherichia coli 55989 O-succinylbenzoic acid--CoA ligase YP_002403530.1 2575671 R 585055 CDS YP_002403531.1 218695864 7146821 complement(2577023..2577985) 1 NC_011748.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase 2577985 menC 7146821 menC Escherichia coli 55989 O-succinylbenzoate synthase YP_002403531.1 2577023 R 585055 CDS YP_002403532.1 218695865 7146819 complement(2577985..2578842) 1 NC_011748.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase 2578842 menB 7146819 menB Escherichia coli 55989 naphthoate synthase YP_002403532.1 2577985 R 585055 CDS YP_002403533.1 218695866 7146818 complement(2578857..2579615) 1 NC_011748.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase 2579615 yfbB 7146818 yfbB Escherichia coli 55989 acyl-CoA thioester hydrolase YP_002403533.1 2578857 R 585055 CDS YP_002403534.1 218695867 7148692 complement(2579612..2581282) 1 NC_011748.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase 2581282 menD 7148692 menD Escherichia coli 55989 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase YP_002403534.1 2579612 R 585055 CDS YP_002403535.1 218695868 7146820 complement(2581371..2582666) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150206, 96140724, 2666397, 7984428, 8549818, 8764478; Product type e : enzyme; isochorismate synthase 2 2582666 menF 7146820 menF Escherichia coli 55989 isochorismate synthase 2 YP_002403535.1 2581371 R 585055 CDS YP_002403536.1 218695869 7146822 complement(2582745..2583050) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2583050 elaB 7146822 elaB Escherichia coli 55989 hypothetical protein YP_002403536.1 2582745 R 585055 CDS YP_002403537.1 218695870 7145984 complement(2583105..2583566) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 2583566 elaA 7145984 elaA Escherichia coli 55989 hypothetical protein YP_002403537.1 2583105 R 585055 CDS YP_002403538.1 218695871 7145983 2583631..2584548 1 NC_011748.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2584548 elaC 7145983 elaC Escherichia coli 55989 ribonuclease Z YP_002403538.1 2583631 D 585055 CDS YP_002403539.1 218695872 7145985 2584736..2585956 1 NC_011748.1 ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system; deubiquitinase 2585956 elaD 7145985 elaD Escherichia coli 55989 deubiquitinase YP_002403539.1 2584736 D 585055 CDS YP_002403540.1 218695873 7145986 2586601..2586951 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Zn-dependent exopeptidases 2586951 7145986 EC55989_2518 Escherichia coli 55989 Zn-dependent exopeptidases YP_002403540.1 2586601 D 585055 CDS YP_002403541.1 218695874 7144775 2587077..2587580 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2587580 yfbM 7144775 yfbM Escherichia coli 55989 hypothetical protein YP_002403541.1 2587077 D 585055 CDS YP_002403542.1 218695875 7148698 complement(2587647..2589104) 1 NC_011748.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N 2589104 nuoN 7148698 nuoN Escherichia coli 55989 NADH dehydrogenase subunit N YP_002403542.1 2587647 R 585055 CDS YP_002403543.1 218695876 7147055 complement(2589111..2590640) 1 NC_011748.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M 2590640 nuoM 7147055 nuoM Escherichia coli 55989 NADH dehydrogenase subunit M YP_002403543.1 2589111 R 585055 CDS YP_002403544.1 218695877 7147054 complement(2590804..2592645) 1 NC_011748.1 Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L 2592645 nuoL 7147054 nuoL Escherichia coli 55989 NADH dehydrogenase subunit L YP_002403544.1 2590804 R 585055 CDS YP_002403545.1 218695878 7147053 complement(2592642..2592944) 1 NC_011748.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K 2592944 nuoK 7147053 nuoK Escherichia coli 55989 NADH dehydrogenase subunit K YP_002403545.1 2592642 R 585055 CDS YP_002403546.1 218695879 7147052 complement(2592941..2593495) 1 NC_011748.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J 2593495 nuoJ 7147052 nuoJ Escherichia coli 55989 NADH dehydrogenase subunit J YP_002403546.1 2592941 R 585055 CDS YP_002403547.1 218695880 7147051 complement(2593507..2594049) 1 NC_011748.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I 2594049 nuoI 7147051 nuoI Escherichia coli 55989 NADH dehydrogenase subunit I YP_002403547.1 2593507 R 585055 CDS YP_002403548.1 218695881 7147050 complement(2594064..2595041) 1 NC_011748.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H 2595041 nuoH 7147050 nuoH Escherichia coli 55989 NADH dehydrogenase subunit H YP_002403548.1 2594064 R 585055 CDS YP_002403549.1 218695882 7147049 complement(2595038..2597770) 1 NC_011748.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G 2597770 nuoG 7147049 nuoG Escherichia coli 55989 NADH dehydrogenase subunit G YP_002403549.1 2595038 R 585055 CDS YP_002403550.1 218695883 7147048 complement(2597817..2599154) 1 NC_011748.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F 2599154 nuoF 7147048 nuoF Escherichia coli 55989 NADH dehydrogenase I subunit F YP_002403550.1 2597817 R 585055 CDS YP_002403551.1 218695884 7147047 complement(2599151..2599651) 1 NC_011748.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E 2599651 nuoE 7147047 nuoE Escherichia coli 55989 NADH dehydrogenase subunit E YP_002403551.1 2599151 R 585055 CDS YP_002403552.1 218695885 7147046 complement(2599654..2601456) 1 NC_011748.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D 2601456 nuoC 7147046 nuoC Escherichia coli 55989 bifunctional NADH:ubiquinone oxidoreductase subunit C/D YP_002403552.1 2599654 R 585055 CDS YP_002403553.1 218695886 7147045 complement(2601550..2602212) 1 NC_011748.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B 2602212 nuoB 7147045 nuoB Escherichia coli 55989 NADH dehydrogenase subunit B YP_002403553.1 2601550 R 585055 CDS YP_002403554.1 218695887 7147044 complement(2602228..2602671) 1 NC_011748.1 Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A 2602671 nuoA 7147044 nuoA Escherichia coli 55989 NADH dehydrogenase subunit A YP_002403554.1 2602228 R 585055 CDS YP_002403555.1 218695888 7147043 complement(2603302..2604240) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123461, 9882671, 7565112; Product type r : regulator; DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes 2604240 lrhA 7147043 lrhA Escherichia coli 55989 DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes YP_002403555.1 2603302 R 585055 CDS YP_002403556.1 218695889 7146743 2605160..2606377 1 NC_011748.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 2606377 yfbQ 7146743 yfbQ Escherichia coli 55989 aminotransferase YP_002403556.1 2605160 D 585055 CDS YP_002403557.1 218695890 7148699 2606461..2607060 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489502; Product type e : enzyme; hypothetical protein 2607060 yfbR 7148699 yfbR Escherichia coli 55989 hypothetical protein YP_002403557.1 2606461 D 585055 CDS YP_002403558.1 218695891 7148700 complement(2607119..2608951) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 2608951 yfbS 7148700 yfbS Escherichia coli 55989 transporter YP_002403558.1 2607119 R 585055 CDS YP_002403559.1 218695892 7148701 complement(2609038..2609688) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; phosphatase 2609688 yfbT 7148701 yfbT Escherichia coli 55989 phosphatase YP_002403559.1 2609038 R 585055 CDS YP_002403560.1 218695893 7148702 complement(2609699..2610193) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2610193 yfbU 7148702 yfbU Escherichia coli 55989 hypothetical protein YP_002403560.1 2609699 R 585055 CDS YP_002403561.1 218695894 7148703 complement(2610276..2610731) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2610731 yfbV 7148703 yfbV Escherichia coli 55989 hypothetical protein YP_002403561.1 2610276 R 585055 CDS YP_002403562.1 218695895 7148704 2611069..2612271 1 NC_011748.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2612271 ackA 7148704 ackA Escherichia coli 55989 acetate kinase YP_002403562.1 2611069 D 585055 CDS YP_002403563.1 218695896 7145437 2612346..2614490 1 NC_011748.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2614490 pta 7145437 pta Escherichia coli 55989 phosphate acetyltransferase YP_002403563.1 2612346 D 585055 CDS YP_002403564.1 218695897 7147281 2614680..2616200 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pc : carrier; hypothetical protein 2616200 yfcC 7147281 yfcC Escherichia coli 55989 hypothetical protein YP_002403564.1 2614680 D 585055 CDS YP_002403565.1 218695898 7148707 complement(2616233..2616775) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : enzyme; NUDIX hydrolase 2616775 yfcD 7148707 yfcD Escherichia coli 55989 NUDIX hydrolase YP_002403565.1 2616233 R 585055 CDS YP_002403566.1 218695899 7148708 complement(2616833..2617387) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; phosphodiesterase 2617387 yfcE 7148708 yfcE Escherichia coli 55989 phosphodiesterase YP_002403566.1 2616833 R 585055 CDS YP_002403567.1 218695900 7148709 complement(2617440..2618084) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 2618084 yfcF 7148709 yfcF Escherichia coli 55989 hypothetical protein YP_002403567.1 2617440 R 585055 CDS YP_002403568.1 218695901 7148710 2618220..2618867 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; glutathione S-transferase 2618867 yfcG 7148710 yfcG Escherichia coli 55989 glutathione S-transferase YP_002403568.1 2618220 D 585055 CDS YP_002403569.1 218695902 7148711 2618924..2619286 1 NC_011748.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2619286 folX 7148711 folX Escherichia coli 55989 D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase YP_002403569.1 2618924 D 585055 CDS YP_002403570.1 218695903 7146176 2619307..2620200 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : enzyme; NAD(P)-binding Rossmann-fold domain 2620200 yfcH 7146176 yfcH Escherichia coli 55989 NAD(P)-binding Rossmann-fold domain YP_002403570.1 2619307 D 585055 CDS YP_002403571.1 218695904 7148712 complement(2620248..2621150) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase 2621150 yfcI 7148712 yfcI Escherichia coli 55989 transposase YP_002403571.1 2620248 R 585055 CDS YP_002403572.1 218695905 7148713 complement(2621347..2622120) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284, 91060556; Product type t : transporter; histidine/lysine/arginine/ornithine transporter subunit 2622120 hisP 7148713 hisP Escherichia coli 55989 histidine/lysine/arginine/ornithine transporter subunit YP_002403572.1 2621347 R 585055 CDS YP_002403573.1 218695906 7146441 complement(2622128..2622844) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284; Product type t : transporter; histidine/lysine/arginine/ornithine transporter subunit ; membrane component of ABC superfamily 2622844 hisM 7146441 hisM Escherichia coli 55989 histidine/lysine/arginine/ornithine transporter subunit ; membrane component of ABC superfamily YP_002403573.1 2622128 R 585055 CDS YP_002403574.1 218695907 7146440 complement(2622841..2623527) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434; Product type t : transporter; histidine/lysine/arginine/ornithine transporter subunit ; membrane component of ABC superfamily 2623527 hisQ 7146440 hisQ Escherichia coli 55989 histidine/lysine/arginine/ornithine transporter subunit ; membrane component of ABC superfamily YP_002403574.1 2622841 R 585055 CDS YP_002403575.1 218695908 7146442 complement(2623617..2624399) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 6449635, 8161536, 9298646, 9600841, 9740056; Product type t : transporter; histidine/lysine/arginine/ornithine transporter subunit ; periplasmic-binding component of ABC superfamily 2624399 hisJ 7146442 hisJ Escherichia coli 55989 histidine/lysine/arginine/ornithine transporter subunit ; periplasmic-binding component of ABC superfamily YP_002403575.1 2623617 R 585055 CDS YP_002403576.1 218695909 7146438 complement(2624620..2625402) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4583243, 87308226, 3040734, 9298646; Product type t : transporter; lysine/arginine/ornithine transporter subunit ; periplasmic-binding component of ABC superfamily 2625402 argT 7146438 argT Escherichia coli 55989 lysine/arginine/ornithine transporter subunit ; periplasmic-binding component of ABC superfamily YP_002403576.1 2624620 R 585055 CDS YP_002403577.1 218695910 7145537 complement(2625668..2626237) 1 NC_011748.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 2626237 ubiX 7145537 ubiX Escherichia coli 55989 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_002403577.1 2625668 R 585055 CDS YP_002403578.1 218695911 7147895 complement(2626332..2627849) 1 NC_011748.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase 2627849 purF 7147895 purF Escherichia coli 55989 amidophosphoribosyltransferase YP_002403578.1 2626332 R 585055 CDS YP_002403579.1 218695912 7147297 complement(2627886..2628374) 1 NC_011748.1 membrane protein required for colicin V production; colicin V production protein 2628374 cvpA 7147297 cvpA Escherichia coli 55989 colicin V production protein YP_002403579.1 2627886 R 585055 CDS YP_002403580.1 218695913 7145800 complement(2628633..2629295) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3040734; hypothetical protein 2629295 dedD 7145800 dedD Escherichia coli 55989 hypothetical protein YP_002403580.1 2628633 R 585055 CDS YP_002403581.1 218695914 7145877 complement(2629285..2630553) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3040739, 91112811, 92041808, 1989505, 3040734; Product type e : enzyme; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase 2630553 folC 7145877 folC Escherichia coli 55989 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase YP_002403581.1 2629285 R 585055 CDS YP_002403582.1 218695915 7146170 complement(2630623..2631537) 1 NC_011748.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta 2631537 accD 7146170 accD Escherichia coli 55989 acetyl-CoA carboxylase subunit beta YP_002403582.1 2630623 R 585055 CDS YP_002403583.1 218695916 7145431 complement(2631693..2632352) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029016, 3040734, 7678242; Product type pm : membrane component; hypothetical protein 2632352 dedA 7145431 dedA Escherichia coli 55989 hypothetical protein YP_002403583.1 2631693 R 585055 CDS YP_002403584.1 218695917 7145876 complement(2632435..2633247) 1 NC_011748.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A 2633247 truA 7145876 truA Escherichia coli 55989 tRNA pseudouridine synthase A YP_002403584.1 2632435 R 585055 CDS YP_002403585.1 218695918 7147858 complement(2633247..2634260) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 92380957, 92380982, 93123150, 2681152, 2991861, 3029016; Product type pe : enzyme; semialdehyde dehydrogenase 2634260 usg 7147858 usg Escherichia coli 55989 semialdehyde dehydrogenase YP_002403585.1 2633247 R 585055 CDS YP_002403586.1 218695919 7147926 complement(2634326..2635462) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90036695, 91035267, 2681152, 2991861, 3029016; Product type e : enzyme; erythronate-4-phosphate dehydrogenase 2635462 pdxB 7147926 pdxB Escherichia coli 55989 erythronate-4-phosphate dehydrogenase YP_002403586.1 2634326 R 585055 CDS YP_002403587.1 218695920 7147125 2635561..2636556 1 NC_011748.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2636556 flk 7147125 flk Escherichia coli 55989 flagella biosynthesis regulator YP_002403587.1 2635561 D 585055 CDS YP_002403588.1 218695921 7146162 complement(2636553..2637731) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; hypothetical protein 2637731 yfcJ 7146162 yfcJ Escherichia coli 55989 hypothetical protein YP_002403588.1 2636553 R 585055 CDS YP_002403589.1 218695922 7148714 complement(2638024..2639244) 1 NC_011748.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 2639244 fabB 7148714 fabB Escherichia coli 55989 3-oxoacyl-ACP synthase YP_002403589.1 2638024 R 585055 CDS YP_002403590.1 218695923 7146047 2639403..2641409 1 NC_011748.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2641409 mnmC 7146047 mnmC Escherichia coli 55989 5-methylaminomethyl-2-thiouridine methyltransferase YP_002403590.1 2639403 D 585055 CDS YP_002403591.1 218695924 7147845 complement(2641530..2641808) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2641808 yfcL 7147845 yfcL Escherichia coli 55989 hypothetical protein YP_002403591.1 2641530 R 585055 CDS YP_002403592.1 218695925 7148715 complement(2641842..2642390) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2642390 yfcM 7148715 yfcM Escherichia coli 55989 hypothetical protein YP_002403592.1 2641842 R 585055 CDS YP_002403593.1 218695926 7148716 complement(2642390..2643199) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2643199 yfcA 7148716 yfcA Escherichia coli 55989 hypothetical protein YP_002403593.1 2642390 R 585055 CDS YP_002403594.1 218695927 7148706 complement(2643199..2644023) 1 NC_011748.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase 2644023 mepA 7148706 mepA Escherichia coli 55989 penicillin-insensitive murein endopeptidase YP_002403594.1 2643199 R 585055 CDS YP_002403595.1 218695928 7146823 complement(2644027..2645112) 1 NC_011748.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase 2645112 aroC 7146823 aroC Escherichia coli 55989 chorismate synthase YP_002403595.1 2644027 R 585055 CDS YP_002403596.1 218695929 7145541 complement(2645147..2646079) 1 NC_011748.1 involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 2646079 prmB 7145541 prmB Escherichia coli 55989 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase YP_002403596.1 2645147 R 585055 CDS YP_002403597.1 218695930 7147250 2646245..2646796 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2646796 yfcN 7147250 yfcN Escherichia coli 55989 hypothetical protein YP_002403597.1 2646245 D 585055 CDS YP_002403598.1 218695931 7148717 complement(2646990..2647970) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 2647970 7148717 EC55989_2576 Escherichia coli 55989 transposase, IS110 family YP_002403598.1 2646990 R 585055 CDS YP_002403599.1 218695932 7144776 complement(2648197..2649069) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2649069 7144776 EC55989_2577 Escherichia coli 55989 hypothetical protein YP_002403599.1 2648197 R 585055 CDS YP_002403600.1 218695933 7144777 complement(2649056..2649580) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial protein (Adhesin) 2649580 7144777 EC55989_2578 Escherichia coli 55989 fimbrial protein (Adhesin) YP_002403600.1 2649056 R 585055 CDS YP_002403601.1 218695934 7144778 complement(2649577..2650047) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial protein 2650047 7144778 EC55989_2579 Escherichia coli 55989 fimbrial protein YP_002403601.1 2649577 R 585055 CDS YP_002403602.1 218695935 7144779 complement(2650044..2650658) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; minor fimbrial subunit 2650658 7144779 EC55989_2580 Escherichia coli 55989 minor fimbrial subunit YP_002403602.1 2650044 R 585055 CDS YP_002403603.1 218695936 7144780 complement(2650567..2651319) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; periplasmic pilus chaperone 2651319 yfcS 7144780 yfcS Escherichia coli 55989 periplasmic pilus chaperone YP_002403603.1 2650567 R 585055 CDS YP_002403604.1 218695937 7148718 complement(2651339..2653981) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; outer membrane usher protein yfcU precursor 2653981 7148718 EC55989_2582 Escherichia coli 55989 outer membrane usher protein yfcU precursor YP_002403604.1 2651339 R 585055 CDS YP_002403605.1 218695938 7144781 complement(2654063..2654626) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 2654626 yfcV 7144781 yfcV Escherichia coli 55989 fimbrial-like adhesin protein YP_002403605.1 2654063 R 585055 CDS YP_002403606.1 218695939 7148719 complement(2655301..2655786) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10089421, 20200300, 9489669; Product type e : enzyme; phosphohistidine phosphatase 2655786 sixA 7148719 sixA Escherichia coli 55989 phosphohistidine phosphatase YP_002403606.1 2655301 R 585055 CDS YP_002403607.1 218695940 7147659 complement(2655989..2658133) 1 NC_011748.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha 2658133 fadJ 7147659 fadJ Escherichia coli 55989 multifunctional fatty acid oxidation complex subunit alpha YP_002403607.1 2655989 R 585055 CDS YP_002403608.1 218695941 7148720 complement(2658133..2659443) 1 NC_011748.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase 2659443 fadI 7148720 fadI Escherichia coli 55989 3-ketoacyl-CoA thiolase YP_002403608.1 2658133 R 585055 CDS YP_002403609.1 218695942 7148721 complement(2659623..2659907) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2659907 yfcZ 7148721 yfcZ Escherichia coli 55989 hypothetical protein YP_002403609.1 2659623 R 585055 CDS YP_002403610.1 218695943 7148722 2660273..2661619 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15178802, 2840553, 3286621, 91100327, 1987139, 9119048; Product type t : transporter; long-chain fatty acid outer membrane transporter 2661619 fadL 7148722 fadL Escherichia coli 55989 long-chain fatty acid outer membrane transporter YP_002403610.1 2660273 D 585055 CDS YP_002403611.1 218695944 7146060 2661985..2663043 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2663043 yfdF 7146060 yfdF Escherichia coli 55989 hypothetical protein YP_002403611.1 2661985 D 585055 CDS YP_002403612.1 218695945 7148725 complement(2663225..2663980) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8145644, 15352239; Product type lp : lipoprotein; lipoprotein 2663980 vacJ 7148725 vacJ Escherichia coli 55989 lipoprotein YP_002403612.1 2663225 R 585055 CDS YP_002403613.1 218695946 7147945 complement(2664006..2664176) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 2664176 7147945 EC55989_2591 Escherichia coli 55989 hypothetical protein YP_002403613.1 2664006 R 585055 CDS YP_002403614.1 218695947 7144782 2664274..2665206 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2665206 yfdC 7144782 yfdC Escherichia coli 55989 inner membrane protein YP_002403614.1 2664274 D 585055 CDS YP_002403615.1 218695948 7145335 2665518..2666675 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; prophage CPS-53 integrase; CPS-53 (KpLE1) prophage 2666675 intS 7145335 intS Escherichia coli 55989 prophage CPS-53 integrase; CPS-53 (KpLE1) prophage YP_002403615.1 2665518 D 585055 CDS YP_002403616.1 218695949 7146610 2666884..2668806 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2668806 7146610 EC55989_2594 Escherichia coli 55989 hypothetical protein YP_002403616.1 2666884 D 585055 CDS YP_002403617.1 218695950 7144783 complement(2668877..2670856) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein; head-binding domain 2670856 7144783 EC55989_2595 Escherichia coli 55989 hypothetical protein; head-binding domain YP_002403617.1 2668877 R 585055 CDS YP_002403618.1 218695951 7144784 2670908..2671246 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; regulatory protein mnt (modular protein) 2671246 7144784 EC55989_2596 Escherichia coli 55989 regulatory protein mnt (modular protein) YP_002403618.1 2670908 D 585055 CDS YP_002403619.1 218695952 7144785 complement(2671482..2672261) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2672261 7144785 EC55989_2597 Escherichia coli 55989 hypothetical protein YP_002403619.1 2671482 R 585055 CDS YP_002403620.1 218695953 7144786 complement(2672299..2673009) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2673009 7144786 EC55989_2598 Escherichia coli 55989 hypothetical protein YP_002403620.1 2672299 R 585055 CDS YP_002403621.1 218695954 7144787 complement(2672999..2673187) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; transcriptional repressor arc (modular protein) 2673187 7144787 EC55989_2599 Escherichia coli 55989 transcriptional repressor arc (modular protein) YP_002403621.1 2672999 R 585055 CDS YP_002403622.1 218695955 7144788 2673284..2673604 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; regulator protein; Arc-like DNA binding domain 2673604 7144788 EC55989_2600 Escherichia coli 55989 regulator protein; Arc-like DNA binding domain YP_002403622.1 2673284 D 585055 CDS YP_002403623.1 218695956 7144789 2673688..2673882 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2673882 7144789 EC55989_2601 Escherichia coli 55989 hypothetical protein YP_002403623.1 2673688 D 585055 CDS YP_002403624.1 218695957 7144790 complement(2673896..2674261) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2674261 7144790 EC55989_2602 Escherichia coli 55989 hypothetical protein YP_002403624.1 2673896 R 585055 CDS YP_002403625.1 218695958 7144792 complement(2676624..2677967) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA transfer protein gp20 2677967 gp 7144792 gp Escherichia coli 55989 DNA transfer protein gp20 YP_002403625.1 2676624 R 585055 CDS YP_002403626.1 218695959 7146357 complement(2677978..2678670) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA transfer protein 2678670 7146357 EC55989_2605 Escherichia coli 55989 DNA transfer protein YP_002403626.1 2677978 R 585055 CDS YP_002403627.1 218695960 7144793 complement(2678673..2679131) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Head assembly protein 2679131 7144793 EC55989_2606 Escherichia coli 55989 Head assembly protein YP_002403627.1 2678673 R 585055 CDS YP_002403628.1 218695961 7144794 complement(2679128..2679976) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Packaged DNA stabilization protein gp26 2679976 GP 7144794 GP Escherichia coli 55989 Packaged DNA stabilization protein gp26 YP_002403628.1 2679128 R 585055 CDS YP_002403629.1 218695962 7146358 complement(2679976..2681394) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Packaged DNA stabilization protein from phage 2681394 7146358 EC55989_2608 Escherichia coli 55989 Packaged DNA stabilization protein from phage YP_002403629.1 2679976 R 585055 CDS YP_002403630.1 218695963 7144795 complement(2681403..2681885) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; packaged DNA stabilization protein p27 2681885 7144795 EC55989_2609 Escherichia coli 55989 packaged DNA stabilization protein p27 YP_002403630.1 2681403 R 585055 CDS YP_002403631.1 218695964 7144796 complement(2681860..2682045) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 2682045 7144796 EC55989_2610 Escherichia coli 55989 phage protein YP_002403631.1 2681860 R 585055 CDS YP_002403632.1 218695965 7144797 complement(2682088..2683359) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major head protein (p24) (Major coat protein) 2683359 p 7144797 p Escherichia coli 55989 Major head protein (p24) (Major coat protein) YP_002403632.1 2682088 R 585055 CDS YP_002403633.1 218695966 7147091 complement(2683371..2684255) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; scaffold protein 2684255 7147091 EC55989_2612 Escherichia coli 55989 scaffold protein YP_002403633.1 2683371 R 585055 CDS YP_002403634.1 218695967 7144798 complement(2684269..2686467) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; portal protein p19 2686467 7144798 EC55989_2613 Escherichia coli 55989 portal protein p19 YP_002403634.1 2684269 R 585055 CDS YP_002403635.1 218695968 7144799 complement(2686398..2687810) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Terminase large subunit 2687810 7144799 EC55989_2614 Escherichia coli 55989 Terminase large subunit YP_002403635.1 2686398 R 585055 CDS YP_002403636.1 218695969 7144800 complement(2687807..2688232) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; terminase small subunit 2688232 7144800 EC55989_2615 Escherichia coli 55989 terminase small subunit YP_002403636.1 2687807 R 585055 CDS YP_002403637.1 218695970 7144801 complement(2688312..2688554) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2688554 7144801 EC55989_2616 Escherichia coli 55989 hypothetical protein YP_002403637.1 2688312 R 585055 CDS YP_002403638.1 218695971 7144802 complement(2688658..2689038) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 2689038 7144802 EC55989_2617 Escherichia coli 55989 phage protein YP_002403638.1 2688658 R 585055 CDS YP_002403639.1 218695972 7144803 complement(2689272..2689751) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2689751 7144803 EC55989_2618 Escherichia coli 55989 hypothetical protein YP_002403639.1 2689272 R 585055 CDS YP_002403640.1 218695973 7144804 complement(2689973..2690422) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; bacteriophage lysis protein 2690422 7144804 EC55989_2619 Escherichia coli 55989 bacteriophage lysis protein YP_002403640.1 2689973 R 585055 CDS YP_002403641.1 218695974 7144805 complement(2690407..2690904) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3017988; Product type pe : enzyme; lysozyme; DLP12 prophage 2690904 ybcS 7144805 ybcS Escherichia coli 55989 lysozyme; DLP12 prophage YP_002403641.1 2690407 R 585055 CDS YP_002403642.1 218695975 7148136 complement(2690882..2691085) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2691085 7148136 EC55989_2621 Escherichia coli 55989 hypothetical protein YP_002403642.1 2690882 R 585055 CDS YP_002403643.1 218695976 7144807 2691570..2691842 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2691842 7144807 EC55989_2624 Escherichia coli 55989 hypothetical protein YP_002403643.1 2691570 D 585055 CDS YP_002403644.1 218695977 7144808 complement(2691876..2692364) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage antitermination protein Q 2692364 7144808 EC55989_2625 Escherichia coli 55989 phage antitermination protein Q YP_002403644.1 2691876 R 585055 CDS YP_002403645.1 218695978 7144809 complement(2692546..2692908) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; crossover junction endodeoxyribonuclease 2692908 rusA 7144809 rusA Escherichia coli 55989 crossover junction endodeoxyribonuclease YP_002403645.1 2692546 R 585055 CDS YP_002403646.1 218695979 7147560 complement(2692905..2693195) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2693195 7147560 EC55989_2627 Escherichia coli 55989 hypothetical protein YP_002403646.1 2692905 R 585055 CDS YP_002403647.1 218695980 7144810 complement(2693195..2693917) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA-binding protein from phage origin 2693917 roi 7144810 roi Escherichia coli 55989 DNA-binding protein from phage origin YP_002403647.1 2693195 R 585055 CDS YP_002403648.1 218695981 7147459 complement(2693910..2694080) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; phage protein 2694080 ninF 7147459 ninF Escherichia coli 55989 phage protein YP_002403648.1 2693910 R 585055 CDS YP_002403649.1 218695982 7147002 complement(2694256..2694666) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; ninB protein 2694666 7147002 EC55989_2630 Escherichia coli 55989 ninB protein YP_002403649.1 2694256 R 585055 CDS YP_002403650.1 218695983 7144811 complement(2694866..2695180) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 2695180 7144811 EC55989_2631 Escherichia coli 55989 phage protein YP_002403650.1 2694866 R 585055 CDS YP_002403651.1 218695984 7144812 complement(2695198..2695404) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 2695404 7144812 EC55989_2632 Escherichia coli 55989 phage protein YP_002403651.1 2695198 R 585055 CDS YP_002403652.1 218695985 7144813 complement(2695480..2696931) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; P protein; replicative DNA helicase 2696931 P 7144813 P Escherichia coli 55989 P protein; replicative DNA helicase YP_002403652.1 2695480 R 585055 CDS YP_002403653.1 218695986 7147092 complement(2696906..2697796) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; replication protein O 2697796 O 7147092 O Escherichia coli 55989 replication protein O YP_002403653.1 2696906 R 585055 CDS YP_002403654.1 218695987 7147062 complement(2697783..2697944) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2697944 7147062 EC55989_2635 Escherichia coli 55989 hypothetical protein YP_002403654.1 2697783 R 585055 CDS YP_002403655.1 218695988 7144814 complement(2697979..2698344) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Transcriptional activator protein C1 (modular protein) 2698344 C 7144814 C Escherichia coli 55989 Transcriptional activator protein C1 (modular protein) YP_002403655.1 2697979 R 585055 CDS YP_002403656.1 218695989 7145646 complement(2698366..2698551) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Regulatory protein cro (Antirepressor) 2698551 cro 7145646 cro Escherichia coli 55989 Regulatory protein cro (Antirepressor) YP_002403656.1 2698366 R 585055 CDS YP_002403657.1 218695990 7145759 2698632..2699282 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Repressor protein CII 2699282 cII 7145759 cII Escherichia coli 55989 Repressor protein CII YP_002403657.1 2698632 D 585055 CDS YP_002403658.1 218695991 7145707 complement(2699454..2699639) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2699639 7145707 EC55989_2639 Escherichia coli 55989 hypothetical protein YP_002403658.1 2699454 R 585055 CDS YP_002403659.1 218695992 7146940 2700362..2700832 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2700832 7146940 EC55989_2641 Escherichia coli 55989 hypothetical protein YP_002403659.1 2700362 D 585055 CDS YP_002403660.1 218695993 7144816 2700922..2701197 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2701197 7144816 EC55989_2642 Escherichia coli 55989 hypothetical protein YP_002403660.1 2700922 D 585055 CDS YP_002403661.1 218695994 7144817 2701164..2701364 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2701364 7144817 EC55989_2643 Escherichia coli 55989 hypothetical protein YP_002403661.1 2701164 D 585055 CDS YP_002403662.1 218695995 7144818 2701273..2701443 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2701443 7144818 EC55989_2644 Escherichia coli 55989 hypothetical protein YP_002403662.1 2701273 D 585055 CDS YP_002403663.1 218695996 7144819 2701424..2702059 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA single-strand annealing protein; essential recombination function protein Erf 2702059 erf 7144819 erf Escherichia coli 55989 DNA single-strand annealing protein; essential recombination function protein Erf YP_002403663.1 2701424 D 585055 CDS YP_002403664.1 218695997 7146021 2701969..2702442 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2702442 7146021 EC55989_2646 Escherichia coli 55989 hypothetical protein YP_002403664.1 2701969 D 585055 CDS YP_002403665.1 218695998 7144820 2702466..2702762 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Anti-RecBCD protein 2 2702762 abc 7144820 abc Escherichia coli 55989 Anti-RecBCD protein 2 YP_002403665.1 2702466 D 585055 CDS YP_002403666.1 218695999 7144821 2703224..2703895 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; EA22-like protein; similarities with EA22 from lambda (modular protein involved in blocking host replication) 2703895 7144821 EC55989_2649 Escherichia coli 55989 EA22-like protein; similarities with EA22 from lambda (modular protein involved in blocking host replication) YP_002403666.1 2703224 D 585055 CDS YP_002403667.1 218696000 7144822 2704068..2704256 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; prophage protein 2704256 7144822 EC55989_2650 Escherichia coli 55989 prophage protein YP_002403667.1 2704068 D 585055 CDS YP_002403668.1 218696001 7144823 2704258..2704467 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; prophage protein 2704467 7144823 EC55989_2651 Escherichia coli 55989 prophage protein YP_002403668.1 2704258 D 585055 CDS YP_002403669.1 218696002 7144824 2704464..2705093 1 NC_011748.1 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; prophage protein (fragment) 2705093 7144824 EC55989_2652 Escherichia coli 55989 prophage protein (fragment) YP_002403669.1 2704464 D 585055 CDS YP_002403670.1 218696003 7144825 2705501..2705701 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15197250; Product type r : regulator; response regulator inhibitor for tor operon 2705701 torI 7144825 torI Escherichia coli 55989 response regulator inhibitor for tor operon YP_002403670.1 2705501 D 585055 CDS YP_002403671.1 218696004 7147823 complement(2706231..2707478) 1 NC_011748.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease 2707478 lacY 7147823 lacY Escherichia coli 55989 galactoside permease YP_002403671.1 2706231 R 585055 CDS YP_002403672.1 218696005 7145764 complement(2707550..2708464) 1 NC_011748.1 phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase 2708464 cscK 7145764 cscK Escherichia coli 55989 aminoimidazole riboside kinase YP_002403672.1 2707550 R 585055 CDS YP_002403673.1 218696006 7145765 2708671..2710113 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12218016; Product type e : enzyme; sucrose-6-phosphate hydrolase 2710113 cscA 7145765 cscA Escherichia coli 55989 sucrose-6-phosphate hydrolase YP_002403673.1 2708671 D 585055 CDS YP_002403674.1 218696007 7145763 complement(2710121..2711302) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Sucrose operon repressor (Csc operon regulatory protein) 2711302 cscR 7145763 cscR Escherichia coli 55989 Sucrose operon repressor (Csc operon regulatory protein) YP_002403674.1 2710121 R 585055 CDS YP_002403675.1 218696008 7145955 2711583..2712911 1 NC_011748.1 catalyzes the formation of pyruvate from serine; D-serine dehydratase 2712911 dsdA 7145955 dsdA Escherichia coli 55989 D-serine dehydratase YP_002403675.1 2711583 D 585055 CDS YP_002403676.1 218696009 7145954 complement(2713019..2714557) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20378313; Product type pt : transporter; multidrug efflux system 2714557 emrY 7145954 emrY Escherichia coli 55989 multidrug efflux system YP_002403676.1 2713019 R 585055 CDS YP_002403677.1 218696010 7145995 complement(2714557..2715720) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20378313; Product type t : transporter; EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component 2715720 emrK 7145995 emrK Escherichia coli 55989 EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component YP_002403677.1 2714557 R 585055 CDS YP_002403678.1 218696011 7145994 2716136..2716750 1 NC_011748.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2716750 evgA 7145994 evgA Escherichia coli 55989 DNA-binding transcriptional activator EvgA YP_002403678.1 2716136 D 585055 CDS YP_002403679.1 218696012 7146038 2716755..2720348 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14523115, 93173621, 9501520, 10923791, 1289796, 8125343, 9535079; Product type r : regulator; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2720348 evgS 7146038 evgS Escherichia coli 55989 hybrid sensory histidine kinase in two-component regulatory system with EvgA YP_002403679.1 2716755 D 585055 CDS YP_002403680.1 218696013 7146039 complement(2720404..2721549) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 2721549 yfdE 7146039 yfdE Escherichia coli 55989 hypothetical protein YP_002403680.1 2720404 R 585055 CDS YP_002403681.1 218696014 7148724 complement(2721623..2722567) 1 NC_011748.1 member of the AEC family of auxin efflux transporters; unknown function; transporter YfdV 2722567 yfdV 7148724 yfdV Escherichia coli 55989 transporter YfdV YP_002403681.1 2721623 R 585055 CDS YP_002403682.1 218696015 7148726 complement(2722637..2724331) 1 NC_011748.1 catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase 2724331 oxc 7148726 oxc Escherichia coli 55989 oxalyl-CoA decarboxylase YP_002403682.1 2722637 R 585055 CDS YP_002403683.1 218696016 7147087 complement(2724385..2725635) 1 NC_011748.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase 2725635 frc 7147087 frc Escherichia coli 55989 formyl-coenzyme A transferase YP_002403683.1 2724385 R 585055 CDS YP_002403684.1 218696017 7146178 complement(2726148..2726780) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11157960; hypothetical protein 2726780 yfdX 7146178 yfdX Escherichia coli 55989 hypothetical protein YP_002403684.1 2726148 R 585055 CDS YP_002403685.1 218696018 7148727 2727076..2727351 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15183873; Product type lp : lipoprotein; lipoprotein 2727351 ypdI 7148727 ypdI Escherichia coli 55989 lipoprotein YP_002403685.1 2727076 D 585055 CDS YP_002403686.1 218696019 7149370 complement(2727428..2727670) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; Product type pm : membrane component; inner membrane protein 2727670 yfdY 7149370 yfdY Escherichia coli 55989 inner membrane protein YP_002403686.1 2727428 R 585055 CDS YP_002403688.1 218696021 7144826 2728023..2728943 1 NC_011748.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2728943 ddg 7144826 ddg Escherichia coli 55989 lipid A biosynthesis palmitoleoyl acyltransferase YP_002403688.1 2728023 D 585055 CDS YP_002403689.1 218696022 7147832 complement(2729435..2730673) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; aminotransferase 2730673 yfdZ 7147832 yfdZ Escherichia coli 55989 aminotransferase YP_002403689.1 2729435 R 585055 CDS YP_002403690.1 218696023 7148729 2731050..2732747 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type prc : receptor; sensory kinase in two-component system with YpdB 2732747 ypdA 7148729 ypdA Escherichia coli 55989 sensory kinase in two-component system with YpdB YP_002403690.1 2731050 D 585055 CDS YP_002403691.1 218696024 7149362 2732762..2733496 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type pr : regulator; response regulator in two-component system with YpdA 2733496 ypdB 7149362 ypdB Escherichia coli 55989 response regulator in two-component system with YpdA YP_002403691.1 2732762 D 585055 CDS YP_002403692.1 218696025 7149363 2733509..2734366 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding protein 2734366 ypdC 7149363 ypdC Escherichia coli 55989 DNA-binding protein YP_002403692.1 2733509 D 585055 CDS YP_002403693.1 218696026 7149364 complement(2734369..2736864) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; fused PTS enzymes (multiphosphoryl transfer protein): Hpr component ; enzyme I component ; enzyme IIA component 2736864 ypdD 7149364 ypdD Escherichia coli 55989 fused PTS enzymes (multiphosphoryl transfer protein): Hpr component ; enzyme I component ; enzyme IIA component YP_002403693.1 2734369 R 585055 CDS YP_002403694.1 218696027 7149365 complement(2736889..2737926) 1 NC_011748.1 metalloprotein; exoaminopeptidase 2737926 ypdE 7149365 ypdE Escherichia coli 55989 exoaminopeptidase YP_002403694.1 2736889 R 585055 CDS YP_002403695.1 218696028 7149366 complement(2737926..2739011) 1 NC_011748.1 Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase 2739011 ypdF 7149366 ypdF Escherichia coli 55989 aminopeptidase YP_002403695.1 2737926 R 585055 CDS YP_002403696.1 218696029 7149367 complement(2739026..2740273) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; enzyme IIC component of PTS 2740273 ypdG 7149367 ypdG Escherichia coli 55989 enzyme IIC component of PTS YP_002403696.1 2739026 R 585055 CDS YP_002403697.1 218696030 7149368 complement(2740295..2740621) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; enzyme IIB component of PTS 2740621 ypdH 7149368 ypdH Escherichia coli 55989 enzyme IIB component of PTS YP_002403697.1 2740295 R 585055 CDS YP_002403698.1 218696031 7149369 complement(2740840..2741805) 1 NC_011748.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase 2741805 glk 7149369 glk Escherichia coli 55989 glucokinase YP_002403698.1 2740840 R 585055 CDS YP_002403699.1 218696032 7146298 2742009..2743265 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; hypothetical protein 2743265 yfeO 7146298 yfeO Escherichia coli 55989 hypothetical protein YP_002403699.1 2742009 D 585055 CDS YP_002403700.1 218696033 7148737 2743380..2743706 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2743706 ypeC 7148737 ypeC Escherichia coli 55989 hypothetical protein YP_002403700.1 2743380 D 585055 CDS YP_002403701.1 218696034 7149373 complement(2743847..2745085) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20177822, 20305051, 10712688, 10844693; Product type t : transporter; manganese transport protein MntH 2745085 mntH 7149373 mntH Escherichia coli 55989 manganese transport protein MntH YP_002403701.1 2743847 R 585055 CDS YP_002403702.1 218696035 7146870 2745421..2746623 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 374403, 8022285, 7007808, 827549, 4563236, 1512211; Product type t : transporter; nucleoside (except guanosine) transporter 2746623 nupC 7146870 nupC Escherichia coli 55989 nucleoside (except guanosine) transporter YP_002403702.1 2745421 D 585055 CDS YP_002403703.1 218696036 7147056 complement(2746673..2748862) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; diguanylate cyclase 2748862 yfeA 7147056 yfeA Escherichia coli 55989 diguanylate cyclase YP_002403703.1 2746673 R 585055 CDS YP_002403704.1 218696037 7145388 2749496..2749840 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; nucleic acid-binding transcriptional regulator 2749840 yfeC 7145388 yfeC Escherichia coli 55989 nucleic acid-binding transcriptional regulator YP_002403704.1 2749496 D 585055 CDS YP_002403705.1 218696038 7148731 2749842..2750234 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; nucleic acid-binding transcriptional regulator 2750234 yfeD 7148731 yfeD Escherichia coli 55989 nucleic acid-binding transcriptional regulator YP_002403705.1 2749842 D 585055 CDS YP_002403706.1 218696039 7148732 complement(2750286..2751701) 1 NC_011748.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase 2751701 gltX 7148732 gltX Escherichia coli 55989 glutamyl-tRNA synthetase YP_002403706.1 2750286 R 585055 CDS YP_002403707.1 218696040 7145340 complement(2752622..2753506) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10400599, 7007808, 2201776, 7559336; Product type r : regulator; DNA-binding transcriptional activator XapR 2753506 xapR 7145340 xapR Escherichia coli 55989 DNA-binding transcriptional activator XapR YP_002403707.1 2752622 R 585055 CDS YP_002403708.1 218696041 7147984 complement(2753758..2755014) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96032385, 7559336; Product type t : transporter; xanthosine transporter 2755014 xapB 7147984 xapB Escherichia coli 55989 xanthosine transporter YP_002403708.1 2753758 R 585055 CDS YP_002403709.1 218696042 7147983 complement(2755074..2755907) 1 NC_011748.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase 2755907 xapA 7147983 xapA Escherichia coli 55989 purine nucleoside phosphorylase YP_002403709.1 2755074 R 585055 CDS YP_002403710.1 218696043 7147982 2756156..2756920 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; hypothetical protein 2756920 yfeN 7147982 yfeN Escherichia coli 55989 hypothetical protein YP_002403710.1 2756156 D 585055 CDS YP_002403711.1 218696044 7148736 complement(2756959..2757885) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 2757885 yfeR 7148736 yfeR Escherichia coli 55989 DNA-binding transcriptional regulator YP_002403711.1 2756959 R 585055 CDS YP_002403712.1 218696045 7148738 2757975..2758973 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; sodium/bile acid symporter family (mazG-like) 2758973 yfeH 7148738 yfeH Escherichia coli 55989 sodium/bile acid symporter family (mazG-like) YP_002403712.1 2757975 D 585055 CDS YP_002403713.1 218696046 7148734 complement(2758970..2759188) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2759188 ypeB 7148734 ypeB Escherichia coli 55989 hypothetical protein YP_002403713.1 2758970 R 585055 CDS YP_002403714.1 218696047 7149372 complement(2759190..2761205) 1 NC_011748.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA 2761205 ligA 7149372 ligA Escherichia coli 55989 NAD-dependent DNA ligase LigA YP_002403714.1 2759190 R 585055 CDS YP_002403715.1 218696048 7146700 complement(2761276..2762262) 1 NC_011748.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA 2762262 zipA 7146700 zipA Escherichia coli 55989 cell division protein ZipA YP_002403715.1 2761276 R 585055 CDS YP_002403716.1 218696049 7149488 2762492..2763253 1 NC_011748.1 role in sulfur assimilation; sulfate transport protein CysZ 2763253 cysZ 7149488 cysZ Escherichia coli 55989 sulfate transport protein CysZ YP_002403716.1 2762492 D 585055 CDS YP_002403717.1 218696050 7145837 2763438..2764409 1 NC_011748.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2764409 cysK 7145837 cysK Escherichia coli 55989 cysteine synthase A YP_002403717.1 2763438 D 585055 CDS YP_002403718.1 218696051 7145829 2764793..2765050 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type t : transporter; PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr 2765050 ptsH 7145829 ptsH Escherichia coli 55989 PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr YP_002403718.1 2764793 D 585055 CDS YP_002403719.1 218696052 7147288 2765095..2766822 1 NC_011748.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2766822 ptsI 7147288 ptsI Escherichia coli 55989 phosphoenolpyruvate-protein phosphotransferase YP_002403719.1 2765095 D 585055 CDS YP_002403720.1 218696053 7147289 2766863..2767372 1 NC_011748.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter 2767372 crr 7147289 crr Escherichia coli 55989 PTS system glucose-specific transporter YP_002403720.1 2766863 D 585055 CDS YP_002403721.1 218696054 7145762 complement(2767414..2768265) 1 NC_011748.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase 2768265 pdxK 7145762 pdxK Escherichia coli 55989 pyridoxal kinase YP_002403721.1 2767414 R 585055 CDS YP_002403722.1 218696055 7147128 2768370..2768738 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2768738 yfeK 7147128 yfeK Escherichia coli 55989 hypothetical protein YP_002403722.1 2768370 D 585055 CDS YP_002403723.1 218696056 7148735 complement(2768741..2769652) 1 NC_011748.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B 2769652 cysM 7148735 cysM Escherichia coli 55989 cysteine synthase B YP_002403723.1 2768741 R 585055 CDS YP_002403724.1 218696057 7145830 complement(2769786..2770883) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 90264334, 2188958, 7665461; Product type t : transporter; sulfate/thiosulfate transporter subunit 2770883 cysA 7145830 cysA Escherichia coli 55989 sulfate/thiosulfate transporter subunit YP_002403724.1 2769786 R 585055 CDS YP_002403725.1 218696058 7145820 complement(2770873..2771748) 1 NC_011748.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit 2771748 cysW 7145820 cysW Escherichia coli 55989 sulfate/thiosulfate transporter permease subunit YP_002403725.1 2770873 R 585055 CDS YP_002403726.1 218696059 7145836 complement(2771748..2772581) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264334, 2188958; Product type t : transporter; sulfate/thiosulfate transporter subunit 2772581 cysU 7145836 cysU Escherichia coli 55989 sulfate/thiosulfate transporter subunit YP_002403726.1 2771748 R 585055 CDS YP_002403727.1 218696060 7145835 complement(2772581..2773597) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264335, 2188959, 9298646; Product type t : transporter; thiosulfate transporter subunit 2773597 cysP 7145835 cysP Escherichia coli 55989 thiosulfate transporter subunit YP_002403727.1 2772581 R 585055 CDS YP_002403728.1 218696061 7145832 complement(2773768..2774559) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 97385354, 2188959, 7984428, 9241368; Product type pe : enzyme; short chain dehydrogenase 2774559 ucpA 7145832 ucpA Escherichia coli 55989 short chain dehydrogenase YP_002403728.1 2773768 R 585055 CDS YP_002403729.1 218696062 7147896 complement(2774688..2775545) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 2775545 yfeT 7147896 yfeT Escherichia coli 55989 DNA-binding transcriptional regulator YP_002403729.1 2774688 R 585055 CDS YP_002403730.1 218696063 7148739 2775709..2776605 1 NC_011748.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 2776605 murQ 7148739 murQ Escherichia coli 55989 N-acetylmuramic acid 6-phosphate etherase YP_002403730.1 2775709 D 585055 CDS YP_002403731.1 218696064 7148740 2776609..2778033 1 NC_011748.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunit IIBC 2778033 murP 7148740 murP Escherichia coli 55989 PTS system N-acetylmuramic acid transporter subunit IIBC YP_002403731.1 2776609 D 585055 CDS YP_002403732.1 218696065 7146929 2778038..2779342 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15983044, 15060041; Product type e : enzyme; hypothetical protein 2779342 murQ 7146929 murQ Escherichia coli 55989 hypothetical protein YP_002403732.1 2778038 D 585055 CDS YP_002403733.1 218696066 7146930 complement(2779398..2780297) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2780297 yfeX 7146930 yfeX Escherichia coli 55989 hypothetical protein YP_002403733.1 2779398 R 585055 CDS YP_002403734.1 218696067 7148741 complement(2780393..2780968) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12900013, 7764507; hypothetical protein 2780968 yfeY 7148741 yfeY Escherichia coli 55989 hypothetical protein YP_002403734.1 2780393 R 585055 CDS YP_002403735.1 218696068 7148742 complement(2781029..2781478) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2781478 yfeZ 7148742 yfeZ Escherichia coli 55989 inner membrane protein YP_002403735.1 2781029 R 585055 CDS YP_002403736.1 218696069 7148743 complement(2781465..2781890) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acetyltransferase 2781890 ypeA 7148743 ypeA Escherichia coli 55989 acetyltransferase YP_002403736.1 2781465 R 585055 CDS YP_002403737.1 218696070 7149371 2782104..2782973 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 6137479, 87242501, 1903834, 8300522; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase I 2782973 amiA 7149371 amiA Escherichia coli 55989 N-acetylmuramoyl-l-alanine amidase I YP_002403737.1 2782104 D 585055 CDS YP_002403738.1 218696071 7145490 2782977..2783876 1 NC_011748.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2783876 hemF 7145490 hemF Escherichia coli 55989 coproporphyrinogen III oxidase YP_002403738.1 2782977 D 585055 CDS YP_002403739.1 218696072 7146412 complement(2783882..2784934) 1 NC_011748.1 activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR 2784934 yfeG 7146412 yfeG Escherichia coli 55989 transcriptional regulator EutR YP_002403739.1 2783882 R 585055 CDS YP_002403740.1 218696073 7148733 complement(2784980..2785480) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10464203; Product type ps : structure; ethanolaminosome structural protein with role in ethanolamine utilization 2785480 yffI 7148733 yffI Escherichia coli 55989 ethanolaminosome structural protein with role in ethanolamine utilization YP_002403740.1 2784980 R 585055 CDS YP_002403741.1 218696074 7148746 complement(2785493..2786152) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : structure; carboxysome-related structural protein with role in ethanolamine utilization 2786152 eutL 7148746 eutL Escherichia coli 55989 carboxysome-related structural protein with role in ethanolamine utilization YP_002403741.1 2785493 R 585055 CDS YP_002403742.1 218696075 7146034 complement(2786162..2787049) 1 NC_011748.1 catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit 2787049 eutC 7146034 eutC Escherichia coli 55989 ethanolamine ammonia-lyase small subunit YP_002403742.1 2786162 R 585055 CDS YP_002403743.1 218696076 7146028 complement(2787070..2788431) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3905806, 10464203; Product type e : enzyme; ethanolamine ammonia-lyase, large subunit, heavy chain 2788431 eutB 7146028 eutB Escherichia coli 55989 ethanolamine ammonia-lyase, large subunit, heavy chain YP_002403743.1 2787070 R 585055 CDS YP_002403744.1 218696077 7146027 complement(2788443..2789846) 1 NC_011748.1 ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase 2789846 eutA 7146027 eutA Escherichia coli 55989 reactivating factor for ethanolamine ammonia lyase YP_002403744.1 2788443 R 585055 CDS YP_002403745.1 218696078 7146026 complement(2789843..2791069) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7868611, 10464203; Product type pt : transporter; ethanolamine transporter 2791069 eutH 7146026 eutH Escherichia coli 55989 ethanolamine transporter YP_002403745.1 2789843 R 585055 CDS YP_002403746.1 218696079 7146031 complement(2791386..2792573) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : enzyme; alcohol dehydrogenase in ethanolamine utilization; ethanolaminosome 2792573 eutG 7146031 eutG Escherichia coli 55989 alcohol dehydrogenase in ethanolamine utilization; ethanolaminosome YP_002403746.1 2791386 R 585055 CDS YP_002403747.1 218696080 7146030 complement(2792563..2793399) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pf : factor; chaperonin, ethanolamine utilization protein 2793399 eutJ 7146030 eutJ Escherichia coli 55989 chaperonin, ethanolamine utilization protein YP_002403747.1 2792563 R 585055 CDS YP_002403748.1 218696081 7146033 complement(2793410..2794813) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : enzyme; aldehyde dehydrogenase, ethanolamine utilization protein 2794813 eutE 7146033 eutE Escherichia coli 55989 aldehyde dehydrogenase, ethanolamine utilization protein YP_002403748.1 2793410 R 585055 CDS YP_002403749.1 218696082 7146029 complement(2794825..2795112) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : structure; carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein 2795112 cchB 7146029 cchB Escherichia coli 55989 carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein YP_002403749.1 2794825 R 585055 CDS YP_002403750.1 218696083 7145673 complement(2795219..2795512) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : structure; carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein 2795512 cchA 7145673 cchA Escherichia coli 55989 carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein YP_002403750.1 2795219 R 585055 CDS YP_002403751.1 218696084 7145672 complement(2795551..2796567) 1 NC_011748.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase 2796567 eutD 7145672 eutD Escherichia coli 55989 phosphotransacetylase YP_002403751.1 2795551 R 585055 CDS YP_002403752.1 218696085 7146032 complement(2796564..2797367) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : enzyme; cobalamin adenosyltransferase in ethanolamine utilization 2797367 eutT 7146032 eutT Escherichia coli 55989 cobalamin adenosyltransferase in ethanolamine utilization YP_002403752.1 2796564 R 585055 CDS YP_002403753.1 218696086 7146037 complement(2797364..2798065) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10464203; hypothetical protein 2798065 eutQ 7146037 eutQ Escherichia coli 55989 hypothetical protein YP_002403753.1 2797364 R 585055 CDS YP_002403754.1 218696087 7146036 complement(2798040..2798519) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : enzyme; nucleoside triphosphate hydrolase domain protein 2798519 eutP 7146036 eutP Escherichia coli 55989 nucleoside triphosphate hydrolase domain protein YP_002403754.1 2798040 R 585055 CDS YP_002403755.1 218696088 7146035 complement(2798532..2798867) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : structure; carboxysome-like ethanolaminosome structural protein with role in ethanol utilization 2798867 ypfE 7146035 ypfE Escherichia coli 55989 carboxysome-like ethanolaminosome structural protein with role in ethanol utilization YP_002403755.1 2798532 R 585055 CDS YP_002403756.1 218696089 7149374 complement(2799160..2801439) 1 NC_011748.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme 2801439 maeB 7149374 maeB Escherichia coli 55989 malic enzyme YP_002403756.1 2799160 R 585055 CDS YP_002403757.1 218696090 7146766 2801728..2802678 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90230300; Product type e : enzyme; transaldolase A 2802678 talA 7146766 talA Escherichia coli 55989 transaldolase A YP_002403757.1 2801728 D 585055 CDS YP_002403758.1 218696091 7147747 2802698..2804701 1 NC_011748.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2804701 tktB 7147747 tktB Escherichia coli 55989 transketolase YP_002403758.1 2802698 D 585055 CDS YP_002403759.1 218696092 7147805 complement(2804797..2805840) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2805840 ypfG 7147805 ypfG Escherichia coli 55989 hypothetical protein YP_002403759.1 2804797 R 585055 CDS YP_002403760.1 218696093 7149375 complement(2805966..2806541) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; NUDIX hydrolase 2806541 yffH 7149375 yffH Escherichia coli 55989 NUDIX hydrolase YP_002403760.1 2805966 R 585055 CDS YP_002403761.1 218696094 7148745 complement(2806609..2808588) 1 NC_011748.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit 2808588 aegA 7148745 aegA Escherichia coli 55989 oxidoreductase Fe-S binding subunit YP_002403761.1 2806609 R 585055 CDS YP_002403762.1 218696095 7145462 2808794..2810494 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92374842, 1508040, 1528845; Product type r : regulator; nitrate/nitrite sensor protein NarQ 2810494 narQ 7145462 narQ Escherichia coli 55989 nitrate/nitrite sensor protein NarQ YP_002403762.1 2808794 D 585055 CDS YP_002403763.1 218696096 7146974 2810658..2813771 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12426336, 20158894, 21450803, 79216220, 10692383, 1644752; Product type t : transporter; aminoglycoside/multidrug efflux system 2813771 acrD 7146974 acrD Escherichia coli 55989 aminoglycoside/multidrug efflux system YP_002403763.1 2810658 D 585055 CDS YP_002403764.1 218696097 7145446 2814310..2814666 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2814666 yffB 7145446 yffB Escherichia coli 55989 hypothetical protein YP_002403764.1 2814310 D 585055 CDS YP_002403765.1 218696098 7148744 2814670..2815797 1 NC_011748.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2815797 dapE 7148744 dapE Escherichia coli 55989 succinyl-diaminopimelate desuccinylase YP_002403765.1 2814670 D 585055 CDS YP_002403766.1 218696099 7145852 2815825..2816025 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2816025 ypfN 7145852 ypfN Escherichia coli 55989 hypothetical protein YP_002403766.1 2815825 D 585055 CDS YP_002403767.1 218696100 7149379 complement(2816135..2816833) 1 NC_011748.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YpfH 2816833 ypfH 7149379 ypfH Escherichia coli 55989 esterase YpfH YP_002403767.1 2816135 R 585055 CDS YP_002403768.1 218696101 7149376 complement(2816907..2818922) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase 2818922 ypfI 7149376 ypfI Escherichia coli 55989 hydrolase YP_002403768.1 2816907 R 585055 CDS YP_002403769.1 218696102 7149377 complement(2818937..2819800) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2819800 ypfJ 7149377 ypfJ Escherichia coli 55989 hypothetical protein YP_002403769.1 2818937 R 585055 CDS YP_002403770.1 218696103 7149378 complement(2819947..2820345) 1 NC_011748.1 stability determinant protein; plasmid maintenance protein 2820345 7149378 EC55989_2757 Escherichia coli 55989 plasmid maintenance protein YP_002403770.1 2819947 R 585055 CDS YP_002403771.1 218696104 7144827 complement(2820345..2820611) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; transcriptionnal regulation protein 2820611 7144827 EC55989_2758 Escherichia coli 55989 transcriptionnal regulation protein YP_002403771.1 2820345 R 585055 CDS YP_002403772.1 218696105 7144828 complement(2820727..2821440) 1 NC_011748.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase 2821440 purC 7144828 purC Escherichia coli 55989 phosphoribosylaminoimidazole-succinocarboxamide synthase YP_002403772.1 2820727 R 585055 CDS YP_002403773.1 218696106 7147294 complement(2821653..2822687) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358331, 1885529, 2120198; Product type lp : lipoprotein; lipoprotein 2822687 nlpB 7147294 nlpB Escherichia coli 55989 lipoprotein YP_002403773.1 2821653 R 585055 CDS YP_002403774.1 218696107 7147007 complement(2822704..2823582) 1 NC_011748.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase 2823582 dapA 7147007 dapA Escherichia coli 55989 dihydrodipicolinate synthase YP_002403774.1 2822704 R 585055 CDS YP_002403775.1 218696108 7145849 2823728..2824300 1 NC_011748.1 negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2824300 gcvR 7145849 gcvR Escherichia coli 55989 glycine cleavage system transcriptional repressor YP_002403775.1 2823728 D 585055 CDS YP_002403776.1 218696109 7146278 2824300..2824770 1 NC_011748.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2824770 bcp 7146278 bcp Escherichia coli 55989 thioredoxin-dependent thiol peroxidase YP_002403776.1 2824300 D 585055 CDS YP_002403777.1 218696110 7145600 2825023..2825640 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241, 2016588; Product type c : carrier; hydrogenase 4, 4Fe-4S subunit 2825640 hyfA 7145600 hyfA Escherichia coli 55989 hydrogenase 4, 4Fe-4S subunit YP_002403777.1 2825023 D 585055 CDS YP_002403778.1 218696111 7146506 2825640..2827658 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit B 2827658 hyfB 7146506 hyfB Escherichia coli 55989 hydrogenase 4 subunit B YP_002403778.1 2825640 D 585055 CDS YP_002403779.1 218696112 7146511 2830083..2830733 1 NC_011748.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2830733 hyfE 7146511 hyfE Escherichia coli 55989 hydrogenase 4 membrane subunit YP_002403779.1 2830083 D 585055 CDS YP_002403780.1 218696113 7146512 2830738..2832318 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit F 2832318 hyfF 7146512 hyfF Escherichia coli 55989 hydrogenase 4 subunit F YP_002403780.1 2830738 D 585055 CDS YP_002403781.1 218696114 7146513 2832356..2834023 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type c : carrier; hydrogenase 4 subunit 2834023 hyfG 7146513 hyfG Escherichia coli 55989 hydrogenase 4 subunit YP_002403781.1 2832356 D 585055 CDS YP_002403782.1 218696115 7146514 2834033..2834572 1 NC_011748.1 probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 2834572 hyfH 7146514 hyfH Escherichia coli 55989 hydrogenase 4 subunit H YP_002403782.1 2834033 D 585055 CDS YP_002403783.1 218696116 7146515 2834569..2835327 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type c : carrier; hydrogenase 4, Fe-S subunit 2835327 hyfI 7146515 hyfI Escherichia coli 55989 hydrogenase 4, Fe-S subunit YP_002403783.1 2834569 D 585055 CDS YP_002403784.1 218696117 7146516 2835320..2835733 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9387241; Product type pf : factor; processing element hydrogenase 4 2835733 hyfJ 7146516 hyfJ Escherichia coli 55989 processing element hydrogenase 4 YP_002403784.1 2835320 D 585055 CDS YP_002403785.1 218696118 7146517 2835763..2837775 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type r : regulator; DNA-binding transcriptional activator, formate sensing 2837775 hyfR 7146517 hyfR Escherichia coli 55989 DNA-binding transcriptional activator, formate sensing YP_002403785.1 2835763 D 585055 CDS YP_002403786.1 218696119 7146518 2837797..2838528 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9387241; Product type pt : transporter; formate transporter 2838528 focB 7146518 focB Escherichia coli 55989 formate transporter YP_002403786.1 2837797 D 585055 CDS YP_002403787.1 218696120 7146167 complement(2838682..2839743) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; permease 2839743 perM 7146167 perM Escherichia coli 55989 permease YP_002403787.1 2838682 R 585055 CDS YP_002403788.1 218696121 7147138 2839956..2841419 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; peptidase 2841419 yfgC 7147138 yfgC Escherichia coli 55989 peptidase YP_002403788.1 2839956 D 585055 CDS YP_002403789.1 218696122 7148749 2841440..2841799 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase 2841799 yfgD 7148749 yfgD Escherichia coli 55989 oxidoreductase YP_002403789.1 2841440 D 585055 CDS YP_002403790.1 218696123 7148750 complement(2841937..2842683) 1 NC_011748.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor 2842683 hda 7148750 hda Escherichia coli 55989 DNA replication initiation factor YP_002403790.1 2841937 R 585055 CDS YP_002403791.1 218696124 7146400 complement(2842733..2844022) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 7721693; Product type t : transporter; uracil transporter 2844022 uraA 7146400 uraA Escherichia coli 55989 uracil transporter YP_002403791.1 2842733 R 585055 CDS YP_002403792.1 218696125 7147925 complement(2844108..2844734) 1 NC_011748.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase 2844734 upp 7147925 upp Escherichia coli 55989 uracil phosphoribosyltransferase YP_002403792.1 2844108 R 585055 CDS YP_002403793.1 218696126 7147924 2845059..2846096 1 NC_011748.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2846096 purM 7147924 purM Escherichia coli 55989 phosphoribosylaminoimidazole synthetase YP_002403793.1 2845059 D 585055 CDS YP_002403794.1 218696127 7147301 2846096..2846734 1 NC_011748.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2846734 purN 7147301 purN Escherichia coli 55989 phosphoribosylglycinamide formyltransferase YP_002403794.1 2846096 D 585055 CDS YP_002403795.1 218696128 7147302 2846905..2848971 1 NC_011748.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2848971 ppk 7147302 ppk Escherichia coli 55989 polyphosphate kinase YP_002403795.1 2846905 D 585055 CDS YP_002403796.1 218696129 7147232 2848976..2850517 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93107072, 94025037, 94165003, 8212131, 8380170; Product type e : enzyme; exopolyphosphatase 2850517 ppx 7147232 ppx Escherichia coli 55989 exopolyphosphatase YP_002403796.1 2848976 D 585055 CDS YP_002403797.1 218696130 7147235 complement(2850556..2852799) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2852799 yfgF 7147235 yfgF Escherichia coli 55989 inner membrane protein YP_002403797.1 2850556 R 585055 CDS YP_002403798.1 218696131 7148751 complement(2853016..2853306) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 2853306 7148751 EC55989_2789 Escherichia coli 55989 hypothetical protein YP_002403798.1 2853016 R 585055 CDS YP_002403799.1 218696132 7144829 2853653..2854171 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; outer membrane lipoprotein 2854171 yfgH 7144829 yfgH Escherichia coli 55989 outer membrane lipoprotein YP_002403799.1 2853653 D 585055 CDS YP_002403800.1 218696133 7148752 2854187..2854726 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2854726 yfgI 7148752 yfgI Escherichia coli 55989 hypothetical protein YP_002403800.1 2854187 D 585055 CDS YP_002403801.1 218696134 7148753 complement(2854819..2856396) 1 NC_011748.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase 2856396 guaA 7148753 guaA Escherichia coli 55989 GMP synthase YP_002403801.1 2854819 R 585055 CDS YP_002403802.1 218696135 7146378 complement(2856465..2857931) 1 NC_011748.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase 2857931 guaB 7146378 guaB Escherichia coli 55989 inosine 5'-monophosphate dehydrogenase YP_002403802.1 2856465 R 585055 CDS YP_002403803.1 218696136 7146379 2858093..2859463 1 NC_011748.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2859463 xseA 7146379 xseA Escherichia coli 55989 exodeoxyribonuclease VII large subunit YP_002403803.1 2858093 D 585055 CDS YP_002403804.1 218696137 7147992 complement(2859460..2859675) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2859675 yfgJ 7147992 yfgJ Escherichia coli 55989 hypothetical protein YP_002403804.1 2859460 R 585055 CDS YP_002403805.1 218696138 7148754 complement(2859744..2861216) 1 NC_011748.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA 2861216 engA 7148754 engA Escherichia coli 55989 GTP-binding protein EngA YP_002403805.1 2859744 R 585055 CDS YP_002403806.1 218696139 7145892 complement(2861334..2862512) 1 NC_011748.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL 2862512 yfgL 7145892 yfgL Escherichia coli 55989 outer membrane protein assembly complex subunit YfgL YP_002403806.1 2861334 R 585055 CDS YP_002403807.1 218696140 7148755 complement(2862523..2863143) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2863143 yfgM 7148755 yfgM Escherichia coli 55989 hypothetical protein YP_002403807.1 2862523 R 585055 CDS YP_002403808.1 218696141 7148756 complement(2863161..2864435) 1 NC_011748.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase 2864435 hisS 7148756 hisS Escherichia coli 55989 histidyl-tRNA synthetase YP_002403808.1 2863161 R 585055 CDS YP_002403809.1 218696142 7145309 complement(2864546..2865664) 1 NC_011748.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase 2865664 ispG 7145309 ispG Escherichia coli 55989 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase YP_002403809.1 2864546 R 585055 CDS YP_002403810.1 218696143 7146630 complement(2865691..2866704) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; cytoskeletal protein RodZ 2866704 yfgA 7146630 yfgA Escherichia coli 55989 cytoskeletal protein RodZ YP_002403810.1 2865691 R 585055 CDS YP_002403811.1 218696144 7148747 complement(2866989..2868143) 1 NC_011748.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N 2868143 yfgB 7148747 yfgB Escherichia coli 55989 ribosomal RNA large subunit methyltransferase N YP_002403811.1 2866989 R 585055 CDS YP_002403812.1 218696145 7148748 complement(2868293..2868724) 1 NC_011748.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase 2868724 ndk 7148748 ndk Escherichia coli 55989 nucleoside diphosphate kinase YP_002403812.1 2868293 R 585055 CDS YP_002403813.1 218696146 7146982 complement(2868873..2871185) 1 NC_011748.1 penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C 2871185 pbpC 7146982 pbpC Escherichia coli 55989 penicillin-binding protein 1C YP_002403813.1 2868873 R 585055 CDS YP_002403814.1 218696147 7147118 complement(2871186..2876147) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2876147 yfhM 7147118 yfhM Escherichia coli 55989 hypothetical protein YP_002403814.1 2871186 R 585055 CDS YP_002403815.1 218696148 7148765 2876354..2877199 1 NC_011748.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2877199 sseA 7148765 sseA Escherichia coli 55989 3-mercaptopyruvate sulfurtransferase YP_002403815.1 2876354 D 585055 CDS YP_002403816.1 218696149 7147581 complement(2877692..2878468) 1 NC_011748.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB 2878468 sseB 7147581 sseB Escherichia coli 55989 enhanced serine sensitivity protein SseB YP_002403816.1 2877692 R 585055 CDS YP_002403817.1 218696150 7147712 complement(2878610..2879893) 1 NC_011748.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase 2879893 pepB 7147712 pepB Escherichia coli 55989 aminopeptidase YP_002403817.1 2878610 R 585055 CDS YP_002403818.1 218696151 7147131 complement(2880071..2880271) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10393315; Product type pf : factor; hypothetical protein 2880271 yfhJ 7147131 yfhJ Escherichia coli 55989 hypothetical protein YP_002403818.1 2880071 R 585055 CDS YP_002403819.1 218696152 7148762 complement(2880283..2880618) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 20013001, 92283811, 94181532, 11551196, 1317854, 4375562, 8300516; Product type c : carrier; [2Fe-2S] ferredoxin 2880618 fdx 7148762 fdx Escherichia coli 55989 [2Fe-2S] ferredoxin YP_002403819.1 2880283 R 585055 CDS YP_002403820.1 218696153 7146076 complement(2880620..2882470) 1 NC_011748.1 involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA 2882470 hscA 7146076 hscA Escherichia coli 55989 chaperone protein HscA YP_002403820.1 2880620 R 585055 CDS YP_002403821.1 218696154 7146461 complement(2882487..2883002) 1 NC_011748.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB 2883002 hscB 7146461 hscB Escherichia coli 55989 co-chaperone HscB YP_002403821.1 2882487 R 585055 CDS YP_002403822.1 218696155 7146462 complement(2883098..2883421) 1 NC_011748.