-- dump date 20140619_080758 -- class Genbank::Feature -- table feature -- table main -- field 1 id -- field 2 type -- field 3 name -- field 4 contig -- field 5 start_pos -- field 6 end_pos -- field 7 strand -- field 8 description -- field 9 chrom_position -- field 10 organism -- field 11 GeneID -- header -- id type name contig start_pos end_pos strand description chrom_position organism GeneID 585055000001 SEQ_END SEQ_END NC_011748.1 5154862 5154862 DR NC_011748.1; contig end 5154862..5154862 Escherichia coli 55989 YP_002401144.1 CDS thrL NC_011748.1 203 268 D involved in threonine biosynthesis; controls the expression of the thrLABC operon; thr operon leader peptide 203..268 Escherichia coli 55989 7149501 YP_002401145.1 CDS thrA NC_011748.1 349 2811 D multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartokinase I/homoserine dehydrogenase I 349..2811 Escherichia coli 55989 7147797 YP_002401146.1 CDS thrB NC_011748.1 2813 3745 D catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate; homoserine kinase 2813..3745 Escherichia coli 55989 7147794 YP_002401147.1 CDS thrC NC_011748.1 3746 5032 D catalyzes the formation of L-threonine from O-phospho-L-homoserine; threonine synthase 3746..5032 Escherichia coli 55989 7147795 YP_002401148.1 CDS yaaX NC_011748.1 5246 5542 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5246..5542 Escherichia coli 55989 7147796 YP_002401149.1 CDS yaaA NC_011748.1 5695 6471 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5695..6471) Escherichia coli 55989 7148007 YP_002401150.1 CDS yaaJ NC_011748.1 6541 7971 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; amino acid sodium/proton transporter complement(6541..7971) Escherichia coli 55989 7148002 YP_002401151.1 CDS talB NC_011748.1 8250 9203 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 92334977, 11298760, 7592346, 8805555, 9007983, 9298646; Product type e : enzyme; transaldolase B 8250..9203 Escherichia coli 55989 7148005 YP_002401152.1 CDS mogA NC_011748.1 9318 9905 D forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MogA 9318..9905 Escherichia coli 55989 7147748 YP_002401153.1 CDS yaaH NC_011748.1 9940 10506 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(9940..10506) Escherichia coli 55989 7146886 YP_002401154.1 CDS htpY NC_011748.1 10655 11368 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8478327; Product type r : regulator; hypothetical protein complement(10655..11368) Escherichia coli 55989 7148003 YP_002401155.1 CDS yaaI NC_011748.1 11394 11798 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(11394..11798) Escherichia coli 55989 7146475 YP_002401156.1 CDS dnaK NC_011748.1 12175 14091 D heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria; molecular chaperone DnaK 12175..14091 Escherichia coli 55989 7148004 YP_002401157.1 CDS dnaJ NC_011748.1 14180 15310 D chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion; molecular chaperone DnaJ 14180..15310 Escherichia coli 55989 7147831 YP_002401158.1 CDS nhaA NC_011748.1 16152 17318 D exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH; pH-dependent sodium/proton antiporter 16152..17318 Escherichia coli 55989 7147677 YP_002401159.1 CDS nhaR NC_011748.1 17378 18283 D Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC; transcriptional activator NhaR 17378..18283 Escherichia coli 55989 7146991 YP_002401160.1 CDS EC55989_0018 NC_011748.1 18322 19281 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(18322..19281) Escherichia coli 55989 7146993 YP_002401161.1 CDS rpsT NC_011748.1 22776 23039 R binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase; 30S ribosomal protein S20 complement(22776..23039) Escherichia coli 55989 7144359 YP_002401162.1 CDS yaaY NC_011748.1 23142 23360 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 23142..23360 Escherichia coli 55989 7147524 YP_002401163.1 CDS ribF NC_011748.1 23368 24309 D catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities; bifunctional riboflavin kinase/FMN adenylyltransferase 23368..24309 Escherichia coli 55989 7148008 YP_002401164.1 CDS ileS NC_011748.1 24352 27168 D IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme; isoleucyl-tRNA synthetase 24352..27168 Escherichia coli 55989 7147414 YP_002401165.1 CDS lspA NC_011748.1 27168 27662 D lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis; lipoprotein signal peptidase 27168..27662 Escherichia coli 55989 7146548 YP_002401166.1 CDS fkpB NC_011748.1 27750 28199 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97332650, 2011499; Product type e : enzyme; FKBP-type peptidylprolyl isomerase 27750..28199 Escherichia coli 55989 7146745 YP_002401167.1 CDS ispH NC_011748.1 28201 29151 D catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway; 4-hydroxy-3-methylbut-2-enyl diphosphate reductase 28201..29151 Escherichia coli 55989 7146121 YP_002401168.1 CDS rihC NC_011748.1 29217 30131 D catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides; ribonucleoside hydrolase RihC 29217..30131 Escherichia coli 55989 7146631 YP_002401169.1 CDS dapB NC_011748.1 30298 31119 D catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate reductase 30298..31119 Escherichia coli 55989 7147417 YP_002401170.1 CDS carA NC_011748.1 31575 32723 D catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers; carbamoyl phosphate synthase small subunit 31575..32723 Escherichia coli 55989 7145850 YP_002401171.1 CDS carB NC_011748.1 32741 35962 D four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity; carbamoyl phosphate synthase large subunit 32741..35962 Escherichia coli 55989 7145664 YP_002401172.1 CDS EC55989_0033 NC_011748.1 35970 36188 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7815937, 6308632; hypothetical protein complement(35970..36188) Escherichia coli 55989 7145665 YP_002401173.1 CDS caiF NC_011748.1 36223 36618 D regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons; DNA-binding transcriptional activator CaiF 36223..36618 Escherichia coli 55989 7144360 YP_002401174.1 CDS caiE NC_011748.1 36704 37294 R involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities; carnitine operon protein CaiE complement(36704..37294) Escherichia coli 55989 7145661 YP_002401175.2 CDS caiD NC_011748.1 37300 38085 R catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA; carnitinyl-CoA dehydratase complement(37300..38085) Escherichia coli 55989 7145660 YP_002401176.1 CDS caiC NC_011748.1 38194 39762 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15731894, 97189569, 7815937; Product type e : enzyme; crotonobetaine/carnitine-CoA ligase complement(38194..39762) Escherichia coli 55989 7145659 YP_002401177.1 CDS caiB NC_011748.1 39821 41038 R catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine; crotonobetainyl-CoA:carnitine CoA-transferase complement(39821..41038) Escherichia coli 55989 7145658 YP_002401178.1 CDS caiA NC_011748.1 41167 42309 R catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA; crotonobetainyl-CoA dehydrogenase complement(41167..42309) Escherichia coli 55989 7145657 YP_002401179.1 CDS caiT NC_011748.1 42340 43854 R catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism; L-carnitine/gamma-butyrobetaine antiporter complement(42340..43854) Escherichia coli 55989 7145656 YP_002401180.1 CDS fixA NC_011748.1 44328 45098 D required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase; electron transfer flavoprotein FixA 44328..45098 Escherichia coli 55989 7145662 YP_002401181.1 CDS fixB NC_011748.1 45113 46054 D involved in electron transfer during carnitine metabolism; electron transfer flavoprotein FixB 45113..46054 Escherichia coli 55989 7146115 YP_002401182.1 CDS fixC NC_011748.1 46105 47391 D FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction; oxidoreductase FixC 46105..47391 Escherichia coli 55989 7146116 YP_002401183.1 CDS fixX NC_011748.1 47388 47675 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96066354, 12081978; Product type pc : carrier; 4Fe-4S ferredoxin 47388..47675 Escherichia coli 55989 7146117 YP_002401184.1 CDS yaaU NC_011748.1 47734 49065 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 47734..49065 Escherichia coli 55989 7146118 YP_002401185.1 CDS kefF NC_011748.1 49173 49703 D Required for full activity of KefC, a potassium-proton antiporter; glutathione-regulated potassium-efflux system ancillary protein KefF 49173..49703 Escherichia coli 55989 7148006 YP_002401186.1 CDS kefC NC_011748.1 49696 51558 D transport system that facilitates potassium-efflux; glutathione-regulated potassium-efflux system protein KefC 49696..51558 Escherichia coli 55989 7146669 YP_002401187.1 CDS folA NC_011748.1 51750 52229 D catalyzes the reduction of dihydrofolate to tetrahydrofolate; dihydrofolate reductase 51750..52229 Escherichia coli 55989 7146668 YP_002401188.1 CDS apaH NC_011748.1 52307 53149 R hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP; diadenosine tetraphosphatase complement(52307..53149) Escherichia coli 55989 7146168 YP_002401189.1 CDS apaG NC_011748.1 53156 53533 R protein associated with Co2+ and Mg2+ efflux; ApaG protein complement(53156..53533) Escherichia coli 55989 7145506 YP_002401190.1 CDS ksgA NC_011748.1 53536 54357 R catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin; dimethyladenosine transferase complement(53536..54357) Escherichia coli 55989 7145505 YP_002401191.1 CDS pdxA NC_011748.1 54354 55343 R catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate); 4-hydroxythreonine-4-phosphate dehydrogenase complement(54354..55343) Escherichia coli 55989 7146673 YP_002401192.1 CDS surA NC_011748.1 55343 56629 R Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB; peptidyl-prolyl cis-trans isomerase SurA complement(55343..56629) Escherichia coli 55989 7147124 YP_002401193.1 CDS imp NC_011748.1 56682 59036 R determines N-hexane tolerance and is involved in outer membrane permeability; organic solvent tolerance protein complement(56682..59036) Escherichia coli 55989 7147740 YP_002401194.1 CDS djlA NC_011748.1 59291 60106 D functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system; Dna-J like membrane chaperone protein 59291..60106 Escherichia coli 55989 7146563 YP_002401195.1 CDS rluA NC_011748.1 60223 60882 R catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs; 23S rRNA/tRNA pseudouridine synthase A complement(60223..60882) Escherichia coli 55989 7145921 YP_002401196.1 CDS hepA NC_011748.1 60894 63800 R transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA; ATP-dependent helicase HepA complement(60894..63800) Escherichia coli 55989 7147426 YP_002401197.1 CDS polB NC_011748.1 63965 66316 R Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C; DNA polymerase II complement(63965..66316) Escherichia coli 55989 7146419 YP_002401198.1 CDS araD NC_011748.1 66391 67086 R catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase complement(66391..67086) Escherichia coli 55989 7147208 YP_002401199.1 CDS araA NC_011748.1 67255 68757 R catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism; L-arabinose isomerase complement(67255..68757) Escherichia coli 55989 7145516 YP_002401200.1 CDS araB NC_011748.1 68768 70468 R catalyzes the phosphorylation of ribulose to ribulose 5-phosphate; ribulokinase complement(68768..70468) Escherichia coli 55989 7145513 YP_002401201.1 CDS araC NC_011748.1 70807 71685 D positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose; DNA-binding transcriptional regulator AraC 70807..71685 Escherichia coli 55989 7145514 YP_002401202.1 CDS yabI NC_011748.1 71771 72535 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 71771..72535 Escherichia coli 55989 7145515 YP_002401203.1 CDS thiQ NC_011748.1 72649 73347 R with TbpA and ThiP is part of the thiamine and TPP transport system; thiamine transporter ATP-binding subunit complement(72649..73347) Escherichia coli 55989 7148009 YP_002401204.1 CDS thiP NC_011748.1 73331 74941 R permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine; thiamine transporter membrane protein complement(73331..74941) Escherichia coli 55989 7147792 YP_002401205.1 CDS tbpA NC_011748.1 74917 75900 R part of the thiamine and TPP transport system tbpA-thiPQ; thiamine transporter substrate binding subunit complement(74917..75900) Escherichia coli 55989 7147791 YP_002401206.1 CDS sgrR NC_011748.1 76064 77719 R activates sgrS under glucose-phosphate stress conditions; transcriptional regulator SgrR complement(76064..77719) Escherichia coli 55989 7145304 YP_002401207.1 CDS setA NC_011748.1 78041 79219 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438463, 10209755; Product type t : transporter; broad specificity sugar efflux system 78041..79219 Escherichia coli 55989 7147651 YP_002401208.1 CDS leuD NC_011748.1 79268 79873 R catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D; isopropylmalate isomerase small subunit complement(79268..79873) Escherichia coli 55989 7147636 YP_002401209.1 CDS leuC NC_011748.1 79884 81284 R dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; isopropylmalate isomerase large subunit complement(79884..81284) Escherichia coli 55989 7146692 YP_002401210.1 CDS leuB NC_011748.1 81287 82378 R catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis; 3-isopropylmalate dehydrogenase complement(81287..82378) Escherichia coli 55989 7146691 YP_002401211.1 CDS leuA NC_011748.1 82378 83949 R catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis; 2-isopropylmalate synthase complement(82378..83949) Escherichia coli 55989 7146690 YP_002401212.1 CDS leuL NC_011748.1 84042 84128 R involved in attenuation control of the leuABCD operon in leucine biosynthesis; leu operon leader peptide complement(84042..84128) Escherichia coli 55989 7145306 YP_002401213.1 CDS leuO NC_011748.1 84788 85732 D activator for leuABCD operon; member of LysR family of transcriptional activators; leucine transcriptional activator 84788..85732 Escherichia coli 55989 7146693 YP_002401214.1 CDS ilvI NC_011748.1 86050 87774 D catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive; acetolactate synthase 3 catalytic subunit 86050..87774 Escherichia coli 55989 7146694 YP_002401215.1 CDS ilvH NC_011748.1 87777 88268 D with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit; acetolactate synthase 3 regulatory subunit 87777..88268 Escherichia coli 55989 7146556 YP_002401216.1 CDS fruR NC_011748.1 88448 89452 D binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism; DNA-binding transcriptional regulator FruR 88448..89452 Escherichia coli 55989 7146555 YP_002401217.1 CDS mraZ NC_011748.1 90054 90512 D MraZ; UPF0040; crystal structure shows similarity to AbrB; cell division protein MraZ 90054..90512 Escherichia coli 55989 7146198 YP_002401218.1 CDS mraW NC_011748.1 90514 91455 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042184, 10493123, 2187182, 6350821; Product type e : enzyme; S-adenosyl-methyltransferase MraW 90514..91455 Escherichia coli 55989 7146897 YP_002401219.1 CDS ftsL NC_011748.1 91452 91817 D membrane bound cell division protein at septum containing leucine zipper motif; cell division protein FtsL 91452..91817 Escherichia coli 55989 7146895 YP_002401220.1 CDS ftsI NC_011748.1 91833 93599 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91072213, 92202178, 94095121, 9603865, 9614966, 1332942, 1447153, 2198024, 2677607, 2681146, 3049550, 3911028, 6350821; Product type e : enzyme; transpeptidase involved in septal peptidoglycan synthesis (penicillin-binding protein 3) 91833..93599 Escherichia coli 55989 7146216 YP_002401221.1 CDS murE NC_011748.1 93586 95073 D involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate; UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase 93586..95073 Escherichia coli 55989 7146214 YP_002401222.1 CDS murF NC_011748.1 95070 96428 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88273095, 90248455, 91310568, 97128642, 11090285, 2668880, 9166795; Product type e : enzyme; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase 95070..96428 Escherichia coli 55989 7146925 YP_002401223.1 CDS mraY NC_011748.1 96422 97504 D First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan; phospho-N-acetylmuramoyl-pentapeptide- transferase 96422..97504 Escherichia coli 55989 7146926 YP_002401224.1 CDS murD NC_011748.1 97507 98823 D UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase 97507..98823 Escherichia coli 55989 7146896 YP_002401225.1 CDS ftsW NC_011748.1 98823 100067 D integral membrane protein involved in stabilizing FstZ ring during cell division; cell division protein FtsW 98823..100067 Escherichia coli 55989 7146924 YP_002401226.1 CDS murG NC_011748.1 100064 101131 D UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis; undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase 100064..101131 Escherichia coli 55989 7146219 YP_002401227.1 CDS murC NC_011748.1 101185 102660 D Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis; UDP-N-acetylmuramate--L-alanine ligase 101185..102660 Escherichia coli 55989 7146927 YP_002401228.1 CDS ddl NC_011748.1 102653 103573 D D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanine--D-alanine ligase 102653..103573 Escherichia coli 55989 7146923 YP_002401229.1 CDS ftsQ NC_011748.1 103575 104405 D involved in septum formation; cell division protein FtsQ 103575..104405 Escherichia coli 55989 7145868 YP_002401230.1 CDS ftsA NC_011748.1 104402 105664 D ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane; cell division protein FtsA 104402..105664 Escherichia coli 55989 7146218 YP_002401231.1 CDS ftsZ NC_011748.1 105725 106876 D GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function; cell division protein FtsZ 105725..106876 Escherichia coli 55989 7146210 YP_002401232.1 CDS lpxC NC_011748.1 106977 107894 D zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase 106977..107894 Escherichia coli 55989 7146222 YP_002401233.1 CDS secM NC_011748.1 108125 108637 D secM translational pause allows for the initiation of secA translation; SecA regulator SecM 108125..108637 Escherichia coli 55989 7146737 YP_002401234.1 CDS secA NC_011748.1 108699 111404 D functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins; preprotein translocase subunit SecA 108699..111404 Escherichia coli 55989 7147626 YP_002401235.1 CDS mutT NC_011748.1 111464 111853 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10218109, 89264540, 90136514, 91225007, 97444511, 1309939, 2841285, 3033442, 3288626, 7578113, 9063868; Product type e : enzyme; nucleoside triphosphate pyrophosphohydrolase 111464..111853 Escherichia coli 55989 7147620 YP_002401236.1 CDS yacF NC_011748.1 112160 112903 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(112160..112903) Escherichia coli 55989 7146935 YP_002401237.1 CDS coaE NC_011748.1 112903 113523 R catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis; dephospho-CoA kinase complement(112903..113523) Escherichia coli 55989 7148011 YP_002401238.1 CDS guaC NC_011748.1 113748 114791 D catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate; guanosine 5'-monophosphate oxidoreductase 113748..114791 Escherichia coli 55989 7145734 YP_002401239.1 CDS hofC NC_011748.1 114826 116028 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96099298, 2904262, 7959070; Product type s : structure; type IV pilin biogenesis protein complement(114826..116028) Escherichia coli 55989 7146380 YP_002401240.1 CDS hofB NC_011748.1 116018 117403 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96099298, 7959070; Product type pt : transporter; hypothetical protein complement(116018..117403) Escherichia coli 55989 7146450 YP_002401241.1 CDS ppdD NC_011748.1 117413 117853 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20100782, 20271862, 96099298, 7959070; Product type ps : structure; major pilin subunit complement(117413..117853) Escherichia coli 55989 7146449 YP_002401242.1 CDS nadC NC_011748.1 118056 118949 R catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide; quinolinate phosphoribosyltransferase complement(118056..118949) Escherichia coli 55989 7147225 YP_002401243.1 CDS ampD NC_011748.1 119037 119588 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90113890, 95047240, 2607970, 7959070; Product type e : enzyme; N-acetyl-anhydromuranmyl-L-alanine amidase 119037..119588 Escherichia coli 55989 7146944 YP_002401244.1 CDS ampE NC_011748.1 119585 120439 D involved in regulation of beta-lactamase; signaling protein; regulatory protein AmpE 119585..120439 Escherichia coli 55989 7145495 YP_002401245.1 CDS aroP NC_011748.1 120482 121855 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1104763, 90174991, 9150230; Product type t : transporter; aromatic amino acid transporter complement(120482..121855) Escherichia coli 55989 7145496 YP_002401246.1 CDS pdhR NC_011748.1 122396 123160 D activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex; transcriptional regulator PdhR 122396..123160 Escherichia coli 55989 7145550 YP_002401247.1 CDS aceE NC_011748.1 123321 125984 D E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC; pyruvate dehydrogenase subunit E1 123321..125984 Escherichia coli 55989 7147829 YP_002401248.1 CDS aceF NC_011748.1 125999 127891 D E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains; dihydrolipoamide acetyltransferase 125999..127891 Escherichia coli 55989 7145434 YP_002401249.1 CDS lpd NC_011748.1 128216 129640 D E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide; dihydrolipoamide dehydrogenase 128216..129640 Escherichia coli 55989 7145435 YP_002401250.1 CDS yacH NC_011748.1 129711 131468 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(129711..131468) Escherichia coli 55989 7146722 YP_002401251.1 CDS acnB NC_011748.1 131823 134420 D catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate; bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase 131823..134420 Escherichia coli 55989 7148012 YP_002401252.1 CDS yacL NC_011748.1 134596 134958 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401, 7567469; hypothetical protein 134596..134958 Escherichia coli 55989 7145439 YP_002401253.1 CDS speD NC_011748.1 134996 135790 R S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine; S-adenosylmethionine decarboxylase complement(134996..135790) Escherichia coli 55989 7148013 YP_002401254.1 CDS speE NC_011748.1 135806 136672 R catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine; spermidine synthase complement(135806..136672) Escherichia coli 55989 7147688 YP_002401255.1 CDS yacC NC_011748.1 136778 137296 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2666401; hypothetical protein complement(136778..137296) Escherichia coli 55989 7147689 YP_002401256.1 CDS cueO NC_011748.1 137291 138841 D laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification; multicopper oxidase 137291..138841 Escherichia coli 55989 7148010 YP_002401257.1 CDS gcd NC_011748.1 138888 141278 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10359647, 11604400, 14612441, 91035240, 93123180, 93286127; Product type e : enzyme; glucose dehydrogenase complement(138888..141278) Escherichia coli 55989 7145788 YP_002401258.1 CDS hpt NC_011748.1 141484 142020 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 13808016, 339828, 6787390, 6801015, 12070315; Product type e : enzyme; hypoxanthine phosphoribosyltransferase 141484..142020 Escherichia coli 55989 7146271 YP_002401259.1 CDS can NC_011748.1 142061 142723 R catalyzes the interconversion of bicarbonate and carbon dioxide; carbonic anhydrase complement(142061..142723) Escherichia coli 55989 7146458 YP_002401260.1 CDS yadG NC_011748.1 142832 143758 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: ATP-binding component of ABC superfamily 142832..143758 Escherichia coli 55989 7145663 YP_002401261.1 CDS yadH NC_011748.1 143755 144525 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10474187; Product type pt : transporter; transporter subunit: membrane component of ABC superfamily 143755..144525 Escherichia coli 55989 7148017 YP_002401262.1 CDS yadI NC_011748.1 144630 145070 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; PTS Enzyme IIA 144630..145070 Escherichia coli 55989 7148018 YP_002401263.1 CDS yadE NC_011748.1 145134 146363 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; polysaccharide deacetylase 145134..146363 Escherichia coli 55989 7148019 YP_002401264.1 CDS panD NC_011748.1 146367 146747 R Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5); aspartate alpha-decarboxylase complement(146367..146747) Escherichia coli 55989 7148016 YP_002401265.1 CDS yadD NC_011748.1 147021 147923 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11319082; Product type pe : enzyme; transposase 147021..147923 Escherichia coli 55989 7147112 YP_002401266.1 CDS panC NC_011748.1 147997 148848 R catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine; pantoate--beta-alanine ligase complement(147997..148848) Escherichia coli 55989 7148015 YP_002401267.1 CDS panB NC_011748.1 148860 149654 R catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate; 3-methyl-2-oxobutanoate hydroxymethyltransferase complement(148860..149654) Escherichia coli 55989 7147111 YP_002401268.1 CDS EC55989_0129 NC_011748.1 149767 151041 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8096212; Product type ps : structure; fimbrial-like adhesin protein complement(149767..151041) Escherichia coli 55989 7147110 YP_002401269.1 CDS yadK NC_011748.1 151094 151690 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein complement(151094..151690) Escherichia coli 55989 7144361 YP_002401270.1 CDS yadL NC_011748.1 151717 152319 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein complement(151717..152319) Escherichia coli 55989 7148020 YP_002401271.1 CDS yadM NC_011748.1 152334 152903 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein complement(152334..152903) Escherichia coli 55989 7148021 YP_002401272.1 CDS htrE NC_011748.1 152920 155520 R similar to the fimbrial usher protein PapC; outer membrane usher protein complement(152920..155520) Escherichia coli 55989 7148022 YP_002401273.1 CDS ecpD NC_011748.1 155555 156295 R Evidence 2b : Function of strongly homologous gene; PubMedId : 93352405, 8102362, 15561151; Product type f : factor; chaperone protein EcpD complement(155555..156295) Escherichia coli 55989 7146477 YP_002401274.1 CDS yadN NC_011748.1 156400 156984 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein complement(156400..156984) Escherichia coli 55989 7145975 YP_002401275.1 CDS folK NC_011748.1 157354 157833 R catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP; 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine pyrophosphokinase complement(157354..157833) Escherichia coli 55989 7148023 YP_002401276.1 CDS pcnB NC_011748.1 157830 159248 R Polymerase that creates the 3' poly(A) tail found in some mRNA's; poly(A) polymerase complement(157830..159248) Escherichia coli 55989 7146173 YP_002401277.1 CDS yadB NC_011748.1 159287 160213 R this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu; glutamyl-Q tRNA(Asp) synthetase complement(159287..160213) Escherichia coli 55989 7147122 YP_002401278.1 CDS dksA NC_011748.1 160250 160705 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15294157, 90202727, 2013578, 9298646, 9600841; Product type r : regulator; RNA polymerase-binding transcription factor complement(160250..160705) Escherichia coli 55989 7148014 YP_002401279.1 CDS sfsA NC_011748.1 160883 161587 R Regulatory factor involved in maltose metabolism; sugar fermentation stimulation protein A complement(160883..161587) Escherichia coli 55989 7145926 YP_002401280.1 CDS ligT NC_011748.1 161602 162132 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97094878; Product type e : enzyme; 2'-5' RNA ligase complement(161602..162132) Escherichia coli 55989 7147645 YP_002401281.1 CDS hrpB NC_011748.1 162206 164635 D similar in sequence to the ATP-dependent RNA helicase HrpA; ATP-dependent RNA helicase HrpB 162206..164635 Escherichia coli 55989 7146702 YP_002401282.1 CDS mrcB NC_011748.1 164831 167365 D bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell; penicillin-binding protein 1b 164831..167365 Escherichia coli 55989 7146460 YP_002401283.1 CDS fhuA NC_011748.1 167585 169828 D involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein; ferrichrome outer membrane transporter 167585..169828 Escherichia coli 55989 7146899 YP_002401284.1 CDS fhuC NC_011748.1 169879 170676 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; iron-hydroxamate transporter ATP-binding subunit 169879..170676 Escherichia coli 55989 7146099 YP_002401285.1 CDS fhuD NC_011748.1 170676 171566 D Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores; iron-hydroxamate transporter substrate-binding subunit 170676..171566 Escherichia coli 55989 7146101 YP_002401286.1 CDS fhuB NC_011748.1 171563 173545 D part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome; iron-hydroxamate transporter permease subunit 171563..173545 Escherichia coli 55989 7146102 YP_002401287.1 CDS hemL NC_011748.1 173580 174860 R Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway; glutamate-1-semialdehyde aminotransferase complement(173580..174860) Escherichia coli 55989 7146100 YP_002401288.1 CDS clcA NC_011748.1 175085 176506 D Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation; chloride channel protein 175085..176506 Escherichia coli 55989 7146415 YP_002401289.1 CDS yadR NC_011748.1 176588 176932 D essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors; iron-sulfur cluster insertion protein ErpA 176588..176932 Escherichia coli 55989 7145718 YP_002401290.1 CDS yadS NC_011748.1 176979 177602 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(176979..177602) Escherichia coli 55989 7148024 YP_002401291.1 CDS btuF NC_011748.1 177640 178440 R solute binding component of the vitamin B12 transport system BtuCDF; vitamin B12-transporter protein BtuF complement(177640..178440) Escherichia coli 55989 7148025 YP_002401292.1 CDS pfs NC_011748.1 178433 179131 R enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine; 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase complement(178433..179131) Escherichia coli 55989 7145643 YP_002401293.1 CDS dgt NC_011748.1 179215 180732 D forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate; deoxyguanosinetriphosphate triphosphohydrolase 179215..180732 Escherichia coli 55989 7147145 YP_002401294.1 CDS degP NC_011748.1 180862 182286 D protease Do; required at high temperature; degrades damaged proteins; serine endoprotease 180862..182286 Escherichia coli 55989 7145901 YP_002401295.1 CDS cdaR NC_011748.1 182441 183598 D regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization; carbohydrate diacid transcriptional activator CdaR 182441..183598 Escherichia coli 55989 7145879 YP_002401296.1 CDS yaeH NC_011748.1 183687 184073 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(183687..184073) Escherichia coli 55989 7145682 YP_002401297.1 CDS dapD NC_011748.1 184388 185212 R catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway; 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase complement(184388..185212) Escherichia coli 55989 7148029 YP_002401298.1 CDS glnD NC_011748.1 185243 187915 R catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein; PII uridylyl-transferase complement(185243..187915) Escherichia coli 55989 7145851 YP_002401299.1 CDS map NC_011748.1 187977 188771 R catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn; methionine aminopeptidase complement(187977..188771) Escherichia coli 55989 7146304 YP_002401300.1 CDS EC55989_0162 NC_011748.1 188771 188992 R Evidence 6 : Doubtful CDS; hypothetical protein complement(188771..188992) Escherichia coli 55989 7146786 YP_002401301.1 CDS rpsB NC_011748.1 189139 189864 D one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit; 30S ribosomal protein S2 189139..189864 Escherichia coli 55989 7147744 YP_002401302.1 CDS tsf NC_011748.1 190122 190973 D EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu; elongation factor Ts 190122..190973 Escherichia coli 55989 7147506 YP_002401303.1 CDS pyrH NC_011748.1 191120 191845 D Catalyzes the phosphorylation of UMP to UDP; uridylate kinase 191120..191845 Escherichia coli 55989 7147865 YP_002401304.1 CDS frr NC_011748.1 192137 192694 D Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs; ribosome recycling factor 192137..192694 Escherichia coli 55989 7147323 YP_002401305.1 CDS dxr NC_011748.1 192786 193982 D catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate; 1-deoxy-D-xylulose 5-phosphate reductoisomerase 192786..193982 Escherichia coli 55989 7146193 YP_002401306.1 CDS ispU NC_011748.1 194168 194929 D catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate; undecaprenyl pyrophosphate synthase 194168..194929 Escherichia coli 55989 7145963 YP_002401307.1 CDS cdsA NC_011748.1 194942 195799 D catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate; CDP-diglyceride synthase 194942..195799 Escherichia coli 55989 7146632 YP_002401308.1 CDS yaeL NC_011748.1 195811 197163 D catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response; zinc metallopeptidase RseP 195811..197163 Escherichia coli 55989 7145685 YP_002401309.1 CDS yaeT NC_011748.1 197193 199625 D part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins; outer membrane protein assembly factor YaeT 197193..199625 Escherichia coli 55989 7148031 YP_002401310.1 CDS hlpA NC_011748.1 199747 200232 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15101556, 90201355, 97032152, 99386928, 1987124, 2843433, 9298646, 2167239; Product type f : factor; periplasmic chaperone 199747..200232 Escherichia coli 55989 7148035 YP_002401311.1 CDS lpxD NC_011748.1 200236 201261 D adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase 200236..201261 Escherichia coli 55989 7146444 YP_002401312.1 CDS fabZ NC_011748.1 201366 201821 D in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP; (3R)-hydroxymyristoyl-ACP dehydratase 201366..201821 Escherichia coli 55989 7146738 YP_002401313.1 CDS lpxA NC_011748.1 201825 202613 D catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis; UDP-N-acetylglucosamine acyltransferase 201825..202613 Escherichia coli 55989 7146054 YP_002401314.1 CDS lpxB NC_011748.1 202613 203761 D catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM; lipid-A-disaccharide synthase 202613..203761 Escherichia coli 55989 7146735 YP_002401315.1 CDS rnhB NC_011748.1 203758 204354 D RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids; ribonuclease HII 203758..204354 Escherichia coli 55989 7146736 YP_002401316.1 CDS dnaE NC_011748.1 204391 207873 D catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase; DNA polymerase III subunit alpha 204391..207873 Escherichia coli 55989 7147451 YP_002401317.1 CDS accA NC_011748.1 207886 208845 D catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein; acetyl-CoA carboxylase carboxyltransferase subunit alpha 207886..208845 Escherichia coli 55989 7145935 YP_002401318.1 CDS ldcC NC_011748.1 208944 211085 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97480927, 98195734, 98357244, 9226257, 9723924; Product type e : enzyme; lysine decarboxylase 2, constitutive 208944..211085 Escherichia coli 55989 7145428 YP_002401319.1 CDS yaeR NC_011748.1 211142 211531 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 211142..211531 Escherichia coli 55989 7146681 YP_002401320.1 CDS tilS NC_011748.1 211596 212894 D Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase; tRNA(Ile)-lysidine synthetase 211596..212894 Escherichia coli 55989 7148034 YP_002401321.1 CDS rof NC_011748.1 212943 213197 R Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination; Rho-binding antiterminator complement(212943..213197) Escherichia coli 55989 7147802 YP_002401322.1 CDS yaeP NC_011748.1 213190 213390 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(213190..213390) Escherichia coli 55989 7147458 YP_002401323.1 CDS yaeQ NC_011748.1 213556 214101 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 213556..214101 Escherichia coli 55989 7148032 YP_002401324.1 CDS yaeJ NC_011748.1 214098 214520 D Evidence 4 : Homologs of previously reported genes of unknown function; peptidyl-tRNA hydrolase domain-containing protein 214098..214520 Escherichia coli 55989 7148033 YP_002401325.1 CDS nlpE NC_011748.1 214534 215244 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11830644, 95362641, 95362642; Product type lp : lipoprotein; lipoprotein involved with copper homeostasis and adhesion 214534..215244 Escherichia coli 55989 7148030 YP_002401326.1 CDS EC55989_0189 NC_011748.1 215494 216474 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 215494..216474 Escherichia coli 55989 7147010 YP_002401327.1 CDS proS NC_011748.1 217554 219272 R catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro); prolyl-tRNA synthetase complement(217554..219272) Escherichia coli 55989 7148028 YP_002401328.1 CDS yaeB NC_011748.1 219384 220091 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(219384..220091) Escherichia coli 55989 7147257 YP_002401329.1 CDS rcsF NC_011748.1 220088 220492 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93094132; Product type pr : regulator; outer membrane lipoprotein complement(220088..220492) Escherichia coli 55989 7148026 YP_002401330.1 CDS metQ NC_011748.1 220610 221425 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12169620, 12218041, 12819857, 1459951; Product type t : transporter; DL-methionine transporter substrate-binding subunit complement(220610..221425) Escherichia coli 55989 7147351 YP_002401331.1 CDS metI NC_011748.1 221465 222118 R part of the MetNIQ methionine uptake system; DL-methionine transporter permease complement(221465..222118) Escherichia coli 55989 7146836 YP_002401332.1 CDS metN NC_011748.1 222111 223142 R part of the metNIQ transport system for methionine; DL-methionine transporter ATP-binding subunit complement(222111..223142) Escherichia coli 55989 7146831 YP_002401333.1 CDS gmhB NC_011748.1 223330 223902 D Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate; D,D-heptose 1,7-bisphosphate phosphatase 223330..223902 Escherichia coli 55989 7146835 YP_002401334.1 CDS EC55989_0204 NC_011748.1 229475 229750 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 229475..229750 Escherichia coli 55989 7145290 YP_002401335.1 CDS dkgB NC_011748.1 229800 230603 D catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; 2,5-diketo-D-gluconate reductase B 229800..230603 Escherichia coli 55989 7145339 YP_002401336.1 CDS EC55989_0206 NC_011748.1 230714 231922 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L 230714..231922 Escherichia coli 55989 7147443 YP_002401337.1 CDS yafC NC_011748.1 231938 232852 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(231938..232852) Escherichia coli 55989 7144365 YP_002401338.1 CDS yafD NC_011748.1 233093 233893 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1663890; hypothetical protein 233093..233893 Escherichia coli 55989 7148036 YP_002401339.1 CDS yafE NC_011748.1 233971 234741 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; S-adenosyl-L-methionine-dependent methyltransferase 233971..234741 Escherichia coli 55989 7148037 YP_002401340.1 CDS mltD NC_011748.1 234789 236147 R catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall; membrane-bound lytic murein transglycosylase D complement(234789..236147) Escherichia coli 55989 7148038 YP_002401341.1 CDS gloB NC_011748.1 236219 236974 R catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione; hydroxyacylglutathione hydrolase complement(236219..236974) Escherichia coli 55989 7146866 YP_002401342.1 CDS yafS NC_011748.1 237008 237730 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; S-adenosyl-L-methionine-dependent methyltransferase 237008..237730 Escherichia coli 55989 7146314 YP_002401343.1 CDS rnhA NC_011748.1 237727 238194 R An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids; ribonuclease H complement(237727..238194) Escherichia coli 55989 7148044 YP_002401344.1 CDS dnaQ NC_011748.1 238259 238990 D 3'-5' exonuclease of DNA polymerase III; DNA polymerase III subunit epsilon 238259..238990 Escherichia coli 55989 7147450 YP_002401345.1 CDS yafT NC_011748.1 239526 240311 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; aminopeptidase 239526..240311 Escherichia coli 55989 7145350 YP_002401346.1 CDS yafU NC_011748.1 240937 241866 R Evidence 2b : Function of strongly homologous gene; PubMedId : 15919996; Product type m : membrane component; hypothetical protein complement(240937..241866) Escherichia coli 55989 7145647 YP_002401347.1 CDS EC55989_0218 NC_011748.1 241895 242377 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(241895..242377) Escherichia coli 55989 7148046 YP_002401348.1 CDS EC55989_0219 NC_011748.1 242401 243843 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(242401..243843) Escherichia coli 55989 7144366 YP_002401349.1 CDS EC55989_0220 NC_011748.1 243764 247288 R Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; IcmF-like protein complement(243764..247288) Escherichia coli 55989 7144367 YP_002401350.1 CDS EC55989_0221 NC_011748.1 247307 248788 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(247307..248788) Escherichia coli 55989 7144368 YP_002401351.1 CDS EC55989_0222 NC_011748.1 248727 249470 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(248727..249470) Escherichia coli 55989 7144369 YP_002401352.1 CDS EC55989_0223 NC_011748.1 249467 252340 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; ATP-dependent Clp proteinase Aec27 ATP-binding chain, with chaperone activity complement(249467..252340) Escherichia coli 55989 7144370 YP_002401353.1 CDS EC55989_0224 NC_011748.1 252235 252996 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; membrane protein Aec26 complement(252235..252996) Escherichia coli 55989 7144371 YP_002401354.1 CDS EC55989_0225 NC_011748.1 253001 254332 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(253001..254332) Escherichia coli 55989 7144372 YP_002401355.1 CDS EC55989_0226 NC_011748.1 254335 254859 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(254335..254859) Escherichia coli 55989 7144373 YP_002401356.1 CDS EC55989_0227 NC_011748.1 254856 256157 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(254856..256157) Escherichia coli 55989 7144374 YP_002401357.1 CDS EC55989_0228 NC_011748.1 256161 257249 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(256161..257249) Escherichia coli 55989 7144375 YP_002401358.1 CDS EC55989_0229 NC_011748.1 257207 259057 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(257207..259057) Escherichia coli 55989 7144376 YP_002401359.1 CDS EC55989_0230 NC_011748.1 259061 259474 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(259061..259474) Escherichia coli 55989 7144377 YP_002401360.1 CDS EC55989_0231 NC_011748.1 259481 260956 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(259481..260956) Escherichia coli 55989 7144378 YP_002401361.1 CDS EC55989_0232 NC_011748.1 261007 261231 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(261007..261231) Escherichia coli 55989 7144379 YP_002401362.1 CDS EC55989_0233 NC_011748.1 261266 261766 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(261266..261766) Escherichia coli 55989 7144380 YP_002401363.1 CDS EC55989_0234 NC_011748.1 262193 262336 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 262193..262336 Escherichia coli 55989 7144381 YP_002401364.1 CDS EC55989_0235 NC_011748.1 262463 262981 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 262463..262981 Escherichia coli 55989 7144382 YP_002401365.1 CDS EC55989_0236 NC_011748.1 263191 265332 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 263191..265332 Escherichia coli 55989 7144383 YP_002401366.1 CDS ydcD NC_011748.1 269055 269537 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 269055..269537 Escherichia coli 55989 7147405 YP_002401367.1 CDS yncI NC_011748.1 269718 270464 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7868617, 8387990; hypothetical protein 269718..270464 Escherichia coli 55989 7148384 YP_002401368.1 CDS yncM NC_011748.1 270508 270708 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7868617, 8387990; hypothetical protein 270508..270708 Escherichia coli 55989 7149297 YP_002401369.1 CDS yhhI NC_011748.1 271022 272083 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype; transposase 271022..272083 Escherichia coli 55989 7149299 YP_002401370.1 CDS yafV NC_011748.1 272125 272895 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8526497; Product type pe : enzyme; hypothetical protein complement(272125..272895) Escherichia coli 55989 7148979 YP_002401371.1 CDS ivy NC_011748.1 273049 273522 D inactivates vertebrate C-type lysozyme; C-lysozyme inhibitor 273049..273522 Escherichia coli 55989 7148047 YP_002401372.1 CDS fadE NC_011748.1 273565 276009 R functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA; acyl-CoA dehydrogenase complement(273565..276009) Escherichia coli 55989 7146643 YP_002401373.1 CDS gmhA NC_011748.1 276249 276827 D catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate; phosphoheptose isomerase 276249..276827 Escherichia coli 55989 7146058 YP_002401374.1 CDS yafJ NC_011748.1 277033 277800 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; class-II glutamine amidotransferase 277033..277800 Escherichia coli 55989 7146721 YP_002401375.1 CDS yafK NC_011748.1 277771 278511 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(277771..278511) Escherichia coli 55989 7148039 YP_002401376.1 CDS yafQ NC_011748.1 278667 278945 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15009896; Product type f : factor; toxin of the YafQ-DinJ toxin-antitoxin system complement(278667..278945) Escherichia coli 55989 7148040 YP_002401377.1 CDS dinJ NC_011748.1 278948 279208 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99451883; Product type pf : factor; antitoxin of YafQ-DinJ toxin-antitoxin system complement(278948..279208) Escherichia coli 55989 7148043 YP_002401378.1 CDS yafL NC_011748.1 279418 280167 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase 279418..280167 Escherichia coli 55989 7145919 YP_002401379.1 CDS EC55989_0252 NC_011748.1 280224 280580 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(280224..280580) Escherichia coli 55989 7148041 YP_002401380.1 CDS EC55989_0253 NC_011748.1 280573 280872 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(280573..280872) Escherichia coli 55989 7144386 YP_002401381.1 CDS fhiA NC_011748.1 280956 282695 R Evidence 7 : Gene remnant; Product type s : structure; flagellar system protein complement(280956..282695) Escherichia coli 55989 7144387 YP_002401382.1 CDS mbhA NC_011748.1 282535 283425 D Evidence 2b : Function of strongly homologous gene; PubMedId : 15687208; Product type s : structure; hypothetical protein 282535..283425 Escherichia coli 55989 7146097 YP_002401383.1 CDS dinB NC_011748.1 283496 284551 D involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function; DNA polymerase IV 283496..284551 Escherichia coli 55989 7146792 YP_002401384.1 CDS EC55989_0258 NC_011748.1 284903 286111 R Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L complement(284903..286111) Escherichia coli 55989 7148042 YP_002401385.1 CDS EC55989_0259 NC_011748.1 286557 287723 D mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY; hypothetical protein 286557..287723 Escherichia coli 55989 7147437 YP_002401386.1 CDS prfH NC_011748.1 287834 288334 D similar to release factor 1 and 2; peptide chain release factor-like protein 287834..288334 Escherichia coli 55989 7144389 YP_002401387.1 CDS pepD NC_011748.1 288391 289848 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1695895, 21101837, 88121730, 92204123, 2651887; Product type e : enzyme; aminoacyl-histidine dipeptidase complement(288391..289848) Escherichia coli 55989 7147243 YP_002401388.1 CDS gpt NC_011748.1 290109 290567 D catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively; xanthine-guanine phosphoribosyltransferase 290109..290567 Escherichia coli 55989 7147132 YP_002401389.1 CDS frsA NC_011748.1 290659 291903 D forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation; fermentation/respiration switch protein 290659..291903 Escherichia coli 55989 7146364 YP_002401390.1 CDS crl NC_011748.1 291961 292362 D involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS; DNA-binding transcriptional regulator Crl 291961..292362 Escherichia coli 55989 7146194 YP_002401391.1 CDS phoE NC_011748.1 292401 293456 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89178658, 89380253, 92219258, 98090453, 1380671, 1848301, 1848682, 6089111, 6341601, 7679770; Product type t : transporter; outer membrane phosphoporin protein E complement(292401..293456) Escherichia coli 55989 7145757 YP_002401392.1 CDS proB NC_011748.1 293744 294847 D catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis; gamma-glutamyl kinase 293744..294847 Escherichia coli 55989 7147181 YP_002401393.1 CDS proA NC_011748.1 294859 296112 D Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway; gamma-glutamyl phosphate reductase 294859..296112 Escherichia coli 55989 7147253 YP_002401394.1 CDS EC55989_0268 NC_011748.1 296469 297683 D prophage CPS-53 integrase 296469..297683 Escherichia coli 55989 7145361 YP_002401395.1 CDS EC55989_0269 NC_011748.1 297806 298609 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 297806..298609 Escherichia coli 55989 7144390 YP_002401396.1 CDS EC55989_0270 NC_011748.1 298804 299001 D Phage transcriptional regulator, AlpA 298804..299001 Escherichia coli 55989 7144391 YP_002401397.1 CDS EC55989_0271 NC_011748.1 299080 299880 D Evidence 2b : Function of strongly homologous gene; Product type pr : regulator; AntA/AntB antirepressor 299080..299880 Escherichia coli 55989 7144392 YP_002401398.1 CDS EC55989_0272 NC_011748.1 299873 301459 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 299873..301459 Escherichia coli 55989 7144393 YP_002401399.1 CDS EC55989_0273 NC_011748.1 300598 300903 R hypothetical protein complement(300598..300903) Escherichia coli 55989 7144394 YP_002401400.1 CDS EC55989_0274 NC_011748.1 301452 301817 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 301452..301817 Escherichia coli 55989 7144395 YP_002401401.1 CDS EC55989_0275 NC_011748.1 301810 302010 D hypothetical protein 301810..302010 Escherichia coli 55989 7144396 YP_002401402.1 CDS EC55989_0276 NC_011748.1 302015 302305 D hypothetical protein 302015..302305 Escherichia coli 55989 7144397 YP_002401403.1 CDS EC55989_0277 NC_011748.1 302302 304434 D hypothetical protein 302302..304434 Escherichia coli 55989 7144398 YP_002401404.1 CDS EC55989_0278 NC_011748.1 304893 305450 D Activator of ProP osmoprotectant transporter 304893..305450 Escherichia coli 55989 7144399 YP_002401405.1 CDS EC55989_0279 NC_011748.1 305447 305734 D Protein perC (Protein bfpW) 305447..305734 Escherichia coli 55989 7144400 YP_002401406.1 CDS EC55989_0280 NC_011748.1 305869 307011 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 305869..307011 Escherichia coli 55989 7144401 YP_002401407.1 CDS EC55989_0281 NC_011748.1 307076 307399 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 307076..307399 Escherichia coli 55989 7144402 YP_002401408.1 CDS EC55989_0283 NC_011748.1 307842 308114 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 307842..308114 Escherichia coli 55989 7144403 YP_002401409.1 CDS EC55989_0284 NC_011748.1 308196 308741 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 308196..308741 Escherichia coli 55989 7144404 YP_002401410.1 CDS EC55989_0285 NC_011748.1 309345 310340 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 309345..310340 Escherichia coli 55989 7144405 YP_002401411.1 CDS EC55989_0286 NC_011748.1 310333 311313 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 310333..311313 Escherichia coli 55989 7144406 YP_002401412.1 CDS yagP NC_011748.1 311773 312183 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator complement(311773..312183) Escherichia coli 55989 7144407 YP_002401413.1 CDS yagQ NC_011748.1 312162 313118 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(312162..313118) Escherichia coli 55989 7148048 YP_002401414.1 CDS yagR NC_011748.1 313128 315326 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase with molybdenum-binding domain complement(313128..315326) Escherichia coli 55989 7148049 YP_002401415.1 CDS yagS NC_011748.1 315323 316279 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase with FAD-binding domain complement(315323..316279) Escherichia coli 55989 7148050 YP_002401416.1 CDS yagT NC_011748.1 316276 316965 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; xanthine dehydrogenase iron-sulfur-binding subunit complement(316276..316965) Escherichia coli 55989 7148051 YP_002401417.1 CDS yagU NC_011748.1 317383 317997 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 317383..317997 Escherichia coli 55989 7148052 YP_002401418.1 CDS yagV NC_011748.1 318887 319597 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(318887..319597) Escherichia coli 55989 7148053 YP_002401419.1 CDS yagW NC_011748.1 319566 321209 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; surface or protein complement(319566..321209) Escherichia coli 55989 7148055 YP_002401420.1 CDS yagX NC_011748.1 321199 323724 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(321199..323724) Escherichia coli 55989 7148056 YP_002401421.1 CDS yagY NC_011748.1 323750 324418 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(323750..324418) Escherichia coli 55989 7148057 YP_002401422.1 CDS ecpA NC_011748.1 324476 325063 R Evidence 2b : Function of strongly homologous gene; PubMedId : 17563352, 11466275; Product type s : structure; common pilus ECP complement(324476..325063) Escherichia coli 55989 7148058 YP_002401423.1 CDS ykgK NC_011748.1 325138 325728 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator complement(325138..325728) Escherichia coli 55989 7145974 YP_002401424.1 CDS ykgL NC_011748.1 326503 326730 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 326503..326730 Escherichia coli 55989 7149243 YP_002401425.1 CDS rpmE2 NC_011748.1 326905 327168 R RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 complement(326905..327168) Escherichia coli 55989 7149244 YP_002401426.1 CDS EC55989_0302 NC_011748.1 328749 333002 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; adhesin 328749..333002 Escherichia coli 55989 7149245 YP_002401427.1 CDS ykgA NC_011748.1 333123 334013 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; Putatve transcriptional regulator ykgA complement(333123..334013) Escherichia coli 55989 7144408 YP_002401428.1 CDS ykgB NC_011748.1 334570 335163 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(334570..335163) Escherichia coli 55989 7149234 YP_002401429.1 CDS ykgI NC_011748.1 335175 335411 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(335175..335411) Escherichia coli 55989 7149235 YP_002401430.1 CDS ykgC NC_011748.1 335520 336845 R Involved in disulfide oxidoreductase activity and electron transport; pyridine nucleotide-disulfide oxidoreductase complement(335520..336845) Escherichia coli 55989 7149242 YP_002401431.1 CDS ykgD NC_011748.1 337071 337925 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; AraC-type DNA-binding transcriptional regulator 337071..337925 Escherichia coli 55989 7149236 YP_002401432.1 CDS ykgE NC_011748.1 338452 339171 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydroxyacid oxidoreductase (Fe-S centre) 338452..339171 Escherichia coli 55989 7149237 YP_002401433.1 CDS ykgF NC_011748.1 339182 340609 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase subunit with NAD(P)-binding domain and ferridoxin-like domain 339182..340609 Escherichia coli 55989 7149238 YP_002401434.1 CDS ykgG NC_011748.1 340602 341297 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 340602..341297 Escherichia coli 55989 7149239 YP_002401435.1 CDS EC55989_0311 NC_011748.1 341371 341568 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(341371..341568) Escherichia coli 55989 7149240 YP_002401436.1 CDS ykgH NC_011748.1 341543 342208 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(341543..342208) Escherichia coli 55989 7144409 YP_002401437.1 CDS betA NC_011748.1 342421 344091 R catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine; choline dehydrogenase complement(342421..344091) Escherichia coli 55989 7149241 YP_002401438.1 CDS betB NC_011748.1 344105 345577 R catalyzes the formation of betaine from betaine aldehyde; betaine aldehyde dehydrogenase complement(344105..345577) Escherichia coli 55989 7145610 YP_002401439.1 CDS betI NC_011748.1 345591 346178 R HTH-type; bet1; Repressor involved in choline regulation of the bet genes; transcriptional regulator BetI complement(345591..346178) Escherichia coli 55989 7145611 YP_002401440.1 CDS betT NC_011748.1 346307 348340 D proton-motive-force-driven choline transporter; choline transport protein BetT 346307..348340 Escherichia coli 55989 7145612 YP_002401441.1 CDS EC55989_0317 NC_011748.1 348847 352896 D Evidence 2b : Function of strongly homologous gene; Product type pm : membrane component; AidA-I adhesin-like protein 348847..352896 Escherichia coli 55989 7145613 YP_002401442.1 CDS yahA NC_011748.1 353038 354126 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15995192; Product type e : enzyme; cyclic di-GMP phosphodiesterase 353038..354126 Escherichia coli 55989 7144410 YP_002401443.1 CDS yahB NC_011748.1 354168 355100 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(354168..355100) Escherichia coli 55989 7148059 YP_002401444.1 CDS yahC NC_011748.1 355192 355689 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(355192..355689) Escherichia coli 55989 7148060 YP_002401445.1 CDS yahD NC_011748.1 355947 356552 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; protein with ankyrin domain 355947..356552 Escherichia coli 55989 7148061 YP_002401446.1 CDS yahE NC_011748.1 356592 357455 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 356592..357455 Escherichia coli 55989 7148062 YP_002401447.1 CDS yahF NC_011748.1 357445 358992 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; enzyme with acyl-CoA domain 357445..358992 Escherichia coli 55989 7148063 YP_002401448.1 CDS yahG NC_011748.1 358992 360410 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 358992..360410 Escherichia coli 55989 7148064 YP_002401449.1 CDS yahI NC_011748.1 360553 361503 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7711027, 11523892; Product type pe : enzyme; carbamate kinase 360553..361503 Escherichia coli 55989 7148065 YP_002401450.1 CDS yahJ NC_011748.1 361513 362895 D metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain; deaminase 361513..362895 Escherichia coli 55989 7148066 YP_002401451.1 CDS EC55989_0327 NC_011748.1 363164 363604 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 363164..363604 Escherichia coli 55989 7148067 YP_002401452.1 CDS EC55989_0328 NC_011748.1 363855 364841 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; periplasmic binding protein, substrate ribose (sugar-binding protein), ABC-type transport system 363855..364841 Escherichia coli 55989 7144411 YP_002401453.1 CDS EC55989_0329 NC_011748.1 364875 366374 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; ATP-binding component of ABC sugar transport system 364875..366374 Escherichia coli 55989 7144412 YP_002401454.1 CDS EC55989_0330 NC_011748.1 366367 367338 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; permease component of sugar ABC transport system 366367..367338 Escherichia coli 55989 7144413 YP_002401455.1 CDS EC55989_0331 NC_011748.1 367305 368291 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; permease component of sugar ABC transport system 367305..368291 Escherichia coli 55989 7144414 YP_002401456.1 CDS yahK NC_011748.1 368378 369427 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase, Zn-dependent and NAD(P)-binding 368378..369427 Escherichia coli 55989 7144415 YP_002401457.1 CDS yahL NC_011748.1 369670 370485 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 369670..370485 Escherichia coli 55989 7148068 YP_002401458.1 CDS yahM NC_011748.1 370897 371142 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 370897..371142 Escherichia coli 55989 7145372 YP_002401459.1 CDS yahN NC_011748.1 371159 371830 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12879215; Product type t : transporter; neutral amino-acid efflux system complement(371159..371830) Escherichia coli 55989 7148070 YP_002401460.1 CDS yahO NC_011748.1 371977 372252 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 371977..372252 Escherichia coli 55989 7148071 YP_002401461.1 CDS prpR NC_011748.1 372353 373939 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9325432, 15805526; Product type r : regulator; DNA-binding transcriptional activator complement(372353..373939) Escherichia coli 55989 7148072 YP_002401462.1 CDS prpB NC_011748.1 374177 375067 D catalyzes the formation of pyruvate and succinate from 2-methylisocitrate; 2-methylisocitrate lyase 374177..375067 Escherichia coli 55989 7147266 YP_002401463.1 CDS prpC NC_011748.1 375112 376281 D catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity; methylcitrate synthase 375112..376281 Escherichia coli 55989 7147262 YP_002401464.1 CDS prpD NC_011748.1 376315 377766 D functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C; 2-methylcitrate dehydratase 376315..377766 Escherichia coli 55989 7147263 YP_002401465.1 CDS prpE NC_011748.1 377806 379692 D catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent; propionyl-CoA synthetase 377806..379692 Escherichia coli 55989 7147264 YP_002401466.1 CDS EC55989_0342 NC_011748.1 380155 381135 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 380155..381135 Escherichia coli 55989 7147265 YP_002401467.1 CDS codB NC_011748.1 381397 382656 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92349961; Product type t : transporter; cytosine permease 381397..382656 Escherichia coli 55989 7144416 YP_002401468.1 CDS codA NC_011748.1 382646 383929 D Catalyzes the deamination of cytosine to uracil and ammonia; cytosine deaminase 382646..383929 Escherichia coli 55989 7145740 YP_002401469.1 CDS cynR NC_011748.1 383969 384868 R controls the expression of the cynTSX operon involved in degrading and using cyanate as a sole nitrogen source; DNA-binding transcriptional regulator CynR complement(383969..384868) Escherichia coli 55989 7145739 YP_002401470.1 CDS cynT NC_011748.1 384978 385637 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91242169, 92156106, 94075239, 3049588; Product type e : enzyme; carbonic anhydrase 384978..385637 Escherichia coli 55989 7145811 YP_002401471.1 CDS cynS NC_011748.1 385668 386138 D catalyzes the reaction of cyanate and bicarbonate to produce ammonia and carbon dioxide; cyanate hydratase 385668..386138 Escherichia coli 55989 7145813 YP_002401472.1 CDS cynX NC_011748.1 386171 387325 D MFS transporter family member induced in the presence of cyanate as part of a 3 gene operon; not essential; cyanate transporter 386171..387325 Escherichia coli 55989 7145812 YP_002401473.1 CDS lacA NC_011748.1 387428 388039 R transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown; galactoside O-acetyltransferase complement(387428..388039) Escherichia coli 55989 7145814 YP_002401474.1 CDS lacY NC_011748.1 388105 389358 R lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease complement(388105..389358) Escherichia coli 55989 7146675 YP_002401475.1 CDS lacZ NC_011748.1 389410 392484 R forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon; beta-D-galactosidase complement(389410..392484) Escherichia coli 55989 7146677 YP_002401476.1 CDS lacI NC_011748.1 392607 393689 R transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer; lac repressor complement(392607..393689) Escherichia coli 55989 7146678 YP_002401477.1 CDS mhpR NC_011748.1 393766 394713 R activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional activator MhpR complement(393766..394713) Escherichia coli 55989 7146676 YP_002401478.1 CDS mhpA NC_011748.1 394790 396454 D catalyzes the formation of 3-(2,3-dihydroxyphenyl)propionate from 3-(3-hydroxyphenyl)propionate; 3-(3-hydroxyphenyl)propionate hydroxylase 394790..396454 Escherichia coli 55989 7146850 YP_002401479.1 CDS mhpB NC_011748.1 396456 397400 D catalyzes the cleavage of 3-(2,3-dihydroxyphenyl) propionate into 2-hydroxy-6-oxonona-2,4-diene-1,9-dioate; part of the 3-phenylpropionic acid degradation pathway; member of the protocatechuate 4,5-dioxygenase family; 3-(2,3-dihydroxyphenyl)propionate dioxygenase 396456..397400 Escherichia coli 55989 7146844 YP_002401480.1 CDS mhpC NC_011748.1 397403 398284 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87008429, 94002258, 15663942; Product type e : enzyme; 2-hydroxy-6-ketonona-2,4-dienedioic acid hydrolase 397403..398284 Escherichia coli 55989 7146845 YP_002401481.1 CDS mhpD NC_011748.1 398294 399103 D catalyzes the formation of 2-keto-4-hydroxypentanoic acid from 2-hydroxypentadienoic acid; 2-keto-4-pentenoate hydratase 398294..399103 Escherichia coli 55989 7146846 YP_002401482.1 CDS mhpF NC_011748.1 399100 400050 D catalyzes the formation of acetyl-CoA from acetalaldehyde; acetaldehyde dehydrogenase 399100..400050 Escherichia coli 55989 7146847 YP_002401483.1 CDS mhpE NC_011748.1 400047 401060 D catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate; 4-hydroxy-2-ketovalerate aldolase 400047..401060 Escherichia coli 55989 7146849 YP_002401484.1 CDS mhpT NC_011748.1 401236 402447 D Evidence 2b : Function of strongly homologous gene; PubMedId : 7961399; Product type t : transporter; 3-hydroxyphenylpropionic transporter MhpT 401236..402447 Escherichia coli 55989 7146848 YP_002401485.1 CDS yaiL NC_011748.1 402549 403088 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15115803, 12878731, 13129938; Product type e : enzyme; nucleoprotein/polynucleotide-associated enzyme 402549..403088 Escherichia coli 55989 7146851 YP_002401486.1 CDS EC55989_0363 NC_011748.1 403338 404318 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 403338..404318 Escherichia coli 55989 7148078 YP_002401487.1 CDS frmB NC_011748.1 404593 405426 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800, 15466022; Product type e : enzyme; S-formylglutathione hydrolase complement(404593..405426) Escherichia coli 55989 7144417 YP_002401488.1 CDS frmA NC_011748.1 405519 406628 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15466022, 87172301, 1731906; Product type e : enzyme; alcohol dehydrogenase complement(405519..406628) Escherichia coli 55989 7146190 YP_002401489.1 CDS frmR NC_011748.1 406663 406938 R formaldehyde-induced negative regulator of the frmRAB operon; regulator protein FrmR complement(406663..406938) Escherichia coli 55989 7146189 YP_002401490.1 CDS yaiO NC_011748.1 407124 407897 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(407124..407897) Escherichia coli 55989 7146192 YP_002401491.1 CDS yaiX NC_011748.1 407899 408609 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transferase complement(407899..408609) Escherichia coli 55989 7148079 YP_002401492.1 CDS yaiP NC_011748.1 408458 409654 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane-associated glycosyltransferase complement(408458..409654) Escherichia coli 55989 7148084 YP_002401493.1 CDS yaiS NC_011748.1 409664 410335 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(409664..410335) Escherichia coli 55989 7148080 YP_002401494.1 CDS tauA NC_011748.1 410951 411913 D with TauB and TauC is responsible for taurine uptake.; taurine transporter substrate binding subunit 410951..411913 Escherichia coli 55989 7148081 YP_002401495.1 CDS tauB NC_011748.1 411926 412693 D Part of the ABC transporter complex tauABC involved in taurine import; taurine transporter ATP-binding subunit 411926..412693 Escherichia coli 55989 7147758 YP_002401496.1 CDS tauC NC_011748.1 412690 413517 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401024, 96404792; Product type t : transporter; taurine transporter subunit 412690..413517 Escherichia coli 55989 7147759 YP_002401497.1 CDS tauD NC_011748.1 413514 414365 D catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers; taurine dioxygenase 413514..414365 Escherichia coli 55989 7147760 YP_002401498.1 CDS hemB NC_011748.1 414471 415445 R catalyzes the formation of porphobilinogen from 5-aminolevulinate; delta-aminolevulinic acid dehydratase complement(414471..415445) Escherichia coli 55989 7147761 YP_002401499.1 CDS EC55989_0378 NC_011748.1 415969 418857 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; flagellin structural protein; protein 415969..418857 Escherichia coli 55989 7146408 YP_002401500.1 CDS yaiV NC_011748.1 418900 419568 D Evidence 4 : Homologs of previously reported genes of unknown function; DNA-binding transcriptional regulator 418900..419568 Escherichia coli 55989 7144418 YP_002401501.1 CDS ampH NC_011748.1 419569 420726 R this protein has no known enzymatic function; beta-lactam binding protein AmpH complement(419569..420726) Escherichia coli 55989 7148082 YP_002401502.1 CDS EC55989_0381 NC_011748.1 420864 421058 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 420864..421058 Escherichia coli 55989 7145498 YP_002401503.1 CDS sbmA NC_011748.1 421078 422298 D in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope; transporter 421078..422298 Escherichia coli 55989 7144419 YP_002401504.1 CDS yaiW NC_011748.1 422311 423405 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; lipoprotein 422311..423405 Escherichia coli 55989 7147609 YP_002401505.1 CDS yaiY NC_011748.1 423464 423772 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(423464..423772) Escherichia coli 55989 7148083 YP_002401506.1 CDS yaiZ NC_011748.1 423900 424244 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 423900..424244 Escherichia coli 55989 7148085 YP_002401507.1 CDS ddl NC_011748.1 424268 425362 R D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli; D-alanyl-alanine synthetase A complement(424268..425362) Escherichia coli 55989 7148086 YP_002401508.1 CDS EC55989_0387 NC_011748.1 425440 425643 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 425440..425643 Escherichia coli 55989 7145867 YP_002401509.1 CDS yaiB NC_011748.1 425825 426085 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 425825..426085 Escherichia coli 55989 7144420 YP_002401510.1 CDS insB NC_011748.1 426499 427002 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(426499..427002) Escherichia coli 55989 7147178 YP_002401511.1 CDS insA NC_011748.1 426921 427196 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(426921..427196) Escherichia coli 55989 7146580 YP_002401512.1 CDS psiF NC_011748.1 428497 428817 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3533724, 2160940; Product type f : factor; hypothetical protein 428497..428817 Escherichia coli 55989 7147179 YP_002401513.1 CDS adrA NC_011748.1 428919 430034 D catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis; diguanylate cyclase AdrA 428919..430034 Escherichia coli 55989 7147269 YP_002401514.1 CDS proC NC_011748.1 430051 430860 R catalyzes the formation of L-proline from pyrroline-5-carboxylate; pyrroline-5-carboxylate reductase complement(430051..430860) Escherichia coli 55989 7148075 YP_002401515.1 CDS yaiI NC_011748.1 430980 431438 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 430980..431438 Escherichia coli 55989 7147254 YP_002401516.1 CDS aroL NC_011748.1 431621 432145 D type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase 431621..432145 Escherichia coli 55989 7148077 YP_002401517.1 CDS yaiA NC_011748.1 432195 432386 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 432195..432386 Escherichia coli 55989 7145548 YP_002401518.1 CDS aroM NC_011748.1 432644 433321 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 86085675, 3001025; hypothetical protein 432644..433321 Escherichia coli 55989 7148073 YP_002401519.1 CDS yaiE NC_011748.1 433393 433677 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 433393..433677 Escherichia coli 55989 7145549 YP_002401520.1 CDS EC55989_0401 NC_011748.1 433938 434300 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 433938..434300 Escherichia coli 55989 7148076 YP_002401521.1 CDS rdgC NC_011748.1 434378 435289 R Required for efficient pilin antigenic variation; recombination associated protein complement(434378..435289) Escherichia coli 55989 7144421 YP_002401522.1 CDS mak NC_011748.1 435414 436322 D catalyzes phosphorylation of fructose; cytosolic enzyme; fructokinase 435414..436322 Escherichia coli 55989 7147352 YP_002401523.1 CDS araJ NC_011748.1 436465 437649 R member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers; MFS transport protein AraJ complement(436465..437649) Escherichia coli 55989 7146767 YP_002401524.1 CDS sbcC NC_011748.1 437775 440918 R with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity; exonuclease SbcC complement(437775..440918) Escherichia coli 55989 7145521 YP_002401525.1 CDS sbcD NC_011748.1 440915 442117 R with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity; exonuclease SbcD complement(440915..442117) Escherichia coli 55989 7147607 YP_002401526.1 CDS phoB NC_011748.1 442307 442996 D two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB; transcriptional regulator PhoB 442307..442996 Escherichia coli 55989 7147608 YP_002401527.1 CDS phoR NC_011748.1 443054 444349 D membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB; phosphate regulon sensor protein 443054..444349 Escherichia coli 55989 7147180 YP_002401528.1 CDS EC55989_0409 NC_011748.1 444360 444470 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(444360..444470) Escherichia coli 55989 7147185 YP_002401529.1 CDS brnQ NC_011748.1 444756 446075 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 3078876, 6998958, 3550103, 7984428; Product type t : transporter; branched chain amino acid transporter (LIV-II) 444756..446075 Escherichia coli 55989 7144422 YP_002401530.1 CDS proY NC_011748.1 446151 447524 D cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation; proline-specific permease 446151..447524 Escherichia coli 55989 7145636 YP_002401531.1 CDS malZ NC_011748.1 447680 449497 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92184757, 1706703, 1918057; Product type e : enzyme; maltodextrin glucosidase 447680..449497 Escherichia coli 55989 7147261 YP_002401532.1 CDS acpH NC_011748.1 449502 450083 R Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP; ACP phosphodieterase complement(449502..450083) Escherichia coli 55989 7146780 YP_002401533.1 CDS queA NC_011748.1 450176 451246 D Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step; S-adenosylmethionine--tRNA ribosyltransferase-isomerase 450176..451246 Escherichia coli 55989 7145440 YP_002401534.1 CDS tgt NC_011748.1 451302 452429 D Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr); queuine tRNA-ribosyltransferase 451302..452429 Escherichia coli 55989 7147331 YP_002401535.1 CDS yajC NC_011748.1 452452 452784 D member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex; preprotein translocase subunit YajC 452452..452784 Escherichia coli 55989 7147781 YP_002401536.1 CDS secD NC_011748.1 452812 454659 D part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; preprotein translocase subunit SecD 452812..454659 Escherichia coli 55989 7148087 YP_002401537.1 CDS secF NC_011748.1 454670 455641 D forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF; preprotein translocase subunit SecF 454670..455641 Escherichia coli 55989 7147622 YP_002401538.1 CDS yajD NC_011748.1 455770 456117 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 455770..456117 Escherichia coli 55989 7147624 YP_002401539.1 CDS tsx NC_011748.1 456294 457178 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91092502, 91358319, 93352541; Product type m : membrane component; nucleoside channel phage T6/colicin K receptor complement(456294..457178) Escherichia coli 55989 7148088 YP_002401540.1 CDS nrdR NC_011748.1 458167 458616 D Evidence 2b : Function of strongly homologous gene; Product type r : regulator; transcriptional regulator NrdR 458167..458616 Escherichia coli 55989 7144423 YP_002401541.1 CDS ribD NC_011748.1 458620 459723 D riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil; bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase 458620..459723 Escherichia coli 55989 7147026 YP_002401542.1 CDS ribH NC_011748.1 459812 460282 D RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not; 6,7-dimethyl-8-ribityllumazine synthase 459812..460282 Escherichia coli 55989 7147412 YP_002401543.1 CDS nusB NC_011748.1 460302 460721 D Regulates rRNA biosynthesis by transcriptional antitermination; transcription antitermination protein NusB 460302..460721 Escherichia coli 55989 7147413 YP_002401544.1 CDS thiL NC_011748.1 460799 461776 D catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP; thiamine monophosphate kinase 460799..461776 Escherichia coli 55989 7147059 YP_002401545.1 CDS pgpA NC_011748.1 461754 462272 D hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate; phosphatidylglycerophosphatase A 461754..462272 Escherichia coli 55989 7147789 YP_002401546.1 CDS yajO NC_011748.1 462326 463300 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217, 16077126; Product type e : enzyme; aldoketo-oxidoreductase complement(462326..463300) Escherichia coli 55989 7147154 YP_002401547.1 CDS dxs NC_011748.1 463355 465217 R catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate; 1-deoxy-D-xylulose-5-phosphate synthase complement(463355..465217) Escherichia coli 55989 7148092 YP_002401548.1 CDS ispA NC_011748.1 465242 466141 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89291702, 91210228; Product type e : enzyme; geranyltranstransferase complement(465242..466141) Escherichia coli 55989 7145964 YP_002401549.1 CDS xseB NC_011748.1 466141 466383 R catalyzes the bidirectional exonucleolytic cleavage of DNA; exodeoxyribonuclease VII small subunit complement(466141..466383) Escherichia coli 55989 7146625 YP_002401550.1 CDS thiI NC_011748.1 466589 468037 D Required for the synthesis of the thiazole moiety; thiamine biosynthesis protein ThiI 466589..468037 Escherichia coli 55989 7147993 YP_002401551.1 CDS yajL NC_011748.1 468091 468681 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 97039868, 99173753, 99311269; DJ-1 family protein complement(468091..468681) Escherichia coli 55989 7147788 YP_002401552.1 CDS panE NC_011748.1 468644 469555 R ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis; 2-dehydropantoate 2-reductase complement(468644..469555) Escherichia coli 55989 7148091 YP_002401553.1 CDS yajQ NC_011748.1 469723 470214 D nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription; nucleotide-binding protein 469723..470214 Escherichia coli 55989 7147113 YP_002401554.1 CDS yajR NC_011748.1 470342 471706 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; major facilitator family transporter complement(470342..471706) Escherichia coli 55989 7148093 YP_002401555.1 CDS EC55989_0439 NC_011748.1 472054 473049 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; zinc-dependent hydrolase 472054..473049 Escherichia coli 55989 7148094 YP_002401556.1 CDS EC55989_0440 NC_011748.1 473105 473647 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acetyltransferase complement(473105..473647) Escherichia coli 55989 7144424 YP_002401557.1 CDS EC55989_0441 NC_011748.1 473631 474008 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(473631..474008) Escherichia coli 55989 7144425 YP_002401558.1 CDS cyoE NC_011748.1 474127 475017 R converts protoheme IX and farnesyl diphosphate to heme O; protoheme IX farnesyltransferase complement(474127..475017) Escherichia coli 55989 7144426 YP_002401559.1 CDS cyoD NC_011748.1 475029 475358 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 90366572, 92345252, 9378722, 98021084, 11017202, 2162835; Product type c : carrier; cytochrome o ubiquinol oxidase subunit IV complement(475029..475358) Escherichia coli 55989 7145819 YP_002401560.1 CDS cyoC NC_011748.1 475358 475972 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit III complement(475358..475972) Escherichia coli 55989 7145818 YP_002401561.1 CDS cyoB NC_011748.1 475962 477953 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330636, 92345252, 93349845, 9378722, 98021084, 11017202, 2162835, 2168206; Product type c : carrier; cytochrome o ubiquinol oxidase subunit I complement(475962..477953) Escherichia coli 55989 7145817 YP_002401562.1 CDS cyoA NC_011748.1 477975 478922 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92112945, 92371427, 9378722, 98021084, 11017202, 1322173, 2162835, 2162837, 2165491, 2168206, 8231804, 8618822; Product type c : carrier; cytochrome o ubiquinol oxidase subunit II complement(477975..478922) Escherichia coli 55989 7145816 YP_002401563.1 CDS ampG NC_011748.1 479382 480857 R in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein; muropeptide transporter complement(479382..480857) Escherichia coli 55989 7145815 YP_002401564.1 CDS yajG NC_011748.1 480901 481479 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein complement(480901..481479) Escherichia coli 55989 7145497 YP_002401565.1 CDS bolA NC_011748.1 481784 482101 D positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress; transcriptional regulator BolA 481784..482101 Escherichia coli 55989 7148089 YP_002401566.1 CDS tig NC_011748.1 482445 483743 D Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer; trigger factor 482445..483743 Escherichia coli 55989 7145635 YP_002401567.1 CDS clpP NC_011748.1 483989 484612 D hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates; ATP-dependent Clp protease proteolytic subunit 483989..484612 Escherichia coli 55989 7147801 YP_002401568.1 CDS clpX NC_011748.1 484738 486012 D binds and unfolds substrates as part of the ClpXP protease; ATP-dependent protease ATP-binding subunit ClpX 484738..486012 Escherichia coli 55989 7145724 YP_002401569.1 CDS lon NC_011748.1 486200 488554 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094703, 14665623, 8939438, 91072263, 97137085, 2984174, 3042779, 3289547, 7988699, 8226758, 8294008; Product type e : enzyme; DNA-binding ATP-dependent protease La 486200..488554 Escherichia coli 55989 7147698 YP_002401570.1 CDS hupB NC_011748.1 488763 489035 D histone-like DNA-binding protein; transcriptional regulator HU subunit beta 488763..489035 Escherichia coli 55989 7146720 YP_002401571.1 CDS ppiD NC_011748.1 489227 491098 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9670013; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase 489227..491098 Escherichia coli 55989 7146481 YP_002401572.1 CDS ybaV NC_011748.1 491249 491620 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 491249..491620 Escherichia coli 55989 7147231 YP_002401573.1 CDS ybaW NC_011748.1 491714 492112 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 491714..492112 Escherichia coli 55989 7148108 YP_002401574.1 CDS queC NC_011748.1 492164 492859 R YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His; queuosine biosynthesis protein QueC complement(492164..492859) Escherichia coli 55989 7148109 YP_002401575.1 CDS ybaE NC_011748.1 492924 494624 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(492924..494624) Escherichia coli 55989 7147332 YP_002401576.1 CDS cof NC_011748.1 494724 495542 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; thiamin pyrimidine pyrophosphate hydrolase 494724..495542 Escherichia coli 55989 7148097 YP_002401577.1 CDS ybaO NC_011748.1 495467 496153 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator (Lrp-like) 495467..496153 Escherichia coli 55989 7145741 YP_002401578.1 CDS mdlA NC_011748.1 496183 497955 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004, 10850996; Product type pt : transporter; multidrug transporter membrane\ATP-binding components 496183..497955 Escherichia coli 55989 7148103 YP_002401579.1 CDS mdlB NC_011748.1 497948 499729 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 94124004; Product type pt : transporter; multidrug transporter membrane\ATP-binding components 497948..499729 Escherichia coli 55989 7146795 YP_002401580.1 CDS glnK NC_011748.1 499910 500248 D indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia.; nitrogen regulatory protein P-II 2 499910..500248 Escherichia coli 55989 7146796 YP_002401581.1 CDS amtB NC_011748.1 500278 501564 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22020597, 9618533, 10931328, 1645722, 7984428; Product type t : transporter; ammonium transporter 500278..501564 Escherichia coli 55989 7146308 YP_002401582.1 CDS tesB NC_011748.1 501613 502473 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86139906, 91250410, 10876240; Product type e : enzyme; acyl-CoA thioesterase complement(501613..502473) Escherichia coli 55989 7145499 YP_002401583.1 CDS ybaY NC_011748.1 502691 503263 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; lipoprotein 502691..503263 Escherichia coli 55989 7147776 YP_002401584.1 CDS ybaZ NC_011748.1 503294 503683 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; methylated DNA-protein cysteine alkyltransferase complement(503294..503683) Escherichia coli 55989 7148110 YP_002401585.1 CDS ybaA NC_011748.1 503984 504337 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 503984..504337 Escherichia coli 55989 7146096 YP_002401586.1 CDS ylaB NC_011748.1 504379 505929 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(504379..505929) Escherichia coli 55989 7148095 YP_002401587.1 CDS ylaC NC_011748.1 506093 506563 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(506093..506563) Escherichia coli 55989 7149246 YP_002401588.1 CDS maa NC_011748.1 506679 507230 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82180540, 91310703, 9600841; Product type e : enzyme; maltose O-acetyltransferase complement(506679..507230) Escherichia coli 55989 7149247 YP_002401589.1 CDS hha NC_011748.1 507401 507865 R Evidence 2b : Function of strongly homologous gene; PubMedId : 1956303, 1484495; Product type f : factor; modulator of gene expression, with H-NS complement(507401..507865) Escherichia coli 55989 7146763 YP_002401590.1 CDS ybaJ NC_011748.1 507645 508019 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1956303, 7984428, 14645275; hypothetical protein complement(507645..508019) Escherichia coli 55989 7146426 YP_002401591.1 CDS acrB NC_011748.1 508565 511714 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12351840, 12654283, 15111118, 15155734, 21450803, 94012493, 10920254, 7651136; Product type t : transporter; multidrug efflux system protein complement(508565..511714) Escherichia coli 55989 7148098 YP_002401592.1 CDS acrA NC_011748.1 511737 512930 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155734, 21450803, 383699, 390095, 94012493, 10920254, 7651136; Product type t : transporter; multidrug efflux system complement(511737..512930) Escherichia coli 55989 7145445 YP_002401593.1 CDS acrR NC_011748.1 513072 513719 D regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine; DNA-binding transcriptional repressor AcrR 513072..513719 Escherichia coli 55989 7145444 YP_002401594.1 CDS kefA NC_011748.1 513847 517209 D small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS; potassium efflux protein KefA 513847..517209 Escherichia coli 55989 7145449 YP_002401595.1 CDS ybaM NC_011748.1 517421 517582 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(517421..517582) Escherichia coli 55989 7146666 YP_002401596.1 CDS priC NC_011748.1 517596 518123 R PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks; primosomal replication protein N'' complement(517596..518123) Escherichia coli 55989 7148101 YP_002401597.1 CDS ybaN NC_011748.1 518193 518570 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 518193..518570 Escherichia coli 55989 7147246 YP_002401598.1 CDS apt NC_011748.1 518723 519274 D catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis; adenine phosphoribosyltransferase 518723..519274 Escherichia coli 55989 7148102 YP_002401599.1 CDS dnaX NC_011748.1 519403 521334 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA; DNA polymerase III subunits gamma and tau 519403..521334 Escherichia coli 55989 7145511 YP_002401600.1 CDS ybaB NC_011748.1 521387 521716 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15322138, 1698765, 2674903; hypothetical protein 521387..521716 Escherichia coli 55989 7145942 YP_002401601.1 CDS recR NC_011748.1 521716 522321 D involved in a recombinational process of DNA repair, independent of the recBC complex; recombination protein RecR 521716..522321 Escherichia coli 55989 7148096 YP_002401602.1 CDS htpG NC_011748.1 522431 524305 D molecular chaperone; heat shock protein 90 522431..524305 Escherichia coli 55989 7147367 YP_002401603.1 CDS adk NC_011748.1 524486 525130 D essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP; adenylate kinase 524486..525130 Escherichia coli 55989 7146473 YP_002401604.1 CDS hemH NC_011748.1 525366 526328 D protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic; ferrochelatase 525366..526328 Escherichia coli 55989 7145460 YP_002401605.1 CDS aes NC_011748.1 526325 527284 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9401025, 98244813, 2051480, 7721718; Product type e : enzyme; acetyl esterase complement(526325..527284) Escherichia coli 55989 7146414 YP_002401606.1 CDS gsk NC_011748.1 527436 528740 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90155203, 95238302, 2051480; Product type e : enzyme; inosine/guanosine kinase 527436..528740 Escherichia coli 55989 7145464 YP_002401607.1 CDS ybaL NC_011748.1 528873 530549 R YbaL; member of the CPA-2 family of antiporters; uncharacterized protein; cation:proton antiport protein complement(528873..530549) Escherichia coli 55989 7146375 YP_002401608.1 CDS fsr NC_011748.1 530787 532007 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 97074653, 8917080; Product type t : transporter; fosmidomycin efflux system, member of the major facilitator superfamily complement(530787..532007) Escherichia coli 55989 7148100 YP_002401609.1 CDS ushA NC_011748.1 532225 533877 D catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides; bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic 532225..533877 Escherichia coli 55989 7146208 YP_002401610.1 CDS ybaK NC_011748.1 533914 534393 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(533914..534393) Escherichia coli 55989 7147574 YP_002401611.1 CDS ybaP NC_011748.1 534597 535391 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(534597..535391) Escherichia coli 55989 7147708 YP_002401612.1 CDS ybaQ NC_011748.1 535529 535870 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 535529..535870 Escherichia coli 55989 7148104 YP_002401613.1 CDS copA NC_011748.1 535984 538488 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12351646, 20105527, 11167016, 11500054, 9868784; Product type t : transporter; copper exporting ATPase complement(535984..538488) Escherichia coli 55989 7148105 YP_002401614.1 CDS ybaS NC_011748.1 538750 539682 D catalyzes the formation of glutamate from glutamine; glutaminase 538750..539682 Escherichia coli 55989 7145742 YP_002401615.1 CDS ybaT NC_011748.1 539685 540977 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; nitrogen-containing metabolite transporter 539685..540977 Escherichia coli 55989 7148106 YP_002401616.1 CDS cueR NC_011748.1 541102 541509 D activator of copper-responsive regulon genes; DNA-binding transcriptional regulator CueR 541102..541509 Escherichia coli 55989 7148107 YP_002401617.1 CDS ybbJ NC_011748.1 541510 541965 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(541510..541965) Escherichia coli 55989 7145789 YP_002401618.1 CDS ybbK NC_011748.1 541965 542882 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; protease, membrane anchored complement(541965..542882) Escherichia coli 55989 7148115 YP_002401619.1 CDS ybbL NC_011748.1 543028 543705 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; ABC transporter ATP-binding protein 543028..543705 Escherichia coli 55989 7148116 YP_002401620.1 CDS ybbM NC_011748.1 543692 544471 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; permease of an ABC transporter 543692..544471 Escherichia coli 55989 7148117 YP_002401621.1 CDS ybbN NC_011748.1 544534 545388 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; thioredoxin domain-containing protein complement(544534..545388) Escherichia coli 55989 7148118 YP_002401622.1 CDS ybbO NC_011748.1 545449 546258 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; short chain dehydrogenase complement(545449..546258) Escherichia coli 55989 7148119 YP_002401623.1 CDS tesA NC_011748.1 546248 546874 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91270121, 91324311, 93163029, 93252782, 94179121, 99353977, 1864840, 8432696, 8098033; Product type e : enzyme; multifunctional acyl-CoA thioesterase I/protease I/lysophospholipase L1 complement(546248..546874) Escherichia coli 55989 7148120 YP_002401624.1 CDS ybbA NC_011748.1 546842 547528 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; ABC transporter ATP-binding protein 546842..547528 Escherichia coli 55989 7147775 YP_002401625.1 CDS ybbP NC_011748.1 547525 549939 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type t : transporter; ABC transporter permease 547525..549939 Escherichia coli 55989 7148112 YP_002401626.1 CDS rhsD NC_011748.1 550369 554637 D Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 1766878, 2403547, 2644231, 7934896; Product type h : extrachromosomal origin; rhsD element protein 550369..554637 Escherichia coli 55989 7148121 YP_002401627.1 CDS insA NC_011748.1 554671 554946 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 554671..554946 Escherichia coli 55989 7147403 YP_002401628.1 CDS insB NC_011748.1 554865 555368 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 554865..555368 Escherichia coli 55989 7146569 YP_002401629.1 CDS ybbC NC_011748.1 555475 555843 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 555475..555843 Escherichia coli 55989 7146581 YP_002401630.1 CDS ylbH NC_011748.1 555843 556553 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1766878, 7934896; Product type h : extrachromosomal origin; rhs-like 555843..556553 Escherichia coli 55989 7148114 YP_002401631.1 CDS EC55989_0515 NC_011748.1 556534 557025 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 556534..557025 Escherichia coli 55989 7149251 YP_002401632.1 CDS EC55989_0516 NC_011748.1 557310 557525 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(557310..557525) Escherichia coli 55989 7144427 YP_002401633.1 CDS EC55989_0517 NC_011748.1 557512 557946 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; regulator with homeodomain-like DNA binding domain complement(557512..557946) Escherichia coli 55989 7144428 YP_002401634.1 CDS ybbB NC_011748.1 558026 559120 R catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA; tRNA 2-selenouridine synthase complement(558026..559120) Escherichia coli 55989 7144429 YP_002401635.1 CDS ybbS NC_011748.1 559189 560115 R activator of the allDC-ylbA operon involved in allantoin utilization; DNA-binding transcriptional activator AllS complement(559189..560115) Escherichia coli 55989 7148113 YP_002401636.1 CDS allA NC_011748.1 560345 560827 D catalyzes the formation of glyoxylate from (S)-ureidoglycolate; ureidoglycolate hydrolase 560345..560827 Escherichia coli 55989 7148122 YP_002401637.1 CDS allR NC_011748.1 560905 561720 D regulates operons involved in the utilization of allantoin; DNA-binding transcriptional repressor AllR 560905..561720 Escherichia coli 55989 7145483 YP_002401638.1 CDS gcl NC_011748.1 561810 563591 D catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate; glyoxylate carboligase 561810..563591 Escherichia coli 55989 7145487 YP_002401639.1 CDS hyi NC_011748.1 563604 564380 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20029625, 8440684; Product type e : enzyme; hydroxypyruvate isomerase 563604..564380 Escherichia coli 55989 7146272 YP_002401640.1 CDS glxR NC_011748.1 564480 565358 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme; tartronate semialdehyde reductase, NADH-dependent 564480..565358 Escherichia coli 55989 7146519 YP_002401641.1 CDS ybbW NC_011748.1 565527 566981 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1293888; Product type t : transporter; allantoin permease 565527..566981 Escherichia coli 55989 7146338 YP_002401642.1 CDS allB NC_011748.1 567041 568402 D Plays a crucial role on both purine and pyrimidine metabolism; allantoinase 567041..568402 Escherichia coli 55989 7148123 YP_002401643.1 CDS ybbY NC_011748.1 568459 569760 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; purine permease YbbY 568459..569760 Escherichia coli 55989 7145484 YP_002401644.1 CDS glxK NC_011748.1 569782 570927 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20069628; Product type e : enzyme; glycerate kinase 569782..570927 Escherichia coli 55989 7148124 YP_002401645.1 CDS ylbA NC_011748.1 571056 571841 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(571056..571841) Escherichia coli 55989 7146337 YP_002401646.1 CDS allC NC_011748.1 571852 573087 R allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide; allantoate amidohydrolase complement(571852..573087) Escherichia coli 55989 7149248 YP_002401647.1 CDS allD NC_011748.1 573109 574158 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12460564, 20069628, 69151449; Product type e : enzyme; ureidoglycolate dehydrogenase complement(573109..574158) Escherichia coli 55989 7145485 YP_002401648.1 CDS fdrA NC_011748.1 574475 576142 D multicopy suppressor of dominant negative ftsH mutations; membrane protein FdrA 574475..576142 Escherichia coli 55989 7145486 YP_002401649.1 CDS ylbE NC_011748.1 576152 577411 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 576152..577411 Escherichia coli 55989 7146075 YP_002401650.1 CDS ylbF NC_011748.1 577422 578237 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 577422..578237 Escherichia coli 55989 7149249 YP_002401651.1 CDS ybcF NC_011748.1 578234 579127 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2464576, 2644189, 7920643, 7940673, 7984428; Product type pe : enzyme; carbamate kinase 578234..579127 Escherichia coli 55989 7149250 YP_002401652.1 CDS purK NC_011748.1 579322 580389 R With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway; phosphoribosylaminoimidazole carboxylase ATPase subunit complement(579322..580389) Escherichia coli 55989 7148125 YP_002401653.1 CDS purE NC_011748.1 580386 580895 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10074353, 8117684, 89123018, 89123019, 92287929, 10574791; Product type e : enzyme; N5-carboxyaminoimidazole ribonucleotide mutase complement(580386..580895) Escherichia coli 55989 7147299 YP_002401654.1 CDS lpxH NC_011748.1 581013 581735 R catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine; UDP-2,3-diacylglucosamine hydrolase complement(581013..581735) Escherichia coli 55989 7147296 YP_002401655.1 CDS ppiB NC_011748.1 581738 582232 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 1864365, 8601841, 9298646, 9600841; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase B complement(581738..582232) Escherichia coli 55989 7146739 YP_002401656.1 CDS cysS NC_011748.1 582406 583791 D catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA; cysteinyl-tRNA synthetase 582406..583791 Escherichia coli 55989 7147229 YP_002401657.1 CDS ybcI NC_011748.1 583827 584348 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(583827..584348) Escherichia coli 55989 7145834 YP_002401658.1 CDS ybcJ NC_011748.1 584456 584668 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12837795, 1748668, 7567469; Product type pr : regulator; hypothetical protein complement(584456..584668) Escherichia coli 55989 7148127 YP_002401659.1 CDS folD NC_011748.1 584670 585536 R catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate; bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase complement(584670..585536) Escherichia coli 55989 7148128 YP_002401660.1 CDS sfmA NC_011748.1 586017 586559 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2890624; Product type ps : structure; fimbrial-like adhesin protein 586017..586559 Escherichia coli 55989 7146171 YP_002401661.1 CDS sfmC NC_011748.1 586779 587471 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15372038, 2553674; Product type f : factor; pilin chaperone, periplasmic 586779..587471 Escherichia coli 55989 7147640 YP_002401662.1 CDS sfmD NC_011748.1 587502 590111 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1970114; Product type pf : factor; outer membrane export usher protein 587502..590111 Escherichia coli 55989 7147641 YP_002401663.1 CDS sfmH NC_011748.1 590154 591131 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 590154..591131 Escherichia coli 55989 7147642 YP_002401664.1 CDS sfmF NC_011748.1 591142 591657 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2890624; Product type ps : structure; fimbrial protein 591142..591657 Escherichia coli 55989 7147644 YP_002401665.1 CDS fimZ NC_011748.1 591660 592292 R activates the production of the major fimbrae protein FimA; transcriptional regulator FimZ complement(591660..592292) Escherichia coli 55989 7147643 YP_002401666.1 CDS EC55989_0550 NC_011748.1 592541 592663 R Evidence 6 : Doubtful CDS; hypothetical protein complement(592541..592663) Escherichia coli 55989 7145383 YP_002401667.1 CDS envY NC_011748.1 592657 593418 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6317653, 2536924; Product type r : regulator; DNA-binding transcriptional activator of porin biosynthesis complement(592657..593418) Escherichia coli 55989 7144430 YP_002401668.1 CDS ybcH NC_011748.1 593601 594491 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(593601..594491) Escherichia coli 55989 7146007 YP_002401669.1 CDS nfrA NC_011748.1 594492 597464 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89359086, 94042873, 94042874; Product type m : membrane component; bacteriophage N4 receptor, outer membrane subunit complement(594492..597464) Escherichia coli 55989 7148126 YP_002401670.1 CDS nfrB NC_011748.1 597451 599688 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89359086, 94042873, 94042874; Product type m : membrane component; bacteriophage N4 adsorption protein B complement(597451..599688) Escherichia coli 55989 7146988 YP_002401671.1 CDS yhhI NC_011748.1 599957 601093 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ph : phenotype; transposase complement(599957..601093) Escherichia coli 55989 7146989 YP_002401672.1 CDS EC55989_0556 NC_011748.1 601197 601508 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(601197..601508) Escherichia coli 55989 7148980 YP_002401673.1 CDS EC55989_0557 NC_011748.1 601623 601874 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(601623..601874) Escherichia coli 55989 7144431 YP_002401674.1 CDS EC55989_0558 NC_011748.1 601871 606733 R Evidence 2b : Function of strongly homologous gene; PubMedId : 1766878, 2644231, 2403547, 7934896; Rhs core protein with extension complement(601871..606733) Escherichia coli 55989 7144432 YP_002401675.1 CDS EC55989_0559 NC_011748.1 606753 607214 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(606753..607214) Escherichia coli 55989 7144433 YP_002401676.1 CDS EC55989_0560 NC_011748.1 607242 609143 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9696756, 8557353; Rhs element Vgr protein complement(607242..609143) Escherichia coli 55989 7144434 YP_002401677.1 CDS cusS NC_011748.1 609880 611340 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 11283292, 11399769; Product type r : regulator; sensor kinase CusS complement(609880..611340) Escherichia coli 55989 7144435 YP_002401678.1 CDS cusR NC_011748.1 611318 612001 R response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR complement(611318..612001) Escherichia coli 55989 7145797 YP_002401679.1 CDS cusC NC_011748.1 612158 613540 D with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC 612158..613540 Escherichia coli 55989 7145795 YP_002401680.1 CDS cusF NC_011748.1 613564 613896 D Evidence 2b : Function of strongly homologous gene; PubMedId : 21125583, 11283292, 11399769, 12813074; Product type f : factor; copper-binding protein 613564..613896 Escherichia coli 55989 7145793 YP_002401681.1 CDS cusB NC_011748.1 613912 615135 D with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB 613912..615135 Escherichia coli 55989 7145794 YP_002401682.1 CDS cusA NC_011748.1 615147 618290 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 21125583, 21178899, 21450803, 11399769, 12813074, 1711024, 7984428; Product type t : transporter; copper/silver efflux system, membrane component 615147..618290 Escherichia coli 55989 7145792 YP_002401683.1 CDS pheP NC_011748.1 618392 619768 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91267923, 94042931, 8626334; Product type t : transporter; phenylalanine transporter 618392..619768 Escherichia coli 55989 7145790 YP_002401684.1 CDS ybdG NC_011748.1 619836 621083 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; membrane protein; channel complement(619836..621083) Escherichia coli 55989 7147160 YP_002401685.1 CDS nfnB NC_011748.1 621191 621844 R catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive; dihydropteridine reductase complement(621191..621844) Escherichia coli 55989 7148142 YP_002401686.1 CDS ybdF NC_011748.1 621938 622306 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(621938..622306) Escherichia coli 55989 7146986 YP_002401687.1 CDS ybdJ NC_011748.1 622371 622619 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(622371..622619) Escherichia coli 55989 7148141 YP_002401688.1 CDS ybdK NC_011748.1 622685 623803 R ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity; carboxylate-amine ligase complement(622685..623803) Escherichia coli 55989 7148144 YP_002401689.1 CDS hokE NC_011748.1 624245 624397 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99291074; Product type f : factor; toxic polypeptide, small 624245..624397 Escherichia coli 55989 7148145 YP_002401690.1 CDS entD NC_011748.1 625022 625651 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89313305, 90132534, 91035252, 8939709, 9214294; Product type e : enzyme; phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex complement(625022..625651) Escherichia coli 55989 7146452 YP_002401691.1 CDS fepA NC_011748.1 625817 628057 R Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space; outer membrane receptor FepA complement(625817..628057) Escherichia coli 55989 7146002 YP_002401692.1 CDS fes NC_011748.1 628378 629502 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92291125, 94198561, 2974033; Product type e : enzyme; enterobactin/ferric enterobactin esterase 628378..629502 Escherichia coli 55989 7146088 YP_002401693.1 CDS ybdZ NC_011748.1 629505 629723 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 629505..629723 Escherichia coli 55989 7146094 YP_002401694.1 CDS entF NC_011748.1 629720 633601 D with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin; enterobactin synthase subunit F 629720..633601 Escherichia coli 55989 7148149 YP_002401695.1 CDS fepE NC_011748.1 633817 634950 D part of the ferric enterobactin transport system; necessary for enetrobactin uptake; ferric enterobactin transport protein FepE 633817..634950 Escherichia coli 55989 7146004 YP_002401696.1 CDS fepC NC_011748.1 634947 635762 R with FepBDE is involved in the transport of ferric enterobactin; iron-enterobactin transporter ATP-binding protein complement(634947..635762) Escherichia coli 55989 7146092 YP_002401697.1 CDS fepG NC_011748.1 635759 636751 R with FepBCD is involved in the transport of ferric enterobactin; iron-enterobactin transporter permease complement(635759..636751) Escherichia coli 55989 7146090 YP_002401698.1 CDS fepD NC_011748.1 636748 637752 R with FepBCG is involved in the transport of ferric enterobactin; iron-enterobactin transporter membrane protein complement(636748..637752) Escherichia coli 55989 7146093 YP_002401699.1 CDS ybdA NC_011748.1 637863 639113 D protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters; enterobactin exporter EntS 637863..639113 Escherichia coli 55989 7146091 YP_002401700.1 CDS fepB NC_011748.1 639117 640073 R with FepCDG is involved in the transport of ferric enterobactin; iron-enterobactin transporter periplasmic binding protein complement(639117..640073) Escherichia coli 55989 7148138 YP_002401701.1 CDS entC NC_011748.1 640448 641623 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123153, 90165423, 90241936, 2110093, 2139473; Product type e : enzyme; isochorismate synthase 1 640448..641623 Escherichia coli 55989 7146089 YP_002401702.1 CDS entE NC_011748.1 641633 643243 D bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate; enterobactin synthase subunit E 641633..643243 Escherichia coli 55989 7146001 YP_002401703.1 CDS entB NC_011748.1 643257 644114 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20183918, 90241937, 91035252, 9485415, 97361959, 2521621, 2521622; Product type e : enzyme; isochorismatase 643257..644114 Escherichia coli 55989 7146003 YP_002401704.1 CDS entA NC_011748.1 644114 644860 D catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin; 2,3-dihydroxybenzoate-2,3-dehydrogenase 644114..644860 Escherichia coli 55989 7146000 YP_002401705.1 CDS ybdB NC_011748.1 644863 645276 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2521621, 2521622, 15808744; Product type pe : enzyme; hypothetical protein 644863..645276 Escherichia coli 55989 7145999 YP_002401706.1 CDS cstA NC_011748.1 645457 647562 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91162636, 2521622; Product type pf : factor; carbon starvation protein 645457..647562 Escherichia coli 55989 7148139 YP_002401707.1 CDS ybdD NC_011748.1 647744 647941 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 647744..647941 Escherichia coli 55989 7145787 YP_002401708.1 CDS ybdH NC_011748.1 647951 649039 R member of the iron-containing alcohol dehydrogenase family; unknown function; hypothetical protein complement(647951..649039) Escherichia coli 55989 7148140 YP_002401709.1 CDS ybdL NC_011748.1 649148 650308 D catalyzes the transfer of an amino moiety; aminotransferase 649148..650308 Escherichia coli 55989 7148143 YP_002401710.1 CDS ibrB NC_011748.1 650309 650938 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator complement(650309..650938) Escherichia coli 55989 7148146 YP_002401711.1 CDS ibrA NC_011748.1 650911 652131 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator complement(650911..652131) Escherichia coli 55989 7146535 YP_002401712.1 CDS ybdO NC_011748.1 652278 653180 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator, LysR-type complement(652278..653180) Escherichia coli 55989 7146533 YP_002401713.1 CDS dsbG NC_011748.1 653389 654135 R Involved in disulfide bond formation; disulfide isomerase/thiol-disulfide oxidase complement(653389..654135) Escherichia coli 55989 7148147 YP_002401714.1 CDS ahpC NC_011748.1 654507 655070 D with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate; alkyl hydroperoxide reductase 654507..655070 Escherichia coli 55989 7145953 YP_002401715.1 CDS ahpF NC_011748.1 655199 656764 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89197774, 1592833; Product type e : enzyme; alkyl hydroperoxide reductase 655199..656764 Escherichia coli 55989 7145474 YP_002401716.1 CDS uspG NC_011748.1 656885 657313 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12071968; Product type f : factor; universal stress protein UP12 complement(656885..657313) Escherichia coli 55989 7145475 YP_002401717.1 CDS ybdR NC_011748.1 657534 658772 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8185833; Product type pe : enzyme; oxidoreductase, Zn-dependent and NAD(P)-binding 657534..658772 Escherichia coli 55989 7147931 YP_002401718.1 CDS rnk NC_011748.1 659003 659413 R Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation; nucleoside diphosphate kinase regulator complement(659003..659413) Escherichia coli 55989 7148148 YP_002401719.1 CDS rna NC_011748.1 659643 660449 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90151658, 90264307, 2253883, 8188249; Product type e : enzyme; ribonuclease I complement(659643..660449) Escherichia coli 55989 7147452 YP_002401720.1 CDS citT NC_011748.1 660563 662026 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9696764; Product type t : transporter; citrate:succinate antiporter complement(660563..662026) Escherichia coli 55989 7147432 YP_002401721.1 CDS citG NC_011748.1 662077 662955 R catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA; triphosphoribosyl-dephospho-CoA synthase complement(662077..662955) Escherichia coli 55989 7145716 YP_002401722.1 CDS citX NC_011748.1 662930 663481 R 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate; 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase complement(662930..663481) Escherichia coli 55989 7145715 YP_002401723.1 CDS citF NC_011748.1 663485 665017 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citrate-ACP transferase (alpha) subunit complement(663485..665017) Escherichia coli 55989 7145717 YP_002401724.1 CDS citE NC_011748.1 665028 665936 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase, citryl-ACP lyase (beta) subunit complement(665028..665936) Escherichia coli 55989 7145714 YP_002401725.1 CDS citD NC_011748.1 665933 666229 R acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate; citrate lyase subunit gamma complement(665933..666229) Escherichia coli 55989 7145713 YP_002401726.1 CDS citC NC_011748.1 666244 667302 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 84024606, 87214225; Product type e : enzyme; citrate lyase synthetase complement(666244..667302) Escherichia coli 55989 7145712 YP_002401727.1 CDS citA NC_011748.1 667682 669340 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11889485, 21885746, 9701802; Product type r : regulator; sensory histidine kinase in two-component regulatory system with citB 667682..669340 Escherichia coli 55989 7145711 YP_002401728.1 CDS dpiA NC_011748.1 669309 669989 D regulates the expression of citAB in citrate fermentation; two-component response regulator DpiA 669309..669989 Escherichia coli 55989 7145709 YP_002401729.1 CDS dcuC NC_011748.1 670030 671415 R responsible for the transport of C4-dicarboxylates during anaerobic growth; C4-dicarboxylate transporter DcuC complement(670030..671415) Escherichia coli 55989 7145710 YP_002401730.1 CDS pagP NC_011748.1 672004 672564 D catalyzes the transfer of palmitate to lipid A; palmitoyl transferase 672004..672564 Escherichia coli 55989 7145862 YP_002401731.1 CDS cspE NC_011748.1 672739 672948 D member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator; cold shock protein CspE 672739..672948 Escherichia coli 55989 7145751 YP_002401732.1 CDS crcB NC_011748.1 673002 673385 R may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling; camphor resistance protein CrcB complement(673002..673385) Escherichia coli 55989 7145780 YP_002401733.1 CDS ybeM NC_011748.1 673703 674266 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; amidase 673703..674266 Escherichia coli 55989 7145752 YP_002401734.1 CDS tatE NC_011748.1 674395 674598 D TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein E 674395..674598 Escherichia coli 55989 7148155 YP_002401735.1 CDS lipA NC_011748.1 674699 675664 R catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group; lipoyl synthase complement(674699..675664) Escherichia coli 55989 7147757 YP_002401736.1 CDS ybeF NC_011748.1 675873 676826 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12218038; Product type pr : regulator; DNA-binding transcriptional regulator complement(675873..676826) Escherichia coli 55989 7146703 YP_002401737.1 CDS lipB NC_011748.1 677085 677726 R lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein; lipoate-protein ligase B complement(677085..677726) Escherichia coli 55989 7148153 YP_002401738.1 CDS ybeD NC_011748.1 677827 