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein 2883421 iscA 7146462 iscA Escherichia coli 55989 iron-sulfur cluster assembly protein YP_002403822.1 2883098 R 585055 CDS YP_002403823.1 218696156 7146620 complement(2883438..2883824) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 11994302, 15153099; Product type f : factor; scaffold protein 2883824 iscU 7146620 iscU Escherichia coli 55989 scaffold protein YP_002403823.1 2883438 R 585055 CDS YP_002403824.1 218696157 7146623 complement(2883852..2885066) 1 NC_011748.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase 2885066 iscS 7146623 iscS Escherichia coli 55989 cysteine desulfurase YP_002403824.1 2883852 R 585055 CDS YP_002403825.1 218696158 7146622 complement(2885178..2885666) 1 NC_011748.1 regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR 2885666 iscR 7146622 iscR Escherichia coli 55989 DNA-binding transcriptional regulator IscR YP_002403825.1 2885178 R 585055 CDS YP_002403826.1 218696159 7146621 complement(2885936..2886676) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10393315; Product type pe : enzyme; methyltransferase 2886676 yfhQ 7146621 yfhQ Escherichia coli 55989 methyltransferase YP_002403826.1 2885936 R 585055 CDS YP_002403827.1 218696160 7148766 2886795..2887598 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6389495, 90202735, 95095968, 10747806, 2138605, 8002619; Product type e : enzyme; inositol monophosphatase 2887598 suhB 7148766 suhB Escherichia coli 55989 inositol monophosphatase YP_002403827.1 2886795 D 585055 CDS YP_002403828.1 218696161 7147738 2887716..2888597 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; peptidase 2888597 yfhR 7147738 yfhR Escherichia coli 55989 peptidase YP_002403828.1 2887716 D 585055 CDS YP_002403829.1 218696162 7148767 2888788..2890068 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95020540, 96154950; Product type cp : cell process; stationary phase inducible protein CsiE 2890068 csiE 7148767 csiE Escherichia coli 55989 stationary phase inducible protein CsiE YP_002403829.1 2888788 D 585055 CDS YP_002403830.1 218696163 7145775 complement(2890060..2891199) 1 NC_011748.1 transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter 2891199 hcaT 7145775 hcaT Escherichia coli 55989 3-phenylpropionic acid transporter YP_002403830.1 2890060 R 585055 CDS YP_002403831.1 218696164 7146396 complement(2891359..2892249) 1 NC_011748.1 activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR 2892249 hcaR 7146396 hcaR Escherichia coli 55989 DNA-binding transcriptional regulator HcaR YP_002403831.1 2891359 R 585055 CDS YP_002403832.1 218696165 7146395 2892385..2893746 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83238171, 87008429, 98269008; Product type e : enzyme; 3-phenylpropionate dioxygenase, large (alpha) subunit 2893746 hcaE 7146395 hcaE Escherichia coli 55989 3-phenylpropionate dioxygenase, large (alpha) subunit YP_002403832.1 2892385 D 585055 CDS YP_002403833.1 218696166 7146393 2893743..2894261 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83238171, 87008429, 98269008, 9603882; Product type e : enzyme; 3-phenylpropionate dioxygenase subunit beta 2894261 hcaF 7146393 hcaF Escherichia coli 55989 3-phenylpropionate dioxygenase subunit beta YP_002403833.1 2893743 D 585055 CDS YP_002403834.1 218696167 7146394 2894261..2894581 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98269008, 9603882; Product type pc : carrier; 3-phenylpropionate dioxygenase ferredoxin subunit 2894581 hcaC 7146394 hcaC Escherichia coli 55989 3-phenylpropionate dioxygenase ferredoxin subunit YP_002403834.1 2894261 D 585055 CDS YP_002403835.1 218696168 7146391 2894578..2895390 1 NC_011748.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 2895390 hcaB 7146391 hcaB Escherichia coli 55989 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase YP_002403835.1 2894578 D 585055 CDS YP_002403836.1 218696169 7146390 2895400..2896602 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98269008, 9603882; Product type e : enzyme; phenylpropionate dioxygenase ferredoxin reductase subunit 2896602 hcaD 7146390 hcaD Escherichia coli 55989 phenylpropionate dioxygenase ferredoxin reductase subunit YP_002403836.1 2895400 D 585055 CDS YP_002403837.1 218696170 7146392 2896699..2897121 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2897121 yphA 7146392 yphA Escherichia coli 55989 inner membrane protein YP_002403837.1 2896699 D 585055 CDS YP_002403838.1 218696171 7149380 complement(2897169..2898041) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2898041 yphB 7149380 yphB Escherichia coli 55989 hypothetical protein YP_002403838.1 2897169 R 585055 CDS YP_002403839.1 218696172 7149381 complement(2898053..2899114) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase, Zn-dependent and NAD(P)-binding 2899114 yphC 7149381 yphC Escherichia coli 55989 oxidoreductase, Zn-dependent and NAD(P)-binding YP_002403839.1 2898053 R 585055 CDS YP_002403840.1 218696173 7149382 complement(2899180..2900178) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sugar transporter subunit: membrane component of ABC superfamily 2900178 yphD 7149382 yphD Escherichia coli 55989 sugar transporter subunit: membrane component of ABC superfamily YP_002403840.1 2899180 R 585055 CDS YP_002403841.1 218696174 7149383 complement(2900203..2901714) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; fused sugar transporter subunits of ABC superfamily: ATP-binding components 2901714 yphE 7149383 yphE Escherichia coli 55989 fused sugar transporter subunits of ABC superfamily: ATP-binding components YP_002403841.1 2900203 R 585055 CDS YP_002403842.1 218696175 7149384 complement(2901737..2902720) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : transporter; sugar transporter subunit: periplasmic-binding component of ABC superfamily 2902720 yphF 7149384 yphF Escherichia coli 55989 sugar transporter subunit: periplasmic-binding component of ABC superfamily YP_002403842.1 2901737 R 585055 CDS YP_002403843.1 218696176 7149385 complement(2902817..2906098) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2906098 yphG 7149385 yphG Escherichia coli 55989 hypothetical protein YP_002403843.1 2902817 R 585055 CDS YP_002403844.1 218696177 7149386 2906216..2907409 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 2907409 yphH 7149386 yphH Escherichia coli 55989 DNA-binding transcriptional regulator YP_002403844.1 2906216 D 585055 CDS YP_002403845.1 218696178 7149387 complement(2907473..2908726) 1 NC_011748.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase 2908726 glyA 7149387 glyA Escherichia coli 55989 serine hydroxymethyltransferase YP_002403845.1 2907473 R 585055 CDS YP_002403846.1 218696179 7146339 2909054..2910244 1 NC_011748.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2910244 hmp 7146339 hmp Escherichia coli 55989 nitric oxide dioxygenase YP_002403846.1 2909054 D 585055 CDS YP_002403847.1 218696180 7146447 complement(2910289..2910627) 1 NC_011748.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 2910627 glnB 7146447 glnB Escherichia coli 55989 nitrogen regulatory protein P-II 1 YP_002403847.1 2910289 R 585055 CDS YP_002403848.1 218696181 7146303 complement(2910688..2912022) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8226691, 8412694; Product type pr : regulator; two component system DNA-binding response regulator 2912022 yfhA 7146303 yfhA Escherichia coli 55989 two component system DNA-binding response regulator YP_002403848.1 2910688 R 585055 CDS YP_002403849.1 218696182 7148757 complement(2912012..2912725) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2912725 yfhG 7148757 yfhG Escherichia coli 55989 hypothetical protein YP_002403849.1 2912012 R 585055 CDS YP_002403850.1 218696183 7148760 complement(2912890..2914317) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; sensory kinase in two-component system 2914317 yfhK 7148760 yfhK Escherichia coli 55989 sensory kinase in two-component system YP_002403850.1 2912890 R 585055 CDS YP_002403851.1 218696184 7147803 complement(2914893..2918780) 1 NC_011748.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase 2918780 purL 7147803 purL Escherichia coli 55989 phosphoribosylformylglycinamidine synthase YP_002403851.1 2914893 R 585055 CDS YP_002403852.1 218696185 7147300 2919176..2920594 1 NC_011748.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase 2920594 yfhD 7147300 yfhD Escherichia coli 55989 transglycosylase YP_002403852.1 2919176 D 585055 CDS YP_002403853.1 218696186 7148759 complement(2920591..2921127) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12110595; Product type e : enzyme; tRNA-specific adenosine deaminase 2921127 tadA 7148759 tadA Escherichia coli 55989 tRNA-specific adenosine deaminase YP_002403853.1 2920591 R 585055 CDS YP_002403854.1 218696187 7147745 complement(2921152..2921787) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2921787 yfhB 7147745 yfhB Escherichia coli 55989 hypothetical protein YP_002403854.1 2921152 R 585055 CDS YP_002403855.1 218696188 7148758 2921996..2922844 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 2922844 yfhH 7148758 yfhH Escherichia coli 55989 DNA-binding transcriptional regulator YP_002403855.1 2921996 D 585055 CDS YP_002403856.1 218696189 7148761 2922900..2923160 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8765743, 8880900; Product type c : carrier; ferredoxin (4Fe-4S cluster-containing protein) (fdx-like) 2923160 yfhL 7148761 yfhL Escherichia coli 55989 ferredoxin (4Fe-4S cluster-containing protein) (fdx-like) YP_002403856.1 2922900 D 585055 CDS YP_002403857.1 218696190 7147582 complement(2923431..2923595) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2923595 7147582 EC55989_2850 Escherichia coli 55989 hypothetical protein YP_002403857.1 2923431 R 585055 CDS YP_002403858.1 218696191 7147583 complement(2923854..2924234) 1 NC_011748.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase 2924234 acpS 7147583 acpS Escherichia coli 55989 4'-phosphopantetheinyl transferase YP_002403858.1 2923854 R 585055 CDS YP_002403859.1 218696192 7145442 complement(2924234..2924965) 1 NC_011748.1 involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase 2924965 pdxJ 7145442 pdxJ Escherichia coli 55989 pyridoxine 5'-phosphate synthase YP_002403859.1 2924234 R 585055 CDS YP_002403860.1 218696193 7147127 complement(2924977..2925705) 1 NC_011748.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO 2925705 recO 7147127 recO Escherichia coli 55989 DNA repair protein RecO YP_002403860.1 2924977 R 585055 CDS YP_002403861.1 218696194 7147365 complement(2925717..2926622) 1 NC_011748.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era 2926622 era 7147365 era Escherichia coli 55989 GTP-binding protein Era YP_002403861.1 2925717 R 585055 CDS YP_002403862.1 218696195 7146020 complement(2926619..2927299) 1 NC_011748.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III 2927299 rnc 7146020 rnc Escherichia coli 55989 ribonuclease III YP_002403862.1 2926619 R 585055 CDS YP_002403863.1 218696196 7147445 complement(2927572..2928546) 1 NC_011748.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I 2928546 lepB 7147445 lepB Escherichia coli 55989 signal peptidase I YP_002403863.1 2927572 R 585055 CDS YP_002403864.1 218696197 7146688 complement(2928562..2930361) 1 NC_011748.1 binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA 2930361 lepA 7146688 lepA Escherichia coli 55989 GTP-binding protein LepA YP_002403864.1 2928562 R 585055 CDS YP_002403865.1 218696198 7146687 complement(2930559..2931038) 1 NC_011748.1 involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC 2931038 rseC 7146687 rseC Escherichia coli 55989 SoxR reducing system protein RseC YP_002403865.1 2930559 R 585055 CDS YP_002403866.1 218696199 7147532 complement(2931035..2931991) 1 NC_011748.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE 2931991 rseB 7147532 rseB Escherichia coli 55989 periplasmic negative regulator of sigmaE YP_002403866.1 2931035 R 585055 CDS YP_002403867.1 218696200 7147531 complement(2931991..2932641) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9159522, 97303092, 99431977, 7768826; Product type f : factor; anti-RNA polymerase sigma factor SigE 2932641 rseA 7147531 rseA Escherichia coli 55989 anti-RNA polymerase sigma factor SigE YP_002403867.1 2931991 R 585055 CDS YP_002403868.1 218696201 7147530 complement(2932674..2933249) 1 NC_011748.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE 2933249 rpoE 7147530 rpoE Escherichia coli 55989 RNA polymerase sigma factor RpoE YP_002403868.1 2932674 R 585055 CDS YP_002403869.1 218696202 7147499 2933657..2935279 1 NC_011748.1 catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2935279 nadB 7147499 nadB Escherichia coli 55989 L-aspartate oxidase YP_002403869.1 2933657 D 585055 CDS YP_002403870.1 218696203 7146943 complement(2935264..2936001) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; S-adenosyl-L-methionine-dependent methyltransferase 2936001 yfiC 7146943 yfiC Escherichia coli 55989 S-adenosyl-L-methionine-dependent methyltransferase YP_002403870.1 2935264 R 585055 CDS YP_002403871.1 218696204 7148770 2936133..2937467 1 NC_011748.1 facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2937467 srmB 7148770 srmB Escherichia coli 55989 ATP-dependent RNA helicase SrmB YP_002403871.1 2936133 D 585055 CDS YP_002403872.1 218696205 7147707 complement(2937676..2938557) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 2938557 yfiE 7147707 yfiE Escherichia coli 55989 DNA-binding transcriptional regulator YP_002403872.1 2937676 R 585055 CDS YP_002403873.1 218696206 7148772 2938660..2939247 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12562784; Product type t : transporter; neutral amino-acid efflux protein 2939247 yfiK 7148772 yfiK Escherichia coli 55989 neutral amino-acid efflux protein YP_002403873.1 2938660 D 585055 CDS YP_002403874.1 218696207 7148775 complement(2939302..2939685) 1 NC_011748.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA 2939685 yfiD 7148775 yfiD Escherichia coli 55989 autonomous glycyl radical cofactor GrcA YP_002403874.1 2939302 R 585055 CDS YP_002403875.1 218696208 7148771 2939990..2940679 1 NC_011748.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2940679 ung 7148771 ung Escherichia coli 55989 uracil-DNA glycosylase YP_002403875.1 2939990 D 585055 CDS YP_002403876.1 218696209 7147923 complement(2940727..2941764) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; methyltransferase 2941764 yfiF 7147923 yfiF Escherichia coli 55989 methyltransferase YP_002403876.1 2940727 R 585055 CDS YP_002403877.1 218696210 7148773 complement(2941754..2941957) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Z3866 protein 2941957 7148773 EC55989_2871 Escherichia coli 55989 Z3866 protein YP_002403877.1 2941754 R 585055 CDS YP_002403878.1 218696211 7144831 2941971..2942390 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12952960, 9388228, 99175138, 10644706; Product type c : carrier; thioredoxin 2 2942390 trxC 7144831 trxC Escherichia coli 55989 thioredoxin 2 YP_002403878.1 2941971 D 585055 CDS YP_002403879.1 218696212 7147864 2942459..2943157 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2943157 yfiP 7147864 yfiP Escherichia coli 55989 hypothetical protein YP_002403879.1 2942459 D 585055 CDS YP_002403880.1 218696213 7148780 2943189..2945849 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; fused acyl-CoA synthetase: NAD(P)-binding subunit ; ATP-binding subunit 2945849 yfiQ 7148780 yfiQ Escherichia coli 55989 fused acyl-CoA synthetase: NAD(P)-binding subunit ; ATP-binding subunit YP_002403880.1 2943189 D 585055 CDS YP_002403881.1 218696214 7148781 2945963..2947318 1 NC_011748.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2947318 pssA 7148781 pssA Escherichia coli 55989 phosphatidylserine synthase YP_002403881.1 2945963 D 585055 CDS YP_002403882.1 218696215 7147276 2947415..2947687 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2947687 yfiM 7147276 yfiM Escherichia coli 55989 hypothetical protein YP_002403882.1 2947415 D 585055 CDS YP_002403883.1 218696216 7148777 complement(2947684..2948982) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91219460, 1709493, 2053984, 2118499, 2190187, 8419306; Product type t : transporter; alpha-ketoglutarate transporter 2948982 kgtP 7148777 kgtP Escherichia coli 55989 alpha-ketoglutarate transporter YP_002403883.1 2947684 R 585055 CDS YP_002403884.1 218696217 7144633 complement(2954848..2957421) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14550559, 14640692, 91294166, 93015925, 93388583, 99428468; Product type f : factor; protein disaggregation chaperone 2957421 clpB 7144633 clpB Escherichia coli 55989 protein disaggregation chaperone YP_002403884.1 2954848 R 585055 CDS YP_002403885.1 218696218 7147584 complement(2957551..2958282) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1906060, 2066329; hypothetical protein 2958282 yfiH 7147584 yfiH Escherichia coli 55989 hypothetical protein YP_002403885.1 2957551 R 585055 CDS YP_002403886.1 218696219 7148774 complement(2958279..2959259) 1 NC_011748.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D 2959259 rluD 7148774 rluD Escherichia coli 55989 23S rRNA pseudouridine synthase D YP_002403886.1 2958279 R 585055 CDS YP_002403887.1 218696220 7147429 2959394..2960131 1 NC_011748.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2960131 yfiO 7147429 yfiO Escherichia coli 55989 outer membrane protein assembly complex subunit YfiO YP_002403887.1 2959394 D 585055 CDS YP_002403888.1 218696221 7148779 2960402..2960743 1 NC_011748.1 associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2960743 yfiA 7148779 yfiA Escherichia coli 55989 translation inhibitor protein RaiA YP_002403888.1 2960402 D 585055 CDS YP_002403890.1 218696223 7147158 2960993..2962153 1 NC_011748.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2962153 pheA 7147158 pheA Escherichia coli 55989 bifunctional chorismate mutase/prephenate dehydratase YP_002403890.1 2960993 D 585055 CDS YP_002403891.1 218696224 7147157 complement(2962196..2963317) 1 NC_011748.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase 2963317 tyrA 7147157 tyrA Escherichia coli 55989 bifunctional chorismate mutase/prephenate dehydrogenase YP_002403891.1 2962196 R 585055 CDS YP_002403892.1 218696225 7147881 complement(2963328..2964398) 1 NC_011748.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 2964398 aroF 7147881 aroF Escherichia coli 55989 phospho-2-dehydro-3-deoxyheptonate aldolase YP_002403892.1 2963328 R 585055 CDS YP_002403893.1 218696226 7145544 2964608..2964973 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6396419; hypothetical protein 2964973 yfiL 7145544 yfiL Escherichia coli 55989 hypothetical protein YP_002403893.1 2964608 D 585055 CDS YP_002403894.1 218696227 7148776 2965123..2965641 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2965641 yfiR 7148776 yfiR Escherichia coli 55989 hypothetical protein YP_002403894.1 2965123 D 585055 CDS YP_002403895.1 218696228 7148782 2965631..2966857 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; hypothetical protein 2966857 yfiN 7148782 yfiN Escherichia coli 55989 hypothetical protein YP_002403895.1 2965631 D 585055 CDS YP_002403896.1 218696229 7148778 2966873..2967355 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96032391; Product type pm : membrane component; outer membrane lipoprotein 2967355 yfiB 7148778 yfiB Escherichia coli 55989 outer membrane lipoprotein YP_002403896.1 2966873 D 585055 CDS YP_002403897.1 218696230 7148769 complement(2967432..2967779) 1 NC_011748.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 2967779 rplS 7148769 rplS Escherichia coli 55989 50S ribosomal protein L19 YP_002403897.1 2967432 R 585055 CDS YP_002403898.1 218696231 7147479 complement(2967821..2968588) 1 NC_011748.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase 2968588 trmD 7147479 trmD Escherichia coli 55989 tRNA (guanine-N(1)-)-methyltransferase YP_002403898.1 2967821 R 585055 CDS YP_002403899.1 218696232 7147846 complement(2968619..2969167) 1 NC_011748.1 Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM 2969167 rimM 7147846 rimM Escherichia coli 55989 16S rRNA-processing protein RimM YP_002403899.1 2968619 R 585055 CDS YP_002403900.1 218696233 7147422 complement(2969186..2969434) 1 NC_011748.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 2969434 rpsP 7147422 rpsP Escherichia coli 55989 30S ribosomal protein S16 YP_002403900.1 2969186 R 585055 CDS YP_002403901.1 218696234 7147520 complement(2969571..2970932) 1 NC_011748.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein 2970932 ffh 7147520 ffh Escherichia coli 55989 signal recognition particle protein YP_002403901.1 2969571 R 585055 CDS YP_002403902.1 218696235 7146095 2971024..2971890 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2971890 ypjD 7146095 ypjD Escherichia coli 55989 inner membrane protein YP_002403902.1 2971024 D 585055 CDS YP_002403903.1 218696236 7149388 2972001..2973197 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2973197 yfjD 7149388 yfjD Escherichia coli 55989 hypothetical protein YP_002403903.1 2972001 D 585055 CDS YP_002403904.1 218696237 7148784 complement(2973252..2973845) 1 NC_011748.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE 2973845 grpE 7148784 grpE Escherichia coli 55989 heat shock protein GrpE YP_002403904.1 2973252 R 585055 CDS YP_002403905.1 218696238 7146369 2973968..2974846 1 NC_011748.1 catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2974846 ppnK 7146369 ppnK Escherichia coli 55989 inorganic polyphosphate/ATP-NAD kinase YP_002403905.1 2973968 D 585055 CDS YP_002403906.1 218696239 7148783 2974932..2976593 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87259985, 91355307, 95058623, 3037486; Product type cp : cell process; recombination and repair protein 2976593 recN 7148783 recN Escherichia coli 55989 recombination and repair protein YP_002403906.1 2974932 D 585055 CDS YP_002403907.1 218696240 7147364 2976742..2977083 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2045357; Product type lp : lipoprotein; hypothetical protein 2977083 smpA 7147364 smpA Escherichia coli 55989 hypothetical protein YP_002403907.1 2976742 D 585055 CDS YP_002403908.1 218696241 7147668 complement(2977145..2977435) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2977435 yfjF 7147668 yfjF Escherichia coli 55989 hypothetical protein YP_002403908.1 2977145 R 585055 CDS YP_002403909.1 218696242 7148785 complement(2977425..2977901) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2977901 yfjG 7148785 yfjG Escherichia coli 55989 hypothetical protein YP_002403909.1 2977425 R 585055 CDS YP_002403910.1 218696243 7148786 2978033..2978515 1 NC_011748.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2978515 smpB 7148786 smpB Escherichia coli 55989 SsrA-binding protein YP_002403910.1 2978033 D 585055 CDS YP_002403911.1 218696244 7147716 2979298..2980539 1 NC_011748.1 CP4-57 prophage; integrase; integrase 2980539 intA 7147716 intA Escherichia coli 55989 integrase YP_002403911.1 2979298 D 585055 CDS YP_002403912.1 218696245 7146607 complement(2980678..2984424) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2984424 7146607 EC55989_2910 Escherichia coli 55989 hypothetical protein YP_002403912.1 2980678 R 585055 CDS YP_002403913.1 218696246 7144832 2984892..2988743 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2988743 7144832 EC55989_2911 Escherichia coli 55989 hypothetical protein YP_002403913.1 2984892 D 585055 CDS YP_002403914.1 218696247 7144833 2988789..2989535 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2989535 7144833 EC55989_2912 Escherichia coli 55989 hypothetical protein YP_002403914.1 2988789 D 585055 CDS YP_002403915.1 218696248 7144834 2989387..2989701 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2989701 7144834 EC55989_2913 Escherichia coli 55989 hypothetical protein YP_002403915.1 2989387 D 585055 CDS YP_002403916.1 218696249 7144835 complement(2989786..2989944) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2989944 7144835 EC55989_2914 Escherichia coli 55989 hypothetical protein YP_002403916.1 2989786 R 585055 CDS YP_002403917.1 218696250 7144836 complement(2989969..2990850) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2990850 7144836 EC55989_2915 Escherichia coli 55989 hypothetical protein YP_002403917.1 2989969 R 585055 CDS YP_002403918.1 218696251 7144837 2991369..2991668 1 NC_011748.1 Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; GTP-binding factor (fragment) from CP4-like prophage 2991668 7144837 EC55989_2916 Escherichia coli 55989 GTP-binding factor (fragment) from CP4-like prophage YP_002403918.1 2991369 D 585055 CDS YP_002403919.1 218696252 7144838 2991689..2992036 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase ORF A, IS3 family 2992036 7144838 EC55989_2917 Escherichia coli 55989 transposase ORF A, IS3 family YP_002403919.1 2991689 D 585055 CDS YP_002403920.1 218696253 7144840 complement(2992872..2993471) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; outer membrane protein 2993471 7144840 EC55989_2919 Escherichia coli 55989 outer membrane protein YP_002403920.1 2992872 R 585055 CDS YP_002403921.1 218696254 7144843 complement(2996141..2996470) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 2996470 7144843 EC55989_2923 Escherichia coli 55989 hypothetical protein YP_002403921.1 2996141 R 585055 CDS YP_002403922.1 218696255 7144846 2998993..2999265 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2999265 yqaD 7144846 yqaD Escherichia coli 55989 hypothetical protein YP_002403922.1 2998993 D 585055 CDS YP_002403923.1 218696256 7149391 2999601..3000578 1 NC_011748.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 3000578 ygaT 7149391 ygaT Escherichia coli 55989 hypothetical protein YP_002403923.1 2999601 D 585055 CDS YP_002403924.1 218696257 7148794 3000598..3001866 1 NC_011748.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 3001866 ygaF 7148794 ygaF Escherichia coli 55989 hydroxyglutarate oxidase YP_002403924.1 3000598 D 585055 CDS YP_002403925.1 218696258 7148790 3001889..3003337 1 NC_011748.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 3003337 gabD 7148790 gabD Escherichia coli 55989 succinate-semialdehyde dehydrogenase I YP_002403925.1 3001889 D 585055 CDS YP_002403926.1 218696259 7146237 3003351..3004631 1 NC_011748.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 3004631 gabT 7146237 gabT Escherichia coli 55989 4-aminobutyrate aminotransferase YP_002403926.1 3003351 D 585055 CDS YP_002403927.1 218696260 7146239 3004942..3006342 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94127927, 9685361, 8297211; Product type t : transporter; gamma-aminobutyrate transporter 3006342 gabP 7146239 gabP Escherichia coli 55989 gamma-aminobutyrate transporter YP_002403927.1 3004942 D 585055 CDS YP_002403928.1 218696261 7146238 3006363..3007025 1 NC_011748.1 regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 3007025 csiR 7146238 csiR Escherichia coli 55989 DNA-binding transcriptional regulator CsiR YP_002403928.1 3006363 D 585055 CDS YP_002403929.1 218696262 7145776 complement(3007026..3007475) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; LysM domain/BON superfamily protein 3007475 ygaU 7145776 ygaU Escherichia coli 55989 LysM domain/BON superfamily protein YP_002403929.1 3007026 R 585055 CDS YP_002403930.1 218696263 7148795 complement(3007559..3007717) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 3007717 yqaE 7148795 yqaE Escherichia coli 55989 hypothetical protein YP_002403930.1 3007559 R 585055 CDS YP_002403931.1 218696264 7149392 3007900..3008199 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 3008199 ygaV 7149392 ygaV Escherichia coli 55989 DNA-binding transcriptional regulator YP_002403931.1 3007900 D 585055 CDS YP_002403932.1 218696265 7148796 3008209..3008733 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : enzyme; inner membrane protein with hydrolase activity 3008733 ygaP 7148796 ygaP Escherichia coli 55989 inner membrane protein with hydrolase activity YP_002403932.1 3008209 D 585055 CDS YP_002403933.1 218696266 7148793 complement(3008780..3009184) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20485613, 93126121, 9643551, 98132400, 99415935, 1480493, 7961433; Product type r : regulator; DNA binding protein 3009184 stpA 7148793 stpA Escherichia coli 55989 DNA binding protein YP_002403933.1 3008780 R 585055 CDS YP_002403934.1 218696267 7147725 3009852..3010301 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3010301 ygaW 7147725 ygaW Escherichia coli 55989 inner membrane protein YP_002403934.1 3009852 D 585055 CDS YP_002403935.1 218696268 7148797 complement(3010338..3010682) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7961433; hypothetical protein 3010682 ygaC 7148797 ygaC Escherichia coli 55989 hypothetical protein YP_002403935.1 3010338 R 585055 CDS YP_002403936.1 218696269 7148788 3010822..3011163 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3011163 ygaM 7148788 ygaM Escherichia coli 55989 hypothetical protein YP_002403936.1 3010822 D 585055 CDS YP_002403937.1 218696270 7148792 3011411..3011656 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9218434, 11441020, 8820648; Product type pc : carrier; glutaredoxin-like protein 3011656 nrdH 7148792 nrdH Escherichia coli 55989 glutaredoxin-like protein YP_002403937.1 3011411 D 585055 CDS YP_002403938.1 218696271 7147024 3011653..3012063 1 NC_011748.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 3012063 nrdI 7147024 nrdI Escherichia coli 55989 ribonucleotide reductase stimulatory protein YP_002403938.1 3011653 D 585055 CDS YP_002403939.1 218696272 7147025 3012036..3014180 1 NC_011748.1 Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3014180 nrdE 7147025 nrdE Escherichia coli 55989 ribonucleotide-diphosphate reductase subunit alpha YP_002403939.1 3012036 D 585055 CDS YP_002403940.1 218696273 7147021 3014190..3015149 1 NC_011748.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 3015149 nrdF 7147021 nrdF Escherichia coli 55989 ribonucleotide-diphosphate reductase subunit beta YP_002403940.1 3014190 D 585055 CDS YP_002403941.1 218696274 7147022 3015504..3016706 1 NC_011748.1 with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 3016706 proV 7147022 proV Escherichia coli 55989 glycine betaine transporter ATP-binding subunit YP_002403941.1 3015504 D 585055 CDS YP_002403942.1 218696275 7147258 3016699..3017763 1 NC_011748.1 with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 3017763 proW 7147258 proW Escherichia coli 55989 glycine betaine transporter membrane protein YP_002403942.1 3016699 D 585055 CDS YP_002403943.1 218696276 7147259 3017820..3018812 1 NC_011748.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 3018812 proX 7147259 proX Escherichia coli 55989 glycine betaine transporter periplasmic subunit YP_002403943.1 3017820 D 585055 CDS YP_002403944.1 218696277 7147260 3019004..3020188 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16000740; Product type pt : transporter; transport protein (ousB-like) 3020188 7147260 EC55989_2948 Escherichia coli 55989 transport protein (ousB-like) YP_002403944.1 3019004 D 585055 CDS YP_002403945.1 218696278 7144847 3020312..3021049 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 3021049 ygaZ 7144847 ygaZ Escherichia coli 55989 transporter YP_002403945.1 3020312 D 585055 CDS YP_002403946.1 218696279 7148798 3021039..3021374 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 3021374 ygaH 7148798 ygaH Escherichia coli 55989 hypothetical protein YP_002403946.1 3021039 D 585055 CDS YP_002403947.1 218696280 7148791 3021465..3021995 1 NC_011748.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 3021995 mprA 7148791 mprA Escherichia coli 55989 transcriptional repressor MprA YP_002403947.1 3021465 D 585055 CDS YP_002403948.1 218696281 7146893 3022122..3023294 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590, 8203018; Product type t : transporter; multidrug efflux system 3023294 emrA 7146893 emrA Escherichia coli 55989 multidrug efflux system YP_002403948.1 3022122 D 585055 CDS YP_002403949.1 218696282 7145989 3023311..3024849 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590; Product type t : transporter; multidrug efflux system protein 3024849 emrB 7145989 emrB Escherichia coli 55989 multidrug efflux system protein YP_002403949.1 3023311 D 585055 CDS YP_002403950.1 218696283 7145990 complement(3024913..3025428) 1 NC_011748.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase 3025428 luxS 7145990 luxS Escherichia coli 55989 S-ribosylhomocysteinase YP_002403950.1 3024913 R 585055 CDS YP_002403951.1 218696284 7146854 complement(3025578..3027134) 1 NC_011748.1 involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase 3027134 gshA 7146854 gshA Escherichia coli 55989 glutamate--cysteine ligase YP_002403951.1 3025578 R 585055 CDS YP_002403952.1 218696285 7146373 complement(3027207..3027635) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3027635 yqaA 7146373 yqaA Escherichia coli 55989 inner membrane protein YP_002403952.1 3027207 R 585055 CDS YP_002403953.1 218696286 7149389 complement(3027632..3028198) 1 NC_011748.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase 3028198 yqaB 7149389 yqaB Escherichia coli 55989 fructose-1-phosphatase YP_002403953.1 3027632 R 585055 CDS YP_002403954.1 218696287 7145380 complement(3029791..3029976) 1 NC_011748.1 affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator 3029976 csrA 7145380 csrA Escherichia coli 55989 carbon storage regulator YP_002403954.1 3029791 R 585055 CDS YP_002403955.1 218696288 7145783 complement(3030211..3032841) 1 NC_011748.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase 3032841 alaS 7145783 alaS Escherichia coli 55989 alanyl-tRNA synthetase YP_002403955.1 3030211 R 585055 CDS YP_002403956.1 218696289 7145478 complement(3032969..3033469) 1 NC_011748.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX 3033469 recX 7145478 recX Escherichia coli 55989 recombination regulator RecX YP_002403956.1 3032969 R 585055 CDS YP_002403957.1 218696290 7147368 complement(3033712..3034773) 1 NC_011748.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A 3034773 recA 7147368 recA Escherichia coli 55989 recombinase A YP_002403957.1 3033712 R 585055 CDS YP_002403958.1 218696291 7147357 complement(3034853..3035350) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A 3035350 ygaD 7147357 ygaD Escherichia coli 55989 competence damage-inducible protein A YP_002403958.1 3034853 R 585055 CDS YP_002403959.1 218696292 7148789 complement(3035495..3036580) 1 NC_011748.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B 3036580 mltB 7148789 mltB Escherichia coli 55989 murein hydrolase B YP_002403959.1 3035495 R 585055 CDS YP_002403960.1 218696293 7146864 3036836..3037399 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87194727, 1334233, 3553176; Product type t : transporter; PTS system glucitol/sorbitol-specific transporter subunit IIC 3037399 srlA 7146864 srlA Escherichia coli 55989 PTS system glucitol/sorbitol-specific transporter subunit IIC YP_002403960.1 3036836 D 585055 CDS YP_002403961.1 218696294 7147702 3037396..3038355 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1100602, 3553176; Product type t : transporter; glucitol/sorbitol-specific enzyme IIB component of PTS 3038355 srlE 7147702 srlE Escherichia coli 55989 glucitol/sorbitol-specific enzyme IIB component of PTS YP_002403961.1 3037396 D 585055 CDS YP_002403962.1 218696295 7147705 3038366..3038737 1 NC_011748.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 3038737 srlB 7147705 srlB Escherichia coli 55989 PTS system glucitol/sorbitol-specific transporter subunit IIA YP_002403962.1 3038366 D 585055 CDS YP_002403963.1 218696296 7147703 3038741..3039520 1 NC_011748.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 3039520 srlD 7147703 srlD Escherichia coli 55989 sorbitol-6-phosphate dehydrogenase YP_002403963.1 3038741 D 585055 CDS YP_002403964.1 218696297 7147704 3039625..3039984 1 NC_011748.1 regulator for glucitol utilization; DNA-binding transcriptional activator GutM 3039984 gutM 7147704 gutM Escherichia coli 55989 DNA-binding transcriptional activator GutM YP_002403964.1 3039625 D 585055 CDS YP_002403965.1 218696298 7146386 3040051..3040824 1 NC_011748.1 regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 3040824 srlR 7146386 srlR Escherichia coli 55989 DNA-binding transcriptional repressor SrlR YP_002403965.1 3040051 D 585055 CDS YP_002403966.1 218696299 7147706 3040817..3041782 1 NC_011748.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 3041782 gutQ 7147706 gutQ Escherichia coli 55989 D-arabinose 5-phosphate isomerase YP_002403966.1 3040817 D 585055 CDS YP_002403967.1 218696300 7146387 complement(3041779..3043293) 1 NC_011748.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcriptional regulator 3043293 norR 7146387 norR Escherichia coli 55989 anaerobic nitric oxide reductase transcriptional regulator YP_002403967.1 3041779 R 585055 CDS YP_002403968.1 218696301 7147014 3043480..3044919 1 NC_011748.1 detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 3044919 norV 7147014 norV Escherichia coli 55989 anaerobic nitric oxide reductase flavorubredoxin YP_002403968.1 3043480 D 585055 CDS YP_002403969.1 218696302 7147015 3044916..3046049 1 NC_011748.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 3046049 norW 7147015 norW Escherichia coli 55989 nitric oxide reductase YP_002403969.1 3044916 D 585055 CDS YP_002403970.1 218696303 7145652 complement(3046275..3048527) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12377778, 92255260, 8661925; Product type e : enzyme; carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases 3048527 hypF 7145652 hypF Escherichia coli 55989 carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases YP_002403970.1 3046275 R 585055 CDS YP_002403971.1 218696304 7146525 complement(3048680..3049207) 1 NC_011748.1 involved in electron transport from formate to hydrogen; electron transport protein HydN 3049207 hydN 7146525 hydN Escherichia coli 55989 electron transport protein HydN YP_002403971.1 3048680 R 585055 CDS YP_002403972.1 218696305 7146505 complement(3049356..3050369) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88297127, 92334140, 1630307; Product type r : regulator; DNA-binding transcriptional repressor 3050369 ascG 7146505 ascG Escherichia coli 55989 DNA-binding transcriptional repressor YP_002403972.1 3049356 R 585055 CDS YP_002403973.1 218696306 7145562 3050626..3052083 1 NC_011748.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunit IIBC 3052083 ascF 7145562 ascF Escherichia coli 55989 PTS system cellobiose/arbutin/salicin-specific transporter subunit IIBC YP_002403973.1 3050626 D 585055 CDS YP_002403974.1 218696307 7145561 3052092..3053516 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88297127, 92334140, 1630307; Product type e : enzyme; cryptic 6-phospho-beta-glucosidase 3053516 ascB 7145561 ascB Escherichia coli 55989 cryptic 6-phospho-beta-glucosidase YP_002403974.1 3052092 D 585055 CDS YP_002403975.1 218696308 7145560 complement(3053684..3054664) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 3054664 7145560 EC55989_2979 Escherichia coli 55989 transposase, IS110 family YP_002403975.1 3053684 R 585055 CDS YP_002403976.1 218696309 7144848 complement(3054909..3055394) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; HTH-type transcriptional regulator ygjM 3055394 7144848 EC55989_2981 Escherichia coli 55989 HTH-type transcriptional regulator ygjM YP_002403976.1 3054909 R 585055 CDS YP_002403977.1 218696310 7144849 complement(3055399..3056172) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3056172 7144849 EC55989_2982 Escherichia coli 55989 hypothetical protein YP_002403977.1 3055399 R 585055 CDS YP_002403978.1 218696311 7144850 complement(3056197..3056667) 1 NC_011748.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease 3056667 hycI 7144850 hycI Escherichia coli 55989 hydrogenase 3 maturation protease YP_002403978.1 3056197 R 585055 CDS YP_002403979.1 218696312 7146504 complement(3056660..3057070) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 1625581, 2187144, 7851435; Product type f : factor; protein required for maturation of hydrogenase 3 3057070 hycH 7146504 hycH Escherichia coli 55989 protein required for maturation of hydrogenase 3 YP_002403979.1 3056660 R 585055 CDS YP_002403980.1 218696313 7146503 complement(3057067..3057834) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type e : enzyme; hydrogenase 3 and formate hydrogenase complex, HycG subunit 3057834 hycG 7146503 hycG Escherichia coli 55989 hydrogenase 3 and formate hydrogenase complex, HycG subunit YP_002403980.1 3057067 R 585055 CDS YP_002403981.1 218696314 7146502 complement(3057834..3058376) 1 NC_011748.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit 3058376 hycF 7146502 hycF Escherichia coli 55989 formate hydrogenlyase complex iron-sulfur subunit YP_002403981.1 3057834 R 585055 CDS YP_002403982.1 218696315 7146501 complement(3058386..3060095) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 94170785, 2187144, 8125094; Product type e : enzyme; hydrogenase 3, large subunit 3060095 hycE 7146501 hycE Escherichia coli 55989 hydrogenase 3, large subunit YP_002403982.1 3058386 R 585055 CDS YP_002403983.1 218696316 7146500 complement(3060113..3061036) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636; Product type m : membrane component; hydrogenase 3, membrane subunit 3061036 hycD 7146500 hycD Escherichia coli 55989 hydrogenase 3, membrane subunit YP_002403983.1 3060113 R 585055 CDS YP_002403984.1 218696317 7146499 complement(3061039..3062865) 1 NC_011748.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 3062865 hycC 7146499 hycC Escherichia coli 55989 formate hydrogenlyase subunit 3 YP_002403984.1 3061039 R 585055 CDS YP_002403985.1 218696318 7146498 complement(3062862..3063473) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type c : carrier; hydrogenase 3, Fe-S subunit 3063473 hycB 7146498 hycB Escherichia coli 55989 hydrogenase 3, Fe-S subunit YP_002403985.1 3062862 R 585055 CDS YP_002403986.1 218696319 7146497 complement(3063598..3064059) 1 NC_011748.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA 3064059 hycA 7146497 hycA Escherichia coli 55989 formate hydrogenlyase regulatory protein HycA YP_002403986.1 3063598 R 585055 CDS YP_002403987.1 218696320 7146496 3064270..3064620 1 NC_011748.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 3064620 hypA 7146496 hypA Escherichia coli 55989 hydrogenase nickel incorporation protein YP_002403987.1 3064270 D 585055 CDS YP_002403988.1 218696321 7146520 3064624..3065496 1 NC_011748.1 GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 3065496 hypB 7146520 hypB Escherichia coli 55989 hydrogenase nickel incorporation protein HypB YP_002403988.1 3064624 D 585055 CDS YP_002403989.1 218696322 7146521 3065487..3065759 1 NC_011748.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 3065759 hypC 7146521 hypC Escherichia coli 55989 hydrogenase assembly chaperone YP_002403989.1 3065487 D 585055 CDS YP_002403990.1 218696323 7146522 3065759..3066880 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 92255260, 1849603; Product type f : factor; hydrogenase maturation protein 3066880 hypD 7146522 hypD Escherichia coli 55989 hydrogenase maturation protein YP_002403990.1 3065759 D 585055 CDS YP_002403991.1 218696324 7146523 3066919..3067887 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 9485446, 1849603; Product type e : enzyme; carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein 3067887 hypE 7146523 hypE Escherichia coli 55989 carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein YP_002403991.1 3066919 D 585055 CDS YP_002403992.1 218696325 7146524 3067961..3070039 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20307603, 21557168, 90368529, 92140045, 94018617, 2118503, 2280686; Product type r : regulator; DNA-binding transcriptional activator 3070039 fhlA 7146524 fhlA Escherichia coli 55989 DNA-binding transcriptional activator YP_002403992.1 3067961 D 585055 CDS YP_002403993.1 218696326 7146098 complement(3070076..3070429) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3070429 ygbA 7146098 ygbA Escherichia coli 55989 hypothetical protein YP_002403993.1 3070076 R 585055 CDS YP_002403994.1 218696327 7148799 3070716..3073277 1 NC_011748.1 This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 3073277 mutS 7148799 mutS Escherichia coli 55989 DNA mismatch repair protein MutS YP_002403994.1 3070716 D 585055 CDS YP_002403995.1 218696328 7146934 3073383..3074039 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9130712; Product type e : enzyme; serine/threonine-specific protein phosphatase 2 3074039 pphB 7146934 pphB Escherichia coli 55989 serine/threonine-specific protein phosphatase 2 YP_002403995.1 3073383 D 585055 CDS YP_002403996.1 218696329 7147227 complement(3074090..3074887) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 3074887 ygbI 7147227 ygbI Escherichia coli 55989 DNA-binding transcriptional regulator YP_002403996.1 3074090 R 585055 CDS YP_002403997.1 218696330 7148802 3075053..3075961 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; dehydrogenase, with NAD(P)-binding Rossmann-fold domain 3075961 ygbJ 7148802 ygbJ Escherichia coli 55989 dehydrogenase, with NAD(P)-binding Rossmann-fold domain YP_002403997.1 3075053 D 585055 CDS YP_002403998.1 218696331 7148803 3075958..3077220 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11520622; hypothetical protein 3077220 ygbK 7148803 ygbK Escherichia coli 55989 hypothetical protein YP_002403998.1 3075958 D 585055 CDS YP_002403999.1 218696332 7148804 3077217..3077855 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; aldolase 3077855 ygbL 7148804 ygbL Escherichia coli 55989 aldolase YP_002403999.1 3077217 D 585055 CDS YP_002404000.1 218696333 7148805 3077860..3078636 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3078636 ygbM 7148805 ygbM Escherichia coli 55989 hypothetical protein YP_002404000.1 3077860 D 585055 CDS YP_002404001.1 218696334 7148806 3078725..3080089 1 NC_011748.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; inner membrane permease YgbN 3080089 ygbN 7148806 ygbN Escherichia coli 55989 inner membrane permease YgbN YP_002404001.1 3078725 D 585055 CDS YP_002404002.1 218696335 7148807 complement(3080129..3080365) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; conserved non-oxidative reversible hydroxyarylic acid decarboxylase 3080365 7148807 EC55989_3008 Escherichia coli 55989 conserved non-oxidative reversible hydroxyarylic acid decarboxylase YP_002404002.1 3080129 R 585055 CDS YP_002404003.1 218696336 7144851 complement(3080376..3081803) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; conserved non-oxidative hydroxyarylic acid decarboxylase activity 3081803 7144851 EC55989_3009 Escherichia coli 55989 conserved non-oxidative hydroxyarylic acid decarboxylase activity YP_002404003.1 3080376 R 585055 CDS YP_002404004.1 218696337 7144852 complement(3081803..3082396) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; conserved non-oxidative reversible hydroxyarylic acid decarboxylase 3082396 7144852 EC55989_3010 Escherichia coli 55989 conserved non-oxidative reversible hydroxyarylic acid decarboxylase YP_002404004.1 3081803 R 585055 CDS YP_002404005.1 218696338 7144853 3082543..3082950 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15731069; Product type r : regulator; Transcriptional regulator hosA 3082950 7144853 EC55989_3011 Escherichia coli 55989 Transcriptional regulator hosA YP_002404005.1 3082543 D 585055 CDS YP_002404006.1 218696339 7144854 complement(3083071..3084063) 1 NC_011748.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS 3084063 rpoS 7144854 rpoS Escherichia coli 55989 RNA polymerase sigma factor RpoS YP_002404006.1 3083071 R 585055 CDS YP_002404007.1 218696340 7147502 complement(3084126..3085265) 1 NC_011748.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD 3085265 nlpD 7147502 nlpD Escherichia coli 55989 lipoprotein NlpD YP_002404007.1 3084126 R 585055 CDS YP_002404008.1 218696341 7147009 complement(3085405..3086031) 1 NC_011748.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase 3086031 pcm 7147009 pcm Escherichia coli 55989 protein-L-isoaspartate O-methyltransferase YP_002404008.1 3085405 R 585055 CDS YP_002404009.1 218696342 7147121 complement(3086025..3086786) 1 NC_011748.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE 3086786 surE 7147121 surE Escherichia coli 55989 stationary phase survival protein SurE YP_002404009.1 3086025 R 585055 CDS YP_002404010.1 218696343 7147741 complement(3086767..3087816) 1 NC_011748.1 catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D 3087816 truD 7147741 truD Escherichia coli 55989 tRNA pseudouridine synthase D YP_002404010.1 3086767 R 585055 CDS YP_002404011.1 218696344 7147861 complement(3087813..3088292) 1 NC_011748.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase 3088292 ispF 7147861 ispF Escherichia coli 55989 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase YP_002404011.1 3087813 R 585055 CDS YP_002404012.1 218696345 7146629 complement(3088292..3089002) 1 NC_011748.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase 3089002 ispD 7146629 ispD Escherichia coli 55989 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase YP_002404012.1 3088292 R 585055 CDS YP_002404013.1 218696346 7146627 complement(3089021..3089332) 1 NC_011748.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB 3089332 ftsB 7146627 ftsB Escherichia coli 55989 cell division protein FtsB YP_002404013.1 3089021 R 585055 CDS YP_002404014.1 218696347 7146211 complement(3089526..3089849) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 3089849 ygbE 7146211 ygbE Escherichia coli 55989 hypothetical protein YP_002404014.1 3089526 R 585055 CDS YP_002404015.1 218696348 7148800 complement(3089899..3090504) 1 NC_011748.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase 3090504 cysC 7148800 cysC Escherichia coli 55989 adenylylsulfate kinase YP_002404015.1 3089899 R 585055 CDS YP_002404016.1 218696349 7145822 complement(3090504..3091931) 1 NC_011748.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 3091931 cysN 7145822 cysN Escherichia coli 55989 sulfate adenylyltransferase subunit 1 YP_002404016.1 3090504 R 585055 CDS YP_002404017.1 218696350 7145831 complement(3091933..3092841) 1 NC_011748.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 3092841 cysD 7145831 cysD Escherichia coli 55989 sulfate adenylyltransferase subunit 2 YP_002404017.1 3091933 R 585055 CDS YP_002404018.1 218696351 7145823 3093093..3094130 1 NC_011748.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase 3094130 iap 7145823 iap Escherichia coli 55989 alkaline phosphatase YP_002404018.1 3093093 D 585055 CDS YP_002404019.1 218696352 7146530 complement(3094398..3094691) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3094691 ygbF 7146530 ygbF Escherichia coli 55989 hypothetical protein YP_002404019.1 3094398 R 585055 CDS YP_002404020.1 218696353 7148801 complement(3094691..3095611) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3095611 ygbT 7148801 ygbT Escherichia coli 55989 hypothetical protein YP_002404020.1 3094691 R 585055 CDS YP_002404021.1 218696354 7148808 complement(3095608..3096396) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3096396 7148808 EC55989_3029 Escherichia coli 55989 hypothetical protein YP_002404021.1 3095608 R 585055 CDS YP_002404022.1 218696355 7144855 complement(3096240..3096986) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3096986 7144855 EC55989_3030 Escherichia coli 55989 hypothetical protein YP_002404022.1 3096240 R 585055 CDS YP_002404023.1 218696356 7144856 complement(3096997..3098052) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3098052 7144856 EC55989_3031 Escherichia coli 55989 hypothetical protein YP_002404023.1 3096997 R 585055 CDS YP_002404024.1 218696357 7144857 complement(3098064..3098600) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3098600 7144857 EC55989_3032 Escherichia coli 55989 hypothetical protein YP_002404024.1 3098064 R 585055 CDS YP_002404025.1 218696358 7144858 complement(3098597..3100228) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3100228 7144858 EC55989_3033 Escherichia coli 55989 hypothetical protein YP_002404025.1 3098597 R 585055 CDS YP_002404026.1 218696359 7144859 complement(3100257..3102956) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3102956 7144859 EC55989_3034 Escherichia coli 55989 hypothetical protein YP_002404026.1 3100257 R 585055 CDS YP_002404027.1 218696360 7144860 complement(3103150..3103302) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type pm : membrane component; small toxic peptide 3103302 7144860 EC55989_3035 Escherichia coli 55989 small toxic peptide YP_002404027.1 3103150 R 585055 CDS YP_002404028.1 218696361 7144861 complement(3103567..3104301) 1 NC_011748.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase 3104301 cysH 7144861 cysH Escherichia coli 55989 phosphoadenosine phosphosulfate reductase YP_002404028.1 3103567 R 585055 CDS YP_002404029.1 218696362 7145826 complement(3104375..3106087) 1 NC_011748.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta 3106087 cysI 7145826 cysI Escherichia coli 55989 sulfite reductase subunit beta YP_002404029.1 3104375 R 585055 CDS YP_002404030.1 218696363 7145827 complement(3106087..3107886) 1 NC_011748.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha 3107886 cysJ 7145827 cysJ Escherichia coli 55989 sulfite reductase subunit alpha YP_002404030.1 3106087 R 585055 CDS YP_002404031.1 218696364 7145828 3108202..3108567 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123838; Product type e : enzyme; 6-pyruvoyl tetrahydrobiopterin synthase 3108567 ygcM 7145828 ygcM Escherichia coli 55989 6-pyruvoyl tetrahydrobiopterin synthase YP_002404031.1 3108202 D 585055 CDS YP_002404032.1 218696365 7148812 3108645..3109916 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase with FAD/NAD(P)-binding domain 3109916 ygcN 7148812 ygcN Escherichia coli 55989 oxidoreductase with FAD/NAD(P)-binding domain YP_002404032.1 3108645 D 585055 CDS YP_002404033.1 218696366 7148813 3109907..3110167 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; 4Fe-4S binding protein 3110167 ygcO 7148813 ygcO Escherichia coli 55989 4Fe-4S binding protein YP_002404033.1 3109907 D 585055 CDS YP_002404034.1 218696367 7148814 3110184..3110759 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; anti-terminator regulatory protein 3110759 ygcP 7148814 ygcP Escherichia coli 55989 anti-terminator regulatory protein YP_002404034.1 3110184 D 585055 CDS YP_002404035.1 218696368 7148815 complement(3110907..3111767) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; flavoprotein 3111767 ygcQ 7148815 ygcQ Escherichia coli 55989 flavoprotein YP_002404035.1 3110907 R 585055 CDS YP_002404036.1 218696369 7148816 complement(3111764..3112543) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; flavoprotein 3112543 ygcR 7148816 ygcR Escherichia coli 55989 flavoprotein YP_002404036.1 3111764 R 585055 CDS YP_002404037.1 218696370 7148817 complement(3112521..3113858) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 3113858 ygcS 7148817 ygcS Escherichia coli 55989 transporter YP_002404037.1 3112521 R 585055 CDS YP_002404038.1 218696371 7148818 complement(3113952..3115406) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; FAD containing dehydrogenase 3115406 ygcU 7148818 ygcU Escherichia coli 55989 FAD containing dehydrogenase YP_002404038.1 3113952 R 585055 CDS YP_002404039.1 218696372 7148819 complement(3115476..3116261) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; deoxygluconate dehydrogenase 3116261 ygcW 7148819 ygcW Escherichia coli 55989 deoxygluconate dehydrogenase YP_002404039.1 3115476 R 585055 CDS YP_002404040.1 218696373 7148820 3116580..3117857 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 3117857 yqcE 7148820 yqcE Escherichia coli 55989 transporter YP_002404040.1 3116580 D 585055 CDS YP_002404041.1 218696374 7149395 3117884..3119362 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; kinase 3119362 ygcE 7149395 ygcE Escherichia coli 55989 kinase YP_002404041.1 3117884 D 585055 CDS YP_002404042.1 218696375 7148809 complement(3121284..3121955) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3121955 ygcF 7148809 ygcF Escherichia coli 55989 hypothetical protein YP_002404042.1 3121284 R 585055 CDS YP_002404043.1 218696376 7148810 3122416..3123120 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3123120 ygcG 7148810 ygcG Escherichia coli 55989 hypothetical protein YP_002404043.1 3122416 D 585055 CDS YP_002404044.1 218696377 7148811 3122930..3123196 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 3123196 7148811 EC55989_3053 Escherichia coli 55989 hypothetical protein YP_002404044.1 3122930 D 585055 CDS YP_002404045.1 218696378 7144862 complement(3123180..3124478) 1 NC_011748.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase 3124478 eno 7144862 eno Escherichia coli 55989 phosphopyruvate hydratase YP_002404045.1 3123180 R 585055 CDS YP_002404046.1 218696379 7145998 complement(3124566..3126203) 1 NC_011748.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase 3126203 pyrG 7145998 pyrG Escherichia coli 55989 CTP synthetase YP_002404046.1 3124566 R 585055 CDS YP_002404047.1 218696380 7147322 complement(3126431..3127222) 1 NC_011748.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase 3127222 mazG 7147322 mazG Escherichia coli 55989 nucleoside triphosphate pyrophosphohydrolase YP_002404047.1 3126431 R 585055 CDS YP_002404048.1 218696381 7146791 complement(3127293..3127628) 1 NC_011748.1 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA 3127628 chpA 7146791 chpA Escherichia coli 55989 toxin ChpA YP_002404048.1 3127293 R 585055 CDS YP_002404049.1 218696382 7145703 complement(3127628..3127876) 1 NC_011748.1 part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE 3127876 chpR 7145703 chpR Escherichia coli 55989 antitoxin MazE YP_002404049.1 3127628 R 585055 CDS YP_002404050.1 218696383 7145705 complement(3127954..3130188) 1 NC_011748.1 (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase 3130188 relA 7145705 relA Escherichia coli 55989 GDP/GTP pyrophosphokinase YP_002404050.1 3127954 R 585055 CDS YP_002404051.1 218696384 7147369 complement(3130236..3131537) 1 NC_011748.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase 3131537 rumA 7147369 rumA Escherichia coli 55989 23S rRNA 5-methyluridine methyltransferase YP_002404051.1 3130236 R 585055 CDS YP_002404052.1 218696385 7145595 3131952..3132227 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 375010, 1849492; Product type pe : enzyme; Insertion element IS1 protein insA 3132227 7145595 EC55989_3062 Escherichia coli 55989 Insertion element IS1 protein insA YP_002404052.1 3131952 D 585055 CDS YP_002404053.1 218696386 7144863 3132146..3132649 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 273224, 375010, 1849492; Product type pe : enzyme; Insertion element IS1 1/5/6 protein insB 3132649 7144863 EC55989_3063 Escherichia coli 55989 Insertion element IS1 1/5/6 protein insB YP_002404053.1 3132146 D 585055 CDS YP_002404054.1 218696387 7145596 complement(3135358..3136698) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233700, 9772162, 10762278, 13971911; Product type e : enzyme; (D)-glucarate dehydratase 1 3136698 gudD 7145596 gudD Escherichia coli 55989 (D)-glucarate dehydratase 1 YP_002404054.1 3135358 R 585055 CDS YP_002404055.1 218696388 7146385 complement(3138061..3139413) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278; Product type pt : transporter; D-glucarate transporter 3139413 gudP 7146385 gudP Escherichia coli 55989 D-glucarate transporter YP_002404055.1 3138061 R 585055 CDS YP_002404056.1 218696389 7146383 complement(3139848..3140297) 1 NC_011748.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 3140297 yqcA 7146383 yqcA Escherichia coli 55989 flavodoxin YP_002404056.1 3139848 R 585055 CDS YP_002404057.1 218696390 7149393 complement(3140315..3141097) 1 NC_011748.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C 3141097 truC 7149393 truC Escherichia coli 55989 tRNA pseudouridine synthase C YP_002404057.1 3140315 R 585055 CDS YP_002404058.1 218696391 7147860 complement(3141097..3141426) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3141426 yqcC 7147860 yqcC Escherichia coli 55989 hypothetical protein YP_002404058.1 3141097 R 585055 CDS YP_002404059.1 218696392 7145784 complement(3142048..3142593) 1 NC_011748.1 SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd 3142593 syd 7145784 syd Escherichia coli 55989 SecY interacting protein Syd YP_002404059.1 3142048 R 585055 CDS YP_002404060.1 218696393 7147742 3142661..3143509 1 NC_011748.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3143509 queF 7147742 queF Escherichia coli 55989 7-cyano-7-deazaguanine reductase YP_002404060.1 3142661 D 585055 CDS YP_002404061.1 218696394 7147333 3143621..3144985 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3144985 ygdH 7147333 ygdH Escherichia coli 55989 hypothetical protein YP_002404061.1 3143621 D 585055 CDS YP_002404062.1 218696395 7148824 3145542..3146831 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8752353, 8026499; Product type pt : transporter; serine transporter 3146831 sdaC 7148824 sdaC Escherichia coli 55989 serine transporter YP_002404062.1 3145542 D 585055 CDS YP_002404063.1 218696396 7147614 3146889..3148256 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193203, 93215657, 8385012; Product type e : enzyme; L-serine deaminase II 3148256 sdaB 7147614 sdaB Escherichia coli 55989 L-serine deaminase II YP_002404063.1 3146889 D 585055 CDS YP_002404064.1 218696397 7147613 3148278..3149123 1 NC_011748.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 3149123 xni 7147613 xni Escherichia coli 55989 exonuclease IX YP_002404064.1 3148278 D 585055 CDS YP_002404065.1 218696398 7146042 complement(3149178..3150329) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 89291720, 2553671, 2661535, 2664711, 8385012; Product type e : enzyme; L-1,2-propanediol oxidoreductase 3150329 fucO 7146042 fucO Escherichia coli 55989 L-1,2-propanediol oxidoreductase YP_002404065.1 3149178 R 585055 CDS YP_002404066.1 218696399 7146226 complement(3150354..3151001) 1 NC_011748.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase 3151001 fucA 7146226 fucA Escherichia coli 55989 L-fuculose phosphate aldolase YP_002404066.1 3150354 R 585055 CDS YP_002404067.1 218696400 7146223 3151548..3152864 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2553671, 2664711, 7783647; Product type t : transporter; L-fucose transporter 3152864 fucP 7146223 fucP Escherichia coli 55989 L-fucose transporter YP_002404067.1 3151548 D 585055 CDS YP_002404068.1 218696401 7146227 3152897..3154672 1 NC_011748.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 3154672 fucI 7146227 fucI Escherichia coli 55989 L-fucose isomerase YP_002404068.1 3152897 D 585055 CDS YP_002404069.1 218696402 7146224 3154751..3156199 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2664711, 13905785; Product type e : enzyme; L-fuculokinase 3156199 fucK 7146224 fucK Escherichia coli 55989 L-fuculokinase YP_002404069.1 3154751 D 585055 CDS YP_002404070.1 218696403 7146225 3156201..3156623 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078, 12738765, 80049526, 2664711; Product type e : enzyme; L-fucose mutarotase 3156623 fucU 7146225 fucU Escherichia coli 55989 L-fucose mutarotase YP_002404070.1 3156201 D 585055 CDS YP_002404071.1 218696404 7146229 3156681..3157412 1 NC_011748.1 regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 3157412 fucR 7146229 fucR Escherichia coli 55989 DNA-binding transcriptional activator FucR YP_002404071.1 3156681 D 585055 CDS YP_002404072.1 218696405 7146228 complement(3157456..3158556) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21188420, 7704273; Product type pe : enzyme; RNA 2'-O-ribose methyltransferase 3158556 ygdE 7146228 ygdE Escherichia coli 55989 RNA 2'-O-ribose methyltransferase YP_002404072.1 3157456 R 585055 CDS YP_002404073.1 218696406 7148823 complement(3158549..3158944) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7704273; Product type pm : membrane component; hypothetical protein 3158944 ygdD 7148823 ygdD Escherichia coli 55989 hypothetical protein YP_002404073.1 3158549 R 585055 CDS YP_002404074.1 218696407 7148822 complement(3158963..3159880) 1 NC_011748.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA 3159880 gcvA 7148822 gcvA Escherichia coli 55989 DNA-binding transcriptional activator GcvA YP_002404074.1 3158963 R 585055 CDS YP_002404075.1 218696408 7146275 complement(3160231..3160458) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3160458 ygdI 7146275 ygdI Escherichia coli 55989 hypothetical protein YP_002404075.1 3160231 R 585055 CDS YP_002404076.1 218696409 7148825 3160650..3161855 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15148362, 9278392, 10739946, 10829016; Product type e : enzyme; cysteine sulfinate desulfinase 3161855 csdA 7148825 csdA Escherichia coli 55989 cysteine sulfinate desulfinase YP_002404076.1 3160650 D 585055 CDS YP_002404077.1 218696410 7145767 3161855..3162298 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; Fe-S metabolism protein (sufE-like) 3162298 ygdK 7145767 ygdK Escherichia coli 55989 Fe-S metabolism protein (sufE-like) YP_002404077.1 3161855 D 585055 CDS YP_002404078.1 218696411 7148826 complement(3162349..3163155) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3163155 ygdL 7148826 ygdL Escherichia coli 55989 hypothetical protein YP_002404078.1 3162349 R 585055 CDS YP_002404079.1 218696412 7148827 complement(3163232..3164329) 1 NC_011748.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A 3164329 mltA 7148827 mltA Escherichia coli 55989 murein transglycosylase A YP_002404079.1 3163232 R 585055 CDS YP_002404080.1 218696413 7145343 complement(3164907..3166160) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12787347, 21348478; Product type e : enzyme; N-acetylmuramoyl-L-alanine amidase 3166160 amiC 7145343 amiC Escherichia coli 55989 N-acetylmuramoyl-L-alanine amidase YP_002404080.1 3164907 R 585055 CDS YP_002404081.1 218696414 7145492 3166392..3167723 1 NC_011748.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3167723 argA 7145492 argA Escherichia coli 55989 N-acetylglutamate synthase YP_002404081.1 3166392 D 585055 CDS YP_002404082.1 218696415 7145524 complement(3167785..3169611) 1 NC_011748.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha 3169611 recD 7145524 recD Escherichia coli 55989 exonuclease V subunit alpha YP_002404082.1 3167785 R 585055 CDS YP_002404083.1 218696416 7147360 complement(3169611..3173153) 1 NC_011748.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta 3173153 recB 7147360 recB Escherichia coli 55989 exonuclease V subunit beta YP_002404083.1 3169611 R 585055 CDS YP_002404084.1 218696417 7147358 complement(3173146..3176034) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193232, 1570301, 3308636, 3534791, 3537960, 8099278; Product type e : enzyme; protease III 3176034 ptr 7147358 ptr Escherichia coli 55989 protease III YP_002404084.1 3173146 R 585055 CDS YP_002404085.1 218696418 7147283 complement(3176210..3179578) 1 NC_011748.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma 3179578 recC 7147283 recC Escherichia coli 55989 exonuclease V subunit gamma YP_002404085.1 3176210 R 585055 CDS YP_002404086.1 218696419 7147359 complement(3179591..3179914) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein 3179914 ppdC 7147359 ppdC Escherichia coli 55989 hypothetical protein YP_002404086.1 3179591 R 585055 CDS YP_002404087.1 218696420 7147224 complement(3179899..3180306) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3180306 ygdB 7147224 ygdB Escherichia coli 55989 hypothetical protein YP_002404087.1 3179899 R 585055 CDS YP_002404088.1 218696421 7148821 complement(3180303..3180866) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein 3180866 ppdB 7148821 ppdB Escherichia coli 55989 hypothetical protein YP_002404088.1 3180303 R 585055 CDS YP_002404089.1 218696422 7147223 complement(3180857..3181327) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein 3181327 ppdA 7147223 ppdA Escherichia coli 55989 hypothetical protein YP_002404089.1 3180857 R 585055 CDS YP_002404090.1 218696423 7147222 complement(3181512..3182306) 1 NC_011748.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase 3182306 thyA 7147222 thyA Escherichia coli 55989 thymidylate synthase YP_002404090.1 3181512 R 585055 CDS YP_002404091.1 218696424 7147799 complement(3182313..3183188) 1 NC_011748.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase 3183188 lgt 7147799 lgt Escherichia coli 55989 prolipoprotein diacylglyceryl transferase YP_002404091.1 3182313 R 585055 CDS YP_002404092.1 218696425 7146698 complement(3183339..3185585) 1 NC_011748.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain 3185585 ptsP 7146698 ptsP Escherichia coli 55989 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain YP_002404092.1 3183339 R 585055 CDS YP_002404093.1 218696426 7147291 complement(3185598..3186128) 1 NC_011748.1 hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase 3186128 nudH 7147291 nudH Escherichia coli 55989 dinucleoside polyphosphate hydrolase YP_002404093.1 3185598 R 585055 CDS YP_002404094.1 218696427 7147042 3186813..3187502 1 NC_011748.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3187502 mutH 7147042 mutH Escherichia coli 55989 DNA mismatch repair protein YP_002404094.1 3186813 D 585055 CDS YP_002404095.1 218696428 7146931 3187571..3188284 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3188284 ygdQ 7146931 ygdQ Escherichia coli 55989 inner membrane protein YP_002404095.1 3187571 D 585055 CDS YP_002404096.1 218696429 7148828 3188422..3188640 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3188640 ygdR 7148828 ygdR Escherichia coli 55989 hypothetical protein YP_002404096.1 3188422 D 585055 CDS YP_002404097.1 218696430 7148829 3188748..3189788 1 NC_011748.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; aldo-keto reductase 3189788 tas 7148829 tas Escherichia coli 55989 aldo-keto reductase YP_002404097.1 3188748 D 585055 CDS YP_002404098.1 218696431 7147752 complement(3189820..3191013) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8300626; Product type pm : membrane component; lysophospholipid transporter LplT 3191013 ygeD 7147752 ygeD Escherichia coli 55989 lysophospholipid transporter LplT YP_002404098.1 3189820 R 585055 CDS YP_002404099.1 218696432 7148831 complement(3191006..3193165) 1 NC_011748.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase 3193165 aas 7148831 aas Escherichia coli 55989 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase YP_002404099.1 3191006 R 585055 CDS YP_002404100.1 218696433 7147074 3193751..3194782 1 NC_011748.1 controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3194782 galR 7147074 galR Escherichia coli 55989 DNA-binding transcriptional regulator GalR YP_002404100.1 3193751 D 585055 CDS YP_002404101.1 218696434 7146252 complement(3194789..3196051) 1 NC_011748.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase 3196051 lysA 7146252 lysA Escherichia coli 55989 diaminopimelate decarboxylase YP_002404101.1 3194789 R 585055 CDS YP_002404102.1 218696435 7146755 3196173..3197108 1 NC_011748.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; DNA-binding transcriptional regulator LysR 3197108 lysR 7146755 lysR Escherichia coli 55989 DNA-binding transcriptional regulator LysR YP_002404102.1 3196173 D 585055 CDS YP_002404103.1 218696436 7146758 complement(3197095..3197787) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15135544; Product type pe : enzyme; racemase 3197787 ygeA 7146758 ygeA Escherichia coli 55989 racemase YP_002404103.1 3197095 R 585055 CDS YP_002404104.1 218696437 7148830 complement(3197916..3199334) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7030324, 90239116, 91154204, 2836407, 3543693, 6319708; Product type t : transporter; arabinose transporter 3199334 araE 7148830 araE Escherichia coli 55989 arabinose transporter YP_002404104.1 3197916 R 585055 CDS YP_002404105.1 218696438 7145517 complement(3199649..3200410) 1 NC_011748.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase 3200410 kduD 7145517 kduD Escherichia coli 55989 2-deoxy-D-gluconate 3-dehydrogenase YP_002404105.1 3199649 R 585055 CDS YP_002404106.1 218696439 7146664 complement(3200440..3201276) 1 NC_011748.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase 3201276 kduI 7146664 kduI Escherichia coli 55989 5-keto-4-deoxyuronate isomerase YP_002404106.1 3200440 R 585055 CDS YP_002404107.1 218696440 7146665 complement(3201563..3202744) 1 NC_011748.