678090 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8444795; hypothetical protein complement(677827..678090) Escherichia coli 55989 7146704 YP_002401739.1 CDS dacA NC_011748.1 678201 679412 R penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; D-alanyl-D-alanine carboxypeptidase complement(678201..679412) Escherichia coli 55989 7148152 YP_002401740.1 CDS rlpA NC_011748.1 679551 680639 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88058785, 2644207; Product type lp : lipoprotein; rare lipoprotein A complement(679551..680639) Escherichia coli 55989 7145841 YP_002401741.1 CDS mrdB NC_011748.1 680650 681762 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89123070, 90036736, 91072213, 3316191; Product type cp : cell process; cell wall shape-determining protein complement(680650..681762) Escherichia coli 55989 7147424 YP_002401742.1 CDS mrdA NC_011748.1 681765 683666 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86196149, 87030266, 89174517, 2644207; Product type e : enzyme; penicillin-binding protein 2 complement(681765..683666) Escherichia coli 55989 7146901 YP_002401743.1 CDS ybeA NC_011748.1 683697 684164 R SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA; rRNA large subunit methyltransferase complement(683697..684164) Escherichia coli 55989 7146900 YP_002401744.1 CDS ybeB NC_011748.1 684168 684485 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(684168..684485) Escherichia coli 55989 7148150 YP_002401745.1 CDS phpB NC_011748.1 684746 685357 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7929373; Product type pe : enzyme; phosphatase with phosphoglycerate mutase domain complement(684746..685357) Escherichia coli 55989 7148151 YP_002401746.1 CDS nadD NC_011748.1 685381 686022 R transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria; nicotinic acid mononucleotide adenylyltransferase complement(685381..686022) Escherichia coli 55989 7147188 YP_002401747.1 CDS holA NC_011748.1 686024 687055 R required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA; DNA polymerase III subunit delta complement(686024..687055) Escherichia coli 55989 7146945 YP_002401748.1 CDS rlpB NC_011748.1 687055 687636 R rare lipoprotein B; involved in the assembly of LPS in the outer membrane; LPS-assembly lipoprotein RlpB complement(687055..687636) Escherichia coli 55989 7146453 YP_002401749.1 CDS leuS NC_011748.1 687651 690233 R leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase; leucyl-tRNA synthetase complement(687651..690233) Escherichia coli 55989 7147425 YP_002401750.1 CDS ybeL NC_011748.1 690468 690950 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11373298, 12105207, 3320963, 7567469; hypothetical protein 690468..690950 Escherichia coli 55989 7146695 YP_002401751.1 CDS ybeQ NC_011748.1 691020 691997 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(691020..691997) Escherichia coli 55989 7148154 YP_002401752.1 CDS ybeR NC_011748.1 692161 692868 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 692161..692868 Escherichia coli 55989 7148156 YP_002401753.1 CDS djlB NC_011748.1 692865 694292 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12183460, 10574456; Product type pf : factor; DnaJ-class chaperone 692865..694292 Escherichia coli 55989 7148157 YP_002401754.1 CDS ybeT NC_011748.1 694302 694856 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; outer membrane protein complement(694302..694856) Escherichia coli 55989 7145922 YP_002401755.1 CDS ybeU NC_011748.1 694957 695664 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 694957..695664 Escherichia coli 55989 7148158 YP_002401756.1 CDS djlC NC_011748.1 695661 697112 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12183460, 12054669; Product type f : factor; Hsc56 co-chaperone of HscC 695661..697112 Escherichia coli 55989 7148159 YP_002401757.1 CDS EC55989_0643 NC_011748.1 698876 700084 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L 698876..700084 Escherichia coli 55989 7147440 YP_002401758.1 CDS rihA NC_011748.1 700264 701199 R Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific; ribonucleoside hydrolase 1 complement(700264..701199) Escherichia coli 55989 7146464 YP_002401759.1 CDS gltL NC_011748.1 701317 702042 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate transporter subunit ; ATP-binding component of ABC superfamily complement(701317..702042) Escherichia coli 55989 7147415 YP_002401760.1 CDS gltK NC_011748.1 702042 702716 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate transporter subunit ; membrane component of ABC superfamily complement(702042..702716) Escherichia coli 55989 7146333 YP_002401761.1 CDS gltJ NC_011748.1 702716 703456 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11121068; Product type t : transporter; glutamate and aspartate transporter subunit ; membrane component of ABC superfamily complement(702716..703456) Escherichia coli 55989 7146332 YP_002401762.1 CDS gltI NC_011748.1 703626 704534 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1091636, 1091635, 10493123, 8740179, 10972807; Product type t : transporter; glutamate and aspartate transporter subunit complement(703626..704534) Escherichia coli 55989 7145301 YP_002401763.1 CDS lnt NC_011748.1 706943 708481 R Transfers the fatty acyl group on membrane lipoproteins; apolipoprotein N-acyltransferase complement(706943..708481) Escherichia coli 55989 7144438 YP_002401764.1 CDS ybeX NC_011748.1 708506 709384 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1779764; Product type pt : transporter; protein involved in divalent ion export complement(708506..709384) Escherichia coli 55989 7146714 YP_002401765.1 CDS ybeY NC_011748.1 709474 709941 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16511207; Product type pe : enzyme; metalloprotease complement(709474..709941) Escherichia coli 55989 7148160 YP_002401766.1 CDS ybeZ NC_011748.1 709938 711017 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12762842; Product type pe : enzyme; enzyme with nucleoside triphosphate hydrolase domain complement(709938..711017) Escherichia coli 55989 7148161 YP_002401767.1 CDS miaB NC_011748.1 711131 712555 R catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A); (dimethylallyl)adenosine tRNA methylthiotransferase complement(711131..712555) Escherichia coli 55989 7148162 YP_002401768.1 CDS ubiF NC_011748.1 712701 713876 D catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q; 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase 712701..713876 Escherichia coli 55989 7146853 YP_002401769.1 CDS asnB NC_011748.1 715114 716778 R functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP; asparagine synthetase B complement(715114..716778) Escherichia coli 55989 7145403 YP_002401770.1 CDS nagD NC_011748.1 717035 717787 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16430214, 89343637; Product type e : enzyme; UMP phosphatase complement(717035..717787) Escherichia coli 55989 7145568 YP_002401771.1 CDS nagC NC_011748.1 717835 719055 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15066032, 90136533, 91171292, 92114782, 92356048, 2190615, 2668691, 7545108; Product type r : regulator; DNA-binding transcriptional dual regulator complement(717835..719055) Escherichia coli 55989 7146951 YP_002401772.1 CDS nagA NC_011748.1 719064 720212 R catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate; N-acetylglucosamine-6-phosphate deacetylase complement(719064..720212) Escherichia coli 55989 7146950 YP_002401773.1 CDS nagB NC_011748.1 720272 721072 R catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate; glucosamine-6-phosphate deaminase complement(720272..721072) Escherichia coli 55989 7146948 YP_002401774.1 CDS nagE NC_011748.1 721405 723351 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system N-acetyl glucosamine specific transporter subunit IIABC 721405..723351 Escherichia coli 55989 7146949 YP_002401775.1 CDS glnS NC_011748.1 723554 725218 D catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; glutaminyl-tRNA synthetase 723554..725218 Escherichia coli 55989 7146952 YP_002401776.1 CDS ybfM NC_011748.1 725664 727070 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2118530, 9636669; Product type pt : transporter; outer membrane porin 725664..727070 Escherichia coli 55989 7146312 YP_002401777.1 CDS ybfN NC_011748.1 727120 727446 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; lipoprotein 727120..727446 Escherichia coli 55989 7148168 YP_002401778.1 CDS fur NC_011748.1 727530 727976 R negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer; ferric uptake regulator complement(727530..727976) Escherichia coli 55989 7148169 YP_002401779.1 CDS EC55989_0670 NC_011748.1 728021 728275 D Evidence 6 : Doubtful CDS; hypothetical protein 728021..728275 Escherichia coli 55989 7146233 YP_002401780.1 CDS fldA NC_011748.1 728265 728795 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin FldA complement(728265..728795) Escherichia coli 55989 7144439 YP_002401781.1 CDS ybfE NC_011748.1 728935 729228 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20223640, 12427949; Product type cp : cell process; LexA regulated protein complement(728935..729228) Escherichia coli 55989 7146122 YP_002401782.1 CDS ybfF NC_011748.1 729368 730132 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : enzyme; hypothetical protein complement(729368..730132) Escherichia coli 55989 7148166 YP_002401783.1 CDS seqA NC_011748.1 730317 730862 D negative modulator of the initiation of chromosome replication; replication initiation regulator SeqA 730317..730862 Escherichia coli 55989 7148167 YP_002401784.1 CDS pgm NC_011748.1 730888 732528 D catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate; phosphoglucomutase 730888..732528 Escherichia coli 55989 7147631 YP_002401785.1 CDS potE NC_011748.1 732584 733903 R catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system; putrescine transporter complement(732584..733903) Escherichia coli 55989 7147153 YP_002401786.1 CDS speF NC_011748.1 733900 736098 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92041955; Product type e : enzyme; ornithine decarboxylase complement(733900..736098) Escherichia coli 55989 7147213 YP_002401787.1 CDS kdpE NC_011748.1 736788 737465 R response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport; DNA-binding transcriptional activator KdpE complement(736788..737465) Escherichia coli 55989 7147690 YP_002401788.1 CDS kdpD NC_011748.1 737462 740146 R sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein; sensor protein KdpD complement(737462..740146) Escherichia coli 55989 7146658 YP_002401789.1 CDS kdpC NC_011748.1 740139 740711 R One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex; potassium-transporting ATPase subunit C complement(740139..740711) Escherichia coli 55989 7146657 YP_002401790.1 CDS kdpB NC_011748.1 740720 742768 R One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit B complement(740720..742768) Escherichia coli 55989 7146656 YP_002401791.1 CDS kdpA NC_011748.1 742791 744464 R catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions; potassium-transporting ATPase subunit A complement(742791..744464) Escherichia coli 55989 7146655 YP_002401792.1 CDS ybfA NC_011748.1 744866 745072 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 744866..745072 Escherichia coli 55989 7146654 YP_002401793.1 CDS rhsC NC_011748.1 745315 749508 D Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 2403547, 2644231, 7934896, 8387990; Product type h : extrachromosomal origin; rhsC element core protein RshC 745315..749508 Escherichia coli 55989 7148163 YP_002401794.1 CDS ybfB NC_011748.1 749508 749834 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 749508..749834 Escherichia coli 55989 7147402 YP_002401795.1 CDS ybfO NC_011748.1 749952 751385 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; rhs-like 749952..751385 Escherichia coli 55989 7148164 YP_002401796.1 CDS ybfC NC_011748.1 751382 751951 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 751382..751951 Escherichia coli 55989 7148170 YP_002401797.1 CDS ybgA NC_011748.1 753466 753975 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6325460, 8387990; hypothetical protein 753466..753975 Escherichia coli 55989 7148982 YP_002401798.1 CDS phr NC_011748.1 753972 755390 D UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent; deoxyribodipyrimidine photolyase 753972..755390 Escherichia coli 55989 7148171 YP_002401799.1 CDS ybgH NC_011748.1 755432 756913 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15175316; Product type pt : transporter; transporter complement(755432..756913) Escherichia coli 55989 7147189 YP_002401800.1 CDS ybgI NC_011748.1 757184 757927 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14519207; hydrolase-oxidase 757184..757927 Escherichia coli 55989 7148175 YP_002401801.1 CDS ybgJ NC_011748.1 757950 758606 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase subunit 757950..758606 Escherichia coli 55989 7148176 YP_002401802.1 CDS ybgK NC_011748.1 758600 759532 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase subunit 758600..759532 Escherichia coli 55989 7148177 YP_002401803.1 CDS ybgL NC_011748.1 759522 760256 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1729609; Product type pe : enzyme; LamB/YcsF family protein 759522..760256 Escherichia coli 55989 7148178 YP_002401804.1 CDS nei NC_011748.1 760292 761083 D 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity; endonuclease VIII 760292..761083 Escherichia coli 55989 7148179 YP_002401805.1 CDS abrB NC_011748.1 761080 762126 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8002588; Product type ph : phenotype; hypothetical protein complement(761080..762126) Escherichia coli 55989 7146983 YP_002401806.1 CDS ybgO NC_011748.1 762278 763339 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(762278..763339) Escherichia coli 55989 7145427 YP_002401807.1 CDS ybgP NC_011748.1 763336 764091 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10049807; Product type pf : factor; chaperone, PapD family complement(763336..764091) Escherichia coli 55989 7148180 YP_002401808.1 CDS ybgQ NC_011748.1 764082 766583 R Evidence 4 : Homologs of previously reported genes of unknown function; outer membrane protein complement(764082..766583) Escherichia coli 55989 7148181 YP_002401809.1 CDS EC55989_0702 NC_011748.1 766592 767158 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; fimbrial-like adhesin protein complement(766592..767158) Escherichia coli 55989 7148182 YP_002401810.1 CDS gltA NC_011748.1 767548 768831 R type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH; type II citrate synthase complement(767548..768831) Escherichia coli 55989 7144440 YP_002401811.1 CDS EC55989_0704 NC_011748.1 769037 769195 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(769037..769195) Escherichia coli 55989 7146327 YP_002401812.1 CDS sdhC NC_011748.1 769540 769929 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6237244, 89076355, 89123360, 9521736, 99414342, 11259408, 3309132, 6383359, 9822661; Product type m : membrane component; succinate dehydrogenase cytochrome b556 large membrane subunit 769540..769929 Escherichia coli 55989 7144441 YP_002401813.1 CDS sdhD NC_011748.1 769923 770270 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82124790, 89076355, 9521736, 99414342, 6383359; Product type m : membrane component; succinate dehydrogenase cytochrome b556 small membrane subunit 769923..770270 Escherichia coli 55989 7147617 YP_002401814.1 CDS sdhA NC_011748.1 770270 772036 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; succinate dehydrogenase flavoprotein subunit 770270..772036 Escherichia coli 55989 7147618 YP_002401815.1 CDS sdhB NC_011748.1 772052 772768 D part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase; succinate dehydrogenase iron-sulfur subunit 772052..772768 Escherichia coli 55989 7147615 YP_002401816.1 CDS sucA NC_011748.1 772969 775770 D SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide; 2-oxoglutarate dehydrogenase E1 772969..775770 Escherichia coli 55989 7147616 YP_002401817.1 CDS sucB NC_011748.1 775785 777002 D component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA; dihydrolipoamide succinyltransferase 775785..777002 Escherichia coli 55989 7147726 YP_002401818.1 CDS sucC NC_011748.1 777096 778262 D catalyzes the interconversion of succinyl-CoA and succinate; succinyl-CoA synthetase subunit beta 777096..778262 Escherichia coli 55989 7147727 YP_002401819.1 CDS sucD NC_011748.1 778262 779131 D Catalyzes the only substrate-level phosphorylation in the TCA cycle; succinyl-CoA synthetase subunit alpha 778262..779131 Escherichia coli 55989 7147728 YP_002401820.1 CDS mngR NC_011748.1 779235 779957 R regulates the succiny-lCoA synthetase operon; DNA-binding transcriptional repressor MngR complement(779235..779957) Escherichia coli 55989 7147575 YP_002401821.1 CDS mngA NC_011748.1 780066 782042 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC 780066..782042 Escherichia coli 55989 7146869 YP_002401822.1 CDS mngB NC_011748.1 782060 784693 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14645248, 9063979; Product type e : enzyme; alpha-mannosidase 782060..784693 Escherichia coli 55989 7146867 YP_002401823.1 CDS EC55989_0716 NC_011748.1 784718 784945 D Evidence 6 : Doubtful CDS; hypothetical protein 784718..784945 Escherichia coli 55989 7146868 YP_002401824.1 CDS cydA NC_011748.1 785540 787108 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 1689724, 1724280, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase, subunit I 785540..787108 Escherichia coli 55989 7144442 YP_002401825.1 CDS cydB NC_011748.1 787124 788263 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87299685, 89255232, 91035243, 2843510, 3138232; Product type c : carrier; cytochrome d terminal oxidase, subunit II 787124..788263 Escherichia coli 55989 7145807 YP_002401826.1 CDS ybgE NC_011748.1 788391 788684 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 788391..788684 Escherichia coli 55989 7145808 YP_002401827.1 CDS ybgC NC_011748.1 788834 789238 D catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components; acyl-CoA thioester hydrolase 788834..789238 Escherichia coli 55989 7148173 YP_002401828.1 CDS tolQ NC_011748.1 789235 789927 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolQ 789235..789927 Escherichia coli 55989 7148172 YP_002401829.1 CDS tolR NC_011748.1 789931 790359 D membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins; colicin uptake protein TolR 789931..790359 Escherichia coli 55989 7147815 YP_002401830.1 CDS tolA NC_011748.1 790424 791689 D inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins; cell envelope integrity inner membrane protein TolA 790424..791689 Escherichia coli 55989 7147816 YP_002401831.1 CDS tolB NC_011748.1 791822 793114 D forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA; translocation protein TolB 791822..793114 Escherichia coli 55989 7147811 YP_002401832.1 CDS pal NC_011748.1 793149 793670 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790745, 87133578, 92244043, 99403391, 11173492, 2687247; Product type lp : lipoprotein; peptidoglycan-associated outer membrane lipoprotein 793149..793670 Escherichia coli 55989 7147813 YP_002401833.1 CDS ybgF NC_011748.1 793680 794471 D periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity; tol-pal system protein YbgF 793680..794471 Escherichia coli 55989 7147109 YP_002401834.1 CDS nadA NC_011748.1 795940 796983 D 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate; quinolinate synthetase 795940..796983 Escherichia coli 55989 7145322 YP_002401835.1 CDS pnuC NC_011748.1 797021 797740 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 219824, 90330519; Product type t : transporter; nicotinamide mononucleotide transporter 797021..797740 Escherichia coli 55989 7146942 YP_002401836.1 CDS zitB NC_011748.1 797737 798678 R involved in zinc efflux across the cytoplasmic membrane; zinc transporter ZitB complement(797737..798678) Escherichia coli 55989 7147206 YP_002401837.1 CDS ybgS NC_011748.1 798792 799172 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(798792..799172) Escherichia coli 55989 7149489 YP_002401838.1 CDS aroG NC_011748.1 799488 800540 D catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase 799488..800540 Escherichia coli 55989 7148183 YP_002401839.1 CDS gpmA NC_011748.1 800698 801450 R 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate; phosphoglyceromutase complement(800698..801450) Escherichia coli 55989 7145545 YP_002401840.1 CDS galM NC_011748.1 801655 802695 R catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose; aldose 1-epimerase complement(801655..802695) Escherichia coli 55989 7146360 YP_002401841.1 CDS galK NC_011748.1 802689 803837 R catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism; galactokinase complement(802689..803837) Escherichia coli 55989 7146250 YP_002401842.1 CDS galT NC_011748.1 803841 804887 R catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P; galactose-1-phosphate uridylyltransferase complement(803841..804887) Escherichia coli 55989 7146249 YP_002401843.1 CDS galE NC_011748.1 804897 805913 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89274199, 92253563, 92338916, 3022232, 6301942, 8564363, 8611559, 8931134, 9174344, 9271499, 9708982; Product type e : enzyme; UDP-galactose-4-epimerase complement(804897..805913) Escherichia coli 55989 7146254 YP_002401844.1 CDS modF NC_011748.1 806174 807646 R contains 2 ATP-binding cassettes; involved in the transport of molybdenum; molybdenum transport ATP-binding protein ModF complement(806174..807646) Escherichia coli 55989 7146247 YP_002401845.1 CDS EC55989_0740 NC_011748.1 807574 807720 R Evidence 6 : Doubtful CDS; hypothetical protein complement(807574..807720) Escherichia coli 55989 7146883 YP_002401846.1 CDS modE NC_011748.1 807714 808502 R represses the modABCD operon and activates the moaABCD and napFDAGHBC operons; DNA-binding transcriptional regulator ModE complement(807714..808502) Escherichia coli 55989 7144443 YP_002401847.1 CDS ybhT NC_011748.1 808631 808780 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 808631..808780 Escherichia coli 55989 7146882 YP_002401848.1 CDS modA NC_011748.1 808947 809720 D with ModCB is involved in the high-affinity transport of molybdate; molybdate transporter periplasmic protein 808947..809720 Escherichia coli 55989 7148202 YP_002401849.1 CDS modB NC_011748.1 809720 810409 D part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE; molybdate ABC transporter permease 809720..810409 Escherichia coli 55989 7146879 YP_002401850.1 CDS modC NC_011748.1 810412 811470 D Part of the ABC transporter complex modABC involved in molybdenum import; molybdate transporter ATP-binding protein 810412..811470 Escherichia coli 55989 7146880 YP_002401851.1 CDS ybhA NC_011748.1 811471 812289 R YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily; phosphotransferase complement(811471..812289) Escherichia coli 55989 7146881 YP_002401852.1 CDS pgl NC_011748.1 812444 813439 D catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate; 6-phosphogluconolactonase 812444..813439 Escherichia coli 55989 7148184 YP_002401853.1 CDS insA NC_011748.1 814238 814513 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 814238..814513 Escherichia coli 55989 7148187 YP_002401854.1 CDS insB NC_011748.1 814432 814935 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 814432..814935 Escherichia coli 55989 7146570 YP_002401855.1 CDS ybhI NC_011748.1 815697 817130 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; anion transporter 815697..817130 Escherichia coli 55989 7148190 YP_002401856.1 CDS ybhJ NC_011748.1 817313 819574 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11782506; Product type pe : enzyme; hypothetical protein 817313..819574 Escherichia coli 55989 7148191 YP_002401857.1 CDS ybhC NC_011748.1 819808 821091 R outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family; pectinesterase complement(819808..821091) Escherichia coli 55989 7148192 YP_002401858.1 CDS int NC_011748.1 821226 822296 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6446713; Product type h : extrachromosomal origin; Integrase from phage complement(821226..822296) Escherichia coli 55989 7148186 YP_002401859.1 CDS EC55989_0757 NC_011748.1 822920 823123 D hypothetical protein 822920..823123 Escherichia coli 55989 7146602 YP_002401860.1 CDS EC55989_0758 NC_011748.1 823755 823976 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(823755..823976) Escherichia coli 55989 7144444 YP_002401861.1 CDS EC55989_0759 NC_011748.1 824075 824386 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(824075..824386) Escherichia coli 55989 7144445 YP_002401862.1 CDS EC55989_0761 NC_011748.1 824367 824558 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein complement(824367..824558) Escherichia coli 55989 7144446 YP_002401863.1 CDS EC55989_0762 NC_011748.1 824710 825390 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; exonuclease from phage origin complement(824710..825390) Escherichia coli 55989 7144447 YP_002401864.1 CDS EC55989_0763 NC_011748.1 825387 826172 R Evidence 2b : Function of strongly homologous gene; PubMedId : 6458018, 6221115; Product type h : extrachromosomal origin; Recombination protein bet from phage origin complement(825387..826172) Escherichia coli 55989 7144448 YP_002401865.1 CDS EC55989_0764 NC_011748.1 826178 826474 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; host-nuclease inhibitor protein Gam of bacteriophage complement(826178..826474) Escherichia coli 55989 7144449 YP_002401866.1 CDS EC55989_0766 NC_011748.1 827354 828109 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Regulatory protein CI from bacteriophage origin complement(827354..828109) Escherichia coli 55989 7144451 YP_002401867.1 CDS cro NC_011748.1 828148 828378 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Cro 828148..828378 Escherichia coli 55989 7144452 YP_002401868.1 CDS EC55989_0768 NC_011748.1 828448 828987 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 612476; Product type h : extrachromosomal origin; Regulatory protein CII (modular protein) from bacteriophage origin; coiled-coil 828448..828987 Escherichia coli 55989 7145758 YP_002401869.1 CDS EC55989_0769 NC_011748.1 828984 830003 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2995831; Product type h : extrachromosomal origin; Replication protein O frm phage origin 828984..830003 Escherichia coli 55989 7144453 YP_002401870.1 CDS EC55989_0770 NC_011748.1 830000 830701 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; replication protein P of bacteriophage 830000..830701 Escherichia coli 55989 7144454 YP_002401871.1 CDS EC55989_0771 NC_011748.1 830698 831000 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Ren protein from phage origin 830698..831000 Escherichia coli 55989 7144455 YP_002401872.1 CDS emrE NC_011748.1 831068 831400 D member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein 831068..831400 Escherichia coli 55989 7144456 YP_002401873.1 CDS ybcK NC_011748.1 831656 833182 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; site-specific invertase; DLP12 prophage 831656..833182 Escherichia coli 55989 7145992 YP_002401874.1 CDS EC55989_0774 NC_011748.1 833179 833355 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 833179..833355 Escherichia coli 55989 7148129 YP_002401875.1 CDS EC55989_0776 NC_011748.1 833852 834361 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 833852..834361 Escherichia coli 55989 7144458 YP_002401876.1 CDS ybcN NC_011748.1 834556 835011 D DLP12 prophage; hypothetical protein 834556..835011 Escherichia coli 55989 7144459 YP_002401877.1 CDS ninE NC_011748.1 835011 835181 D DLP12 prophage; conserved protein similar to phage 82 and lambda proteins; prophage protein NinE 835011..835181 Escherichia coli 55989 7148132 YP_002401878.1 CDS ybcO NC_011748.1 835174 835464 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; DLP12 prophage 835174..835464 Escherichia coli 55989 7147001 YP_002401879.1 CDS ybcQ NC_011748.1 836045 836428 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8648624, 9278503; Product type pf : factor; antitermination protein Q 836045..836428 Escherichia coli 55989 7147559 YP_002401880.1 CDS nmpC NC_011748.1 836617 837699 R Evidence 2b : Function of strongly homologous gene; PubMedId : 3017988, 8057841; Product type m : membrane component; outer membrane porin; DLP12 prophage complement(836617..837699) Escherichia coli 55989 7148134 YP_002401881.1 CDS essD NC_011748.1 838288 838503 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : enzyme; phage lysis protein S; DLP12 prophage 838288..838503 Escherichia coli 55989 7147012 YP_002401882.1 CDS ybcS NC_011748.1 838503 839000 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3017988; Product type pe : enzyme; lysozyme; DLP12 prophage 838503..839000 Escherichia coli 55989 7146023 YP_002401883.1 CDS EC55989_0785 NC_011748.1 838985 839434 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; bacteriophage lysis protein 838985..839434 Escherichia coli 55989 7148135 YP_002401884.1 CDS EC55989_0786 NC_011748.1 839640 840161 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 839640..840161 Escherichia coli 55989 7144460 YP_002401885.1 CDS EC55989_0787 NC_011748.1 840511 840936 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein complement(840511..840936) Escherichia coli 55989 7144461 YP_002401886.1 CDS ynfO NC_011748.1 840978 841211 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage complement(840978..841211) Escherichia coli 55989 7144462 YP_002401887.1 CDS nohB NC_011748.1 841600 842145 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92334985; Product type h : extrachromosomal origin; DNA packaging protein; DLP12 prophage 841600..842145 Escherichia coli 55989 7149321 YP_002401888.1 CDS A NC_011748.1 842120 843781 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Terminase large subunit from bacteriophage origin 842120..843781 Escherichia coli 55989 7147013 YP_002401889.1 CDS W NC_011748.1 844041 844247 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11302702; Product type h : extrachromosomal origin; Head-to-tail joining protein W (gpW) from bacteriophage origin 844041..844247 Escherichia coli 55989 7144463 YP_002401890.1 CDS B NC_011748.1 844244 845845 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Portal protein; minor capsid protein [Contains: Protein B*] from bacteriophage origin 844244..845845 Escherichia coli 55989 7147954 YP_002401891.1 CDS C NC_011748.1 845691 847145 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; Minor capsid protein C from bacteriophage origin 845691..847145 Escherichia coli 55989 7145591 YP_002401892.1 CDS D NC_011748.1 847149 847487 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Head decoration protein from bacteriophage origin 847149..847487 Escherichia coli 55989 7145645 YP_002401893.1 CDS E NC_011748.1 847516 848568 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Major head coat protein from bacteriophage origin 847516..848568 Escherichia coli 55989 7145839 YP_002401894.1 CDS fI NC_011748.1 848571 849005 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; DNA packaging protein from bacteriophage origin 848571..849005 Escherichia coli 55989 7145965 YP_002401895.1 CDS fII NC_011748.1 849017 849370 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 6221115; Product type h : extrachromosomal origin; Tail attachment protein (Minor capsid protein FII) from bacteriophage origin 849017..849370 Escherichia coli 55989 7146105 YP_002401896.1 CDS EC55989_0799 NC_011748.1 849382 849960 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein Z (GpZ) 849382..849960 Escherichia coli 55989 7146109 YP_002401897.1 CDS EC55989_0800 NC_011748.1 849957 850352 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein U 849957..850352 Escherichia coli 55989 7144464 YP_002401898.1 CDS EC55989_0801 NC_011748.1 850330 851100 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail protein V 850330..851100 Escherichia coli 55989 7144465 YP_002401899.1 CDS EC55989_0802 NC_011748.1 851116 851538 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein G 851116..851538 Escherichia coli 55989 7144466 YP_002401900.1 CDS EC55989_0803 NC_011748.1 851520 851954 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein T 851520..851954 Escherichia coli 55989 7144467 YP_002401901.1 CDS EC55989_0804 NC_011748.1 851947 854508 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein precursor H 851947..854508 Escherichia coli 55989 7144468 YP_002401902.1 CDS EC55989_0805 NC_011748.1 854505 854834 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein M 854505..854834 Escherichia coli 55989 7144469 YP_002401903.1 CDS EC55989_0806 NC_011748.1 854834 855532 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein L 854834..855532 Escherichia coli 55989 7144470 YP_002401904.1 CDS EC55989_0807 NC_011748.1 855538 856281 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber component K of prophage 855538..856281 Escherichia coli 55989 7144471 YP_002401905.1 CDS EC55989_0808 NC_011748.1 856179 856850 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail assembly protein I 856179..856850 Escherichia coli 55989 7144472 YP_002401906.1 CDS EC55989_0809 NC_011748.1 856911 860408 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J of prophage 856911..860408 Escherichia coli 55989 7144473 YP_002401907.1 CDS EC55989_0810 NC_011748.1 860479 861078 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; Lom-like outer membrane protein of phage origin 860479..861078 Escherichia coli 55989 7144474 YP_002401908.1 CDS EC55989_0811 NC_011748.1 861137 864217 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber protein 861137..864217 Escherichia coli 55989 7144475 YP_002401909.1 CDS tfaQ NC_011748.1 864217 864801 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; tail fiber chaperone; Qin prophage 864217..864801 Escherichia coli 55989 7144476 YP_002401910.1 CDS EC55989_0813 NC_011748.1 864875 866206 R Evidence 4 : Homologs of previously reported genes of unknown function; membrane protein complement(864875..866206) Escherichia coli 55989 7147777 YP_002401911.1 CDS EC55989_0814 NC_011748.1 866103 866297 D hypothetical protein 866103..866297 Escherichia coli 55989 7144477 YP_002401912.1 CDS EC55989_0815 NC_011748.1 866562 866735 D Evidence 6 : Doubtful CDS; hypothetical protein 866562..866735 Escherichia coli 55989 7144478 YP_002401913.1 CDS ybhB NC_011748.1 866952 867428 R YbhB; similar to rat and human kinase inhibitory proteins; kinase inhibitor protein complement(866952..867428) Escherichia coli 55989 7144479 YP_002401914.1 CDS bioA NC_011748.1 867487 868776 R catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate; adenosylmethionine-8-amino-7-oxononanoate aminotransferase complement(867487..868776) Escherichia coli 55989 7148185 YP_002401915.1 CDS bioB NC_011748.1 868863 869903 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11834738, 12475249, 14704425, 14967041, 20250955, 89066784, 94170810, 94190882, 97382445, 11686925; Product type e : enzyme; biotin synthase 868863..869903 Escherichia coli 55989 7145624 YP_002401916.1 CDS bioF NC_011748.1 869900 871054 D catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine; 8-amino-7-oxononanoate synthase 869900..871054 Escherichia coli 55989 7145625 YP_002401917.1 CDS bioC NC_011748.1 871041 871796 D methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth; biotin biosynthesis protein BioC 871041..871796 Escherichia coli 55989 7145628 YP_002401918.1 CDS bioD NC_011748.1 871789 872466 D DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase 871789..872466 Escherichia coli 55989 7145626 YP_002401919.1 CDS uvrB NC_011748.1 873045 875066 D The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion; excinuclease ABC subunit B 873045..875066 Escherichia coli 55989 7145627 YP_002401920.1 CDS ybhK NC_011748.1 875258 876166 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16272399; Product type pe : enzyme; transferase with NAD(P)-binding Rossmann-fold domain; UPF0052 family complement(875258..876166) Escherichia coli 55989 7147934 YP_002401921.1 CDS moaA NC_011748.1 876563 877552 D together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z; molybdenum cofactor biosynthesis protein A 876563..877552 Escherichia coli 55989 7148193 YP_002401922.1 CDS moaB NC_011748.1 877574 878086 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93368423; Product type pf : factor; molybdopterin biosynthesis protein B 877574..878086 Escherichia coli 55989 7146872 YP_002401923.1 CDS moaC NC_011748.1 878089 878574 D MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis; molybdenum cofactor biosynthesis protein MoaC 878089..878574 Escherichia coli 55989 7146873 YP_002401924.1 CDS moaD NC_011748.1 878567 878812 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin synthase small subunit 878567..878812 Escherichia coli 55989 7146874 YP_002401925.1 CDS moaE NC_011748.1 878814 879266 D catalyzes the conversion of molybdopterin precursor Z into molybdopterin; molybdopterin guanine dinucleotide biosynthesis protein MoaE 878814..879266 Escherichia coli 55989 7146875 YP_002401926.1 CDS ybhL NC_011748.1 879403 880107 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 879403..880107 Escherichia coli 55989 7146876 YP_002401927.1 CDS EC55989_0830 NC_011748.1 880252 880956 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; integral membrane protein 880252..880956 Escherichia coli 55989 7148194 YP_002401928.1 CDS ybhM NC_011748.1 881026 881739 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 881026..881739 Escherichia coli 55989 7144480 YP_002401929.1 CDS ybhN NC_011748.1 881775 882731 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(881775..882731) Escherichia coli 55989 7148195 YP_002401930.1 CDS ybhO NC_011748.1 882731 883972 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20102623, 10634942; Product type e : enzyme; cardiolipin synthase 2 complement(882731..883972) Escherichia coli 55989 7148196 YP_002401931.1 CDS ybhP NC_011748.1 883969 884730 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; metal-dependent hydrolase complement(883969..884730) Escherichia coli 55989 7148197 YP_002401932.1 CDS ybhQ NC_011748.1 884863 885273 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 884863..885273 Escherichia coli 55989 7148198 YP_002401933.1 CDS ybhR NC_011748.1 885235 886341 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: permease component of ABC superfamily complement(885235..886341) Escherichia coli 55989 7148199 YP_002401934.1 CDS ybhS NC_011748.1 886352 887485 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: permease component of ABC superfamily complement(886352..887485) Escherichia coli 55989 7148200 YP_002401935.1 CDS ybhF NC_011748.1 887478 889214 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter fused subunits of ABC superfamily: ATP-binding components complement(887478..889214) Escherichia coli 55989 7148201 YP_002401936.1 CDS ybhG NC_011748.1 889207 890205 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16092522; Product type pt : transporter; hypothetical protein complement(889207..890205) Escherichia coli 55989 7148188 YP_002401937.1 CDS ybiH NC_011748.1 890205 890876 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(890205..890876) Escherichia coli 55989 7148189 YP_002401938.1 CDS rhlE NC_011748.1 891105 892469 D this helicase is not essential cell growth; ATP-dependent RNA helicase RhlE 891105..892469 Escherichia coli 55989 7148206 YP_002401939.1 CDS ybiA NC_011748.1 892701 893183 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(892701..893183) Escherichia coli 55989 7147397 YP_002401940.1 CDS dinG NC_011748.1 893303 895453 D helicase involved in DNA repair and perhaps also replication; ATP-dependent DNA helicase DinG 893303..895453 Escherichia coli 55989 7148203 YP_002401941.1 CDS ybiB NC_011748.1 895481 896443 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; glycosyl transferase family protein 895481..896443 Escherichia coli 55989 7145917 YP_002401942.1 CDS ybiC NC_011748.1 896584 897669 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8405966; Product type pe : enzyme; hypothetical protein 896584..897669 Escherichia coli 55989 7148204 YP_002401943.1 CDS ybiJ NC_011748.1 897898 898158 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(897898..898158) Escherichia coli 55989 7148205 YP_002401944.1 CDS ybiI NC_011748.1 898423 898689 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(898423..898689) Escherichia coli 55989 7148208 YP_002401945.1 CDS ybiX NC_011748.1 898763 899440 R Evidence 4 : Homologs of previously reported genes of unknown function; hydroxylase complement(898763..899440) Escherichia coli 55989 7148207 YP_002401946.1 CDS fiu NC_011748.1 899482 901764 R Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein; catecholate siderophore receptor Fiu complement(899482..901764) Escherichia coli 55989 7148219 YP_002401947.1 CDS ybiM NC_011748.1 902029 902433 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(902029..902433) Escherichia coli 55989 7146114 YP_002401948.1 CDS ybiN NC_011748.1 902565 903491 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; SAM-dependent methyltransferase 902565..903491 Escherichia coli 55989 7148209 YP_002401949.1 CDS ybiO NC_011748.1 903488 905713 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; hypothetical protein complement(903488..905713) Escherichia coli 55989 7148210 YP_002401950.1 CDS glnQ NC_011748.1 905830 906552 R similar to ATP-binding component of ABC transporters; glutamine ABC transporter ATP-binding protein complement(905830..906552) Escherichia coli 55989 7148211 YP_002401951.1 CDS glnP NC_011748.1 906549 907208 R similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine; glutamine ABC transporter permease complement(906549..907208) Escherichia coli 55989 7146311 YP_002401952.1 CDS glnH NC_011748.1 907347 908093 R similar to periplasmic-binding component of ABC transporters; glutamine ABC transporter periplasmic protein complement(907347..908093) Escherichia coli 55989 7146310 YP_002401953.1 CDS dps NC_011748.1 908497 909000 R binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage; DNA starvation/stationary phase protection protein Dps complement(908497..909000) Escherichia coli 55989 7146307 YP_002401954.1 CDS rhtA NC_011748.1 909299 910186 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12648727, 8021175; Product type t : transporter; threonine and homoserine efflux system complement(909299..910186) Escherichia coli 55989 7145949 YP_002401955.1 CDS ompX NC_011748.1 910539 911054 D OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains; outer membrane protein X 910539..911054 Escherichia coli 55989 7147406 YP_002401956.1 CDS ybiP NC_011748.1 911103 912686 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16514146; Product type pe : enzyme; enzyme, UPF0141 family, inner membrane complement(911103..912686) Escherichia coli 55989 7147072 YP_002401957.1 CDS mntR NC_011748.1 913272 913739 D Transcriptional regulator that represses the manganese transporter MntH when manganese is present; manganese transport regulator MntR 913272..913739 Escherichia coli 55989 7147572 YP_002401958.1 CDS ybiR NC_011748.1 913736 914854 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 913736..914854 Escherichia coli 55989 7146871 YP_002401959.1 CDS ybiS NC_011748.1 914913 915833 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10493123, 9298646; hypothetical protein complement(914913..915833) Escherichia coli 55989 7148213 YP_002401960.1 CDS ybiT NC_011748.1 916052 917644 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11916677; Product type pt : transporter; transporter fused subunits of ABC superfamily: ATP-binding components 916052..917644 Escherichia coli 55989 7148214 YP_002401961.1 CDS EC55989_0865 NC_011748.1 917923 918903 D Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase, IS110 family 917923..918903 Escherichia coli 55989 7148215 YP_002401962.1 CDS ybiU NC_011748.1 919159 920424 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(919159..920424) Escherichia coli 55989 7144481 YP_002401963.1 CDS ybiV NC_011748.1 920576 921391 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15657928; Product type e : enzyme; type II HAD phosphatase complement(920576..921391) Escherichia coli 55989 7148216 YP_002401964.1 CDS ybiW NC_011748.1 921537 923969 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16218870; Product type pe : enzyme; glycyl radical cofactor protein complement(921537..923969) Escherichia coli 55989 7148217 YP_002401965.1 CDS ybiY NC_011748.1 923975 924901 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15581584; Product type pe : enzyme; AdoMet-dependent glycyl radical activating enzyme complement(923975..924901) Escherichia coli 55989 7148218 YP_002401966.1 CDS fsaA NC_011748.1 925005 925667 D similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase 925005..925667 Escherichia coli 55989 7148220 YP_002401967.1 CDS moeB NC_011748.1 925755 926504 R ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase; molybdopterin biosynthesis protein MoeB complement(925755..926504) Escherichia coli 55989 7146206 YP_002401968.1 CDS moeA NC_011748.1 926504 927739 R is involved in the formation of active molybdenum cofactor and the chelation of molybdenum; molybdopterin biosynthesis protein MoeA complement(926504..927739) Escherichia coli 55989 7146885 YP_002401969.1 CDS iaaA NC_011748.1 927943 928908 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15159592, 20508248, 3045084, 7984428; Product type e : enzyme; L-asparaginase 927943..928908 Escherichia coli 55989 7146884 YP_002401970.1 CDS yliA NC_011748.1 928928 930766 D with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains; glutathione transporter ATP-binding protein 928928..930766 Escherichia coli 55989 7146528 YP_002401971.1 CDS yliB NC_011748.1 930786 932324 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pt : transporter; peptide transporter subunit: periplasmic-binding component of ABC superfamily 930786..932324 Escherichia coli 55989 7149252 YP_002401972.1 CDS yliC NC_011748.1 932342 933262 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; peptide transporter permease subunit: membrane component of ABC superfamily 932342..933262 Escherichia coli 55989 7149253 YP_002401973.1 CDS yliD NC_011748.1 933265 934176 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; peptide transporter permease subunit: membrane component of ABC superfamily 933265..934176 Escherichia coli 55989 7149254 YP_002401974.1 CDS yliE NC_011748.1 934354 936702 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 934354..936702 Escherichia coli 55989 7149255 YP_002401975.1 CDS yliF NC_011748.1 936710 938038 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pe : enzyme; diguanylate cyclase 936710..938038 Escherichia coli 55989 7149256 YP_002401976.1 CDS rimO NC_011748.1 938085 939410 R catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit; ribosomal protein S12 methylthiotransferase complement(938085..939410) Escherichia coli 55989 7149257 YP_002401977.1 CDS bssR NC_011748.1 939623 940006 D BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssR 939623..940006 Escherichia coli 55989 7149258 YP_002401978.1 CDS yliI NC_011748.1 940117 941232 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16522795, 16864586; Product type e : enzyme; PQQ-dependent aldose sugar dehydrogenase precursor (asd) 940117..941232 Escherichia coli 55989 7145637 YP_002401979.1 CDS yliJ NC_011748.1 941229 941855 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; glutathione S-transferase complement(941229..941855) Escherichia coli 55989 7149259 YP_002401980.1 CDS dacC NC_011748.1 942102 943304 D penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 942102..943304 Escherichia coli 55989 7149260 YP_002401981.1 CDS deoR NC_011748.1 943351 944109 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89231635, 89336786, 92231401, 2994018; Product type r : regulator; DNA-binding transcriptional repressor DeoR complement(943351..944109) Escherichia coli 55989 7145843 YP_002401982.1 CDS ybjG NC_011748.1 944167 944763 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase complement(944167..944763) Escherichia coli 55989 7145890 YP_002401983.1 CDS cmr NC_011748.1 945048 946280 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10022825, 12578981, 14688269, 21217867, 21450803, 9079913, 9644262, 99030337, 8655497; Product type t : transporter; multidrug efflux system protein 945048..946280 Escherichia coli 55989 7148224 YP_002401984.1 CDS ybjH NC_011748.1 946321 946605 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(946321..946605) Escherichia coli 55989 7145729 YP_002401985.1 CDS ybjI NC_011748.1 946691 947506 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : enzyme; phosphatase complement(946691..947506) Escherichia coli 55989 7148225 YP_002401986.1 CDS ybjJ NC_011748.1 947506 948714 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter complement(947506..948714) Escherichia coli 55989 7148226 YP_002401987.1 CDS ybjK NC_011748.1 948798 949334 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 948798..949334 Escherichia coli 55989 7148227 YP_002401988.1 CDS ybjL NC_011748.1 949509 951194 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; hypothetical protein complement(949509..951194) Escherichia coli 55989 7147573 YP_002401989.1 CDS ybjM NC_011748.1 951464 951841 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 951464..951841 Escherichia coli 55989 7148229 YP_002401990.1 CDS grxA NC_011748.1 951871 952128 R functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase; glutaredoxin complement(951871..952128) Escherichia coli 55989 7148230 YP_002401991.1 CDS ybjC NC_011748.1 952288 952575 D YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function; hypothetical protein 952288..952575 Escherichia coli 55989 7146370 YP_002401992.1 CDS nfsA NC_011748.1 952559 953281 D NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds; nitroreductase A 952559..953281 Escherichia coli 55989 7148221 YP_002401993.1 CDS rimK NC_011748.1 953342 954244 D responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6; ribosomal protein S6 modification protein 953342..954244 Escherichia coli 55989 7146990 YP_002401994.1 CDS ybjN NC_011748.1 954332 954808 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 954332..954808 Escherichia coli 55989 7147420 YP_002401995.1 CDS potF NC_011748.1 955160 956272 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992, 9651355, 9298646, 8416922; Product type t : transporter; putrescine ABC transporter periplasmic-binding protein 955160..956272 Escherichia coli 55989 7148231 YP_002401996.1 CDS potG NC_011748.1 956367 957500 D part of the PotFGHI ATP-dependent putrescine transporter; putrescine ABC transporter ATP-binding protein 956367..957500 Escherichia coli 55989 7147214 YP_002401997.1 CDS potH NC_011748.1 957510 958466 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter; putrescine ABC transporter membrane protein 957510..958466 Escherichia coli 55989 7147215 YP_002401998.1 CDS potI NC_011748.1 958459 959304 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106992; Product type t : transporter; putrescine ABC transporter membrane protein 958459..959304 Escherichia coli 55989 7147216 YP_002401999.1 CDS ybjO NC_011748.1 959364 959852 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 959364..959852 Escherichia coli 55989 7147217 YP_002402000.1 CDS rumB NC_011748.1 959893 961020 D RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA; 23S rRNA methyluridine methyltransferase 959893..961020 Escherichia coli 55989 7148232 YP_002402001.1 CDS artJ NC_011748.1 961195 961926 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422; Product type t : transporter; arginine transporter subunit ; periplasmic-binding component of ABC superfamily complement(961195..961926) Escherichia coli 55989 7147558 YP_002402002.1 CDS artM NC_011748.1 962218 962886 R with ArtPQJI acts to transport arginine across the inner membrane; arginine transporter permease subunit ArtM complement(962218..962886) Escherichia coli 55989 7145556 YP_002402003.1 CDS artQ NC_011748.1 962886 963602 R with ArtPMJI transports arginine across the inner membrane; arginine transporter permease subunit ArtQ complement(962886..963602) Escherichia coli 55989 7145557 YP_002402004.1 CDS artI NC_011748.1 963609 964340 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93273744, 9298646, 9600841, 8801422, 9740056; Product type t : transporter; arginine transporter subunit ; periplasmic-binding component of ABC superfamily complement(963609..964340) Escherichia coli 55989 7145559 YP_002402005.1 CDS artP NC_011748.1 964358 965086 R With ArtMQJI transports arginine across the inner membrane; arginine transporter ATP-binding subunit complement(964358..965086) Escherichia coli 55989 7145555 YP_002402006.1 CDS ybjP NC_011748.1 965304 965819 R induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS; lipoprotein complement(965304..965819) Escherichia coli 55989 7145558 YP_002402007.1 CDS ybjQ NC_011748.1 965945 966268 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 965945..966268 Escherichia coli 55989 7148233 YP_002402008.1 CDS ybjR NC_011748.1 966265 967095 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; cell wall amidase and lipoprotein 966265..967095 Escherichia coli 55989 7148234 YP_002402009.1 CDS ybjS NC_011748.1 967092 968105 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; NAD(P)H-binding oxidoreductase with NAD(P)-binding Rossmann-fold domain complement(967092..968105) Escherichia coli 55989 7148235 YP_002402010.1 CDS ybjT NC_011748.1 968204 969634 R Evidence 4 : Homologs of previously reported genes of unknown function; NAD(P)-binding Rossmann-fold domain complement(968204..969634) Escherichia coli 55989 7148236 YP_002402011.1 CDS ltaE NC_011748.1 969645 970646 R low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine; L-threonine aldolase complement(969645..970646) Escherichia coli 55989 7148237 YP_002402012.1 CDS poxB NC_011748.1 970683 972401 R catalyzes the formation of acetate from pyruvate; pyruvate dehydrogenase complement(970683..972401) Escherichia coli 55989 7146753 YP_002402013.1 CDS hcr NC_011748.1 972534 973502 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20117674; Product type e : enzyme; HCP oxidoreductase complement(972534..973502) Escherichia coli 55989 7147219 YP_002402014.1 CDS hcp NC_011748.1 973514 975166 R catalyzes the reduction of hydroxylamine to ammonia and water; hydroxylamine reductase complement(973514..975166) Escherichia coli 55989 7146399 YP_002402015.1 CDS ybjE NC_011748.1 975310 976209 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter complement(975310..976209) Escherichia coli 55989 7146398 YP_002402016.1 CDS aqpZ NC_011748.1 976704 977399 R porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure; aquaporin Z complement(976704..977399) Escherichia coli 55989 7148223 YP_002402017.1 CDS ybjD NC_011748.1 977825 979483 D Evidence 4 : Homologs of previously reported genes of unknown function; nucleoside triphosphate hydrolase domain 977825..979483 Escherichia coli 55989 7145512 YP_002402018.1 CDS ybjX NC_011748.1 979480 980472 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(979480..980472) Escherichia coli 55989 7148222 YP_002402019.1 CDS macA NC_011748.1 980587 981702 D confers macrolide resistance via active drug efflux; macrolide transporter subunit MacA 980587..981702 Escherichia coli 55989 7148238 YP_002402020.1 CDS macB NC_011748.1 981699 983645 D with MacA is involved in the export of macrolide; macrolide transporter ATP-binding /permease 981699..983645 Escherichia coli 55989 7146764 YP_002402021.1 CDS cspD NC_011748.1 983718 983942 R inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible; stationary phase/starvation inducible regulatory protein CspD complement(983718..983942) Escherichia coli 55989 7146765 YP_002402022.1 CDS clpS NC_011748.1 984265 984585 D involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA; ATP-dependent Clp protease adaptor protein ClpS 984265..984585 Escherichia coli 55989 7145779 YP_002402023.1 CDS clpA NC_011748.1 984616 986892 D ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates; ATP-dependent Clp protease ATP-binding subunit 984616..986892 Escherichia coli 55989 7145725 YP_002402024.1 CDS infA NC_011748.1 987576 987794 R stimulates the activities of the other two initiation factors, IF-2 and IF-3; translation initiation factor IF-1 complement(987576..987794) Escherichia coli 55989 7145402 YP_002402025.1 CDS aat NC_011748.1 988079 988783 R leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys; leucyl/phenylalanyl-tRNA--protein transferase complement(988079..988783) Escherichia coli 55989 7146565 YP_002402026.1 CDS cydC NC_011748.1 988825 990546 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein complement(988825..990546) Escherichia coli 55989 7145421 YP_002402027.1 CDS cydD NC_011748.1 990547 992313 R in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c; cysteine/glutathione ABC transporter membrane/ATP-binding protein complement(990547..992313) Escherichia coli 55989 7145809 YP_002402028.1 CDS trxB NC_011748.1 992436 993401 R catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding; thioredoxin reductase complement(992436..993401) Escherichia coli 55989 7145810 YP_002402029.1 CDS lrp NC_011748.1 993946 994440 D mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system; leucine-responsive transcriptional regulator 993946..994440 Escherichia coli 55989 7147863 YP_002402030.1 CDS ftsK NC_011748.1 994575 998642 D DNA-binding membrane protein required for chromosome resolution and partitioning; DNA translocase FtsK 994575..998642 Escherichia coli 55989 7146744 YP_002402031.1 CDS lolA NC_011748.1 998794 999408 D participates with LolB in the incorporation of lipoprotein into the outer membrane; outer-membrane lipoprotein carrier protein 998794..999408 Escherichia coli 55989 7146215 YP_002402032.1 CDS ycaJ NC_011748.1 999419 1000762 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7567469, 7628437, 11459952, 11029431; Product type cp : cell process; recombination factor protein RarA 999419..1000762 Escherichia coli 55989 7146715 YP_002402033.1 CDS serS NC_011748.1 1000853 1002145 D catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; seryl-tRNA synthetase 1000853..1002145 Escherichia coli 55989 7148243 YP_002402034.1 CDS dmsA NC_011748.1 1002384 1004828 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 94171715, 10801884, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit A 1002384..1004828 Escherichia coli 55989 7147635 YP_002402035.1 CDS dmsB NC_011748.1 1004839 1005456 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91070067, 91355180, 92011349, 3062312; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit B 1004839..1005456 Escherichia coli 55989 7145928 YP_002402036.1 CDS dmsC NC_011748.1 1005458 1006321 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91008971, 92011349, 3062312, 8429002; Product type e : enzyme; dimethyl sulfoxide reductase, anaerobic subunit C 1005458..1006321 Escherichia coli 55989 7145929 YP_002402037.1 CDS ycaC NC_011748.1 1006357 1006983 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9782055, 3062312, 11714269; Product type pe : enzyme; hydrolase complement(1006357..1006983) Escherichia coli 55989 7145930 YP_002402038.1 CDS ycaD NC_011748.1 1007297 1008445 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; MFS family transporter protein 1007297..1008445 Escherichia coli 55989 7148240 YP_002402039.1 CDS ycaM NC_011748.1 1008655 1010085 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type pt : transporter; transporter 1008655..1010085 Escherichia coli 55989 7148241 YP_002402040.1 CDS ycaN NC_011748.1 1010086 1010994 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(1010086..1010994) Escherichia coli 55989 7148246 YP_002402041.1 CDS ycaK NC_011748.1 1011094 1011684 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3053170; Product type pe : enzyme; hypothetical protein 1011094..1011684 Escherichia coli 55989 7148247 YP_002402042.1 CDS pflA NC_011748.1 1011766 1012506 R activates pyruvate formate-lyase 1 under anaerobic conditions; pyruvate formate lyase-activating enzyme 1 complement(1011766..1012506) Escherichia coli 55989 7148244 YP_002402043.1 CDS pflB NC_011748.1 1012698 1014980 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91064082, 92276323, 10504733, 1310545, 2651404, 3053170, 9629924; Product type e : enzyme; pyruvate formate lyase I complement(1012698..1014980) Escherichia coli 55989 7147141 YP_002402044.1 CDS focA NC_011748.1 1015035 1015892 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293770, 2651404; Product type t : transporter; formate transporter complement(1015035..1015892) Escherichia coli 55989 7147142 YP_002402045.1 CDS ycaO NC_011748.1 1016297 1018057 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1016297..1018057) Escherichia coli 55989 7146166 YP_002402046.1 CDS ycaP NC_011748.1 1018187 1018879 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1018187..1018879 Escherichia coli 55989 7148248 YP_002402047.1 CDS serC NC_011748.1 1019078 1020166 D catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine; phosphoserine aminotransferase 1019078..1020166 Escherichia coli 55989 7148249 YP_002402048.1 CDS aroA NC_011748.1 1020237 1021520 D catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis; 3-phosphoshikimate 1-carboxyvinyltransferase 1020237..1021520 Escherichia coli 55989 7147634 YP_002402049.1 CDS ycaL NC_011748.1 1021689 1022453 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; lipoprotein with metallohydrolase domain 1021689..1022453 Escherichia coli 55989 7145539 YP_002402050.1 CDS cmk NC_011748.1 1022626 1023309 D Catalyzes the formation of (d)CDP from ATP and (d)CMP; cytidylate kinase 1022626..1023309 Escherichia coli 55989 7148245 YP_002402051.1 CDS rpsA NC_011748.1 1023420 1025093 D in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins; 30S ribosomal protein S1 1023420..1025093 Escherichia coli 55989 7145728 YP_002402052.1 CDS ihfB NC_011748.1 1025253 1025537 D This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit beta 1025253..1025537 Escherichia coli 55989 7147505 YP_002402053.1 CDS ycaI NC_011748.1 1025744 1028008 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 1025744..1028008 Escherichia coli 55989 7146547 YP_002402054.1 CDS msbA NC_011748.1 1028045 1029793 D involved in the transport of lipid A across the inner membrane; lipid transporter ATP-binding/permease 1028045..1029793 Escherichia coli 55989 7148242 YP_002402055.1 CDS lpxK NC_011748.1 1029790 1030776 D transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate; tetraacyldisaccharide 4'-kinase 1029790..1030776 Escherichia coli 55989 7146906 YP_002402056.1 CDS ycaQ NC_011748.1 1030813 1032045 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1030813..1032045 Escherichia coli 55989 7146740 YP_002402057.1 CDS ycaR NC_011748.1 1032097 1032279 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1032097..1032279 Escherichia coli 55989 7148250 YP_002402058.1 CDS kdsB NC_011748.1 1032276 1033022 D CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS; 3-deoxy-manno-octulosonate cytidylyltransferase 1032276..1033022 Escherichia coli 55989 7148251 YP_002402059.1 CDS ycbJ NC_011748.1 1033176 1034069 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1033176..1034069 Escherichia coli 55989 7146660 YP_002402060.1 CDS ycbC NC_011748.1 1034046 1034825 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(1034046..1034825) Escherichia coli 55989 7148256 YP_002402061.1 CDS EC55989_0966 NC_011748.1 1034728 1034892 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1034728..1034892) Escherichia coli 55989 7148253 YP_002402062.1 CDS smtA NC_011748.1 1034961 1035746 D involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA; metallothionein SmtA 1034961..1035746 Escherichia coli 55989 7144482 YP_002402063.1 CDS mukF NC_011748.1 1035743 1037065 D acts with MukB and MukE to condense the chromosome and allow for segregation during cell division; condesin subunit F 1035743..1037065 Escherichia coli 55989 7147670 YP_002402064.1 CDS mukE NC_011748.1 1037073 1037750 D acts with MukB and MukF to condense the chromosome and allow for segregation during cell division; condesin subunit E 1037073..1037750 Escherichia coli 55989 7146920 YP_002402065.1 CDS mukB NC_011748.1 1037750 1042210 D SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects; cell division protein MukB 1037750..1042210 Escherichia coli 55989 7146919 YP_002402066.1 CDS ycbB NC_011748.1 1042471 1044318 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 1042471..1044318 Escherichia coli 55989 7146918 YP_002402067.1 CDS ycbK NC_011748.1 1044499 1045047 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1044499..1045047 Escherichia coli 55989 7148252 YP_002402068.1 CDS ycbL NC_011748.1 1045074 1045721 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14529289; Product type pe : enzyme; metal-binding hydrolase 1045074..1045721 Escherichia coli 55989 7148257 YP_002402069.1 CDS EC55989_0975 NC_011748.1 1045963 1046943 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family complement(1045963..1046943) Escherichia coli 55989 7148258 YP_002402070.1 CDS aspC NC_011748.1 1047222 1048412 R catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase complement(1047222..1048412) Escherichia coli 55989 7144483 YP_002402071.1 CDS ompF NC_011748.1 1048597 1049685 R outer membrane porin F; 1a; Ia; b; outer membrane protein F complement(1048597..1049685) Escherichia coli 55989 7145572 YP_002402072.1 CDS asnC NC_011748.1 1050287 1051687 R catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; asparaginyl-tRNA synthetase complement(1050287..1051687) Escherichia coli 55989 7147067 YP_002402073.1 CDS pncB NC_011748.1 1051856 1053058 R catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate; nicotinate phosphoribosyltransferase complement(1051856..1053058) Escherichia coli 55989 7145570 YP_002402074.1 CDS pepN NC_011748.1 1053324 1055936 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101837, 86164315, 87163509, 2436977, 3018440; Product type e : enzyme; aminopeptidase 1053324..1055936 Escherichia coli 55989 7147202 YP_002402075.1 CDS ssuB NC_011748.1 1056143 1056910 R part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease; aliphatic sulfonates transport ATP-binding subunit complement(1056143..1056910) Escherichia coli 55989 7147134 YP_002402076.1 CDS ssuC NC_011748.1 1056907 1057698 R part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter permease complement(1056907..1057698) Escherichia coli 55989 7147720 YP_002402077.1 CDS ssuD NC_011748.1 1057709 1058854 R catalyzes the release of sulfite from alkanesulfonates; alkanesulfonate monooxygenase complement(1057709..1058854) Escherichia coli 55989 7147721 YP_002402078.1 CDS ssuA NC_011748.1 1058851 1059810 R part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease; alkanesulfonate transporter substrate-binding subunit complement(1058851..1059810) Escherichia coli 55989 7147722 YP_002402079.1 CDS ssuE NC_011748.1 1059803 1060378 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20245523, 99410391, 99436146, 8774726; Product type e : enzyme; NAD(P)H-dependent FMN reductase complement(1059803..1060378) Escherichia coli 55989 7147719 YP_002402080.1 CDS ycbQ NC_011748.1 1060725 1061276 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15380559; Product type ps : structure; fimbrial-like adhesin protein 1060725..1061276 Escherichia coli 55989 7147723 YP_002402081.1 CDS ycbR NC_011748.1 1061359 1062060 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; periplasmic pilin chaperone 1061359..1062060 Escherichia coli 55989 7148259 YP_002402082.1 CDS ycbS NC_011748.1 1062085 1064685 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; outer membrane export usher protein 1062085..1064685 Escherichia coli 55989 7148260 YP_002402083.1 CDS ycbT NC_011748.1 1064676 1065746 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7721701; Product type ps : structure; fimbrial-like adhesin protein 1064676..1065746 Escherichia coli 55989 7148261 YP_002402084.1 CDS ycbU NC_011748.1 1065758 1066300 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 1065758..1066300 Escherichia coli 55989 7148262 YP_002402085.1 CDS ycbV NC_011748.1 1066308 1066823 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 1066308..1066823 Escherichia coli 55989 7148263 YP_002402086.1 CDS ycbF NC_011748.1 1066816 1067526 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; pili assembly chaperone 1066816..1067526 Escherichia coli 55989 7148264 YP_002402087.1 CDS pyrD NC_011748.1 1067637 1068647 D catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors; dihydroorotate dehydrogenase 2 1067637..1068647 Escherichia coli 55989 7148254 YP_002402088.1 CDS ycbW NC_011748.1 1068821 1069363 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1068821..1069363 Escherichia coli 55989 7147319 YP_002402089.1 CDS ycbX NC_011748.1 1069360 1070469 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1327782; Product type pe : enzyme; 2Fe-2S cluster-containing protein complement(1069360..1070469) Escherichia coli 55989 7148265 YP_002402090.1 CDS rlmL NC_011748.1 1070713 1072821 D catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA; 23S rRNA m(2)G2445 methyltransferase 1070713..1072821 Escherichia coli 55989 7148266 YP_002402091.1 CDS uup NC_011748.1 1072832 1074739 D Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth; ABC transporter ATPase 1072832..1074739 Escherichia coli 55989 7148267 YP_002402092.1 CDS pqiA NC_011748.1 1074869 1076122 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible membrane protein A 1074869..1076122 Escherichia coli 55989 7147932 YP_002402093.1 CDS pqiB NC_011748.1 1076127 1077767 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95270582; Product type cp : cell process; paraquat-inducible protein B 1076127..1077767 Escherichia coli 55989 7147236 YP_002402094.1 CDS ymbA NC_011748.1 1077779 1078327 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1077779..1078327 Escherichia coli 55989 7147237 YP_002402095.1 CDS rmf NC_011748.1 1078583 1078750 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1101029, 90207255, 2832401, 8440252; Product type f : factor; ribosome modulation factor 1078583..1078750 Escherichia coli 55989 7149263 YP_002402096.1 CDS fabA NC_011748.1 1078820 1079338 R catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP; 3-hydroxydecanoyl-ACP dehydratase complement(1078820..1079338) Escherichia coli 55989 7147430 YP_002402097.1 CDS ycbZ NC_011748.1 1079407 1081167 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; ATP-dependent protease complement(1079407..1081167) Escherichia coli 55989 7146046 YP_002402098.1 CDS ycbG NC_011748.1 1081353 1081805 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1081353..1081805 Escherichia coli 55989 7148268 YP_002402099.1 CDS ompA NC_011748.1 1081881 1082921 R OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d; outer membrane protein A complement(1081881..1082921) Escherichia coli 55989 7148255 YP_002402100.1 CDS sulA NC_011748.1 1083278 1083787 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10368140, 91072263, 93163041, 98348458, 3297925, 6253901, 6306396; Product type cp : cell process; SOS cell division inhibitor complement(1083278..1083787) Escherichia coli 55989 7146624 YP_002402101.1 CDS yccR NC_011748.1 1084006 1084635 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1084006..1084635 Escherichia coli 55989 7147739 YP_002402102.1 CDS yccS NC_011748.1 1084598 1086751 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(1084598..1086751) Escherichia coli 55989 7148275 YP_002402103.1 CDS yccF NC_011748.1 1086770 1087216 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(1086770..1087216) Escherichia coli 55989 7148276 YP_002402104.1 CDS helD NC_011748.1 1087339 1089393 D catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand; DNA helicase IV 1087339..1089393 Escherichia coli 55989 7148272 YP_002402105.1 CDS mgsA NC_011748.1 1089425 1089883 R catalyzes the formation of methylglyoxal from glycerone phosphate; methylglyoxal synthase complement(1089425..1089883) Escherichia coli 55989 7146406 YP_002402106.1 CDS yccT NC_011748.1 1089979 1090641 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1089979..1090641) Escherichia coli 55989 7146842 YP_002402107.1 CDS yccU NC_011748.1 1090814 1091227 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; CoA-binding protein 1090814..1091227 Escherichia coli 55989 7148277 YP_002402108.1 CDS yccV NC_011748.1 1091272 1091589 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700277, 15569148; Product type f : factor; heat shock protein HspQ complement(1091272..1091589) Escherichia coli 55989 7148278 YP_002402109.1 CDS yccW NC_011748.1 1091647 1092750 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; AdoMet-dependent methyltransferase, UPF0064 family complement(1091647..1092750) Escherichia coli 55989 7148279 YP_002402110.1 CDS yccX NC_011748.1 1092719 1093210 D catalyzes the hydrolysis of acylphosphate; acylphosphatase 1092719..1093210 Escherichia coli 55989 7148280 YP_002402111.1 CDS tusE NC_011748.1 1093207 1093536 R transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein TusE complement(1093207..1093536) Escherichia coli 55989 7148281 YP_002402112.1 CDS yccA NC_011748.1 1093627 1094286 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6376117; Product type m : membrane component; hypothetical protein complement(1093627..1094286) Escherichia coli 55989 7147879 YP_002402113.1 CDS EC55989_1020 NC_011748.1 1094492 1094704 D Evidence 6 : Doubtful CDS; hypothetical protein 1094492..1094704 Escherichia coli 55989 7148269 YP_002402114.1 CDS EC55989_1021 NC_011748.1 1094694 1095713 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; integrase from prophage complement(1094694..1095713) Escherichia coli 55989 7144484 YP_002402115.1 CDS EC55989_1022 NC_011748.1 1095691 1096071 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(1095691..1096071) Escherichia coli 55989 7144485 YP_002402116.1 CDS EC55989_1023 NC_011748.1 1096001 1098493 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; exonuclease from phage origin complement(1096001..1098493) Escherichia coli 55989 7144486 YP_002402117.1 CDS EC55989_1024 NC_011748.1 1098589 1098777 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1098589..1098777) Escherichia coli 55989 7144487 YP_002402118.1 CDS EC55989_1025 NC_011748.1 1098774 1099067 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; regulator of cell division encoded by prophage complement(1098774..1099067) Escherichia coli 55989 7144488 YP_002402119.1 CDS ydfC NC_011748.1 1099530 1099748 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage complement(1099530..1099748) Escherichia coli 55989 7145911 YP_002402120.1 CDS ydfB NC_011748.1 1099778 1099906 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage complement(1099778..1099906) Escherichia coli 55989 7148431 YP_002402121.1 CDS ydfA NC_011748.1 1099908 1100063 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage complement(1099908..1100063) Escherichia coli 55989 7148430 YP_002402122.1 CDS dicA NC_011748.1 1100271 1100678 R The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown.; transcriptional repressor DicA complement(1100271..1100678) Escherichia coli 55989 7148428 YP_002402123.1 CDS dicC NC_011748.1 1100755 1100982 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88232418, 3532030; Product type h : extrachromosomal origin; DNA-binding transcriptional regulator DicC 1100755..1100982 Escherichia coli 55989 7145906 YP_002402124.1 CDS EC55989_1031 NC_011748.1 1100966 1101517 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1100966..1101517 Escherichia coli 55989 7145909 YP_002402125.1 CDS EC55989_1032 NC_011748.1 1101414 1102529 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1101414..1102529 Escherichia coli 55989 7144490 YP_002402126.1 CDS EC55989_1033 NC_011748.1 1102318 1102983 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; replication protein in prophage 1102318..1102983 Escherichia coli 55989 7144491 YP_002402127.1 CDS EC55989_1034 NC_011748.1 1102999 1103787 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1102999..1103787 Escherichia coli 55989 7144492 YP_002402128.1 CDS EC55989_1035 NC_011748.1 1103788 1104225 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1103788..1104225 Escherichia coli 55989 7144493 YP_002402129.1 CDS EC55989_1036 NC_011748.1 1104222 1104710 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; methyltransferase 1104222..1104710 Escherichia coli 55989 7144494 YP_002402130.1 CDS EC55989_1037 NC_011748.1 1104703 1104957 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 1104703..1104957 Escherichia coli 55989 7144495 YP_002402131.1 CDS EC55989_1038 NC_011748.1 1104950 1105261 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1104950..1105261 Escherichia coli 55989 7144496 YP_002402132.1 CDS EC55989_1039 NC_011748.1 1105390 1105572 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1105390..1105572 Escherichia coli 55989 7144497 YP_002402133.1 CDS EC55989_1040 NC_011748.1 1105565 1105741 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1105565..1105741 Escherichia coli 55989 7144498 YP_002402134.1 CDS EC55989_1041 NC_011748.1 1105738 1106253 D Evidence 4 : Homologs of previously reported genes of unknown function; prophage protein 1105738..1106253 Escherichia coli 55989 7144499 YP_002402135.1 CDS insB NC_011748.1 1106485 1106988 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(1106485..1106988) Escherichia coli 55989 7144500 YP_002402136.1 CDS insA NC_011748.1 1106907 1107182 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(1106907..1107182) Escherichia coli 55989 7146583 YP_002402137.1 CDS rem NC_011748.1 1107961 1108212 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2990907; Product type h : extrachromosomal origin; Qin prophage 1107961..1108212 Escherichia coli 55989 7146571 YP_002402138.1 CDS ydfU NC_011748.1 1108559 1109614 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1108559..1109614 Escherichia coli 55989 7147370 YP_002402139.1 CDS EC55989_1046 NC_011748.1 1109615 1109995 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; Holliday juction resolvase 1109615..1109995 Escherichia coli 55989 7148442 YP_002402140.1 CDS EC55989_1047 NC_011748.1 1109992 1110813 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; antitermination protein Q of prophage 1109992..1110813 Escherichia coli 55989 7144501 YP_002402141.1 CDS EC55989_1048 NC_011748.1 1110953 1111237 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1110953..1111237 Escherichia coli 55989 7144502 YP_002402142.1 CDS EC55989_1049 NC_011748.1 1111388 1112437 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; DNA adenine methyltransferase ( DNA methylase) from phage origin 1111388..1112437 Escherichia coli 55989 7144503 YP_002402143.1 CDS EC55989_1050 NC_011748.1 1113226 1115088 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1113226..1115088 Escherichia coli 55989 7145325 YP_002402144.1 CDS EC55989_1051 NC_011748.1 1115133 1115453 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Lysis protein S homolog from lambdoid prophage 1115133..1115453 Escherichia coli 55989 7144505 YP_002402145.1 CDS EC55989_1052 NC_011748.1 1115458 1116264 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1115458..1116264 Escherichia coli 55989 7144506 YP_002402146.1 CDS EC55989_1053 NC_011748.1 1116274 1116588 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1116274..1116588) Escherichia coli 55989 7144507 YP_002402147.1 CDS ydfQ NC_011748.1 1116717 1117250 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane-associated lysozyme; Qin prophage 1116717..1117250 Escherichia coli 55989 7144508 YP_002402148.1 CDS EC55989_1055 NC_011748.1 1117328 1117540 D Evidence 4 : Homologs of previously reported genes of unknown function; prophage protein 1117328..1117540 Escherichia coli 55989 7148439 YP_002402149.1 CDS EC55989_1056 NC_011748.1 1117521 1117793 D Evidence 6 : Doubtful CDS; hypothetical protein 1117521..1117793 Escherichia coli 55989 7144509 YP_002402150.1 CDS rz NC_011748.1 1117809 1118360 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein) from bacteriophage origin 1117809..1118360 Escherichia coli 55989 7144510 YP_002402151.1 CDS EC55989_1059 NC_011748.1 1118813 1119289 D Evidence 4 : Homologs of previously reported genes of unknown function; phage protein 1118813..1119289 Escherichia coli 55989 7147596 YP_002402152.1 CDS EC55989_1060 NC_011748.1 1119286 1121409 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage terminase large subunit 1119286..1121409 Escherichia coli 55989 7144511 YP_002402153.1 CDS EC55989_1061 NC_011748.1 1121382 1121618 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1121382..1121618 Escherichia coli 55989 7144512 YP_002402154.1 CDS EC55989_1062 NC_011748.1 1121618 1123120 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; head-tail preconnector protein 1121618..1123120 Escherichia coli 55989 7144513 YP_002402155.1 CDS clp NC_011748.1 1122918 1125089 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; ATP-dependent Clp protease proteolytic subunit (Endopeptidase Clp) of prophage 1122918..1125089 Escherichia coli 55989 7144514 YP_002402156.1 CDS EC55989_1064 NC_011748.1 1125177 1125503 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical membrane protein from phage origin 1125177..1125503 Escherichia coli 55989 7145721 YP_002402157.1 CDS EC55989_1065 NC_011748.1 1125496 1125777 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1125496..1125777 Escherichia coli 55989 7144515 YP_002402158.1 CDS Z NC_011748.1 1125774 1126403 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein Z 1125774..1126403 Escherichia coli 55989 7144516 YP_002402159.1 CDS U NC_011748.1 1126416 1126814 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein U 1126416..1126814 Escherichia coli 55989 7149486 YP_002402160.1 CDS EC55989_1068 NC_011748.1 1126822 1127568 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail protein V 1126822..1127568 Escherichia coli 55989 7147886 YP_002402161.1 CDS EC55989_1069 NC_011748.1 1127587 1128018 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein G 1127587..1128018 Escherichia coli 55989 7144517 YP_002402162.1 CDS T NC_011748.1 1128045 1128449 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein T 1128045..1128449 Escherichia coli 55989 7144518 YP_002402163.1 CDS EC55989_1071 NC_011748.1 1128430 1131042 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein precursor H 1128430..1131042 Escherichia coli 55989 7147743 YP_002402164.1 CDS EC55989_1072 NC_011748.1 1131039 1131371 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein M 1131039..1131371 Escherichia coli 55989 7144519 YP_002402165.1 CDS EC55989_1073 NC_011748.1 1131371 1132069 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein L 1131371..1132069 Escherichia coli 55989 7144520 YP_002402166.1 CDS EC55989_1074 NC_011748.1 1132032 1132817 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber component K of prophage 1132032..1132817 Escherichia coli 55989 7144521 YP_002402167.1 CDS EC55989_1075 NC_011748.1 1132715 1133386 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail assembly protein I 1132715..1133386 Escherichia coli 55989 7144522 YP_002402168.1 CDS EC55989_1076 NC_011748.1 1133447 1136842 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J 1133447..1136842 Escherichia coli 55989 7144523 YP_002402169.1 CDS EC55989_1077 NC_011748.1 1136910 1137509 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; Lom-like outer membrane protein of prophage 1136910..1137509 Escherichia coli 55989 7144524 YP_002402170.1 CDS EC55989_1078 NC_011748.1 1137661 1139064 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber protein (modular protein) 1137661..1139064 Escherichia coli 55989 7144525 YP_002402171.1 CDS EC55989_1079 NC_011748.1 1138986 1139681 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1138986..1139681 Escherichia coli 55989 7144526 YP_002402172.1 CDS hyaA NC_011748.1 1140806 1141924 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86192450, 90202716, 92215587; Product type e : enzyme; hydrogenase 1, small subunit 1140806..1141924 Escherichia coli 55989 7145401 YP_002402173.1 CDS hyaB NC_011748.1 1141921 1143714 D involved in hydrogen cycling during fermentative growth; hydrogenase 1 large subunit 1141921..1143714 Escherichia coli 55989 7146482 YP_002402174.1 CDS hyaC NC_011748.1 1143733 1144440 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type c : carrier; hydrogenase 1 b-type cytochrome subunit 1143733..1144440 Escherichia coli 55989 7146483 YP_002402175.1 CDS hyaD NC_011748.1 1144437 1145024 D HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1); hydrogenase 1 maturation protease 1144437..1145024 Escherichia coli 55989 7146484 YP_002402176.1 CDS hyaE NC_011748.1 1145021 1145419 D involved in processing hydrogenase proteins HyaA and HyaB; hydrogenase-1 operon protein HyaE 1145021..1145419 Escherichia coli 55989 7146485 YP_002402177.1 CDS hyaF NC_011748.1 1145416 1146273 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202716, 91310595, 92215587; Product type f : factor; protein involved in nickel incorporation into hydrogenase-1 proteins 1145416..1146273 Escherichia coli 55989 7146486 YP_002402178.1 CDS appC NC_011748.1 1146407 1147951 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit I 1146407..1147951 Escherichia coli 55989 7146487 YP_002402179.1 CDS appB NC_011748.1 1147963 1149099 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92049231, 96198179; Product type c : carrier; cytochrome bd-II oxidase subunit II 1147963..1149099 Escherichia coli 55989 7145510 YP_002402180.1 CDS appA NC_011748.1 1149284 1150582 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20122624, 92049231, 93054596, 10696472, 2168385, 3038201, 8387749; Product type e : enzyme; phosphoanhydride phosphorylase 1149284..1150582 Escherichia coli 55989 7145509 YP_002402181.1 CDS yccC NC_011748.1 1150697 1152877 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10369665, 11090276, 2168385, 7984428; Product type e : enzyme; cryptic autophosphorylating protein tyrosine kinase Etk complement(1150697..1152877) Escherichia coli 55989 7145508 YP_002402182.1 CDS etp NC_011748.1 1152897 1153343 R Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk; phosphotyrosine-protein phosphatase complement(1152897..1153343) Escherichia coli 55989 7148270 YP_002402183.1 CDS yccZ NC_011748.1 1153331 1154470 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8759852; Product type pt : transporter; exopolysaccharide export protein complement(1153331..1154470) Escherichia coli 55989 7146025 YP_002402184.1 CDS ymcA NC_011748.1 1154516 1156612 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1154516..1156612) Escherichia coli 55989 7148282 YP_002402185.1 CDS ymcB NC_011748.1 1156612 1157358 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1156612..1157358) Escherichia coli 55989 7149264 YP_002402186.1 CDS ymcC NC_011748.1 1157355 1157999 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; outer membrane lipoprotein complement(1157355..1157999) Escherichia coli 55989 7149265 YP_002402187.1 CDS EC55989_1095 NC_011748.1 1158081 1158353 R hypothetical protein complement(1158081..1158353) Escherichia coli 55989 7149266 YP_002402188.1 CDS ymcD NC_011748.1 1158106 1158411 R Evidence 4 : Homologs of previously reported genes of unknown function; inner membrane protein complement(1158106..1158411) Escherichia coli 55989 7144528 YP_002402189.1 CDS cspH NC_011748.1 1158853 1159065 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9484881, 9439003; Product type f : factor; stress protein, member of the CspA-family complement(1158853..1159065) Escherichia coli 55989 7149267 YP_002402190.1 CDS insB NC_011748.1 1159124 1159627 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(1159124..1159627) Escherichia coli 55989 7145782 YP_002402191.1 CDS insA NC_011748.1 1159546 1159821 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(1159546..1159821) Escherichia coli 55989 7146584 YP_002402192.1 CDS cspG NC_011748.1 1160128 1160340 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9484881, 15466053, 8631696, 9439003; Product type r : regulator; cold shock protein CspG 1160128..1160340 Escherichia coli 55989 7146572 YP_002402193.1 CDS gnsA NC_011748.1 1160734 1160907 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15317805, 11544213; Product type pr : regulator; regulator of phosphatidylethanolamine synthesis 1160734..1160907 Escherichia coli 55989 7145781 YP_002402194.1 CDS yccM NC_011748.1 1160956 1162029 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; 4Fe-4S binding protein complement(1160956..1162029) Escherichia coli 55989 7146348 YP_002402195.1 CDS torS NC_011748.1 1162101 1164845 R Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide; hybrid sensory histidine kinase TorS complement(1162101..1164845) Escherichia coli 55989 7148274 YP_002402196.1 CDS torT NC_011748.1 1164928 1165956 D periplasmic sensory protein associated with the TorRS two-component regulatory system; TMAO reductase system periplasmic protein TorT 1164928..1165956 Escherichia coli 55989 7147825 YP_002402197.1 CDS torR NC_011748.1 1165929 1166621 R response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes; DNA-binding transcriptional regulator TorR complement(1165929..1166621) Escherichia coli 55989 7147826 YP_002402198.1 CDS torC NC_011748.1 1166751 1167923 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293785, 94314186, 99340208, 11056172, 11562502; Product type c : carrier; trimethylamine N-oxide (TMAO) reductase I, cytochrome c-type subunit 1166751..1167923 Escherichia coli 55989 7147824 YP_002402199.1 CDS torA NC_011748.1 1167923 1170469 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193091, 90089471, 94293785, 8302830, 8022286; Product type e : enzyme; trimethylamine N-oxide (TMAO) reductase I, catalytic subunit 1167923..1170469 Escherichia coli 55989 7147821 YP_002402200.1 CDS torD NC_011748.1 1170466 1171065 D TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor; chaperone protein TorD 1170466..1171065 Escherichia coli 55989 7147820 YP_002402201.1 CDS cbpM NC_011748.1 1171158 1171463 R with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA; chaperone-modulator protein CbpM complement(1171158..1171463) Escherichia coli 55989 7147822 YP_002402202.1 CDS cbpA NC_011748.1 1171463 1172383 R functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock; curved DNA-binding protein CbpA complement(1171463..1172383) Escherichia coli 55989 7145668 YP_002402203.1 CDS yccE NC_011748.1 1172716 1173903 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8302830; hypothetical protein 1172716..1173903 Escherichia coli 55989 7145667 YP_002402204.1 CDS agp NC_011748.1 1174192 1175433 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12455612, 90368616, 91297199, 2153660, 9298646; Product type e : enzyme; glucose-1-phosphatase/inositol phosphatase 1174192..1175433 Escherichia coli 55989 7148271 YP_002402205.1 CDS yccJ NC_011748.1 1175471 1175698 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1175471..1175698) Escherichia coli 55989 7145473 YP_002402206.1 CDS wrbA NC_011748.1 1175719 1176315 R stationary phase protein that binds TrpR repressor; TrpR binding protein WrbA complement(1175719..1176315) Escherichia coli 55989 7148273 YP_002402207.1 CDS EC55989_1115 NC_011748.1 1176525 1176755 D Evidence 6 : Doubtful CDS; hypothetical protein 1176525..1176755 Escherichia coli 55989 7147973 YP_002402208.1 CDS ymdF NC_011748.1 1176688 1176861 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1176688..1176861 Escherichia coli 55989 7144529 YP_002402209.1 CDS rutG NC_011748.1 1176944 1178272 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type t : transporter; pyrimidine transporter complement(1176944..1178272) Escherichia coli 55989 7149271 YP_002402210.1 CDS rutF NC_011748.1 1178293 1178787 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542, 10633095; Product type e : enzyme; flavin:NADH oxidoreductase subunit of alternative pyrimidine degradation pathway complement(1178293..1178787) Escherichia coli 55989 7147567 YP_002402211.1 CDS rutE NC_011748.1 1178798 1179388 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; hypothetical protein complement(1178798..1179388) Escherichia coli 55989 7147566 YP_002402212.1 CDS rutD NC_011748.1 1179398 1180198 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway complement(1179398..1180198) Escherichia coli 55989 7147565 YP_002402213.1 CDS rutC NC_011748.1 1180206 1180592 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway complement(1180206..1180592) Escherichia coli 55989 7147564 YP_002402214.1 CDS rutB NC_011748.1 1180604 1181296 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; enzyme of the alternative pyrimidine degradation pathway complement(1180604..1181296) Escherichia coli 55989 7147563 YP_002402215.1 CDS rutA NC_011748.1 1181296 1182444 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type e : enzyme; monooxygenase of the alternative pyrimidine degradation pathway complement(1181296..1182444) Escherichia coli 55989 7147562 YP_002402216.1 CDS rutR NC_011748.1 1182675 1183313 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16540542; Product type r : regulator; DNA-binding transcriptional regulator of the alternative pyrimidine degradation pathway 1182675..1183313 Escherichia coli 55989 7147561 YP_002402217.1 CDS putA NC_011748.1 1183353 1187315 R proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein; trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase complement(1183353..1187315) Escherichia coli 55989 7147568 YP_002402218.1 CDS putP NC_011748.1 1187738 1189246 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12923181, 88213396, 91227628, 93132799, 98359785, 1400239, 1567896, 3053649, 3053687, 3302614, 3325781, 8119910; Product type t : transporter; proline:sodium symporter 1187738..1189246 Escherichia coli 55989 7147306 YP_002402219.1 CDS efeU NC_011748.1 1189779 1190618 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type t : transporter; ferrous iron permease 1189779..1190618 Escherichia coli 55989 7147307 YP_002402220.1 CDS efeO NC_011748.1 1190676 1191803 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 10493123; Product type t : transporter; hypothetical protein 1190676..1191803 Escherichia coli 55989 7145980 YP_002402221.1 CDS efeB NC_011748.1 1191809 1193080 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17627767, 16551627, 15375152; Product type t : transporter; iron transport heme-binding periplasmic protein 1191809..1193080 Escherichia coli 55989 7145979 YP_002402222.1 CDS EC55989_1130 NC_011748.1 1193147 1193344 R hypothetical protein complement(1193147..1193344) Escherichia coli 55989 7145978 YP_002402223.1 CDS phoH NC_011748.1 1193564 1194487 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8444794, 2160940; Product type pe : enzyme; hypothetical protein 1193564..1194487 Escherichia coli 55989 7144530 YP_002402224.1 CDS pgaD NC_011748.1 1194537 1194950 R in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export; PGA biosynthesis protein complement(1194537..1194950) Escherichia coli 55989 7147182 YP_002402225.1 CDS pgaC NC_011748.1 1194952 1196277 R predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein; N-glycosyltransferase complement(1194952..1196277) Escherichia coli 55989 7147149 YP_002402226.1 CDS pgaB NC_011748.1 1196270 1198288 R in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export; outer membrane N-deacetylase complement(1196270..1198288) Escherichia coli 55989 7147148 YP_002402227.1 CDS pgaA NC_011748.1 1198297 1200720 R outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia; outer membrane protein PgaA complement(1198297..1200720) Escherichia coli 55989 7147147 YP_002402228.1 CDS insA NC_011748.1 1201027 1201302 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 1201027..1201302 Escherichia coli 55989 7147146 YP_002402229.1 CDS insB NC_011748.1 1201221 1201724 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 1201221..1201724 Escherichia coli 55989 7146573 YP_002402230.1 CDS EC55989_1138 NC_011748.1 1201775 1202902 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10 1201775..1202902 Escherichia coli 55989 7146585 YP_002402231.1 CDS insF NC_011748.1 1204591 1205457 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin; IS3 element protein InsF complement(1204591..1205457) Escherichia coli 55989 7148284 YP_002402232.1 CDS insE NC_011748.1 1205454 1205762 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin; IS3 element protein InsE complement(1205454..1205762) Escherichia coli 55989 7146594 YP_002402233.1 CDS EC55989_1143 NC_011748.1 1205856 1206347 D hypothetical protein 1205856..1206347 Escherichia coli 55989 7146592 YP_002402234.1 CDS ycdU NC_011748.1 1206344 1207330 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1206344..1207330 Escherichia coli 55989 7144532 YP_002402235.1 CDS ycdW NC_011748.1 1208025 1208963 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11237876, 10493123; Product type e : enzyme; 2-ketoacid reductase 1208025..1208963 Escherichia coli 55989 7145400 YP_002402236.1 CDS ycdX NC_011748.1 1209018 1209755 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12661000; Product type pe : enzyme; hydrolase 1209018..1209755 Escherichia coli 55989 7148286 YP_002402237.1 CDS ycdY NC_011748.1 1209779 1210333 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1209779..1210333 Escherichia coli 55989 7148287 YP_002402238.1 CDS ycdZ NC_011748.1 1210435 1210926 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1210435..1210926 Escherichia coli 55989 7148288 YP_002402239.1 CDS csgG NC_011748.1 1210990 1211823 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8817489; Product type lp : lipoprotein; outer membrane lipoprotein involved in curli production assembly/transport complement(1210990..1211823) Escherichia coli 55989 7148289 YP_002402240.1 CDS csgF NC_011748.1 1211850 1212266 R nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgF complement(1211850..1212266) Escherichia coli 55989 7145774 YP_002402241.1 CDS csgE NC_011748.1 1212291 1212680 R chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex; curli assembly protein CsgE complement(1212291..1212680) Escherichia coli 55989 7145773 YP_002402242.1 CDS csgD NC_011748.1 1212685 1213335 R activates the csgBA and csgDEFG operons involved in biofilm formation; DNA-binding transcriptional regulator CsgD complement(1212685..1213335) Escherichia coli 55989 7145772 YP_002402243.1 CDS csgB NC_011748.1 1214089 1214544 D CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface; curlin minor subunit 1214089..1214544 Escherichia coli 55989 7145771 YP_002402244.1 CDS csgA NC_011748.1 1214585 1215040 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89201357, 93023873, 1677357, 8459772, 8817489, 1357528; Product type s : structure; cryptic curlin major subunit 1214585..1215040 Escherichia coli 55989 7145769 YP_002402245.1 CDS csgC NC_011748.1 1215099 1215431 D involved in autoagglutination of curliated cells; not involved in production of curli fibers; autoagglutination protein 1215099..1215431 Escherichia coli 55989 7145768 YP_002402246.1 CDS ymdB NC_011748.1 1215957 1216490 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1215957..1216490 Escherichia coli 55989 7149268 YP_002402247.1 CDS ymdC NC_011748.1 1216492 1217913 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase 1216492..1217913 Escherichia coli 55989 7149269 YP_002402248.1 CDS mdoC NC_011748.1 1217921 1219078 R required for the transfer of succinyl residues to the glucan backbone; glucans biosynthesis protein complement(1217921..1219078) Escherichia coli 55989 7149270 YP_002402249.1 CDS EC55989_1161 NC_011748.1 1219123 1219266 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1219123..1219266) Escherichia coli 55989 7146798 YP_002402250.1 CDS EC55989_1162 NC_011748.1 1219270 1219428 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1219270..1219428) Escherichia coli 55989 7144533 YP_002402251.1 CDS mdoG NC_011748.1 1219472 1221007 D involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan; glucan biosynthesis protein G 1219472..1221007 Escherichia coli 55989 7144534 YP_002402252.1 CDS mdoH NC_011748.1 1221000 1223543 D necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space; glucosyltransferase MdoH 1221000..1223543 Escherichia coli 55989 7146800 YP_002402253.1 CDS yceK NC_011748.1 1223716 1223943 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 1223716..1223943 Escherichia coli 55989 7146801 YP_002402254.1 CDS msyB NC_011748.1 1223944 1224318 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165719; hypothetical protein complement(1223944..1224318) Escherichia coli 55989 7148298 YP_002402255.1 CDS mdtG NC_011748.1 1224401 1225627 R Confers resistance to fosfomycin and deoxycholate; drug efflux system protein MdtG complement(1224401..1225627) Escherichia coli 55989 7146912 YP_002402256.1 CDS lpxL NC_011748.1 1225799 1226719 R Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis lauroyl acyltransferase complement(1225799..1226719) Escherichia coli 55989 7146808 YP_002402257.1 CDS yceA NC_011748.1 1226944 1227996 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1840644; hypothetical protein 1226944..1227996 Escherichia coli 55989 7146741 YP_002402258.1 CDS yceI NC_011748.1 1228038 1228613 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15741337, 11298273, 1840644, 9298646; Product type c : carrier; hypothetical protein complement(1228038..1228613) Escherichia coli 55989 7148290 YP_002402259.1 CDS yceJ NC_011748.1 1228617 1229183 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; cytochrome b561 complement(1228617..1229183) Escherichia coli 55989 7148296 YP_002402260.1 CDS solA NC_011748.1 1229605 1230723 R catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids; N-methyltryptophan oxidase complement(1229605..1230723) Escherichia coli 55989 7148297 YP_002402261.1 CDS bssS NC_011748.1 1230838 1231092 R BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing; biofilm formation regulatory protein BssS complement(1230838..1231092) Escherichia coli 55989 7147678 YP_002402262.2 CDS dinI NC_011748.1 1231382 1231627 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11230150, 11152126; Product type f : factor; DNA damage-inducible protein I complement(1231382..1231627) Escherichia coli 55989 7145638 YP_002402263.1 CDS pyrC NC_011748.1 1231701 1232747 R catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis; dihydroorotase complement(1231701..1232747) Escherichia coli 55989 7145918 YP_002402264.1 CDS yceB NC_011748.1 1232853 1233413 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein complement(1232853..1233413) Escherichia coli 55989 7147318 YP_002402265.1 CDS grxB NC_011748.1 1233547 1234194 R cofactor involved in the reduction of disulfides; glutaredoxin complement(1233547..1234194) Escherichia coli 55989 7148291 YP_002402266.1 CDS mdtH NC_011748.1 1234258 1235466 R Confers resistance to norfloxacin and enoxacin; multidrug resistance protein MdtH complement(1234258..1235466) Escherichia coli 55989 7146371 YP_002402267.1 CDS rimJ NC_011748.1 1235702 1236286 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88121676, 90136529, 1356970; Product type e : enzyme; ribosomal-protein-S5-alanine N-acetyltransferase 1235702..1236286 Escherichia coli 55989 7146809 YP_002402268.1 CDS yceH NC_011748.1 1236297 1236944 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1356970, 2828880; hypothetical protein 1236297..1236944 Escherichia coli 55989 7147419 YP_002402269.1 CDS mviM NC_011748.1 1236946 1237869 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase with NAD(P)-binding Rossmann-fold domain 1236946..1237869 Escherichia coli 55989 7148295 YP_002402270.1 CDS mviN NC_011748.1 1237979 1239514 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1237979..1239514 Escherichia coli 55989 7146937 YP_002402271.1 CDS flgN NC_011748.1 1239554 1239970 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10320579; Product type f : factor; export chaperone for FlgK and FlgL complement(1239554..1239970) Escherichia coli 55989 7146938 YP_002402272.1 CDS flgM NC_011748.1 1239975 1240268 R regulates the flagellar specific sigma28 transcription factor; anti-sigma-28 factor FlgM complement(1239975..1240268) Escherichia coli 55989 7146137 YP_002402273.1 CDS flgA NC_011748.1 1240344 1241003 R required for the assembly of the flagellar basal body P-ring; flagellar basal body P-ring biosynthesis protein FlgA complement(1240344..1241003) Escherichia coli 55989 7146136 YP_002402274.1 CDS flgB NC_011748.1 1241158 1241574 D with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella; flagellar basal-body rod protein FlgB 1241158..1241574 Escherichia coli 55989 7146124 YP_002402275.1 CDS flgC NC_011748.1 1241578 1241982 D with FlgF and B makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgC 1241578..1241982 Escherichia coli 55989 7146125 YP_002402276.1 CDS flgD NC_011748.1 1241994 1242689 D acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production; flagellar basal body rod modification protein 1241994..1242689 Escherichia coli 55989 7146126 YP_002402277.1 CDS flgE NC_011748.1 1242714 1243919 D the hook connects flagellar basal body to the flagellar filament; flagellar hook protein FlgE 1242714..1243919 Escherichia coli 55989 7146127 YP_002402278.1 CDS flgF NC_011748.1 1243939 1244694 D FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod; flagellar basal body rod protein FlgF 1243939..1244694 Escherichia coli 55989 7146128 YP_002402279.1 CDS flgG NC_011748.1 1244866 1245648 D makes up the distal portion of the flagellar basal body rod; flagellar basal body rod protein FlgG 1244866..1245648 Escherichia coli 55989 7146129 YP_002402280.1 CDS flgH NC_011748.1 1245701 1246399 D part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod; flagellar basal body L-ring protein 1245701..1246399 Escherichia coli 55989 7146130 YP_002402281.1 CDS flgI NC_011748.1 1246411 1247508 D part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum; flagellar basal body P-ring protein 1246411..1247508 Escherichia coli 55989 7146131 YP_002402282.1 CDS flgJ NC_011748.1 1247508 1248449 D Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space; flagellar rod assembly protein/muramidase FlgJ 1247508..1248449 Escherichia coli 55989 7146132 YP_002402283.1 CDS flgK NC_011748.1 1248515 1250158 D with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook; flagellar hook-associated protein FlgK 1248515..1250158 Escherichia coli 55989 7146133 YP_002402284.1 CDS flgL NC_011748.1 1250170 1251123 D with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes; flagellar hook-associated protein FlgL 1250170..1251123 Escherichia coli 55989 7146134 YP_002402285.1 CDS rne NC_011748.1 1251320 1254505 R bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase; ribonuclease E complement(1251320..1254505) Escherichia coli 55989 7146135 YP_002402286.1 CDS rluC NC_011748.1 1255078 1256037 D catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA; 23S rRNA pseudouridylate synthase C 1255078..1256037 Escherichia coli 55989 7145302 YP_002402287.1 CDS yceF NC_011748.1 1256149 1256733 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(1256149..1256733) Escherichia coli 55989 7147428 YP_002402288.1 CDS yceD NC_011748.1 1256932 1257453 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 90008815, 1447160; hypothetical protein 1256932..1257453 Escherichia coli 55989 7147699 YP_002402289.1 CDS rpmF NC_011748.1 1257505 1257678 D some L32 proteins have zinc finger motifs consisting of CXXC while others do not; 50S ribosomal protein L32 1257505..1257678 Escherichia coli 55989 7148292 YP_002402290.1 CDS plsX NC_011748.1 1257759 1258829 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY; glycerol-3-phosphate acyltransferase PlsX 1257759..1258829 Escherichia coli 55989 7147491 YP_002402291.1 CDS fabH NC_011748.1 1258897 1259850 D FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs; 3-oxoacyl-ACP synthase 1258897..1259850 Escherichia coli 55989 7147197 YP_002402292.1 CDS fabD NC_011748.1 1259866 1260795 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052166, 92183950, 92210530, 92234941, 7700236, 7768883, 9298646; Product type e : enzyme; malonyl-CoA-[acyl-carrier-protein] transacylase 1259866..1260795 Escherichia coli 55989 7146051 YP_002402293.1 CDS fabG NC_011748.1 1260808 1261542 D catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis; 3-ketoacyl-ACP reductase 1260808..1261542 Escherichia coli 55989 7146048 YP_002402294.1 CDS acpP NC_011748.1 1261753 1261989 D carries the fatty acid chain in fatty acid biosynthesis; acyl carrier protein 1261753..1261989 Escherichia coli 55989 7146050 YP_002402295.1 CDS fabF NC_011748.1 1262077 1263318 D FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase 1262077..1263318 Escherichia coli 55989 7145441 YP_002402296.1 CDS pabC NC_011748.1 1263438 1264247 D catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate; 4-amino-4-deoxychorismate lyase 1263438..1264247 Escherichia coli 55989 7146049 YP_002402297.1 CDS yceG NC_011748.1 1264250 1265272 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; hypothetical protein 1264250..1265272 Escherichia coli 55989 7147108 YP_002402298.1 CDS tmk NC_011748.1 1265262 1265903 D catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP); thymidylate kinase 1265262..1265903 Escherichia coli 55989 7148294 YP_002402299.1 CDS holB NC_011748.1 1265900 1266904 D catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA; DNA polymerase III subunit delta' 1265900..1266904 Escherichia coli 55989 7147807 YP_002402300.1 CDS ycfH NC_011748.1 1266915 1267712 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8505303, 8509334, 10747959; Product type pe : enzyme; metallodependent hydrolase 1266915..1267712 Escherichia coli 55989 7146454 YP_002402301.1 CDS ptsG NC_011748.1 1268007 1269440 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucose-specific transporter subunit IIBC 1268007..1269440 Escherichia coli 55989 7148300 YP_002402302.1 CDS fhuE NC_011748.1 1269500 1271689 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90286919, 3032906, 10529396; Product type t : transporter; ferric-rhodotorulic acid outer membrane transporter complement(1269500..1271689) Escherichia coli 55989 7147286 YP_002402303.1 CDS hinT NC_011748.1 1272023 1272382 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15703176, 10493123, 2162465; Product type e : enzyme; purine nucleoside phosphoramidase 1272023..1272382 Escherichia coli 55989 7146103 YP_002402304.1 CDS ycfL NC_011748.1 1272385 1272762 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1272385..1272762 Escherichia coli 55989 7146427 YP_002402305.1 CDS ycfM NC_011748.1 1272776 1273417 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; outer membrane lipoprotein 1272776..1273417 Escherichia coli 55989 7148302 YP_002402306.1 CDS thiK NC_011748.1 1273398 1274222 D catalyzes the phosphorylation of thiamine to thiamine phosphate; thiamine kinase 1273398..1274222 Escherichia coli 55989 7148303 YP_002402307.1 CDS nagZ NC_011748.1 1274233 1275258 D hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides; beta-hexosaminidase 1274233..1275258 Escherichia coli 55989 7148304 YP_002402308.1 CDS ycfP NC_011748.1 1275281 1275823 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1275281..1275823 Escherichia coli 55989 7146953 YP_002402309.1 CDS ndh NC_011748.1 1276231 1277535 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766919, 20130027, 81256452, 92296775, 94042945, 99441207, 6265208; Product type e : enzyme; respiratory NADH dehydrogenase 2/cupric reductase 1276231..1277535 Escherichia coli 55989 7148305 YP_002402310.1 CDS ycfJ NC_011748.1 1277745 1278284 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6265208, 7984428; hypothetical protein 1277745..1278284 Escherichia coli 55989 7146981 YP_002402311.1 CDS ycfQ NC_011748.1 1278346 1278978 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(1278346..1278978) Escherichia coli 55989 7148301 YP_002402312.1 CDS ycfR NC_011748.1 1279219 1279476 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; hypothetical protein 1279219..1279476 Escherichia coli 55989 7148306 YP_002402313.1 CDS ycfS NC_011748.1 1279559 1280521 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1279559..1280521) Escherichia coli 55989 7148307 YP_002402314.1 CDS mfd NC_011748.1 1280665 1284111 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14602898, 90158497, 92107993, 8465200; Product type f : factor; transcription-repair coupling factor complement(1280665..1284111) Escherichia coli 55989 7148308 YP_002402315.1 CDS ycfT NC_011748.1 1284239 1285312 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(1284239..1285312) Escherichia coli 55989 7146838 YP_002402316.1 CDS lolC NC_011748.1 1285574 1286773 D part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolC 1285574..1286773 Escherichia coli 55989 7148309 YP_002402317.1 CDS lolD NC_011748.1 1286766 1287467 D outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone; lipoprotein transporter ATP-binding subunit 1286766..1287467 Escherichia coli 55989 7146717 YP_002402318.1 CDS lolE NC_011748.1 1287467 1288711 D part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane; outer membrane-specific lipoprotein transporter subunit LolE 1287467..1288711 Escherichia coli 55989 7146718 YP_002402319.1 CDS ycfX NC_011748.1 1288740 1289651 D catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine; N-acetyl-D-glucosamine kinase 1288740..1289651 Escherichia coli 55989 7146719 YP_002402320.1 CDS cobB NC_011748.1 1289667 1290488 D Modulates the activities of several enzymes which are inactive in their acetylated form; NAD-dependent deacetylase 1289667..1290488 Escherichia coli 55989 7148310 YP_002402321.1 CDS ycfZ NC_011748.1 1290627 1291349 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(1290627..1291349) Escherichia coli 55989 7145735 YP_002402322.1 CDS EC55989_1234 NC_011748.1 1291412 1291882 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1291412..1291882) Escherichia coli 55989 7148311 YP_002402323.1 CDS potD NC_011748.1 1291931 1292977 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate; spermidine/putrescine ABC transporter substrate-binding protein complement(1291931..1292977) Escherichia coli 55989 7144535 YP_002402324.1 CDS potC NC_011748.1 1292974 1293768 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component; spermidine/putrescine ABC transporter membrane protein complement(1292974..1293768) Escherichia coli 55989 7147212 YP_002402325.1 CDS potB NC_011748.1 1293765 1294592 R can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component; spermidine/putrescine ABC transporter membrane protein complement(1293765..1294592) Escherichia coli 55989 7147211 YP_002402326.1 CDS potA NC_011748.1 1294606 1295742 R functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase; putrescine/spermidine ABC transporter ATPase complement(1294606..1295742) Escherichia coli 55989 7147210 YP_002402327.1 CDS EC55989_1239 NC_011748.1 1295721 1295972 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1295721..1295972) Escherichia coli 55989 7147209 YP_002402328.1 CDS pepT NC_011748.1 1295950 1297221 D catalyzes the release of the N-terminal amino acid from a tripeptide; peptidase T 1295950..1297221 Escherichia coli 55989 7144536 YP_002402329.1 CDS ycfD NC_011748.1 1297367 1298488 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1297367..1298488) Escherichia coli 55989 7147137 YP_002402330.1 CDS phoQ NC_011748.1 1298564 1300024 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105017; Product type r : regulator; sensor protein PhoQ complement(1298564..1300024) Escherichia coli 55989 7148299 YP_002402331.1 CDS phoP NC_011748.1 1300024 1300695 R response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress; DNA-binding transcriptional regulator PhoP complement(1300024..1300695) Escherichia coli 55989 7147184 YP_002402332.1 CDS purB NC_011748.1 1300863 1302233 R Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide; adenylosuccinate lyase complement(1300863..1302233) Escherichia coli 55989 7147183 YP_002402333.1 CDS hflD NC_011748.1 1302237 1302878 R HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis; hypothetical protein complement(1302237..1302878) Escherichia coli 55989 7147293 YP_002402334.1 CDS mnmA NC_011748.1 1302914 1304020 R catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs; tRNA-specific 2-thiouridylase MnmA complement(1302914..1304020) Escherichia coli 55989 7146421 YP_002402335.1 CDS ymfB NC_011748.1 1304074 1304535 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15292217; Product type e : enzyme; bifunctional thiamin pyrimidine pyrophosphate hydrolase and thiamin pyrophosphate hydrolase complement(1304074..1304535) Escherichia coli 55989 7147849 YP_002402336.1 CDS ymfC NC_011748.1 1304545 1305198 R catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase E complement(1304545..1305198) Escherichia coli 55989 7149272 YP_002402337.1 CDS icd NC_011748.1 1305370 1306620 D Converts isocitrate to alpha ketoglutarate; isocitrate dehydrogenase 1305370..1306620 Escherichia coli 55989 7149273 YP_002402338.1 CDS elbA NC_011748.1 1306723 1307046 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9603997; hypothetical protein complement(1306723..1307046) Escherichia coli 55989 7146537 YP_002402339.1 CDS ycgX NC_011748.1 1307742 1308146 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1307742..1308146) Escherichia coli 55989 7145987 YP_002402340.1 CDS ycgE NC_011748.1 1308367 1309098 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(1308367..1309098) Escherichia coli 55989 7148323 YP_002402341.1 CDS ycgF NC_011748.1 1309303 1310514 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16533062, 15453820; Product type pe : enzyme; cyclic-di-GMP phosphodiesterase; blue-light sensing protein using FAD (BLUF) complement(1309303..1310514) Escherichia coli 55989 7148313 YP_002402342.1 CDS ycgZ NC_011748.1 1310828 1311064 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1310828..1311064 Escherichia coli 55989 7148314 YP_002402343.1 CDS ymgA NC_011748.1 1311107 1311379 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1311107..1311379 Escherichia coli 55989 7148325 YP_002402344.1 CDS ymgB NC_011748.1 1311408 1311674 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1311408..1311674 Escherichia coli 55989 7149275 YP_002402345.1 CDS ymgC NC_011748.1 1311787 1312035 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1311787..1312035 Escherichia coli 55989 7149276 YP_002402346.1 CDS ycgG NC_011748.1 1312367 1313890 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1312367..1313890 Escherichia coli 55989 7149277 YP_002402347.1 CDS ymgF NC_011748.1 1314022 1314240 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1314022..1314240 Escherichia coli 55989 7148315 YP_002402348.1 CDS EC55989_1260 NC_011748.1 1314640 1314849 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1314640..1314849 Escherichia coli 55989 7149280 YP_002402349.1 CDS insA NC_011748.1 1315056 1315331 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 1315056..1315331 Escherichia coli 55989 7144537 YP_002402350.1 CDS insB NC_011748.1 1315250 1315753 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 1315250..1315753 Escherichia coli 55989 7146574 YP_002402351.1 CDS EC55989_1263 NC_011748.1 1315755 1318064 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; Outer membrane autotransporter barrel, pectin lyase fold 1315755..1318064 Escherichia coli 55989 7146586 YP_002402352.1 CDS ymgD NC_011748.1 1318121 1318450 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1318121..1318450) Escherichia coli 55989 7144538 YP_002402353.1 CDS ymgG NC_011748.1 1318460 1318735 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1318460..1318735) Escherichia coli 55989 7149278 YP_002402354.1 CDS EC55989_1266 NC_011748.1 1319281 1319724 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1319281..1319724 Escherichia coli 55989 7149281 YP_002402355.1 CDS minE NC_011748.1 1320096 1320362 R works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell; cell division topological specificity factor MinE complement(1320096..1320362) Escherichia coli 55989 7144539 YP_002402356.1 CDS minD NC_011748.1 1320366 1321178 R ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums; cell division inhibitor MinD complement(1320366..1321178) Escherichia coli 55989 7146859 YP_002402357.1 CDS minC NC_011748.1 1321202 1321897 R blocks the formation of polar Z-ring septums; septum formation inhibitor complement(1321202..1321897) Escherichia coli 55989 7146858 YP_002402358.1 CDS ycgJ NC_011748.1 1322417 1322785 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1322417..1322785 Escherichia coli 55989 7146857 YP_002402359.1 CDS ycgK NC_011748.1 1322905 1323306 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1322905..1323306) Escherichia coli 55989 7148316 YP_002402360.1 CDS ycgL NC_011748.1 1323515 1323841 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1323515..1323841 Escherichia coli 55989 7148317 YP_002402361.1 CDS ycgM NC_011748.1 1323913 1324572 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15551868; Product type pe : enzyme; hypothetical protein 1323913..1324572 Escherichia coli 55989 7148318 YP_002402362.1 CDS ycgN NC_011748.1 1324664 1325110 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1324664..1325110 Escherichia coli 55989 7148319 YP_002402363.1 CDS EC55989_1277 NC_011748.1 1326117 1326371 R hypothetical protein complement(1326117..1326371) Escherichia coli 55989 7146446 YP_002402364.1 CDS umuD NC_011748.1 1326600 1327019 D binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuD 1326600..1327019 Escherichia coli 55989 7145648 YP_002402365.1 CDS umuC NC_011748.1 1327019 1328287 D binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization; DNA polymerase V subunit UmuC 1327019..1328287 Escherichia coli 55989 7147922 YP_002402366.1 CDS dsbB NC_011748.1 1328333 1328863 R disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein; disulfide bond formation protein B complement(1328333..1328863) Escherichia coli 55989 7147921 YP_002402367.1 CDS nhaB NC_011748.1 1329009 1330550 R involved in regulation of intracellular pH under alkaline conditions; sodium/proton antiporter complement(1329009..1330550) Escherichia coli 55989 7145951 YP_002402368.1 CDS fadR NC_011748.1 1330772 1331491 D Multifunctional regulator of fatty acid metabolism; fatty acid metabolism regulator 1330772..1331491 Escherichia coli 55989 7146992 YP_002402369.1 CDS ycgB NC_011748.1 1331543 1333075 R Evidence 4 : Homologs of previously reported genes of unknown function; SpoVR family protein complement(1331543..1333075) Escherichia coli 55989 7146061 YP_002402370.1 CDS dadA NC_011748.1 1333405 1334703 D catalyzes the oxidative deamination of D-amino acids; D-amino acid dehydrogenase small subunit 1333405..1334703 Escherichia coli 55989 7148312 YP_002402371.1 CDS dadX NC_011748.1 1334713 1335783 D catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA; alanine racemase 1334713..1335783 Escherichia coli 55989 7145845 YP_002402372.1 CDS cvrA NC_011748.1 1336169 1337905 R the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli; potassium/proton antiporter complement(1336169..1337905) Escherichia coli 55989 7145846 YP_002402373.1 CDS ldcA NC_011748.1 1338000 1338914 R catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine; L,D-carboxypeptidase A complement(1338000..1338914) Escherichia coli 55989 7145801 YP_002402374.1 CDS emtA NC_011748.1 1339014 1339625 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98317285; Product type e : enzyme; lytic murein endotransglycosylase E 1339014..1339625 Escherichia coli 55989 7146680 YP_002402375.1 CDS ycgR NC_011748.1 1339627 1340361 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11031114; Product type cp : cell process; protein involved in flagellar function complement(1339627..1340361) Escherichia coli 55989 7145996 YP_002402376.1 CDS ymgE NC_011748.1 1340562 1340816 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; inner membrane protein with transglycosylase-associated domain 1340562..1340816 Escherichia coli 55989 7148321 YP_002402377.1 CDS ycgY NC_011748.1 1340994 1341434 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1340994..1341434 Escherichia coli 55989 7149279 YP_002402378.1 CDS treA NC_011748.1 1341513 1343210 R periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell; trehalase complement(1341513..1343210) Escherichia coli 55989 7148324 YP_002402379.1 CDS dhaH NC_011748.1 1343530 1344948 R phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL; dihydroxyacetone kinase subunit DhaM complement(1343530..1344948) Escherichia coli 55989 7147835 YP_002402380.1 CDS dhaL NC_011748.1 1344959 1345591 R with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone; dihydroxyacetone kinase subunit DhaL complement(1344959..1345591) Escherichia coli 55989 7145902 YP_002402381.1 CDS dhaK NC_011748.1 1345602 1346672 R with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase; dihydroxyacetone kinase subunit DhaK complement(1345602..1346672) Escherichia coli 55989 7145904 YP_002402382.1 CDS dhaR NC_011748.1 1346900 1348819 D Positively regulates the dhaKLM operon from a sigma-70 promoter; DNA-binding transcriptional regulator DhaR 1346900..1348819 Escherichia coli 55989 7145903 YP_002402383.1 CDS ycgV NC_011748.1 1348919 1351786 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15659678; Product type pf : factor; adhesin; autotransporter complement(1348919..1351786) Escherichia coli 55989 7145905 YP_002402384.1 CDS ychF NC_011748.1 1352555 1353646 R translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1; GTP-dependent nucleic acid-binding protein EngD complement(1352555..1353646) Escherichia coli 55989 7148322 YP_002402385.1 CDS pth NC_011748.1 1353763 1354347 R Enables the recycling of peptidyl-tRNAs produced at termination of translation; peptidyl-tRNA hydrolase complement(1353763..1354347) Escherichia coli 55989 7148328 YP_002402386.1 CDS ychH NC_011748.1 1354625 1354903 D YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function; hypothetical protein 1354625..1354903 Escherichia coli 55989 7147282 YP_002402387.1 CDS ychM NC_011748.1 1354958 1356637 R role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport; sulfate transporter YchM complement(1354958..1356637) Escherichia coli 55989 7148330 YP_002402388.1 CDS prsA NC_011748.1 1356762 1357709 R catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP; ribose-phosphate pyrophosphokinase complement(1356762..1357709) Escherichia coli 55989 7148332 YP_002402389.1 CDS ipk NC_011748.1 1357860 1358711 R An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase complement(1357860..1358711) Escherichia coli 55989 7147267 YP_002402390.1 CDS lolB NC_011748.1 1358711 1359334 R Incorporates lipoproteins in the outer membrane after they are released by the LolA protein; outer membrane lipoprotein LolB complement(1358711..1359334) Escherichia coli 55989 7146628 YP_002402391.1 CDS hemA NC_011748.1 1359548 1360804 D catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins; glutamyl-tRNA reductase 1359548..1360804 Escherichia coli 55989 7146716 YP_002402392.1 CDS prfA NC_011748.1 1360846 1361928 D recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2; peptide chain release factor 1 1360846..1361928 Escherichia coli 55989 7146407 YP_002402393.1 CDS prmC NC_011748.1 1361928 1362761 D HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase 1361928..1362761 Escherichia coli 55989 7147240 YP_002402394.1 CDS ychQ NC_011748.1 1362758 1363150 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : regulator; transcriptional regulator 1362758..1363150 Escherichia coli 55989 7147251 YP_002402395.1 CDS ychA NC_011748.1 1363154 1363963 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10322010; Product type pr : regulator; transcriptional regulator 1363154..1363963 Escherichia coli 55989 7148335 YP_002402396.1 CDS kdsA NC_011748.1 1363999 1364853 D catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis; 2-dehydro-3-deoxyphosphooctonate aldolase 1363999..1364853 Escherichia coli 55989 7148326 YP_002402397.1 CDS ldrB NC_011748.1 1365002 1365169 R Evidence 2b : Function of strongly homologous gene; Product type f : factor; small toxic polypeptide complement(1365002..1365169) Escherichia coli 55989 7146659 YP_002402398.1 CDS ldrB NC_011748.1 1365538 1365645 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type f : factor; toxic polypeptide, small complement(1365538..1365645) Escherichia coli 55989 7147353 YP_002402399.1 CDS chaA NC_011748.1 1366050 1367150 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93266586, 94193576, 94292460; Product type t : transporter; calcium/sodium:proton antiporter complement(1366050..1367150) Escherichia coli 55989 7147354 YP_002402400.1 CDS chaB NC_011748.1 1367420 1367650 D in Escherichia coli this protein ly regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions; cation transport regulator 1367420..1367650 Escherichia coli 55989 7145688 YP_002402401.1 CDS chaC NC_011748.1 1367787 1368503 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type r : regulator; regulatory protein for cation transport 1367787..1368503 Escherichia coli 55989 7145689 YP_002402402.1 CDS ychN NC_011748.1 1368547 1368900 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1368547..1368900) Escherichia coli 55989 7145690 YP_002402403.1 CDS ychP NC_011748.1 1369226 1370479 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pf : factor; hypothetical protein 1369226..1370479 Escherichia coli 55989 7148333 YP_002402404.1 CDS narL NC_011748.1 1370480 1371130 R two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase; transcriptional regulator NarL complement(1370480..1371130) Escherichia coli 55989 7148334 YP_002402405.1 CDS narX NC_011748.1 1371123 1372919 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92276349, 92374842, 94083940, 2649492, 2657652, 2668029; Product type r : regulator; nitrate/nitrite sensor protein NarX complement(1371123..1372919) Escherichia coli 55989 7146972 YP_002402406.1 CDS narK NC_011748.1 1373258 1374649 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91258310, 2657652, 2668029; Product type t : transporter; nitrate/nitrite transporter 1373258..1374649 Escherichia coli 55989 7146978 YP_002402407.1 CDS narG NC_011748.1 1375165 1378908 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 2233673, 2668029, 2995309, 3053688, 3308846, 6094247; Product type e : enzyme; nitrate reductase 1 subunit alpha 1375165..1378908 Escherichia coli 55989 7146971 YP_002402408.1 CDS narH NC_011748.1 1378905 1380443 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 74167294, 89384449, 92121125, 1321049, 2832376, 3053688, 8383531, 8388253, 8664273, 9516445; Product type c : carrier; nitrate reductase 1 subunit, beta (Fe-S) 1378905..1380443 Escherichia coli 55989 7146967 YP_002402409.1 CDS narJ NC_011748.1 1380440 1381150 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89384449, 92121125, 9632249, 2832376; Product type f : factor; molybdenum-cofactor-assembly chaperone subunit (delta subunit) of nitrate reductase 1 1380440..1381150 Escherichia coli 55989 7146968 YP_002402410.1 CDS narI NC_011748.1 1381150 1381827 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 75114694, 89384449, 92121125, 2832376, 3053688; Product type c : carrier; nitrate reductase 1 subunit gamma (cytochrome b(NR)) 1381150..1381827 Escherichia coli 55989 7146970 YP_002402412.1 CDS purU NC_011748.1 1382552 1383394 R produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine; formyltetrahydrofolate deformylase complement(1382552..1383394) Escherichia coli 55989 7145398 YP_002402413.1 CDS ychJ NC_011748.1 1383444 1383902 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1383444..1383902) Escherichia coli 55989 7147305 YP_002402414.1 CDS rssA NC_011748.1 1383976 1384920 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 1383976..1384920 Escherichia coli 55989 7148331 YP_002402415.1 CDS rssB NC_011748.1 1385012 1386025 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339606, 12912910, 9495753; Product type r : regulator; response regulator of RpoS 1385012..1386025 Escherichia coli 55989 7147541 YP_002402416.1 CDS galU NC_011748.1 1386227 1387135 D together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase 1386227..1387135 Escherichia coli 55989 7147542 YP_002402417.1 CDS hns NC_011748.1 1387279 1387692 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89056689, 94335643, 95267838, 95286558, 99355427, 2404280, 11298273; Product type r : regulator; global DNA-binding transcriptional dual regulator H-NS complement(1387279..1387692) Escherichia coli 55989 7146255 YP_002402418.1 CDS tdk NC_011748.1 1388298 1388915 D catalyzes the formation of thymidine 5'-phosphate from thymidine; thymidine kinase 1388298..1388915 Escherichia coli 55989 7146448 YP_002402419.1 CDS EC55989_1334 NC_011748.1 1389197 1389739 R hypothetical protein complement(1389197..1389739) Escherichia coli 55989 7147772 YP_002402420.1 CDS EC55989_1335 NC_011748.1 1389743 1389973 R hypothetical protein complement(1389743..1389973) Escherichia coli 55989 7144542 YP_002402421.1 CDS ychG NC_011748.1 1389912 1390097 R Evidence 4 : Homologs of previously reported genes of unknown function; transposase complement(1389912..1390097) Escherichia coli 55989 7144543 YP_002402422.1 CDS adhE NC_011748.1 1390221 1392896 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12783863, 4301680, 89291706, 91200315; Product type e : enzyme; bifunctional acetaldehyde-CoA/alcohol dehydrogenase complement(1390221..1392896) Escherichia coli 55989 7148329 YP_002402423.1 CDS ychE NC_011748.1 1393373 1394020 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 1393373..1394020 Escherichia coli 55989 7145455 YP_002402424.1 CDS oppA NC_011748.1 1394758 1396389 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20256410, 86111605, 90256748, 92325017, 2015910, 9298646, 9600841, 2187863, 8740179, 9740056, 10972807; Product type t : transporter; oligopeptide transporter subunit ; periplasmic-binding component of ABC superfamily 1394758..1396389 Escherichia coli 55989 7144544 YP_002402425.1 CDS oppB NC_011748.1 1396475 1397395 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606, 93106975, 2187863; Product type t : transporter; oligopeptide transporter permease 1396475..1397395 Escherichia coli 55989 7147075 YP_002402426.1 CDS oppC NC_011748.1 1397410 1398318 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide transporter subunit ; membrane component of ABC superfamily 1397410..1398318 Escherichia coli 55989 7147076 YP_002402427.1 CDS oppD NC_011748.1 1398330 1399343 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide ABC transporter ATP-binding protein 1398330..1399343 Escherichia coli 55989 7147077 YP_002402428.1 CDS oppF NC_011748.1 1399340 1400344 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86111606; Product type t : transporter; oligopeptide transporter subunit ; ATP-binding component of ABC superfamily 1399340..1400344 Escherichia coli 55989 7147078 YP_002402429.1 CDS yciU NC_011748.1 1400397 1400726 R highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein; dsDNA-mimic protein complement(1400397..1400726) Escherichia coli 55989 7147079 YP_002402430.1 CDS cls NC_011748.1 1400761 1402221 R catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol); cardiolipin synthetase complement(1400761..1402221) Escherichia coli 55989 7148352 YP_002402431.1 CDS EC55989_1347 NC_011748.1 1402253 1402537 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1402253..1402537 Escherichia coli 55989 7145727 YP_002402432.1 CDS kch NC_011748.1 1402592 1403845 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12220501, 12912904, 94224769, 98319474; Product type t : transporter; voltage-gated potassium channel complement(1402592..1403845) Escherichia coli 55989 7144545 YP_002402433.1 CDS yciI NC_011748.1 1404145 1404441 R unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity; hypothetical protein complement(1404145..1404441) Escherichia coli 55989 7146650 YP_002402434.1 CDS tonB NC_011748.1 1404665 1405384 D membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins; transporter 1404665..1405384 Escherichia coli 55989 7148346 YP_002402435.1 CDS yciA NC_011748.1 1405424 1405822 R YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins; acyl-CoA thioester hydrolase complement(1405424..1405822) Escherichia coli 55989 7147817 YP_002402436.1 CDS yciB NC_011748.1 1405927 1406466 R Involved in cell division; probably involved in intracellular septation; intracellular septation protein A complement(1405927..1406466) Escherichia coli 55989 7148336 YP_002402437.1 CDS yciC NC_011748.1 1406496 1407239 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(1406496..1407239) Escherichia coli 55989 7148337 YP_002402438.1 CDS ompW NC_011748.1 1407596 1408234 D receptor for colicin S4; outer membrane protein W 1407596..1408234 Escherichia coli 55989 7148338 YP_002402439.1 CDS EC55989_1355 NC_011748.1 1408280 1409410 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage integrase complement(1408280..1409410) Escherichia coli 55989 7147071 YP_002402440.1 CDS EC55989_1356 NC_011748.1 1409388 1409636 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; phage excisionase complement(1409388..1409636) Escherichia coli 55989 7144546 YP_002402441.1 CDS EC55989_1357 NC_011748.1 1409701 1412172 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; exonuclease from phage origin complement(1409701..1412172) Escherichia coli 55989 7144547 YP_002402442.1 CDS ydfD NC_011748.1 1412265 1412456 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage complement(1412265..1412456) Escherichia coli 55989 7144548 YP_002402443.1 CDS EC55989_1359 NC_011748.1 1412453 1412746 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; regulator of cell division encoded by prophage complement(1412453..1412746) Escherichia coli 55989 7148432 YP_002402444.1 CDS EC55989_1360 NC_011748.1 1412991 1413206 D Evidence 6 : Doubtful CDS; hypothetical protein 1412991..1413206 Escherichia coli 55989 7145912 YP_002402445.1 CDS EC55989_1361 NC_011748.1 1413136 1413402 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1413136..1413402 Escherichia coli 55989 7144550 YP_002402446.1 CDS EC55989_1362 NC_011748.1 1413391 1413741 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1413391..1413741) Escherichia coli 55989 7144551 YP_002402447.1 CDS EC55989_1363 NC_011748.1 1413741 1414049 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1413741..1414049) Escherichia coli 55989 7144552 YP_002402448.1 CDS dicA NC_011748.1 1414086 1414544 R The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown.; transcriptional repressor DicA complement(1414086..1414544) Escherichia coli 55989 7144553 YP_002402449.1 CDS EC55989_1365 NC_011748.1 1414544 1414798 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA-binding transcriptional regulator DicC 1414544..1414798 Escherichia coli 55989 7145907 YP_002402450.1 CDS EC55989_1366 NC_011748.1 1414782 1415303 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1414782..1415303 Escherichia coli 55989 7144554 YP_002402451.1 CDS EC55989_1367 NC_011748.1 1415230 1416249 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1415230..1416249 Escherichia coli 55989 7144555 YP_002402452.1 CDS EC55989_1368 NC_011748.1 1416290 1416712 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1416290..1416712 Escherichia coli 55989 7144556 YP_002402453.1 CDS EC55989_1369 NC_011748.1 1416965 1417864 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 1416965..1417864 Escherichia coli 55989 7144557 YP_002402454.1 CDS ymfD NC_011748.1 1418179 1418838 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; S-adenosyl-L-methionine-dependent methyltransferases complement(1418179..1418838) Escherichia coli 55989 7144558 YP_002402455.1 CDS EC55989_1371 NC_011748.1 1418845 1419552 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1418845..1419552) Escherichia coli 55989 7149274 YP_002402456.1 CDS EC55989_1372 NC_011748.1 1419725 1419892 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(1419725..1419892) Escherichia coli 55989 7144559 YP_002402457.1 CDS rem NC_011748.1 1420655 1420906 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2990907; Product type h : extrachromosomal origin; Qin prophage 1420655..1420906 Escherichia coli 55989 7144560 YP_002402458.1 CDS ydfU NC_011748.1 1421253 1422302 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage 1421253..1422302 Escherichia coli 55989 7147371 YP_002402459.1 CDS EC55989_1375 NC_011748.1 1422308 1422508 D Evidence 6 : Doubtful CDS; hypothetical protein 1422308..1422508 Escherichia coli 55989 7148443 YP_002402460.1 CDS EC55989_1376 NC_011748.1 1422315 1422674 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; crossover junction endodeoxyribonuclease rusA (Holliday junction nuclease rusA) (Holliday juction resolvase) (Gp67) 1422315..1422674 Escherichia coli 55989 7144561 YP_002402461.1 CDS Q NC_011748.1 1422665 1423360 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type h : extrachromosomal origin; Antitermination protein Q 1422665..1423360 Escherichia coli 55989 7144562 YP_002402462.1 CDS EC55989_1378 NC_011748.1 1423432 1424271 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; protein kinase from phage origin 1423432..1424271 Escherichia coli 55989 7147326 YP_002402463.1 CDS EC55989_1379 NC_011748.1 1424268 1425011 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; protein phosphatase from phage origin 1424268..1425011 Escherichia coli 55989 7144563 YP_002402464.1 CDS EC55989_1381 NC_011748.1 1426724 1428580 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 1426724..1428580 Escherichia coli 55989 7145327 YP_002402465.1 CDS ydfQ NC_011748.1 1429321 1429854 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane-associated lysozyme; Qin prophage 1429321..1429854 Escherichia coli 55989 7144568 YP_002402466.1 CDS Rz NC_011748.1 1429836 1430309 D Evidence 2b : Function of strongly homologous gene; PubMedId : 2763468; Product type h : extrachromosomal origin; Endopeptidase (Lysis protein Rz) 1429836..1430309 Escherichia coli 55989 7148440 YP_002402467.1 CDS EC55989_1386 NC_011748.1 1430726 1431346 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage regulatory protein 1430726..1431346 Escherichia coli 55989 7147597 YP_002402468.1 CDS EC55989_1387 NC_011748.1 1431288 1432355 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1431288..1432355) Escherichia coli 55989 7144569 YP_002402469.1 CDS EC55989_1388 NC_011748.1 1432470 1432622 D Evidence 6 : Doubtful CDS; Product type h : extrachromosomal origin; hypothetical protein 1432470..1432622 Escherichia coli 55989 7144570 YP_002402470.1 CDS EC55989_1389 NC_011748.1 1432760 1433308 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Terminase small subunit (gp1) 1432760..1433308 Escherichia coli 55989 7144571 YP_002402471.1 CDS EC55989_1390 NC_011748.1 1433238 1435208 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Terminase large subunit (Gp2) 1433238..1435208 Escherichia coli 55989 7144572 YP_002402472.1 CDS EC55989_1391 NC_011748.1 1435192 1435398 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Head stabilization protein (Head protein GP3) 1435192..1435398 Escherichia coli 55989 7144573 YP_002402473.1 CDS EC55989_1392 NC_011748.1 1435395 1436987 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Portal protein (Head protein Gp4) 1435395..1436987 Escherichia coli 55989 7144574 YP_002402474.1 CDS EC55989_1393 NC_011748.1 1436977 1438482 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Head-tail preconnector protein GP5 [Contains: Scaffold protein GP6 (Head protein GP6)] 1436977..1438482 Escherichia coli 55989 7144575 YP_002402475.1 CDS EC55989_1394 NC_011748.1 1438519 1438866 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Head decoration protein (gpD) (Major capsid protein D) 1438519..1438866 Escherichia coli 55989 7144576 YP_002402476.1 CDS EC55989_1395 NC_011748.1 1438924 1439952 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major head protein (Head protein gp7) 1438924..1439952 Escherichia coli 55989 7144577 YP_002402477.1 CDS EC55989_1396 NC_011748.1 1439956 1440387 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein 1439956..1440387 Escherichia coli 55989 7144578 YP_002402478.1 CDS EC55989_1397 NC_011748.1 1440380 1440733 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail attachment protein (Minor capsid protein FII) 1440380..1440733 Escherichia coli 55989 7144579 YP_002402479.1 CDS EC55989_1398 NC_011748.1 1440748 1441323 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein Z (GpZ) 1440748..1441323 Escherichia coli 55989 7144580 YP_002402480.1 CDS EC55989_1399 NC_011748.1 1441320 1441715 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein U 1441320..1441715 Escherichia coli 55989 7144581 YP_002402481.1 CDS EC55989_1400 NC_011748.1 1441723 1442475 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail protein V 1441723..1442475 Escherichia coli 55989 7144582 YP_002402482.1 CDS EC55989_1401 NC_011748.1 1442489 1442920 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein G 1442489..1442920 Escherichia coli 55989 7144583 YP_002402483.1 CDS EC55989_1402 NC_011748.1 1442947 1443360 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein T 1442947..1443360 Escherichia coli 55989 7144584 YP_002402484.1 CDS EC55989_1403 NC_011748.1 1443341 1445914 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein precursor H 1443341..1445914 Escherichia coli 55989 7144585 YP_002402485.1 CDS EC55989_1405 NC_011748.1 1445911 1446240 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein M 1445911..1446240 Escherichia coli 55989 7144586 YP_002402486.1 CDS EC55989_1406 NC_011748.1 1446240 1446938 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein L 1446240..1446938 Escherichia coli 55989 7144587 YP_002402487.1 CDS EC55989_1407 NC_011748.1 1446688 1447692 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; tail fiber component K 1446688..1447692 Escherichia coli 55989 7144588 YP_002402488.1 CDS EC55989_1408 NC_011748.1 1447590 1448270 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail assembly protein I 1447590..1448270 Escherichia coli 55989 7144589 YP_002402489.1 CDS EC55989_1409 NC_011748.1 1448613 1452086 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J 1448613..1452086 Escherichia coli 55989 7144590 YP_002402490.1 CDS EC55989_1410 NC_011748.1 1452154 1452753 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; Lom-like outer membrane protein of phage origin 1452154..1452753 Escherichia coli 55989 7144591 YP_002402491.1 CDS EC55989_1411 NC_011748.1 1452905 1456075 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber protein 1452905..1456075 Escherichia coli 55989 7144592 YP_002402492.1 CDS tfaQ NC_011748.1 1456075 1456659 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; tail fiber chaperone; Qin prophage 1456075..1456659 Escherichia coli 55989 7144593 YP_002402493.1 CDS ybcY NC_011748.1 1456714 1457298 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; AdoMet-dependent methyltransferase; DLP12 prophage complement(1456714..1457298) Escherichia coli 55989 7147778 YP_002402494.1 CDS EC55989_1414 NC_011748.1 1457439 1457708 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber assembly protein 1457439..1457708 Escherichia coli 55989 7148137 YP_002402495.1 CDS yciE NC_011748.1 1458482 1458988 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15388941, 3058546, 8455549; hypothetical protein complement(1458482..1458988) Escherichia coli 55989 7144594 YP_002402496.1 CDS yciF NC_011748.1 1459034 1459534 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3058546, 8455549; hypothetical protein complement(1459034..1459534) Escherichia coli 55989 7148339 YP_002402497.1 CDS yciG NC_011748.1 1459620 1459799 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1459620..1459799) Escherichia coli 55989 7148341 YP_002402498.1 CDS trpA NC_011748.1 1460180 1460986 R catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis; tryptophan synthase subunit alpha complement(1460180..1460986) Escherichia coli 55989 7148343 YP_002402499.1 CDS trpB NC_011748.1 1460986 1462179 R catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate; tryptophan synthase subunit beta complement(1460986..1462179) Escherichia coli 55989 7147850 YP_002402500.1 CDS trpC NC_011748.1 1462191 1463549 R monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate; bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase complement(1462191..1463549) Escherichia coli 55989 7147851 YP_002402501.1 CDS trpD NC_011748.1 1463553 1465148 R bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis; bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase complement(1463553..1465148) Escherichia coli 55989 7147852 YP_002402502.1 CDS trpE NC_011748.1 1465148 1466710 R with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine; anthranilate synthase component I complement(1465148..1466710) Escherichia coli 55989 7147853 YP_002402504.1 CDS yciV NC_011748.1 1466984 1467865 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1466984..1467865 Escherichia coli 55989 7147855 YP_002402505.1 CDS yciO NC_011748.1 1467862 1468482 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1467862..1468482 Escherichia coli 55989 7148353 YP_002402506.1 CDS rluB NC_011748.1 1468556 1469455 D catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA; 23S rRNA pseudouridylate synthase B 1468556..1469455 Escherichia coli 55989 7148350 YP_002402507.1 CDS btuR NC_011748.1 1469495 1470085 R catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide; cob(I)yrinic acid a,c-diamide adenosyltransferase complement(1469495..1470085) Escherichia coli 55989 7147427 YP_002402508.1 CDS yciK NC_011748.1 1470082 1470840 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; short chain dehydrogenase complement(1470082..1470840) Escherichia coli 55989 7145644 YP_002402509.1 CDS EC55989_1428 NC_011748.1 1470884 1471048 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1470884..1471048) Escherichia coli 55989 7148347 YP_002402510.1 CDS sohB NC_011748.1 1471060 1472109 D SohB; periplasmic protein; member of the peptidase S49 family; periplasmic protease 1471060..1472109 Escherichia coli 55989 7144595 YP_002402511.1 CDS yciN NC_011748.1 1472145 1472396 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029379, 7567469, 9868784; hypothetical protein complement(1472145..1472396) Escherichia coli 55989 7147675 YP_002402512.1 CDS EC55989_1431 NC_011748.1 1472441 1472653 D Evidence 6 : Doubtful CDS; hypothetical protein 1472441..1472653 Escherichia coli 55989 7148349 YP_002402513.1 CDS topA NC_011748.1 1472776 1475373 D catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity; DNA topoisomerase I 1472776..1475373 Escherichia coli 55989 7144596 YP_002402514.1 CDS cysB NC_011748.1 1475583 1476557 D LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation; transcriptional regulator CysB 1475583..1476557 Escherichia coli 55989 7147818 YP_002402515.1 CDS EC55989_1434 NC_011748.1 1476851 1477015 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1476851..1477015 Escherichia coli 55989 7145821 YP_002402516.1 CDS EC55989_1435 NC_011748.1 1476997 1477185 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1476997..1477185 Escherichia coli 55989 7144597 YP_002402517.1 CDS EC55989_1436 NC_011748.1 1477322 1477504 D Evidence 6 : Doubtful CDS; hypothetical protein 1477322..1477504 Escherichia coli 55989 7144598 YP_002402518.1 CDS acnA NC_011748.1 1477558 1480233 D Catalyzes the conversion of citrate to isocitrate; aconitate hydratase 1477558..1480233 Escherichia coli 55989 7144599 YP_002402519.1 CDS ribA NC_011748.1 1480297 1480887 R catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate; GTP cyclohydrolase II complement(1480297..1480887) Escherichia coli 55989 7145438 YP_002402520.1 CDS pgpB NC_011748.1 1481057 1481821 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033893, 92104964; Product type e : enzyme; phosphatidylglycerophosphatase B 1481057..1481821 Escherichia coli 55989 7147409 YP_002402521.1 CDS yciS NC_011748.1 1481970 1482278 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1481970..1482278 Escherichia coli 55989 7147155 YP_002402522.1 CDS yciM NC_011748.1 1482285 1483454 D Evidence 4 : Homologs of previously reported genes of unknown function; tetratricopeptide repeat protein 1482285..1483454 Escherichia coli 55989 7148351 YP_002402523.1 CDS pyrF NC_011748.1 1483647 1484384 D type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase; orotidine 5'-phosphate decarboxylase 1483647..1484384 Escherichia coli 55989 7148348 YP_002402524.1 CDS yciH NC_011748.1 1484384 1484710 D involved in start site selection during the initiation of translation; translation initiation factor Sui1 1484384..1484710 Escherichia coli 55989 7147321 YP_002402525.1 CDS osmB NC_011748.1 1484836 1485054 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 2644204; Product type lp : lipoprotein; lipoprotein complement(1484836..1485054) Escherichia coli 55989 7148345 YP_002402526.1 CDS deoT NC_011748.1 1485323 1486072 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16451192; Product type r : regulator; DNA-binding transcriptional repressor, DeoR family complement(1485323..1486072) Escherichia coli 55989 7147081 YP_002402527.1 CDS EC55989_1446 NC_011748.1 1486162 1486377 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1486162..1486377) Escherichia coli 55989 7145891 YP_002402528.1 CDS gmr NC_011748.1 1486482 1488467 R c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP; RNase II stability modulator complement(1486482..1488467) Escherichia coli 55989 7144600 YP_002402529.1 CDS rnb NC_011748.1 1488702 1490636 R Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction; exoribonuclease II complement(1488702..1490636) Escherichia coli 55989 7146345 YP_002402530.1 CDS yciW NC_011748.1 1490704 1491831 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; amidase complement(1490704..1491831) Escherichia coli 55989 7147444 YP_002402531.1 CDS fabI NC_011748.1 1491976 1492764 R Catalyzes a key regulatory step in fatty acid biosynthesis; enoyl-(acyl carrier protein) reductase complement(1491976..1492764) Escherichia coli 55989 7148354 YP_002402532.1 CDS ycjD NC_011748.1 1493134 1493487 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1493134..1493487) Escherichia coli 55989 7146052 YP_002402533.1 CDS sapF NC_011748.1 1493555 1494361 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580; Product type t : transporter; antimicrobial peptide transporter subunit ; ATP-binding component of ABC superfamily transporter complement(1493555..1494361) Escherichia coli 55989 7148355 YP_002402534.1 CDS sapD NC_011748.1 1494363 1495355 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 10720487, 9634580, 1987159; Product type t : transporter; antimicrobial peptide transporter subunit; ATP-binding component of ABC superfamily transporter complement(1494363..1495355) Escherichia coli 55989 7147605 YP_002402535.1 CDS sapC NC_011748.1 1495355 1496245 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide transporter subunit ; permease component of ABC superfamily transporter complement(1495355..1496245) Escherichia coli 55989 7147604 YP_002402536.1 CDS sapB NC_011748.1 1496232 1497197 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide transporter subunit ; permease component of ABC superfamily transporter complement(1496232..1497197) Escherichia coli 55989 7147603 YP_002402537.1 CDS sapA NC_011748.1 1497194 1498837 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2109018, 9634580; Product type t : transporter; antimicrobial peptide transporter subunit; periplasmic-binding component of ABC superfamily transporter complement(1497194..1498837) Escherichia coli 55989 7147602 YP_002402538.1 CDS ymjA NC_011748.1 1499149 1499394 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1499149..1499394) Escherichia coli 55989 7147601 YP_002402539.1 CDS puuP NC_011748.1 1499528 1500913 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15590624; Product type t : transporter; putrescine importer complement(1499528..1500913) Escherichia coli 55989 7149282 YP_002402540.1 CDS puuA NC_011748.1 1501216 1502634 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15590624; Product type e : enzyme; gamma-Glu-putrescine synthase complement(1501216..1502634) Escherichia coli 55989 7147313 YP_002402541.1 CDS puuD NC_011748.1 1502846 1503610 D catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate; gamma-glutamyl-gamma-aminobutyrate hydrolase 1502846..1503610 Escherichia coli 55989 7147308 YP_002402542.1 CDS puuR NC_011748.1 1503637 1504194 D regulates genes involved in putrescine degradation; DNA-binding transcriptional repressor PuuR 1503637..1504194 Escherichia coli 55989 7147311 YP_002402543.1 CDS puuC NC_011748.1 1504469 1505956 D catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation; gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase 1504469..1505956 Escherichia coli 55989 7147314 YP_002402544.1 CDS puuB NC_011748.1 1505958 1507238 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150200, 15590624; Product type e : enzyme; gamma-Glu-putrescine oxidase 1505958..1507238 Escherichia coli 55989 7147310 YP_002402545.1 CDS puuE NC_011748.1 1507276 1508541 D putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 1507276..1508541 Escherichia coli 55989 7147309 YP_002402546.1 CDS pspF NC_011748.1 1508661 1509638 R transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor; phage shock protein operon transcriptional activator complement(1508661..1509638) Escherichia coli 55989 7147312 YP_002402547.1 CDS pspA NC_011748.1 1509805 1510473 D involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF; phage shock protein PspA 1509805..1510473 Escherichia coli 55989 7147275 YP_002402548.1 CDS pspB NC_011748.1 1510527 1510751 D acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding; phage shock protein B 1510527..1510751 Escherichia coli 55989 7147270 YP_002402549.1 CDS pspC NC_011748.1 1510751 1511110 D with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock; DNA-binding transcriptional activator PspC 1510751..1511110 Escherichia coli 55989 7147271 YP_002402550.1 CDS pspD NC_011748.1 1511119 1511340 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295203, 97303082; Product type ph : phenotype; peripheral inner membrane phage-shock protein 1511119..1511340 Escherichia coli 55989 7147272 YP_002402551.1 CDS pspE NC_011748.1 1511415 1511729 D rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide; thiosulfate:cyanide sulfurtransferase 1511415..1511729 Escherichia coli 55989 7147273 YP_002402552.1 CDS ycjM NC_011748.1 1511941 1513620 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; glucosyltransferase 1511941..1513620 Escherichia coli 55989 7147274 YP_002402553.1 CDS ycjN NC_011748.1 1513634 1514926 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sugar transporter subunit: periplasmic-binding component of ABC superfamily transporter 1513634..1514926 Escherichia coli 55989 7148358 YP_002402554.1 CDS ycjO NC_011748.1 1514947 1515828 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sugar transporter subunit: permease component of ABC superfamily transporter 1514947..1515828 Escherichia coli 55989 7148359 YP_002402555.1 CDS ycjP NC_011748.1 1515815 1516657 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sugar transporter subunit: permease component of ABC superfamily transporter 1515815..1516657 Escherichia coli 55989 7148360 YP_002402556.1 CDS ycjQ NC_011748.1 1516688 1517740 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase, Zn-dependent and NAD(P)-binding 1516688..1517740 Escherichia coli 55989 7148361 YP_002402557.1 CDS ycjR NC_011748.1 1517758 1518546 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; isomerase/epimerase 1517758..1518546 Escherichia coli 55989 7148362 YP_002402558.1 CDS ycjT NC_011748.1 1519608 1521875 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; glycosyl hydrolase/phosphorylase 1519608..1521875 Escherichia coli 55989 7148365 YP_002402559.1 CDS ycjU NC_011748.1 1521872 1522531 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11972617; Product type pe : enzyme; glucose-1-phosphate phosphodismutase, beta-phosphoglucomutase 1521872..1522531 Escherichia coli 55989 7148366 YP_002402560.1 CDS ycjV NC_011748.1 1522545 1523627 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sugar transporter subunit: ATP-binding component of ABC superfamily transporter 1522545..1523627 Escherichia coli 55989 7148367 YP_002402561.1 CDS ompG NC_011748.1 1523672 1524577 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20464934, 89327119, 9721282; Product type t : transporter; outer membrane porin 1523672..1524577 Escherichia coli 55989 7148368 YP_002402562.1 CDS ycjW NC_011748.1 1524688 1525686 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(1524688..1525686) Escherichia coli 55989 7147068 YP_002402563.1 CDS ycjX NC_011748.1 1525841 1527238 D Evidence 4 : Homologs of previously reported genes of unknown function; nucleoside triphosphate hydrolase domain 1525841..1527238 Escherichia coli 55989 7148369 YP_002402564.1 CDS ycjF NC_011748.1 1527235 1528296 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 1527235..1528296 Escherichia coli 55989 7148370 YP_002402565.1 CDS tyrR NC_011748.1 1528444 1529985 D regulates genes involved in the biosynthesis and transport of aromatic amino acids; DNA-binding transcriptional regulator TyrR 1528444..1529985 Escherichia coli 55989 7148356 YP_002402566.1 CDS tpx NC_011748.1 1530029 1530535 R antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein; thiol peroxidase complement(1530029..1530535) Escherichia coli 55989 7147884 YP_002402567.1 CDS ycjG NC_011748.1 1530654 1531619 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11747447, 11747448, 7499381; Product type e : enzyme; L-Ala-D/L-Glu epimerase 1530654..1531619 Escherichia coli 55989 7147833 YP_002402568.1 CDS mpaA NC_011748.1 1531594 1532382 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12511517; Product type e : enzyme; murein peptide amidase A complement(1531594..1532382) Escherichia coli 55989 7148357 YP_002402569.1 CDS ycjY NC_011748.1 1532658 1533590 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase complement(1532658..1533590) Escherichia coli 55989 7149283 YP_002402570.1 CDS ycjZ NC_011748.1 1533716 1534615 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 17366475; Product type pr : regulator; nucleic acid-binding regulator 1533716..1534615 Escherichia coli 55989 7148371 YP_002402571.1 CDS mppA NC_011748.1 1534952 1536565 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438753, 9495761; Product type t : transporter; murein tripeptide (L-ala-gamma-D-glutamyl-meso-DAP) transporter subunit ; periplasmic-binding component of ABC superfamily 1534952..1536565 Escherichia coli 55989 7148372 YP_002402572.1 CDS ynaI NC_011748.1 1536616 1537647 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(1536616..1537647) Escherichia coli 55989 7146892 YP_002402573.1 CDS ynaJ NC_011748.1 1537891 1538148 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1537891..1538148 Escherichia coli 55989 7149284 YP_002402574.1 CDS uspE NC_011748.1 1538198 1539148 R with UspC and UspD is involved in resistance to UV irradiation; universal stress protein UspE complement(1538198..1539148) Escherichia coli 55989 7149285 YP_002402575.1 CDS fnr NC_011748.1 1539300 1540052 R Global transcription factor that controls the expression of over 100 target genes in response to anoxia; fumarate/nitrate reduction transcriptional regulator complement(1539300..1540052) Escherichia coli 55989 7147929 YP_002402576.1 CDS ogt NC_011748.1 1540247 1540762 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88067749, 91161525, 94252990, 98125595, 1520330; Product type e : enzyme; O-6-alkylguanine-DNA:cysteine-protein methyltransferase complement(1540247..1540762) Escherichia coli 55989 7146165 YP_002402577.1 CDS abgT NC_011748.1 1540773 1542299 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9829935, 2825131, 7567469; Product type t : transporter; aminobenzoyl-glutamate transporter complement(1540773..1542299) Escherichia coli 55989 7147064 YP_002402578.1 CDS EC55989_1501 NC_011748.1 1542229 1542423 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1542229..1542423) Escherichia coli 55989 7145426 YP_002402579.1 CDS abgB NC_011748.1 1542336 1543781 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9829935; Product type pe : enzyme; peptidase, aminobenzoyl-glutamate utilization protein complement(1542336..1543781) Escherichia coli 55989 7144601 YP_002402580.1 CDS abgA NC_011748.1 1543781 1545091 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9829935; Product type pe : enzyme; peptidase, para-aminobenzoyl-glutamate utilization protein complement(1543781..1545091) Escherichia coli 55989 7145424 YP_002402581.1 CDS abgR NC_011748.1 1545267 1546175 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9829935; Product type r : regulator; DNA-binding transcriptional regulator 1545267..1546175 Escherichia coli 55989 7145423 YP_002402582.1 CDS ydaL NC_011748.1 1546505 1547068 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1546505..1547068 Escherichia coli 55989 7146633 YP_002402583.1 CDS ydaM NC_011748.1 1547089 1548321 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16045609; Product type pe : enzyme; diguanylate cyclase, GG[D/E]EF domain signalling protein complement(1547089..1548321) Escherichia coli 55989 7148373 YP_002402584.1 CDS zntB NC_011748.1 1548576 1549559 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; zinc transporter 1548576..1549559 Escherichia coli 55989 7148374 YP_002402585.1 CDS EC55989_1508 NC_011748.1 1549834 1550007 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1549834..1550007 Escherichia coli 55989 7148375 YP_002402586.1 CDS dbpA NC_011748.1 1550037 1551410 D exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA; ATP-dependent RNA helicase DbpA 1550037..1551410 Escherichia coli 55989 7145649 YP_002402587.1 CDS ydaO NC_011748.1 1551539 1552474 R TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs; C32 tRNA thiolase complement(1551539..1552474) Escherichia coli 55989 7145854 YP_002402588.1 CDS uspF NC_011748.1 1552650 1553084 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 12381839, 11849540, 9298646; Product type f : factor; stress-induced protein, ATP-binding protein complement(1552650..1553084) Escherichia coli 55989 7148376 YP_002402589.1 CDS ompN NC_011748.1 1553225 1554358 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642192; Product type t : transporter; outer membrane pore protein N, non-specific complement(1553225..1554358) Escherichia coli 55989 7147930 YP_002402590.1 CDS ydbK NC_011748.1 1554725 1558249 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9025293; Product type pe : enzyme; 2-oxoacid-flavodoxin fused oxidoreductase:conserved protein; 4Fe-4S cluster binding protein complement(1554725..1558249) Escherichia coli 55989 7146855 YP_002402591.1 CDS ydbJ NC_011748.1 1558523 1558789 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1558523..1558789 Escherichia coli 55989 7148381 YP_002402592.1 CDS hslJ NC_011748.1 1558786 1559208 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12892888, 8349564, 9025293; Product type f : factor; heat-inducible protein complement(1558786..1559208) Escherichia coli 55989 7148380 YP_002402593.1 CDS ldhA NC_011748.1 1559319 1560308 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4297266, 89123040, 90198524, 8349564, 9025293; Product type e : enzyme; fermentative D-lactate dehydrogenase, NAD-dependent complement(1559319..1560308) Escherichia coli 55989 7146467 YP_002402594.1 CDS ydbH NC_011748.1 1560516 1563155 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1560516..1563155 Escherichia coli 55989 7146682 YP_002402595.1 CDS ynbE NC_011748.1 1563152 1563337 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; lipoprotein 1563152..1563337 Escherichia coli 55989 7148379 YP_002402596.1 CDS ydbL NC_011748.1 1563345 1563671 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1563345..1563671 Escherichia coli 55989 7149290 YP_002402597.1 CDS feaR NC_011748.1 1563843 1564748 R activator of genes involved in phenylacetic acid catabolism; DNA-binding transcriptional activator FeaR complement(1563843..1564748) Escherichia coli 55989 7148382 YP_002402598.1 CDS feaB NC_011748.1 1564984 1566483 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96213037, 97263463, 9043126; Product type e : enzyme; phenylacetaldehyde dehydrogenase 1564984..1566483 Escherichia coli 55989 7146078 YP_002402599.1 CDS tynA NC_011748.1 1566541 1568814 R catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine; tyramine oxidase complement(1566541..1568814) Escherichia coli 55989 7146077 YP_002402600.1 CDS maoC NC_011748.1 1569062 1571107 R catalyzes the ring cleavage reaction in phenylacetate degradation and the formation of 3-hydroxyacyl-CoA from crotonyl-CoA; bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase complement(1569062..1571107) Escherichia coli 55989 7147880 YP_002402601.1 CDS paaA NC_011748.1 1571392 1572321 D with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; phenylacetate-CoA oxygenase subunit PaaA 1571392..1572321 Escherichia coli 55989 7146785 YP_002402602.1 CDS paaB NC_011748.1 1572333 1572620 D with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation; phenylacetate-CoA oxygenase subunit PaaB 1572333..1572620 Escherichia coli 55989 7147093 YP_002402603.1 CDS paaC NC_011748.1 1572629 1573375 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : enzyme; multicomponent oxygenase/reductase subunit for phenylacetic acid degradation 1572629..1573375 Escherichia coli 55989 7147094 YP_002402604.1 CDS paaD NC_011748.1 1573390 1573887 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : enzyme; multicomponent oxygenase/reductase subunit for phenylacetic acid degradation 1573390..1573887 Escherichia coli 55989 7147095 YP_002402605.1 CDS paaJ NC_011748.1 1573895 1574965 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 17259607, 11260461, 12846838, 9748275; Product type e : enzyme; subunit of the phenylacetly-CoA oxygenase/reductase 1573895..1574965 Escherichia coli 55989 7147096 YP_002402606.1 CDS paaF NC_011748.1 1574962 1575729 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 9748275, 10766858; Product type e : enzyme; enoyl-CoA hydratase-isomerase 1574962..1575729 Escherichia coli 55989 7147102 YP_002402607.1 CDS paaG NC_011748.1 1575729 1576517 D Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA; enoyl-CoA hydratase 1575729..1576517 Escherichia coli 55989 7147098 YP_002402608.1 CDS paaH NC_011748.1 1576519 1577946 D converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation; 3-hydroxyacyl-CoA dehydrogenase 1576519..1577946 Escherichia coli 55989 7147099 YP_002402609.1 CDS paaI NC_011748.1 1577936 1578358 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16464851, 12846838, 9748275; Product type e : enzyme; phenylacetate pathway hotdog-fold thioesterase 1577936..1578358 Escherichia coli 55989 7147100 YP_002402610.1 CDS paaE NC_011748.1 1578358 1579563 D catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA; beta-ketoadipyl CoA thiolase 1578358..1579563 Escherichia coli 55989 7147101 YP_002402611.1 CDS paaK NC_011748.1 1579590 1580903 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 9748275, 10766858; Product type e : enzyme; phenylacetyl-CoA ligase 1579590..1580903 Escherichia coli 55989 7147097 YP_002402612.1 CDS paaX NC_011748.1 1581004 1581954 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12846838, 20229831, 9748275; Product type r : regulator; DNA-binding transcriptional repressor of phenylacetic acid degradation, aryl-CoA responsive 1581004..1581954 Escherichia coli 55989 7147103 YP_002402613.1 CDS paaY NC_011748.1 1581936 1582526 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12846838, 9748275; Product type pe : enzyme; hexapeptide repeat acetyltransferase 1581936..1582526 Escherichia coli 55989 7147104 YP_002402614.1 CDS ydbC NC_011748.1 1582756 1583616 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase 1582756..1583616 Escherichia coli 55989 7147105 YP_002402615.1 CDS ydbD NC_011748.1 1583680 1585986 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1583680..1585986 Escherichia coli 55989 7148377 YP_002402616.1 CDS ynbA NC_011748.1 1586157 1586762 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1586157..1586762 Escherichia coli 55989 7148378 YP_002402617.1 CDS ynbB NC_011748.1 1586762 1587658 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane associated CTP-phosphosubstrate transferase 1586762..1587658 Escherichia coli 55989 7149286 YP_002402618.1 CDS ynbC NC_011748.1 1587674 1589431 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase 1587674..1589431 Escherichia coli 55989 7149287 YP_002402619.1 CDS ynbD NC_011748.1 1589445 1590737 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane associated phosphatase 1589445..1590737 Escherichia coli 55989 7149288 YP_002402620.1 CDS azoR NC_011748.1 1590788 1591393 R FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds; azoreductase complement(1590788..1591393) Escherichia coli 55989 7149289 YP_002402621.1 CDS hrpA NC_011748.1 1591651 1595496 D involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain; ATP-dependent RNA helicase HrpA 1591651..1595496 Escherichia coli 55989 7145590 YP_002402622.1 CDS ydcF NC_011748.1 1595768 1596568 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1595768..1596568 Escherichia coli 55989 7146459 YP_002402623.1 CDS aldA NC_011748.1 1596765 1598204 D NAD-linked; aldehyde dehydrogenase 1596765..1598204 Escherichia coli 55989 7148385 YP_002402624.1 CDS gapC NC_011748.1 1598246 1599247 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9622357, 9019141, 1917845, 3780374; Product type e : enzyme; glyceraldehyde-3-phosphate dehydrogenase complement(1598246..1599247) Escherichia coli 55989 7145479 YP_002402625.1 CDS cybB NC_011748.1 1599436 1599966 D B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm; cytochrome b561 1599436..1599966 Escherichia coli 55989 7146257 YP_002402626.1 CDS ydcA NC_011748.1 1600211 1600384 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1600211..1600384 Escherichia coli 55989 7147577 YP_002402627.1 CDS mokB NC_011748.1 1600496 1600663 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type r : regulator; regulatory peptide complement(1600496..1600663) Escherichia coli 55989 7148383 YP_002402628.1 CDS trg NC_011748.1 1601004 1602644 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90008892, 92390356, 93259131, 6374654; Product type r : regulator; methyl-accepting chemotaxis protein III, ribose and galactose sensor receptor 1601004..1602644 Escherichia coli 55989 7147676 YP_002402629.1 CDS ydcI NC_011748.1 1602682 1603605 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(1602682..1603605) Escherichia coli 55989 7147840 YP_002402630.1 CDS ydcJ NC_011748.1 1603822 1605165 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1603822..1605165 Escherichia coli 55989 7148387 YP_002402631.1 CDS mdoD NC_011748.1 1605420 1607045 D involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans; glucan biosynthesis protein D 1605420..1607045 Escherichia coli 55989 7148388 YP_002402632.1 CDS EC55989_1556 NC_011748.1 1606966 1607169 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1606966..1607169) Escherichia coli 55989 7146799 YP_002402633.1 CDS ydcH NC_011748.1 1607185 1607409 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1607185..1607409 Escherichia coli 55989 7144603 YP_002402634.1 CDS rimL NC_011748.1 1607457 1608008 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89364711; Product type e : enzyme; ribosomal-protein-L7/L12-serine acetyltransferase 1607457..1608008 Escherichia coli 55989 7148386 YP_002402635.1 CDS ydcK NC_011748.1 1608003 1608983 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein complement(1608003..1608983) Escherichia coli 55989 7147421 YP_002402636.1 CDS tehA NC_011748.1 1609107 1610099 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94222856, 2060788; Product type t : transporter; potassium-tellurite ethidium and proflavin transporter 1609107..1610099 Escherichia coli 55989 7148389 YP_002402637.1 CDS tehB NC_011748.1 1610096 1610689 D with TehA confers resistance to tellurite; tellurite resistance protein TehB 1610096..1610689 Escherichia coli 55989 7147773 YP_002402638.1 CDS ydcL NC_011748.1 1610992 1611660 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; lipoprotein 1610992..1611660 Escherichia coli 55989 7147774 YP_002402639.1 CDS EC55989_1563 NC_011748.1 1611678 1611845 R Evidence 7 : Gene remnant; Product type pe : enzyme; transposase ORF A (fragment), IS605 family complement(1611678..1611845) Escherichia coli 55989 7148390 YP_002402640.1 CDS EC55989_1564 NC_011748.1 1611957 1612112 R Evidence 7 : Gene remnant; Product type pe : enzyme; transposase ORF A (fragment), IS605 family complement(1611957..1612112) Escherichia coli 55989 7144604 YP_002402641.1 CDS ydcM NC_011748.1 1612187 1613395 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase 1612187..1613395 Escherichia coli 55989 7144605 YP_002402642.1 CDS ydcO NC_011748.1 1613435 1614610 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1885518; Product type pt : transporter; benzoate transporter complement(1613435..1614610) Escherichia coli 55989 7148391 YP_002402643.1 CDS ydcN NC_011748.1 1614702 1615238 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1614702..1615238 Escherichia coli 55989 7148395 YP_002402644.1 CDS ydcP NC_011748.1 1615311 1617272 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; peptidase 1615311..1617272 Escherichia coli 55989 7148394 YP_002402645.1 CDS yncJ NC_011748.1 1617364 1617594 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1617364..1617594) Escherichia coli 55989 7148396 YP_002402646.1 CDS ydcQ NC_011748.1 1617995 1618432 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1617995..1618432 Escherichia coli 55989 7149298 YP_002402647.1 CDS ydcR NC_011748.1 1618511 1619917 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15223311; Product type pr : regulator; DNA-binding transcriptional regulator fused with a domain with PLP-binding motif 1618511..1619917 Escherichia coli 55989 7148397 YP_002402648.1 CDS ydcS NC_011748.1 1620162 1621307 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11683869; Product type pt : transporter; spermidine/putrescine transporter subunit ; periplasmic-binding component of ABC superfamily transporter 1620162..1621307 Escherichia coli 55989 7148398 YP_002402649.1 CDS ydcT NC_011748.1 1621325 1622338 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; spermidine/putrescine transporter subunit ; ATP-binding component of ABC superfamily tranporter 1621325..1622338 Escherichia coli 55989 7148399 YP_002402650.1 CDS ydcU NC_011748.1 1622339 1623280 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; spermidine/putrescine transporter subunit ; permease of ABC superfamily transporter 1622339..1623280 Escherichia coli 55989 7148400 YP_002402651.1 CDS ydcV NC_011748.1 1623270 1624064 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; spermidine/putrescine transporter subunit; permease component of ABC superfamily 1623270..1624064 Escherichia coli 55989 7148401 YP_002402652.1 CDS ydcW NC_011748.1 1624086 1625510 D catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation; gamma-aminobutyraldehyde dehydrogenase 1624086..1625510 Escherichia coli 55989 7148402 YP_002402653.1 CDS EC55989_1577 NC_011748.1 1625720 1626529 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8257133, 11841212, 12771141; Product type pe : enzyme; acetyltransferase 1625720..1626529 Escherichia coli 55989 7148403 YP_002402654.1 CDS ydcX NC_011748.1 1627146 1627394 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1627146..1627394 Escherichia coli 55989 7144606 YP_002402655.1 CDS ydcY NC_011748.1 1627480 1627713 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1627480..1627713 Escherichia coli 55989 7148404 YP_002402656.1 CDS ydcZ NC_011748.1 1627714 1628163 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(1627714..1628163) Escherichia coli 55989 7148405 YP_002402657.1 CDS yncA NC_011748.1 1628160 1628912 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acyl-CoA N-acyltransferase complement(1628160..1628912) Escherichia coli 55989 7148406 YP_002402658.1 CDS yncB NC_011748.1 1628859 1629896 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; conserved oxidoreductase, Zn-dependent and NAD(P)-binding 1628859..1629896 Escherichia coli 55989 7149291 YP_002402659.1 CDS yncC NC_011748.1 1630094 1630759 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11004173; Product type pr : regulator; DNA-binding transcriptional regulator 1630094..1630759 Escherichia coli 55989 7149292 YP_002402660.1 CDS yncD NC_011748.1 1630795 1632897 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type prc : receptor; iron outer membrane receptor complement(1630795..1632897) Escherichia coli 55989 7149293 YP_002402661.1 CDS yncE NC_011748.1 1633139 1634200 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1633139..1634200 Escherichia coli 55989 7149294 YP_002402662.1 CDS ansP NC_011748.1 1634313 1635812 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005443; Product type t : transporter; L-asparagine transporter complement(1634313..1635812) Escherichia coli 55989 7149295 YP_002402663.1 CDS yncG NC_011748.1 1636079 1636696 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; glutathione S-transferase-like protein 1636079..1636696 Escherichia coli 55989 7145504 YP_002402664.1 CDS EC55989_1588 NC_011748.1 1637768 1639912 D Evidence 4 : Homologs of previously reported genes of unknown function; VgrG protein, Encoded within repeats that are hotspots for chromosomal duplication formation; Function of protein is unknown 1637768..1639912 Escherichia coli 55989 7149296 YP_002402665.1 CDS rhsD NC_011748.1 1639980 1644221 D Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 1766878, 2403547, 2644231, 7934896; Product type h : extrachromosomal origin; rhsD element protein 1639980..1644221 Escherichia coli 55989 7144607 YP_002402666.1 CDS EC55989_1590 NC_011748.1 1644221 1644682 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9696756; hypothetical protein 1644221..1644682 Escherichia coli 55989 7147404 YP_002402667.1 CDS EC55989_1592 NC_011748.1 1645701 1645994 D 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown; 4-oxalocrotonate tautomerase 1645701..1645994 Escherichia coli 55989 7148983 YP_002402668.1 CDS yddH NC_011748.1 1645998 1646567 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1645998..1646567) Escherichia coli 55989 7144609 YP_002402669.1 CDS nhoA NC_011748.1 1646740 1647585 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20267568; Product type e : enzyme; N-hydroxyarylamine O-acetyltransferase 1646740..1647585 Escherichia coli 55989 7148411 YP_002402670.1 CDS yddE NC_011748.1 1647681 1648574 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14611652, 15103639, 2233673; hypothetical protein complement(1647681..1648574) Escherichia coli 55989 7146994 YP_002402671.1 CDS narV NC_011748.1 1648653 1649333 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 (NRZ), gamma subunit complement(1648653..1649333) Escherichia coli 55989 7148409 YP_002402672.1 CDS narW NC_011748.1 1649330 1650025 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410, 92186712; Product type f : factor; nitrate reductase 2 (NRZ), delta subunit (assembly subunit) complement(1649330..1650025) Escherichia coli 55989 7146976 YP_002402673.1 CDS narY NC_011748.1 1650025 1651569 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type c : carrier; nitrate reductase 2 (NRZ), beta subunit complement(1650025..1651569) Escherichia coli 55989 7146977 YP_002402674.1 CDS narZ NC_011748.1 1651566 1655306 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91042410; Product type e : enzyme; nitrate reductase 2 (NRZ), alpha subunit complement(1651566..1655306) Escherichia coli 55989 7146979 YP_002402675.1 CDS narU NC_011748.1 1655388 1656776 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95266795, 2233673; Product type t : transporter; nitrate/nitrite transporter complement(1655388..1656776) Escherichia coli 55989 7146980 YP_002402676.1 CDS EC55989_1602 NC_011748.1 1657100 1658431 R Evidence 4 : Homologs of previously reported genes of unknown function; glycoprotein with ribonuclease inhibitor domain (yddK) (modular protein) complement(1657100..1658431) Escherichia coli 55989 7146975 YP_002402677.1 CDS yddL NC_011748.1 1658455 1658745 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7926834; Product type m : membrane component; outer membrane porin complement(1658455..1658745) Escherichia coli 55989 7144610 YP_002402678.1 CDS yddG NC_011748.1 1659004 1659828 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 12410826; Product type t : transporter; hypothetical protein complement(1659004..1659828) Escherichia coli 55989 7148412 YP_002402679.1 CDS fdnG NC_011748.1 1660117 1663164 D Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-N subunit alpha, nitrate-inducible 1660117..1663164 Escherichia coli 55989 7148410 YP_002402680.1 CDS fdnH NC_011748.1 1663177 1664061 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76005553, 90375017, 92332427, 11884747, 1834669; Product type c : carrier; formate dehydrogenase-N, Fe-S (beta) subunit, nitrate-inducible 1663177..1664061 Escherichia coli 55989 7146069 YP_002402681.1 CDS fdnI NC_011748.1 1664054 1664707 D nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase; formate dehydrogenase-N subunit gamma 1664054..1664707 Escherichia coli 55989 7146070 YP_002402682.1 CDS yddM NC_011748.1 1664758 1665120 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(1664758..1665120) Escherichia coli 55989 7146071 YP_002402683.1 CDS adhP NC_011748.1 1665189 1666199 R similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs; alcohol dehydrogenase complement(1665189..1666199) Escherichia coli 55989 7148413 YP_002402684.1 CDS sfcA NC_011748.1 1666333 1668030 R malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate; malate dehydrogenase complement(1666333..1668030) Escherichia coli 55989 7145456 YP_002402685.1 CDS bdm NC_011748.1 1668426 1668641 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10498711, 13129944; Product type f : factor; biofilm-dependent modulation protein complement(1668426..1668641) Escherichia coli 55989 7147639 YP_002402686.1 CDS osmC NC_011748.1 1668987 1669418 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14512736, 91350191, 9298646; Product type m : membrane component; osmotically inducible, stress-inducible membrane protein 1668987..1669418 Escherichia coli 55989 7145609 YP_002402687.1 CDS ddpF NC_011748.1 1669474 1670400 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala transporter subunit ; ATP-binding component of ABC superfamily complement(1669474..1670400) Escherichia coli 55989 7147082 YP_002402688.1 CDS ddpD NC_011748.1 1670393 1671379 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala transporter subunit ; ATP-binding component of ABC superfamily complement(1670393..1671379) Escherichia coli 55989 7145873 YP_002402689.1 CDS ddpC NC_011748.1 1671376 1672272 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; ATP-dependent peptide transporter membrane subunit complement(1671376..1672272) Escherichia coli 55989 7145872 YP_002402690.1 CDS ddpB NC_011748.1 1672269 1673291 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-ala transporter subunit ; membrane component of ABC superfamily complement(1672269..1673291) Escherichia coli 55989 7145871 YP_002402691.1 CDS ddpA NC_011748.1 1673293 1674843 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99432174; Product type t : transporter; D-ala-D-a la transporter subunit ; periplasmic-binding component of ABC superfamily complement(1673293..1674843) Escherichia coli 55989 7145870 YP_002402692.1 CDS ddpX NC_011748.1 1674857 1675438 R catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis; D-alanyl-D-alanine dipeptidase complement(1674857..1675438) Escherichia coli 55989 7145869 YP_002402693.1 CDS dos NC_011748.1 1675696 1678095 R heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate; cAMP phosphodiesterase complement(1675696..1678095) Escherichia coli 55989 7145874 YP_002402694.1 CDS yddV NC_011748.1 1678120 1679502 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16497924, 15142243; Product type pe : enzyme; diguanylate cyclase YddV complement(1678120..1679502) Escherichia coli 55989 7145943 YP_002402695.1 CDS yddW NC_011748.1 1679874 1681193 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10960106; Product type lp : lipoprotein; lipoprotein complement(1679874..1681193) Escherichia coli 55989 7148414 YP_002402696.1 CDS gadC NC_011748.1 1681324 1682859 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15795232, 15489450; Product type t : transporter; glutamate:gamma-aminobutyric acid antiporter complement(1681324..1682859) Escherichia coli 55989 7148415 YP_002402697.1 CDS gadB NC_011748.1 1683015 1684415 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12912902, 92155241, 92394884, 99406302, 8455549; Product type e : enzyme; glutamate decarboxylase complement(1683015..1684415) Escherichia coli 55989 7146242 YP_002402698.1 CDS pqqL NC_011748.1 1684777 1687572 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1659611, 11514505; Product type pe : enzyme; membrane-associated peptidase complement(1684777..1687572) Escherichia coli 55989 7146241 YP_002402699.1 CDS yddB NC_011748.1 1687617 1689989 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; porin protein complement(1687617..1689989) Escherichia coli 55989 7147238 YP_002402700.1 CDS yddA NC_011748.1 1690027 1691712 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; multidrug transporter fused subunits of ABC superfamily transporter: permease component; ATP-binding component complement(1690027..1691712) Escherichia coli 55989 7148408 YP_002402701.1 CDS ydeM NC_011748.1 1692003 1693160 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pr : regulator; hypothetical protein complement(1692003..1693160) Escherichia coli 55989 7148407 YP_002402702.1 CDS ydeN NC_011748.1 1693212 1694894 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; sulfatase complement(1693212..1694894) Escherichia coli 55989 7148421 YP_002402703.1 CDS ydeO NC_011748.1 1695296 1696057 R regulates the cellular response to acid resistance; transcriptional regulator YdeO complement(1695296..1696057) Escherichia coli 55989 7148422 YP_002402704.1 CDS EC55989_1632 NC_011748.1 1696132 1696329 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1696132..1696329) Escherichia coli 55989 7148423 YP_002402705.1 CDS ydeP NC_011748.1 1696577 1698856 R in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family; oxidoreductase complement(1696577..1698856) Escherichia coli 55989 7144611 YP_002402706.1 CDS ydeQ NC_011748.1 1699190 1700104 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein complement(1699190..1700104) Escherichia coli 55989 7148424 YP_002402707.1 CDS ydeR NC_011748.1 1700163 1700666 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein complement(1700163..1700666) Escherichia coli 55989 7148425 YP_002402708.1 CDS ydeS NC_011748.1 1700679 1701209 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein complement(1700679..1701209) Escherichia coli 55989 7148426 YP_002402709.1 CDS EC55989_1637 NC_011748.1 1701223 1703874 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; fimbrial outer membrane usher protein complement(1701223..1703874) Escherichia coli 55989 7148427 YP_002402710.1 CDS EC55989_1638 NC_011748.1 1703916 1704635 R Evidence 2b : Function of strongly homologous gene; Product type f : factor; Periplasmic chaperone precursor complement(1703916..1704635) Escherichia coli 55989 7144612 YP_002402711.1 CDS EC55989_1639 NC_011748.1 1704987 1705598 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; major fimbrial subunit FmlA complement(1704987..1705598) Escherichia coli 55989 7144613 YP_002402712.1 CDS yneL NC_011748.1 1706006 1706185 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator complement(1706006..1706185) Escherichia coli 55989 7144614 YP_002402713.1 CDS hipA NC_011748.1 1706503 1707825 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358364, 94292428, 15576765; Product type r : regulator; regulator with hipB complement(1706503..1707825) Escherichia coli 55989 7149309 YP_002402714.1 CDS hipB NC_011748.1 1707825 1708091 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358364, 94292428, 15576765, 8021189; Product type r : regulator; DNA-binding transcriptional regulator HipB complement(1707825..1708091) Escherichia coli 55989 7146428 YP_002402715.1 CDS EC55989_1643 NC_011748.1 1708300 1713720 R Evidence 4 : Homologs of previously reported genes of unknown function; lipoprotein/autotransporter domain-containing protein complement(1708300..1713720) Escherichia coli 55989 7146429 YP_002402716.1 CDS lsrK NC_011748.1 1714251 1715843 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15601708, 14622426; Product type e : enzyme; autoinducer-2 (AI-2) kinase complement(1714251..1715843) Escherichia coli 55989 7144615 YP_002402717.1 CDS lsrR NC_011748.1 1715922 1716875 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16321939, 15601708, 14622426; Product type r : regulator; DNA-binding transcriptional regulator complement(1715922..1716875) Escherichia coli 55989 7146751 YP_002402718.1 CDS ego NC_011748.1 1717124 1718659 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12657059, 11722742; Product type t : transporter; fused AI2 transporter subunits of ABC superfamily: ATP-binding components 1717124..1718659 Escherichia coli 55989 7146752 YP_002402719.1 CDS lsrC NC_011748.1 1718653 1719681 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter; AI2 transporter ; membrane component of ABC superfamily 1718653..1719681 Escherichia coli 55989 7145982 YP_002402720.1 CDS lsrD NC_011748.1 1719681 1720673 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter; AI2 transporter ; membrane component of ABC superfamily 1719681..1720673 Escherichia coli 55989 7146747 YP_002402721.1 CDS lsrB NC_011748.1 1720685 1721707 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11722742; Product type t : transporter; AI2 transporter ; periplasmic-binding component of ABC superfamily 1720685..1721707 Escherichia coli 55989 7146748 YP_002402722.1 CDS lsrF NC_011748.1 1721734 1722609 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; aldolase 1721734..1722609 Escherichia coli 55989 7146746 YP_002402723.1 CDS lsrG NC_011748.1 1722633 1722923 D Evidence 4 : Homologs of previously reported genes of unknown function; autoinducer-2 (AI-2) modifying protein LsrG 1722633..1722923 Escherichia coli 55989 7146749 YP_002402724.1 CDS tam NC_011748.1 1722980 1723738 D catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate; trans-aconitate 2-methyltransferase 1722980..1723738 Escherichia coli 55989 7146750 YP_002402725.1 CDS yneE NC_011748.1 1723742 1724656 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(1723742..1724656) Escherichia coli 55989 7147749 YP_002402726.1 CDS uxaB NC_011748.1 1724863 1726314 R catalyzes the formation of D-tagaturonate from D-altronate; altronate oxidoreductase complement(1724863..1726314) Escherichia coli 55989 7149300 YP_002402727.1 CDS yneF NC_011748.1 1726541 1727959 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane-associated diguanylate cyclase (GGDEF domain) complement(1726541..1727959) Escherichia coli 55989 7147939 YP_002402728.1 CDS yneG NC_011748.1 1728098 1728457 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1728098..1728457) Escherichia coli 55989 7149301 YP_002402729.1 CDS yneH NC_011748.1 1728457 1729383 R catalyzes the formation of glutamate from glutamine; glutaminase complement(1728457..1729383) Escherichia coli 55989 7149302 YP_002402730.1 CDS yneI NC_011748.1 1729447 1730835 R in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase; succinate semialdehyde dehydrogenase complement(1729447..1730835) Escherichia coli 55989 7149303 YP_002402731.1 CDS yneJ NC_011748.1 1730936 1731817 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1730936..1731817 Escherichia coli 55989 7149304 YP_002402732.1 CDS ydeA NC_011748.1 1733158 1734348 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10094697, 99369894, 8383113, 10438792; Product type t : transporter; sugar efflux transporter 1733158..1734348 Escherichia coli 55989 7149308 YP_002402733.1 CDS marC NC_011748.1 1734373 1735038 R protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function; multiple drug resistance protein MarC complement(1734373..1735038) Escherichia coli 55989 7148416 YP_002402734.1 CDS marR NC_011748.1 1735250 1735684 D Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes; DNA-binding transcriptional repressor MarR 1735250..1735684 Escherichia coli 55989 7146789 YP_002402735.1 CDS marA NC_011748.1 1735704 1736087 D transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF; DNA-binding transcriptional activator MarA 1735704..1736087 Escherichia coli 55989 7146790 YP_002402736.1 CDS marB NC_011748.1 1736119 1736337 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8383113; hypothetical protein 1736119..1736337 Escherichia coli 55989 7146787 YP_002402737.1 CDS celA NC_011748.1 1736394 1737839 R converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism; 6-phospho-beta-glucosidase complement(1736394..1737839) Escherichia coli 55989 7146788 YP_002402738.1 CDS EC55989_1669 NC_011748.1 1737858 1739531 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; carbohydrate-specific outer membrane porin complement(1737858..1739531) Escherichia coli 55989 7144616 YP_002402739.1 CDS EC55989_1670 NC_011748.1 1739587 1739901 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; PTS system lactose/cellobiose-specific transporter subunit IIA complement(1739587..1739901) Escherichia coli 55989 7144617 YP_002402740.1 CDS EC55989_1671 NC_011748.1 1739926 1741287 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; PTS system transporter subunit IIC complement(1739926..1741287) Escherichia coli 55989 7144618 YP_002402741.1 CDS EC55989_1672 NC_011748.1 1741363 1741674 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; cellobiose-specific phosphotransferase enzyme IIB component complement(1741363..1741674) Escherichia coli 55989 7144619 YP_002402742.1 CDS EC55989_1673 NC_011748.1 1741873 1742571 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator HTH family 1741873..1742571 Escherichia coli 55989 7144620 YP_002402743.1 CDS eamA NC_011748.1 1742616 1743515 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20305052; Product type t : transporter; O-acetylserine/cysteine export protein complement(1742616..1743515) Escherichia coli 55989 7144621 YP_002402744.1 CDS ydeE NC_011748.1 1743710 1744897 D YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters; MFS-type transporter YdeE 1743710..1744897 Escherichia coli 55989 7145966 YP_002402745.1 CDS ydeH NC_011748.1 1745339 1746229 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1745339..1746229) Escherichia coli 55989 7148417 YP_002402746.1 CDS ydeI NC_011748.1 1746484 1746876 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1746484..1746876) Escherichia coli 55989 7148418 YP_002402747.1 CDS ydeJ NC_011748.1 1747152 1747670 D Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A 1747152..1747670 Escherichia coli 55989 7148419 YP_002402748.1 CDS dcp NC_011748.1 1747715 1749760 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 216006, 8226676; Product type e : enzyme; dipeptidyl carboxypeptidase II complement(1747715..1749760) Escherichia coli 55989 7148420 YP_002402749.1 CDS ydfG NC_011748.1 1749897 1750643 D NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine; 3-hydroxy acid dehydrogenase 1749897..1750643 Escherichia coli 55989 7145857 YP_002402750.1 CDS ydfH NC_011748.1 1750732 1751418 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1750732..1751418 Escherichia coli 55989 7148434 YP_002402751.1 CDS ydfZ NC_011748.1 1751596 1751799 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12084818; Product type pc : carrier; selenium carrying protein 1751596..1751799 Escherichia coli 55989 7148435 YP_002402752.1 CDS ydfI NC_011748.1 1751835 1753295 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; mannonate dehydrogenase complement(1751835..1753295) Escherichia coli 55989 7148445 YP_002402753.1 CDS ydfJ NC_011748.1 1753384 1754667 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter complement(1753384..1754667) Escherichia coli 55989 7148436 YP_002402754.1 CDS yciG NC_011748.1 1755403 1755585 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1755403..1755585 Escherichia coli 55989 7148437 YP_002402755.1 CDS yciF NC_011748.1 1755658 1756164 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3058546, 8455549; hypothetical protein 1755658..1756164 Escherichia coli 55989 7148344 YP_002402756.1 CDS yciE NC_011748.1 1756201 1756707 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15388941, 3058546, 8455549; hypothetical protein 1756201..1756707 Escherichia coli 55989 7148342 YP_002402757.1 CDS EC55989_1689 NC_011748.1 1756726 1757616 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; Manganese Catalase of prophage 1756726..1757616 Escherichia coli 55989 7148340 YP_002402758.1 CDS tfaQ NC_011748.1 1757736 1758317 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; tail fiber chaperone; Qin prophage complement(1757736..1758317) Escherichia coli 55989 7144622 YP_002402759.1 CDS EC55989_1691 NC_011748.1 1758317 1761280 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber protein complement(1758317..1761280) Escherichia coli 55989 7147779 YP_002402760.1 CDS EC55989_1692 NC_011748.1 1761345 1761944 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; Lom-like outer membrane protein of phage origin complement(1761345..1761944) Escherichia coli 55989 7144623 YP_002402761.1 CDS EC55989_1693 NC_011748.1 1762014 1765427 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Host specificity protein J complement(1762014..1765427) Escherichia coli 55989 7144624 YP_002402762.1 CDS EC55989_1694 NC_011748.1 1765488 1766135 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail assembly protein I from prophage complement(1765488..1766135) Escherichia coli 55989 7144625 YP_002402763.1 CDS EC55989_1695 NC_011748.1 1766033 1766776 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber component K of prophage complement(1766033..1766776) Escherichia coli 55989 7144626 YP_002402764.1 CDS EC55989_1696 NC_011748.1 1766782 1767480 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein L complement(1766782..1767480) Escherichia coli 55989 7144627 YP_002402765.1 CDS EC55989_1697 NC_011748.1 1767490 1767819 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein M complement(1767490..1767819) Escherichia coli 55989 7144628 YP_002402766.1 CDS EC55989_1698 NC_011748.1 1767819 1770905 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail length tape measure protein from prophage complement(1767819..1770905) Escherichia coli 55989 7144629 YP_002402767.1 CDS EC55989_1699 NC_011748.1 1770847 1771176 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; minor tail protein T of prophage complement(1770847..1771176) Escherichia coli 55989 7144630 YP_002402768.1 CDS EC55989_1700 NC_011748.1 1771185 1771613 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; minor tail component of prophage complement(1771185..1771613) Escherichia coli 55989 7144631 YP_002402769.1 CDS EC55989_1701 NC_011748.1 1771632 1772450 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail protein V complement(1771632..1772450) Escherichia coli 55989 7144639 YP_002402770.1 CDS EC55989_1702 NC_011748.1 1772386 1772799 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein U complement(1772386..1772799) Escherichia coli 55989 7144640 YP_002402771.1 CDS EC55989_1703 NC_011748.1 1772784 1773362 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Minor tail protein Z (GPZ) of prophage complement(1772784..1773362) Escherichia coli 55989 7144641 YP_002402772.1 CDS EC55989_1704 NC_011748.1 1773374 1773649 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; prophage protein complement(1773374..1773649) Escherichia coli 55989 7144642 YP_002402773.1 CDS EC55989_1705 NC_011748.1 1773642 1774010 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; prophage protein complement(1773642..1774010) Escherichia coli 55989 7144643 YP_002402774.1 CDS EC55989_1706 NC_011748.1 1774052 1776271 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; ATP-dependent Clp protease proteolytic subunit complement(1774052..1776271) Escherichia coli 55989 7144644 YP_002402775.1 CDS EC55989_1707 NC_011748.1 1776024 1777604 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; portal protein (head-tail preconnector protein) from prophage complement(1776024..1777604) Escherichia coli 55989 7144645 YP_002402776.1 CDS EC55989_1708 NC_011748.1 1777532 1777750 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; prophage protein complement(1777532..1777750) Escherichia coli 55989 7144646 YP_002402777.1 CDS EC55989_1709 NC_011748.1 1777741 1779843 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; DNA packaging protein of prophage ( terminase large subunit) complement(1777741..1779843) Escherichia coli 55989 7144647 YP_002402778.1 CDS EC55989_1710 NC_011748.1 1779843 1780337 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; prophage protein complement(1779843..1780337) Escherichia coli 55989 7144648 YP_002402779.1 CDS EC55989_1711 NC_011748.1 1780890 1781096 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1780890..1781096) Escherichia coli 55989 7144649 YP_002402780.1 CDS ydfO NC_011748.1 1781384 1781794 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage 1781384..1781794 Escherichia coli 55989 7144650 YP_002402781.1 CDS rzpD NC_011748.1 1782114 1782578 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : enzyme; murein endopeptidase; DLP12 prophage complement(1782114..1782578) Escherichia coli 55989 7148438 YP_002402782.1 CDS EC55989_1714 NC_011748.1 1782580 1782753 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein complement(1782580..1782753) Escherichia coli 55989 7147598 YP_002402783.1 CDS ydfQ NC_011748.1 1782877 1783410 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane-associated lysozyme; Qin prophage complement(1782877..1783410) Escherichia coli 55989 7144651 YP_002402784.1 CDS essD NC_011748.1 1783785 1784000 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019562; Product type pe : enzyme; phage lysis protein S; DLP12 prophage complement(1783785..1784000) Escherichia coli 55989 7144652 YP_002402785.1 CDS EC55989_1718 NC_011748.1 1784252 1784647 R Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; tolA protein (fragment) of prophage complement(1784252..1784647) Escherichia coli 55989 7146024 YP_002402786.1 CDS tolA NC_011748.1 1784798 1785226 R Evidence 7 : Gene remnant; PubMedId : 2068069, 10404600, 8978668; Product type h : extrachromosomal origin; TolA protein (fragment) of prophage complement(1784798..1785226) Escherichia coli 55989 7144653 YP_002402787.1 CDS EC55989_1721 NC_011748.1 1785760 1786113 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(1785760..1786113) Escherichia coli 55989 7144654 YP_002402788.1 CDS EC55989_1722 NC_011748.1 1786258 1786422 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 1786258..1786422 Escherichia coli 55989 7145397 YP_002402789.1 CDS EC55989_1723 NC_011748.1 1786620 1787441 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; antitermination protein Q of prophage complement(1786620..1787441) Escherichia coli 55989 7145396 YP_002402790.1 CDS EC55989_1724 NC_011748.1 1787438 1787815 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; crossover junction endodeoxyribonuclease rusA (Holliday junction nuclease rusA) (Holliday juction resolvase) (Gp67) complement(1787438..1787815) Escherichia coli 55989 7144657 YP_002402791.1 CDS EC55989_1725 NC_011748.1 1787619 1787819 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1787619..1787819) Escherichia coli 55989 7144658 YP_002402792.1 CDS ydfU NC_011748.1 1787825 1788874 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage complement(1787825..1788874) Escherichia coli 55989 7144659 YP_002402793.1 CDS rem NC_011748.1 1789221 1789472 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2990907; Product type h : extrachromosomal origin; Qin prophage complement(1789221..1789472) Escherichia coli 55989 7148444 YP_002402794.1 CDS EC55989_1728 NC_011748.1 1790060 1790383 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(1790060..1790383) Escherichia coli 55989 7147372 YP_002402795.1 CDS EC55989_1729 NC_011748.1 1790432 1791469 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(1790432..1791469) Escherichia coli 55989 7144660 YP_002402796.1 CDS EC55989_1730 NC_011748.1 1791685 1792110 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein complement(1791685..1792110) Escherichia coli 55989 7144661 YP_002402797.1 CDS EC55989_1731 NC_011748.1 1792151 1793170 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1792151..1793170) Escherichia coli 55989 7144662 YP_002402798.1 CDS EC55989_1732 NC_011748.1 1793097 1793618 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1793097..1793618) Escherichia coli 55989 7144663 YP_002402799.1 CDS dicC NC_011748.1 1793602 1793832 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88232418, 3532030; Product type h : extrachromosomal origin; DNA-binding transcriptional regulator DicC complement(1793602..1793832) Escherichia coli 55989 7144664 YP_002402800.1 CDS dicA NC_011748.1 1793910 1794317 D The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown.; transcriptional repressor DicA 1793910..1794317 Escherichia coli 55989 7145910 YP_002402801.1 CDS ydfA NC_011748.1 1794486 1794641 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage 1794486..1794641 Escherichia coli 55989 7145908 YP_002402802.1 CDS EC55989_1736 NC_011748.1 1794601 1795218 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1794601..1795218 Escherichia coli 55989 7148429 YP_002402803.1 CDS EC55989_1737 NC_011748.1 1795600 1795893 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; regulator of cell division encoded by prophage 1795600..1795893 Escherichia coli 55989 7145913 YP_002402804.1 CDS ydfD NC_011748.1 1795890 1796081 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; Qin prophage 1795890..1796081 Escherichia coli 55989 7144666 YP_002402805.1 CDS EC55989_1739 NC_011748.1 1796175 1798646 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; exonuclease from phage origin 1796175..1798646 Escherichia coli 55989 7148433 YP_002402806.1 CDS xis NC_011748.1 1798719 1798970 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; prophage excisionase 1798719..1798970 Escherichia coli 55989 7144667 YP_002402807.1 CDS intQ NC_011748.1 1798990 1800285 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; defective integrase; Qin prophage 1798990..1800285 Escherichia coli 55989 7147991 YP_002402808.1 CDS ynfP NC_011748.1 1800305 1800415 R Evidence 6 : Doubtful CDS; hypothetical protein complement(1800305..1800415) Escherichia coli 55989 7146609 YP_002402809.1 CDS EC55989_1744 NC_011748.1 1801318 1802526 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L 1801318..1802526 Escherichia coli 55989 7147441 YP_002402810.1 CDS rspA NC_011748.1 1802842 1804056 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : enzyme; enolase/dehydratase complement(1802842..1804056) Escherichia coli 55989 7147540 YP_002402811.1 CDS ynfA NC_011748.1 1804262 1804588 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(1804262..1804588) Escherichia coli 55989 7147537 YP_002402812.1 CDS ynfB NC_011748.1 1804723 1805064 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1804723..1805064 Escherichia coli 55989 7149310 YP_002402813.1 CDS speG NC_011748.1 1805099 1805659 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94357898; Product type e : enzyme; spermidine N1-acetyltransferase 1805099..1805659 Escherichia coli 55989 7149311 YP_002402814.1 CDS ynfC NC_011748.1 1805662 1806372 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1805662..1806372) Escherichia coli 55989 7147691 YP_002402815.1 CDS ynfD NC_011748.1 1806480 1806785 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9868784; hypothetical protein 1806480..1806785 Escherichia coli 55989 7149312 YP_002402816.1 CDS ynfE NC_011748.1 1806984 1809410 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme; oxidoreductase subunit 1806984..1809410 Escherichia coli 55989 7149313 YP_002402817.1 CDS ynfF NC_011748.1 1809471 1811894 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type e : enzyme; oxidoreductase subunit 1809471..1811894 Escherichia coli 55989 7149314 YP_002402818.1 CDS ynfG NC_011748.1 1811905 1812522 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type c : carrier; oxidoreductase, Fe-S subunit 1811905..1812522 Escherichia coli 55989 7149315 YP_002402819.1 CDS ynfH NC_011748.1 1812524 1813378 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14522592; Product type m : membrane component; oxidoreductase, membrane subunit 1812524..1813378 Escherichia coli 55989 7149316 YP_002402820.1 CDS dmsD NC_011748.1 1813421 1814035 D binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane; twin-argninine leader-binding protein DmsD 1813421..1814035 Escherichia coli 55989 7149317 YP_002402821.1 CDS clcB NC_011748.1 1814230 1815486 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12384697; Product type pt : transporter; voltage-gated ClC-type chloride channel ClcB 1814230..1815486 Escherichia coli 55989 7145931 YP_002402822.1 CDS ynfK NC_011748.1 1815439 1816134 R DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium; dithiobiotin synthetase complement(1815439..1816134) Escherichia coli 55989 7145719 YP_002402823.1 CDS dgsA NC_011748.1 1816259 1817479 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10318813, 20490366, 6989798, 99340206, 99395104, 99398866, 7766024; Product type r : regulator; DNA-binding transcriptional repressor complement(1816259..1817479) Escherichia coli 55989 7149318 YP_002402824.1 CDS ynfL NC_011748.1 1817614 1818507 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(1817614..1818507) Escherichia coli 55989 7145900 YP_002402825.1 CDS ynfM NC_011748.1 1818614 1819867 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter; MFS type 1818614..1819867 Escherichia coli 55989 7149319 YP_002402826.1 CDS asr NC_011748.1 1820291 1820599 D required for growth and survival under moderately acid conditions; acid shock protein 1820291..1820599 Escherichia coli 55989 7149320 YP_002402827.1 CDS ydgD NC_011748.1 1820875 1821696 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; metallopeptidase 1820875..1821696 Escherichia coli 55989 7145574 YP_002402828.1 CDS mdtI NC_011748.1 1821735 1822064 R with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtI complement(1821735..1822064) Escherichia coli 55989 7148448 YP_002402829.1 CDS mdtJ NC_011748.1 1822051 1822416 R with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS; multidrug efflux system protein MdtJ complement(1822051..1822416) Escherichia coli 55989 7146810 YP_002402830.1 CDS tqsA NC_011748.1 1822828 1823862 D transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes; transporter 1822828..1823862 Escherichia coli 55989 7146811 YP_002402831.1 CDS pntB NC_011748.1 1823887 1825275 R catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme; pyridine nucleotide transhydrogenase complement(1823887..1825275) Escherichia coli 55989 7148449 YP_002402832.1 CDS pntA NC_011748.1 1825286 1826818 R forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm; NAD(P) transhydrogenase subunit alpha complement(1825286..1826818) Escherichia coli 55989 7147205 YP_002402833.1 CDS ydgH NC_011748.1 1827342 1828286 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1827342..1828286 Escherichia coli 55989 7147204 YP_002402834.1 CDS ydgI NC_011748.1 1828472 1829854 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1311296; Product type pt : transporter; arginine/ornithine antiporter transporter 1828472..1829854 Escherichia coli 55989 7148450 YP_002402835.1 CDS folM NC_011748.1 1829891 1830613 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14617668; Product type e : enzyme; short chain dehydrogenase 1829891..1830613 Escherichia coli 55989 7148451 YP_002402836.1 CDS ydgC NC_011748.1 1830610 1830945 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein associated with alginate biosynthesis complement(1830610..1830945) Escherichia coli 55989 7146174 YP_002402837.1 CDS rstA NC_011748.1 1831065 1831793 D response regulator in two-component regulatory system with RstB; DNA-binding transcriptional regulator RstA 1831065..1831793 Escherichia coli 55989 7148447 YP_002402838.1 CDS rstB NC_011748.1 1831797 1833098 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93086426, 1495392, 1925016, 2646639; Product type r : regulator; sensor protein RstB 1831797..1833098 Escherichia coli 55989 7147543 YP_002402839.1 CDS tus NC_011748.1 1833174 1834103 D binds to DNA replication terminator sequences to prevent passage of replication forks; DNA replication terminus site-binding protein 1833174..1834103 Escherichia coli 55989 7147544 YP_002402840.1 CDS fumC NC_011748.1 1834100 1835503 R class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle; fumarate hydratase complement(1834100..1835503) Escherichia coli 55989 7147874 YP_002402841.1 CDS fumA NC_011748.1 1835646 1837292 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88193096, 88268900, 92011457, 3005475, 6328431, 9298646; Product type e : enzyme; fumarate hydratase (fumarase A), aerobic Class I complement(1835646..1837292) Escherichia coli 55989 7146232 YP_002402842.1 CDS manA NC_011748.1 1837491 1838666 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 6397402; Product type e : enzyme; mannose-6-phosphate isomerase 1837491..1838666 Escherichia coli 55989 7146230 YP_002402843.1 CDS ydgA NC_011748.1 1838767 1840275 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1838767..1840275 Escherichia coli 55989 7146781 YP_002402844.1 CDS uidC NC_011748.1 1840320 1841585 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15774881; Product type t : transporter; outer membrane porin protein complement(1840320..1841585) Escherichia coli 55989 7148446 YP_002402845.1 CDS uidB NC_011748.1 1841624 1842997 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3534890; Product type t : transporter; glucuronide transporter complement(1841624..1842997) Escherichia coli 55989 7147911 YP_002402846.1 CDS uidA NC_011748.1 1842994 1844805 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87041472, 88038341, 2103475, 8125312; Product type e : enzyme; beta-D-glucuronidase complement(1842994..1844805) Escherichia coli 55989 7147910 YP_002402847.1 CDS uidR NC_011748.1 1845194 1845784 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88038341, 2823062, 3934044, 11115104; Product type r : regulator; DNA-binding transcriptional repressor complement(1845194..1845784) Escherichia coli 55989 7147909 YP_002402848.1 CDS hdhA NC_011748.1 1846013 1846780 R Acts on the hydroxyl group at position 7 of the steroid frame; 7-alpha-hydroxysteroid dehydrogenase complement(1846013..1846780) Escherichia coli 55989 7147912 YP_002402849.1 CDS malI NC_011748.1 1846892 1847920 R regulates malXY which are involved in maltose-glucose transport; DNA-binding transcriptional repressor MalI complement(1846892..1847920) Escherichia coli 55989 7146405 YP_002402850.1 CDS malX NC_011748.1 1848095 1849687 D phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site; bifunctional PTS system maltose and glucose-specific transporter subunits IICB 1848095..1849687 Escherichia coli 55989 7146771 YP_002402851.1 CDS malY NC_011748.1 1849697 1850869 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20164451, 7665481, 91310596; Product type e : enzyme; bifunctional beta-cystathionase and regulator of maltose regulon 1849697..1850869 Escherichia coli 55989 7146778 YP_002402852.1 CDS add NC_011748.1 1850973 1851974 D catalyzes the formation of inosine from adenosine; adenosine deaminase 1850973..1851974 Escherichia coli 55989 7146779 YP_002402853.1 CDS ydgJ NC_011748.1 1852009 1853049 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase complement(1852009..1853049) Escherichia coli 55989 7145453 YP_002402854.1 CDS blr NC_011748.1 1853217 1853417 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20392465, 10931331; Product type m : membrane component; beta-lactam resistance membrane protein 1853217..1853417 Escherichia coli 55989 7148452 YP_002402855.1 CDS ydgT NC_011748.1 1853690 1853905 D YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes; oriC-binding nucleoid-associated protein 1853690..1853905 Escherichia coli 55989 7145634 YP_002402856.1 CDS ydgK NC_011748.1 1853991 1854431 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1853991..1854431 Escherichia coli 55989 7148455 YP_002402857.1 CDS rsxA NC_011748.1 1854508 1855089 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411911, 10637328, 12773378; Product type pm : membrane component; Na(+)-translocating NADH-quinone reductase subunit E 1854508..1855089 Escherichia coli 55989 7148453 YP_002402858.1 CDS rsxB NC_011748.1 1855089 1855667 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfB 1855089..1855667 Escherichia coli 55989 7147546 YP_002402859.1 CDS rsxC NC_011748.1 1855660 1857786 D part of membrane-bound complex thought to be involved in electron transport to nitrogen; electron transport complex protein RnfC 1855660..1857786 Escherichia coli 55989 7147547 YP_002402860.1 CDS rnfD NC_011748.1 1857787 1858845 D RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents; electron transport complex protein RnfD 1857787..1858845 Escherichia coli 55989 7147548 YP_002402861.1 CDS rsxG NC_011748.1 1858849 1859469 D part of membrane-bound complex hought to be involved in electron transport to nitrogen; electron transport complex protein RnfG 1858849..1859469 Escherichia coli 55989 7147549 YP_002402862.1 CDS rsxE NC_011748.1 1859473 1860168 D in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase; electron transport complex protein RsxE 1859473..1860168 Escherichia coli 55989 7147551 YP_002402863.1 CDS nth NC_011748.1 1860168 1860803 D DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines; endonuclease III 1860168..1860803 Escherichia coli 55989 7147550 YP_002402864.1 CDS tppB NC_011748.1 1861414 1862916 D mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation; tripeptide transporter permease 1861414..1862916 Escherichia coli 55989 7147035 YP_002402865.1 CDS gst NC_011748.1 1863022 1863627 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95096109, 2185038, 9680481; Product type e : enzyme; glutathionine S-transferase 1863022..1863627 Escherichia coli 55989 7148454 YP_002402866.1 CDS pdxY NC_011748.1 1863671 1864534 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxamine kinase complement(1863671..1864534) Escherichia coli 55989 7146377 YP_002402867.1 CDS tyrS NC_011748.1 1864593 1865867 R catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr); tyrosyl-tRNA synthetase complement(1864593..1865867) Escherichia coli 55989 7147129 YP_002402868.1 CDS pdxH NC_011748.1 1865996 1866652 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate; pyridoxamine 5'-phosphate oxidase complement(1865996..1866652) Escherichia coli 55989 7147885 YP_002402869.1 CDS ydhA NC_011748.1 1866711 1867040 R MliC; membrane-bound lysozyme inhibitor of c-type lysozyme; lysozyme inhibitor complement(1866711..1867040) Escherichia coli 55989 7147126 YP_002402870.1 CDS anmK NC_011748.1 1867138 1868247 R catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling; anhydro-N-acetylmuramic acid kinase complement(1867138..1868247) Escherichia coli 55989 7148456 YP_002402871.1 CDS slyB NC_011748.1 1868521 1868988 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8544813; Product type lp : lipoprotein; outer membrane lipoprotein 1868521..1868988 Escherichia coli 55989 7145501 YP_002402872.1 CDS slyA NC_011748.1 1869035 1869469 R Transcription regulator that can both activate or repress expression; transcriptional regulator SlyA complement(1869035..1869469) Escherichia coli 55989 7147663 YP_002402873.1 CDS ydhI NC_011748.1 1869670 1869906 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1869670..1869906 Escherichia coli 55989 7147662 YP_002402874.1 CDS ydhJ NC_011748.1 1869909 1870766 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12900028; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 1869909..1870766 Escherichia coli 55989 7148461 YP_002402875.1 CDS ydhK NC_011748.1 1870766 1872778 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1870766..1872778 Escherichia coli 55989 7148462 YP_002402876.1 CDS sodC NC_011748.1 1872779 1873300 R SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water; superoxide dismutase complement(1872779..1873300) Escherichia coli 55989 7148463 YP_002402877.1 CDS ydhF NC_011748.1 1873381 1874277 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase complement(1873381..1874277) Escherichia coli 55989 7147673 YP_002402878.1 CDS ydhL NC_011748.1 1874326 1874736 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1874326..1874736) Escherichia coli 55989 7148460 YP_002402879.1 CDS ydhM NC_011748.1 1874752 1875267 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 1874752..1875267 Escherichia coli 55989 7148464 YP_002402880.1 CDS nemA NC_011748.1 1875304 1876401 D FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide; N-ethylmaleimide reductase 1875304..1876401 Escherichia coli 55989 7148465 YP_002402881.1 CDS gloA NC_011748.1 1876482 1876889 D Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione; glyoxalase I 1876482..1876889 Escherichia coli 55989 7146984 YP_002402882.1 CDS rnt NC_011748.1 1876992 1877639 D Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A); ribonuclease T 1876992..1877639 Escherichia coli 55989 7146313 YP_002402883.1 CDS lhr NC_011748.1 1877732 1882348 D similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli; ATP-dependent helicase Lhr 1877732..1882348 Escherichia coli 55989 7147456 YP_002402884.1 CDS ydhD NC_011748.1 1882399 1882746 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15833738, 15840565, 11950925, 12730244; Product type e : enzyme; hypothetical protein complement(1882399..1882746) Escherichia coli 55989 7146699 YP_002402885.1 CDS ydhO NC_011748.1 1883080 1883895 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase 1883080..1883895 Escherichia coli 55989 7148459 YP_002402886.1 CDS sodB NC_011748.1 1884023 1884604 D SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals; superoxide dismutase 1884023..1884604 Escherichia coli 55989 7148466 YP_002402887.1 CDS ydhP NC_011748.1 1884750 1885919 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; efflux protein; MFS family complement(1884750..1885919) Escherichia coli 55989 7147672 YP_002402888.1 CDS purR NC_011748.1 1886473 1887498 D binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers; DNA-binding transcriptional repressor PurR 1886473..1887498 Escherichia coli 55989 7148467 YP_002402889.1 CDS ydhB NC_011748.1 1887495 1888427 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404765; Product type pr : regulator; DNA-binding transcriptional regulator complement(1887495..1888427) Escherichia coli 55989 7147303 YP_002402890.1 CDS ydhC NC_011748.1 1888540 1889751 D uncharacterized member of the major facilitator superfamily (MFS); inner membrane transport protein YdhC 1888540..1889751 Escherichia coli 55989 7148457 YP_002402891.1 CDS cfa NC_011748.1 1890042 1891190 D catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge; cyclopropane-fatty-acyl-phospholipid synthase 1890042..1891190 Escherichia coli 55989 7148458 YP_002402892.1 CDS ribC NC_011748.1 1891230 1891871 R catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine; riboflavin synthase subunit alpha complement(1891230..1891871) Escherichia coli 55989 7145687 YP_002402893.1 CDS mdtK NC_011748.1 1892086 1893459 D NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones; multidrug efflux protein 1892086..1893459 Escherichia coli 55989 7147411 YP_002402894.1 CDS ydhQ NC_011748.1 1893500 1894756 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1893500..1894756) Escherichia coli 55989 7146812 YP_002402895.1 CDS ydhR NC_011748.1 1895329 1895634 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1895329..1895634 Escherichia coli 55989 7145330 YP_002402896.1 CDS ydhS NC_011748.1 1895760 1897364 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1895760..1897364 Escherichia coli 55989 7148469 YP_002402897.1 CDS ydhT NC_011748.1 1897376 1898188 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1897376..1898188) Escherichia coli 55989 7148470 YP_002402898.1 CDS ydhU NC_011748.1 1898192 1898977 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; cytochrome b subunit of a reductase complement(1898192..1898977) Escherichia coli 55989 7148471 YP_002402899.1 CDS ydhX NC_011748.1 1898974 1899642 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; 4Fe-4S ferredoxin complement(1898974..1899642) Escherichia coli 55989 7148472 YP_002402900.1 CDS ydhW NC_011748.1 1899706 1900353 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1899706..1900353) Escherichia coli 55989 7148475 YP_002402901.1 CDS ydhV NC_011748.1 1900357 1902459 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase complement(1900357..1902459) Escherichia coli 55989 7148474 YP_002402902.1 CDS ydhY NC_011748.1 1902480 1903106 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; hypothetical protein complement(1902480..1903106) Escherichia coli 55989 7148473 YP_002402903.1 CDS ydhZ NC_011748.1 1903562 1903771 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1903562..1903771) Escherichia coli 55989 7148476 YP_002402904.1 CDS pykF NC_011748.1 1904328 1905740 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 1904328..1905740 Escherichia coli 55989 7148477 YP_002402905.1 CDS lpp NC_011748.1 1906051 1906287 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 334727, 338599, 322142, 353292, 391404, 4261992, 4575979, 6765942; Product type lp : lipoprotein; murein lipoprotein 1906051..1906287 Escherichia coli 55989 7147316 YP_002402906.1 CDS ynhG NC_011748.1 1906351 1907355 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1906351..1907355) Escherichia coli 55989 7146732 YP_002402907.1 CDS sufE NC_011748.1 1907504 1907920 R Acts with SufS to catalyze the formation of L-alanine from L-cysteine; cysteine desufuration protein SufE complement(1907504..1907920) Escherichia coli 55989 7149323 YP_002402908.1 CDS sufS NC_011748.1 1907933 