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase 3202744 yqeF 7146665 yqeF Escherichia coli 55989 acetyl-CoA acetyltransferase YP_002404107.1 3201563 R 585055 CDS YP_002404108.1 218696441 7149399 3202999..3204228 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 3204228 yqeG 7149399 yqeG Escherichia coli 55989 transporter YP_002404108.1 3202999 D 585055 CDS YP_002404109.1 218696442 7149400 3204688..3205320 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; bipartite regulator domain 3205320 yqeH 7149400 yqeH Escherichia coli 55989 bipartite regulator domain YP_002404109.1 3204688 D 585055 CDS YP_002404110.1 218696443 7149401 3205654..3206463 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 3206463 yqeI 7149401 yqeI Escherichia coli 55989 transcriptional regulator YP_002404110.1 3205654 D 585055 CDS YP_002404111.1 218696444 7149402 3206456..3206938 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3206938 yqeJ 7149402 yqeJ Escherichia coli 55989 hypothetical protein YP_002404111.1 3206456 D 585055 CDS YP_002404112.1 218696445 7149403 complement(3207087..3207512) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3207512 yqeK 7149403 yqeK Escherichia coli 55989 hypothetical protein YP_002404112.1 3207087 R 585055 CDS YP_002404113.1 218696446 7149404 3207706..3208143 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3208143 ygeF 7149404 ygeF Escherichia coli 55989 hypothetical protein YP_002404113.1 3207706 D 585055 CDS YP_002404114.1 218696447 7148832 3208421..3208912 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; chaperone 3208912 ygeG 7148832 ygeG Escherichia coli 55989 chaperone YP_002404114.1 3208421 D 585055 CDS YP_002404115.1 218696448 7148833 3209247..3210623 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15150243; Product type pr : regulator; transcriptional regulator 3210623 ygeH 7148833 ygeH Escherichia coli 55989 transcriptional regulator YP_002404115.1 3209247 D 585055 CDS YP_002404116.1 218696449 7148834 3210791..3211009 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3211009 ygeI 7148834 ygeI Escherichia coli 55989 hypothetical protein YP_002404116.1 3210791 D 585055 CDS YP_002404117.1 218696450 7148835 3211092..3211568 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; peptidoglycan-binding-like protein precursor 3211568 7148835 EC55989_3132 Escherichia coli 55989 peptidoglycan-binding-like protein precursor YP_002404117.1 3211092 D 585055 CDS YP_002404118.1 218696451 7144867 complement(3212466..3212897) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3212897 ygeM 7144867 ygeM Escherichia coli 55989 hypothetical protein YP_002404118.1 3212466 R 585055 CDS YP_002404119.1 218696452 7148836 complement(3213114..3213695) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847; hypothetical protein 3213695 7148836 EC55989_3136 Escherichia coli 55989 hypothetical protein YP_002404119.1 3213114 R 585055 CDS YP_002404120.1 218696453 7144868 complement(3213711..3214445) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pm : membrane component; Type III secretion system lipoprotein EprK 3214445 eprK 7144868 eprK Escherichia coli 55989 Type III secretion system lipoprotein EprK YP_002404120.1 3213711 R 585055 CDS YP_002404121.1 218696454 7144869 complement(3214878..3215033) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pt : transporter; Type III secretion EprI protein 3215033 eprI 7144869 eprI Escherichia coli 55989 Type III secretion EprI protein YP_002404121.1 3214878 R 585055 CDS YP_002404122.1 218696455 7146013 complement(3215047..3216237) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; Type III secretion EprH protein 3216237 eprH 7146013 eprH Escherichia coli 55989 Type III secretion EprH protein YP_002404122.1 3215047 R 585055 CDS YP_002404123.1 218696456 7146012 3216486..3216986 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847; response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain 3216986 7146012 EC55989_3141 Escherichia coli 55989 response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain YP_002404123.1 3216486 D 585055 CDS YP_002404124.1 218696457 7144870 3216988..3217281 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847; hypothetical protein 3217281 7144870 EC55989_3142 Escherichia coli 55989 hypothetical protein YP_002404124.1 3216988 D 585055 CDS YP_002404125.1 218696458 7147684 complement(3218508..3219275) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pm : membrane component; Type III secretion protein EpaR 3219275 7147684 EC55989_3146 Escherichia coli 55989 Type III secretion protein EpaR YP_002404125.1 3218508 R 585055 CDS YP_002404126.1 218696459 7147681 complement(3219547..3220212) 1 NC_011748.1 part of a type III secretory system probably involved in invasion into eukaryotic cells; surface presentation of antigens protein SpaP 3220212 spaP 7147681 spaP Escherichia coli 55989 surface presentation of antigens protein SpaP YP_002404126.1 3219547 R 585055 CDS YP_002404127.1 218696460 7146010 complement(3221281..3222933) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3222933 7146010 EC55989_3151 Escherichia coli 55989 hypothetical protein YP_002404127.1 3221281 R 585055 CDS YP_002404128.1 218696461 7145379 complement(3223277..3224032) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15150243; Product type r : regulator; Tetratricopeptide repeat transcriptional regulator 3224032 ygeR 7145379 ygeR Escherichia coli 55989 Tetratricopeptide repeat transcriptional regulator YP_002404128.1 3223277 R 585055 CDS YP_002404129.1 218696462 7148837 3224486..3226744 1 NC_011748.1 molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3226744 xdhA 7148837 xdhA Escherichia coli 55989 xanthine dehydrogenase subunit XdhA YP_002404129.1 3224486 D 585055 CDS YP_002404130.1 218696463 7147985 3226755..3227633 1 NC_011748.1 FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3227633 xdhB 7147985 xdhB Escherichia coli 55989 xanthine dehydrogenase subunit XdhB YP_002404130.1 3226755 D 585055 CDS YP_002404131.1 218696464 7147986 3227630..3228109 1 NC_011748.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3228109 xdhC 7147986 xdhC Escherichia coli 55989 xanthine dehydrogenase subunit XdhC YP_002404131.1 3227630 D 585055 CDS YP_002404132.1 218696465 7147987 complement(3228149..3229927) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 3229927 ygeV 7147987 ygeV Escherichia coli 55989 DNA-binding transcriptional regulator YP_002404132.1 3228149 R 585055 CDS YP_002404133.1 218696466 7148838 3230403..3231593 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; aspartate/ornithine carbamoyltransferase 3231593 ygeW 7148838 ygeW Escherichia coli 55989 aspartate/ornithine carbamoyltransferase YP_002404133.1 3230403 D 585055 CDS YP_002404134.1 218696467 7148839 3231651..3232847 1 NC_011748.1 catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3232847 ygeX 7148839 ygeX Escherichia coli 55989 diaminopropionate ammonia-lyase YP_002404134.1 3231651 D 585055 CDS YP_002404135.1 218696468 7148840 3232905..3234116 1 NC_011748.1 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3234116 ygeY 7148840 ygeY Escherichia coli 55989 peptidase YP_002404135.1 3232905 D 585055 CDS YP_002404136.1 218696469 7148841 3234169..3235554 1 NC_011748.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3235554 hyuA 7148841 hyuA Escherichia coli 55989 phenylhydantoinase YP_002404136.1 3234169 D 585055 CDS YP_002404137.1 218696470 7146526 3235602..3236534 1 NC_011748.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3236534 yqeA 7146526 yqeA Escherichia coli 55989 carbamate kinase YP_002404137.1 3235602 D 585055 CDS YP_002404138.1 218696471 7149396 complement(3236575..3238200) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; NAD(P)-binding Rossman fold 3238200 yqeB 7149396 yqeB Escherichia coli 55989 NAD(P)-binding Rossman fold YP_002404138.1 3236575 R 585055 CDS YP_002404139.1 218696472 7149397 complement(3238248..3239018) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3239018 yqeC 7149397 yqeC Escherichia coli 55989 hypothetical protein YP_002404139.1 3238248 R 585055 CDS YP_002404140.1 218696473 7149398 3239121..3239699 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3239699 ygfJ 7149398 ygfJ Escherichia coli 55989 hypothetical protein YP_002404140.1 3239121 D 585055 CDS YP_002404141.1 218696474 7148848 3240021..3243119 1 NC_011748.1 with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; selenate reductase subunit YgfK 3243119 ygfK 7148848 ygfK Escherichia coli 55989 selenate reductase subunit YgfK YP_002404141.1 3240021 D 585055 CDS YP_002404142.1 218696475 7148849 3243122..3244450 1 NC_011748.1 in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; chlorohydrolase/aminohydrolase 3244450 ssnA 7148849 ssnA Escherichia coli 55989 chlorohydrolase/aminohydrolase YP_002404142.1 3243122 D 585055 CDS YP_002404143.1 218696476 7147713 3244501..3245280 1 NC_011748.1 with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; selenate reductase subunit YgfM 3245280 ygfM 7147713 ygfM Escherichia coli 55989 selenate reductase subunit YgfM YP_002404143.1 3244501 D 585055 CDS YP_002404144.1 218696477 7148850 3245277..3248147 1 NC_011748.1 with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; selenate reductase subunit YgfN 3248147 xdhD 7148850 xdhD Escherichia coli 55989 selenate reductase subunit YgfN YP_002404144.1 3245277 D 585055 CDS YP_002404145.1 218696478 7147988 3248312..3249712 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20372655, 98213740; Product type pt : transporter; transporter 3249712 ygfO 7147988 ygfO Escherichia coli 55989 transporter YP_002404145.1 3248312 D 585055 CDS YP_002404146.1 218696479 7148851 3249727..3251046 1 NC_011748.1 Catalyzes the deamination of guanine; guanine deaminase 3251046 guaD 7148851 guaD Escherichia coli 55989 guanine deaminase YP_002404146.1 3249727 D 585055 CDS YP_002404147.1 218696480 7146381 3251082..3252449 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 3252449 ygfQ 7146381 ygfQ Escherichia coli 55989 transporter YP_002404147.1 3251082 D 585055 CDS YP_002404148.1 218696481 7148852 complement(3252485..3252973) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; oxidoreductase, 4Fe-4S ferredoxin-type subunit 3252973 ygfS 7148852 ygfS Escherichia coli 55989 oxidoreductase, 4Fe-4S ferredoxin-type subunit YP_002404148.1 3252485 R 585055 CDS YP_002404149.1 218696482 7148853 complement(3252973..3254892) 1 NC_011748.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit 3254892 ygfT 7148853 ygfT Escherichia coli 55989 oxidoreductase Fe-S binding subunit YP_002404149.1 3252973 R 585055 CDS YP_002404150.1 218696483 7148854 3255328..3256776 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9098051; Product type t : transporter; transporter 3256776 ygfU 7148854 ygfU Escherichia coli 55989 transporter YP_002404150.1 3255328 D 585055 CDS YP_002404151.1 218696484 7148855 3257026..3257574 1 NC_011748.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3257574 idi 7148855 idi Escherichia coli 55989 isopentenyl-diphosphate delta-isomerase YP_002404151.1 3257026 D 585055 CDS YP_002404152.1 218696485 7146539 complement(3257617..3259134) 1 NC_011748.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 3259134 lysS 7146539 lysS Escherichia coli 55989 lysyl-tRNA synthetase YP_002404152.1 3257617 R 585055 CDS YP_002404153.1 218696486 7146759 complement(join(3259144..3260166,3260168..3260242)) 1 NC_011748.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 3260242 prfB 7146759 prfB Escherichia coli 55989 peptide chain release factor 2 YP_002404153.1 3259144 R 585055 CDS YP_002404154.1 218696487 7147241 complement(3260333..3262066) 1 NC_011748.1 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ 3262066 recJ 7147241 recJ Escherichia coli 55989 ssDNA exonuclease RecJ YP_002404154.1 3260333 R 585055 CDS YP_002404155.1 218696488 7147363 complement(3262072..3262782) 1 NC_011748.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC 3262782 dsbC 7147363 dsbC Escherichia coli 55989 thiol:disulfide interchange protein DsbC YP_002404155.1 3262072 R 585055 CDS YP_002404156.1 218696489 7145952 complement(3262807..3263703) 1 NC_011748.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD 3263703 xerD 7145952 xerD Escherichia coli 55989 site-specific tyrosine recombinase XerD YP_002404156.1 3262807 R 585055 CDS YP_002404157.1 218696490 7147990 3263815..3264336 1 NC_011748.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3264336 fldB 7147990 fldB Escherichia coli 55989 flavodoxin FldB YP_002404157.1 3263815 D 585055 CDS YP_002404158.1 218696491 7146123 complement(3264376..3264783) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3264783 ygfX 7146123 ygfX Escherichia coli 55989 hypothetical protein YP_002404158.1 3264376 R 585055 CDS YP_002404159.1 218696492 7148856 complement(3264764..3265030) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3265030 ygfY 7148856 ygfY Escherichia coli 55989 hypothetical protein YP_002404159.1 3264764 R 585055 CDS YP_002404160.1 218696493 7148857 3265273..3266253 1 NC_011748.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; global regulator 3266253 ygfZ 7148857 ygfZ Escherichia coli 55989 global regulator YP_002404160.1 3265273 D 585055 CDS YP_002404161.1 218696494 7148858 3266506..3267486 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 3267486 7148858 EC55989_3185 Escherichia coli 55989 transposase, IS110 family YP_002404161.1 3266506 D 585055 CDS YP_002404162.1 218696495 7144875 complement(3267609..3268268) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; hemolysin, inner membrane subunit 3268268 yqfA 7144875 yqfA Escherichia coli 55989 hemolysin, inner membrane subunit YP_002404162.1 3267609 R 585055 CDS YP_002404163.1 218696496 7149405 complement(3268432..3268743) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3268743 yqfB 7149405 yqfB Escherichia coli 55989 hypothetical protein YP_002404163.1 3268432 R 585055 CDS YP_002404164.1 218696497 7149406 3268782..3270221 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140; Product type e : enzyme; 6-phospho-beta-glucosidase 3270221 bglA 7149406 bglA Escherichia coli 55989 6-phospho-beta-glucosidase YP_002404164.1 3268782 D 585055 CDS YP_002404165.1 218696498 7145616 complement(3270278..3271021) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 3271021 ygfF 7145616 ygfF Escherichia coli 55989 hypothetical protein YP_002404165.1 3270278 R 585055 CDS YP_002404166.1 218696499 7148844 complement(3271282..3274155) 1 NC_011748.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase 3274155 gcvP 7148844 gcvP Escherichia coli 55989 glycine dehydrogenase YP_002404166.1 3271282 R 585055 CDS YP_002404167.1 218696500 7146277 complement(3274274..3274663) 1 NC_011748.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H 3274663 gcvH 7146277 gcvH Escherichia coli 55989 glycine cleavage system protein H YP_002404167.1 3274274 R 585055 CDS YP_002404168.1 218696501 7146276 complement(3274687..3275781) 1 NC_011748.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T 3275781 gcvT 7146276 gcvT Escherichia coli 55989 glycine cleavage system aminomethyltransferase T YP_002404168.1 3274687 R 585055 CDS YP_002404169.1 218696502 7146279 complement(3276229..3277431) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1339425; Product type pe : enzyme; hypothetical protein 3277431 visC 7146279 visC Escherichia coli 55989 hypothetical protein YP_002404169.1 3276229 R 585055 CDS YP_002404170.1 218696503 7147948 complement(3277454..3278632) 1 NC_011748.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase 3278632 ubiH 7147948 ubiH Escherichia coli 55989 2-octaprenyl-6-methoxyphenyl hydroxylase YP_002404170.1 3277454 R 585055 CDS YP_002404171.1 218696504 7147894 complement(3278629..3279954) 1 NC_011748.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II 3279954 pepP 7147894 pepP Escherichia coli 55989 proline aminopeptidase P II YP_002404171.1 3278629 R 585055 CDS YP_002404172.1 218696505 7147135 complement(3279980..3280558) 1 NC_011748.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein 3280558 ygfB 7147135 ygfB Escherichia coli 55989 hypothetical protein YP_002404172.1 3279980 R 585055 CDS YP_002404173.1 218696506 7148843 3280726..3281055 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 412171; Product type cp : cell process; Z-ring-associated protein 3281055 zapA 7148843 zapA Escherichia coli 55989 Z-ring-associated protein YP_002404173.1 3280726 D 585055 CDS YP_002404174.1 218696507 7147717 3281355..3281903 1 NC_011748.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; ligase 3281903 ygfA 7147717 ygfA Escherichia coli 55989 ligase YP_002404174.1 3281355 D 585055 CDS YP_002404175.1 218696508 7147589 complement(3282684..3283916) 1 NC_011748.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase 3283916 serA 7147589 serA Escherichia coli 55989 D-3-phosphoglycerate dehydrogenase YP_002404175.1 3282684 R 585055 CDS YP_002404176.1 218696509 7147632 complement(3284172..3284831) 1 NC_011748.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A 3284831 rpiA 7147632 rpiA Escherichia coli 55989 ribose-5-phosphate isomerase A YP_002404176.1 3284172 R 585055 CDS YP_002404177.1 218696510 7147462 3285214..3286107 1 NC_011748.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3286107 argP 7147462 argP Escherichia coli 55989 chromosome replication initiation inhibitor protein YP_002404177.1 3285214 D 585055 CDS YP_002404178.1 218696511 7149262 3288448..3289443 1 NC_011748.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3289443 argK 7149262 argK Escherichia coli 55989 arginine/ornithine transport system ATPase YP_002404178.1 3288448 D 585055 CDS YP_002404179.1 218696512 7145532 3289454..3290239 1 NC_011748.1 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3290239 ygfG 7145532 ygfG Escherichia coli 55989 methylmalonyl-CoA decarboxylase YP_002404179.1 3289454 D 585055 CDS YP_002404180.1 218696513 7148845 3290263..3291741 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233703; Product type e : enzyme; propionyl-CoA:succinate-CoA transferase 3291741 ygfH 7148845 ygfH Escherichia coli 55989 propionyl-CoA:succinate-CoA transferase YP_002404180.1 3290263 D 585055 CDS YP_002404181.1 218696514 7148846 complement(3291738..3292634) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 3292634 ygfI 7148846 ygfI Escherichia coli 55989 DNA-binding transcriptional regulator YP_002404181.1 3291738 R 585055 CDS YP_002404182.1 218696515 7148847 complement(3292801..3293541) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3293541 yggE 7148847 yggE Escherichia coli 55989 hypothetical protein YP_002404182.1 3292801 R 585055 CDS YP_002404183.1 218696516 7148861 complement(3293634..3294269) 1 NC_011748.1 Involved in the export of arginine; arginine exporter protein 3294269 argO 7148861 argO Escherichia coli 55989 arginine exporter protein YP_002404183.1 3293634 R 585055 CDS YP_002404184.1 218696517 7145533 complement(3294408..3295268) 1 NC_011748.1 participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS 3295268 mscS 7145533 mscS Escherichia coli 55989 mechanosensitive channel MscS YP_002404184.1 3294408 R 585055 CDS YP_002404185.1 218696518 7146909 complement(3295626..3296705) 1 NC_011748.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase 3296705 fbaA 7146909 fbaA Escherichia coli 55989 fructose-bisphosphate aldolase YP_002404185.1 3295626 R 585055 CDS YP_002404186.1 218696519 7146062 complement(3296920..3298083) 1 NC_011748.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase 3298083 pgk 7146062 pgk Escherichia coli 55989 phosphoglycerate kinase YP_002404186.1 3296920 R 585055 CDS YP_002404187.1 218696520 7147151 complement(3298133..3299152) 1 NC_011748.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase 3299152 epd 7147151 epd Escherichia coli 55989 erythrose 4-phosphate dehydrogenase YP_002404187.1 3298133 R 585055 CDS YP_002404188.1 218696521 7146011 3299524..3299955 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; DNA-binding protein 3299955 7146011 EC55989_3216 Escherichia coli 55989 DNA-binding protein YP_002404188.1 3299524 D 585055 CDS YP_002404189.1 218696522 7144876 3299879..3300556 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; ABC-type transport system 3300556 7144876 EC55989_3217 Escherichia coli 55989 ABC-type transport system YP_002404189.1 3299879 D 585055 CDS YP_002404190.1 218696523 7144877 3300557..3301264 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; ABC-type transport system 3301264 7144877 EC55989_3218 Escherichia coli 55989 ABC-type transport system YP_002404190.1 3300557 D 585055 CDS YP_002404191.1 218696524 7144878 3301246..3301929 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; ABC transporter ATP-binding protein 3301929 7144878 EC55989_3219 Escherichia coli 55989 ABC transporter ATP-binding protein YP_002404191.1 3301246 D 585055 CDS YP_002404192.1 218696525 7144879 3301890..3302600 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; ABC transporter ATP-binding protein 3302600 7144879 EC55989_3220 Escherichia coli 55989 ABC transporter ATP-binding protein YP_002404192.1 3301890 D 585055 CDS YP_002404193.1 218696526 7144880 complement(3302572..3303285) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; fructose transport system kinase 3303285 frcK 7144880 frcK Escherichia coli 55989 fructose transport system kinase YP_002404193.1 3302572 R 585055 CDS YP_002404194.1 218696527 7148859 complement(3303282..3303791) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 3303791 yggD 7148859 yggD Escherichia coli 55989 DNA-binding transcriptional regulator YP_002404194.1 3303282 R 585055 CDS YP_002404195.1 218696528 7148860 complement(3303813..3304778) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; fructose-1,6-bisphosphatase II-like protein 3304778 yggF 7148860 yggF Escherichia coli 55989 fructose-1,6-bisphosphatase II-like protein YP_002404195.1 3303813 R 585055 CDS YP_002404196.1 218696529 7148862 complement(3304775..3306052) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; dehydrogenase 3306052 yggP 7148862 yggP Escherichia coli 55989 dehydrogenase YP_002404196.1 3304775 R 585055 CDS YP_002404197.1 218696530 7148869 complement(3306067..3307455) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8353127; Product type t : transporter; fused mannitol-specific PTS enzymes: IIB component ; IIC component 3307455 cmtA 7148869 cmtA Escherichia coli 55989 fused mannitol-specific PTS enzymes: IIB component ; IIC component YP_002404197.1 3306067 R 585055 CDS YP_002404198.1 218696531 7145730 complement(3307483..3307926) 1 NC_011748.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; mannitol phosphotransferase subunit EIIA 3307926 cmtB 7145730 cmtB Escherichia coli 55989 mannitol phosphotransferase subunit EIIA YP_002404198.1 3307483 R 585055 CDS YP_002404199.1 218696532 7145731 complement(3308240..3310231) 1 NC_011748.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 3310231 tktA 7145731 tktA Escherichia coli 55989 transketolase YP_002404199.1 3308240 R 585055 CDS YP_002404200.1 218696533 7147804 3310509..3311267 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1310091; Product type pe : enzyme; peptidase 3311267 yggG 7147804 yggG Escherichia coli 55989 peptidase YP_002404200.1 3310509 D 585055 CDS YP_002404201.1 218696534 7148863 complement(3311473..3312393) 1 NC_011748.1 catalyzes the formation of putrescine from agmatine; agmatinase 3312393 speB 7148863 speB Escherichia coli 55989 agmatinase YP_002404201.1 3311473 R 585055 CDS YP_002404202.1 218696535 7147686 complement(3312529..3313260) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3313260 7147686 EC55989_3230 Escherichia coli 55989 hypothetical protein YP_002404202.1 3312529 R 585055 CDS YP_002404203.1 218696536 7144881 complement(3313406..3315382) 1 NC_011748.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase 3315382 speA 7144881 speA Escherichia coli 55989 arginine decarboxylase YP_002404203.1 3313406 R 585055 CDS YP_002404204.1 218696537 7147685 complement(3315391..3315537) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3315537 yqgB 7147685 yqgB Escherichia coli 55989 hypothetical protein YP_002404204.1 3315391 R 585055 CDS YP_002404205.1 218696538 7149408 3315658..3315873 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3315873 yqgC 7149408 yqgC Escherichia coli 55989 hypothetical protein YP_002404205.1 3315658 D 585055 CDS YP_002404206.1 218696539 7149409 complement(3315870..3316121) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3316121 yqgD 7149409 yqgD Escherichia coli 55989 inner membrane protein YP_002404206.1 3315870 R 585055 CDS YP_002404207.1 218696540 7149410 3316177..3317331 1 NC_011748.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3317331 metK 7149410 metK Escherichia coli 55989 S-adenosylmethionine synthetase YP_002404207.1 3316177 D 585055 CDS YP_002404208.1 218696541 7146833 3317767..3319161 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9182541; Product type t : transporter; D-galactose transporter 3319161 galP 7146833 galP Escherichia coli 55989 D-galactose transporter YP_002404208.1 3317767 D 585055 CDS YP_002404209.1 218696542 7146251 3319238..3319735 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7984428, 8113204; hypothetical protein 3319735 sprT 7146251 sprT Escherichia coli 55989 hypothetical protein YP_002404209.1 3319238 D 585055 CDS YP_002404210.1 218696543 7147696 3319830..3320537 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 72060411, 92335461, 4955462, 7867949, 8113204; Product type e : enzyme; DNA-specific endonuclease I 3320537 endA 7147696 endA Escherichia coli 55989 DNA-specific endonuclease I YP_002404210.1 3319830 D 585055 CDS YP_002404211.1 218696544 7145997 3320617..3321348 1 NC_011748.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3321348 yggJ 7145997 yggJ Escherichia coli 55989 16S ribosomal RNA methyltransferase RsmE YP_002404211.1 3320617 D 585055 CDS YP_002404212.1 218696545 7148865 3321361..3322311 1 NC_011748.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3322311 gshB 7148865 gshB Escherichia coli 55989 glutathione synthetase YP_002404212.1 3321361 D 585055 CDS YP_002404213.1 218696546 7146374 3322420..3322983 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3322983 yqgE 7146374 yqgE Escherichia coli 55989 hypothetical protein YP_002404213.1 3322420 D 585055 CDS YP_002404214.1 218696547 7149411 3322983..3323399 1 NC_011748.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3323399 yqgF 7149411 yqgF Escherichia coli 55989 Holliday junction resolvase-like protein YP_002404214.1 3322983 D 585055 CDS YP_002404215.1 218696548 7149412 complement(3323575..3324555) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1676385; Product type t : transporter; transporter 3324555 yggR 7149412 yggR Escherichia coli 55989 transporter YP_002404215.1 3323575 R 585055 CDS YP_002404216.1 218696549 7148870 3324573..3325277 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 3325277 yggS 7148870 yggS Escherichia coli 55989 hypothetical protein YP_002404216.1 3324573 D 585055 CDS YP_002404217.1 218696550 7148871 3325295..3325861 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3325861 yggT 7148871 yggT Escherichia coli 55989 inner membrane protein YP_002404217.1 3325295 D 585055 CDS YP_002404218.1 218696551 7148872 3325858..3326148 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12975589; hypothetical protein 3326148 yggU 7148872 yggU Escherichia coli 55989 hypothetical protein YP_002404218.1 3325858 D 585055 CDS YP_002404219.1 218696552 7148873 3326156..3326749 1 NC_011748.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 3326749 yggV 7148873 yggV Escherichia coli 55989 deoxyribonucleotide triphosphate pyrophosphatase YP_002404219.1 3326156 D 585055 CDS YP_002404220.1 218696553 7148874 3326742..3327878 1 NC_011748.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3327878 yggW 7148874 yggW Escherichia coli 55989 coproporphyrinogen III oxidase YP_002404220.1 3326742 D 585055 CDS YP_002404221.1 218696554 7148875 complement(3328033..3329040) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3329040 yggM 7148875 yggM Escherichia coli 55989 hypothetical protein YP_002404221.1 3328033 R 585055 CDS YP_002404222.1 218696555 7148867 complement(3329157..3330203) 1 NC_011748.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II 3330203 ansB 7148867 ansB Escherichia coli 55989 L-asparaginase II YP_002404222.1 3329157 R 585055 CDS YP_002404223.1 218696556 7145503 complement(3330379..3331098) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3331098 yggN 7145503 yggN Escherichia coli 55989 hypothetical protein YP_002404223.1 3330379 R 585055 CDS YP_002404224.1 218696557 7148868 complement(3331282..3331608) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3331608 yggL 7148868 yggL Escherichia coli 55989 hypothetical protein YP_002404224.1 3331282 R 585055 CDS YP_002404225.1 218696558 7148866 complement(3331608..3332327) 1 NC_011748.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase 3332327 trmB 7148866 trmB Escherichia coli 55989 tRNA (guanine-N(7)-)-methyltransferase YP_002404225.1 3331608 R 585055 CDS YP_002404226.1 218696559 7148864 3332488..3333540 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14730969, 20187555, 20316830, 20580749, 21438845, 90046892, 92409600, 9801309, 2001994, 2197596, 9846876; Product type e : enzyme; adenine DNA glycosylase 3333540 mutY 7148864 mutY Escherichia coli 55989 adenine DNA glycosylase YP_002404226.1 3332488 D 585055 CDS YP_002404227.1 218696560 7146936 3333568..3333843 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594836, 10493123, 9298646, 9868784; Product type f : factor; hypothetical protein 3333843 yggX 7146936 yggX Escherichia coli 55989 hypothetical protein YP_002404227.1 3333568 D 585055 CDS YP_002404228.1 218696561 7148876 3333908..3334987 1 NC_011748.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3334987 mltC 7148876 mltC Escherichia coli 55989 murein transglycosylase C YP_002404228.1 3333908 D 585055 CDS YP_002404229.1 218696562 7146865 3335189..3336445 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88029453, 90323001, 3311747; Product type t : transporter; nucleoside transporter 3336445 nupG 7146865 nupG Escherichia coli 55989 nucleoside transporter YP_002404229.1 3335189 D 585055 CDS YP_002404230.1 218696563 7147057 complement(3336495..3338630) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 87260820; Product type e : enzyme; ornithine decarboxylase 3338630 speC 7147057 speC Escherichia coli 55989 ornithine decarboxylase YP_002404230.1 3336495 R 585055 CDS YP_002404231.1 218696564 7147687 3339028..3339735 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3339735 yqgA 7147687 yqgA Escherichia coli 55989 inner membrane protein YP_002404231.1 3339028 D 585055 CDS YP_002404232.1 218696565 7145344 3340114..3341376 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Prophage integrase 3341376 int 7145344 int Escherichia coli 55989 Prophage integrase YP_002404232.1 3340114 D 585055 CDS YP_002404233.1 218696566 7146605 3341854..3342117 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3342117 7146605 EC55989_3261 Escherichia coli 55989 hypothetical protein YP_002404233.1 3341854 D 585055 CDS YP_002404234.1 218696567 7147436 complement(3342583..3343176) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3343176 7147436 EC55989_3262 Escherichia coli 55989 hypothetical protein YP_002404234.1 3342583 R 585055 CDS YP_002404235.1 218696568 7144883 complement(3343104..3343373) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3343373 7144883 EC55989_3263 Escherichia coli 55989 hypothetical protein YP_002404235.1 3343104 R 585055 CDS YP_002404236.1 218696569 7144884 3343569..3346436 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Helicase 3346436 7144884 EC55989_3265 Escherichia coli 55989 Helicase YP_002404236.1 3343569 D 585055 CDS YP_002404237.1 218696570 7144885 3346438..3347442 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; ATPase 3347442 7144885 EC55989_3266 Escherichia coli 55989 ATPase YP_002404237.1 3346438 D 585055 CDS YP_002404238.1 218696571 7144886 3347452..3349839 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; serine protease 3349839 7144886 EC55989_3267 Escherichia coli 55989 serine protease YP_002404238.1 3347452 D 585055 CDS YP_002404239.1 218696572 7144887 3349849..3351477 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; DNA methylase N-4/N-6 3351477 7144887 EC55989_3268 Escherichia coli 55989 DNA methylase N-4/N-6 YP_002404239.1 3349849 D 585055 CDS YP_002404240.1 218696573 7144888 3351480..3354350 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; PstII restriction-modification enzyme Res subunit 3354350 7144888 EC55989_3269 Escherichia coli 55989 PstII restriction-modification enzyme Res subunit YP_002404240.1 3351480 D 585055 CDS YP_002404241.1 218696574 7144889 3354439..3354732 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3354732 7144889 EC55989_3270 Escherichia coli 55989 hypothetical protein YP_002404241.1 3354439 D 585055 CDS YP_002404242.1 218696575 7144890 3354766..3355152 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase ORF A, IS3 family 3355152 7144890 EC55989_3271 Escherichia coli 55989 transposase ORF A, IS3 family YP_002404242.1 3354766 D 585055 CDS YP_002404243.1 218696576 7144891 complement(3355072..3356223) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094, 6092059; Product type e : enzyme; IS30 transposase; KpLE2 phage-like element 3356223 insI 7144891 insI Escherichia coli 55989 IS30 transposase; KpLE2 phage-like element YP_002404243.1 3355072 R 585055 CDS YP_002404244.1 218696577 7147435 3356354..3357505 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase 3357505 7147435 EC55989_3273 Escherichia coli 55989 transposase YP_002404244.1 3356354 D 585055 CDS YP_002404245.1 218696578 7144892 complement(3357615..3359183) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; transposase ORF1, IS66 family 3359183 7144892 EC55989_3274 Escherichia coli 55989 transposase ORF1, IS66 family YP_002404245.1 3357615 R 585055 CDS YP_002404246.1 218696579 7144893 complement(3359214..3359564) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; transposase ORF2, IS66 family 3359564 7144893 EC55989_3275 Escherichia coli 55989 transposase ORF2, IS66 family YP_002404246.1 3359214 R 585055 CDS YP_002404247.1 218696580 7144894 complement(3359561..3359998) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; transposase 3359998 7144894 EC55989_3276 Escherichia coli 55989 transposase YP_002404247.1 3359561 R 585055 CDS YP_002404248.1 218696581 7144896 3360598..3360816 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3360816 7144896 EC55989_3278 Escherichia coli 55989 hypothetical protein YP_002404248.1 3360598 D 585055 CDS YP_002404249.1 218696582 7144897 complement(3360967..3365085) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; Serine protease pic precursor (ShMu) 3365085 7144897 EC55989_3279 Escherichia coli 55989 Serine protease pic precursor (ShMu) YP_002404249.1 3360967 R 585055 CDS YP_002404250.1 218696583 7145310 complement(3366116..3367639) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; reverse transcriptase-like protein from prophage or plasmid 3367639 7145310 EC55989_3281 Escherichia coli 55989 reverse transcriptase-like protein from prophage or plasmid YP_002404250.1 3366116 R 585055 CDS YP_002404251.1 218696584 7144900 complement(3368231..3368803) 1 NC_011748.1 Evidence 7 : Gene remnant; Product type pe : enzyme; transposase ORF B (fragment), IS629 3368803 7144900 EC55989_3282 Escherichia coli 55989 transposase ORF B (fragment), IS629 YP_002404251.1 3368231 R 585055 CDS YP_002404252.1 218696585 7144901 complement(3369231..3371780) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3371780 7144901 EC55989_3283 Escherichia coli 55989 hypothetical protein YP_002404252.1 3369231 R 585055 CDS YP_002404253.1 218696586 7144902 complement(3371784..3375197) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3375197 7144902 EC55989_3284 Escherichia coli 55989 hypothetical protein YP_002404253.1 3371784 R 585055 CDS YP_002404254.1 218696587 7144903 complement(3375194..3375796) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3375796 7144903 EC55989_3285 Escherichia coli 55989 hypothetical protein YP_002404254.1 3375194 R 585055 CDS YP_002404255.1 218696588 7144904 complement(3375781..3376095) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3376095 7144904 EC55989_3286 Escherichia coli 55989 hypothetical protein YP_002404255.1 3375781 R 585055 CDS YP_002404256.1 218696589 7144905 complement(3376123..3377553) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3377553 7144905 EC55989_3287 Escherichia coli 55989 hypothetical protein YP_002404256.1 3376123 R 585055 CDS YP_002404257.1 218696590 7144906 complement(3377554..3378108) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3378108 7144906 EC55989_3288 Escherichia coli 55989 hypothetical protein YP_002404257.1 3377554 R 585055 CDS YP_002404258.1 218696591 7144907 complement(3378113..3379189) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3379189 7144907 EC55989_3289 Escherichia coli 55989 hypothetical protein YP_002404258.1 3378113 R 585055 CDS YP_002404259.1 218696592 7144908 complement(3379193..3379498) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3379498 7144908 EC55989_3290 Escherichia coli 55989 hypothetical protein YP_002404259.1 3379193 R 585055 CDS YP_002404260.1 218696593 7144909 complement(3379502..3379969) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3379969 7144909 EC55989_3291 Escherichia coli 55989 hypothetical protein YP_002404260.1 3379502 R 585055 CDS YP_002404261.1 218696594 7144910 complement(3379980..3381962) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3381962 7144910 EC55989_3292 Escherichia coli 55989 hypothetical protein YP_002404261.1 3379980 R 585055 CDS YP_002404262.1 218696595 7144911 complement(3381975..3382934) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3382934 7144911 EC55989_3293 Escherichia coli 55989 hypothetical protein YP_002404262.1 3381975 R 585055 CDS YP_002404263.1 218696596 7144912 complement(3382898..3384700) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3384700 7144912 EC55989_3294 Escherichia coli 55989 hypothetical protein YP_002404263.1 3382898 R 585055 CDS YP_002404264.1 218696597 7144913 complement(3384693..3385115) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3385115 7144913 EC55989_3295 Escherichia coli 55989 hypothetical protein YP_002404264.1 3384693 R 585055 CDS YP_002404265.1 218696598 7144914 complement(3385125..3385631) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3385631 7144914 EC55989_3296 Escherichia coli 55989 hypothetical protein YP_002404265.1 3385125 R 585055 CDS YP_002404266.1 218696599 7144915 complement(3385641..3387119) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3387119 7144915 EC55989_3297 Escherichia coli 55989 hypothetical protein YP_002404266.1 3385641 R 585055 CDS YP_002404267.1 218696600 7144916 complement(3387122..3387598) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3387598 7144916 EC55989_3298 Escherichia coli 55989 hypothetical protein YP_002404267.1 3387122 R 585055 CDS YP_002404268.1 218696601 7147442 3388044..3389252 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L 3389252 7147442 EC55989_3299 Escherichia coli 55989 transposase, IS4 family, IS10L YP_002404268.1 3388044 D 585055 CDS YP_002404269.1 218696602 7144918 3389332..3389640 1 NC_011748.1 Evidence 7 : Gene remnant; Product type pe : enzyme; transposase (fragment), IS630 family 3389640 7144918 EC55989_3300 Escherichia coli 55989 transposase (fragment), IS630 family YP_002404269.1 3389332 D 585055 CDS YP_002404270.1 218696603 7144919 3389876..3390076 1 NC_011748.1 Evidence 7 : Gene remnant; Product type pe : enzyme; transposase (fragment), IS630 family 3390076 7144919 EC55989_3302 Escherichia coli 55989 transposase (fragment), IS630 family YP_002404270.1 3389876 D 585055 CDS YP_002404271.1 218696604 7144920 3390130..3390348 1 NC_011748.1 Evidence 7 : Gene remnant; Product type pe : enzyme; transposase (fragment), IS630 family 3390348 7144920 EC55989_3303 Escherichia coli 55989 transposase (fragment), IS630 family YP_002404271.1 3390130 D 585055 CDS YP_002404272.1 218696605 7144921 complement(3390457..3390942) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3390942 7144921 EC55989_3305 Escherichia coli 55989 hypothetical protein YP_002404272.1 3390457 R 585055 CDS YP_002404273.1 218696606 7144922 complement(3390836..3391042) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; polyketide synthase pksM (fragment) 3391042 7144922 EC55989_3306 Escherichia coli 55989 polyketide synthase pksM (fragment) YP_002404273.1 3390836 R 585055 CDS YP_002404274.1 218696607 7144923 3391214..3391609 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3391609 7144923 EC55989_3307 Escherichia coli 55989 hypothetical protein YP_002404274.1 3391214 D 585055 CDS YP_002404275.1 218696608 7144924 3391435..3391632 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3391632 7144924 EC55989_3308 Escherichia coli 55989 hypothetical protein YP_002404275.1 3391435 D 585055 CDS YP_002404276.1 218696609 7144925 complement(3391663..3391986) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3391986 7144925 EC55989_3309 Escherichia coli 55989 hypothetical protein YP_002404276.1 3391663 R 585055 CDS YP_002404277.1 218696610 7144926 complement(3392052..3392696) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3392696 7144926 EC55989_3310 Escherichia coli 55989 hypothetical protein YP_002404277.1 3392052 R 585055 CDS YP_002404278.1 218696611 7144927 complement(3392717..3393025) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; transcriptional regulator 3393025 7144927 EC55989_3311 Escherichia coli 55989 transcriptional regulator YP_002404278.1 3392717 R 585055 CDS YP_002404279.1 218696612 7144928 complement(3393065..3393709) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; transcriptional regulator IbrB 3393709 ibrB 7144928 ibrB Escherichia coli 55989 transcriptional regulator IbrB YP_002404279.1 3393065 R 585055 CDS YP_002404280.1 218696613 7146536 complement(3393694..3394926) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator 3394926 ibrA 7146536 ibrA Escherichia coli 55989 immunoglobulin-binding regulator YP_002404280.1 3393694 R 585055 CDS YP_002404281.1 218696614 7146534 complement(3394967..3395797) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3395797 7146534 EC55989_3314 Escherichia coli 55989 hypothetical protein YP_002404281.1 3394967 R 585055 CDS YP_002404282.1 218696615 7144929 complement(3396575..3397942) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3397942 7144929 EC55989_3315 Escherichia coli 55989 hypothetical protein YP_002404282.1 3396575 R 585055 CDS YP_002404283.1 218696616 7144930 complement(3398367..3400154) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; UvrD/REP helicase 3400154 7144930 EC55989_3316 Escherichia coli 55989 UvrD/REP helicase YP_002404283.1 3398367 R 585055 CDS YP_002404284.1 218696617 7144931 complement(3400348..3401514) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3401514 7144931 EC55989_3317 Escherichia coli 55989 hypothetical protein YP_002404284.1 3400348 R 585055 CDS YP_002404285.1 218696618 7144932 complement(3401747..3402160) 1 NC_011748.1 hypothetical protein 3402160 7144932 EC55989_3318 Escherichia coli 55989 hypothetical protein YP_002404285.1 3401747 R 585055 CDS YP_002404286.1 218696619 7144933 complement(3402305..3402739) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3402739 7144933 EC55989_3319 Escherichia coli 55989 hypothetical protein YP_002404286.1 3402305 R 585055 CDS YP_002404287.1 218696620 7144934 complement(3402739..3403275) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3403275 7144934 EC55989_3320 Escherichia coli 55989 hypothetical protein YP_002404287.1 3402739 R 585055 CDS YP_002404288.1 218696621 7144935 complement(3403256..3404356) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3404356 7144935 EC55989_3321 Escherichia coli 55989 hypothetical protein YP_002404288.1 3403256 R 585055 CDS YP_002404289.1 218696622 7144936 complement(3404311..3406074) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3406074 7144936 EC55989_3322 Escherichia coli 55989 hypothetical protein YP_002404289.1 3404311 R 585055 CDS YP_002404290.1 218696623 7144937 complement(3406082..3406879) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3406879 7144937 EC55989_3323 Escherichia coli 55989 hypothetical protein YP_002404290.1 3406082 R 585055 CDS YP_002404291.1 218696624 7144938 complement(3406776..3408374) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3408374 7144938 EC55989_3324 Escherichia coli 55989 hypothetical protein YP_002404291.1 3406776 R 585055 CDS YP_002404292.1 218696625 7144939 complement(3408374..3411763) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3411763 7144939 EC55989_3325 Escherichia coli 55989 hypothetical protein YP_002404292.1 3408374 R 585055 CDS YP_002404293.1 218696626 7144940 complement(3411756..3412904) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3412904 7144940 EC55989_3326 Escherichia coli 55989 hypothetical protein YP_002404293.1 3411756 R 585055 CDS YP_002404294.1 218696627 7144941 complement(3412908..3413174) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3413174 7144941 EC55989_3327 Escherichia coli 55989 hypothetical protein YP_002404294.1 3412908 R 585055 CDS YP_002404295.1 218696628 7144942 complement(3413206..3413883) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3413883 7144942 EC55989_3328 Escherichia coli 55989 hypothetical protein YP_002404295.1 3413206 R 585055 CDS YP_002404296.1 218696629 7144943 complement(3414027..3414704) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3414704 7144943 EC55989_3329 Escherichia coli 55989 hypothetical protein YP_002404296.1 3414027 R 585055 CDS YP_002404297.1 218696630 7144944 complement(3414724..3416406) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3416406 7144944 EC55989_3330 Escherichia coli 55989 hypothetical protein YP_002404297.1 3414724 R 585055 CDS YP_002404298.1 218696631 7144945 complement(3416403..3418928) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3418928 7144945 EC55989_3331 Escherichia coli 55989 hypothetical protein YP_002404298.1 3416403 R 585055 CDS YP_002404299.1 218696632 7144946 complement(3419451..3420026) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3420026 7144946 EC55989_3333 Escherichia coli 55989 hypothetical protein YP_002404299.1 3419451 R 585055 CDS YP_002404300.1 218696633 7144947 complement(3420014..3422680) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; chaperone clpB 3422680 7144947 EC55989_3334 Escherichia coli 55989 chaperone clpB YP_002404300.1 3420014 R 585055 CDS YP_002404301.1 218696634 7144948 complement(3422840..3423331) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3423331 7144948 EC55989_3335 Escherichia coli 55989 hypothetical protein YP_002404301.1 3422840 R 585055 CDS YP_002404302.1 218696635 7144949 complement(3423337..3425163) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3425163 7144949 EC55989_3336 Escherichia coli 55989 hypothetical protein YP_002404302.1 3423337 R 585055 CDS YP_002404303.1 218696636 7144950 complement(3425070..3425789) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3425789 7144950 EC55989_3337 Escherichia coli 55989 hypothetical protein YP_002404303.1 3425070 R 585055 CDS YP_002404304.1 218696637 7144951 complement(3425720..3427057) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3427057 7144951 EC55989_3338 Escherichia coli 55989 hypothetical protein YP_002404304.1 3425720 R 585055 CDS YP_002404305.1 218696638 7144952 complement(3427073..3428617) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3428617 7144952 EC55989_3339 Escherichia coli 55989 hypothetical protein YP_002404305.1 3427073 R 585055 CDS YP_002404306.1 218696639 7144953 complement(3428639..3429160) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3429160 7144953 EC55989_3340 Escherichia coli 55989 hypothetical protein YP_002404306.1 3428639 R 585055 CDS YP_002404307.1 218696640 7144954 3429643..3429834 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3429834 7144954 EC55989_3342 Escherichia coli 55989 hypothetical protein YP_002404307.1 3429643 D 585055 CDS YP_002404308.1 218696641 7144955 complement(3429887..3430195) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3430195 7144955 EC55989_3343 Escherichia coli 55989 hypothetical protein YP_002404308.1 3429887 R 585055 CDS YP_002404309.1 218696642 7144956 complement(3430216..3430875) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3430875 7144956 EC55989_3344 Escherichia coli 55989 hypothetical protein YP_002404309.1 3430216 R 585055 CDS YP_002404310.1 218696643 7144957 complement(3431148..3431621) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3431621 7144957 EC55989_3345 Escherichia coli 55989 hypothetical protein YP_002404310.1 3431148 R 585055 CDS YP_002404311.1 218696644 7144958 complement(3431557..3431946) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3431946 7144958 EC55989_3346 Escherichia coli 55989 hypothetical protein YP_002404311.1 3431557 R 585055 CDS YP_002404312.1 218696645 7144959 complement(3432108..3432677) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3432677 7144959 EC55989_3348 Escherichia coli 55989 hypothetical protein YP_002404312.1 3432108 R 585055 CDS YP_002404313.1 218696646 7144960 3432881..3433054 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3433054 7144960 EC55989_3349 Escherichia coli 55989 hypothetical protein YP_002404313.1 3432881 D 585055 CDS YP_002404314.1 218696647 7144961 complement(3432924..3433127) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3433127 7144961 EC55989_3350 Escherichia coli 55989 hypothetical protein YP_002404314.1 3432924 R 585055 CDS YP_002404315.1 218696648 7144962 complement(3433294..3433506) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1956303, 8145648, 1484495; Product type f : factor; hemolysin expression-modulating protein 3433506 7144962 EC55989_3351 Escherichia coli 55989 hemolysin expression-modulating protein YP_002404315.1 3433294 R 585055 CDS YP_002404316.1 218696649 7144964 3434470..3435069 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3435069 7144964 EC55989_3353 Escherichia coli 55989 hypothetical protein YP_002404316.1 3434470 D 585055 CDS YP_002404317.1 218696650 7144965 complement(3435055..3435291) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3435291 7144965 EC55989_3354 Escherichia coli 55989 hypothetical protein YP_002404317.1 3435055 R 585055 CDS YP_002404318.1 218696651 7144966 3436564..3437583 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3437583 7144966 EC55989_3355 Escherichia coli 55989 hypothetical protein YP_002404318.1 3436564 D 585055 CDS YP_002404319.1 218696652 7144967 3437654..3438565 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; GTPase 3438565 7144967 EC55989_3356 Escherichia coli 55989 GTPase YP_002404319.1 3437654 D 585055 CDS YP_002404320.1 218696653 7146635 3438893..3442018 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20392470, 97257509, 99212225, 2661530, 9298646; Product type h : extrachromosomal origin; antigen 43 (Ag43) phase-variable biofilm formation autotransporter; CP4-44 prophage 3442018 flu 7146635 flu Escherichia coli 55989 antigen 43 (Ag43) phase-variable biofilm formation autotransporter; CP4-44 prophage YP_002404320.1 3438893 D 585055 CDS YP_002404321.1 218696654 7146163 3442133..3444655 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; membrane protein, yeeR 3444655 7146163 EC55989_3358 Escherichia coli 55989 membrane protein, yeeR YP_002404321.1 3442133 D 585055 CDS YP_002404322.1 218696655 7144969 3444731..3445186 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3445186 7144969 EC55989_3359 Escherichia coli 55989 hypothetical protein YP_002404322.1 3444731 D 585055 CDS YP_002404323.1 218696656 7144970 3445265..3445498 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3445498 7144970 EC55989_3360 Escherichia coli 55989 hypothetical protein YP_002404323.1 3445265 D 585055 CDS YP_002404324.1 218696657 7144971 3445598..3446416 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3446416 7144971 EC55989_3361 Escherichia coli 55989 hypothetical protein YP_002404324.1 3445598 D 585055 CDS YP_002404325.1 218696658 7144973 3447237..3447683 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : factor; DNA repair protein; CP4-44 prophage 3447683 yeeS 7144973 yeeS Escherichia coli 55989 DNA repair protein; CP4-44 prophage YP_002404325.1 3447237 D 585055 CDS YP_002404326.1 218696659 7148605 3447770..3447991 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; CP4-44 prophage 3447991 yeeT 7148605 yeeT Escherichia coli 55989 CP4-44 prophage YP_002404326.1 3447770 D 585055 CDS YP_002404327.1 218696660 7148609 3448071..3448448 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; antitoxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 3448448 yeeU 7148609 yeeU Escherichia coli 55989 antitoxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage YP_002404327.1 3448071 D 585055 CDS YP_002404328.1 218696661 7148613 3448390..3448872 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type f : factor; toxin of the YeeV-YeeU toxin-antitoxin system 3448872 yeeV 7148613 yeeV Escherichia coli 55989 toxin of the YeeV-YeeU toxin-antitoxin system YP_002404328.1 3448390 D 585055 CDS YP_002404329.1 218696662 7148617 3448869..3449291 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3449291 yeeW 7148617 yeeW Escherichia coli 55989 hypothetical protein YP_002404329.1 3448869 D 585055 CDS YP_002404330.1 218696663 7148620 3449376..3450218 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9987116; hypothetical protein 3450218 7148620 EC55989_3368 Escherichia coli 55989 hypothetical protein YP_002404330.1 3449376 D 585055 CDS YP_002404331.1 218696664 7144974 complement(3450499..3451035) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; general secretion pathway protein YghD 3451035 yghD 7144974 yghD Escherichia coli 55989 general secretion pathway protein YghD YP_002404331.1 3450499 R 585055 CDS YP_002404332.1 218696665 7148879 complement(3451037..3452215) 1 NC_011748.1 similar to general secretory pathway protein L; GspL-like protein 3452215 yghE 7148879 yghE Escherichia coli 55989 GspL-like protein YP_002404332.1 3451037 R 585055 CDS YP_002404333.1 218696666 7148880 complement(3452212..3453189) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; type II secretion protein (GspK-like) 3453189 7148880 EC55989_3371 Escherichia coli 55989 type II secretion protein (GspK-like) YP_002404333.1 3452212 R 585055 CDS YP_002404334.1 218696667 7144975 complement(3453192..3453791) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3453791 7144975 EC55989_3372 Escherichia coli 55989 hypothetical protein YP_002404334.1 3453192 R 585055 CDS YP_002404335.1 218696668 7144976 complement(3453788..3454159) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; type II secretion protein (GspI-like) 3454159 7144976 EC55989_3373 Escherichia coli 55989 type II secretion protein (GspI-like) YP_002404335.1 3453788 R 585055 CDS YP_002404336.1 218696669 7144977 complement(3454156..3454719) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3454719 7144977 EC55989_3374 Escherichia coli 55989 hypothetical protein YP_002404336.1 3454156 R 585055 CDS YP_002404337.1 218696670 7144978 complement(3454723..3455205) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; general secretion pathway protein G precursor (epsG-like) 3455205 7144978 EC55989_3375 Escherichia coli 55989 general secretion pathway protein G precursor (epsG-like) YP_002404337.1 3454723 R 585055 CDS YP_002404338.1 218696671 7144979 complement(3455195..3456418) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; General secretion pathway protein F 3456418 epsF 7144979 epsF Escherichia coli 55989 General secretion pathway protein F YP_002404338.1 3455195 R 585055 CDS YP_002404339.1 218696672 7146017 complement(3456418..3457911) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein E 3457911 epsE 7146017 epsE Escherichia coli 55989 general secretion pathway protein E YP_002404339.1 3456418 R 585055 CDS YP_002404340.1 218696673 7146016 complement(3457911..3459971) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein D 3459971 epsD 7146016 epsD Escherichia coli 55989 general secretion pathway protein D YP_002404340.1 3457911 R 585055 CDS YP_002404341.1 218696674 7146015 complement(3460001..3460960) 1 NC_011748.1 part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm; type II secretion protein GspC 3460960 yghF 7146015 yghF Escherichia coli 55989 type II secretion protein GspC YP_002404341.1 3460001 R 585055 CDS YP_002404342.1 218696675 7148881 complement(3460978..3461388) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3461388 yghG 7148881 yghG Escherichia coli 55989 hypothetical protein YP_002404342.1 3460978 R 585055 CDS YP_002404343.1 218696676 7148882 complement(3461454..3462263) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98175453; Product type e : enzyme; bifunctional prepilin leader peptidase and methylase 3462263 pppA 7148882 pppA Escherichia coli 55989 bifunctional prepilin leader peptidase and methylase YP_002404343.1 3461454 R 585055 CDS YP_002404344.1 218696677 7147233 complement(3462403..3466986) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 1644747; Product type lp : lipoprotein; inner membrane lipoprotein 3466986 yghJ 7147233 yghJ Escherichia coli 55989 inner membrane lipoprotein YP_002404344.1 3462403 R 585055 CDS YP_002404345.1 218696678 7148883 3467116..3467328 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3467328 7148883 EC55989_3383 Escherichia coli 55989 hypothetical protein YP_002404345.1 3467116 D 585055 CDS YP_002404346.1 218696679 7144980 complement(3467454..3469136) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11785976, 21178909, 11283302; Product type t : transporter; glycolate transporter 3469136 yghK 7144980 yghK Escherichia coli 55989 glycolate transporter YP_002404346.1 3467454 R 585055 CDS YP_002404347.1 218696680 7148884 complement(3469492..3471663) 1 NC_011748.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G 3471663 glcB 7148884 glcB Escherichia coli 55989 malate synthase G YP_002404347.1 3469492 R 585055 CDS YP_002404348.1 218696681 7146285 complement(3471685..3472089) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3472089 glcG 7146285 glcG Escherichia coli 55989 hypothetical protein YP_002404348.1 3471685 R 585055 CDS YP_002404349.1 218696682 7146290 complement(3472094..3473317) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type c : carrier; glycolate oxidase iron-sulfur subunit 3473317 glcF 7146290 glcF Escherichia coli 55989 glycolate oxidase iron-sulfur subunit YP_002404349.1 3472094 R 585055 CDS YP_002404350.1 218696683 7146289 complement(3473328..3474380) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase FAD binding subunit 3474380 glcE 7146289 glcE Escherichia coli 55989 glycolate oxidase FAD binding subunit YP_002404350.1 3473328 R 585055 CDS YP_002404351.1 218696684 7146288 complement(3474380..3475879) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase subunit GlcD 3475879 glcD 7146288 glcD Escherichia coli 55989 glycolate oxidase subunit GlcD YP_002404351.1 3474380 R 585055 CDS YP_002404352.1 218696685 7146286 complement(3476720..3477223) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 273224, 375010, 1849492; Product type pe : enzyme; transposase ORF B IS1 3477223 7146286 EC55989_3391 Escherichia coli 55989 transposase ORF B IS1 YP_002404352.1 3476720 R 585055 CDS YP_002404353.1 218696686 7144981 complement(3477142..3477417) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 3477417 insA 7144981 insA Escherichia coli 55989 IS1 repressor protein InsA YP_002404353.1 3477142 R 585055 CDS YP_002404354.1 218696687 7144982 3477551..3478723 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; 8-amino-7-oxononanoate synthase 3478723 7144982 EC55989_3394 Escherichia coli 55989 8-amino-7-oxononanoate synthase YP_002404354.1 3477551 D 585055 CDS YP_002404355.1 218696688 7144983 complement(3478758..3479918) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3479918 7144983 EC55989_3395 Escherichia coli 55989 hypothetical protein YP_002404355.1 3478758 R 585055 CDS YP_002404356.1 218696689 7144984 complement(3479834..3480904) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3480904 7144984 EC55989_3396 Escherichia coli 55989 hypothetical protein YP_002404356.1 3479834 R 585055 CDS YP_002404357.1 218696690 7144985 complement(3480935..3481498) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 3481498 7144985 EC55989_3397 Escherichia coli 55989 transcriptional regulator YP_002404357.1 3480935 R 585055 CDS YP_002404358.1 218696691 7144986 complement(3481507..3482331) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3482331 7144986 EC55989_3398 Escherichia coli 55989 hypothetical protein YP_002404358.1 3481507 R 585055 CDS YP_002404359.1 218696692 7144987 complement(3482331..3483680) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; membrane protein, conserved protein 3483680 7144987 EC55989_3399 Escherichia coli 55989 membrane protein, conserved protein YP_002404359.1 3482331 R 585055 CDS YP_002404360.1 218696693 7144988 complement(3483726..3484484) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; nucleoside triphosphate hydrolase domain 3484484 yghR 7144988 yghR Escherichia coli 55989 nucleoside triphosphate hydrolase domain YP_002404360.1 3483726 R 585055 CDS YP_002404361.1 218696694 7148885 complement(3484516..3485229) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; nucleoside triphosphate hydrolase domain 3485229 yghS 7148885 yghS Escherichia coli 55989 nucleoside triphosphate hydrolase domain YP_002404361.1 3484516 R 585055 CDS YP_002404362.1 218696695 7148886 3485403..3486095 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; nucleoside triphosphate hydrolase domain 3486095 yghT 7148886 yghT Escherichia coli 55989 nucleoside triphosphate hydrolase domain YP_002404362.1 3485403 D 585055 CDS YP_002404363.1 218696696 7148887 complement(3486144..3487643) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21336523, 21382172, 7775463; Product type t : transporter; phosphate transporter 3487643 pitB 7148887 pitB Escherichia coli 55989 phosphate transporter YP_002404363.1 3486144 R 585055 CDS YP_002404364.1 218696697 7147192 complement(3487935..3489794) 1 NC_011748.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase 3489794 gss 7147192 gss Escherichia coli 55989 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase YP_002404364.1 3487935 R 585055 CDS YP_002404365.1 218696698 7146376 3489999..3490865 1 NC_011748.1 YghU; B2989; one of eight glutathione transferase proteins from E. coli; glutathione S-transferase 3490865 yghU 7146376 yghU Escherichia coli 55989 glutathione S-transferase YP_002404365.1 3489999 D 585055 CDS YP_002404366.1 218696699 7148888 3491165..3492145 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 3492145 7148888 EC55989_3406 Escherichia coli 55989 transposase, IS110 family YP_002404366.1 3491165 D 585055 CDS YP_002404367.1 218696700 7144989 complement(3492267..3492515) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 94292472, 8021226; Product type pf : factor; hydrogenase 2 accessory protein HypG 3492515 hybG 7144989 hybG Escherichia coli 55989 hydrogenase 2 accessory protein HypG YP_002404367.1 3492267 R 585055 CDS YP_002404368.1 218696701 7146494 complement(3492528..3492869) 1 NC_011748.1 plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF 3492869 hybF 7146494 hybF Escherichia coli 55989 hydrogenase nickel incorporation protein HybF YP_002404368.1 3492528 R 585055 CDS YP_002404369.1 218696702 7146493 complement(3492862..3493350) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292472, 8021226; Product type f : factor; hydrogenase 2-specific chaperone 3493350 hybE 7146493 hybE Escherichia coli 55989 hydrogenase 2-specific chaperone YP_002404369.1 3492862 R 585055 CDS YP_002404370.1 218696703 7146492 complement(3493343..3493837) 1 NC_011748.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase 3493837 hybD 7146492 hybD Escherichia coli 55989 hydrogenase 2 maturation endopeptidase YP_002404370.1 3493343 R 585055 CDS YP_002404371.1 218696704 7146491 complement(3493837..3495540) 1 NC_011748.1 involved in hydrogen uptake; hydrogenase 2 large subunit 3495540 hybC 7146491 hybC Escherichia coli 55989 hydrogenase 2 large subunit YP_002404371.1 3493837 R 585055 CDS YP_002404372.1 218696705 7146490 complement(3495537..3496715) 1 NC_011748.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; hydrogenase 2 b cytochrome subunit 3496715 hybB 7146490 hybB Escherichia coli 55989 hydrogenase 2 b cytochrome subunit YP_002404372.1 3495537 R 585055 CDS YP_002404373.1 218696706 7146489 complement(3496705..3497691) 1 NC_011748.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA 3497691 hybA 7146489 hybA Escherichia coli 55989 hydrogenase 2 protein HybA YP_002404373.1 3496705 R 585055 CDS YP_002404374.1 218696707 7146488 complement(3497694..3498812) 1 NC_011748.1 involved in hydrogen uptake; hydrogenase 2 small subunit 3498812 hybO 7146488 hybO Escherichia coli 55989 hydrogenase 2 small subunit YP_002404374.1 3497694 R 585055 CDS YP_002404375.1 218696708 7146495 complement(3498819..3499004) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 3499004 7146495 EC55989_3415 Escherichia coli 55989 hypothetical protein YP_002404375.1 3498819 R 585055 CDS YP_002404376.1 218696709 7144990 complement(3499001..3499288) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3499288 yghW 7144990 yghW Escherichia coli 55989 hypothetical protein YP_002404376.1 3499001 R 585055 CDS YP_002404377.1 218696710 7148889 complement(3499407..3500333) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3500333 7148889 EC55989_3417 Escherichia coli 55989 hypothetical protein YP_002404377.1 3499407 R 585055 CDS YP_002404378.1 218696711 7144991 3500451..3501491 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12583903; Product type e : enzyme; aldo/keto reductase 3501491 yghZ 7144991 yghZ Escherichia coli 55989 aldo/keto reductase YP_002404378.1 3500451 D 585055 CDS YP_002404379.1 218696712 7148890 complement(3501531..3502025) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 3502025 yqhA 7148890 yqhA Escherichia coli 55989 hypothetical protein YP_002404379.1 3501531 R 585055 CDS YP_002404380.1 218696713 7149413 3502216..3503100 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase 3503100 yghA 7149413 yghA Escherichia coli 55989 oxidoreductase YP_002404380.1 3502216 D 585055 CDS YP_002404381.1 218696714 7148877 complement(3503139..3503564) 1 NC_011748.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD 3503564 exbD 7148877 exbD Escherichia coli 55989 biopolymer transport protein ExbD YP_002404381.1 3503139 R 585055 CDS YP_002404382.1 218696715 7146041 complement(3503571..3504305) 1 NC_011748.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB 3504305 exbB 7146041 exbB Escherichia coli 55989 biopolymer transport protein ExbB YP_002404382.1 3503571 R 585055 CDS YP_002404383.1 218696716 7146040 complement(3504298..3504453) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 3504453 7146040 EC55989_3424 Escherichia coli 55989 hypothetical protein YP_002404383.1 3504298 R 585055 CDS YP_002404384.1 218696717 7144992 3504557..3505744 1 NC_011748.1 catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3505744 metC 7144992 metC Escherichia coli 55989 cystathionine beta-lyase YP_002404384.1 3504557 D 585055 CDS YP_002404385.1 218696718 7146826 3505884..3506543 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3506543 yghB 7146826 yghB Escherichia coli 55989 inner membrane protein YP_002404385.1 3505884 D 585055 CDS YP_002404386.1 218696719 7148878 complement(3506583..3507539) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 3507539 yqhC 7148878 yqhC Escherichia coli 55989 DNA-binding transcriptional regulator YP_002404386.1 3506583 R 585055 CDS YP_002404387.1 218696720 7149414 3507676..3508839 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15327949; Product type e : enzyme; alcohol dehydrogenase 3508839 yqhD 7149414 yqhD Escherichia coli 55989 alcohol dehydrogenase YP_002404387.1 3507676 D 585055 CDS YP_002404388.1 218696721 7149415 3508944..3509771 1 NC_011748.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3509771 dkgA 7149415 dkgA Escherichia coli 55989 2,5-diketo-D-gluconate reductase A YP_002404388.1 3508944 D 585055 CDS YP_002404389.1 218696722 7145924 3509971..3510897 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3510897 yqhG 7145924 yqhG Escherichia coli 55989 hypothetical protein YP_002404389.1 3509971 D 585055 CDS YP_002404390.1 218696723 7149416 3510948..3511205 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; outer membrane lipoprotein 3511205 yqhH 7149416 yqhH Escherichia coli 55989 outer membrane lipoprotein YP_002404390.1 3510948 D 585055 CDS YP_002404391.1 218696724 7149417 complement(3511248..3513467) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3513467 ygiQ 7149417 ygiQ Escherichia coli 55989 hypothetical protein YP_002404391.1 3511248 R 585055 CDS YP_002404392.1 218696725 7148898 complement(3513578..3514990) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88314889, 1557036, 9298646; Product type r : regulator; repressor protein for FtsI 3514990 sufI 7148898 sufI Escherichia coli 55989 repressor protein for FtsI YP_002404392.1 3513578 R 585055 CDS YP_002404393.1 218696726 7147735 complement(3515065..3515802) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212294, 1557036; Product type e : enzyme; 1-acyl-sn-glycerol-3-phosphate acyltransferase 3515802 plsC 7147735 plsC Escherichia coli 55989 1-acyl-sn-glycerol-3-phosphate acyltransferase YP_002404393.1 3515065 R 585055 CDS YP_002404394.1 218696727 7147196 complement(3515850..3516005) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3516005 7147196 EC55989_3435 Escherichia coli 55989 hypothetical protein YP_002404394.1 3515850 R 585055 CDS YP_002404395.1 218696728 7144993 complement(3516035..3518293) 1 NC_011748.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A 3518293 parC 7144993 parC Escherichia coli 55989 DNA topoisomerase IV subunit A YP_002404395.1 3516035 R 585055 CDS YP_002404396.1 218696729 7147115 complement(3518839..3519321) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 3519321 ygiV 7147115 ygiV Escherichia coli 55989 transcriptional regulator YP_002404396.1 3518839 R 585055 CDS YP_002404397.1 218696730 7148899 complement(3519374..3519766) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein 3519766 ygiW 7148899 ygiW Escherichia coli 55989 hypothetical protein YP_002404397.1 3519374 R 585055 CDS YP_002404398.1 218696731 7148900 3519918..3520577 1 NC_011748.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3520577 qseB 7148900 qseB Escherichia coli 55989 DNA-binding transcriptional regulator QseB YP_002404398.1 3519918 D 585055 CDS YP_002404399.1 218696732 7147329 3520574..3521923 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21927389; Product type r : regulator; sensor protein QseC 3521923 qseC 7147329 qseC Escherichia coli 55989 sensor protein QseC YP_002404399.1 3520574 D 585055 CDS YP_002404400.1 218696733 7147330 complement(3521969..3522301) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3522301 ygiZ 7147330 ygiZ Escherichia coli 55989 inner membrane protein YP_002404400.1 3521969 R 585055 CDS YP_002404401.1 218696734 7148901 3522620..3523201 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96004656, 96217538; Product type c : carrier; NADPH quinone reductase 3523201 mdaB 7148901 mdaB Escherichia coli 55989 NADPH quinone reductase YP_002404401.1 3522620 D 585055 CDS YP_002404402.1 218696735 7146793 3523232..3523546 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10493123, 9298646, 9600841, 9868784; Product type e : enzyme; quinol monooxygenase 3523546 ygiN 7146793 ygiN Escherichia coli 55989 quinol monooxygenase YP_002404402.1 3523232 D 585055 CDS YP_002404403.1 218696736 7148896 complement(3523594..3525486) 1 NC_011748.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B 3525486 parE 7148896 parE Escherichia coli 55989 DNA topoisomerase IV subunit B YP_002404403.1 3523594 R 585055 CDS YP_002404404.1 218696737 7147116 complement(3525515..3526096) 1 NC_011748.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YqiA 3526096 yqiA 7147116 yqiA Escherichia coli 55989 esterase YqiA YP_002404404.1 3525515 R 585055 CDS YP_002404405.1 218696738 7149418 complement(3526096..3526923) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96411758; Product type e : enzyme; cyclic 3',5'-adenosine monophosphate phosphodiesterase 3526923 cpdA 7149418 cpdA Escherichia coli 55989 cyclic 3',5'-adenosine monophosphate phosphodiesterase YP_002404405.1 3526096 R 585055 CDS YP_002404406.1 218696739 7145744 complement(3526948..3527370) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 3527370 yqiB 7145744 yqiB Escherichia coli 55989 hypothetical protein YP_002404406.1 3526948 R 585055 CDS YP_002404407.1 218696740 7149419 complement(3527371..3528000) 1 NC_011748.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase 3528000 nudF 7149419 nudF Escherichia coli 55989 ADP-ribose pyrophosphatase YP_002404407.1 3527371 R 585055 CDS YP_002404408.1 218696741 7147040 3528205..3529686 1 NC_011748.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3529686 tolC 7147040 tolC Escherichia coli 55989 outer membrane channel protein YP_002404408.1 3528205 D 585055 CDS YP_002404409.1 218696742 7147814 3529930..3530505 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 3530505 ygiB 7147814 ygiB Escherichia coli 55989 hypothetical protein YP_002404409.1 3529930 D 585055 CDS YP_002404410.1 218696743 7148891 3530511..3531671 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 3531671 ygiC 7148891 ygiC Escherichia coli 55989 hypothetical protein YP_002404410.1 3530511 D 585055 CDS YP_002404411.1 218696744 7148892 complement(3531709..3532524) 1 NC_011748.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein 3532524 zupT 7148892 zupT Escherichia coli 55989 hypothetical protein YP_002404411.1 3531709 R 585055 CDS YP_002404412.1 218696745 7149498 3532640..3533413 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790762, 1314093; Product type t : transporter; zinc transporter ZupT 3533413 ygiE 7149498 ygiE Escherichia coli 55989 zinc transporter ZupT YP_002404412.1 3532640 D 585055 CDS YP_002404413.1 218696746 7148893 complement(3533471..3533665) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3533665 7148893 EC55989_3456 Escherichia coli 55989 hypothetical protein YP_002404413.1 3533471 R 585055 CDS YP_002404414.1 218696747 7144994 complement(3533902..3534555) 1 NC_011748.1 DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase 3534555 ribB 7144994 ribB Escherichia coli 55989 3,4-dihydroxy-2-butanone 4-phosphate synthase YP_002404414.1 3533902 R 585055 CDS YP_002404415.1 218696748 7145311 3534929..3535219 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3535219 yqiC 7145311 yqiC Escherichia coli 55989 hypothetical protein YP_002404415.1 3534929 D 585055 CDS YP_002404416.1 218696749 7149420 3535502..3536053 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial protein 3536053 ygiL 7149420 ygiL Escherichia coli 55989 fimbrial protein YP_002404416.1 3535502 D 585055 CDS YP_002404417.1 218696750 7148895 3536104..3538617 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; outer membrane usher protein 3538617 yqiG 7148895 yqiG Escherichia coli 55989 outer membrane usher protein YP_002404417.1 3536104 D 585055 CDS YP_002404418.1 218696751 7149421 3538633..3539382 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; periplasmic pilin chaperone 3539382 yqiH 7149421 yqiH Escherichia coli 55989 periplasmic pilin chaperone YP_002404418.1 3538633 D 585055 CDS YP_002404419.1 218696752 7149422 3539384..3540448 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3540448 yqiI 7149422 yqiI Escherichia coli 55989 hypothetical protein YP_002404419.1 3539384 D 585055 CDS YP_002404420.1 218696753 7149423 complement(3540491..3540691) 1 NC_011748.1 Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS 3540691 glgS 7149423 glgS Escherichia coli 55989 glycogen synthesis protein GlgS YP_002404420.1 3540491 R 585055 CDS YP_002404421.1 218696754 7146296 3540960..3541589 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3541589 yqiJ 7146296 yqiJ Escherichia coli 55989 inner membrane protein YP_002404421.1 3540960 D 585055 CDS YP_002404422.1 218696755 7149424 3541616..3543277 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3543277 yqiK 7149424 yqiK Escherichia coli 55989 hypothetical protein YP_002404422.1 3541616 D 585055 CDS YP_002404423.1 218696756 7145312 complement(3544071..3545504) 1 NC_011748.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase 3545504 rfaE 7145312 rfaE Escherichia coli 55989 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase YP_002404423.1 3544071 R 585055 CDS YP_002404424.1 218696757 7147374 complement(3545552..3548392) 1 NC_011748.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase 3548392 glnE 7147374 glnE Escherichia coli 55989 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase YP_002404424.1 3545552 R 585055 CDS YP_002404425.1 218696758 7146305 complement(3548415..3549716) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8412694; Product type pe : enzyme; adenylate cyclase 3549716 ygiF 7146305 ygiF Escherichia coli 55989 adenylate cyclase YP_002404425.1 3548415 R 585055 CDS YP_002404426.1 218696759 7148894 complement(3549733..3549939) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 3549939 7148894 EC55989_3469 Escherichia coli 55989 hypothetical protein YP_002404426.1 3549733 R 585055 CDS YP_002404427.1 218696760 7144995 3549958..3550578 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11274153; Product type pr : regulator; signal transduction protein 3550578 htrG 7144995 htrG Escherichia coli 55989 signal transduction protein YP_002404427.1 3549958 D 585055 CDS YP_002404428.1 218696761 7146478 3550642..3551880 1 NC_011748.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3551880 cca 7146478 cca Escherichia coli 55989 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase YP_002404428.1 3550642 D 585055 CDS YP_002404429.1 218696762 7145671 complement(3552043..3552864) 1 NC_011748.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase 3552864 bacA 7145671 bacA Escherichia coli 55989 undecaprenyl pyrophosphate phosphatase YP_002404429.1 3552043 R 585055 CDS YP_002404430.1 218696763 7145592 complement(3552955..3553323) 1 NC_011748.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase 3553323 folB 7145592 folB Escherichia coli 55989 bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase YP_002404430.1 3552955 R 585055 CDS YP_002404431.1 218696764 7146169 3553428..3554045 1 NC_011748.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 3554045 plsY 7146169 plsY Escherichia coli 55989 glycerol-3-phosphate acyltransferase PlsY YP_002404431.1 3553428 D 585055 CDS YP_002404432.1 218696765 7147198 complement(3554058..3554990) 1 NC_011748.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR 3554990 ygiP 7147198 ygiP Escherichia coli 55989 transcriptional activator TtdR YP_002404432.1 3554058 R 585055 CDS YP_002404433.1 218696766 7148897 3555197..3556108 1 NC_011748.1 Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3556108 ttdA 7148897 ttdA Escherichia coli 55989 tartrate dehydratase subunit alpha YP_002404433.1 3555197 D 585055 CDS YP_002404434.1 218696767 7147869 3556105..3556710 1 NC_011748.1 Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3556710 ttdB 7147869 ttdB Escherichia coli 55989 L(+)-tartrate dehydratase subunit beta YP_002404434.1 3556105 D 585055 CDS YP_002404435.1 218696768 7147870 3556759..3558222 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; tartrate:succinate antiporter 3558222 ygjE 7147870 ygjE Escherichia coli 55989 tartrate:succinate antiporter YP_002404435.1 3556759 D 585055 CDS YP_002404436.1 218696769 7148902 complement(3558265..3559278) 1 NC_011748.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease 3559278 gcp 7148902 gcp Escherichia coli 55989 DNA-binding/iron metalloprotein/AP endonuclease YP_002404436.1 3558265 R 585055 CDS YP_002404437.1 218696770 7146273 3559515..3559730 1 NC_011748.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3559730 rpsU 7146273 rpsU Escherichia coli 55989 30S ribosomal protein S21 YP_002404437.1 3559515 D 585055 CDS YP_002404438.1 218696771 7147525 3559841..3561586 1 NC_011748.1 synthesizes RNA primers at the replication forks; DNA primase 3561586 dnaG 7147525 dnaG Escherichia coli 55989 DNA primase YP_002404438.1 3559841 D 585055 CDS YP_002404439.1 218696772 7145936 3561781..3563622 1 NC_011748.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3563622 rpoD 7145936 rpoD Escherichia coli 55989 RNA polymerase sigma factor RpoD YP_002404439.1 3561781 D 585055 CDS YP_002404440.1 218696773 7147498 complement(3563700..3564206) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20412902, 99453007, 6269063, 7567469, 8878487, 9489705; Product type e : enzyme; G/U mismatch-specific DNA glycosylase 3564206 ygjF 7147498 ygjF Escherichia coli 55989 G/U mismatch-specific DNA glycosylase YP_002404440.1 3563700 R 585055 CDS YP_002404441.1 218696774 7145345 complement(3564460..3565224) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; siderophore interacting protein 3565224 yqjH 7145345 yqjH Escherichia coli 55989 siderophore interacting protein YP_002404441.1 3564460 R 585055 CDS YP_002404442.1 218696775 7149433 3565501..3566124 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 3566124 yqjI 7149433 yqjI Escherichia coli 55989 transcriptional regulator YP_002404442.1 3565501 D 585055 CDS YP_002404443.1 218696776 7149434 complement(3566278..3567798) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 9380671, 9643537, 9190831; Product type r : regulator; fused signal transducer for aerotaxis sensory component ; methyl accepting chemotaxis component 3567798 aer 7149434 aer Escherichia coli 55989 fused signal transducer for aerotaxis sensory component ; methyl accepting chemotaxis component YP_002404443.1 3566278 R 585055 CDS YP_002404444.1 218696777 7145463 3568189..3569595 1 NC_011748.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3569595 ygjG 7145463 ygjG Escherichia coli 55989 putrescine--2-oxoglutarate aminotransferase YP_002404444.1 3568189 D 585055 CDS YP_002404445.1 218696778 7148904 complement(3569637..3569969) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11101501; hypothetical protein 3569969 ygjH 7148904 ygjH Escherichia coli 55989 hypothetical protein YP_002404445.1 3569637 R 585055 CDS YP_002404446.1 218696779 7148905 3570188..3571171 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89128452, 2515108, 3939708; Product type r : regulator; DNA-binding transcriptional repressor EbgR 3571171 ebgR 7148905 ebgR Escherichia coli 55989 DNA-binding transcriptional repressor EbgR YP_002404446.1 3570188 D 585055 CDS YP_002404447.1 218696780 7145969 3571355..3574447 1 NC_011748.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3574447 ebgA 7145969 ebgA Escherichia coli 55989 cryptic beta-D-galactosidase subunit alpha YP_002404447.1 3571355 D 585055 CDS YP_002404448.1 218696781 7145967 3574444..3574893 1 NC_011748.1 in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3574893 ebgC 7145967 ebgC Escherichia coli 55989 cryptic beta-D-galactosidase subunit beta YP_002404448.1 3574444 D 585055 CDS YP_002404449.1 218696782 7145968 3574956..3576389 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 3576389 ygjI 7145968 ygjI Escherichia coli 55989 transporter YP_002404449.1 3574956 D 585055 CDS YP_002404450.1 218696783 7148906 3576523..3577593 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3577593 ygjJ 7148906 ygjJ Escherichia coli 55989 hypothetical protein YP_002404450.1 3576523 D 585055 CDS YP_002404451.1 218696784 7148907 3577610..3579961 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213393; Product type pe : enzyme; glycosyl hydrolase 3579961 ygjK 7148907 ygjK Escherichia coli 55989 glycosyl hydrolase YP_002404451.1 3577610 D 585055 CDS YP_002404452.1 218696785 7148908 3580287..3582305 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12840019, 89380266; Product type e : enzyme; 2,4-dienoyl-CoA reductase 3582305 fadH 7148908 fadH Escherichia coli 55989 2,4-dienoyl-CoA reductase YP_002404452.1 3580287 D 585055 CDS YP_002404453.1 218696786 7146059 complement(3582350..3582766) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 3582766 ygjM 7146059 ygjM Escherichia coli 55989 DNA-binding transcriptional regulator YP_002404453.1 3582350 R 585055 CDS YP_002404454.1 218696787 7148909 complement(3582763..3582933) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3582933 7148909 EC55989_3497 Escherichia coli 55989 hypothetical protein YP_002404454.1 3582763 R 585055 CDS YP_002404455.1 218696788 7144996 complement(3583037..3584173) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; methyltransferase small domain 3584173 ygjO 7144996 ygjO Escherichia coli 55989 methyltransferase small domain YP_002404455.1 3583037 R 585055 CDS YP_002404456.1 218696789 7148910 3584258..3584761 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; metal dependent hydrolase 3584761 ygjP 7148910 ygjP Escherichia coli 55989 metal dependent hydrolase YP_002404456.1 3584258 D 585055 CDS YP_002404457.1 218696790 7148911 3584838..3585521 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; thioredoxin-like protein 3585521 ygjQ 7148911 ygjQ Escherichia coli 55989 thioredoxin-like protein YP_002404457.1 3584838 D 585055 CDS YP_002404458.1 218696791 7148912 3585582..3586586 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; NAD(P)-binding dehydrogenase 3586586 ygjR 7148912 ygjR Escherichia coli 55989 NAD(P)-binding dehydrogenase YP_002404458.1 3585582 D 585055 CDS YP_002404459.1 218696792 7147700 3586869..3587834 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12107143, 2108134; Product type pm : membrane component; inner membrane protein, part of terminus 3587834 alx 7147700 alx Escherichia coli 55989 inner membrane protein, part of terminus YP_002404459.1 3586869 D 585055 CDS YP_002404460.1 218696793 7145489 3588233..3589477 1 NC_011748.1 involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3589477 sstT 7145489 sstT Escherichia coli 55989 serine/threonine transporter SstT YP_002404460.1 3588233 D 585055 CDS YP_002404461.1 218696794 7147718 complement(3589482..3590033) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3590033 ygjV 7147718 ygjV Escherichia coli 55989 inner membrane protein YP_002404461.1 3589482 R 585055 CDS YP_002404462.1 218696795 7148914 complement(3590116..3591603) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4570160, 83114543, 3038546; Product type e : enzyme; altronate hydrolase 3591603 uxaA 7148914 uxaA Escherichia coli 55989 altronate hydrolase YP_002404462.1 3590116 R 585055 CDS YP_002404463.1 218696796 7147938 complement(3591618..3593030) 1 NC_011748.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase 3593030 uxaC 7147938 uxaC Escherichia coli 55989 glucuronate isomerase YP_002404463.1 3591618 R 585055 CDS YP_002404464.1 218696797 7147940 3593393..3594811 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83218546, 98190790; Product type t : transporter; hexuronate transporter 3594811 exuT 7147940 exuT Escherichia coli 55989 hexuronate transporter YP_002404464.1 3593393 D 585055 CDS YP_002404465.1 218696798 7146045 complement(3594899..3595987) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3595987 7146045 EC55989_3508 Escherichia coli 55989 hypothetical protein YP_002404465.1 3594899 R 585055 CDS YP_002404466.1 218696799 7144997 complement(3595984..3598686) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3598686 7144997 EC55989_3509 Escherichia coli 55989 hypothetical protein YP_002404466.1 3595984 R 585055 CDS YP_002404467.1 218696800 7144998 complement(3598760..3599260) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; adhesin major subunit pilin 3599260 7144998 EC55989_3510 Escherichia coli 55989 adhesin major subunit pilin YP_002404467.1 3598760 R 585055 CDS YP_002404468.1 218696801 7144999 complement(3599290..3600006) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial protein 3600006 7144999 EC55989_3511 Escherichia coli 55989 fimbrial protein YP_002404468.1 3599290 R 585055 CDS YP_002404469.1 218696802 7145000 3600302..3601078 1 NC_011748.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3601078 exuR 7145000 exuR Escherichia coli 55989 DNA-binding transcriptional repressor ExuR YP_002404469.1 3600302 D 585055 CDS YP_002404470.1 218696803 7146044 3601423..3602085 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3602085 yqjA 7146044 yqjA Escherichia coli 55989 inner membrane protein YP_002404470.1 3601423 D 585055 CDS YP_002404471.1 218696804 7149426 3602089..3602472 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3602472 yqjB 7149426 yqjB Escherichia coli 55989 hypothetical protein YP_002404471.1 3602089 D 585055 CDS YP_002404472.1 218696805 7149427 3602619..3602987 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3602987 yqjC 7149427 yqjC Escherichia coli 55989 hypothetical protein YP_002404472.1 3602619 D 585055 CDS YP_002404473.1 218696806 7149428 3603025..3603330 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3603330 yqjD 7149428 yqjD Escherichia coli 55989 hypothetical protein YP_002404473.1 3603025 D 585055 CDS YP_002404474.1 218696807 7149429 3603333..3603737 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3603737 yqjE 7149429 yqjE Escherichia coli 55989 inner membrane protein YP_002404474.1 3603333 D 585055 CDS YP_002404475.1 218696808 7149430 3603727..3604026 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3604026 yqjK 7149430 yqjK Escherichia coli 55989 hypothetical protein YP_002404475.1 3603727 D 585055 CDS YP_002404476.1 218696809 7149435 3604212..3604604 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; quinol oxidase subunit 3604604 yqjF 7149435 yqjF Escherichia coli 55989 quinol oxidase subunit YP_002404476.1 3604212 D 585055 CDS YP_002404477.1 218696810 7149431 3604674..3605660 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8478329; Product type e : enzyme; S-transferase 3605660 yqjG 7149431 yqjG Escherichia coli 55989 S-transferase YP_002404477.1 3604674 D 585055 CDS YP_002404478.1 218696811 7149432 3605953..3606318 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3606318 yhaH 7149432 yhaH Escherichia coli 55989 inner membrane protein YP_002404478.1 3605953 D 585055 CDS YP_002404479.1 218696812 7148917 3606560..3606916 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3606916 yhaI 7148917 yhaI Escherichia coli 55989 inner membrane protein YP_002404479.1 3606560 D 585055 CDS YP_002404480.1 218696813 7148918 complement(3606967..3607863) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 3607863 yhaJ 7148918 yhaJ Escherichia coli 55989 DNA-binding transcriptional regulator YP_002404480.1 3606967 R 585055 CDS YP_002404481.1 218696814 7148919 3607968..3608669 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; pirin-related protein 3608669 yhaK 7148919 yhaK Escherichia coli 55989 pirin-related protein YP_002404481.1 3607968 D 585055 CDS YP_002404482.1 218696815 7148920 3608692..3608856 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3608856 yhaL 7148920 yhaL Escherichia coli 55989 hypothetical protein YP_002404482.1 3608692 D 585055 CDS YP_002404483.1 218696816 7148921 complement(3608917..3610227) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3610227 yhaM 7148921 yhaM Escherichia coli 55989 hypothetical protein YP_002404483.1 3608917 R 585055 CDS YP_002404484.1 218696817 7148922 complement(3610255..3611523) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 3611523 yhaO 7148922 yhaO Escherichia coli 55989 transporter YP_002404484.1 3610255 R 585055 CDS YP_002404485.1 218696818 7148923 complement(3611861..3613225) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; L-serine dehydratase 3 3613225 tdcG 7148923 tdcG Escherichia coli 55989 L-serine dehydratase 3 YP_002404485.1 3611861 R 585055 CDS YP_002404486.1 218696819 7147769 complement(3613297..3613686) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 12777779, 9484901; Product type e : enzyme; hypothetical protein 3613686 tdcF 7147769 tdcF Escherichia coli 55989 hypothetical protein YP_002404486.1 3613297 R 585055 CDS YP_002404487.1 218696820 7147768 complement(3613700..3615994) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; pyruvate formate-lyase 4/2-ketobutyrate formate-lyase 3615994 tdcE 7147768 tdcE Escherichia coli 55989 pyruvate formate-lyase 4/2-ketobutyrate formate-lyase YP_002404487.1 3613700 R 585055 CDS YP_002404488.1 218696821 7147767 complement(3616028..3617248) 1 NC_011748.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase 3617248 tdcD 7147767 tdcD Escherichia coli 55989 propionate/acetate kinase YP_002404488.1 3616028 R 585055 CDS YP_002404489.1 218696822 7147766 complement(3617262..3618593) 1 NC_011748.1 involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC 3618593 tdcC 7147766 tdcC Escherichia coli 55989 threonine/serine transporter TdcC YP_002404489.1 3617262 R 585055 CDS YP_002404490.1 218696823 7147765 complement(3618615..3619604) 1 NC_011748.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase 3619604 tdcB 7147765 tdcB Escherichia coli 55989 threonine dehydratase YP_002404490.1 3618615 R 585055 CDS YP_002404491.1 218696824 7147764 complement(3619703..3620641) 1 NC_011748.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA 3620641 tdcA 7147764 tdcA Escherichia coli 55989 DNA-binding transcriptional activator TdcA YP_002404491.1 3619703 R 585055 CDS YP_002404492.1 218696825 7147763 3620818..3621174 1 NC_011748.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3621174 tdcR 7147763 tdcR Escherichia coli 55989 DNA-binding transcriptional activator TdcR YP_002404492.1 3620818 D 585055 CDS YP_002404493.1 218696826 7147770 3621430..3621969 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3621969 yhaB 7147770 yhaB Escherichia coli 55989 hypothetical protein YP_002404493.1 3621430 D 585055 CDS YP_002404494.1 218696827 7148915 3621991..3623178 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1705543, 2573820, 2660107, 6351058; hypothetical protein 3623178 yhaC 7148915 yhaC Escherichia coli 55989 hypothetical protein YP_002404494.1 3621991 D 585055 CDS YP_002404495.1 218696828 7148916 3623516..3624496 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 3624496 7148916 EC55989_3540 Escherichia coli 55989 transposase, IS110 family YP_002404495.1 3623516 D 585055 CDS YP_002404496.1 218696829 7147454 complement(3625593..3626819) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 69151449, 9772162; Product type e : enzyme; glycerate kinase 3626819 garK 7147454 garK Escherichia coli 55989 glycerate kinase YP_002404496.1 3625593 R 585055 CDS YP_002404497.1 218696830 7146259 complement(3626835..3627725) 1 NC_011748.1 catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase 3627725 garR 7146259 garR Escherichia coli 55989 tartronate semialdehyde reductase YP_002404497.1 3626835 R 585055 CDS YP_002404498.1 218696831 7146262 complement(3627755..3628525) 1 NC_011748.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase 3628525 garL 7146262 garL Escherichia coli 55989 alpha-dehydro-beta-deoxy-D-glucarate aldolase YP_002404498.1 3627755 R 585055 CDS YP_002404499.1 218696832 7146260 complement(3628541..3629875) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278, 9772162; Product type pt : transporter; (D)-galactarate transporter 3629875 garP 7146260 garP Escherichia coli 55989 (D)-galactarate transporter YP_002404499.1 3628541 R 585055 CDS YP_002404500.1 218696833 7146261 3630249..3631820 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 66096392, 81027430, 9772162, 10762278, 2407727; Product type e : enzyme; (D)-galactarate dehydrogenase 3631820 garD 7146261 garD Escherichia coli 55989 (D)-galactarate dehydrogenase YP_002404500.1 3630249 D 585055 CDS YP_002404501.1 218696834 7146258 3631969..3632304 1 NC_011748.1 SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; regulator PrlF 3632304 sohA 7146258 sohA Escherichia coli 55989 regulator PrlF YP_002404501.1 3631969 D 585055 CDS YP_002404502.1 218696835 7147674 3632304..3632768 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3632768 yhaV 7147674 yhaV Escherichia coli 55989 hypothetical protein YP_002404502.1 3632304 D 585055 CDS YP_002404503.1 218696836 7148924 complement(3632823..3633632) 1 NC_011748.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR 3633632 agaR 7148924 agaR Escherichia coli 55989 DNA-binding transcriptional regulator AgaR YP_002404503.1 3632823 R 585055 CDS YP_002404504.1 218696837 7145470 3633881..3635161 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976750, 20392444, 10931310, 8932697; Product type e : enzyme; tagatose 6-phosphate aldolase 1, kbaZ subunit 3635161 kbaZ 7145470 kbaZ Escherichia coli 55989 tagatose 6-phosphate aldolase 1, kbaZ subunit YP_002404504.1 3633881 D 585055 CDS YP_002404505.1 218696838 7146648 3635184..3635657 1 NC_011748.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3635657 agaV 7146648 agaV Escherichia coli 55989 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_002404505.1 3635184 D 585055 CDS YP_002404506.1 218696839 7145472 3635668..3636447 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; enzyme IIC component of PTS 3636447 7145472 EC55989_3552 Escherichia coli 55989 enzyme IIC component of PTS YP_002404506.1 3635668 D 585055 CDS YP_002404507.1 218696840 7145002 3636431..3637315 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; hexose/hexosamine family PTS permease IID component 3637315 7145002 EC55989_3553 Escherichia coli 55989 hexose/hexosamine family PTS permease IID component YP_002404507.1 3636431 D 585055 CDS YP_002404508.1 218696841 7145003 3637333..3637767 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; phosphotransferase system enzyme subunit (N-acetyl-galactosamine / galactosamine PTS system enzyme IIA component) 3637767 7145003 EC55989_3554 Escherichia coli 55989 phosphotransferase system enzyme subunit (N-acetyl-galactosamine / galactosamine PTS system enzyme IIA component) YP_002404508.1 3637333 D 585055 CDS YP_002404509.1 218696842 7145004 3637743..3638897 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; N-acetylglucosamine-6-phosphate deacetylase (GlcNAc 6-P deacetylase) 3638897 agaA 7145004 agaA Escherichia coli 55989 N-acetylglucosamine-6-phosphate deacetylase (GlcNAc 6-P deacetylase) YP_002404509.1 3637743 D 585055 CDS YP_002404510.1 218696843 7145465 3639247..3640401 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689210, 9697096, 14731281, 8932697; Product type e : enzyme; tagatose-6-phosphate ketose/aldose isomerase 3640401 agaS 7145465 agaS Escherichia coli 55989 tagatose-6-phosphate ketose/aldose isomerase YP_002404510.1 3639247 D 585055 CDS YP_002404511.1 218696844 7145471 3640414..3641274 1 NC_011748.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3641274 kbaY 7145471 kbaY Escherichia coli 55989 tagatose-bisphosphate aldolase YP_002404511.1 3640414 D 585055 CDS YP_002404512.1 218696845 7146647 3641441..3641917 1 NC_011748.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3641917 agaB 7146647 agaB Escherichia coli 55989 PTS system N-acetylgalactosamine-specific transporter subunit IIB YP_002404512.1 3641441 D 585055 CDS YP_002404513.1 218696846 7145466 3641956..3642759 1 NC_011748.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIC 3642759 agaC 7145466 agaC Escherichia coli 55989 PTS system N-acetylgalactosamine-specific transporter subunit IIC YP_002404513.1 3641956 D 585055 CDS YP_002404514.1 218696847 7145467 3642749..3643540 1 NC_011748.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 3643540 agaD 7145467 agaD Escherichia coli 55989 PTS system N-acetylgalactosamine-specific transporter subunit IID YP_002404514.1 3642749 D 585055 CDS YP_002404515.1 218696848 7145468 3643541..3644296 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10931310; Product type e : enzyme; galactosamine-6-phosphate isomerase 3644296 agaI 7145468 agaI Escherichia coli 55989 galactosamine-6-phosphate isomerase YP_002404515.1 3643541 D 585055 CDS YP_002404516.1 218696849 7145469 3644696..3645280 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 3645280 yraH 7145469 yraH Escherichia coli 55989 fimbrial-like adhesin protein YP_002404516.1 3644696 D 585055 CDS YP_002404517.1 218696850 7149436 3645360..3646055 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 11677609; Product type f : factor; periplasmic pilin chaperone (lpfB-like) 3646055 yraI 7149436 yraI Escherichia coli 55989 periplasmic pilin chaperone (lpfB-like) YP_002404517.1 3645360 D 585055 CDS YP_002404518.1 218696851 7149437 3646085..3648601 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; outer membrane protein 3648601 yraJ 7149437 yraJ Escherichia coli 55989 outer membrane protein YP_002404518.1 3646085 D 585055 CDS YP_002404519.1 218696852 7149438 3648612..3649703 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein (lpfD-like) 3649703 yraK 7149438 yraK Escherichia coli 55989 fimbrial-like adhesin protein (lpfD-like) YP_002404519.1 3648612 D 585055 CDS YP_002404520.1 218696853 7149439 complement(3649746..3650606) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; methyltransferase 3650606 yraL 7149439 yraL Escherichia coli 55989 methyltransferase YP_002404520.1 3649746 R 585055 CDS YP_002404521.1 218696854 7149440 3650670..3652706 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3652706 yraM 7149440 yraM Escherichia coli 55989 hypothetical protein YP_002404521.1 3650670 D 585055 CDS YP_002404522.1 218696855 7149441 3652664..3653059 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3653059 yraN 7149441 yraN Escherichia coli 55989 hypothetical protein YP_002404522.1 3652664 D 585055 CDS YP_002404523.1 218696856 7149442 3653079..3653669 1 NC_011748.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3653669 yraO 7149442 yraO Escherichia coli 55989 DnaA initiator-associating protein DiaA YP_002404523.1 3653079 D 585055 CDS YP_002404524.1 218696857 7149443 3653679..3654254 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3654254 ecfH 7149443 ecfH Escherichia coli 55989 hypothetical protein YP_002404524.1 3653679 D 585055 CDS YP_002404525.1 218696858 7145970 complement(3654368..3655408) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; permease 3655408 yraQ 7145970 yraQ Escherichia coli 55989 permease YP_002404525.1 3654368 R 585055 CDS YP_002404526.1 218696859 7149444 complement(3655481..3656116) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; nucleoside-diphosphate-sugar epimerase 3656116 yraR 7149444 yraR Escherichia coli 55989 nucleoside-diphosphate-sugar epimerase YP_002404526.1 3655481 R 585055 CDS YP_002404527.1 218696860 7149445 3656244..3656762 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; intracellular protease 3656762 yhbO 7149445 yhbO Escherichia coli 55989 intracellular protease YP_002404527.1 3656244 D 585055 CDS YP_002404528.1 218696861 7148929 complement(3656742..3657185) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3657185 yhbP 7148929 yhbP Escherichia coli 55989 hypothetical protein YP_002404528.1 3656742 R 585055 CDS YP_002404529.1 218696862 7148930 3657236..3657538 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; GIY-YIG nuclease superfamily protein 3657538 yhbQ 7148930 yhbQ Escherichia coli 55989 GIY-YIG nuclease superfamily protein YP_002404529.1 3657236 D 585055 CDS YP_002404530.1 218696863 7148931 complement(3657525..3658028) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acyltransferase with acyl-CoA N-acyltransferase domain 3658028 yhbS 7148931 yhbS Escherichia coli 55989 acyltransferase with acyl-CoA N-acyltransferase domain YP_002404530.1 3657525 R 585055 CDS YP_002404531.1 218696864 7148932 complement(3658022..3658546) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; lipid carrier protein 3658546 yhbT 7148932 yhbT Escherichia coli 55989 lipid carrier protein YP_002404531.1 3658022 R 585055 CDS YP_002404532.1 218696865 7148933 3658755..3659750 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; peptidase (collagenase-like) 3659750 yhbU 7148933 yhbU Escherichia coli 55989 peptidase (collagenase-like) YP_002404532.1 3658755 D 585055 CDS YP_002404533.1 218696866 7148934 3659759..3660637 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; protease 3660637 yhbV 7148934 yhbV Escherichia coli 55989 protease YP_002404533.1 3659759 D 585055 CDS YP_002404534.1 218696867 7148935 3660843..3661850 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 3661850 yhbW 7148935 yhbW Escherichia coli 55989 hypothetical protein YP_002404534.1 3660843 D 585055 CDS YP_002404535.1 218696868 7148936 complement(3661968..3663212) 1 NC_011748.1 tryptophan transporter of high affinity; tryptophan permease 3663212 mtr 7148936 mtr Escherichia coli 55989 tryptophan permease YP_002404535.1 3661968 R 585055 CDS YP_002404536.1 218696869 7146917 complement(3663366..3665255) 1 NC_011748.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD 3665255 deaD 7146917 deaD Escherichia coli 55989 ATP-dependent RNA helicase DeaD YP_002404536.1 3663366 R 585055 CDS YP_002404537.1 218696870 7145875 complement(3665435..3666319) 1 NC_011748.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI 3666319 nlpI 7145875 nlpI Escherichia coli 55989 lipoprotein NlpI YP_002404537.1 3665435 R 585055 CDS YP_002404538.1 218696871 7147011 complement(3666428..3668632) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87083499, 91198209, 99234021, 99340204, 2432069, 3005122, 6382163, 9008164, 9298646; Product type e : enzyme; polynucleotide phosphorylase 3668632 pnp 7147011 pnp Escherichia coli 55989 polynucleotide phosphorylase YP_002404538.1 3666428 R 585055 CDS YP_002404539.1 218696872 7147701 complement(3668810..3669079) 1 NC_011748.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 3669079 rpsO 7147701 rpsO Escherichia coli 55989 30S ribosomal protein S15 YP_002404539.1 3668810 R 585055 CDS YP_002404540.1 218696873 7147519 complement(3669228..3670172) 1 NC_011748.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B 3670172 truB 7147519 truB Escherichia coli 55989 tRNA pseudouridine synthase B YP_002404540.1 3669228 R 585055 CDS YP_002404541.1 218696874 7147859 complement(3670172..3670573) 1 NC_011748.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A 3670573 rbfA 7147859 rbfA Escherichia coli 55989 ribosome-binding factor A YP_002404541.1 3670172 R 585055 CDS YP_002404542.1 218696875 7147339 complement(3670737..3673409) 1 NC_011748.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 3673409 infB 7147339 infB Escherichia coli 55989 translation initiation factor IF-2 YP_002404542.1 3670737 R 585055 CDS YP_002404543.1 218696876 7146566 complement(3673434..3674921) 1 NC_011748.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA 3674921 nusA 7146566 nusA Escherichia coli 55989 transcription elongation factor NusA YP_002404543.1 3673434 R 585055 CDS YP_002404544.1 218696877 7147058 complement(3674949..3675401) 1 NC_011748.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein 3675401 yhbC 7147058 yhbC Escherichia coli 55989 hypothetical protein YP_002404544.1 3674949 R 585055 CDS YP_002404545.1 218696878 7145378 3676032..3677375 1 NC_011748.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3677375 argG 7145378 argG Escherichia coli 55989 argininosuccinate synthase YP_002404545.1 3676032 D 585055 CDS YP_002404546.1 218696879 7145529 complement(3677383..3679008) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase, inner membrane 3679008 yhbX 7145529 yhbX Escherichia coli 55989 hydrolase, inner membrane YP_002404546.1 3677383 R 585055 CDS YP_002404547.1 218696880 7145377 complement(3679566..3679898) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20194819, 21125563, 9020118, 94074540, 9564033, 9644254, 9829959, 99298179, 7556084, 8034620, 8045257, 8244950, 8253068; Product type t : transporter; preprotein translocase subunit SecG 3679898 secG 7145377 secG Escherichia coli 55989 preprotein translocase subunit SecG YP_002404547.1 3679566 R 585055 CDS YP_002404548.1 218696881 7147625 complement(3680126..3681463) 1 NC_011748.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase 3681463 glmM 7147625 glmM Escherichia coli 55989 phosphoglucosamine mutase YP_002404548.1 3680126 R 585055 CDS YP_002404549.1 218696882 7146299 complement(3681456..3682304) 1 NC_011748.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase 3682304 folP 7146299 folP Escherichia coli 55989 dihydropteroate synthase YP_002404549.1 3681456 R 585055 CDS YP_002404550.1 218696883 7146175 complement(3682394..3684328) 1 NC_011748.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease 3684328 hflB 7146175 hflB Escherichia coli 55989 ATP-dependent metalloprotease YP_002404550.1 3682394 R 585055 CDS YP_002404551.1 218696884 7146213 complement(3684428..3685057) 1 NC_011748.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase 3685057 rrmJ 7146213 rrmJ Escherichia coli 55989 23S rRNA methyltransferase YP_002404551.1 3684428 R 585055 CDS YP_002404552.1 218696885 7147528 3685183..3685476 1 NC_011748.1 RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3685476 yhbY 7147528 yhbY Escherichia coli 55989 RNA-binding protein YhbY YP_002404552.1 3685183 D 585055 CDS YP_002404553.1 218696886 7148938 complement(3685632..3686108) 1 NC_011748.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA 3686108 greA 7148938 greA Escherichia coli 55989 transcription elongation factor GreA YP_002404553.1 3685632 R 585055 CDS YP_002404554.1 218696887 7146365 3686356..3687789 1 NC_011748.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 3687789 dacB 7146365 dacB Escherichia coli 55989 D-alanyl-D-alanine carboxypeptidase YP_002404554.1 3686356 D 585055 CDS YP_002404555.1 218696888 7145842 complement(3687829..3689001) 1 NC_011748.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE 3689001 obgE 7145842 obgE Escherichia coli 55989 GTPase ObgE YP_002404555.1 3687829 R 585055 CDS YP_002404556.1 218696889 7147063 complement(3689017..3689982) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3689982 yhbE 7147063 yhbE Escherichia coli 55989 inner membrane protein YP_002404556.1 3689017 R 585055 CDS YP_002404557.1 218696890 7148926 complement(3690109..3690366) 1 NC_011748.1 involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 3690366 rpmA 7148926 rpmA Escherichia coli 55989 50S ribosomal protein L27 YP_002404557.1 3690109 R 585055 CDS YP_002404558.1 218696891 7147486 complement(3690387..3690698) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91088242, 94146411, 10094780, 387076, 8312607; Product type s : structure; 50S ribosomal protein L21 3690698 rplU 7147486 rplU Escherichia coli 55989 50S ribosomal protein L21 YP_002404558.1 3690387 R 585055 CDS YP_002404559.1 218696892 7147481 3690957..3691928 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94311902, 97284515, 2670911, 8037730, 8312607; Product type e : enzyme; octaprenyl diphosphate synthase 3691928 ispB 7147481 ispB Escherichia coli 55989 octaprenyl diphosphate synthase YP_002404559.1 3690957 D 585055 CDS YP_002404560.1 218696893 7146626 3692156..3692434 1 NC_011748.1 activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3692434 sfsB 7146626 sfsB Escherichia coli 55989 DNA-binding transcriptional regulator Nlp YP_002404560.1 3692156 D 585055 CDS YP_002404561.1 218696894 7147646 complement(3692482..3693741) 1 NC_011748.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase 3693741 murA 7147646 murA Escherichia coli 55989 UDP-N-acetylglucosamine 1-carboxyvinyltransferase YP_002404561.1 3692482 R 585055 CDS YP_002404562.1 218696895 7146921 complement(3693796..3694050) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 3694050 yrbA 7146921 yrbA Escherichia coli 55989 DNA-binding transcriptional regulator YP_002404562.1 3693796 R 585055 CDS YP_002404563.1 218696896 7149446 complement(3694210..3694503) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3694503 yrbB 7149446 yrbB Escherichia coli 55989 hypothetical protein YP_002404563.1 3694210 R 585055 CDS YP_002404564.1 218696897 7149447 complement(3694503..3695138) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene transporter subunit: membrane component of ABC superfamily 3695138 yrbC 7149447 yrbC Escherichia coli 55989 toluene transporter subunit: membrane component of ABC superfamily YP_002404564.1 3694503 R 585055 CDS YP_002404565.1 218696898 7149448 complement(3695157..3695708) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene transporter subunit: membrane component of ABC superfamily 3695708 yrbD 7149448 yrbD Escherichia coli 55989 toluene transporter subunit: membrane component of ABC superfamily YP_002404565.1 3695157 R 585055 CDS YP_002404566.1 218696899 7149449 complement(3695713..3696495) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene transporter subunit: membrane component of ABC superfamily 3696495 yrbE 7149449 yrbE Escherichia coli 55989 toluene transporter subunit: membrane component of ABC superfamily YP_002404566.1 3695713 R 585055 CDS YP_002404567.1 218696900 7149450 complement(3696503..3697312) 1 NC_011748.1 ATP-binding subunit of a ABC toluene efflux transporter; ABC transporter ATP-binding protein 3697312 yrbF 7149450 yrbF Escherichia coli 55989 ABC transporter ATP-binding protein YP_002404567.1 3696503 R 585055 CDS YP_002404568.1 218696901 7149451 3697522..3698499 1 NC_011748.1 YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; calcium/sodium:proton antiporter 3698499 yrbG 7149451 yrbG Escherichia coli 55989 calcium/sodium:proton antiporter YP_002404568.1 3697522 D 585055 CDS YP_002404569.1 218696902 7149452 3698513..3699499 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12805358; Product type e : enzyme; D-arabinose 5-phosphate isomerase 3699499 kdsD 7149452 kdsD Escherichia coli 55989 D-arabinose 5-phosphate isomerase YP_002404569.1 3698513 D 585055 CDS YP_002404570.1 218696903 7146662 3699520..3700086 1 NC_011748.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3700086 kdsC 7146662 kdsC Escherichia coli 55989 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase YP_002404570.1 3699520 D 585055 CDS YP_002404571.1 218696904 7146661 3700083..3700658 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3700658 yrbK 7146661 yrbK Escherichia coli 55989 hypothetical protein YP_002404571.1 3700083 D 585055 CDS YP_002404572.1 218696905 7149453 3700627..3701184 1 NC_011748.1 LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3701184 lptA 7149453 lptA Escherichia coli 55989 lipopolysaccharide transport periplasmic protein LptA YP_002404572.1 3700627 D 585055 CDS YP_002404573.1 218696906 7146733 3701191..3701916 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7876255, 9298646, 17056748; Product type pt : transporter; ABC transporter ATP-binding protein 3701916 lptB 7146733 lptB Escherichia coli 55989 ABC transporter ATP-binding protein YP_002404573.1 3701191 D 585055 CDS YP_002404574.1 218696907 7146734 3701964..3703397 1 NC_011748.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3703397 rpoN 7146734 rpoN Escherichia coli 55989 RNA polymerase factor sigma-54 YP_002404574.1 3701964 D 585055 CDS YP_002404575.1 218696908 7147501 3703420..3703707 1 NC_011748.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; sigma(54) modulation protein 3703707 yhbH 7147501 yhbH Escherichia coli 55989 sigma(54) modulation protein YP_002404575.1 3703420 D 585055 CDS YP_002404576.1 218696909 7148927 3703825..3704316 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88212176, 90136533, 90274974, 95020584, 95181483, 7876255, 8025669, 8444818, 9636714; Product type t : transporter; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 3704316 ptsN 7148927 ptsN Escherichia coli 55989 PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN YP_002404576.1 3703825 D 585055 CDS YP_002404577.1 218696910 7147290 3704362..3705216 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3705216 yhbJ 7147290 yhbJ Escherichia coli 55989 hypothetical protein YP_002404577.1 3704362 D 585055 CDS YP_002404578.1 218696911 7148928 3705213..3705485 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 95181483, 7876255, 8025669; Product type t : transporter; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3705485 npr 7148928 npr Escherichia coli 55989 phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) YP_002404578.1 3705213 D 585055 CDS YP_002404579.1 218696912 7147017 3705698..3706330 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 89083480; hypothetical protein 3706330 yrbL 7147017 yrbL Escherichia coli 55989 hypothetical protein YP_002404579.1 3705698 D 585055 CDS YP_002404580.1 218696913 7149454 complement(3706327..3707055) 1 NC_011748.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase 3707055 mtgA 7149454 mtgA Escherichia coli 55989 monofunctional biosynthetic peptidoglycan transglycosylase YP_002404580.1 3706327 R 585055 CDS YP_002404581.1 218696914 7146913 complement(3707052..3707705) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92246944, 98269038, 1575737, 9603997; Product type pe : enzyme; isoprenoid biosynthesis protein with amidotransferase-like domain 3707705 elbB 7146913 elbB Escherichia coli 55989 isoprenoid biosynthesis protein with amidotransferase-like domain YP_002404581.1 3707052 R 585055 CDS YP_002404582.1 218696915 7147591 complement(3707935..3710271) 1 NC_011748.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB 3710271 arcB 7147591 arcB Escherichia coli 55989 aerobic respiration control sensor protein ArcB YP_002404582.1 3707935 R 585055 CDS YP_002404583.1 218696916 7145523 complement(3710367..3711296) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; Fe-S oxidoreductase 3711296 yhcC 7145523 yhcC Escherichia coli 55989 Fe-S oxidoreductase YP_002404583.1 3710367 R 585055 CDS YP_002404584.1 218696917 7148940 3711878..3716431 1 NC_011748.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3716431 gltB 7148940 gltB Escherichia coli 55989 glutamate synthase subunit alpha YP_002404584.1 3711878 D 585055 CDS YP_002404585.1 218696918 7146328 3716444..3717862 1 NC_011748.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3717862 gltD 7146328 gltD Escherichia coli 55989 glutamate synthase subunit beta YP_002404585.1 3716444 D 585055 CDS YP_002404586.1 218696919 7148941 3718506..3718847 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3718847 7148941 EC55989_3633 Escherichia coli 55989 hypothetical protein YP_002404586.1 3718506 D 585055 CDS YP_002404587.1 218696920 7145005 complement(3718923..3719387) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3719387 yhcH 7145005 yhcH Escherichia coli 55989 hypothetical protein YP_002404587.1 3718923 R 585055 CDS YP_002404588.1 218696921 7148942 complement(3719384..3720259) 1 NC_011748.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase 3720259 nanK 7148942 nanK Escherichia coli 55989 N-acetylmannosamine kinase YP_002404588.1 3719384 R 585055 CDS YP_002404589.1 218696922 7146957 complement(3720256..3720945) 1 NC_011748.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 3720945 nanE 7146957 nanE Escherichia coli 55989 N-acetylmannosamine-6-phosphate 2-epimerase YP_002404589.1 3720256 R 585055 CDS YP_002404590.1 218696923 7146955 complement(3720993..3722483) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96011396, 9864311, 7592358; Product type t : transporter; sialic acid transporter 3722483 nanT 7146955 nanT Escherichia coli 55989 sialic acid transporter YP_002404590.1 3720993 R 585055 CDS YP_002404591.1 218696924 7146959 complement(3722592..3723485) 1 NC_011748.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase 3723485 nanA 7146959 nanA Escherichia coli 55989 N-acetylneuraminate lyase YP_002404591.1 3722592 R 585055 CDS YP_002404592.1 218696925 7146954 complement(3723607..3724398) 1 NC_011748.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR 3724398 nanR 7146954 nanR Escherichia coli 55989 transcriptional regulator NanR YP_002404592.1 3723607 R 585055 CDS YP_002404593.1 218696926 7146958 3724778..3726145 1 NC_011748.1 YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; cryptic C4-dicarboxylate transporter DcuD 3726145 dcuD 7146958 dcuD Escherichia coli 55989 cryptic C4-dicarboxylate transporter DcuD YP_002404593.1 3724778 D 585055 CDS YP_002404594.1 218696927 7145863 complement(3726188..3726685) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12445774, 94293773, 1721886, 3029697, 8022275; Product type f : factor; ClpXP protease specificity-enhancing factor 3726685 sspB 7145863 sspB Escherichia coli 55989 ClpXP protease specificity-enhancing factor YP_002404594.1 3726188 R 585055 CDS YP_002404595.1 218696928 7147715 complement(3726691..3727329) 1 NC_011748.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A 3727329 sspA 7147715 sspA Escherichia coli 55989 stringent starvation protein A YP_002404595.1 3726691 R 585055 CDS YP_002404596.1 218696929 7147714 complement(3727724..3728116) 1 NC_011748.1 forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 3728116 rpsI 7147714 rpsI Escherichia coli 55989 30S ribosomal protein S9 YP_002404596.1 3727724 R 585055 CDS YP_002404597.1 218696930 7147513 complement(3728132..3728560) 1 NC_011748.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 3728560 rplM 7147513 rplM Escherichia coli 55989 50S ribosomal protein L13 YP_002404597.1 3728132 R 585055 CDS YP_002404598.1 218696931 7147473 complement(3728779..3729906) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; nucleoside triphosphate hydrolase domain 3729906 yhcM 7147473 yhcM Escherichia coli 55989 nucleoside triphosphate hydrolase domain YP_002404598.1 3728779 R 585055 CDS YP_002404599.1 218696932 7148943 3730100..3730498 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type pe : enzyme; cytochrome d ubiquinol oxidase subunit III 3730498 yhcB 7148943 yhcB Escherichia coli 55989 cytochrome d ubiquinol oxidase subunit III YP_002404599.1 3730100 D 585055 CDS YP_002404600.1 218696933 7148939 3730652..3732019 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8830688, 96165272, 8576051, 8576052, 9740056; Product type e : enzyme; serine endoprotease 3732019 degQ 7148939 degQ Escherichia coli 55989 serine endoprotease YP_002404600.1 3730652 D 585055 CDS YP_002404601.1 218696934 7145880 3732109..3733176 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15137941, 15225661, 21352996, 96165272, 99431977, 3322223, 8576051; Product type e : enzyme; serine endoprotease 3733176 degS 7145880 degS Escherichia coli 55989 serine endoprotease YP_002404601.1 3732109 D 585055 CDS YP_002404602.1 218696935 7145881 complement(3733239..3734177) 1 NC_011748.1 oxidizes malate to oxaloacetate; malate dehydrogenase 3734177 mdh 7145881 mdh Escherichia coli 55989 malate dehydrogenase YP_002404602.1 3733239 R 585055 CDS YP_002404603.1 218696936 7146794 3734612..3735082 1 NC_011748.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 3735082 argR 7146794 argR Escherichia coli 55989 arginine repressor ArgR YP_002404603.1 3734612 D 585055 CDS YP_002404604.1 218696937 7145535 3735447..3735710 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3735710 yhcN 7145535 yhcN Escherichia coli 55989 hypothetical protein YP_002404604.1 3735447 D 585055 CDS YP_002404605.1 218696938 7148944 complement(3735766..3736038) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; barnase inhibitor 3736038 yhcO 7148944 yhcO Escherichia coli 55989 barnase inhibitor YP_002404605.1 3735766 R 585055 CDS YP_002404606.1 218696939 7148945 complement(3736130..3738097) 1 NC_011748.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB 3738097 aaeB 7148945 aaeB Escherichia coli 55989 p-hydroxybenzoic acid efflux subunit AaeB YP_002404606.1 3736130 R 585055 CDS YP_002404607.1 218696940 7145413 complement(3738103..3739035) 1 NC_011748.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA 3739035 aaeA 7145413 aaeA Escherichia coli 55989 p-hydroxybenzoic acid efflux subunit AaeA YP_002404607.1 3738103 R 585055 CDS YP_002404608.1 218696941 7145412 complement(3739043..3739246) 1 NC_011748.1 membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein 3739246 aaeX 7145412 aaeX Escherichia coli 55989 hypothetical protein YP_002404608.1 3739043 R 585055 CDS YP_002404609.1 218696942 7145415 3739429..3740358 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489430; Product type r : regulator; DNA-binding transcriptional regulator 3740358 aaeR 7145415 aaeR Escherichia coli 55989 DNA-binding transcriptional regulator YP_002404609.1 3739429 D 585055 CDS YP_002404610.1 218696943 7145414 complement(3740486..3741931) 1 NC_011748.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD 3741931 tldD 7145414 tldD Escherichia coli 55989 protease TldD YP_002404610.1 3740486 R 585055 CDS YP_002404611.1 218696944 7147806 complement(3742087..3745887) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10960106; Product type pm : membrane component; hypothetical protein 3745887 yhdP 7147806 yhdP Escherichia coli 55989 hypothetical protein YP_002404611.1 3742087 R 585055 CDS YP_002404612.1 218696945 7148951 complement(3745955..3747424) 1 NC_011748.1 involved in the processing of the 5'end of 16S rRNA; ribonuclease G 3747424 rng 7148951 rng Escherichia coli 55989 ribonuclease G YP_002404612.1 3745955 R 585055 CDS YP_002404613.1 218696946 7147449 complement(3747414..3748007) 1 NC_011748.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein 3748007 yhdE 7147449 yhdE Escherichia coli 55989 Maf-like protein YP_002404613.1 3747414 R 585055 CDS YP_002404614.1 218696947 7148946 complement(3748016..3748504) 1 NC_011748.1 part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD 3748504 mreD 7148946 mreD Escherichia coli 55989 rod shape-determining protein MreD YP_002404614.1 3748016 R 585055 CDS YP_002404615.1 218696948 7146904 complement(3748488..3748619) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 3748619 7146904 EC55989_3662 Escherichia coli 55989 hypothetical protein YP_002404615.1 3748488 R 585055 CDS YP_002404616.1 218696949 7145006 complement(3748504..3749607) 1 NC_011748.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC 3749607 mreC 7145006 mreC Escherichia coli 55989 rod shape-determining protein MreC YP_002404616.1 3748504 R 585055 CDS YP_002404617.1 218696950 7146903 complement(3749673..3750716) 1 NC_011748.1 functions in MreBCD complex in some organisms; rod shape-determining protein MreB 3750716 mreB 7146903 mreB Escherichia coli 55989 rod shape-determining protein MreB YP_002404617.1 3749673 R 585055 CDS YP_002404618.1 218696951 7146902 3750824..3751012 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 3751012 7146902 EC55989_3665 Escherichia coli 55989 hypothetical protein YP_002404618.1 3750824 D 585055 CDS YP_002404619.1 218696952 7145007 complement(3751021..3752961) 1 NC_011748.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD 3752961 csrD 7145007 csrD Escherichia coli 55989 regulatory protein CsrD YP_002404619.1 3751021 R 585055 CDS YP_002404620.1 218696953 7145786 3753113..3754087 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase, Zn-dependent and NAD(P)-binding 3754087 yhdH 7145786 yhdH Escherichia coli 55989 oxidoreductase, Zn-dependent and NAD(P)-binding YP_002404620.1 3753113 D 585055 CDS YP_002404621.1 218696954 7148947 3755065..3755535 1 NC_011748.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3755535 accB 7148947 accB Escherichia coli 55989 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit YP_002404621.1 3755065 D 585055 CDS YP_002404622.1 218696955 7145429 3755546..3756895 1 NC_011748.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3756895 accC 7145429 accC Escherichia coli 55989 acetyl-CoA carboxylase biotin carboxylase subunit YP_002404622.1 3755546 D 585055 CDS YP_002404623.1 218696956 7145430 3757004..3757246 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 3757246 yhdT 7145430 yhdT Escherichia coli 55989 hypothetical protein YP_002404623.1 3757004 D 585055 CDS YP_002404624.1 218696957 7148952 3757236..3758687 1 NC_011748.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3758687 panF 7148952 panF Escherichia coli 55989 sodium/panthothenate symporter YP_002404624.1 3757236 D 585055 CDS YP_002404625.1 218696958 7147114 3758699..3759580 1 NC_011748.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 3759580 prmA 7147114 prmA Escherichia coli 55989 50S ribosomal protein L11 methyltransferase YP_002404625.1 3758699 D 585055 CDS YP_002404626.1 218696959 7147249 3759909..3760874 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566, 1459953, 1547773, 2835774, 2837762, 8226664; Product type e : enzyme; tRNA-dihydrouridine synthase B 3760874 dusB 7147249 dusB Escherichia coli 55989 tRNA-dihydrouridine synthase B YP_002404626.1 3759909 D 585055 CDS YP_002404627.1 218696960 7145960 3760900..3761196 1 NC_011748.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3761196 fis 7145960 fis Escherichia coli 55989 DNA-binding protein Fis YP_002404627.1 3760900 D 585055 CDS YP_002404628.1 218696961 7146113 3761282..3762166 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15028690, 9073062; Product type e : enzyme; methyltransferase 3762166 yhdJ 7146113 yhdJ Escherichia coli 55989 methyltransferase YP_002404628.1 3761282 D 585055 CDS YP_002404629.1 218696962 7148948 3762250..3762429 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 3762429 yhdU 7148948 yhdU Escherichia coli 55989 hypothetical protein YP_002404629.1 3762250 D 585055 CDS YP_002404630.1 218696963 7148953 complement(3762432..3763094) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8203018, 11257026, 8407802, 1720861; Product type r : regulator; DNA-binding transcriptional regulator EnvR 3763094 envR 7148953 envR Escherichia coli 55989 DNA-binding transcriptional regulator EnvR YP_002404630.1 3762432 R 585055 CDS YP_002404631.1 218696964 7146006 3763493..3764650 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012493, 1720861; Product type lp : lipoprotein; hypothetical protein 3764650 acrE 7146006 acrE Escherichia coli 55989 hypothetical protein YP_002404631.1 3763493 D 585055 CDS YP_002404632.1 218696965 7145447 3764662..3767766 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94262163, 99449638, 1720861, 8407802; Product type t : transporter; multidrug efflux system protein 3767766 acrF 7145447 acrF Escherichia coli 55989 multidrug efflux system protein YP_002404632.1 3764662 D 585055 CDS YP_002404633.1 218696966 7145448 3768019..3768240 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; outer membrane protein 3768240 yhdV 7145448 yhdV Escherichia coli 55989 outer membrane protein YP_002404633.1 3768019 D 585055 CDS YP_002404634.1 218696967 7148954 3768466..3768642 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3768642 7148954 EC55989_3682 Escherichia coli 55989 hypothetical protein YP_002404634.1 3768466 D 585055 CDS YP_002404635.1 218696968 7145008 3768779..3769696 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid transporter subunit ; periplasmic-binding component of ABC superfamily 3769696 aapJ 7145008 aapJ Escherichia coli 55989 amino-acid transporter subunit ; periplasmic-binding component of ABC superfamily YP_002404635.1 3768779 D 585055 CDS YP_002404636.1 218696969 7145416 3769764..3770945 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid transporter subunit ; membrane component of ABC superfamily 3770945 aapQ 7145416 aapQ Escherichia coli 55989 amino-acid transporter subunit ; membrane component of ABC superfamily YP_002404636.1 3769764 D 585055 CDS YP_002404637.1 218696970 7145419 3770955..3772058 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid transporter subunit ; membrane component of ABC superfamily 3772058 aapM 7145419 aapM Escherichia coli 55989 amino-acid transporter subunit ; membrane component of ABC superfamily YP_002404637.1 3770955 D 585055 CDS YP_002404638.1 218696971 7145417 3772066..3772824 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8809753, 8898392; Product type t : transporter; amino-acid ABC transporter ATP-binding protein 3772824 aapP 7145417 aapP Escherichia coli 55989 amino-acid ABC transporter ATP-binding protein YP_002404638.1 3772066 D 585055 CDS YP_002404639.1 218696972 7144632 3778874..3779428 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3779428 yrdA 7144632 yrdA Escherichia coli 55989 hypothetical protein YP_002404639.1 3778874 D 585055 CDS YP_002404640.1 218696973 7149455 complement(3779404..3779661) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3779661 yrdB 7149455 yrdB Escherichia coli 55989 hypothetical protein YP_002404640.1 3779404 R 585055 CDS YP_002404641.1 218696974 7149456 complement(3779658..3780476) 1 NC_011748.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase 3780476 aroE 7149456 aroE Escherichia coli 55989 shikimate 5-dehydrogenase YP_002404641.1 3779658 R 585055 CDS YP_002404642.1 218696975 7145543 complement(3780481..3781053) 1 NC_011748.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; ribosome maturation factor 3781053 yrdC 7145543 yrdC Escherichia coli 55989 ribosome maturation factor YP_002404642.1 3780481 R 585055 CDS YP_002404643.1 218696976 7149457 complement(3781058..3781600) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; DNA topoisomerase 3781600 yrdD 7149457 yrdD Escherichia coli 55989 DNA topoisomerase YP_002404643.1 3781058 R 585055 CDS YP_002404644.1 218696977 7149458 complement(3781629..3782102) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8432722; hypothetical protein 3782102 smg 7149458 smg Escherichia coli 55989 hypothetical protein YP_002404644.1 3781629 R 585055 CDS YP_002404645.1 218696978 7147667 complement(3782074..3783198) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8112305, 8432722; DNA protecting protein DprA 3783198 smf 7147667 smf Escherichia coli 55989 DNA protecting protein DprA YP_002404645.1 3782074 R 585055 CDS YP_002404646.1 218696979 7147666 3783328..3783837 1 NC_011748.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3783837 def 7147666 def Escherichia coli 55989 peptide deformylase YP_002404646.1 3783328 D 585055 CDS YP_002404647.1 218696980 7145878 3783852..3784799 1 NC_011748.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3784799 fmt 7145878 fmt Escherichia coli 55989 methionyl-tRNA formyltransferase YP_002404647.1 3783852 D 585055 CDS YP_002404648.1 218696981 7146164 3784845..3786134 1 NC_011748.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase GidB 3786134 rsmB 7146164 rsmB Escherichia coli 55989 16S rRNA methyltransferase GidB YP_002404648.1 3784845 D 585055 CDS YP_002404649.1 218696982 7147535 3786156..3787532 1 NC_011748.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 3787532 trkA 7147535 trkA Escherichia coli 55989 potassium transporter peripheral membrane protein YP_002404649.1 3786156 D 585055 CDS YP_002404650.1 218696983 7147841 3787662..3788072 1 NC_011748.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 3788072 mscL 7147841 mscL Escherichia coli 55989 large-conductance mechanosensitive channel YP_002404650.1 3787662 D 585055 CDS YP_002404651.1 218696984 7146908 complement(3788069..3788287) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3788287 yhdL 7146908 yhdL Escherichia coli 55989 hypothetical protein YP_002404651.1 3788069 R 585055 CDS YP_002404652.1 218696985 7148949 complement(3788343..3788768) 1 NC_011748.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator 3788768 zntR 7148949 zntR Escherichia coli 55989 zinc-responsive transcriptional regulator YP_002404652.1 3788343 R 585055 CDS YP_002404653.1 218696986 7149491 complement(3788779..3789147) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3789147 yhdN 7149491 yhdN Escherichia coli 55989 hypothetical protein YP_002404653.1 3788779 R 585055 CDS YP_002404654.1 218696987 7148950 complement(3789254..3789637) 1 NC_011748.1 is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 3789637 rplQ 7148950 rplQ Escherichia coli 55989 50S ribosomal protein L17 YP_002404654.1 3789254 R 585055 CDS YP_002404655.1 218696988 7147477 complement(3789678..3790667) 1 NC_011748.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha 3790667 rpoA 7147477 rpoA Escherichia coli 55989 DNA-directed RNA polymerase subunit alpha YP_002404655.1 3789678 R 585055 CDS YP_002404656.1 218696989 7147495 complement(3790693..3791313) 1 NC_011748.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 3791313 rpsD 7147495 rpsD Escherichia coli 55989 30S ribosomal protein S4 YP_002404656.1 3790693 R 585055 CDS YP_002404657.1 218696990 7147508 complement(3791347..3791736) 1 NC_011748.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 3791736 rpsK 7147508 rpsK Escherichia coli 55989 30S ribosomal protein S11 YP_002404657.1 3791347 R 585055 CDS YP_002404658.1 218696991 7147515 complement(3791753..3792109) 1 NC_011748.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 3792109 rpsM 7147515 rpsM Escherichia coli 55989 30S ribosomal protein S13 YP_002404658.1 3791753 R 585055 CDS YP_002404659.1 218696992 7145313 complement(3792404..3793735) 1 NC_011748.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY 3793735 secY 7145313 secY Escherichia coli 55989 preprotein translocase subunit SecY YP_002404659.1 3792404 R 585055 CDS YP_002404660.1 218696993 7147627 complement(3793743..3794177) 1 NC_011748.1 late assembly protein; 50S ribosomal protein L15 3794177 rplO 7147627 rplO Escherichia coli 55989 50S ribosomal protein L15 YP_002404660.1 3793743 R 585055 CDS YP_002404661.1 218696994 7147475 complement(3794181..3794360) 1 NC_011748.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 3794360 rpmD 7147475 rpmD Escherichia coli 55989 50S ribosomal protein L30 YP_002404661.1 3794181 R 585055 CDS YP_002404662.1 218696995 7147489 complement(3794364..3794867) 1 NC_011748.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 3794867 rpsE 7147489 rpsE Escherichia coli 55989 30S ribosomal protein S5 YP_002404662.1 3794364 R 585055 CDS YP_002404663.1 218696996 7147509 complement(3794882..3795235) 1 NC_011748.1 binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 3795235 rplR 7147509 rplR Escherichia coli 55989 50S ribosomal protein L18 YP_002404663.1 3794882 R 585055 CDS YP_002404664.1 218696997 7147478 complement(3795245..3795778) 1 NC_011748.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 3795778 rplF 7147478 rplF Escherichia coli 55989 50S ribosomal protein L6 YP_002404664.1 3795245 R 585055 CDS YP_002404665.1 218696998 7147468 complement(3795791..3796183) 1 NC_011748.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 3796183 rpsH 7147468 rpsH Escherichia coli 55989 30S ribosomal protein S8 YP_002404665.1 3795791 R 585055 CDS YP_002404666.1 218696999 7147512 complement(3796217..3796522) 1 NC_011748.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 3796522 rpsN 7147512 rpsN Escherichia coli 55989 30S ribosomal protein S14 YP_002404666.1 3796217 R 585055 CDS YP_002404667.1 218697000 7147518 complement(3796537..3797076) 1 NC_011748.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 3797076 rplE 7147518 rplE Escherichia coli 55989 50S ribosomal protein L5 YP_002404667.1 3796537 R 585055 CDS YP_002404668.1 218697001 7147467 complement(3797091..3797405) 1 NC_011748.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 3797405 rplX 7147467 rplX Escherichia coli 55989 50S ribosomal protein L24 YP_002404668.1 3797091 R 585055 CDS YP_002404669.1 218697002 7147484 complement(3797416..3797787) 1 NC_011748.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 3797787 rplN 7147484 rplN Escherichia coli 55989 50S ribosomal protein L14 YP_002404669.1 3797416 R 585055 CDS YP_002404670.1 218697003 7147474 complement(3797952..3798206) 1 NC_011748.1 primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 3798206 rpsQ 7147474 rpsQ Escherichia coli 55989 30S ribosomal protein S17 YP_002404670.1 3797952 R 585055 CDS YP_002404671.1 218697004 7147521 complement(3798206..3798397) 1 NC_011748.1 one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 3798397 rpmC 7147521 rpmC Escherichia coli 55989 50S ribosomal protein L29 YP_002404671.1 3798206 R 585055 CDS YP_002404672.1 218697005 7147488 complement(3798397..3798807) 1 NC_011748.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 3798807 rplP 7147488 rplP Escherichia coli 55989 50S ribosomal protein L16 YP_002404672.1 3798397 R 585055 CDS YP_002404673.1 218697006 7147476 complement(3798820..3799521) 1 NC_011748.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 3799521 rpsC 7147476 rpsC Escherichia coli 55989 30S ribosomal protein S3 YP_002404673.1 3798820 R 585055 CDS YP_002404674.1 218697007 7147507 complement(3799539..3799871) 1 NC_011748.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 3799871 rplV 7147507 rplV Escherichia coli 55989 50S ribosomal protein L22 YP_002404674.1 3799539 R 585055 CDS YP_002404675.1 218697008 7147482 complement(3799886..3800164) 1 NC_011748.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 3800164 rpsS 7147482 rpsS Escherichia coli 55989 30S ribosomal protein S19 YP_002404675.1 3799886 R 585055 CDS YP_002404676.1 218697009 7147523 complement(3800181..3801002) 1 NC_011748.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 3801002 rplB 7147523 rplB Escherichia coli 55989 50S ribosomal protein L2 YP_002404676.1 3800181 R 585055 CDS YP_002404677.1 218697010 7147464 complement(3801020..3801322) 1 NC_011748.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 3801322 rplW 7147464 rplW Escherichia coli 55989 50S ribosomal protein L23 YP_002404677.1 3801020 R 585055 CDS YP_002404678.1 218697011 7147483 complement(3801319..3801924) 1 NC_011748.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 3801924 rplD 7147483 rplD Escherichia coli 55989 50S ribosomal protein L4 YP_002404678.1 3801319 R 585055 CDS YP_002404679.1 218697012 7147466 complement(3801935..3802564) 1 NC_011748.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 3802564 rplC 7147466 rplC Escherichia coli 55989 50S ribosomal protein L3 YP_002404679.1 3801935 R 585055 CDS YP_002404680.1 218697013 7147465 complement(3802597..3802908) 1 NC_011748.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 3802908 rpsJ 7147465 rpsJ Escherichia coli 55989 30S ribosomal protein S10 YP_002404680.1 3802597 R 585055 CDS YP_002404681.1 218697014 7147514 complement(3803037..3803198) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 3803198 7147514 EC55989_3738 Escherichia coli 55989 hypothetical protein YP_002404681.1 3803037 R 585055 CDS YP_002404682.1 218697015 7145009 3803287..3803754 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; bifunctional prepilin peptidase HopD: leader peptidase; methyl transferase (General Secretory Pathway) 3803754 7145009 EC55989_3739 Escherichia coli 55989 bifunctional prepilin peptidase HopD: leader peptidase; methyl transferase (General Secretory Pathway) YP_002404682.1 3803287 D 585055 CDS YP_002404683.1 218697016 7145010 complement(3803751..3804227) 1 NC_011748.1 iron storage protein; bacterioferritin 3804227 bfr 7145010 bfr Escherichia coli 55989 bacterioferritin YP_002404683.1 3803751 R 585055 CDS YP_002404684.1 218697017 7145615 complement(3804300..3804494) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8954950, 9889981, 2661540, 8639572; Product type c : carrier; bacterioferritin-associated ferredoxin 3804494 bfd 7145615 bfd Escherichia coli 55989 bacterioferritin-associated ferredoxin YP_002404684.1 3804300 R 585055 CDS YP_002404685.1 218697018 7145614 complement(3804677..3805861) 1 NC_011748.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 3805861 tufA 7145614 tufA Escherichia coli 55989 elongation factor Tu YP_002404685.1 3804677 R 585055 CDS YP_002404686.1 218697019 7147872 complement(3805932..3808046) 1 NC_011748.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G 3808046 fusA 7147872 fusA Escherichia coli 55989 elongation factor G YP_002404686.1 3805932 R 585055 CDS YP_002404687.1 218697020 7146234 complement(3808143..3808613) 1 NC_011748.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 3808613 rpsG 7146234 rpsG Escherichia coli 55989 30S ribosomal protein S7 YP_002404687.1 3808143 R 585055 CDS YP_002404688.1 218697021 7147511 complement(3808710..3809084) 1 NC_011748.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 3809084 rpsL 7147511 rpsL Escherichia coli 55989 30S ribosomal protein S12 YP_002404688.1 3808710 R 585055 CDS YP_002404689.1 218697022 7147516 complement(3809210..3809497) 1 NC_011748.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB 3809497 tusB 7147516 tusB Escherichia coli 55989 sulfur transfer complex subunit TusB YP_002404689.1 3809210 R 585055 CDS YP_002404690.1 218697023 7147876 complement(3809505..3809864) 1 NC_011748.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC 3809864 tusC 7147876 tusC Escherichia coli 55989 sulfur relay protein TusC YP_002404690.1 3809505 R 585055 CDS YP_002404691.1 218697024 7147877 complement(3809864..3810250) 1 NC_011748.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD 3810250 tusD 7147877 tusD Escherichia coli 55989 sulfur transfer complex subunit TusD YP_002404691.1 3809864 R 585055 CDS YP_002404692.1 218697025 7147878 complement(3810250..3810972) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 3810972 yheO 7147878 yheO Escherichia coli 55989 DNA-binding transcriptional regulator YP_002404692.1 3810250 R 585055 CDS YP_002404693.1 218697026 7148955 complement(3811139..3811951) 1 NC_011748.1 rotamase; FKBP-type peptidylprolyl isomerase 3811951 fkpA 7148955 fkpA Escherichia coli 55989 FKBP-type peptidylprolyl isomerase YP_002404693.1 3811139 R 585055 CDS YP_002404694.1 218697027 7146120 3812172..3812390 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3812390 slyX 7146120 slyX Escherichia coli 55989 hypothetical protein YP_002404694.1 3812172 D 585055 CDS YP_002404695.1 218697028 7147665 complement(3812439..3813029) 1 NC_011748.1 rotamase; FKBP-type peptidylprolyl isomerase 3813029 slyD 7147665 slyD Escherichia coli 55989 FKBP-type peptidylprolyl isomerase YP_002404695.1 3812439 R 585055 CDS YP_002404696.1 218697029 7147664 complement(3813124..3813324) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3813324 yheV 7147664 yheV Escherichia coli 55989 hypothetical protein YP_002404696.1 3813124 R 585055 CDS YP_002404697.1 218697030 7148959 complement(3813334..3815139) 1 NC_011748.1 involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB 3815139 kefB 7148959 kefB Escherichia coli 55989 glutathione-regulated potassium-efflux system protein KefB YP_002404697.1 3813334 R 585055 CDS YP_002404698.1 218697031 7146667 complement(3815139..3815693) 1 NC_011748.1 required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG 3815693 kefG 7146667 kefG Escherichia coli 55989 glutathione-regulated potassium-efflux system ancillary protein KefG YP_002404698.1 3815139 R 585055 CDS YP_002404699.1 218697032 7146670 3815821..3817734 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; ABC transporter ATP-binding protein 3817734 yheS 7146670 yheS Escherichia coli 55989 ABC transporter ATP-binding protein YP_002404699.1 3815821 D 585055 CDS YP_002404700.1 218697033 7148956 3817734..3818756 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9889164; Product type pe : enzyme; hydrolase 3818756 yheT 7148956 yheT Escherichia coli 55989 hydrolase YP_002404700.1 3817734 D 585055 CDS YP_002404701.1 218697034 7148957 3818750..3818968 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3818968 yheU 7148957 yheU Escherichia coli 55989 hypothetical protein YP_002404701.1 3818750 D 585055 CDS YP_002404702.1 218697035 7148958 3819022..3819891 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2559876; Product type e : enzyme; phosphoribulokinase 3819891 prkB 7148958 prkB Escherichia coli 55989 phosphoribulokinase YP_002404702.1 3819022 D 585055 CDS YP_002404703.1 218697036 7147247 complement(3819946..3820350) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3820350 yhfA 7147247 yhfA Escherichia coli 55989 hypothetical protein YP_002404703.1 3819946 R 585055 CDS YP_002404704.1 218697037 7145761 3820430..3820645 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3820645 7145761 EC55989_3762 Escherichia coli 55989 hypothetical protein YP_002404704.1 3820430 D 585055 CDS YP_002404705.1 218697038 7145011 3820652..3821284 1 NC_011748.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3821284 crp 7145011 crp Escherichia coli 55989 cAMP-regulatory protein YP_002404705.1 3820652 D 585055 CDS YP_002404706.1 218697039 7145760 3821323..3823425 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3823425 yhfK 7145760 yhfK Escherichia coli 55989 inner membrane protein YP_002404706.1 3821323 D 585055 CDS YP_002404707.1 218697040 7148962 complement(3823492..3824712) 1 NC_011748.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein 3824712 argD 7148962 argD Escherichia coli 55989 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein YP_002404707.1 3823492 R 585055 CDS YP_002404708.1 218697041 7145527 complement(3824798..3825361) 1 NC_011748.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II 3825361 pabA 7145527 pabA Escherichia coli 55989 para-aminobenzoate synthase component II YP_002404708.1 3824798 R 585055 CDS YP_002404709.1 218697042 7147106 complement(3825393..3825995) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92021789, 94095125, 2007139, 2403545, 2546924, 7549107; Product type cp : cell process; cell filamentation protein Fic 3825995 fic 7147106 fic Escherichia coli 55989 cell filamentation protein Fic YP_002404709.1 3825393 R 585055 CDS YP_002404710.1 218697043 7146107 complement(3825985..3826152) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3826152 yhfG 7146107 yhfG Escherichia coli 55989 hypothetical protein YP_002404710.1 3825985 R 585055 CDS YP_002404711.1 218697044 7148961 complement(3826257..3826829) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 2001362, 2007139, 2190212, 2403545, 2546924, 8130188, 8180197; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase A 3826829 ppiA 7148961 ppiA Escherichia coli 55989 peptidyl-prolyl cis-trans isomerase A YP_002404711.1 3826257 R 585055 CDS YP_002404712.1 218697045 7147228 3827100..3828281 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20509826; Product type pt : transporter; hypothetical protein 3828281 tsgA 7147228 tsgA Escherichia coli 55989 hypothetical protein YP_002404712.1 3827100 D 585055 CDS YP_002404713.1 218697046 7147866 3828543..3831086 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93062014, 2200672, 2445993, 2543955; Product type e : enzyme; nitrite reductase, large subunit, NAD(P) H-binding 3831086 nirB 7147866 nirB Escherichia coli 55989 nitrite reductase, large subunit, NAD(P) H-binding YP_002404713.1 3828543 D 585055 CDS YP_002404714.1 218697047 7147003 3831083..3831409 1 NC_011748.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3831409 nirD 7147003 nirD Escherichia coli 55989 nitrite reductase small subunit YP_002404714.1 3831083 D 585055 CDS YP_002404715.1 218697048 7147005 3831536..3832342 1 NC_011748.1 member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3832342 nirC 7147005 nirC Escherichia coli 55989 nitrite transporter NirC YP_002404715.1 3831536 D 585055 CDS YP_002404716.1 218697049 7147004 3832361..3833734 1 NC_011748.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3833734 cysG 7147004 cysG Escherichia coli 55989 siroheme synthase YP_002404716.1 3832361 D 585055 CDS YP_002404717.1 218697050 7145825 3833981..3834148 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; secreted peptide 3834148 yhfL 7145825 yhfL Escherichia coli 55989 secreted peptide YP_002404717.1 3833981 D 585055 CDS YP_002404718.1 218697051 7148963 3834443..3835780 1 NC_011748.1 inner membrane protein possibly involved in fructoselysine transport; member of the flr operon; fructoselysine transporter 3835780 frlA 7148963 frlA Escherichia coli 55989 fructoselysine transporter YP_002404718.1 3834443 D 585055 CDS YP_002404719.1 218697052 7146184 3835801..3836823 1 NC_011748.1 catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine; fructoselysine-6-P-deglycase 3836823 frlB 7146184 frlB Escherichia coli 55989 fructoselysine-6-P-deglycase YP_002404719.1 3835801 D 585055 CDS YP_002404720.1 218697053 7146185 3836873..3837703 1 NC_011748.1 YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine; fructoselysine 3-epimerase 3837703 frlC 7146185 frlC Escherichia coli 55989 fructoselysine 3-epimerase YP_002404720.1 3836873 D 585055 CDS YP_002404721.1 218697054 7146186 3837700..3838485 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12147680; Product type e : enzyme; fructoselysine 6-kinase 3838485 frlD 7146186 frlD Escherichia coli 55989 fructoselysine 6-kinase YP_002404721.1 3837700 D 585055 CDS YP_002404722.1 218697055 7146187 3838585..3839316 1 NC_011748.1 may act as a transcriptional regulator of a fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes; DNA-binding transcriptional regulator FrlR 3839316 frlR 7146187 frlR Escherichia coli 55989 DNA-binding transcriptional regulator FrlR YP_002404722.1 3838585 D 585055 CDS YP_002404723.1 218697056 7146188 complement(3839468..3840553) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3840553 yhfS 7146188 yhfS Escherichia coli 55989 hypothetical protein YP_002404723.1 3839468 R 585055 CDS YP_002404724.1 218697057 7148964 complement(3840565..3841869) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3841869 yhfT 7148964 yhfT Escherichia coli 55989 inner membrane protein YP_002404724.1 3840565 R 585055 CDS YP_002404725.1 218697058 7148965 complement(3841881..3842234) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3842234 yhfU 7148965 yhfU Escherichia coli 55989 hypothetical protein YP_002404725.1 3841881 R 585055 CDS YP_002404726.1 218697059 7148966 complement(3842245..3843123) 1 NC_011748.