1909153 R catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine; bifunctional cysteine desulfurase/selenocysteine lyase complement(1907933..1909153) Escherichia coli 55989 7147734 YP_002402909.1 CDS sufD NC_011748.1 1909150 1910421 R with SufBC activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufD complement(1909150..1910421) Escherichia coli 55989 7147736 YP_002402910.1 CDS sufC NC_011748.1 1910396 1911142 R part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE; cysteine desulfurase complement(1910396..1911142) Escherichia coli 55989 7147733 YP_002402911.1 CDS sufB NC_011748.1 1911152 1912639 R with SufCD activates cysteine desulfurase SufS; cysteine desulfurase activator complex subunit SufB complement(1911152..1912639) Escherichia coli 55989 7147732 YP_002402912.1 CDS sufA NC_011748.1 1912648 1913016 R functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein; iron-sulfur cluster assembly scaffold protein complement(1912648..1913016) Escherichia coli 55989 7147731 YP_002402913.1 CDS ydiH NC_011748.1 1913565 1913834 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1913565..1913834) Escherichia coli 55989 7147576 YP_002402914.1 CDS ydiI NC_011748.1 1913853 1914263 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15808744; Product type pe : enzyme; hypothetical protein complement(1913853..1914263) Escherichia coli 55989 7148483 YP_002402915.1 CDS ydiJ NC_011748.1 1914260 1917316 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11102686; Product type pe : enzyme; FAD-linked oxidoreductase complement(1914260..1917316) Escherichia coli 55989 7148484 YP_002402916.1 CDS ydiK NC_011748.1 1917705 1918817 D YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function; inner membrane protein 1917705..1918817 Escherichia coli 55989 7148485 YP_002402917.1 CDS ydiL NC_011748.1 1919246 1919602 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1919246..1919602 Escherichia coli 55989 7147504 YP_002402918.1 CDS ydiM NC_011748.1 1919702 1920916 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter; MFS superfamily 1919702..1920916 Escherichia coli 55989 7148487 YP_002402919.1 CDS ydiN NC_011748.1 1921143 1922408 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 1921143..1922408 Escherichia coli 55989 7148488 YP_002402920.1 CDS ydiB NC_011748.1 1922420 1923286 D YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate; quinate/shikimate dehydrogenase 1922420..1923286 Escherichia coli 55989 7148489 YP_002402921.1 CDS aroD NC_011748.1 1923317 1924075 D catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis; 3-dehydroquinate dehydratase 1923317..1924075 Escherichia coli 55989 7148479 YP_002402922.1 CDS ydiF NC_011748.1 1924219 1925814 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16253988; Product type e : enzyme; short chain acyl-CoA transferase: fused alpha subunit ; beta subunit 1924219..1925814 Escherichia coli 55989 7145542 YP_002402923.1 CDS ydiO NC_011748.1 1925828 1926979 D may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; acyl-CoA dehydrogenase 1925828..1926979 Escherichia coli 55989 7148482 YP_002402924.1 CDS ydiP NC_011748.1 1927022 1927933 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(1927022..1927933) Escherichia coli 55989 7148490 YP_002402925.1 CDS EC55989_1864 NC_011748.1 1928036 1928212 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1928036..1928212) Escherichia coli 55989 7148491 YP_002402926.1 CDS ydiQ NC_011748.1 1928249 1929013 D YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain; electron transfer flavoprotein YdiQ 1928249..1929013 Escherichia coli 55989 7144669 YP_002402927.1 CDS ydiR NC_011748.1 1929033 1929971 D May play a role in a redox process; electron transfer flavoprotein subunit YdiR 1929033..1929971 Escherichia coli 55989 7148492 YP_002402928.1 CDS ydiS NC_011748.1 1930027 1931316 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; hypothetical protein 1930027..1931316 Escherichia coli 55989 7148493 YP_002402929.1 CDS ydiT NC_011748.1 1931313 1931606 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; 4Fe-4S ferredoxin 1931313..1931606 Escherichia coli 55989 7148494 YP_002402930.1 CDS ydiD NC_011748.1 1931609 1933309 D acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids; short chain acyl-CoA synthetase 1931609..1933309 Escherichia coli 55989 7148495 YP_002402931.1 CDS pps NC_011748.1 1933366 1935744 R catalyzes the formation of phosphoenolpyruvate from pyruvate; phosphoenolpyruvate synthase complement(1933366..1935744) Escherichia coli 55989 7148480 YP_002402932.1 CDS ydiA NC_011748.1 1936077 1936910 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1936077..1936910 Escherichia coli 55989 7147234 YP_002402933.1 CDS aroH NC_011748.1 1937067 1938113 D tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate; phospho-2-dehydro-3-deoxyheptonate aldolase 1937067..1938113 Escherichia coli 55989 7148478 YP_002402934.1 CDS ydiE NC_011748.1 1938245 1938436 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15039350; hypothetical protein 1938245..1938436 Escherichia coli 55989 7145546 YP_002402935.1 CDS ydiU NC_011748.1 1938440 1939876 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1938440..1939876) Escherichia coli 55989 7148481 YP_002402936.1 CDS ydiV NC_011748.1 1939939 1940652 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1939939..1940652) Escherichia coli 55989 7148496 YP_002402937.1 CDS nlpC NC_011748.1 1940899 1941363 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12620121; Product type lp : lipoprotein; peptidase lipoprotein complement(1940899..1941363) Escherichia coli 55989 7148497 YP_002402938.1 CDS btuD NC_011748.1 1941441 1942190 R ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell; vitamin B12-transporter ATPase complement(1941441..1942190) Escherichia coli 55989 7147008 YP_002402939.1 CDS btuE NC_011748.1 1942190 1942741 R similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane; glutathione peroxidase complement(1942190..1942741) Escherichia coli 55989 7145641 YP_002402940.1 CDS btuC NC_011748.1 1942804 1943784 R with BtuD and BtuF transports vitamin B12 into the cell; vtamin B12-transporter permease complement(1942804..1943784) Escherichia coli 55989 7145642 YP_002402941.1 CDS ihfA NC_011748.1 1943885 1944184 R This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control; integration host factor subunit alpha complement(1943885..1944184) Escherichia coli 55989 7145640 YP_002402942.1 CDS pheT NC_011748.1 1944189 1946576 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily; phenylalanyl-tRNA synthetase subunit beta complement(1944189..1946576) Escherichia coli 55989 7146546 YP_002402943.1 CDS pheS NC_011748.1 1946591 1947574 R catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily; phenylalanyl-tRNA synthetase subunit alpha complement(1946591..1947574) Escherichia coli 55989 7147162 YP_002402945.1 CDS rplT NC_011748.1 1948024 1948380 R binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit; 50S ribosomal protein L20 complement(1948024..1948380) Escherichia coli 55989 7147159 YP_002402946.1 CDS rpmI NC_011748.1 1948433 1948630 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93085722, 10094780, 3298224, 3542048, 6325158; Product type s : structure; 50S ribosomal protein L35 complement(1948433..1948630) Escherichia coli 55989 7147480 YP_002402947.1 CDS thrS NC_011748.1 1949273 1951201 R catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; threonyl-tRNA synthetase complement(1949273..1951201) Escherichia coli 55989 7146567 YP_002402948.1 CDS ydiY NC_011748.1 1953959 1954717 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1953959..1954717) Escherichia coli 55989 7144671 YP_002402949.1 CDS pfkB NC_011748.1 1955004 1955933 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 78194149, 88292964, 6235149, 6310120; Product type e : enzyme; 6-phosphofructokinase 1955004..1955933 Escherichia coli 55989 7148498 YP_002402950.1 CDS ydiZ NC_011748.1 1956034 1956324 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1956034..1956324 Escherichia coli 55989 7147140 YP_002402951.1 CDS yniA NC_011748.1 1956430 1957290 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; phosphotransferase/kinase 1956430..1957290 Escherichia coli 55989 7148499 YP_002402952.1 CDS yniB NC_011748.1 1957331 1957867 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(1957331..1957867) Escherichia coli 55989 7149324 YP_002402953.1 CDS yniC NC_011748.1 1958014 1958682 D YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate; 2-deoxyglucose-6-phosphatase 1958014..1958682 Escherichia coli 55989 7149325 YP_002402954.1 CDS ydjM NC_011748.1 1958845 1959435 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10760155; Product type pm : membrane component; hypothetical protein 1958845..1959435 Escherichia coli 55989 7149326 YP_002402955.1 CDS ydjN NC_011748.1 1959568 1960959 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; cation-acid symporter 1959568..1960959 Escherichia coli 55989 7148509 YP_002402956.1 CDS cedA NC_011748.1 1962055 1962318 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9427399; Product type cp : cell process; cell division modulator complement(1962055..1962318) Escherichia coli 55989 7148512 YP_002402957.1 CDS katE NC_011748.1 1962501 1964762 D Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide; hydroperoxidase II 1962501..1964762 Escherichia coli 55989 7145686 YP_002402958.1 CDS chbG NC_011748.1 1964809 1965567 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20042356, 1987146, 2179047, 8121401, 9405618; hypothetical protein complement(1964809..1965567) Escherichia coli 55989 7146645 YP_002402959.1 CDS chbF NC_011748.1 1965580 1966932 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20042356, 90185127, 9405618; Product type e : enzyme; cryptic phospho-beta-glucosidase, NAD(P)-binding complement(1965580..1966932) Escherichia coli 55989 7145695 YP_002402960.1 CDS chbR NC_011748.1 1967037 1967879 R represses the celABCDF-ydjC operon involved in carbon uptake; DNA-binding transcriptional regulator ChbR complement(1967037..1967879) Escherichia coli 55989 7145694 YP_002402961.1 CDS chbA NC_011748.1 1967887 1968237 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIA complement(1967887..1968237) Escherichia coli 55989 7145696 YP_002402962.1 CDS chbC NC_011748.1 1968288 1969646 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC complement(1968288..1969646) Escherichia coli 55989 7145691 YP_002402963.1 CDS chbB NC_011748.1 1969731 1970051 R catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system N,N'-diacetylchitobiose-specific transporter subunit IIB complement(1969731..1970051) Escherichia coli 55989 7145693 YP_002402964.1 CDS osmE NC_011748.1 1970350 1970688 R osmotically-inducible lipoprotein E; activator of ntr-like gene protein; DNA-binding transcriptional activator OsmE complement(1970350..1970688) Escherichia coli 55989 7145692 YP_002402965.1 CDS nadE NC_011748.1 1970890 1971717 D catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers; NAD synthetase 1970890..1971717 Escherichia coli 55989 7147083 YP_002402966.1 CDS ydjQ NC_011748.1 1971947 1972834 D 3' incision activity; acts with UvrC; nucleotide excision repair endonuclease 1971947..1972834 Escherichia coli 55989 7146946 YP_002402967.1 CDS ydjR NC_011748.1 1972794 1973369 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21862596; hypothetical protein complement(1972794..1973369) Escherichia coli 55989 7148513 YP_002402968.1 CDS spy NC_011748.1 1973572 1974057 R periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP; hypothetical protein complement(1973572..1974057) Escherichia coli 55989 7148514 YP_002402969.1 CDS astE NC_011748.1 1974387 1975355 R catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism; succinylglutamate desuccinylase complement(1974387..1975355) Escherichia coli 55989 7147697 YP_002402970.1 CDS astB NC_011748.1 1975348 1976691 R catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation; succinylarginine dihydrolase complement(1975348..1976691) Escherichia coli 55989 7145579 YP_002402971.1 CDS astD NC_011748.1 1976688 1978166 R a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH; succinylglutamic semialdehyde dehydrogenase complement(1976688..1978166) Escherichia coli 55989 7145576 YP_002402972.1 CDS astA NC_011748.1 1978163 1979197 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14675764, 98361920; Product type e : enzyme; arginine succinyltransferase complement(1978163..1979197) Escherichia coli 55989 7145578 YP_002402973.1 CDS astC NC_011748.1 1979194 1980414 R catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate; bifunctional succinylornithine transaminase/acetylornithine transaminase complement(1979194..1980414) Escherichia coli 55989 7145575 YP_002402974.1 CDS xthA NC_011748.1 1980860 1981666 D removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction; exonuclease III 1980860..1981666 Escherichia coli 55989 7145577 YP_002402975.1 CDS ydjX NC_011748.1 1981833 1982543 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1981833..1982543 Escherichia coli 55989 7147994 YP_002402976.1 CDS ydjY NC_011748.1 1982548 1983225 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1982548..1983225 Escherichia coli 55989 7148515 YP_002402977.1 CDS ydjZ NC_011748.1 1983239 1983946 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 1983239..1983946 Escherichia coli 55989 7148516 YP_002402978.1 CDS ynjA NC_011748.1 1983946 1984494 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1983946..1984494 Escherichia coli 55989 7148517 YP_002402979.1 CDS ynjB NC_011748.1 1984504 1985670 D Evidence 4 : Homologs of previously reported genes of unknown function; ABC transporter substrate-binding protein 1984504..1985670 Escherichia coli 55989 7149327 YP_002402980.1 CDS ynjC NC_011748.1 1985688 1987178 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; fused transporter subunits of ABC superfamily: membrane components 1985688..1987178 Escherichia coli 55989 7149328 YP_002402981.1 CDS ynjD NC_011748.1 1987178 1987831 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sulfate/thiosulfate transporter subunit: ATP-binding component of ABC superfamily transporter 1987178..1987831 Escherichia coli 55989 7149329 YP_002402982.1 CDS ynjE NC_011748.1 1987898 1989205 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; thiosulfate sulfur transferase / thiosulfate binding protein 1987898..1989205 Escherichia coli 55989 7149330 YP_002402983.1 CDS ynjF NC_011748.1 1989214 1989834 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type m : membrane component; phosphatidyl transferase, inner membrane protein complement(1989214..1989834) Escherichia coli 55989 7149331 YP_002402984.1 CDS nudG NC_011748.1 1989921 1990328 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101911; Product type e : enzyme; pyrimidine (deoxy)nucleoside triphosphate pyrophosphohydrolase 1989921..1990328 Escherichia coli 55989 7149332 YP_002402985.1 CDS gdhA NC_011748.1 1990802 1992145 D converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer; glutamate dehydrogenase 1990802..1992145 Escherichia coli 55989 7147041 YP_002402986.1 CDS ynjI NC_011748.1 1992262 1993302 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(1992262..1993302) Escherichia coli 55989 7146280 YP_002402987.1 CDS topB NC_011748.1 1993430 1995391 R decatenates replicating daughter chromosomes; DNA topoisomerase III complement(1993430..1995391) Escherichia coli 55989 7149333 YP_002402988.1 CDS selD NC_011748.1 1995396 1996439 R catalyzes the formation of selenophosphate from selenide and ATP; selenophosphate synthetase complement(1995396..1996439) Escherichia coli 55989 7147819 YP_002402989.1 CDS EC55989_1932 NC_011748.1 1996381 1996530 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(1996381..1996530) Escherichia coli 55989 7147630 YP_002402990.1 CDS ydjA NC_011748.1 1996556 1997107 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein complement(1996556..1997107) Escherichia coli 55989 7144672 YP_002402991.1 CDS EC55989_1934 NC_011748.1 1997161 1997325 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 1997161..1997325 Escherichia coli 55989 7148500 YP_002402992.1 CDS sppA NC_011748.1 1997268 1999124 D SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane; protease 4 1997268..1999124 Escherichia coli 55989 7144673 YP_002402993.1 CDS ansA NC_011748.1 1999291 2000307 D converts asparagine to aspartate and ammonia; asparaginase 1999291..2000307 Escherichia coli 55989 7147694 YP_002402994.1 CDS pncA NC_011748.1 2000318 2000959 D catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide; nicotinamidase/pyrazinamidase 2000318..2000959 Escherichia coli 55989 7145502 YP_002402995.1 CDS ydjE NC_011748.1 2001052 2002410 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter; MFS superfamily complement(2001052..2002410) Escherichia coli 55989 7147201 YP_002402996.1 CDS ydjF NC_011748.1 2002527 2003285 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(2002527..2003285) Escherichia coli 55989 7148501 YP_002402997.1 CDS ydjG NC_011748.1 2003422 2004402 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase complement(2003422..2004402) Escherichia coli 55989 7148502 YP_002402998.1 CDS ydjH NC_011748.1 2004412 2005359 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; sugar kinase complement(2004412..2005359) Escherichia coli 55989 7148503 YP_002402999.1 CDS ydjI NC_011748.1 2005364 2006200 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; aldolase complement(2005364..2006200) Escherichia coli 55989 7148504 YP_002403000.1 CDS ydjJ NC_011748.1 2006221 2007198 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12897001; Product type pe : enzyme; iditol dehydrogenase complement(2006221..2007198) Escherichia coli 55989 7148505 YP_002403001.1 CDS ydjK NC_011748.1 2007280 2008659 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter; MFS superfamily complement(2007280..2008659) Escherichia coli 55989 7148506 YP_002403002.1 CDS ydjL NC_011748.1 2008686 2009762 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase, Zn-dependent and NAD(P)-binding complement(2008686..2009762) Escherichia coli 55989 7148507 YP_002403003.1 CDS yeaC NC_011748.1 2010132 2010404 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2010132..2010404) Escherichia coli 55989 7148508 YP_002403004.1 CDS msrB NC_011748.1 2010446 2010859 R this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress; methionine sulfoxide reductase B complement(2010446..2010859) Escherichia coli 55989 7148519 YP_002403005.1 CDS gapA NC_011748.1 2011201 2012196 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 775311, 94131963, 98361923, 1862091, 2124629, 2990926, 7896119, 8636984, 9298646; Product type e : enzyme; glyceraldehyde-3-phosphate dehydrogenase 2011201..2012196 Escherichia coli 55989 7146911 YP_002403006.1 CDS yeaD NC_011748.1 2012280 2013164 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2012280..2013164 Escherichia coli 55989 7146256 YP_002403007.1 CDS yeaE NC_011748.1 2013215 2014069 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase complement(2013215..2014069) Escherichia coli 55989 7148520 YP_002403008.1 CDS mipA NC_011748.1 2014159 2014905 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10037771, 20267815; Product type f : factor; scaffolding protein for murein synthesizing machinery complement(2014159..2014905) Escherichia coli 55989 7148521 YP_002403009.1 CDS yeaG NC_011748.1 2015341 2017275 D Evidence 4 : Homologs of previously reported genes of unknown function; nucleoside triphosphate hydrolase domain 2015341..2017275 Escherichia coli 55989 7146861 YP_002403010.1 CDS yeaH NC_011748.1 2017388 2018671 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2017388..2018671 Escherichia coli 55989 7148522 YP_002403011.1 CDS yeaI NC_011748.1 2018818 2020293 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; diguanylate cyclase 2018818..2020293 Escherichia coli 55989 7148523 YP_002403012.1 CDS yeaJ NC_011748.1 2020474 2021964 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; diguanylate cyclase 2020474..2021964 Escherichia coli 55989 7148524 YP_002403013.1 CDS yeaK NC_011748.1 2022007 2022510 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2022007..2022510 Escherichia coli 55989 7148525 YP_002403014.1 CDS EC55989_1957 NC_011748.1 2022511 2022663 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2022511..2022663) Escherichia coli 55989 7148526 YP_002403015.1 CDS yeaL NC_011748.1 2022785 2023231 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2022785..2023231 Escherichia coli 55989 7144674 YP_002403016.1 CDS yeaM NC_011748.1 2023188 2024009 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(2023188..2024009) Escherichia coli 55989 7148527 YP_002403017.1 CDS yeaN NC_011748.1 2024106 2025287 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter; MFS superfamily 2024106..2025287 Escherichia coli 55989 7148528 YP_002403018.1 CDS yeaO NC_011748.1 2025342 2025689 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2025342..2025689 Escherichia coli 55989 7148529 YP_002403019.1 CDS yoaF NC_011748.1 2025711 2025965 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; outer membrane protein complement(2025711..2025965) Escherichia coli 55989 7148530 YP_002403020.1 CDS yeaP NC_011748.1 2026148 2027173 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; diguanylate cyclase 2026148..2027173 Escherichia coli 55989 7149338 YP_002403021.1 CDS yeaQ NC_011748.1 2027440 2027688 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(2027440..2027688) Escherichia coli 55989 7148531 YP_002403022.1 CDS EC55989_1966 NC_011748.1 2027700 2027885 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2027700..2027885) Escherichia coli 55989 7148532 YP_002403023.1 CDS ydcM NC_011748.1 2027915 2029123 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase complement(2027915..2029123) Escherichia coli 55989 7144675 YP_002403024.1 CDS EC55989_1968 NC_011748.1 2029101 2029247 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2029101..2029247) Escherichia coli 55989 7148392 YP_002403025.1 CDS EC55989_1969 NC_011748.1 2029578 2029766 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2029578..2029766) Escherichia coli 55989 7144676 YP_002403026.1 CDS yeaR NC_011748.1 2029770 2030129 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2029770..2030129) Escherichia coli 55989 7144677 YP_002403027.1 CDS yeaS NC_011748.1 2030302 2030940 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; leucine export protein LeuE complement(2030302..2030940) Escherichia coli 55989 7148533 YP_002403028.1 CDS yeaT NC_011748.1 2031067 2031990 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(2031067..2031990) Escherichia coli 55989 7148534 YP_002403029.1 CDS yeaU NC_011748.1 2032093 2033178 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; tartrate dehydrogenase 2032093..2033178 Escherichia coli 55989 7148535 YP_002403030.1 CDS yeaV NC_011748.1 2033594 2035039 D member of the betaine, carnitine, choline transporter (BCCT) family; unknown function; transporter 2033594..2035039 Escherichia coli 55989 7148536 YP_002403031.1 CDS yeaW NC_011748.1 2035071 2036195 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; 2Fe-2S cluster-containing dioxygenase subunit 2035071..2036195 Escherichia coli 55989 7148537 YP_002403032.1 CDS yeaX NC_011748.1 2036251 2037216 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; dioxygenase subunit 2036251..2037216 Escherichia coli 55989 7148538 YP_002403033.1 CDS rnd NC_011748.1 2037270 2038397 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88289400, 89053950, 93015723, 8107670; Product type e : enzyme; ribonuclease D complement(2037270..2038397) Escherichia coli 55989 7148539 YP_002403034.1 CDS fadD NC_011748.1 2038467 2040152 R Activates fatty acids by binding to coenzyme A; long-chain-fatty-acid--CoA ligase complement(2038467..2040152) Escherichia coli 55989 7147447 YP_002403035.1 CDS yeaY NC_011748.1 2040357 2040938 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type lp : lipoprotein; outer membrane-associated lipoprotein complement(2040357..2040938) Escherichia coli 55989 7146057 YP_002403036.1 CDS yeaZ NC_011748.1 2040978 2041673 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; peptidase complement(2040978..2041673) Escherichia coli 55989 7148540 YP_002403037.1 CDS yoaA NC_011748.1 2041731 2043641 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; ATP-dependent helicase complement(2041731..2043641) Escherichia coli 55989 7148541 YP_002403038.1 CDS yoaB NC_011748.1 2043773 2044117 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2043773..2044117 Escherichia coli 55989 7149334 YP_002403039.1 CDS yoaC NC_011748.1 2044480 2044839 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2044480..2044839 Escherichia coli 55989 7149335 YP_002403040.1 CDS yoaH NC_011748.1 2044959 2045138 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2044959..2045138) Escherichia coli 55989 7149336 YP_002403041.1 CDS pabB NC_011748.1 2045212 2046573 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88025006, 91067712, 91302313, 96011382, 6330050, 7896119; Product type e : enzyme; aminodeoxychorismate synthase subunit I 2045212..2046573 Escherichia coli 55989 7149339 YP_002403042.1 CDS yeaB NC_011748.1 2046577 2047155 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : enzyme; hypothetical protein 2046577..2047155 Escherichia coli 55989 7147107 YP_002403043.1 CDS sdaA NC_011748.1 2047339 2048703 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15155761, 89359152, 91056090, 93170282; Product type e : enzyme; L-serine deaminase I 2047339..2048703 Escherichia coli 55989 7148518 YP_002403044.1 CDS adrB NC_011748.1 2048834 2050432 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16513732; Product type pe : enzyme; cyclic di-GMP phosphodiesterase 2048834..2050432 Escherichia coli 55989 7147612 YP_002403045.1 CDS yoaE NC_011748.1 2050436 2051992 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; membrane protein fused with conserved domain complement(2050436..2051992) Escherichia coli 55989 7145461 YP_002403046.1 CDS manX NC_011748.1 2052455 2053426 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165962, 90036983, 8131846, 8676384, 9074635, 9298646; Product type t : transporter; fused mannose-specific PTS enzymes: IIA component ; IIB component 2052455..2053426 Escherichia coli 55989 7149337 YP_002403047.1 CDS manY NC_011748.1 2053489 2054289 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 87165962, 90036983, 94086520, 97128775, 7811395, 8774730; Product type t : transporter; mannose-specific enzyme IIC component of PTS 2053489..2054289 Escherichia coli 55989 7146782 YP_002403048.1 CDS manZ NC_011748.1 2054293 2055153 D hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel; PTS system mannose-specific transporter subunit IID 2054293..2055153 Escherichia coli 55989 7146783 YP_002403049.1 CDS yobD NC_011748.1 2055208 2055666 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2055208..2055666 Escherichia coli 55989 7146784 YP_002403050.1 CDS EC55989_1994 NC_011748.1 2055853 2056098 D Evidence 6 : Doubtful CDS; hypothetical protein 2055853..2056098 Escherichia coli 55989 7149342 YP_002403051.1 CDS yebN NC_011748.1 2056095 2056661 D membrane protein YebN; hypothetical protein 2056095..2056661 Escherichia coli 55989 7144678 YP_002403052.1 CDS rrmA NC_011748.1 2056658 2057467 R methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth; 23S rRNA methyltransferase complement(2056658..2057467) Escherichia coli 55989 7148549 YP_002403053.1 CDS cspC NC_011748.1 2057633 2057842 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 21101802, 94293754, 12071744, 7984109, 8022261, 9298646, 9868784, 9921691; Product type f : factor; cold shock-like protein CspC complement(2057633..2057842) Escherichia coli 55989 7147527 YP_002403054.1 CDS yobF NC_011748.1 2057855 2057998 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2057855..2057998) Escherichia coli 55989 7145778 YP_002403055.1 CDS yebO NC_011748.1 2058668 2058955 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2058668..2058955) Escherichia coli 55989 7149343 YP_002403056.1 CDS yobG NC_011748.1 2059030 2059173 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2059030..2059173) Escherichia coli 55989 7148550 YP_002403057.1 CDS yobH NC_011748.1 2059332 2059571 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2059332..2059571 Escherichia coli 55989 7149344 YP_002403058.1 CDS insA NC_011748.1 2059868 2060143 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 2059868..2060143 Escherichia coli 55989 7149345 YP_002403059.1 CDS insB NC_011748.1 2060062 2060565 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 2060062..2060565 Escherichia coli 55989 7146575 YP_002403060.1 CDS kdgR NC_011748.1 2060500 2061282 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659677, 4359651; Product type r : regulator; DNA-binding transcriptional repressor KdgR complement(2060500..2061282) Escherichia coli 55989 7146587 YP_002403061.1 CDS yebQ NC_011748.1 2061459 2062832 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter; MFS superfamily 2061459..2062832 Escherichia coli 55989 7146652 YP_002403062.1 CDS htpX NC_011748.1 2062878 2063759 R metalloprotease; heat shock protein HtpX complement(2062878..2063759) Escherichia coli 55989 7148551 YP_002403063.1 CDS prc NC_011748.1 2063951 2065999 R Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3; carboxy-terminal protease complement(2063951..2065999) Escherichia coli 55989 7146474 YP_002403064.1 CDS proQ NC_011748.1 2066019 2066717 R affects solute and DNA transport through an unknown mechanism; solute/DNA competence effector complement(2066019..2066717) Escherichia coli 55989 7147239 YP_002403065.1 CDS yebR NC_011748.1 2066814 2067365 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2066814..2067365) Escherichia coli 55989 7147256 YP_002403066.1 CDS yebS NC_011748.1 2067441 2068724 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2067441..2068724 Escherichia coli 55989 7148552 YP_002403067.1 CDS yebT NC_011748.1 2068693 2071326 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2068693..2071326 Escherichia coli 55989 7148553 YP_002403068.1 CDS yebU NC_011748.1 2071406 2072845 D in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA; rRNA (cytosine-C(5)-)-methyltransferase RsmF 2071406..2072845 Escherichia coli 55989 7148554 YP_002403069.1 CDS yebV NC_011748.1 2072963 2073199 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2072963..2073199 Escherichia coli 55989 7148555 YP_002403070.1 CDS yebW NC_011748.1 2073220 2073495 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2073220..2073495 Escherichia coli 55989 7148556 YP_002403071.1 CDS pphA NC_011748.1 2073496 2074152 R Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins; serine/threonine protein phosphatase 1 complement(2073496..2074152) Escherichia coli 55989 7148557 YP_002403072.1 CDS yebY NC_011748.1 2074548 2074889 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2074548..2074889) Escherichia coli 55989 7144679 YP_002403073.1 CDS yebZ NC_011748.1 2074902 2075774 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(2074902..2075774) Escherichia coli 55989 7148558 YP_002403074.1 CDS yobA NC_011748.1 2075778 2076152 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2075778..2076152) Escherichia coli 55989 7148559 YP_002403075.1 CDS holE NC_011748.1 2076291 2076521 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15090519, 92147649, 92156151, 94131961, 1575709, 8341603, 8505306; Product type e : enzyme; DNA polymerase III subunit theta 2076291..2076521 Escherichia coli 55989 7149340 YP_002403076.1 CDS yobB NC_011748.1 2076623 2077279 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2076623..2077279 Escherichia coli 55989 7146457 YP_002403077.1 CDS exoX NC_011748.1 2077303 2077965 D 3'-5' exonuclease activity on single or double-strand DNA; exodeoxyribonuclease X 2077303..2077965 Escherichia coli 55989 7149341 YP_002403078.1 CDS ptrB NC_011748.1 2077962 2080022 R PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues; protease 2 complement(2077962..2080022) Escherichia coli 55989 7146043 YP_002403079.1 CDS yebE NC_011748.1 2080231 2080890 R Evidence 4 : Homologs of previously reported genes of unknown function; inner membrane protein complement(2080231..2080890) Escherichia coli 55989 7147284 YP_002403080.1 CDS yebF NC_011748.1 2081217 2081585 R secreted protein; unknown function; hypothetical protein complement(2081217..2081585) Escherichia coli 55989 7148545 YP_002403081.1 CDS yebG NC_011748.1 2081640 2081930 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9368369, 99403401; Product type cp : cell process; DNA damage-inducible protein YebG complement(2081640..2081930) Escherichia coli 55989 7148546 YP_002403082.1 CDS purT NC_011748.1 2082064 2083242 D non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis; phosphoribosylglycinamide formyltransferase 2 2082064..2083242 Escherichia coli 55989 7148547 YP_002403083.1 CDS eda NC_011748.1 2083298 2083939 R catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate; keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase complement(2083298..2083939) Escherichia coli 55989 7147304 YP_002403084.1 CDS edd NC_011748.1 2083976 2085787 R catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate; phosphogluconate dehydratase complement(2083976..2085787) Escherichia coli 55989 7145976 YP_002403085.1 CDS zwf NC_011748.1 2086022 2087497 R catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate; glucose-6-phosphate 1-dehydrogenase complement(2086022..2087497) Escherichia coli 55989 7145977 YP_002403086.1 CDS yebK NC_011748.1 2087835 2088704 D Represses the expression of the zwf, eda, glp and gap; DNA-binding transcriptional regulator HexR 2087835..2088704 Escherichia coli 55989 7149500 YP_002403087.1 CDS pykA NC_011748.1 2088832 2090274 D catalyzes the formation of phosphoenolpyruvate from pyruvate; pyruvate kinase 2088832..2090274 Escherichia coli 55989 7148548 YP_002403088.1 CDS lpxM NC_011748.1 2090405 2091376 R Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase complement(2090405..2091376) Escherichia coli 55989 7147315 YP_002403089.1 CDS yebA NC_011748.1 2091496 2092818 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1732206; Product type pe : enzyme; hypothetical protein complement(2091496..2092818) Escherichia coli 55989 7146742 YP_002403090.1 CDS znuA NC_011748.1 2092834 2093766 R involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter periplasmic protein complement(2092834..2093766) Escherichia coli 55989 7148542 YP_002403091.1 CDS znuC NC_011748.1 2093845 2094600 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter ATPase 2093845..2094600 Escherichia coli 55989 7149492 YP_002403092.1 CDS znuB NC_011748.1 2094597 2095382 D involved in transport of zinc(II) with ZnuA and C; high-affinity zinc transporter membrane protein 2094597..2095382 Escherichia coli 55989 7149494 YP_002403093.1 CDS ruvB NC_011748.1 2095529 2096539 R promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration; Holliday junction DNA helicase RuvB complement(2095529..2096539) Escherichia coli 55989 7149493 YP_002403094.1 CDS ruvA NC_011748.1 2096548 2097159 R plays an essential role in ATP-dependent branch migration of the Holliday junction; Holliday junction DNA helicase RuvA complement(2096548..2097159) Escherichia coli 55989 7147570 YP_002403095.1 CDS yebB NC_011748.1 2097434 2098036 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2097434..2098036 Escherichia coli 55989 7147569 YP_002403096.1 CDS ruvC NC_011748.1 2098038 2098559 R endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity; Holliday junction resolvase complement(2098038..2098559) Escherichia coli 55989 7148543 YP_002403097.1 CDS yebC NC_011748.1 2098594 2099334 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2098594..2099334) Escherichia coli 55989 7147571 YP_002403098.1 CDS ntpA NC_011748.1 2099363 2099806 R converts dATP to dAMP and pyrophosphate; dATP pyrophosphohydrolase complement(2099363..2099806) Escherichia coli 55989 7148544 YP_002403099.1 CDS aspS NC_011748.1 2099808 2101580 R catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes; aspartyl-tRNA synthetase complement(2099808..2101580) Escherichia coli 55989 7147036 YP_002403100.1 CDS yecD NC_011748.1 2101890 2102456 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 2101890..2102456 Escherichia coli 55989 7145573 YP_002403101.1 CDS yecE NC_011748.1 2102453 2103271 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2129559, 7984428; hypothetical protein 2102453..2103271 Escherichia coli 55989 7148562 YP_002403102.1 CDS yecN NC_011748.1 2103324 2103719 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2103324..2103719 Escherichia coli 55989 7148563 YP_002403103.1 CDS yecO NC_011748.1 2103760 2104503 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11746687; Product type e : enzyme; AdoMet-dependent methyltransferase 2103760..2104503 Escherichia coli 55989 7148570 YP_002403104.1 CDS yecP NC_011748.1 2104500 2105471 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2104500..2105471 Escherichia coli 55989 7148571 YP_002403105.1 CDS torZ NC_011748.1 2105636 2108065 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 97077292, 11004177; Product type e : enzyme; trimethylamine N-oxide reductase system III, catalytic subunit complement(2105636..2108065) Escherichia coli 55989 7148572 YP_002403106.1 CDS torY NC_011748.1 2108090 2109190 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461225, 8919859; Product type c : carrier; TMAO reductase III (TorYZ), cytochrome c-type subunit complement(2108090..2109190) Escherichia coli 55989 7147828 YP_002403107.1 CDS cutC NC_011748.1 2109578 2110324 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95362641, 7635807; Product type t : transporter; copper homeostasis protein CutC complement(2109578..2110324) Escherichia coli 55989 7147827 YP_002403108.1 CDS yecM NC_011748.1 2110338 2110904 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12660999; Product type pe : enzyme; hypothetical protein complement(2110338..2110904) Escherichia coli 55989 7145799 YP_002403109.1 CDS argS NC_011748.1 2111120 2112853 D catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase; arginyl-tRNA synthetase 2111120..2112853 Escherichia coli 55989 7148569 YP_002403110.1 CDS yecT NC_011748.1 2113030 2113518 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2113030..2113518 Escherichia coli 55989 7145536 YP_002403111.1 CDS flhE NC_011748.1 2113638 2114030 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8002587, 1482109, 89181349; hypothetical protein complement(2113638..2114030) Escherichia coli 55989 7148575 YP_002403112.1 CDS flhA NC_011748.1 2114030 2116108 R membrane protein involved in the flagellar export apparatus; flagellar biosynthesis protein FlhA complement(2114030..2116108) Escherichia coli 55989 7146142 YP_002403113.1 CDS flhB NC_011748.1 2116101 2117249 R membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export; flagellar biosynthesis protein FlhB complement(2116101..2117249) Escherichia coli 55989 7146138 YP_002403114.1 CDS cheZ NC_011748.1 2117451 2118095 R cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation; chemotaxis regulator CheZ complement(2117451..2118095) Escherichia coli 55989 7146139 YP_002403115.1 CDS cheY NC_011748.1 2118106 2118495 R chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble; chemotaxis regulatory protein CheY complement(2118106..2118495) Escherichia coli 55989 7145702 YP_002403116.1 CDS cheB NC_011748.1 2118510 2119559 R regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins; chemotaxis-specific methylesterase complement(2118510..2119559) Escherichia coli 55989 7145701 YP_002403117.1 CDS cheR NC_011748.1 2119562 2120422 R methylates the MCP; chemotaxis methyltransferase CheR complement(2119562..2120422) Escherichia coli 55989 7145698 YP_002403118.1 CDS tap NC_011748.1 2120441 2122042 R mediates taxis toward dipeptides; methyl-accepting protein IV complement(2120441..2122042) Escherichia coli 55989 7145699 YP_002403119.1 CDS tar NC_011748.1 2122088 2123749 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90094243, 92165727, 6305515, 9315712; Product type r : regulator; methyl-accepting chemotaxis protein II complement(2122088..2123749) Escherichia coli 55989 7147750 YP_002403120.1 CDS cheW NC_011748.1 2123894 2124397 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91126073, 91296802, 91317710, 2002011, 3510184; Product type r : regulator; purine-binding chemotaxis protein complement(2123894..2124397) Escherichia coli 55989 7145650 YP_002403121.1 CDS cheA NC_011748.1 2124418 2126382 R chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component; chemotaxis protein CheA complement(2124418..2126382) Escherichia coli 55989 7145700 YP_002403122.1 CDS motB NC_011748.1 2126387 2127313 R with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotB complement(2126387..2127313) Escherichia coli 55989 7145697 YP_002403123.1 CDS motA NC_011748.1 2127310 2128197 R With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine; flagellar motor protein MotA complement(2127310..2128197) Escherichia coli 55989 7146889 YP_002403124.1 CDS flhC NC_011748.1 2128324 2128902 R With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems; transcriptional activator FlhC complement(2128324..2128902) Escherichia coli 55989 7146888 YP_002403125.1 CDS flhD NC_011748.1 2128905 2129264 R with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems; transcriptional activator FlhD complement(2128905..2129264) Escherichia coli 55989 7146140 YP_002403126.1 CDS yecG NC_011748.1 2130034 2130462 D ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspC 2130034..2130462 Escherichia coli 55989 7146141 YP_002403127.1 CDS otsA NC_011748.1 2130469 2131893 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92078100, 92121128, 93302496, 8045430; Product type e : enzyme; trehalose-6-phosphate synthase complement(2130469..2131893) Escherichia coli 55989 7148565 YP_002403128.1 CDS otsB NC_011748.1 2131868 2132668 R biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature; trehalose-6-phosphate phosphatase complement(2131868..2132668) Escherichia coli 55989 7147085 YP_002403129.1 CDS araH NC_011748.1 2132835 2133824 R Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter permease complement(2132835..2133824) Escherichia coli 55989 7147086 YP_002403130.1 CDS araG NC_011748.1 2133836 2135350 R Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose; L-arabinose transporter ATP-binding protein complement(2133836..2135350) Escherichia coli 55989 7145520 YP_002403131.1 CDS araF NC_011748.1 2135420 2136409 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89255061, 90375534, 2445996, 326784, 326785, 6885805, 7031057, 9298646; Product type t : transporter; L-arabinose transporter subunit ; periplasmic-binding component of ABC superfamily complement(2135420..2136409) Escherichia coli 55989 7145519 YP_002403132.1 CDS yecI NC_011748.1 2137206 2137709 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; ferritin-like protein 2137206..2137709 Escherichia coli 55989 7145518 YP_002403133.1 CDS yecJ NC_011748.1 2137788 2138039 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2137788..2138039) Escherichia coli 55989 7148567 YP_002403134.1 CDS EC55989_2080 NC_011748.1 2138151 2138297 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2138151..2138297 Escherichia coli 55989 7146634 YP_002403135.1 CDS yecR NC_011748.1 2138503 2138826 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2138503..2138826 Escherichia coli 55989 7144680 YP_002403136.1 CDS ftn NC_011748.1 2138998 2139495 D cytoplasmic iron storage protein; ferritin 2138998..2139495 Escherichia coli 55989 7148573 YP_002403137.1 CDS yecH NC_011748.1 2139533 2139772 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2139533..2139772) Escherichia coli 55989 7146209 YP_002403138.1 CDS tyrP NC_011748.1 2139962 2141173 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89008121, 2022620; Product type t : transporter; tyrosine transporter 2139962..2141173 Escherichia coli 55989 7148566 YP_002403139.1 CDS yecA NC_011748.1 2141235 2141900 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2141235..2141900) Escherichia coli 55989 7147883 YP_002403140.1 CDS int NC_011748.1 2142257 2143258 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Integrase complement(2142257..2143258) Escherichia coli 55989 7148560 YP_002403141.1 CDS EC55989_2087 NC_011748.1 2143264 2143611 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2143264..2143611) Escherichia coli 55989 7146603 YP_002403142.1 CDS EC55989_2088 NC_011748.1 2143641 2144291 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2143641..2144291) Escherichia coli 55989 7144681 YP_002403143.1 CDS EC55989_2089 NC_011748.1 2144307 2144711 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; regulator complement(2144307..2144711) Escherichia coli 55989 7144682 YP_002403144.1 CDS EC55989_2090 NC_011748.1 2144787 2144993 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2144787..2144993 Escherichia coli 55989 7144683 YP_002403145.1 CDS EC55989_2091 NC_011748.1 2145010 2145213 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage regulator DNA-binding protein) 2145010..2145213 Escherichia coli 55989 7144684 YP_002403146.1 CDS EC55989_2092 NC_011748.1 2145425 2145586 D Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; hypothetical protein 2145425..2145586 Escherichia coli 55989 7144685 YP_002403147.1 CDS EC55989_2093 NC_011748.1 2145537 2145875 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2145537..2145875 Escherichia coli 55989 7144686 YP_002403148.1 CDS EC55989_2094 NC_011748.1 2145884 2146129 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2145884..2146129 Escherichia coli 55989 7144687 YP_002403149.1 CDS EC55989_2095 NC_011748.1 2146275 2146529 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2146275..2146529 Escherichia coli 55989 7144688 YP_002403150.1 CDS EC55989_2096 NC_011748.1 2146469 2146771 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2146469..2146771 Escherichia coli 55989 7144689 YP_002403151.1 CDS EC55989_2097 NC_011748.1 2146913 2147278 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2146913..2147278 Escherichia coli 55989 7144690 YP_002403152.1 CDS EC55989_2098 NC_011748.1 2147285 2150107 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage replication protein 2147285..2150107 Escherichia coli 55989 7144691 YP_002403153.1 CDS parM NC_011748.1 2150184 2151143 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Plasmid segregation protein parM (Protein stbA) (ParA locus 36 kDa protein) 2150184..2151143 Escherichia coli 55989 7144692 YP_002403154.1 CDS EC55989_2100 NC_011748.1 2151148 2151462 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; stability/partitioning protein phage encoded ( plasmid partition protein) (modular protein) 2151148..2151462 Escherichia coli 55989 7147117 YP_002403155.1 CDS EC55989_2101 NC_011748.1 2151482 2151913 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2151482..2151913 Escherichia coli 55989 7144693 YP_002403156.1 CDS EC55989_2102 NC_011748.1 2151894 2152178 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2151894..2152178 Escherichia coli 55989 7144694 YP_002403157.1 CDS EC55989_2103 NC_011748.1 2152201 2152587 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2152201..2152587) Escherichia coli 55989 7144695 YP_002403158.1 CDS Q NC_011748.1 2152690 2153736 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; portal capsid protein Q (GpQ) complement(2152690..2153736) Escherichia coli 55989 7144696 YP_002403159.1 CDS P NC_011748.1 2153736 2155487 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Terminase, ATPase subunit (GpP) complement(2153736..2155487) Escherichia coli 55989 7147327 YP_002403160.1 CDS O NC_011748.1 2155609 2156478 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Capsid scaffolding protein O 2155609..2156478 Escherichia coli 55989 7147090 YP_002403161.1 CDS N NC_011748.1 2156502 2157554 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major capsid protein precursor (GpN) 2156502..2157554 Escherichia coli 55989 7147061 YP_002403162.1 CDS M NC_011748.1 2157600 2158400 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Phage terminase, endonuclease small subunit M 2157600..2158400 Escherichia coli 55989 7146939 YP_002403163.1 CDS L NC_011748.1 2158432 2158998 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Head completion/stabilization protein L 2158432..2158998 Escherichia coli 55989 7146762 YP_002403164.1 CDS EC55989_2111 NC_011748.1 2158982 2159524 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2158982..2159524 Escherichia coli 55989 7146674 YP_002403165.1 CDS X NC_011748.1 2158998 2159198 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail protein X (GpX) 2158998..2159198 Escherichia coli 55989 7144697 YP_002403166.1 CDS EC55989_2112 NC_011748.1 2159521 2159913 D hypothetical protein 2159521..2159913 Escherichia coli 55989 7147981 YP_002403167.1 CDS EC55989_2113 NC_011748.1 2159766 2160317 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2159766..2160317 Escherichia coli 55989 7144698 YP_002403168.1 CDS EC55989_2114 NC_011748.1 2160456 2162336 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2160456..2162336 Escherichia coli 55989 7144699 YP_002403169.1 CDS R NC_011748.1 2162360 2162827 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Phage tail completion protein R 2162360..2162827 Escherichia coli 55989 7144700 YP_002403170.1 CDS S NC_011748.1 2162811 2163455 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage tail protein S 2162811..2163455 Escherichia coli 55989 7147334 YP_002403171.1 CDS V NC_011748.1 2163452 2164033 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; baseplate assembly protein V 2163452..2164033 Escherichia coli 55989 7147599 YP_002403172.1 CDS W NC_011748.1 2164030 2164380 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein W 2164030..2164380 Escherichia coli 55989 7147944 YP_002403173.1 CDS J NC_011748.1 2164384 2165280 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Baseplate assembly protein J 2164384..2165280 Escherichia coli 55989 7147955 YP_002403174.1 CDS I NC_011748.1 2165273 2165881 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Tail protein I 2165273..2165881 Escherichia coli 55989 7146644 YP_002403175.1 CDS tfaQ NC_011748.1 2167893 2168471 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; tail fiber chaperone; Qin prophage 2167893..2168471 Escherichia coli 55989 7144701 YP_002403176.1 CDS EC55989_2123 NC_011748.1 2168515 2169120 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; serine acetlyltransferase from phage complement(2168515..2169120) Escherichia coli 55989 7147780 YP_002403177.1 CDS EC55989_2124 NC_011748.1 2169244 2169738 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail fiber protein complement(2169244..2169738) Escherichia coli 55989 7144702 YP_002403178.1 CDS EC55989_2125 NC_011748.1 2169745 2172561 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; tail protein (modular protein) complement(2169745..2172561) Escherichia coli 55989 7144703 YP_002403179.1 CDS EC55989_2126 NC_011748.1 2172539 2172775 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage tail protein E' complement(2172539..2172775) Escherichia coli 55989 7144704 YP_002403180.1 CDS EC55989_2127 NC_011748.1 2172703 2173077 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage tail protein E complement(2172703..2173077) Escherichia coli 55989 7144705 YP_002403181.1 CDS fII NC_011748.1 2173133 2173645 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail tube protein FII complement(2173133..2173645) Escherichia coli 55989 7144706 YP_002403182.1 CDS fI NC_011748.1 2173645 2174829 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major tail sheath protein FI complement(2173645..2174829) Escherichia coli 55989 7146110 YP_002403183.1 CDS D NC_011748.1 2174855 2176096 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Gene late control D protein 2174855..2176096 Escherichia coli 55989 7146106 YP_002403184.1 CDS EC55989_2131 NC_011748.1 2176920 2177315 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2176920..2177315) Escherichia coli 55989 7145840 YP_002403185.1 CDS pgsA NC_011748.1 2178194 2178742 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 381294, 7007311, 94253011, 1323047, 3003065, 8917447; Product type e : enzyme; phosphatidylglycerophosphate synthetase complement(2178194..2178742) Escherichia coli 55989 7145392 YP_002403186.1 CDS uvrC NC_011748.1 2178799 2180631 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision; excinuclease ABC subunit C complement(2178799..2180631) Escherichia coli 55989 7147156 YP_002403187.1 CDS uvrY NC_011748.1 2180628 2181284 R in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system; response regulator complement(2180628..2181284) Escherichia coli 55989 7147935 YP_002403188.1 CDS EC55989_2135 NC_011748.1 2181580 2181756 D Evidence 6 : Doubtful CDS; hypothetical protein 2181580..2181756 Escherichia coli 55989 7147937 YP_002403189.1 CDS yecF NC_011748.1 2181743 2181967 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3515318, 7567469; hypothetical protein 2181743..2181967 Escherichia coli 55989 7144708 YP_002403190.1 CDS sdiA NC_011748.1 2182035 2182757 R regulates genes involved in cell division; DNA-binding transcriptional activator SdiA complement(2182035..2182757) Escherichia coli 55989 7148564 YP_002403191.1 CDS yecC NC_011748.1 2182987 2183739 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; amino-acid ABC transporter ATP-binding protein YecC complement(2182987..2183739) Escherichia coli 55989 7147619 YP_002403192.1 CDS yecS NC_011748.1 2183736 2184404 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: permease component of ABC superfamily transporter complement(2183736..2184404) Escherichia coli 55989 7148561 YP_002403193.1 CDS yedO NC_011748.1 2184419 2185405 R catalyzes the formation of pyruvate from D-cysteine; D-cysteine desulfhydrase complement(2184419..2185405) Escherichia coli 55989 7148574 YP_002403194.1 CDS fliY NC_011748.1 2185510 2186310 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125225, 8450713, 8774726, 9298646, 9740056; Product type t : transporter; cystine transporter subunit complement(2185510..2186310) Escherichia coli 55989 7148583 YP_002403195.1 CDS fliZ NC_011748.1 2186398 2186949 R expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence; flagella biosynthesis protein FliZ complement(2186398..2186949) Escherichia coli 55989 7146160 YP_002403196.1 CDS fliA NC_011748.1 2186995 2187714 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes; flagellar biosynthesis sigma factor complement(2186995..2187714) Escherichia coli 55989 7146161 YP_002403197.1 CDS EC55989_2144 NC_011748.1 2187878 2188927 R Evidence 2b : Function of strongly homologous gene; Product type ps : structure; Flagellin complement(2187878..2188927) Escherichia coli 55989 7146143 YP_002403198.1 CDS fliD NC_011748.1 2189175 2190590 D involved in flagellin assembly; flagellar capping protein 2189175..2190590 Escherichia coli 55989 7144709 YP_002403199.1 CDS fliS NC_011748.1 2190606 2191016 D flagellin specific chaperone; flagellar protein FliS 2190606..2191016 Escherichia coli 55989 7144710 YP_002403200.1 CDS fliT NC_011748.1 2191016 2191381 D binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family; flagellar biosynthesis protein FliT 2191016..2191381 Escherichia coli 55989 7146158 YP_002403201.1 CDS amyA NC_011748.1 2191459 2192946 D converts 1,4-alpha-D-glucans to maltodextrin; alpha-amylase 2191459..2192946 Escherichia coli 55989 7146159 YP_002403202.1 CDS yedD NC_011748.1 2192980 2193393 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2192980..2193393) Escherichia coli 55989 7145500 YP_002403203.1 CDS yedE NC_011748.1 2193580 2194785 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2193580..2194785 Escherichia coli 55989 7148577 YP_002403204.1 CDS yedF NC_011748.1 2194782 2195015 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2194782..2195015 Escherichia coli 55989 7148578 YP_002403205.1 CDS EC55989_2153 NC_011748.1 2195810 2196379 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase ORF A, IS609 family 2195810..2196379 Escherichia coli 55989 7148582 YP_002403206.1 CDS ybcM NC_011748.1 2196536 2197333 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12270809; Product type pr : regulator; DNA-binding transcriptional regulator; DLP12 prophage complement(2196536..2197333) Escherichia coli 55989 7144711 YP_002403207.1 CDS ybcL NC_011748.1 2197343 2197894 R DLP12 prophage; similar to PEBP/RK1P protein family in eukaryotes that inhibits MEK phosphorylation by Raf-1; crystal structure suggests similar properties but exact function is unknown; kinase inhibitor complement(2197343..2197894) Escherichia coli 55989 7148131 YP_002403208.1 CDS emrE NC_011748.1 2198063 2198575 R member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation; multidrug efflux protein complement(2198063..2198575) Escherichia coli 55989 7148130 YP_002403209.1 CDS fliE NC_011748.1 2198739 2199053 R forms a junction between the M-ring and FlgB during flagella biosynthesis; flagellar hook-basal body protein FliE complement(2198739..2199053) Escherichia coli 55989 7145993 YP_002403210.1 CDS fliF NC_011748.1 2199268 2200926 D the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod; flagellar MS-ring protein 2199268..2200926 Escherichia coli 55989 7146144 YP_002403211.1 CDS fliG NC_011748.1 2200919 2201914 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein G 2200919..2201914 Escherichia coli 55989 7146145 YP_002403212.1 CDS fliH NC_011748.1 2201907 2202593 D binds to and inhibits the function of flagella specific ATPase FliI; flagellar assembly protein H 2201907..2202593 Escherichia coli 55989 7146146 YP_002403213.1 CDS fliI NC_011748.1 2202593 2203966 D involved in type III protein export during flagellum assembly; flagellum-specific ATP synthase 2202593..2203966 Escherichia coli 55989 7146147 YP_002403214.1 CDS fliJ NC_011748.1 2203985 2204428 D rod/hook and filament chaperone; flagellar biosynthesis chaperone 2203985..2204428 Escherichia coli 55989 7146148 YP_002403215.1 CDS fliK NC_011748.1 2204425 2205552 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1482109, 8631687; Product type s : structure; flagellar hook-length control protein 2204425..2205552 Escherichia coli 55989 7146149 YP_002403216.1 CDS fliL NC_011748.1 2205657 2206121 D interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring; flagellar basal body-associated protein FliL 2205657..2206121 Escherichia coli 55989 7146150 YP_002403217.1 CDS fliM NC_011748.1 2206126 2207130 D with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation; flagellar motor switch protein FliM 2206126..2207130 Escherichia coli 55989 7146151 YP_002403218.1 CDS fliN NC_011748.1 2207127 2207540 D One of three proteins involved in switching the direction of the flagellar rotation; flagellar motor switch protein FliN 2207127..2207540 Escherichia coli 55989 7146152 YP_002403219.1 CDS fliO NC_011748.1 2207543 2207908 D with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus; flagellar biosynthesis protein FliO 2207543..2207908 Escherichia coli 55989 7146153 YP_002403220.1 CDS fliP NC_011748.1 2207908 2208645 D FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliP 2207908..2208645 Escherichia coli 55989 7146154 YP_002403221.1 CDS fliQ NC_011748.1 2208655 2208924 D with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliQ 2208655..2208924 Escherichia coli 55989 7146155 YP_002403222.1 CDS fliR NC_011748.1 2208933 2209718 D FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus; flagellar biosynthesis protein FliR 2208933..2209718 Escherichia coli 55989 7146156 YP_002403223.1 CDS rcsA NC_011748.1 2210008 2210631 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14514676, 14766922, 20167175, 90130299, 91154130, 92048476, 9882673, 7534408; Product type r : regulator; DNA-binding transcriptional activator, co-regulator with RcsB 2210008..2210631 Escherichia coli 55989 7146157 YP_002403224.1 CDS dsrB NC_011748.1 2210675 2210863 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96324407, 7534408; hypothetical protein complement(2210675..2210863) Escherichia coli 55989 7147347 YP_002403225.1 CDS yodD NC_011748.1 2211026 2211253 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2211026..2211253 Escherichia coli 55989 7145958 YP_002403226.1 CDS yedP NC_011748.1 2211552 2212367 D catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate; mannosyl-3-phosphoglycerate phosphatase 2211552..2212367 Escherichia coli 55989 7145956 YP_002403227.1 CDS EC55989_2177 NC_011748.1 2213979 2214167 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2213979..2214167) Escherichia coli 55989 7148586 YP_002403228.1 CDS yodC NC_011748.1 2214229 2214411 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2214229..2214411) Escherichia coli 55989 7144712 YP_002403229.1 CDS yedI NC_011748.1 2214490 2215407 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(2214490..2215407) Escherichia coli 55989 7149347 YP_002403230.1 CDS yedA NC_011748.1 2215580 2216500 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2215580..2216500 Escherichia coli 55989 7148580 YP_002403231.1 CDS vsr NC_011748.1 2216489 2216959 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90330522, 92049708, 94049122, 10360178, 10612397, 10871403, 2527357; Product type e : enzyme; DNA mismatch endonuclease of very short patch repair complement(2216489..2216959) Escherichia coli 55989 7148576 YP_002403232.1 CDS dcm NC_011748.1 2216940 2218358 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90280700, 91285397, 93367813, 2198248, 2527357; Product type e : enzyme; DNA cytosine methylase complement(2216940..2218358) Escherichia coli 55989 7147953 YP_002403233.1 CDS yedJ NC_011748.1 2218425 2219120 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7567469; Product type pe : enzyme; hypothetical protein complement(2218425..2219120) Escherichia coli 55989 7145856 YP_002403234.1 CDS yedR NC_011748.1 2219160 2219525 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(2219160..2219525) Escherichia coli 55989 7148581 YP_002403235.1 CDS insI NC_011748.1 2221472 2222623 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094, 6092059; Product type e : enzyme; IS30 transposase; KpLE2 phage-like element complement(2221472..2222623) Escherichia coli 55989 7146599 YP_002403236.1 CDS EC55989_2189 NC_011748.1 2222763 2223581 D Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase ORF B, IS600 2222763..2223581 Escherichia coli 55989 7147434 YP_002403237.1 CDS insB NC_011748.1 2224087 2224590 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' complement(2224087..2224590) Escherichia coli 55989 7144715 YP_002403238.1 CDS insA NC_011748.1 2224509 2224784 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(2224509..2224784) Escherichia coli 55989 7146588 YP_002403239.1 CDS hchA NC_011748.1 2224870 2225721 D Hsp31 stabilizes early unfolding protein intermediates under severe heat stress; chaperone protein HchA 2224870..2225721 Escherichia coli 55989 7146576 YP_002403240.1 CDS yedV NC_011748.1 2225819 2227177 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865; Product type rc : receptor; sensory kinase in two-component regulatory system with YedW complement(2225819..2227177) Escherichia coli 55989 7146397 YP_002403241.1 CDS yedW NC_011748.1 2227177 2227848 R induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced; transcriptional regulatory protein YedW complement(2227177..2227848) Escherichia coli 55989 7148588 YP_002403242.1 CDS yedX NC_011748.1 2227981 2228394 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2227981..2228394 Escherichia coli 55989 7148589 YP_002403243.1 CDS yedY NC_011748.1 2228503 2229507 D in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ; sulfite oxidase subunit YedY 2228503..2229507 Escherichia coli 55989 7148590 YP_002403244.1 CDS yedZ NC_011748.1 2229508 2230143 D in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme; sulfite oxidase subunit YedZ 2229508..2230143 Escherichia coli 55989 7148591 YP_002403245.1 CDS yodA NC_011748.1 2230400 2231050 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12077457, 12480884, 12909634, 9579078; hypothetical protein 2230400..2231050 Escherichia coli 55989 7148592 YP_002403246.1 CDS yeeI NC_011748.1 2231903 2232700 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2231903..2232700 Escherichia coli 55989 7145391 YP_002403247.1 CDS int NC_011748.1 2233038 2234300 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; integrase 2233038..2234300 Escherichia coli 55989 7145331 YP_002403248.1 CDS irp NC_011748.1 2234494 2235798 R catalyzes the conversion of chorismate to salicylate in the biosynthesis of the siderophore yersiniabactin; salicylate synthase Irp9 complement(2234494..2235798) Escherichia coli 55989 7146604 YP_002403249.1 CDS irp NC_011748.1 2235826 2237229 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; yersiniabactin-iron transporter permease YbtX complement(2235826..2237229) Escherichia coli 55989 7146611 YP_002403250.1 CDS irp NC_011748.1 2237099 2238928 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10231486, 11320115; Product type t : transporter; permease and ATP-binding protein of yersiniabactin-iron ABC transporter YbtQ complement(2237099..2238928) Escherichia coli 55989 7146612 YP_002403251.1 CDS irp NC_011748.1 2238888 2240690 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10231486, 11320115; Product type t : transporter; permease and ATP-binding protein of yersiniabactin-iron ABC transporter YbtP complement(2238888..2240690) Escherichia coli 55989 7146613 YP_002403252.1 CDS ybtA NC_011748.1 2240857 2241816 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8930916; Product type r : regulator; AraC family transcriptional regulator 2240857..2241816 Escherichia coli 55989 7146614 YP_002403253.1 CDS irp NC_011748.1 2241989 2248114 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15719346, 15582399, 8366034, 11927258, 9709002; Product type e : enzyme; High-molecular-weight nonribosomal peptide/polyketide synthetase 2 (HMWP2) 2241989..2248114 Escherichia coli 55989 7148239 YP_002403254.1 CDS irp NC_011748.1 2248202 2257693 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15719346, 15582399, 11927258; Product type e : enzyme; High-molecular-weight nonribosomal peptide/polyketide synthetase 1 (HMWP1) 2248202..2257693 Escherichia coli 55989 7146615 YP_002403255.1 CDS irp NC_011748.1 2257630 2258790 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11927258; Product type e : enzyme; Thiazolinyl-S-HMWP1 reductase YbtU 2257630..2258790 Escherichia coli 55989 7146616 YP_002403256.1 CDS irp NC_011748.1 2258787 2259590 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; thioesterase YbtT 2258787..2259590 Escherichia coli 55989 7146617 YP_002403257.1 CDS irp NC_011748.1 2259594 2261171 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 9818149, 11927258, 9709002; Product type e : enzyme; salicyl-AMP ligase YbtE 2259594..2261171 Escherichia coli 55989 7146618 YP_002403258.1 CDS fyuA NC_011748.1 2261302 2263323 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 7896707, 7984105; Product type rc : receptor; Yersiniabactin/pesticin outer membrane receptor (IRPC) 2261302..2263323 Escherichia coli 55989 7146619 YP_002403259.1 CDS EC55989_2217 NC_011748.1 2266942 2268057 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2266942..2268057) Escherichia coli 55989 7148601 YP_002403260.1 CDS shiA NC_011748.1 2268309 2269625 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 5332864, 9524262; Product type t : transporter; shikimate transporter 2268309..2269625 Escherichia coli 55989 7144716 YP_002403261.1 CDS amn NC_011748.1 2269727 2271181 D Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile; AMP nucleosidase 2269727..2271181 Escherichia coli 55989 7147653 YP_002403262.1 CDS yeeN NC_011748.1 2271524 2272240 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2271524..2272240 Escherichia coli 55989 7145493 YP_002403263.1 CDS yeeO NC_011748.1 2272868 2274508 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16042411; Product type pt : transporter; hypothetical protein complement(2272868..2274508) Escherichia coli 55989 7145390 YP_002403264.1 CDS cbl NC_011748.1 2274629 2275579 R LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB; transcriptional regulator Cbl complement(2274629..2275579) Escherichia coli 55989 7145332 YP_002403265.1 CDS nac NC_011748.1 2275681 2276598 R Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation; nitrogen assimilation transcriptional regulator complement(2275681..2276598) Escherichia coli 55989 7145666 YP_002403266.1 CDS erfK NC_011748.1 2277056 2277988 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein complement(2277056..2277988) Escherichia coli 55989 7145333 YP_002403267.1 CDS cobT NC_011748.1 2278053 2279132 R catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole; nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase complement(2278053..2279132) Escherichia coli 55989 7146022 YP_002403268.1 CDS cobS NC_011748.1 2279144 2279887 R catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole; cobalamin synthase complement(2279144..2279887) Escherichia coli 55989 7145737 YP_002403269.1 CDS cobU NC_011748.1 2279884 2280429 R catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP; adenosylcobinamide kinase complement(2279884..2280429) Escherichia coli 55989 7145736 YP_002403270.1 CDS EC55989_2229 NC_011748.1 2280894 2281058 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2280894..2281058) Escherichia coli 55989 7144717 YP_002403271.1 CDS EC55989_2231 NC_011748.1 2282184 2282300 D Evidence 6 : Doubtful CDS; hypothetical protein 2282184..2282300 Escherichia coli 55989 7144718 YP_002403272.1 CDS EC55989_2232 NC_011748.1 2282496 2283710 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; carbohydrate kinase 2282496..2283710 Escherichia coli 55989 7144719 YP_002403273.1 CDS EC55989_2233 NC_011748.1 2283724 2284482 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2283724..2284482 Escherichia coli 55989 7144720 YP_002403274.1 CDS EC55989_2236 NC_011748.1 2285507 2286541 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; phosphotriesterase-related protein 2285507..2286541 Escherichia coli 55989 7144723 YP_002403275.1 CDS EC55989_2238 NC_011748.1 2286685 2286909 R hypothetical protein complement(2286685..2286909) Escherichia coli 55989 7146281 YP_002403276.1 CDS EC55989_2240 NC_011748.1 2287193 2288572 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase, ISL3 family complement(2287193..2288572) Escherichia coli 55989 7144726 YP_002403277.1 CDS EC55989_2241 NC_011748.1 2288856 2289353 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2288856..2289353) Escherichia coli 55989 7144727 YP_002403278.1 CDS EC55989_2242 NC_011748.1 2289254 2289661 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2289254..2289661) Escherichia coli 55989 7144728 YP_002403279.1 CDS EC55989_2243 NC_011748.1 2289915 2290520 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2289915..2290520) Escherichia coli 55989 7144729 YP_002403280.1 CDS EC55989_2244 NC_011748.1 2291810 2292217 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; InterPro motifs Prophage CP4-57 regulatory protein (AlpA) 2291810..2292217 Escherichia coli 55989 7144730 YP_002403281.1 CDS EC55989_2245 NC_011748.1 2292296 2292913 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2292296..2292913 Escherichia coli 55989 7144731 YP_002403282.1 CDS EC55989_2246 NC_011748.1 2293341 2293601 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2293341..2293601 Escherichia coli 55989 7144732 YP_002403284.1 CDS EC55989_2248 NC_011748.1 2293872 2295407 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase ORF 1, IS66 family complement(2293872..2295407) Escherichia coli 55989 7144734 YP_002403285.1 CDS EC55989_2249 NC_011748.1 2295457 2295804 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase ORF 2, IS66 family complement(2295457..2295804) Escherichia coli 55989 7144735 YP_002403286.1 CDS EC55989_2250 NC_011748.1 2297740 2298903 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2297740..2298903 Escherichia coli 55989 7144736 YP_002403287.1 CDS EC55989_2253 NC_011748.1 2300076 2302472 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2300076..2302472 Escherichia coli 55989 7144739 YP_002403288.1 CDS EC55989_2254 NC_011748.1 2302469 2303374 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2302469..2303374 Escherichia coli 55989 7144740 YP_002403289.1 CDS EC55989_2255 NC_011748.1 2303371 2304441 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2303371..2304441 Escherichia coli 55989 7144741 YP_002403290.1 CDS EC55989_2256 NC_011748.1 2304469 2305260 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2304469..2305260 Escherichia coli 55989 7144742 YP_002403291.1 CDS EC55989_2257 NC_011748.1 2305276 2305686 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2305276..2305686 Escherichia coli 55989 7144743 YP_002403292.1 CDS EC55989_2258 NC_011748.1 2305907 2306728 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2305907..2306728 Escherichia coli 55989 7144744 YP_002403293.1 CDS EC55989_2259 NC_011748.1 2306810 2307289 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7519596; Product type h : extrachromosomal origin; antirestriction protein of plasmid origin 2306810..2307289 Escherichia coli 55989 7144745 YP_002403294.1 CDS yeeS NC_011748.1 2307335 2307781 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : factor; DNA repair protein; CP4-44 prophage 2307335..2307781 Escherichia coli 55989 7144746 YP_002403295.1 CDS yeeT NC_011748.1 2307844 2308065 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; CP4-44 prophage 2307844..2308065 Escherichia coli 55989 7148604 YP_002403296.1 CDS yeeU NC_011748.1 2308139 2308507 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; antitoxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 2308139..2308507 Escherichia coli 55989 7148608 YP_002403297.1 CDS yeeW NC_011748.1 2308966 2309160 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; CP4-44 prophage 2308966..2309160 Escherichia coli 55989 7148616 YP_002403298.1 CDS yoeF NC_011748.1 2309601 2309957 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2309601..2309957 Escherichia coli 55989 7148619 YP_002403299.1 CDS yeeX NC_011748.1 2310058 2310453 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2310058..2310453) Escherichia coli 55989 7149350 YP_002403300.1 CDS yeeA NC_011748.1 2310559 2311617 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(2310559..2311617) Escherichia coli 55989 7148623 YP_002403301.1 CDS sbmC NC_011748.1 2311815 2312288 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11850398, 9442027, 8709849; Product type r : regulator; DNA gyrase inhibitor complement(2311815..2312288) Escherichia coli 55989 7148593 YP_002403302.1 CDS dacD NC_011748.1 2312407 2313573 R removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase complement(2312407..2313573) Escherichia coli 55989 7147610 YP_002403303.1 CDS sbcB NC_011748.1 2313782 2315209 D Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates; exonuclease I 2313782..2315209 Escherichia coli 55989 7145844 YP_002403304.1 CDS yeeD NC_011748.1 2315252 2315479 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2315252..2315479) Escherichia coli 55989 7147606 YP_002403305.1 CDS yeeE NC_011748.1 2315493 2316551 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(2315493..2316551) Escherichia coli 55989 7148594 YP_002403306.1 CDS yeeF NC_011748.1 2316730 2318088 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; amino-acid/amine transporter complement(2316730..2318088) Escherichia coli 55989 7148595 YP_002403307.1 CDS yeeY NC_011748.1 2318355 2319284 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(2318355..2319284) Escherichia coli 55989 7148596 YP_002403308.1 CDS yeeZ NC_011748.1 2319330 2320154 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; epimerase, with NAD(P)-binding Rossmann-fold domain complement(2319330..2320154) Escherichia coli 55989 7148624 YP_002403309.1 CDS yoeB NC_011748.1 2320237 2320491 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type f : factor; toxin of the YoeB-YefM toxin-antitoxin system complement(2320237..2320491) Escherichia coli 55989 7148625 YP_002403310.1 CDS yefM NC_011748.1 2320488 2320739 R Antitoxin that counteracts the effect of the YoeB toxin; antitoxin YefM complement(2320488..2320739) Escherichia coli 55989 7149349 YP_002403312.1 CDS hisG NC_011748.1 2321219 2322118 D long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors; ATP phosphoribosyltransferase 2321219..2322118 Escherichia coli 55989 7145305 YP_002403313.1 CDS hisD NC_011748.1 2322124 2323428 D catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer; histidinol dehydrogenase 2322124..2323428 Escherichia coli 55989 7146435 YP_002403314.1 CDS hisC NC_011748.1 2323425 2324495 D catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis; histidinol-phosphate aminotransferase 2323425..2324495 Escherichia coli 55989 7146433 YP_002403315.1 CDS hisB NC_011748.1 2324495 2325562 D catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate; imidazole glycerol-phosphate dehydratase/histidinol phosphatase 2324495..2325562 Escherichia coli 55989 7146432 YP_002403316.1 CDS hisH NC_011748.1 2325562 2326152 D with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide; imidazole glycerol phosphate synthase subunit HisH 2325562..2326152 Escherichia coli 55989 7146431 YP_002403317.1 CDS hisA NC_011748.1 2326152 2326889 D catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide; 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase 2326152..2326889 Escherichia coli 55989 7146436 YP_002403318.1 CDS hisF NC_011748.1 2326871 2327647 D catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase; imidazole glycerol phosphate synthase subunit HisF 2326871..2327647 Escherichia coli 55989 7146430 YP_002403319.1 CDS hisI NC_011748.1 2327641 2328252 D catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis; bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase 2327641..2328252 Escherichia coli 55989 7146434 YP_002403320.1 CDS cld NC_011748.1 2328350 2329330 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98241528; Product type r : regulator; regulator of length of O-antigen component of lipopolysaccharide chains complement(2328350..2329330) Escherichia coli 55989 7146437 YP_002403321.1 CDS ugd NC_011748.1 2329474 2330640 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150218, 96326333; Product type e : enzyme; UDP-glucose 6-dehydrogenase complement(2329474..2330640) Escherichia coli 55989 7145720 YP_002403322.1 CDS gnd NC_011748.1 2330888 2332294 R catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate; 6-phosphogluconate dehydrogenase complement(2330888..2332294) Escherichia coli 55989 7147899 YP_002403323.1 CDS EC55989_2289 NC_011748.1 2332415 2333233 R Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; glycosyl transferase family protein complement(2332415..2333233) Escherichia coli 55989 7146346 YP_002403324.1 CDS EC55989_2290 NC_011748.1 2333246 2334541 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11404020; Product type pe : enzyme; Wzx complement(2333246..2334541) Escherichia coli 55989 7144747 YP_002403325.1 CDS EC55989_2291 NC_011748.1 2334523 2335746 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11404020; Product type pe : enzyme; WbwB complement(2334523..2335746) Escherichia coli 55989 7144748 YP_002403326.1 CDS EC55989_2292 NC_011748.1 2336861 2337811 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11404020; hypothetical protein complement(2336861..2337811) Escherichia coli 55989 7144749 YP_002403327.1 CDS EC55989_2293 NC_011748.1 2337896 2339059 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11404020; Product type pe : enzyme; NnaA complement(2337896..2339059) Escherichia coli 55989 7144750 YP_002403328.1 CDS EC55989_2294 NC_011748.1 2339056 2340321 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11404020; Product type pe : enzyme; NnaC complement(2339056..2340321) Escherichia coli 55989 7144751 YP_002403329.1 CDS EC55989_2295 NC_011748.1 2340327 2341367 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11404020; Product type pe : enzyme; NnaB complement(2340327..2341367) Escherichia coli 55989 7144752 YP_002403330.1 CDS EC55989_2296 NC_011748.1 2341372 2341992 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11404020; Product type pe : enzyme; WckD complement(2341372..2341992) Escherichia coli 55989 7144753 YP_002403331.1 CDS galF NC_011748.1 2342353 2343246 R together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose; UTP-glucose-1-phosphate uridylyltransferase complement(2342353..2343246) Escherichia coli 55989 7144754 YP_002403332.1 CDS gne NC_011748.1 2343489 2344484 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976290; Product type e : enzyme; UDP-N-acetylglucosamine 4-epimerase (UDP-GlcNAc 4-epimerase) complement(2343489..2344484) Escherichia coli 55989 7146248 YP_002403333.1 CDS wcaM NC_011748.1 2344642 2346036 R WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid; colanic acid biosynthesis protein complement(2344642..2346036) Escherichia coli 55989 7146347 YP_002403334.1 CDS wcaL NC_011748.1 2346047 2347267 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : enzyme; glycosyl transferase family protein complement(2346047..2347267) Escherichia coli 55989 7147972 YP_002403335.1 CDS wcaK NC_011748.1 2347264 2348544 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333, 8759852, 11004393; Product type pe : enzyme; pyruvyl transferase complement(2347264..2348544) Escherichia coli 55989 7147971 YP_002403336.1 CDS wzxC NC_011748.1 2348829 2350307 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 8759852; Product type pt : transporter; colanic acid exporter complement(2348829..2350307) Escherichia coli 55989 7147970 YP_002403337.1 CDS wcaJ NC_011748.1 2350309 2351703 R WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid; UDP-glucose lipid carrier transferase complement(2350309..2351703) Escherichia coli 55989 7147977 YP_002403338.1 CDS cpsG NC_011748.1 2351758 2353128 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93106949, 96326333, 7815923, 8759852; Product type e : enzyme; phosphomannomutase complement(2351758..2353128) Escherichia coli 55989 7147969 YP_002403339.1 CDS cpsB NC_011748.1 2353497 2354933 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82100097, 85006781, 92048476, 93122523, 96326333, 7815923, 8759852; Product type e : enzyme; mannose-1-phosphate guanylyltransferase complement(2353497..2354933) Escherichia coli 55989 7145747 YP_002403340.1 CDS wcaI NC_011748.1 2354936 2356159 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15670885, 96326333; Product type pe : enzyme; glycosyl transferase family protein complement(2354936..2356159) Escherichia coli 55989 7145746 YP_002403341.1 CDS nudD NC_011748.1 2356156 2356635 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 10913267, 7592609, 7815923, 8759852; Product type e : enzyme; GDP-mannose mannosyl hydrolase complement(2356156..2356635) Escherichia coli 55989 7147968 YP_002403342.1 CDS fcl NC_011748.1 2356638 2357603 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96326333, 98132401, 9862812, 7815923, 8759852, 9473059; Product type e : enzyme; bifunctional GDP-fucose synthetase: GDP-4-dehydro-6-deoxy-D-mannose epimerase and GDP-4-dehydro-6-L-deoxygalactose reductase complement(2356638..2357603) Escherichia coli 55989 7147038 YP_002403343.1 CDS gmd NC_011748.1 2357606 2358727 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20139699, 97400210, 10673432, 7815923, 8759852, 9257704, 14299611; Product type e : enzyme; GDP-D-mannose dehydratase complement(2357606..2358727) Escherichia coli 55989 7146065 YP_002403344.1 CDS wcaF NC_011748.1 2358754 2359302 R acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); colanic acid biosynthesis acetyltransferase WcaF complement(2358754..2359302) Escherichia coli 55989 7146342 YP_002403345.1 CDS wcaE NC_011748.1 2359318 2360064 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11371548, 96326333, 8759852; Product type pe : enzyme; glycosyl transferase family protein complement(2359318..2360064) Escherichia coli 55989 7147967 YP_002403346.1 CDS wcaD NC_011748.1 2360075 2361292 R essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance; colanic acid biosynthesis protein complement(2360075..2361292) Escherichia coli 55989 7147966 YP_002403347.1 CDS wcaC NC_011748.1 2361267 2362484 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : enzyme; glycosyl transferase family protein complement(2361267..2362484) Escherichia coli 55989 7147965 YP_002403348.1 CDS wcaB NC_011748.1 2362481 2362969 R acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium; colanic acid biosynthesis acetyltransferase WcaB complement(2362481..2362969) Escherichia coli 55989 7147964 YP_002403349.1 CDS wcaA NC_011748.1 2362972 2363811 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96326333; Product type pe : enzyme; glycosyl transferase family protein complement(2362972..2363811) Escherichia coli 55989 7147963 YP_002403350.1 CDS wzc NC_011748.1 2363989 2366151 R Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide); tyrosine kinase complement(2363989..2366151) Escherichia coli 55989 7147962 YP_002403351.1 CDS wzb NC_011748.1 2366154 2366597 R Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis; tyrosine phosphatase complement(2366154..2366597) Escherichia coli 55989 7147976 YP_002403352.1 CDS wza NC_011748.1 2366603 2367742 R Evidence 2b : Function of strongly homologous gene; PubMedId : 15090537, 96326333, 8759852, 8763957; Product type lp : lipoprotein; lipoprotein required for capsular polysaccharide translocation through the outer membrane complement(2366603..2367742) Escherichia coli 55989 7147975 YP_002403353.1 CDS yegH NC_011748.1 2368401 2369984 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; fused membrane protein ; membrane protein 2368401..2369984 Escherichia coli 55989 7147974 YP_002403354.1 CDS asmA NC_011748.1 2370258 2372111 R YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs; assembly protein complement(2370258..2372111) Escherichia coli 55989 7148629 YP_002403355.1 CDS dcd NC_011748.1 2372133 2372714 R Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis; deoxycytidine triphosphate deaminase complement(2372133..2372714) Escherichia coli 55989 7145566 YP_002403356.1 CDS udk NC_011748.1 2372806 2373447 R functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor; uridine kinase complement(2372806..2373447) Escherichia coli 55989 7145855 YP_002403357.1 CDS yegE NC_011748.1 2373765 2377082 D contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction; sensor protein 2373765..2377082 Escherichia coli 55989 7147897 YP_002403358.1 CDS alkA NC_011748.1 2377121 2377978 R inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine; 3-methyladenine DNA glycosylase complement(2377121..2377978) Escherichia coli 55989 7148628 YP_002403359.1 CDS yegD NC_011748.1 2378112 2379464 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 6094528, 7940673, 7984428; Product type pf : factor; chaperone 2378112..2379464 Escherichia coli 55989 7145481 YP_002403360.1 CDS yegI NC_011748.1 2379476 2381425 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2379476..2381425) Escherichia coli 55989 7148627 YP_002403361.1 CDS yegK NC_011748.1 2381413 2382174 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2381413..2382174) Escherichia coli 55989 7148630 YP_002403362.1 CDS yegL NC_011748.1 2382171 2382830 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2382171..2382830) Escherichia coli 55989 7148631 YP_002403363.1 CDS mdtA NC_011748.1 2384046 2385293 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtA 2384046..2385293 Escherichia coli 55989 7145307 YP_002403364.1 CDS mdtB NC_011748.1 2385293 2388415 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtB 2385293..2388415 Escherichia coli 55989 7146802 YP_002403365.1 CDS mdtC NC_011748.1 2388416 2391493 D Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate; multidrug efflux system subunit MdtC 2388416..2391493 Escherichia coli 55989 7146803 YP_002403366.1 CDS mdtD NC_011748.1 2391494 2392909 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12107134, 21450803, 8282725; Product type t : transporter; multidrug efflux system protein MdtE 2391494..2392909 Escherichia coli 55989 7146804 YP_002403367.1 CDS baeS NC_011748.1 2392906 2394309 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; signal transduction histidine-protein kinase BaeS 2392906..2394309 Escherichia coli 55989 7146805 YP_002403368.1 CDS baeR NC_011748.1 2394306 2395028 D response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport; DNA-binding transcriptional regulator BaeR 2394306..2395028 Escherichia coli 55989 7145594 YP_002403369.1 CDS yegP NC_011748.1 2395219 2395551 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2395219..2395551 Escherichia coli 55989 7145593 YP_002403370.1 CDS EC55989_2338 NC_011748.1 2395760 2396056 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2395760..2396056 Escherichia coli 55989 7148633 YP_002403371.1 CDS EC55989_2339 NC_011748.1 2396058 2396354 D Evidence 4 : Homologs of previously reported genes of unknown function; plasmid stabilisation system protein 2396058..2396354 Escherichia coli 55989 7144755 YP_002403372.1 CDS yegQ NC_011748.1 2396457 2397818 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; peptidase 2396457..2397818 Escherichia coli 55989 7144756 YP_002403373.1 CDS EC55989_2341 NC_011748.1 2398011 2398160 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2398011..2398160) Escherichia coli 55989 7147580 YP_002403374.1 CDS yegR NC_011748.1 2398148 2398465 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2398148..2398465) Escherichia coli 55989 7144757 YP_002403375.1 CDS yegS NC_011748.1 2398880 2399779 D cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role; lipid kinase 2398880..2399779 Escherichia coli 55989 7148635 YP_002403376.1 CDS gatR NC_011748.1 2399861 2400640 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7772602; Product type r : regulator; Galactitol utilization operon repressor complement(2399861..2400640) Escherichia coli 55989 7148636 YP_002403377.1 CDS gatD NC_011748.1 2400740 2401780 R Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate; galactitol-1-phosphate dehydrogenase complement(2400740..2401780) Escherichia coli 55989 7146267 YP_002403378.1 CDS gatC NC_011748.1 2401828 2403183 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 76024805, 77192083, 97113438, 7772602; Product type t : transporter; PTS system galactitol-specific transporter subunit IIC complement(2401828..2403183) Escherichia coli 55989 7146266 YP_002403379.1 CDS gatB NC_011748.1 2403187 2403471 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIB complement(2403187..2403471) Escherichia coli 55989 7146265 YP_002403380.1 CDS gatA NC_011748.1 2403502 2403954 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system galactitol-specific transporter subunit IIA complement(2403502..2403954) Escherichia coli 55989 7146264 YP_002403381.1 CDS gatY NC_011748.1 2405250 2406104 R catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase complement(2405250..2406104) Escherichia coli 55989 7146270 YP_002403382.1 CDS fbaB NC_011748.1 2406414 2407466 R catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate; fructose-bisphosphate aldolase complement(2406414..2407466) Escherichia coli 55989 7146268 YP_002403383.1 CDS yegT NC_011748.1 2407723 2409000 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; hydrophilic substrate transporter; MFS superfamily 2407723..2409000 Escherichia coli 55989 7146063 YP_002403384.1 CDS yegU NC_011748.1 2408997 2410001 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; (phospho)hydrolase 2408997..2410001 Escherichia coli 55989 7148637 YP_002403385.1 CDS yegV NC_011748.1 2409998 2410963 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; kinase 2409998..2410963 Escherichia coli 55989 7148638 YP_002403386.1 CDS yegW NC_011748.1 2410937 2411683 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(2410937..2411683) Escherichia coli 55989 7148639 YP_002403387.1 CDS yegX NC_011748.1 2411735 2412553 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane-bound hydrolase complement(2411735..2412553) Escherichia coli 55989 7148640 YP_002403388.1 CDS thiD NC_011748.1 2412618 2413418 R catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine; phosphomethylpyrimidine kinase complement(2412618..2413418) Escherichia coli 55989 7148641 YP_002403389.1 CDS thiM NC_011748.1 2413415 2414203 R catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP; hydroxyethylthiazole kinase complement(2413415..2414203) Escherichia coli 55989 7147783 YP_002403390.1 CDS yohL NC_011748.1 2414426 2414698 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2414426..2414698) Escherichia coli 55989 7145308 YP_002403391.1 CDS rncA NC_011748.1 2414819 2415643 D membrane protein conferring nickel and cobalt resistance; nickel/cobalt efflux protein RcnA 2414819..2415643 Escherichia coli 55989 7149357 YP_002403392.1 CDS yohN NC_011748.1 2415682 2416200 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2415682..2416200 Escherichia coli 55989 7147446 YP_002403393.1 CDS yehA NC_011748.1 2416282 2417316 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein complement(2416282..2417316) Escherichia coli 55989 7149358 YP_002403394.1 CDS yehB NC_011748.1 2417332 2419812 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; outer membrane protein complement(2417332..2419812) Escherichia coli 55989 7148642 YP_002403395.1 CDS yehC NC_011748.1 2419828 2420502 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; membrane-associated pilin chaperone complement(2419828..2420502) Escherichia coli 55989 7148643 YP_002403396.1 CDS yehD NC_011748.1 2420583 2421125 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein complement(2420583..2421125) Escherichia coli 55989 7148644 YP_002403397.1 CDS yehE NC_011748.1 2421418 2421699 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2421418..2421699) Escherichia coli 55989 7148645 YP_002403398.1 CDS mrp NC_011748.1 2421962 2423071 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91080852, 15601724, 2259334; Product type t : transporter; ATPase complement(2421962..2423071) Escherichia coli 55989 7148646 YP_002403399.1 CDS metG NC_011748.1 2423203 2425236 D methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content; methionyl-tRNA synthetase 2423203..2425236 Escherichia coli 55989 7146905 YP_002403400.1 CDS insA NC_011748.1 2426410 2426685 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA 2426410..2426685 Escherichia coli 55989 7144758 YP_002403401.1 CDS insB NC_011748.1 2426604 2427107 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 transposase InsAB' 2426604..2427107 Escherichia coli 55989 7146577 YP_002403402.1 CDS yehS NC_011748.1 2427226 2427696 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2427226..2427696) Escherichia coli 55989 7146589 YP_002403403.1 CDS yehT NC_011748.1 2427743 2428462 R unknown function; when overproduced it confers drug-resistance; two-component response-regulatory protein YehT complement(2427743..2428462) Escherichia coli 55989 7148647 YP_002403404.1 CDS yehU NC_011748.1 2428459 2430144 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15522865, 15322361; Product type rc : receptor; sensory kinase in two-component system with YehT complement(2428459..2430144) Escherichia coli 55989 7148648 YP_002403405.1 CDS mlrA NC_011748.1 2430366 2431097 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11489123; Product type r : regulator; DNA-binding transcriptional regulator 2430366..2431097 Escherichia coli 55989 7148649 YP_002403406.1 CDS yohO NC_011748.1 2431157 2431264 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2431157..2431264 Escherichia coli 55989 7146862 YP_002403407.1 CDS yehW NC_011748.1 2431245 2431976 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: permease component of ABC superfamily transporter complement(2431245..2431976) Escherichia coli 55989 7149359 YP_002403408.1 CDS yehX NC_011748.1 2431981 2432907 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: ATP-binding component of ABC superfamily transporter complement(2431981..2432907) Escherichia coli 55989 7148650 YP_002403409.1 CDS yehY NC_011748.1 2432900 2434057 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: permease component of ABC superfamily complement(2432900..2434057) Escherichia coli 55989 7148651 YP_002403410.1 CDS yehZ NC_011748.1 2434064 2434981 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15251200; Product type pt : transporter; transporter subunit: periplasmic-binding component of ABC superfamily complement(2434064..2434981) Escherichia coli 55989 7148652 YP_002403411.1 CDS bglX NC_011748.1 2435192 2437489 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96303506; Product type e : enzyme; beta-D-glucoside glucohydrolase, periplasmic complement(2435192..2437489) Escherichia coli 55989 7148653 YP_002403412.1 CDS dld NC_011748.1 2437685 2439400 D component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent; D-lactate dehydrogenase 2437685..2439400 Escherichia coli 55989 7145623 YP_002403413.1 CDS pbpG NC_011748.1 2439438 2440370 R specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7; D-alanyl-D-alanine endopeptidase complement(2439438..2440370) Escherichia coli 55989 7145927 YP_002403414.1 CDS yohC NC_011748.1 2440544 2441131 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(2440544..2441131) Escherichia coli 55989 7147119 YP_002403415.1 CDS yohD NC_011748.1 2441301 2441879 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2441301..2441879 Escherichia coli 55989 7149351 YP_002403416.1 CDS yohF NC_011748.1 2442009 2442770 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acetoin dehydrogenase complement(2442009..2442770) Escherichia coli 55989 7149352 YP_002403417.1 CDS yohG NC_011748.1 2442823 2443911 R may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance outer membrane protein MdtQ complement(2442823..2443911) Escherichia coli 55989 7149353 YP_002403418.1 CDS dusC NC_011748.1 2444939 2445886 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase C complement(2444939..2445886) Escherichia coli 55989 7149354 YP_002403419.1 CDS yohJ NC_011748.1 2446125 2446523 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2446125..2446523 Escherichia coli 55989 7145961 YP_002403420.1 CDS yohK NC_011748.1 2446520 2447215 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2446520..2447215 Escherichia coli 55989 7149355 YP_002403421.1 CDS cdd NC_011748.1 2447345 2448229 D Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis; cytidine deaminase 2447345..2448229 Escherichia coli 55989 7149356 YP_002403422.1 CDS sanA NC_011748.1 2448379 2449098 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 96125233, 1567863, 8550448; hypothetical protein 2448379..2449098 Escherichia coli 55989 7145683 YP_002403423.1 CDS yeiS NC_011748.1 2449101 2449340 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2449101..2449340 Escherichia coli 55989 7147600 YP_002403424.1 CDS yeiT NC_011748.1 2449659 2450897 D function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain; oxidoreductase 2449659..2450897 Escherichia coli 55989 7148666 YP_002403425.1 CDS yeiA NC_011748.1 2450920 2452125 D catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines; dihydropyrimidine dehydrogenase 2450920..2452125 Escherichia coli 55989 7148667 YP_002403426.1 CDS mglC NC_011748.1 2452196 2453206 R ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex; beta-methylgalactoside transporter inner membrane protein complement(2452196..2453206) Escherichia coli 55989 7148654 YP_002403427.1 CDS mglA NC_011748.1 2453222 2454742 R with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains; galactose/methyl galaxtoside transporter ATP-binding protein complement(2453222..2454742) Escherichia coli 55989 7146841 YP_002403428.1 CDS mglB NC_011748.1 2454803 2455801 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87286407, 92049246, 1719366, 3057628, 3302609, 3600760, 6340108, 6885805, 7012152, 9298646; Product type t : transporter; methyl-galactoside transporter subunit ; periplasmic-binding component of ABC superfamily complement(2454803..2455801) Escherichia coli 55989 7146839 YP_002403429.1 CDS galS NC_011748.1 2456081 2457121 R negative regulator of the mglBAC operon for galactose utilization; DNA-binding transcriptional regulator GalS complement(2456081..2457121) Escherichia coli 55989 7146840 YP_002403430.1 CDS EC55989_2402 NC_011748.1 2457111 2457314 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2457111..2457314 Escherichia coli 55989 7146253 YP_002403431.1 CDS yeiB NC_011748.1 2457263 2458420 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(2457263..2458420) Escherichia coli 55989 7144766 YP_002403432.1 CDS folE NC_011748.1 2458437 2459105 R involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer; GTP cyclohydrolase I complement(2458437..2459105) Escherichia coli 55989 7148655 YP_002403433.1 CDS EC55989_2405 NC_011748.1 2459259 2459435 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2459259..2459435 Escherichia coli 55989 7146172 YP_002403434.1 CDS frmC NC_011748.1 2459363 2460199 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 16567800; Product type e : enzyme; S-formylglutathione hydrolase 2459363..2460199 Escherichia coli 55989 7144767 YP_002403435.1 CDS cirA NC_011748.1 2460231 2462222 R Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein; colicin I receptor complement(2460231..2462222) Escherichia coli 55989 7146191 YP_002403436.1 CDS EC55989_2408 NC_011748.1 2462215 2462418 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2462215..2462418) Escherichia coli 55989 7145708 YP_002403437.1 CDS lysP NC_011748.1 2462515 2463984 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92250419, 94252996, 1315732, 7551055; Product type t : transporter; lysine transporter complement(2462515..2463984) Escherichia coli 55989 7144768 YP_002403438.1 CDS yeiE NC_011748.1 2464189 2465070 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12400704, 1315732; Product type pr : regulator; DNA-binding transcriptional regulator complement(2464189..2465070) Escherichia coli 55989 7146757 YP_002403439.1 CDS yeiH NC_011748.1 2465169 2466218 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2465169..2466218 Escherichia coli 55989 7148657 YP_002403440.1 CDS nfo NC_011748.1 2466292 2467149 D Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues; endonuclease IV 2466292..2467149 Escherichia coli 55989 7148658 YP_002403441.1 CDS yeiI NC_011748.1 2467153 2468241 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 2467153..2468241 Escherichia coli 55989 7146987 YP_002403442.1 CDS yeiJ NC_011748.1 2468297 2469547 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sodium/proton nucleoside transporter complement(2468297..2469547) Escherichia coli 55989 7148659 YP_002403443.1 CDS rihB NC_011748.1 2469647 2470588 R Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively; ribonucleoside hydrolase 2 complement(2469647..2470588) Escherichia coli 55989 7148660 YP_002403444.1 CDS yeiL NC_011748.1 2470757 2471416 D activator of nucleoside metabolism; DNA-binding transcriptional activator YeiL 2470757..2471416 Escherichia coli 55989 7147416 YP_002403445.1 CDS yeiM NC_011748.1 2471484 2472734 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sodium/proton nucleoside transporter complement(2471484..2472734) Escherichia coli 55989 7148661 YP_002403446.1 CDS yeiN NC_011748.1 2472828 2473766 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2472828..2473766) Escherichia coli 55989 7148662 YP_002403447.1 CDS yeiC NC_011748.1 2473754 2474695 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein complement(2473754..2474695) Escherichia coli 55989 7148663 YP_002403448.1 CDS fruA NC_011748.1 2475119 2476810 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system fructose-specific transporter subunit IIBC complement(2475119..2476810) Escherichia coli 55989 7148656 YP_002403449.1 CDS fruK NC_011748.1 2476827 2477765 R converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers; 1-phosphofructokinase complement(2476827..2477765) Escherichia coli 55989 7146195 YP_002403450.1 CDS fruB NC_011748.1 2477765 2478895 R phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr; bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein complement(2477765..2478895) Escherichia coli 55989 7146197 YP_002403451.1 CDS setB NC_011748.1 2479263 2480444 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10438463, 10209755; Product type t : transporter; lactose/glucose efflux system 2479263..2480444 Escherichia coli 55989 7146196 YP_002403452.1 CDS EC55989_2424 NC_011748.1 2480441 2480827 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2480441..2480827) Escherichia coli 55989 7147637 YP_002403453.1 CDS EC55989_2425 NC_011748.1 2480595 2481422 D Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein; elongation factor P 2480595..2481422 Escherichia coli 55989 7144769 YP_002403454.1 CDS yeiQ NC_011748.1 2481645 2483111 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; sugar dehydrogenase, NAD-dependent 2481645..2483111 Escherichia coli 55989 7144770 YP_002403455.1 CDS yeiR NC_011748.1 2483229 2484215 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 2483229..2484215 Escherichia coli 55989 7148664 YP_002403456.1 CDS yeiU NC_011748.1 2484254 2484967 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15778224; Product type e : enzyme; undecaprenyl pyrophosphate phosphatase 2484254..2484967 Escherichia coli 55989 7148665 YP_002403457.1 CDS spr NC_011748.1 2485379 2485945 D by similarity, Spr seems to have peptidase activity; involved in thermoresistance; outer membrane lipoprotein 2485379..2485945 Escherichia coli 55989 7148668 YP_002403458.1 CDS rtn NC_011748.1 2486126 2487682 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2486126..2487682 Escherichia coli 55989 7147695 YP_002403459.1 CDS yejA NC_011748.1 2487764 2489578 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; oligopeptide transporter subunit ; periplasmic-binding component of ABC superfamily transporter 2487764..2489578 Escherichia coli 55989 7147555 YP_002403460.1 CDS yejB NC_011748.1 2489579 2490673 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; oligopeptide transporter subunit; permease component of ABC superfamily 2489579..2490673 Escherichia coli 55989 7148669 YP_002403461.1 CDS yejE NC_011748.1 2490673 2491698 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; oligopeptide transporter subunit ; permease component of ABC superfamily transporter 2490673..2491698 Escherichia coli 55989 7148670 YP_002403462.1 CDS yejF NC_011748.1 2491700 2493289 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; fused oligopeptide transporter subunits of ABC superfamily: ATP-binding components 2491700..2493289 Escherichia coli 55989 7148671 YP_002403463.1 CDS yejG NC_011748.1 2493293 2493637 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2493293..2493637) Escherichia coli 55989 7148672 YP_002403464.1 CDS bcr NC_011748.1 2493970 2495160 R Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance; bicyclomycin/multidrug efflux system protein complement(2493970..2495160) Escherichia coli 55989 7148673 YP_002403465.1 CDS rsuA NC_011748.1 2495188 2495883 R catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA; 16S rRNA pseudouridylate synthase A complement(2495188..2495883) Escherichia coli 55989 7145601 YP_002403466.1 CDS yejH NC_011748.1 2496032 2497792 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; nucleic acid ATP-dependent helicase 2496032..2497792 Escherichia coli 55989 7147545 YP_002403467.1 CDS rplY NC_011748.1 2497917 2498201 D the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response; 50S ribosomal protein L25 2497917..2498201 Escherichia coli 55989 7148674 YP_002403468.1 CDS yejK NC_011748.1 2498340 2499347 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99296598, 10368163; Product type f : factor; nucleoid-associated protein NdpA complement(2498340..2499347) Escherichia coli 55989 7147485 YP_002403469.1 CDS yejL NC_011748.1 2499529 2499756 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2499529..2499756 Escherichia coli 55989 7148675 YP_002403470.1 CDS yejM NC_011748.1 2499776 2501536 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase, inner membrane-associated 2499776..2501536 Escherichia coli 55989 7148676 YP_002403471.1 CDS EC55989_2443 NC_011748.1 2501666 2501827 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2501666..2501827) Escherichia coli 55989 7145334 YP_002403472.1 CDS narP NC_011748.1 2504702 2505349 D nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes; transcriptional regulator NarP 2504702..2505349 Escherichia coli 55989 7148679 YP_002403473.1 CDS ccmH NC_011748.1 2505384 2506436 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 91194558, 95362656, 9914305, 7635817; Product type pe : enzyme; heme lyase, CcmH subunit complement(2505384..2506436) Escherichia coli 55989 7146973 YP_002403474.1 CDS ccmG NC_011748.1 2506433 2506990 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 9716493, 9770295, 11256948, 11350062, 11843181, 7635817, 9537397; Product type e : enzyme; periplasmic thioredoxin of cytochrome c-type biogenesis complement(2506433..2506990) Escherichia coli 55989 7145681 YP_002403475.1 CDS ccmF NC_011748.1 2506987 2508930 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 11756453, 12196152, 87260957, 8842153, 91194558, 95362656, 9716493, 7635817; Product type e : enzyme; heme lyase, CcmF subunit complement(2506987..2508930) Escherichia coli 55989 7145680 YP_002403476.1 CDS ccmE NC_011748.1 2508927 2509406 R CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane; cytochrome c-type biogenesis protein CcmE complement(2508927..2509406) Escherichia coli 55989 7145679 YP_002403477.1 CDS ccmD NC_011748.1 2509403 2509612 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type f : factor; cytochrome c biogenesis protein complement(2509403..2509612) Escherichia coli 55989 7145678 YP_002403478.1 CDS ccmC NC_011748.1 2509609 2510346 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 14532274, 21413853, 95362656, 7635817; Product type t : transporter; heme exporter subunit ; membrane component of ABC superfamily complement(2509609..2510346) Escherichia coli 55989 7145677 YP_002403479.1 CDS ccmB NC_011748.1 2510388 2511050 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10339610, 12196152, 95362656, 9716493, 7635817; Product type t : transporter; heme exporter subunit ; membrane component of ABC superfamily complement(2510388..2511050) Escherichia coli 55989 7145676 YP_002403480.1 CDS ccmA NC_011748.1 2511047 2511670 R ATP-binding protein; required for proper cytochrome c maturation; cytochrome c biogenesis protein CcmA complement(2511047..2511670) Escherichia coli 55989 7145675 YP_002403481.1 CDS napC NC_011748.1 2511683 2512285 R with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone; cytochrome c-type protein NapC complement(2511683..2512285) Escherichia coli 55989 7145674 YP_002403482.1 CDS napB NC_011748.1 2512295 2512744 R small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA; citrate reductase cytochrome c-type subunit complement(2512295..2512744) Escherichia coli 55989 7146962 YP_002403483.1 CDS napH NC_011748.1 2512741 2513604 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; quinol dehydrogenase membrane component complement(2512741..2513604) Escherichia coli 55989 7146961 YP_002403484.1 CDS napG NC_011748.1 2513591 2514286 R part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway; quinol dehydrogenase periplasmic component complement(2513591..2514286) Escherichia coli 55989 7146966 YP_002403485.1 CDS napA NC_011748.1 2514293 2516779 R periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC; nitrate reductase catalytic subunit complement(2514293..2516779) Escherichia coli 55989 7146965 YP_002403486.1 CDS napD NC_011748.1 2516776 2517039 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96228696, 99395037; Product type f : factor; assembly protein for periplasmic nitrate reductase complement(2516776..2517039) Escherichia coli 55989 7146960 YP_002403487.1 CDS napF NC_011748.1 2517029 2517523 R Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA.; ferredoxin-type protein complement(2517029..2517523) Escherichia coli 55989 7146963 YP_002403488.1 CDS EC55989_2463 NC_011748.1 2517623 2517796 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2517623..2517796 Escherichia coli 55989 7146964 YP_002403489.1 CDS eco NC_011748.1 2517931 2518419 D serine protease inhibitor, inhibits trypsin and other proteases; ecotin 2517931..2518419 Escherichia coli 55989 7144772 YP_002403490.1 CDS mqo NC_011748.1 2518568 2520214 R malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate; malate:quinone oxidoreductase complement(2518568..2520214) Escherichia coli 55989 7145973 YP_002403491.1 CDS yojI NC_011748.1 2520432 2522075 R efflux pump for the antibacterial peptide microcin J25; multidrug transporter membrane protein/ATP-binding component complement(2520432..2522075) Escherichia coli 55989 7146894 YP_002403492.1 CDS alkB NC_011748.1 2522151 2522801 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12226668, 12517444, 12862460, 14527653, 87057220, 88151899, 92017669, 3536913, 3887409, 7928996; Product type e : enzyme; oxidative demethylase of N1-methyladenine or N3-methylcytosine DNA lesions complement(2522151..2522801) Escherichia coli 55989 7149360 YP_002403493.1 CDS ada NC_011748.1 2522801 2523865 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91073391, 93272965, 94252990; Product type r : regulator; fused DNA-binding transcriptional dual regulator ; O6-methylguanine-DNA methyltransferase complement(2522801..2523865) Escherichia coli 55989 7145482 YP_002403494.1 CDS yojL NC_011748.1 2523939 2524994 R catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway; thiamine biosynthesis lipoprotein ApbE complement(2523939..2524994) Escherichia coli 55989 7145452 YP_002403495.1 CDS ompC NC_011748.1 2525106 2526209 R allows for ions and hydrophilic solutes to cross the outer membrane; outer membrane porin protein C complement(2525106..2526209) Escherichia coli 55989 7149361 YP_002403496.1 CDS rcsD NC_011748.1 2526948 2529620 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 21206231, 2404948, 7984428; Product type r : regulator; phosphotransfer intermediate protein in two-component regulatory system with RcsBC 2526948..2529620 Escherichia coli 55989 7146856 YP_002403497.1 CDS rcsB NC_011748.1 2529637 2530287 D two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF; transcriptional regulator RcsB 2529637..2530287 Escherichia coli 55989 7147350 YP_002403498.1 CDS rcsC NC_011748.1 2530487 2533288 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11758943, 12864862, 14651646, 20032358, 21450811, 88227838, 90130299, 92048476, 9209051, 2404948, 8366025; Product type r : regulator; hybrid sensory kinase in two-component regulatory system with RcsB and YojN complement(2530487..2533288) Escherichia coli 55989 7147348 YP_002403499.1 CDS yfaP NC_011748.1 2533611 2534387 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2533611..2534387) Escherichia coli 55989 7147349 YP_002403500.1 CDS yfaQ NC_011748.1 2534392 2536041 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2534392..2536041) Escherichia coli 55989 7148686 YP_002403501.1 CDS EC55989_2476 NC_011748.1 2536042 2540661 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; large extracellular alpha-helical protein complement(2536042..2540661) Escherichia coli 55989 7148687 YP_002403502.1 CDS yfaT NC_011748.1 2540580 2541203 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2540580..2541203) Escherichia coli 55989 7144773 YP_002403503.1 CDS yfaA NC_011748.1 2541200 2542888 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2541200..2542888) Escherichia coli 55989 7148688 YP_002403504.1 CDS gyrA NC_011748.1 2543037 2545664 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit A complement(2543037..2545664) Escherichia coli 55989 7148680 YP_002403505.1 CDS ubiG NC_011748.1 2545811 2546533 D Involved in ubiquinone biosynthesis; 3-demethylubiquinone-9 3-methyltransferase 2545811..2546533 Escherichia coli 55989 7146388 YP_002403506.1 CDS yfaL NC_011748.1 2546661 2550395 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15659678; Product type f : factor; adhesin complement(2546661..2550395) Escherichia coli 55989 7147893 YP_002403507.1 CDS nrdA NC_011748.1 2551091 2553376 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 2551091..2553376 Escherichia coli 55989 7148684 YP_002403508.1 CDS nrdB NC_011748.1 2553465 2554595 D B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA; ribonucleotide-diphosphate reductase subunit beta 2553465..2554595 Escherichia coli 55989 7147018 YP_002403509.1 CDS yfaE NC_011748.1 2554595 2554849 D plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases; 2Fe-2S ferredoxin 2554595..2554849 Escherichia coli 55989 7147019 YP_002403510.1 CDS inaA NC_011748.1 2554903 2555553 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 92165728, 1537798, 6087316; hypothetical protein complement(2554903..2555553) Escherichia coli 55989 7148682 YP_002403511.1 CDS yfaH NC_011748.1 2555768 2555974 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2555768..2555974 Escherichia coli 55989 7144774 YP_002403512.1 CDS glpQ NC_011748.1 2556016 2557092 R hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic; glycerophosphodiester phosphodiesterase complement(2556016..2557092) Escherichia coli 55989 7148683 YP_002403513.1 CDS glpT NC_011748.1 2557097 2558455 R catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell; sn-glycerol-3-phosphate transporter complement(2557097..2558455) Escherichia coli 55989 7146323 YP_002403514.1 CDS glpA NC_011748.1 2558728 2560356 D anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor; sn-glycerol-3-phosphate dehydrogenase subunit A 2558728..2560356 Escherichia coli 55989 7146325 YP_002403515.1 CDS glpB NC_011748.1 2560346 2561605 D sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters; anaerobic glycerol-3-phosphate dehydrogenase subunit B 2560346..2561605 Escherichia coli 55989 7146315 YP_002403516.1 CDS glpC NC_011748.1 2561602 2562792 D anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate; sn-glycerol-3-phosphate dehydrogenase subunit C 2561602..2562792 Escherichia coli 55989 7146316 YP_002403517.1 CDS yfaD NC_011748.1 2562986 2563888 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2562986..2563888 Escherichia coli 55989 7146317 YP_002403518.1 CDS yfaY NC_011748.1 2564454 2565656 R Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A complement(2564454..2565656) Escherichia coli 55989 7148689 YP_002403519.1 CDS yfaZ NC_011748.1 2565756 2566298 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; outer membrane porin protein complement(2565756..2566298) Escherichia coli 55989 7148690 YP_002403520.1 CDS yfaO NC_011748.1 2566577 2567002 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : enzyme; NUDIX hydrolase 2566577..2567002 Escherichia coli 55989 7148691 YP_002403521.1 CDS ais NC_011748.1 2567041 2567643 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2567041..2567643) Escherichia coli 55989 7148685 YP_002403522.1 CDS yfbE NC_011748.1 2567933 2569090 D catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose; UDP-4-amino-4-deoxy-L-arabinose--oxoglutarate aminotransferase 2567933..2569090 Escherichia coli 55989 7145477 YP_002403523.1 CDS yfbF NC_011748.1 2569094 2570062 D catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate; undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase 2569094..2570062 Escherichia coli 55989 7148693 YP_002403524.1 CDS yfbG NC_011748.1 2570062 2572044 D Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains; bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase 2570062..2572044 Escherichia coli 55989 7148694 YP_002403525.1 CDS yfbH NC_011748.1 2572041 2572931 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2572041..2572931 Escherichia coli 55989 7148695 YP_002403526.1 CDS arnT NC_011748.1 2572931 2574583 D catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A; 4-amino-4-deoxy-L-arabinose transferase 2572931..2574583 Escherichia coli 55989 7148696 YP_002403527.1 CDS yfbW NC_011748.1 2574580 2574915 D Evidence 4 : Homologs of previously reported genes of unknown function; inner membrane protein 2574580..2574915 Escherichia coli 55989 7145538 YP_002403528.1 CDS yfbJ NC_011748.1 2574915 2575301 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2574915..2575301 Escherichia coli 55989 7148705 YP_002403529.1 CDS pmrD NC_011748.1 2575295 2575561 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96015440, 15569938; Product type pt : transporter; polymyxin resistance protein B complement(2575295..2575561) Escherichia coli 55989 7148697 YP_002403530.1 CDS menE NC_011748.1 2575671 2577026 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96186953, 8626063; Product type e : enzyme; O-succinylbenzoic acid--CoA ligase complement(2575671..2577026) Escherichia coli 55989 7147200 YP_002403531.1 CDS menC NC_011748.1 2577023 2577985 R catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate; O-succinylbenzoate synthase complement(2577023..2577985) Escherichia coli 55989 7146821 YP_002403532.1 CDS menB NC_011748.1 2577985 2578842 R catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA; naphthoate synthase complement(2577985..2578842) Escherichia coli 55989 7146819 YP_002403533.1 CDS yfbB NC_011748.1 2578857 2579615 R catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; acyl-CoA thioester hydrolase complement(2578857..2579615) Escherichia coli 55989 7146818 YP_002403534.1 CDS menD NC_011748.1 2579612 2581282 R SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis; 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylate synthase complement(2579612..2581282) Escherichia coli 55989 7148692 YP_002403535.1 CDS menF NC_011748.1 2581371 2582666 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9150206, 96140724, 2666397, 7984428, 8549818, 8764478; Product type e : enzyme; isochorismate synthase 2 complement(2581371..2582666) Escherichia coli 55989 7146820 YP_002403536.1 CDS elaB NC_011748.1 2582745 2583050 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2582745..2583050) Escherichia coli 55989 7146822 YP_002403537.1 CDS elaA NC_011748.1 2583105 2583566 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein complement(2583105..2583566) Escherichia coli 55989 7145984 YP_002403538.1 CDS elaC NC_011748.1 2583631 2584548 D member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions; ribonuclease Z 2583631..2584548 Escherichia coli 55989 7145983 YP_002403539.1 CDS elaD NC_011748.1 2584736 2585956 D ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system; deubiquitinase 2584736..2585956 Escherichia coli 55989 7145985 YP_002403540.1 CDS EC55989_2518 NC_011748.1 2586601 2586951 D Evidence 4 : Homologs of previously reported genes of unknown function; Zn-dependent exopeptidases 2586601..2586951 Escherichia coli 55989 7145986 YP_002403541.1 CDS yfbM NC_011748.1 2587077 2587580 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2587077..2587580 Escherichia coli 55989 7144775 YP_002403542.1 CDS nuoN NC_011748.1 2587647 2589104 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit N complement(2587647..2589104) Escherichia coli 55989 7148698 YP_002403543.1 CDS nuoM NC_011748.1 2589111 2590640 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit M complement(2589111..2590640) Escherichia coli 55989 7147055 YP_002403544.1 CDS nuoL NC_011748.1 2590804 2592645 R Catalyzes the transfer of electrons from NADH to ubiquinone; NADH dehydrogenase subunit L complement(2590804..2592645) Escherichia coli 55989 7147054 YP_002403545.1 CDS nuoK NC_011748.1 2592642 2592944 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit K complement(2592642..2592944) Escherichia coli 55989 7147053 YP_002403546.1 CDS nuoJ NC_011748.1 2592941 2593495 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit J complement(2592941..2593495) Escherichia coli 55989 7147052 YP_002403547.1 CDS nuoI NC_011748.1 2593507 2594049 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit I complement(2593507..2594049) Escherichia coli 55989 7147051 YP_002403548.1 CDS nuoH NC_011748.1 2594064 2595041 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit H complement(2594064..2595041) Escherichia coli 55989 7147050 YP_002403549.1 CDS nuoG NC_011748.1 2595038 2597770 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit G complement(2595038..2597770) Escherichia coli 55989 7147049 YP_002403550.1 CDS nuoF NC_011748.1 2597817 2599154 R shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase; NADH dehydrogenase I subunit F complement(2597817..2599154) Escherichia coli 55989 7147048 YP_002403551.1 CDS nuoE NC_011748.1 2599151 2599651 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit E complement(2599151..2599651) Escherichia coli 55989 7147047 YP_002403552.1 CDS nuoC NC_011748.1 2599654 2601456 R NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms; bifunctional NADH:ubiquinone oxidoreductase subunit C/D complement(2599654..2601456) Escherichia coli 55989 7147046 YP_002403553.1 CDS nuoB NC_011748.1 2601550 2602212 R The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen; NADH dehydrogenase subunit B complement(2601550..2602212) Escherichia coli 55989 7147045 YP_002403554.1 CDS nuoA NC_011748.1 2602228 2602671 R Catalyzes the transfer of electrons from NADH to quinone; NADH dehydrogenase subunit A complement(2602228..2602671) Escherichia coli 55989 7147044 YP_002403555.1 CDS lrhA NC_011748.1 2603302 2604240 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123461, 9882671, 7565112; Product type r : regulator; DNA-binding transcriptional repressor of flagellar, motility and chemotaxis genes complement(2603302..2604240) Escherichia coli 55989 7147043 YP_002403556.1 CDS yfbQ NC_011748.1 2605160 2606377 D broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor; aminotransferase 2605160..2606377 Escherichia coli 55989 7146743 YP_002403557.1 CDS yfbR NC_011748.1 2606461 2607060 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489502; Product type e : enzyme; hypothetical protein 2606461..2607060 Escherichia coli 55989 7148699 YP_002403558.1 CDS yfbS NC_011748.1 2607119 2608951 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter complement(2607119..2608951) Escherichia coli 55989 7148700 YP_002403559.1 CDS yfbT NC_011748.1 2609038 2609688 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; phosphatase complement(2609038..2609688) Escherichia coli 55989 7148701 YP_002403560.1 CDS yfbU NC_011748.1 2609699 2610193 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2609699..2610193) Escherichia coli 55989 7148702 YP_002403561.1 CDS yfbV NC_011748.1 2610276 2610731 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(2610276..2610731) Escherichia coli 55989 7148703 YP_002403562.1 CDS ackA NC_011748.1 2611069 2612271 D AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA; acetate kinase 2611069..2612271 Escherichia coli 55989 7148704 YP_002403563.1 CDS pta NC_011748.1 2612346 2614490 D catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate; phosphate acetyltransferase 2612346..2614490 Escherichia coli 55989 7145437 YP_002403564.1 CDS yfcC NC_011748.1 2614680 2616200 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pc : carrier; hypothetical protein 2614680..2616200 Escherichia coli 55989 7147281 YP_002403565.1 CDS yfcD NC_011748.1 2616233 2616775 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16430214; Product type pe : enzyme; NUDIX hydrolase complement(2616233..2616775) Escherichia coli 55989 7148707 YP_002403566.1 CDS yfcE NC_011748.1 2616833 2617387 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; phosphodiesterase complement(2616833..2617387) Escherichia coli 55989 7148708 YP_002403567.1 CDS yfcF NC_011748.1 2617440 2618084 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein complement(2617440..2618084) Escherichia coli 55989 7148709 YP_002403568.1 CDS yfcG NC_011748.1 2618220 2618867 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; glutathione S-transferase 2618220..2618867 Escherichia coli 55989 7148710 YP_002403569.1 CDS folX NC_011748.1 2618924 2619286 D catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate; D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase 2618924..2619286 Escherichia coli 55989 7148711 YP_002403570.1 CDS yfcH NC_011748.1 2619307 2620200 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : enzyme; NAD(P)-binding Rossmann-fold domain 2619307..2620200 Escherichia coli 55989 7146176 YP_002403571.1 CDS yfcI NC_011748.1 2620248 2621150 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase complement(2620248..2621150) Escherichia coli 55989 7148712 YP_002403572.1 CDS hisP NC_011748.1 2621347 2622120 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284, 91060556; Product type t : transporter; histidine/lysine/arginine/ornithine transporter subunit complement(2621347..2622120) Escherichia coli 55989 7148713 YP_002403573.1 CDS hisM NC_011748.1 2622128 2622844 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 3313284; Product type t : transporter; histidine/lysine/arginine/ornithine transporter subunit ; membrane component of ABC superfamily complement(2622128..2622844) Escherichia coli 55989 7146441 YP_002403574.1 CDS hisQ NC_011748.1 2622841 2623527 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434; Product type t : transporter; histidine/lysine/arginine/ornithine transporter subunit ; membrane component of ABC superfamily complement(2622841..2623527) Escherichia coli 55989 7146440 YP_002403575.1 CDS hisJ NC_011748.1 2623617 2624399 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10373434, 6449635, 8161536, 9298646, 9600841, 9740056; Product type t : transporter; histidine/lysine/arginine/ornithine transporter subunit ; periplasmic-binding component of ABC superfamily complement(2623617..2624399) Escherichia coli 55989 7146442 YP_002403576.1 CDS argT NC_011748.1 2624620 2625402 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4583243, 87308226, 3040734, 9298646; Product type t : transporter; lysine/arginine/ornithine transporter subunit ; periplasmic-binding component of ABC superfamily complement(2624620..2625402) Escherichia coli 55989 7146438 YP_002403577.1 CDS ubiX NC_011748.1 2625668 2626237 R catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase complement(2625668..2626237) Escherichia coli 55989 7145537 YP_002403578.1 CDS purF NC_011748.1 2626332 2627849 R Catalyzes first step of the de novo purine nucleotide biosynthetic pathway; amidophosphoribosyltransferase complement(2626332..2627849) Escherichia coli 55989 7147895 YP_002403579.1 CDS cvpA NC_011748.1 2627886 2628374 R membrane protein required for colicin V production; colicin V production protein complement(2627886..2628374) Escherichia coli 55989 7147297 YP_002403580.1 CDS dedD NC_011748.1 2628633 2629295 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3040734; hypothetical protein complement(2628633..2629295) Escherichia coli 55989 7145800 YP_002403581.1 CDS folC NC_011748.1 2629285 2630553 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3040739, 91112811, 92041808, 1989505, 3040734; Product type e : enzyme; bifunctional folylpolyglutamate synthase/ dihydrofolate synthase complement(2629285..2630553) Escherichia coli 55989 7145877 YP_002403582.1 CDS accD NC_011748.1 2630623 2631537 R catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits; acetyl-CoA carboxylase subunit beta complement(2630623..2631537) Escherichia coli 55989 7146170 YP_002403583.1 CDS dedA NC_011748.1 2631693 2632352 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3029016, 3040734, 7678242; Product type pm : membrane component; hypothetical protein complement(2631693..2632352) Escherichia coli 55989 7145431 YP_002403584.1 CDS truA NC_011748.1 2632435 2633247 R mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability; tRNA pseudouridine synthase A complement(2632435..2633247) Escherichia coli 55989 7145876 YP_002403585.1 CDS usg NC_011748.1 2633247 2634260 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 92380957, 92380982, 93123150, 2681152, 2991861, 3029016; Product type pe : enzyme; semialdehyde dehydrogenase complement(2633247..2634260) Escherichia coli 55989 7147858 YP_002403586.1 CDS pdxB NC_011748.1 2634326 2635462 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90036695, 91035267, 2681152, 2991861, 3029016; Product type e : enzyme; erythronate-4-phosphate dehydrogenase complement(2634326..2635462) Escherichia coli 55989 7147926 YP_002403587.1 CDS flk NC_011748.1 2635561 2636556 D in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein; flagella biosynthesis regulator 2635561..2636556 Escherichia coli 55989 7147125 YP_002403588.1 CDS yfcJ NC_011748.1 2636553 2637731 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; hypothetical protein complement(2636553..2637731) Escherichia coli 55989 7146162 YP_002403589.1 CDS fabB NC_011748.1 2638024 2639244 R FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP; 3-oxoacyl-ACP synthase complement(2638024..2639244) Escherichia coli 55989 7148714 YP_002403590.1 CDS mnmC NC_011748.1 2639403 2641409 D catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules; 5-methylaminomethyl-2-thiouridine methyltransferase 2639403..2641409 Escherichia coli 55989 7146047 YP_002403591.1 CDS yfcL NC_011748.1 2641530 2641808 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2641530..2641808) Escherichia coli 55989 7147845 YP_002403592.1 CDS yfcM NC_011748.1 2641842 2642390 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2641842..2642390) Escherichia coli 55989 7148715 YP_002403593.1 CDS yfcA NC_011748.1 2642390 2643199 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(2642390..2643199) Escherichia coli 55989 7148716 YP_002403594.1 CDS mepA NC_011748.1 2643199 2644023 R D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm; penicillin-insensitive murein endopeptidase complement(2643199..2644023) Escherichia coli 55989 7148706 YP_002403595.1 CDS aroC NC_011748.1 2644027 2645112 R catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis; chorismate synthase complement(2644027..2645112) Escherichia coli 55989 7146823 YP_002403596.1 CDS prmB NC_011748.1 2645147 2646079 R involved in methylation of ribosomal protein L3; N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase complement(2645147..2646079) Escherichia coli 55989 7145541 YP_002403597.1 CDS yfcN NC_011748.1 2646245 2646796 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2646245..2646796 Escherichia coli 55989 7147250 YP_002403598.1 CDS EC55989_2576 NC_011748.1 2646990 2647970 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family complement(2646990..2647970) Escherichia coli 55989 7148717 YP_002403599.1 CDS EC55989_2577 NC_011748.1 2648197 2649069 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2648197..2649069) Escherichia coli 55989 7144776 YP_002403600.1 CDS EC55989_2578 NC_011748.1 2649056 2649580 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial protein (Adhesin) complement(2649056..2649580) Escherichia coli 55989 7144777 YP_002403601.1 CDS EC55989_2579 NC_011748.1 2649577 2650047 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial protein complement(2649577..2650047) Escherichia coli 55989 7144778 YP_002403602.1 CDS EC55989_2580 NC_011748.1 2650044 2650658 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; minor fimbrial subunit complement(2650044..2650658) Escherichia coli 55989 7144779 YP_002403603.1 CDS yfcS NC_011748.1 2650567 2651319 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; periplasmic pilus chaperone complement(2650567..2651319) Escherichia coli 55989 7144780 YP_002403604.1 CDS EC55989_2582 NC_011748.1 2651339 2653981 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; outer membrane usher protein yfcU precursor complement(2651339..2653981) Escherichia coli 55989 7148718 YP_002403605.1 CDS yfcV NC_011748.1 2654063 2654626 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein complement(2654063..2654626) Escherichia coli 55989 7144781 YP_002403606.1 CDS sixA NC_011748.1 2655301 2655786 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10089421, 20200300, 9489669; Product type e : enzyme; phosphohistidine phosphatase complement(2655301..2655786) Escherichia coli 55989 7148719 YP_002403607.1 CDS fadJ NC_011748.1 2655989 2658133 R multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate; multifunctional fatty acid oxidation complex subunit alpha complement(2655989..2658133) Escherichia coli 55989 7147659 YP_002403608.1 CDS fadI NC_011748.1 2658133 2659443 R FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth; 3-ketoacyl-CoA thiolase complement(2658133..2659443) Escherichia coli 55989 7148720 YP_002403609.1 CDS yfcZ NC_011748.1 2659623 2659907 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2659623..2659907) Escherichia coli 55989 7148721 YP_002403610.1 CDS fadL NC_011748.1 2660273 2661619 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15178802, 2840553, 3286621, 91100327, 1987139, 9119048; Product type t : transporter; long-chain fatty acid outer membrane transporter 2660273..2661619 Escherichia coli 55989 7148722 YP_002403611.1 CDS yfdF NC_011748.1 2661985 2663043 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2661985..2663043 Escherichia coli 55989 7146060 YP_002403612.1 CDS vacJ NC_011748.1 2663225 2663980 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8145644, 15352239; Product type lp : lipoprotein; lipoprotein complement(2663225..2663980) Escherichia coli 55989 7148725 YP_002403613.1 CDS EC55989_2591 NC_011748.1 2664006 2664176 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2664006..2664176) Escherichia coli 55989 7147945 YP_002403614.1 CDS yfdC NC_011748.1 2664274 2665206 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2664274..2665206 Escherichia coli 55989 7144782 YP_002403615.1 CDS intS NC_011748.1 2665518 2666675 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; prophage CPS-53 integrase; CPS-53 (KpLE1) prophage 2665518..2666675 Escherichia coli 55989 7145335 YP_002403616.1 CDS EC55989_2594 NC_011748.1 2666884 2668806 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2666884..2668806 Escherichia coli 55989 7146610 YP_002403617.1 CDS EC55989_2595 NC_011748.1 2668877 2670856 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein; head-binding domain complement(2668877..2670856) Escherichia coli 55989 7144783 YP_002403618.1 CDS EC55989_2596 NC_011748.1 2670908 2671246 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; regulatory protein mnt (modular protein) 2670908..2671246 Escherichia coli 55989 7144784 YP_002403619.1 CDS EC55989_2597 NC_011748.1 2671482 2672261 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2671482..2672261) Escherichia coli 55989 7144785 YP_002403620.1 CDS EC55989_2598 NC_011748.1 2672299 2673009 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2672299..2673009) Escherichia coli 55989 7144786 YP_002403621.1 CDS EC55989_2599 NC_011748.1 2672999 2673187 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; transcriptional repressor arc (modular protein) complement(2672999..2673187) Escherichia coli 55989 7144787 YP_002403622.1 CDS EC55989_2600 NC_011748.1 2673284 2673604 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; regulator protein; Arc-like DNA binding domain 2673284..2673604 Escherichia coli 55989 7144788 YP_002403623.1 CDS EC55989_2601 NC_011748.1 2673688 2673882 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2673688..2673882 Escherichia coli 55989 7144789 YP_002403624.1 CDS EC55989_2602 NC_011748.1 2673896 2674261 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2673896..2674261) Escherichia coli 55989 7144790 YP_002403625.1 CDS gp NC_011748.1 2676624 2677967 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA transfer protein gp20 complement(2676624..2677967) Escherichia coli 55989 7144792 YP_002403626.1 CDS EC55989_2605 NC_011748.1 2677978 2678670 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA transfer protein complement(2677978..2678670) Escherichia coli 55989 7146357 YP_002403627.1 CDS EC55989_2606 NC_011748.1 2678673 2679131 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Head assembly protein complement(2678673..2679131) Escherichia coli 55989 7144793 YP_002403628.1 CDS GP NC_011748.1 2679128 2679976 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Packaged DNA stabilization protein gp26 complement(2679128..2679976) Escherichia coli 55989 7144794 YP_002403629.1 CDS EC55989_2608 NC_011748.1 2679976 2681394 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Packaged DNA stabilization protein from phage complement(2679976..2681394) Escherichia coli 55989 7146358 YP_002403630.1 CDS EC55989_2609 NC_011748.1 2681403 2681885 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; packaged DNA stabilization protein p27 complement(2681403..2681885) Escherichia coli 55989 7144795 YP_002403631.1 CDS EC55989_2610 NC_011748.1 2681860 2682045 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein complement(2681860..2682045) Escherichia coli 55989 7144796 YP_002403632.1 CDS p NC_011748.1 2682088 2683359 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Major head protein (p24) (Major coat protein) complement(2682088..2683359) Escherichia coli 55989 7144797 YP_002403633.1 CDS EC55989_2612 NC_011748.1 2683371 2684255 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; scaffold protein complement(2683371..2684255) Escherichia coli 55989 7147091 YP_002403634.1 CDS EC55989_2613 NC_011748.1 2684269 2686467 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; portal protein p19 complement(2684269..2686467) Escherichia coli 55989 7144798 YP_002403635.1 CDS EC55989_2614 NC_011748.1 2686398 2687810 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Terminase large subunit complement(2686398..2687810) Escherichia coli 55989 7144799 YP_002403636.1 CDS EC55989_2615 NC_011748.1 2687807 2688232 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; terminase small subunit complement(2687807..2688232) Escherichia coli 55989 7144800 YP_002403637.1 CDS EC55989_2616 NC_011748.1 2688312 2688554 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2688312..2688554) Escherichia coli 55989 7144801 YP_002403638.1 CDS EC55989_2617 NC_011748.1 2688658 2689038 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein complement(2688658..2689038) Escherichia coli 55989 7144802 YP_002403639.1 CDS EC55989_2618 NC_011748.1 2689272 2689751 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2689272..2689751) Escherichia coli 55989 7144803 YP_002403640.1 CDS EC55989_2619 NC_011748.1 2689973 2690422 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; bacteriophage lysis protein complement(2689973..2690422) Escherichia coli 55989 7144804 YP_002403641.1 CDS ybcS NC_011748.1 2690407 2690904 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3017988; Product type pe : enzyme; lysozyme; DLP12 prophage complement(2690407..2690904) Escherichia coli 55989 7144805 YP_002403642.1 CDS EC55989_2621 NC_011748.1 2690882 2691085 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2690882..2691085) Escherichia coli 55989 7148136 YP_002403643.1 CDS EC55989_2624 NC_011748.1 2691570 2691842 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 2691570..2691842 Escherichia coli 55989 7144807 YP_002403644.1 CDS EC55989_2625 NC_011748.1 2691876 2692364 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; phage antitermination protein Q complement(2691876..2692364) Escherichia coli 55989 7144808 YP_002403645.1 CDS rusA NC_011748.1 2692546 2692908 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; crossover junction endodeoxyribonuclease complement(2692546..2692908) Escherichia coli 55989 7144809 YP_002403646.1 CDS EC55989_2627 NC_011748.1 2692905 2693195 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2692905..2693195) Escherichia coli 55989 7147560 YP_002403647.1 CDS roi NC_011748.1 2693195 2693917 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA-binding protein from phage origin complement(2693195..2693917) Escherichia coli 55989 7144810 YP_002403648.1 CDS ninF NC_011748.1 2693910 2694080 R Evidence 4 : Homologs of previously reported genes of unknown function; phage protein complement(2693910..2694080) Escherichia coli 55989 7147459 YP_002403649.1 CDS EC55989_2630 NC_011748.1 2694256 2694666 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; ninB protein complement(2694256..2694666) Escherichia coli 55989 7147002 YP_002403650.1 CDS EC55989_2631 NC_011748.1 2694866 2695180 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein complement(2694866..2695180) Escherichia coli 55989 7144811 YP_002403651.1 CDS EC55989_2632 NC_011748.1 2695198 2695404 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; phage protein complement(2695198..2695404) Escherichia coli 55989 7144812 YP_002403652.1 CDS P NC_011748.1 2695480 2696931 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; P protein; replicative DNA helicase complement(2695480..2696931) Escherichia coli 55989 7144813 YP_002403653.1 CDS O NC_011748.1 2696906 2697796 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; replication protein O complement(2696906..2697796) Escherichia coli 55989 7147092 YP_002403654.1 CDS EC55989_2635 NC_011748.1 2697783 2697944 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2697783..2697944) Escherichia coli 55989 7147062 YP_002403655.1 CDS C NC_011748.1 2697979 2698344 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Transcriptional activator protein C1 (modular protein) complement(2697979..2698344) Escherichia coli 55989 7144814 YP_002403656.1 CDS cro NC_011748.1 2698366 2698551 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Regulatory protein cro (Antirepressor) complement(2698366..2698551) Escherichia coli 55989 7145646 YP_002403657.1 CDS cII NC_011748.1 2698632 2699282 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Repressor protein CII 2698632..2699282 Escherichia coli 55989 7145759 YP_002403658.1 CDS EC55989_2639 NC_011748.1 2699454 2699639 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2699454..2699639) Escherichia coli 55989 7145707 YP_002403659.1 CDS EC55989_2641 NC_011748.1 2700362 2700832 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2700362..2700832 Escherichia coli 55989 7146940 YP_002403660.1 CDS EC55989_2642 NC_011748.1 2700922 2701197 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2700922..2701197 Escherichia coli 55989 7144816 YP_002403661.1 CDS EC55989_2643 NC_011748.1 2701164 2701364 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2701164..2701364 Escherichia coli 55989 7144817 YP_002403662.1 CDS EC55989_2644 NC_011748.1 2701273 2701443 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2701273..2701443 Escherichia coli 55989 7144818 YP_002403663.1 CDS erf NC_011748.1 2701424 2702059 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; DNA single-strand annealing protein; essential recombination function protein Erf 2701424..2702059 Escherichia coli 55989 7144819 YP_002403664.1 CDS EC55989_2646 NC_011748.1 2701969 2702442 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2701969..2702442 Escherichia coli 55989 7146021 YP_002403665.1 CDS abc NC_011748.1 2702466 2702762 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Anti-RecBCD protein 2 2702466..2702762 Escherichia coli 55989 7144820 YP_002403666.1 CDS EC55989_2649 NC_011748.1 2703224 2703895 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; EA22-like protein; similarities with EA22 from lambda (modular protein involved in blocking host replication) 2703224..2703895 Escherichia coli 55989 7144821 YP_002403667.1 CDS EC55989_2650 NC_011748.1 2704068 2704256 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; prophage protein 2704068..2704256 Escherichia coli 55989 7144822 YP_002403668.1 CDS EC55989_2651 NC_011748.1 2704258 2704467 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; prophage protein 2704258..2704467 Escherichia coli 55989 7144823 YP_002403669.1 CDS EC55989_2652 NC_011748.1 2704464 2705093 D Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; prophage protein (fragment) 2704464..2705093 Escherichia coli 55989 7144824 YP_002403670.1 CDS torI NC_011748.1 2705501 2705701 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15197250; Product type r : regulator; response regulator inhibitor for tor operon 2705501..2705701 Escherichia coli 55989 7144825 YP_002403671.1 CDS lacY NC_011748.1 2706231 2707478 R lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments; galactoside permease complement(2706231..2707478) Escherichia coli 55989 7147823 YP_002403672.1 CDS cscK NC_011748.1 2707550 2708464 R phosphorylates aminoimidazole ribotide (AIR) which forms 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate (HMP-P); synthesis of HMP-P from AIR is complex and requires the product of thiC gene at least; aminoimidazole riboside kinase complement(2707550..2708464) Escherichia coli 55989 7145764 YP_002403673.1 CDS cscA NC_011748.1 2708671 2710113 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12218016; Product type e : enzyme; sucrose-6-phosphate hydrolase 2708671..2710113 Escherichia coli 55989 7145765 YP_002403674.1 CDS cscR NC_011748.1 2710121 2711302 R Evidence 2b : Function of strongly homologous gene; Product type r : regulator; Sucrose operon repressor (Csc operon regulatory protein) complement(2710121..2711302) Escherichia coli 55989 7145763 YP_002403675.1 CDS dsdA NC_011748.1 2711583 2712911 D catalyzes the formation of pyruvate from serine; D-serine dehydratase 2711583..2712911 Escherichia coli 55989 7145955 YP_002403676.1 CDS emrY NC_011748.1 2713019 2714557 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20378313; Product type pt : transporter; multidrug efflux system complement(2713019..2714557) Escherichia coli 55989 7145954 YP_002403677.1 CDS emrK NC_011748.1 2714557 2715720 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20378313; Product type t : transporter; EmrKY-TolC multidrug resistance efflux pump, membrane fusion protein component complement(2714557..2715720) Escherichia coli 55989 7145995 YP_002403678.1 CDS evgA NC_011748.1 2716136 2716750 D response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance; DNA-binding transcriptional activator EvgA 2716136..2716750 Escherichia coli 55989 7145994 YP_002403679.1 CDS evgS NC_011748.1 2716755 2720348 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14523115, 93173621, 9501520, 10923791, 1289796, 8125343, 9535079; Product type r : regulator; hybrid sensory histidine kinase in two-component regulatory system with EvgA 2716755..2720348 Escherichia coli 55989 7146038 YP_002403680.1 CDS yfdE NC_011748.1 2720404 2721549 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein complement(2720404..2721549) Escherichia coli 55989 7146039 YP_002403681.1 CDS yfdV NC_011748.1 2721623 2722567 R member of the AEC family of auxin efflux transporters; unknown function; transporter YfdV complement(2721623..2722567) Escherichia coli 55989 7148724 YP_002403682.1 CDS oxc NC_011748.1 2722637 2724331 R catalyzes the formation of formyl-CoA from oxalyl-CoA; oxalyl-CoA decarboxylase complement(2722637..2724331) Escherichia coli 55989 7148726 YP_002403683.1 CDS frc NC_011748.1 2724385 2725635 R catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA; formyl-coenzyme A transferase complement(2724385..2725635) Escherichia coli 55989 7147087 YP_002403684.1 CDS yfdX NC_011748.1 2726148 2726780 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11157960; hypothetical protein complement(2726148..2726780) Escherichia coli 55989 7146178 YP_002403685.1 CDS ypdI NC_011748.1 2727076 2727351 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15183873; Product type lp : lipoprotein; lipoprotein 2727076..2727351 Escherichia coli 55989 7148727 YP_002403686.1 CDS yfdY NC_011748.1 2727428 2727670 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14727089; Product type pm : membrane component; inner membrane protein complement(2727428..2727670) Escherichia coli 55989 7149370 YP_002403688.1 CDS ddg NC_011748.1 2728023 2728943 D Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock; lipid A biosynthesis palmitoleoyl acyltransferase 2728023..2728943 Escherichia coli 55989 7144826 YP_002403689.1 CDS yfdZ NC_011748.1 2729435 2730673 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; aminotransferase complement(2729435..2730673) Escherichia coli 55989 7147832 YP_002403690.1 CDS ypdA NC_011748.1 2731050 2732747 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type prc : receptor; sensory kinase in two-component system with YpdB 2731050..2732747 Escherichia coli 55989 7148729 YP_002403691.1 CDS ypdB NC_011748.1 2732762 2733496 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15522865; Product type pr : regulator; response regulator in two-component system with YpdA 2732762..2733496 Escherichia coli 55989 7149362 YP_002403692.1 CDS ypdC NC_011748.1 2733509 2734366 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding protein 2733509..2734366 Escherichia coli 55989 7149363 YP_002403693.1 CDS ypdD NC_011748.1 2734369 2736864 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; fused PTS enzymes (multiphosphoryl transfer protein): Hpr component ; enzyme I component ; enzyme IIA component complement(2734369..2736864) Escherichia coli 55989 7149364 YP_002403694.1 CDS ypdE NC_011748.1 2736889 2737926 R metalloprotein; exoaminopeptidase complement(2736889..2737926) Escherichia coli 55989 7149365 YP_002403695.1 CDS ypdF NC_011748.1 2737926 2739011 R Xaa-Pro aminopeptidase; limited methionine aminopeptidase; aminopeptidase complement(2737926..2739011) Escherichia coli 55989 7149366 YP_002403696.1 CDS ypdG NC_011748.1 2739026 2740273 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; enzyme IIC component of PTS complement(2739026..2740273) Escherichia coli 55989 7149367 YP_002403697.1 CDS ypdH NC_011748.1 2740295 2740621 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; enzyme IIB component of PTS complement(2740295..2740621) Escherichia coli 55989 7149368 YP_002403698.1 CDS glk NC_011748.1 2740840 2741805 R catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate; glucokinase complement(2740840..2741805) Escherichia coli 55989 7149369 YP_002403699.1 CDS yfeO NC_011748.1 2742009 2743265 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; hypothetical protein 2742009..2743265 Escherichia coli 55989 7146298 YP_002403700.1 CDS ypeC NC_011748.1 2743380 2743706 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2743380..2743706 Escherichia coli 55989 7148737 YP_002403701.1 CDS mntH NC_011748.1 2743847 2745085 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20177822, 20305051, 10712688, 10844693; Product type t : transporter; manganese transport protein MntH complement(2743847..2745085) Escherichia coli 55989 7149373 YP_002403702.1 CDS nupC NC_011748.1 2745421 2746623 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 374403, 8022285, 7007808, 827549, 4563236, 1512211; Product type t : transporter; nucleoside (except guanosine) transporter 2745421..2746623 Escherichia coli 55989 7146870 YP_002403703.1 CDS yfeA NC_011748.1 2746673 2748862 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; diguanylate cyclase complement(2746673..2748862) Escherichia coli 55989 7147056 YP_002403704.1 CDS yfeC NC_011748.1 2749496 2749840 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; nucleic acid-binding transcriptional regulator 2749496..2749840 Escherichia coli 55989 7145388 YP_002403705.1 CDS yfeD NC_011748.1 2749842 2750234 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; nucleic acid-binding transcriptional regulator 2749842..2750234 Escherichia coli 55989 7148731 YP_002403706.1 CDS gltX NC_011748.1 2750286 2751701 R Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation; glutamyl-tRNA synthetase complement(2750286..2751701) Escherichia coli 55989 7148732 YP_002403707.1 CDS xapR NC_011748.1 2752622 2753506 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10400599, 7007808, 2201776, 7559336; Product type r : regulator; DNA-binding transcriptional activator XapR complement(2752622..2753506) Escherichia coli 55989 7145340 YP_002403708.1 CDS xapB NC_011748.1 2753758 2755014 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96032385, 7559336; Product type t : transporter; xanthosine transporter complement(2753758..2755014) Escherichia coli 55989 7147984 YP_002403709.1 CDS xapA NC_011748.1 2755074 2755907 R catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation; purine nucleoside phosphorylase complement(2755074..2755907) Escherichia coli 55989 7147983 YP_002403710.1 CDS yfeN NC_011748.1 2756156 2756920 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; hypothetical protein 2756156..2756920 Escherichia coli 55989 7147982 YP_002403711.1 CDS yfeR NC_011748.1 2756959 2757885 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(2756959..2757885) Escherichia coli 55989 7148736 YP_002403712.1 CDS yfeH NC_011748.1 2757975 2758973 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; sodium/bile acid symporter family (mazG-like) 2757975..2758973 Escherichia coli 55989 7148738 YP_002403713.1 CDS ypeB NC_011748.1 2758970 2759188 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2758970..2759188) Escherichia coli 55989 7148734 YP_002403714.1 CDS ligA NC_011748.1 2759190 2761205 R this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB; NAD-dependent DNA ligase LigA complement(2759190..2761205) Escherichia coli 55989 7149372 YP_002403715.1 CDS zipA NC_011748.1 2761276 2762262 R interacts with cell division protein FitsZ and may be required to anchor septal ring structure; cell division protein ZipA complement(2761276..2762262) Escherichia coli 55989 7146700 YP_002403716.1 CDS cysZ NC_011748.1 2762492 2763253 D role in sulfur assimilation; sulfate transport protein CysZ 2762492..2763253 Escherichia coli 55989 7149488 YP_002403717.1 CDS cysK NC_011748.1 2763438 2764409 D CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis; cysteine synthase A 2763438..2764409 Escherichia coli 55989 7145837 YP_002403718.1 CDS ptsH NC_011748.1 2764793 2765050 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type t : transporter; PTS system phosphohistidinoprotein-hexose phosphotransferase Hpr 2764793..2765050 Escherichia coli 55989 7145829 YP_002403719.1 CDS ptsI NC_011748.1 2765095 2766822 D Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system; phosphoenolpyruvate-protein phosphotransferase 2765095..2766822 Escherichia coli 55989 7147288 YP_002403720.1 CDS crr NC_011748.1 2766863 2767372 D functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose; PTS system glucose-specific transporter 2766863..2767372 Escherichia coli 55989 7147289 YP_002403721.1 CDS pdxK NC_011748.1 2767414 2768265 R catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal; pyridoxal kinase complement(2767414..2768265) Escherichia coli 55989 7145762 YP_002403722.1 CDS yfeK NC_011748.1 2768370 2768738 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2768370..2768738 Escherichia coli 55989 7147128 YP_002403723.1 CDS cysM NC_011748.1 2768741 2769652 R catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide; cysteine synthase B complement(2768741..2769652) Escherichia coli 55989 7148735 YP_002403724.1 CDS cysA NC_011748.1 2769786 2770883 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 90264334, 2188958, 7665461; Product type t : transporter; sulfate/thiosulfate transporter subunit complement(2769786..2770883) Escherichia coli 55989 7145830 YP_002403725.1 CDS cysW NC_011748.1 2770873 2771748 R Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import; sulfate/thiosulfate transporter permease subunit complement(2770873..2771748) Escherichia coli 55989 7145820 YP_002403726.1 CDS cysU NC_011748.1 2771748 2772581 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264334, 2188958; Product type t : transporter; sulfate/thiosulfate transporter subunit complement(2771748..2772581) Escherichia coli 55989 7145836 YP_002403727.1 CDS cysP NC_011748.1 2772581 2773597 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264335, 2188959, 9298646; Product type t : transporter; thiosulfate transporter subunit complement(2772581..2773597) Escherichia coli 55989 7145835 YP_002403728.1 CDS ucpA NC_011748.1 2773768 2774559 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 97385354, 2188959, 7984428, 9241368; Product type pe : enzyme; short chain dehydrogenase complement(2773768..2774559) Escherichia coli 55989 7145832 YP_002403729.1 CDS yfeT NC_011748.1 2774688 2775545 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(2774688..2775545) Escherichia coli 55989 7147896 YP_002403730.1 CDS murQ NC_011748.1 2775709 2776605 D catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway; N-acetylmuramic acid 6-phosphate etherase 2775709..2776605 Escherichia coli 55989 7148739 YP_002403731.1 CDS murP NC_011748.1 2776609 2778033 D belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component; PTS system N-acetylmuramic acid transporter subunit IIBC 2776609..2778033 Escherichia coli 55989 7148740 YP_002403732.1 CDS murQ NC_011748.1 2778038 2779342 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15983044, 15060041; Product type e : enzyme; hypothetical protein 2778038..2779342 Escherichia coli 55989 7146929 YP_002403733.1 CDS yfeX NC_011748.1 2779398 2780297 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2779398..2780297) Escherichia coli 55989 7146930 YP_002403734.1 CDS yfeY NC_011748.1 2780393 2780968 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12900013, 7764507; hypothetical protein complement(2780393..2780968) Escherichia coli 55989 7148741 YP_002403735.1 CDS yfeZ NC_011748.1 2781029 2781478 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(2781029..2781478) Escherichia coli 55989 7148742 YP_002403736.1 CDS ypeA NC_011748.1 2781465 2781890 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acetyltransferase complement(2781465..2781890) Escherichia coli 55989 7148743 YP_002403737.1 CDS amiA NC_011748.1 2782104 2782973 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 6137479, 87242501, 1903834, 8300522; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase I 2782104..2782973 Escherichia coli 55989 7149371 YP_002403738.1 CDS hemF NC_011748.1 2782977 2783876 D catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis; coproporphyrinogen III oxidase 2782977..2783876 Escherichia coli 55989 7145490 YP_002403739.1 CDS yfeG NC_011748.1 2783882 2784934 R activates the transcription of the ethanolamine utilization operon; transcriptional regulator EutR complement(2783882..2784934) Escherichia coli 55989 7146412 YP_002403740.1 CDS yffI NC_011748.1 2784980 2785480 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10464203; Product type ps : structure; ethanolaminosome structural protein with role in ethanolamine utilization complement(2784980..2785480) Escherichia coli 55989 7148733 YP_002403741.1 CDS eutL NC_011748.1 2785493 2786152 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : structure; carboxysome-related structural protein with role in ethanolamine utilization complement(2785493..2786152) Escherichia coli 55989 7148746 YP_002403742.1 CDS eutC NC_011748.1 2786162 2787049 R catalyzes the formation of acetaldehyde from ethanolamine; ethanolamine ammonia-lyase small subunit complement(2786162..2787049) Escherichia coli 55989 7146034 YP_002403743.1 CDS eutB NC_011748.1 2787070 2788431 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3905806, 10464203; Product type e : enzyme; ethanolamine ammonia-lyase, large subunit, heavy chain complement(2787070..2788431) Escherichia coli 55989 7146028 YP_002403744.1 CDS eutA NC_011748.1 2788443 2789846 R ethanolamine utilization protein EutA; reactivating factor for ethanolamine ammonia lyase complement(2788443..2789846) Escherichia coli 55989 7146027 YP_002403745.1 CDS eutH NC_011748.1 2789843 2791069 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7868611, 10464203; Product type pt : transporter; ethanolamine transporter complement(2789843..2791069) Escherichia coli 55989 7146026 YP_002403746.1 CDS eutG NC_011748.1 2791386 2792573 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : enzyme; alcohol dehydrogenase in ethanolamine utilization; ethanolaminosome complement(2791386..2792573) Escherichia coli 55989 7146031 YP_002403747.1 CDS eutJ NC_011748.1 2792563 2793399 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pf : factor; chaperonin, ethanolamine utilization protein complement(2792563..2793399) Escherichia coli 55989 7146030 YP_002403748.1 CDS eutE NC_011748.1 2793410 2794813 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : enzyme; aldehyde dehydrogenase, ethanolamine utilization protein complement(2793410..2794813) Escherichia coli 55989 7146033 YP_002403749.1 CDS cchB NC_011748.1 2794825 2795112 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : structure; carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein complement(2794825..2795112) Escherichia coli 55989 7146029 YP_002403750.1 CDS cchA NC_011748.1 2795219 2795512 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : structure; carboxysome-like ethanolaminosome structural protein, ethanolamine utilization protein complement(2795219..2795512) Escherichia coli 55989 7145673 YP_002403751.1 CDS eutD NC_011748.1 2795551 2796567 R in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta; phosphotransacetylase complement(2795551..2796567) Escherichia coli 55989 7145672 YP_002403752.1 CDS eutT NC_011748.1 2796564 2797367 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : enzyme; cobalamin adenosyltransferase in ethanolamine utilization complement(2796564..2797367) Escherichia coli 55989 7146032 YP_002403753.1 CDS eutQ NC_011748.1 2797364 2798065 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10464203; hypothetical protein complement(2797364..2798065) Escherichia coli 55989 7146037 YP_002403754.1 CDS eutP NC_011748.1 2798040 2798519 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type pe : enzyme; nucleoside triphosphate hydrolase domain protein complement(2798040..2798519) Escherichia coli 55989 7146036 YP_002403755.1 CDS ypfE NC_011748.1 2798532 2798867 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16291677, 10464203; Product type ps : structure; carboxysome-like ethanolaminosome structural protein with role in ethanol utilization complement(2798532..2798867) Escherichia coli 55989 7146035 YP_002403756.1 CDS maeB NC_011748.1 2799160 2801439 R NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate; malic enzyme complement(2799160..2801439) Escherichia coli 55989 7149374 YP_002403757.1 CDS talA NC_011748.1 2801728 2802678 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90230300; Product type e : enzyme; transaldolase A 2801728..2802678 Escherichia coli 55989 7146766 YP_002403758.1 CDS tktB NC_011748.1 2802698 2804701 D catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase 2802698..2804701 Escherichia coli 55989 7147747 YP_002403759.1 CDS ypfG NC_011748.1 2804797 2805840 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2804797..2805840) Escherichia coli 55989 7147805 YP_002403760.1 CDS yffH NC_011748.1 2805966 2806541 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; NUDIX hydrolase complement(2805966..2806541) Escherichia coli 55989 7149375 YP_002403761.1 CDS aegA NC_011748.1 2806609 2808588 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit complement(2806609..2808588) Escherichia coli 55989 7148745 YP_002403762.1 CDS narQ NC_011748.1 2808794 2810494 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92374842, 1508040, 1528845; Product type r : regulator; nitrate/nitrite sensor protein NarQ 2808794..2810494 Escherichia coli 55989 7145462 YP_002403763.1 CDS acrD NC_011748.1 2810658 2813771 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12426336, 20158894, 21450803, 79216220, 10692383, 1644752; Product type t : transporter; aminoglycoside/multidrug efflux system 2810658..2813771 Escherichia coli 55989 7146974 YP_002403764.1 CDS yffB NC_011748.1 2814310 2814666 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2814310..2814666 Escherichia coli 55989 7145446 YP_002403765.1 CDS dapE NC_011748.1 2814670 2815797 D dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.; succinyl-diaminopimelate desuccinylase 2814670..2815797 Escherichia coli 55989 7148744 YP_002403766.1 CDS ypfN NC_011748.1 2815825 2816025 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2815825..2816025 Escherichia coli 55989 7145852 YP_002403767.1 CDS ypfH NC_011748.1 2816135 2816833 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YpfH complement(2816135..2816833) Escherichia coli 55989 7149379 YP_002403768.1 CDS ypfI NC_011748.1 2816907 2818922 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase complement(2816907..2818922) Escherichia coli 55989 7149376 YP_002403769.1 CDS ypfJ NC_011748.1 2818937 2819800 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2818937..2819800) Escherichia coli 55989 7149377 YP_002403770.1 CDS EC55989_2757 NC_011748.1 2819947 2820345 R stability determinant protein; plasmid maintenance protein complement(2819947..2820345) Escherichia coli 55989 7149378 YP_002403771.1 CDS EC55989_2758 NC_011748.1 2820345 2820611 R Evidence 4 : Homologs of previously reported genes of unknown function; transcriptionnal regulation protein complement(2820345..2820611) Escherichia coli 55989 7144827 YP_002403772.1 CDS purC NC_011748.1 2820727 2821440 R catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase; phosphoribosylaminoimidazole-succinocarboxamide synthase complement(2820727..2821440) Escherichia coli 55989 7144828 YP_002403773.1 CDS nlpB NC_011748.1 2821653 2822687 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91358331, 1885529, 2120198; Product type lp : lipoprotein; lipoprotein complement(2821653..2822687) Escherichia coli 55989 7147294 YP_002403774.1 CDS dapA NC_011748.1 2822704 2823582 R catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis; dihydrodipicolinate synthase complement(2822704..2823582) Escherichia coli 55989 7147007 YP_002403775.1 CDS gcvR NC_011748.1 2823728 2824300 D negative transcriptional regulator of the gcvTHP operon; glycine cleavage system transcriptional repressor 2823728..2824300 Escherichia coli 55989 7145849 YP_002403776.1 CDS bcp NC_011748.1 2824300 2824770 D bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine; thioredoxin-dependent thiol peroxidase 2824300..2824770 Escherichia coli 55989 7146278 YP_002403777.1 CDS hyfA NC_011748.1 2825023 2825640 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241, 2016588; Product type c : carrier; hydrogenase 4, 4Fe-4S subunit 2825023..2825640 Escherichia coli 55989 7145600 YP_002403778.1 CDS hyfB NC_011748.1 2825640 2827658 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit B 2825640..2827658 Escherichia coli 55989 7146506 YP_002403779.1 CDS hyfE NC_011748.1 2830083 2830733 D interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide; hydrogenase 4 membrane subunit 2830083..2830733 Escherichia coli 55989 7146511 YP_002403780.1 CDS hyfF NC_011748.1 2830738 2832318 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type m : membrane component; hydrogenase 4 subunit F 2830738..2832318 Escherichia coli 55989 7146512 YP_002403781.1 CDS hyfG NC_011748.1 2832356 2834023 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type c : carrier; hydrogenase 4 subunit 2832356..2834023 Escherichia coli 55989 7146513 YP_002403782.1 CDS hyfH NC_011748.1 2834033 2834572 D probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far; hydrogenase 4 subunit H 2834033..2834572 Escherichia coli 55989 7146514 YP_002403783.1 CDS hyfI NC_011748.1 2834569 2835327 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type c : carrier; hydrogenase 4, Fe-S subunit 2834569..2835327 Escherichia coli 55989 7146515 YP_002403784.1 CDS hyfJ NC_011748.1 2835320 2835733 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9387241; Product type pf : factor; processing element hydrogenase 4 2835320..2835733 Escherichia coli 55989 7146516 YP_002403785.1 CDS hyfR NC_011748.1 2835763 2837775 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9387241; Product type r : regulator; DNA-binding transcriptional activator, formate sensing 2835763..2837775 Escherichia coli 55989 7146517 YP_002403786.1 CDS focB NC_011748.1 2837797 2838528 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9387241; Product type pt : transporter; formate transporter 2837797..2838528 Escherichia coli 55989 7146518 YP_002403787.1 CDS perM NC_011748.1 2838682 2839743 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; permease complement(2838682..2839743) Escherichia coli 55989 7146167 YP_002403788.1 CDS yfgC NC_011748.1 2839956 2841419 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; peptidase 2839956..2841419 Escherichia coli 55989 7147138 YP_002403789.1 CDS yfgD NC_011748.1 2841440 2841799 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase 2841440..2841799 Escherichia coli 55989 7148749 YP_002403790.1 CDS hda NC_011748.1 2841937 2842683 R controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP; DNA replication initiation factor complement(2841937..2842683) Escherichia coli 55989 7148750 YP_002403791.1 CDS uraA NC_011748.1 2842733 2844022 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8332529, 7721693; Product type t : transporter; uracil transporter complement(2842733..2844022) Escherichia coli 55989 7146400 YP_002403792.1 CDS upp NC_011748.1 2844108 2844734 R Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate; uracil phosphoribosyltransferase complement(2844108..2844734) Escherichia coli 55989 7147925 YP_002403793.1 CDS purM NC_011748.1 2845059 2846096 D catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis; phosphoribosylaminoimidazole synthetase 2845059..2846096 Escherichia coli 55989 7147924 YP_002403794.1 CDS purN NC_011748.1 2846096 2846734 D glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate; phosphoribosylglycinamide formyltransferase 2846096..2846734 Escherichia coli 55989 7147301 YP_002403795.1 CDS ppk NC_011748.1 2846905 2848971 D catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate; polyphosphate kinase 2846905..2848971 Escherichia coli 55989 7147302 YP_002403796.1 CDS ppx NC_011748.1 2848976 2850517 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93107072, 94025037, 94165003, 8212131, 8380170; Product type e : enzyme; exopolyphosphatase 2848976..2850517 Escherichia coli 55989 7147232 YP_002403797.1 CDS yfgF NC_011748.1 2850556 2852799 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(2850556..2852799) Escherichia coli 55989 7147235 YP_002403798.1 CDS EC55989_2789 NC_011748.1 2853016 2853306 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2853016..2853306) Escherichia coli 55989 7148751 YP_002403799.1 CDS yfgH NC_011748.1 2853653 2854171 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; outer membrane lipoprotein 2853653..2854171 Escherichia coli 55989 7144829 YP_002403800.1 CDS yfgI NC_011748.1 2854187 2854726 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2854187..2854726 Escherichia coli 55989 7148752 YP_002403801.1 CDS guaA NC_011748.1 2854819 2856396 R contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway; GMP synthase complement(2854819..2856396) Escherichia coli 55989 7148753 YP_002403802.1 CDS guaB NC_011748.1 2856465 2857931 R catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate; inosine 5'-monophosphate dehydrogenase complement(2856465..2857931) Escherichia coli 55989 7146378 YP_002403803.1 CDS xseA NC_011748.1 2858093 2859463 D bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides; exodeoxyribonuclease VII large subunit 2858093..2859463 Escherichia coli 55989 7146379 YP_002403804.1 CDS yfgJ NC_011748.1 2859460 2859675 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2859460..2859675) Escherichia coli 55989 7147992 YP_002403805.1 CDS engA NC_011748.1 2859744 2861216 R EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains; GTP-binding protein EngA complement(2859744..2861216) Escherichia coli 55989 7148754 YP_002403806.1 CDS yfgL NC_011748.1 2861334 2862512 R with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis; outer membrane protein assembly complex subunit YfgL complement(2861334..2862512) Escherichia coli 55989 7145892 YP_002403807.1 CDS yfgM NC_011748.1 2862523 2863143 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2862523..2863143) Escherichia coli 55989 7148755 YP_002403808.1 CDS hisS NC_011748.1 2863161 2864435 R catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG; histidyl-tRNA synthetase complement(2863161..2864435) Escherichia coli 55989 7148756 YP_002403809.1 CDS ispG NC_011748.1 2864546 2865664 R catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis; 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase complement(2864546..2865664) Escherichia coli 55989 7145309 YP_002403810.1 CDS yfgA NC_011748.1 2865691 2866704 R Evidence 4 : Homologs of previously reported genes of unknown function; cytoskeletal protein RodZ complement(2865691..2866704) Escherichia coli 55989 7146630 YP_002403811.1 CDS yfgB NC_011748.1 2866989 2868143 R 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance; ribosomal RNA large subunit methyltransferase N complement(2866989..2868143) Escherichia coli 55989 7148747 YP_002403812.1 CDS ndk NC_011748.1 2868293 2868724 R catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate; nucleoside diphosphate kinase complement(2868293..2868724) Escherichia coli 55989 7148748 YP_002403813.1 CDS pbpC NC_011748.1 2868873 2871185 R penicillin-insensitive transglycosylase/transpeptidase; penicillin-binding protein 1C complement(2868873..2871185) Escherichia coli 55989 7146982 YP_002403814.1 CDS yfhM NC_011748.1 2871186 2876147 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2871186..2876147) Escherichia coli 55989 7147118 YP_002403815.1 CDS sseA NC_011748.1 2876354 2877199 D catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds; 3-mercaptopyruvate sulfurtransferase 2876354..2877199 Escherichia coli 55989 7148765 YP_002403816.1 CDS sseB NC_011748.1 2877692 2878468 R enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I; enhanced serine sensitivity protein SseB complement(2877692..2878468) Escherichia coli 55989 7147581 YP_002403817.1 CDS pepB NC_011748.1 2878610 2879893 R catalyzes the removal of an N-terminal amino acid from a peptide or arylamide; aminopeptidase complement(2878610..2879893) Escherichia coli 55989 7147712 YP_002403818.1 CDS yfhJ NC_011748.1 2880071 2880271 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10393315; Product type pf : factor; hypothetical protein complement(2880071..2880271) Escherichia coli 55989 7147131 YP_002403819.1 CDS fdx NC_011748.1 2880283 2880618 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 20013001, 92283811, 94181532, 11551196, 1317854, 4375562, 8300516; Product type c : carrier; [2Fe-2S] ferredoxin complement(2880283..2880618) Escherichia coli 55989 7148762 YP_002403820.1 CDS hscA NC_011748.1 2880620 2882470 R involved in the maturation of iron-sulfur cluster-containing proteins; chaperone protein HscA complement(2880620..2882470) Escherichia coli 55989 7146076 YP_002403821.1 CDS hscB NC_011748.1 2882487 2883002 R J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins; co-chaperone HscB complement(2882487..2883002) Escherichia coli 55989 7146461 YP_002403822.1 CDS iscA NC_011748.1 2883098 2883421 R forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein; iron-sulfur cluster assembly protein complement(2883098..2883421) Escherichia coli 55989 7146462 YP_002403823.1 CDS iscU NC_011748.1 2883438 2883824 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10393315, 11994302, 15153099; Product type f : factor; scaffold protein complement(2883438..2883824) Escherichia coli 55989 7146620 YP_002403824.1 CDS iscS NC_011748.1 2883852 2885066 R catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis; cysteine desulfurase complement(2883852..2885066) Escherichia coli 55989 7146623 YP_002403825.1 CDS iscR NC_011748.1 2885178 2885666 R regulates the expression of the iscRSUA operon; DNA-binding transcriptional regulator IscR complement(2885178..2885666) Escherichia coli 55989 7146622 YP_002403826.1 CDS yfhQ NC_011748.1 2885936 2886676 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10393315; Product type pe : enzyme; methyltransferase complement(2885936..2886676) Escherichia coli 55989 7146621 YP_002403827.1 CDS suhB NC_011748.1 2886795 2887598 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6389495, 90202735, 95095968, 10747806, 2138605, 8002619; Product type e : enzyme; inositol monophosphatase 2886795..2887598 Escherichia coli 55989 7148766 YP_002403828.1 CDS yfhR NC_011748.1 2887716 2888597 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; peptidase 2887716..2888597 Escherichia coli 55989 7147738 YP_002403829.1 CDS csiE NC_011748.1 2888788 2890068 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95020540, 96154950; Product type cp : cell process; stationary phase inducible protein CsiE 2888788..2890068 Escherichia coli 55989 7148767 YP_002403830.1 CDS hcaT NC_011748.1 2890060 2891199 R transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters; 3-phenylpropionic acid transporter complement(2890060..2891199) Escherichia coli 55989 7145775 YP_002403831.1 CDS hcaR NC_011748.1 2891359 2892249 R activator of 3-phenylpropionic acid catabolism; DNA-binding transcriptional regulator HcaR complement(2891359..2892249) Escherichia coli 55989 7146396 YP_002403832.1 CDS hcaE NC_011748.1 2892385 2893746 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83238171, 87008429, 98269008; Product type e : enzyme; 3-phenylpropionate dioxygenase, large (alpha) subunit 2892385..2893746 Escherichia coli 55989 7146395 YP_002403833.1 CDS hcaF NC_011748.1 2893743 2894261 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83238171, 87008429, 98269008, 9603882; Product type e : enzyme; 3-phenylpropionate dioxygenase subunit beta 2893743..2894261 Escherichia coli 55989 7146393 YP_002403834.1 CDS hcaC NC_011748.1 2894261 2894581 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98269008, 9603882; Product type pc : carrier; 3-phenylpropionate dioxygenase ferredoxin subunit 2894261..2894581 Escherichia coli 55989 7146394 YP_002403835.1 CDS hcaB NC_011748.1 2894578 2895390 D Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate; 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase 2894578..2895390 Escherichia coli 55989 7146391 YP_002403836.1 CDS hcaD NC_011748.1 2895400 2896602 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98269008, 9603882; Product type e : enzyme; phenylpropionate dioxygenase ferredoxin reductase subunit 2895400..2896602 Escherichia coli 55989 7146390 YP_002403837.1 CDS yphA NC_011748.1 2896699 2897121 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2896699..2897121 Escherichia coli 55989 7146392 YP_002403838.1 CDS yphB NC_011748.1 2897169 2898041 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2897169..2898041) Escherichia coli 55989 7149380 YP_002403839.1 CDS yphC NC_011748.1 2898053 2899114 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase, Zn-dependent and NAD(P)-binding complement(2898053..2899114) Escherichia coli 55989 7149381 YP_002403840.1 CDS yphD NC_011748.1 2899180 2900178 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sugar transporter subunit: membrane component of ABC superfamily complement(2899180..2900178) Escherichia coli 55989 7149382 YP_002403841.1 CDS yphE NC_011748.1 2900203 2901714 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; fused sugar transporter subunits of ABC superfamily: ATP-binding components complement(2900203..2901714) Escherichia coli 55989 7149383 YP_002403842.1 CDS yphF NC_011748.1 2901737 2902720 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : transporter; sugar transporter subunit: periplasmic-binding component of ABC superfamily complement(2901737..2902720) Escherichia coli 55989 7149384 YP_002403843.1 CDS yphG NC_011748.1 2902817 2906098 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2902817..2906098) Escherichia coli 55989 7149385 YP_002403844.1 CDS yphH NC_011748.1 2906216 2907409 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 2906216..2907409 Escherichia coli 55989 7149386 YP_002403845.1 CDS glyA NC_011748.1 2907473 2908726 R catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate; serine hydroxymethyltransferase complement(2907473..2908726) Escherichia coli 55989 7149387 YP_002403846.1 CDS hmp NC_011748.1 2909054 2910244 D flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine; nitric oxide dioxygenase 2909054..2910244 Escherichia coli 55989 7146339 YP_002403847.1 CDS glnB NC_011748.1 2910289 2910627 R indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; nitrogen regulatory protein P-II 1 complement(2910289..2910627) Escherichia coli 55989 7146447 YP_002403848.1 CDS yfhA NC_011748.1 2910688 2912022 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8226691, 8412694; Product type pr : regulator; two component system DNA-binding response regulator complement(2910688..2912022) Escherichia coli 55989 7146303 YP_002403849.1 CDS yfhG NC_011748.1 2912012 2912725 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2912012..2912725) Escherichia coli 55989 7148757 YP_002403850.1 CDS yfhK NC_011748.1 2912890 2914317 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; sensory kinase in two-component system complement(2912890..2914317) Escherichia coli 55989 7148760 YP_002403851.1 CDS purL NC_011748.1 2914893 2918780 R catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis; phosphoribosylformylglycinamidine synthase complement(2914893..2918780) Escherichia coli 55989 7147803 YP_002403852.1 CDS yfhD NC_011748.1 2919176 2920594 D YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function; transglycosylase 2919176..2920594 Escherichia coli 55989 7147300 YP_002403853.1 CDS tadA NC_011748.1 2920591 2921127 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12110595; Product type e : enzyme; tRNA-specific adenosine deaminase complement(2920591..2921127) Escherichia coli 55989 7148759 YP_002403854.1 CDS yfhB NC_011748.1 2921152 2921787 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2921152..2921787) Escherichia coli 55989 7147745 YP_002403855.1 CDS yfhH NC_011748.1 2921996 2922844 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 2921996..2922844 Escherichia coli 55989 7148758 YP_002403856.1 CDS yfhL NC_011748.1 2922900 2923160 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8765743, 8880900; Product type c : carrier; ferredoxin (4Fe-4S cluster-containing protein) (fdx-like) 2922900..2923160 Escherichia coli 55989 7148761 YP_002403857.1 CDS EC55989_2850 NC_011748.1 2923431 2923595 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2923431..2923595) Escherichia coli 55989 7147582 YP_002403858.1 CDS acpS NC_011748.1 2923854 2924234 R Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids; 4'-phosphopantetheinyl transferase complement(2923854..2924234) Escherichia coli 55989 7147583 YP_002403859.1 CDS pdxJ NC_011748.1 2924234 2924965 R involved in the de novo synthesis of pyridoxine (Vitamin B6); pyridoxine 5'-phosphate synthase complement(2924234..2924965) Escherichia coli 55989 7145442 YP_002403860.1 CDS recO NC_011748.1 2924977 2925705 R involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA; DNA repair protein RecO complement(2924977..2925705) Escherichia coli 55989 7147127 YP_002403861.1 CDS era NC_011748.1 2925717 2926622 R Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome; GTP-binding protein Era complement(2925717..2926622) Escherichia coli 55989 7147365 YP_002403862.1 CDS rnc NC_011748.1 2926619 2927299 R cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity; ribonuclease III complement(2926619..2927299) Escherichia coli 55989 7146020 YP_002403863.1 CDS lepB NC_011748.1 2927572 2928546 R catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins; signal peptidase I complement(2927572..2928546) Escherichia coli 55989 7147445 YP_002403864.1 CDS lepA NC_011748.1 2928562 2930361 R binds to the ribosome on the universally-conserved alpha-sarcin loop; GTP-binding protein LepA complement(2928562..2930361) Escherichia coli 55989 7146688 YP_002403865.1 CDS rseC NC_011748.1 2930559 2931038 R involved in the reduction of the SoxR iron-sulfur cluster; SoxR reducing system protein RseC complement(2930559..2931038) Escherichia coli 55989 7146687 YP_002403866.1 CDS rseB NC_011748.1 2931035 2931991 R periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP; periplasmic negative regulator of sigmaE complement(2931035..2931991) Escherichia coli 55989 7147532 YP_002403867.1 CDS rseA NC_011748.1 2931991 2932641 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9159522, 97303092, 99431977, 7768826; Product type f : factor; anti-RNA polymerase sigma factor SigE complement(2931991..2932641) Escherichia coli 55989 7147531 YP_002403868.1 CDS rpoE NC_011748.1 2932674 2933249 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response; RNA polymerase sigma factor RpoE complement(2932674..2933249) Escherichia coli 55989 7147530 YP_002403869.1 CDS nadB NC_011748.1 2933657 2935279 D catalyzes the formation of oxaloacetate from L-aspartate; L-aspartate oxidase 2933657..2935279 Escherichia coli 55989 7147499 YP_002403870.1 CDS yfiC NC_011748.1 2935264 2936001 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; S-adenosyl-L-methionine-dependent methyltransferase complement(2935264..2936001) Escherichia coli 55989 7146943 YP_002403871.1 CDS srmB NC_011748.1 2936133 2937467 D facilitates an early step in the assembly of the 50S subunit of the ribosome; ATP-dependent RNA helicase SrmB 2936133..2937467 Escherichia coli 55989 7148770 YP_002403872.1 CDS yfiE NC_011748.1 2937676 2938557 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(2937676..2938557) Escherichia coli 55989 7147707 YP_002403873.1 CDS yfiK NC_011748.1 2938660 2939247 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12562784; Product type t : transporter; neutral amino-acid efflux protein 2938660..2939247 Escherichia coli 55989 7148772 YP_002403874.1 CDS yfiD NC_011748.1 2939302 2939685 R stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit; autonomous glycyl radical cofactor GrcA complement(2939302..2939685) Escherichia coli 55989 7148775 YP_002403875.1 CDS ung NC_011748.1 2939990 2940679 D Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine; uracil-DNA glycosylase 2939990..2940679 Escherichia coli 55989 7148771 YP_002403876.1 CDS yfiF NC_011748.1 2940727 2941764 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; methyltransferase complement(2940727..2941764) Escherichia coli 55989 7147923 YP_002403877.1 CDS EC55989_2871 NC_011748.1 2941754 2941957 R Evidence 4 : Homologs of previously reported genes of unknown function; Z3866 protein complement(2941754..2941957) Escherichia coli 55989 7148773 YP_002403878.1 CDS trxC NC_011748.1 2941971 2942390 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12952960, 9388228, 99175138, 10644706; Product type c : carrier; thioredoxin 2 2941971..2942390 Escherichia coli 55989 7144831 YP_002403879.1 CDS yfiP NC_011748.1 2942459 2943157 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2942459..2943157 Escherichia coli 55989 7147864 YP_002403880.1 CDS yfiQ NC_011748.1 2943189 2945849 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; fused acyl-CoA synthetase: NAD(P)-binding subunit ; ATP-binding subunit 2943189..2945849 Escherichia coli 55989 7148780 YP_002403881.1 CDS pssA NC_011748.1 2945963 2947318 D catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome; phosphatidylserine synthase 2945963..2947318 Escherichia coli 55989 7148781 YP_002403882.1 CDS yfiM NC_011748.1 2947415 2947687 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2947415..2947687 Escherichia coli 55989 7147276 YP_002403883.1 CDS kgtP NC_011748.1 2947684 2948982 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91219460, 1709493, 2053984, 2118499, 2190187, 8419306; Product type t : transporter; alpha-ketoglutarate transporter complement(2947684..2948982) Escherichia coli 55989 7148777 YP_002403884.1 CDS clpB NC_011748.1 2954848 2957421 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14550559, 14640692, 91294166, 93015925, 93388583, 99428468; Product type f : factor; protein disaggregation chaperone complement(2954848..2957421) Escherichia coli 55989 7144633 YP_002403885.1 CDS yfiH NC_011748.1 2957551 2958282 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1906060, 2066329; hypothetical protein complement(2957551..2958282) Escherichia coli 55989 7147584 YP_002403886.1 CDS rluD NC_011748.1 2958279 2959259 R responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA; 23S rRNA pseudouridine synthase D complement(2958279..2959259) Escherichia coli 55989 7148774 YP_002403887.1 CDS yfiO NC_011748.1 2959394 2960131 D with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline; outer membrane protein assembly complex subunit YfiO 2959394..2960131 Escherichia coli 55989 7147429 YP_002403888.1 CDS yfiA NC_011748.1 2960402 2960743 D associated with 30S ribosomal subunit; interferes with translation elongation; translation inhibitor protein RaiA 2960402..2960743 Escherichia coli 55989 7148779 YP_002403890.1 CDS pheA NC_011748.1 2960993 2962153 D catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis; bifunctional chorismate mutase/prephenate dehydratase 2960993..2962153 Escherichia coli 55989 7147158 YP_002403891.1 CDS tyrA NC_011748.1 2962196 2963317 R catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis; bifunctional chorismate mutase/prephenate dehydrogenase complement(2962196..2963317) Escherichia coli 55989 7147157 YP_002403892.1 CDS aroF NC_011748.1 2963328 2964398 R catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive; phospho-2-dehydro-3-deoxyheptonate aldolase complement(2963328..2964398) Escherichia coli 55989 7147881 YP_002403893.1 CDS yfiL NC_011748.1 2964608 2964973 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6396419; hypothetical protein 2964608..2964973 Escherichia coli 55989 7145544 YP_002403894.1 CDS yfiR NC_011748.1 2965123 2965641 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2965123..2965641 Escherichia coli 55989 7148776 YP_002403895.1 CDS yfiN NC_011748.1 2965631 2966857 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; hypothetical protein 2965631..2966857 Escherichia coli 55989 7148782 YP_002403896.1 CDS yfiB NC_011748.1 2966873 2967355 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 96032391; Product type pm : membrane component; outer membrane lipoprotein 2966873..2967355 Escherichia coli 55989 7148778 YP_002403897.1 CDS rplS NC_011748.1 2967432 2967779 R this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site; 50S ribosomal protein L19 complement(2967432..2967779) Escherichia coli 55989 7148769 YP_002403898.1 CDS trmD NC_011748.1 2967821 2968588 R methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA; tRNA (guanine-N(1)-)-methyltransferase complement(2967821..2968588) Escherichia coli 55989 7147479 YP_002403899.1 CDS rimM NC_011748.1 2968619 2969167 R Essential for efficient processing of 16S rRNA; 16S rRNA-processing protein RimM complement(2968619..2969167) Escherichia coli 55989 7147846 YP_002403900.1 CDS rpsP NC_011748.1 2969186 2969434 R binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity; 30S ribosomal protein S16 complement(2969186..2969434) Escherichia coli 55989 7147422 YP_002403901.1 CDS ffh NC_011748.1 2969571 2970932 R with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins; signal recognition particle protein complement(2969571..2970932) Escherichia coli 55989 7147520 YP_002403902.1 CDS ypjD NC_011748.1 2971024 2971890 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 2971024..2971890 Escherichia coli 55989 7146095 YP_002403903.1 CDS yfjD NC_011748.1 2972001 2973197 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 2972001..2973197 Escherichia coli 55989 7149388 YP_002403904.1 CDS grpE NC_011748.1 2973252 2973845 R with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor; heat shock protein GrpE complement(2973252..2973845) Escherichia coli 55989 7148784 YP_002403905.1 CDS ppnK NC_011748.1 2973968 2974846 D catalyzes the phosphorylation of NAD to NADP; inorganic polyphosphate/ATP-NAD kinase 2973968..2974846 Escherichia coli 55989 7146369 YP_002403906.1 CDS recN NC_011748.1 2974932 2976593 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87259985, 91355307, 95058623, 3037486; Product type cp : cell process; recombination and repair protein 2974932..2976593 Escherichia coli 55989 7148783 YP_002403907.1 CDS smpA NC_011748.1 2976742 2977083 D Evidence 2b : Function of strongly homologous gene; PubMedId : 2045357; Product type lp : lipoprotein; hypothetical protein 2976742..2977083 Escherichia coli 55989 7147364 YP_002403908.1 CDS yfjF NC_011748.1 2977145 2977435 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2977145..2977435) Escherichia coli 55989 7147668 YP_002403909.1 CDS yfjG NC_011748.1 2977425 2977901 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(2977425..2977901) Escherichia coli 55989 7148785 YP_002403910.1 CDS smpB NC_011748.1 2978033 2978515 D binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation; SsrA-binding protein 2978033..2978515 Escherichia coli 55989 7148786 YP_002403911.1 CDS intA NC_011748.1 2979298 2980539 D CP4-57 prophage; integrase; integrase 2979298..2980539 Escherichia coli 55989 7147716 YP_002403912.1 CDS EC55989_2910 NC_011748.1 2980678 2984424 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein complement(2980678..2984424) Escherichia coli 55989 7146607 YP_002403913.1 CDS EC55989_2911 NC_011748.1 2984892 2988743 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; hypothetical protein 2984892..2988743 Escherichia coli 55989 7144832 YP_002403914.1 CDS EC55989_2912 NC_011748.1 2988789 2989535 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2988789..2989535 Escherichia coli 55989 7144833 YP_002403915.1 CDS EC55989_2913 NC_011748.1 2989387 2989701 D Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein 2989387..2989701 Escherichia coli 55989 7144834 YP_002403916.1 CDS EC55989_2914 NC_011748.1 2989786 2989944 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2989786..2989944) Escherichia coli 55989 7144835 YP_002403917.1 CDS EC55989_2915 NC_011748.1 2989969 2990850 R Evidence 5 : No homology to any previously reported sequences; Product type h : extrachromosomal origin; hypothetical protein complement(2989969..2990850) Escherichia coli 55989 7144836 YP_002403918.1 CDS EC55989_2916 NC_011748.1 2991369 2991668 D Evidence 7 : Gene remnant; Product type h : extrachromosomal origin; GTP-binding factor (fragment) from CP4-like prophage 2991369..2991668 Escherichia coli 55989 7144837 YP_002403919.1 CDS EC55989_2917 NC_011748.1 2991689 2992036 D Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase ORF A, IS3 family 2991689..2992036 Escherichia coli 55989 7144838 YP_002403920.1 CDS EC55989_2919 NC_011748.1 2992872 2993471 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; outer membrane protein complement(2992872..2993471) Escherichia coli 55989 7144840 YP_002403921.1 CDS EC55989_2923 NC_011748.1 2996141 2996470 R Evidence 6 : Doubtful CDS; hypothetical protein complement(2996141..2996470) Escherichia coli 55989 7144843 YP_002403922.1 CDS yqaD NC_011748.1 2998993 2999265 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 2998993..2999265 Escherichia coli 55989 7144846 YP_002403923.1 CDS ygaT NC_011748.1 2999601 3000578 D in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution; hypothetical protein 2999601..3000578 Escherichia coli 55989 7149391 YP_002403924.1 CDS ygaF NC_011748.1 3000598 3001866 D catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate; hydroxyglutarate oxidase 3000598..3001866 Escherichia coli 55989 7148794 YP_002403925.1 CDS gabD NC_011748.1 3001889 3003337 D catalyzes the formation of succinate from succinate semialdehyde; NADP dependent; succinate-semialdehyde dehydrogenase I 3001889..3003337 Escherichia coli 55989 7148790 YP_002403926.1 CDS gabT NC_011748.1 3003351 3004631 D catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate; 4-aminobutyrate aminotransferase 3003351..3004631 Escherichia coli 55989 7146237 YP_002403927.1 CDS gabP NC_011748.1 3004942 3006342 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94127927, 9685361, 8297211; Product type t : transporter; gamma-aminobutyrate transporter 3004942..3006342 Escherichia coli 55989 7146239 YP_002403928.1 CDS csiR NC_011748.1 3006363 3007025 D regulator of gab gene expression; DNA-binding transcriptional regulator CsiR 3006363..3007025 Escherichia coli 55989 7146238 YP_002403929.1 CDS ygaU NC_011748.1 3007026 3007475 R Evidence 4 : Homologs of previously reported genes of unknown function; LysM domain/BON superfamily protein complement(3007026..3007475) Escherichia coli 55989 7145776 YP_002403930.1 CDS yqaE NC_011748.1 3007559 3007717 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(3007559..3007717) Escherichia coli 55989 7148795 YP_002403931.1 CDS ygaV NC_011748.1 3007900 3008199 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 3007900..3008199 Escherichia coli 55989 7149392 YP_002403932.1 CDS ygaP NC_011748.1 3008209 3008733 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pe : enzyme; inner membrane protein with hydrolase activity 3008209..3008733 Escherichia coli 55989 7148796 YP_002403933.1 CDS stpA NC_011748.1 3008780 3009184 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20485613, 93126121, 9643551, 98132400, 99415935, 1480493, 7961433; Product type r : regulator; DNA binding protein complement(3008780..3009184) Escherichia coli 55989 7148793 YP_002403934.1 CDS ygaW NC_011748.1 3009852 3010301 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3009852..3010301 Escherichia coli 55989 7147725 YP_002403935.1 CDS ygaC NC_011748.1 3010338 3010682 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7961433; hypothetical protein complement(3010338..3010682) Escherichia coli 55989 7148797 YP_002403936.1 CDS ygaM NC_011748.1 3010822 3011163 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3010822..3011163 Escherichia coli 55989 7148788 YP_002403937.1 CDS nrdH NC_011748.1 3011411 3011656 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9218434, 11441020, 8820648; Product type pc : carrier; glutaredoxin-like protein 3011411..3011656 Escherichia coli 55989 7148792 YP_002403938.1 CDS nrdI NC_011748.1 3011653 3012063 D in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF; ribonucleotide reductase stimulatory protein 3011653..3012063 Escherichia coli 55989 7147024 YP_002403939.1 CDS nrdE NC_011748.1 3012036 3014180 D Catalyzes the rate-limiting step in dNTP synthesis; ribonucleotide-diphosphate reductase subunit alpha 3012036..3014180 Escherichia coli 55989 7147025 YP_002403940.1 CDS nrdF NC_011748.1 3014190 3015149 D B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE; ribonucleotide-diphosphate reductase subunit beta 3014190..3015149 Escherichia coli 55989 7147021 YP_002403941.1 CDS proV NC_011748.1 3015504 3016706 D with ProWX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter ATP-binding subunit 3015504..3016706 Escherichia coli 55989 7147022 YP_002403942.1 CDS proW NC_011748.1 3016699 3017763 D with ProVX is involved in the high-affinity uptake of glycine betaine; glycine betaine transporter membrane protein 3016699..3017763 Escherichia coli 55989 7147258 YP_002403943.1 CDS proX NC_011748.1 3017820 3018812 D with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine; glycine betaine transporter periplasmic subunit 3017820..3018812 Escherichia coli 55989 7147259 YP_002403944.1 CDS EC55989_2948 NC_011748.1 3019004 3020188 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16000740; Product type pt : transporter; transport protein (ousB-like) 3019004..3020188 Escherichia coli 55989 7147260 YP_002403945.1 CDS ygaZ NC_011748.1 3020312 3021049 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 3020312..3021049 Escherichia coli 55989 7144847 YP_002403946.1 CDS ygaH NC_011748.1 3021039 3021374 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 3021039..3021374 Escherichia coli 55989 7148798 YP_002403947.1 CDS mprA NC_011748.1 3021465 3021995 D DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB; transcriptional repressor MprA 3021465..3021995 Escherichia coli 55989 7148791 YP_002403948.1 CDS emrA NC_011748.1 3022122 3023294 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590, 8203018; Product type t : transporter; multidrug efflux system 3022122..3023294 Escherichia coli 55989 7146893 YP_002403949.1 CDS emrB NC_011748.1 3023311 3024849 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803, 93285984, 94262163, 1409590; Product type t : transporter; multidrug efflux system protein 3023311..3024849 Escherichia coli 55989 7145989 YP_002403950.1 CDS luxS NC_011748.1 3024913 3025428 R catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2; S-ribosylhomocysteinase complement(3024913..3025428) Escherichia coli 55989 7145990 YP_002403951.1 CDS gshA NC_011748.1 3025578 3027134 R involved in the first step of glutathione biosynthesis; glutamate--cysteine ligase complement(3025578..3027134) Escherichia coli 55989 7146854 YP_002403952.1 CDS yqaA NC_011748.1 3027207 3027635 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(3027207..3027635) Escherichia coli 55989 7146373 YP_002403953.1 CDS yqaB NC_011748.1 3027632 3028198 R YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent; fructose-1-phosphatase complement(3027632..3028198) Escherichia coli 55989 7149389 YP_002403954.1 CDS csrA NC_011748.1 3029791 3029976 R affects carbohydrate metabolism; has regulatory role in many processes; carbon storage regulator complement(3029791..3029976) Escherichia coli 55989 7145380 YP_002403955.1 CDS alaS NC_011748.1 3030211 3032841 R Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; alanyl-tRNA synthetase complement(3030211..3032841) Escherichia coli 55989 7145783 YP_002403956.1 CDS recX NC_011748.1 3032969 3033469 R binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities; recombination regulator RecX complement(3032969..3033469) Escherichia coli 55989 7145478 YP_002403957.1 CDS recA NC_011748.1 3033712 3034773 R catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs; recombinase A complement(3033712..3034773) Escherichia coli 55989 7147368 YP_002403958.1 CDS ygaD NC_011748.1 3034853 3035350 R Evidence 4 : Homologs of previously reported genes of unknown function; competence damage-inducible protein A complement(3034853..3035350) Escherichia coli 55989 7147357 YP_002403959.1 CDS mltB NC_011748.1 3035495 3036580 R membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan; murein hydrolase B complement(3035495..3036580) Escherichia coli 55989 7148789 YP_002403960.1 CDS srlA NC_011748.1 3036836 3037399 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87194727, 1334233, 3553176; Product type t : transporter; PTS system glucitol/sorbitol-specific transporter subunit IIC 3036836..3037399 Escherichia coli 55989 7146864 YP_002403961.1 CDS srlE NC_011748.1 3037396 3038355 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1100602, 3553176; Product type t : transporter; glucitol/sorbitol-specific enzyme IIB component of PTS 3037396..3038355 Escherichia coli 55989 7147702 YP_002403962.1 CDS srlB NC_011748.1 3038366 3038737 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system glucitol/sorbitol-specific transporter subunit IIA 3038366..3038737 Escherichia coli 55989 7147705 YP_002403963.1 CDS srlD NC_011748.1 3038741 3039520 D catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate; sorbitol-6-phosphate dehydrogenase 3038741..3039520 Escherichia coli 55989 7147703 YP_002403964.1 CDS gutM NC_011748.1 3039625 3039984 D regulator for glucitol utilization; DNA-binding transcriptional activator GutM 3039625..3039984 Escherichia coli 55989 7147704 YP_002403965.1 CDS srlR NC_011748.1 3040051 3040824 D regulates genes involved in glucitol utilization; DNA-binding transcriptional repressor SrlR 3040051..3040824 Escherichia coli 55989 7146386 YP_002403966.1 CDS gutQ NC_011748.1 3040817 3041782 D catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate; D-arabinose 5-phosphate isomerase 3040817..3041782 Escherichia coli 55989 7147706 YP_002403967.1 CDS norR NC_011748.1 3041779 3043293 R Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon; anaerobic nitric oxide reductase transcriptional regulator complement(3041779..3043293) Escherichia coli 55989 7146387 YP_002403968.1 CDS norV NC_011748.1 3043480 3044919 D detoxifies nitric oxide using NADH; anaerobic nitric oxide reductase flavorubredoxin 3043480..3044919 Escherichia coli 55989 7147014 YP_002403969.1 CDS norW NC_011748.1 3044916 3046049 D catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase; nitric oxide reductase 3044916..3046049 Escherichia coli 55989 7147015 YP_002403970.1 CDS hypF NC_011748.1 3046275 3048527 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12377778, 92255260, 8661925; Product type e : enzyme; carbamoyl phosphate phosphatase and maturation protein for [NiFe] hydrogenases complement(3046275..3048527) Escherichia coli 55989 7145652 YP_002403971.1 CDS hydN NC_011748.1 3048680 3049207 R involved in electron transport from formate to hydrogen; electron transport protein HydN complement(3048680..3049207) Escherichia coli 55989 7146525 YP_002403972.1 CDS ascG NC_011748.1 3049356 3050369 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88297127, 92334140, 1630307; Product type r : regulator; DNA-binding transcriptional repressor complement(3049356..3050369) Escherichia coli 55989 7146505 YP_002403973.1 CDS ascF NC_011748.1 3050626 3052083 D phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system cellobiose/arbutin/salicin-specific transporter subunit IIBC 3050626..3052083 Escherichia coli 55989 7145562 YP_002403974.1 CDS ascB NC_011748.1 3052092 3053516 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88297127, 92334140, 1630307; Product type e : enzyme; cryptic 6-phospho-beta-glucosidase 3052092..3053516 Escherichia coli 55989 7145561 YP_002403975.1 CDS EC55989_2979 NC_011748.1 3053684 3054664 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family complement(3053684..3054664) Escherichia coli 55989 7145560 YP_002403976.1 CDS EC55989_2981 NC_011748.1 3054909 3055394 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; HTH-type transcriptional regulator ygjM complement(3054909..3055394) Escherichia coli 55989 7144848 YP_002403977.1 CDS EC55989_2982 NC_011748.1 3055399 3056172 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3055399..3056172) Escherichia coli 55989 7144849 YP_002403978.1 CDS hycI NC_011748.1 3056197 3056667 R involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE; hydrogenase 3 maturation protease complement(3056197..3056667) Escherichia coli 55989 7144850 YP_002403979.1 CDS hycH NC_011748.1 3056660 3057070 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 1625581, 2187144, 7851435; Product type f : factor; protein required for maturation of hydrogenase 3 complement(3056660..3057070) Escherichia coli 55989 7146504 YP_002403980.1 CDS hycG NC_011748.1 3057067 3057834 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type e : enzyme; hydrogenase 3 and formate hydrogenase complex, HycG subunit complement(3057067..3057834) Escherichia coli 55989 7146503 YP_002403981.1 CDS hycF NC_011748.1 3057834 3058376 R electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate; formate hydrogenlyase complex iron-sulfur subunit complement(3057834..3058376) Escherichia coli 55989 7146502 YP_002403982.1 CDS hycE NC_011748.1 3058386 3060095 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 92326636, 94170785, 2187144, 8125094; Product type e : enzyme; hydrogenase 3, large subunit complement(3058386..3060095) Escherichia coli 55989 7146501 YP_002403983.1 CDS hycD NC_011748.1 3060113 3061036 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636; Product type m : membrane component; hydrogenase 3, membrane subunit complement(3060113..3061036) Escherichia coli 55989 7146500 YP_002403984.1 CDS hycC NC_011748.1 3061039 3062865 R catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3); formate hydrogenlyase subunit 3 complement(3061039..3062865) Escherichia coli 55989 7146499 YP_002403985.1 CDS hycB NC_011748.1 3062862 3063473 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90251163, 92215587, 92326636, 2187144; Product type c : carrier; hydrogenase 3, Fe-S subunit complement(3062862..3063473) Escherichia coli 55989 7146498 YP_002403986.1 CDS hycA NC_011748.1 3063598 3064059 R regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon; formate hydrogenlyase regulatory protein HycA complement(3063598..3064059) Escherichia coli 55989 7146497 YP_002403987.1 CDS hypA NC_011748.1 3064270 3064620 D plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein 3064270..3064620 Escherichia coli 55989 7146496 YP_002403988.1 CDS hypB NC_011748.1 3064624 3065496 D GTP hydrolase involved in nickel liganding into hydrogenases; hydrogenase nickel incorporation protein HypB 3064624..3065496 Escherichia coli 55989 7146520 YP_002403989.1 CDS hypC NC_011748.1 3065487 3065759 D HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase; hydrogenase assembly chaperone 3065487..3065759 Escherichia coli 55989 7146521 YP_002403990.1 CDS hypD NC_011748.1 3065759 3066880 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 92255260, 1849603; Product type f : factor; hydrogenase maturation protein 3065759..3066880 Escherichia coli 55989 7146522 YP_002403991.1 CDS hypE NC_011748.1 3066919 3067887 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91194542, 9485446, 1849603; Product type e : enzyme; carbamoyl phosphate phosphatase, hydrogenase 3 maturation protein 3066919..3067887 Escherichia coli 55989 7146523 YP_002403992.1 CDS fhlA NC_011748.1 3067961 3070039 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20307603, 21557168, 90368529, 92140045, 94018617, 2118503, 2280686; Product type r : regulator; DNA-binding transcriptional activator 3067961..3070039 Escherichia coli 55989 7146524 YP_002403993.1 CDS ygbA NC_011748.1 3070076 3070429 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3070076..3070429) Escherichia coli 55989 7146098 YP_002403994.1 CDS mutS NC_011748.1 3070716 3073277 D This protein performs the mismatch recognition step during the DNA repair process; DNA mismatch repair protein MutS 3070716..3073277 Escherichia coli 55989 7148799 YP_002403995.1 CDS pphB NC_011748.1 3073383 3074039 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9130712; Product type e : enzyme; serine/threonine-specific protein phosphatase 2 3073383..3074039 Escherichia coli 55989 7146934 YP_002403996.1 CDS ygbI NC_011748.1 3074090 3074887 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(3074090..3074887) Escherichia coli 55989 7147227 YP_002403997.1 CDS ygbJ NC_011748.1 3075053 3075961 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; dehydrogenase, with NAD(P)-binding Rossmann-fold domain 3075053..3075961 Escherichia coli 55989 7148802 YP_002403998.1 CDS ygbK NC_011748.1 3075958 3077220 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11520622; hypothetical protein 3075958..3077220 Escherichia coli 55989 7148803 YP_002403999.1 CDS ygbL NC_011748.1 3077217 3077855 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; aldolase 3077217..3077855 Escherichia coli 55989 7148804 YP_002404000.1 CDS ygbM NC_011748.1 3077860 3078636 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3077860..3078636 Escherichia coli 55989 7148805 YP_002404001.1 CDS ygbN NC_011748.1 3078725 3080089 D member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function; inner membrane permease YgbN 3078725..3080089 Escherichia coli 55989 7148806 YP_002404002.1 CDS EC55989_3008 NC_011748.1 3080129 3080365 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; conserved non-oxidative reversible hydroxyarylic acid decarboxylase complement(3080129..3080365) Escherichia coli 55989 7148807 YP_002404003.1 CDS EC55989_3009 NC_011748.1 3080376 3081803 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; conserved non-oxidative hydroxyarylic acid decarboxylase activity complement(3080376..3081803) Escherichia coli 55989 7144851 YP_002404004.1 CDS EC55989_3010 NC_011748.1 3081803 3082396 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15979273; Product type e : enzyme; conserved non-oxidative reversible hydroxyarylic acid decarboxylase complement(3081803..3082396) Escherichia coli 55989 7144852 YP_002404005.1 CDS EC55989_3011 NC_011748.1 3082543 3082950 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15731069; Product type r : regulator; Transcriptional regulator hosA 3082543..3082950 Escherichia coli 55989 7144853 YP_002404006.1 CDS rpoS NC_011748.1 3083071 3084063 R sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses; RNA polymerase sigma factor RpoS complement(3083071..3084063) Escherichia coli 55989 7144854 YP_002404007.1 CDS nlpD NC_011748.1 3084126 3085265 R outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus; lipoprotein NlpD complement(3084126..3085265) Escherichia coli 55989 7147502 YP_002404008.1 CDS pcm NC_011748.1 3085405 3086031 R catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins; protein-L-isoaspartate O-methyltransferase complement(3085405..3086031) Escherichia coli 55989 7147009 YP_002404009.1 CDS surE NC_011748.1 3086025 3086786 R catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate; stationary phase survival protein SurE complement(3086025..3086786) Escherichia coli 55989 7147121 YP_002404010.1 CDS truD NC_011748.1 3086767 3087816 R catalyzes the modification of U13 in tRNA(Glu); tRNA pseudouridine synthase D complement(3086767..3087816) Escherichia coli 55989 7147741 YP_002404011.1 CDS ispF NC_011748.1 3087813 3088292 R catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase complement(3087813..3088292) Escherichia coli 55989 7147861 YP_002404012.1 CDS ispD NC_011748.1 3088292 3089002 R 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase complement(3088292..3089002) Escherichia coli 55989 7146629 YP_002404013.1 CDS ftsB NC_011748.1 3089021 3089332 R forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein; cell division protein FtsB complement(3089021..3089332) Escherichia coli 55989 7146627 YP_002404014.1 CDS ygbE NC_011748.1 3089526 3089849 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(3089526..3089849) Escherichia coli 55989 7146211 YP_002404015.1 CDS cysC NC_011748.1 3089899 3090504 R converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis; adenylylsulfate kinase complement(3089899..3090504) Escherichia coli 55989 7148800 YP_002404016.1 CDS cysN NC_011748.1 3090504 3091931 R may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ; sulfate adenylyltransferase subunit 1 complement(3090504..3091931) Escherichia coli 55989 7145822 YP_002404017.1 CDS cysD NC_011748.1 3091933 3092841 R with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP; sulfate adenylyltransferase subunit 2 complement(3091933..3092841) Escherichia coli 55989 7145831 YP_002404018.1 CDS iap NC_011748.1 3093093 3094130 D catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3; alkaline phosphatase 3093093..3094130 Escherichia coli 55989 7145823 YP_002404019.1 CDS ygbF NC_011748.1 3094398 3094691 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3094398..3094691) Escherichia coli 55989 7146530 YP_002404020.1 CDS ygbT NC_011748.1 3094691 3095611 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3094691..3095611) Escherichia coli 55989 7148801 YP_002404021.1 CDS EC55989_3029 NC_011748.1 3095608 3096396 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3095608..3096396) Escherichia coli 55989 7148808 YP_002404022.1 CDS EC55989_3030 NC_011748.1 3096240 3096986 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3096240..3096986) Escherichia coli 55989 7144855 YP_002404023.1 CDS EC55989_3031 NC_011748.1 3096997 3098052 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3096997..3098052) Escherichia coli 55989 7144856 YP_002404024.1 CDS EC55989_3032 NC_011748.1 3098064 3098600 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3098064..3098600) Escherichia coli 55989 7144857 YP_002404025.1 CDS EC55989_3033 NC_011748.1 3098597 3100228 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3098597..3100228) Escherichia coli 55989 7144858 YP_002404026.1 CDS EC55989_3034 NC_011748.1 3100257 3102956 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3100257..3102956) Escherichia coli 55989 7144859 YP_002404027.1 CDS EC55989_3035 NC_011748.1 3103150 3103302 R Evidence 1b : Function experimentally demonstrated in the studied species; Product type pm : membrane component; small toxic peptide complement(3103150..3103302) Escherichia coli 55989 7144860 YP_002404028.1 CDS cysH NC_011748.1 3103567 3104301 R catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite; phosphoadenosine phosphosulfate reductase complement(3103567..3104301) Escherichia coli 55989 7144861 YP_002404029.1 CDS cysI NC_011748.1 3104375 3106087 R hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide; sulfite reductase subunit beta complement(3104375..3106087) Escherichia coli 55989 7145826 YP_002404030.1 CDS cysJ NC_011748.1 3106087 3107886 R catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity; sulfite reductase subunit alpha complement(3106087..3107886) Escherichia coli 55989 7145827 YP_002404031.1 CDS ygcM NC_011748.1 3108202 3108567 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123838; Product type e : enzyme; 6-pyruvoyl tetrahydrobiopterin synthase 3108202..3108567 Escherichia coli 55989 7145828 YP_002404032.1 CDS ygcN NC_011748.1 3108645 3109916 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase with FAD/NAD(P)-binding domain 3108645..3109916 Escherichia coli 55989 7148812 YP_002404033.1 CDS ygcO NC_011748.1 3109907 3110167 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; 4Fe-4S binding protein 3109907..3110167 Escherichia coli 55989 7148813 YP_002404034.1 CDS ygcP NC_011748.1 3110184 3110759 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; anti-terminator regulatory protein 3110184..3110759 Escherichia coli 55989 7148814 YP_002404035.1 CDS ygcQ NC_011748.1 3110907 3111767 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; flavoprotein complement(3110907..3111767) Escherichia coli 55989 7148815 YP_002404036.1 CDS ygcR NC_011748.1 3111764 3112543 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; flavoprotein complement(3111764..3112543) Escherichia coli 55989 7148816 YP_002404037.1 CDS ygcS NC_011748.1 3112521 3113858 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter complement(3112521..3113858) Escherichia coli 55989 7148817 YP_002404038.1 CDS ygcU NC_011748.1 3113952 3115406 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; FAD containing dehydrogenase complement(3113952..3115406) Escherichia coli 55989 7148818 YP_002404039.1 CDS ygcW NC_011748.1 3115476 3116261 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; deoxygluconate dehydrogenase complement(3115476..3116261) Escherichia coli 55989 7148819 YP_002404040.1 CDS yqcE NC_011748.1 3116580 3117857 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 3116580..3117857 Escherichia coli 55989 7148820 YP_002404041.1 CDS ygcE NC_011748.1 3117884 3119362 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; kinase 3117884..3119362 Escherichia coli 55989 7149395 YP_002404042.1 CDS ygcF NC_011748.1 3121284 3121955 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3121284..3121955) Escherichia coli 55989 7148809 YP_002404043.1 CDS ygcG NC_011748.1 3122416 3123120 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3122416..3123120 Escherichia coli 55989 7148810 YP_002404044.1 CDS EC55989_3053 NC_011748.1 3122930 3123196 D Evidence 6 : Doubtful CDS; hypothetical protein 3122930..3123196 Escherichia coli 55989 7148811 YP_002404045.1 CDS eno NC_011748.1 3123180 3124478 R enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis; phosphopyruvate hydratase complement(3123180..3124478) Escherichia coli 55989 7144862 YP_002404046.1 CDS pyrG NC_011748.1 3124566 3126203 R CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer; CTP synthetase complement(3124566..3126203) Escherichia coli 55989 7145998 YP_002404047.1 CDS mazG NC_011748.1 3126431 3127222 R functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era; nucleoside triphosphate pyrophosphohydrolase complement(3126431..3127222) Escherichia coli 55989 7147322 YP_002404048.1 CDS chpA NC_011748.1 3127293 3127628 R MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system; toxin ChpA complement(3127293..3127628) Escherichia coli 55989 7146791 YP_002404049.1 CDS chpR NC_011748.1 3127628 3127876 R part of the MazF-MazE toxin-antitoxin system; conteracts MazF; antitoxin MazE complement(3127628..3127876) Escherichia coli 55989 7145703 YP_002404050.1 CDS relA NC_011748.1 3127954 3130188 R (p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP; GDP/GTP pyrophosphokinase complement(3127954..3130188) Escherichia coli 55989 7145705 YP_002404051.1 CDS rumA NC_011748.1 3130236 3131537 R in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]; 23S rRNA 5-methyluridine methyltransferase complement(3130236..3131537) Escherichia coli 55989 7147369 YP_002404052.1 CDS EC55989_3062 NC_011748.1 3131952 3132227 D Evidence 2b : Function of strongly homologous gene; PubMedId : 375010, 1849492; Product type pe : enzyme; Insertion element IS1 protein insA 3131952..3132227 Escherichia coli 55989 7145595 YP_002404053.1 CDS EC55989_3063 NC_011748.1 3132146 3132649 D Evidence 2b : Function of strongly homologous gene; PubMedId : 273224, 375010, 1849492; Product type pe : enzyme; Insertion element IS1 1/5/6 protein insB 3132146..3132649 Escherichia coli 55989 7144863 YP_002404054.1 CDS gudD NC_011748.1 3135358 3136698 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233700, 9772162, 10762278, 13971911; Product type e : enzyme; (D)-glucarate dehydratase 1 complement(3135358..3136698) Escherichia coli 55989 7145596 YP_002404055.1 CDS gudP NC_011748.1 3138061 3139413 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278; Product type pt : transporter; D-glucarate transporter complement(3138061..3139413) Escherichia coli 55989 7146385 YP_002404056.1 CDS yqcA NC_011748.1 3139848 3140297 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(3139848..3140297) Escherichia coli 55989 7146383 YP_002404057.1 CDS truC NC_011748.1 3140315 3141097 R catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp; tRNA pseudouridine synthase C complement(3140315..3141097) Escherichia coli 55989 7149393 YP_002404058.1 CDS yqcC NC_011748.1 3141097 3141426 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3141097..3141426) Escherichia coli 55989 7147860 YP_002404059.1 CDS syd NC_011748.1 3142048 3142593 R SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function; SecY interacting protein Syd complement(3142048..3142593) Escherichia coli 55989 7145784 YP_002404060.1 CDS queF NC_011748.1 3142661 3143509 D catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis; 7-cyano-7-deazaguanine reductase 3142661..3143509 Escherichia coli 55989 7147742 YP_002404061.1 CDS ygdH NC_011748.1 3143621 3144985 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3143621..3144985 Escherichia coli 55989 7147333 YP_002404062.1 CDS sdaC NC_011748.1 3145542 3146831 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8752353, 8026499; Product type pt : transporter; serine transporter 3145542..3146831 Escherichia coli 55989 7148824 YP_002404063.1 CDS sdaB NC_011748.1 3146889 3148256 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193203, 93215657, 8385012; Product type e : enzyme; L-serine deaminase II 3146889..3148256 Escherichia coli 55989 7147614 YP_002404064.1 CDS xni NC_011748.1 3148278 3149123 D has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups; exonuclease IX 3148278..3149123 Escherichia coli 55989 7147613 YP_002404065.1 CDS fucO NC_011748.1 3149178 3150329 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 89291720, 2553671, 2661535, 2664711, 8385012; Product type e : enzyme; L-1,2-propanediol oxidoreductase complement(3149178..3150329) Escherichia coli 55989 7146042 YP_002404066.1 CDS fucA NC_011748.1 3150354 3151001 R catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate; L-fuculose phosphate aldolase complement(3150354..3151001) Escherichia coli 55989 7146226 YP_002404067.1 CDS fucP NC_011748.1 3151548 3152864 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2553671, 2664711, 7783647; Product type t : transporter; L-fucose transporter 3151548..3152864 Escherichia coli 55989 7146223 YP_002404068.1 CDS fucI NC_011748.1 3152897 3154672 D catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose; L-fucose isomerase 3152897..3154672 Escherichia coli 55989 7146227 YP_002404069.1 CDS fucK NC_011748.1 3154751 3156199 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88142551, 90036697, 2664711, 13905785; Product type e : enzyme; L-fuculokinase 3154751..3156199 Escherichia coli 55989 7146224 YP_002404070.1 CDS fucU NC_011748.1 3156201 3156623 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078, 12738765, 80049526, 2664711; Product type e : enzyme; L-fucose mutarotase 3156201..3156623 Escherichia coli 55989 7146225 YP_002404071.1 CDS fucR NC_011748.1 3156681 3157412 D regulates expression of genes involved in L-fucose utilization; DNA-binding transcriptional activator FucR 3156681..3157412 Escherichia coli 55989 7146229 YP_002404072.1 CDS ygdE NC_011748.1 3157456 3158556 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21188420, 7704273; Product type pe : enzyme; RNA 2'-O-ribose methyltransferase complement(3157456..3158556) Escherichia coli 55989 7146228 YP_002404073.1 CDS ygdD NC_011748.1 3158549 3158944 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7704273; Product type pm : membrane component; hypothetical protein complement(3158549..3158944) Escherichia coli 55989 7148823 YP_002404074.1 CDS gcvA NC_011748.1 3158963 3159880 R Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence; DNA-binding transcriptional activator GcvA complement(3158963..3159880) Escherichia coli 55989 7148822 YP_002404075.1 CDS ygdI NC_011748.1 3160231 3160458 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3160231..3160458) Escherichia coli 55989 7146275 YP_002404076.1 CDS csdA NC_011748.1 3160650 3161855 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15148362, 9278392, 10739946, 10829016; Product type e : enzyme; cysteine sulfinate desulfinase 3160650..3161855 Escherichia coli 55989 7148825 YP_002404077.1 CDS ygdK NC_011748.1 3161855 3162298 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; Fe-S metabolism protein (sufE-like) 3161855..3162298 Escherichia coli 55989 7145767 YP_002404078.1 CDS ygdL NC_011748.1 