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); hydrolase 3843123 php 7148966 php Escherichia coli 55989 hydrolase YP_002404726.1 3842245 R 585055 CDS YP_002404727.1 218697060 7147187 complement(3843120..3844346) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; mutase 3844346 yhfW 7147187 yhfW Escherichia coli 55989 mutase YP_002404727.1 3843120 R 585055 CDS YP_002404728.1 218697061 7148967 complement(3844346..3845509) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; amino acid racemase 3845509 yhfX 7148967 yhfX Escherichia coli 55989 amino acid racemase YP_002404728.1 3844346 R 585055 CDS YP_002404729.1 218697062 7148968 complement(3845593..3845955) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3845955 yhfY 7148968 yhfY Escherichia coli 55989 hypothetical protein YP_002404729.1 3845593 R 585055 CDS YP_002404730.1 218697063 7148969 complement(3845972..3846877) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3846877 yhfZ 7148969 yhfZ Escherichia coli 55989 hypothetical protein YP_002404730.1 3845972 R 585055 CDS YP_002404731.1 218697064 7148970 complement(3847146..3848150) 1 NC_011748.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase 3848150 trpS 7148970 trpS Escherichia coli 55989 tryptophanyl-tRNA synthetase YP_002404731.1 3847146 R 585055 CDS YP_002404732.1 218697065 7147857 complement(3848143..3848901) 1 NC_011748.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase 3848901 gph 7147857 gph Escherichia coli 55989 phosphoglycolate phosphatase YP_002404732.1 3848143 R 585055 CDS YP_002404733.1 218697066 7146359 complement(3848894..3849571) 1 NC_011748.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase 3849571 rpe 7146359 rpe Escherichia coli 55989 ribulose-phosphate 3-epimerase YP_002404733.1 3848894 R 585055 CDS YP_002404734.1 218697067 7147460 complement(3849589..3850425) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90136529, 92262475, 92272672, 2549371, 6300769, 7603433, 8341592; Product type e : enzyme; DNA adenine methylase 3850425 dam 7147460 dam Escherichia coli 55989 DNA adenine methylase YP_002404734.1 3849589 R 585055 CDS YP_002404735.1 218697068 7145847 complement(3850532..3851818) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3851818 damX 7145847 damX Escherichia coli 55989 hypothetical protein YP_002404735.1 3850532 R 585055 CDS YP_002404736.1 218697069 7145848 complement(3851910..3852998) 1 NC_011748.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase 3852998 aroB 7145848 aroB Escherichia coli 55989 3-dehydroquinate synthase YP_002404736.1 3851910 R 585055 CDS YP_002404737.1 218697070 7145540 complement(3853055..3853576) 1 NC_011748.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I 3853576 aroK 7145540 aroK Escherichia coli 55989 shikimate kinase I YP_002404737.1 3853055 R 585055 CDS YP_002404738.1 218697071 7145547 complement(3853977..3855215) 1 NC_011748.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ 3855215 hofQ 7145547 hofQ Escherichia coli 55989 outer membrane porin HofQ YP_002404738.1 3853977 R 585055 CDS YP_002404739.1 218697072 7146451 complement(3855127..3855531) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3855531 yrfA 7146451 yrfA Escherichia coli 55989 hypothetical protein YP_002404739.1 3855127 R 585055 CDS YP_002404740.1 218697073 7149459 complement(3855521..3855961) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 3855961 yrfB 7149459 yrfB Escherichia coli 55989 hypothetical protein YP_002404740.1 3855521 R 585055 CDS YP_002404741.1 218697074 7149460 complement(3855945..3856484) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial assembly protein (pilN-like) 3856484 yrfC 7149460 yrfC Escherichia coli 55989 fimbrial assembly protein (pilN-like) YP_002404741.1 3855945 R 585055 CDS YP_002404742.1 218697075 7149461 complement(3856484..3857263) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; pilus assembly protein 3857263 yrfD 7149461 yrfD Escherichia coli 55989 pilus assembly protein YP_002404742.1 3856484 R 585055 CDS YP_002404743.1 218697076 7149462 3857383..3859935 1 NC_011748.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 3859935 mrcA 7149462 mrcA Escherichia coli 55989 peptidoglycan synthetase YP_002404743.1 3857383 D 585055 CDS YP_002404744.1 218697077 7146898 complement(3860103..3860663) 1 NC_011748.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE 3860663 nudE 7146898 nudE Escherichia coli 55989 ADP-ribose diphosphatase NudE YP_002404744.1 3860103 R 585055 CDS YP_002404745.1 218697078 7147039 3860983..3863118 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11553591; Product type r : regulator; intracellular growth attenuator protein 3863118 igaA 7147039 igaA Escherichia coli 55989 intracellular growth attenuator protein YP_002404745.1 3860983 D 585055 CDS YP_002404746.1 218697079 7146545 3863183..3863851 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase 3863851 yrfG 7146545 yrfG Escherichia coli 55989 hydrolase YP_002404746.1 3863183 D 585055 CDS YP_002404747.1 218697080 7149463 3863862..3864263 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9867837, 10675343, 10675344; Product type f : factor; ribosome-associated heat shock protein Hsp15 3864263 hslR 7149463 hslR Escherichia coli 55989 ribosome-associated heat shock protein Hsp15 YP_002404747.1 3863862 D 585055 CDS YP_002404748.1 218697081 7146469 3864288..3865166 1 NC_011748.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 3865166 hslO 7146469 hslO Escherichia coli 55989 Hsp33-like chaperonin YP_002404748.1 3864288 D 585055 CDS YP_002404749.1 218697082 7146468 complement(3865301..3867025) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20223645; Product type pm : membrane component; inner membrane protein 3867025 yhgE 7146468 yhgE Escherichia coli 55989 inner membrane protein YP_002404749.1 3865301 R 585055 CDS YP_002404750.1 218697083 7148972 complement(3867101..3867232) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 3867232 7148972 EC55989_3808 Escherichia coli 55989 hypothetical protein YP_002404750.1 3867101 R 585055 CDS YP_002404751.1 218697084 7145012 3867404..3869026 1 NC_011748.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 3869026 pck 7145012 pck Escherichia coli 55989 phosphoenolpyruvate carboxykinase YP_002404751.1 3867404 D 585055 CDS YP_002404752.1 218697085 7147120 3869143..3869460 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3869460 7147120 EC55989_3810 Escherichia coli 55989 hypothetical protein YP_002404752.1 3869143 D 585055 CDS YP_002404753.1 218697086 7145013 3869519..3869815 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404279; Product type pr : regulator; HTH-type transcriptional regulator yiaG 3869815 7145013 EC55989_3811 Escherichia coli 55989 HTH-type transcriptional regulator yiaG YP_002404753.1 3869519 D 585055 CDS YP_002404754.1 218697087 7145014 complement(3869845..3871197) 1 NC_011748.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein 3871197 envZ 7145014 envZ Escherichia coli 55989 osmolarity sensor protein YP_002404754.1 3869845 R 585055 CDS YP_002404755.1 218697088 7146008 complement(3871194..3871913) 1 NC_011748.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator 3871913 ompR 7146008 ompR Escherichia coli 55989 osmolarity response regulator YP_002404755.1 3871194 R 585055 CDS YP_002404756.1 218697089 7147070 3872141..3872617 1 NC_011748.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 3872617 greB 7147070 greB Escherichia coli 55989 transcription elongation factor GreB YP_002404756.1 3872141 D 585055 CDS YP_002404757.1 218697090 7146366 3872714..3875035 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 8755871; Product type f : factor; transcriptional accessory protein 3875035 yhgF 7146366 yhgF Escherichia coli 55989 transcriptional accessory protein YP_002404757.1 3872714 D 585055 CDS YP_002404758.1 218697091 7148973 3875473..3875700 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012482, 8407793; Product type t : transporter; ferrous iron transport protein A 3875700 feoA 7148973 feoA Escherichia coli 55989 ferrous iron transport protein A YP_002404758.1 3875473 D 585055 CDS YP_002404759.1 218697092 7146086 3875717..3878038 1 NC_011748.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 3878038 feoB 7146086 feoB Escherichia coli 55989 ferrous iron transport protein B YP_002404759.1 3875717 D 585055 CDS YP_002404760.1 218697093 7146087 3878038..3878274 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 3878274 yhgG 7146087 yhgG Escherichia coli 55989 DNA-binding transcriptional regulator YP_002404760.1 3878038 D 585055 CDS YP_002404761.1 218697094 7148974 3878477..3879355 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2678009; Product type ph : phenotype; hypothetical protein 3879355 yhgA 7148974 yhgA Escherichia coli 55989 hypothetical protein YP_002404761.1 3878477 D 585055 CDS YP_002404762.1 218697095 7148971 complement(3879384..3880154) 1 NC_011748.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH 3880154 bioH 7148971 bioH Escherichia coli 55989 carboxylesterase BioH YP_002404762.1 3879384 R 585055 CDS YP_002404763.1 218697096 7145629 3880192..3880875 1 NC_011748.1 involved in high-affinity gluconate transport; gluconate periplasmic binding protein 3880875 gntX 7145629 gntX Escherichia coli 55989 gluconate periplasmic binding protein YP_002404763.1 3880192 D 585055 CDS YP_002404764.1 218697097 7146354 3880934..3881509 1 NC_011748.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein 3881509 gntY 7146354 gntY Escherichia coli 55989 DNA uptake protein YP_002404764.1 3880934 D 585055 CDS YP_002404765.1 218697098 7146355 3881870..3883186 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 4574689, 4582156, 93139975, 97141270, 98019089, 2845225, 3040894, 7984428, 9045817; Product type t : transporter; gluconate transporter, high-affinity GNT I system 3883186 gntT 7146355 gntT Escherichia coli 55989 gluconate transporter, high-affinity GNT I system YP_002404765.1 3881870 D 585055 CDS YP_002404766.1 218697099 7146352 complement(3883231..3885315) 1 NC_011748.1 amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase 3885315 malQ 7146352 malQ Escherichia coli 55989 4-alpha-glucanotransferase YP_002404766.1 3883231 R 585055 CDS YP_002404767.1 218697100 7146775 complement(3885325..3887718) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033892, 10220320, 10469642, 2845225, 3037809, 3155826, 6283313, 6339728, 6986282, 9009262; Product type e : enzyme; maltodextrin phosphorylase 3887718 malP 7146775 malP Escherichia coli 55989 maltodextrin phosphorylase YP_002404767.1 3885325 R 585055 CDS YP_002404768.1 218697101 7146774 3888330..3891035 1 NC_011748.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 3891035 malT 7146774 malT Escherichia coli 55989 transcriptional regulator MalT YP_002404768.1 3888330 D 585055 CDS YP_002404769.1 218697102 7146777 complement(3891078..3892094) 1 NC_011748.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase 3892094 rtcA 7146777 rtcA Escherichia coli 55989 RNA 3'-terminal-phosphate cyclase YP_002404769.1 3891078 R 585055 CDS YP_002404770.1 218697103 7147552 complement(3892098..3893324) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9738023; hypothetical protein 3893324 rtcB 7147552 rtcB Escherichia coli 55989 hypothetical protein YP_002404770.1 3892098 R 585055 CDS YP_002404771.1 218697104 7147553 3893513..3895111 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9738023, 3045764, 7920643, 7984428; Product type r : regulator; sigma 54-dependent transcriptional regulator of rtcBA expression 3895111 rtcR 7147553 rtcR Escherichia coli 55989 sigma 54-dependent transcriptional regulator of rtcBA expression YP_002404771.1 3893513 D 585055 CDS YP_002404772.1 218697105 7147554 complement(3895093..3895851) 1 NC_011748.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR 3895851 glpR 7147554 glpR Escherichia coli 55989 DNA-binding transcriptional repressor GlpR YP_002404772.1 3895093 R 585055 CDS YP_002404773.1 218697106 7146324 complement(3895868..3896698) 1 NC_011748.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG 3896698 glpG 7146324 glpG Escherichia coli 55989 intramembrane serine protease GlpG YP_002404773.1 3895868 R 585055 CDS YP_002404774.1 218697107 7146321 complement(3896743..3897069) 1 NC_011748.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase 3897069 glpE 7146321 glpE Escherichia coli 55989 thiosulfate sulfurtransferase YP_002404774.1 3896743 R 585055 CDS YP_002404775.1 218697108 7146319 3897259..3898764 1 NC_011748.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 3898764 glpD 7146319 glpD Escherichia coli 55989 glycerol-3-phosphate dehydrogenase YP_002404775.1 3897259 D 585055 CDS YP_002404776.1 218697109 7146318 complement(3898816..3899421) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3899421 7146318 EC55989_3834 Escherichia coli 55989 hypothetical protein YP_002404776.1 3898816 R 585055 CDS YP_002404777.1 218697110 7145015 complement(3899424..3900191) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3900191 7145015 EC55989_3835 Escherichia coli 55989 hypothetical protein YP_002404777.1 3899424 R 585055 CDS YP_002404778.1 218697111 7145016 complement(3900194..3900904) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3900904 7145016 EC55989_3836 Escherichia coli 55989 hypothetical protein YP_002404778.1 3900194 R 585055 CDS YP_002404779.1 218697112 7145017 complement(3900920..3902437) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; membrane protein; ATP binding protein of ABC transporter 3902437 7145017 EC55989_3837 Escherichia coli 55989 membrane protein; ATP binding protein of ABC transporter YP_002404779.1 3900920 R 585055 CDS YP_002404780.1 218697113 7145018 complement(3902553..3905000) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88330897, 91104907, 91236706, 2645169, 2975249, 3047129, 3097003; Product type e : enzyme; glycogen phosphorylase 3905000 glgP 7145018 glgP Escherichia coli 55989 glycogen phosphorylase YP_002404780.1 3902553 R 585055 CDS YP_002404781.1 218697114 7146295 complement(3905019..3906452) 1 NC_011748.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase 3906452 glgA 7146295 glgA Escherichia coli 55989 glycogen synthase YP_002404781.1 3905019 R 585055 CDS YP_002404782.1 218697115 7146292 complement(3906452..3907747) 1 NC_011748.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase 3907747 glgC 7146292 glgC Escherichia coli 55989 glucose-1-phosphate adenylyltransferase YP_002404782.1 3906452 R 585055 CDS YP_002404783.1 218697116 7146294 complement(3907765..3909738) 1 NC_011748.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching protein 3909738 glgX 7146294 glgX Escherichia coli 55989 glycogen debranching protein YP_002404783.1 3907765 R 585055 CDS YP_002404784.1 218697117 7146297 complement(3909735..3911921) 1 NC_011748.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein 3911921 glgB 7146297 glgB Escherichia coli 55989 glycogen branching protein YP_002404784.1 3909735 R 585055 CDS YP_002404785.1 218697118 7146293 complement(3912194..3913297) 1 NC_011748.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase 3913297 asd 7146293 asd Escherichia coli 55989 aspartate-semialdehyde dehydrogenase YP_002404785.1 3912194 R 585055 CDS YP_002404786.1 218697119 7145563 3913490..3914083 1 NC_011748.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); dITP- and XTP- hydrolase 3914083 yhgN 7145563 yhgN Escherichia coli 55989 dITP- and XTP- hydrolase YP_002404786.1 3913490 D 585055 CDS YP_002404787.1 218697120 7148975 complement(3914140..3915480) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8655507, 9119199, 9135111, 97141270; Product type t : transporter; low affinity gluconate transporter 3915480 gntU 7148975 gntU Escherichia coli 55989 low affinity gluconate transporter YP_002404787.1 3914140 R 585055 CDS YP_002404788.1 218697121 7146353 complement(3915484..3916011) 1 NC_011748.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase 3916011 gntK 7146353 gntK Escherichia coli 55989 gluconate kinase YP_002404788.1 3915484 R 585055 CDS YP_002404789.1 218697122 7146349 complement(3916150..3917145) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 9135111, 93139975, 9537375, 8655507; Product type r : regulator; DNA-binding transcriptional repressor 3917145 gntR 7146349 gntR Escherichia coli 55989 DNA-binding transcriptional repressor YP_002404789.1 3916150 R 585055 CDS YP_002404790.1 218697123 7146351 complement(3917369..3918064) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3918064 yhhW 7146351 yhhW Escherichia coli 55989 hypothetical protein YP_002404790.1 3917369 R 585055 CDS YP_002404791.1 218697124 7148991 complement(3918187..3919224) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10493123; Product type pe : enzyme; dehydrogenase 3919224 yhhX 7148991 yhhX Escherichia coli 55989 dehydrogenase YP_002404791.1 3918187 R 585055 CDS YP_002404792.1 218697125 7147592 3919556..3920044 1 NC_011748.1 YhhY; regulated by the fur regulator; unknown function; acetyltransferase YhhY 3920044 yhhY 7147592 yhhY Escherichia coli 55989 acetyltransferase YhhY YP_002404792.1 3919556 D 585055 CDS YP_002404793.1 218697126 7148993 3920281..3921459 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3921459 yhhZ 7148993 yhhZ Escherichia coli 55989 hypothetical protein YP_002404793.1 3920281 D 585055 CDS YP_002404794.1 218697127 7148994 3921456..3921950 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3921950 yrhA 7148994 yrhA Escherichia coli 55989 hypothetical protein YP_002404794.1 3921456 D 585055 CDS YP_002404795.1 218697128 7149464 3922036..3922200 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3922200 yrhD 7149464 yrhD Escherichia coli 55989 hypothetical protein YP_002404795.1 3922036 D 585055 CDS YP_002404796.1 218697129 7149466 3922400..3922684 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3922684 yrhB 7149466 yrhB Escherichia coli 55989 hypothetical protein YP_002404796.1 3922400 D 585055 CDS YP_002404797.1 218697130 7149465 complement(3922722..3924464) 1 NC_011748.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase 3924464 ggt 7149465 ggt Escherichia coli 55989 gamma-glutamyltranspeptidase YP_002404797.1 3922722 R 585055 CDS YP_002404798.1 218697131 7146282 3924584..3925024 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3925024 yhhA 7146282 yhhA Escherichia coli 55989 hypothetical protein YP_002404798.1 3924584 D 585055 CDS YP_002404799.1 218697132 7148976 complement(3925011..3925754) 1 NC_011748.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; glycerophosphodiester phosphodiesterase 3925754 ugpQ 7148976 ugpQ Escherichia coli 55989 glycerophosphodiester phosphodiesterase YP_002404799.1 3925011 R 585055 CDS YP_002404800.1 218697133 7147904 complement(3925751..3926821) 1 NC_011748.1 part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit 3926821 ugpC 7147904 ugpC Escherichia coli 55989 glycerol-3-phosphate transporter ATP-binding subunit YP_002404800.1 3925751 R 585055 CDS YP_002404801.1 218697134 7147902 complement(3926823..3927668) 1 NC_011748.1 with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein 3927668 ugpE 7147902 ugpE Escherichia coli 55989 glycerol-3-phosphate transporter membrane protein YP_002404801.1 3926823 R 585055 CDS YP_002404802.1 218697135 7147903 complement(3927665..3928552) 1 NC_011748.1 with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease 3928552 ugpA 7147903 ugpA Escherichia coli 55989 glycerol-3-phosphate transporter permease YP_002404802.1 3927665 R 585055 CDS YP_002404803.1 218697136 7147900 complement(3928650..3929966) 1 NC_011748.1 with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein 3929966 ugpB 7147900 ugpB Escherichia coli 55989 glycerol-3-phosphate transporter periplasmic binding protein YP_002404803.1 3928650 R 585055 CDS YP_002404804.1 218697137 7147901 complement(3930362..3931075) 1 NC_011748.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 3931075 livF 7147901 livF Escherichia coli 55989 leucine/isoleucine/valine transporter ATP-binding subunit YP_002404804.1 3930362 R 585055 CDS YP_002404805.1 218697138 7146705 complement(3931077..3931844) 1 NC_011748.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit 3931844 livG 7146705 livG Escherichia coli 55989 leucine/isoleucine/valine transporter ATP-binding subunit YP_002404805.1 3931077 R 585055 CDS YP_002404806.1 218697139 7146706 complement(3931841..3933118) 1 NC_011748.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit 3933118 livM 7146706 livM Escherichia coli 55989 leucine/isoleucine/valine transporter permease subunit YP_002404806.1 3931841 R 585055 CDS YP_002404807.1 218697140 7146710 complement(3933115..3934041) 1 NC_011748.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease subunit LivH 3934041 livH 7146710 livH Escherichia coli 55989 branched-chain amino acid transporter permease subunit LivH YP_002404807.1 3933115 R 585055 CDS YP_002404808.1 218697141 7146707 complement(3934089..3935198) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649683, 3891753, 4077929, 9298646, 9298646; Product type t : transporter; leucine ABC transporter subunit substrate-binding protein 3935198 livK 7146707 livK Escherichia coli 55989 leucine ABC transporter subunit substrate-binding protein YP_002404808.1 3934089 R 585055 CDS YP_002404809.1 218697142 7146709 3935622..3936005 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3936005 yhhK 7146709 yhhK Escherichia coli 55989 hypothetical protein YP_002404809.1 3935622 D 585055 CDS YP_002404810.1 218697143 7148985 complement(3936204..3937307) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649682, 328304, 3891753, 4077929, 9298646, 10972807; Product type t : transporter; leucine/isoleucine/valine transporter subunit ; periplasmic-binding component of ABC superfamily 3937307 livJ 7148985 livJ Escherichia coli 55989 leucine/isoleucine/valine transporter subunit ; periplasmic-binding component of ABC superfamily YP_002404810.1 3936204 R 585055 CDS YP_002404811.1 218697144 7146708 complement(3937578..3938432) 1 NC_011748.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 3938432 rpoH 7146708 rpoH Escherichia coli 55989 RNA polymerase factor sigma-32 YP_002404811.1 3937578 R 585055 CDS YP_002404812.1 218697145 7147500 complement(3938677..3939735) 1 NC_011748.1 ABC transporter, membrane protein; cell division protein FtsX 3939735 ftsX 7147500 ftsX Escherichia coli 55989 cell division protein FtsX YP_002404812.1 3938677 R 585055 CDS YP_002404813.1 218697146 7146220 complement(3939728..3940396) 1 NC_011748.1 ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE 3940396 ftsE 7146220 ftsE Escherichia coli 55989 cell division protein FtsE YP_002404813.1 3939728 R 585055 CDS YP_002404814.1 218697147 7146212 complement(3940399..3941892) 1 NC_011748.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY 3941892 ftsY 7146212 ftsY Escherichia coli 55989 cell division protein FtsY YP_002404814.1 3940399 R 585055 CDS YP_002404815.1 218697148 7146221 3942042..3942638 1 NC_011748.1 catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 3942638 rsmD 7146221 rsmD Escherichia coli 55989 16S rRNA m(2)G966-methyltransferase YP_002404815.1 3942042 D 585055 CDS YP_002404816.1 218697149 7148977 3942505..3942897 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3942897 7148977 EC55989_3874 Escherichia coli 55989 hypothetical protein YP_002404816.1 3942505 D 585055 CDS YP_002404817.1 218697150 7145019 complement(3942900..3943259) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3943259 yhhM 7145019 yhhM Escherichia coli 55989 hypothetical protein YP_002404817.1 3942900 R 585055 CDS YP_002404818.1 218697151 7148986 3943400..3944026 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3944026 yhhN 7148986 yhhN Escherichia coli 55989 inner membrane protein YP_002404818.1 3943400 D 585055 CDS YP_002404819.1 218697152 7148987 3944100..3946298 1 NC_011748.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 3946298 zntA 7148987 zntA Escherichia coli 55989 zinc/cadmium/mercury/lead-transporting ATPase YP_002404819.1 3944100 D 585055 CDS YP_002404820.1 218697153 7149490 complement(3946400..3946645) 1 NC_011748.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA 3946645 tusA 7149490 tusA Escherichia coli 55989 sulfur transfer protein SirA YP_002404820.1 3946400 R 585055 CDS YP_002404821.1 218697154 7147875 3946866..3947531 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 3947531 yhhQ 7147875 yhhQ Escherichia coli 55989 hypothetical protein YP_002404821.1 3946866 D 585055 CDS YP_002404822.1 218697155 7148988 3947604..3948161 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12558182, 8752353; Product type t : transporter; hypothetical protein 3948161 dcrB 7148988 dcrB Escherichia coli 55989 hypothetical protein YP_002404822.1 3947604 D 585055 CDS YP_002404823.1 218697156 7145858 complement(3948165..3949382) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; major facilitator superfamily transporter 3949382 yhhS 7145858 yhhS Escherichia coli 55989 major facilitator superfamily transporter YP_002404823.1 3948165 R 585055 CDS YP_002404824.1 218697157 7148989 3949514..3950563 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3950563 yhhT 7148989 yhhT Escherichia coli 55989 inner membrane protein YP_002404824.1 3949514 D 585055 CDS YP_002404825.1 218697158 7148990 3950618..3951205 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20092861, 10625633, 8939709; Product type e : enzyme; holo-(acyl carrier protein) synthase 2 3951205 acpT 7148990 acpT Escherichia coli 55989 holo-(acyl carrier protein) synthase 2 YP_002404825.1 3950618 D 585055 CDS YP_002404826.1 218697159 7145443 3951316..3952890 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12960164, 7934931, 92077434, 7867647; Product type t : transporter; nickel transporter subunit ; periplasmic-binding component of ABC superfamily 3952890 nikA 7145443 nikA Escherichia coli 55989 nickel transporter subunit ; periplasmic-binding component of ABC superfamily YP_002404826.1 3951316 D 585055 CDS YP_002404827.1 218697160 7146995 3952890..3953834 1 NC_011748.1 with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 3953834 nikB 7146995 nikB Escherichia coli 55989 nickel transporter permease NikB YP_002404827.1 3952890 D 585055 CDS YP_002404828.1 218697161 7146996 3953831..3954664 1 NC_011748.1 with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 3954664 nikC 7146996 nikC Escherichia coli 55989 nickel transporter permease NikC YP_002404828.1 3953831 D 585055 CDS YP_002404829.1 218697162 7146997 3954664..3955428 1 NC_011748.1 with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 3955428 nikD 7146997 nikD Escherichia coli 55989 nickel transporter ATP-binding protein NikD YP_002404829.1 3954664 D 585055 CDS YP_002404830.1 218697163 7146998 3955425..3956231 1 NC_011748.1 with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 3956231 nikE 7146998 nikE Escherichia coli 55989 nickel transporter ATP-binding protein NikE YP_002404830.1 3955425 D 585055 CDS YP_002404831.1 218697164 7146999 3956237..3956638 1 NC_011748.1 Inhibits transcription at high concentrations of nickel; nickel responsive regulator 3956638 nikR 7146999 nikR Escherichia coli 55989 nickel responsive regulator YP_002404831.1 3956237 D 585055 CDS YP_002404832.1 218697165 7147000 complement(3956758..3957117) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3957117 7147000 EC55989_3890 Escherichia coli 55989 hypothetical protein YP_002404832.1 3956758 R 585055 CDS YP_002404833.1 218697166 7145020 complement(3957448..3958572) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: membrane component of ABC superfamily 3958572 yhhJ 7145020 yhhJ Escherichia coli 55989 transporter subunit: membrane component of ABC superfamily YP_002404833.1 3957448 R 585055 CDS YP_002404834.1 218697167 7148984 complement(3958572..3961307) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20074572; Product type e : enzyme; fused ribosome-associated ATPase: ATP-binding protein ; ATP-binding protein ; membrane protein 3961307 rbbA 7148984 rbbA Escherichia coli 55989 fused ribosome-associated ATPase: ATP-binding protein ; ATP-binding protein ; membrane protein YP_002404834.1 3958572 R 585055 CDS YP_002404835.1 218697168 7147338 complement(3961304..3962371) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; HlyD family secretion protein 3962371 yhiI 7147338 yhiI Escherichia coli 55989 HlyD family secretion protein YP_002404835.1 3961304 R 585055 CDS YP_002404836.1 218697169 7145023 3966629..3967681 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3967681 yhiM 7145023 yhiM Escherichia coli 55989 inner membrane protein YP_002404836.1 3966629 D 585055 CDS YP_002404837.1 218697170 7149000 complement(3968341..3968808) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8594334, 16940062, 15518875; Product type h : extrachromosomal origin; hypothetical protein 3968808 7149000 EC55989_3900 Escherichia coli 55989 hypothetical protein YP_002404837.1 3968341 R 585055 CDS YP_002404838.1 218697171 7145024 complement(3968993..3970393) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; sensor protein pcoS 3970393 7145024 EC55989_3901 Escherichia coli 55989 sensor protein pcoS YP_002404838.1 3968993 R 585055 CDS YP_002404839.1 218697172 7145025 complement(3970390..3971076) 1 NC_011748.1 Transcriptional regulatory protein pcoR 3971076 7145025 EC55989_3902 Escherichia coli 55989 Transcriptional regulatory protein pcoR YP_002404839.1 3970390 R 585055 CDS YP_002404840.1 218697173 7145026 complement(3971125..3972054) 1 NC_011748.1 Copper resistance protein D 3972054 7145026 EC55989_3903 Escherichia coli 55989 Copper resistance protein D YP_002404840.1 3971125 R 585055 CDS YP_002404841.1 218697174 7145027 complement(3972059..3972439) 1 NC_011748.1 Copper resistance protein C precursor 3972439 7145027 EC55989_3904 Escherichia coli 55989 Copper resistance protein C precursor YP_002404841.1 3972059 R 585055 CDS YP_002404842.1 218697175 7145028 complement(3972479..3973378) 1 NC_011748.1 Copper resistance protein B precursor 3973378 7145028 EC55989_3905 Escherichia coli 55989 Copper resistance protein B precursor YP_002404842.1 3972479 R 585055 CDS YP_002404843.1 218697176 7145029 complement(3973375..3975198) 1 NC_011748.1 Copper resistance protein A precursor 3975198 7145029 EC55989_3906 Escherichia coli 55989 Copper resistance protein A precursor YP_002404843.1 3973375 R 585055 CDS YP_002404844.1 218697177 7145030 3975427..3975876 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8594334, 15518875, 15276215, 16940062; hypothetical protein 3975876 7145030 EC55989_3907 Escherichia coli 55989 hypothetical protein YP_002404844.1 3975427 D 585055 CDS YP_002404845.1 218697178 7145031 3976165..3976902 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15518875, 15276215, 16940062; Product type pe : enzyme; peptidase 3976902 7145031 EC55989_3908 Escherichia coli 55989 peptidase YP_002404845.1 3976165 D 585055 CDS YP_002404846.1 218697179 7145032 complement(3977174..3979621) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9930866, 15518875, 15276215, 16940062; Product type pt : transporter; cation-transporting P-type ATPase 3979621 silP 7145032 silP Escherichia coli 55989 cation-transporting P-type ATPase YP_002404846.1 3977174 R 585055 CDS YP_002404847.1 218697180 7147658 complement(3979748..3980194) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9930866, 15518875, 15276215, 16940062; hypothetical protein 3980194 7147658 EC55989_3911 Escherichia coli 55989 hypothetical protein YP_002404847.1 3979748 R 585055 CDS YP_002404848.1 218697181 7145033 complement(3980275..3983421) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 21125583, 21178899, 21450803, 11399769, 12813074, 1711024, 7984428; Product type t : transporter; copper/silver efflux system, membrane component 3983421 cusA 7145033 cusA Escherichia coli 55989 copper/silver efflux system, membrane component YP_002404848.1 3980275 R 585055 CDS YP_002404849.1 218697182 7145791 complement(3983432..3984724) 1 NC_011748.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 3984724 silB 7145791 silB Escherichia coli 55989 copper/silver efflux system membrane fusion protein CusB YP_002404849.1 3983432 R 585055 CDS YP_002404850.1 218697183 7147655 complement(3984838..3985191) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9930866, 15518875, 16940062; copper-binding protein 3985191 7147655 EC55989_3914 Escherichia coli 55989 copper-binding protein YP_002404850.1 3984838 R 585055 CDS YP_002404851.1 218697184 7145034 complement(3985219..3986907) 1 NC_011748.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 3986907 silC 7145034 silC Escherichia coli 55989 copper/silver efflux system outer membrane protein CusC YP_002404851.1 3985219 R 585055 CDS YP_002404852.1 218697185 7147656 3986794..3987474 1 NC_011748.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR 3987474 cusR 7147656 cusR Escherichia coli 55989 DNA-binding transcriptional activator CusR YP_002404852.1 3986794 D 585055 CDS YP_002404853.1 218697186 7145796 3987467..3988948 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type pr : regulator; sensor kinase CusS 3988948 7145796 EC55989_3918 Escherichia coli 55989 sensor kinase CusS YP_002404853.1 3987467 D 585055 CDS YP_002404854.1 218697187 7145035 3989076..3989624 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 9930866; Product type f : factor; silver-binding protein SilE 3989624 silE 7145035 silE Escherichia coli 55989 silver-binding protein SilE YP_002404854.1 3989076 D 585055 CDS YP_002404855.1 218697188 7147657 3989772..3990122 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15518875, 16940062; hypothetical protein 3990122 7147657 EC55989_3920 Escherichia coli 55989 hypothetical protein YP_002404855.1 3989772 D 585055 CDS YP_002404856.1 218697189 7145036 complement(3990291..3992177) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15518875, 16940062; hypothetical protein 3992177 7145036 EC55989_3921 Escherichia coli 55989 hypothetical protein YP_002404856.1 3990291 R 585055 CDS YP_002404857.1 218697190 7145037 complement(3992681..3993010) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15518875, 16940062; Product type pr : regulator; transcriptional regulator 3993010 7145037 EC55989_3922 Escherichia coli 55989 transcriptional regulator YP_002404857.1 3992681 R 585055 CDS YP_002404858.1 218697191 7145038 complement(3993333..3994259) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15518875, 16940062; hypothetical protein 3994259 7145038 EC55989_3923 Escherichia coli 55989 hypothetical protein YP_002404858.1 3993333 R 585055 CDS YP_002404859.1 218697192 7145039 3995125..3995400 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1849492; Product type r : regulator; Insertion element IS1 protein InsA 3995400 7145039 EC55989_3924 Escherichia coli 55989 Insertion element IS1 protein InsA YP_002404859.1 3995125 D 585055 CDS YP_002404860.1 218697193 7145040 3995319..3995822 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 273224, 375010, 1849492; Product type pe : enzyme; Insertion element IS1 1/5/6 protein InsB 3995822 7145040 EC55989_3925 Escherichia coli 55989 Insertion element IS1 1/5/6 protein InsB YP_002404860.1 3995319 D 585055 CDS YP_002404861.1 218697194 7145041 complement(3995816..3996613) 1 NC_011748.1 Evidence 7 : Gene remnant; PubMedId : 2156235, 1655576, 8947057; hypothetical protein, Tn7-like transposition protein TnsD (fragment) 3996613 7145041 EC55989_3926 Escherichia coli 55989 hypothetical protein, Tn7-like transposition protein TnsD (fragment) YP_002404861.1 3995816 R 585055 CDS YP_002404862.1 218697195 7145042 complement(3996645..3998093) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2156235, 1655576, 8947057; Product type pe : enzyme; Tn7-like transposition protein TnsC 3998093 7145042 EC55989_3927 Escherichia coli 55989 Tn7-like transposition protein TnsC YP_002404862.1 3996645 R 585055 CDS YP_002404863.1 218697196 7145043 complement(3998093..4000216) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2156235, 1655576, 8947057, 10704304, 1657979; Product type pe : enzyme; Tn7-like transposition protein TnsB 4000216 7145043 EC55989_3928 Escherichia coli 55989 Tn7-like transposition protein TnsB YP_002404863.1 3998093 R 585055 CDS YP_002404864.1 218697197 7145044 complement(4000203..4001045) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 2156235, 1655576, 8947057, 10704304; Product type pe : enzyme; Tn7-like transposase TnsA 4001045 7145044 EC55989_3929 Escherichia coli 55989 Tn7-like transposase TnsA YP_002404864.1 4000203 R 585055 CDS YP_002404865.1 218697198 7145045 complement(4001188..4002390) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase with FAD/NAD(P)-binding domain 4002390 yhiN 7145045 yhiN Escherichia coli 55989 oxidoreductase with FAD/NAD(P)-binding domain YP_002404865.1 4001188 R 585055 CDS YP_002404866.1 218697199 7149001 4002622..4004121 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87014120; Product type t : transporter; phosphate transporter, low-affinity 4004121 pitA 7149001 pitA Escherichia coli 55989 phosphate transporter, low-affinity YP_002404866.1 4002622 D 585055 CDS YP_002404867.1 218697200 7147191 complement(4004192..4004527) 1 NC_011748.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB 4004527 yhiO 7147191 yhiO Escherichia coli 55989 universal stress protein UspB YP_002404867.1 4004192 R 585055 CDS YP_002404868.1 218697201 7149002 4004918..4005352 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 93086426, 93308072, 94203056, 10499297, 10652104, 10931298, 11157932, 1453957, 8506346, 8932299, 9298646, 9405142; Product type f : factor; universal stress global response regulator 4005352 uspA 7149002 uspA Escherichia coli 55989 universal stress global response regulator YP_002404868.1 4004918 D 585055 CDS YP_002404869.1 218697202 7147928 4005670..4007139 1 NC_011748.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 4007139 yhiP 7147928 yhiP Escherichia coli 55989 inner membrane transporter YhiP YP_002404869.1 4005670 D 585055 CDS YP_002404870.1 218697203 7149003 complement(4007188..4007940) 1 NC_011748.1 predicted SAM-dependent methyltransferase; methyltransferase 4007940 yhiQ 7149003 yhiQ Escherichia coli 55989 methyltransferase YP_002404870.1 4007188 R 585055 CDS YP_002404871.1 218697204 7149004 complement(4007948..4009990) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92394891, 1325967, 8366062; Product type e : enzyme; oligopeptidase A 4009990 prlC 7149004 prlC Escherichia coli 55989 oligopeptidase A YP_002404871.1 4007948 R 585055 CDS YP_002404872.1 218697205 7147248 4010193..4011035 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11591672; Product type pe : enzyme; DNA (exogenous) processing protein 4011035 yhiR 7147248 yhiR Escherichia coli 55989 DNA (exogenous) processing protein YP_002404872.1 4010193 D 585055 CDS YP_002404873.1 218697206 7149005 4011107..4012459 1 NC_011748.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 4012459 gor 7149005 gor Escherichia coli 55989 glutathione reductase YP_002404873.1 4011107 D 585055 CDS YP_002404874.1 218697207 7146356 complement(4012513..4012662) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 4012662 7146356 EC55989_3939 Escherichia coli 55989 hypothetical protein YP_002404874.1 4012513 R 585055 CDS YP_002404875.1 218697208 7145046 4012618..4012797 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 4012797 7145046 EC55989_3940 Escherichia coli 55989 hypothetical protein YP_002404875.1 4012618 D 585055 CDS YP_002404876.1 218697209 7145047 4013336..4013689 1 NC_011748.1 regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 4013689 arsR 7145047 arsR Escherichia coli 55989 DNA-binding transcriptional repressor ArsR YP_002404876.1 4013336 D 585055 CDS YP_002404877.1 218697210 7145554 4013743..4015032 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15004242, 95355341, 1535622, 7721697; Product type t : transporter; arsenite/antimonite transporter 4015032 arsB 7145554 arsB Escherichia coli 55989 arsenite/antimonite transporter YP_002404877.1 4013743 D 585055 CDS YP_002404878.1 218697211 7145552 4015045..4015470 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95355341, 7721697; Product type e : enzyme; arsenate reductase 4015470 arsC 7145552 arsC Escherichia coli 55989 arsenate reductase YP_002404878.1 4015045 D 585055 CDS YP_002404879.1 218697212 7145553 complement(4015604..4015900) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4015900 7145553 EC55989_3945 Escherichia coli 55989 hypothetical protein YP_002404879.1 4015604 R 585055 CDS YP_002404880.1 218697213 7145048 4015995..4017020 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; hypothetical protein 4017020 7145048 EC55989_3946 Escherichia coli 55989 hypothetical protein YP_002404880.1 4015995 D 585055 CDS YP_002404881.1 218697214 7145049 4017600..4018745 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4018745 7145049 EC55989_3947 Escherichia coli 55989 hypothetical protein YP_002404881.1 4017600 D 585055 CDS YP_002404882.1 218697215 7145050 4019069..4019635 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293775, 8022277; Product type lp : lipoprotein; outer membrane lipoprotein 4019635 slp 7145050 slp Escherichia coli 55989 outer membrane lipoprotein YP_002404882.1 4019069 D 585055 CDS YP_002404883.1 218697216 7147660 4019791..4020321 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8022277; Product type pr : regulator; DNA-binding transcriptional regulator 4020321 yhiF 7147660 yhiF Escherichia coli 55989 DNA-binding transcriptional regulator YP_002404883.1 4019791 D 585055 CDS YP_002404884.1 218697217 7148996 complement(4020363..4021010) 1 NC_011748.1 inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; Mg(2+) transport ATPase 4021010 yhiD 7148996 yhiD Escherichia coli 55989 Mg(2+) transport ATPase YP_002404884.1 4020363 R 585055 CDS YP_002404885.1 218697218 7148995 complement(4021074..4021400) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8885264, 12071744, 8244952, 8455549, 9298646, 9868784; Product type pf : factor; acid-resistance protein 4021400 hdeB 7148995 hdeB Escherichia coli 55989 acid-resistance protein YP_002404885.1 4021074 R 585055 CDS YP_002404886.1 218697219 7146402 complement(4021516..4021848) 1 NC_011748.1 inactive form; acid-resistance protein 4021848 hdeA 7146402 hdeA Escherichia coli 55989 acid-resistance protein YP_002404886.1 4021516 R 585055 CDS YP_002404887.1 218697220 7146401 4022103..4022675 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8244952, 8455549; Product type pm : membrane component; acid-resistance membrane protein 4022675 hdeD 7146401 hdeD Escherichia coli 55989 acid-resistance membrane protein YP_002404887.1 4022103 D 585055 CDS YP_002404888.1 218697221 7146403 4023474..4024001 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12399493, 12940989, 14702398; Product type r : regulator; DNA-binding transcriptional activator 4024001 gadE 7146403 gadE Escherichia coli 55989 DNA-binding transcriptional activator YP_002404888.1 4023474 D 585055 CDS YP_002404889.1 218697222 7146243 4024340..4025497 1 NC_011748.1 with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 4025497 mdtE 7146243 mdtE Escherichia coli 55989 multidrug efflux system protein MdtE YP_002404889.1 4024340 D 585055 CDS YP_002404890.1 218697223 7146806 4025522..4028635 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803; Product type t : transporter; multidrug transporter, RpoS-dependent 4028635 mdtF 7146806 mdtF Escherichia coli 55989 multidrug transporter, RpoS-dependent YP_002404890.1 4025522 D 585055 CDS YP_002404891.1 218697224 7146807 complement(4028998..4029726) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12446650; Product type r : regulator; DNA-binding transcriptional activator 4029726 gadW 7146807 gadW Escherichia coli 55989 DNA-binding transcriptional activator YP_002404891.1 4028998 R 585055 CDS YP_002404892.1 218697225 7146246 complement(4030094..4030918) 1 NC_011748.1 regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX 4030918 gadX 7146246 gadX Escherichia coli 55989 DNA-binding transcriptional regulator GadX YP_002404892.1 4030094 R 585055 CDS YP_002404893.1 218697226 7146245 complement(4031288..4032688) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92155241, 92394884, 99406302, 1522060, 1740158, 7764225, 9298646; Product type e : enzyme; glutamate decarboxylase 4032688 gadA 7146245 gadA Escherichia coli 55989 glutamate decarboxylase YP_002404893.1 4031288 R 585055 CDS YP_002404894.1 218697227 7146240 complement(4032899..4034296) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8163487, 14563563; Product type e : enzyme; cytochrome C peroxidase (cpp-like) 4034296 yhjA 7146240 yhjA Escherichia coli 55989 cytochrome C peroxidase (cpp-like) YP_002404894.1 4032899 R 585055 CDS YP_002404895.1 218697228 7149006 4034701..4036350 1 NC_011748.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 4036350 treF 7149006 treF Escherichia coli 55989 trehalase YP_002404895.1 4034701 D 585055 CDS YP_002404896.1 218697229 7147838 complement(4036401..4037003) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding response regulator in two-component regulatory system 4037003 yhjB 7147838 yhjB Escherichia coli 55989 DNA-binding response regulator in two-component regulatory system YP_002404896.1 4036401 R 585055 CDS YP_002404897.1 218697230 7149007 4037451..4038422 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 4038422 yhjC 7149007 yhjC Escherichia coli 55989 DNA-binding transcriptional regulator YP_002404897.1 4037451 D 585055 CDS YP_002404898.1 218697231 7149008 4038471..4039484 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4039484 yhjD 7149008 yhjD Escherichia coli 55989 inner membrane protein YP_002404898.1 4038471 D 585055 CDS YP_002404899.1 218697232 7149009 4039895..4041217 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4041217 yhjE 7149009 yhjE Escherichia coli 55989 transporter YP_002404899.1 4039895 D 585055 CDS YP_002404900.1 218697233 7149010 complement(4041451..4043526) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; outer membrane biogenesis protein 4043526 yhjG 7149010 yhjG Escherichia coli 55989 outer membrane biogenesis protein YP_002404900.1 4041451 R 585055 CDS YP_002404901.1 218697234 7149011 complement(4043581..4044348) 1 NC_011748.1 in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein 4044348 yhjH 7149011 yhjH Escherichia coli 55989 EAL domain-containing protein YP_002404901.1 4043581 R 585055 CDS YP_002404902.1 218697235 7149012 4044302..4044496 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 4044496 7149012 EC55989_3972 Escherichia coli 55989 hypothetical protein YP_002404902.1 4044302 D 585055 CDS YP_002404903.1 218697236 7145051 4044580..4045509 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4359651, 13813474; Product type e : enzyme; ketodeoxygluconokinase 4045509 kdgK 7145051 kdgK Escherichia coli 55989 ketodeoxygluconokinase YP_002404903.1 4044580 D 585055 CDS YP_002404904.1 218697237 7146651 complement(4045605..4047101) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pe : enzyme; zinc-dependent peptidase 4047101 yhjJ 7146651 yhjJ Escherichia coli 55989 zinc-dependent peptidase YP_002404904.1 4045605 R 585055 CDS YP_002404905.1 218697238 7149013 complement(4047322..4048608) 1 NC_011748.1 involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA 4048608 dctA 7149013 dctA Escherichia coli 55989 C4-dicarboxylate transporter DctA YP_002404905.1 4047322 R 585055 CDS YP_002404906.1 218697239 7145859 complement(4048791..4050740) 1 NC_011748.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase protein from E. coli; phosphodiesterase 4050740 yhjK 7145859 yhjK Escherichia coli 55989 phosphodiesterase YP_002404906.1 4048791 R 585055 CDS YP_002404907.1 218697240 7149014 complement(4050861..4054334) 1 NC_011748.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; cellulose synthase subunit BcsC 4054334 bcsC 7149014 bcsC Escherichia coli 55989 cellulose synthase subunit BcsC YP_002404907.1 4050861 R 585055 CDS YP_002404908.1 218697241 7145604 complement(4054316..4055422) 1 NC_011748.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase 4055422 bcsZ 7145604 bcsZ Escherichia coli 55989 endo-1,4-D-glucanase YP_002404908.1 4054316 R 585055 CDS YP_002404909.1 218697242 7145608 complement(4055429..4057768) 1 NC_011748.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein 4057768 bcsB 7145608 bcsB Escherichia coli 55989 cellulose synthase regulator protein YP_002404909.1 4055429 R 585055 CDS YP_002404910.1 218697243 7145603 complement(4057779..4060397) 1 NC_011748.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit 4060397 bcsA 7145603 bcsA Escherichia coli 55989 cellulose synthase catalytic subunit YP_002404910.1 4057779 R 585055 CDS YP_002404911.1 218697244 7145602 complement(4060394..4061146) 1 NC_011748.1 cell division protein 4061146 7145602 EC55989_3981 Escherichia coli 55989 cell division protein YP_002404911.1 4060394 R 585055 CDS YP_002404912.1 218697245 7145052 complement(4061158..4061346) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4061346 yhjR 7145052 yhjR Escherichia coli 55989 hypothetical protein YP_002404912.1 4061158 R 585055 CDS YP_002404913.1 218697246 7149015 4061619..4063190 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : enzyme; cellulose biosynthesis protease 4063190 bcsE 7149015 bcsE Escherichia coli 55989 cellulose biosynthesis protease YP_002404913.1 4061619 D 585055 CDS YP_002404914.1 218697247 7145605 4063187..4063378 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4063378 bcsF 7145605 bcsF Escherichia coli 55989 hypothetical protein YP_002404914.1 4063187 D 585055 CDS YP_002404915.1 218697248 7145606 4063375..4065054 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : enzyme; cellulose biosynthesis endoglucanase 4065054 bcsG 7145606 bcsG Escherichia coli 55989 cellulose biosynthesis endoglucanase YP_002404915.1 4063375 D 585055 CDS YP_002404916.1 218697249 7147356 complement(4066107..4066349) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123448; Product type f : factor; toxic polypeptide, small 4066349 ldrD 7147356 ldrD Escherichia coli 55989 toxic polypeptide, small YP_002404916.1 4066107 R 585055 CDS YP_002404917.1 218697250 7147355 complement(4066861..4067022) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4067022 7147355 EC55989_3989 Escherichia coli 55989 hypothetical protein YP_002404917.1 4066861 R 585055 CDS YP_002404918.1 218697251 7145053 4067172..4068443 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 15901718; Product type t : transporter; transporter 4068443 yhjV 7145053 yhjV Escherichia coli 55989 transporter YP_002404918.1 4067172 D 585055 CDS YP_002404919.1 218697252 7149016 complement(4068473..4069477) 1 NC_011748.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit 4069477 dppF 7149016 dppF Escherichia coli 55989 dipeptide transporter ATP-binding subunit YP_002404919.1 4068473 R 585055 CDS YP_002404920.1 218697253 7145948 complement(4069474..4070457) 1 NC_011748.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit 4070457 dppD 7145948 dppD Escherichia coli 55989 dipeptide transporter ATP-binding subunit YP_002404920.1 4069474 R 585055 CDS YP_002404921.1 218697254 7145947 complement(4070468..4071370) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7536291; Product type t : transporter; dipeptide transporter 4071370 dppC 7145947 dppC Escherichia coli 55989 dipeptide transporter YP_002404921.1 4070468 R 585055 CDS YP_002404922.1 218697255 7145946 complement(4071380..4072399) 1 NC_011748.1 transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB 4072399 dppB 7145946 dppB Escherichia coli 55989 dipeptide transporter permease DppB YP_002404922.1 4071380 R 585055 CDS YP_002404923.1 218697256 7145945 4072417..4072560 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4072560 7145945 EC55989_3995 Escherichia coli 55989 hypothetical protein YP_002404923.1 4072417 D 585055 CDS YP_002404924.1 218697257 7145054 complement(4072550..4074157) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100289, 92065799, 1702779, 1956284, 7536291, 8527431, 8563629, 9298646, 9600841, 9740056, 10972807; Product type t : transporter; dipeptide transporter ; periplasmic-binding component of ABC superfamily 4074157 dppA 7145054 dppA Escherichia coli 55989 dipeptide transporter ; periplasmic-binding component of ABC superfamily YP_002404924.1 4072550 R 585055 CDS YP_002404925.1 218697258 7145373 complement(4075069..4076760) 1 NC_011748.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase 4076760 eptB 7145373 eptB Escherichia coli 55989 phosphoethanolamine transferase YP_002404925.1 4075069 R 585055 CDS YP_002404926.1 218697259 7146019 complement(4077013..4077537) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type pm : membrane component; LpfE protein precursor 4077537 lpfE 7146019 lpfE Escherichia coli 55989 LpfE protein precursor YP_002404926.1 4077013 R 585055 CDS YP_002404927.1 218697260 7146730 complement(4077543..4078598) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; LpfD protein precursor 4078598 lpfD 7146730 lpfD Escherichia coli 55989 LpfD protein precursor YP_002404927.1 4077543 R 585055 CDS YP_002404928.1 218697261 7146728 complement(4078609..4081140) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; Outer membrane usher protein lpfC precursor 4081140 lpfC 7146728 lpfC Escherichia coli 55989 Outer membrane usher protein lpfC precursor YP_002404928.1 4078609 R 585055 CDS YP_002404929.1 218697262 7146726 complement(4081164..4081850) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; Chaperone protein lpfB precursor 4081850 lpfB 7146726 lpfB Escherichia coli 55989 Chaperone protein lpfB precursor YP_002404929.1 4081164 R 585055 CDS YP_002404930.1 218697263 7146725 complement(4081934..4082458) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; Long polar fimbria protein A precursor 4082458 lpfA 7146725 lpfA Escherichia coli 55989 Long polar fimbria protein A precursor YP_002404930.1 4081934 R 585055 CDS YP_002404931.1 218697264 7146723 complement(4082782..4084029) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4084029 yhjX 7146723 yhjX Escherichia coli 55989 transporter YP_002404931.1 4082782 R 585055 CDS YP_002404932.1 218697265 7149017 complement(4084213..4084911) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4084911 yhjY 7149017 yhjY Escherichia coli 55989 hypothetical protein YP_002404932.1 4084213 R 585055 CDS YP_002404933.1 218697266 7149018 4085069..4085632 1 NC_011748.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyladenine DNA glycosylase 4085632 tag 7149018 tag Escherichia coli 55989 3-methyladenine DNA glycosylase YP_002404933.1 4085069 D 585055 CDS YP_002404934.1 218697267 7147746 4085629..4086069 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11237876; Product type pe : enzyme; hypothetical protein 4086069 yiaC 7147746 yiaC Escherichia coli 55989 hypothetical protein YP_002404934.1 4085629 D 585055 CDS YP_002404935.1 218697268 7149021 complement(4086038..4088317) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82119950, 90202748, 2180922, 374979; Product type e : enzyme; biotin sulfoxide reductase 4088317 bisC 7149021 bisC Escherichia coli 55989 biotin sulfoxide reductase YP_002404935.1 4086038 R 585055 CDS YP_002404936.1 218697269 7145632 4088524..4089183 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; outer membrane lipoprotein 4089183 yiaD 7145632 yiaD Escherichia coli 55989 outer membrane lipoprotein YP_002404936.1 4088524 D 585055 CDS YP_002404937.1 218697270 7149022 4089287..4090261 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15801772, 11237876, 99030322, 99357626, 9298646, 9811658; Product type e : enzyme; 2-oxo-carboxylic acid reductase (glyoxalate reductase) (2-ketoaldonate reductase) 4090261 tiaE 7149022 tiaE Escherichia coli 55989 2-oxo-carboxylic acid reductase (glyoxalate reductase) (2-ketoaldonate reductase) YP_002404937.1 4089287 D 585055 CDS YP_002404938.1 218697271 7147800 complement(4090311..4091021) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4091021 yiaF 7147800 yiaF Escherichia coli 55989 hypothetical protein YP_002404938.1 4090311 R 585055 CDS YP_002404939.1 218697272 7149023 4091455..4091745 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 4091745 yiaG 7149023 yiaG Escherichia coli 55989 transcriptional regulator YP_002404939.1 4091455 D 585055 CDS YP_002404940.1 218697273 7149024 4092026..4092238 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 90115858, 94293754, 94293756, 99177178, 10696873, 1597410, 1961761, 2404279, 7515185, 8197194, 9405743, 9439003, 9692981; Product type f : factor; major cold shock protein 4092238 cspA 7149024 cspA Escherichia coli 55989 major cold shock protein YP_002404940.1 4092026 D 585055 CDS YP_002404941.1 218697274 7145777 complement(4092904..4094973) 1 NC_011748.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta 4094973 glyS 7145777 glyS Escherichia coli 55989 glycyl-tRNA synthetase subunit beta YP_002404941.1 4092904 R 585055 CDS YP_002404942.1 218697275 7146341 complement(4094983..4095894) 1 NC_011748.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha 4095894 glyQ 7146341 glyQ Escherichia coli 55989 glycyl-tRNA synthetase subunit alpha YP_002404942.1 4094983 R 585055 CDS YP_002404943.1 218697276 7146340 complement(4095989..4096288) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4096288 ysaB 7146340 ysaB Escherichia coli 55989 hypothetical protein YP_002404943.1 4095989 R 585055 CDS YP_002404944.1 218697277 7149467 4096463..4097458 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4097458 yiaH 7149467 yiaH Escherichia coli 55989 inner membrane protein YP_002404944.1 4096463 D 585055 CDS YP_002404945.1 218697278 7149025 complement(4097500..4097937) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 4097937 yiaA 7149025 yiaA Escherichia coli 55989 hypothetical protein YP_002404945.1 4097500 R 585055 CDS YP_002404946.1 218697279 7149019 complement(4097983..4098324) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6320721; Product type pm : membrane component; hypothetical protein 4098324 yiaB 7149019 yiaB Escherichia coli 55989 hypothetical protein YP_002404946.1 4097983 R 585055 CDS YP_002404947.1 218697280 7149020 complement(4098493..4099947) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 92366447, 95050816, 6320721; Product type e : enzyme; xylulokinase 4099947 xylB 7149020 xylB Escherichia coli 55989 xylulokinase YP_002404947.1 4098493 R 585055 CDS YP_002404948.1 218697281 7147996 complement(4100019..4101341) 1 NC_011748.1 catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase 4101341 xylA 7147996 xylA Escherichia coli 55989 xylose isomerase YP_002404948.1 4100019 R 585055 CDS YP_002404949.1 218697282 7147995 4101707..4102699 1 NC_011748.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 4102699 xylF 7147995 xylF Escherichia coli 55989 D-xylose transporter subunit XylF YP_002404949.1 4101707 D 585055 CDS YP_002404950.1 218697283 7147998 4102777..4104318 1 NC_011748.1 with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 4104318 xylG 7147998 xylG Escherichia coli 55989 xylose transporter ATP-binding subunit YP_002404950.1 4102777 D 585055 CDS YP_002404951.1 218697284 7147999 4104296..4105477 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500; Product type t : transporter; D-xylose transporter subunit ; membrane component of ABC superfamily 4105477 xylH 7147999 xylH Escherichia coli 55989 D-xylose transporter subunit ; membrane component of ABC superfamily YP_002404951.1 4104296 D 585055 CDS YP_002404952.1 218697285 7148000 4105389..4105565 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 4105565 7148000 EC55989_4024 Escherichia coli 55989 hypothetical protein YP_002404952.1 4105389 D 585055 CDS YP_002404953.1 218697286 7145055 4105555..4106733 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 94316500; Product type r : regulator; DNA-binding transcriptional activator, xylose-binding 4106733 xylR 7145055 xylR Escherichia coli 55989 DNA-binding transcriptional activator, xylose-binding YP_002404953.1 4105555 D 585055 CDS YP_002404954.1 218697287 7148001 complement(4106929..4107753) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1544897; hypothetical protein 4107753 bax 7148001 bax Escherichia coli 55989 hypothetical protein YP_002404954.1 4106929 R 585055 CDS YP_002404955.1 218697288 7145599 4108073..4110103 1 NC_011748.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase 4110103 malS 7145599 malS Escherichia coli 55989 periplasmic alpha-amylase YP_002404955.1 4108073 D 585055 CDS YP_002404956.1 218697289 7146776 4110281..4111534 1 NC_011748.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 4111534 avtA 7146776 avtA Escherichia coli 55989 valine--pyruvate transaminase YP_002404956.1 4110281 D 585055 CDS YP_002404957.1 218697290 7145589 complement(4111686..4112159) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; hydrogenase, 4Fe-4S ferredoxin-type component 4112159 yiaI 7145589 yiaI Escherichia coli 55989 hydrogenase, 4Fe-4S ferredoxin-type component YP_002404957.1 4111686 R 585055 CDS YP_002404958.1 218697291 7149026 complement(4112261..4113109) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 20372646, 9826648; Product type r : regulator; DNA-binding transcriptional repressor 4113109 yiaJ 7149026 yiaJ Escherichia coli 55989 DNA-binding transcriptional repressor YP_002404958.1 4112261 R 585055 CDS YP_002404959.1 218697292 7149027 4113310..4114308 1 NC_011748.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 4114308 yiaK 7149027 yiaK Escherichia coli 55989 2,3-diketo-L-gulonate reductase YP_002404959.1 4113310 D 585055 CDS YP_002404960.1 218697293 7149028 4114320..4114787 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21617392; hypothetical protein 4114787 yiaL 7149028 yiaL Escherichia coli 55989 hypothetical protein YP_002404960.1 4114320 D 585055 CDS YP_002404961.1 218697294 7149029 4114905..4115378 1 NC_011748.1 membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO; 2,3-diketo-L-gulonate TRAP transporter small permease 4115378 yiaM 7149029 yiaM Escherichia coli 55989 2,3-diketo-L-gulonate TRAP transporter small permease YP_002404961.1 4114905 D 585055 CDS YP_002404962.1 218697295 7149030 4115381..4116658 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 4116658 yiaN 7149030 yiaN Escherichia coli 55989 transporter YP_002404962.1 4115381 D 585055 CDS YP_002404963.1 218697296 7149031 4116671..4117657 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 4117657 yiaO 7149031 yiaO Escherichia coli 55989 transporter YP_002404963.1 4116671 D 585055 CDS YP_002404964.1 218697297 7149032 4117661..4119157 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21617392, 95050816, 7961955; Product type e : enzyme; L-xylulose kinase 4119157 lyxK 7149032 lyxK Escherichia coli 55989 L-xylulose kinase YP_002404964.1 4117661 D 585055 CDS YP_002404965.1 218697298 7146761 4119154..4119816 1 NC_011748.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate; 3-keto-L-gulonate-6-phosphate decarboxylase 4119816 sgbH 7146761 sgbH Escherichia coli 55989 3-keto-L-gulonate-6-phosphate decarboxylase YP_002404965.1 4119154 D 585055 CDS YP_002404966.1 218697299 7147648 4119809..4120669 1 NC_011748.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase 4120669 sgbU 7147648 sgbU Escherichia coli 55989 L-xylulose 5-phosphate 3-epimerase YP_002404966.1 4119809 D 585055 CDS YP_002404967.1 218697300 7147649 4120663..4121358 1 NC_011748.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4121358 sgbE 7147649 sgbE Escherichia coli 55989 L-ribulose-5-phosphate 4-epimerase YP_002404967.1 4120663 D 585055 CDS YP_002404968.1 218697301 7147647 complement(4121705..4122445) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; outer membrane protein 4122445 yiaT 7147647 yiaT Escherichia coli 55989 outer membrane protein YP_002404968.1 4121705 R 585055 CDS YP_002404969.1 218697302 7149033 4122569..4123543 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 4123543 yiaU 7149033 yiaU Escherichia coli 55989 DNA-binding transcriptional regulator YP_002404969.1 4122569 D 585055 CDS YP_002404970.1 218697303 7149034 complement(4123540..4124676) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15668009; Product type t : transporter; membrane fusion protein (MFP) component of efflux pump, signal anchor 4124676 yiaV 7149034 yiaV Escherichia coli 55989 membrane fusion protein (MFP) component of efflux pump, signal anchor YP_002404970.1 4123540 R 585055 CDS YP_002404971.1 218697304 7149035 complement(4124682..4125005) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4125005 yiaW 7149035 yiaW Escherichia coli 55989 inner membrane protein YP_002404971.1 4124682 R 585055 CDS YP_002404972.1 218697305 7149036 4125119..4125331 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; membrane protein 4125331 7149036 EC55989_4045 Escherichia coli 55989 membrane protein YP_002404972.1 4125119 D 585055 CDS YP_002404973.1 218697306 7145056 complement(4125550..4127088) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95286498, 7768815; Product type e : enzyme; aldehyde dehydrogenase 4127088 aldB 7145056 aldB Escherichia coli 55989 aldehyde dehydrogenase YP_002404973.1 4125550 R 585055 CDS YP_002404974.1 218697307 7145480 complement(4127253..4128404) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2935393; Product type e : enzyme; alcohol dehydrogenase 4128404 yiaY 7145480 yiaY Escherichia coli 55989 alcohol dehydrogenase YP_002404974.1 4127253 R 585055 CDS YP_002404975.1 218697308 7149037 complement(4128594..4130438) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264431, 91317715, 9315303, 94148228, 2140572, 2531290; Product type f : factor; selenocysteinyl-tRNA-specific translation factor 4130438 selB 7149037 selB Escherichia coli 55989 selenocysteinyl-tRNA-specific translation factor YP_002404975.1 4128594 R 585055 CDS YP_002404976.1 218697309 7147629 complement(4130435..4131826) 1 NC_011748.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase 4131826 selA 7147629 selA Escherichia coli 55989 selenocysteine synthase YP_002404976.1 4130435 R 585055 CDS YP_002404977.1 218697310 7147628 complement(4131924..4132532) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8387990; Product type pe : enzyme; glutathione S-transferase 4132532 yibF 7147628 yibF Escherichia coli 55989 glutathione S-transferase YP_002404977.1 4131924 R 585055 CDS YP_002404978.1 218697311 7149041 4132531..4132674 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4132674 7149041 EC55989_4051 Escherichia coli 55989 hypothetical protein YP_002404978.1 4132531 D 585055 CDS YP_002404979.1 218697312 7145057 4132761..4136726 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 2403547, 2644231, 7934896, 8387990; Product type h : extrachromosomal origin; rhsB element core protein RshB 4136726 rhsB 7145057 rhsB Escherichia coli 55989 rhsB element core protein RshB YP_002404979.1 4132761 D 585055 CDS YP_002404980.1 218697313 7147400 4136968..4137351 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4137351 yhhH 7147400 yhhH Escherichia coli 55989 hypothetical protein YP_002404980.1 4136968 D 585055 CDS YP_002404981.1 218697314 7149038 complement(4137970..4138473) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 273224, 375010, 1849492; Product type pe : enzyme; Insertion element IS1 1/5/6 protein InsB 4138473 7149038 EC55989_4055 Escherichia coli 55989 Insertion element IS1 1/5/6 protein InsB YP_002404981.1 4137970 R 585055 CDS YP_002404982.1 218697315 7145058 complement(4138392..4138667) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1849492; Product type r : regulator; Insertion element IS1 protein InsA 4138667 7145058 EC55989_4056 Escherichia coli 55989 Insertion element IS1 protein InsA YP_002404982.1 4138392 R 585055 CDS YP_002404983.1 218697316 7149039 4139117..4140061 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; rhs protein (modular protein) 4140061 7149039 EC55989_4058 Escherichia coli 55989 rhs protein (modular protein) YP_002404983.1 4139117 D 585055 CDS YP_002404984.1 218697317 7145060 4140073..4140534 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4140534 yibG 7145060 yibG Escherichia coli 55989 hypothetical protein YP_002404984.1 4140073 D 585055 CDS YP_002404985.1 218697318 7145061 complement(4142133..4143269) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4143269 yibH 7145061 yibH Escherichia coli 55989 hypothetical protein YP_002404985.1 4142133 R 585055 CDS YP_002404986.1 218697319 7149043 complement(4143272..4143634) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4143634 yibI 7149043 yibI Escherichia coli 55989 inner membrane protein YP_002404986.1 4143272 R 585055 CDS YP_002404987.1 218697320 7149044 4144171..4146084 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052139, 92283796, 94131964, 1946374, 3135464, 3142516, 6309813, 9551558; Product type t : transporter; fused mannitol-specific PTS enzymes: IIA components ; IIB components ; IIC components 4146084 mtlA 7149044 mtlA Escherichia coli 55989 fused mannitol-specific PTS enzymes: IIA components ; IIB components ; IIC components YP_002404987.1 4144171 D 585055 CDS YP_002404988.1 218697321 7146914 4146314..4147462 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90254197, 1964486, 3135464, 6384188, 8300537, 13295236; Product type e : enzyme; mannitol-1-phosphate 5-dehydrogenase 4147462 mtlD 7146914 mtlD Escherichia coli 55989 mannitol-1-phosphate 5-dehydrogenase YP_002404988.1 4146314 D 585055 CDS YP_002404989.1 218697322 7146915 4147462..4148049 1 NC_011748.1 Acts as a repressor of the mtlAD operon; mannitol repressor protein 4148049 mtlR 7146915 mtlR Escherichia coli 55989 mannitol repressor protein YP_002404989.1 4147462 D 585055 CDS YP_002404990.1 218697323 7146916 complement(4148061..4148270) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4148270 yibT 7146916 yibT Escherichia coli 55989 hypothetical protein YP_002404990.1 4148061 R 585055 CDS YP_002404991.1 218697324 7149049 4148555..4148917 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4148917 yibL 7149049 yibL Escherichia coli 55989 hypothetical protein YP_002404991.1 4148555 D 585055 CDS YP_002404992.1 218697325 7149046 4149461..4150144 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4150144 7149046 EC55989_4068 Escherichia coli 55989 hypothetical protein YP_002404992.1 4149461 D 585055 CDS YP_002404993.1 218697326 7145062 4150188..4155038 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; adhesin 4155038 7145062 EC55989_4069 Escherichia coli 55989 adhesin YP_002404993.1 4150188 D 585055 CDS YP_002404994.1 218697327 7145063 4155407..4157062 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012541, 11283302, 11785976, 8407843; Product type t : transporter; L-lactate permease 4157062 lldP 7145063 lldP Escherichia coli 55989 L-lactate permease YP_002404994.1 4155407 D 585055 CDS YP_002404995.1 218697328 7146712 4157062..4157838 1 NC_011748.1 represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4157838 lldR 7146712 lldR Escherichia coli 55989 DNA-binding transcriptional repressor LldR YP_002404995.1 4157062 D 585055 CDS YP_002404996.1 218697329 7146713 4157835..4159025 1 NC_011748.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4159025 lldD 7146713 lldD Escherichia coli 55989 L-lactate dehydrogenase YP_002404996.1 4157835 D 585055 CDS YP_002404997.1 218697330 7146711 4159211..4159684 1 NC_011748.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; tRNA/rRNA methyltransferase YibK 4159684 yibK 7146711 yibK Escherichia coli 55989 tRNA/rRNA methyltransferase YibK YP_002404997.1 4159211 D 585055 CDS YP_002404998.1 218697331 7149045 complement(4159737..4160558) 1 NC_011748.1 catalyzes the O-acetylation of serine; serine acetyltransferase 4160558 cysE 7149045 cysE Escherichia coli 55989 serine acetyltransferase YP_002404998.1 4159737 R 585055 CDS YP_002404999.1 218697332 7145824 complement(4160638..4161657) 1 NC_011748.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase 4161657 gpsA 7145824 gpsA Escherichia coli 55989 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase YP_002404999.1 4160638 R 585055 CDS YP_002405000.1 218697333 7146363 complement(4161657..4162124) 1 NC_011748.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be to SecA; preprotein translocase subunit SecB 4162124 secB 7146363 secB Escherichia coli 55989 preprotein translocase subunit SecB YP_002405000.1 4161657 R 585055 CDS YP_002405001.1 218697334 7147621 complement(4162187..4162438) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500, 95024051, 99175138, 11031118, 7937896, 8636094, 9973569; Product type c : carrier; glutaredoxin 3 4162438 grxC 7147621 grxC Escherichia coli 55989 glutaredoxin 3 YP_002405001.1 4162187 R 585055 CDS YP_002405002.1 218697335 7146372 complement(4162580..4163011) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; rhodanese-related sulfurtransferase 4163011 yibN 7146372 yibN Escherichia coli 55989 rhodanese-related sulfurtransferase YP_002405002.1 4162580 R 585055 CDS YP_002405003.1 218697336 7149047 4163256..4164800 1 NC_011748.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4164800 gpmI 7149047 gpmI Escherichia coli 55989 phosphoglyceromutase YP_002405003.1 4163256 D 585055 CDS YP_002405004.1 218697337 7146361 4164834..4166093 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12113939, 21972773; Product type cp : cell process; hypothetical protein 4166093 envC 7146361 envC Escherichia coli 55989 hypothetical protein YP_002405004.1 4164834 D 585055 CDS YP_002405005.1 218697338 7146005 4166097..4167056 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; polysaccharide deacetylase 4167056 yibQ 7146005 yibQ Escherichia coli 55989 polysaccharide deacetylase YP_002405005.1 4166097 D 585055 CDS YP_002405006.1 218697339 7149048 complement(4167043..4168077) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15659689, 2647748; Product type pe : enzyme; glycosyl transferase family protein 4168077 yibD 7149048 yibD Escherichia coli 55989 glycosyl transferase family protein YP_002405006.1 4167043 R 585055 CDS YP_002405007.1 218697340 7149040 complement(4168316..4169341) 1 NC_011748.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase 4169341 tdh 7149040 tdh Escherichia coli 55989 L-threonine 3-dehydrogenase YP_002405007.1 4168316 R 585055 CDS YP_002405008.1 218697341 7147771 complement(4169351..4170547) 1 NC_011748.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate CoA ligase 4170547 kbl 7147771 kbl Escherichia coli 55989 2-amino-3-ketobutyrate CoA ligase YP_002405008.1 4169351 R 585055 CDS YP_002405009.1 218697342 7146649 complement(4170822..4171679) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4171679 htrL 7146649 htrL Escherichia coli 55989 hypothetical protein YP_002405009.1 4170822 R 585055 CDS YP_002405010.1 218697343 7146479 4171983..4172915 1 NC_011748.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase 4172915 rfaD 7146479 rfaD Escherichia coli 55989 ADP-L-glycero-D-manno-heptose-6-epimerase YP_002405010.1 4171983 D 585055 CDS YP_002405011.1 218697344 7147957 4172925..4173971 1 NC_011748.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose--LPS heptosyltransferase 4173971 waaF 7147957 waaF Escherichia coli 55989 ADP-heptose--LPS heptosyltransferase YP_002405011.1 4172925 D 585055 CDS YP_002405012.1 218697345 7147958 4173975..4174967 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20507564, 92250420, 93239678, 9446588, 1624462, 8478319; Product type e : enzyme; ADP-heptose--LPS heptosyltransferase 4174967 waaC 7147958 waaC Escherichia coli 55989 ADP-heptose--LPS heptosyltransferase YP_002405012.1 4173975 D 585055 CDS YP_002405013.1 218697346 7147956 4174964..4176172 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1657881; Product type e : enzyme; O-antigen ligase 4176172 rfaL 7147956 rfaL Escherichia coli 55989 O-antigen ligase YP_002405013.1 4174964 D 585055 CDS YP_002405014.1 218697347 7147379 complement(4176208..4177350) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Lipopolysaccharide 1, 2-N-acetylglucosaminetransferase 4177350 rfaK 7147379 rfaK Escherichia coli 55989 Lipopolysaccharide 1, 2-N-acetylglucosaminetransferase YP_002405014.1 4176208 R 585055 CDS YP_002405015.1 218697348 7147378 complement(4177359..4178372) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92210496, 92250420, 92325066, 99251135, 1624461; Product type e : enzyme; Lipopolysaccharide 1,2-glucosyltransferase 4178372 rfaJ 7147378 rfaJ Escherichia coli 55989 Lipopolysaccharide 1,2-glucosyltransferase YP_002405015.1 4177359 R 585055 CDS YP_002405016.1 218697349 7147377 complement(4178397..4179104) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1624462, 8041620, 9278503, 92250420, 92325067, 9756860; Product type e : enzyme; lipopolysaccharide core biosynthesis protein 4179104 rfaY 7147377 rfaY Escherichia coli 55989 lipopolysaccharide core biosynthesis protein YP_002405016.1 4178397 R 585055 CDS YP_002405017.1 218697350 7147380 complement(4179130..4180137) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92210496, 92250420, 92325066, 9765561, 1624461; Product type e : enzyme; Lipopolysaccharide 1,3-galactosyltransferase 4180137 rfaI 7147380 rfaI Escherichia coli 55989 Lipopolysaccharide 1,3-galactosyltransferase YP_002405017.1 4179130 R 585055 CDS YP_002405018.1 218697351 7147376 complement(4180180..4180986) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101922, 92121133, 92210496, 9756860, 1732225; Product type e : enzyme; kinase that phosphorylates core heptose of lipopolysaccharide 4180986 waaP 7147376 waaP Escherichia coli 55989 kinase that phosphorylates core heptose of lipopolysaccharide YP_002405018.1 4180180 R 585055 CDS YP_002405019.1 218697352 7147960 complement(4180970..4182094) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92121133, 92210496, 92250420, 1447141, 1732225, 7988890; Product type e : enzyme; glucosyltransferase I 4182094 waaG 7147960 waaG Escherichia coli 55989 glucosyltransferase I YP_002405019.1 4180970 R 585055 CDS YP_002405020.1 218697353 7147959 complement(4182091..4183149) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9756860, 1447141, 1732225; Product type e : enzyme; lipopolysaccharide core biosynthesis protein 4183149 waaQ 7147959 waaQ Escherichia coli 55989 lipopolysaccharide core biosynthesis protein YP_002405020.1 4182091 R 585055 CDS YP_002405021.1 218697354 7147961 4183562..4184839 1 NC_011748.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 4184839 kdtA 7147961 kdtA Escherichia coli 55989 3-deoxy-D-manno-octulosonic-acid transferase YP_002405021.1 4183562 D 585055 CDS YP_002405022.1 218697355 7146663 4184847..4185326 1 NC_011748.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 4185326 coaD 7146663 coaD Escherichia coli 55989 phosphopantetheine adenylyltransferase YP_002405022.1 4184847 D 585055 CDS YP_002405023.1 218697356 7145733 complement(4185365..4186174) 1 NC_011748.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase 4186174 mutM 7145733 mutM Escherichia coli 55989 formamidopyrimidine-DNA glycosylase YP_002405023.1 4185365 R 585055 CDS YP_002405024.1 218697357 7146933 complement(4186272..4186439) 1 NC_011748.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 4186439 rpmG 7146933 rpmG Escherichia coli 55989 50S ribosomal protein L33 YP_002405024.1 4186272 R 585055 CDS YP_002405025.1 218697358 7147492 complement(4186460..4186696) 1 NC_011748.1 required for 70S ribosome assembly; 50S ribosomal protein L28 4186696 rpmB 7147492 rpmB Escherichia coli 55989 50S ribosomal protein L28 YP_002405025.1 4186460 R 585055 CDS YP_002405026.1 218697359 7147487 complement(4186913..4187581) 1 NC_011748.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC 4187581 radC 7147487 radC Escherichia coli 55989 DNA repair protein RadC YP_002405026.1 4186913 R 585055 CDS YP_002405027.1 218697360 7149060 4187753..4188973 1 NC_011748.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 4188973 dfp 7149060 dfp Escherichia coli 55989 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase YP_002405027.1 4187753 D 585055 CDS YP_002405028.1 218697361 7145893 4188954..4189409 1 NC_011748.1 catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 4189409 dut 7145893 dut Escherichia coli 55989 deoxyuridine 5'-triphosphate nucleotidohydrolase YP_002405028.1 4188954 D 585055 CDS YP_002405029.1 218697362 7145962 4189516..4190112 1 NC_011748.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 4190112 slmA 7145962 slmA Escherichia coli 55989 nucleoid occlusion protein YP_002405029.1 4189516 D 585055 CDS YP_002405030.1 218697363 7147871 complement(4190149..4190790) 1 NC_011748.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase 4190790 pyrE 7147871 pyrE Escherichia coli 55989 orotate phosphoribosyltransferase YP_002405030.1 4190149 R 585055 CDS YP_002405031.1 218697364 7147320 complement(4190856..4191596) 1 NC_011748.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH 4191596 rph 7147320 rph Escherichia coli 55989 ribonuclease PH YP_002405031.1 4190856 R 585055 CDS YP_002405032.1 218697365 7147461 4191699..4192562 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4192562 yicC 7147461 yicC Escherichia coli 55989 hypothetical protein YP_002405032.1 4191699 D 585055 CDS YP_002405033.1 218697366 7149050 4192771..4193607 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 913680, 94334998, 95095962, 1925027, 2158980, 2664418, 8002613, 8057377, 8195095; Product type cp : cell process; DNA-damage-inducible protein D 4193607 dinD 7149050 dinD Escherichia coli 55989 DNA-damage-inducible protein D YP_002405033.1 4192771 D 585055 CDS YP_002405034.1 218697367 7145915 4193899..4194516 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4194516 yicG 7145915 yicG Escherichia coli 55989 inner membrane protein YP_002405034.1 4193899 D 585055 CDS YP_002405035.1 218697368 7149052 complement(4194513..4196195) 1 NC_011748.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB 4196195 ligB 7149052 ligB Escherichia coli 55989 NAD-dependent DNA ligase LigB YP_002405035.1 4194513 R 585055 CDS YP_002405036.1 218697369 7146701 4196453..4197076 1 NC_011748.1 Essential for recycling GMP and indirectly, cGMP; guanylate kinase 4197076 gmk 7146701 gmk Escherichia coli 55989 guanylate kinase YP_002405036.1 4196453 D 585055 CDS YP_002405037.1 218697370 7146344 4197131..4197406 1 NC_011748.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 4197406 rpoZ 7146344 rpoZ Escherichia coli 55989 DNA-directed RNA polymerase subunit omega YP_002405037.1 4197131 D 585055 CDS YP_002405038.1 218697371 7147503 4197425..4199533 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12224635, 89255395, 93266525, 94068533, 2005134, 2549050; Product type e : enzyme; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 4199533 spoT 7147503 spoT Escherichia coli 55989 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase YP_002405038.1 4197425 D 585055 CDS YP_002405039.1 218697372 7147693 4199540..4200229 1 NC_011748.1 specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 4200229 trmH 7147693 trmH Escherichia coli 55989 tRNA guanosine-2'-O-methyltransferase YP_002405039.1 4199540 D 585055 CDS YP_002405040.1 218697373 7147848 4200235..4202316 1 NC_011748.1 catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 4202316 recG 7147848 recG Escherichia coli 55989 ATP-dependent DNA helicase RecG YP_002405040.1 4200235 D 585055 CDS YP_002405041.1 218697374 7147362 complement(4202482..4203687) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91203811, 93106943, 1544582, 2017136, 2254324; Product type t : transporter; glutamate transporter 4203687 gltS 7147362 gltS Escherichia coli 55989 glutamate transporter YP_002405041.1 4202482 R 585055 CDS YP_002405042.1 218697375 7146335 4203967..4205358 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4205358 yicE 7146335 yicE Escherichia coli 55989 transporter YP_002405042.1 4203967 D 585055 CDS YP_002405043.1 218697376 7149051 4205479..4207188 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4207188 yicH 7149051 yicH Escherichia coli 55989 hypothetical protein YP_002405043.1 4205479 D 585055 CDS YP_002405044.1 218697377 7149053 complement(4207241..4209559) 1 NC_011748.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase 4209559 yicI 7149053 yicI Escherichia coli 55989 alpha-xylosidase YP_002405044.1 4207241 R 585055 CDS YP_002405045.1 218697378 7149054 complement(4209569..4210951) 1 NC_011748.1 may be involved in the transport of galactosides-pentoses-hexuronides; transporter 4210951 yicJ 7149054 yicJ Escherichia coli 55989 transporter YP_002405045.1 4209569 R 585055 CDS YP_002405046.1 218697379 7145346 4211444..4211593 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4211593 7145346 EC55989_4125 Escherichia coli 55989 hypothetical protein YP_002405046.1 4211444 D 585055 CDS YP_002405047.1 218697380 7145064 4211975..4213159 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10438463, 10209755; Product type pt : transporter; sugar efflux system 4213159 setC 7145064 setC Escherichia coli 55989 sugar efflux system YP_002405047.1 4211975 D 585055 CDS YP_002405048.1 218697381 7147638 4213270..4214193 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4214193 yicL 7147638 yicL Escherichia coli 55989 inner membrane protein YP_002405048.1 4213270 D 585055 CDS YP_002405049.1 218697382 7149056 complement(4214197..4215015) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88298691, 89359178, 9914480, 3003106; Product type lp : lipoprotein; hypothetical protein 4215015 nlpA 7149056 nlpA Escherichia coli 55989 hypothetical protein YP_002405049.1 4214197 R 585055 CDS YP_002405050.1 218697383 7147006 4215237..4215530 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4215530 yicS 7147006 yicS Escherichia coli 55989 hypothetical protein YP_002405050.1 4215237 D 585055 CDS YP_002405051.1 218697384 7149061 complement(4215571..4216926) 1 NC_011748.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter 4216926 nepI 7149061 nepI Escherichia coli 55989 ribonucleoside transporter YP_002405051.1 4215571 R 585055 CDS YP_002405052.1 218697385 7149057 complement(4216972..4217424) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4217424 yicN 7149057 yicN Escherichia coli 55989 hypothetical protein YP_002405052.1 4216972 R 585055 CDS YP_002405053.1 218697386 7149058 complement(4217477..4218811) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; xanthine/uracil permease 4218811 yicO 7149058 yicO Escherichia coli 55989 xanthine/uracil permease YP_002405053.1 4217477 R 585055 CDS YP_002405054.1 218697387 7149059 4218986..4220752 1 NC_011748.1 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 4220752 ade 7149059 ade Escherichia coli 55989 cryptic adenine deaminase YP_002405054.1 4218986 D 585055 CDS YP_002405055.1 218697388 7145454 complement(4220797..4222188) 1 NC_011748.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter 4222188 uhpT 7145454 uhpT Escherichia coli 55989 sugar phosphate antiporter YP_002405055.1 4220797 R 585055 CDS YP_002405056.1 218697389 7147908 complement(4222326..4223645) 1 NC_011748.1 membrane protein regulates uhpT expression; regulatory protein UhpC 4223645 uhpC 7147908 uhpC Escherichia coli 55989 regulatory protein UhpC YP_002405056.1 4222326 R 585055 CDS YP_002405057.1 218697390 7147907 complement(4223655..4225157) 1 NC_011748.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB 4225157 uhpB 7147907 uhpB Escherichia coli 55989 sensory histidine kinase UhpB YP_002405057.1 4223655 R 585055 CDS YP_002405058.1 218697391 7147906 complement(4225157..4225747) 1 NC_011748.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA 4225747 uhpA 7147906 uhpA Escherichia coli 55989 DNA-binding transcriptional activator UhpA YP_002405058.1 4225157 R 585055 CDS YP_002405059.1 218697392 7147905 complement(4225822..4226112) 1 NC_011748.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit 4226112 ilvN 7147905 ilvN Escherichia coli 55989 acetolactate synthase 1 regulatory subunit YP_002405059.1 4225822 R 585055 CDS YP_002405060.1 218697393 7146559 complement(4226116..4227804) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2989782, 85242083, 92380929, 2989781; Product type e : enzyme; acetolactate synthase catalytic subunit 4227804 ilvB 7146559 ilvB Escherichia coli 55989 acetolactate synthase catalytic subunit YP_002405060.1 4226116 R 585055 CDS YP_002405062.1 218697395 7145065 complement(4227910..4228008) 1 NC_011748.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; ilvB operon leader peptide 4228008 ivbL 7145065 ivbL Escherichia coli 55989 ilvB operon leader peptide YP_002405062.1 4227910 R 585055 CDS YP_002405063.1 218697396 7146636 complement(4228537..4228788) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 4228788 7146636 EC55989_4141 Escherichia coli 55989 hypothetical protein YP_002405063.1 4228537 R 585055 CDS YP_002405064.1 218697397 7145066 4229081..4230265 1 NC_011748.1 multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 4230265 emrD 7145066 emrD Escherichia coli 55989 multidrug resistance protein D YP_002405064.1 4229081 D 585055 CDS YP_002405065.1 218697398 7145991 complement(4230273..4230770) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 4230770 yidF 7145991 yidF Escherichia coli 55989 DNA-binding transcriptional regulator YP_002405065.1 4230273 R 585055 CDS YP_002405066.1 218697399 7149067 complement(4230767..4231129) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4231129 yidG 7149067 yidG Escherichia coli 55989 inner membrane protein YP_002405066.1 4230767 R 585055 CDS YP_002405067.1 218697400 7149068 complement(4231119..4231466) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4231466 yidH 7149068 yidH Escherichia coli 55989 inner membrane protein YP_002405067.1 4231119 R 585055 CDS YP_002405068.1 218697401 7149069 4231575..4232024 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4232024 yidI 7149069 yidI Escherichia coli 55989 inner membrane protein YP_002405068.1 4231575 D 585055 CDS YP_002405069.1 218697402 7149070 complement(4232071..4233564) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; sulfatase/phosphatase 4233564 yidJ 7149070 yidJ Escherichia coli 55989 sulfatase/phosphatase YP_002405069.1 4232071 R 585055 CDS YP_002405070.1 218697403 7149071 complement(4233561..4235276) 1 NC_011748.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; symporter YidK 4235276 yidK 7149071 yidK Escherichia coli 55989 symporter YidK YP_002405070.1 4233561 R 585055 CDS YP_002405071.1 218697404 7149072 4235413..4236336 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 4236336 yidL 7149072 yidL Escherichia coli 55989 DNA-binding transcriptional regulator YP_002405071.1 4235413 D 585055 CDS YP_002405072.1 218697405 7145068 complement(4237147..4239024) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; PTS system alpha-glucoside-specific EIICB component 4239024 7145068 EC55989_4152 Escherichia coli 55989 PTS system alpha-glucoside-specific EIICB component YP_002405072.1 4237147 R 585055 CDS YP_002405073.1 218697406 7145069 4239059..4239775 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 4239775 yidP 7145069 yidP Escherichia coli 55989 DNA-binding transcriptional regulator YP_002405073.1 4239059 D 585055 CDS YP_002405074.1 218697407 7149074 complement(4239772..4241433) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1356969; Product type pt : transporter; hypothetical protein 4241433 yidE 7149074 yidE Escherichia coli 55989 hypothetical protein YP_002405074.1 4239772 R 585055 CDS YP_002405075.1 218697408 7149066 complement(4241630..4242058) 1 NC_011748.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB 4242058 ibpB 7149066 ibpB Escherichia coli 55989 heat shock chaperone IbpB YP_002405075.1 4241630 R 585055 CDS YP_002405076.1 218697409 7146532 complement(4242170..4242583) 1 NC_011748.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA 4242583 ibpA 7146532 ibpA Escherichia coli 55989 heat shock protein IbpA YP_002405076.1 4242170 R 585055 CDS YP_002405077.1 218697410 7146531 4242889..4243221 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 4243221 yidQ 7146531 yidQ Escherichia coli 55989 hypothetical protein YP_002405077.1 4242889 D 585055 CDS YP_002405078.1 218697411 7149075 complement(4243223..4244437) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4244437 yidR 7149075 yidR Escherichia coli 55989 hypothetical protein YP_002405078.1 4243223 R 585055 CDS YP_002405079.1 218697412 7149076 4244538..4245602 1 NC_011748.1 FAD/NAD(P)-binding domain; oxidoreductase 4245602 cbrA 7149076 cbrA Escherichia coli 55989 oxidoreductase YP_002405079.1 4244538 D 585055 CDS YP_002405080.1 218697413 7145669 complement(4245599..4246891) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type t : transporter; D-galactonate transporter 4246891 dgoT 7145669 dgoT Escherichia coli 55989 D-galactonate transporter YP_002405080.1 4245599 R 585055 CDS YP_002405081.1 218697414 7145899 complement(4247011..4248159) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; galactonate dehydratase 4248159 dgoD 7145899 dgoD Escherichia coli 55989 galactonate dehydratase YP_002405081.1 4247011 R 585055 CDS YP_002405082.1 218697415 7145896 complement(4248156..4248773) 1 NC_011748.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase 4248773 dgoA 7145896 dgoA Escherichia coli 55989 2-dehydro-3-deoxy-6-phosphogalactonate aldolase YP_002405082.1 4248156 R 585055 CDS YP_002405083.1 218697416 7145895 complement(4248757..4249635) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; 2-oxo-3-deoxygalactonate kinase 4249635 dgoK 7145895 dgoK Escherichia coli 55989 2-oxo-3-deoxygalactonate kinase YP_002405083.1 4248757 R 585055 CDS YP_002405084.1 218697417 7145897 complement(4249632..4250321) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 79020349; Product type pr : regulator; DNA-binding transcriptional regulator 4250321 dgoR 7145897 dgoR Escherichia coli 55989 DNA-binding transcriptional regulator YP_002405084.1 4249632 R 585055 CDS YP_002405085.1 218697418 7145898 4250599..4251255 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 4251255 yidX 7145898 yidX Escherichia coli 55989 hypothetical protein YP_002405085.1 4250599 D 585055 CDS YP_002405086.1 218697419 7149077 complement(4251301..4252113) 1 NC_011748.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase 4252113 yidA 7149077 yidA Escherichia coli 55989 sugar phosphatase YP_002405086.1 4251301 R 585055 CDS YP_002405087.1 218697420 7149062 complement(4252228..4252626) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4252626 yidB 7149062 yidB Escherichia coli 55989 hypothetical protein YP_002405087.1 4252228 R 585055 CDS YP_002405088.1 218697421 7149063 complement(4252866..4255280) 1 NC_011748.1 negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B 4255280 gyrB 7149063 gyrB Escherichia coli 55989 DNA gyrase subunit B YP_002405088.1 4252866 R 585055 CDS YP_002405089.1 218697422 7146389 complement(4255309..4256382) 1 NC_011748.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F 4256382 recF 7146389 recF Escherichia coli 55989 recombination protein F YP_002405089.1 4255309 R 585055 CDS YP_002405090.1 218697423 7147361 complement(4256382..4257482) 1 NC_011748.1 binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta 4257482 dnaN 7147361 dnaN Escherichia coli 55989 DNA polymerase III subunit beta YP_002405090.1 4256382 R 585055 CDS YP_002405091.1 218697424 7145939 complement(4257487..4258890) 1 NC_011748.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein 4258890 dnaA 7145939 dnaA Escherichia coli 55989 chromosomal replication initiation protein YP_002405091.1 4257487 R 585055 CDS YP_002405092.1 218697425 7145932 4259497..4259637 1 NC_011748.1 in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4259637 rpmH 7145932 rpmH Escherichia coli 55989 50S ribosomal protein L34 YP_002405092.1 4259497 D 585055 CDS YP_002405093.1 218697426 7147493 4259654..4260013 1 NC_011748.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4260013 rnpA 7147493 rnpA Escherichia coli 55989 ribonuclease P YP_002405093.1 4259654 D 585055 CDS YP_002405094.1 218697427 7147453 4259977..4260234 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4260234 yidD 7147453 yidD Escherichia coli 55989 hypothetical protein YP_002405094.1 4259977 D 585055 CDS YP_002405095.1 218697428 7149065 4260237..4261883 1 NC_011748.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 4261883 yidC 7149065 yidC Escherichia coli 55989 inner membrane protein translocase component YidC YP_002405095.1 4260237 D 585055 CDS YP_002405096.1 218697429 7149064 4261989..4263353 1 NC_011748.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 4263353 trmE 7149064 trmE Escherichia coli 55989 tRNA modification GTPase TrmE YP_002405096.1 4261989 D 585055 CDS YP_002405097.1 218697430 7147847 4263596..4263670 1 NC_011748.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; tryptophanase leader peptide 4263670 tnaC 7147847 tnaC Escherichia coli 55989 tryptophanase leader peptide YP_002405097.1 4263596 D 585055 CDS YP_002405098.1 218697431 7147810 4263891..4265306 1 NC_011748.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 4265306 tnaA 7147810 tnaA Escherichia coli 55989 tryptophanase YP_002405098.1 4263891 D 585055 CDS YP_002405099.1 218697432 7147808 4265397..4266644 1 NC_011748.1 tryptophan transporter of low affinity; tryptophan permease TnaB 4266644 tnaB 7147808 tnaB Escherichia coli 55989 tryptophan permease TnaB YP_002405099.1 4265397 D 585055 CDS YP_002405100.1 218697433 7147809 4266777..4267952 1 NC_011748.1 Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 4267952 mdtL 7147809 mdtL Escherichia coli 55989 multidrug efflux system protein MdtL YP_002405100.1 4266777 D 585055 CDS YP_002405101.1 218697434 7146813 4267927..4268886 1 NC_011748.1 Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 4268886 yidZ 7146813 yidZ Escherichia coli 55989 DNA-binding transcriptional regulator YidZ YP_002405101.1 4267927 D 585055 CDS YP_002405102.1 218697435 7149078 4269031..4269792 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; phosphopantetheinyl transferase 4269792 yieE 7149078 yieE Escherichia coli 55989 phosphopantetheinyl transferase YP_002405102.1 4269031 D 585055 CDS YP_002405103.1 218697436 7149079 4269814..4270380 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766567; Product type e : enzyme; chromate reductase, Class I, flavoprotein 4270380 yieF 7149079 yieF Escherichia coli 55989 chromate reductase, Class I, flavoprotein YP_002405103.1 4269814 D 585055 CDS YP_002405104.1 218697437 7149080 complement(4270434..4271771) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4271771 yieG 7149080 yieG Escherichia coli 55989 inner membrane protein YP_002405104.1 4270434 R 585055 CDS YP_002405105.1 218697438 7149081 4271938..4272603 1 NC_011748.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 4272603 yieH 7149081 yieH Escherichia coli 55989 6-phosphogluconate phosphatase YP_002405105.1 4271938 D 585055 CDS YP_002405106.1 218697439 7149082 4272670..4273143 1 NC_011748.1 might be involved in hypersensitivity to nitrofurzone; inner membrane protein 4273143 yieI 7149082 yieI Escherichia coli 55989 inner membrane protein YP_002405106.1 4272670 D 585055 CDS YP_002405107.1 218697440 7149083 4273192..4273779 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4273779 cbrC 7149083 cbrC Escherichia coli 55989 hypothetical protein YP_002405107.1 4273192 D 585055 CDS YP_002405108.1 218697441 7145670 complement(4273841..4274563) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; 6-phosphogluconolactonase 4274563 yieK 7145670 yieK Escherichia coli 55989 6-phosphogluconolactonase YP_002405108.1 4273841 R 585055 CDS YP_002405109.1 218697442 7149084 complement(4274578..4275774) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; xylanase 4275774 yieL 7149084 yieL Escherichia coli 55989 xylanase YP_002405109.1 4274578 R 585055 CDS YP_002405110.1 218697443 7149085 complement(4275774..4277390) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10027967; Product type t : transporter; carbohydrate-specific outer membrane porin, cryptic 4277390 bglH 7149085 bglH Escherichia coli 55989 carbohydrate-specific outer membrane porin, cryptic YP_002405110.1 4275774 R 585055 CDS YP_002405111.1 218697444 7145621 complement(4277476..4278870) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140, 3034860, 3309161; Product type e : enzyme; cryptic phospho-beta-glucosidase B 4278870 bglB 7145621 bglB Escherichia coli 55989 cryptic phospho-beta-glucosidase B YP_002405111.1 4277476 R 585055 CDS YP_002405112.1 218697445 7145617 complement(4278889..4280766) 1 NC_011748.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system beta-glucoside-specific transporter subunit IIABC 4280766 bglF 7145617 bglF Escherichia coli 55989 PTS system beta-glucoside-specific transporter subunit IIABC YP_002405112.1 4278889 R 585055 CDS YP_002405113.1 218697446 7145620 complement(4282022..4282747) 1 NC_011748.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU 4282747 phoU 7145620 phoU Escherichia coli 55989 transcriptional regulator PhoU YP_002405113.1 4282022 R 585055 CDS YP_002405114.1 218697447 7147186 complement(4282762..4283535) 1 NC_011748.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein 4283535 pstB 7147186 pstB Escherichia coli 55989 phosphate transporter ATP-binding protein YP_002405114.1 4282762 R 585055 CDS YP_002405115.1 218697448 7147278 complement(4283626..4284516) 1 NC_011748.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA 4284516 pstA 7147278 pstA Escherichia coli 55989 phosphate transporter permease subunit PtsA YP_002405115.1 4283626 R 585055 CDS YP_002405116.1 218697449 7147277 complement(4284516..4285475) 1 NC_011748.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC 4285475 pstC 7147277 pstC Escherichia coli 55989 phosphate transporter permease subunit PstC YP_002405116.1 4284516 R 585055 CDS YP_002405117.1 218697450 7147279 complement(4285562..4286602) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90133909, 2215649, 6321434, 6365894, 9228942, 9298646, 9671506; Product type t : transporter; phosphate ABC transporter substrate-binding protein 4286602 pstS 7147279 pstS Escherichia coli 55989 phosphate ABC transporter substrate-binding protein YP_002405117.1 4285562 R 585055 CDS YP_002405118.1 218697451 7147280 complement(4286850..4287923) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12438351, 7721701, 16128397; Product type ps : structure; fimbrial protein LpfD; adhesin 4287923 lpfD 7147280 lpfD Escherichia coli 55989 fimbrial protein LpfD; adhesin YP_002405118.1 4286850 R 585055 CDS YP_002405119.1 218697452 7146729 complement(4287934..4290456) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7721701, 16128397; Product type pt : transporter; fimbrial usher 4290456 lpfC 7146729 lpfC Escherichia coli 55989 fimbrial usher YP_002405119.1 4287934 R 585055 CDS YP_002405120.1 218697453 7146727 complement(4290481..4291212) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16128397, 12438351; Product type pc : carrier; fimbrial chaperone protein 4291212 lfpB 7146727 lfpB Escherichia coli 55989 fimbrial chaperone protein YP_002405120.1 4290481 R 585055 CDS YP_002405121.1 218697454 7146697 complement(4291260..4291832) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16125910, 12438351; Product type ps : structure; major fimbrial subunit 4291832 lpfA 7146697 lpfA Escherichia coli 55989 major fimbrial subunit YP_002405121.1 4291260 R 585055 CDS YP_002405122.1 218697455 7146724 complement(4292134..4293963) 1 NC_011748.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase 4293963 glmS 7146724 glmS Escherichia coli 55989 glucosamine--fructose-6-phosphate aminotransferase YP_002405122.1 4292134 R 585055 CDS YP_002405123.1 218697456 7146300 complement(4294125..4295495) 1 NC_011748.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase 4295495 glmU 7146300 glmU Escherichia coli 55989 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase YP_002405123.1 4294125 R 585055 CDS YP_002405124.1 218697457 7146301 complement(4295846..4296265) 1 NC_011748.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon 4296265 atpC 7146301 atpC Escherichia coli 55989 ATP synthase F0F1 subunit epsilon YP_002405124.1 4295846 R 585055 CDS YP_002405125.1 218697458 7145582 complement(4296286..4297668) 1 NC_011748.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta 4297668 atpD 7145582 atpD Escherichia coli 55989 ATP synthase F0F1 subunit beta YP_002405125.1 4296286 R 585055 CDS YP_002405126.1 218697459 7145583 complement(4297695..4298558) 1 NC_011748.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma 4298558 atpG 7145583 atpG Escherichia coli 55989 ATP synthase F0F1 subunit gamma YP_002405126.1 4297695 R 585055 CDS YP_002405127.1 218697460 7145586 complement(4298609..4300150) 1 NC_011748.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha 4300150 atpA 7145586 atpA Escherichia coli 55989 ATP synthase F0F1 subunit alpha YP_002405127.1 4298609 R 585055 CDS YP_002405128.1 218697461 7145580 complement(4300163..4300696) 1 NC_011748.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta 4300696 atpH 7145580 atpH Escherichia coli 55989 ATP synthase F0F1 subunit delta YP_002405128.1 4300163 R 585055 CDS YP_002405129.1 218697462 7145587 complement(4300711..4301181) 1 NC_011748.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B 4301181 atpF 7145587 atpF Escherichia coli 55989 ATP synthase F0F1 subunit B YP_002405129.1 4300711 R 585055 CDS YP_002405130.1 218697463 7145585 complement(4301243..4301482) 1 NC_011748.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C 4301482 atpE 7145585 atpE Escherichia coli 55989 ATP synthase F0F1 subunit C YP_002405130.1 4301243 R 585055 CDS YP_002405131.1 218697464 7145584 complement(4301529..4302344) 1 NC_011748.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A 4302344 atpB 7145584 atpB Escherichia coli 55989 ATP synthase F0F1 subunit A YP_002405131.1 4301529 R 585055 CDS YP_002405132.1 218697465 7145581 complement(4302353..4302733) 1 NC_011748.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I 4302733 atpI 7145581 atpI Escherichia coli 55989 F0F1 ATP synthase subunit I YP_002405132.1 4302353 R 585055 CDS YP_002405133.1 218697466 7145588 complement(4303350..4303973) 1 NC_011748.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB 4303973 gidB 7145588 gidB Escherichia coli 55989 16S rRNA methyltransferase GidB YP_002405133.1 4303350 R 585055 CDS YP_002405134.1 218697467 7146284 complement(4304037..4305926) 1 NC_011748.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA 4305926 gidA 7146284 gidA Escherichia coli 55989 tRNA uridine 5-carboxymethylaminomethyl modification protein GidA YP_002405134.1 4304037 R 585055 CDS YP_002405135.1 218697468 7146283 complement(4306305..4306748) 1 NC_011748.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin 4306748 mioC 7146283 mioC Escherichia coli 55989 flavodoxin YP_002405135.1 4306305 R 585055 CDS YP_002405136.1 218697469 7146860 complement(4306838..4307296) 1 NC_011748.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC 4307296 asnC 7146860 asnC Escherichia coli 55989 DNA-binding transcriptional regulator AsnC YP_002405136.1 4306838 R 585055 CDS YP_002405137.1 218697470 7145569 4307448..4308440 1 NC_011748.1 catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4308440 asnA 7145569 asnA Escherichia coli 55989 asparagine synthetase AsnA YP_002405137.1 4307448 D 585055 CDS YP_002405138.1 218697471 7145567 complement(4308445..4309896) 1 NC_011748.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein 4309896 yieM 7145567 yieM Escherichia coli 55989 hypothetical protein YP_002405138.1 4308445 R 585055 CDS YP_002405139.1 218697472 7149086 complement(4309890..4311386) 1 NC_011748.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA 4311386 ravA 7149086 ravA Escherichia coli 55989 regulatory ATPase RavA YP_002405139.1 4309890 R 585055 CDS YP_002405140.1 218697473 7147337 4311609..4313477 1 NC_011748.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4313477 trkD 7147337 trkD Escherichia coli 55989 potassium transport protein Kup YP_002405140.1 4311609 D 585055 CDS YP_002405141.1 218697474 7147842 4313644..4314063 1 NC_011748.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4314063 rbsD 7147842 rbsD Escherichia coli 55989 D-ribose pyranase YP_002405141.1 4313644 D 585055 CDS YP_002405142.1 218697475 7147344 4314071..4315576 1 NC_011748.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP-binding protein 4315576 rbsA 7147344 rbsA Escherichia coli 55989 D-ribose transporter ATP-binding protein YP_002405142.1 4314071 D 585055 CDS YP_002405143.1 218697476 7147341 4315581..4316546 1 NC_011748.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4316546 rbsC 7147341 rbsC Escherichia coli 55989 ribose ABC transporter permease YP_002405143.1 4315581 D 585055 CDS YP_002405144.1 218697477 7147343 4316571..4317461 1 NC_011748.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4317461 rbsB 7147343 rbsB Escherichia coli 55989 D-ribose transporter subunit RbsB YP_002405144.1 4316571 D 585055 CDS YP_002405145.1 218697478 7147342 4317587..4318516 1 NC_011748.1 catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4318516 rbsK 7147342 rbsK Escherichia coli 55989 ribokinase YP_002405145.1 4317587 D 585055 CDS YP_002405146.1 218697479 7147345 4318520..4319512 1 NC_011748.1 DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4319512 rbsR 7147345 rbsR Escherichia coli 55989 transcriptional repressor RbsR YP_002405146.1 4318520 D 585055 CDS YP_002405147.1 218697480 7147346 complement(4319478..4320905) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 20218988, 12107133; Product type t : transporter; multidrug or homocysteine efflux system 4320905 hsrA 7147346 hsrA Escherichia coli 55989 multidrug or homocysteine efflux system YP_002405147.1 4319478 R 585055 CDS YP_002405148.1 218697481 7146472 complement(4320928..4321620) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 4321620 yieP 7146472 yieP Escherichia coli 55989 transcriptional regulator YP_002405148.1 4320928 R 585055 CDS YP_002405149.1 218697482 7145349 complement(4327421..4328260) 1 NC_011748.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR 4328260 hdfR 7145349 hdfR Escherichia coli 55989 transcriptional regulator HdfR YP_002405149.1 4327421 R 585055 CDS YP_002405150.1 218697483 7146404 4328379..4328717 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4328717 yifE 7146404 yifE Escherichia coli 55989 hypothetical protein YP_002405150.1 4328379 D 585055 CDS YP_002405151.1 218697484 7149089 complement(4328742..4330292) 1 NC_011748.1 among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function; ATP-dependent protease 4330292 yifB 7149089 yifB Escherichia coli 55989 ATP-dependent protease YP_002405151.1 4328742 R 585055 CDS YP_002405152.1 218697485 7149088 4330615..4330713 1 NC_011748.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; ilvG operon leader peptide 4330713 ilvL 7149088 ilvL Escherichia coli 55989 ilvG operon leader peptide YP_002405152.1 4330615 D 585055 CDS YP_002405153.1 218697486 7146557 4330853..4332499 1 NC_011748.1 catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 4332499 ilvG 7146557 ilvG Escherichia coli 55989 acetolactate synthase 2 catalytic subunit YP_002405153.1 4330853 D 585055 CDS YP_002405154.1 218697487 7146554 4332496..4332759 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92332418, 92380929, 1569580, 3550695, 3897211; Product type e : enzyme; acetolactate synthase 2 regulatory subunit 4332759 ilvM 7146554 ilvM Escherichia coli 55989 acetolactate synthase 2 regulatory subunit YP_002405154.1 4332496 D 585055 CDS YP_002405155.1 218697488 7146558 4332779..4333708 1 NC_011748.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 4333708 ilvE 7146558 ilvE Escherichia coli 55989 branched-chain amino acid aminotransferase YP_002405155.1 4332779 D 585055 CDS YP_002405156.1 218697489 7146553 4333773..4335623 1 NC_011748.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 4335623 ilvD 7146553 ilvD Escherichia coli 55989 dihydroxy-acid dehydratase YP_002405156.1 4333773 D 585055 CDS YP_002405157.1 218697490 7146552 4335626..4337170 1 NC_011748.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 4337170 ilvA 7146552 ilvA Escherichia coli 55989 threonine dehydratase YP_002405157.1 4335626 D 585055 CDS YP_002405158.1 218697491 7146549 complement(4337222..4338115) 1 NC_011748.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY 4338115 ilvY 7146549 ilvY Escherichia coli 55989 DNA-binding transcriptional regulator IlvY YP_002405158.1 4337222 R 585055 CDS YP_002405159.1 218697492 7146562 4338265..4339740 1 NC_011748.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 4339740 ilvC 7146562 ilvC Escherichia coli 55989 ketol-acid reductoisomerase YP_002405159.1 4338265 D 585055 CDS YP_002405160.1 218697493 7146551 complement(4339827..4340108) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94215709, 7878732, 7925971, 8163020; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase C 4340108 ppiC 7146551 ppiC Escherichia coli 55989 peptidyl-prolyl cis-trans isomerase C YP_002405160.1 4339827 R 585055 CDS YP_002405161.1 218697494 7147230 complement(4340307..4340798) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4340798 7147230 EC55989_4248 Escherichia coli 55989 hypothetical protein YP_002405161.1 4340307 R 585055 CDS YP_002405162.1 218697495 7145070 4340973..4342994 1 NC_011748.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 4342994 rep 7145070 rep Escherichia coli 55989 ATP-dependent DNA helicase Rep YP_002405162.1 4340973 D 585055 CDS YP_002405163.1 218697496 7147373 complement(4343041..4344525) 1 NC_011748.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase 4344525 gpp 7147373 gpp Escherichia coli 55989 guanosine pentaphosphate phosphohydrolase YP_002405163.1 4343041 R 585055 CDS YP_002405164.1 218697497 7146362 complement(4344659..4345924) 1 NC_011748.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB 4345924 rhlB 7146362 rhlB Escherichia coli 55989 ATP-dependent RNA helicase RhlB YP_002405164.1 4344659 R 585055 CDS YP_002405165.1 218697498 7147396 4346055..4346384 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 91154193, 92250497, 99175138, 10489448, 1094461, 10947986, 1561103, 2181145, 2193685, 3891733, 4616096, 4883076, 6098320, 6099324, 7812718, 8098620, 8253691; Product type c : carrier; thioredoxin 4346384 trxA 7147396 trxA Escherichia coli 55989 thioredoxin YP_002405165.1 4346055 D 585055 CDS YP_002405166.1 218697499 7147862 4346525..4346626 1 NC_011748.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; rho operon leader peptide 4346626 rhoL 7147862 rhoL Escherichia coli 55989 rho operon leader peptide YP_002405166.1 4346525 D 585055 CDS YP_002405167.1 218697500 7147399 4346711..4347970 1 NC_011748.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4347970 rho 7147399 rho Escherichia coli 55989 transcription termination factor Rho YP_002405167.1 4346711 D 585055 CDS YP_002405168.1 218697501 7147398 4347980..4348198 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4348198 7147398 EC55989_4255 Escherichia coli 55989 hypothetical protein YP_002405168.1 4347980 D 585055 CDS YP_002405169.1 218697502 7145071 4348210..4349313 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92114763, 94245613, 94292435, 10629198, 11024259, 11700352, 11832520, 1722555, 1730666; Product type e : enzyme; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 4349313 rfe 7145071 rfe Escherichia coli 55989 UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase YP_002405169.1 4348210 D 585055 CDS YP_002405170.1 218697503 7147381 4349325..4350371 1 NC_011748.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 4350371 wzzE 7147381 wzzE Escherichia coli 55989 lipopolysaccharide biosynthesis protein WzzE YP_002405170.1 4349325 D 585055 CDS YP_002405171.1 218697504 7147980 4350427..4351557 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 94042873, 11106477, 7559340, 8170390, 8226648; Product type e : enzyme; UDP-N-acetyl glucosamine-2-epimerase 4351557 rffE 7147980 rffE Escherichia coli 55989 UDP-N-acetyl glucosamine-2-epimerase YP_002405171.1 4350427 D 585055 CDS YP_002405172.1 218697505 7147385 4351554..4352816 1 NC_011748.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 4352816 wecC 7147385 wecC Escherichia coli 55989 UDP-N-acetyl-D-mannosamine dehydrogenase YP_002405172.1 4351554 D 585055 CDS YP_002405173.1 218697506 7147384 4352816..4353883 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086930, 90212314, 90337949, 92112804, 92174908, 94018634, 94042873, 7559340; Product type e : enzyme; dTDP-glucose 4,6-dehydratase 4353883 rffG 7147384 rffG Escherichia coli 55989 dTDP-glucose 4,6-dehydratase YP_002405173.1 4352816 D 585055 CDS YP_002405174.1 218697507 7147386 4353902..4354783 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292435, 96032389; Product type e : enzyme; glucose-1-phosphate thymidylyltransferase 4354783 rffH 7147386 rffH Escherichia coli 55989 glucose-1-phosphate thymidylyltransferase YP_002405174.1 4353902 D 585055 CDS YP_002405175.1 218697508 7147387 4354761..4355435 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 8366065; Product type e : enzyme; TDP-fucosamine acetyltransferase 4355435 rffC 7147387 rffC Escherichia coli 55989 TDP-fucosamine acetyltransferase YP_002405175.1 4354761 D 585055 CDS YP_002405176.1 218697509 7147383 4355440..4356570 1 NC_011748.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4356570 rffA 7147383 rffA Escherichia coli 55989 TDP-4-oxo-6-deoxy-D-glucose transaminase YP_002405176.1 4355440 D 585055 CDS YP_002405177.1 218697510 7147382 4356572..4357822 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12621029, 20044778; Product type t : transporter; O-antigen translocase 4357822 wzxE 7147382 wzxE Escherichia coli 55989 O-antigen translocase YP_002405177.1 4356572 D 585055 CDS YP_002405178.1 218697511 7147978 4357819..4358898 1 NC_011748.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4358898 rffT 7147978 rffT Escherichia coli 55989 4-alpha-L-fucosyltransferase YP_002405178.1 4357819 D 585055 CDS YP_002405179.1 218697512 7147389 4358895..4360247 1 NC_011748.1 enterobacterial common antigen polymerase; common antigen polymerase 4360247 wzyE 7147389 wzyE Escherichia coli 55989 common antigen polymerase YP_002405179.1 4358895 D 585055 CDS YP_002405180.1 218697513 7147979 4360250..4360990 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086874, 90337949, 92112804; Product type e : enzyme; UDP-N-acetyl-D-mannosaminuronic acid transferase 4360990 rffM 7147979 rffM Escherichia coli 55989 UDP-N-acetyl-D-mannosaminuronic acid transferase YP_002405180.1 4360250 D 585055 CDS YP_002405181.1 218697514 7147388 4361181..4362566 1 NC_011748.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; transporter 4362566 yifK 7147388 yifK Escherichia coli 55989 transporter YP_002405181.1 4361181 D 585055 CDS YP_002405182.1 218697515 7145354 4363252..4364487 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11222759, 2180918, 12419807, 14749327; Product type pr : regulator; regulator of arylsulfatase activity 4364487 aslB 7145354 aslB Escherichia coli 55989 regulator of arylsulfatase activity YP_002405182.1 4363252 D 585055 CDS YP_002405183.1 218697516 7147593 complement(4365411..4366607) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89041586; Product type pe : enzyme; protoheme IX biogenesis protein 4366607 hemY 7147593 hemY Escherichia coli 55989 protoheme IX biogenesis protein YP_002405183.1 4365411 R 585055 CDS YP_002405184.1 218697517 7146418 complement(4366610..4367815) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89098348, 92358234, 3054815, 3062586, 9298646; Product type pe : enzyme; uroporphyrinogen III C-methyltransferase 4367815 hemX 7146418 hemX Escherichia coli 55989 uroporphyrinogen III C-methyltransferase YP_002405184.1 4366610 R 585055 CDS YP_002405185.1 218697518 7146417 complement(4367837..4368577) 1 NC_011748.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase 4368577 hemD 7146417 hemD Escherichia coli 55989 uroporphyrinogen-III synthase YP_002405185.1 4367837 R 585055 CDS YP_002405186.1 218697519 7146410 complement(4368574..4369515) 1 NC_011748.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase 4369515 hemC 7146410 hemC Escherichia coli 55989 porphobilinogen deaminase YP_002405186.1 4368574 R 585055 CDS YP_002405187.1 218697520 7146409 4369902..4372448 1 NC_011748.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4372448 cyaA 7146409 cyaA Escherichia coli 55989 adenylate cyclase YP_002405187.1 4369902 D 585055 CDS YP_002405188.1 218697521 7145802 complement(4372488..4372808) 1 NC_011748.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein 4372808 cyaY 7145802 cyaY Escherichia coli 55989 frataxin-like protein YP_002405188.1 4372488 R 585055 CDS YP_002405189.1 218697522 7145803 complement(4372856..4374181) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4374181 7145803 EC55989_4278 Escherichia coli 55989 hypothetical protein YP_002405189.1 4372856 R 585055 CDS YP_002405190.1 218697523 7145072 complement(4374178..4375686) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4375686 7145072 EC55989_4279 Escherichia coli 55989 hypothetical protein YP_002405190.1 4374178 R 585055 CDS YP_002405191.1 218697524 7145073 complement(4376024..4376578) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4376578 7145073 EC55989_4280 Escherichia coli 55989 hypothetical protein YP_002405191.1 4376024 R 585055 CDS YP_002405192.1 218697525 7145074 complement(4376585..4376719) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 4376719 7145074 EC55989_4281 Escherichia coli 55989 hypothetical protein YP_002405192.1 4376585 R 585055 CDS YP_002405193.1 218697526 7145075 4376928..4377131 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; lipoprotein 4377131 yifL 7145075 yifL Escherichia coli 55989 lipoprotein YP_002405193.1 4376928 D 585055 CDS YP_002405194.1 218697527 7149091 4377168..4377992 1 NC_011748.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4377992 dapF 7149091 dapF Escherichia coli 55989 diaminopimelate epimerase YP_002405194.1 4377168 D 585055 CDS YP_002405195.1 218697528 7145853 4377989..4378696 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4378696 yigA 7145853 yigA Escherichia coli 55989 hypothetical protein YP_002405195.1 4377989 D 585055 CDS YP_002405196.1 218697529 7149092 4378693..4379589 1 NC_011748.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4379589 xerC 7149092 xerC Escherichia coli 55989 site-specific tyrosine recombinase XerC YP_002405196.1 4378693 D 585055 CDS YP_002405197.1 218697530 7147989 4379589..4380305 1 NC_011748.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4380305 yigB 7147989 yigB Escherichia coli 55989 flavin mononucleotide phosphatase YP_002405197.1 4379589 D 585055 CDS YP_002405198.1 218697531 7149093 4380389..4382551 1 NC_011748.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4382551 uvrD 7149093 uvrD Escherichia coli 55989 DNA-dependent helicase II YP_002405198.1 4380389 D 585055 CDS YP_002405199.1 218697532 7147936 complement(4382698..4383462) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4383462 yigE 7147936 yigE Escherichia coli 55989 hypothetical protein YP_002405199.1 4382698 R 585055 CDS YP_002405200.1 218697533 7149094 4383832..4384782 1 NC_011748.1 responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4384782 corA 7149094 corA Escherichia coli 55989 magnesium/nickel/cobalt transporter CorA YP_002405200.1 4383832 D 585055 CDS YP_002405201.1 218697534 7145743 complement(4384824..4385315) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4385315 7145743 EC55989_4290 Escherichia coli 55989 hypothetical protein YP_002405201.1 4384824 R 585055 CDS YP_002405202.1 218697535 7145076 complement(4385312..4386166) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4386166 7145076 EC55989_4291 Escherichia coli 55989 hypothetical protein YP_002405202.1 4385312 R 585055 CDS YP_002405203.1 218697536 7145077 4386290..4386493 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4386493 7145077 EC55989_4292 Escherichia coli 55989 hypothetical protein YP_002405203.1 4386290 D 585055 CDS YP_002405204.1 218697537 7145078 complement(4386518..4386796) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4386796 7145078 EC55989_4293 Escherichia coli 55989 hypothetical protein YP_002405204.1 4386518 R 585055 CDS YP_002405205.1 218697538 7145079 4386573..4386689 1 NC_011748.1 hypothetical protein 4386689 7145079 EC55989_4294 Escherichia coli 55989 hypothetical protein YP_002405205.1 4386573 D 585055 CDS YP_002405206.1 218697539 7145080 4387076..4387420 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; membrane protein 4387420 7145080 EC55989_4295 Escherichia coli 55989 membrane protein YP_002405206.1 4387076 D 585055 CDS YP_002405207.1 218697540 7145081 complement(4387467..4388354) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; chloramphenicol resistance permease 4388354 rarD 7145081 rarD Escherichia coli 55989 chloramphenicol resistance permease YP_002405207.1 4387467 R 585055 CDS YP_002405208.1 218697541 7147336 complement(4388406..4388873) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4388873 yigI 7147336 yigI Escherichia coli 55989 hypothetical protein YP_002405208.1 4388406 R 585055 CDS YP_002405209.1 218697542 7149095 4389038..4389907 1 NC_011748.1 catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4389907 pldA 7149095 pldA Escherichia coli 55989 phospholipase A YP_002405209.1 4389038 D 585055 CDS YP_002405210.1 218697543 7147193 4390040..4391869 1 NC_011748.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4391869 recQ 7147193 recQ Escherichia coli 55989 ATP-dependent DNA helicase RecQ YP_002405210.1 4390040 D 585055 CDS YP_002405211.1 218697544 7147366 4391933..4392553 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596, 3027506; Product type t : transporter; threonine efflux system 4392553 rhtC 7147366 rhtC Escherichia coli 55989 threonine efflux system YP_002405211.1 4391933 D 585055 CDS YP_002405212.1 218697545 7147408 complement(4392615..4393235) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596; Product type t : transporter; homoserine/homoserine lactone efflux protein 4393235 rhtB 7147408 rhtB Escherichia coli 55989 homoserine/homoserine lactone efflux protein YP_002405212.1 4392615 R 585055 CDS YP_002405213.1 218697546 7147407 4393346..4394368 1 NC_011748.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4394368 pldB 7147407 pldB Escherichia coli 55989 lysophospholipase L2 YP_002405213.1 4393346 D 585055 CDS YP_002405214.1 218697547 7147194 4394376..4395176 1 NC_011748.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; sugar phosphatase 4395176 yigL 7147194 yigL Escherichia coli 55989 sugar phosphatase YP_002405214.1 4394376 D 585055 CDS YP_002405215.1 218697548 7149096 4395252..4396151 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4396151 yigM 7149096 yigM Escherichia coli 55989 inner membrane protein YP_002405215.1 4395252 D 585055 CDS YP_002405216.1 218697549 7149097 complement(4396039..4396992) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90384950, 96303520, 2205852, 2643109; Product type r : regulator; DNA-binding transcriptional activator, homocysteine-binding 4396992 metR 7149097 metR Escherichia coli 55989 DNA-binding transcriptional activator, homocysteine-binding YP_002405216.1 4396039 R 585055 CDS YP_002405217.1 218697550 7146837 4397110..4399371 1 NC_011748.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 4399371 metE 7146837 metE Escherichia coli 55989 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase YP_002405217.1 4397110 D 585055 CDS YP_002405218.1 218697551 7146827 complement(4399410..4400225) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12676709; Product type pe : enzyme; hydrolase 4400225 ysgA 7146827 ysgA Escherichia coli 55989 hydrolase YP_002405218.1 4399410 R 585055 CDS YP_002405219.1 218697552 7149468 4400487..4401248 1 NC_011748.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4401248 udp 7149468 udp Escherichia coli 55989 uridine phosphorylase YP_002405219.1 4400487 D 585055 CDS YP_002405220.1 218697553 7147898 4401389..4402816 1 NC_011748.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4402816 rmuC 7147898 rmuC Escherichia coli 55989 DNA recombination protein RmuC YP_002405220.1 4401389 D 585055 CDS YP_002405221.1 218697554 7147431 4402911..4403666 1 NC_011748.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4403666 ubiE 7147431 ubiE Escherichia coli 55989 ubiquinone/menaquinone biosynthesis methyltransferase YP_002405221.1 4402911 D 585055 CDS YP_002405222.1 218697555 7147891 4403680..4404285 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4404285 yigP 7147891 yigP Escherichia coli 55989 hypothetical protein YP_002405222.1 4403680 D 585055 CDS YP_002405223.1 218697556 7149098 4404282..4405922 1 NC_011748.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 4405922 ubiB 7149098 ubiB Escherichia coli 55989 ubiquinone biosynthesis protein UbiB YP_002405223.1 4404282 D 585055 CDS YP_002405224.1 218697557 7147888 4406001..4406270 1 NC_011748.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 4406270 tatA 7147888 tatA Escherichia coli 55989 twin arginine translocase protein A YP_002405224.1 4406001 D 585055 CDS YP_002405225.1 218697558 7147753 4406274..4406789 1 NC_011748.1 mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4406789 tatB 7147753 tatB Escherichia coli 55989 sec-independent translocase YP_002405225.1 4406274 D 585055 CDS YP_002405226.1 218697559 7147754 4406792..4407568 1 NC_011748.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4407568 tatC 7147754 tatC Escherichia coli 55989 twin-arginine protein translocation system subunit TatC YP_002405226.1 4406792 D 585055 CDS YP_002405227.1 218697560 7147755 4407610..4408392 1 NC_011748.1 magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4408392 tatD 7147755 tatD Escherichia coli 55989 DNase TatD YP_002405227.1 4407610 D 585055 CDS YP_002405228.1 218697561 7147756 complement(4408389..4408877) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92011415, 92250420, 92261317, 1584020, 12007406; Product type r : regulator; transcriptional activator RfaH 4408877 rfaH 7147756 rfaH Escherichia coli 55989 transcriptional activator RfaH YP_002405228.1 4408389 R 585055 CDS YP_002405229.1 218697562 7147375 4409044..4410537 1 NC_011748.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 4410537 ubiD 7147375 ubiD Escherichia coli 55989 3-octaprenyl-4-hydroxybenzoate carboxy-lyase YP_002405229.1 4409044 D 585055 CDS YP_002405230.1 218697563 7147890 4410583..4411284 1 NC_011748.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4411284 fre 7147890 fre Escherichia coli 55989 FMN reductase YP_002405230.1 4410583 D 585055 CDS YP_002405231.1 218697564 7146183 complement(4411476..4412639) 1 NC_011748.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase 4412639 fadA 7146183 fadA Escherichia coli 55989 3-ketoacyl-CoA thiolase YP_002405231.1 4411476 R 585055 CDS YP_002405232.1 218697565 7146055 complement(4412649..4414838) 1 NC_011748.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha 4414838 fadB 7146055 fadB Escherichia coli 55989 multifunctional fatty acid oxidation complex subunit alpha YP_002405232.1 4412649 R 585055 CDS YP_002405233.1 218697566 7146056 4415028..4416359 1 NC_011748.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4416359 pepQ 7146056 pepQ Escherichia coli 55989 proline dipeptidase YP_002405233.1 4415028 D 585055 CDS YP_002405234.1 218697567 7147136 4416359..4416973 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15103642; Product type pf : factor; hypothetical protein 4416973 yigZ 7147136 yigZ Escherichia coli 55989 hypothetical protein YP_002405234.1 4416359 D 585055 CDS YP_002405235.1 218697568 7149099 4417012..4418463 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100357, 2243799, 7896723; Product type t : transporter; potassium transporter 4418463 trkH 7149099 trkH Escherichia coli 55989 potassium transporter YP_002405235.1 4417012 D 585055 CDS YP_002405236.1 218697569 7147843 4418475..4419020 1 NC_011748.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4419020 hemG 7147843 hemG Escherichia coli 55989 protoporphyrinogen oxidase YP_002405236.1 4418475 D 585055 CDS YP_002405237.1 218697570 7145292 complement(4424604..4425116) 1 NC_011748.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B 4425116 mobB 7145292 mobB Escherichia coli 55989 molybdopterin-guanine dinucleotide biosynthesis protein B YP_002405237.1 4424604 R 585055 CDS YP_002405238.1 218697571 7146878 complement(4425113..4425697) 1 NC_011748.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA 4425697 mobA 7146878 mobA Escherichia coli 55989 molybdopterin-guanine dinucleotide biosynthesis protein MobA YP_002405238.1 4425113 R 585055 CDS YP_002405239.1 218697572 7146877 4425767..4426036 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4426036 yihD 7146877 yihD Escherichia coli 55989 hypothetical protein YP_002405239.1 4425767 D 585055 CDS YP_002405240.1 218697573 7149101 4426113..4427099 1 NC_011748.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4427099 yihE 7149101 yihE Escherichia coli 55989 serine/threonine protein kinase YP_002405240.1 4426113 D 585055 CDS YP_002405241.1 218697574 7149102 4427116..4427742 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12498799, 93264419, 94016574, 94206930, 99298180, 10210188, 1429594, 1740115, 1934062, 8413591, 8494885, 8521518, 9194175, 9298646, 9300489, 9572841, 9600841, 9655827; Product type e : enzyme; protein disulfide isomerase I 4427742 dsbA 7149102 dsbA Escherichia coli 55989 protein disulfide isomerase I YP_002405241.1 4427116 D 585055 CDS YP_002405242.1 218697575 7145950 4427897..4429327 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4429327 yihF 7145950 yihF Escherichia coli 55989 hypothetical protein YP_002405242.1 4427897 D 585055 CDS YP_002405243.1 218697576 7149103 complement(4429368..4430300) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acyltransferase 4430300 yihG 7149103 yihG Escherichia coli 55989 acyltransferase YP_002405243.1 4429368 R 585055 CDS YP_002405244.1 218697577 7149104 4430664..4433450 1 NC_011748.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4433450 polA 7149104 polA Escherichia coli 55989 DNA polymerase I YP_002405244.1 4430664 D 585055 CDS YP_002405245.1 218697578 7147692 complement(4433832..4434428) 1 NC_011748.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC 4434428 engB 7147692 engB Escherichia coli 55989 ribosome biogenesis GTP-binding protein YsxC YP_002405245.1 4433832 R 585055 CDS YP_002405246.1 218697579 7145785 4435046..4435555 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4435555 yihI 7145785 yihI Escherichia coli 55989 hypothetical protein YP_002405246.1 4435046 D 585055 CDS YP_002405247.1 218697580 7149105 4435744..4437117 1 NC_011748.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4437117 hemN 7149105 hemN Escherichia coli 55989 coproporphyrinogen III oxidase YP_002405247.1 4435744 D 585055 CDS YP_002405248.1 218697581 7146416 complement(4437529..4438938) 1 NC_011748.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) 4438938 glnG 7146416 glnG Escherichia coli 55989 nitrogen regulation protein NR(I) YP_002405248.1 4437529 R 585055 CDS YP_002405249.1 218697582 7146306 complement(4438950..4439999) 1 NC_011748.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) 4439999 glnL 7146306 glnL Escherichia coli 55989 nitrogen regulation protein NR(II) YP_002405249.1 4438950 R 585055 CDS YP_002405250.1 218697583 7146309 complement(4440285..4441694) 1 NC_011748.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase 4441694 glnA 7146309 glnA Escherichia coli 55989 glutamine synthetase YP_002405250.1 4440285 R 585055 CDS YP_002405251.1 218697584 7146302 complement(4441822..4441974) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4441974 7146302 EC55989_4346 Escherichia coli 55989 hypothetical protein YP_002405251.1 4441822 R 585055 CDS YP_002405252.1 218697585 7145082 4442067..4443890 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642082, 7783627, 9298646, 9622352; Product type f : factor; GTP-binding protein 4443890 bipA 7145082 bipA Escherichia coli 55989 GTP-binding protein YP_002405252.1 4442067 D 585055 CDS YP_002405253.1 218697586 7145630 4444106..4444816 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 4444816 yihL 7145630 yihL Escherichia coli 55989 DNA-binding transcriptional regulator YP_002405253.1 4444106 D 585055 CDS YP_002405254.1 218697587 7149106 4444824..4445804 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; sugar phosphate isomerase 4445804 yihM 7149106 yihM Escherichia coli 55989 sugar phosphate isomerase YP_002405254.1 4444824 D 585055 CDS YP_002405255.1 218697588 7149107 4445906..4447171 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4447171 yihN 7149107 yihN Escherichia coli 55989 transporter YP_002405255.1 4445906 D 585055 CDS YP_002405256.1 218697589 7149108 complement(4447282..4448070) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DEOR-type transcriptional regulator 4448070 7149108 EC55989_4351 Escherichia coli 55989 DEOR-type transcriptional regulator YP_002405256.1 4447282 R 585055 CDS YP_002405257.1 218697590 7145083 complement(4448110..4449045) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; sugar kinase 4449045 7145083 EC55989_4352 Escherichia coli 55989 sugar kinase YP_002405257.1 4448110 R 585055 CDS YP_002405258.1 218697591 7145084 4448978..4450057 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase with NAD(P)-binding Rossmann-fold domain, 3-hydroxyisobutyrate dehydrogenase 4450057 7145084 EC55989_4353 Escherichia coli 55989 oxidoreductase with NAD(P)-binding Rossmann-fold domain, 3-hydroxyisobutyrate dehydrogenase YP_002405258.1 4448978 D 585055 CDS YP_002405259.1 218697592 7145085 4450082..4450969 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; aldolase yihT 4450969 7145085 EC55989_4354 Escherichia coli 55989 aldolase yihT YP_002405259.1 4450082 D 585055 CDS YP_002405260.1 218697593 7145086 4451002..4452012 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; dehydrogenase, GroES-like protein 4452012 7145086 EC55989_4355 Escherichia coli 55989 dehydrogenase, GroES-like protein YP_002405260.1 4451002 D 585055 CDS YP_002405261.1 218697594 7145087 4452082..4453515 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4453515 7145087 EC55989_4356 Escherichia coli 55989 transporter YP_002405261.1 4452082 D 585055 CDS YP_002405262.1 218697595 7145088 4453614..4454963 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transport protein 4454963 7145088 EC55989_4357 Escherichia coli 55989 transport protein YP_002405262.1 4453614 D 585055 CDS YP_002405263.1 218697596 7145089 4454896..4455840 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; galactose mutarotase 4455840 7145089 EC55989_4358 Escherichia coli 55989 galactose mutarotase YP_002405263.1 4454896 D 585055 CDS YP_002405264.1 218697597 7145090 4455981..4456580 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; phosphatase 4456580 yihX 7145090 yihX Escherichia coli 55989 phosphatase YP_002405264.1 4455981 D 585055 CDS YP_002405265.1 218697598 7149109 4456574..4457446 1 NC_011748.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4457446 rbn 7149109 rbn Escherichia coli 55989 ribonuclease BN YP_002405265.1 4456574 D 585055 CDS YP_002405266.1 218697599 7147340 4457443..4457880 1 NC_011748.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4457880 dtd 7147340 dtd Escherichia coli 55989 D-tyrosyl-tRNA(Tyr) deacylase YP_002405266.1 4457443 D 585055 CDS YP_002405267.1 218697600 7145959 4457877..4458866 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acetyltransferase 4458866 yiiD 7145959 yiiD Escherichia coli 55989 acetyltransferase YP_002405267.1 4457877 D 585055 CDS YP_002405268.1 218697601 7149110 complement(4458930..4459913) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; lipase 4459913 7149110 EC55989_4363 Escherichia coli 55989 lipase YP_002405268.1 4458930 R 585055 CDS YP_002405269.1 218697602 7145091 4460067..4460378 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4460378 7145091 EC55989_4364 Escherichia coli 55989 hypothetical protein YP_002405269.1 4460067 D 585055 CDS YP_002405270.1 218697603 7145092 4460379..4460669 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; transcriptional regulator 4460669 7145092 EC55989_4365 Escherichia coli 55989 transcriptional regulator YP_002405270.1 4460379 D 585055 CDS YP_002405271.1 218697604 7145093 4461255..4461473 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 4461473 yiiE 7145093 yiiE Escherichia coli 55989 transcriptional regulator YP_002405271.1 4461255 D 585055 CDS YP_002405272.1 218697605 7149111 4461717..4461935 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4461935 yiiF 7149111 yiiF Escherichia coli 55989 hypothetical protein YP_002405272.1 4461717 D 585055 CDS YP_002405273.1 218697606 7149112 complement(4462265..4463194) 1 NC_011748.1 required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE 4463194 fdhE 7149112 fdhE Escherichia coli 55989 formate dehydrogenase accessory protein FdhE YP_002405273.1 4462265 R 585055 CDS YP_002405274.1 218697607 7146067 complement(4463191..4463826) 1 NC_011748.1 cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma 4463826 fdoI 7146067 fdoI Escherichia coli 55989 formate dehydrogenase-O subunit gamma YP_002405274.1 4463191 R 585055 CDS YP_002405275.1 218697608 7146074 complement(4463823..4464725) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91317715, 8522521, 9852007; Product type c : carrier; formate dehydrogenase-O, Fe-S subunit 4464725 fdoH 7146074 fdoH Escherichia coli 55989 formate dehydrogenase-O, Fe-S subunit YP_002405275.1 4463823 R 585055 CDS YP_002405276.1 218697609 7146073 complement(4464738..4467788) 1 NC_011748.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-O, large subunit 4467788 fdoG 7146073 fdoG Escherichia coli 55989 formate dehydrogenase-O, large subunit YP_002405276.1 4464738 R 585055 CDS YP_002405277.1 218697610 7146072 4467982..4468815 1 NC_011748.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4468815 fdhD 7146072 fdhD Escherichia coli 55989 formate dehydrogenase accessory protein YP_002405277.1 4467982 D 585055 CDS YP_002405278.1 218697611 7146066 4468968..4470008 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4470008 yiiG 7146066 yiiG Escherichia coli 55989 hypothetical protein YP_002405278.1 4468968 D 585055 CDS YP_002405279.1 218697612 7149113 complement(4470058..4471806) 1 NC_011748.1 repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; frv operon regulatory protein 4471806 frvR 7149113 frvR Escherichia coli 55989 frv operon regulatory protein YP_002405279.1 4470058 R 585055 CDS YP_002405280.1 218697613 7146201 complement(4471806..4472876) 1 NC_011748.1 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; fructose-specific phosphotransferase system protein FrvX 4472876 frvX 7146201 frvX Escherichia coli 55989 fructose-specific phosphotransferase system protein FrvX YP_002405280.1 4471806 R 585055 CDS YP_002405281.1 218697614 7146202 complement(4472866..4474317) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 94290319; Product type t : transporter; PTS system transporter subunits IIBC 4474317 frvB 7146202 frvB Escherichia coli 55989 PTS system transporter subunits IIBC YP_002405281.1 4472866 R 585055 CDS YP_002405282.1 218697615 7146200 complement(4474328..4474774) 1 NC_011748.1 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; fructose-like phosphotransferase system subunit EIIA 4474774 frvA 7146200 frvA Escherichia coli 55989 fructose-like phosphotransferase system subunit EIIA YP_002405282.1 4474328 R 585055 CDS YP_002405283.1 218697616 7146199 complement(4475087..4475401) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078; Product type e : enzyme; L-rhamnose mutarotase 4475401 yiiL 7146199 yiiL Escherichia coli 55989 L-rhamnose mutarotase YP_002405283.1 4475087 R 585055 CDS YP_002405284.1 218697617 7149114 complement(4475411..4476235) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90128204, 93374854, 8396120; Product type e : enzyme; rhamnulose-1-phosphate aldolase 4476235 rhaD 7149114 rhaD Escherichia coli 55989 rhamnulose-1-phosphate aldolase YP_002405284.1 4475411 R 585055 CDS YP_002405285.1 218697618 7147392 complement(4476477..4477736) 1 NC_011748.1 catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase 4477736 rhaA 7147392 rhaA Escherichia coli 55989 L-rhamnose isomerase YP_002405285.1 4476477 R 585055 CDS YP_002405286.1 218697619 7147390 complement(4477733..4479202) 1 NC_011748.1 catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase 4479202 rhaB 7147390 rhaB Escherichia coli 55989 rhamnulokinase YP_002405286.1 4477733 R 585055 CDS YP_002405287.1 218697620 7147391 4479490..4480326 1 NC_011748.1 activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4480326 rhaS 7147391 rhaS Escherichia coli 55989 transcriptional activator RhaS YP_002405287.1 4479490 D 585055 CDS YP_002405288.1 218697621 7147394 4480310..4481248 1 NC_011748.1 activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4481248 rhaR 7147394 rhaR Escherichia coli 55989 transcriptional activator RhaR YP_002405288.1 4480310 D 585055 CDS YP_002405289.1 218697622 7147393 complement(4481245..4482279) 1 NC_011748.1 transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter 4482279 rhaT 7147393 rhaT Escherichia coli 55989 rhamnose-proton symporter YP_002405289.1 4481245 R 585055 CDS YP_002405290.1 218697623 7147395 4482564..4483184 1 NC_011748.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4483184 sodA 7147395 sodA Escherichia coli 55989 superoxide dismutase YP_002405290.1 4482564 D 585055 CDS YP_002405291.1 218697624 7147671 4483402..4484376 1 NC_011748.1 transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4484376 kdgT 7147671 kdgT Escherichia coli 55989 2-keto-3-deoxygluconate permease YP_002405291.1 4483402 D 585055 CDS YP_002405292.1 218697625 7146653 4484574..4485248 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4485248 yiiM 7146653 yiiM Escherichia coli 55989 hypothetical protein YP_002405292.1 4484574 D 585055 CDS YP_002405293.1 218697626 7149115 complement(4485354..4486727) 1 NC_011748.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein 4486727 cpxA 7149115 cpxA Escherichia coli 55989 two-component sensor protein YP_002405293.1 4485354 R 585055 CDS YP_002405294.1 218697627 7145748 complement(4486724..4487422) 1 NC_011748.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR 4487422 cpxR 7145748 cpxR Escherichia coli 55989 DNA-binding transcriptional regulator CpxR YP_002405294.1 4486724 R 585055 CDS YP_002405295.1 218697628 7145750 4487572..4488072 1 NC_011748.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; repressor CpxP 4488072 cpxP 7145750 cpxP Escherichia coli 55989 repressor CpxP YP_002405295.1 4487572 D 585055 CDS YP_002405296.1 218697629 7145749 4488221..4489123 1 NC_011748.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4489123 fieF 7145749 fieF Escherichia coli 55989 ferrous iron efflux protein F YP_002405296.1 4488221 D 585055 CDS YP_002405297.1 218697630 7146108 4489304..4490266 1 NC_011748.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4490266 pfkA 7146108 pfkA Escherichia coli 55989 6-phosphofructokinase YP_002405297.1 4489304 D 585055 CDS YP_002405298.1 218697631 7147139 4490586..4491575 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91161616, 2002055, 3158524, 8774726, 9298646; Product type t : transporter; sulfate transporter subunit 4491575 sbp 7147139 sbp Escherichia coli 55989 sulfate transporter subunit YP_002405298.1 4490586 D 585055 CDS YP_002405299.1 218697632 7147611 4491682..4492437 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86008270, 2995360, 3158524; Product type e : enzyme; CDP-diacylglycerol pyrophosphatase 4492437 cdh 7147611 cdh Escherichia coli 55989 CDP-diacylglycerol pyrophosphatase YP_002405299.1 4491682 D 585055 CDS YP_002405300.1 218697633 7145684 complement(4492492..4493259) 1 NC_011748.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase 4493259 tpiA 7145684 tpiA Escherichia coli 55989 triosephosphate isomerase YP_002405300.1 4492492 R 585055 CDS YP_002405301.1 218697634 7147830 complement(4493367..4493966) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4493966 yiiQ 7147830 yiiQ Escherichia coli 55989 hypothetical protein YP_002405301.1 4493367 R 585055 CDS YP_002405302.1 218697635 7149116 4494067..4494507 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4494507 yiiR 7149116 yiiR Escherichia coli 55989 inner membrane protein YP_002405302.1 4494067 D 585055 CDS YP_002405303.1 218697636 7149117 4494719..4495018 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4495018 yiiS 7149117 yiiS Escherichia coli 55989 hypothetical protein YP_002405303.1 4494719 D 585055 CDS YP_002405304.1 218697637 7149118 4495045..4495473 1 NC_011748.1 with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4495473 yiiT 7149118 yiiT Escherichia coli 55989 universal stress protein UspD YP_002405304.1 4495045 D 585055 CDS YP_002405305.1 218697638 7149119 complement(4495478..4496224) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93194782, 94092163, 95050480, 95362685, 1400248, 2834327, 7961651, 8449868, 9149148; Product type e : enzyme; ferredoxin-NADP reductase 4496224 fpr 7149119 fpr Escherichia coli 55989 ferredoxin-NADP reductase YP_002405305.1 4495478 R 585055 CDS YP_002405306.1 218697639 7146177 complement(4496321..4497331) 1 NC_011748.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II 4497331 glpX 7146177 glpX Escherichia coli 55989 fructose 1,6-bisphosphatase II YP_002405306.1 4496321 R 585055 CDS YP_002405307.1 218697640 7146326 complement(4497467..4498975) 1 NC_011748.