3162349 3163155 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3162349..3163155) Escherichia coli 55989 7148826 YP_002404079.1 CDS mltA NC_011748.1 3163232 3164329 R membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase A complement(3163232..3164329) Escherichia coli 55989 7148827 YP_002404080.1 CDS amiC NC_011748.1 3164907 3166160 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12787347, 21348478; Product type e : enzyme; N-acetylmuramoyl-L-alanine amidase complement(3164907..3166160) Escherichia coli 55989 7145343 YP_002404081.1 CDS argA NC_011748.1 3166392 3167723 D catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis; N-acetylglutamate synthase 3166392..3167723 Escherichia coli 55989 7145492 YP_002404082.1 CDS recD NC_011748.1 3167785 3169611 R helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit alpha complement(3167785..3169611) Escherichia coli 55989 7145524 YP_002404083.1 CDS recB NC_011748.1 3169611 3173153 R helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity; exonuclease V subunit beta complement(3169611..3173153) Escherichia coli 55989 7147360 YP_002404084.1 CDS ptr NC_011748.1 3173146 3176034 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91193232, 1570301, 3308636, 3534791, 3537960, 8099278; Product type e : enzyme; protease III complement(3173146..3176034) Escherichia coli 55989 7147358 YP_002404085.1 CDS recC NC_011748.1 3176210 3179578 R catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination; exonuclease V subunit gamma complement(3176210..3179578) Escherichia coli 55989 7147283 YP_002404086.1 CDS ppdC NC_011748.1 3179591 3179914 R Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein complement(3179591..3179914) Escherichia coli 55989 7147359 YP_002404087.1 CDS ygdB NC_011748.1 3179899 3180306 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3179899..3180306) Escherichia coli 55989 7147224 YP_002404088.1 CDS ppdB NC_011748.1 3180303 3180866 R Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein complement(3180303..3180866) Escherichia coli 55989 7148821 YP_002404089.1 CDS ppdA NC_011748.1 3180857 3181327 R Evidence 2b : Function of strongly homologous gene; PubMedId : 7934814; Product type e : enzyme; hypothetical protein complement(3180857..3181327) Escherichia coli 55989 7147223 YP_002404090.1 CDS thyA NC_011748.1 3181512 3182306 R ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived; thymidylate synthase complement(3181512..3182306) Escherichia coli 55989 7147222 YP_002404091.1 CDS lgt NC_011748.1 3182313 3183188 R transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein; prolipoprotein diacylglyceryl transferase complement(3182313..3183188) Escherichia coli 55989 7147799 YP_002404092.1 CDS ptsP NC_011748.1 3183339 3185585 R member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr; fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain complement(3183339..3185585) Escherichia coli 55989 7146698 YP_002404093.1 CDS nudH NC_011748.1 3185598 3186128 R hydrolyzes diadenosine polyphosphate; dinucleoside polyphosphate hydrolase complement(3185598..3186128) Escherichia coli 55989 7147291 YP_002404094.1 CDS mutH NC_011748.1 3186813 3187502 D MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair; DNA mismatch repair protein 3186813..3187502 Escherichia coli 55989 7147042 YP_002404095.1 CDS ygdQ NC_011748.1 3187571 3188284 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3187571..3188284 Escherichia coli 55989 7146931 YP_002404096.1 CDS ygdR NC_011748.1 3188422 3188640 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3188422..3188640 Escherichia coli 55989 7148828 YP_002404097.1 CDS tas NC_011748.1 3188748 3189788 D complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH; aldo-keto reductase 3188748..3189788 Escherichia coli 55989 7148829 YP_002404098.1 CDS ygeD NC_011748.1 3189820 3191013 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8300626; Product type pm : membrane component; lysophospholipid transporter LplT complement(3189820..3191013) Escherichia coli 55989 7147752 YP_002404099.1 CDS aas NC_011748.1 3191006 3193165 R Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1; bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase complement(3191006..3193165) Escherichia coli 55989 7148831 YP_002404100.1 CDS galR NC_011748.1 3193751 3194782 D controls transcription of galETKM; DNA-binding transcriptional regulator GalR 3193751..3194782 Escherichia coli 55989 7147074 YP_002404101.1 CDS lysA NC_011748.1 3194789 3196051 R catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding; diaminopimelate decarboxylase complement(3194789..3196051) Escherichia coli 55989 7146252 YP_002404102.1 CDS lysR NC_011748.1 3196173 3197108 D activates the transcription of the lysA gene encoding diaminopimelate decarboxylase; DNA-binding transcriptional regulator LysR 3196173..3197108 Escherichia coli 55989 7146755 YP_002404103.1 CDS ygeA NC_011748.1 3197095 3197787 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15135544; Product type pe : enzyme; racemase complement(3197095..3197787) Escherichia coli 55989 7146758 YP_002404104.1 CDS araE NC_011748.1 3197916 3199334 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7030324, 90239116, 91154204, 2836407, 3543693, 6319708; Product type t : transporter; arabinose transporter complement(3197916..3199334) Escherichia coli 55989 7148830 YP_002404105.1 CDS kduD NC_011748.1 3199649 3200410 R catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate; 2-deoxy-D-gluconate 3-dehydrogenase complement(3199649..3200410) Escherichia coli 55989 7145517 YP_002404106.1 CDS kduI NC_011748.1 3200440 3201276 R 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate; 5-keto-4-deoxyuronate isomerase complement(3200440..3201276) Escherichia coli 55989 7146664 YP_002404107.1 CDS yqeF NC_011748.1 3201563 3202744 R Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis; acetyl-CoA acetyltransferase complement(3201563..3202744) Escherichia coli 55989 7146665 YP_002404108.1 CDS yqeG NC_011748.1 3202999 3204228 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 3202999..3204228 Escherichia coli 55989 7149399 YP_002404109.1 CDS yqeH NC_011748.1 3204688 3205320 D Evidence 4 : Homologs of previously reported genes of unknown function; bipartite regulator domain 3204688..3205320 Escherichia coli 55989 7149400 YP_002404110.1 CDS yqeI NC_011748.1 3205654 3206463 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 3205654..3206463 Escherichia coli 55989 7149401 YP_002404111.1 CDS yqeJ NC_011748.1 3206456 3206938 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3206456..3206938 Escherichia coli 55989 7149402 YP_002404112.1 CDS yqeK NC_011748.1 3207087 3207512 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3207087..3207512) Escherichia coli 55989 7149403 YP_002404113.1 CDS ygeF NC_011748.1 3207706 3208143 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3207706..3208143 Escherichia coli 55989 7149404 YP_002404114.1 CDS ygeG NC_011748.1 3208421 3208912 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; chaperone 3208421..3208912 Escherichia coli 55989 7148832 YP_002404115.1 CDS ygeH NC_011748.1 3209247 3210623 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15150243; Product type pr : regulator; transcriptional regulator 3209247..3210623 Escherichia coli 55989 7148833 YP_002404116.1 CDS ygeI NC_011748.1 3210791 3211009 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3210791..3211009 Escherichia coli 55989 7148834 YP_002404117.1 CDS EC55989_3132 NC_011748.1 3211092 3211568 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; peptidoglycan-binding-like protein precursor 3211092..3211568 Escherichia coli 55989 7148835 YP_002404118.1 CDS ygeM NC_011748.1 3212466 3212897 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3212466..3212897) Escherichia coli 55989 7144867 YP_002404119.1 CDS EC55989_3136 NC_011748.1 3213114 3213695 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847; hypothetical protein complement(3213114..3213695) Escherichia coli 55989 7148836 YP_002404120.1 CDS eprK NC_011748.1 3213711 3214445 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pm : membrane component; Type III secretion system lipoprotein EprK complement(3213711..3214445) Escherichia coli 55989 7144868 YP_002404121.1 CDS eprI NC_011748.1 3214878 3215033 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pt : transporter; Type III secretion EprI protein complement(3214878..3215033) Escherichia coli 55989 7144869 YP_002404122.1 CDS eprH NC_011748.1 3215047 3216237 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; Type III secretion EprH protein complement(3215047..3216237) Escherichia coli 55989 7146013 YP_002404123.1 CDS EC55989_3141 NC_011748.1 3216486 3216986 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847; response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain 3216486..3216986 Escherichia coli 55989 7146012 YP_002404124.1 CDS EC55989_3142 NC_011748.1 3216988 3217281 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12791847; hypothetical protein 3216988..3217281 Escherichia coli 55989 7144870 YP_002404125.1 CDS EC55989_3146 NC_011748.1 3218508 3219275 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12791847; Product type pm : membrane component; Type III secretion protein EpaR complement(3218508..3219275) Escherichia coli 55989 7147684 YP_002404126.1 CDS spaP NC_011748.1 3219547 3220212 R part of a type III secretory system probably involved in invasion into eukaryotic cells; surface presentation of antigens protein SpaP complement(3219547..3220212) Escherichia coli 55989 7147681 YP_002404127.1 CDS EC55989_3151 NC_011748.1 3221281 3222933 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3221281..3222933) Escherichia coli 55989 7146010 YP_002404128.1 CDS ygeR NC_011748.1 3223277 3224032 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15150243; Product type r : regulator; Tetratricopeptide repeat transcriptional regulator complement(3223277..3224032) Escherichia coli 55989 7145379 YP_002404129.1 CDS xdhA NC_011748.1 3224486 3226744 D molybdenum cofactor-binding protein; participates in purine salvage; xanthine dehydrogenase subunit XdhA 3224486..3226744 Escherichia coli 55989 7148837 YP_002404130.1 CDS xdhB NC_011748.1 3226755 3227633 D FAD-binding subunit; with XdhA and XdhC participates in purine salvage; xanthine dehydrogenase subunit XdhB 3226755..3227633 Escherichia coli 55989 7147985 YP_002404131.1 CDS xdhC NC_011748.1 3227630 3228109 D iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage; xanthine dehydrogenase subunit XdhC 3227630..3228109 Escherichia coli 55989 7147986 YP_002404132.1 CDS ygeV NC_011748.1 3228149 3229927 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(3228149..3229927) Escherichia coli 55989 7147987 YP_002404133.1 CDS ygeW NC_011748.1 3230403 3231593 D Evidence 4 : Homologs of previously reported genes of unknown function; aspartate/ornithine carbamoyltransferase 3230403..3231593 Escherichia coli 55989 7148838 YP_002404134.1 CDS ygeX NC_011748.1 3231651 3232847 D catalyzes the formation of pyruvate from 2,3-diaminopropionate; diaminopropionate ammonia-lyase 3231651..3232847 Escherichia coli 55989 7148839 YP_002404135.1 CDS ygeY NC_011748.1 3232905 3234116 D Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases; peptidase 3232905..3234116 Escherichia coli 55989 7148840 YP_002404136.1 CDS hyuA NC_011748.1 3234169 3235554 D catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position; phenylhydantoinase 3234169..3235554 Escherichia coli 55989 7148841 YP_002404137.1 CDS yqeA NC_011748.1 3235602 3236534 D catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP; carbamate kinase 3235602..3236534 Escherichia coli 55989 7146526 YP_002404138.1 CDS yqeB NC_011748.1 3236575 3238200 R Evidence 4 : Homologs of previously reported genes of unknown function; NAD(P)-binding Rossman fold complement(3236575..3238200) Escherichia coli 55989 7149396 YP_002404139.1 CDS yqeC NC_011748.1 3238248 3239018 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3238248..3239018) Escherichia coli 55989 7149397 YP_002404140.1 CDS ygfJ NC_011748.1 3239121 3239699 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3239121..3239699 Escherichia coli 55989 7149398 YP_002404141.1 CDS ygfK NC_011748.1 3240021 3243119 D with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase; selenate reductase subunit YgfK 3240021..3243119 Escherichia coli 55989 7148848 YP_002404142.1 CDS ssnA NC_011748.1 3243122 3244450 D in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS; chlorohydrolase/aminohydrolase 3243122..3244450 Escherichia coli 55989 7148849 YP_002404143.1 CDS ygfM NC_011748.1 3244501 3245280 D with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain; selenate reductase subunit YgfM 3244501..3245280 Escherichia coli 55989 7147713 YP_002404144.1 CDS xdhD NC_011748.1 3245277 3248147 D with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration; selenate reductase subunit YgfN 3245277..3248147 Escherichia coli 55989 7148850 YP_002404145.1 CDS ygfO NC_011748.1 3248312 3249712 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20372655, 98213740; Product type pt : transporter; transporter 3248312..3249712 Escherichia coli 55989 7147988 YP_002404146.1 CDS guaD NC_011748.1 3249727 3251046 D Catalyzes the deamination of guanine; guanine deaminase 3249727..3251046 Escherichia coli 55989 7148851 YP_002404147.1 CDS ygfQ NC_011748.1 3251082 3252449 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 3251082..3252449 Escherichia coli 55989 7146381 YP_002404148.1 CDS ygfS NC_011748.1 3252485 3252973 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; oxidoreductase, 4Fe-4S ferredoxin-type subunit complement(3252485..3252973) Escherichia coli 55989 7148852 YP_002404149.1 CDS ygfT NC_011748.1 3252973 3254892 R unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic); oxidoreductase Fe-S binding subunit complement(3252973..3254892) Escherichia coli 55989 7148853 YP_002404150.1 CDS ygfU NC_011748.1 3255328 3256776 D Evidence 2b : Function of strongly homologous gene; PubMedId : 9098051; Product type t : transporter; transporter 3255328..3256776 Escherichia coli 55989 7148854 YP_002404151.1 CDS idi NC_011748.1 3257026 3257574 D catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate; isopentenyl-diphosphate delta-isomerase 3257026..3257574 Escherichia coli 55989 7148855 YP_002404152.1 CDS lysS NC_011748.1 3257617 3259134 R class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(3257617..3259134) Escherichia coli 55989 7146539 YP_002404153.1 CDS prfB NC_011748.1 3259144 3260242 R recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1; peptide chain release factor 2 complement(join(3259144..3260166,3260168..3260242)) Escherichia coli 55989 7146759 YP_002404154.1 CDS recJ NC_011748.1 3260333 3262066 R 5'-3' single-stranded-DNA-specific exonuclease; ssDNA exonuclease RecJ complement(3260333..3262066) Escherichia coli 55989 7147241 YP_002404155.1 CDS dsbC NC_011748.1 3262072 3262782 R DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity; thiol:disulfide interchange protein DsbC complement(3262072..3262782) Escherichia coli 55989 7147363 YP_002404156.1 CDS xerD NC_011748.1 3262807 3263703 R site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerD complement(3262807..3263703) Escherichia coli 55989 7145952 YP_002404157.1 CDS fldB NC_011748.1 3263815 3264336 D An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic; flavodoxin FldB 3263815..3264336 Escherichia coli 55989 7147990 YP_002404158.1 CDS ygfX NC_011748.1 3264376 3264783 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3264376..3264783) Escherichia coli 55989 7146123 YP_002404159.1 CDS ygfY NC_011748.1 3264764 3265030 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3264764..3265030) Escherichia coli 55989 7148856 YP_002404160.1 CDS ygfZ NC_011748.1 3265273 3266253 D physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator; global regulator 3265273..3266253 Escherichia coli 55989 7148857 YP_002404161.1 CDS EC55989_3185 NC_011748.1 3266506 3267486 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 3266506..3267486 Escherichia coli 55989 7148858 YP_002404162.1 CDS yqfA NC_011748.1 3267609 3268268 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; hemolysin, inner membrane subunit complement(3267609..3268268) Escherichia coli 55989 7144875 YP_002404163.1 CDS yqfB NC_011748.1 3268432 3268743 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3268432..3268743) Escherichia coli 55989 7149405 YP_002404164.1 CDS bglA NC_011748.1 3268782 3270221 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140; Product type e : enzyme; 6-phospho-beta-glucosidase 3268782..3270221 Escherichia coli 55989 7149406 YP_002404165.1 CDS ygfF NC_011748.1 3270278 3271021 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein complement(3270278..3271021) Escherichia coli 55989 7145616 YP_002404166.1 CDS gcvP NC_011748.1 3271282 3274155 R acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine; glycine dehydrogenase complement(3271282..3274155) Escherichia coli 55989 7148844 YP_002404167.1 CDS gcvH NC_011748.1 3274274 3274663 R part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor; glycine cleavage system protein H complement(3274274..3274663) Escherichia coli 55989 7146277 YP_002404168.1 CDS gcvT NC_011748.1 3274687 3275781 R catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein; glycine cleavage system aminomethyltransferase T complement(3274687..3275781) Escherichia coli 55989 7146276 YP_002404169.1 CDS visC NC_011748.1 3276229 3277431 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1339425; Product type pe : enzyme; hypothetical protein complement(3276229..3277431) Escherichia coli 55989 7146279 YP_002404170.1 CDS ubiH NC_011748.1 3277454 3278632 R Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone; 2-octaprenyl-6-methoxyphenyl hydroxylase complement(3277454..3278632) Escherichia coli 55989 7147948 YP_002404171.1 CDS pepP NC_011748.1 3278629 3279954 R exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide; proline aminopeptidase P II complement(3278629..3279954) Escherichia coli 55989 7147894 YP_002404172.1 CDS ygfB NC_011748.1 3279980 3280558 R the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown; hypothetical protein complement(3279980..3280558) Escherichia coli 55989 7147135 YP_002404173.1 CDS zapA NC_011748.1 3280726 3281055 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 412171; Product type cp : cell process; Z-ring-associated protein 3280726..3281055 Escherichia coli 55989 7148843 YP_002404174.1 CDS ygfA NC_011748.1 3281355 3281903 D ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function; ligase 3281355..3281903 Escherichia coli 55989 7147717 YP_002404175.1 CDS serA NC_011748.1 3282684 3283916 R catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate; D-3-phosphoglycerate dehydrogenase complement(3282684..3283916) Escherichia coli 55989 7147589 YP_002404176.1 CDS rpiA NC_011748.1 3284172 3284831 R Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway; ribose-5-phosphate isomerase A complement(3284172..3284831) Escherichia coli 55989 7147632 YP_002404177.1 CDS argP NC_011748.1 3285214 3286107 D specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport; chromosome replication initiation inhibitor protein 3285214..3286107 Escherichia coli 55989 7147462 YP_002404178.1 CDS argK NC_011748.1 3288448 3289443 D functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins; arginine/ornithine transport system ATPase 3288448..3289443 Escherichia coli 55989 7149262 YP_002404179.1 CDS ygfG NC_011748.1 3289454 3290239 D catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA; methylmalonyl-CoA decarboxylase 3289454..3290239 Escherichia coli 55989 7145532 YP_002404180.1 CDS ygfH NC_011748.1 3290263 3291741 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20233703; Product type e : enzyme; propionyl-CoA:succinate-CoA transferase 3290263..3291741 Escherichia coli 55989 7148845 YP_002404181.1 CDS ygfI NC_011748.1 3291738 3292634 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(3291738..3292634) Escherichia coli 55989 7148846 YP_002404182.1 CDS yggE NC_011748.1 3292801 3293541 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3292801..3293541) Escherichia coli 55989 7148847 YP_002404183.1 CDS argO NC_011748.1 3293634 3294269 R Involved in the export of arginine; arginine exporter protein complement(3293634..3294269) Escherichia coli 55989 7148861 YP_002404184.1 CDS mscS NC_011748.1 3294408 3295268 R participates in the regulation of osmotic pressure changes within the cel; mechanosensitive channel MscS complement(3294408..3295268) Escherichia coli 55989 7145533 YP_002404185.1 CDS fbaA NC_011748.1 3295626 3296705 R catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate; fructose-bisphosphate aldolase complement(3295626..3296705) Escherichia coli 55989 7146909 YP_002404186.1 CDS pgk NC_011748.1 3296920 3298083 R Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway; phosphoglycerate kinase complement(3296920..3298083) Escherichia coli 55989 7146062 YP_002404187.1 CDS epd NC_011748.1 3298133 3299152 R NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate; erythrose 4-phosphate dehydrogenase complement(3298133..3299152) Escherichia coli 55989 7147151 YP_002404188.1 CDS EC55989_3216 NC_011748.1 3299524 3299955 D Evidence 4 : Homologs of previously reported genes of unknown function; DNA-binding protein 3299524..3299955 Escherichia coli 55989 7146011 YP_002404189.1 CDS EC55989_3217 NC_011748.1 3299879 3300556 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; ABC-type transport system 3299879..3300556 Escherichia coli 55989 7144876 YP_002404190.1 CDS EC55989_3218 NC_011748.1 3300557 3301264 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; ABC-type transport system 3300557..3301264 Escherichia coli 55989 7144877 YP_002404191.1 CDS EC55989_3219 NC_011748.1 3301246 3301929 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; ABC transporter ATP-binding protein 3301246..3301929 Escherichia coli 55989 7144878 YP_002404192.1 CDS EC55989_3220 NC_011748.1 3301890 3302600 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; ABC transporter ATP-binding protein 3301890..3302600 Escherichia coli 55989 7144879 YP_002404193.1 CDS frcK NC_011748.1 3302572 3303285 R Evidence 4 : Homologs of previously reported genes of unknown function; fructose transport system kinase complement(3302572..3303285) Escherichia coli 55989 7144880 YP_002404194.1 CDS yggD NC_011748.1 3303282 3303791 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(3303282..3303791) Escherichia coli 55989 7148859 YP_002404195.1 CDS yggF NC_011748.1 3303813 3304778 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; fructose-1,6-bisphosphatase II-like protein complement(3303813..3304778) Escherichia coli 55989 7148860 YP_002404196.1 CDS yggP NC_011748.1 3304775 3306052 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; dehydrogenase complement(3304775..3306052) Escherichia coli 55989 7148862 YP_002404197.1 CDS cmtA NC_011748.1 3306067 3307455 R Evidence 2b : Function of strongly homologous gene; PubMedId : 8353127; Product type t : transporter; fused mannitol-specific PTS enzymes: IIB component ; IIC component complement(3306067..3307455) Escherichia coli 55989 7148869 YP_002404198.1 CDS cmtB NC_011748.1 3307483 3307926 R TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein; mannitol phosphotransferase subunit EIIA complement(3307483..3307926) Escherichia coli 55989 7145730 YP_002404199.1 CDS tktA NC_011748.1 3308240 3310231 R catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase; transketolase complement(3308240..3310231) Escherichia coli 55989 7145731 YP_002404200.1 CDS yggG NC_011748.1 3310509 3311267 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1310091; Product type pe : enzyme; peptidase 3310509..3311267 Escherichia coli 55989 7147804 YP_002404201.1 CDS speB NC_011748.1 3311473 3312393 R catalyzes the formation of putrescine from agmatine; agmatinase complement(3311473..3312393) Escherichia coli 55989 7148863 YP_002404202.1 CDS EC55989_3230 NC_011748.1 3312529 3313260 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3312529..3313260) Escherichia coli 55989 7147686 YP_002404203.1 CDS speA NC_011748.1 3313406 3315382 R catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis; arginine decarboxylase complement(3313406..3315382) Escherichia coli 55989 7144881 YP_002404204.1 CDS yqgB NC_011748.1 3315391 3315537 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3315391..3315537) Escherichia coli 55989 7147685 YP_002404205.1 CDS yqgC NC_011748.1 3315658 3315873 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3315658..3315873 Escherichia coli 55989 7149408 YP_002404206.1 CDS yqgD NC_011748.1 3315870 3316121 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(3315870..3316121) Escherichia coli 55989 7149409 YP_002404207.1 CDS metK NC_011748.1 3316177 3317331 D catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase; S-adenosylmethionine synthetase 3316177..3317331 Escherichia coli 55989 7149410 YP_002404208.1 CDS galP NC_011748.1 3317767 3319161 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9182541; Product type t : transporter; D-galactose transporter 3317767..3319161 Escherichia coli 55989 7146833 YP_002404209.1 CDS sprT NC_011748.1 3319238 3319735 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 7984428, 8113204; hypothetical protein 3319238..3319735 Escherichia coli 55989 7146251 YP_002404210.1 CDS endA NC_011748.1 3319830 3320537 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 72060411, 92335461, 4955462, 7867949, 8113204; Product type e : enzyme; DNA-specific endonuclease I 3319830..3320537 Escherichia coli 55989 7147696 YP_002404211.1 CDS yggJ NC_011748.1 3320617 3321348 D in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase; 16S ribosomal RNA methyltransferase RsmE 3320617..3321348 Escherichia coli 55989 7145997 YP_002404212.1 CDS gshB NC_011748.1 3321361 3322311 D catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione; glutathione synthetase 3321361..3322311 Escherichia coli 55989 7148865 YP_002404213.1 CDS yqgE NC_011748.1 3322420 3322983 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3322420..3322983 Escherichia coli 55989 7146374 YP_002404214.1 CDS yqgF NC_011748.1 3322983 3323399 D similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function; Holliday junction resolvase-like protein 3322983..3323399 Escherichia coli 55989 7149411 YP_002404215.1 CDS yggR NC_011748.1 3323575 3324555 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1676385; Product type t : transporter; transporter complement(3323575..3324555) Escherichia coli 55989 7149412 YP_002404216.1 CDS yggS NC_011748.1 3324573 3325277 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 3324573..3325277 Escherichia coli 55989 7148870 YP_002404217.1 CDS yggT NC_011748.1 3325295 3325861 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3325295..3325861 Escherichia coli 55989 7148871 YP_002404218.1 CDS yggU NC_011748.1 3325858 3326148 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12975589; hypothetical protein 3325858..3326148 Escherichia coli 55989 7148872 YP_002404219.1 CDS yggV NC_011748.1 3326156 3326749 D HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine; deoxyribonucleotide triphosphate pyrophosphatase 3326156..3326749 Escherichia coli 55989 7148873 YP_002404220.1 CDS yggW NC_011748.1 3326742 3327878 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 3326742..3327878 Escherichia coli 55989 7148874 YP_002404221.1 CDS yggM NC_011748.1 3328033 3329040 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3328033..3329040) Escherichia coli 55989 7148875 YP_002404222.1 CDS ansB NC_011748.1 3329157 3330203 R catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis; L-asparaginase II complement(3329157..3330203) Escherichia coli 55989 7148867 YP_002404223.1 CDS yggN NC_011748.1 3330379 3331098 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein complement(3330379..3331098) Escherichia coli 55989 7145503 YP_002404224.1 CDS yggL NC_011748.1 3331282 3331608 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3331282..3331608) Escherichia coli 55989 7148868 YP_002404225.1 CDS trmB NC_011748.1 3331608 3332327 R tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine; tRNA (guanine-N(7)-)-methyltransferase complement(3331608..3332327) Escherichia coli 55989 7148866 YP_002404226.1 CDS mutY NC_011748.1 3332488 3333540 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14730969, 20187555, 20316830, 20580749, 21438845, 90046892, 92409600, 9801309, 2001994, 2197596, 9846876; Product type e : enzyme; adenine DNA glycosylase 3332488..3333540 Escherichia coli 55989 7148864 YP_002404227.1 CDS yggX NC_011748.1 3333568 3333843 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594836, 10493123, 9298646, 9868784; Product type f : factor; hypothetical protein 3333568..3333843 Escherichia coli 55989 7146936 YP_002404228.1 CDS mltC NC_011748.1 3333908 3334987 D Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; murein transglycosylase C 3333908..3334987 Escherichia coli 55989 7148876 YP_002404229.1 CDS nupG NC_011748.1 3335189 3336445 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88029453, 90323001, 3311747; Product type t : transporter; nucleoside transporter 3335189..3336445 Escherichia coli 55989 7146865 YP_002404230.1 CDS speC NC_011748.1 3336495 3338630 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 87260820; Product type e : enzyme; ornithine decarboxylase complement(3336495..3338630) Escherichia coli 55989 7147057 YP_002404231.1 CDS yqgA NC_011748.1 3339028 3339735 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3339028..3339735 Escherichia coli 55989 7147687 YP_002404232.1 CDS int NC_011748.1 3340114 3341376 D Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Prophage integrase 3340114..3341376 Escherichia coli 55989 7145344 YP_002404233.1 CDS EC55989_3261 NC_011748.1 3341854 3342117 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3341854..3342117 Escherichia coli 55989 7146605 YP_002404234.1 CDS EC55989_3262 NC_011748.1 3342583 3343176 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3342583..3343176) Escherichia coli 55989 7147436 YP_002404235.1 CDS EC55989_3263 NC_011748.1 3343104 3343373 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3343104..3343373) Escherichia coli 55989 7144883 YP_002404236.1 CDS EC55989_3265 NC_011748.1 3343569 3346436 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Helicase 3343569..3346436 Escherichia coli 55989 7144884 YP_002404237.1 CDS EC55989_3266 NC_011748.1 3346438 3347442 D Evidence 4 : Homologs of previously reported genes of unknown function; ATPase 3346438..3347442 Escherichia coli 55989 7144885 YP_002404238.1 CDS EC55989_3267 NC_011748.1 3347452 3349839 D Evidence 4 : Homologs of previously reported genes of unknown function; serine protease 3347452..3349839 Escherichia coli 55989 7144886 YP_002404239.1 CDS EC55989_3268 NC_011748.1 3349849 3351477 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; DNA methylase N-4/N-6 3349849..3351477 Escherichia coli 55989 7144887 YP_002404240.1 CDS EC55989_3269 NC_011748.1 3351480 3354350 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; PstII restriction-modification enzyme Res subunit 3351480..3354350 Escherichia coli 55989 7144888 YP_002404241.1 CDS EC55989_3270 NC_011748.1 3354439 3354732 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3354439..3354732 Escherichia coli 55989 7144889 YP_002404242.1 CDS EC55989_3271 NC_011748.1 3354766 3355152 D Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase ORF A, IS3 family 3354766..3355152 Escherichia coli 55989 7144890 YP_002404243.1 CDS insI NC_011748.1 3355072 3356223 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094, 6092059; Product type e : enzyme; IS30 transposase; KpLE2 phage-like element complement(3355072..3356223) Escherichia coli 55989 7144891 YP_002404244.1 CDS EC55989_3273 NC_011748.1 3356354 3357505 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase 3356354..3357505 Escherichia coli 55989 7147435 YP_002404245.1 CDS EC55989_3274 NC_011748.1 3357615 3359183 R Evidence 4 : Homologs of previously reported genes of unknown function; transposase ORF1, IS66 family complement(3357615..3359183) Escherichia coli 55989 7144892 YP_002404246.1 CDS EC55989_3275 NC_011748.1 3359214 3359564 R Evidence 4 : Homologs of previously reported genes of unknown function; transposase ORF2, IS66 family complement(3359214..3359564) Escherichia coli 55989 7144893 YP_002404247.1 CDS EC55989_3276 NC_011748.1 3359561 3359998 R Evidence 4 : Homologs of previously reported genes of unknown function; transposase complement(3359561..3359998) Escherichia coli 55989 7144894 YP_002404248.1 CDS EC55989_3278 NC_011748.1 3360598 3360816 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3360598..3360816 Escherichia coli 55989 7144896 YP_002404249.1 CDS EC55989_3279 NC_011748.1 3360967 3365085 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; Serine protease pic precursor (ShMu) complement(3360967..3365085) Escherichia coli 55989 7144897 YP_002404250.1 CDS EC55989_3281 NC_011748.1 3366116 3367639 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; reverse transcriptase-like protein from prophage or plasmid complement(3366116..3367639) Escherichia coli 55989 7145310 YP_002404251.1 CDS EC55989_3282 NC_011748.1 3368231 3368803 R Evidence 7 : Gene remnant; Product type pe : enzyme; transposase ORF B (fragment), IS629 complement(3368231..3368803) Escherichia coli 55989 7144900 YP_002404252.1 CDS EC55989_3283 NC_011748.1 3369231 3371780 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3369231..3371780) Escherichia coli 55989 7144901 YP_002404253.1 CDS EC55989_3284 NC_011748.1 3371784 3375197 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3371784..3375197) Escherichia coli 55989 7144902 YP_002404254.1 CDS EC55989_3285 NC_011748.1 3375194 3375796 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3375194..3375796) Escherichia coli 55989 7144903 YP_002404255.1 CDS EC55989_3286 NC_011748.1 3375781 3376095 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3375781..3376095) Escherichia coli 55989 7144904 YP_002404256.1 CDS EC55989_3287 NC_011748.1 3376123 3377553 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3376123..3377553) Escherichia coli 55989 7144905 YP_002404257.1 CDS EC55989_3288 NC_011748.1 3377554 3378108 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3377554..3378108) Escherichia coli 55989 7144906 YP_002404258.1 CDS EC55989_3289 NC_011748.1 3378113 3379189 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3378113..3379189) Escherichia coli 55989 7144907 YP_002404259.1 CDS EC55989_3290 NC_011748.1 3379193 3379498 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3379193..3379498) Escherichia coli 55989 7144908 YP_002404260.1 CDS EC55989_3291 NC_011748.1 3379502 3379969 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3379502..3379969) Escherichia coli 55989 7144909 YP_002404261.1 CDS EC55989_3292 NC_011748.1 3379980 3381962 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3379980..3381962) Escherichia coli 55989 7144910 YP_002404262.1 CDS EC55989_3293 NC_011748.1 3381975 3382934 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3381975..3382934) Escherichia coli 55989 7144911 YP_002404263.1 CDS EC55989_3294 NC_011748.1 3382898 3384700 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3382898..3384700) Escherichia coli 55989 7144912 YP_002404264.1 CDS EC55989_3295 NC_011748.1 3384693 3385115 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3384693..3385115) Escherichia coli 55989 7144913 YP_002404265.1 CDS EC55989_3296 NC_011748.1 3385125 3385631 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3385125..3385631) Escherichia coli 55989 7144914 YP_002404266.1 CDS EC55989_3297 NC_011748.1 3385641 3387119 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3385641..3387119) Escherichia coli 55989 7144915 YP_002404267.1 CDS EC55989_3298 NC_011748.1 3387122 3387598 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3387122..3387598) Escherichia coli 55989 7144916 YP_002404268.1 CDS EC55989_3299 NC_011748.1 3388044 3389252 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L 3388044..3389252 Escherichia coli 55989 7147442 YP_002404269.1 CDS EC55989_3300 NC_011748.1 3389332 3389640 D Evidence 7 : Gene remnant; Product type pe : enzyme; transposase (fragment), IS630 family 3389332..3389640 Escherichia coli 55989 7144918 YP_002404270.1 CDS EC55989_3302 NC_011748.1 3389876 3390076 D Evidence 7 : Gene remnant; Product type pe : enzyme; transposase (fragment), IS630 family 3389876..3390076 Escherichia coli 55989 7144919 YP_002404271.1 CDS EC55989_3303 NC_011748.1 3390130 3390348 D Evidence 7 : Gene remnant; Product type pe : enzyme; transposase (fragment), IS630 family 3390130..3390348 Escherichia coli 55989 7144920 YP_002404272.1 CDS EC55989_3305 NC_011748.1 3390457 3390942 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3390457..3390942) Escherichia coli 55989 7144921 YP_002404273.1 CDS EC55989_3306 NC_011748.1 3390836 3391042 R Evidence 4 : Homologs of previously reported genes of unknown function; polyketide synthase pksM (fragment) complement(3390836..3391042) Escherichia coli 55989 7144922 YP_002404274.1 CDS EC55989_3307 NC_011748.1 3391214 3391609 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3391214..3391609 Escherichia coli 55989 7144923 YP_002404275.1 CDS EC55989_3308 NC_011748.1 3391435 3391632 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3391435..3391632 Escherichia coli 55989 7144924 YP_002404276.1 CDS EC55989_3309 NC_011748.1 3391663 3391986 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3391663..3391986) Escherichia coli 55989 7144925 YP_002404277.1 CDS EC55989_3310 NC_011748.1 3392052 3392696 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3392052..3392696) Escherichia coli 55989 7144926 YP_002404278.1 CDS EC55989_3311 NC_011748.1 3392717 3393025 R Evidence 4 : Homologs of previously reported genes of unknown function; transcriptional regulator complement(3392717..3393025) Escherichia coli 55989 7144927 YP_002404279.1 CDS ibrB NC_011748.1 3393065 3393709 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; transcriptional regulator IbrB complement(3393065..3393709) Escherichia coli 55989 7144928 YP_002404280.1 CDS ibrA NC_011748.1 3393694 3394926 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12057959; Product type r : regulator; immunoglobulin-binding regulator complement(3393694..3394926) Escherichia coli 55989 7146536 YP_002404281.1 CDS EC55989_3314 NC_011748.1 3394967 3395797 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3394967..3395797) Escherichia coli 55989 7146534 YP_002404282.1 CDS EC55989_3315 NC_011748.1 3396575 3397942 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3396575..3397942) Escherichia coli 55989 7144929 YP_002404283.1 CDS EC55989_3316 NC_011748.1 3398367 3400154 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; UvrD/REP helicase complement(3398367..3400154) Escherichia coli 55989 7144930 YP_002404284.1 CDS EC55989_3317 NC_011748.1 3400348 3401514 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3400348..3401514) Escherichia coli 55989 7144931 YP_002404285.1 CDS EC55989_3318 NC_011748.1 3401747 3402160 R hypothetical protein complement(3401747..3402160) Escherichia coli 55989 7144932 YP_002404286.1 CDS EC55989_3319 NC_011748.1 3402305 3402739 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3402305..3402739) Escherichia coli 55989 7144933 YP_002404287.1 CDS EC55989_3320 NC_011748.1 3402739 3403275 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3402739..3403275) Escherichia coli 55989 7144934 YP_002404288.1 CDS EC55989_3321 NC_011748.1 3403256 3404356 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3403256..3404356) Escherichia coli 55989 7144935 YP_002404289.1 CDS EC55989_3322 NC_011748.1 3404311 3406074 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3404311..3406074) Escherichia coli 55989 7144936 YP_002404290.1 CDS EC55989_3323 NC_011748.1 3406082 3406879 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3406082..3406879) Escherichia coli 55989 7144937 YP_002404291.1 CDS EC55989_3324 NC_011748.1 3406776 3408374 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3406776..3408374) Escherichia coli 55989 7144938 YP_002404292.1 CDS EC55989_3325 NC_011748.1 3408374 3411763 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3408374..3411763) Escherichia coli 55989 7144939 YP_002404293.1 CDS EC55989_3326 NC_011748.1 3411756 3412904 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3411756..3412904) Escherichia coli 55989 7144940 YP_002404294.1 CDS EC55989_3327 NC_011748.1 3412908 3413174 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3412908..3413174) Escherichia coli 55989 7144941 YP_002404295.1 CDS EC55989_3328 NC_011748.1 3413206 3413883 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3413206..3413883) Escherichia coli 55989 7144942 YP_002404296.1 CDS EC55989_3329 NC_011748.1 3414027 3414704 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3414027..3414704) Escherichia coli 55989 7144943 YP_002404297.1 CDS EC55989_3330 NC_011748.1 3414724 3416406 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3414724..3416406) Escherichia coli 55989 7144944 YP_002404298.1 CDS EC55989_3331 NC_011748.1 3416403 3418928 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3416403..3418928) Escherichia coli 55989 7144945 YP_002404299.1 CDS EC55989_3333 NC_011748.1 3419451 3420026 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3419451..3420026) Escherichia coli 55989 7144946 YP_002404300.1 CDS EC55989_3334 NC_011748.1 3420014 3422680 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; chaperone clpB complement(3420014..3422680) Escherichia coli 55989 7144947 YP_002404301.1 CDS EC55989_3335 NC_011748.1 3422840 3423331 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3422840..3423331) Escherichia coli 55989 7144948 YP_002404302.1 CDS EC55989_3336 NC_011748.1 3423337 3425163 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3423337..3425163) Escherichia coli 55989 7144949 YP_002404303.1 CDS EC55989_3337 NC_011748.1 3425070 3425789 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3425070..3425789) Escherichia coli 55989 7144950 YP_002404304.1 CDS EC55989_3338 NC_011748.1 3425720 3427057 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3425720..3427057) Escherichia coli 55989 7144951 YP_002404305.1 CDS EC55989_3339 NC_011748.1 3427073 3428617 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3427073..3428617) Escherichia coli 55989 7144952 YP_002404306.1 CDS EC55989_3340 NC_011748.1 3428639 3429160 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3428639..3429160) Escherichia coli 55989 7144953 YP_002404307.1 CDS EC55989_3342 NC_011748.1 3429643 3429834 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3429643..3429834 Escherichia coli 55989 7144954 YP_002404308.1 CDS EC55989_3343 NC_011748.1 3429887 3430195 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3429887..3430195) Escherichia coli 55989 7144955 YP_002404309.1 CDS EC55989_3344 NC_011748.1 3430216 3430875 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3430216..3430875) Escherichia coli 55989 7144956 YP_002404310.1 CDS EC55989_3345 NC_011748.1 3431148 3431621 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3431148..3431621) Escherichia coli 55989 7144957 YP_002404311.1 CDS EC55989_3346 NC_011748.1 3431557 3431946 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3431557..3431946) Escherichia coli 55989 7144958 YP_002404312.1 CDS EC55989_3348 NC_011748.1 3432108 3432677 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3432108..3432677) Escherichia coli 55989 7144959 YP_002404313.1 CDS EC55989_3349 NC_011748.1 3432881 3433054 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 3432881..3433054 Escherichia coli 55989 7144960 YP_002404314.1 CDS EC55989_3350 NC_011748.1 3432924 3433127 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(3432924..3433127) Escherichia coli 55989 7144961 YP_002404315.1 CDS EC55989_3351 NC_011748.1 3433294 3433506 R Evidence 2b : Function of strongly homologous gene; PubMedId : 1956303, 8145648, 1484495; Product type f : factor; hemolysin expression-modulating protein complement(3433294..3433506) Escherichia coli 55989 7144962 YP_002404316.1 CDS EC55989_3353 NC_011748.1 3434470 3435069 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3434470..3435069 Escherichia coli 55989 7144964 YP_002404317.1 CDS EC55989_3354 NC_011748.1 3435055 3435291 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3435055..3435291) Escherichia coli 55989 7144965 YP_002404318.1 CDS EC55989_3355 NC_011748.1 3436564 3437583 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3436564..3437583 Escherichia coli 55989 7144966 YP_002404319.1 CDS EC55989_3356 NC_011748.1 3437654 3438565 D Evidence 4 : Homologs of previously reported genes of unknown function; GTPase 3437654..3438565 Escherichia coli 55989 7144967 YP_002404320.1 CDS flu NC_011748.1 3438893 3442018 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20392470, 97257509, 99212225, 2661530, 9298646; Product type h : extrachromosomal origin; antigen 43 (Ag43) phase-variable biofilm formation autotransporter; CP4-44 prophage 3438893..3442018 Escherichia coli 55989 7146635 YP_002404321.1 CDS EC55989_3358 NC_011748.1 3442133 3444655 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; membrane protein, yeeR 3442133..3444655 Escherichia coli 55989 7146163 YP_002404322.1 CDS EC55989_3359 NC_011748.1 3444731 3445186 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3444731..3445186 Escherichia coli 55989 7144969 YP_002404323.1 CDS EC55989_3360 NC_011748.1 3445265 3445498 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3445265..3445498 Escherichia coli 55989 7144970 YP_002404324.1 CDS EC55989_3361 NC_011748.1 3445598 3446416 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3445598..3446416 Escherichia coli 55989 7144971 YP_002404325.1 CDS yeeS NC_011748.1 3447237 3447683 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : factor; DNA repair protein; CP4-44 prophage 3447237..3447683 Escherichia coli 55989 7144973 YP_002404326.1 CDS yeeT NC_011748.1 3447770 3447991 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; CP4-44 prophage 3447770..3447991 Escherichia coli 55989 7148605 YP_002404327.1 CDS yeeU NC_011748.1 3448071 3448448 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; antitoxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 3448071..3448448 Escherichia coli 55989 7148609 YP_002404328.1 CDS yeeV NC_011748.1 3448390 3448872 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type f : factor; toxin of the YeeV-YeeU toxin-antitoxin system 3448390..3448872 Escherichia coli 55989 7148613 YP_002404329.1 CDS yeeW NC_011748.1 3448869 3449291 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3448869..3449291 Escherichia coli 55989 7148617 YP_002404330.1 CDS EC55989_3368 NC_011748.1 3449376 3450218 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9987116; hypothetical protein 3449376..3450218 Escherichia coli 55989 7148620 YP_002404331.1 CDS yghD NC_011748.1 3450499 3451035 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; general secretion pathway protein YghD complement(3450499..3451035) Escherichia coli 55989 7144974 YP_002404332.1 CDS yghE NC_011748.1 3451037 3452215 R similar to general secretory pathway protein L; GspL-like protein complement(3451037..3452215) Escherichia coli 55989 7148879 YP_002404333.1 CDS EC55989_3371 NC_011748.1 3452212 3453189 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; type II secretion protein (GspK-like) complement(3452212..3453189) Escherichia coli 55989 7148880 YP_002404334.1 CDS EC55989_3372 NC_011748.1 3453192 3453791 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3453192..3453791) Escherichia coli 55989 7144975 YP_002404335.1 CDS EC55989_3373 NC_011748.1 3453788 3454159 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; type II secretion protein (GspI-like) complement(3453788..3454159) Escherichia coli 55989 7144976 YP_002404336.1 CDS EC55989_3374 NC_011748.1 3454156 3454719 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3454156..3454719) Escherichia coli 55989 7144977 YP_002404337.1 CDS EC55989_3375 NC_011748.1 3454723 3455205 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; general secretion pathway protein G precursor (epsG-like) complement(3454723..3455205) Escherichia coli 55989 7144978 YP_002404338.1 CDS epsF NC_011748.1 3455195 3456418 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; General secretion pathway protein F complement(3455195..3456418) Escherichia coli 55989 7144979 YP_002404339.1 CDS epsE NC_011748.1 3456418 3457911 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein E complement(3456418..3457911) Escherichia coli 55989 7146017 YP_002404340.1 CDS epsD NC_011748.1 3457911 3459971 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; general secretion pathway protein D complement(3457911..3459971) Escherichia coli 55989 7146016 YP_002404341.1 CDS yghF NC_011748.1 3460001 3460960 R part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm; type II secretion protein GspC complement(3460001..3460960) Escherichia coli 55989 7146015 YP_002404342.1 CDS yghG NC_011748.1 3460978 3461388 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3460978..3461388) Escherichia coli 55989 7148881 YP_002404343.1 CDS pppA NC_011748.1 3461454 3462263 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98175453; Product type e : enzyme; bifunctional prepilin leader peptidase and methylase complement(3461454..3462263) Escherichia coli 55989 7148882 YP_002404344.1 CDS yghJ NC_011748.1 3462403 3466986 R Evidence 2b : Function of strongly homologous gene; PubMedId : 1644747; Product type lp : lipoprotein; inner membrane lipoprotein complement(3462403..3466986) Escherichia coli 55989 7147233 YP_002404345.1 CDS EC55989_3383 NC_011748.1 3467116 3467328 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3467116..3467328 Escherichia coli 55989 7148883 YP_002404346.1 CDS yghK NC_011748.1 3467454 3469136 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11785976, 21178909, 11283302; Product type t : transporter; glycolate transporter complement(3467454..3469136) Escherichia coli 55989 7144980 YP_002404347.1 CDS glcB NC_011748.1 3469492 3471663 R catalyzes the formation of malate from glyoxylate and acetyl-CoA; malate synthase G complement(3469492..3471663) Escherichia coli 55989 7148884 YP_002404348.1 CDS glcG NC_011748.1 3471685 3472089 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3471685..3472089) Escherichia coli 55989 7146285 YP_002404349.1 CDS glcF NC_011748.1 3472094 3473317 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type c : carrier; glycolate oxidase iron-sulfur subunit complement(3472094..3473317) Escherichia coli 55989 7146290 YP_002404350.1 CDS glcE NC_011748.1 3473328 3474380 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase FAD binding subunit complement(3473328..3474380) Escherichia coli 55989 7146289 YP_002404351.1 CDS glcD NC_011748.1 3474380 3475879 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96178972, 8606183; Product type e : enzyme; glycolate oxidase subunit GlcD complement(3474380..3475879) Escherichia coli 55989 7146288 YP_002404352.1 CDS EC55989_3391 NC_011748.1 3476720 3477223 R Evidence 2b : Function of strongly homologous gene; PubMedId : 273224, 375010, 1849492; Product type pe : enzyme; transposase ORF B IS1 complement(3476720..3477223) Escherichia coli 55989 7146286 YP_002404353.1 CDS insA NC_011748.1 3477142 3477417 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094; Product type h : extrachromosomal origin; IS1 repressor protein InsA complement(3477142..3477417) Escherichia coli 55989 7144981 YP_002404354.1 CDS EC55989_3394 NC_011748.1 3477551 3478723 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; 8-amino-7-oxononanoate synthase 3477551..3478723 Escherichia coli 55989 7144982 YP_002404355.1 CDS EC55989_3395 NC_011748.1 3478758 3479918 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3478758..3479918) Escherichia coli 55989 7144983 YP_002404356.1 CDS EC55989_3396 NC_011748.1 3479834 3480904 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3479834..3480904) Escherichia coli 55989 7144984 YP_002404357.1 CDS EC55989_3397 NC_011748.1 3480935 3481498 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator complement(3480935..3481498) Escherichia coli 55989 7144985 YP_002404358.1 CDS EC55989_3398 NC_011748.1 3481507 3482331 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3481507..3482331) Escherichia coli 55989 7144986 YP_002404359.1 CDS EC55989_3399 NC_011748.1 3482331 3483680 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; membrane protein, conserved protein complement(3482331..3483680) Escherichia coli 55989 7144987 YP_002404360.1 CDS yghR NC_011748.1 3483726 3484484 R Evidence 4 : Homologs of previously reported genes of unknown function; nucleoside triphosphate hydrolase domain complement(3483726..3484484) Escherichia coli 55989 7144988 YP_002404361.1 CDS yghS NC_011748.1 3484516 3485229 R Evidence 4 : Homologs of previously reported genes of unknown function; nucleoside triphosphate hydrolase domain complement(3484516..3485229) Escherichia coli 55989 7148885 YP_002404362.1 CDS yghT NC_011748.1 3485403 3486095 D Evidence 4 : Homologs of previously reported genes of unknown function; nucleoside triphosphate hydrolase domain 3485403..3486095 Escherichia coli 55989 7148886 YP_002404363.1 CDS pitB NC_011748.1 3486144 3487643 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21336523, 21382172, 7775463; Product type t : transporter; phosphate transporter complement(3486144..3487643) Escherichia coli 55989 7148887 YP_002404364.1 CDS gss NC_011748.1 3487935 3489794 R catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction; bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase complement(3487935..3489794) Escherichia coli 55989 7147192 YP_002404365.1 CDS yghU NC_011748.1 3489999 3490865 D YghU; B2989; one of eight glutathione transferase proteins from E. coli; glutathione S-transferase 3489999..3490865 Escherichia coli 55989 7146376 YP_002404366.1 CDS EC55989_3406 NC_011748.1 3491165 3492145 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 3491165..3492145 Escherichia coli 55989 7148888 YP_002404367.1 CDS hybG NC_011748.1 3492267 3492515 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92215587, 94292472, 8021226; Product type pf : factor; hydrogenase 2 accessory protein HypG complement(3492267..3492515) Escherichia coli 55989 7144989 YP_002404368.1 CDS hybF NC_011748.1 3492528 3492869 R plays a role in hydrogenase nickel cofactor insertion; hydrogenase nickel incorporation protein HybF complement(3492528..3492869) Escherichia coli 55989 7146494 YP_002404369.1 CDS hybE NC_011748.1 3492862 3493350 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292472, 8021226; Product type f : factor; hydrogenase 2-specific chaperone complement(3492862..3493350) Escherichia coli 55989 7146493 YP_002404370.1 CDS hybD NC_011748.1 3493343 3493837 R protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC); hydrogenase 2 maturation endopeptidase complement(3493343..3493837) Escherichia coli 55989 7146492 YP_002404371.1 CDS hybC NC_011748.1 3493837 3495540 R involved in hydrogen uptake; hydrogenase 2 large subunit complement(3493837..3495540) Escherichia coli 55989 7146491 YP_002404372.1 CDS hybB NC_011748.1 3495537 3496715 R HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits; hydrogenase 2 b cytochrome subunit complement(3495537..3496715) Escherichia coli 55989 7146490 YP_002404373.1 CDS hybA NC_011748.1 3496705 3497691 R Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2; hydrogenase 2 protein HybA complement(3496705..3497691) Escherichia coli 55989 7146489 YP_002404374.1 CDS hybO NC_011748.1 3497694 3498812 R involved in hydrogen uptake; hydrogenase 2 small subunit complement(3497694..3498812) Escherichia coli 55989 7146488 YP_002404375.1 CDS EC55989_3415 NC_011748.1 3498819 3499004 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3498819..3499004) Escherichia coli 55989 7146495 YP_002404376.1 CDS yghW NC_011748.1 3499001 3499288 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3499001..3499288) Escherichia coli 55989 7144990 YP_002404377.1 CDS EC55989_3417 NC_011748.1 3499407 3500333 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3499407..3500333) Escherichia coli 55989 7148889 YP_002404378.1 CDS yghZ NC_011748.1 3500451 3501491 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12583903; Product type e : enzyme; aldo/keto reductase 3500451..3501491 Escherichia coli 55989 7144991 YP_002404379.1 CDS yqhA NC_011748.1 3501531 3502025 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(3501531..3502025) Escherichia coli 55989 7148890 YP_002404380.1 CDS yghA NC_011748.1 3502216 3503100 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase 3502216..3503100 Escherichia coli 55989 7149413 YP_002404381.1 CDS exbD NC_011748.1 3503139 3503564 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbD complement(3503139..3503564) Escherichia coli 55989 7148877 YP_002404382.1 CDS exbB NC_011748.1 3503571 3504305 R membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell; biopolymer transport protein ExbB complement(3503571..3504305) Escherichia coli 55989 7146041 YP_002404383.1 CDS EC55989_3424 NC_011748.1 3504298 3504453 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3504298..3504453) Escherichia coli 55989 7146040 YP_002404384.1 CDS metC NC_011748.1 3504557 3505744 D catalyzes the formation of L-homocysteine from cystathionine; cystathionine beta-lyase 3504557..3505744 Escherichia coli 55989 7144992 YP_002404385.1 CDS yghB NC_011748.1 3505884 3506543 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3505884..3506543 Escherichia coli 55989 7146826 YP_002404386.1 CDS yqhC NC_011748.1 3506583 3507539 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(3506583..3507539) Escherichia coli 55989 7148878 YP_002404387.1 CDS yqhD NC_011748.1 3507676 3508839 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15327949; Product type e : enzyme; alcohol dehydrogenase 3507676..3508839 Escherichia coli 55989 7149414 YP_002404388.1 CDS dkgA NC_011748.1 3508944 3509771 D methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate; 2,5-diketo-D-gluconate reductase A 3508944..3509771 Escherichia coli 55989 7149415 YP_002404389.1 CDS yqhG NC_011748.1 3509971 3510897 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3509971..3510897 Escherichia coli 55989 7145924 YP_002404390.1 CDS yqhH NC_011748.1 3510948 3511205 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; outer membrane lipoprotein 3510948..3511205 Escherichia coli 55989 7149416 YP_002404391.1 CDS ygiQ NC_011748.1 3511248 3513467 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3511248..3513467) Escherichia coli 55989 7149417 YP_002404392.1 CDS sufI NC_011748.1 3513578 3514990 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88314889, 1557036, 9298646; Product type r : regulator; repressor protein for FtsI complement(3513578..3514990) Escherichia coli 55989 7148898 YP_002404393.1 CDS plsC NC_011748.1 3515065 3515802 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212294, 1557036; Product type e : enzyme; 1-acyl-sn-glycerol-3-phosphate acyltransferase complement(3515065..3515802) Escherichia coli 55989 7147735 YP_002404394.1 CDS EC55989_3435 NC_011748.1 3515850 3516005 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3515850..3516005) Escherichia coli 55989 7147196 YP_002404395.1 CDS parC NC_011748.1 3516035 3518293 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit A complement(3516035..3518293) Escherichia coli 55989 7144993 YP_002404396.1 CDS ygiV NC_011748.1 3518839 3519321 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator complement(3518839..3519321) Escherichia coli 55989 7147115 YP_002404397.1 CDS ygiW NC_011748.1 3519374 3519766 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9298646; hypothetical protein complement(3519374..3519766) Escherichia coli 55989 7148899 YP_002404398.1 CDS qseB NC_011748.1 3519918 3520577 D response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes; DNA-binding transcriptional regulator QseB 3519918..3520577 Escherichia coli 55989 7148900 YP_002404399.1 CDS qseC NC_011748.1 3520574 3521923 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21927389; Product type r : regulator; sensor protein QseC 3520574..3521923 Escherichia coli 55989 7147329 YP_002404400.1 CDS ygiZ NC_011748.1 3521969 3522301 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(3521969..3522301) Escherichia coli 55989 7147330 YP_002404401.1 CDS mdaB NC_011748.1 3522620 3523201 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96004656, 96217538; Product type c : carrier; NADPH quinone reductase 3522620..3523201 Escherichia coli 55989 7148901 YP_002404402.1 CDS ygiN NC_011748.1 3523232 3523546 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10493123, 9298646, 9600841, 9868784; Product type e : enzyme; quinol monooxygenase 3523232..3523546 Escherichia coli 55989 7146793 YP_002404403.1 CDS parE NC_011748.1 3523594 3525486 R decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling; DNA topoisomerase IV subunit B complement(3523594..3525486) Escherichia coli 55989 7148896 YP_002404404.1 CDS yqiA NC_011748.1 3525515 3526096 R Displays esterase activity toward palmitoyl-CoA and pNP-butyrate; esterase YqiA complement(3525515..3526096) Escherichia coli 55989 7147116 YP_002404405.1 CDS cpdA NC_011748.1 3526096 3526923 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96411758; Product type e : enzyme; cyclic 3',5'-adenosine monophosphate phosphodiesterase complement(3526096..3526923) Escherichia coli 55989 7149418 YP_002404406.1 CDS yqiB NC_011748.1 3526948 3527370 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein complement(3526948..3527370) Escherichia coli 55989 7145744 YP_002404407.1 CDS nudF NC_011748.1 3527371 3528000 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose pyrophosphatase complement(3527371..3528000) Escherichia coli 55989 7149419 YP_002404408.1 CDS tolC NC_011748.1 3528205 3529686 D trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell; outer membrane channel protein 3528205..3529686 Escherichia coli 55989 7147040 YP_002404409.1 CDS ygiB NC_011748.1 3529930 3530505 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 3529930..3530505 Escherichia coli 55989 7147814 YP_002404410.1 CDS ygiC NC_011748.1 3530511 3531671 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 3530511..3531671 Escherichia coli 55989 7148891 YP_002404411.1 CDS zupT NC_011748.1 3531709 3532524 R seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine; hypothetical protein complement(3531709..3532524) Escherichia coli 55989 7148892 YP_002404412.1 CDS ygiE NC_011748.1 3532640 3533413 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11790762, 1314093; Product type t : transporter; zinc transporter ZupT 3532640..3533413 Escherichia coli 55989 7149498 YP_002404413.1 CDS EC55989_3456 NC_011748.1 3533471 3533665 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3533471..3533665) Escherichia coli 55989 7148893 YP_002404414.1 CDS ribB NC_011748.1 3533902 3534555 R DHBP synthase; functions during riboflavin biosynthesis; 3,4-dihydroxy-2-butanone 4-phosphate synthase complement(3533902..3534555) Escherichia coli 55989 7144994 YP_002404415.1 CDS yqiC NC_011748.1 3534929 3535219 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3534929..3535219 Escherichia coli 55989 7145311 YP_002404416.1 CDS ygiL NC_011748.1 3535502 3536053 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial protein 3535502..3536053 Escherichia coli 55989 7149420 YP_002404417.1 CDS yqiG NC_011748.1 3536104 3538617 D Evidence 2b : Function of strongly homologous gene; Product type f : factor; outer membrane usher protein 3536104..3538617 Escherichia coli 55989 7148895 YP_002404418.1 CDS yqiH NC_011748.1 3538633 3539382 D Evidence 2b : Function of strongly homologous gene; Product type f : factor; periplasmic pilin chaperone 3538633..3539382 Escherichia coli 55989 7149421 YP_002404419.1 CDS yqiI NC_011748.1 3539384 3540448 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3539384..3540448 Escherichia coli 55989 7149422 YP_002404420.1 CDS glgS NC_011748.1 3540491 3540691 R Involved in glycogen synthesis. May be involved in glycogen priming; glycogen synthesis protein GlgS complement(3540491..3540691) Escherichia coli 55989 7149423 YP_002404421.1 CDS yqiJ NC_011748.1 3540960 3541589 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3540960..3541589 Escherichia coli 55989 7146296 YP_002404422.1 CDS yqiK NC_011748.1 3541616 3543277 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3541616..3543277 Escherichia coli 55989 7149424 YP_002404423.1 CDS rfaE NC_011748.1 3544071 3545504 R catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose; bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase complement(3544071..3545504) Escherichia coli 55989 7145312 YP_002404424.1 CDS glnE NC_011748.1 3545552 3548392 R catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme; bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase complement(3545552..3548392) Escherichia coli 55989 7147374 YP_002404425.1 CDS ygiF NC_011748.1 3548415 3549716 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8412694; Product type pe : enzyme; adenylate cyclase complement(3548415..3549716) Escherichia coli 55989 7146305 YP_002404426.1 CDS EC55989_3469 NC_011748.1 3549733 3549939 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3549733..3549939) Escherichia coli 55989 7148894 YP_002404427.1 CDS htrG NC_011748.1 3549958 3550578 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11274153; Product type pr : regulator; signal transduction protein 3549958..3550578 Escherichia coli 55989 7144995 YP_002404428.1 CDS cca NC_011748.1 3550642 3551880 D catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases; multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase 3550642..3551880 Escherichia coli 55989 7146478 YP_002404429.1 CDS bacA NC_011748.1 3552043 3552864 R BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell; undecaprenyl pyrophosphate phosphatase complement(3552043..3552864) Escherichia coli 55989 7145671 YP_002404430.1 CDS folB NC_011748.1 3552955 3553323 R catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin; bifunctional dihydroneopterin aldolase/dihydroneopterin triphosphate 2'-epimerase complement(3552955..3553323) Escherichia coli 55989 7145592 YP_002404431.1 CDS plsY NC_011748.1 3553428 3554045 D involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX; glycerol-3-phosphate acyltransferase PlsY 3553428..3554045 Escherichia coli 55989 7146169 YP_002404432.1 CDS ygiP NC_011748.1 3554058 3554990 R activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol; transcriptional activator TtdR complement(3554058..3554990) Escherichia coli 55989 7147198 YP_002404433.1 CDS ttdA NC_011748.1 3555197 3556108 D Involved in the tartrate degradation pathway; tartrate dehydratase subunit alpha 3555197..3556108 Escherichia coli 55989 7148897 YP_002404434.1 CDS ttdB NC_011748.1 3556105 3556710 D Involved in the tartrate degradation pathway; L(+)-tartrate dehydratase subunit beta 3556105..3556710 Escherichia coli 55989 7147869 YP_002404435.1 CDS ygjE NC_011748.1 3556759 3558222 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; tartrate:succinate antiporter 3556759..3558222 Escherichia coli 55989 7147870 YP_002404436.1 CDS gcp NC_011748.1 3558265 3559278 R in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity; DNA-binding/iron metalloprotein/AP endonuclease complement(3558265..3559278) Escherichia coli 55989 7148902 YP_002404437.1 CDS rpsU NC_011748.1 3559515 3559730 D a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA; 30S ribosomal protein S21 3559515..3559730 Escherichia coli 55989 7146273 YP_002404438.1 CDS dnaG NC_011748.1 3559841 3561586 D synthesizes RNA primers at the replication forks; DNA primase 3559841..3561586 Escherichia coli 55989 7147525 YP_002404439.1 CDS rpoD NC_011748.1 3561781 3563622 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria; RNA polymerase sigma factor RpoD 3561781..3563622 Escherichia coli 55989 7145936 YP_002404440.1 CDS ygjF NC_011748.1 3563700 3564206 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20412902, 99453007, 6269063, 7567469, 8878487, 9489705; Product type e : enzyme; G/U mismatch-specific DNA glycosylase complement(3563700..3564206) Escherichia coli 55989 7147498 YP_002404441.1 CDS yqjH NC_011748.1 3564460 3565224 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; siderophore interacting protein complement(3564460..3565224) Escherichia coli 55989 7145345 YP_002404442.1 CDS yqjI NC_011748.1 3565501 3566124 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 3565501..3566124 Escherichia coli 55989 7149433 YP_002404443.1 CDS aer NC_011748.1 3566278 3567798 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 9380671, 9643537, 9190831; Product type r : regulator; fused signal transducer for aerotaxis sensory component ; methyl accepting chemotaxis component complement(3566278..3567798) Escherichia coli 55989 7149434 YP_002404444.1 CDS ygjG NC_011748.1 3568189 3569595 D catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate; putrescine--2-oxoglutarate aminotransferase 3568189..3569595 Escherichia coli 55989 7145463 YP_002404445.1 CDS ygjH NC_011748.1 3569637 3569969 R Evidence 2b : Function of strongly homologous gene; PubMedId : 11101501; hypothetical protein complement(3569637..3569969) Escherichia coli 55989 7148904 YP_002404446.1 CDS ebgR NC_011748.1 3570188 3571171 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89128452, 2515108, 3939708; Product type r : regulator; DNA-binding transcriptional repressor EbgR 3570188..3571171 Escherichia coli 55989 7148905 YP_002404447.1 CDS ebgA NC_011748.1 3571355 3574447 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit alpha 3571355..3574447 Escherichia coli 55989 7145969 YP_002404448.1 CDS ebgC NC_011748.1 3574444 3574893 D in Escherichia coli this is the second beta-galactosidase system; cryptic beta-D-galactosidase subunit beta 3574444..3574893 Escherichia coli 55989 7145967 YP_002404449.1 CDS ygjI NC_011748.1 3574956 3576389 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 3574956..3576389 Escherichia coli 55989 7145968 YP_002404450.1 CDS ygjJ NC_011748.1 3576523 3577593 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3576523..3577593 Escherichia coli 55989 7148906 YP_002404451.1 CDS ygjK NC_011748.1 3577610 3579961 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15213393; Product type pe : enzyme; glycosyl hydrolase 3577610..3579961 Escherichia coli 55989 7148907 YP_002404452.1 CDS fadH NC_011748.1 3580287 3582305 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12840019, 89380266; Product type e : enzyme; 2,4-dienoyl-CoA reductase 3580287..3582305 Escherichia coli 55989 7148908 YP_002404453.1 CDS ygjM NC_011748.1 3582350 3582766 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(3582350..3582766) Escherichia coli 55989 7146059 YP_002404454.1 CDS EC55989_3497 NC_011748.1 3582763 3582933 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3582763..3582933) Escherichia coli 55989 7148909 YP_002404455.1 CDS ygjO NC_011748.1 3583037 3584173 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; methyltransferase small domain complement(3583037..3584173) Escherichia coli 55989 7144996 YP_002404456.1 CDS ygjP NC_011748.1 3584258 3584761 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; metal dependent hydrolase 3584258..3584761 Escherichia coli 55989 7148910 YP_002404457.1 CDS ygjQ NC_011748.1 3584838 3585521 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; thioredoxin-like protein 3584838..3585521 Escherichia coli 55989 7148911 YP_002404458.1 CDS ygjR NC_011748.1 3585582 3586586 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; NAD(P)-binding dehydrogenase 3585582..3586586 Escherichia coli 55989 7148912 YP_002404459.1 CDS alx NC_011748.1 3586869 3587834 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 12107143, 2108134; Product type pm : membrane component; inner membrane protein, part of terminus 3586869..3587834 Escherichia coli 55989 7147700 YP_002404460.1 CDS sstT NC_011748.1 3588233 3589477 D involved in the import of serine and threonine coupled with the import of sodium; serine/threonine transporter SstT 3588233..3589477 Escherichia coli 55989 7145489 YP_002404461.1 CDS ygjV NC_011748.1 3589482 3590033 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(3589482..3590033) Escherichia coli 55989 7147718 YP_002404462.1 CDS uxaA NC_011748.1 3590116 3591603 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4570160, 83114543, 3038546; Product type e : enzyme; altronate hydrolase complement(3590116..3591603) Escherichia coli 55989 7148914 YP_002404463.1 CDS uxaC NC_011748.1 3591618 3593030 R catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism; glucuronate isomerase complement(3591618..3593030) Escherichia coli 55989 7147938 YP_002404464.1 CDS exuT NC_011748.1 3593393 3594811 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 83218546, 98190790; Product type t : transporter; hexuronate transporter 3593393..3594811 Escherichia coli 55989 7147940 YP_002404465.1 CDS EC55989_3508 NC_011748.1 3594899 3595987 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3594899..3595987) Escherichia coli 55989 7146045 YP_002404466.1 CDS EC55989_3509 NC_011748.1 3595984 3598686 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3595984..3598686) Escherichia coli 55989 7144997 YP_002404467.1 CDS EC55989_3510 NC_011748.1 3598760 3599260 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; adhesin major subunit pilin complement(3598760..3599260) Escherichia coli 55989 7144998 YP_002404468.1 CDS EC55989_3511 NC_011748.1 3599290 3600006 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial protein complement(3599290..3600006) Escherichia coli 55989 7144999 YP_002404469.1 CDS exuR NC_011748.1 3600302 3601078 D regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.; DNA-binding transcriptional repressor ExuR 3600302..3601078 Escherichia coli 55989 7145000 YP_002404470.1 CDS yqjA NC_011748.1 3601423 3602085 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3601423..3602085 Escherichia coli 55989 7146044 YP_002404471.1 CDS yqjB NC_011748.1 3602089 3602472 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3602089..3602472 Escherichia coli 55989 7149426 YP_002404472.1 CDS yqjC NC_011748.1 3602619 3602987 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3602619..3602987 Escherichia coli 55989 7149427 YP_002404473.1 CDS yqjD NC_011748.1 3603025 3603330 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3603025..3603330 Escherichia coli 55989 7149428 YP_002404474.1 CDS yqjE NC_011748.1 3603333 3603737 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3603333..3603737 Escherichia coli 55989 7149429 YP_002404475.1 CDS yqjK NC_011748.1 3603727 3604026 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3603727..3604026 Escherichia coli 55989 7149430 YP_002404476.1 CDS yqjF NC_011748.1 3604212 3604604 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; quinol oxidase subunit 3604212..3604604 Escherichia coli 55989 7149435 YP_002404477.1 CDS yqjG NC_011748.1 3604674 3605660 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8478329; Product type e : enzyme; S-transferase 3604674..3605660 Escherichia coli 55989 7149431 YP_002404478.1 CDS yhaH NC_011748.1 3605953 3606318 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3605953..3606318 Escherichia coli 55989 7149432 YP_002404479.1 CDS yhaI NC_011748.1 3606560 3606916 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3606560..3606916 Escherichia coli 55989 7148917 YP_002404480.1 CDS yhaJ NC_011748.1 3606967 3607863 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(3606967..3607863) Escherichia coli 55989 7148918 YP_002404481.1 CDS yhaK NC_011748.1 3607968 3608669 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; pirin-related protein 3607968..3608669 Escherichia coli 55989 7148919 YP_002404482.1 CDS yhaL NC_011748.1 3608692 3608856 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3608692..3608856 Escherichia coli 55989 7148920 YP_002404483.1 CDS yhaM NC_011748.1 3608917 3610227 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3608917..3610227) Escherichia coli 55989 7148921 YP_002404484.1 CDS yhaO NC_011748.1 3610255 3611523 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter complement(3610255..3611523) Escherichia coli 55989 7148922 YP_002404485.1 CDS tdcG NC_011748.1 3611861 3613225 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; L-serine dehydratase 3 complement(3611861..3613225) Escherichia coli 55989 7148923 YP_002404486.1 CDS tdcF NC_011748.1 3613297 3613686 R Evidence 2b : Function of strongly homologous gene; PubMedId : 12777779, 9484901; Product type e : enzyme; hypothetical protein complement(3613297..3613686) Escherichia coli 55989 7147769 YP_002404487.1 CDS tdcE NC_011748.1 3613700 3615994 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98143432, 9484901; Product type e : enzyme; pyruvate formate-lyase 4/2-ketobutyrate formate-lyase complement(3613700..3615994) Escherichia coli 55989 7147768 YP_002404488.1 CDS tdcD NC_011748.1 3616028 3617248 R catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism; propionate/acetate kinase complement(3616028..3617248) Escherichia coli 55989 7147767 YP_002404489.1 CDS tdcC NC_011748.1 3617262 3618593 R involved in the import of threonine and serine in combination with the import of a proton; threonine/serine transporter TdcC complement(3617262..3618593) Escherichia coli 55989 7147766 YP_002404490.1 CDS tdcB NC_011748.1 3618615 3619604 R catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic; threonine dehydratase complement(3618615..3619604) Escherichia coli 55989 7147765 YP_002404491.1 CDS tdcA NC_011748.1 3619703 3620641 R regulates the tdcABCDEFG operon which is involved in amino acid degradation; DNA-binding transcriptional activator TdcA complement(3619703..3620641) Escherichia coli 55989 7147764 YP_002404492.1 CDS tdcR NC_011748.1 3620818 3621174 D participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon; DNA-binding transcriptional activator TdcR 3620818..3621174 Escherichia coli 55989 7147763 YP_002404493.1 CDS yhaB NC_011748.1 3621430 3621969 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3621430..3621969 Escherichia coli 55989 7147770 YP_002404494.1 CDS yhaC NC_011748.1 3621991 3623178 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1705543, 2573820, 2660107, 6351058; hypothetical protein 3621991..3623178 Escherichia coli 55989 7148915 YP_002404495.1 CDS EC55989_3540 NC_011748.1 3623516 3624496 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family 3623516..3624496 Escherichia coli 55989 7148916 YP_002404496.1 CDS garK NC_011748.1 3625593 3626819 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 69151449, 9772162; Product type e : enzyme; glycerate kinase complement(3625593..3626819) Escherichia coli 55989 7147454 YP_002404497.1 CDS garR NC_011748.1 3626835 3627725 R catalyzes the reduction of tartronate semialdehyde to glycerate; tartronate semialdehyde reductase complement(3626835..3627725) Escherichia coli 55989 7146259 YP_002404498.1 CDS garL NC_011748.1 3627755 3628525 R cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate; alpha-dehydro-beta-deoxy-D-glucarate aldolase complement(3627755..3628525) Escherichia coli 55989 7146262 YP_002404499.1 CDS garP NC_011748.1 3628541 3629875 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10762278, 9772162; Product type pt : transporter; (D)-galactarate transporter complement(3628541..3629875) Escherichia coli 55989 7146260 YP_002404500.1 CDS garD NC_011748.1 3630249 3631820 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20225875, 66096392, 81027430, 9772162, 10762278, 2407727; Product type e : enzyme; (D)-galactarate dehydrogenase 3630249..3631820 Escherichia coli 55989 7146261 YP_002404501.1 CDS sohA NC_011748.1 3631969 3632304 D SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation; regulator PrlF 3631969..3632304 Escherichia coli 55989 7146258 YP_002404502.1 CDS yhaV NC_011748.1 3632304 3632768 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3632304..3632768 Escherichia coli 55989 7147674 YP_002404503.1 CDS agaR NC_011748.1 3632823 3633632 R transcriptional repressor for the agaZVWA and agaSYBCDI operons; DNA-binding transcriptional regulator AgaR complement(3632823..3633632) Escherichia coli 55989 7148924 YP_002404504.1 CDS kbaZ NC_011748.1 3633881 3635161 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11976750, 20392444, 10931310, 8932697; Product type e : enzyme; tagatose 6-phosphate aldolase 1, kbaZ subunit 3633881..3635161 Escherichia coli 55989 7145470 YP_002404505.1 CDS agaV NC_011748.1 3635184 3635657 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3635184..3635657 Escherichia coli 55989 7146648 YP_002404506.1 CDS EC55989_3552 NC_011748.1 3635668 3636447 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; enzyme IIC component of PTS 3635668..3636447 Escherichia coli 55989 7145472 YP_002404507.1 CDS EC55989_3553 NC_011748.1 3636431 3637315 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; hexose/hexosamine family PTS permease IID component 3636431..3637315 Escherichia coli 55989 7145002 YP_002404508.1 CDS EC55989_3554 NC_011748.1 3637333 3637767 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; phosphotransferase system enzyme subunit (N-acetyl-galactosamine / galactosamine PTS system enzyme IIA component) 3637333..3637767 Escherichia coli 55989 7145003 YP_002404509.1 CDS agaA NC_011748.1 3637743 3638897 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; N-acetylglucosamine-6-phosphate deacetylase (GlcNAc 6-P deacetylase) 3637743..3638897 Escherichia coli 55989 7145004 YP_002404510.1 CDS agaS NC_011748.1 3639247 3640401 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689210, 9697096, 14731281, 8932697; Product type e : enzyme; tagatose-6-phosphate ketose/aldose isomerase 3639247..3640401 Escherichia coli 55989 7145465 YP_002404511.1 CDS kbaY NC_011748.1 3640414 3641274 D catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway; tagatose-bisphosphate aldolase 3640414..3641274 Escherichia coli 55989 7145471 YP_002404512.1 CDS agaB NC_011748.1 3641441 3641917 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIB 3641441..3641917 Escherichia coli 55989 7146647 YP_002404513.1 CDS agaC NC_011748.1 3641956 3642759 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IIC 3641956..3642759 Escherichia coli 55989 7145466 YP_002404514.1 CDS agaD NC_011748.1 3642749 3643540 D catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport; PTS system N-acetylgalactosamine-specific transporter subunit IID 3642749..3643540 Escherichia coli 55989 7145467 YP_002404515.1 CDS agaI NC_011748.1 3643541 3644296 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10931310; Product type e : enzyme; galactosamine-6-phosphate isomerase 3643541..3644296 Escherichia coli 55989 7145468 YP_002404516.1 CDS yraH NC_011748.1 3644696 3645280 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein 3644696..3645280 Escherichia coli 55989 7145469 YP_002404517.1 CDS yraI NC_011748.1 3645360 3646055 D Evidence 2b : Function of strongly homologous gene; PubMedId : 11677609; Product type f : factor; periplasmic pilin chaperone (lpfB-like) 3645360..3646055 Escherichia coli 55989 7149436 YP_002404518.1 CDS yraJ NC_011748.1 3646085 3648601 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; outer membrane protein 3646085..3648601 Escherichia coli 55989 7149437 YP_002404519.1 CDS yraK NC_011748.1 3648612 3649703 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial-like adhesin protein (lpfD-like) 3648612..3649703 Escherichia coli 55989 7149438 YP_002404520.1 CDS yraL NC_011748.1 3649746 3650606 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; methyltransferase complement(3649746..3650606) Escherichia coli 55989 7149439 YP_002404521.1 CDS yraM NC_011748.1 3650670 3652706 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3650670..3652706 Escherichia coli 55989 7149440 YP_002404522.1 CDS yraN NC_011748.1 3652664 3653059 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3652664..3653059 Escherichia coli 55989 7149441 YP_002404523.1 CDS yraO NC_011748.1 3653079 3653669 D Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein; DnaA initiator-associating protein DiaA 3653079..3653669 Escherichia coli 55989 7149442 YP_002404524.1 CDS ecfH NC_011748.1 3653679 3654254 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11274153; hypothetical protein 3653679..3654254 Escherichia coli 55989 7149443 YP_002404525.1 CDS yraQ NC_011748.1 3654368 3655408 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; permease complement(3654368..3655408) Escherichia coli 55989 7145970 YP_002404526.1 CDS yraR NC_011748.1 3655481 3656116 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; nucleoside-diphosphate-sugar epimerase complement(3655481..3656116) Escherichia coli 55989 7149444 YP_002404527.1 CDS yhbO NC_011748.1 3656244 3656762 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; intracellular protease 3656244..3656762 Escherichia coli 55989 7149445 YP_002404528.1 CDS yhbP NC_011748.1 3656742 3657185 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3656742..3657185) Escherichia coli 55989 7148929 YP_002404529.1 CDS yhbQ NC_011748.1 3657236 3657538 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; GIY-YIG nuclease superfamily protein 3657236..3657538 Escherichia coli 55989 7148930 YP_002404530.1 CDS yhbS NC_011748.1 3657525 3658028 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acyltransferase with acyl-CoA N-acyltransferase domain complement(3657525..3658028) Escherichia coli 55989 7148931 YP_002404531.1 CDS yhbT NC_011748.1 3658022 3658546 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; lipid carrier protein complement(3658022..3658546) Escherichia coli 55989 7148932 YP_002404532.1 CDS yhbU NC_011748.1 3658755 3659750 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; peptidase (collagenase-like) 3658755..3659750 Escherichia coli 55989 7148933 YP_002404533.1 CDS yhbV NC_011748.1 3659759 3660637 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10206698; Product type e : enzyme; protease 3659759..3660637 Escherichia coli 55989 7148934 YP_002404534.1 CDS yhbW NC_011748.1 3660843 3661850 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 3660843..3661850 Escherichia coli 55989 7148935 YP_002404535.1 CDS mtr NC_011748.1 3661968 3663212 R tryptophan transporter of high affinity; tryptophan permease complement(3661968..3663212) Escherichia coli 55989 7148936 YP_002404536.1 CDS deaD NC_011748.1 3663366 3665255 R participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division; ATP-dependent RNA helicase DeaD complement(3663366..3665255) Escherichia coli 55989 7146917 YP_002404537.1 CDS nlpI NC_011748.1 3665435 3666319 R lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing; lipoprotein NlpI complement(3665435..3666319) Escherichia coli 55989 7145875 YP_002404538.1 CDS pnp NC_011748.1 3666428 3668632 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87083499, 91198209, 99234021, 99340204, 2432069, 3005122, 6382163, 9008164, 9298646; Product type e : enzyme; polynucleotide phosphorylase complement(3666428..3668632) Escherichia coli 55989 7147011 YP_002404539.1 CDS rpsO NC_011748.1 3668810 3669079 R primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence; 30S ribosomal protein S15 complement(3668810..3669079) Escherichia coli 55989 7147701 YP_002404540.1 CDS truB NC_011748.1 3669228 3670172 R catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs; tRNA pseudouridine synthase B complement(3669228..3670172) Escherichia coli 55989 7147519 YP_002404541.1 CDS rbfA NC_011748.1 3670172 3670573 R associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock; ribosome-binding factor A complement(3670172..3670573) Escherichia coli 55989 7147859 YP_002404542.1 CDS infB NC_011748.1 3670737 3673409 R Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex; translation initiation factor IF-2 complement(3670737..3673409) Escherichia coli 55989 7147339 YP_002404543.1 CDS nusA NC_011748.1 3673434 3674921 R modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination; transcription elongation factor NusA complement(3673434..3674921) Escherichia coli 55989 7146566 YP_002404544.1 CDS yhbC NC_011748.1 3674949 3675401 R in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins; hypothetical protein complement(3674949..3675401) Escherichia coli 55989 7147058 YP_002404545.1 CDS argG NC_011748.1 3676032 3677375 D catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis; argininosuccinate synthase 3676032..3677375 Escherichia coli 55989 7145378 YP_002404546.1 CDS yhbX NC_011748.1 3677383 3679008 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase, inner membrane complement(3677383..3679008) Escherichia coli 55989 7145529 YP_002404547.1 CDS secG NC_011748.1 3679566 3679898 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20194819, 21125563, 9020118, 94074540, 9564033, 9644254, 9829959, 99298179, 7556084, 8034620, 8045257, 8244950, 8253068; Product type t : transporter; preprotein translocase subunit SecG complement(3679566..3679898) Escherichia coli 55989 7145377 YP_002404548.1 CDS glmM NC_011748.1 3680126 3681463 R catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; phosphoglucosamine mutase complement(3680126..3681463) Escherichia coli 55989 7147625 YP_002404549.1 CDS folP NC_011748.1 3681456 3682304 R catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate; dihydropteroate synthase complement(3681456..3682304) Escherichia coli 55989 7146299 YP_002404550.1 CDS hflB NC_011748.1 3682394 3684328 R inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins; ATP-dependent metalloprotease complement(3682394..3684328) Escherichia coli 55989 7146175 YP_002404551.1 CDS rrmJ NC_011748.1 3684428 3685057 R Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit; 23S rRNA methyltransferase complement(3684428..3685057) Escherichia coli 55989 7146213 YP_002404552.1 CDS yhbY NC_011748.1 3685183 3685476 D RNA binding protein found associated to pre-50S subunit of the ribosome; role in ribosome assembly; necessary for optimal growth but not cell viability; RNA-binding protein YhbY 3685183..3685476 Escherichia coli 55989 7147528 YP_002404553.1 CDS greA NC_011748.1 3685632 3686108 R necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreA complement(3685632..3686108) Escherichia coli 55989 7148938 YP_002404554.1 CDS dacB NC_011748.1 3686356 3687789 D penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains; D-alanyl-D-alanine carboxypeptidase 3686356..3687789 Escherichia coli 55989 7146365 YP_002404555.1 CDS obgE NC_011748.1 3687829 3689001 R essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication; GTPase ObgE complement(3687829..3689001) Escherichia coli 55989 7145842 YP_002404556.1 CDS yhbE NC_011748.1 3689017 3689982 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(3689017..3689982) Escherichia coli 55989 7147063 YP_002404557.1 CDS rpmA NC_011748.1 3690109 3690366 R involved in the peptidyltransferase reaction during translation; 50S ribosomal protein L27 complement(3690109..3690366) Escherichia coli 55989 7148926 YP_002404558.1 CDS rplU NC_011748.1 3690387 3690698 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91088242, 94146411, 10094780, 387076, 8312607; Product type s : structure; 50S ribosomal protein L21 complement(3690387..3690698) Escherichia coli 55989 7147486 YP_002404559.1 CDS ispB NC_011748.1 3690957 3691928 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94311902, 97284515, 2670911, 8037730, 8312607; Product type e : enzyme; octaprenyl diphosphate synthase 3690957..3691928 Escherichia coli 55989 7147481 YP_002404560.1 CDS sfsB NC_011748.1 3692156 3692434 D activator of maltose metabolism genes; DNA-binding transcriptional regulator Nlp 3692156..3692434 Escherichia coli 55989 7146626 YP_002404561.1 CDS murA NC_011748.1 3692482 3693741 R adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active; UDP-N-acetylglucosamine 1-carboxyvinyltransferase complement(3692482..3693741) Escherichia coli 55989 7147646 YP_002404562.1 CDS yrbA NC_011748.1 3693796 3694050 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(3693796..3694050) Escherichia coli 55989 7146921 YP_002404563.1 CDS yrbB NC_011748.1 3694210 3694503 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3694210..3694503) Escherichia coli 55989 7149446 YP_002404564.1 CDS yrbC NC_011748.1 3694503 3695138 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene transporter subunit: membrane component of ABC superfamily complement(3694503..3695138) Escherichia coli 55989 7149447 YP_002404565.1 CDS yrbD NC_011748.1 3695157 3695708 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene transporter subunit: membrane component of ABC superfamily complement(3695157..3695708) Escherichia coli 55989 7149448 YP_002404566.1 CDS yrbE NC_011748.1 3695713 3696495 R Evidence 2b : Function of strongly homologous gene; PubMedId : 9658016; Product type t : transporter; toluene transporter subunit: membrane component of ABC superfamily complement(3695713..3696495) Escherichia coli 55989 7149449 YP_002404567.1 CDS yrbF NC_011748.1 3696503 3697312 R ATP-binding subunit of a ABC toluene efflux transporter; ABC transporter ATP-binding protein complement(3696503..3697312) Escherichia coli 55989 7149450 YP_002404568.1 CDS yrbG NC_011748.1 3697522 3698499 D YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers; calcium/sodium:proton antiporter 3697522..3698499 Escherichia coli 55989 7149451 YP_002404569.1 CDS kdsD NC_011748.1 3698513 3699499 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12805358; Product type e : enzyme; D-arabinose 5-phosphate isomerase 3698513..3699499 Escherichia coli 55989 7149452 YP_002404570.1 CDS kdsC NC_011748.1 3699520 3700086 D forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase 3699520..3700086 Escherichia coli 55989 7146662 YP_002404571.1 CDS yrbK NC_011748.1 3700083 3700658 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3700083..3700658 Escherichia coli 55989 7146661 YP_002404572.1 CDS lptA NC_011748.1 3700627 3701184 D LptA; periplasmic binding protein part of a ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system; lipopolysaccharide transport periplasmic protein LptA 3700627..3701184 Escherichia coli 55989 7149453 YP_002404573.1 CDS lptB NC_011748.1 3701191 3701916 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7876255, 9298646, 17056748; Product type pt : transporter; ABC transporter ATP-binding protein 3701191..3701916 Escherichia coli 55989 7146733 YP_002404574.1 CDS rpoN NC_011748.1 3701964 3703397 D sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen; RNA polymerase factor sigma-54 3701964..3703397 Escherichia coli 55989 7146734 YP_002404575.1 CDS yhbH NC_011748.1 3703420 3703707 D YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing; sigma(54) modulation protein 3703420..3703707 Escherichia coli 55989 7147501 YP_002404576.1 CDS ptsN NC_011748.1 3703825 3704316 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88212176, 90136533, 90274974, 95020584, 95181483, 7876255, 8025669, 8444818, 9636714; Product type t : transporter; PTS system transporter subunit IIA-like nitrogen-regulatory protein PtsN 3703825..3704316 Escherichia coli 55989 7148927 YP_002404577.1 CDS yhbJ NC_011748.1 3704362 3705216 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3704362..3705216 Escherichia coli 55989 7147290 YP_002404578.1 CDS npr NC_011748.1 3705213 3705485 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10473571, 95181483, 7876255, 8025669; Product type t : transporter; phosphohistidinoprotein-hexose phosphotransferase component of N-regulated PTS system (Npr) 3705213..3705485 Escherichia coli 55989 7148928 YP_002404579.1 CDS yrbL NC_011748.1 3705698 3706330 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 89083480; hypothetical protein 3705698..3706330 Escherichia coli 55989 7147017 YP_002404580.1 CDS mtgA NC_011748.1 3706327 3707055 R glycosyltransferase; polymerizes glycan strands in the peptidoglycan; monofunctional biosynthetic peptidoglycan transglycosylase complement(3706327..3707055) Escherichia coli 55989 7149454 YP_002404581.1 CDS elbB NC_011748.1 3707052 3707705 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92246944, 98269038, 1575737, 9603997; Product type pe : enzyme; isoprenoid biosynthesis protein with amidotransferase-like domain complement(3707052..3707705) Escherichia coli 55989 7146913 YP_002404582.1 CDS arcB NC_011748.1 3707935 3710271 R sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA; aerobic respiration control sensor protein ArcB complement(3707935..3710271) Escherichia coli 55989 7147591 YP_002404583.1 CDS yhcC NC_011748.1 3710367 3711296 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; Fe-S oxidoreductase complement(3710367..3711296) Escherichia coli 55989 7145523 YP_002404584.1 CDS gltB NC_011748.1 3711878 3716431 D catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate; glutamate synthase subunit alpha 3711878..3716431 Escherichia coli 55989 7148940 YP_002404585.1 CDS gltD NC_011748.1 3716444 3717862 D glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate; glutamate synthase subunit beta 3716444..3717862 Escherichia coli 55989 7146328 YP_002404586.1 CDS EC55989_3633 NC_011748.1 3718506 3718847 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3718506..3718847 Escherichia coli 55989 7148941 YP_002404587.1 CDS yhcH NC_011748.1 3718923 3719387 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3718923..3719387) Escherichia coli 55989 7145005 YP_002404588.1 CDS nanK NC_011748.1 3719384 3720259 R catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein; N-acetylmannosamine kinase complement(3719384..3720259) Escherichia coli 55989 7148942 YP_002404589.1 CDS nanE NC_011748.1 3720256 3720945 R Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase complement(3720256..3720945) Escherichia coli 55989 7146957 YP_002404590.1 CDS nanT NC_011748.1 3720993 3722483 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96011396, 9864311, 7592358; Product type t : transporter; sialic acid transporter complement(3720993..3722483) Escherichia coli 55989 7146955 YP_002404591.1 CDS nanA NC_011748.1 3722592 3723485 R catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid; N-acetylneuraminate lyase complement(3722592..3723485) Escherichia coli 55989 7146959 YP_002404592.1 CDS nanR NC_011748.1 3723607 3724398 R Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization; transcriptional regulator NanR complement(3723607..3724398) Escherichia coli 55989 7146954 YP_002404593.1 CDS dcuD NC_011748.1 3724778 3726145 D YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic; cryptic C4-dicarboxylate transporter DcuD 3724778..3726145 Escherichia coli 55989 7146958 YP_002404594.1 CDS sspB NC_011748.1 3726188 3726685 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12445774, 94293773, 1721886, 3029697, 8022275; Product type f : factor; ClpXP protease specificity-enhancing factor complement(3726188..3726685) Escherichia coli 55989 7145863 YP_002404595.1 CDS sspA NC_011748.1 3726691 3727329 R transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation; stringent starvation protein A complement(3726691..3727329) Escherichia coli 55989 7147715 YP_002404596.1 CDS rpsI NC_011748.1 3727724 3728116 R forms a direct contact with the tRNA during translation; 30S ribosomal protein S9 complement(3727724..3728116) Escherichia coli 55989 7147714 YP_002404597.1 CDS rplM NC_011748.1 3728132 3728560 R in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit; 50S ribosomal protein L13 complement(3728132..3728560) Escherichia coli 55989 7147513 YP_002404598.1 CDS yhcM NC_011748.1 3728779 3729906 R Evidence 4 : Homologs of previously reported genes of unknown function; nucleoside triphosphate hydrolase domain complement(3728779..3729906) Escherichia coli 55989 7147473 YP_002404599.1 CDS yhcB NC_011748.1 3730100 3730498 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16079137; Product type pe : enzyme; cytochrome d ubiquinol oxidase subunit III 3730100..3730498 Escherichia coli 55989 7148943 YP_002404600.1 CDS degQ NC_011748.1 3730652 3732019 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8830688, 96165272, 8576051, 8576052, 9740056; Product type e : enzyme; serine endoprotease 3730652..3732019 Escherichia coli 55989 7148939 YP_002404601.1 CDS degS NC_011748.1 3732109 3733176 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15137941, 15225661, 21352996, 96165272, 99431977, 3322223, 8576051; Product type e : enzyme; serine endoprotease 3732109..3733176 Escherichia coli 55989 7145880 YP_002404602.1 CDS mdh NC_011748.1 3733239 3734177 R oxidizes malate to oxaloacetate; malate dehydrogenase complement(3733239..3734177) Escherichia coli 55989 7145881 YP_002404603.1 CDS argR NC_011748.1 3734612 3735082 D regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes; arginine repressor ArgR 3734612..3735082 Escherichia coli 55989 7146794 YP_002404604.1 CDS yhcN NC_011748.1 3735447 3735710 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3735447..3735710 Escherichia coli 55989 7145535 YP_002404605.1 CDS yhcO NC_011748.1 3735766 3736038 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; barnase inhibitor complement(3735766..3736038) Escherichia coli 55989 7148944 YP_002404606.1 CDS aaeB NC_011748.1 3736130 3738097 R with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeB complement(3736130..3738097) Escherichia coli 55989 7148945 YP_002404607.1 CDS aaeA NC_011748.1 3738103 3739035 R with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate; p-hydroxybenzoic acid efflux subunit AaeA complement(3738103..3739035) Escherichia coli 55989 7145413 YP_002404608.1 CDS aaeX NC_011748.1 3739043 3739246 R membrane protein AaeX; the gene is a member of the aaeXAB operon; hypothetical protein complement(3739043..3739246) Escherichia coli 55989 7145412 YP_002404609.1 CDS aaeR NC_011748.1 3739429 3740358 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15489430; Product type r : regulator; DNA-binding transcriptional regulator 3739429..3740358 Escherichia coli 55989 7145415 YP_002404610.1 CDS tldD NC_011748.1 3740486 3741931 R responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA; protease TldD complement(3740486..3741931) Escherichia coli 55989 7145414 YP_002404611.1 CDS yhdP NC_011748.1 3742087 3745887 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10960106; Product type pm : membrane component; hypothetical protein complement(3742087..3745887) Escherichia coli 55989 7147806 YP_002404612.1 CDS rng NC_011748.1 3745955 3747424 R involved in the processing of the 5'end of 16S rRNA; ribonuclease G complement(3745955..3747424) Escherichia coli 55989 7148951 YP_002404613.1 CDS yhdE NC_011748.1 3747414 3748007 R Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell; Maf-like protein complement(3747414..3748007) Escherichia coli 55989 7147449 YP_002404614.1 CDS mreD NC_011748.1 3748016 3748504 R part of cell wall structural complex MreBCD; transmembrane component; rod shape-determining protein MreD complement(3748016..3748504) Escherichia coli 55989 7148946 YP_002404615.1 CDS EC55989_3662 NC_011748.1 3748488 3748619 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3748488..3748619) Escherichia coli 55989 7146904 YP_002404616.1 CDS mreC NC_011748.1 3748504 3749607 R in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall; rod shape-determining protein MreC complement(3748504..3749607) Escherichia coli 55989 7145006 YP_002404617.1 CDS mreB NC_011748.1 3749673 3750716 R functions in MreBCD complex in some organisms; rod shape-determining protein MreB complement(3749673..3750716) Escherichia coli 55989 7146903 YP_002404618.1 CDS EC55989_3665 NC_011748.1 3750824 3751012 D Evidence 6 : Doubtful CDS; hypothetical protein 3750824..3751012 Escherichia coli 55989 7146902 YP_002404619.1 CDS csrD NC_011748.1 3751021 3752961 R regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules; regulatory protein CsrD complement(3751021..3752961) Escherichia coli 55989 7145007 YP_002404620.1 CDS yhdH NC_011748.1 3753113 3754087 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase, Zn-dependent and NAD(P)-binding 3753113..3754087 Escherichia coli 55989 7145786 YP_002404621.1 CDS accB NC_011748.1 3755065 3755535 D composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxyl carrier protein subunit 3755065..3755535 Escherichia coli 55989 7148947 YP_002404622.1 CDS accC NC_011748.1 3755546 3756895 D an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism; acetyl-CoA carboxylase biotin carboxylase subunit 3755546..3756895 Escherichia coli 55989 7145429 YP_002404623.1 CDS yhdT NC_011748.1 3757004 3757246 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 3757004..3757246 Escherichia coli 55989 7145430 YP_002404624.1 CDS panF NC_011748.1 3757236 3758687 D mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase; sodium/panthothenate symporter 3757236..3758687 Escherichia coli 55989 7148952 YP_002404625.1 CDS prmA NC_011748.1 3758699 3759580 D methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype; 50S ribosomal protein L11 methyltransferase 3758699..3759580 Escherichia coli 55989 7147114 YP_002404626.1 CDS dusB NC_011748.1 3759909 3760874 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566, 1459953, 1547773, 2835774, 2837762, 8226664; Product type e : enzyme; tRNA-dihydrouridine synthase B 3759909..3760874 Escherichia coli 55989 7147249 YP_002404627.1 CDS fis NC_011748.1 3760900 3761196 D Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription; DNA-binding protein Fis 3760900..3761196 Escherichia coli 55989 7145960 YP_002404628.1 CDS yhdJ NC_011748.1 3761282 3762166 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15028690, 9073062; Product type e : enzyme; methyltransferase 3761282..3762166 Escherichia coli 55989 7146113 YP_002404629.1 CDS yhdU NC_011748.1 3762250 3762429 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 3762250..3762429 Escherichia coli 55989 7148948 YP_002404630.1 CDS envR NC_011748.1 3762432 3763094 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8203018, 11257026, 8407802, 1720861; Product type r : regulator; DNA-binding transcriptional regulator EnvR complement(3762432..3763094) Escherichia coli 55989 7148953 YP_002404631.1 CDS acrE NC_011748.1 3763493 3764650 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012493, 1720861; Product type lp : lipoprotein; hypothetical protein 3763493..3764650 Escherichia coli 55989 7146006 YP_002404632.1 CDS acrF NC_011748.1 3764662 3767766 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94262163, 99449638, 1720861, 8407802; Product type t : transporter; multidrug efflux system protein 3764662..3767766 Escherichia coli 55989 7145447 YP_002404633.1 CDS yhdV NC_011748.1 3768019 3768240 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; outer membrane protein 3768019..3768240 Escherichia coli 55989 7145448 YP_002404634.1 CDS EC55989_3682 NC_011748.1 3768466 3768642 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3768466..3768642 Escherichia coli 55989 7148954 YP_002404635.1 CDS aapJ NC_011748.1 3768779 3769696 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid transporter subunit ; periplasmic-binding component of ABC superfamily 3768779..3769696 Escherichia coli 55989 7145008 YP_002404636.1 CDS aapQ NC_011748.1 3769764 3770945 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid transporter subunit ; membrane component of ABC superfamily 3769764..3770945 Escherichia coli 55989 7145416 YP_002404637.1 CDS aapM NC_011748.1 3770955 3772058 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8898392; Product type t : transporter; amino-acid transporter subunit ; membrane component of ABC superfamily 3770955..3772058 Escherichia coli 55989 7145419 YP_002404638.1 CDS aapP NC_011748.1 3772066 3772824 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8809753, 8898392; Product type t : transporter; amino-acid ABC transporter ATP-binding protein 3772066..3772824 Escherichia coli 55989 7145417 YP_002404639.1 CDS yrdA NC_011748.1 3778874 3779428 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3778874..3779428 Escherichia coli 55989 7144632 YP_002404640.1 CDS yrdB NC_011748.1 3779404 3779661 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3779404..3779661) Escherichia coli 55989 7149455 YP_002404641.1 CDS aroE NC_011748.1 3779658 3780476 R AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate; shikimate 5-dehydrogenase complement(3779658..3780476) Escherichia coli 55989 7149456 YP_002404642.1 CDS yrdC NC_011748.1 3780481 3781053 R RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA; ribosome maturation factor complement(3780481..3781053) Escherichia coli 55989 7145543 YP_002404643.1 CDS yrdD NC_011748.1 3781058 3781600 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; DNA topoisomerase complement(3781058..3781600) Escherichia coli 55989 7149457 YP_002404644.1 CDS smg NC_011748.1 3781629 3782102 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8432722; hypothetical protein complement(3781629..3782102) Escherichia coli 55989 7149458 YP_002404645.1 CDS smf NC_011748.1 3782074 3783198 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8112305, 8432722; DNA protecting protein DprA complement(3782074..3783198) Escherichia coli 55989 7147667 YP_002404646.1 CDS def NC_011748.1 3783328 3783837 D cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+); peptide deformylase 3783328..3783837 Escherichia coli 55989 7147666 YP_002404647.1 CDS fmt NC_011748.1 3783852 3784799 D modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth; methionyl-tRNA formyltransferase 3783852..3784799 Escherichia coli 55989 7145878 YP_002404648.1 CDS rsmB NC_011748.1 3784845 3786134 D catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase; 16S rRNA methyltransferase GidB 3784845..3786134 Escherichia coli 55989 7146164 YP_002404649.1 CDS trkA NC_011748.1 3786156 3787532 D involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain; potassium transporter peripheral membrane protein 3786156..3787532 Escherichia coli 55989 7147535 YP_002404650.1 CDS mscL NC_011748.1 3787662 3788072 D forms homopentamer; channel that opens in response to pressure or hypoosmotic shock; large-conductance mechanosensitive channel 3787662..3788072 Escherichia coli 55989 7147841 YP_002404651.1 CDS yhdL NC_011748.1 3788069 3788287 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3788069..3788287) Escherichia coli 55989 7146908 YP_002404652.1 CDS zntR NC_011748.1 3788343 3788768 R mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators; zinc-responsive transcriptional regulator complement(3788343..3788768) Escherichia coli 55989 7148949 YP_002404653.1 CDS yhdN NC_011748.1 3788779 3789147 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3788779..3789147) Escherichia coli 55989 7149491 YP_002404654.1 CDS rplQ NC_011748.1 3789254 3789637 R is a component of the macrolide binding site in the peptidyl transferase center; 50S ribosomal protein L17 complement(3789254..3789637) Escherichia coli 55989 7148950 YP_002404655.1 CDS rpoA NC_011748.1 3789678 3790667 R catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme; DNA-directed RNA polymerase subunit alpha complement(3789678..3790667) Escherichia coli 55989 7147477 YP_002404656.1 CDS rpsD NC_011748.1 3790693 3791313 R primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination; 30S ribosomal protein S4 complement(3790693..3791313) Escherichia coli 55989 7147495 YP_002404657.1 CDS rpsK NC_011748.1 3791347 3791736 R located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3; 30S ribosomal protein S11 complement(3791347..3791736) Escherichia coli 55989 7147508 YP_002404658.1 CDS rpsM NC_011748.1 3791753 3792109 R located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA; 30S ribosomal protein S13 complement(3791753..3792109) Escherichia coli 55989 7147515 YP_002404659.1 CDS secY NC_011748.1 3792404 3793735 R forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase; preprotein translocase subunit SecY complement(3792404..3793735) Escherichia coli 55989 7145313 YP_002404660.1 CDS rplO NC_011748.1 3793743 3794177 R late assembly protein; 50S ribosomal protein L15 complement(3793743..3794177) Escherichia coli 55989 7147627 YP_002404661.1 CDS rpmD NC_011748.1 3794181 3794360 R L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7; 50S ribosomal protein L30 complement(3794181..3794360) Escherichia coli 55989 7147475 YP_002404662.1 CDS rpsE NC_011748.1 3794364 3794867 R located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance; 30S ribosomal protein S5 complement(3794364..3794867) Escherichia coli 55989 7147489 YP_002404663.1 CDS rplR NC_011748.1 3794882 3795235 R binds 5S rRNA along with protein L5 and L25; 50S ribosomal protein L18 complement(3794882..3795235) Escherichia coli 55989 7147509 YP_002404664.1 CDS rplF NC_011748.1 3795245 3795778 R ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance; 50S ribosomal protein L6 complement(3795245..3795778) Escherichia coli 55989 7147478 YP_002404665.1 CDS rpsH NC_011748.1 3795791 3796183 R binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit; 30S ribosomal protein S8 complement(3795791..3796183) Escherichia coli 55989 7147468 YP_002404666.1 CDS rpsN NC_011748.1 3796217 3796522 R located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif; 30S ribosomal protein S14 complement(3796217..3796522) Escherichia coli 55989 7147512 YP_002404667.1 CDS rplE NC_011748.1 3796537 3797076 R part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13; 50S ribosomal protein L5 complement(3796537..3797076) Escherichia coli 55989 7147518 YP_002404668.1 CDS rplX NC_011748.1 3797091 3797405 R assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel; 50S ribosomal protein L24 complement(3797091..3797405) Escherichia coli 55989 7147467 YP_002404669.1 CDS rplN NC_011748.1 3797416 3797787 R binds to the 23S rRNA between the centers for peptidyl transferase and GTPase; 50S ribosomal protein L14 complement(3797416..3797787) Escherichia coli 55989 7147484 YP_002404670.1 CDS rpsQ NC_011748.1 3797952 3798206 R primary binding protein; helps mediate assembly; involved in translation fidelity; 30S ribosomal protein S17 complement(3797952..3798206) Escherichia coli 55989 7147474 YP_002404671.1 CDS rpmC NC_011748.1 3798206 3798397 R one of the stabilizing components for the large ribosomal subunit; 50S ribosomal protein L29 complement(3798206..3798397) Escherichia coli 55989 7147521 YP_002404672.1 CDS rplP NC_011748.1 3798397 3798807 R located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e; 50S ribosomal protein L16 complement(3798397..3798807) Escherichia coli 55989 7147488 YP_002404673.1 CDS rpsC NC_011748.1 3798820 3799521 R forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation; 30S ribosomal protein S3 complement(3798820..3799521) Escherichia coli 55989 7147476 YP_002404674.1 CDS rplV NC_011748.1 3799539 3799871 R binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center; 50S ribosomal protein L22 complement(3799539..3799871) Escherichia coli 55989 7147507 YP_002404675.1 CDS rpsS NC_011748.1 3799886 3800164 R protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA; 30S ribosomal protein S19 complement(3799886..3800164) Escherichia coli 55989 