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase 4498975 glpK 7146326 glpK Escherichia coli 55989 glycerol kinase YP_002405307.1 4497467 R 585055 CDS YP_002405308.1 218697641 7146322 complement(4498998..4499843) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12629974, 12948772, 14646142, 15004242, 90094250, 92210584, 11039922, 11101882, 11226336, 11964478, 1372899, 2544860, 6998951; Product type t : transporter; glycerol facilitator 4499843 glpF 7146322 glpF Escherichia coli 55989 glycerol facilitator YP_002405308.1 4498998 R 585055 CDS YP_002405309.1 218697642 7146320 4500269..4500514 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4500514 yiiU 7146320 yiiU Escherichia coli 55989 hypothetical protein YP_002405309.1 4500269 D 585055 CDS YP_002405310.1 218697643 7149120 complement(4500599..4501084) 1 NC_011748.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA 4501084 rraA 7149120 rraA Escherichia coli 55989 ribonuclease activity regulator protein RraA YP_002405310.1 4500599 R 585055 CDS YP_002405311.1 218697644 7147526 complement(4501177..4502103) 1 NC_011748.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase 4502103 menA 7147526 menA Escherichia coli 55989 1,4-dihydroxy-2-naphthoate octaprenyltransferase YP_002405311.1 4501177 R 585055 CDS YP_002405312.1 218697645 7146817 complement(4502170..4503501) 1 NC_011748.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU 4503501 hslU 7146817 hslU Escherichia coli 55989 ATP-dependent protease ATP-binding subunit HslU YP_002405312.1 4502170 R 585055 CDS YP_002405313.1 218697646 7146470 complement(4503511..4504041) 1 NC_011748.1 heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit 4504041 hslV 7146470 hslV Escherichia coli 55989 ATP-dependent protease peptidase subunit YP_002405313.1 4503511 R 585055 CDS YP_002405314.1 218697647 7146471 complement(4504134..4505093) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9282742, 93285993, 8509333; Product type cp : cell process; cell division protein FtsN 4505093 ftsN 7146471 ftsN Escherichia coli 55989 cell division protein FtsN YP_002405314.1 4504134 R 585055 CDS YP_002405315.1 218697648 7146217 complement(4505185..4506210) 1 NC_011748.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR 4506210 cytR 7146217 cytR Escherichia coli 55989 DNA-binding transcriptional regulator CytR YP_002405315.1 4505185 R 585055 CDS YP_002405316.1 218697649 7145838 complement(4506366..4508564) 1 NC_011748.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA 4508564 priA 7145838 priA Escherichia coli 55989 primosome assembly protein PriA YP_002405316.1 4506366 R 585055 CDS YP_002405317.1 218697650 7147244 4508767..4508979 1 NC_011748.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4508979 rpmE 7147244 rpmE Escherichia coli 55989 50S ribosomal protein L31 YP_002405317.1 4508767 D 585055 CDS YP_002405318.1 218697651 7147490 4509139..4513323 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 2403547, 2644231, 7934896, 8387990; Product type h : extrachromosomal origin; rhsB element core protein RshB 4513323 rhsB 7147490 rhsB Escherichia coli 55989 rhsB element core protein RshB YP_002405318.1 4509139 D 585055 CDS YP_002405319.1 218697652 7147401 complement(4513617..4513931) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; iso-IS1 InsB protein, transposase 4513931 7147401 EC55989_4416 Escherichia coli 55989 iso-IS1 InsB protein, transposase YP_002405319.1 4513617 R 585055 CDS YP_002405320.1 218697653 7149122 complement(4515221..4515538) 1 NC_011748.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ 4515538 metJ 7149122 metJ Escherichia coli 55989 transcriptional repressor protein MetJ YP_002405320.1 4515221 R 585055 CDS YP_002405321.1 218697654 7146832 4515815..4516975 1 NC_011748.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4516975 metB 7146832 metB Escherichia coli 55989 cystathionine gamma-synthase YP_002405321.1 4515815 D 585055 CDS YP_002405322.1 218697655 7146825 4516978..4519410 1 NC_011748.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4519410 metL 7146825 metL Escherichia coli 55989 bifunctional aspartate kinase II/homoserine dehydrogenase II YP_002405322.1 4516978 D 585055 CDS YP_002405323.1 218697656 7146834 4519759..4520649 1 NC_011748.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4520649 metF 7146834 metF Escherichia coli 55989 5,10-methylenetetrahydrofolate reductase YP_002405323.1 4519759 D 585055 CDS YP_002405324.1 218697657 7146828 4520978..4523158 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90292022, 94209230, 3045098; Product type e : enzyme; catalase/hydroperoxidase HPI(I) 4523158 katG 7146828 katG Escherichia coli 55989 catalase/hydroperoxidase HPI(I) YP_002405324.1 4520978 D 585055 CDS YP_002405325.1 218697658 7146646 4523252..4524157 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; permease 4524157 yijE 7146646 yijE Escherichia coli 55989 permease YP_002405325.1 4523252 D 585055 CDS YP_002405326.1 218697659 7149124 complement(4524184..4524801) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4524801 yijF 7149124 yijF Escherichia coli 55989 hypothetical protein YP_002405326.1 4524184 R 585055 CDS YP_002405327.1 218697660 7149125 complement(4525076..4526179) 1 NC_011748.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase 4526179 gldA 7149125 gldA Escherichia coli 55989 glycerol dehydrogenase YP_002405327.1 4525076 R 585055 CDS YP_002405328.1 218697661 7146291 complement(4526190..4526852) 1 NC_011748.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 4526852 fsaB 7146291 fsaB Escherichia coli 55989 fructose-6-phosphate aldolase YP_002405328.1 4526190 R 585055 CDS YP_002405329.1 218697662 7146207 complement(4526864..4529365) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 95291446, 7773398; Product type t : transporter; fused PTS enzymes: Hpr component ; enzyme I component ; enzyme IIA component 4529365 ptsA 7146207 ptsA Escherichia coli 55989 fused PTS enzymes: Hpr component ; enzyme I component ; enzyme IIA component YP_002405329.1 4526864 R 585055 CDS YP_002405330.1 218697663 7147285 4529674..4530753 1 NC_011748.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; fructose-like permease EIIC subunit 2 4530753 frwC 7147285 frwC Escherichia coli 55989 fructose-like permease EIIC subunit 2 YP_002405330.1 4529674 D 585055 CDS YP_002405331.1 218697664 7146204 4530768..4531088 1 NC_011748.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; PTS system fructose-like transporter subunit EIIB 4531088 frwB 7146204 frwB Escherichia coli 55989 PTS system fructose-like transporter subunit EIIB YP_002405331.1 4530768 D 585055 CDS YP_002405332.1 218697665 7146203 4531139..4533436 1 NC_011748.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; formate acetyltransferase 2 4533436 pflD 7146203 pflD Escherichia coli 55989 formate acetyltransferase 2 YP_002405332.1 4531139 D 585055 CDS YP_002405333.1 218697666 7147144 4533402..4534280 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95291446, 14673546, 7773398; Product type e : enzyme; pyruvate formate lyase II activase 4534280 pflC 7147144 pflC Escherichia coli 55989 pyruvate formate lyase II activase YP_002405333.1 4533402 D 585055 CDS YP_002405334.1 218697667 7147143 4534282..4534623 1 NC_011748.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; fructose-like phosphotransferase EIIB subunit 3 4534623 frwD 7147143 frwD Escherichia coli 55989 fructose-like phosphotransferase EIIB subunit 3 YP_002405334.1 4534282 D 585055 CDS YP_002405335.1 218697668 7146205 complement(4534610..4535461) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 4535461 yijO 7146205 yijO Escherichia coli 55989 DNA-binding transcriptional regulator YP_002405335.1 4534610 R 585055 CDS YP_002405336.1 218697669 7149126 complement(4535676..4537409) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10456927; Product type pm : membrane component; hypothetical protein 4537409 yijP 7149126 yijP Escherichia coli 55989 hypothetical protein YP_002405336.1 4535676 R 585055 CDS YP_002405337.1 218697670 7149127 complement(4537592..4540243) 1 NC_011748.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase 4540243 ppc 7149127 ppc Escherichia coli 55989 phosphoenolpyruvate carboxylase YP_002405337.1 4537592 R 585055 CDS YP_002405338.1 218697671 7147221 complement(4540595..4541746) 1 NC_011748.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase 4541746 argE 7147221 argE Escherichia coli 55989 acetylornithine deacetylase YP_002405338.1 4540595 R 585055 CDS YP_002405339.1 218697672 7145528 4541900..4542904 1 NC_011748.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4542904 argC 7145528 argC Escherichia coli 55989 N-acetyl-gamma-glutamyl-phosphate reductase YP_002405339.1 4541900 D 585055 CDS YP_002405340.1 218697673 7145526 4542915..4543688 1 NC_011748.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4543688 argB 7145526 argB Escherichia coli 55989 acetylglutamate kinase YP_002405340.1 4542915 D 585055 CDS YP_002405341.1 218697674 7145525 4543749..4545122 1 NC_011748.1 catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4545122 argH 7145525 argH Escherichia coli 55989 argininosuccinate lyase YP_002405341.1 4543749 D 585055 CDS YP_002405342.1 218697675 7145530 4545620..4546834 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : enzyme; enolase/dehydratase 4546834 rspA 7145530 rspA Escherichia coli 55989 enolase/dehydratase YP_002405342.1 4545620 D 585055 CDS YP_002405343.1 218697676 7147538 4546901..4548184 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4548184 7147538 EC55989_4444 Escherichia coli 55989 transporter YP_002405343.1 4546901 D 585055 CDS YP_002405344.1 218697677 7147089 4548435..4549352 1 NC_011748.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4549352 oxyR 7147089 oxyR Escherichia coli 55989 DNA-binding transcriptional regulator OxyR YP_002405344.1 4548435 D 585055 CDS YP_002405345.1 218697678 7147088 complement(4549335..4550735) 1 NC_011748.1 catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase 4550735 sthA 7147088 sthA Escherichia coli 55989 soluble pyridine nucleotide transhydrogenase YP_002405345.1 4549335 R 585055 CDS YP_002405346.1 218697679 7147724 4551012..4551716 1 NC_011748.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4551716 fabR 7147724 fabR Escherichia coli 55989 DNA-binding transcriptional repressor FabR YP_002405346.1 4551012 D 585055 CDS YP_002405347.1 218697680 7146053 4551716..4552075 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 4552075 yijD 7146053 yijD Escherichia coli 55989 hypothetical protein YP_002405347.1 4551716 D 585055 CDS YP_002405348.1 218697681 7149123 complement(4552115..4553215) 1 NC_011748.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase 4553215 trmA 7149123 trmA Escherichia coli 55989 tRNA (uracil-5-)-methyltransferase YP_002405348.1 4552115 R 585055 CDS YP_002405349.1 218697682 7145314 4553584..4555428 1 NC_011748.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4555428 btuB 7145314 btuB Escherichia coli 55989 vitamin B12/cobalamin outer membrane transporter YP_002405349.1 4553584 D 585055 CDS YP_002405350.1 218697683 7145639 4555373..4556230 1 NC_011748.1 converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4556230 murI 7145639 murI Escherichia coli 55989 glutamate racemase YP_002405350.1 4555373 D 585055 CDS YP_002405351.1 218697684 7145293 4561916..4562944 1 NC_011748.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4562944 murB 7145293 murB Escherichia coli 55989 UDP-N-acetylenolpyruvoylglucosamine reductase YP_002405351.1 4561916 D 585055 CDS YP_002405352.1 218697685 7146922 4562941..4563906 1 NC_011748.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4563906 birA 7146922 birA Escherichia coli 55989 biotin--protein ligase YP_002405352.1 4562941 D 585055 CDS YP_002405353.1 218697686 7145631 complement(4563935..4564885) 1 NC_011748.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase 4564885 coaA 7145631 coaA Escherichia coli 55989 pantothenate kinase YP_002405353.1 4563935 R 585055 CDS YP_002405354.1 218697687 7145362 4565803..4566987 1 NC_011748.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4566987 tufB 7145362 tufB Escherichia coli 55989 elongation factor Tu YP_002405354.1 4565803 D 585055 CDS YP_002405355.1 218697688 7147873 4567217..4567600 1 NC_011748.1 forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4567600 secE 7147873 secE Escherichia coli 55989 preprotein translocase subunit SecE YP_002405355.1 4567217 D 585055 CDS YP_002405356.1 218697689 7147623 4567602..4568147 1 NC_011748.1 Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4568147 nusG 7147623 nusG Escherichia coli 55989 transcription antitermination protein NusG YP_002405356.1 4567602 D 585055 CDS YP_002405357.1 218697690 7147060 4568306..4568734 1 NC_011748.1 binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4568734 rplK 7147060 rplK Escherichia coli 55989 50S ribosomal protein L11 YP_002405357.1 4568306 D 585055 CDS YP_002405358.1 218697691 7147471 4568738..4569442 1 NC_011748.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4569442 rplA 7147471 rplA Escherichia coli 55989 50S ribosomal protein L1 YP_002405358.1 4568738 D 585055 CDS YP_002405359.1 218697692 7147463 4569855..4570352 1 NC_011748.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4570352 rplJ 7147463 rplJ Escherichia coli 55989 50S ribosomal protein L10 YP_002405359.1 4569855 D 585055 CDS YP_002405360.1 218697693 7147470 4570419..4570784 1 NC_011748.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4570784 rplL 7147470 rplL Escherichia coli 55989 50S ribosomal protein L7/L12 YP_002405360.1 4570419 D 585055 CDS YP_002405361.1 218697694 7147472 4571104..4575132 1 NC_011748.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4575132 rpoB 7147472 rpoB Escherichia coli 55989 DNA-directed RNA polymerase subunit beta YP_002405361.1 4571104 D 585055 CDS YP_002405362.1 218697695 7147496 4575209..4579432 1 NC_011748.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4579432 rpoC 7147496 rpoC Escherichia coli 55989 DNA-directed RNA polymerase subunit beta' YP_002405362.1 4575209 D 585055 CDS YP_002405363.1 218697696 7147497 4579645..4580184 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264341, 92021792, 2160943; Product type f : factor; heat shock protein 4580184 htrC 7147497 htrC Escherichia coli 55989 heat shock protein YP_002405363.1 4579645 D 585055 CDS YP_002405364.1 218697697 7147709 complement(4580594..4581727) 1 NC_011748.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH 4581727 thiH 7147709 thiH Escherichia coli 55989 thiamine biosynthesis protein ThiH YP_002405364.1 4580594 R 585055 CDS YP_002405365.1 218697698 7147787 complement(4581724..4582494) 1 NC_011748.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase 4582494 thiG 7147787 thiG Escherichia coli 55989 thiazole synthase YP_002405365.1 4581724 R 585055 CDS YP_002405366.1 218697699 7147786 complement(4582496..4582696) 1 NC_011748.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS 4582696 thiS 7147786 thiS Escherichia coli 55989 sulfur carrier protein ThiS YP_002405366.1 4582496 R 585055 CDS YP_002405367.1 218697700 7147793 complement(4582680..4583435) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8432721, 94089392, 98298179, 10082377, 9632726; Product type e : enzyme; thiamin (thiazole moiety) biosynthesis protein 4583435 thiF 7147793 thiF Escherichia coli 55989 thiamin (thiazole moiety) biosynthesis protein YP_002405367.1 4582680 R 585055 CDS YP_002405368.1 218697701 7147785 complement(4583428..4584063) 1 NC_011748.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase 4584063 thiE 7147785 thiE Escherichia coli 55989 thiamine-phosphate pyrophosphorylase YP_002405368.1 4583428 R 585055 CDS YP_002405369.1 218697702 7147784 complement(4584063..4585958) 1 NC_011748.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC 4585958 thiC 7147784 thiC Escherichia coli 55989 thiamine biosynthesis protein ThiC YP_002405369.1 4584063 R 585055 CDS YP_002405370.1 218697703 7145315 complement(4586191..4586667) 1 NC_011748.1 binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor 4586667 rsd 7145315 rsd Escherichia coli 55989 anti-RNA polymerase sigma 70 factor YP_002405370.1 4586191 R 585055 CDS YP_002405371.1 218697704 7147529 4586762..4587535 1 NC_011748.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4587535 nudC 7147529 nudC Escherichia coli 55989 NADH pyrophosphatase YP_002405371.1 4586762 D 585055 CDS YP_002405372.1 218697705 7147037 4587575..4588639 1 NC_011748.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4588639 hemE 7147037 hemE Escherichia coli 55989 uroporphyrinogen decarboxylase YP_002405372.1 4587575 D 585055 CDS YP_002405373.1 218697706 7146411 4588649..4589320 1 NC_011748.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4589320 nfi 7146411 nfi Escherichia coli 55989 endonuclease V YP_002405373.1 4588649 D 585055 CDS YP_002405374.1 218697707 7146985 4589363..4589953 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4589953 yjaG 7146985 yjaG Escherichia coli 55989 hypothetical protein YP_002405374.1 4589363 D 585055 CDS YP_002405375.1 218697708 7149129 4590140..4590412 1 NC_011748.1 histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4590412 hupA 7149129 hupA Escherichia coli 55989 transcriptional regulator HU subunit alpha YP_002405375.1 4590140 D 585055 CDS YP_002405376.1 218697709 7146480 4590425..4591120 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4591120 yjaH 7146480 yjaH Escherichia coli 55989 hypothetical protein YP_002405376.1 4590425 D 585055 CDS YP_002405377.1 218697710 7149130 complement(4591122..4591547) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98362023, 9694902; Product type pf : factor; zinc resistance protein 4591547 zraP 7149130 zraP Escherichia coli 55989 zinc resistance protein YP_002405377.1 4591122 R 585055 CDS YP_002405378.1 218697711 7149495 4591785..4593161 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21140164, 89327164, 92255260, 11243806, 2666400; Product type r : regulator; sensor protein ZraS 4593161 zraS 7149495 zraS Escherichia coli 55989 sensor protein ZraS YP_002405378.1 4591785 D 585055 CDS YP_002405379.1 218697712 7149497 4593158..4594483 1 NC_011748.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4594483 zraR 7149497 zraR Escherichia coli 55989 transcriptional regulatory protein ZraR YP_002405379.1 4593158 D 585055 CDS YP_002405380.1 218697713 7149496 complement(4594480..4595769) 1 NC_011748.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase 4595769 purD 7149496 purD Escherichia coli 55989 phosphoribosylamine--glycine ligase YP_002405380.1 4594480 R 585055 CDS YP_002405381.1 218697714 7147295 complement(4595781..4597370) 1 NC_011748.1 involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase 4597370 purH 7147295 purH Escherichia coli 55989 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase YP_002405381.1 4595781 R 585055 CDS YP_002405382.1 218697715 7145294 complement(4603112..4603555) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; hypothetical protein 4603555 yjaB 7145294 yjaB Escherichia coli 55989 hypothetical protein YP_002405382.1 4603112 R 585055 CDS YP_002405383.1 218697716 7149128 4603712..4604641 1 NC_011748.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4604641 metA 7149128 metA Escherichia coli 55989 homoserine O-succinyltransferase YP_002405383.1 4603712 D 585055 CDS YP_002405384.1 218697717 7146824 4604910..4606511 1 NC_011748.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 4606511 aceB 7146824 aceB Escherichia coli 55989 malate synthase YP_002405384.1 4604910 D 585055 CDS YP_002405385.1 218697718 7145433 4606541..4607845 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295197, 92112731, 92353108, 2836370, 3049537, 3060852, 3276689, 3290857, 3291954, 7826335; Product type e : enzyme; isocitrate lyase 4607845 aceA 7145433 aceA Escherichia coli 55989 isocitrate lyase YP_002405385.1 4606541 D 585055 CDS YP_002405386.1 218697719 7145432 4608126..4609862 1 NC_011748.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase protein 4609862 aceK 7145432 aceK Escherichia coli 55989 bifunctional isocitrate dehydrogenase kinase/phosphatase protein YP_002405386.1 4608126 D 585055 CDS YP_002405387.1 218697720 7145551 complement(4611722..4612546) 1 NC_011748.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; IclR family transcriptional regulator 4612546 iclR 7145551 iclR Escherichia coli 55989 IclR family transcriptional regulator YP_002405387.1 4611722 R 585055 CDS YP_002405388.1 218697721 7146538 4612746..4616429 1 NC_011748.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4616429 metH 7146538 metH Escherichia coli 55989 B12-dependent methionine synthase YP_002405388.1 4612746 D 585055 CDS YP_002405389.1 218697722 7146830 4616649..4618280 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4618280 yjbB 7146830 yjbB Escherichia coli 55989 transporter YP_002405389.1 4616649 D 585055 CDS YP_002405390.1 218697723 7149132 complement(4618371..4619060) 1 NC_011748.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E 4619060 pepE 7149132 pepE Escherichia coli 55989 peptidase E YP_002405390.1 4618371 R 585055 CDS YP_002405391.1 218697724 7147133 4619272..4620144 1 NC_011748.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4620144 yjbC 7147133 yjbC Escherichia coli 55989 23S rRNA pseudouridine synthase F YP_002405391.1 4619272 D 585055 CDS YP_002405392.1 218697725 7149133 complement(4620145..4620417) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4620417 yjbD 7149133 yjbD Escherichia coli 55989 hypothetical protein YP_002405392.1 4620145 R 585055 CDS YP_002405393.1 218697726 7149134 4620946..4622073 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4622073 7149134 EC55989_4509 Escherichia coli 55989 hypothetical protein YP_002405393.1 4620946 D 585055 CDS YP_002405394.1 218697727 7145097 4622070..4622870 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4622870 7145097 EC55989_4510 Escherichia coli 55989 hypothetical protein YP_002405394.1 4622070 D 585055 CDS YP_002405395.1 218697728 7145098 complement(4622906..4623838) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; zeta toxin; poison-antidote element 4623838 7145098 EC55989_4511 Escherichia coli 55989 zeta toxin; poison-antidote element YP_002405395.1 4622906 R 585055 CDS YP_002405396.1 218697729 7145099 complement(4623977..4625326) 1 NC_011748.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase 4625326 lysC 7145099 lysC Escherichia coli 55989 aspartate kinase YP_002405396.1 4623977 R 585055 CDS YP_002405397.1 218697730 7145316 4625851..4627500 1 NC_011748.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4627500 pgi 7145316 pgi Escherichia coli 55989 glucose-6-phosphate isomerase YP_002405397.1 4625851 D 585055 CDS YP_002405398.1 218697731 7147150 complement(4627836..4628084) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4628084 7147150 EC55989_4514 Escherichia coli 55989 hypothetical protein YP_002405398.1 4627836 R 585055 CDS YP_002405399.1 218697732 7145100 4628211..4628849 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; lipoprotein 4628849 yjbF 7145100 yjbF Escherichia coli 55989 lipoprotein YP_002405399.1 4628211 D 585055 CDS YP_002405400.1 218697733 7149135 4628846..4629583 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4629583 yjbG 7149135 yjbG Escherichia coli 55989 hypothetical protein YP_002405400.1 4628846 D 585055 CDS YP_002405401.1 218697734 7149136 4629583..4631679 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; porin 4631679 yjbH 7149136 yjbH Escherichia coli 55989 porin YP_002405401.1 4629583 D 585055 CDS YP_002405402.1 218697735 7149137 4631683..4631844 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 4631844 7149137 EC55989_4518 Escherichia coli 55989 hypothetical protein YP_002405402.1 4631683 D 585055 CDS YP_002405403.1 218697736 7145101 complement(4631726..4632004) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4632004 7145101 EC55989_4519 Escherichia coli 55989 hypothetical protein YP_002405403.1 4631726 R 585055 CDS YP_002405404.1 218697737 7145102 4632274..4632684 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10986267; Product type pm : membrane component; phosphate-starvation-inducible protein PsiE 4632684 yjbA 7145102 yjbA Escherichia coli 55989 phosphate-starvation-inducible protein PsiE YP_002405404.1 4632274 D 585055 CDS YP_002405405.1 218697738 7149131 complement(4632728..4634203) 1 NC_011748.1 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter; D-xylose transporter XylE 4634203 xylE 7149131 xylE Escherichia coli 55989 D-xylose transporter XylE YP_002405405.1 4632728 R 585055 CDS YP_002405406.1 218697739 7147997 complement(4634575..4635465) 1 NC_011748.1 with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease 4635465 malG 7147997 malG Escherichia coli 55989 maltose transporter permease YP_002405406.1 4634575 R 585055 CDS YP_002405407.1 218697740 7146770 complement(4635480..4637024) 1 NC_011748.1 with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein 4637024 malF 7146770 malF Escherichia coli 55989 maltose transporter membrane protein YP_002405407.1 4635480 R 585055 CDS YP_002405408.1 218697741 7146769 complement(4637178..4638368) 1 NC_011748.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein 4638368 malE 7146769 malE Escherichia coli 55989 maltose ABC transporter periplasmic protein YP_002405408.1 4637178 R 585055 CDS YP_002405409.1 218697742 7146768 4638733..4639848 1 NC_011748.1 with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 4639848 malK 7146768 malK Escherichia coli 55989 maltose/maltodextrin transporter ATP-binding protein YP_002405409.1 4638733 D 585055 CDS YP_002405410.1 218697743 7146772 4639920..4641260 1 NC_011748.1 porin involved in the transport of maltose and maltodextrins; maltoporin 4641260 lamB 7146772 lamB Escherichia coli 55989 maltoporin YP_002405410.1 4639920 D 585055 CDS YP_002405411.1 218697744 7146679 4641412..4642332 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87141162, 2434655, 6086106; Product type pt : transporter; maltose regulon periplasmic protein 4642332 malM 7146679 malM Escherichia coli 55989 maltose regulon periplasmic protein YP_002405411.1 4641412 D 585055 CDS YP_002405412.1 218697745 7146773 4642561..4642755 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4642755 7146773 EC55989_4529 Escherichia coli 55989 hypothetical protein YP_002405412.1 4642561 D 585055 CDS YP_002405413.1 218697746 7145103 4642813..4644141 1 NC_011748.1 in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations; hypothetical protein 4644141 yjbI 7145103 yjbI Escherichia coli 55989 hypothetical protein YP_002405413.1 4642813 D 585055 CDS YP_002405414.1 218697747 7149138 4644364..4644861 1 NC_011748.1 catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4644861 ubiC 7149138 ubiC Escherichia coli 55989 chorismate pyruvate lyase YP_002405414.1 4644364 D 585055 CDS YP_002405415.1 218697748 7147889 4644874..4645746 1 NC_011748.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4645746 ubiA 7147889 ubiA Escherichia coli 55989 4-hydroxybenzoate octaprenyltransferase YP_002405415.1 4644874 D 585055 CDS YP_002405416.1 218697749 7147887 complement(4645901..4648324) 1 NC_011748.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase 4648324 plsB 7147887 plsB Escherichia coli 55989 glycerol-3-phosphate acyltransferase YP_002405416.1 4645901 R 585055 CDS YP_002405417.1 218697750 7147195 4648495..4648863 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10220339, 6257698, 86278195, 88111690, 2984194, 6309817, 8071224; Product type e : enzyme; diacylglycerol kinase 4648863 dgkA 7147195 dgkA Escherichia coli 55989 diacylglycerol kinase YP_002405417.1 4648495 D 585055 CDS YP_002405418.1 218697751 7145894 4648973..4649581 1 NC_011748.1 Represses a number of genes involved in the response to DNA damage; LexA repressor 4649581 lexA 7145894 lexA Escherichia coli 55989 LexA repressor YP_002405418.1 4648973 D 585055 CDS YP_002405419.1 218697752 7146696 4649600..4651000 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165788; Product type cp : cell process; DNA-damage-inducible SOS response protein 4651000 dinF 7146696 dinF Escherichia coli 55989 DNA-damage-inducible SOS response protein YP_002405419.1 4649600 D 585055 CDS YP_002405420.1 218697753 7145916 4651096..4651305 1 NC_011748.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; stress-response protein 4651305 yjbJ 7145916 yjbJ Escherichia coli 55989 stress-response protein YP_002405420.1 4651096 D 585055 CDS YP_002405421.1 218697754 7149139 complement(4651347..4651862) 1 NC_011748.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor 4651862 zur 7149139 zur Escherichia coli 55989 zinc uptake transcriptional repressor YP_002405421.1 4651347 R 585055 CDS YP_002405422.1 218697755 7149499 4652180..4652434 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4652434 yjbL 7149499 yjbL Escherichia coli 55989 hypothetical protein YP_002405422.1 4652180 D 585055 CDS YP_002405423.1 218697756 7149140 4652425..4653171 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4653171 yjbM 7149140 yjbM Escherichia coli 55989 hypothetical protein YP_002405423.1 4652425 D 585055 CDS YP_002405424.1 218697757 7149141 4653535..4654572 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase A 4654572 yjbN 7149141 yjbN Escherichia coli 55989 tRNA-dihydrouridine synthase A YP_002405424.1 4653535 D 585055 CDS YP_002405425.1 218697758 7149142 4654496..4654948 1 NC_011748.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4654948 pspG 7149142 pspG Escherichia coli 55989 phage shock protein G YP_002405425.1 4654496 D 585055 CDS YP_002405426.1 218697759 7149143 complement(4655114..4656097) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94089392, 7602590; Product type e : enzyme; quinone oxidoreductase 4656097 qor 7149143 qor Escherichia coli 55989 quinone oxidoreductase YP_002405426.1 4655114 R 585055 CDS YP_002405427.1 218697760 7147328 4656180..4657595 1 NC_011748.1 unwinds double stranded DNA; replicative DNA helicase 4657595 dnaB 7147328 dnaB Escherichia coli 55989 replicative DNA helicase YP_002405427.1 4656180 D 585055 CDS YP_002405428.1 218697761 7145933 4657648..4658727 1 NC_011748.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4658727 alr 7145933 alr Escherichia coli 55989 alanine racemase YP_002405428.1 4657648 D 585055 CDS YP_002405429.1 218697762 7145488 4658980..4660173 1 NC_011748.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4660173 tyrB 7145488 tyrB Escherichia coli 55989 aromatic amino acid aminotransferase YP_002405429.1 4658980 D 585055 CDS YP_002405430.1 218697763 7147882 complement(4660395..4660937) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4660937 7147882 EC55989_4548 Escherichia coli 55989 hypothetical protein YP_002405430.1 4660395 R 585055 CDS YP_002405431.1 218697764 7145104 4661300..4662013 1 NC_011748.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 4662013 aphA 7145104 aphA Escherichia coli 55989 acid phosphatase/phosphotransferase YP_002405431.1 4661300 D 585055 CDS YP_002405432.1 218697765 7145507 4662124..4662540 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11972052; hypothetical protein 4662540 yjbQ 7145507 yjbQ Escherichia coli 55989 hypothetical protein YP_002405432.1 4662124 D 585055 CDS YP_002405433.1 218697766 7149144 4662544..4662900 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4662900 yjbR 7149144 yjbR Escherichia coli 55989 hypothetical protein YP_002405433.1 4662544 D 585055 CDS YP_002405434.1 218697767 7149145 complement(4662935..4665757) 1 NC_011748.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A 4665757 uvrA 7149145 uvrA Escherichia coli 55989 excinuclease ABC subunit A YP_002405434.1 4662935 R 585055 CDS YP_002405435.1 218697768 7147933 4666011..4666547 1 NC_011748.1 binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4666547 ssb 7147933 ssb Escherichia coli 55989 single-stranded DNA-binding protein YP_002405435.1 4666011 D 585055 CDS YP_002405436.1 218697769 7147710 complement(4666646..4666927) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4666927 yjcB 7147710 yjcB Escherichia coli 55989 inner membrane protein YP_002405436.1 4666646 R 585055 CDS YP_002405437.1 218697770 7149146 4667357..4668943 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; signal transduction protein (EAL domain containing protein) 4668943 yjcC 7149146 yjcC Escherichia coli 55989 signal transduction protein (EAL domain containing protein) YP_002405437.1 4667357 D 585055 CDS YP_002405438.1 218697771 7149147 complement(4668946..4669269) 1 NC_011748.1 regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS 4669269 soxS 7149147 soxS Escherichia coli 55989 DNA-binding transcriptional regulator SoxS YP_002405438.1 4668946 R 585055 CDS YP_002405439.1 218697772 7147680 4669355..4669819 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91210176, 91360349, 94139656, 9564045, 10207625, 12670967, 1653416, 1708380, 7673113, 8065907, 8306957, 8631739, 8969171, 9019397, 9092651, 9204707; Product type r : regulator; DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing 4669819 soxR 7147680 soxR Escherichia coli 55989 DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing YP_002405439.1 4669355 D 585055 CDS YP_002405440.1 218697773 7147594 4670365..4671714 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; permease 4671714 yjcD 7147594 yjcD Escherichia coli 55989 permease YP_002405440.1 4670365 D 585055 CDS YP_002405441.1 218697774 7149148 4671865..4673514 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21557160, 11479290; Product type pt : transporter; cation/proton antiporter 4673514 yjcE 7149148 yjcE Escherichia coli 55989 cation/proton antiporter YP_002405441.1 4671865 D 585055 CDS YP_002405442.1 218697775 7149149 complement(4673668..4674960) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4674960 yjcF 7149149 yjcF Escherichia coli 55989 hypothetical protein YP_002405442.1 4673668 R 585055 CDS YP_002405443.1 218697776 7149150 complement(4675138..4676787) 1 NC_011748.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease 4676787 actP 7149150 actP Escherichia coli 55989 acetate permease YP_002405443.1 4675138 R 585055 CDS YP_002405444.1 218697777 7145451 complement(4676784..4677098) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14563880; Product type pm : membrane component; hypothetical protein 4677098 yjcH 7145451 yjcH Escherichia coli 55989 hypothetical protein YP_002405444.1 4676784 R 585055 CDS YP_002405445.1 218697778 7149151 complement(4677298..4679256) 1 NC_011748.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase 4679256 acs 7149151 acs Escherichia coli 55989 acetyl-CoA synthetase YP_002405445.1 4677298 R 585055 CDS YP_002405446.1 218697779 7145450 4679648..4681084 1 NC_011748.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4681084 nrfA 7145450 nrfA Escherichia coli 55989 cytochrome c552 YP_002405446.1 4679648 D 585055 CDS YP_002405447.1 218697780 7147027 4681129..4681695 1 NC_011748.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4681695 nrfB 7147027 nrfB Escherichia coli 55989 cytochrome c nitrite reductase pentaheme subunit YP_002405447.1 4681129 D 585055 CDS YP_002405448.1 218697781 7147028 4681692..4682363 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94335626, 8057835; Product type c : carrier; formate-dependent nitrite reductase, 4Fe4S subunit 4682363 nrfC 7147028 nrfC Escherichia coli 55989 formate-dependent nitrite reductase, 4Fe4S subunit YP_002405448.1 4681692 D 585055 CDS YP_002405449.1 218697782 7147029 4682360..4683316 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 8057835; Product type e : enzyme; formate-dependent nitrite reductase, membrane subunit 4683316 nrfD 7147029 nrfD Escherichia coli 55989 formate-dependent nitrite reductase, membrane subunit YP_002405449.1 4682360 D 585055 CDS YP_002405450.1 218697783 7147030 4683396..4685054 1 NC_011748.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4685054 nrfE 7147030 nrfE Escherichia coli 55989 heme lyase subunit NrfE YP_002405450.1 4683396 D 585055 CDS YP_002405451.1 218697784 7147031 4685047..4685430 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfF 4685430 nrfF 7147031 nrfF Escherichia coli 55989 formate-dependent nitrite reductase complex subunit NrfF YP_002405451.1 4685047 D 585055 CDS YP_002405452.1 218697785 7147032 4685427..4686023 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfG 4686023 nrfG 7147032 nrfG Escherichia coli 55989 formate-dependent nitrite reductase complex subunit NrfG YP_002405452.1 4685427 D 585055 CDS YP_002405453.1 218697786 7147033 4686365..4687678 1 NC_011748.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4687678 gltP 7147033 gltP Escherichia coli 55989 glutamate/aspartate:proton symporter YP_002405453.1 4686365 D 585055 CDS YP_002405454.1 218697787 7146334 complement(4687756..4688445) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4688445 yjcO 7146334 yjcO Escherichia coli 55989 hypothetical protein YP_002405454.1 4687756 R 585055 CDS YP_002405455.1 218697788 7149152 complement(4688539..4690686) 1 NC_011748.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-H, selenopolypeptide subunit 4690686 fdhF 7149152 fdhF Escherichia coli 55989 formate dehydrogenase-H, selenopolypeptide subunit YP_002405455.1 4688539 R 585055 CDS YP_002405456.1 218697789 7146068 complement(4690884..4692350) 1 NC_011748.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; outer membrane efflux protein MdtP 4692350 yjcP 7146068 yjcP Escherichia coli 55989 outer membrane efflux protein MdtP YP_002405456.1 4690884 R 585055 CDS YP_002405457.1 218697790 7149153 complement(4692347..4694398) 1 NC_011748.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO 4694398 yjcQ 7149153 yjcQ Escherichia coli 55989 multidrug efflux system protein MdtO YP_002405457.1 4692347 R 585055 CDS YP_002405458.1 218697791 7149154 complement(4694398..4695429) 1 NC_011748.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN 4695429 yjcR 7149154 yjcR Escherichia coli 55989 multidrug resistance protein MdtN YP_002405458.1 4694398 R 585055 CDS YP_002405459.1 218697792 7149155 complement(4695932..4697917) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1587481; Product type pe : enzyme; alkyl sulfatase 4697917 yjcS 7149155 yjcS Escherichia coli 55989 alkyl sulfatase YP_002405459.1 4695932 R 585055 CDS YP_002405460.1 218697793 7149156 4698170..4698487 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; ribose-5-phosphate isomerase B (rpiB-like) 4698487 7149156 EC55989_4580 Escherichia coli 55989 ribose-5-phosphate isomerase B (rpiB-like) YP_002405460.1 4698170 D 585055 CDS YP_002405461.1 218697794 7145105 4698556..4698885 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4698885 yjdP 7145105 yjdP Escherichia coli 55989 hypothetical protein YP_002405461.1 4698556 D 585055 CDS YP_002405462.1 218697795 7149166 complement(4699032..4699790) 1 NC_011748.1 required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein 4699790 phnP 7149166 phnP Escherichia coli 55989 carbon-phosphorus lyase complex accessory protein YP_002405462.1 4699032 R 585055 CDS YP_002405463.1 218697796 7147177 complement(4699792..4700226) 1 NC_011748.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase 4700226 phnO 7147177 phnO Escherichia coli 55989 aminoalkylphosphonic acid N-acetyltransferase YP_002405463.1 4699792 R 585055 CDS YP_002405464.1 218697797 7147176 complement(4700213..4700770) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700258, 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; ribose 1,5-bisphosphokinase 4700770 phnN 7147176 phnN Escherichia coli 55989 ribose 1,5-bisphosphokinase YP_002405464.1 4700213 R 585055 CDS YP_002405465.1 218697798 7147175 complement(4700770..4701906) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4701906 phnM 7147175 phnM Escherichia coli 55989 carbon-phosphorus lyase complex subunit YP_002405465.1 4700770 R 585055 CDS YP_002405466.1 218697799 7147174 complement(4701903..4702583) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4702583 phnL 7147174 phnL Escherichia coli 55989 carbon-phosphorus lyase complex subunit YP_002405466.1 4701903 R 585055 CDS YP_002405467.1 218697800 7147173 complement(4702760..4703518) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; phosphonate C-P lyase system protein PhnK 4703518 phnK 7147173 phnK Escherichia coli 55989 phosphonate C-P lyase system protein PhnK YP_002405467.1 4702760 R 585055 CDS YP_002405468.1 218697801 7147172 complement(4703515..4704360) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4704360 phnJ 7147172 phnJ Escherichia coli 55989 carbon-phosphorus lyase complex subunit YP_002405468.1 4703515 R 585055 CDS YP_002405469.1 218697802 7147171 complement(4704353..4705417) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4705417 phnI 7147171 phnI Escherichia coli 55989 carbon-phosphorus lyase complex subunit YP_002405469.1 4704353 R 585055 CDS YP_002405470.1 218697803 7147170 complement(4705417..4706001) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4706001 phnH 7147170 phnH Escherichia coli 55989 carbon-phosphorus lyase complex subunit YP_002405470.1 4705417 R 585055 CDS YP_002405471.1 218697804 7147169 complement(4705998..4706450) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit 4706450 phnG 7147169 phnG Escherichia coli 55989 carbon-phosphorus lyase complex subunit YP_002405471.1 4705998 R 585055 CDS YP_002405472.1 218697805 7147168 complement(4706451..4707176) 1 NC_011748.1 may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF 4707176 phnF 7147168 phnF Escherichia coli 55989 phosphonate metabolism transcriptional regulator PhnF YP_002405472.1 4706451 R 585055 CDS YP_002405473.1 218697806 7147167 complement(4707197..4708039) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type t : transporter; phosphonates transport system, permease protein 4708039 phnE 7147167 phnE Escherichia coli 55989 phosphonates transport system, permease protein YP_002405473.1 4707197 R 585055 CDS YP_002405474.1 218697807 7147166 complement(4708082..4709098) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester transporter subunit ; periplasmic binding component of ABC superfamily 4709098 phnD 7147166 phnD Escherichia coli 55989 phosphonate/organophosphate ester transporter subunit ; periplasmic binding component of ABC superfamily YP_002405474.1 4708082 R 585055 CDS YP_002405475.1 218697808 7147165 complement(4709123..4709911) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester transporter subunit 4709911 phnC 7147165 phnC Escherichia coli 55989 phosphonate/organophosphate ester transporter subunit YP_002405475.1 4709123 R 585055 CDS YP_002405476.1 218697809 7147164 complement(4710044..4710487) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93328121, 9650256, 2155230; hypothetical protein 4710487 phnB 7147164 phnB Escherichia coli 55989 hypothetical protein YP_002405476.1 4710044 R 585055 CDS YP_002405477.1 218697810 7147163 complement(4710647..4711129) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9650256, 2155230; Product type pt : transporter; alkylphosphonate uptake protein in phosphonate metabolism 4711129 7147163 EC55989_4598 Escherichia coli 55989 alkylphosphonate uptake protein in phosphonate metabolism YP_002405477.1 4710647 R 585055 CDS YP_002405478.1 218697811 7145106 4711384..4713612 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4713612 yjdA 7145106 yjdA Escherichia coli 55989 hypothetical protein YP_002405478.1 4711384 D 585055 CDS YP_002405479.1 218697812 7149158 4713609..4714487 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4714487 yjcZ 7149158 yjcZ Escherichia coli 55989 hypothetical protein YP_002405479.1 4713609 D 585055 CDS YP_002405480.1 218697813 7149157 4714751..4716253 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10049386, 12525168, 92165733, 93132799, 9871325, 99376621, 8421314; Product type t : transporter; proline/glycine betaine transporter 4716253 proP 7149157 proP Escherichia coli 55989 proline/glycine betaine transporter YP_002405480.1 4714751 D 585055 CDS YP_002405481.1 218697814 7147255 complement(4716430..4717521) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; sensor protein BasS/PmrB 4717521 basS 7147255 basS Escherichia coli 55989 sensor protein BasS/PmrB YP_002405481.1 4716430 R 585055 CDS YP_002405482.1 218697815 7145598 complement(4717531..4718199) 1 NC_011748.1 response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR 4718199 basR 7145598 basR Escherichia coli 55989 DNA-binding transcriptional regulator BasR YP_002405482.1 4717531 R 585055 CDS YP_002405483.1 218697816 7145597 complement(4718196..4719839) 1 NC_011748.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; cell division protein 4719839 eptA 7145597 eptA Escherichia coli 55989 cell division protein YP_002405483.1 4718196 R 585055 CDS YP_002405484.1 218697817 7146018 complement(4719943..4721280) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12867448; Product type t : transporter; arginine:agmatin antiporter 4721280 adiC 7146018 adiC Escherichia coli 55989 arginine:agmatin antiporter YP_002405484.1 4719943 R 585055 CDS YP_002405485.1 218697818 7145458 complement(4721417..4722178) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : c; Product type r : regulator; DNA-binding transcriptional activator 4722178 adiY 7145458 adiY Escherichia coli 55989 DNA-binding transcriptional activator YP_002405485.1 4721417 R 585055 CDS YP_002405486.1 218697819 7145459 complement(4722503..4724773) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93186686, 2830169, 4204273, 8383109; Product type e : enzyme; biodegradative arginine decarboxylase 4724773 adiA 7145459 adiA Escherichia coli 55989 biodegradative arginine decarboxylase YP_002405486.1 4722503 R 585055 CDS YP_002405487.1 218697820 7145457 complement(4724969..4725877) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90060832, 9108148, 1445207, 2684786, 2830169; Product type r : regulator; DNA-binding transcriptional regulator MelR 4725877 melR 7145457 melR Escherichia coli 55989 DNA-binding transcriptional regulator MelR YP_002405487.1 4724969 R 585055 CDS YP_002405488.1 218697821 7146816 4726160..4727515 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87174747, 88162811, 90248411, 2831880, 3031590, 6329200; Product type e : enzyme; alpha-galactosidase 4727515 melA 7146816 melA Escherichia coli 55989 alpha-galactosidase YP_002405488.1 4726160 D 585055 CDS YP_002405489.1 218697822 7146814 4727630..4729039 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14757226, 90241878, 92297631, 93155159, 1730719, 1872836, 6323466, 8672452; Product type t : transporter; melibiose:sodium symporter 4729039 melB 7146814 melB Escherichia coli 55989 melibiose:sodium symporter YP_002405489.1 4727630 D 585055 CDS YP_002405490.1 218697823 7146815 complement(4729178..4729807) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 4729807 yjdF 7146815 yjdF Escherichia coli 55989 hypothetical protein YP_002405490.1 4729178 R 585055 CDS YP_002405491.1 218697824 7149160 complement(4729930..4731576) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86142617, 88193096, 89255123, 2656658; Product type e : enzyme; anaerobic class I fumarate hydratase 4731576 fumB 7149160 fumB Escherichia coli 55989 anaerobic class I fumarate hydratase YP_002405491.1 4729930 R 585055 CDS YP_002405492.1 218697825 7146231 complement(4731654..4732994) 1 NC_011748.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter 4732994 dcuB 7146231 dcuB Escherichia coli 55989 anaerobic C4-dicarboxylate transporter YP_002405492.1 4731654 R 585055 CDS YP_002405493.1 218697826 7145861 complement(4733565..4734284) 1 NC_011748.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR 4734284 dcuR 7145861 dcuR Escherichia coli 55989 DNA-binding transcriptional activator DcuR YP_002405493.1 4733565 R 585055 CDS YP_002405494.1 218697827 7145864 complement(4734281..4735912) 1 NC_011748.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS 4735912 dcuS 7145864 dcuS Escherichia coli 55989 sensory histidine kinase DcuS YP_002405494.1 4734281 R 585055 CDS YP_002405495.1 218697828 7145865 4736093..4736323 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4736323 yjdI 7145865 yjdI Escherichia coli 55989 hypothetical protein YP_002405495.1 4736093 D 585055 CDS YP_002405496.1 218697829 7149161 4736335..4736607 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acyltransferase with acyl-CoA N-acyltransferase domain 4736607 yjdJ 7149161 yjdJ Escherichia coli 55989 acyltransferase with acyl-CoA N-acyltransferase domain YP_002405496.1 4736335 D 585055 CDS YP_002405497.1 218697830 7149162 4736834..4737130 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4737130 yjdK 7149162 yjdK Escherichia coli 55989 hypothetical protein YP_002405497.1 4736834 D 585055 CDS YP_002405498.1 218697831 7149163 4737158..4737331 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4737331 yjdO 7149163 yjdO Escherichia coli 55989 hypothetical protein YP_002405498.1 4737158 D 585055 CDS YP_002405499.1 218697832 7149165 complement(4737450..4738967) 1 NC_011748.1 class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase 4738967 lysU 7149165 lysU Escherichia coli 55989 lysyl-tRNA synthetase YP_002405499.1 4737450 R 585055 CDS YP_002405500.1 218697833 7146760 complement(4739204..4740661) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4740661 yjdL 7146760 yjdL Escherichia coli 55989 transporter YP_002405500.1 4739204 R 585055 CDS YP_002405501.1 218697834 7149164 complement(4740720..4742867) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105022, 92210511, 1370290, 1556085, 4204273; Product type e : enzyme; lysine decarboxylase 1 4742867 cadA 7149164 cadA Escherichia coli 55989 lysine decarboxylase 1 YP_002405501.1 4740720 R 585055 CDS YP_002405502.1 218697835 7145653 complement(4742947..4744281) 1 NC_011748.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter 4744281 cadB 7145653 cadB Escherichia coli 55989 lysine/cadaverine antiporter YP_002405502.1 4742947 R 585055 CDS YP_002405503.1 218697836 7145654 complement(4744647..4746185) 1 NC_011748.1 regulates the cadBA operon; DNA-binding transcriptional activator CadC 4746185 cadC 7145654 cadC Escherichia coli 55989 DNA-binding transcriptional activator CadC YP_002405503.1 4744647 R 585055 CDS YP_002405504.1 218697837 7145655 4746472..4746690 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4746690 7145655 EC55989_4627 Escherichia coli 55989 hypothetical protein YP_002405504.1 4746472 D 585055 CDS YP_002405505.1 218697838 7145107 complement(4746934..4747776) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9987116; hypothetical protein 4747776 7145107 EC55989_4628 Escherichia coli 55989 hypothetical protein YP_002405505.1 4746934 R 585055 CDS YP_002405506.1 218697839 7145108 complement(4747861..4748295) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4748295 7145108 EC55989_4629 Escherichia coli 55989 hypothetical protein YP_002405506.1 4747861 R 585055 CDS YP_002405507.1 218697840 7145109 complement(4748078..4748566) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4748566 yeeW 7145109 yeeW Escherichia coli 55989 hypothetical protein YP_002405507.1 4748078 R 585055 CDS YP_002405508.1 218697841 7148621 complement(4748563..4749045) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type f : factor; toxin of the YeeV-YeeU toxin-antitoxin system 4749045 yeeV 7148621 yeeV Escherichia coli 55989 toxin of the YeeV-YeeU toxin-antitoxin system YP_002405508.1 4748563 R 585055 CDS YP_002405509.1 218697842 7148618 complement(4748987..4749364) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; antitoxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 4749364 yeeU 7148618 yeeU Escherichia coli 55989 antitoxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage YP_002405509.1 4748987 R 585055 CDS YP_002405510.1 218697843 7148614 complement(4749444..4749665) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; CP4-44 prophage 4749665 yeeT 7148614 yeeT Escherichia coli 55989 CP4-44 prophage YP_002405510.1 4749444 R 585055 CDS YP_002405511.1 218697844 7148610 complement(4749752..4750198) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : factor; DNA repair protein; CP4-44 prophage 4750198 yeeS 7148610 yeeS Escherichia coli 55989 DNA repair protein; CP4-44 prophage YP_002405511.1 4749752 R 585055 CDS YP_002405512.1 218697845 7148606 complement(4750244..4751098) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; antirestriction protein 4751098 7148606 EC55989_4636 Escherichia coli 55989 antirestriction protein YP_002405512.1 4750244 R 585055 CDS YP_002405513.1 218697846 7145110 4751241..4751567 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 4751567 7145110 EC55989_4637 Escherichia coli 55989 transposase ORF A, IS629 YP_002405513.1 4751241 D 585055 CDS YP_002405514.1 218697847 7145111 4751564..4752046 1 NC_011748.1 Evidence 7 : Gene remnant; Product type pe : enzyme; transposase ORF B (fragment), IS629 4752046 7145111 EC55989_4638 Escherichia coli 55989 transposase ORF B (fragment), IS629 YP_002405514.1 4751564 D 585055 CDS YP_002405515.1 218697848 7145112 4752638..4754161 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; reverse transcriptase-like protein from prophage or plasmid 4754161 7145112 EC55989_4639 Escherichia coli 55989 reverse transcriptase-like protein from prophage or plasmid YP_002405515.1 4752638 D 585055 CDS YP_002405516.1 218697849 7145114 complement(4755126..4757405) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4313071, 6456229, 7044820, 7042696, 6749806; Product type rc : receptor; Ferric aerobactin receptor precursor 4757405 iutA 7145114 iutA Escherichia coli 55989 Ferric aerobactin receptor precursor YP_002405516.1 4755126 R 585055 CDS YP_002405517.1 218697850 7146641 complement(4757327..4758664) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3275632, 10064136; Product type e : enzyme; L-lysine 6-monooxygenase (Lysine N(6)-hydroxylase) 4758664 iucD 7146641 iucD Escherichia coli 55989 L-lysine 6-monooxygenase (Lysine N(6)-hydroxylase) YP_002405517.1 4757327 R 585055 CDS YP_002405518.1 218697851 7146640 complement(4758661..4760403) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; Aerobactin siderophore biosynthesis protein 4760403 iucC 7146640 iucC Escherichia coli 55989 Aerobactin siderophore biosynthesis protein YP_002405518.1 4758661 R 585055 CDS YP_002405519.1 218697852 7146639 complement(4760403..4761350) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; aerobactin siderophore biosynthesis protein, N(6)-hydroxylysine acetylase 4761350 iucB 7146639 iucB Escherichia coli 55989 aerobactin siderophore biosynthesis protein, N(6)-hydroxylysine acetylase YP_002405519.1 4760403 R 585055 CDS YP_002405520.1 218697853 7146638 complement(4761351..4763138) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; aerobactin siderophore biosynthesis protein 4763138 iucA 7146638 iucA Escherichia coli 55989 aerobactin siderophore biosynthesis protein YP_002405520.1 4761351 R 585055 CDS YP_002405521.1 218697854 7146637 4763211..4764404 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411725; Product type pt : transporter; membrane transport protein, major facilitator superfamily 4764404 shiF 7146637 shiF Escherichia coli 55989 membrane transport protein, major facilitator superfamily YP_002405521.1 4763211 D 585055 CDS YP_002405522.1 218697855 7147654 complement(4764354..4765280) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4765280 7147654 EC55989_4647 Escherichia coli 55989 hypothetical protein YP_002405522.1 4764354 R 585055 CDS YP_002405523.1 218697856 7145115 4765587..4765784 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4765784 7145115 EC55989_4648 Escherichia coli 55989 hypothetical protein YP_002405523.1 4765587 D 585055 CDS YP_002405524.1 218697857 7145116 complement(4765771..4765956) 1 NC_011748.1 Evidence 7 : Gene remnant; Product type pe : enzyme; Transposase ORF D (fragment), ISEc8 4765956 7145116 EC55989_4649 Escherichia coli 55989 Transposase ORF D (fragment), ISEc8 YP_002405524.1 4765771 R 585055 CDS YP_002405525.1 218697858 7145117 4766020..4767153 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase, IS110 family 4767153 7145117 EC55989_4650 Escherichia coli 55989 transposase, IS110 family YP_002405525.1 4766020 D 585055 CDS YP_002405526.1 218697859 7145296 complement(4767765..4769288) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; reverse transcriptase-like protein from prophage or plasmid 4769288 7145296 EC55989_4652 Escherichia coli 55989 reverse transcriptase-like protein from prophage or plasmid YP_002405526.1 4767765 R 585055 CDS YP_002405527.1 218697860 7145120 complement(4769880..4770362) 1 NC_011748.1 Evidence 7 : Gene remnant; Product type pe : enzyme; transposase ORF B (fragment), IS629 4770362 7145120 EC55989_4653 Escherichia coli 55989 transposase ORF B (fragment), IS629 YP_002405527.1 4769880 R 585055 CDS YP_002405528.1 218697861 7145121 complement(4770359..4770685) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 4770685 7145121 EC55989_4654 Escherichia coli 55989 transposase ORF A, IS629 YP_002405528.1 4770359 R 585055 CDS YP_002405529.1 218697862 7145123 complement(4771263..4772387) 1 NC_011748.1 transposase 4772387 7145123 EC55989_4656 Escherichia coli 55989 transposase YP_002405529.1 4771263 R 585055 CDS YP_002405530.1 218697863 7145124 complement(4772454..4772615) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4772615 7145124 EC55989_4657 Escherichia coli 55989 hypothetical protein YP_002405530.1 4772454 R 585055 CDS YP_002405531.1 218697864 7145126 4773180..4773398 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4773398 7145126 EC55989_4659 Escherichia coli 55989 hypothetical protein YP_002405531.1 4773180 D 585055 CDS YP_002405532.1 218697865 7145127 complement(4773549..4777667) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; Serine protease pic precursor (ShMu) 4777667 7145127 EC55989_4660 Escherichia coli 55989 Serine protease pic precursor (ShMu) YP_002405532.1 4773549 R 585055 CDS YP_002405533.1 218697866 7145297 complement(4778395..4779918) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; reverse transcriptase-like protein from prophage or plasmid 4779918 7145297 EC55989_4662 Escherichia coli 55989 reverse transcriptase-like protein from prophage or plasmid YP_002405533.1 4778395 R 585055 CDS YP_002405534.1 218697867 7145130 complement(4780510..4780992) 1 NC_011748.1 Evidence 7 : Gene remnant; Product type pe : enzyme; transposase ORF B (fragment), IS629 4780992 7145130 EC55989_4663 Escherichia coli 55989 transposase ORF B (fragment), IS629 YP_002405534.1 4780510 R 585055 CDS YP_002405535.1 218697868 7145131 complement(4780989..4781315) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 4781315 7145131 EC55989_4664 Escherichia coli 55989 transposase ORF A, IS629 YP_002405535.1 4780989 R 585055 CDS YP_002405536.1 218697869 7145132 complement(4781960..4782124) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4782124 7145132 EC55989_4665 Escherichia coli 55989 hypothetical protein YP_002405536.1 4781960 R 585055 CDS YP_002405537.1 218697870 7145136 4784434..4786524 1 NC_011748.1 IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor; bifunctional enterobactin receptor/adhesin protein 4786524 7145136 EC55989_4669 Escherichia coli 55989 bifunctional enterobactin receptor/adhesin protein YP_002405537.1 4784434 D 585055 CDS YP_002405538.1 218697871 7145137 4786758..4786982 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4786982 7145137 EC55989_4670 Escherichia coli 55989 hypothetical protein YP_002405538.1 4786758 D 585055 CDS YP_002405539.1 218697872 7145138 complement(4787129..4788742) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; transposase ORF1, IS66 family 4788742 7145138 EC55989_4671 Escherichia coli 55989 transposase ORF1, IS66 family YP_002405539.1 4787129 R 585055 CDS YP_002405540.1 218697873 7145139 4788948..4789274 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 4789274 7145139 EC55989_4672 Escherichia coli 55989 transposase ORF A, IS629 YP_002405540.1 4788948 D 585055 CDS YP_002405541.1 218697874 7145140 4789271..4789753 1 NC_011748.1 Evidence 7 : Gene remnant; Product type pe : enzyme; transposase ORF B (fragment), IS629 4789753 7145140 EC55989_4673 Escherichia coli 55989 transposase ORF B (fragment), IS629 YP_002405541.1 4789271 D 585055 CDS YP_002405542.1 218697875 7145141 4790345..4791868 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; reverse transcriptase-like protein from prophage or plasmid 4791868 7145141 EC55989_4674 Escherichia coli 55989 reverse transcriptase-like protein from prophage or plasmid YP_002405542.1 4790345 D 585055 CDS YP_002405543.1 218697876 7145144 complement(4792703..4793128) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; transposase OrfA from plasmid origin 4793128 7145144 EC55989_4677 Escherichia coli 55989 transposase OrfA from plasmid origin YP_002405543.1 4792703 R 585055 CDS YP_002405544.1 218697877 7145145 complement(4793356..4794270) 1 NC_011748.1 Evidence 7 : Gene remnant; transposase (fragment) 4794270 7145145 EC55989_4678 Escherichia coli 55989 transposase (fragment) YP_002405544.1 4793356 R 585055 CDS YP_002405545.1 218697878 7145146 complement(4794357..4795040) 1 NC_011748.1 Evidence 7 : Gene remnant; transposase (fragment) 4795040 7145146 EC55989_4679 Escherichia coli 55989 transposase (fragment) YP_002405545.1 4794357 R 585055 CDS YP_002405546.1 218697879 7145148 complement(4795739..4796488) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4796488 7145148 EC55989_4681 Escherichia coli 55989 hypothetical protein YP_002405546.1 4795739 R 585055 CDS YP_002405547.1 218697880 7145149 complement(4796367..4800224) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; Serine protease pet precursor (Plasmid-encoded toxin pet) 4800224 7145149 EC55989_4682 Escherichia coli 55989 Serine protease pet precursor (Plasmid-encoded toxin pet) YP_002405547.1 4796367 R 585055 CDS YP_002405548.1 218697881 7145152 complement(4802695..4806210) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; superfamily I DNA helicase 4806210 7145152 EC55989_4686 Escherichia coli 55989 superfamily I DNA helicase YP_002405548.1 4802695 R 585055 CDS YP_002405549.1 218697882 7145153 4806299..4806562 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4806562 7145153 EC55989_4687 Escherichia coli 55989 hypothetical protein YP_002405549.1 4806299 D 585055 CDS YP_002405550.1 218697883 7145154 complement(4806663..4807925) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Prophage integrase 4807925 int 7145154 int Escherichia coli 55989 Prophage integrase YP_002405550.1 4806663 R 585055 CDS YP_002405551.1 218697884 7146606 complement(4807989..4808237) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4808237 7146606 EC55989_4689 Escherichia coli 55989 hypothetical protein YP_002405551.1 4807989 R 585055 CDS YP_002405552.1 218697885 7145371 complement(4808305..4808880) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1370290; Product type pr : regulator; transcriptional regulator 4808880 yjdC 7145371 yjdC Escherichia coli 55989 transcriptional regulator YP_002405552.1 4808305 R 585055 CDS YP_002405553.1 218697886 7149159 complement(4808917..4810614) 1 NC_011748.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein 4810614 dipZ 7149159 dipZ Escherichia coli 55989 thiol:disulfide interchange protein YP_002405553.1 4808917 R 585055 CDS YP_002405554.1 218697887 7145920 complement(4810590..4810928) 1 NC_011748.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA 4810928 cutA 7145920 cutA Escherichia coli 55989 divalent-cation tolerance protein CutA YP_002405554.1 4810590 R 585055 CDS YP_002405555.1 218697888 7145798 complement(4811044..4812345) 1 NC_011748.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter 4812345 dcuA 7145798 dcuA Escherichia coli 55989 anaerobic C4-dicarboxylate transporter YP_002405555.1 4811044 R 585055 CDS YP_002405556.1 218697889 7145860 complement(4812463..4813899) 1 NC_011748.1 catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase 4813899 aspA 7145860 aspA Escherichia coli 55989 aspartate ammonia-lyase YP_002405556.1 4812463 R 585055 CDS YP_002405557.1 218697890 7145571 4814236..4814712 1 NC_011748.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 4814712 fxsA 7145571 fxsA Escherichia coli 55989 FxsA protein YP_002405557.1 4814236 D 585055 CDS YP_002405558.1 218697891 7146235 complement(4814728..4815984) 1 NC_011748.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function; hypothetical protein 4815984 yjeH 7146235 yjeH Escherichia coli 55989 hypothetical protein YP_002405558.1 4814728 R 585055 CDS YP_002405559.1 218697892 7149169 4816260..4816553 1 NC_011748.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4816553 groES 7149169 groES Escherichia coli 55989 co-chaperonin GroES YP_002405559.1 4816260 D 585055 CDS YP_002405560.1 218697893 7146368 4816597..4818243 1 NC_011748.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 4818243 groEL 7146368 groEL Escherichia coli 55989 molecular chaperone GroEL YP_002405560.1 4816597 D 585055 CDS YP_002405561.1 218697894 7146367 4818381..4818734 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4818734 yjeI 7146367 yjeI Escherichia coli 55989 hypothetical protein YP_002405561.1 4818381 D 585055 CDS YP_002405562.1 218697895 7149170 complement(4818937..4819806) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4819806 yjeJ 7149170 yjeJ Escherichia coli 55989 hypothetical protein YP_002405562.1 4818937 R 585055 CDS YP_002405563.1 218697896 7149171 complement(4820196..4821224) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019591, 10629195; Product type pe : enzyme; lysine aminomutase 4821224 yjeK 7149171 yjeK Escherichia coli 55989 lysine aminomutase YP_002405563.1 4820196 R 585055 CDS YP_002405564.1 218697897 7149172 4821266..4821832 1 NC_011748.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4821832 efp 7149172 efp Escherichia coli 55989 elongation factor P YP_002405564.1 4821266 D 585055 CDS YP_002405565.1 218697898 7145981 4821884..4822009 1 NC_011748.1 acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex; entericidin A 4822009 ecnA 7145981 ecnA Escherichia coli 55989 entericidin A YP_002405565.1 4821884 D 585055 CDS YP_002405566.1 218697899 7145971 4822120..4822266 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98344100, 9677290; Product type lp : lipoprotein; entericidin B membrane lipoprotein 4822266 ecnB 7145971 ecnB Escherichia coli 55989 entericidin B membrane lipoprotein YP_002405566.1 4822120 D 585055 CDS YP_002405567.1 218697900 7145972 4822441..4822758 1 NC_011748.1 member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; quaternary ammonium compound-resistance protein SugE 4822758 sugE 7145972 sugE Escherichia coli 55989 quaternary ammonium compound-resistance protein SugE YP_002405567.1 4822441 D 585055 CDS YP_002405568.1 218697901 7147737 complement(4822755..4823288) 1 NC_011748.1 lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc 4823288 blc 7147737 blc Escherichia coli 55989 outer membrane lipoprotein Blc YP_002405568.1 4822755 R 585055 CDS YP_002405569.1 218697902 7145633 complement(4823377..4824510) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212899, 97464439, 99421326, 10595535, 6795623, 7041115, 9819201; Product type e : enzyme; beta-lactamase 4824510 ampC 7145633 ampC Escherichia coli 55989 beta-lactamase YP_002405569.1 4823377 R 585055 CDS YP_002405570.1 218697903 7145494 complement(4824573..4824932) 1 NC_011748.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D 4824932 frdD 7145494 frdD Escherichia coli 55989 fumarate reductase subunit D YP_002405570.1 4824573 R 585055 CDS YP_002405571.1 218697904 7146182 complement(4824943..4825338) 1 NC_011748.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C 4825338 frdC 7146182 frdC Escherichia coli 55989 fumarate reductase subunit C YP_002405571.1 4824943 R 585055 CDS YP_002405572.1 218697905 7146181 complement(4825349..4826083) 1 NC_011748.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit 4826083 frdB 7146181 frdB Escherichia coli 55989 fumarate reductase iron-sulfur subunit YP_002405572.1 4825349 R 585055 CDS YP_002405573.1 218697906 7146180 complement(4826076..4827884) 1 NC_011748.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit 4827884 frdA 7146180 frdA Escherichia coli 55989 fumarate reductase flavoprotein subunit YP_002405573.1 4826076 R 585055 CDS YP_002405574.1 218697907 7146179 4828209..4829186 1 NC_011748.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4829186 poxA 7146179 poxA Escherichia coli 55989 lysyl-tRNA synthetase YP_002405574.1 4828209 D 585055 CDS YP_002405575.1 218697908 7147218 4829405..4830907 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4830907 yjeM 7147218 yjeM Escherichia coli 55989 transporter YP_002405575.1 4829405 D 585055 CDS YP_002405576.1 218697909 7149173 4830959..4831273 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4831273 yjeN 7149173 yjeN Escherichia coli 55989 hypothetical protein YP_002405576.1 4830959 D 585055 CDS YP_002405577.1 218697910 7149174 4831270..4831584 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4831584 yjeO 7149174 yjeO Escherichia coli 55989 inner membrane protein YP_002405577.1 4831270 D 585055 CDS YP_002405578.1 218697911 7149175 complement(4831613..4834936) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; hypothetical protein 4834936 yjeP 7149175 yjeP Escherichia coli 55989 hypothetical protein YP_002405578.1 4831613 R 585055 CDS YP_002405579.1 218697912 7149176 complement(4834958..4835926) 1 NC_011748.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase 4835926 psd 7149176 psd Escherichia coli 55989 phosphatidylserine decarboxylase YP_002405579.1 4834958 R 585055 CDS YP_002405580.1 218697913 7147268 complement(4836023..4837075) 1 NC_011748.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase 4837075 rsgA 7147268 rsgA Escherichia coli 55989 ribosome-associated GTPase YP_002405580.1 4836023 R 585055 CDS YP_002405581.1 218697914 7147534 4837170..4837715 1 NC_011748.1 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4837715 orn 7147534 orn Escherichia coli 55989 oligoribonuclease YP_002405581.1 4837170 D 585055 CDS YP_002405582.1 218697915 7145366 complement(4838494..4839633) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; Fe-S electron transport protein 4839633 yjeS 7145366 yjeS Escherichia coli 55989 Fe-S electron transport protein YP_002405582.1 4838494 R 585055 CDS YP_002405583.1 218697916 7149177 4839632..4841179 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 4841179 yjeF 7149177 yjeF Escherichia coli 55989 hypothetical protein YP_002405583.1 4839632 D 585055 CDS YP_002405584.1 218697917 7149168 4841151..4841612 1 NC_011748.1 possibly involved in cell wall synthesis; ATPase 4841612 yjeE 7149168 yjeE Escherichia coli 55989 ATPase YP_002405584.1 4841151 D 585055 CDS YP_002405585.1 218697918 7149167 4841631..4842968 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 87242501, 1594459, 7511774; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase II 4842968 amiB 7149167 amiB Escherichia coli 55989 N-acetylmuramoyl-l-alanine amidase II YP_002405585.1 4841631 D 585055 CDS YP_002405586.1 218697919 7145491 4842978..4844825 1 NC_011748.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4844825 mutL 7145491 mutL Escherichia coli 55989 DNA mismatch repair protein YP_002405586.1 4842978 D 585055 CDS YP_002405587.1 218697920 7146932 4844818..4845768 1 NC_011748.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4845768 miaA 7146932 miaA Escherichia coli 55989 tRNA delta(2)-isopentenylpyrophosphate transferase YP_002405587.1 4844818 D 585055 CDS YP_002405588.1 218697921 7146852 4845854..4846162 1 NC_011748.1 Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4846162 hfq 7146852 hfq Escherichia coli 55989 RNA-binding protein Hfq YP_002405588.1 4845854 D 585055 CDS YP_002405589.1 218697922 7146424 4846239..4847519 1 NC_011748.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; GTPase HflX 4847519 hflX 7146424 hflX Escherichia coli 55989 GTPase HflX YP_002405589.1 4846239 D 585055 CDS YP_002405590.1 218697923 7146423 4847605..4848864 1 NC_011748.1 with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4848864 hflK 7146423 hflK Escherichia coli 55989 FtsH protease regulator HflK YP_002405590.1 4847605 D 585055 CDS YP_002405591.1 218697924 7146422 4848867..4849871 1 NC_011748.1 with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4849871 hflC 7146422 hflC Escherichia coli 55989 FtsH protease regulator HflC YP_002405591.1 4848867 D 585055 CDS YP_002405592.1 218697925 7146420 4849953..4850150 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4850150 yjeT 7146420 yjeT Escherichia coli 55989 inner membrane protein YP_002405592.1 4849953 D 585055 CDS YP_002405593.1 218697926 7149178 4850254..4851552 1 NC_011748.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4851552 purA 7149178 purA Escherichia coli 55989 adenylosuccinate synthetase YP_002405593.1 4850254 D 585055 CDS YP_002405594.1 218697927 7147292 4851757..4852182 1 NC_011748.1 negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4852182 nsrR 7147292 nsrR Escherichia coli 55989 transcriptional repressor NsrR YP_002405594.1 4851757 D 585055 CDS YP_002405595.1 218697928 7147034 4852221..4854662 1 NC_011748.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4854662 rnr 7147034 rnr Escherichia coli 55989 exoribonuclease R YP_002405595.1 4852221 D 585055 CDS YP_002405596.1 218697929 7147455 4854842..4855573 1 NC_011748.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4855573 rlmB 7147455 rlmB Escherichia coli 55989 23S rRNA (guanosine-2'-O-)-methyltransferase YP_002405596.1 4854842 D 585055 CDS YP_002405597.1 218697930 7147423 4855700..4856101 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4856101 yjfI 7147423 yjfI Escherichia coli 55989 hypothetical protein YP_002405597.1 4855700 D 585055 CDS YP_002405598.1 218697931 7149181 4856120..4856818 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator effector protein 4856818 yjfJ 7149181 yjfJ Escherichia coli 55989 transcriptional regulator effector protein YP_002405598.1 4856120 D 585055 CDS YP_002405599.1 218697932 7149182 4856869..4857528 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4857528 yjfK 7149182 yjfK Escherichia coli 55989 hypothetical protein YP_002405599.1 4856869 D 585055 CDS YP_002405600.1 218697933 7149183 4857546..4857944 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4857944 yjfL 7149183 yjfL Escherichia coli 55989 inner membrane protein YP_002405600.1 4857546 D 585055 CDS YP_002405601.1 218697934 7149184 complement(4857863..4857970) 1 NC_011748.1 hypothetical protein 4857970 7149184 EC55989_4740 Escherichia coli 55989 hypothetical protein YP_002405601.1 4857863 R 585055 CDS YP_002405602.1 218697935 7145156 4857954..4858592 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4858592 yjfM 7145156 yjfM Escherichia coli 55989 hypothetical protein YP_002405602.1 4857954 D 585055 CDS YP_002405603.1 218697936 7149185 4858595..4859758 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; synthetase/amidase 4859758 yjfC 7149185 yjfC Escherichia coli 55989 synthetase/amidase YP_002405603.1 4858595 D 585055 CDS YP_002405604.1 218697937 7149179 4859842..4861467 1 NC_011748.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4861467 aidB 7149179 aidB Escherichia coli 55989 isovaleryl CoA dehydrogenase YP_002405604.1 4859842 D 585055 CDS YP_002405605.1 218697938 7145476 complement(4861584..4861859) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4861859 yjfN 7145476 yjfN Escherichia coli 55989 hypothetical protein YP_002405605.1 4861584 R 585055 CDS YP_002405606.1 218697939 7149186 complement(4862008..4862337) 1 NC_011748.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; biofilm stress and motility protein A 4862337 yjfO 7149186 yjfO Escherichia coli 55989 biofilm stress and motility protein A YP_002405606.1 4862008 R 585055 CDS YP_002405607.1 218697940 7149187 4862519..4863268 1 NC_011748.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4863268 yjfP 7149187 yjfP Escherichia coli 55989 esterase YP_002405607.1 4862519 D 585055 CDS YP_002405608.1 218697941 7149188 complement(4863265..4864020) 1 NC_011748.1 negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR 4864020 ulaR 7149188 ulaR Escherichia coli 55989 transcriptional repressor UlaR YP_002405608.1 4863265 R 585055 CDS YP_002405609.1 218697942 7147920 complement(4864128..4865192) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12644495, 15808744; Product type pe : enzyme; L-ascorbate 6-phosphate lactonase 4865192 ulaG 7147920 ulaG Escherichia coli 55989 L-ascorbate 6-phosphate lactonase YP_002405609.1 4864128 R 585055 CDS YP_002405610.1 218697943 7147919 4865547..4866944 1 NC_011748.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4866944 ulaA 7147919 ulaA Escherichia coli 55989 PTS system ascorbate-specific transporter subunit IIC YP_002405610.1 4865547 D 585055 CDS YP_002405611.1 218697944 7147913 4866960..4867265 1 NC_011748.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 4867265 ulaB 7147913 ulaB Escherichia coli 55989 PTS system L-ascorbate-specific transporter subunit IIB YP_002405611.1 4866960 D 585055 CDS YP_002405612.1 218697945 7147914 4867275..4867739 1 NC_011748.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 4867739 ulaC 7147914 ulaC Escherichia coli 55989 PTS system L-ascorbate-specific transporter subunit IIA YP_002405612.1 4867275 D 585055 CDS YP_002405613.1 218697946 7147915 4867753..4868403 1 NC_011748.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4868403 ulaD 7147915 ulaD Escherichia coli 55989 3-keto-L-gulonate-6-phosphate decarboxylase YP_002405613.1 4867753 D 585055 CDS YP_002405614.1 218697947 7147916 4868413..4869267 1 NC_011748.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4869267 ulaE 7147916 ulaE Escherichia coli 55989 L-xylulose 5-phosphate 3-epimerase YP_002405614.1 4868413 D 585055 CDS YP_002405615.1 218697948 7147917 4869267..4869953 1 NC_011748.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4869953 sgaE 7147917 sgaE Escherichia coli 55989 L-ribulose-5-phosphate 4-epimerase YP_002405615.1 4869267 D 585055 CDS YP_002405616.1 218697949 7147918 4870050..4870601 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; Inner membrane protein yagU 4870601 yagU 7147918 yagU Escherichia coli 55989 Inner membrane protein yagU YP_002405616.1 4870050 D 585055 CDS YP_002405617.1 218697950 7148054 complement(4870676..4870951) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4870951 yjfY 7148054 yjfY Escherichia coli 55989 hypothetical protein YP_002405617.1 4870676 R 585055 CDS YP_002405618.1 218697951 7149189 4871278..4871673 1 NC_011748.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4871673 rpsF 7149189 rpsF Escherichia coli 55989 30S ribosomal protein S6 YP_002405618.1 4871278 D 585055 CDS YP_002405619.1 218697952 7147510 4871680..4871994 1 NC_011748.1 binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 4871994 priB 7147510 priB Escherichia coli 55989 primosomal replication protein N YP_002405619.1 4871680 D 585055 CDS YP_002405620.1 218697953 7147245 4871999..4872226 1 NC_011748.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4872226 rpsR 7147245 rpsR Escherichia coli 55989 30S ribosomal protein S18 YP_002405620.1 4871999 D 585055 CDS YP_002405621.1 218697954 7147522 4872268..4872717 1 NC_011748.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4872717 rplI 7147522 rplI Escherichia coli 55989 50S ribosomal protein L9 YP_002405621.1 4872268 D 585055 CDS YP_002405622.1 218697955 7147469 complement(4872788..4873582) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4873582 yjfZ 7147469 yjfZ Escherichia coli 55989 hypothetical protein YP_002405622.1 4872788 R 585055 CDS YP_002405623.1 218697956 7149190 4873929..4874351 1 NC_011748.1 hypothetical protein 4874351 7149190 EC55989_4763 Escherichia coli 55989 hypothetical protein YP_002405623.1 4873929 D 585055 CDS YP_002405624.1 218697957 7145157 complement(4874205..4874636) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase 4874636 7145157 EC55989_4764 Escherichia coli 55989 transposase YP_002405624.1 4874205 R 585055 CDS YP_002405625.1 218697958 7145158 4874644..4875852 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase 4875852 ydcM 7145158 ydcM Escherichia coli 55989 transposase YP_002405625.1 4874644 D 585055 CDS YP_002405626.1 218697959 7148393 complement(4875987..4876625) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8559074; Product type ps : structure; cell envelope opacity-associated protein 4876625 ytfB 7148393 ytfB Escherichia coli 55989 cell envelope opacity-associated protein YP_002405626.1 4875987 R 585055 CDS YP_002405627.1 218697960 7149469 4876844..4877464 1 NC_011748.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4877464 fklB 7149469 fklB Escherichia coli 55989 peptidyl-prolyl cis-trans isomerase YP_002405627.1 4876844 D 585055 CDS YP_002405628.1 218697961 7146119 4877773..4879185 1 NC_011748.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4879185 cycA 7146119 cycA Escherichia coli 55989 D-alanine/D-serine/glycine permease YP_002405628.1 4877773 D 585055 CDS YP_002405629.1 218697962 7145806 complement(4879230..4879892) 1 NC_011748.1 Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein 4879892 ytfE 7145806 ytfE Escherichia coli 55989 iron-sulfur cluster repair di-iron protein YP_002405629.1 4879230 R 585055 CDS YP_002405630.1 218697963 7149470 complement(4880000..4880974) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4880974 ytfF 7149470 ytfF Escherichia coli 55989 inner membrane protein YP_002405630.1 4880000 R 585055 CDS YP_002405631.1 218697964 7149471 complement(4881073..4881933) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14747727; Product type e : enzyme; NAD(P)H:quinone oxidoreductase 4881933 ytfG 7149471 ytfG Escherichia coli 55989 NAD(P)H:quinone oxidoreductase YP_002405631.1 4881073 R 585055 CDS YP_002405632.1 218697965 7149472 4882022..4882402 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20088838; Product type pr : regulator; transcriptional regulator 4882402 ytfH 7149472 ytfH Escherichia coli 55989 transcriptional regulator YP_002405632.1 4882022 D 585055 CDS YP_002405633.1 218697966 7149473 complement(4882531..4884474) 1 NC_011748.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein 4884474 cpdB 7149473 cpdB Escherichia coli 55989 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein YP_002405633.1 4882531 R 585055 CDS YP_002405634.1 218697967 7145745 4884664..4885404 1 NC_011748.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 4885404 cysQ 7145745 cysQ Escherichia coli 55989 adenosine-3'(2'),5'-bisphosphate nucleotidase YP_002405634.1 4884664 D 585055 CDS YP_002405635.1 218697968 7145833 complement(4885394..4885951) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pr : regulator; transcriptional regulator 4885951 ytfJ 7145833 ytfJ Escherichia coli 55989 transcriptional regulator YP_002405635.1 4885394 R 585055 CDS YP_002405636.1 218697969 7149474 4886276..4886482 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4886482 ytfK 7149474 ytfK Escherichia coli 55989 hypothetical protein YP_002405636.1 4886276 D 585055 CDS YP_002405637.1 218697970 7149475 complement(4886544..4887887) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4887887 ytfL 7149475 ytfL Escherichia coli 55989 inner membrane protein YP_002405637.1 4886544 R 585055 CDS YP_002405638.1 218697971 7149476 complement(4888210..4888848) 1 NC_011748.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A 4888848 msrA 7149476 msrA Escherichia coli 55989 methionine sulfoxide reductase A YP_002405638.1 4888210 R 585055 CDS YP_002405639.1 218697972 7146910 4889054..4890787 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; outer membrane protein 4890787 ytfM 7146910 ytfM Escherichia coli 55989 outer membrane protein YP_002405639.1 4889054 D 585055 CDS YP_002405640.1 218697973 7149477 4890784..4894563 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4894563 ytfN 7149477 ytfN Escherichia coli 55989 hypothetical protein YP_002405640.1 4890784 D 585055 CDS YP_002405641.1 218697974 7149478 4894566..4894907 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4894907 ytfP 7149478 ytfP Escherichia coli 55989 hypothetical protein YP_002405641.1 4894566 D 585055 CDS YP_002405642.1 218697975 7149479 4895119..4895370 1 NC_011748.1 part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 4895370 chpS 7149479 chpS Escherichia coli 55989 antitoxin ChpS YP_002405642.1 4895119 D 585055 CDS YP_002405643.1 218697976 7145706 4895364..4895714 1 NC_011748.1 toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 4895714 chpB 7145706 chpB Escherichia coli 55989 toxin ChpB YP_002405643.1 4895364 D 585055 CDS YP_002405644.1 218697977 7145704 complement(4895794..4896324) 1 NC_011748.1 catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase 4896324 ppa 7145704 ppa Escherichia coli 55989 inorganic pyrophosphatase YP_002405644.1 4895794 R 585055 CDS YP_002405645.1 218697978 7147220 4896634..4897590 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : transporter; sugar transporter subunit: periplasmic-binding component of ABC superfamily 4897590 ytfQ 7147220 ytfQ Escherichia coli 55989 sugar transporter subunit: periplasmic-binding component of ABC superfamily YP_002405645.1 4896634 D 585055 CDS YP_002405646.1 218697979 7149480 4897900..4899402 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sugar transporter subunit: ATP-binding component of ABC superfamily 4899402 ytfR 7149480 ytfR Escherichia coli 55989 sugar transporter subunit: ATP-binding component of ABC superfamily YP_002405646.1 4897900 D 585055 CDS YP_002405647.1 218697980 7149481 4899416..4900438 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sugar transporter subunit: membrane component of ABC superfamily 4900438 ytfT 7149481 ytfT Escherichia coli 55989 sugar transporter subunit: membrane component of ABC superfamily YP_002405647.1 4899416 D 585055 CDS YP_002405648.1 218697981 7149482 4900425..4901420 1 NC_011748.1 membrane component of a sugar ABC transporter system; ABC transporter permease 4901420 yjfF 7149482 yjfF Escherichia coli 55989 ABC transporter permease YP_002405648.1 4900425 D 585055 CDS YP_002405649.1 218697982 7149180 complement(4901453..4902451) 1 NC_011748.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase 4902451 fbp 7149180 fbp Escherichia coli 55989 fructose-1,6-bisphosphatase YP_002405649.1 4901453 R 585055 CDS YP_002405650.1 218697983 7146064 4902627..4904000 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96404780, 2843822, 7984428, 8808921; Product type e : enzyme; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 4904000 mpl 7146064 mpl Escherichia coli 55989 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase YP_002405650.1 4902627 D 585055 CDS YP_002405651.1 218697984 7146891 complement(4904151..4904702) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4904702 yjgA 7146891 yjgA Escherichia coli 55989 hypothetical protein YP_002405651.1 4904151 R 585055 CDS YP_002405652.1 218697985 7149191 4904796..4906148 1 NC_011748.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 4906148 pmbA 7149191 pmbA Escherichia coli 55989 peptidase PmbA YP_002405652.1 4904796 D 585055 CDS YP_002405653.1 218697986 7147199 4906331..4906717 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1761034, 8499452, 10393541; Product type c : carrier; soluble cytochrome b562 4906717 cybC 7147199 cybC Escherichia coli 55989 soluble cytochrome b562 YP_002405653.1 4906331 D 585055 CDS YP_002405654.1 218697987 7145805 complement(4906762..4907226) 1 NC_011748.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein 4907226 nrdG 7145805 nrdG Escherichia coli 55989 anaerobic ribonucleotide reductase-activating protein YP_002405654.1 4906762 R 585055 CDS YP_002405655.1 218697988 7147023 complement(4907384..4909522) 1 NC_011748.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase 4909522 nrdD 7147023 nrdD Escherichia coli 55989 anaerobic ribonucleoside triphosphate reductase YP_002405655.1 4907384 R 585055 CDS YP_002405656.1 218697989 7147020 complement(4909925..4911580) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264345, 93302496, 8083158, 8421692; Product type e : enzyme; trehalose-6-phosphate hydrolase 4911580 treC 7147020 treC Escherichia coli 55989 trehalose-6-phosphate hydrolase YP_002405656.1 4909925 R 585055 CDS YP_002405657.1 218697990 7147837 complement(4911630..4913051) 1 NC_011748.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunit IIBC 4913051 treB 7147837 treB Escherichia coli 55989 PTS system trehalose(maltose)-specific transporter subunit IIBC YP_002405657.1 4911630 R 585055 CDS YP_002405658.1 218697991 7147836 complement(4913170..4914117) 1 NC_011748.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor 4914117 treR 7147836 treR Escherichia coli 55989 trehalose repressor YP_002405658.1 4913170 R 585055 CDS YP_002405659.1 218697992 7147839 4914496..4917192 1 NC_011748.1 P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 4917192 mgtA 7147839 mgtA Escherichia coli 55989 magnesium-transporting ATPase MgtA YP_002405659.1 4914496 D 585055 CDS YP_002405660.1 218697993 7146843 complement(4917420..4918400) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 4918400 7146843 EC55989_4801 Escherichia coli 55989 transposase, IS110 family YP_002405660.1 4917420 R 585055 CDS YP_002405661.1 218697994 7145159 complement(4918677..4919063) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12515541, 10493123, 10595546, 9298646; Product type pe : enzyme; ketoacid-binding protein 4919063 yjgF 7145159 yjgF Escherichia coli 55989 ketoacid-binding protein YP_002405661.1 4918677 R 585055 CDS YP_002405662.1 218697995 7149194 complement(4919136..4919597) 1 NC_011748.1 involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase 4919597 pyrI 7149194 pyrI Escherichia coli 55989 aspartate carbamoyltransferase YP_002405662.1 4919136 R 585055 CDS YP_002405663.1 218697996 7147324 complement(4919610..4920545) 1 NC_011748.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase 4920545 pyrB 7147324 pyrB Escherichia coli 55989 aspartate carbamoyltransferase YP_002405663.1 4919610 R 585055 CDS YP_002405664.1 218697997 7147317 complement(4920549..4920683) 1 NC_011748.1 Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; pyrBI operon leader peptide 4920683 pyrL 7147317 pyrL Escherichia coli 55989 pyrBI operon leader peptide YP_002405664.1 4920549 R 585055 CDS YP_002405665.1 218697998 7147325 complement(4920964..4921359) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; mRNA endoribonuclease 4921359 yjgH 7147325 yjgH Escherichia coli 55989 mRNA endoribonuclease YP_002405665.1 4920964 R 585055 CDS YP_002405666.1 218697999 7149195 complement(4921490..4922203) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase 4922203 yjgI 7149195 yjgI Escherichia coli 55989 oxidoreductase YP_002405666.1 4921490 R 585055 CDS YP_002405667.1 218698000 7149196 4922274..4922867 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 4922867 yjgJ 7149196 yjgJ Escherichia coli 55989 transcriptional regulator YP_002405667.1 4922274 D 585055 CDS YP_002405668.1 218698001 7149197 4923012..4923464 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11115104; hypothetical protein 4923464 yjgK 7149197 yjgK Escherichia coli 55989 hypothetical protein YP_002405668.1 4923012 D 585055 CDS YP_002405669.1 218698002 7149200 complement(4925249..4926253) 1 NC_011748.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I 4926253 argI 7149200 argI Escherichia coli 55989 ornithine carbamoyltransferase subunit I YP_002405669.1 4925249 R 585055 CDS YP_002405670.1 218698003 7145531 4926415..4926831 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4926831 yjgD 7145531 yjgD Escherichia coli 55989 hypothetical protein YP_002405670.1 4926415 D 585055 CDS YP_002405671.1 218698004 7149193 complement(4926877..4927380) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acetyltransferase 4927380 yjgM 7149193 yjgM Escherichia coli 55989 acetyltransferase YP_002405671.1 4926877 R 585055 CDS YP_002405672.1 218698005 7149201 4927573..4928769 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4928769 yjgN 7149201 yjgN Escherichia coli 55989 inner membrane protein YP_002405672.1 4927573 D 585055 CDS YP_002405673.1 218698006 7149202 complement(4928825..4931680) 1 NC_011748.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase 4931680 valS 7149202 valS Escherichia coli 55989 valyl-tRNA synthetase YP_002405673.1 4928825 R 585055 CDS YP_002405674.1 218698007 7147946 complement(4931680..4932123) 1 NC_011748.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi 4932123 holC 7147946 holC Escherichia coli 55989 DNA polymerase III subunit chi YP_002405674.1 4931680 R 585055 CDS YP_002405675.1 218698008 7146455 complement(4932257..4933768) 1 NC_011748.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase 4933768 pepA 7146455 pepA Escherichia coli 55989 leucyl aminopeptidase YP_002405675.1 4932257 R 585055 CDS YP_002405676.1 218698009 7147130 4934035..4935135 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4935135 yjgP 7147130 yjgP Escherichia coli 55989 inner membrane protein YP_002405676.1 4934035 D 585055 CDS YP_002405677.1 218698010 7149203 4935135..4936217 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4936217 yjgQ 7149203 yjgQ Escherichia coli 55989 inner membrane protein YP_002405677.1 4935135 D 585055 CDS YP_002405678.1 218698011 7149204 complement(4936336..4937838) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; ATPase 4937838 yjgR 7149204 yjgR Escherichia coli 55989 ATPase YP_002405678.1 4936336 R 585055 CDS YP_002405679.1 218698012 7149205 complement(4937916..4938914) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9119199, 98324983, 9658018; Product type r : regulator; DNA-binding transcriptional repressor, 5-gluconate-binding 4938914 idnR 7149205 idnR Escherichia coli 55989 DNA-binding transcriptional repressor, 5-gluconate-binding YP_002405679.1 4937916 R 585055 CDS YP_002405680.1 218698013 7146543 complement(4938981..4940300) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 9119199, 93139975, 98324983, 9658018; Product type t : transporter; L-idonate and D-gluconate transporter 4940300 idnT 7146543 idnT Escherichia coli 55989 L-idonate and D-gluconate transporter YP_002405680.1 4938981 R 585055 CDS YP_002405681.1 218698014 7146544 complement(4940365..4941129) 1 NC_011748.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase 4941129 idnO 7146544 idnO Escherichia coli 55989 gluconate 5-dehydrogenase YP_002405681.1 4940365 R 585055 CDS YP_002405682.1 218698015 7146542 complement(4941153..4942184) 1 NC_011748.1 NAD-binding; L-idonate 5-dehydrogenase 4942184 idnD 7146542 idnD Escherichia coli 55989 L-idonate 5-dehydrogenase YP_002405682.1 4941153 R 585055 CDS YP_002405683.1 218698016 7146540 4942401..4942964 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87310381, 93139975, 98324983, 9658018, 14832279; Product type e : enzyme; D-gluconate kinase 4942964 idnK 7146540 idnK Escherichia coli 55989 D-gluconate kinase YP_002405683.1 4942401 D 585055 CDS YP_002405684.1 218698017 7146541 complement(4942968..4943987) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12147722; Product type pe : enzyme; alcohol dehydrogenase, Zn-dependent and NAD(P)-binding 4943987 yjgB 7146541 yjgB Escherichia coli 55989 alcohol dehydrogenase, Zn-dependent and NAD(P)-binding YP_002405684.1 4942968 R 585055 CDS YP_002405685.1 218698018 7149192 complement(4944062..4944268) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4944268 7149192 EC55989_4828 Escherichia coli 55989 hypothetical protein YP_002405685.1 4944062 R 585055 CDS YP_002405686.1 218698019 7145367 4944529..4945719 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; integrase; KpLE2 phage-like element 4945719 intB 7145367 intB Escherichia coli 55989 integrase; KpLE2 phage-like element YP_002405686.1 4944529 D 585055 CDS YP_002405687.1 218698020 7146608 complement(4946043..4947542) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane-associated, metal-dependent hydrolase 4947542 7146608 EC55989_4830 Escherichia coli 55989 membrane-associated, metal-dependent hydrolase YP_002405687.1 4946043 R 585055 CDS YP_002405688.1 218698021 7145161 complement(4947716..4948507) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type f : factor; surface protein precursor 4948507 7145161 EC55989_4831 Escherichia coli 55989 surface protein precursor YP_002405688.1 4947716 R 585055 CDS YP_002405689.1 218698022 7145162 4949069..4950718 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4950718 7145162 EC55989_4832 Escherichia coli 55989 hypothetical protein YP_002405689.1 4949069 D 585055 CDS YP_002405690.1 218698023 7145163 4950723..4952048 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4952048 7145163 EC55989_4833 Escherichia coli 55989 hypothetical protein YP_002405690.1 4950723 D 585055 CDS YP_002405691.1 218698024 7145164 4952008..4957083 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4957083 7145164 EC55989_4834 Escherichia coli 55989 hypothetical protein YP_002405691.1 4952008 D 585055 CDS YP_002405692.1 218698025 7145165 4957121..4957639 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4957639 7145165 EC55989_4835 Escherichia coli 55989 hypothetical protein YP_002405692.1 4957121 D 585055 CDS YP_002405693.1 218698026 7145166 4957640..4957945 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4957945 7145166 EC55989_4836 Escherichia coli 55989 hypothetical protein YP_002405693.1 4957640 D 585055 CDS YP_002405694.1 218698027 7145167 4958207..4958800 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4958800 7145167 EC55989_4837 Escherichia coli 55989 hypothetical protein YP_002405694.1 4958207 D 585055 CDS YP_002405695.1 218698028 7145168 complement(4958859..4959215) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16102010; Product type pe : enzyme; DNA thiolation protein; phage protein 4959215 7145168 EC55989_4838 Escherichia coli 55989 DNA thiolation protein; phage protein YP_002405695.1 4958859 R 585055 CDS YP_002405696.1 218698029 7145169 complement(4959215..4961263) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16102010; Product type pe : enzyme; ATPase involved in DNA thiolation 4961263 7145169 EC55989_4839 Escherichia coli 55989 ATPase involved in DNA thiolation YP_002405696.1 4959215 R 585055 CDS YP_002405697.1 218698030 7145170 complement(4961205..4962839) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16102010; Product type pe : enzyme; hypothetical protein 4962839 7145170 EC55989_4840 Escherichia coli 55989 hypothetical protein YP_002405697.1 4961205 R 585055 CDS YP_002405698.1 218698031 7145171 complement(4962836..4963921) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16102010; Product type pe : enzyme; DNA thiolation protein; phage protein 4963921 7145171 EC55989_4841 Escherichia coli 55989 DNA thiolation protein; phage protein YP_002405698.1 4962836 R 585055 CDS YP_002405699.1 218698032 7145172 complement(4964136..4964288) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4964288 7145172 EC55989_4842 Escherichia coli 55989 hypothetical protein YP_002405699.1 4964136 R 585055 CDS YP_002405700.1 218698033 7145173 4964384..4964557 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4964557 7145173 EC55989_4843 Escherichia coli 55989 hypothetical protein YP_002405700.1 4964384 D 585055 CDS YP_002405701.1 218698034 7145174 4964554..4964898 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; conjugation inhibition protein, immunity protein 4964898 7145174 EC55989_4844 Escherichia coli 55989 conjugation inhibition protein, immunity protein YP_002405701.1 4964554 D 585055 CDS YP_002405702.1 218698035 7145175 complement(4964917..4965516) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4965516 7145175 EC55989_4845 Escherichia coli 55989 hypothetical protein YP_002405702.1 4964917 R 585055 CDS YP_002405703.1 218698036 7145176 complement(4965553..4965711) 1 NC_011748.1 hypothetical protein 4965711 7145176 EC55989_4846 Escherichia coli 55989 hypothetical protein YP_002405703.1 4965553 R 585055 CDS YP_002405704.1 218698037 7145177 complement(4965708..4965944) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; phage regulatory protein 4965944 7145177 EC55989_4847 Escherichia coli 55989 phage regulatory protein YP_002405704.1 4965708 R 585055 CDS YP_002405705.1 218698038 7145178 complement(4966013..4966720) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4966720 7145178 EC55989_4848 Escherichia coli 55989 hypothetical protein YP_002405705.1 4966013 R 585055 CDS YP_002405706.1 218698039 7145179 complement(4966835..4967302) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4967302 7145179 EC55989_4849 Escherichia coli 55989 hypothetical protein YP_002405706.1 4966835 R 585055 CDS YP_002405707.1 218698040 7147438 4967418..4968626 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L 4968626 7147438 EC55989_4850 Escherichia coli 55989 transposase, IS4 family, IS10L YP_002405707.1 4967418 D 585055 CDS YP_002405708.1 218698041 7145181 complement(4968992..4969273) 1 NC_011748.1 hypothetical protein 4969273 7145181 EC55989_4851 Escherichia coli 55989 hypothetical protein YP_002405708.1 4968992 R 585055 CDS YP_002405709.1 218698042 7145182 complement(4969248..4970456) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L 4970456 7145182 EC55989_4852 Escherichia coli 55989 transposase, IS4 family, IS10L YP_002405709.1 4969248 R 585055 CDS YP_002405710.1 218698043 7145183 complement(4970396..4971535) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4971535 7145183 EC55989_4853 Escherichia coli 55989 hypothetical protein YP_002405710.1 4970396 R 585055 CDS YP_002405711.1 218698044 7147439 4971979..4972299 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; monooxygenase 4972299 7147439 EC55989_4854 Escherichia coli 55989 monooxygenase YP_002405711.1 4971979 D 585055 CDS YP_002405712.1 218698045 7145185 4972181..4972678 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4972678 7145185 EC55989_4855 Escherichia coli 55989 hypothetical protein YP_002405712.1 4972181 D 585055 CDS YP_002405713.1 218698046 7145186 4972686..4973372 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; ArsR family transcriptional regulator 4973372 7145186 EC55989_4856 Escherichia coli 55989 ArsR family transcriptional regulator YP_002405713.1 4972686 D 585055 CDS YP_002405714.1 218698047 7145187 complement(4973350..4973976) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type r : regulator; tetracycline repressor protein TetR 4973976 7145187 EC55989_4857 Escherichia coli 55989 tetracycline repressor protein TetR YP_002405714.1 4973350 R 585055 CDS YP_002405715.1 218698048 7145188 4974007..4975260 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pt : transporter; Tetracycline resistance protein, class B (TETA(B) ) (Metal-tetracycline/H(+) antiporter) 4975260 7145188 EC55989_4858 Escherichia coli 55989 Tetracycline resistance protein, class B (TETA(B) ) (Metal-tetracycline/H(+) antiporter) YP_002405715.1 4974007 D 585055 CDS YP_002405716.1 218698049 7145189 complement(4975373..4976041) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; Transcriptional regulator 4976041 7145189 EC55989_4859 Escherichia coli 55989 Transcriptional regulator YP_002405716.1 4975373 R 585055 CDS YP_002405717.1 218698050 7145190 4976054..4976470 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; operon control protein 4976470 7145190 EC55989_4860 Escherichia coli 55989 operon control protein YP_002405717.1 4976054 D 585055 CDS YP_002405718.1 218698051 7145191 complement(4976480..4977688) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L 4977688 7145191 EC55989_4861 Escherichia coli 55989 transposase, IS4 family, IS10L YP_002405718.1 4976480 R 585055 CDS YP_002405719.1 218698052 7145299 complement(4979387..4980142) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4980142 7145299 EC55989_4862 Escherichia coli 55989 hypothetical protein YP_002405719.1 4979387 R 585055 CDS YP_002405720.1 218698053 7145193 complement(4980287..4980556) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4980556 7145193 EC55989_4863 Escherichia coli 55989 hypothetical protein YP_002405720.1 4980287 R 585055 CDS YP_002405721.1 218698054 7145194 4980643..4980951 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin; IS3 element protein InsE 4980951 insE 7145194 insE Escherichia coli 55989 IS3 element protein InsE YP_002405721.1 4980643 D 585055 CDS YP_002405722.1 218698055 7146593 4980948..4981814 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin; IS3 element protein InsF 4981814 insF 7146593 insF Escherichia coli 55989 IS3 element protein InsF YP_002405722.1 4980948 D 585055 CDS YP_002405723.1 218698056 7146595 complement(4981951..4982742) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4982742 7146595 EC55989_4866 Escherichia coli 55989 hypothetical protein YP_002405723.1 4981951 R 585055 CDS YP_002405724.1 218698057 7145195 complement(4982813..4983634) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4983634 7145195 EC55989_4867 Escherichia coli 55989 hypothetical protein YP_002405724.1 4982813 R 585055 CDS YP_002405725.1 218698058 7145196 complement(4983672..4984373) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4984373 7145196 EC55989_4868 Escherichia coli 55989 hypothetical protein YP_002405725.1 4983672 R 585055 CDS YP_002405726.1 218698059 7145197 complement(4984370..4984945) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4984945 7145197 EC55989_4869 Escherichia coli 55989 hypothetical protein YP_002405726.1 4984370 R 585055 CDS YP_002405727.1 218698060 7145198 complement(4985107..4985910) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4985910 7145198 EC55989_4870 Escherichia coli 55989 hypothetical protein YP_002405727.1 4985107 R 585055 CDS YP_002405728.1 218698061 7145199 4985699..4986049 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4986049 7145199 EC55989_4871 Escherichia coli 55989 hypothetical protein YP_002405728.1 4985699 D 585055 CDS YP_002405729.1 218698062 7145200 4986234..4986908 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4986908 7145200 EC55989_4872 Escherichia coli 55989 hypothetical protein YP_002405729.1 4986234 D 585055 CDS YP_002405730.1 218698063 7145201 complement(4987187..4987963) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4987963 7145201 EC55989_4873 Escherichia coli 55989 hypothetical protein YP_002405730.1 4987187 R 585055 CDS YP_002405731.1 218698064 7145202 complement(4987966..4988475) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4988475 7145202 EC55989_4874 Escherichia coli 55989 hypothetical protein YP_002405731.1 4987966 R 585055 CDS YP_002405732.1 218698065 7145203 4988634..4989155 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4989155 7145203 EC55989_4875 Escherichia coli 55989 hypothetical protein YP_002405732.1 4988634 D 585055 CDS YP_002405733.1 218698066 7145204 4989073..4989594 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4989594 7145204 EC55989_4876 Escherichia coli 55989 hypothetical protein YP_002405733.1 4989073 D 585055 CDS YP_002405734.1 218698067 7145205 4989608..4990630 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase ORF A, IS100 4990630 7145205 EC55989_4877 Escherichia coli 55989 transposase ORF A, IS100 YP_002405734.1 4989608 D 585055 CDS YP_002405735.1 218698068 7145206 4990627..4991409 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase/IS protein 4991409 7145206 EC55989_4878 Escherichia coli 55989 transposase/IS protein YP_002405735.1 4990627 D 585055 CDS YP_002405736.1 218698069 7145207 complement(4991534..4991707) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4991707 7145207 EC55989_4879 Escherichia coli 55989 hypothetical protein YP_002405736.1 4991534 R 585055 CDS YP_002405737.1 218698070 7145208 complement(4991625..4992356) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4992356 7145208 EC55989_4880 Escherichia coli 55989 hypothetical protein YP_002405737.1 4991625 R 585055 CDS YP_002405738.1 218698071 7145209 complement(4992698..4992886) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4992886 7145209 EC55989_4881 Escherichia coli 55989 hypothetical protein YP_002405738.1 4992698 R 585055 CDS YP_002405739.1 218698072 7145210 4993026..4993556 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4993556 7145210 EC55989_4882 Escherichia coli 55989 hypothetical protein YP_002405739.1 4993026 D 585055 CDS YP_002405740.1 218698073 7145211 complement(4994306..4994485) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4994485 7145211 EC55989_4883 Escherichia coli 55989 hypothetical protein YP_002405740.1 4994306 R 585055 CDS YP_002405741.1 218698074 7145212 4995161..4996030 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4996030 7145212 EC55989_4884 Escherichia coli 55989 hypothetical protein YP_002405741.1 4995161 D 585055 CDS YP_002405742.1 218698075 7145213 complement(4996027..4996989) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4996989 7145213 EC55989_4885 Escherichia coli 55989 hypothetical protein YP_002405742.1 4996027 R 585055 CDS YP_002405743.1 218698076 7145214 4997095..4997979 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; GTP-binding protein 4997979 7145214 EC55989_4886 Escherichia coli 55989 GTP-binding protein YP_002405743.1 4997095 D 585055 CDS YP_002405744.1 218698077 7145215 4998182..4998862 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; HTH-type transcriptional regulator 4998862 yfjR 7145215 yfjR Escherichia coli 55989 HTH-type transcriptional regulator YP_002405744.1 4998182 D 585055 CDS YP_002405745.1 218698078 7148787 4998905..4999687 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4999687 7148787 EC55989_4888 Escherichia coli 55989 hypothetical protein YP_002405745.1 4998905 D 585055 CDS YP_002405746.1 218698079 7145216 4999693..4999926 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4999926 7145216 EC55989_4889 Escherichia coli 55989 hypothetical protein YP_002405746.1 4999693 D 585055 CDS YP_002405747.1 218698080 7145217 5000016..5000834 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5000834 7145217 EC55989_4890 Escherichia coli 55989 hypothetical protein YP_002405747.1 5000016 D 585055 CDS YP_002405748.1 218698081 7145218 5000926..5001411 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; antirestriction protein 5001411 7145218 EC55989_4891 Escherichia coli 55989 antirestriction protein YP_002405748.1 5000926 D 585055 CDS YP_002405749.1 218698082 7145219 5001456..5001902 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : factor; DNA repair protein; CP4-44 prophage 5001902 yeeS 7145219 yeeS Escherichia coli 55989 DNA repair protein; CP4-44 prophage YP_002405749.1 5001456 D 585055 CDS YP_002405750.1 218698083 7148607 5001989..5002210 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; CP4-44 prophage 5002210 yeeT 7148607 yeeT Escherichia coli 55989 CP4-44 prophage YP_002405750.1 5001989 D 585055 CDS YP_002405751.1 218698084 7148611 5002290..5002658 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; antitoxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 5002658 yeeU 7148611 yeeU Escherichia coli 55989 antitoxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage YP_002405751.1 5002290 D 585055 CDS YP_002405752.1 218698085 7148615 5002607..5003125 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; phage protein 5003125 7148615 EC55989_4895 Escherichia coli 55989 phage protein YP_002405752.1 5002607 D 585055 CDS YP_002405753.1 218698086 7145220 5003122..5003610 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5003610 yeeW 7145220 yeeW Escherichia coli 55989 hypothetical protein YP_002405753.1 5003122 D 585055 CDS YP_002405754.1 218698087 7148622 5003258..5003827 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 5003827 7148622 EC55989_4897 Escherichia coli 55989 hypothetical protein YP_002405754.1 5003258 D 585055 CDS YP_002405755.1 218698088 7145221 5003912..5004058 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5004058 7145221 EC55989_4898 Escherichia coli 55989 hypothetical protein YP_002405755.1 5003912 D 585055 CDS YP_002405756.1 218698089 7145222 complement(5004471..5005478) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5005478 7145222 EC55989_4899 Escherichia coli 55989 hypothetical protein YP_002405756.1 5004471 R 585055 CDS YP_002405757.1 218698090 7145223 complement(5005387..5007006) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5007006 7145223 EC55989_4900 Escherichia coli 55989 hypothetical protein YP_002405757.1 5005387 R 585055 CDS YP_002405758.1 218698091 7145224 complement(5007016..5008350) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5008350 7145224 EC55989_4901 Escherichia coli 55989 hypothetical protein YP_002405758.1 5007016 R 585055 CDS YP_002405759.1 218698092 7145225 complement(5008307..5008633) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5008633 7145225 EC55989_4902 Escherichia coli 55989 hypothetical protein YP_002405759.1 5008307 R 585055 CDS YP_002405760.1 218698093 7145226 complement(5008968..5009840) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5009840 7145226 EC55989_4903 Escherichia coli 55989 hypothetical protein YP_002405760.1 5008968 R 585055 CDS YP_002405761.1 218698094 7145227 complement(5010085..5010465) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 5010465 7145227 EC55989_4904 Escherichia coli 55989 hypothetical protein YP_002405761.1 5010085 R 585055 CDS YP_002405762.1 218698095 7145228 complement(5010519..5011022) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 273224, 375010, 1849492; Product type pe : enzyme; Insertion element IS1 1/5/6 protein insB 5011022 7145228 EC55989_4905 Escherichia coli 55989 Insertion element IS1 1/5/6 protein insB YP_002405762.1 5010519 R 585055 CDS YP_002405763.1 218698096 7145229 complement(5010941..5011216) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1849492; Product type r : regulator; IS1 repressor protein InsA 5011216 7145229 EC55989_4906 Escherichia coli 55989 IS1 repressor protein InsA YP_002405763.1 5010941 R 585055 CDS YP_002405764.1 218698097 7145230 5011595..5011744 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5011744 7145230 EC55989_4907 Escherichia coli 55989 hypothetical protein YP_002405764.1 5011595 D 585055 CDS YP_002405765.1 218698098 7145231 5012004..5012300 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 5012300 7145231 EC55989_4908 Escherichia coli 55989 transcriptional regulator YP_002405765.1 5012004 D 585055 CDS YP_002405766.1 218698099 7145232 5012450..5012629 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5012629 7145232 EC55989_4909 Escherichia coli 55989 hypothetical protein YP_002405766.1 5012450 D 585055 CDS YP_002405767.1 218698100 7145233 5012590..5012769 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5012769 7145233 EC55989_4910 Escherichia coli 55989 hypothetical protein YP_002405767.1 5012590 D 585055 CDS YP_002405768.1 218698101 7145234 complement(5012734..5012889) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5012889 7145234 EC55989_4911 Escherichia coli 55989 hypothetical protein YP_002405768.1 5012734 R 585055 CDS YP_002405769.1 218698102 7145235 5012930..5014006 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; Filamentation induced by cAMP protein Fic 5014006 7145235 EC55989_4912 Escherichia coli 55989 Filamentation induced by cAMP protein Fic YP_002405769.1 5012930 D 585055 CDS YP_002405770.1 218698103 7145236 complement(5014057..5014686) 1 NC_011748.1 Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5014686 7145236 EC55989_4913 Escherichia coli 55989 hypothetical protein YP_002405770.1 5014057 R 585055 CDS YP_002405771.1 218698104 7145237 5014728..5015003 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1849492; Product type r : regulator; IS1 repressor protein InsA; KpLE2 phage-like element 5015003 insA 7145237 insA Escherichia coli 55989 IS1 repressor protein InsA; KpLE2 phage-like element YP_002405771.1 5014728 D 585055 CDS YP_002405772.1 218698105 7146579 5014922..5015425 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase ORF B, IS1 5015425 insB 7146579 insB Escherichia coli 55989 transposase ORF B, IS1 YP_002405772.1 5014922 D 585055 CDS YP_002405773.1 218698106 7146590 complement(5015597..5016421) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; Transcriptional regulator 5016421 7146590 EC55989_4916 Escherichia coli 55989 Transcriptional regulator YP_002405773.1 5015597 R 585055 CDS YP_002405774.1 218698107 7145238 5016548..5018143 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1508157; Product type e : enzyme; PTS system, glucose-specific enzyme II, ABC component 5018143 ptsG 7145238 ptsG Escherichia coli 55989 PTS system, glucose-specific enzyme II, ABC component YP_002405774.1 5016548 D 585055 CDS YP_002405775.1 218698108 7147287 5018143..5018832 1 NC_011748.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 5018832 nanE 7147287 nanE Escherichia coli 55989 N-acetylmannosamine-6-phosphate 2-epimerase YP_002405775.1 5018143 D 585055 CDS YP_002405776.1 218698109 7146956 5018893..5019108 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5019108 7146956 EC55989_4919 Escherichia coli 55989 hypothetical protein YP_002405776.1 5018893 D 585055 CDS YP_002405777.1 218698110 7145239 5019087..5019308 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5019308 7145239 EC55989_4920 Escherichia coli 55989 hypothetical protein YP_002405777.1 5019087 D 585055 CDS YP_002405778.1 218698111 7145240 complement(5019316..5019588) 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 5019588 7145240 EC55989_4921 Escherichia coli 55989 hypothetical protein YP_002405778.1 5019316 R 585055 CDS YP_002405779.1 218698112 7145241 5019740..5019898 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 5019898 7145241 EC55989_4922 Escherichia coli 55989 hypothetical protein YP_002405779.1 5019740 D 585055 CDS YP_002405780.1 218698113 7145242 complement(5020393..5020686) 1 NC_011748.1 Evidence 7 : Gene remnant; transposase (fragment), IS110 family 5020686 7145242 EC55989_4923 Escherichia coli 55989 transposase (fragment), IS110 family YP_002405780.1 5020393 R 585055 CDS YP_002405781.1 218698114 7145243 complement(5020729..5020947) 1 NC_011748.1 Evidence 7 : Gene remnant; transposase (fragment), IS110 family 5020947 7145243 EC55989_4924 Escherichia coli 55989 transposase (fragment), IS110 family YP_002405781.1 5020729 R 585055 CDS YP_002405782.1 218698115 7145244 complement(5021078..5022109) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; Transcriptional regulator 5022109 vpeR 7145244 vpeR Escherichia coli 55989 Transcriptional regulator YP_002405782.1 5021078 R 585055 CDS YP_002405783.1 218698116 7147952 5022380..5022823 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; PTS system, specific IIA component 5022823 vpeA 7147952 vpeA Escherichia coli 55989 PTS system, specific IIA component YP_002405783.1 5022380 D 585055 CDS YP_002405784.1 218698117 7147949 5022839..5023126 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; PTS system, specific IIB component 5023126 vpeB 7147949 vpeB Escherichia coli 55989 PTS system, specific IIB component YP_002405784.1 5022839 D 585055 CDS YP_002405785.1 218698118 7147950 5023139..5024395 1 NC_011748.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 5024395 vpeC 7147950 vpeC Escherichia coli 55989 PTS system ascorbate-specific transporter subunit IIC YP_002405785.1 5023139 D 585055 CDS YP_002405786.1 218698119 7147951 complement(5024642..5024896) 1 NC_011748.1 Evidence 7 : Gene remnant; transposase ORF1, IS3 family (fragment) 5024896 7147951 EC55989_4929 Escherichia coli 55989 transposase ORF1, IS3 family (fragment) YP_002405786.1 5024642 R 585055 CDS YP_002405787.1 218698120 7146591 complement(5025318..5026331) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15075407; Product type e : enzyme; Deoxyribose specific mutarotase 5026331 deoM 7146591 deoM Escherichia coli 55989 Deoxyribose specific mutarotase YP_002405787.1 5025318 R 585055 CDS YP_002405788.1 218698121 7145887 complement(5026343..5027659) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 5385522, 15075407, 10648508; Product type pe : enzyme; L-fucose permease 5027659 deoP 7145887 deoP Escherichia coli 55989 L-fucose permease YP_002405788.1 5026343 R 585055 CDS YP_002405789.1 218698122 7145888 complement(5027687..5028634) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10648508, 15385522; Product type e : enzyme; Deoxyribokinase 5028634 deoK 7145888 deoK Escherichia coli 55989 Deoxyribokinase YP_002405789.1 5027687 R 585055 CDS YP_002405790.1 218698123 7145886 5028910..5029695 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15385522, 10648508; Product type pr : regulator; transcriptional regulator 5029695 deoQ 7145886 deoQ Escherichia coli 55989 transcriptional regulator YP_002405790.1 5028910 D 585055 CDS YP_002405791.1 218698124 7146561 complement(5030879..5032492) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; transposase ORF1, IS66 family 5032492 7146561 EC55989_4940 Escherichia coli 55989 transposase ORF1, IS66 family YP_002405791.1 5030879 R 585055 CDS YP_002405792.1 218698125 7145246 complement(5032523..5032873) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; transposase ORF2, IS66 family 5032873 7145246 EC55989_4941 Escherichia coli 55989 transposase ORF2, IS66 family YP_002405792.1 5032523 R 585055 CDS YP_002405793.1 218698126 7145247 complement(5032870..5033295) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; transposase OrfA from plasmid origin 5033295 7145247 EC55989_4942 Escherichia coli 55989 transposase OrfA from plasmid origin YP_002405793.1 5032870 R 585055 CDS YP_002405794.1 218698127 7145248 5033434..5033562 1 NC_011748.1 Evidence 7 : Gene remnant; Product type f : factor; Protein yhdH (fragment) 5033562 7145248 EC55989_4943 Escherichia coli 55989 Protein yhdH (fragment) YP_002405794.1 5033434 D 585055 CDS YP_002405795.1 218698128 7145249 complement(5033743..5034426) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pr : regulator; HTH regulator, TetR family 5034426 7145249 EC55989_4944 Escherichia coli 55989 HTH regulator, TetR family YP_002405795.1 5033743 R 585055 CDS YP_002405796.1 218698129 7145250 complement(5034645..5035937) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5035937 7145250 EC55989_4945 Escherichia coli 55989 hypothetical protein YP_002405796.1 5034645 R 585055 CDS YP_002405797.1 218698130 7145251 complement(5035985..5037988) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702297; Product type t : transporter; betaine-carnitine-choline transporter family member BetU 5037988 7145251 EC55989_4947 Escherichia coli 55989 betaine-carnitine-choline transporter family member BetU YP_002405797.1 5035985 R 585055 CDS YP_002405798.1 218698131 7145252 complement(5038136..5039275) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5039275 7145252 EC55989_4948 Escherichia coli 55989 hypothetical protein YP_002405798.1 5038136 R 585055 CDS YP_002405799.1 218698132 7145253 complement(5039456..5040400) 1 NC_011748.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase 5040400 msbB 7145253 msbB Escherichia coli 55989 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase YP_002405799.1 5039456 R 585055 CDS YP_002405800.1 218698133 7146907 complement(5040465..5041415) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1406277; Product type r : regulator; regulator of virG protein 5041415 virK 7146907 virK Escherichia coli 55989 regulator of virG protein YP_002405800.1 5040465 R 585055 CDS YP_002405801.1 218698134 7147947 complement(5041420..5042508) 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Glycosyl transferase 5042508 7147947 EC55989_4951 Escherichia coli 55989 Glycosyl transferase YP_002405801.1 5041420 R 585055 CDS YP_002405802.1 218698135 7145254 complement(5042511..5043332) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; polysaccharide deacetylase 5043332 shf 7145254 shf Escherichia coli 55989 polysaccharide deacetylase YP_002405802.1 5042511 R 585055 CDS YP_002405803.1 218698136 7147652 5043497..5043841 1 NC_011748.1 Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase ORF A, IS911 5043841 7147652 EC55989_4953 Escherichia coli 55989 transposase ORF A, IS911 YP_002405803.1 5043497 D 585055 CDS YP_002405804.1 218698137 7146600 5044914..5046437 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; reverse transcriptase-like protein from prophage or plasmid 5046437 7146600 EC55989_4955 Escherichia coli 55989 reverse transcriptase-like protein from prophage or plasmid YP_002405804.1 5044914 D 585055 CDS YP_002405805.1 218698138 7145257 5046932..5047345 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; KpLE2 phage-like element 5047345 yjhV 7145257 yjhV Escherichia coli 55989 KpLE2 phage-like element YP_002405805.1 5046932 D 585055 CDS YP_002405806.1 218698139 7149206 complement(5047903..5048670) 1 NC_011748.1 Part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter ATP-binding subunit 5048670 fecE 7149206 fecE Escherichia coli 55989 iron-dicitrate transporter ATP-binding subunit YP_002405806.1 5047903 R 585055 CDS YP_002405807.1 218698140 7146083 5048474..5048638 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5048638 7146083 EC55989_4960 Escherichia coli 55989 hypothetical protein YP_002405807.1 5048474 D 585055 CDS YP_002405808.1 218698141 7145258 complement(5048671..5049627) 1 NC_011748.1 Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter.; iron-dicitrate transporter subunit FecD 5049627 fecD 7145258 fecD Escherichia coli 55989 iron-dicitrate transporter subunit FecD YP_002405808.1 5048671 R 585055 CDS YP_002405809.1 218698142 7146082 complement(5049624..5050622) 1 NC_011748.1 part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter permease subunit 5050622 fecC 7146082 fecC Escherichia coli 55989 iron-dicitrate transporter permease subunit YP_002405809.1 5049624 R 585055 CDS YP_002405810.1 218698143 7146081 complement(5050619..5051521) 1 NC_011748.1 part of the ABC transporter involved in the uptake of citrate-dependent Fe(3+); iron-dicitrate transporter substrate-binding subunit 5051521 fecB 7146081 fecB Escherichia coli 55989 iron-dicitrate transporter substrate-binding subunit YP_002405810.1 5050619 R 585055 CDS YP_002405811.1 218698144 7146080 complement(5051566..5053890) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90105402, 91072220, 92269759, 2836368; Product type t : transporter; ferric citrate outer membrane transporter; KpLE2 phage-like element 5053890 fecA 7146080 fecA Escherichia coli 55989 ferric citrate outer membrane transporter; KpLE2 phage-like element YP_002405811.1 5051566 R 585055 CDS YP_002405812.1 218698145 7146079 complement(5053977..5054930) 1 NC_011748.1 with FecA forms the FecAR signal transduction system; ferric citrate binds FecA and transmits a signal across the outer membrane to FecR. FecR transmits a signal across the cytoplasmic membrane and activates the sigma 70 protein FecI that directs the RNA polymerase to express the fecABCDE operon; fec operon regulator FecR 5054930 fecR 7146079 fecR Escherichia coli 55989 fec operon regulator FecR YP_002405812.1 5053977 R 585055 CDS YP_002405813.1 218698146 7146085 complement(5054927..5055448) 1 NC_011748.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport; RNA polymerase sigma factor FecI 5055448 fecI 7146085 fecI Escherichia coli 55989 RNA polymerase sigma factor FecI YP_002405813.1 5054927 R 585055 CDS YP_002405814.1 218698147 7146084 complement(5056786..5056995) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5056995 7146084 EC55989_4968 Escherichia coli 55989 hypothetical protein YP_002405814.1 5056786 R 585055 CDS YP_002405815.1 218698148 7145259 5057359..5058732 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5058732 7145259 EC55989_4969 Escherichia coli 55989 hypothetical protein YP_002405815.1 5057359 D 585055 CDS YP_002405816.1 218698149 7145260 complement(5058971..5060356) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; transposase 5060356 7145260 EC55989_4970 Escherichia coli 55989 transposase YP_002405816.1 5058971 R 585055 CDS YP_002405817.1 218698150 7145261 complement(5060406..5060753) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; transposase ORF2, IS66 family 5060753 7145261 EC55989_4971 Escherichia coli 55989 transposase ORF2, IS66 family YP_002405817.1 5060406 R 585055 CDS YP_002405818.1 218698151 7145262 complement(5060750..5061151) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; transposase, IS3 family 5061151 7145262 EC55989_4972 Escherichia coli 55989 transposase, IS3 family YP_002405818.1 5060750 R 585055 CDS YP_002405819.1 218698152 7145263 complement(5061485..5062006) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5062006 7145263 EC55989_4973 Escherichia coli 55989 hypothetical protein YP_002405819.1 5061485 R 585055 CDS YP_002405820.1 218698153 7145264 complement(5061907..5062314) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5062314 7145264 EC55989_4974 Escherichia coli 55989 hypothetical protein YP_002405820.1 5061907 R 585055 CDS YP_002405821.1 218698154 7145265 complement(5062568..5063173) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5063173 7145265 EC55989_4975 Escherichia coli 55989 hypothetical protein YP_002405821.1 5062568 R 585055 CDS YP_002405822.1 218698155 7145266 complement(5063878..5064054) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 5064054 7145266 EC55989_4976 Escherichia coli 55989 transcriptional regulator YP_002405822.1 5063878 R 585055 CDS YP_002405823.1 218698156 7145267 complement(5064355..5064621) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5064621 7145267 EC55989_4977 Escherichia coli 55989 hypothetical protein YP_002405823.1 5064355 R 585055 CDS YP_002405824.1 218698157 7145268 5064567..5064968 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5064968 7145268 EC55989_4978 Escherichia coli 55989 hypothetical protein YP_002405824.1 5064567 D 585055 CDS YP_002405825.1 218698158 7145269 5065048..5065665 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5065665 7145269 EC55989_4979 Escherichia coli 55989 hypothetical protein YP_002405825.1 5065048 D 585055 CDS YP_002405826.1 218698159 7145270 5065837..5066034 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5066034 7145270 EC55989_4980 Escherichia coli 55989 hypothetical protein YP_002405826.1 5065837 D 585055 CDS YP_002405827.1 218698160 7145271 5066866..5067543 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5067543 7145271 EC55989_4981 Escherichia coli 55989 hypothetical protein YP_002405827.1 5066866 D 585055 CDS YP_002405828.1 218698161 7145272 complement(5067554..5068057) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 273224, 375010, 1849492; Product type pe : enzyme; Insertion element IS1 1/5/6 protein InsB 5068057 7145272 EC55989_4982 Escherichia coli 55989 Insertion element IS1 1/5/6 protein InsB YP_002405828.1 5067554 R 585055 CDS YP_002405829.1 218698162 7145273 complement(5067976..5068251) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1849492; Product type r : regulator; IS1 repressor protein insA 5068251 7145273 EC55989_4983 Escherichia coli 55989 IS1 repressor protein insA YP_002405829.1 5067976 R 585055 CDS YP_002405830.1 218698163 7146111 complement(5068650..5069993) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125229, 15516583, 8550444; Product type t : transporter; fructuronate transporter 5069993 gntP 7146111 gntP Escherichia coli 55989 fructuronate transporter YP_002405830.1 5068650 R 585055 CDS YP_002405831.1 218698164 7146350 5070073..5070381 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 5070381 7146350 EC55989_4986 Escherichia coli 55989 hypothetical protein YP_002405831.1 5070073 D 585055 CDS YP_002405832.1 218698165 7145275 5070333..5071517 1 NC_011748.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 5071517 uxuA 7145275 uxuA Escherichia coli 55989 mannonate dehydratase YP_002405832.1 5070333 D 585055 CDS YP_002405833.1 218698166 7147941 5071598..5073058 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73203083, 77222076, 14401695; Product type e : enzyme; D-mannonate oxidoreductase, NAD-binding 5073058 uxuB 7147941 uxuB Escherichia coli 55989 D-mannonate oxidoreductase, NAD-binding YP_002405833.1 5071598 D 585055 CDS YP_002405834.1 218698167 7147942 5073273..5074046 1 NC_011748.1 regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 5074046 uxuR 7147942 uxuR Escherichia coli 55989 DNA-binding transcriptional repressor UxuR YP_002405834.1 5073273 D 585055 CDS YP_002405835.1 218698168 7147943 complement(5074187..5075017) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5075017 yjiC 7147943 yjiC Escherichia coli 55989 hypothetical protein YP_002405835.1 5074187 R 585055 CDS YP_002405836.1 218698169 7149208 5075580..5075723 1 NC_011748.1 Evidence 6 : Doubtful CDS; hypothetical protein 5075723 7149208 EC55989_4991 Escherichia coli 55989 hypothetical protein YP_002405836.1 5075580 D 585055 CDS YP_002405837.1 218698170 7145276 5075689..5076081 1 NC_011748.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 5076081 iraD 7145276 iraD Escherichia coli 55989 DNA replication/recombination/repair protein YP_002405837.1 5075689 D 585055 CDS YP_002405838.1 218698171 7149209 complement(5076074..5076985) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 5076985 yjiE 7149209 yjiE Escherichia coli 55989 DNA-binding transcriptional regulator YP_002405838.1 5076074 R 585055 CDS YP_002405839.1 218698172 7149210 complement(5077050..5078222) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95181377, 7876157; Product type e : enzyme; isoaspartyl dipeptidase 5078222 iadA 7149210 iadA Escherichia coli 55989 isoaspartyl dipeptidase YP_002405839.1 5077050 R 585055 CDS YP_002405840.1 218698173 7146529 complement(5078235..5078696) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 5078696 yjiG 7146529 yjiG Escherichia coli 55989 hypothetical protein YP_002405840.1 5078235 R 585055 CDS YP_002405841.1 218698174 7149211 complement(5078693..5079376) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 5079376 yjiH 7149211 yjiH Escherichia coli 55989 inner membrane protein YP_002405841.1 5078693 R 585055 CDS YP_002405842.1 218698175 7149212 5079626..5080180 1 NC_011748.1 in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown; RNA 2'-phosphotransferase-like protein 5080180 kptA 7149212 kptA Escherichia coli 55989 RNA 2'-phosphotransferase-like protein YP_002405842.1 5079626 D 585055 CDS YP_002405843.1 218698176 7146672 complement(5080193..5081371) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 5081371 yjiJ 7146672 yjiJ Escherichia coli 55989 inner membrane protein YP_002405843.1 5080193 R 585055 CDS YP_002405844.1 218698177 7149213 complement(5081439..5082299) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 5082299 yjiK 7149213 yjiK Escherichia coli 55989 hypothetical protein YP_002405844.1 5081439 R 585055 CDS YP_002405845.1 218698178 7149214 complement(5082364..5082621) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5082621 7149214 EC55989_5000 Escherichia coli 55989 hypothetical protein YP_002405845.1 5082364 R 585055 CDS YP_002405846.1 218698179 7145277 complement(5082618..5083385) 1 NC_011748.1 Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8365476, 7607244, 15654892; Product type e : enzyme; ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase 5083385 hgdC 7145277 hgdC Escherichia coli 55989 ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase YP_002405846.1 5082618 R 585055 CDS YP_002405847.1 218698180 7146425 complement(5083395..5084546) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3691501, 11106419; Product type pe : enzyme; 2-hydroxyglutaryl-CoA dehydratase 5084546 yjiM 7146425 yjiM Escherichia coli 55989 2-hydroxyglutaryl-CoA dehydratase YP_002405847.1 5083395 R 585055 CDS YP_002405848.1 218698181 7149215 complement(5084662..5085942) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 5085942 yjiN 7149215 yjiN Escherichia coli 55989 inner membrane protein YP_002405848.1 5084662 R 585055 CDS YP_002405849.1 218698182 7149216 complement(5085983..5087215) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803; Product type t : transporter; multidrug efflux system protein 5087215 yjiO 7149216 yjiO Escherichia coli 55989 multidrug efflux system protein YP_002405849.1 5085983 R 585055 CDS YP_002405850.1 218698183 7149217 5087682..5088638 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; transposase 5088638 7149217 EC55989_5005 Escherichia coli 55989 transposase YP_002405850.1 5087682 D 585055 CDS YP_002405851.1 218698184 7145278 complement(5088881..5090293) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; fused DNA-binding transcriptional regulator ; aminotransferase 5090293 yjiR 7145278 yjiR Escherichia coli 55989 fused DNA-binding transcriptional regulator ; aminotransferase YP_002405851.1 5088881 R 585055 CDS YP_002405852.1 218698185 7145280 complement(5092871..5093212) 1 NC_011748.1 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE 5093212 yjiW 7145280 yjiW Escherichia coli 55989 endoribonuclease SymE YP_002405852.1 5092871 R 585055 CDS YP_002405853.1 218698186 7147595 complement(5093433..5095169) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9837717, 10733903, 11273713; Product type f : factor; Type I restriction enzyme EcoAI specificity protein (S protein) (S.EcoAI) 5095169 7147595 EC55989_5010 Escherichia coli 55989 Type I restriction enzyme EcoAI specificity protein (S protein) (S.EcoAI) YP_002405853.1 5093433 R 585055 CDS YP_002405854.1 218698187 7145281 complement(5095169..5096674) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8412658, 1409708; Product type e : enzyme; Type I restriction enzyme EcoEI M protein (M.EcoEI) 5096674 hsdM 7145281 hsdM Escherichia coli 55989 Type I restriction enzyme EcoEI M protein (M.EcoEI) YP_002405854.1 5095169 R 585055 CDS YP_002405855.1 218698188 7146465 complement(5096705..5099137) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9837717, 10373579, 10733903, 8412658; Product type e : enzyme; Type I restriction enzyme EcoAI R protein (R.EcoAI) 5099137 hsdR 7146465 hsdR Escherichia coli 55989 Type I restriction enzyme EcoAI R protein (R.EcoAI) YP_002405855.1 5096705 R 585055 CDS YP_002405856.1 218698189 7146466 5099394..5101067 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5101067 7146466 EC55989_5013 Escherichia coli 55989 hypothetical protein YP_002405856.1 5099394 D 585055 CDS YP_002405857.1 218698190 7145282 complement(5101136..5102092) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14696199; Product type pe : enzyme; GTP-binding protein YjiA 5102092 yjiA 7145282 yjiA Escherichia coli 55989 GTP-binding protein YjiA YP_002405857.1 5101136 R 585055 CDS YP_002405858.1 218698191 7149207 complement(5102103..5102432) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5102432 7149207 EC55989_5015 Escherichia coli 55989 hypothetical protein YP_002405858.1 5102103 R 585055 CDS YP_002405859.1 218698192 7145283 complement(5102437..5104587) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 5104587 yjiY 7145283 yjiY Escherichia coli 55989 inner membrane protein YP_002405859.1 5102437 R 585055 CDS YP_002405860.1 218698193 7149220 5104964..5106628 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 89034150, 91317710, 10466731, 2033064, 6213619, 6402709, 8384293; Product type r : regulator; methyl-accepting chemotaxis protein I, serine sensor receptor 5106628 tsr 7149220 tsr Escherichia coli 55989 methyl-accepting chemotaxis protein I, serine sensor receptor YP_002405860.1 5104964 D 585055 CDS YP_002405861.1 218698194 7147867 complement(5106677..5108038) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 5108038 yjiZ 7147867 yjiZ Escherichia coli 55989 transporter YP_002405861.1 5106677 R 585055 CDS YP_002405862.1 218698195 7149221 complement(5108253..5109167) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 5109167 yjjM 7149221 yjjM Escherichia coli 55989 DNA-binding transcriptional regulator YP_002405862.1 5108253 R 585055 CDS YP_002405863.1 218698196 7149226 5109306..5110328 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase, Zn-dependent and NAD(P)-binding 5110328 yjjN 7149226 yjjN Escherichia coli 55989 oxidoreductase, Zn-dependent and NAD(P)-binding YP_002405863.1 5109306 D 585055 CDS YP_002405864.1 218698197 7149227 complement(5110469..5112760) 1 NC_011748.1 catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I 5112760 mdoB 7149227 mdoB Escherichia coli 55989 phosphoglycerol transferase I YP_002405864.1 5110469 R 585055 CDS YP_002405865.1 218698198 7146797 complement(5113014..5113508) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5113508 yjjA 7146797 yjjA Escherichia coli 55989 hypothetical protein YP_002405865.1 5113014 R 585055 CDS YP_002405866.1 218698199 7149222 complement(5113557..5114294) 1 NC_011748.1 acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC 5114294 dnaC 7149222 dnaC Escherichia coli 55989 DNA replication protein DnaC YP_002405866.1 5113557 R 585055 CDS YP_002405867.1 218698200 7145934 complement(5114297..5114836) 1 NC_011748.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI 5114836 dnaT 7145934 dnaT Escherichia coli 55989 primosomal protein DnaI YP_002405867.1 5114297 R 585055 CDS YP_002405868.2 229598871 7145941 complement(5114943..5115416) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5115416 7145941 EC55989_5025 Escherichia coli 55989 hypothetical protein YP_002405868.2 5114943 R 585055 CDS YP_002405869.1 218698202 7145284 complement(5115407..5116177) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 5116177 yjjP 7145284 yjjP Escherichia coli 55989 inner membrane protein YP_002405869.1 5115407 R 585055 CDS YP_002405870.1 218698203 7149228 5116798..5117523 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 5117523 yjjQ 7149228 yjjQ Escherichia coli 55989 DNA-binding transcriptional regulator YP_002405870.1 5116798 D 585055 CDS YP_002405871.1 218698204 7149229 5117535..5118158 1 NC_011748.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 5118158 bglJ 7149229 bglJ Escherichia coli 55989 DNA-binding transcriptional activator BglJ YP_002405871.1 5117535 D 585055 CDS YP_002405872.1 218698205 7145622 complement(5118196..5118984) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11931550, 14756576, 3323834, 9990318; Product type c : carrier; ferric hydroximate transport ferric iron reductase 5118984 fhuF 7145622 fhuF Escherichia coli 55989 ferric hydroximate transport ferric iron reductase YP_002405872.1 5118196 R 585055 CDS YP_002405873.1 218698206 7146104 5119014..5119361 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5119361 7146104 EC55989_5030 Escherichia coli 55989 hypothetical protein YP_002405873.1 5119014 D 585055 CDS YP_002405874.1 218698207 7145368 complement(5120031..5121062) 1 NC_011748.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase 5121062 rsmC 7145368 rsmC Escherichia coli 55989 16S ribosomal RNA m2G1207 methyltransferase YP_002405874.1 5120031 R 585055 CDS YP_002405875.1 218698208 7147536 5121165..5121578 1 NC_011748.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 5121578 holD 7147536 holD Escherichia coli 55989 DNA polymerase III subunit psi YP_002405875.1 5121165 D 585055 CDS YP_002405876.1 218698209 7146456 5121547..5121993 1 NC_011748.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 5121993 rimI 7146456 rimI Escherichia coli 55989 ribosomal-protein-alanine N-acetyltransferase YP_002405876.1 5121547 D 585055 CDS YP_002405877.1 218698210 7147418 5122008..5122685 1 NC_011748.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 5122685 yjjG 7147418 yjjG Escherichia coli 55989 nucleotidase YP_002405877.1 5122008 D 585055 CDS YP_002405878.1 218698211 7149223 5122776..5124365 1 NC_011748.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 5124365 prfC 7149223 prfC Escherichia coli 55989 peptide chain release factor 3 YP_002405878.1 5122776 D 585055 CDS YP_002405879.1 218698212 7147242 5124758..5125363 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1317380, 8253679, 9298646, 9600841; Product type cp : cell process; hypothetical protein 5125363 osmY 7147242 osmY Escherichia coli 55989 hypothetical protein YP_002405879.1 5124758 D 585055 CDS YP_002405880.1 218698213 7147084 5125472..5125651 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5125651 ytjA 7147084 ytjA Escherichia coli 55989 hypothetical protein YP_002405880.1 5125472 D 585055 CDS YP_002405881.1 218698214 7149483 5125773..5126846 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; esterase 5126846 yjjU 7149483 yjjU Escherichia coli 55989 esterase YP_002405881.1 5125773 D 585055 CDS YP_002405882.1 218698215 7149230 5126843..5127625 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; deoxyribonuclease YjjV 5127625 yjjV 7149230 yjjV Escherichia coli 55989 deoxyribonuclease YjjV YP_002405882.1 5126843 D 585055 CDS YP_002405883.1 218698216 7149231 complement(5127855..5128718) 1 NC_011748.1 Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; pyruvate formate lyase activating enzyme 5128718 yjjW 7149231 yjjW Escherichia coli 55989 pyruvate formate lyase activating enzyme YP_002405883.1 5127855 R 585055 CDS YP_002405884.1 218698217 7149232 complement(5128690..5130240) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5130240 yjjI 7149232 yjjI Escherichia coli 55989 hypothetical protein YP_002405884.1 5128690 R 585055 CDS YP_002405885.1 218698218 7149224 5130498..5131277 1 NC_011748.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 5131277 deoC 7149224 deoC Escherichia coli 55989 deoxyribose-phosphate aldolase YP_002405885.1 5130498 D 585055 CDS YP_002405886.1 218698219 7145884 5131355..5132677 1 NC_011748.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 5132677 deoA 7145884 deoA Escherichia coli 55989 thymidine phosphorylase YP_002405886.1 5131355 D 585055 CDS YP_002405887.1 218698220 7145882 5132729..5133952 1 NC_011748.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 5133952 deoB 7145882 deoB Escherichia coli 55989 phosphopentomutase YP_002405887.1 5132729 D 585055 CDS YP_002405888.1 218698221 7145883 5134032..5134751 1 NC_011748.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 5134751 deoD 7145883 deoD Escherichia coli 55989 purine nucleoside phosphorylase YP_002405888.1 5134032 D 585055 CDS YP_002405889.1 218698222 7145286 complement(5135207..5136223) 1 NC_011748.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A 5136223 lplA 7145286 lplA Escherichia coli 55989 lipoate-protein ligase A YP_002405889.1 5135207 R 585055 CDS YP_002405890.1 218698223 7146731 complement(5136251..5136895) 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2684780; hypothetical protein 5136895 ytjB 7146731 ytjB Escherichia coli 55989 hypothetical protein YP_002405890.1 5136251 R 585055 CDS YP_002405891.1 218698224 7149484 5137001..5137969 1 NC_011748.1 catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 5137969 serB 7149484 serB Escherichia coli 55989 phosphoserine phosphatase YP_002405891.1 5137001 D 585055 CDS YP_002405892.1 218698225 7147633 5138018..5139400 1 NC_011748.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 5139400 radA 7147633 radA Escherichia coli 55989 DNA repair protein RadA YP_002405892.1 5138018 D 585055 CDS YP_002405893.1 218698226 7147335 5139421..5140653 1 NC_011748.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 5140653 nadR 7147335 nadR Escherichia coli 55989 nicotinamide-nucleotide adenylyltransferase YP_002405893.1 5139421 D 585055 CDS YP_002405894.1 218698227 7146947 complement(5140960..5142627) 1 NC_011748.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein 5142627 yjjK 7146947 yjjK Escherichia coli 55989 ABC transporter ATP-binding protein YP_002405894.1 5140960 R 585055 CDS YP_002405895.1 218698228 7149225 5142838..5144775 1 NC_011748.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 5144775 slt 7149225 slt Escherichia coli 55989 lytic murein transglycosylase YP_002405895.1 5142838 D 585055 CDS YP_002405896.1 218698229 7147661 5144865..5145191 1 NC_011748.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 5145191 trpR 7147661 trpR Escherichia coli 55989 Trp operon repressor YP_002405896.1 5144865 D 585055 CDS YP_002405897.1 218698230 7147856 complement(5145233..5145745) 1 NC_011748.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase 5145745 yjjX 7147856 yjjX Escherichia coli 55989 NTPase YP_002405897.1 5145233 R 585055 CDS YP_002405898.1 218698231 7149233 5145797..5146444 1 NC_011748.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 5146444 ytjC 7149233 ytjC Escherichia coli 55989 phosphoglycerate mutase YP_002405898.1 5145797 D 585055 CDS YP_002405899.1 218698232 7149485 complement(5146441..5147310) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20264525, 20309711, 93194823, 96405618, 8449900; Product type r : regulator; DNA-binding transcriptional activator 5147310 rob 7149485 rob Escherichia coli 55989 DNA-binding transcriptional activator YP_002405899.1 5146441 R 585055 CDS YP_002405900.1 218698233 7147457 5147521..5147994 1 NC_011748.1 Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3531171, 8449900; hypothetical protein 5147994 creA 7147457 creA Escherichia coli 55989 hypothetical protein YP_002405900.1 5147521 D 585055 CDS YP_002405901.1 218698234 7145753 5148007..5148696 1 NC_011748.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 5148696 creB 7145753 creB Escherichia coli 55989 DNA-binding response regulator CreB YP_002405901.1 5148007 D 585055 CDS YP_002405902.1 218698235 7145754 5148696..5150120 1 NC_011748.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 5150120 creC 7145754 creC Escherichia coli 55989 sensory histidine kinase CreC YP_002405902.1 5148696 D 585055 CDS YP_002405903.1 218698236 7145755 5150178..5151530 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88216172, 2835585, 2984198, 3531171; Product type m : membrane component; hypothetical protein 5151530 creD 7145755 creD Escherichia coli 55989 hypothetical protein YP_002405903.1 5150178 D 585055 CDS YP_002405904.1 218698237 7145756 complement(5151590..5152306) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15028693, 21167794, 21317451, 91008980, 91358353, 92380937, 9514749, 9632255, 2984198, 7565118, 9298646; Product type r : regulator; two-component response regulator 5152306 arcA 7145756 arcA Escherichia coli 55989 two-component response regulator YP_002405904.1 5151590 R 585055 CDS YP_002405905.1 218698238 7145522 complement(5152427..5153578) 1 NC_011748.1 Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094, 6092059; Product type e : enzyme; IS30 transposase; KpLE2 phage-like element 5153578 insI 7145522 insI Escherichia coli 55989 IS30 transposase; KpLE2 phage-like element YP_002405905.1 5152427 R 585055 CDS YP_002405906.1 218698239 7147433 5154165..5154851 1 NC_011748.1 member of the SPOUT superfamily of methyltransferases; RNA methyltransferase 5154851 yjtD 7147433 yjtD Escherichia coli 55989 RNA methyltransferase YP_002405906.1 5154165 D 585055 CDS