7147482 YP_002404676.1 CDS rplB NC_011748.1 3800181 3801002 R one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation; 50S ribosomal protein L2 complement(3800181..3801002) Escherichia coli 55989 7147523 YP_002404677.1 CDS rplW NC_011748.1 3801020 3801322 R binds third domain of 23S rRNA and protein L29; part of exit tunnel; 50S ribosomal protein L23 complement(3801020..3801322) Escherichia coli 55989 7147464 YP_002404678.1 CDS rplD NC_011748.1 3801319 3801924 R L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA; 50S ribosomal protein L4 complement(3801319..3801924) Escherichia coli 55989 7147483 YP_002404679.1 CDS rplC NC_011748.1 3801935 3802564 R binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin; 50S ribosomal protein L3 complement(3801935..3802564) Escherichia coli 55989 7147466 YP_002404680.1 CDS rpsJ NC_011748.1 3802597 3802908 R NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex; 30S ribosomal protein S10 complement(3802597..3802908) Escherichia coli 55989 7147465 YP_002404681.1 CDS EC55989_3738 NC_011748.1 3803037 3803198 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3803037..3803198) Escherichia coli 55989 7147514 YP_002404682.1 CDS EC55989_3739 NC_011748.1 3803287 3803754 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; bifunctional prepilin peptidase HopD: leader peptidase; methyl transferase (General Secretory Pathway) 3803287..3803754 Escherichia coli 55989 7145009 YP_002404683.1 CDS bfr NC_011748.1 3803751 3804227 R iron storage protein; bacterioferritin complement(3803751..3804227) Escherichia coli 55989 7145010 YP_002404684.1 CDS bfd NC_011748.1 3804300 3804494 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8954950, 9889981, 2661540, 8639572; Product type c : carrier; bacterioferritin-associated ferredoxin complement(3804300..3804494) Escherichia coli 55989 7145615 YP_002404685.1 CDS tufA NC_011748.1 3804677 3805861 R EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu complement(3804677..3805861) Escherichia coli 55989 7145614 YP_002404686.1 CDS fusA NC_011748.1 3805932 3808046 R EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene; elongation factor G complement(3805932..3808046) Escherichia coli 55989 7147872 YP_002404687.1 CDS rpsG NC_011748.1 3808143 3808613 R binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit; 30S ribosomal protein S7 complement(3808143..3808613) Escherichia coli 55989 7146234 YP_002404688.1 CDS rpsL NC_011748.1 3808710 3809084 R interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance; 30S ribosomal protein S12 complement(3808710..3809084) Escherichia coli 55989 7147511 YP_002404689.1 CDS tusB NC_011748.1 3809210 3809497 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusB complement(3809210..3809497) Escherichia coli 55989 7147516 YP_002404690.1 CDS tusC NC_011748.1 3809505 3809864 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur relay protein TusC complement(3809505..3809864) Escherichia coli 55989 7147876 YP_002404691.1 CDS tusD NC_011748.1 3809864 3810250 R in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs; sulfur transfer complex subunit TusD complement(3809864..3810250) Escherichia coli 55989 7147877 YP_002404692.1 CDS yheO NC_011748.1 3810250 3810972 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(3810250..3810972) Escherichia coli 55989 7147878 YP_002404693.1 CDS fkpA NC_011748.1 3811139 3811951 R rotamase; FKBP-type peptidylprolyl isomerase complement(3811139..3811951) Escherichia coli 55989 7148955 YP_002404694.1 CDS slyX NC_011748.1 3812172 3812390 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3812172..3812390 Escherichia coli 55989 7146120 YP_002404695.1 CDS slyD NC_011748.1 3812439 3813029 R rotamase; FKBP-type peptidylprolyl isomerase complement(3812439..3813029) Escherichia coli 55989 7147665 YP_002404696.1 CDS yheV NC_011748.1 3813124 3813324 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3813124..3813324) Escherichia coli 55989 7147664 YP_002404697.1 CDS kefB NC_011748.1 3813334 3815139 R involved in potassium efflux; glutathione-regulated potassium-efflux system protein KefB complement(3813334..3815139) Escherichia coli 55989 7148959 YP_002404698.1 CDS kefG NC_011748.1 3815139 3815693 R required for KefB activity; glutathione-regulated potassium-efflux system ancillary protein KefG complement(3815139..3815693) Escherichia coli 55989 7146667 YP_002404699.1 CDS yheS NC_011748.1 3815821 3817734 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; ABC transporter ATP-binding protein 3815821..3817734 Escherichia coli 55989 7146670 YP_002404700.1 CDS yheT NC_011748.1 3817734 3818756 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9889164; Product type pe : enzyme; hydrolase 3817734..3818756 Escherichia coli 55989 7148956 YP_002404701.1 CDS yheU NC_011748.1 3818750 3818968 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3818750..3818968 Escherichia coli 55989 7148957 YP_002404702.1 CDS prkB NC_011748.1 3819022 3819891 D Evidence 2b : Function of strongly homologous gene; PubMedId : 2559876; Product type e : enzyme; phosphoribulokinase 3819022..3819891 Escherichia coli 55989 7148958 YP_002404703.1 CDS yhfA NC_011748.1 3819946 3820350 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3819946..3820350) Escherichia coli 55989 7147247 YP_002404704.1 CDS EC55989_3762 NC_011748.1 3820430 3820645 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3820430..3820645 Escherichia coli 55989 7145761 YP_002404705.1 CDS crp NC_011748.1 3820652 3821284 D complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons; cAMP-regulatory protein 3820652..3821284 Escherichia coli 55989 7145011 YP_002404706.1 CDS yhfK NC_011748.1 3821323 3823425 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3821323..3823425 Escherichia coli 55989 7145760 YP_002404707.1 CDS argD NC_011748.1 3823492 3824712 R DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate; bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein complement(3823492..3824712) Escherichia coli 55989 7148962 YP_002404708.1 CDS pabA NC_011748.1 3824798 3825361 R aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity; para-aminobenzoate synthase component II complement(3824798..3825361) Escherichia coli 55989 7145527 YP_002404709.1 CDS fic NC_011748.1 3825393 3825995 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92021789, 94095125, 2007139, 2403545, 2546924, 7549107; Product type cp : cell process; cell filamentation protein Fic complement(3825393..3825995) Escherichia coli 55989 7147106 YP_002404710.1 CDS yhfG NC_011748.1 3825985 3826152 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3825985..3826152) Escherichia coli 55989 7146107 YP_002404711.1 CDS ppiA NC_011748.1 3826257 3826829 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90272647, 91175755, 1606970, 2001362, 2007139, 2190212, 2403545, 2546924, 8130188, 8180197; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase A complement(3826257..3826829) Escherichia coli 55989 7148961 YP_002404712.1 CDS tsgA NC_011748.1 3827100 3828281 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20509826; Product type pt : transporter; hypothetical protein 3827100..3828281 Escherichia coli 55989 7147228 YP_002404713.1 CDS nirB NC_011748.1 3828543 3831086 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93062014, 2200672, 2445993, 2543955; Product type e : enzyme; nitrite reductase, large subunit, NAD(P) H-binding 3828543..3831086 Escherichia coli 55989 7147866 YP_002404714.1 CDS nirD NC_011748.1 3831083 3831409 D involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations; nitrite reductase small subunit 3831083..3831409 Escherichia coli 55989 7147003 YP_002404715.1 CDS nirC NC_011748.1 3831536 3832342 D member of the FNT family of formate and nitrite transporters; nitrite transporter NirC 3831536..3832342 Escherichia coli 55989 7147005 YP_002404716.1 CDS cysG NC_011748.1 3832361 3833734 D multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin; siroheme synthase 3832361..3833734 Escherichia coli 55989 7147004 YP_002404717.1 CDS yhfL NC_011748.1 3833981 3834148 D Evidence 4 : Homologs of previously reported genes of unknown function; secreted peptide 3833981..3834148 Escherichia coli 55989 7145825 YP_002404718.1 CDS frlA NC_011748.1 3834443 3835780 D inner membrane protein possibly involved in fructoselysine transport; member of the flr operon; fructoselysine transporter 3834443..3835780 Escherichia coli 55989 7148963 YP_002404719.1 CDS frlB NC_011748.1 3835801 3836823 D catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine; fructoselysine-6-P-deglycase 3835801..3836823 Escherichia coli 55989 7146184 YP_002404720.1 CDS frlC NC_011748.1 3836873 3837703 D YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine; fructoselysine 3-epimerase 3836873..3837703 Escherichia coli 55989 7146185 YP_002404721.1 CDS frlD NC_011748.1 3837700 3838485 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12147680; Product type e : enzyme; fructoselysine 6-kinase 3837700..3838485 Escherichia coli 55989 7146186 YP_002404722.1 CDS frlR NC_011748.1 3838585 3839316 D may act as a transcriptional regulator of a fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes; DNA-binding transcriptional regulator FrlR 3838585..3839316 Escherichia coli 55989 7146187 YP_002404723.1 CDS yhfS NC_011748.1 3839468 3840553 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3839468..3840553) Escherichia coli 55989 7146188 YP_002404724.1 CDS yhfT NC_011748.1 3840565 3841869 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(3840565..3841869) Escherichia coli 55989 7148964 YP_002404725.1 CDS yhfU NC_011748.1 3841881 3842234 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3841881..3842234) Escherichia coli 55989 7148965 YP_002404726.1 CDS php NC_011748.1 3842245 3843123 R phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE); hydrolase complement(3842245..3843123) Escherichia coli 55989 7148966 YP_002404727.1 CDS yhfW NC_011748.1 3843120 3844346 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; mutase complement(3843120..3844346) Escherichia coli 55989 7147187 YP_002404728.1 CDS yhfX NC_011748.1 3844346 3845509 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; amino acid racemase complement(3844346..3845509) Escherichia coli 55989 7148967 YP_002404729.1 CDS yhfY NC_011748.1 3845593 3845955 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3845593..3845955) Escherichia coli 55989 7148968 YP_002404730.1 CDS yhfZ NC_011748.1 3845972 3846877 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3845972..3846877) Escherichia coli 55989 7148969 YP_002404731.1 CDS trpS NC_011748.1 3847146 3848150 R catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; tryptophanyl-tRNA synthetase complement(3847146..3848150) Escherichia coli 55989 7148970 YP_002404732.1 CDS gph NC_011748.1 3848143 3848901 R catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate; phosphoglycolate phosphatase complement(3848143..3848901) Escherichia coli 55989 7147857 YP_002404733.1 CDS rpe NC_011748.1 3848894 3849571 R catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate; ribulose-phosphate 3-epimerase complement(3848894..3849571) Escherichia coli 55989 7146359 YP_002404734.1 CDS dam NC_011748.1 3849589 3850425 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90136529, 92262475, 92272672, 2549371, 6300769, 7603433, 8341592; Product type e : enzyme; DNA adenine methylase complement(3849589..3850425) Escherichia coli 55989 7147460 YP_002404735.1 CDS damX NC_011748.1 3850532 3851818 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3850532..3851818) Escherichia coli 55989 7145847 YP_002404736.1 CDS aroB NC_011748.1 3851910 3852998 R catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis; 3-dehydroquinate synthase complement(3851910..3852998) Escherichia coli 55989 7145848 YP_002404737.1 CDS aroK NC_011748.1 3853055 3853576 R type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis; shikimate kinase I complement(3853055..3853576) Escherichia coli 55989 7145540 YP_002404738.1 CDS hofQ NC_011748.1 3853977 3855215 R outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa; outer membrane porin HofQ complement(3853977..3855215) Escherichia coli 55989 7145547 YP_002404739.1 CDS yrfA NC_011748.1 3855127 3855531 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3855127..3855531) Escherichia coli 55989 7146451 YP_002404740.1 CDS yrfB NC_011748.1 3855521 3855961 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(3855521..3855961) Escherichia coli 55989 7149459 YP_002404741.1 CDS yrfC NC_011748.1 3855945 3856484 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type ps : structure; fimbrial assembly protein (pilN-like) complement(3855945..3856484) Escherichia coli 55989 7149460 YP_002404742.1 CDS yrfD NC_011748.1 3856484 3857263 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; pilus assembly protein complement(3856484..3857263) Escherichia coli 55989 7149461 YP_002404743.1 CDS mrcA NC_011748.1 3857383 3859935 D bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits; peptidoglycan synthetase 3857383..3859935 Escherichia coli 55989 7149462 YP_002404744.1 CDS nudE NC_011748.1 3860103 3860663 R ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose; ADP-ribose diphosphatase NudE complement(3860103..3860663) Escherichia coli 55989 7146898 YP_002404745.1 CDS igaA NC_011748.1 3860983 3863118 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11553591; Product type r : regulator; intracellular growth attenuator protein 3860983..3863118 Escherichia coli 55989 7147039 YP_002404746.1 CDS yrfG NC_011748.1 3863183 3863851 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hydrolase 3863183..3863851 Escherichia coli 55989 7146545 YP_002404747.1 CDS hslR NC_011748.1 3863862 3864263 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9867837, 10675343, 10675344; Product type f : factor; ribosome-associated heat shock protein Hsp15 3863862..3864263 Escherichia coli 55989 7149463 YP_002404748.1 CDS hslO NC_011748.1 3864288 3865166 D becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers; Hsp33-like chaperonin 3864288..3865166 Escherichia coli 55989 7146469 YP_002404749.1 CDS yhgE NC_011748.1 3865301 3867025 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 20223645; Product type pm : membrane component; inner membrane protein complement(3865301..3867025) Escherichia coli 55989 7146468 YP_002404750.1 CDS EC55989_3808 NC_011748.1 3867101 3867232 R Evidence 6 : Doubtful CDS; hypothetical protein complement(3867101..3867232) Escherichia coli 55989 7148972 YP_002404751.1 CDS pck NC_011748.1 3867404 3869026 D PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP; phosphoenolpyruvate carboxykinase 3867404..3869026 Escherichia coli 55989 7145012 YP_002404752.1 CDS EC55989_3810 NC_011748.1 3869143 3869460 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3869143..3869460 Escherichia coli 55989 7147120 YP_002404753.1 CDS EC55989_3811 NC_011748.1 3869519 3869815 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2404279; Product type pr : regulator; HTH-type transcriptional regulator yiaG 3869519..3869815 Escherichia coli 55989 7145013 YP_002404754.1 CDS envZ NC_011748.1 3869845 3871197 R membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR; osmolarity sensor protein complement(3869845..3871197) Escherichia coli 55989 7145014 YP_002404755.1 CDS ompR NC_011748.1 3871194 3871913 R part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation; osmolarity response regulator complement(3871194..3871913) Escherichia coli 55989 7146008 YP_002404756.1 CDS greB NC_011748.1 3872141 3872617 D necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus; transcription elongation factor GreB 3872141..3872617 Escherichia coli 55989 7147070 YP_002404757.1 CDS yhgF NC_011748.1 3872714 3875035 D Evidence 2b : Function of strongly homologous gene; PubMedId : 8755871; Product type f : factor; transcriptional accessory protein 3872714..3875035 Escherichia coli 55989 7146366 YP_002404758.1 CDS feoA NC_011748.1 3875473 3875700 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012482, 8407793; Product type t : transporter; ferrous iron transport protein A 3875473..3875700 Escherichia coli 55989 7148973 YP_002404759.1 CDS feoB NC_011748.1 3875717 3878038 D cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake; ferrous iron transport protein B 3875717..3878038 Escherichia coli 55989 7146086 YP_002404760.1 CDS yhgG NC_011748.1 3878038 3878274 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 3878038..3878274 Escherichia coli 55989 7146087 YP_002404761.1 CDS yhgA NC_011748.1 3878477 3879355 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2678009; Product type ph : phenotype; hypothetical protein 3878477..3879355 Escherichia coli 55989 7148974 YP_002404762.1 CDS bioH NC_011748.1 3879384 3880154 R Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis; carboxylesterase BioH complement(3879384..3880154) Escherichia coli 55989 7148971 YP_002404763.1 CDS gntX NC_011748.1 3880192 3880875 D involved in high-affinity gluconate transport; gluconate periplasmic binding protein 3880192..3880875 Escherichia coli 55989 7145629 YP_002404764.1 CDS gntY NC_011748.1 3880934 3881509 D cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source; DNA uptake protein 3880934..3881509 Escherichia coli 55989 7146354 YP_002404765.1 CDS gntT NC_011748.1 3881870 3883186 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 4574689, 4582156, 93139975, 97141270, 98019089, 2845225, 3040894, 7984428, 9045817; Product type t : transporter; gluconate transporter, high-affinity GNT I system 3881870..3883186 Escherichia coli 55989 7146355 YP_002404766.1 CDS malQ NC_011748.1 3883231 3885315 R amylomaltase; acts to release glucose from maltodextrins; 4-alpha-glucanotransferase complement(3883231..3885315) Escherichia coli 55989 7146352 YP_002404767.1 CDS malP NC_011748.1 3885325 3887718 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 89033892, 10220320, 10469642, 2845225, 3037809, 3155826, 6283313, 6339728, 6986282, 9009262; Product type e : enzyme; maltodextrin phosphorylase complement(3885325..3887718) Escherichia coli 55989 7146775 YP_002404768.1 CDS malT NC_011748.1 3888330 3891035 D Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides; transcriptional regulator MalT 3888330..3891035 Escherichia coli 55989 7146774 YP_002404769.1 CDS rtcA NC_011748.1 3891078 3892094 R catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester; RNA 3'-terminal-phosphate cyclase complement(3891078..3892094) Escherichia coli 55989 7146777 YP_002404770.1 CDS rtcB NC_011748.1 3892098 3893324 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9738023; hypothetical protein complement(3892098..3893324) Escherichia coli 55989 7147552 YP_002404771.1 CDS rtcR NC_011748.1 3893513 3895111 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9738023, 3045764, 7920643, 7984428; Product type r : regulator; sigma 54-dependent transcriptional regulator of rtcBA expression 3893513..3895111 Escherichia coli 55989 7147553 YP_002404772.1 CDS glpR NC_011748.1 3895093 3895851 R represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism; DNA-binding transcriptional repressor GlpR complement(3895093..3895851) Escherichia coli 55989 7147554 YP_002404773.1 CDS glpG NC_011748.1 3895868 3896698 R protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity; intramembrane serine protease GlpG complement(3895868..3896698) Escherichia coli 55989 7146324 YP_002404774.1 CDS glpE NC_011748.1 3896743 3897069 R belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine; thiosulfate sulfurtransferase complement(3896743..3897069) Escherichia coli 55989 7146321 YP_002404775.1 CDS glpD NC_011748.1 3897259 3898764 D in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane; glycerol-3-phosphate dehydrogenase 3897259..3898764 Escherichia coli 55989 7146319 YP_002404776.1 CDS EC55989_3834 NC_011748.1 3898816 3899421 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3898816..3899421) Escherichia coli 55989 7146318 YP_002404777.1 CDS EC55989_3835 NC_011748.1 3899424 3900191 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3899424..3900191) Escherichia coli 55989 7145015 YP_002404778.1 CDS EC55989_3836 NC_011748.1 3900194 3900904 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3900194..3900904) Escherichia coli 55989 7145016 YP_002404779.1 CDS EC55989_3837 NC_011748.1 3900920 3902437 R Evidence 4 : Homologs of previously reported genes of unknown function; membrane protein; ATP binding protein of ABC transporter complement(3900920..3902437) Escherichia coli 55989 7145017 YP_002404780.1 CDS glgP NC_011748.1 3902553 3905000 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88330897, 91104907, 91236706, 2645169, 2975249, 3047129, 3097003; Product type e : enzyme; glycogen phosphorylase complement(3902553..3905000) Escherichia coli 55989 7145018 YP_002404781.1 CDS glgA NC_011748.1 3905019 3906452 R catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose; glycogen synthase complement(3905019..3906452) Escherichia coli 55989 7146295 YP_002404782.1 CDS glgC NC_011748.1 3906452 3907747 R catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate; glucose-1-phosphate adenylyltransferase complement(3906452..3907747) Escherichia coli 55989 7146292 YP_002404783.1 CDS glgX NC_011748.1 3907765 3909738 R catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen; glycogen debranching protein complement(3907765..3909738) Escherichia coli 55989 7146294 YP_002404784.1 CDS glgB NC_011748.1 3909735 3911921 R catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain; glycogen branching protein complement(3909735..3911921) Escherichia coli 55989 7146297 YP_002404785.1 CDS asd NC_011748.1 3912194 3913297 R catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde; aspartate-semialdehyde dehydrogenase complement(3912194..3913297) Escherichia coli 55989 7146293 YP_002404786.1 CDS yhgN NC_011748.1 3913490 3914083 D YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP); dITP- and XTP- hydrolase 3913490..3914083 Escherichia coli 55989 7145563 YP_002404787.1 CDS gntU NC_011748.1 3914140 3915480 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8655507, 9119199, 9135111, 97141270; Product type t : transporter; low affinity gluconate transporter complement(3914140..3915480) Escherichia coli 55989 7148975 YP_002404788.1 CDS gntK NC_011748.1 3915484 3916011 R thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate; gluconate kinase complement(3915484..3916011) Escherichia coli 55989 7146353 YP_002404789.1 CDS gntR NC_011748.1 3916150 3917145 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 9135111, 93139975, 9537375, 8655507; Product type r : regulator; DNA-binding transcriptional repressor complement(3916150..3917145) Escherichia coli 55989 7146349 YP_002404790.1 CDS yhhW NC_011748.1 3917369 3918064 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3917369..3918064) Escherichia coli 55989 7146351 YP_002404791.1 CDS yhhX NC_011748.1 3918187 3919224 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10493123; Product type pe : enzyme; dehydrogenase complement(3918187..3919224) Escherichia coli 55989 7148991 YP_002404792.1 CDS yhhY NC_011748.1 3919556 3920044 D YhhY; regulated by the fur regulator; unknown function; acetyltransferase YhhY 3919556..3920044 Escherichia coli 55989 7147592 YP_002404793.1 CDS yhhZ NC_011748.1 3920281 3921459 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3920281..3921459 Escherichia coli 55989 7148993 YP_002404794.1 CDS yrhA NC_011748.1 3921456 3921950 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3921456..3921950 Escherichia coli 55989 7148994 YP_002404795.1 CDS yrhD NC_011748.1 3922036 3922200 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3922036..3922200 Escherichia coli 55989 7149464 YP_002404796.1 CDS yrhB NC_011748.1 3922400 3922684 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3922400..3922684 Escherichia coli 55989 7149466 YP_002404797.1 CDS ggt NC_011748.1 3922722 3924464 R periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides; gamma-glutamyltranspeptidase complement(3922722..3924464) Escherichia coli 55989 7149465 YP_002404798.1 CDS yhhA NC_011748.1 3924584 3925024 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3924584..3925024 Escherichia coli 55989 7146282 YP_002404799.1 CDS ugpQ NC_011748.1 3925011 3925754 R hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate; glycerophosphodiester phosphodiesterase complement(3925011..3925754) Escherichia coli 55989 7148976 YP_002404800.1 CDS ugpC NC_011748.1 3925751 3926821 R part of the UgpABCE glycerol-3-phosphate uptake system; glycerol-3-phosphate transporter ATP-binding subunit complement(3925751..3926821) Escherichia coli 55989 7147904 YP_002404801.1 CDS ugpE NC_011748.1 3926823 3927668 R with UgpABC is involved in uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter membrane protein complement(3926823..3927668) Escherichia coli 55989 7147902 YP_002404802.1 CDS ugpA NC_011748.1 3927665 3928552 R with UgpEC is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter permease complement(3927665..3928552) Escherichia coli 55989 7147903 YP_002404803.1 CDS ugpB NC_011748.1 3928650 3929966 R with UgpACE is involved in the uptake of glycerol-3-phosphate; glycerol-3-phosphate transporter periplasmic binding protein complement(3928650..3929966) Escherichia coli 55989 7147900 YP_002404804.1 CDS livF NC_011748.1 3930362 3931075 R with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit complement(3930362..3931075) Escherichia coli 55989 7147901 YP_002404805.1 CDS livG NC_011748.1 3931077 3931844 R Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter ATP-binding subunit complement(3931077..3931844) Escherichia coli 55989 7146705 YP_002404806.1 CDS livM NC_011748.1 3931841 3933118 R Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine; leucine/isoleucine/valine transporter permease subunit complement(3931841..3933118) Escherichia coli 55989 7146706 YP_002404807.1 CDS livH NC_011748.1 3933115 3934041 R LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter; branched-chain amino acid transporter permease subunit LivH complement(3933115..3934041) Escherichia coli 55989 7146710 YP_002404808.1 CDS livK NC_011748.1 3934089 3935198 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649683, 3891753, 4077929, 9298646, 9298646; Product type t : transporter; leucine ABC transporter subunit substrate-binding protein complement(3934089..3935198) Escherichia coli 55989 7146707 YP_002404809.1 CDS yhhK NC_011748.1 3935622 3936005 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3935622..3936005 Escherichia coli 55989 7146709 YP_002404810.1 CDS livJ NC_011748.1 3936204 3937307 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702302, 90307651, 2195019, 2649682, 328304, 3891753, 4077929, 9298646, 10972807; Product type t : transporter; leucine/isoleucine/valine transporter subunit ; periplasmic-binding component of ABC superfamily complement(3936204..3937307) Escherichia coli 55989 7148985 YP_002404811.1 CDS rpoH NC_011748.1 3937578 3938432 R binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters; RNA polymerase factor sigma-32 complement(3937578..3938432) Escherichia coli 55989 7146708 YP_002404812.1 CDS ftsX NC_011748.1 3938677 3939735 R ABC transporter, membrane protein; cell division protein FtsX complement(3938677..3939735) Escherichia coli 55989 7147500 YP_002404813.1 CDS ftsE NC_011748.1 3939728 3940396 R ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions; cell division protein FtsE complement(3939728..3940396) Escherichia coli 55989 7146220 YP_002404814.1 CDS ftsY NC_011748.1 3940399 3941892 R signal recognition protein receptor; functions in the targeting and insertion of membrane proteins; cell division protein FtsY complement(3940399..3941892) Escherichia coli 55989 7146212 YP_002404815.1 CDS rsmD NC_011748.1 3942042 3942638 D catalyzes the methylation of 16S rRNA at position G966; 16S rRNA m(2)G966-methyltransferase 3942042..3942638 Escherichia coli 55989 7146221 YP_002404816.1 CDS EC55989_3874 NC_011748.1 3942505 3942897 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 3942505..3942897 Escherichia coli 55989 7148977 YP_002404817.1 CDS yhhM NC_011748.1 3942900 3943259 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3942900..3943259) Escherichia coli 55989 7145019 YP_002404818.1 CDS yhhN NC_011748.1 3943400 3944026 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3943400..3944026 Escherichia coli 55989 7148986 YP_002404819.1 CDS zntA NC_011748.1 3944100 3946298 D P-type ATPase involved in the export of lead, cadmium, zinc and mercury; zinc/cadmium/mercury/lead-transporting ATPase 3944100..3946298 Escherichia coli 55989 7148987 YP_002404820.1 CDS tusA NC_011748.1 3946400 3946645 R TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs; sulfur transfer protein SirA complement(3946400..3946645) Escherichia coli 55989 7149490 YP_002404821.1 CDS yhhQ NC_011748.1 3946866 3947531 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 3946866..3947531 Escherichia coli 55989 7147875 YP_002404822.1 CDS dcrB NC_011748.1 3947604 3948161 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12558182, 8752353; Product type t : transporter; hypothetical protein 3947604..3948161 Escherichia coli 55989 7148988 YP_002404823.1 CDS yhhS NC_011748.1 3948165 3949382 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; major facilitator superfamily transporter complement(3948165..3949382) Escherichia coli 55989 7145858 YP_002404824.1 CDS yhhT NC_011748.1 3949514 3950563 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3949514..3950563 Escherichia coli 55989 7148989 YP_002404825.1 CDS acpT NC_011748.1 3950618 3951205 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20092861, 10625633, 8939709; Product type e : enzyme; holo-(acyl carrier protein) synthase 2 3950618..3951205 Escherichia coli 55989 7148990 YP_002404826.1 CDS nikA NC_011748.1 3951316 3952890 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12960164, 7934931, 92077434, 7867647; Product type t : transporter; nickel transporter subunit ; periplasmic-binding component of ABC superfamily 3951316..3952890 Escherichia coli 55989 7145443 YP_002404827.1 CDS nikB NC_011748.1 3952890 3953834 D with NikACDE is involved in nickel transport into the cell; nickel transporter permease NikB 3952890..3953834 Escherichia coli 55989 7146995 YP_002404828.1 CDS nikC NC_011748.1 3953831 3954664 D with NikABDE is involved in nickel transport into the cell; nickel transporter permease NikC 3953831..3954664 Escherichia coli 55989 7146996 YP_002404829.1 CDS nikD NC_011748.1 3954664 3955428 D with NikABCE is involved in nickel transport into the cell; nickel transporter ATP-binding protein NikD 3954664..3955428 Escherichia coli 55989 7146997 YP_002404830.1 CDS nikE NC_011748.1 3955425 3956231 D with NikABCD is involved with nickel transport into the cell; nickel transporter ATP-binding protein NikE 3955425..3956231 Escherichia coli 55989 7146998 YP_002404831.1 CDS nikR NC_011748.1 3956237 3956638 D Inhibits transcription at high concentrations of nickel; nickel responsive regulator 3956237..3956638 Escherichia coli 55989 7146999 YP_002404832.1 CDS EC55989_3890 NC_011748.1 3956758 3957117 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(3956758..3957117) Escherichia coli 55989 7147000 YP_002404833.1 CDS yhhJ NC_011748.1 3957448 3958572 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter subunit: membrane component of ABC superfamily complement(3957448..3958572) Escherichia coli 55989 7145020 YP_002404834.1 CDS rbbA NC_011748.1 3958572 3961307 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20074572; Product type e : enzyme; fused ribosome-associated ATPase: ATP-binding protein ; ATP-binding protein ; membrane protein complement(3958572..3961307) Escherichia coli 55989 7148984 YP_002404835.1 CDS yhiI NC_011748.1 3961304 3962371 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; HlyD family secretion protein complement(3961304..3962371) Escherichia coli 55989 7147338 YP_002404836.1 CDS yhiM NC_011748.1 3966629 3967681 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 3966629..3967681 Escherichia coli 55989 7145023 YP_002404837.1 CDS EC55989_3900 NC_011748.1 3968341 3968808 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8594334, 16940062, 15518875; Product type h : extrachromosomal origin; hypothetical protein complement(3968341..3968808) Escherichia coli 55989 7149000 YP_002404838.1 CDS EC55989_3901 NC_011748.1 3968993 3970393 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; sensor protein pcoS complement(3968993..3970393) Escherichia coli 55989 7145024 YP_002404839.1 CDS EC55989_3902 NC_011748.1 3970390 3971076 R Transcriptional regulatory protein pcoR complement(3970390..3971076) Escherichia coli 55989 7145025 YP_002404840.1 CDS EC55989_3903 NC_011748.1 3971125 3972054 R Copper resistance protein D complement(3971125..3972054) Escherichia coli 55989 7145026 YP_002404841.1 CDS EC55989_3904 NC_011748.1 3972059 3972439 R Copper resistance protein C precursor complement(3972059..3972439) Escherichia coli 55989 7145027 YP_002404842.1 CDS EC55989_3905 NC_011748.1 3972479 3973378 R Copper resistance protein B precursor complement(3972479..3973378) Escherichia coli 55989 7145028 YP_002404843.1 CDS EC55989_3906 NC_011748.1 3973375 3975198 R Copper resistance protein A precursor complement(3973375..3975198) Escherichia coli 55989 7145029 YP_002404844.1 CDS EC55989_3907 NC_011748.1 3975427 3975876 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 8594334, 15518875, 15276215, 16940062; hypothetical protein 3975427..3975876 Escherichia coli 55989 7145030 YP_002404845.1 CDS EC55989_3908 NC_011748.1 3976165 3976902 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15518875, 15276215, 16940062; Product type pe : enzyme; peptidase 3976165..3976902 Escherichia coli 55989 7145031 YP_002404846.1 CDS silP NC_011748.1 3977174 3979621 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9930866, 15518875, 15276215, 16940062; Product type pt : transporter; cation-transporting P-type ATPase complement(3977174..3979621) Escherichia coli 55989 7145032 YP_002404847.1 CDS EC55989_3911 NC_011748.1 3979748 3980194 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9930866, 15518875, 15276215, 16940062; hypothetical protein complement(3979748..3980194) Escherichia coli 55989 7147658 YP_002404848.1 CDS cusA NC_011748.1 3980275 3983421 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20461235, 21125583, 21178899, 21450803, 11399769, 12813074, 1711024, 7984428; Product type t : transporter; copper/silver efflux system, membrane component complement(3980275..3983421) Escherichia coli 55989 7145033 YP_002404849.1 CDS silB NC_011748.1 3983432 3984724 R with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system membrane fusion protein CusB complement(3983432..3984724) Escherichia coli 55989 7145791 YP_002404850.1 CDS EC55989_3914 NC_011748.1 3984838 3985191 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9930866, 15518875, 16940062; copper-binding protein complement(3984838..3985191) Escherichia coli 55989 7147655 YP_002404851.1 CDS silC NC_011748.1 3985219 3986907 R with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver; copper/silver efflux system outer membrane protein CusC complement(3985219..3986907) Escherichia coli 55989 7145034 YP_002404852.1 CDS cusR NC_011748.1 3986794 3987474 D response regulator in two-component regulatory system with CusS; regulates the copper efflux system; DNA-binding transcriptional activator CusR 3986794..3987474 Escherichia coli 55989 7147656 YP_002404853.1 CDS EC55989_3918 NC_011748.1 3987467 3988948 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type pr : regulator; sensor kinase CusS 3987467..3988948 Escherichia coli 55989 7145796 YP_002404854.1 CDS silE NC_011748.1 3989076 3989624 D Evidence 2b : Function of strongly homologous gene; PubMedId : 9930866; Product type f : factor; silver-binding protein SilE 3989076..3989624 Escherichia coli 55989 7145035 YP_002404855.1 CDS EC55989_3920 NC_011748.1 3989772 3990122 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15518875, 16940062; hypothetical protein 3989772..3990122 Escherichia coli 55989 7147657 YP_002404856.1 CDS EC55989_3921 NC_011748.1 3990291 3992177 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15518875, 16940062; hypothetical protein complement(3990291..3992177) Escherichia coli 55989 7145036 YP_002404857.1 CDS EC55989_3922 NC_011748.1 3992681 3993010 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15518875, 16940062; Product type pr : regulator; transcriptional regulator complement(3992681..3993010) Escherichia coli 55989 7145037 YP_002404858.1 CDS EC55989_3923 NC_011748.1 3993333 3994259 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 15518875, 16940062; hypothetical protein complement(3993333..3994259) Escherichia coli 55989 7145038 YP_002404859.1 CDS EC55989_3924 NC_011748.1 3995125 3995400 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1849492; Product type r : regulator; Insertion element IS1 protein InsA 3995125..3995400 Escherichia coli 55989 7145039 YP_002404860.1 CDS EC55989_3925 NC_011748.1 3995319 3995822 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 273224, 375010, 1849492; Product type pe : enzyme; Insertion element IS1 1/5/6 protein InsB 3995319..3995822 Escherichia coli 55989 7145040 YP_002404861.1 CDS EC55989_3926 NC_011748.1 3995816 3996613 R Evidence 7 : Gene remnant; PubMedId : 2156235, 1655576, 8947057; hypothetical protein, Tn7-like transposition protein TnsD (fragment) complement(3995816..3996613) Escherichia coli 55989 7145041 YP_002404862.1 CDS EC55989_3927 NC_011748.1 3996645 3998093 R Evidence 2b : Function of strongly homologous gene; PubMedId : 2156235, 1655576, 8947057; Product type pe : enzyme; Tn7-like transposition protein TnsC complement(3996645..3998093) Escherichia coli 55989 7145042 YP_002404863.1 CDS EC55989_3928 NC_011748.1 3998093 4000216 R Evidence 2b : Function of strongly homologous gene; PubMedId : 2156235, 1655576, 8947057, 10704304, 1657979; Product type pe : enzyme; Tn7-like transposition protein TnsB complement(3998093..4000216) Escherichia coli 55989 7145043 YP_002404864.1 CDS EC55989_3929 NC_011748.1 4000203 4001045 R Evidence 2b : Function of strongly homologous gene; PubMedId : 2156235, 1655576, 8947057, 10704304; Product type pe : enzyme; Tn7-like transposase TnsA complement(4000203..4001045) Escherichia coli 55989 7145044 YP_002404865.1 CDS yhiN NC_011748.1 4001188 4002390 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase with FAD/NAD(P)-binding domain complement(4001188..4002390) Escherichia coli 55989 7145045 YP_002404866.1 CDS pitA NC_011748.1 4002622 4004121 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87014120; Product type t : transporter; phosphate transporter, low-affinity 4002622..4004121 Escherichia coli 55989 7149001 YP_002404867.1 CDS yhiO NC_011748.1 4004192 4004527 R ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress; universal stress protein UspB complement(4004192..4004527) Escherichia coli 55989 7147191 YP_002404868.1 CDS uspA NC_011748.1 4004918 4005352 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12732303, 93086426, 93308072, 94203056, 10499297, 10652104, 10931298, 11157932, 1453957, 8506346, 8932299, 9298646, 9405142; Product type f : factor; universal stress global response regulator 4004918..4005352 Escherichia coli 55989 7149002 YP_002404869.1 CDS yhiP NC_011748.1 4005670 4007139 D member of the POT family of peptide transporters; probable proton-dependent peptide transporter function; inner membrane transporter YhiP 4005670..4007139 Escherichia coli 55989 7147928 YP_002404870.1 CDS yhiQ NC_011748.1 4007188 4007940 R predicted SAM-dependent methyltransferase; methyltransferase complement(4007188..4007940) Escherichia coli 55989 7149003 YP_002404871.1 CDS prlC NC_011748.1 4007948 4009990 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92394891, 1325967, 8366062; Product type e : enzyme; oligopeptidase A complement(4007948..4009990) Escherichia coli 55989 7149004 YP_002404872.1 CDS yhiR NC_011748.1 4010193 4011035 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11591672; Product type pe : enzyme; DNA (exogenous) processing protein 4010193..4011035 Escherichia coli 55989 7147248 YP_002404873.1 CDS gor NC_011748.1 4011107 4012459 D catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense; glutathione reductase 4011107..4012459 Escherichia coli 55989 7149005 YP_002404874.1 CDS EC55989_3939 NC_011748.1 4012513 4012662 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4012513..4012662) Escherichia coli 55989 7146356 YP_002404875.1 CDS EC55989_3940 NC_011748.1 4012618 4012797 D Evidence 6 : Doubtful CDS; hypothetical protein 4012618..4012797 Escherichia coli 55989 7145046 YP_002404876.1 CDS arsR NC_011748.1 4013336 4013689 D regulates the expression of of the arsRBC involved in resistance to arsenic; DNA-binding transcriptional repressor ArsR 4013336..4013689 Escherichia coli 55989 7145047 YP_002404877.1 CDS arsB NC_011748.1 4013743 4015032 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15004242, 95355341, 1535622, 7721697; Product type t : transporter; arsenite/antimonite transporter 4013743..4015032 Escherichia coli 55989 7145554 YP_002404878.1 CDS arsC NC_011748.1 4015045 4015470 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95355341, 7721697; Product type e : enzyme; arsenate reductase 4015045..4015470 Escherichia coli 55989 7145552 YP_002404879.1 CDS EC55989_3945 NC_011748.1 4015604 4015900 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4015604..4015900) Escherichia coli 55989 7145553 YP_002404880.1 CDS EC55989_3946 NC_011748.1 4015995 4017020 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; hypothetical protein 4015995..4017020 Escherichia coli 55989 7145048 YP_002404881.1 CDS EC55989_3947 NC_011748.1 4017600 4018745 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4017600..4018745 Escherichia coli 55989 7145049 YP_002404882.1 CDS slp NC_011748.1 4019069 4019635 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94293775, 8022277; Product type lp : lipoprotein; outer membrane lipoprotein 4019069..4019635 Escherichia coli 55989 7145050 YP_002404883.1 CDS yhiF NC_011748.1 4019791 4020321 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8022277; Product type pr : regulator; DNA-binding transcriptional regulator 4019791..4020321 Escherichia coli 55989 7147660 YP_002404884.1 CDS yhiD NC_011748.1 4020363 4021010 R inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli; Mg(2+) transport ATPase complement(4020363..4021010) Escherichia coli 55989 7148996 YP_002404885.1 CDS hdeB NC_011748.1 4021074 4021400 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8885264, 12071744, 8244952, 8455549, 9298646, 9868784; Product type pf : factor; acid-resistance protein complement(4021074..4021400) Escherichia coli 55989 7148995 YP_002404886.1 CDS hdeA NC_011748.1 4021516 4021848 R inactive form; acid-resistance protein complement(4021516..4021848) Escherichia coli 55989 7146402 YP_002404887.1 CDS hdeD NC_011748.1 4022103 4022675 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94064579, 8244952, 8455549; Product type pm : membrane component; acid-resistance membrane protein 4022103..4022675 Escherichia coli 55989 7146401 YP_002404888.1 CDS gadE NC_011748.1 4023474 4024001 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12399493, 12940989, 14702398; Product type r : regulator; DNA-binding transcriptional activator 4023474..4024001 Escherichia coli 55989 7146403 YP_002404889.1 CDS mdtE NC_011748.1 4024340 4025497 D with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds; multidrug efflux system protein MdtE 4024340..4025497 Escherichia coli 55989 7146243 YP_002404890.1 CDS mdtF NC_011748.1 4025522 4028635 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803; Product type t : transporter; multidrug transporter, RpoS-dependent 4025522..4028635 Escherichia coli 55989 7146806 YP_002404891.1 CDS gadW NC_011748.1 4028998 4029726 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12446650; Product type r : regulator; DNA-binding transcriptional activator complement(4028998..4029726) Escherichia coli 55989 7146807 YP_002404892.1 CDS gadX NC_011748.1 4030094 4030918 R regulates genes in response to acid and/or during stationary phase; DNA-binding transcriptional regulator GadX complement(4030094..4030918) Escherichia coli 55989 7146246 YP_002404893.1 CDS gadA NC_011748.1 4031288 4032688 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92155241, 92394884, 99406302, 1522060, 1740158, 7764225, 9298646; Product type e : enzyme; glutamate decarboxylase complement(4031288..4032688) Escherichia coli 55989 7146245 YP_002404894.1 CDS yhjA NC_011748.1 4032899 4034296 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8163487, 14563563; Product type e : enzyme; cytochrome C peroxidase (cpp-like) complement(4032899..4034296) Escherichia coli 55989 7146240 YP_002404895.1 CDS treF NC_011748.1 4034701 4036350 D cytoplasmic; catalyzes the hydrolysis of trehalose to glucose; trehalase 4034701..4036350 Escherichia coli 55989 7149006 YP_002404896.1 CDS yhjB NC_011748.1 4036401 4037003 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding response regulator in two-component regulatory system complement(4036401..4037003) Escherichia coli 55989 7147838 YP_002404897.1 CDS yhjC NC_011748.1 4037451 4038422 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 4037451..4038422 Escherichia coli 55989 7149007 YP_002404898.1 CDS yhjD NC_011748.1 4038471 4039484 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4038471..4039484 Escherichia coli 55989 7149008 YP_002404899.1 CDS yhjE NC_011748.1 4039895 4041217 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4039895..4041217 Escherichia coli 55989 7149009 YP_002404900.1 CDS yhjG NC_011748.1 4041451 4043526 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; outer membrane biogenesis protein complement(4041451..4043526) Escherichia coli 55989 7149010 YP_002404901.1 CDS yhjH NC_011748.1 4043581 4044348 R in Escherichia coli this protein is involved in flagellar function; EAL domain-containing protein complement(4043581..4044348) Escherichia coli 55989 7149011 YP_002404902.1 CDS EC55989_3972 NC_011748.1 4044302 4044496 D Evidence 6 : Doubtful CDS; hypothetical protein 4044302..4044496 Escherichia coli 55989 7149012 YP_002404903.1 CDS kdgK NC_011748.1 4044580 4045509 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4359651, 13813474; Product type e : enzyme; ketodeoxygluconokinase 4044580..4045509 Escherichia coli 55989 7145051 YP_002404904.1 CDS yhjJ NC_011748.1 4045605 4047101 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pe : enzyme; zinc-dependent peptidase complement(4045605..4047101) Escherichia coli 55989 7146651 YP_002404905.1 CDS dctA NC_011748.1 4047322 4048608 R involved in the transport of C4-dicarboxylates across the membrane; C4-dicarboxylate transporter DctA complement(4047322..4048608) Escherichia coli 55989 7149013 YP_002404906.1 CDS yhjK NC_011748.1 4048791 4050740 R HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a phosphodiesterase protein from E. coli; phosphodiesterase complement(4048791..4050740) Escherichia coli 55989 7145859 YP_002404907.1 CDS bcsC NC_011748.1 4050861 4054334 R cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA; cellulose synthase subunit BcsC complement(4050861..4054334) Escherichia coli 55989 7149014 YP_002404908.1 CDS bcsZ NC_011748.1 4054316 4055422 R catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans; endo-1,4-D-glucanase complement(4054316..4055422) Escherichia coli 55989 7145604 YP_002404909.1 CDS bcsB NC_011748.1 4055429 4057768 R binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP); cellulose synthase regulator protein complement(4055429..4057768) Escherichia coli 55989 7145608 YP_002404910.1 CDS bcsA NC_011748.1 4057779 4060397 R polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis; cellulose synthase catalytic subunit complement(4057779..4060397) Escherichia coli 55989 7145603 YP_002404911.1 CDS EC55989_3981 NC_011748.1 4060394 4061146 R cell division protein complement(4060394..4061146) Escherichia coli 55989 7145602 YP_002404912.1 CDS yhjR NC_011748.1 4061158 4061346 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4061158..4061346) Escherichia coli 55989 7145052 YP_002404913.1 CDS bcsE NC_011748.1 4061619 4063190 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : enzyme; cellulose biosynthesis protease 4061619..4063190 Escherichia coli 55989 7149015 YP_002404914.1 CDS bcsF NC_011748.1 4063187 4063378 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4063187..4063378 Escherichia coli 55989 7145605 YP_002404915.1 CDS bcsG NC_011748.1 4063375 4065054 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11929533, 11260463; Product type pe : enzyme; cellulose biosynthesis endoglucanase 4063375..4065054 Escherichia coli 55989 7145606 YP_002404916.1 CDS ldrD NC_011748.1 4066107 4066349 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12123448; Product type f : factor; toxic polypeptide, small complement(4066107..4066349) Escherichia coli 55989 7147356 YP_002404917.1 CDS EC55989_3989 NC_011748.1 4066861 4067022 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4066861..4067022) Escherichia coli 55989 7147355 YP_002404918.1 CDS yhjV NC_011748.1 4067172 4068443 D Evidence 2b : Function of strongly homologous gene; PubMedId : 15901718; Product type t : transporter; transporter 4067172..4068443 Escherichia coli 55989 7145053 YP_002404919.1 CDS dppF NC_011748.1 4068473 4069477 R Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides; dipeptide transporter ATP-binding subunit complement(4068473..4069477) Escherichia coli 55989 7149016 YP_002404920.1 CDS dppD NC_011748.1 4069474 4070457 R DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF; dipeptide transporter ATP-binding subunit complement(4069474..4070457) Escherichia coli 55989 7145948 YP_002404921.1 CDS dppC NC_011748.1 4070468 4071370 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 7536291; Product type t : transporter; dipeptide transporter complement(4070468..4071370) Escherichia coli 55989 7145947 YP_002404922.1 CDS dppB NC_011748.1 4071380 4072399 R transports peptides consisting of two or three amino acids; dipeptide transporter permease DppB complement(4071380..4072399) Escherichia coli 55989 7145946 YP_002404923.1 CDS EC55989_3995 NC_011748.1 4072417 4072560 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4072417..4072560 Escherichia coli 55989 7145945 YP_002404924.1 CDS dppA NC_011748.1 4072550 4074157 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100289, 92065799, 1702779, 1956284, 7536291, 8527431, 8563629, 9298646, 9600841, 9740056, 10972807; Product type t : transporter; dipeptide transporter ; periplasmic-binding component of ABC superfamily complement(4072550..4074157) Escherichia coli 55989 7145054 YP_002404925.1 CDS eptB NC_011748.1 4075069 4076760 R catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide; phosphoethanolamine transferase complement(4075069..4076760) Escherichia coli 55989 7145373 YP_002404926.1 CDS lpfE NC_011748.1 4077013 4077537 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type pm : membrane component; LpfE protein precursor complement(4077013..4077537) Escherichia coli 55989 7146019 YP_002404927.1 CDS lpfD NC_011748.1 4077543 4078598 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; LpfD protein precursor complement(4077543..4078598) Escherichia coli 55989 7146730 YP_002404928.1 CDS lpfC NC_011748.1 4078609 4081140 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; Outer membrane usher protein lpfC precursor complement(4078609..4081140) Escherichia coli 55989 7146728 YP_002404929.1 CDS lpfB NC_011748.1 4081164 4081850 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; Chaperone protein lpfB precursor complement(4081164..4081850) Escherichia coli 55989 7146726 YP_002404930.1 CDS lpfA NC_011748.1 4081934 4082458 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 14977923; Product type m : membrane component; Long polar fimbria protein A precursor complement(4081934..4082458) Escherichia coli 55989 7146725 YP_002404931.1 CDS yhjX NC_011748.1 4082782 4084029 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter complement(4082782..4084029) Escherichia coli 55989 7146723 YP_002404932.1 CDS yhjY NC_011748.1 4084213 4084911 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4084213..4084911) Escherichia coli 55989 7149017 YP_002404933.1 CDS tag NC_011748.1 4085069 4085632 D constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine; 3-methyladenine DNA glycosylase 4085069..4085632 Escherichia coli 55989 7149018 YP_002404934.1 CDS yiaC NC_011748.1 4085629 4086069 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11237876; Product type pe : enzyme; hypothetical protein 4085629..4086069 Escherichia coli 55989 7147746 YP_002404935.1 CDS bisC NC_011748.1 4086038 4088317 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 82119950, 90202748, 2180922, 374979; Product type e : enzyme; biotin sulfoxide reductase complement(4086038..4088317) Escherichia coli 55989 7149021 YP_002404936.1 CDS yiaD NC_011748.1 4088524 4089183 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pm : membrane component; outer membrane lipoprotein 4088524..4089183 Escherichia coli 55989 7145632 YP_002404937.1 CDS tiaE NC_011748.1 4089287 4090261 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15801772, 11237876, 99030322, 99357626, 9298646, 9811658; Product type e : enzyme; 2-oxo-carboxylic acid reductase (glyoxalate reductase) (2-ketoaldonate reductase) 4089287..4090261 Escherichia coli 55989 7149022 YP_002404938.1 CDS yiaF NC_011748.1 4090311 4091021 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4090311..4091021) Escherichia coli 55989 7147800 YP_002404939.1 CDS yiaG NC_011748.1 4091455 4091745 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 4091455..4091745 Escherichia coli 55989 7149023 YP_002404940.1 CDS cspA NC_011748.1 4092026 4092238 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20345064, 90115858, 94293754, 94293756, 99177178, 10696873, 1597410, 1961761, 2404279, 7515185, 8197194, 9405743, 9439003, 9692981; Product type f : factor; major cold shock protein 4092026..4092238 Escherichia coli 55989 7149024 YP_002404941.1 CDS glyS NC_011748.1 4092904 4094973 R glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit beta complement(4092904..4094973) Escherichia coli 55989 7145777 YP_002404942.1 CDS glyQ NC_011748.1 4094983 4095894 R glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; glycyl-tRNA synthetase subunit alpha complement(4094983..4095894) Escherichia coli 55989 7146341 YP_002404943.1 CDS ysaB NC_011748.1 4095989 4096288 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4095989..4096288) Escherichia coli 55989 7146340 YP_002404944.1 CDS yiaH NC_011748.1 4096463 4097458 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4096463..4097458 Escherichia coli 55989 7149467 YP_002404945.1 CDS yiaA NC_011748.1 4097500 4097937 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(4097500..4097937) Escherichia coli 55989 7149025 YP_002404946.1 CDS yiaB NC_011748.1 4097983 4098324 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 6320721; Product type pm : membrane component; hypothetical protein complement(4097983..4098324) Escherichia coli 55989 7149019 YP_002404947.1 CDS xylB NC_011748.1 4098493 4099947 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 92366447, 95050816, 6320721; Product type e : enzyme; xylulokinase complement(4098493..4099947) Escherichia coli 55989 7149020 YP_002404948.1 CDS xylA NC_011748.1 4100019 4101341 R catalyzes the interconversion of D-xylose to D-xylulose; xylose isomerase complement(4100019..4101341) Escherichia coli 55989 7147996 YP_002404949.1 CDS xylF NC_011748.1 4101707 4102699 D periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity; D-xylose transporter subunit XylF 4101707..4102699 Escherichia coli 55989 7147995 YP_002404950.1 CDS xylG NC_011748.1 4102777 4104318 D with XylFH is part of the high affinity xylose ABC transporter; xylose transporter ATP-binding subunit 4102777..4104318 Escherichia coli 55989 7147998 YP_002404951.1 CDS xylH NC_011748.1 4104296 4105477 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500; Product type t : transporter; D-xylose transporter subunit ; membrane component of ABC superfamily 4104296..4105477 Escherichia coli 55989 7147999 YP_002404952.1 CDS EC55989_4024 NC_011748.1 4105389 4105565 D Evidence 6 : Doubtful CDS; hypothetical protein 4105389..4105565 Escherichia coli 55989 7148000 YP_002404953.1 CDS xylR NC_011748.1 4105555 4106733 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 6330500, 94316500; Product type r : regulator; DNA-binding transcriptional activator, xylose-binding 4105555..4106733 Escherichia coli 55989 7145055 YP_002404954.1 CDS bax NC_011748.1 4106929 4107753 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 1544897; hypothetical protein complement(4106929..4107753) Escherichia coli 55989 7148001 YP_002404955.1 CDS malS NC_011748.1 4108073 4110103 D periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds; periplasmic alpha-amylase 4108073..4110103 Escherichia coli 55989 7145599 YP_002404956.1 CDS avtA NC_011748.1 4110281 4111534 D transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis; valine--pyruvate transaminase 4110281..4111534 Escherichia coli 55989 7146776 YP_002404957.1 CDS yiaI NC_011748.1 4111686 4112159 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; hydrogenase, 4Fe-4S ferredoxin-type component complement(4111686..4112159) Escherichia coli 55989 7145589 YP_002404958.1 CDS yiaJ NC_011748.1 4112261 4113109 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 20372646, 9826648; Product type r : regulator; DNA-binding transcriptional repressor complement(4112261..4113109) Escherichia coli 55989 7149026 YP_002404959.1 CDS yiaK NC_011748.1 4113310 4114308 D NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate; 2,3-diketo-L-gulonate reductase 4113310..4114308 Escherichia coli 55989 7149027 YP_002404960.1 CDS yiaL NC_011748.1 4114320 4114787 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 21617392; hypothetical protein 4114320..4114787 Escherichia coli 55989 7149028 YP_002404961.1 CDS yiaM NC_011748.1 4114905 4115378 D membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO; 2,3-diketo-L-gulonate TRAP transporter small permease 4114905..4115378 Escherichia coli 55989 7149029 YP_002404962.1 CDS yiaN NC_011748.1 4115381 4116658 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 4115381..4116658 Escherichia coli 55989 7149030 YP_002404963.1 CDS yiaO NC_011748.1 4116671 4117657 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14668138, 21617392; Product type t : transporter; transporter 4116671..4117657 Escherichia coli 55989 7149031 YP_002404964.1 CDS lyxK NC_011748.1 4117661 4119157 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21617392, 95050816, 7961955; Product type e : enzyme; L-xylulose kinase 4117661..4119157 Escherichia coli 55989 7149032 YP_002404965.1 CDS sgbH NC_011748.1 4119154 4119816 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate; 3-keto-L-gulonate-6-phosphate decarboxylase 4119154..4119816 Escherichia coli 55989 7146761 YP_002404966.1 CDS sgbU NC_011748.1 4119809 4120669 D L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate; L-xylulose 5-phosphate 3-epimerase 4119809..4120669 Escherichia coli 55989 7147648 YP_002404967.1 CDS sgbE NC_011748.1 4120663 4121358 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4120663..4121358 Escherichia coli 55989 7147649 YP_002404968.1 CDS yiaT NC_011748.1 4121705 4122445 R Evidence 4 : Homologs of previously reported genes of unknown function; outer membrane protein complement(4121705..4122445) Escherichia coli 55989 7147647 YP_002404969.1 CDS yiaU NC_011748.1 4122569 4123543 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 4122569..4123543 Escherichia coli 55989 7149033 YP_002404970.1 CDS yiaV NC_011748.1 4123540 4124676 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15668009; Product type t : transporter; membrane fusion protein (MFP) component of efflux pump, signal anchor complement(4123540..4124676) Escherichia coli 55989 7149034 YP_002404971.1 CDS yiaW NC_011748.1 4124682 4125005 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(4124682..4125005) Escherichia coli 55989 7149035 YP_002404972.1 CDS EC55989_4045 NC_011748.1 4125119 4125331 D Evidence 4 : Homologs of previously reported genes of unknown function; membrane protein 4125119..4125331 Escherichia coli 55989 7149036 YP_002404973.1 CDS aldB NC_011748.1 4125550 4127088 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95286498, 7768815; Product type e : enzyme; aldehyde dehydrogenase complement(4125550..4127088) Escherichia coli 55989 7145056 YP_002404974.1 CDS yiaY NC_011748.1 4127253 4128404 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 2935393; Product type e : enzyme; alcohol dehydrogenase complement(4127253..4128404) Escherichia coli 55989 7145480 YP_002404975.1 CDS selB NC_011748.1 4128594 4130438 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264431, 91317715, 9315303, 94148228, 2140572, 2531290; Product type f : factor; selenocysteinyl-tRNA-specific translation factor complement(4128594..4130438) Escherichia coli 55989 7149037 YP_002404976.1 CDS selA NC_011748.1 4130435 4131826 R catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis; selenocysteine synthase complement(4130435..4131826) Escherichia coli 55989 7147629 YP_002404977.1 CDS yibF NC_011748.1 4131924 4132532 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8387990; Product type pe : enzyme; glutathione S-transferase complement(4131924..4132532) Escherichia coli 55989 7147628 YP_002404978.1 CDS EC55989_4051 NC_011748.1 4132531 4132674 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4132531..4132674 Escherichia coli 55989 7149041 YP_002404979.1 CDS rhsB NC_011748.1 4132761 4136726 D Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 2403547, 2644231, 7934896, 8387990; Product type h : extrachromosomal origin; rhsB element core protein RshB 4132761..4136726 Escherichia coli 55989 7145057 YP_002404980.1 CDS yhhH NC_011748.1 4136968 4137351 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4136968..4137351 Escherichia coli 55989 7147400 YP_002404981.1 CDS EC55989_4055 NC_011748.1 4137970 4138473 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 273224, 375010, 1849492; Product type pe : enzyme; Insertion element IS1 1/5/6 protein InsB complement(4137970..4138473) Escherichia coli 55989 7149038 YP_002404982.1 CDS EC55989_4056 NC_011748.1 4138392 4138667 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1849492; Product type r : regulator; Insertion element IS1 protein InsA complement(4138392..4138667) Escherichia coli 55989 7145058 YP_002404983.1 CDS EC55989_4058 NC_011748.1 4139117 4140061 D Evidence 4 : Homologs of previously reported genes of unknown function; rhs protein (modular protein) 4139117..4140061 Escherichia coli 55989 7149039 YP_002404984.1 CDS yibG NC_011748.1 4140073 4140534 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4140073..4140534 Escherichia coli 55989 7145060 YP_002404985.1 CDS yibH NC_011748.1 4142133 4143269 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4142133..4143269) Escherichia coli 55989 7145061 YP_002404986.1 CDS yibI NC_011748.1 4143272 4143634 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(4143272..4143634) Escherichia coli 55989 7149043 YP_002404987.1 CDS mtlA NC_011748.1 4144171 4146084 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92052139, 92283796, 94131964, 1946374, 3135464, 3142516, 6309813, 9551558; Product type t : transporter; fused mannitol-specific PTS enzymes: IIA components ; IIB components ; IIC components 4144171..4146084 Escherichia coli 55989 7149044 YP_002404988.1 CDS mtlD NC_011748.1 4146314 4147462 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90254197, 1964486, 3135464, 6384188, 8300537, 13295236; Product type e : enzyme; mannitol-1-phosphate 5-dehydrogenase 4146314..4147462 Escherichia coli 55989 7146914 YP_002404989.1 CDS mtlR NC_011748.1 4147462 4148049 D Acts as a repressor of the mtlAD operon; mannitol repressor protein 4147462..4148049 Escherichia coli 55989 7146915 YP_002404990.1 CDS yibT NC_011748.1 4148061 4148270 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4148061..4148270) Escherichia coli 55989 7146916 YP_002404991.1 CDS yibL NC_011748.1 4148555 4148917 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4148555..4148917 Escherichia coli 55989 7149049 YP_002404992.1 CDS EC55989_4068 NC_011748.1 4149461 4150144 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4149461..4150144 Escherichia coli 55989 7149046 YP_002404993.1 CDS EC55989_4069 NC_011748.1 4150188 4155038 D Evidence 4 : Homologs of previously reported genes of unknown function; adhesin 4150188..4155038 Escherichia coli 55989 7145062 YP_002404994.1 CDS lldP NC_011748.1 4155407 4157062 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94012541, 11283302, 11785976, 8407843; Product type t : transporter; L-lactate permease 4155407..4157062 Escherichia coli 55989 7145063 YP_002404995.1 CDS lldR NC_011748.1 4157062 4157838 D represses the lctPRD operon; DNA-binding transcriptional repressor LldR 4157062..4157838 Escherichia coli 55989 7146712 YP_002404996.1 CDS lldD NC_011748.1 4157835 4159025 D flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration; L-lactate dehydrogenase 4157835..4159025 Escherichia coli 55989 7146713 YP_002404997.1 CDS yibK NC_011748.1 4159211 4159684 D member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates; tRNA/rRNA methyltransferase YibK 4159211..4159684 Escherichia coli 55989 7146711 YP_002404998.1 CDS cysE NC_011748.1 4159737 4160558 R catalyzes the O-acetylation of serine; serine acetyltransferase complement(4159737..4160558) Escherichia coli 55989 7149045 YP_002404999.1 CDS gpsA NC_011748.1 4160638 4161657 R catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase complement(4160638..4161657) Escherichia coli 55989 7145824 YP_002405000.1 CDS secB NC_011748.1 4161657 4162124 R molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be to SecA; preprotein translocase subunit SecB complement(4161657..4162124) Escherichia coli 55989 7146363 YP_002405001.1 CDS grxC NC_011748.1 4162187 4162438 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94316500, 95024051, 99175138, 11031118, 7937896, 8636094, 9973569; Product type c : carrier; glutaredoxin 3 complement(4162187..4162438) Escherichia coli 55989 7147621 YP_002405002.1 CDS yibN NC_011748.1 4162580 4163011 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; rhodanese-related sulfurtransferase complement(4162580..4163011) Escherichia coli 55989 7146372 YP_002405003.1 CDS gpmI NC_011748.1 4163256 4164800 D catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate; phosphoglyceromutase 4163256..4164800 Escherichia coli 55989 7149047 YP_002405004.1 CDS envC NC_011748.1 4164834 4166093 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12113939, 21972773; Product type cp : cell process; hypothetical protein 4164834..4166093 Escherichia coli 55989 7146361 YP_002405005.1 CDS yibQ NC_011748.1 4166097 4167056 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; polysaccharide deacetylase 4166097..4167056 Escherichia coli 55989 7146005 YP_002405006.1 CDS yibD NC_011748.1 4167043 4168077 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15659689, 2647748; Product type pe : enzyme; glycosyl transferase family protein complement(4167043..4168077) Escherichia coli 55989 7149048 YP_002405007.1 CDS tdh NC_011748.1 4168316 4169341 R converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism; L-threonine 3-dehydrogenase complement(4168316..4169341) Escherichia coli 55989 7149040 YP_002405008.1 CDS kbl NC_011748.1 4169351 4170547 R catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine; 2-amino-3-ketobutyrate CoA ligase complement(4169351..4170547) Escherichia coli 55989 7147771 YP_002405009.1 CDS htrL NC_011748.1 4170822 4171679 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4170822..4171679) Escherichia coli 55989 7146649 YP_002405010.1 CDS rfaD NC_011748.1 4171983 4172915 D catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose; ADP-L-glycero-D-manno-heptose-6-epimerase 4171983..4172915 Escherichia coli 55989 7146479 YP_002405011.1 CDS waaF NC_011748.1 4172925 4173971 D catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core; ADP-heptose--LPS heptosyltransferase 4172925..4173971 Escherichia coli 55989 7147957 YP_002405012.1 CDS waaC NC_011748.1 4173975 4174967 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20507564, 92250420, 93239678, 9446588, 1624462, 8478319; Product type e : enzyme; ADP-heptose--LPS heptosyltransferase 4173975..4174967 Escherichia coli 55989 7147958 YP_002405013.1 CDS rfaL NC_011748.1 4174964 4176172 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1657881; Product type e : enzyme; O-antigen ligase 4174964..4176172 Escherichia coli 55989 7147956 YP_002405014.1 CDS rfaK NC_011748.1 4176208 4177350 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Lipopolysaccharide 1, 2-N-acetylglucosaminetransferase complement(4176208..4177350) Escherichia coli 55989 7147379 YP_002405015.1 CDS rfaJ NC_011748.1 4177359 4178372 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92210496, 92250420, 92325066, 99251135, 1624461; Product type e : enzyme; Lipopolysaccharide 1,2-glucosyltransferase complement(4177359..4178372) Escherichia coli 55989 7147378 YP_002405016.1 CDS rfaY NC_011748.1 4178397 4179104 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1624462, 8041620, 9278503, 92250420, 92325067, 9756860; Product type e : enzyme; lipopolysaccharide core biosynthesis protein complement(4178397..4179104) Escherichia coli 55989 7147377 YP_002405017.1 CDS rfaI NC_011748.1 4179130 4180137 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92210496, 92250420, 92325066, 9765561, 1624461; Product type e : enzyme; Lipopolysaccharide 1,3-galactosyltransferase complement(4179130..4180137) Escherichia coli 55989 7147380 YP_002405018.1 CDS waaP NC_011748.1 4180180 4180986 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21101922, 92121133, 92210496, 9756860, 1732225; Product type e : enzyme; kinase that phosphorylates core heptose of lipopolysaccharide complement(4180180..4180986) Escherichia coli 55989 7147376 YP_002405019.1 CDS waaG NC_011748.1 4180970 4182094 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92121133, 92210496, 92250420, 1447141, 1732225, 7988890; Product type e : enzyme; glucosyltransferase I complement(4180970..4182094) Escherichia coli 55989 7147960 YP_002405020.1 CDS waaQ NC_011748.1 4182091 4183149 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9756860, 1447141, 1732225; Product type e : enzyme; lipopolysaccharide core biosynthesis protein complement(4182091..4183149) Escherichia coli 55989 7147959 YP_002405021.1 CDS kdtA NC_011748.1 4183562 4184839 D catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A; 3-deoxy-D-manno-octulosonic-acid transferase 4183562..4184839 Escherichia coli 55989 7147961 YP_002405022.1 CDS coaD NC_011748.1 4184847 4185326 D Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA; phosphopantetheine adenylyltransferase 4184847..4185326 Escherichia coli 55989 7146663 YP_002405023.1 CDS mutM NC_011748.1 4185365 4186174 R Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases; formamidopyrimidine-DNA glycosylase complement(4185365..4186174) Escherichia coli 55989 7145733 YP_002405024.1 CDS rpmG NC_011748.1 4186272 4186439 R in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif; 50S ribosomal protein L33 complement(4186272..4186439) Escherichia coli 55989 7146933 YP_002405025.1 CDS rpmB NC_011748.1 4186460 4186696 R required for 70S ribosome assembly; 50S ribosomal protein L28 complement(4186460..4186696) Escherichia coli 55989 7147492 YP_002405026.1 CDS radC NC_011748.1 4186913 4187581 R Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase; DNA repair protein RadC complement(4186913..4187581) Escherichia coli 55989 7147487 YP_002405027.1 CDS dfp NC_011748.1 4187753 4188973 D catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine; bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase 4187753..4188973 Escherichia coli 55989 7149060 YP_002405028.1 CDS dut NC_011748.1 4188954 4189409 D catalyzes the formation of dUMP from dUTP; deoxyuridine 5'-triphosphate nucleotidohydrolase 4188954..4189409 Escherichia coli 55989 7145893 YP_002405029.1 CDS slmA NC_011748.1 4189516 4190112 D FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly; nucleoid occlusion protein 4189516..4190112 Escherichia coli 55989 7145962 YP_002405030.1 CDS pyrE NC_011748.1 4190149 4190790 R involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate; orotate phosphoribosyltransferase complement(4190149..4190790) Escherichia coli 55989 7147871 YP_002405031.1 CDS rph NC_011748.1 4190856 4191596 R RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs; ribonuclease PH complement(4190856..4191596) Escherichia coli 55989 7147320 YP_002405032.1 CDS yicC NC_011748.1 4191699 4192562 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4191699..4192562 Escherichia coli 55989 7147461 YP_002405033.1 CDS dinD NC_011748.1 4192771 4193607 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 913680, 94334998, 95095962, 1925027, 2158980, 2664418, 8002613, 8057377, 8195095; Product type cp : cell process; DNA-damage-inducible protein D 4192771..4193607 Escherichia coli 55989 7149050 YP_002405034.1 CDS yicG NC_011748.1 4193899 4194516 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4193899..4194516 Escherichia coli 55989 7145915 YP_002405035.1 CDS ligB NC_011748.1 4194513 4196195 R this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+; NAD-dependent DNA ligase LigB complement(4194513..4196195) Escherichia coli 55989 7149052 YP_002405036.1 CDS gmk NC_011748.1 4196453 4197076 D Essential for recycling GMP and indirectly, cGMP; guanylate kinase 4196453..4197076 Escherichia coli 55989 7146701 YP_002405037.1 CDS rpoZ NC_011748.1 4197131 4197406 D promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits; DNA-directed RNA polymerase subunit omega 4197131..4197406 Escherichia coli 55989 7146344 YP_002405038.1 CDS spoT NC_011748.1 4197425 4199533 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12224635, 89255395, 93266525, 94068533, 2005134, 2549050; Product type e : enzyme; bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase 4197425..4199533 Escherichia coli 55989 7147503 YP_002405039.1 CDS trmH NC_011748.1 4199540 4200229 D specifically modifies tRNA at position G18; tRNA guanosine-2'-O-methyltransferase 4199540..4200229 Escherichia coli 55989 7147693 YP_002405040.1 CDS recG NC_011748.1 4200235 4202316 D catalyzes branch migration in Holliday junction intermediates; ATP-dependent DNA helicase RecG 4200235..4202316 Escherichia coli 55989 7147848 YP_002405041.1 CDS gltS NC_011748.1 4202482 4203687 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91203811, 93106943, 1544582, 2017136, 2254324; Product type t : transporter; glutamate transporter complement(4202482..4203687) Escherichia coli 55989 7147362 YP_002405042.1 CDS yicE NC_011748.1 4203967 4205358 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4203967..4205358 Escherichia coli 55989 7146335 YP_002405043.1 CDS yicH NC_011748.1 4205479 4207188 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4205479..4207188 Escherichia coli 55989 7149051 YP_002405044.1 CDS yicI NC_011748.1 4207241 4209559 R catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides; alpha-xylosidase complement(4207241..4209559) Escherichia coli 55989 7149053 YP_002405045.1 CDS yicJ NC_011748.1 4209569 4210951 R may be involved in the transport of galactosides-pentoses-hexuronides; transporter complement(4209569..4210951) Escherichia coli 55989 7149054 YP_002405046.1 CDS EC55989_4125 NC_011748.1 4211444 4211593 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4211444..4211593 Escherichia coli 55989 7145346 YP_002405047.1 CDS setC NC_011748.1 4211975 4213159 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10438463, 10209755; Product type pt : transporter; sugar efflux system 4211975..4213159 Escherichia coli 55989 7145064 YP_002405048.1 CDS yicL NC_011748.1 4213270 4214193 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4213270..4214193 Escherichia coli 55989 7147638 YP_002405049.1 CDS nlpA NC_011748.1 4214197 4215015 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88298691, 89359178, 9914480, 3003106; Product type lp : lipoprotein; hypothetical protein complement(4214197..4215015) Escherichia coli 55989 7149056 YP_002405050.1 CDS yicS NC_011748.1 4215237 4215530 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4215237..4215530 Escherichia coli 55989 7147006 YP_002405051.1 CDS nepI NC_011748.1 4215571 4216926 R experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS; ribonucleoside transporter complement(4215571..4216926) Escherichia coli 55989 7149061 YP_002405052.1 CDS yicN NC_011748.1 4216972 4217424 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4216972..4217424) Escherichia coli 55989 7149057 YP_002405053.1 CDS yicO NC_011748.1 4217477 4218811 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; xanthine/uracil permease complement(4217477..4218811) Escherichia coli 55989 7149058 YP_002405054.1 CDS ade NC_011748.1 4218986 4220752 D catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type; cryptic adenine deaminase 4218986..4220752 Escherichia coli 55989 7149059 YP_002405055.1 CDS uhpT NC_011748.1 4220797 4222188 R cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate; sugar phosphate antiporter complement(4220797..4222188) Escherichia coli 55989 7145454 YP_002405056.1 CDS uhpC NC_011748.1 4222326 4223645 R membrane protein regulates uhpT expression; regulatory protein UhpC complement(4222326..4223645) Escherichia coli 55989 7147908 YP_002405057.1 CDS uhpB NC_011748.1 4223655 4225157 R Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph; sensory histidine kinase UhpB complement(4223655..4225157) Escherichia coli 55989 7147907 YP_002405058.1 CDS uhpA NC_011748.1 4225157 4225747 R response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter; DNA-binding transcriptional activator UhpA complement(4225157..4225747) Escherichia coli 55989 7147906 YP_002405059.1 CDS ilvN NC_011748.1 4225822 4226112 R with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit; acetolactate synthase 1 regulatory subunit complement(4225822..4226112) Escherichia coli 55989 7147905 YP_002405060.1 CDS ilvB NC_011748.1 4226116 4227804 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 2989782, 85242083, 92380929, 2989781; Product type e : enzyme; acetolactate synthase catalytic subunit complement(4226116..4227804) Escherichia coli 55989 7146559 YP_002405062.1 CDS ivbL NC_011748.1 4227910 4228008 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; ilvB operon leader peptide complement(4227910..4228008) Escherichia coli 55989 7145065 YP_002405063.1 CDS EC55989_4141 NC_011748.1 4228537 4228788 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4228537..4228788) Escherichia coli 55989 7146636 YP_002405064.1 CDS emrD NC_011748.1 4229081 4230265 D multidrug efflux protein involved in adaptation to low energy shock; multidrug resistance protein D 4229081..4230265 Escherichia coli 55989 7145066 YP_002405065.1 CDS yidF NC_011748.1 4230273 4230770 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(4230273..4230770) Escherichia coli 55989 7145991 YP_002405066.1 CDS yidG NC_011748.1 4230767 4231129 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(4230767..4231129) Escherichia coli 55989 7149067 YP_002405067.1 CDS yidH NC_011748.1 4231119 4231466 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(4231119..4231466) Escherichia coli 55989 7149068 YP_002405068.1 CDS yidI NC_011748.1 4231575 4232024 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4231575..4232024 Escherichia coli 55989 7149069 YP_002405069.1 CDS yidJ NC_011748.1 4232071 4233564 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; sulfatase/phosphatase complement(4232071..4233564) Escherichia coli 55989 7149070 YP_002405070.1 CDS yidK NC_011748.1 4233561 4235276 R uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function; symporter YidK complement(4233561..4235276) Escherichia coli 55989 7149071 YP_002405071.1 CDS yidL NC_011748.1 4235413 4236336 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 4235413..4236336 Escherichia coli 55989 7149072 YP_002405072.1 CDS EC55989_4152 NC_011748.1 4237147 4239024 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; PTS system alpha-glucoside-specific EIICB component complement(4237147..4239024) Escherichia coli 55989 7145068 YP_002405073.1 CDS yidP NC_011748.1 4239059 4239775 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 4239059..4239775 Escherichia coli 55989 7145069 YP_002405074.1 CDS yidE NC_011748.1 4239772 4241433 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1356969; Product type pt : transporter; hypothetical protein complement(4239772..4241433) Escherichia coli 55989 7149074 YP_002405075.1 CDS ibpB NC_011748.1 4241630 4242058 R 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent; heat shock chaperone IbpB complement(4241630..4242058) Escherichia coli 55989 7149066 YP_002405076.1 CDS ibpA NC_011748.1 4242170 4242583 R with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; heat shock protein IbpA complement(4242170..4242583) Escherichia coli 55989 7146532 YP_002405077.1 CDS yidQ NC_011748.1 4242889 4243221 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 4242889..4243221 Escherichia coli 55989 7146531 YP_002405078.1 CDS yidR NC_011748.1 4243223 4244437 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4243223..4244437) Escherichia coli 55989 7149075 YP_002405079.1 CDS cbrA NC_011748.1 4244538 4245602 D FAD/NAD(P)-binding domain; oxidoreductase 4244538..4245602 Escherichia coli 55989 7149076 YP_002405080.1 CDS dgoT NC_011748.1 4245599 4246891 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type t : transporter; D-galactonate transporter complement(4245599..4246891) Escherichia coli 55989 7145669 YP_002405081.1 CDS dgoD NC_011748.1 4247011 4248159 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; galactonate dehydratase complement(4247011..4248159) Escherichia coli 55989 7145899 YP_002405082.1 CDS dgoA NC_011748.1 4248156 4248773 R catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism; 2-dehydro-3-deoxy-6-phosphogalactonate aldolase complement(4248156..4248773) Escherichia coli 55989 7145896 YP_002405083.1 CDS dgoK NC_011748.1 4248757 4249635 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 79020349; Product type e : enzyme; 2-oxo-3-deoxygalactonate kinase complement(4248757..4249635) Escherichia coli 55989 7145895 YP_002405084.1 CDS dgoR NC_011748.1 4249632 4250321 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 79020349; Product type pr : regulator; DNA-binding transcriptional regulator complement(4249632..4250321) Escherichia coli 55989 7145897 YP_002405085.1 CDS yidX NC_011748.1 4250599 4251255 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; hypothetical protein 4250599..4251255 Escherichia coli 55989 7145898 YP_002405086.1 CDS yidA NC_011748.1 4251301 4252113 R YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins; sugar phosphatase complement(4251301..4252113) Escherichia coli 55989 7149077 YP_002405087.1 CDS yidB NC_011748.1 4252228 4252626 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4252228..4252626) Escherichia coli 55989 7149062 YP_002405088.1 CDS gyrB NC_011748.1 4252866 4255280 R negatively supercoils closed circular double-stranded DNA; DNA gyrase subunit B complement(4252866..4255280) Escherichia coli 55989 7149063 YP_002405089.1 CDS recF NC_011748.1 4255309 4256382 R Required for DNA replication; binds preferentially to single-stranded, linear DNA; recombination protein F complement(4255309..4256382) Escherichia coli 55989 7146389 YP_002405090.1 CDS dnaN NC_011748.1 4256382 4257482 R binds the polymerase to DNA and acts as a sliding clamp; DNA polymerase III subunit beta complement(4256382..4257482) Escherichia coli 55989 7147361 YP_002405091.1 CDS dnaA NC_011748.1 4257487 4258890 R binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.; chromosomal replication initiation protein complement(4257487..4258890) Escherichia coli 55989 7145939 YP_002405092.1 CDS rpmH NC_011748.1 4259497 4259637 D in Escherichia coli transcription of this gene is enhanced by polyamines; 50S ribosomal protein L34 4259497..4259637 Escherichia coli 55989 7145932 YP_002405093.1 CDS rnpA NC_011748.1 4259654 4260013 D protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates; ribonuclease P 4259654..4260013 Escherichia coli 55989 7147493 YP_002405094.1 CDS yidD NC_011748.1 4259977 4260234 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4259977..4260234 Escherichia coli 55989 7147453 YP_002405095.1 CDS yidC NC_011748.1 4260237 4261883 D functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria; inner membrane protein translocase component YidC 4260237..4261883 Escherichia coli 55989 7149065 YP_002405096.1 CDS trmE NC_011748.1 4261989 4263353 D in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE; tRNA modification GTPase TrmE 4261989..4263353 Escherichia coli 55989 7149064 YP_002405097.1 CDS tnaC NC_011748.1 4263596 4263670 D Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; tryptophanase leader peptide 4263596..4263670 Escherichia coli 55989 7147847 YP_002405098.1 CDS tnaA NC_011748.1 4263891 4265306 D tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan; tryptophanase 4263891..4265306 Escherichia coli 55989 7147810 YP_002405099.1 CDS tnaB NC_011748.1 4265397 4266644 D tryptophan transporter of low affinity; tryptophan permease TnaB 4265397..4266644 Escherichia coli 55989 7147808 YP_002405100.1 CDS mdtL NC_011748.1 4266777 4267952 D Confers resistance to chloramphenicol; multidrug efflux system protein MdtL 4266777..4267952 Escherichia coli 55989 7147809 YP_002405101.1 CDS yidZ NC_011748.1 4267927 4268886 D Involved in anaerobic NO protection; DNA-binding transcriptional regulator YidZ 4267927..4268886 Escherichia coli 55989 7146813 YP_002405102.1 CDS yieE NC_011748.1 4269031 4269792 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; phosphopantetheinyl transferase 4269031..4269792 Escherichia coli 55989 7149078 YP_002405103.1 CDS yieF NC_011748.1 4269814 4270380 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14766567; Product type e : enzyme; chromate reductase, Class I, flavoprotein 4269814..4270380 Escherichia coli 55989 7149079 YP_002405104.1 CDS yieG NC_011748.1 4270434 4271771 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(4270434..4271771) Escherichia coli 55989 7149080 YP_002405105.1 CDS yieH NC_011748.1 4271938 4272603 D YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily; 6-phosphogluconate phosphatase 4271938..4272603 Escherichia coli 55989 7149081 YP_002405106.1 CDS yieI NC_011748.1 4272670 4273143 D might be involved in hypersensitivity to nitrofurzone; inner membrane protein 4272670..4273143 Escherichia coli 55989 7149082 YP_002405107.1 CDS cbrC NC_011748.1 4273192 4273779 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4273192..4273779 Escherichia coli 55989 7149083 YP_002405108.1 CDS yieK NC_011748.1 4273841 4274563 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; 6-phosphogluconolactonase complement(4273841..4274563) Escherichia coli 55989 7145670 YP_002405109.1 CDS yieL NC_011748.1 4274578 4275774 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; xylanase complement(4274578..4275774) Escherichia coli 55989 7149084 YP_002405110.1 CDS bglH NC_011748.1 4275774 4277390 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10027967; Product type t : transporter; carbohydrate-specific outer membrane porin, cryptic complement(4275774..4277390) Escherichia coli 55989 7149085 YP_002405111.1 CDS bglB NC_011748.1 4277476 4278870 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87222180, 88297127, 92334140, 3034860, 3309161; Product type e : enzyme; cryptic phospho-beta-glucosidase B complement(4277476..4278870) Escherichia coli 55989 7145621 YP_002405112.1 CDS bglF NC_011748.1 4278889 4280766 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system beta-glucoside-specific transporter subunit IIABC complement(4278889..4280766) Escherichia coli 55989 7145617 YP_002405113.1 CDS phoU NC_011748.1 4282022 4282747 R regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon; transcriptional regulator PhoU complement(4282022..4282747) Escherichia coli 55989 7145620 YP_002405114.1 CDS pstB NC_011748.1 4282762 4283535 R ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation; phosphate transporter ATP-binding protein complement(4282762..4283535) Escherichia coli 55989 7147186 YP_002405115.1 CDS pstA NC_011748.1 4283626 4284516 R Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PtsA complement(4283626..4284516) Escherichia coli 55989 7147278 YP_002405116.1 CDS pstC NC_011748.1 4284516 4285475 R part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions; phosphate transporter permease subunit PstC complement(4284516..4285475) Escherichia coli 55989 7147277 YP_002405117.1 CDS pstS NC_011748.1 4285562 4286602 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90133909, 2215649, 6321434, 6365894, 9228942, 9298646, 9671506; Product type t : transporter; phosphate ABC transporter substrate-binding protein complement(4285562..4286602) Escherichia coli 55989 7147279 YP_002405118.1 CDS lpfD NC_011748.1 4286850 4287923 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12438351, 7721701, 16128397; Product type ps : structure; fimbrial protein LpfD; adhesin complement(4286850..4287923) Escherichia coli 55989 7147280 YP_002405119.1 CDS lpfC NC_011748.1 4287934 4290456 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 7721701, 16128397; Product type pt : transporter; fimbrial usher complement(4287934..4290456) Escherichia coli 55989 7146729 YP_002405120.1 CDS lfpB NC_011748.1 4290481 4291212 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16128397, 12438351; Product type pc : carrier; fimbrial chaperone protein complement(4290481..4291212) Escherichia coli 55989 7146727 YP_002405121.1 CDS lpfA NC_011748.1 4291260 4291832 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16125910, 12438351; Product type ps : structure; major fimbrial subunit complement(4291260..4291832) Escherichia coli 55989 7146697 YP_002405122.1 CDS glmS NC_011748.1 4292134 4293963 R Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source; glucosamine--fructose-6-phosphate aminotransferase complement(4292134..4293963) Escherichia coli 55989 7146724 YP_002405123.1 CDS glmU NC_011748.1 4294125 4295495 R forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis; bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase complement(4294125..4295495) Escherichia coli 55989 7146300 YP_002405124.1 CDS atpC NC_011748.1 4295846 4296265 R part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane; ATP synthase F0F1 subunit epsilon complement(4295846..4296265) Escherichia coli 55989 7146301 YP_002405125.1 CDS atpD NC_011748.1 4296286 4297668 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit; ATP synthase F0F1 subunit beta complement(4296286..4297668) Escherichia coli 55989 7145582 YP_002405126.1 CDS atpG NC_011748.1 4297695 4298558 R Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit; ATP synthase F0F1 subunit gamma complement(4297695..4298558) Escherichia coli 55989 7145583 YP_002405127.1 CDS atpA NC_011748.1 4298609 4300150 R produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit; ATP synthase F0F1 subunit alpha complement(4298609..4300150) Escherichia coli 55989 7145586 YP_002405128.1 CDS atpH NC_011748.1 4300163 4300696 R Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex; ATP synthase F0F1 subunit delta complement(4300163..4300696) Escherichia coli 55989 7145580 YP_002405129.1 CDS atpF NC_011748.1 4300711 4301181 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel.; ATP synthase F0F1 subunit B complement(4300711..4301181) Escherichia coli 55989 7145587 YP_002405130.1 CDS atpE NC_011748.1 4301243 4301482 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0; ATP synthase F0F1 subunit C complement(4301243..4301482) Escherichia coli 55989 7145585 YP_002405131.1 CDS atpB NC_011748.1 4301529 4302344 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0; ATP synthase F0F1 subunit A complement(4301529..4302344) Escherichia coli 55989 7145584 YP_002405132.1 CDS atpI NC_011748.1 4302353 4302733 R Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation; F0F1 ATP synthase subunit I complement(4302353..4302733) Escherichia coli 55989 7145581 YP_002405133.1 CDS gidB NC_011748.1 4303350 4303973 R glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA; 16S rRNA methyltransferase GidB complement(4303350..4303973) Escherichia coli 55989 7145588 YP_002405134.1 CDS gidA NC_011748.1 4304037 4305926 R GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs; tRNA uridine 5-carboxymethylaminomethyl modification protein GidA complement(4304037..4305926) Escherichia coli 55989 7146284 YP_002405135.1 CDS mioC NC_011748.1 4306305 4306748 R An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group; flavodoxin complement(4306305..4306748) Escherichia coli 55989 7146283 YP_002405136.1 CDS asnC NC_011748.1 4306838 4307296 R transcriptional repressor of asnA which codes for aspartate-ammonia ligase; DNA-binding transcriptional regulator AsnC complement(4306838..4307296) Escherichia coli 55989 7146860 YP_002405137.1 CDS asnA NC_011748.1 4307448 4308440 D catalyzes the formation of asparagine from aspartate and ammonia; asparagine synthetase AsnA 4307448..4308440 Escherichia coli 55989 7145569 YP_002405138.1 CDS yieM NC_011748.1 4308445 4309896 R contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA; hypothetical protein complement(4308445..4309896) Escherichia coli 55989 7145567 YP_002405139.1 CDS ravA NC_011748.1 4309890 4311386 R interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase; regulatory ATPase RavA complement(4309890..4311386) Escherichia coli 55989 7149086 YP_002405140.1 CDS trkD NC_011748.1 4311609 4313477 D Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH; potassium transport protein Kup 4311609..4313477 Escherichia coli 55989 7147337 YP_002405141.1 CDS rbsD NC_011748.1 4313644 4314063 D cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source; D-ribose pyranase 4313644..4314063 Escherichia coli 55989 7147842 YP_002405142.1 CDS rbsA NC_011748.1 4314071 4315576 D with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain; D-ribose transporter ATP-binding protein 4314071..4315576 Escherichia coli 55989 7147344 YP_002405143.1 CDS rbsC NC_011748.1 4315581 4316546 D functions to transport ribose at high affinity; forms a complex with RbsA2C2B; ribose ABC transporter permease 4315581..4316546 Escherichia coli 55989 7147341 YP_002405144.1 CDS rbsB NC_011748.1 4316571 4317461 D periplasmic substrate-binding component of the ATP-dependent ribose transport system; D-ribose transporter subunit RbsB 4316571..4317461 Escherichia coli 55989 7147343 YP_002405145.1 CDS rbsK NC_011748.1 4317587 4318516 D catalyzes the formation of D-ribose 5-phosphate from ribose; ribokinase 4317587..4318516 Escherichia coli 55989 7147342 YP_002405146.1 CDS rbsR NC_011748.1 4318520 4319512 D DNA-binding transcriptional repressor of ribose metabolism; transcriptional repressor RbsR 4318520..4319512 Escherichia coli 55989 7147345 YP_002405147.1 CDS hsrA NC_011748.1 4319478 4320905 R Evidence 2b : Function of strongly homologous gene; PubMedId : 20218988, 12107133; Product type t : transporter; multidrug or homocysteine efflux system complement(4319478..4320905) Escherichia coli 55989 7147346 YP_002405148.1 CDS yieP NC_011748.1 4320928 4321620 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator complement(4320928..4321620) Escherichia coli 55989 7146472 YP_002405149.1 CDS hdfR NC_011748.1 4327421 4328260 R Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon; transcriptional regulator HdfR complement(4327421..4328260) Escherichia coli 55989 7145349 YP_002405150.1 CDS yifE NC_011748.1 4328379 4328717 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4328379..4328717 Escherichia coli 55989 7146404 YP_002405151.1 CDS yifB NC_011748.1 4328742 4330292 R among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function; ATP-dependent protease complement(4328742..4330292) Escherichia coli 55989 7149089 YP_002405152.1 CDS ilvL NC_011748.1 4330615 4330713 D Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; ilvG operon leader peptide 4330615..4330713 Escherichia coli 55989 7149088 YP_002405153.1 CDS ilvG NC_011748.1 4330853 4332499 D catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit; acetolactate synthase 2 catalytic subunit 4330853..4332499 Escherichia coli 55989 7146557 YP_002405154.1 CDS ilvM NC_011748.1 4332496 4332759 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92332418, 92380929, 1569580, 3550695, 3897211; Product type e : enzyme; acetolactate synthase 2 regulatory subunit 4332496..4332759 Escherichia coli 55989 7146554 YP_002405155.1 CDS ilvE NC_011748.1 4332779 4333708 D catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids; branched-chain amino acid aminotransferase 4332779..4333708 Escherichia coli 55989 7146558 YP_002405156.1 CDS ilvD NC_011748.1 4333773 4335623 D catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis; dihydroxy-acid dehydratase 4333773..4335623 Escherichia coli 55989 7146553 YP_002405157.1 CDS ilvA NC_011748.1 4335626 4337170 D threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway; threonine dehydratase 4335626..4337170 Escherichia coli 55989 7146552 YP_002405158.1 CDS ilvY NC_011748.1 4337222 4338115 R participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate; DNA-binding transcriptional regulator IlvY complement(4337222..4338115) Escherichia coli 55989 7146549 YP_002405159.1 CDS ilvC NC_011748.1 4338265 4339740 D catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis; ketol-acid reductoisomerase 4338265..4339740 Escherichia coli 55989 7146562 YP_002405160.1 CDS ppiC NC_011748.1 4339827 4340108 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94215709, 7878732, 7925971, 8163020; Product type e : enzyme; peptidyl-prolyl cis-trans isomerase C complement(4339827..4340108) Escherichia coli 55989 7146551 YP_002405161.1 CDS EC55989_4248 NC_011748.1 4340307 4340798 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4340307..4340798) Escherichia coli 55989 7147230 YP_002405162.1 CDS rep NC_011748.1 4340973 4342994 D single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication; ATP-dependent DNA helicase Rep 4340973..4342994 Escherichia coli 55989 7145070 YP_002405163.1 CDS gpp NC_011748.1 4343041 4344525 R catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation; guanosine pentaphosphate phosphohydrolase complement(4343041..4344525) Escherichia coli 55989 7147373 YP_002405164.1 CDS rhlB NC_011748.1 4344659 4345924 R enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation; ATP-dependent RNA helicase RhlB complement(4344659..4345924) Escherichia coli 55989 7146362 YP_002405165.1 CDS trxA NC_011748.1 4346055 4346384 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90202710, 91154193, 92250497, 99175138, 10489448, 1094461, 10947986, 1561103, 2181145, 2193685, 3891733, 4616096, 4883076, 6098320, 6099324, 7812718, 8098620, 8253691; Product type c : carrier; thioredoxin 4346055..4346384 Escherichia coli 55989 7147396 YP_002405166.1 CDS rhoL NC_011748.1 4346525 4346626 D Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; rho operon leader peptide 4346525..4346626 Escherichia coli 55989 7147862 YP_002405167.1 CDS rho NC_011748.1 4346711 4347970 D An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes; transcription termination factor Rho 4346711..4347970 Escherichia coli 55989 7147399 YP_002405168.1 CDS EC55989_4255 NC_011748.1 4347980 4348198 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4347980..4348198 Escherichia coli 55989 7147398 YP_002405169.1 CDS rfe NC_011748.1 4348210 4349313 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92114763, 94245613, 94292435, 10629198, 11024259, 11700352, 11832520, 1722555, 1730666; Product type e : enzyme; UDP-GlcNAc:undecaprenylphosphate GlcNAc-1-phosphate transferase 4348210..4349313 Escherichia coli 55989 7145071 YP_002405170.1 CDS wzzE NC_011748.1 4349325 4350371 D Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein; lipopolysaccharide biosynthesis protein WzzE 4349325..4350371 Escherichia coli 55989 7147381 YP_002405171.1 CDS rffE NC_011748.1 4350427 4351557 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 94042873, 11106477, 7559340, 8170390, 8226648; Product type e : enzyme; UDP-N-acetyl glucosamine-2-epimerase 4350427..4351557 Escherichia coli 55989 7147980 YP_002405172.1 CDS wecC NC_011748.1 4351554 4352816 D catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid; UDP-N-acetyl-D-mannosamine dehydrogenase 4351554..4352816 Escherichia coli 55989 7147385 YP_002405173.1 CDS rffG NC_011748.1 4352816 4353883 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086930, 90212314, 90337949, 92112804, 92174908, 94018634, 94042873, 7559340; Product type e : enzyme; dTDP-glucose 4,6-dehydratase 4352816..4353883 Escherichia coli 55989 7147384 YP_002405174.1 CDS rffH NC_011748.1 4353902 4354783 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94292435, 96032389; Product type e : enzyme; glucose-1-phosphate thymidylyltransferase 4353902..4354783 Escherichia coli 55989 7147386 YP_002405175.1 CDS rffC NC_011748.1 4354761 4355435 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90212314, 90337949, 92112804, 8366065; Product type e : enzyme; TDP-fucosamine acetyltransferase 4354761..4355435 Escherichia coli 55989 7147387 YP_002405176.1 CDS rffA NC_011748.1 4355440 4356570 D catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis; TDP-4-oxo-6-deoxy-D-glucose transaminase 4355440..4356570 Escherichia coli 55989 7147383 YP_002405177.1 CDS wzxE NC_011748.1 4356572 4357822 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12621029, 20044778; Product type t : transporter; O-antigen translocase 4356572..4357822 Escherichia coli 55989 7147382 YP_002405178.1 CDS rffT NC_011748.1 4357819 4358898 D catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis; 4-alpha-L-fucosyltransferase 4357819..4358898 Escherichia coli 55989 7147978 YP_002405179.1 CDS wzyE NC_011748.1 4358895 4360247 D enterobacterial common antigen polymerase; common antigen polymerase 4358895..4360247 Escherichia coli 55989 7147389 YP_002405180.1 CDS rffM NC_011748.1 4360250 4360990 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88086874, 90337949, 92112804; Product type e : enzyme; UDP-N-acetyl-D-mannosaminuronic acid transferase 4360250..4360990 Escherichia coli 55989 7147979 YP_002405181.1 CDS yifK NC_011748.1 4361181 4362566 D uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function; transporter 4361181..4362566 Escherichia coli 55989 7147388 YP_002405182.1 CDS aslB NC_011748.1 4363252 4364487 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 11222759, 2180918, 12419807, 14749327; Product type pr : regulator; regulator of arylsulfatase activity 4363252..4364487 Escherichia coli 55989 7145354 YP_002405183.1 CDS hemY NC_011748.1 4365411 4366607 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89041586; Product type pe : enzyme; protoheme IX biogenesis protein complement(4365411..4366607) Escherichia coli 55989 7147593 YP_002405184.1 CDS hemX NC_011748.1 4366610 4367815 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 89098348, 92358234, 3054815, 3062586, 9298646; Product type pe : enzyme; uroporphyrinogen III C-methyltransferase complement(4366610..4367815) Escherichia coli 55989 7146418 YP_002405185.1 CDS hemD NC_011748.1 4367837 4368577 R catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis; uroporphyrinogen-III synthase complement(4367837..4368577) Escherichia coli 55989 7146417 YP_002405186.1 CDS hemC NC_011748.1 4368574 4369515 R transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis; porphobilinogen deaminase complement(4368574..4369515) Escherichia coli 55989 7146410 YP_002405187.1 CDS cyaA NC_011748.1 4369902 4372448 D catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP; adenylate cyclase 4369902..4372448 Escherichia coli 55989 7146409 YP_002405188.1 CDS cyaY NC_011748.1 4372488 4372808 R defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly; frataxin-like protein complement(4372488..4372808) Escherichia coli 55989 7145802 YP_002405189.1 CDS EC55989_4278 NC_011748.1 4372856 4374181 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4372856..4374181) Escherichia coli 55989 7145803 YP_002405190.1 CDS EC55989_4279 NC_011748.1 4374178 4375686 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4374178..4375686) Escherichia coli 55989 7145072 YP_002405191.1 CDS EC55989_4280 NC_011748.1 4376024 4376578 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4376024..4376578) Escherichia coli 55989 7145073 YP_002405192.1 CDS EC55989_4281 NC_011748.1 4376585 4376719 R Evidence 6 : Doubtful CDS; hypothetical protein complement(4376585..4376719) Escherichia coli 55989 7145074 YP_002405193.1 CDS yifL NC_011748.1 4376928 4377131 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; lipoprotein 4376928..4377131 Escherichia coli 55989 7145075 YP_002405194.1 CDS dapF NC_011748.1 4377168 4377992 D involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate; diaminopimelate epimerase 4377168..4377992 Escherichia coli 55989 7149091 YP_002405195.1 CDS yigA NC_011748.1 4377989 4378696 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4377989..4378696 Escherichia coli 55989 7145853 YP_002405196.1 CDS xerC NC_011748.1 4378693 4379589 D site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs; site-specific tyrosine recombinase XerC 4378693..4379589 Escherichia coli 55989 7149092 YP_002405197.1 CDS yigB NC_011748.1 4379589 4380305 D YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function; flavin mononucleotide phosphatase 4379589..4380305 Escherichia coli 55989 7147989 YP_002405198.1 CDS uvrD NC_011748.1 4380389 4382551 D unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.; DNA-dependent helicase II 4380389..4382551 Escherichia coli 55989 7149093 YP_002405199.1 CDS yigE NC_011748.1 4382698 4383462 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4382698..4383462) Escherichia coli 55989 7147936 YP_002405200.1 CDS corA NC_011748.1 4383832 4384782 D responsible for the influx of magnesium ions; magnesium/nickel/cobalt transporter CorA 4383832..4384782 Escherichia coli 55989 7149094 YP_002405201.1 CDS EC55989_4290 NC_011748.1 4384824 4385315 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4384824..4385315) Escherichia coli 55989 7145743 YP_002405202.1 CDS EC55989_4291 NC_011748.1 4385312 4386166 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4385312..4386166) Escherichia coli 55989 7145076 YP_002405203.1 CDS EC55989_4292 NC_011748.1 4386290 4386493 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4386290..4386493 Escherichia coli 55989 7145077 YP_002405204.1 CDS EC55989_4293 NC_011748.1 4386518 4386796 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4386518..4386796) Escherichia coli 55989 7145078 YP_002405205.1 CDS EC55989_4294 NC_011748.1 4386573 4386689 D hypothetical protein 4386573..4386689 Escherichia coli 55989 7145079 YP_002405206.1 CDS EC55989_4295 NC_011748.1 4387076 4387420 D Evidence 4 : Homologs of previously reported genes of unknown function; membrane protein 4387076..4387420 Escherichia coli 55989 7145080 YP_002405207.1 CDS rarD NC_011748.1 4387467 4388354 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; chloramphenicol resistance permease complement(4387467..4388354) Escherichia coli 55989 7145081 YP_002405208.1 CDS yigI NC_011748.1 4388406 4388873 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4388406..4388873) Escherichia coli 55989 7147336 YP_002405209.1 CDS pldA NC_011748.1 4389038 4389907 D catalyzes the hydrolysis of phosphatidylcholine; phospholipase A 4389038..4389907 Escherichia coli 55989 7149095 YP_002405210.1 CDS recQ NC_011748.1 4390040 4391869 D functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway; ATP-dependent DNA helicase RecQ 4390040..4391869 Escherichia coli 55989 7147193 YP_002405211.1 CDS rhtC NC_011748.1 4391933 4392553 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596, 3027506; Product type t : transporter; threonine efflux system 4391933..4392553 Escherichia coli 55989 7147366 YP_002405212.1 CDS rhtB NC_011748.1 4392615 4393235 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 99313167, 10386596; Product type t : transporter; homoserine/homoserine lactone efflux protein complement(4392615..4393235) Escherichia coli 55989 7147408 YP_002405213.1 CDS pldB NC_011748.1 4393346 4394368 D lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates; lysophospholipase L2 4393346..4394368 Escherichia coli 55989 7147407 YP_002405214.1 CDS yigL NC_011748.1 4394376 4395176 D purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium; sugar phosphatase 4394376..4395176 Escherichia coli 55989 7147194 YP_002405215.1 CDS yigM NC_011748.1 4395252 4396151 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4395252..4396151 Escherichia coli 55989 7149096 YP_002405216.1 CDS metR NC_011748.1 4396039 4396992 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90384950, 96303520, 2205852, 2643109; Product type r : regulator; DNA-binding transcriptional activator, homocysteine-binding complement(4396039..4396992) Escherichia coli 55989 7149097 YP_002405217.1 CDS metE NC_011748.1 4397110 4399371 D catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine; 5- methyltetrahydropteroyltriglutamate/homocysteine S-methyltransferase 4397110..4399371 Escherichia coli 55989 7146837 YP_002405218.1 CDS ysgA NC_011748.1 4399410 4400225 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12676709; Product type pe : enzyme; hydrolase complement(4399410..4400225) Escherichia coli 55989 7146827 YP_002405219.1 CDS udp NC_011748.1 4400487 4401248 D catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway; uridine phosphorylase 4400487..4401248 Escherichia coli 55989 7149468 YP_002405220.1 CDS rmuC NC_011748.1 4401389 4402816 D YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner; DNA recombination protein RmuC 4401389..4402816 Escherichia coli 55989 7147898 YP_002405221.1 CDS ubiE NC_011748.1 4402911 4403666 D Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone; ubiquinone/menaquinone biosynthesis methyltransferase 4402911..4403666 Escherichia coli 55989 7147431 YP_002405222.1 CDS yigP NC_011748.1 4403680 4404285 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4403680..4404285 Escherichia coli 55989 7147891 YP_002405223.1 CDS ubiB NC_011748.1 4404282 4405922 D an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions; ubiquinone biosynthesis protein UbiB 4404282..4405922 Escherichia coli 55989 7149098 YP_002405224.1 CDS tatA NC_011748.1 4406001 4406270 D TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes; twin arginine translocase protein A 4406001..4406270 Escherichia coli 55989 7147888 YP_002405225.1 CDS tatB NC_011748.1 4406274 4406789 D mediates the export of protein precursors bearing twin-arginine signal peptides; sec-independent translocase 4406274..4406789 Escherichia coli 55989 7147753 YP_002405226.1 CDS tatC NC_011748.1 4406792 4407568 D with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane; twin-arginine protein translocation system subunit TatC 4406792..4407568 Escherichia coli 55989 7147754 YP_002405227.1 CDS tatD NC_011748.1 4407610 4408392 D magnesium dependent; not involved in the Sec-independent protein export system; DNase TatD 4407610..4408392 Escherichia coli 55989 7147755 YP_002405228.1 CDS rfaH NC_011748.1 4408389 4408877 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92011415, 92250420, 92261317, 1584020, 12007406; Product type r : regulator; transcriptional activator RfaH complement(4408389..4408877) Escherichia coli 55989 7147756 YP_002405229.1 CDS ubiD NC_011748.1 4409044 4410537 D catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol; 3-octaprenyl-4-hydroxybenzoate carboxy-lyase 4409044..4410537 Escherichia coli 55989 7147375 YP_002405230.1 CDS fre NC_011748.1 4410583 4411284 D NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin; FMN reductase 4410583..4411284 Escherichia coli 55989 7147890 YP_002405231.1 CDS fadA NC_011748.1 4411476 4412639 R FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; 3-ketoacyl-CoA thiolase complement(4411476..4412639) Escherichia coli 55989 7146183 YP_002405232.1 CDS fadB NC_011748.1 4412649 4414838 R includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids; multifunctional fatty acid oxidation complex subunit alpha complement(4412649..4414838) Escherichia coli 55989 7146055 YP_002405233.1 CDS pepQ NC_011748.1 4415028 4416359 D catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters; proline dipeptidase 4415028..4416359 Escherichia coli 55989 7146056 YP_002405234.1 CDS yigZ NC_011748.1 4416359 4416973 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15103642; Product type pf : factor; hypothetical protein 4416359..4416973 Escherichia coli 55989 7147136 YP_002405235.1 CDS trkH NC_011748.1 4417012 4418463 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100357, 2243799, 7896723; Product type t : transporter; potassium transporter 4417012..4418463 Escherichia coli 55989 7149099 YP_002405236.1 CDS hemG NC_011748.1 4418475 4419020 D catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX; protoporphyrinogen oxidase 4418475..4419020 Escherichia coli 55989 7147843 YP_002405237.1 CDS mobB NC_011748.1 4424604 4425116 R in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway; molybdopterin-guanine dinucleotide biosynthesis protein B complement(4424604..4425116) Escherichia coli 55989 7145292 YP_002405238.1 CDS mobA NC_011748.1 4425113 4425697 R in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis; molybdopterin-guanine dinucleotide biosynthesis protein MobA complement(4425113..4425697) Escherichia coli 55989 7146878 YP_002405239.1 CDS yihD NC_011748.1 4425767 4426036 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4425767..4426036 Escherichia coli 55989 7146877 YP_002405240.1 CDS yihE NC_011748.1 4426113 4427099 D catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages; serine/threonine protein kinase 4426113..4427099 Escherichia coli 55989 7149101 YP_002405241.1 CDS dsbA NC_011748.1 4427116 4427742 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12498799, 93264419, 94016574, 94206930, 99298180, 10210188, 1429594, 1740115, 1934062, 8413591, 8494885, 8521518, 9194175, 9298646, 9300489, 9572841, 9600841, 9655827; Product type e : enzyme; protein disulfide isomerase I 4427116..4427742 Escherichia coli 55989 7149102 YP_002405242.1 CDS yihF NC_011748.1 4427897 4429327 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4427897..4429327 Escherichia coli 55989 7145950 YP_002405243.1 CDS yihG NC_011748.1 4429368 4430300 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acyltransferase complement(4429368..4430300) Escherichia coli 55989 7149103 YP_002405244.1 CDS polA NC_011748.1 4430664 4433450 D has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair; DNA polymerase I 4430664..4433450 Escherichia coli 55989 7149104 YP_002405245.1 CDS engB NC_011748.1 4433832 4434428 R binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential; ribosome biogenesis GTP-binding protein YsxC complement(4433832..4434428) Escherichia coli 55989 7147692 YP_002405246.1 CDS yihI NC_011748.1 4435046 4435555 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4435046..4435555 Escherichia coli 55989 7145785 YP_002405247.1 CDS hemN NC_011748.1 4435744 4437117 D catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III; coproporphyrinogen III oxidase 4435744..4437117 Escherichia coli 55989 7149105 YP_002405248.1 CDS glnG NC_011748.1 4437529 4438938 R response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54; nitrogen regulation protein NR(I) complement(4437529..4438938) Escherichia coli 55989 7146416 YP_002405249.1 CDS glnL NC_011748.1 4438950 4439999 R sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation; nitrogen regulation protein NR(II) complement(4438950..4439999) Escherichia coli 55989 7146306 YP_002405250.1 CDS glnA NC_011748.1 4440285 4441694 R forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme; glutamine synthetase complement(4440285..4441694) Escherichia coli 55989 7146309 YP_002405251.1 CDS EC55989_4346 NC_011748.1 4441822 4441974 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4441822..4441974) Escherichia coli 55989 7146302 YP_002405252.1 CDS bipA NC_011748.1 4442067 4443890 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9642082, 7783627, 9298646, 9622352; Product type f : factor; GTP-binding protein 4442067..4443890 Escherichia coli 55989 7145082 YP_002405253.1 CDS yihL NC_011748.1 4444106 4444816 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 4444106..4444816 Escherichia coli 55989 7145630 YP_002405254.1 CDS yihM NC_011748.1 4444824 4445804 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; sugar phosphate isomerase 4444824..4445804 Escherichia coli 55989 7149106 YP_002405255.1 CDS yihN NC_011748.1 4445906 4447171 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4445906..4447171 Escherichia coli 55989 7149107 YP_002405256.1 CDS EC55989_4351 NC_011748.1 4447282 4448070 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DEOR-type transcriptional regulator complement(4447282..4448070) Escherichia coli 55989 7149108 YP_002405257.1 CDS EC55989_4352 NC_011748.1 4448110 4449045 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; sugar kinase complement(4448110..4449045) Escherichia coli 55989 7145083 YP_002405258.1 CDS EC55989_4353 NC_011748.1 4448978 4450057 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase with NAD(P)-binding Rossmann-fold domain, 3-hydroxyisobutyrate dehydrogenase 4448978..4450057 Escherichia coli 55989 7145084 YP_002405259.1 CDS EC55989_4354 NC_011748.1 4450082 4450969 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; aldolase yihT 4450082..4450969 Escherichia coli 55989 7145085 YP_002405260.1 CDS EC55989_4355 NC_011748.1 4451002 4452012 D Evidence 4 : Homologs of previously reported genes of unknown function; dehydrogenase, GroES-like protein 4451002..4452012 Escherichia coli 55989 7145086 YP_002405261.1 CDS EC55989_4356 NC_011748.1 4452082 4453515 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4452082..4453515 Escherichia coli 55989 7145087 YP_002405262.1 CDS EC55989_4357 NC_011748.1 4453614 4454963 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transport protein 4453614..4454963 Escherichia coli 55989 7145088 YP_002405263.1 CDS EC55989_4358 NC_011748.1 4454896 4455840 D Evidence 4 : Homologs of previously reported genes of unknown function; galactose mutarotase 4454896..4455840 Escherichia coli 55989 7145089 YP_002405264.1 CDS yihX NC_011748.1 4455981 4456580 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; phosphatase 4455981..4456580 Escherichia coli 55989 7145090 YP_002405265.1 CDS rbn NC_011748.1 4456574 4457446 D RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease; ribonuclease BN 4456574..4457446 Escherichia coli 55989 7149109 YP_002405266.1 CDS dtd NC_011748.1 4457443 4457880 D hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine; D-tyrosyl-tRNA(Tyr) deacylase 4457443..4457880 Escherichia coli 55989 7147340 YP_002405267.1 CDS yiiD NC_011748.1 4457877 4458866 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acetyltransferase 4457877..4458866 Escherichia coli 55989 7145959 YP_002405268.1 CDS EC55989_4363 NC_011748.1 4458930 4459913 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; lipase complement(4458930..4459913) Escherichia coli 55989 7149110 YP_002405269.1 CDS EC55989_4364 NC_011748.1 4460067 4460378 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4460067..4460378 Escherichia coli 55989 7145091 YP_002405270.1 CDS EC55989_4365 NC_011748.1 4460379 4460669 D Evidence 4 : Homologs of previously reported genes of unknown function; transcriptional regulator 4460379..4460669 Escherichia coli 55989 7145092 YP_002405271.1 CDS yiiE NC_011748.1 4461255 4461473 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 4461255..4461473 Escherichia coli 55989 7145093 YP_002405272.1 CDS yiiF NC_011748.1 4461717 4461935 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4461717..4461935 Escherichia coli 55989 7149111 YP_002405273.1 CDS fdhE NC_011748.1 4462265 4463194 R required for the formation of active formate dehydrogenase; formate dehydrogenase accessory protein FdhE complement(4462265..4463194) Escherichia coli 55989 7149112 YP_002405274.1 CDS fdoI NC_011748.1 4463191 4463826 R cytochrome b556(FDO) component; heme containing; formate dehydrogenase-O subunit gamma complement(4463191..4463826) Escherichia coli 55989 7146067 YP_002405275.1 CDS fdoH NC_011748.1 4463823 4464725 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91317715, 8522521, 9852007; Product type c : carrier; formate dehydrogenase-O, Fe-S subunit complement(4463823..4464725) Escherichia coli 55989 7146074 YP_002405276.1 CDS fdoG NC_011748.1 4464738 4467788 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-O, large subunit complement(4464738..4467788) Escherichia coli 55989 7146073 YP_002405277.1 CDS fdhD NC_011748.1 4467982 4468815 D involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth; formate dehydrogenase accessory protein 4467982..4468815 Escherichia coli 55989 7146072 YP_002405278.1 CDS yiiG NC_011748.1 4468968 4470008 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4468968..4470008 Escherichia coli 55989 7146066 YP_002405279.1 CDS frvR NC_011748.1 4470058 4471806 R repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system; frv operon regulatory protein complement(4470058..4471806) Escherichia coli 55989 7149113 YP_002405280.1 CDS frvX NC_011748.1 4471806 4472876 R with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars; fructose-specific phosphotransferase system protein FrvX complement(4471806..4472876) Escherichia coli 55989 7146201 YP_002405281.1 CDS frvB NC_011748.1 4472866 4474317 R Evidence 2b : Function of strongly homologous gene; PubMedId : 94290319; Product type t : transporter; PTS system transporter subunits IIBC complement(4472866..4474317) Escherichia coli 55989 7146202 YP_002405282.1 CDS frvA NC_011748.1 4474328 4474774 R with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system; fructose-like phosphotransferase system subunit EIIA complement(4474328..4474774) Escherichia coli 55989 7146200 YP_002405283.1 CDS yiiL NC_011748.1 4475087 4475401 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15060078; Product type e : enzyme; L-rhamnose mutarotase complement(4475087..4475401) Escherichia coli 55989 7146199 YP_002405284.1 CDS rhaD NC_011748.1 4475411 4476235 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90128204, 93374854, 8396120; Product type e : enzyme; rhamnulose-1-phosphate aldolase complement(4475411..4476235) Escherichia coli 55989 7149114 YP_002405285.1 CDS rhaA NC_011748.1 4476477 4477736 R catalyzes the formation of L-rhamnulose from L-rhamnose; L-rhamnose isomerase complement(4476477..4477736) Escherichia coli 55989 7147392 YP_002405286.1 CDS rhaB NC_011748.1 4477733 4479202 R catalyzes the ATP-dependent phosphorylation of rhamnulose; rhamnulokinase complement(4477733..4479202) Escherichia coli 55989 7147390 YP_002405287.1 CDS rhaS NC_011748.1 4479490 4480326 D activates the expression of the rhaBAD operon and rhaT gene; transcriptional activator RhaS 4479490..4480326 Escherichia coli 55989 7147391 YP_002405288.1 CDS rhaR NC_011748.1 4480310 4481248 D activates the expression of rhaRS in response to L-rhamnose; transcriptional activator RhaR 4480310..4481248 Escherichia coli 55989 7147394 YP_002405289.1 CDS rhaT NC_011748.1 4481245 4482279 R transports L-rhamnose and L-lyxose into the cell; rhamnose-proton symporter complement(4481245..4482279) Escherichia coli 55989 7147393 YP_002405290.1 CDS sodA NC_011748.1 4482564 4483184 D SodA; manganese binding; only present under aerobic conditions; destroys free radicals; superoxide dismutase 4482564..4483184 Escherichia coli 55989 7147395 YP_002405291.1 CDS kdgT NC_011748.1 4483402 4484376 D transports degraded pectin products into the bacterial cell; 2-keto-3-deoxygluconate permease 4483402..4484376 Escherichia coli 55989 7147671 YP_002405292.1 CDS yiiM NC_011748.1 4484574 4485248 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4484574..4485248 Escherichia coli 55989 7146653 YP_002405293.1 CDS cpxA NC_011748.1 4485354 4486727 R part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors; two-component sensor protein complement(4485354..4486727) Escherichia coli 55989 7149115 YP_002405294.1 CDS cpxR NC_011748.1 4486724 4487422 R response regulator in two-component regulatory system with CpxA; part of the envelope stress response system; DNA-binding transcriptional regulator CpxR complement(4486724..4487422) Escherichia coli 55989 7145748 YP_002405295.1 CDS cpxP NC_011748.1 4487572 4488072 D repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates; repressor CpxP 4487572..4488072 Escherichia coli 55989 7145750 YP_002405296.1 CDS fieF NC_011748.1 4488221 4489123 D member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers; ferrous iron efflux protein F 4488221..4489123 Escherichia coli 55989 7145749 YP_002405297.1 CDS pfkA NC_011748.1 4489304 4490266 D catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis; 6-phosphofructokinase 4489304..4490266 Escherichia coli 55989 7146108 YP_002405298.1 CDS sbp NC_011748.1 4490586 4491575 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91161616, 2002055, 3158524, 8774726, 9298646; Product type t : transporter; sulfate transporter subunit 4490586..4491575 Escherichia coli 55989 7147139 YP_002405299.1 CDS cdh NC_011748.1 4491682 4492437 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86008270, 2995360, 3158524; Product type e : enzyme; CDP-diacylglycerol pyrophosphatase 4491682..4492437 Escherichia coli 55989 7147611 YP_002405300.1 CDS tpiA NC_011748.1 4492492 4493259 R Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate; triosephosphate isomerase complement(4492492..4493259) Escherichia coli 55989 7145684 YP_002405301.1 CDS yiiQ NC_011748.1 4493367 4493966 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4493367..4493966) Escherichia coli 55989 7147830 YP_002405302.1 CDS yiiR NC_011748.1 4494067 4494507 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4494067..4494507 Escherichia coli 55989 7149116 YP_002405303.1 CDS yiiS NC_011748.1 4494719 4495018 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4494719..4495018 Escherichia coli 55989 7149117 YP_002405304.1 CDS yiiT NC_011748.1 4495045 4495473 D with UspC and Usp E is involved in resistance to UV radiation; universal stress protein UspD 4495045..4495473 Escherichia coli 55989 7149118 YP_002405305.1 CDS fpr NC_011748.1 4495478 4496224 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93194782, 94092163, 95050480, 95362685, 1400248, 2834327, 7961651, 8449868, 9149148; Product type e : enzyme; ferredoxin-NADP reductase complement(4495478..4496224) Escherichia coli 55989 7149119 YP_002405306.1 CDS glpX NC_011748.1 4496321 4497331 R type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese; fructose 1,6-bisphosphatase II complement(4496321..4497331) Escherichia coli 55989 7146177 YP_002405307.1 CDS glpK NC_011748.1 4497467 4498975 R Converts glycerol and ADP to glycerol-3-phosphate and ADP; glycerol kinase complement(4497467..4498975) Escherichia coli 55989 7146326 YP_002405308.1 CDS glpF NC_011748.1 4498998 4499843 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12629974, 12948772, 14646142, 15004242, 90094250, 92210584, 11039922, 11101882, 11226336, 11964478, 1372899, 2544860, 6998951; Product type t : transporter; glycerol facilitator complement(4498998..4499843) Escherichia coli 55989 7146322 YP_002405309.1 CDS yiiU NC_011748.1 4500269 4500514 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4500269..4500514 Escherichia coli 55989 7146320 YP_002405310.1 CDS rraA NC_011748.1 4500599 4501084 R regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity; ribonuclease activity regulator protein RraA complement(4500599..4501084) Escherichia coli 55989 7149120 YP_002405311.1 CDS menA NC_011748.1 4501177 4502103 R catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate; 1,4-dihydroxy-2-naphthoate octaprenyltransferase complement(4501177..4502103) Escherichia coli 55989 7147526 YP_002405312.1 CDS hslU NC_011748.1 4502170 4503501 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease ATP-binding subunit HslU complement(4502170..4503501) Escherichia coli 55989 7146817 YP_002405313.1 CDS hslV NC_011748.1 4503511 4504041 R heat shock protein involved in degradation of misfolded proteins; ATP-dependent protease peptidase subunit complement(4503511..4504041) Escherichia coli 55989 7146470 YP_002405314.1 CDS ftsN NC_011748.1 4504134 4505093 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9282742, 93285993, 8509333; Product type cp : cell process; cell division protein FtsN complement(4504134..4505093) Escherichia coli 55989 7146471 YP_002405315.1 CDS cytR NC_011748.1 4505185 4506210 R negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins; DNA-binding transcriptional regulator CytR complement(4505185..4506210) Escherichia coli 55989 7146217 YP_002405316.1 CDS priA NC_011748.1 4506366 4508564 R binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity; primosome assembly protein PriA complement(4506366..4508564) Escherichia coli 55989 7145838 YP_002405317.1 CDS rpmE NC_011748.1 4508767 4508979 D RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome; 50S ribosomal protein L31 4508767..4508979 Escherichia coli 55989 7147244 YP_002405318.1 CDS rhsB NC_011748.1 4509139 4513323 D Evidence 2b : Function of strongly homologous gene; PubMedId : 98361897, 2403547, 2644231, 7934896, 8387990; Product type h : extrachromosomal origin; rhsB element core protein RshB 4509139..4513323 Escherichia coli 55989 7147490 YP_002405319.1 CDS EC55989_4416 NC_011748.1 4513617 4513931 R Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; iso-IS1 InsB protein, transposase complement(4513617..4513931) Escherichia coli 55989 7147401 YP_002405320.1 CDS metJ NC_011748.1 4515221 4515538 R when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis; transcriptional repressor protein MetJ complement(4515221..4515538) Escherichia coli 55989 7149122 YP_002405321.1 CDS metB NC_011748.1 4515815 4516975 D catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine; cystathionine gamma-synthase 4515815..4516975 Escherichia coli 55989 7146832 YP_002405322.1 CDS metL NC_011748.1 4516978 4519410 D multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways; bifunctional aspartate kinase II/homoserine dehydrogenase II 4516978..4519410 Escherichia coli 55989 7146825 YP_002405323.1 CDS metF NC_011748.1 4519759 4520649 D MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor; 5,10-methylenetetrahydrofolate reductase 4519759..4520649 Escherichia coli 55989 7146834 YP_002405324.1 CDS katG NC_011748.1 4520978 4523158 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90292022, 94209230, 3045098; Product type e : enzyme; catalase/hydroperoxidase HPI(I) 4520978..4523158 Escherichia coli 55989 7146828 YP_002405325.1 CDS yijE NC_011748.1 4523252 4524157 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; permease 4523252..4524157 Escherichia coli 55989 7146646 YP_002405326.1 CDS yijF NC_011748.1 4524184 4524801 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4524184..4524801) Escherichia coli 55989 7149124 YP_002405327.1 CDS gldA NC_011748.1 4525076 4526179 R forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone; glycerol dehydrogenase complement(4525076..4526179) Escherichia coli 55989 7149125 YP_002405328.1 CDS fsaB NC_011748.1 4526190 4526852 R similar to transaldolase from Escherichia coli; many organisms have multiple copies; fructose-6-phosphate aldolase complement(4526190..4526852) Escherichia coli 55989 7146291 YP_002405329.1 CDS ptsA NC_011748.1 4526864 4529365 R Evidence 2b : Function of strongly homologous gene; PubMedId : 95291446, 7773398; Product type t : transporter; fused PTS enzymes: Hpr component ; enzyme I component ; enzyme IIA component complement(4526864..4529365) Escherichia coli 55989 7146207 YP_002405330.1 CDS frwC NC_011748.1 4529674 4530753 D FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site; fructose-like permease EIIC subunit 2 4529674..4530753 Escherichia coli 55989 7147285 YP_002405331.1 CDS frwB NC_011748.1 4530768 4531088 D FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS; PTS system fructose-like transporter subunit EIIB 4530768..4531088 Escherichia coli 55989 7146204 YP_002405332.1 CDS pflD NC_011748.1 4531139 4533436 D involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein; formate acetyltransferase 2 4531139..4533436 Escherichia coli 55989 7146203 YP_002405333.1 CDS pflC NC_011748.1 4533402 4534280 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95291446, 14673546, 7773398; Product type e : enzyme; pyruvate formate lyase II activase 4533402..4534280 Escherichia coli 55989 7147144 YP_002405334.1 CDS frwD NC_011748.1 4534282 4534623 D FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog; fructose-like phosphotransferase EIIB subunit 3 4534282..4534623 Escherichia coli 55989 7147143 YP_002405335.1 CDS yijO NC_011748.1 4534610 4535461 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(4534610..4535461) Escherichia coli 55989 7146205 YP_002405336.1 CDS yijP NC_011748.1 4535676 4537409 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 10456927; Product type pm : membrane component; hypothetical protein complement(4535676..4537409) Escherichia coli 55989 7149126 YP_002405337.1 CDS ppc NC_011748.1 4537592 4540243 R catalyzes the formation of oxaloacetate from phosphoenolpyruvate; phosphoenolpyruvate carboxylase complement(4537592..4540243) Escherichia coli 55989 7149127 YP_002405338.1 CDS argE NC_011748.1 4540595 4541746 R catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis; acetylornithine deacetylase complement(4540595..4541746) Escherichia coli 55989 7147221 YP_002405339.1 CDS argC NC_011748.1 4541900 4542904 D catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate; N-acetyl-gamma-glutamyl-phosphate reductase 4541900..4542904 Escherichia coli 55989 7145528 YP_002405340.1 CDS argB NC_011748.1 4542915 4543688 D catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate; acetylglutamate kinase 4542915..4543688 Escherichia coli 55989 7145526 YP_002405341.1 CDS argH NC_011748.1 4543749 4545122 D catalyzes the formation of arginine from (N-L-arginino)succinate; argininosuccinate lyase 4543749..4545122 Escherichia coli 55989 7145525 YP_002405342.1 CDS rspA NC_011748.1 4545620 4546834 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 93341455, 94310441; Product type pe : enzyme; enolase/dehydratase 4545620..4546834 Escherichia coli 55989 7145530 YP_002405343.1 CDS EC55989_4444 NC_011748.1 4546901 4548184 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4546901..4548184 Escherichia coli 55989 7147538 YP_002405344.1 CDS oxyR NC_011748.1 4548435 4549352 D Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA; DNA-binding transcriptional regulator OxyR 4548435..4549352 Escherichia coli 55989 7147089 YP_002405345.1 CDS sthA NC_011748.1 4549335 4550735 R catalyzes the conversion of NADPH to NADH; soluble pyridine nucleotide transhydrogenase complement(4549335..4550735) Escherichia coli 55989 7147088 YP_002405346.1 CDS fabR NC_011748.1 4551012 4551716 D negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis; DNA-binding transcriptional repressor FabR 4551012..4551716 Escherichia coli 55989 7147724 YP_002405347.1 CDS yijD NC_011748.1 4551716 4552075 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein 4551716..4552075 Escherichia coli 55989 7146053 YP_002405348.1 CDS trmA NC_011748.1 4552115 4553215 R catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs; tRNA (uracil-5-)-methyltransferase complement(4552115..4553215) Escherichia coli 55989 7149123 YP_002405349.1 CDS btuB NC_011748.1 4553584 4555428 D involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space; vitamin B12/cobalamin outer membrane transporter 4553584..4555428 Escherichia coli 55989 7145314 YP_002405350.1 CDS murI NC_011748.1 4555373 4556230 D converts L-glutamate to D-glutamate, a component of peptidoglycan; glutamate racemase 4555373..4556230 Escherichia coli 55989 7145639 YP_002405351.1 CDS murB NC_011748.1 4561916 4562944 D catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis; UDP-N-acetylenolpyruvoylglucosamine reductase 4561916..4562944 Escherichia coli 55989 7145293 YP_002405352.1 CDS birA NC_011748.1 4562941 4563906 D catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon; biotin--protein ligase 4562941..4563906 Escherichia coli 55989 7146922 YP_002405353.1 CDS coaA NC_011748.1 4563935 4564885 R catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis; pantothenate kinase complement(4563935..4564885) Escherichia coli 55989 7145631 YP_002405354.1 CDS tufB NC_011748.1 4565803 4566987 D EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu; elongation factor Tu 4565803..4566987 Escherichia coli 55989 7145362 YP_002405355.1 CDS secE NC_011748.1 4567217 4567600 D forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force; preprotein translocase subunit SecE 4567217..4567600 Escherichia coli 55989 7147873 YP_002405356.1 CDS nusG NC_011748.1 4567602 4568147 D Modulates Rho-dependent transcription termination; transcription antitermination protein NusG 4567602..4568147 Escherichia coli 55989 7147623 YP_002405357.1 CDS rplK NC_011748.1 4568306 4568734 D binds directly to 23S ribosomal RNA; 50S ribosomal protein L11 4568306..4568734 Escherichia coli 55989 7147060 YP_002405358.1 CDS rplA NC_011748.1 4568738 4569442 D in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA; 50S ribosomal protein L1 4568738..4569442 Escherichia coli 55989 7147471 YP_002405359.1 CDS rplJ NC_011748.1 4569855 4570352 D binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit; 50S ribosomal protein L10 4569855..4570352 Escherichia coli 55989 7147463 YP_002405360.1 CDS rplL NC_011748.1 4570419 4570784 D present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors; 50S ribosomal protein L7/L12 4570419..4570784 Escherichia coli 55989 7147470 YP_002405361.1 CDS rpoB NC_011748.1 4571104 4575132 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme; DNA-directed RNA polymerase subunit beta 4571104..4575132 Escherichia coli 55989 7147472 YP_002405362.1 CDS rpoC NC_011748.1 4575209 4579432 D DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter; DNA-directed RNA polymerase subunit beta' 4575209..4579432 Escherichia coli 55989 7147496 YP_002405363.1 CDS htrC NC_011748.1 4579645 4580184 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264341, 92021792, 2160943; Product type f : factor; heat shock protein 4579645..4580184 Escherichia coli 55989 7147497 YP_002405364.1 CDS thiH NC_011748.1 4580594 4581727 R in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center; thiamine biosynthesis protein ThiH complement(4580594..4581727) Escherichia coli 55989 7147709 YP_002405365.1 CDS thiG NC_011748.1 4581724 4582494 R functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate; thiazole synthase complement(4581724..4582494) Escherichia coli 55989 7147787 YP_002405366.1 CDS thiS NC_011748.1 4582496 4582696 R with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate; sulfur carrier protein ThiS complement(4582496..4582696) Escherichia coli 55989 7147786 YP_002405367.1 CDS thiF NC_011748.1 4582680 4583435 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8432721, 94089392, 98298179, 10082377, 9632726; Product type e : enzyme; thiamin (thiazole moiety) biosynthesis protein complement(4582680..4583435) Escherichia coli 55989 7147793 YP_002405368.1 CDS thiE NC_011748.1 4583428 4584063 R catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate; thiamine-phosphate pyrophosphorylase complement(4583428..4584063) Escherichia coli 55989 7147785 YP_002405369.1 CDS thiC NC_011748.1 4584063 4585958 R required for the synthesis of the hydromethylpyrimidine moiety of thiamine; thiamine biosynthesis protein ThiC complement(4584063..4585958) Escherichia coli 55989 7147784 YP_002405370.1 CDS rsd NC_011748.1 4586191 4586667 R binds specifically to the major sigma factor sigma 70; active in stationary phase; anti-RNA polymerase sigma 70 factor complement(4586191..4586667) Escherichia coli 55989 7145315 YP_002405371.1 CDS nudC NC_011748.1 4586762 4587535 D can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates; NADH pyrophosphatase 4586762..4587535 Escherichia coli 55989 7147529 YP_002405372.1 CDS hemE NC_011748.1 4587575 4588639 D catalyzes the formation of coproporphyrinogen from uroporphyrinogen III; uroporphyrinogen decarboxylase 4587575..4588639 Escherichia coli 55989 7147037 YP_002405373.1 CDS nfi NC_011748.1 4588649 4589320 D Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures; endonuclease V 4588649..4589320 Escherichia coli 55989 7146411 YP_002405374.1 CDS yjaG NC_011748.1 4589363 4589953 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4589363..4589953 Escherichia coli 55989 7146985 YP_002405375.1 CDS hupA NC_011748.1 4590140 4590412 D histone-like DNA-binding protein; transcriptional regulator HU subunit alpha 4590140..4590412 Escherichia coli 55989 7149129 YP_002405376.1 CDS yjaH NC_011748.1 4590425 4591120 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4590425..4591120 Escherichia coli 55989 7146480 YP_002405377.1 CDS zraP NC_011748.1 4591122 4591547 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98362023, 9694902; Product type pf : factor; zinc resistance protein complement(4591122..4591547) Escherichia coli 55989 7149130 YP_002405378.1 CDS zraS NC_011748.1 4591785 4593161 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21140164, 89327164, 92255260, 11243806, 2666400; Product type r : regulator; sensor protein ZraS 4591785..4593161 Escherichia coli 55989 7149495 YP_002405379.1 CDS zraR NC_011748.1 4593158 4594483 D DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein; transcriptional regulatory protein ZraR 4593158..4594483 Escherichia coli 55989 7149497 YP_002405380.1 CDS purD NC_011748.1 4594480 4595769 R catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis; phosphoribosylamine--glycine ligase complement(4594480..4595769) Escherichia coli 55989 7149496 YP_002405381.1 CDS purH NC_011748.1 4595781 4597370 R involved in de novo purine biosynthesis; bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase complement(4595781..4597370) Escherichia coli 55989 7147295 YP_002405382.1 CDS yjaB NC_011748.1 4603112 4603555 R Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; hypothetical protein complement(4603112..4603555) Escherichia coli 55989 7145294 YP_002405383.1 CDS metA NC_011748.1 4603712 4604641 D catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis; homoserine O-succinyltransferase 4603712..4604641 Escherichia coli 55989 7149128 YP_002405384.1 CDS aceB NC_011748.1 4604910 4606511 D Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle; malate synthase 4604910..4606511 Escherichia coli 55989 7146824 YP_002405385.1 CDS aceA NC_011748.1 4606541 4607845 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91295197, 92112731, 92353108, 2836370, 3049537, 3060852, 3276689, 3290857, 3291954, 7826335; Product type e : enzyme; isocitrate lyase 4606541..4607845 Escherichia coli 55989 7145433 YP_002405386.1 CDS aceK NC_011748.1 4608126 4609862 D catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol; bifunctional isocitrate dehydrogenase kinase/phosphatase protein 4608126..4609862 Escherichia coli 55989 7145432 YP_002405387.1 CDS iclR NC_011748.1 4611722 4612546 R regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase; IclR family transcriptional regulator complement(4611722..4612546) Escherichia coli 55989 7145551 YP_002405388.1 CDS metH NC_011748.1 4612746 4616429 D one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity; B12-dependent methionine synthase 4612746..4616429 Escherichia coli 55989 7146538 YP_002405389.1 CDS yjbB NC_011748.1 4616649 4618280 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4616649..4618280 Escherichia coli 55989 7146830 YP_002405390.1 CDS pepE NC_011748.1 4618371 4619060 R alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family; peptidase E complement(4618371..4619060) Escherichia coli 55989 7149132 YP_002405391.1 CDS yjbC NC_011748.1 4619272 4620144 D catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA; 23S rRNA pseudouridine synthase F 4619272..4620144 Escherichia coli 55989 7147133 YP_002405392.1 CDS yjbD NC_011748.1 4620145 4620417 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4620145..4620417) Escherichia coli 55989 7149133 YP_002405393.1 CDS EC55989_4509 NC_011748.1 4620946 4622073 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4620946..4622073 Escherichia coli 55989 7149134 YP_002405394.1 CDS EC55989_4510 NC_011748.1 4622070 4622870 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4622070..4622870 Escherichia coli 55989 7145097 YP_002405395.1 CDS EC55989_4511 NC_011748.1 4622906 4623838 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pf : factor; zeta toxin; poison-antidote element complement(4622906..4623838) Escherichia coli 55989 7145098 YP_002405396.1 CDS lysC NC_011748.1 4623977 4625326 R catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive; aspartate kinase complement(4623977..4625326) Escherichia coli 55989 7145099 YP_002405397.1 CDS pgi NC_011748.1 4625851 4627500 D functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family; glucose-6-phosphate isomerase 4625851..4627500 Escherichia coli 55989 7145316 YP_002405398.1 CDS EC55989_4514 NC_011748.1 4627836 4628084 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4627836..4628084) Escherichia coli 55989 7147150 YP_002405399.1 CDS yjbF NC_011748.1 4628211 4628849 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type lp : lipoprotein; lipoprotein 4628211..4628849 Escherichia coli 55989 7145100 YP_002405400.1 CDS yjbG NC_011748.1 4628846 4629583 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4628846..4629583 Escherichia coli 55989 7149135 YP_002405401.1 CDS yjbH NC_011748.1 4629583 4631679 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; porin 4629583..4631679 Escherichia coli 55989 7149136 YP_002405402.1 CDS EC55989_4518 NC_011748.1 4631683 4631844 D Evidence 6 : Doubtful CDS; hypothetical protein 4631683..4631844 Escherichia coli 55989 7149137 YP_002405403.1 CDS EC55989_4519 NC_011748.1 4631726 4632004 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4631726..4632004) Escherichia coli 55989 7145101 YP_002405404.1 CDS yjbA NC_011748.1 4632274 4632684 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10986267; Product type pm : membrane component; phosphate-starvation-inducible protein PsiE 4632274..4632684 Escherichia coli 55989 7145102 YP_002405405.1 CDS xylE NC_011748.1 4632728 4634203 R xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter; D-xylose transporter XylE complement(4632728..4634203) Escherichia coli 55989 7149131 YP_002405406.1 CDS malG NC_011748.1 4634575 4635465 R with MalKFE is involved in the transport of maltose into the cell; maltose transporter permease complement(4634575..4635465) Escherichia coli 55989 7147997 YP_002405407.1 CDS malF NC_011748.1 4635480 4637024 R with MalKGE is involved in maltose transport into the cell; maltose transporter membrane protein complement(4635480..4637024) Escherichia coli 55989 7146770 YP_002405408.1 CDS malE NC_011748.1 4637178 4638368 R functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis; maltose ABC transporter periplasmic protein complement(4637178..4638368) Escherichia coli 55989 7146769 YP_002405409.1 CDS malK NC_011748.1 4638733 4639848 D with malEFG is involved in import of maltose/maltodextrin; maltose/maltodextrin transporter ATP-binding protein 4638733..4639848 Escherichia coli 55989 7146768 YP_002405410.1 CDS lamB NC_011748.1 4639920 4641260 D porin involved in the transport of maltose and maltodextrins; maltoporin 4639920..4641260 Escherichia coli 55989 7146772 YP_002405411.1 CDS malM NC_011748.1 4641412 4642332 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87141162, 2434655, 6086106; Product type pt : transporter; maltose regulon periplasmic protein 4641412..4642332 Escherichia coli 55989 7146679 YP_002405412.1 CDS EC55989_4529 NC_011748.1 4642561 4642755 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4642561..4642755 Escherichia coli 55989 7146773 YP_002405413.1 CDS yjbI NC_011748.1 4642813 4644141 D in E. coli, some yjbl mutations have been reported as suppressors of dnaG mutations; hypothetical protein 4642813..4644141 Escherichia coli 55989 7145103 YP_002405414.1 CDS ubiC NC_011748.1 4644364 4644861 D catalyzes the formation of 4-hydroxybenzoate from chorismate; chorismate pyruvate lyase 4644364..4644861 Escherichia coli 55989 7149138 YP_002405415.1 CDS ubiA NC_011748.1 4644874 4645746 D catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway; 4-hydroxybenzoate octaprenyltransferase 4644874..4645746 Escherichia coli 55989 7147889 YP_002405416.1 CDS plsB NC_011748.1 4645901 4648324 R PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA; glycerol-3-phosphate acyltransferase complement(4645901..4648324) Escherichia coli 55989 7147887 YP_002405417.1 CDS dgkA NC_011748.1 4648495 4648863 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10220339, 6257698, 86278195, 88111690, 2984194, 6309817, 8071224; Product type e : enzyme; diacylglycerol kinase 4648495..4648863 Escherichia coli 55989 7147195 YP_002405418.1 CDS lexA NC_011748.1 4648973 4649581 D Represses a number of genes involved in the response to DNA damage; LexA repressor 4648973..4649581 Escherichia coli 55989 7145894 YP_002405419.1 CDS dinF NC_011748.1 4649600 4651000 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87165788; Product type cp : cell process; DNA-damage-inducible SOS response protein 4649600..4651000 Escherichia coli 55989 7146696 YP_002405420.1 CDS yjbJ NC_011748.1 4651096 4651305 D unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential; stress-response protein 4651096..4651305 Escherichia coli 55989 7145916 YP_002405421.1 CDS zur NC_011748.1 4651347 4651862 R Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB; zinc uptake transcriptional repressor complement(4651347..4651862) Escherichia coli 55989 7149139 YP_002405422.1 CDS yjbL NC_011748.1 4652180 4652434 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4652180..4652434 Escherichia coli 55989 7149499 YP_002405423.1 CDS yjbM NC_011748.1 4652425 4653171 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4652425..4653171 Escherichia coli 55989 7149140 YP_002405424.1 CDS yjbN NC_011748.1 4653535 4654572 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 22095566; Product type e : enzyme; tRNA-dihydrouridine synthase A 4653535..4654572 Escherichia coli 55989 7149141 YP_002405425.1 CDS pspG NC_011748.1 4654496 4654948 D coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia; phage shock protein G 4654496..4654948 Escherichia coli 55989 7149142 YP_002405426.1 CDS qor NC_011748.1 4655114 4656097 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94089392, 7602590; Product type e : enzyme; quinone oxidoreductase complement(4655114..4656097) Escherichia coli 55989 7149143 YP_002405427.1 CDS dnaB NC_011748.1 4656180 4657595 D unwinds double stranded DNA; replicative DNA helicase 4656180..4657595 Escherichia coli 55989 7147328 YP_002405428.1 CDS alr NC_011748.1 4657648 4658727 D converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer; alanine racemase 4657648..4658727 Escherichia coli 55989 7145933 YP_002405429.1 CDS tyrB NC_011748.1 4658980 4660173 D catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate; aromatic amino acid aminotransferase 4658980..4660173 Escherichia coli 55989 7145488 YP_002405430.1 CDS EC55989_4548 NC_011748.1 4660395 4660937 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4660395..4660937) Escherichia coli 55989 7147882 YP_002405431.1 CDS aphA NC_011748.1 4661300 4662013 D Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity; acid phosphatase/phosphotransferase 4661300..4662013 Escherichia coli 55989 7145104 YP_002405432.1 CDS yjbQ NC_011748.1 4662124 4662540 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11972052; hypothetical protein 4662124..4662540 Escherichia coli 55989 7145507 YP_002405433.1 CDS yjbR NC_011748.1 4662544 4662900 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4662544..4662900 Escherichia coli 55989 7149144 YP_002405434.1 CDS uvrA NC_011748.1 4662935 4665757 R The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate; excinuclease ABC subunit A complement(4662935..4665757) Escherichia coli 55989 7149145 YP_002405435.1 CDS ssb NC_011748.1 4666011 4666547 D binds to single stranded DNA and PriA helcase facilitate replication restart; single-stranded DNA-binding protein 4666011..4666547 Escherichia coli 55989 7147933 YP_002405436.1 CDS yjcB NC_011748.1 4666646 4666927 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(4666646..4666927) Escherichia coli 55989 7147710 YP_002405437.1 CDS yjcC NC_011748.1 4667357 4668943 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; signal transduction protein (EAL domain containing protein) 4667357..4668943 Escherichia coli 55989 7149146 YP_002405438.1 CDS soxS NC_011748.1 4668946 4669269 R regulates genes involved in response to oxidative stress; DNA-binding transcriptional regulator SoxS complement(4668946..4669269) Escherichia coli 55989 7149147 YP_002405439.1 CDS soxR NC_011748.1 4669355 4669819 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91210176, 91360349, 94139656, 9564045, 10207625, 12670967, 1653416, 1708380, 7673113, 8065907, 8306957, 8631739, 8969171, 9019397, 9092651, 9204707; Product type r : regulator; DNA-binding transcriptional dual regulator, Fe-S center for redox-sensing 4669355..4669819 Escherichia coli 55989 7147680 YP_002405440.1 CDS yjcD NC_011748.1 4670365 4671714 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; permease 4670365..4671714 Escherichia coli 55989 7147594 YP_002405441.1 CDS yjcE NC_011748.1 4671865 4673514 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 21557160, 11479290; Product type pt : transporter; cation/proton antiporter 4671865..4673514 Escherichia coli 55989 7149148 YP_002405442.1 CDS yjcF NC_011748.1 4673668 4674960 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4673668..4674960) Escherichia coli 55989 7149149 YP_002405443.1 CDS actP NC_011748.1 4675138 4676787 R member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake; acetate permease complement(4675138..4676787) Escherichia coli 55989 7149150 YP_002405444.1 CDS yjcH NC_011748.1 4676784 4677098 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 14563880; Product type pm : membrane component; hypothetical protein complement(4676784..4677098) Escherichia coli 55989 7145451 YP_002405445.1 CDS acs NC_011748.1 4677298 4679256 R Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA; acetyl-CoA synthetase complement(4677298..4679256) Escherichia coli 55989 7149151 YP_002405446.1 CDS nrfA NC_011748.1 4679648 4681084 D catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552; cytochrome c552 4679648..4681084 Escherichia coli 55989 7145450 YP_002405447.1 CDS nrfB NC_011748.1 4681129 4681695 D part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia; cytochrome c nitrite reductase pentaheme subunit 4681129..4681695 Escherichia coli 55989 7147027 YP_002405448.1 CDS nrfC NC_011748.1 4681692 4682363 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94335626, 8057835; Product type c : carrier; formate-dependent nitrite reductase, 4Fe4S subunit 4681692..4682363 Escherichia coli 55989 7147028 YP_002405449.1 CDS nrfD NC_011748.1 4682360 4683316 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 8057835; Product type e : enzyme; formate-dependent nitrite reductase, membrane subunit 4682360..4683316 Escherichia coli 55989 7147029 YP_002405450.1 CDS nrfE NC_011748.1 4683396 4685054 D with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552; heme lyase subunit NrfE 4683396..4685054 Escherichia coli 55989 7147030 YP_002405451.1 CDS nrfF NC_011748.1 4685047 4685430 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfF 4685047..4685430 Escherichia coli 55989 7147031 YP_002405452.1 CDS nrfG NC_011748.1 4685427 4686023 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91058381, 94335626, 9593308, 8057835, 8842153; Product type f : factor; formate-dependent nitrite reductase complex subunit NrfG 4685427..4686023 Escherichia coli 55989 7147032 YP_002405453.1 CDS gltP NC_011748.1 4686365 4687678 D carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system; glutamate/aspartate:proton symporter 4686365..4687678 Escherichia coli 55989 7147033 YP_002405454.1 CDS yjcO NC_011748.1 4687756 4688445 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4687756..4688445) Escherichia coli 55989 7146334 YP_002405455.1 CDS fdhF NC_011748.1 4688539 4690686 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type e : enzyme; formate dehydrogenase-H, selenopolypeptide subunit complement(4688539..4690686) Escherichia coli 55989 7149152 YP_002405456.1 CDS yjcP NC_011748.1 4690884 4692350 R part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family; outer membrane efflux protein MdtP complement(4690884..4692350) Escherichia coli 55989 7146068 YP_002405457.1 CDS yjcQ NC_011748.1 4692347 4694398 R possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug efflux system protein MdtO complement(4692347..4694398) Escherichia coli 55989 7149153 YP_002405458.1 CDS yjcR NC_011748.1 4694398 4695429 R with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride; multidrug resistance protein MdtN complement(4694398..4695429) Escherichia coli 55989 7149154 YP_002405459.1 CDS yjcS NC_011748.1 4695932 4697917 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1587481; Product type pe : enzyme; alkyl sulfatase complement(4695932..4697917) Escherichia coli 55989 7149155 YP_002405460.1 CDS EC55989_4580 NC_011748.1 4698170 4698487 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; ribose-5-phosphate isomerase B (rpiB-like) 4698170..4698487 Escherichia coli 55989 7149156 YP_002405461.1 CDS yjdP NC_011748.1 4698556 4698885 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4698556..4698885 Escherichia coli 55989 7145105 YP_002405462.1 CDS phnP NC_011748.1 4699032 4699790 R required for the use of phosphonates and phosphite as phosphorus sources; carbon-phosphorus lyase complex accessory protein complement(4699032..4699790) Escherichia coli 55989 7149166 YP_002405463.1 CDS phnO NC_011748.1 4699792 4700226 R PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role; aminoalkylphosphonic acid N-acetyltransferase complement(4699792..4700226) Escherichia coli 55989 7147177 YP_002405464.1 CDS phnN NC_011748.1 4700213 4700770 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12700258, 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; ribose 1,5-bisphosphokinase complement(4700213..4700770) Escherichia coli 55989 7147176 YP_002405465.1 CDS phnM NC_011748.1 4700770 4701906 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 91100346, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4700770..4701906) Escherichia coli 55989 7147175 YP_002405466.1 CDS phnL NC_011748.1 4701903 4702583 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4701903..4702583) Escherichia coli 55989 7147174 YP_002405467.1 CDS phnK NC_011748.1 4702760 4703518 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; phosphonate C-P lyase system protein PhnK complement(4702760..4703518) Escherichia coli 55989 7147173 YP_002405468.1 CDS phnJ NC_011748.1 4703515 4704360 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4703515..4704360) Escherichia coli 55989 7147172 YP_002405469.1 CDS phnI NC_011748.1 4704353 4705417 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4704353..4705417) Escherichia coli 55989 7147171 YP_002405470.1 CDS phnH NC_011748.1 4705417 4706001 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4705417..4706001) Escherichia coli 55989 7147170 YP_002405471.1 CDS phnG NC_011748.1 4705998 4706450 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type e : enzyme; carbon-phosphorus lyase complex subunit complement(4705998..4706450) Escherichia coli 55989 7147169 YP_002405472.1 CDS phnF NC_011748.1 4706451 4707176 R may be involved in phosphonate uptake and biodegradation; phosphonate metabolism transcriptional regulator PhnF complement(4706451..4707176) Escherichia coli 55989 7147168 YP_002405473.1 CDS phnE NC_011748.1 4707197 4708039 R Evidence 2b : Function of strongly homologous gene; Product type t : transporter; phosphonates transport system, permease protein complement(4707197..4708039) Escherichia coli 55989 7147167 YP_002405474.1 CDS phnD NC_011748.1 4708082 4709098 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester transporter subunit ; periplasmic binding component of ABC superfamily complement(4708082..4709098) Escherichia coli 55989 7147166 YP_002405475.1 CDS phnC NC_011748.1 4709123 4709911 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93122525, 93273711, 93328121, 9650256, 1840580, 2155230; Product type t : transporter; phosphonate/organophosphate ester transporter subunit complement(4709123..4709911) Escherichia coli 55989 7147165 YP_002405476.1 CDS phnB NC_011748.1 4710044 4710487 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 93328121, 9650256, 2155230; hypothetical protein complement(4710044..4710487) Escherichia coli 55989 7147164 YP_002405477.1 CDS EC55989_4598 NC_011748.1 4710647 4711129 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9650256, 2155230; Product type pt : transporter; alkylphosphonate uptake protein in phosphonate metabolism complement(4710647..4711129) Escherichia coli 55989 7147163 YP_002405478.1 CDS yjdA NC_011748.1 4711384 4713612 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4711384..4713612 Escherichia coli 55989 7145106 YP_002405479.1 CDS yjcZ NC_011748.1 4713609 4714487 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4713609..4714487 Escherichia coli 55989 7149158 YP_002405480.1 CDS proP NC_011748.1 4714751 4716253 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 10049386, 12525168, 92165733, 93132799, 9871325, 99376621, 8421314; Product type t : transporter; proline/glycine betaine transporter 4714751..4716253 Escherichia coli 55989 7149157 YP_002405481.1 CDS basS NC_011748.1 4716430 4717521 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 94110256, 8282725; Product type r : regulator; sensor protein BasS/PmrB complement(4716430..4717521) Escherichia coli 55989 7147255 YP_002405482.1 CDS basR NC_011748.1 4717531 4718199 R response regulator in two-component regulatory system with BasS; DNA-binding transcriptional regulator BasR complement(4717531..4718199) Escherichia coli 55989 7145598 YP_002405483.1 CDS eptA NC_011748.1 4718196 4719839 R with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division; cell division protein complement(4718196..4719839) Escherichia coli 55989 7145597 YP_002405484.1 CDS adiC NC_011748.1 4719943 4721280 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12867448; Product type t : transporter; arginine:agmatin antiporter complement(4719943..4721280) Escherichia coli 55989 7146018 YP_002405485.1 CDS adiY NC_011748.1 4721417 4722178 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : c; Product type r : regulator; DNA-binding transcriptional activator complement(4721417..4722178) Escherichia coli 55989 7145458 YP_002405486.1 CDS adiA NC_011748.1 4722503 4724773 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 93186686, 2830169, 4204273, 8383109; Product type e : enzyme; biodegradative arginine decarboxylase complement(4722503..4724773) Escherichia coli 55989 7145459 YP_002405487.1 CDS melR NC_011748.1 4724969 4725877 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90060832, 9108148, 1445207, 2684786, 2830169; Product type r : regulator; DNA-binding transcriptional regulator MelR complement(4724969..4725877) Escherichia coli 55989 7145457 YP_002405488.1 CDS melA NC_011748.1 4726160 4727515 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87174747, 88162811, 90248411, 2831880, 3031590, 6329200; Product type e : enzyme; alpha-galactosidase 4726160..4727515 Escherichia coli 55989 7146816 YP_002405489.1 CDS melB NC_011748.1 4727630 4729039 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14757226, 90241878, 92297631, 93155159, 1730719, 1872836, 6323466, 8672452; Product type t : transporter; melibiose:sodium symporter 4727630..4729039 Escherichia coli 55989 7146814 YP_002405490.1 CDS yjdF NC_011748.1 4729178 4729807 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(4729178..4729807) Escherichia coli 55989 7146815 YP_002405491.1 CDS fumB NC_011748.1 4729930 4731576 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 86142617, 88193096, 89255123, 2656658; Product type e : enzyme; anaerobic class I fumarate hydratase complement(4729930..4731576) Escherichia coli 55989 7149160 YP_002405492.1 CDS dcuB NC_011748.1 4731654 4732994 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters; anaerobic C4-dicarboxylate transporter complement(4731654..4732994) Escherichia coli 55989 7146231 YP_002405493.1 CDS dcuR NC_011748.1 4733565 4734284 R response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration; DNA-binding transcriptional activator DcuR complement(4733565..4734284) Escherichia coli 55989 7145861 YP_002405494.1 CDS dcuS NC_011748.1 4734281 4735912 R C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration; sensory histidine kinase DcuS complement(4734281..4735912) Escherichia coli 55989 7145864 YP_002405495.1 CDS yjdI NC_011748.1 4736093 4736323 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4736093..4736323 Escherichia coli 55989 7145865 YP_002405496.1 CDS yjdJ NC_011748.1 4736335 4736607 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acyltransferase with acyl-CoA N-acyltransferase domain 4736335..4736607 Escherichia coli 55989 7149161 YP_002405497.1 CDS yjdK NC_011748.1 4736834 4737130 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4736834..4737130 Escherichia coli 55989 7149162 YP_002405498.1 CDS yjdO NC_011748.1 4737158 4737331 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4737158..4737331 Escherichia coli 55989 7149163 YP_002405499.1 CDS lysU NC_011748.1 4737450 4738967 R class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1; lysyl-tRNA synthetase complement(4737450..4738967) Escherichia coli 55989 7149165 YP_002405500.1 CDS yjdL NC_011748.1 4739204 4740661 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter complement(4739204..4740661) Escherichia coli 55989 7146760 YP_002405501.1 CDS cadA NC_011748.1 4740720 4742867 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92105022, 92210511, 1370290, 1556085, 4204273; Product type e : enzyme; lysine decarboxylase 1 complement(4740720..4742867) Escherichia coli 55989 7149164 YP_002405502.1 CDS cadB NC_011748.1 4742947 4744281 R antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein; lysine/cadaverine antiporter complement(4742947..4744281) Escherichia coli 55989 7145653 YP_002405503.1 CDS cadC NC_011748.1 4744647 4746185 R regulates the cadBA operon; DNA-binding transcriptional activator CadC complement(4744647..4746185) Escherichia coli 55989 7145654 YP_002405504.1 CDS EC55989_4627 NC_011748.1 4746472 4746690 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4746472..4746690 Escherichia coli 55989 7145655 YP_002405505.1 CDS EC55989_4628 NC_011748.1 4746934 4747776 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 9987116; hypothetical protein complement(4746934..4747776) Escherichia coli 55989 7145107 YP_002405506.1 CDS EC55989_4629 NC_011748.1 4747861 4748295 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4747861..4748295) Escherichia coli 55989 7145108 YP_002405507.1 CDS yeeW NC_011748.1 4748078 4748566 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4748078..4748566) Escherichia coli 55989 7145109 YP_002405508.1 CDS yeeV NC_011748.1 4748563 4749045 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type f : factor; toxin of the YeeV-YeeU toxin-antitoxin system complement(4748563..4749045) Escherichia coli 55989 7148621 YP_002405509.1 CDS yeeU NC_011748.1 4748987 4749364 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; antitoxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage complement(4748987..4749364) Escherichia coli 55989 7148618 YP_002405510.1 CDS yeeT NC_011748.1 4749444 4749665 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; CP4-44 prophage complement(4749444..4749665) Escherichia coli 55989 7148614 YP_002405511.1 CDS yeeS NC_011748.1 4749752 4750198 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : factor; DNA repair protein; CP4-44 prophage complement(4749752..4750198) Escherichia coli 55989 7148610 YP_002405512.1 CDS EC55989_4636 NC_011748.1 4750244 4751098 R Evidence 4 : Homologs of previously reported genes of unknown function; antirestriction protein complement(4750244..4751098) Escherichia coli 55989 7148606 YP_002405513.1 CDS EC55989_4637 NC_011748.1 4751241 4751567 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 4751241..4751567 Escherichia coli 55989 7145110 YP_002405514.1 CDS EC55989_4638 NC_011748.1 4751564 4752046 D Evidence 7 : Gene remnant; Product type pe : enzyme; transposase ORF B (fragment), IS629 4751564..4752046 Escherichia coli 55989 7145111 YP_002405515.1 CDS EC55989_4639 NC_011748.1 4752638 4754161 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; reverse transcriptase-like protein from prophage or plasmid 4752638..4754161 Escherichia coli 55989 7145112 YP_002405516.1 CDS iutA NC_011748.1 4755126 4757405 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 4313071, 6456229, 7044820, 7042696, 6749806; Product type rc : receptor; Ferric aerobactin receptor precursor complement(4755126..4757405) Escherichia coli 55989 7145114 YP_002405517.1 CDS iucD NC_011748.1 4757327 4758664 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3275632, 10064136; Product type e : enzyme; L-lysine 6-monooxygenase (Lysine N(6)-hydroxylase) complement(4757327..4758664) Escherichia coli 55989 7146641 YP_002405518.1 CDS iucC NC_011748.1 4758661 4760403 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; Aerobactin siderophore biosynthesis protein complement(4758661..4760403) Escherichia coli 55989 7146640 YP_002405519.1 CDS iucB NC_011748.1 4760403 4761350 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; aerobactin siderophore biosynthesis protein, N(6)-hydroxylysine acetylase complement(4760403..4761350) Escherichia coli 55989 7146639 YP_002405520.1 CDS iucA NC_011748.1 4761351 4763138 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 3087960; Product type e : enzyme; aerobactin siderophore biosynthesis protein complement(4761351..4763138) Escherichia coli 55989 7146638 YP_002405521.1 CDS shiF NC_011748.1 4763211 4764404 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 10411725; Product type pt : transporter; membrane transport protein, major facilitator superfamily 4763211..4764404 Escherichia coli 55989 7146637 YP_002405522.1 CDS EC55989_4647 NC_011748.1 4764354 4765280 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4764354..4765280) Escherichia coli 55989 7147654 YP_002405523.1 CDS EC55989_4648 NC_011748.1 4765587 4765784 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4765587..4765784 Escherichia coli 55989 7145115 YP_002405524.1 CDS EC55989_4649 NC_011748.1 4765771 4765956 R Evidence 7 : Gene remnant; Product type pe : enzyme; Transposase ORF D (fragment), ISEc8 complement(4765771..4765956) Escherichia coli 55989 7145116 YP_002405525.1 CDS EC55989_4650 NC_011748.1 4766020 4767153 D Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase, IS110 family 4766020..4767153 Escherichia coli 55989 7145117 YP_002405526.1 CDS EC55989_4652 NC_011748.1 4767765 4769288 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; reverse transcriptase-like protein from prophage or plasmid complement(4767765..4769288) Escherichia coli 55989 7145296 YP_002405527.1 CDS EC55989_4653 NC_011748.1 4769880 4770362 R Evidence 7 : Gene remnant; Product type pe : enzyme; transposase ORF B (fragment), IS629 complement(4769880..4770362) Escherichia coli 55989 7145120 YP_002405528.1 CDS EC55989_4654 NC_011748.1 4770359 4770685 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 complement(4770359..4770685) Escherichia coli 55989 7145121 YP_002405529.1 CDS EC55989_4656 NC_011748.1 4771263 4772387 R transposase complement(4771263..4772387) Escherichia coli 55989 7145123 YP_002405530.1 CDS EC55989_4657 NC_011748.1 4772454 4772615 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4772454..4772615) Escherichia coli 55989 7145124 YP_002405531.1 CDS EC55989_4659 NC_011748.1 4773180 4773398 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4773180..4773398 Escherichia coli 55989 7145126 YP_002405532.1 CDS EC55989_4660 NC_011748.1 4773549 4777667 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; Serine protease pic precursor (ShMu) complement(4773549..4777667) Escherichia coli 55989 7145127 YP_002405533.1 CDS EC55989_4662 NC_011748.1 4778395 4779918 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; reverse transcriptase-like protein from prophage or plasmid complement(4778395..4779918) Escherichia coli 55989 7145297 YP_002405534.1 CDS EC55989_4663 NC_011748.1 4780510 4780992 R Evidence 7 : Gene remnant; Product type pe : enzyme; transposase ORF B (fragment), IS629 complement(4780510..4780992) Escherichia coli 55989 7145130 YP_002405535.1 CDS EC55989_4664 NC_011748.1 4780989 4781315 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 complement(4780989..4781315) Escherichia coli 55989 7145131 YP_002405536.1 CDS EC55989_4665 NC_011748.1 4781960 4782124 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4781960..4782124) Escherichia coli 55989 7145132 YP_002405537.1 CDS EC55989_4669 NC_011748.1 4784434 4786524 D IrgA-homologue adhesin (Iha); TonB-dependent; acts as a specific receptor of enterobactin; fur-regulated; urovirulence factor; bifunctional enterobactin receptor/adhesin protein 4784434..4786524 Escherichia coli 55989 7145136 YP_002405538.1 CDS EC55989_4670 NC_011748.1 4786758 4786982 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4786758..4786982 Escherichia coli 55989 7145137 YP_002405539.1 CDS EC55989_4671 NC_011748.1 4787129 4788742 R Evidence 4 : Homologs of previously reported genes of unknown function; transposase ORF1, IS66 family complement(4787129..4788742) Escherichia coli 55989 7145138 YP_002405540.1 CDS EC55989_4672 NC_011748.1 4788948 4789274 D Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase ORF A, IS629 4788948..4789274 Escherichia coli 55989 7145139 YP_002405541.1 CDS EC55989_4673 NC_011748.1 4789271 4789753 D Evidence 7 : Gene remnant; Product type pe : enzyme; transposase ORF B (fragment), IS629 4789271..4789753 Escherichia coli 55989 7145140 YP_002405542.1 CDS EC55989_4674 NC_011748.1 4790345 4791868 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; reverse transcriptase-like protein from prophage or plasmid 4790345..4791868 Escherichia coli 55989 7145141 YP_002405543.1 CDS EC55989_4677 NC_011748.1 4792703 4793128 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; transposase OrfA from plasmid origin complement(4792703..4793128) Escherichia coli 55989 7145144 YP_002405544.1 CDS EC55989_4678 NC_011748.1 4793356 4794270 R Evidence 7 : Gene remnant; transposase (fragment) complement(4793356..4794270) Escherichia coli 55989 7145145 YP_002405545.1 CDS EC55989_4679 NC_011748.1 4794357 4795040 R Evidence 7 : Gene remnant; transposase (fragment) complement(4794357..4795040) Escherichia coli 55989 7145146 YP_002405546.1 CDS EC55989_4681 NC_011748.1 4795739 4796488 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4795739..4796488) Escherichia coli 55989 7145148 YP_002405547.1 CDS EC55989_4682 NC_011748.1 4796367 4800224 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; Product type e : enzyme; Serine protease pet precursor (Plasmid-encoded toxin pet) complement(4796367..4800224) Escherichia coli 55989 7145149 YP_002405548.1 CDS EC55989_4686 NC_011748.1 4802695 4806210 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; superfamily I DNA helicase complement(4802695..4806210) Escherichia coli 55989 7145152 YP_002405549.1 CDS EC55989_4687 NC_011748.1 4806299 4806562 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4806299..4806562 Escherichia coli 55989 7145153 YP_002405550.1 CDS int NC_011748.1 4806663 4807925 R Evidence 2b : Function of strongly homologous gene; Product type h : extrachromosomal origin; Prophage integrase complement(4806663..4807925) Escherichia coli 55989 7145154 YP_002405551.1 CDS EC55989_4689 NC_011748.1 4807989 4808237 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4807989..4808237) Escherichia coli 55989 7146606 YP_002405552.1 CDS yjdC NC_011748.1 4808305 4808880 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 1370290; Product type pr : regulator; transcriptional regulator complement(4808305..4808880) Escherichia coli 55989 7145371 YP_002405553.1 CDS dipZ NC_011748.1 4808917 4810614 R two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm; thiol:disulfide interchange protein complement(4808917..4810614) Escherichia coli 55989 7149159 YP_002405554.1 CDS cutA NC_011748.1 4810590 4810928 R copper binding protein required for copper tolerance; involved in resistance toward heavy metals; divalent-cation tolerance protein CutA complement(4810590..4810928) Escherichia coli 55989 7145920 YP_002405555.1 CDS dcuA NC_011748.1 4811044 4812345 R functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB; anaerobic C4-dicarboxylate transporter complement(4811044..4812345) Escherichia coli 55989 7145798 YP_002405556.1 CDS aspA NC_011748.1 4812463 4813899 R catalyzes the formation of fumarate from aspartate; aspartate ammonia-lyase complement(4812463..4813899) Escherichia coli 55989 7145860 YP_002405557.1 CDS fxsA NC_011748.1 4814236 4814712 D F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein; FxsA protein 4814236..4814712 Escherichia coli 55989 7145571 YP_002405558.1 CDS yjeH NC_011748.1 4814728 4815984 R uncharacterized member of the APC superfamily of amino acid transporters; unknown function; hypothetical protein complement(4814728..4815984) Escherichia coli 55989 7146235 YP_002405559.1 CDS groES NC_011748.1 4816260 4816553 D 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring; co-chaperonin GroES 4816260..4816553 Escherichia coli 55989 7149169 YP_002405560.1 CDS groEL NC_011748.1 4816597 4818243 D 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth; molecular chaperone GroEL 4816597..4818243 Escherichia coli 55989 7146368 YP_002405561.1 CDS yjeI NC_011748.1 4818381 4818734 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4818381..4818734 Escherichia coli 55989 7146367 YP_002405562.1 CDS yjeJ NC_011748.1 4818937 4819806 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4818937..4819806) Escherichia coli 55989 7149170 YP_002405563.1 CDS yjeK NC_011748.1 4820196 4821224 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 2019591, 10629195; Product type pe : enzyme; lysine aminomutase complement(4820196..4821224) Escherichia coli 55989 7149171 YP_002405564.1 CDS efp NC_011748.1 4821266 4821832 D Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA; elongation factor P 4821266..4821832 Escherichia coli 55989 7149172 YP_002405565.1 CDS ecnA NC_011748.1 4821884 4822009 D acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex; entericidin A 4821884..4822009 Escherichia coli 55989 7145981 YP_002405566.1 CDS ecnB NC_011748.1 4822120 4822266 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 98344100, 9677290; Product type lp : lipoprotein; entericidin B membrane lipoprotein 4822120..4822266 Escherichia coli 55989 7145971 YP_002405567.1 CDS sugE NC_011748.1 4822441 4822758 D member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations; quaternary ammonium compound-resistance protein SugE 4822441..4822758 Escherichia coli 55989 7145972 YP_002405568.1 CDS blc NC_011748.1 4822755 4823288 R lipocalin; globomycin-sensitive outer membrane lipoprotein; outer membrane lipoprotein Blc complement(4822755..4823288) Escherichia coli 55989 7147737 YP_002405569.1 CDS ampC NC_011748.1 4823377 4824510 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 92212899, 97464439, 99421326, 10595535, 6795623, 7041115, 9819201; Product type e : enzyme; beta-lactamase complement(4823377..4824510) Escherichia coli 55989 7145633 YP_002405570.1 CDS frdD NC_011748.1 4824573 4824932 R in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane; fumarate reductase subunit D complement(4824573..4824932) Escherichia coli 55989 7145494 YP_002405571.1 CDS frdC NC_011748.1 4824943 4825338 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase subunit C complement(4824943..4825338) Escherichia coli 55989 7146182 YP_002405572.1 CDS frdB NC_011748.1 4825349 4826083 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase iron-sulfur subunit complement(4825349..4826083) Escherichia coli 55989 7146181 YP_002405573.1 CDS frdA NC_011748.1 4826076 4827884 R part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB; fumarate reductase flavoprotein subunit complement(4826076..4827884) Escherichia coli 55989 7146180 YP_002405574.1 CDS poxA NC_011748.1 4828209 4829186 D lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA; lysyl-tRNA synthetase 4828209..4829186 Escherichia coli 55989 7146179 YP_002405575.1 CDS yjeM NC_011748.1 4829405 4830907 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter 4829405..4830907 Escherichia coli 55989 7147218 YP_002405576.1 CDS yjeN NC_011748.1 4830959 4831273 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4830959..4831273 Escherichia coli 55989 7149173 YP_002405577.1 CDS yjeO NC_011748.1 4831270 4831584 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4831270..4831584 Escherichia coli 55989 7149174 YP_002405578.1 CDS yjeP NC_011748.1 4831613 4834936 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; hypothetical protein complement(4831613..4834936) Escherichia coli 55989 7149175 YP_002405579.1 CDS psd NC_011748.1 4834958 4835926 R catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine; phosphatidylserine decarboxylase complement(4834958..4835926) Escherichia coli 55989 7149176 YP_002405580.1 CDS rsgA NC_011748.1 4836023 4837075 R EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity; ribosome-associated GTPase complement(4836023..4837075) Escherichia coli 55989 7147268 YP_002405581.1 CDS orn NC_011748.1 4837170 4837715 D 3'-5' exoribonuclease specific for small oligoribonuclotides; oligoribonuclease 4837170..4837715 Escherichia coli 55989 7147534 YP_002405582.1 CDS yjeS NC_011748.1 4838494 4839633 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pc : carrier; Fe-S electron transport protein complement(4838494..4839633) Escherichia coli 55989 7145366 YP_002405583.1 CDS yjeF NC_011748.1 4839632 4841179 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; hypothetical protein 4839632..4841179 Escherichia coli 55989 7149177 YP_002405584.1 CDS yjeE NC_011748.1 4841151 4841612 D possibly involved in cell wall synthesis; ATPase 4841151..4841612 Escherichia coli 55989 7149168 YP_002405585.1 CDS amiB NC_011748.1 4841631 4842968 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21348478, 87242501, 1594459, 7511774; Product type e : enzyme; N-acetylmuramoyl-l-alanine amidase II 4841631..4842968 Escherichia coli 55989 7149167 YP_002405586.1 CDS mutL NC_011748.1 4842978 4844825 D This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex; DNA mismatch repair protein 4842978..4844825 Escherichia coli 55989 7145491 YP_002405587.1 CDS miaA NC_011748.1 4844818 4845768 D IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity; tRNA delta(2)-isopentenylpyrophosphate transferase 4844818..4845768 Escherichia coli 55989 7146932 YP_002405588.1 CDS hfq NC_011748.1 4845854 4846162 D Stimulates the elongation of poly(A) tails; RNA-binding protein Hfq 4845854..4846162 Escherichia coli 55989 7146852 YP_002405589.1 CDS hflX NC_011748.1 4846239 4847519 D involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein; GTPase HflX 4846239..4847519 Escherichia coli 55989 7146424 YP_002405590.1 CDS hflK NC_011748.1 4847605 4848864 D with HflC inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflK 4847605..4848864 Escherichia coli 55989 7146423 YP_002405591.1 CDS hflC NC_011748.1 4848867 4849871 D with HflK inhibits proteolysis of lambda cII protein by FtsH; FtsH protease regulator HflC 4848867..4849871 Escherichia coli 55989 7146422 YP_002405592.1 CDS yjeT NC_011748.1 4849953 4850150 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4849953..4850150 Escherichia coli 55989 7146420 YP_002405593.1 CDS purA NC_011748.1 4850254 4851552 D catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis; adenylosuccinate synthetase 4850254..4851552 Escherichia coli 55989 7149178 YP_002405594.1 CDS nsrR NC_011748.1 4851757 4852182 D negatively regulates the transcription of genes upregulated by nitrosative stress; transcriptional repressor NsrR 4851757..4852182 Escherichia coli 55989 7147292 YP_002405595.1 CDS rnr NC_011748.1 4852221 4854662 D 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs; exoribonuclease R 4852221..4854662 Escherichia coli 55989 7147034 YP_002405596.1 CDS rlmB NC_011748.1 4854842 4855573 D Specifically methylates the ribose of guanosine 2251 in 23S rRNA; 23S rRNA (guanosine-2'-O-)-methyltransferase 4854842..4855573 Escherichia coli 55989 7147455 YP_002405597.1 CDS yjfI NC_011748.1 4855700 4856101 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4855700..4856101 Escherichia coli 55989 7147423 YP_002405598.1 CDS yjfJ NC_011748.1 4856120 4856818 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator effector protein 4856120..4856818 Escherichia coli 55989 7149181 YP_002405599.1 CDS yjfK NC_011748.1 4856869 4857528 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4856869..4857528 Escherichia coli 55989 7149182 YP_002405600.1 CDS yjfL NC_011748.1 4857546 4857944 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4857546..4857944 Escherichia coli 55989 7149183 YP_002405601.1 CDS EC55989_4740 NC_011748.1 4857863 4857970 R hypothetical protein complement(4857863..4857970) Escherichia coli 55989 7149184 YP_002405602.1 CDS yjfM NC_011748.1 4857954 4858592 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4857954..4858592 Escherichia coli 55989 7145156 YP_002405603.1 CDS yjfC NC_011748.1 4858595 4859758 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; synthetase/amidase 4858595..4859758 Escherichia coli 55989 7149185 YP_002405604.1 CDS aidB NC_011748.1 4859842 4861467 D catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA; isovaleryl CoA dehydrogenase 4859842..4861467 Escherichia coli 55989 7149179 YP_002405605.1 CDS yjfN NC_011748.1 4861584 4861859 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4861584..4861859) Escherichia coli 55989 7145476 YP_002405606.1 CDS yjfO NC_011748.1 4862008 4862337 R in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility; biofilm stress and motility protein A complement(4862008..4862337) Escherichia coli 55989 7149186 YP_002405607.1 CDS yjfP NC_011748.1 4862519 4863268 D YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo; esterase 4862519..4863268 Escherichia coli 55989 7149187 YP_002405608.1 CDS ulaR NC_011748.1 4863265 4864020 R negative regulator of ulaG and ulaABCDEF; transcriptional repressor UlaR complement(4863265..4864020) Escherichia coli 55989 7149188 YP_002405609.1 CDS ulaG NC_011748.1 4864128 4865192 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12644495, 15808744; Product type pe : enzyme; L-ascorbate 6-phosphate lactonase complement(4864128..4865192) Escherichia coli 55989 7147920 YP_002405610.1 CDS ulaA NC_011748.1 4865547 4866944 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 4865547..4866944 Escherichia coli 55989 7147919 YP_002405611.1 CDS ulaB NC_011748.1 4866960 4867265 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIB 4866960..4867265 Escherichia coli 55989 7147913 YP_002405612.1 CDS ulaC NC_011748.1 4867275 4867739 D involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; PTS system L-ascorbate-specific transporter subunit IIA 4867275..4867739 Escherichia coli 55989 7147914 YP_002405613.1 CDS ulaD NC_011748.1 4867753 4868403 D catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization; 3-keto-L-gulonate-6-phosphate decarboxylase 4867753..4868403 Escherichia coli 55989 7147915 YP_002405614.1 CDS ulaE NC_011748.1 4868413 4869267 D UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway; L-xylulose 5-phosphate 3-epimerase 4868413..4869267 Escherichia coli 55989 7147916 YP_002405615.1 CDS sgaE NC_011748.1 4869267 4869953 D catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source; L-ribulose-5-phosphate 4-epimerase 4869267..4869953 Escherichia coli 55989 7147917 YP_002405616.1 CDS yagU NC_011748.1 4870050 4870601 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; Inner membrane protein yagU 4870050..4870601 Escherichia coli 55989 7147918 YP_002405617.1 CDS yjfY NC_011748.1 4870676 4870951 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4870676..4870951) Escherichia coli 55989 7148054 YP_002405618.1 CDS rpsF NC_011748.1 4871278 4871673 D binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21; 30S ribosomal protein S6 4871278..4871673 Escherichia coli 55989 7149189 YP_002405619.1 CDS priB NC_011748.1 4871680 4871994 D binds single-stranded DNA at the primosome assembly site; primosomal replication protein N 4871680..4871994 Escherichia coli 55989 7147510 YP_002405620.1 CDS rpsR NC_011748.1 4871999 4872226 D binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit; 30S ribosomal protein S18 4871999..4872226 Escherichia coli 55989 7147245 YP_002405621.1 CDS rplI NC_011748.1 4872268 4872717 D in Escherichia coli this protein is wrapped around the base of the L1 stalk; 50S ribosomal protein L9 4872268..4872717 Escherichia coli 55989 7147522 YP_002405622.1 CDS yjfZ NC_011748.1 4872788 4873582 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4872788..4873582) Escherichia coli 55989 7147469 YP_002405623.1 CDS EC55989_4763 NC_011748.1 4873929 4874351 D hypothetical protein 4873929..4874351 Escherichia coli 55989 7149190 YP_002405624.1 CDS EC55989_4764 NC_011748.1 4874205 4874636 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase complement(4874205..4874636) Escherichia coli 55989 7145157 YP_002405625.1 CDS ydcM NC_011748.1 4874644 4875852 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; transposase 4874644..4875852 Escherichia coli 55989 7145158 YP_002405626.1 CDS ytfB NC_011748.1 4875987 4876625 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 8559074; Product type ps : structure; cell envelope opacity-associated protein complement(4875987..4876625) Escherichia coli 55989 7148393 YP_002405627.1 CDS fklB NC_011748.1 4876844 4877464 D FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; peptidyl-prolyl cis-trans isomerase 4876844..4877464 Escherichia coli 55989 7149469 YP_002405628.1 CDS cycA NC_011748.1 4877773 4879185 D involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine; D-alanine/D-serine/glycine permease 4877773..4879185 Escherichia coli 55989 7146119 YP_002405629.1 CDS ytfE NC_011748.1 4879230 4879892 R Involved in anaerobic NO protection and iron metabolism; iron-sulfur cluster repair di-iron protein complement(4879230..4879892) Escherichia coli 55989 7145806 YP_002405630.1 CDS ytfF NC_011748.1 4880000 4880974 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(4880000..4880974) Escherichia coli 55989 7149470 YP_002405631.1 CDS ytfG NC_011748.1 4881073 4881933 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14747727; Product type e : enzyme; NAD(P)H:quinone oxidoreductase complement(4881073..4881933) Escherichia coli 55989 7149471 YP_002405632.1 CDS ytfH NC_011748.1 4882022 4882402 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 20088838; Product type pr : regulator; transcriptional regulator 4882022..4882402 Escherichia coli 55989 7149472 YP_002405633.1 CDS cpdB NC_011748.1 4882531 4884474 R periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate; bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic protein complement(4882531..4884474) Escherichia coli 55989 7149473 YP_002405634.1 CDS cysQ NC_011748.1 4884664 4885404 D catalyzes the formation of AMP from adenosine-3',5'-bisphosphate; adenosine-3'(2'),5'-bisphosphate nucleotidase 4884664..4885404 Escherichia coli 55989 7145745 YP_002405635.1 CDS ytfJ NC_011748.1 4885394 4885951 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pr : regulator; transcriptional regulator complement(4885394..4885951) Escherichia coli 55989 7145833 YP_002405636.1 CDS ytfK NC_011748.1 4886276 4886482 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4886276..4886482 Escherichia coli 55989 7149474 YP_002405637.1 CDS ytfL NC_011748.1 4886544 4887887 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(4886544..4887887) Escherichia coli 55989 7149475 YP_002405638.1 CDS msrA NC_011748.1 4888210 4888848 R this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress; methionine sulfoxide reductase A complement(4888210..4888848) Escherichia coli 55989 7149476 YP_002405639.1 CDS ytfM NC_011748.1 4889054 4890787 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; outer membrane protein 4889054..4890787 Escherichia coli 55989 7146910 YP_002405640.1 CDS ytfN NC_011748.1 4890784 4894563 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4890784..4894563 Escherichia coli 55989 7149477 YP_002405641.1 CDS ytfP NC_011748.1 4894566 4894907 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4894566..4894907 Escherichia coli 55989 7149478 YP_002405642.1 CDS chpS NC_011748.1 4895119 4895370 D part of the toxin-antitoxin ChpB-ChpS system; antitoxin ChpS 4895119..4895370 Escherichia coli 55989 7149479 YP_002405643.1 CDS chpB NC_011748.1 4895364 4895714 D toxin of the ChpB-ChpS toxin-antitoxin system; toxin ChpB 4895364..4895714 Escherichia coli 55989 7145706 YP_002405644.1 CDS ppa NC_011748.1 4895794 4896324 R catalyzes the hydrolysis of pyrophosphate to phosphate; inorganic pyrophosphatase complement(4895794..4896324) Escherichia coli 55989 7145704 YP_002405645.1 CDS ytfQ NC_011748.1 4896634 4897590 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 9298646; Product type pt : transporter; sugar transporter subunit: periplasmic-binding component of ABC superfamily 4896634..4897590 Escherichia coli 55989 7147220 YP_002405646.1 CDS ytfR NC_011748.1 4897900 4899402 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sugar transporter subunit: ATP-binding component of ABC superfamily 4897900..4899402 Escherichia coli 55989 7149480 YP_002405647.1 CDS ytfT NC_011748.1 4899416 4900438 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; sugar transporter subunit: membrane component of ABC superfamily 4899416..4900438 Escherichia coli 55989 7149481 YP_002405648.1 CDS yjfF NC_011748.1 4900425 4901420 D membrane component of a sugar ABC transporter system; ABC transporter permease 4900425..4901420 Escherichia coli 55989 7149482 YP_002405649.1 CDS fbp NC_011748.1 4901453 4902451 R catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate; fructose-1,6-bisphosphatase complement(4901453..4902451) Escherichia coli 55989 7149180 YP_002405650.1 CDS mpl NC_011748.1 4902627 4904000 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96404780, 2843822, 7984428, 8808921; Product type e : enzyme; UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase 4902627..4904000 Escherichia coli 55989 7146064 YP_002405651.1 CDS yjgA NC_011748.1 4904151 4904702 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4904151..4904702) Escherichia coli 55989 7146891 YP_002405652.1 CDS pmbA NC_011748.1 4904796 4906148 D protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD; peptidase PmbA 4904796..4906148 Escherichia coli 55989 7149191 YP_002405653.1 CDS cybC NC_011748.1 4906331 4906717 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1761034, 8499452, 10393541; Product type c : carrier; soluble cytochrome b562 4906331..4906717 Escherichia coli 55989 7147199 YP_002405654.1 CDS nrdG NC_011748.1 4906762 4907226 R activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions; anaerobic ribonucleotide reductase-activating protein complement(4906762..4907226) Escherichia coli 55989 7145805 YP_002405655.1 CDS nrdD NC_011748.1 4907384 4909522 R Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates; anaerobic ribonucleoside triphosphate reductase complement(4907384..4909522) Escherichia coli 55989 7147023 YP_002405656.1 CDS treC NC_011748.1 4909925 4911580 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90264345, 93302496, 8083158, 8421692; Product type e : enzyme; trehalose-6-phosphate hydrolase complement(4909925..4911580) Escherichia coli 55989 7147020 YP_002405657.1 CDS treB NC_011748.1 4911630 4913051 R phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel; PTS system trehalose(maltose)-specific transporter subunit IIBC complement(4911630..4913051) Escherichia coli 55989 7147837 YP_002405658.1 CDS treR NC_011748.1 4913170 4914117 R regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon; trehalose repressor complement(4913170..4914117) Escherichia coli 55989 7147836 YP_002405659.1 CDS mgtA NC_011748.1 4914496 4917192 D P-type ATPase involved in magnesium influx; magnesium-transporting ATPase MgtA 4914496..4917192 Escherichia coli 55989 7147839 YP_002405660.1 CDS EC55989_4801 NC_011748.1 4917420 4918400 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; transposase, IS110 family complement(4917420..4918400) Escherichia coli 55989 7146843 YP_002405661.1 CDS yjgF NC_011748.1 4918677 4919063 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 12515541, 10493123, 10595546, 9298646; Product type pe : enzyme; ketoacid-binding protein complement(4918677..4919063) Escherichia coli 55989 7145159 YP_002405662.1 CDS pyrI NC_011748.1 4919136 4919597 R involved in the allosteric regulation of aspartate carbamoyltransferase; aspartate carbamoyltransferase complement(4919136..4919597) Escherichia coli 55989 7149194 YP_002405663.1 CDS pyrB NC_011748.1 4919610 4920545 R catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis; aspartate carbamoyltransferase complement(4919610..4920545) Escherichia coli 55989 7147324 YP_002405664.1 CDS pyrL NC_011748.1 4920549 4920683 R Evidence 1c : Function experimentally demonstrated in the studied genus; Product type l : leader peptide; pyrBI operon leader peptide complement(4920549..4920683) Escherichia coli 55989 7147317 YP_002405665.1 CDS yjgH NC_011748.1 4920964 4921359 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; mRNA endoribonuclease complement(4920964..4921359) Escherichia coli 55989 7147325 YP_002405666.1 CDS yjgI NC_011748.1 4921490 4922203 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase complement(4921490..4922203) Escherichia coli 55989 7149195 YP_002405667.1 CDS yjgJ NC_011748.1 4922274 4922867 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 4922274..4922867 Escherichia coli 55989 7149196 YP_002405668.1 CDS yjgK NC_011748.1 4923012 4923464 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 11115104; hypothetical protein 4923012..4923464 Escherichia coli 55989 7149197 YP_002405669.1 CDS argI NC_011748.1 4925249 4926253 R catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III.; ornithine carbamoyltransferase subunit I complement(4925249..4926253) Escherichia coli 55989 7149200 YP_002405670.1 CDS yjgD NC_011748.1 4926415 4926831 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4926415..4926831 Escherichia coli 55989 7145531 YP_002405671.1 CDS yjgM NC_011748.1 4926877 4927380 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; acetyltransferase complement(4926877..4927380) Escherichia coli 55989 7149193 YP_002405672.1 CDS yjgN NC_011748.1 4927573 4928769 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4927573..4928769 Escherichia coli 55989 7149201 YP_002405673.1 CDS valS NC_011748.1 4928825 4931680 R valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain; valyl-tRNA synthetase complement(4928825..4931680) Escherichia coli 55989 7149202 YP_002405674.1 CDS holC NC_011748.1 4931680 4932123 R binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit chi complement(4931680..4932123) Escherichia coli 55989 7147946 YP_002405675.1 CDS pepA NC_011748.1 4932257 4933768 R catalyzes the removal of N-terminal amino acids preferably leucine from various peptides; leucyl aminopeptidase complement(4932257..4933768) Escherichia coli 55989 7146455 YP_002405676.1 CDS yjgP NC_011748.1 4934035 4935135 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4934035..4935135 Escherichia coli 55989 7147130 YP_002405677.1 CDS yjgQ NC_011748.1 4935135 4936217 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein 4935135..4936217 Escherichia coli 55989 7149203 YP_002405678.1 CDS yjgR NC_011748.1 4936336 4937838 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; ATPase complement(4936336..4937838) Escherichia coli 55989 7149204 YP_002405679.1 CDS idnR NC_011748.1 4937916 4938914 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9119199, 98324983, 9658018; Product type r : regulator; DNA-binding transcriptional repressor, 5-gluconate-binding complement(4937916..4938914) Escherichia coli 55989 7149205 YP_002405680.1 CDS idnT NC_011748.1 4938981 4940300 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 172599, 9119199, 93139975, 98324983, 9658018; Product type t : transporter; L-idonate and D-gluconate transporter complement(4938981..4940300) Escherichia coli 55989 7146543 YP_002405681.1 CDS idnO NC_011748.1 4940365 4941129 R Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate; gluconate 5-dehydrogenase complement(4940365..4941129) Escherichia coli 55989 7146544 YP_002405682.1 CDS idnD NC_011748.1 4941153 4942184 R NAD-binding; L-idonate 5-dehydrogenase complement(4941153..4942184) Escherichia coli 55989 7146542 YP_002405683.1 CDS idnK NC_011748.1 4942401 4942964 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 87310381, 93139975, 98324983, 9658018, 14832279; Product type e : enzyme; D-gluconate kinase 4942401..4942964 Escherichia coli 55989 7146540 YP_002405684.1 CDS yjgB NC_011748.1 4942968 4943987 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 12147722; Product type pe : enzyme; alcohol dehydrogenase, Zn-dependent and NAD(P)-binding complement(4942968..4943987) Escherichia coli 55989 7146541 YP_002405685.1 CDS EC55989_4828 NC_011748.1 4944062 4944268 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4944062..4944268) Escherichia coli 55989 7149192 YP_002405686.1 CDS intB NC_011748.1 4944529 4945719 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; integrase; KpLE2 phage-like element 4944529..4945719 Escherichia coli 55989 7145367 YP_002405687.1 CDS EC55989_4830 NC_011748.1 4946043 4947542 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; membrane-associated, metal-dependent hydrolase complement(4946043..4947542) Escherichia coli 55989 7146608 YP_002405688.1 CDS EC55989_4831 NC_011748.1 4947716 4948507 R Evidence 2b : Function of strongly homologous gene; Product type f : factor; surface protein precursor complement(4947716..4948507) Escherichia coli 55989 7145161 YP_002405689.1 CDS EC55989_4832 NC_011748.1 4949069 4950718 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4949069..4950718 Escherichia coli 55989 7145162 YP_002405690.1 CDS EC55989_4833 NC_011748.1 4950723 4952048 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4950723..4952048 Escherichia coli 55989 7145163 YP_002405691.1 CDS EC55989_4834 NC_011748.1 4952008 4957083 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4952008..4957083 Escherichia coli 55989 7145164 YP_002405692.1 CDS EC55989_4835 NC_011748.1 4957121 4957639 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4957121..4957639 Escherichia coli 55989 7145165 YP_002405693.1 CDS EC55989_4836 NC_011748.1 4957640 4957945 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4957640..4957945 Escherichia coli 55989 7145166 YP_002405694.1 CDS EC55989_4837 NC_011748.1 4958207 4958800 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4958207..4958800 Escherichia coli 55989 7145167 YP_002405695.1 CDS EC55989_4838 NC_011748.1 4958859 4959215 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16102010; Product type pe : enzyme; DNA thiolation protein; phage protein complement(4958859..4959215) Escherichia coli 55989 7145168 YP_002405696.1 CDS EC55989_4839 NC_011748.1 4959215 4961263 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16102010; Product type pe : enzyme; ATPase involved in DNA thiolation complement(4959215..4961263) Escherichia coli 55989 7145169 YP_002405697.1 CDS EC55989_4840 NC_011748.1 4961205 4962839 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16102010; Product type pe : enzyme; hypothetical protein complement(4961205..4962839) Escherichia coli 55989 7145170 YP_002405698.1 CDS EC55989_4841 NC_011748.1 4962836 4963921 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 16102010; Product type pe : enzyme; DNA thiolation protein; phage protein complement(4962836..4963921) Escherichia coli 55989 7145171 YP_002405699.1 CDS EC55989_4842 NC_011748.1 4964136 4964288 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4964136..4964288) Escherichia coli 55989 7145172 YP_002405700.1 CDS EC55989_4843 NC_011748.1 4964384 4964557 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4964384..4964557 Escherichia coli 55989 7145173 YP_002405701.1 CDS EC55989_4844 NC_011748.1 4964554 4964898 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; conjugation inhibition protein, immunity protein 4964554..4964898 Escherichia coli 55989 7145174 YP_002405702.1 CDS EC55989_4845 NC_011748.1 4964917 4965516 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4964917..4965516) Escherichia coli 55989 7145175 YP_002405703.1 CDS EC55989_4846 NC_011748.1 4965553 4965711 R hypothetical protein complement(4965553..4965711) Escherichia coli 55989 7145176 YP_002405704.1 CDS EC55989_4847 NC_011748.1 4965708 4965944 R Evidence 4 : Homologs of previously reported genes of unknown function; phage regulatory protein complement(4965708..4965944) Escherichia coli 55989 7145177 YP_002405705.1 CDS EC55989_4848 NC_011748.1 4966013 4966720 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4966013..4966720) Escherichia coli 55989 7145178 YP_002405706.1 CDS EC55989_4849 NC_011748.1 4966835 4967302 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4966835..4967302) Escherichia coli 55989 7145179 YP_002405707.1 CDS EC55989_4850 NC_011748.1 4967418 4968626 D Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L 4967418..4968626 Escherichia coli 55989 7147438 YP_002405708.1 CDS EC55989_4851 NC_011748.1 4968992 4969273 R hypothetical protein complement(4968992..4969273) Escherichia coli 55989 7145181 YP_002405709.1 CDS EC55989_4852 NC_011748.1 4969248 4970456 R Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L complement(4969248..4970456) Escherichia coli 55989 7145182 YP_002405710.1 CDS EC55989_4853 NC_011748.1 4970396 4971535 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4970396..4971535) Escherichia coli 55989 7145183 YP_002405711.1 CDS EC55989_4854 NC_011748.1 4971979 4972299 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; monooxygenase 4971979..4972299 Escherichia coli 55989 7147439 YP_002405712.1 CDS EC55989_4855 NC_011748.1 4972181 4972678 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4972181..4972678 Escherichia coli 55989 7145185 YP_002405713.1 CDS EC55989_4856 NC_011748.1 4972686 4973372 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; ArsR family transcriptional regulator 4972686..4973372 Escherichia coli 55989 7145186 YP_002405714.1 CDS EC55989_4857 NC_011748.1 4973350 4973976 R Evidence 2b : Function of strongly homologous gene; Product type r : regulator; tetracycline repressor protein TetR complement(4973350..4973976) Escherichia coli 55989 7145187 YP_002405715.1 CDS EC55989_4858 NC_011748.1 4974007 4975260 D Evidence 2b : Function of strongly homologous gene; Product type pt : transporter; Tetracycline resistance protein, class B (TETA(B) ) (Metal-tetracycline/H(+) antiporter) 4974007..4975260 Escherichia coli 55989 7145188 YP_002405716.1 CDS EC55989_4859 NC_011748.1 4975373 4976041 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; Transcriptional regulator complement(4975373..4976041) Escherichia coli 55989 7145189 YP_002405717.1 CDS EC55989_4860 NC_011748.1 4976054 4976470 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; operon control protein 4976054..4976470 Escherichia coli 55989 7145190 YP_002405718.1 CDS EC55989_4861 NC_011748.1 4976480 4977688 R Evidence 2b : Function of strongly homologous gene; PubMedId : 10781570; Product type pe : enzyme; transposase, IS4 family, IS10L complement(4976480..4977688) Escherichia coli 55989 7145191 YP_002405719.1 CDS EC55989_4862 NC_011748.1 4979387 4980142 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4979387..4980142) Escherichia coli 55989 7145299 YP_002405720.1 CDS EC55989_4863 NC_011748.1 4980287 4980556 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4980287..4980556) Escherichia coli 55989 7145193 YP_002405721.1 CDS insE NC_011748.1 4980643 4980951 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin; IS3 element protein InsE 4980643..4980951 Escherichia coli 55989 7145194 YP_002405722.1 CDS insF NC_011748.1 4980948 4981814 D Evidence 1b : Function experimentally demonstrated in the studied species; Product type h : extrachromosomal origin; IS3 element protein InsF 4980948..4981814 Escherichia coli 55989 7146593 YP_002405723.1 CDS EC55989_4866 NC_011748.1 4981951 4982742 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4981951..4982742) Escherichia coli 55989 7146595 YP_002405724.1 CDS EC55989_4867 NC_011748.1 4982813 4983634 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4982813..4983634) Escherichia coli 55989 7145195 YP_002405725.1 CDS EC55989_4868 NC_011748.1 4983672 4984373 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4983672..4984373) Escherichia coli 55989 7145196 YP_002405726.1 CDS EC55989_4869 NC_011748.1 4984370 4984945 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4984370..4984945) Escherichia coli 55989 7145197 YP_002405727.1 CDS EC55989_4870 NC_011748.1 4985107 4985910 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4985107..4985910) Escherichia coli 55989 7145198 YP_002405728.1 CDS EC55989_4871 NC_011748.1 4985699 4986049 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4985699..4986049 Escherichia coli 55989 7145199 YP_002405729.1 CDS EC55989_4872 NC_011748.1 4986234 4986908 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4986234..4986908 Escherichia coli 55989 7145200 YP_002405730.1 CDS EC55989_4873 NC_011748.1 4987187 4987963 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4987187..4987963) Escherichia coli 55989 7145201 YP_002405731.1 CDS EC55989_4874 NC_011748.1 4987966 4988475 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4987966..4988475) Escherichia coli 55989 7145202 YP_002405732.1 CDS EC55989_4875 NC_011748.1 4988634 4989155 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4988634..4989155 Escherichia coli 55989 7145203 YP_002405733.1 CDS EC55989_4876 NC_011748.1 4989073 4989594 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4989073..4989594 Escherichia coli 55989 7145204 YP_002405734.1 CDS EC55989_4877 NC_011748.1 4989608 4990630 D Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase ORF A, IS100 4989608..4990630 Escherichia coli 55989 7145205 YP_002405735.1 CDS EC55989_4878 NC_011748.1 4990627 4991409 D Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase/IS protein 4990627..4991409 Escherichia coli 55989 7145206 YP_002405736.1 CDS EC55989_4879 NC_011748.1 4991534 4991707 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4991534..4991707) Escherichia coli 55989 7145207 YP_002405737.1 CDS EC55989_4880 NC_011748.1 4991625 4992356 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4991625..4992356) Escherichia coli 55989 7145208 YP_002405738.1 CDS EC55989_4881 NC_011748.1 4992698 4992886 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4992698..4992886) Escherichia coli 55989 7145209 YP_002405739.1 CDS EC55989_4882 NC_011748.1 4993026 4993556 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4993026..4993556 Escherichia coli 55989 7145210 YP_002405740.1 CDS EC55989_4883 NC_011748.1 4994306 4994485 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(4994306..4994485) Escherichia coli 55989 7145211 YP_002405741.1 CDS EC55989_4884 NC_011748.1 4995161 4996030 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 4995161..4996030 Escherichia coli 55989 7145212 YP_002405742.1 CDS EC55989_4885 NC_011748.1 4996027 4996989 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(4996027..4996989) Escherichia coli 55989 7145213 YP_002405743.1 CDS EC55989_4886 NC_011748.1 4997095 4997979 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; GTP-binding protein 4997095..4997979 Escherichia coli 55989 7145214 YP_002405744.1 CDS yfjR NC_011748.1 4998182 4998862 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; HTH-type transcriptional regulator 4998182..4998862 Escherichia coli 55989 7145215 YP_002405745.1 CDS EC55989_4888 NC_011748.1 4998905 4999687 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4998905..4999687 Escherichia coli 55989 7148787 YP_002405746.1 CDS EC55989_4889 NC_011748.1 4999693 4999926 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 4999693..4999926 Escherichia coli 55989 7145216 YP_002405747.1 CDS EC55989_4890 NC_011748.1 5000016 5000834 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5000016..5000834 Escherichia coli 55989 7145217 YP_002405748.1 CDS EC55989_4891 NC_011748.1 5000926 5001411 D Evidence 4 : Homologs of previously reported genes of unknown function; antirestriction protein 5000926..5001411 Escherichia coli 55989 7145218 YP_002405749.1 CDS yeeS NC_011748.1 5001456 5001902 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 11053371; Product type pf : factor; DNA repair protein; CP4-44 prophage 5001456..5001902 Escherichia coli 55989 7145219 YP_002405750.1 CDS yeeT NC_011748.1 5001989 5002210 D Evidence 4 : Homologs of previously reported genes of unknown function; Product type h : extrachromosomal origin; CP4-44 prophage 5001989..5002210 Escherichia coli 55989 7148607 YP_002405751.1 CDS yeeU NC_011748.1 5002290 5002658 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14594833; Product type h : extrachromosomal origin; antitoxin of the YeeV-YeeU toxin-antitoxin system; CP4-44 prophage 5002290..5002658 Escherichia coli 55989 7148611 YP_002405752.1 CDS EC55989_4895 NC_011748.1 5002607 5003125 D Evidence 4 : Homologs of previously reported genes of unknown function; phage protein 5002607..5003125 Escherichia coli 55989 7148615 YP_002405753.1 CDS yeeW NC_011748.1 5003122 5003610 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5003122..5003610 Escherichia coli 55989 7145220 YP_002405754.1 CDS EC55989_4897 NC_011748.1 5003258 5003827 D Evidence 6 : Doubtful CDS; hypothetical protein 5003258..5003827 Escherichia coli 55989 7148622 YP_002405755.1 CDS EC55989_4898 NC_011748.1 5003912 5004058 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5003912..5004058 Escherichia coli 55989 7145221 YP_002405756.1 CDS EC55989_4899 NC_011748.1 5004471 5005478 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5004471..5005478) Escherichia coli 55989 7145222 YP_002405757.1 CDS EC55989_4900 NC_011748.1 5005387 5007006 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5005387..5007006) Escherichia coli 55989 7145223 YP_002405758.1 CDS EC55989_4901 NC_011748.1 5007016 5008350 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5007016..5008350) Escherichia coli 55989 7145224 YP_002405759.1 CDS EC55989_4902 NC_011748.1 5008307 5008633 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(5008307..5008633) Escherichia coli 55989 7145225 YP_002405760.1 CDS EC55989_4903 NC_011748.1 5008968 5009840 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5008968..5009840) Escherichia coli 55989 7145226 YP_002405761.1 CDS EC55989_4904 NC_011748.1 5010085 5010465 R Evidence 6 : Doubtful CDS; hypothetical protein complement(5010085..5010465) Escherichia coli 55989 7145227 YP_002405762.1 CDS EC55989_4905 NC_011748.1 5010519 5011022 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 273224, 375010, 1849492; Product type pe : enzyme; Insertion element IS1 1/5/6 protein insB complement(5010519..5011022) Escherichia coli 55989 7145228 YP_002405763.1 CDS EC55989_4906 NC_011748.1 5010941 5011216 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1849492; Product type r : regulator; IS1 repressor protein InsA complement(5010941..5011216) Escherichia coli 55989 7145229 YP_002405764.1 CDS EC55989_4907 NC_011748.1 5011595 5011744 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5011595..5011744 Escherichia coli 55989 7145230 YP_002405765.1 CDS EC55989_4908 NC_011748.1 5012004 5012300 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator 5012004..5012300 Escherichia coli 55989 7145231 YP_002405766.1 CDS EC55989_4909 NC_011748.1 5012450 5012629 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5012450..5012629 Escherichia coli 55989 7145232 YP_002405767.1 CDS EC55989_4910 NC_011748.1 5012590 5012769 D Evidence 5 : No homology to any previously reported sequences; hypothetical protein 5012590..5012769 Escherichia coli 55989 7145233 YP_002405768.1 CDS EC55989_4911 NC_011748.1 5012734 5012889 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(5012734..5012889) Escherichia coli 55989 7145234 YP_002405769.1 CDS EC55989_4912 NC_011748.1 5012930 5014006 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; Filamentation induced by cAMP protein Fic 5012930..5014006 Escherichia coli 55989 7145235 YP_002405770.1 CDS EC55989_4913 NC_011748.1 5014057 5014686 R Evidence 5 : No homology to any previously reported sequences; hypothetical protein complement(5014057..5014686) Escherichia coli 55989 7145236 YP_002405771.1 CDS insA NC_011748.1 5014728 5015003 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1849492; Product type r : regulator; IS1 repressor protein InsA; KpLE2 phage-like element 5014728..5015003 Escherichia coli 55989 7145237 YP_002405772.1 CDS insB NC_011748.1 5014922 5015425 D Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase ORF B, IS1 5014922..5015425 Escherichia coli 55989 7146579 YP_002405773.1 CDS EC55989_4916 NC_011748.1 5015597 5016421 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; Transcriptional regulator complement(5015597..5016421) Escherichia coli 55989 7146590 YP_002405774.1 CDS ptsG NC_011748.1 5016548 5018143 D Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 1508157; Product type e : enzyme; PTS system, glucose-specific enzyme II, ABC component 5016548..5018143 Escherichia coli 55989 7145238 YP_002405775.1 CDS nanE NC_011748.1 5018143 5018832 D Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate; N-acetylmannosamine-6-phosphate 2-epimerase 5018143..5018832 Escherichia coli 55989 7147287 YP_002405776.1 CDS EC55989_4919 NC_011748.1 5018893 5019108 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5018893..5019108 Escherichia coli 55989 7146956 YP_002405777.1 CDS EC55989_4920 NC_011748.1 5019087 5019308 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5019087..5019308 Escherichia coli 55989 7145239 YP_002405778.1 CDS EC55989_4921 NC_011748.1 5019316 5019588 R Evidence 6 : Doubtful CDS; hypothetical protein complement(5019316..5019588) Escherichia coli 55989 7145240 YP_002405779.1 CDS EC55989_4922 NC_011748.1 5019740 5019898 D Evidence 6 : Doubtful CDS; hypothetical protein 5019740..5019898 Escherichia coli 55989 7145241 YP_002405780.1 CDS EC55989_4923 NC_011748.1 5020393 5020686 R Evidence 7 : Gene remnant; transposase (fragment), IS110 family complement(5020393..5020686) Escherichia coli 55989 7145242 YP_002405781.1 CDS EC55989_4924 NC_011748.1 5020729 5020947 R Evidence 7 : Gene remnant; transposase (fragment), IS110 family complement(5020729..5020947) Escherichia coli 55989 7145243 YP_002405782.1 CDS vpeR NC_011748.1 5021078 5022109 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; Transcriptional regulator complement(5021078..5022109) Escherichia coli 55989 7145244 YP_002405783.1 CDS vpeA NC_011748.1 5022380 5022823 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; PTS system, specific IIA component 5022380..5022823 Escherichia coli 55989 7147952 YP_002405784.1 CDS vpeB NC_011748.1 5022839 5023126 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; PTS system, specific IIB component 5022839..5023126 Escherichia coli 55989 7147949 YP_002405785.1 CDS vpeC NC_011748.1 5023139 5024395 D membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr; PTS system ascorbate-specific transporter subunit IIC 5023139..5024395 Escherichia coli 55989 7147950 YP_002405786.1 CDS EC55989_4929 NC_011748.1 5024642 5024896 R Evidence 7 : Gene remnant; transposase ORF1, IS3 family (fragment) complement(5024642..5024896) Escherichia coli 55989 7147951 YP_002405787.1 CDS deoM NC_011748.1 5025318 5026331 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 15075407; Product type e : enzyme; Deoxyribose specific mutarotase complement(5025318..5026331) Escherichia coli 55989 7146591 YP_002405788.1 CDS deoP NC_011748.1 5026343 5027659 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 5385522, 15075407, 10648508; Product type pe : enzyme; L-fucose permease complement(5026343..5027659) Escherichia coli 55989 7145887 YP_002405789.1 CDS deoK NC_011748.1 5027687 5028634 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 10648508, 15385522; Product type e : enzyme; Deoxyribokinase complement(5027687..5028634) Escherichia coli 55989 7145888 YP_002405790.1 CDS deoQ NC_011748.1 5028910 5029695 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 15385522, 10648508; Product type pr : regulator; transcriptional regulator 5028910..5029695 Escherichia coli 55989 7145886 YP_002405791.1 CDS EC55989_4940 NC_011748.1 5030879 5032492 R Evidence 4 : Homologs of previously reported genes of unknown function; transposase ORF1, IS66 family complement(5030879..5032492) Escherichia coli 55989 7146561 YP_002405792.1 CDS EC55989_4941 NC_011748.1 5032523 5032873 R Evidence 4 : Homologs of previously reported genes of unknown function; transposase ORF2, IS66 family complement(5032523..5032873) Escherichia coli 55989 7145246 YP_002405793.1 CDS EC55989_4942 NC_011748.1 5032870 5033295 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; transposase OrfA from plasmid origin complement(5032870..5033295) Escherichia coli 55989 7145247 YP_002405794.1 CDS EC55989_4943 NC_011748.1 5033434 5033562 D Evidence 7 : Gene remnant; Product type f : factor; Protein yhdH (fragment) 5033434..5033562 Escherichia coli 55989 7145248 YP_002405795.1 CDS EC55989_4944 NC_011748.1 5033743 5034426 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pr : regulator; HTH regulator, TetR family complement(5033743..5034426) Escherichia coli 55989 7145249 YP_002405796.1 CDS EC55989_4945 NC_011748.1 5034645 5035937 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5034645..5035937) Escherichia coli 55989 7145250 YP_002405797.1 CDS EC55989_4947 NC_011748.1 5035985 5037988 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 14702297; Product type t : transporter; betaine-carnitine-choline transporter family member BetU complement(5035985..5037988) Escherichia coli 55989 7145251 YP_002405798.1 CDS EC55989_4948 NC_011748.1 5038136 5039275 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5038136..5039275) Escherichia coli 55989 7145252 YP_002405799.1 CDS msbB NC_011748.1 5039456 5040400 R Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA; lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase complement(5039456..5040400) Escherichia coli 55989 7145253 YP_002405800.1 CDS virK NC_011748.1 5040465 5041415 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1406277; Product type r : regulator; regulator of virG protein complement(5040465..5041415) Escherichia coli 55989 7146907 YP_002405801.1 CDS EC55989_4951 NC_011748.1 5041420 5042508 R Evidence 2b : Function of strongly homologous gene; Product type e : enzyme; Glycosyl transferase complement(5041420..5042508) Escherichia coli 55989 7147947 YP_002405802.1 CDS shf NC_011748.1 5042511 5043332 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; polysaccharide deacetylase complement(5042511..5043332) Escherichia coli 55989 7145254 YP_002405803.1 CDS EC55989_4953 NC_011748.1 5043497 5043841 D Evidence 2b : Function of strongly homologous gene; Product type pe : enzyme; transposase ORF A, IS911 5043497..5043841 Escherichia coli 55989 7147652 YP_002405804.1 CDS EC55989_4955 NC_011748.1 5044914 5046437 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type h : extrachromosomal origin; reverse transcriptase-like protein from prophage or plasmid 5044914..5046437 Escherichia coli 55989 7146600 YP_002405805.1 CDS yjhV NC_011748.1 5046932 5047345 D Evidence 4 : Homologs of previously reported genes of unknown function; KpLE2 phage-like element 5046932..5047345 Escherichia coli 55989 7145257 YP_002405806.1 CDS fecE NC_011748.1 5047903 5048670 R Part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter ATP-binding subunit complement(5047903..5048670) Escherichia coli 55989 7149206 YP_002405807.1 CDS EC55989_4960 NC_011748.1 5048474 5048638 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5048474..5048638 Escherichia coli 55989 7146083 YP_002405808.1 CDS fecD NC_011748.1 5048671 5049627 R Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter.; iron-dicitrate transporter subunit FecD complement(5048671..5049627) Escherichia coli 55989 7145258 YP_002405809.1 CDS fecC NC_011748.1 5049624 5050622 R part of the FecBCDE citrate-dependent iron (III) transport system; iron-dicitrate transporter permease subunit complement(5049624..5050622) Escherichia coli 55989 7146082 YP_002405810.1 CDS fecB NC_011748.1 5050619 5051521 R part of the ABC transporter involved in the uptake of citrate-dependent Fe(3+); iron-dicitrate transporter substrate-binding subunit complement(5050619..5051521) Escherichia coli 55989 7146081 YP_002405811.1 CDS fecA NC_011748.1 5051566 5053890 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 90105402, 91072220, 92269759, 2836368; Product type t : transporter; ferric citrate outer membrane transporter; KpLE2 phage-like element complement(5051566..5053890) Escherichia coli 55989 7146080 YP_002405812.1 CDS fecR NC_011748.1 5053977 5054930 R with FecA forms the FecAR signal transduction system; ferric citrate binds FecA and transmits a signal across the outer membrane to FecR. FecR transmits a signal across the cytoplasmic membrane and activates the sigma 70 protein FecI that directs the RNA polymerase to express the fecABCDE operon; fec operon regulator FecR complement(5053977..5054930) Escherichia coli 55989 7146079 YP_002405813.1 CDS fecI NC_011748.1 5054927 5055448 R Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport; RNA polymerase sigma factor FecI complement(5054927..5055448) Escherichia coli 55989 7146085 YP_002405814.1 CDS EC55989_4968 NC_011748.1 5056786 5056995 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5056786..5056995) Escherichia coli 55989 7146084 YP_002405815.1 CDS EC55989_4969 NC_011748.1 5057359 5058732 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5057359..5058732 Escherichia coli 55989 7145259 YP_002405816.1 CDS EC55989_4970 NC_011748.1 5058971 5060356 R Evidence 4 : Homologs of previously reported genes of unknown function; transposase complement(5058971..5060356) Escherichia coli 55989 7145260 YP_002405817.1 CDS EC55989_4971 NC_011748.1 5060406 5060753 R Evidence 4 : Homologs of previously reported genes of unknown function; transposase ORF2, IS66 family complement(5060406..5060753) Escherichia coli 55989 7145261 YP_002405818.1 CDS EC55989_4972 NC_011748.1 5060750 5061151 R Evidence 4 : Homologs of previously reported genes of unknown function; transposase, IS3 family complement(5060750..5061151) Escherichia coli 55989 7145262 YP_002405819.1 CDS EC55989_4973 NC_011748.1 5061485 5062006 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5061485..5062006) Escherichia coli 55989 7145263 YP_002405820.1 CDS EC55989_4974 NC_011748.1 5061907 5062314 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5061907..5062314) Escherichia coli 55989 7145264 YP_002405821.1 CDS EC55989_4975 NC_011748.1 5062568 5063173 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5062568..5063173) Escherichia coli 55989 7145265 YP_002405822.1 CDS EC55989_4976 NC_011748.1 5063878 5064054 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; transcriptional regulator complement(5063878..5064054) Escherichia coli 55989 7145266 YP_002405823.1 CDS EC55989_4977 NC_011748.1 5064355 5064621 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5064355..5064621) Escherichia coli 55989 7145267 YP_002405824.1 CDS EC55989_4978 NC_011748.1 5064567 5064968 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5064567..5064968 Escherichia coli 55989 7145268 YP_002405825.1 CDS EC55989_4979 NC_011748.1 5065048 5065665 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5065048..5065665 Escherichia coli 55989 7145269 YP_002405826.1 CDS EC55989_4980 NC_011748.1 5065837 5066034 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5065837..5066034 Escherichia coli 55989 7145270 YP_002405827.1 CDS EC55989_4981 NC_011748.1 5066866 5067543 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5066866..5067543 Escherichia coli 55989 7145271 YP_002405828.1 CDS EC55989_4982 NC_011748.1 5067554 5068057 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 273224, 375010, 1849492; Product type pe : enzyme; Insertion element IS1 1/5/6 protein InsB complement(5067554..5068057) Escherichia coli 55989 7145272 YP_002405829.1 CDS EC55989_4983 NC_011748.1 5067976 5068251 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1849492; Product type r : regulator; IS1 repressor protein insA complement(5067976..5068251) Escherichia coli 55989 7145273 YP_002405830.1 CDS gntP NC_011748.1 5068650 5069993 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 96125229, 15516583, 8550444; Product type t : transporter; fructuronate transporter complement(5068650..5069993) Escherichia coli 55989 7146111 YP_002405831.1 CDS EC55989_4986 NC_011748.1 5070073 5070381 D Evidence 6 : Doubtful CDS; hypothetical protein 5070073..5070381 Escherichia coli 55989 7146350 YP_002405832.1 CDS uxuA NC_011748.1 5070333 5071517 D catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate; mannonate dehydratase 5070333..5071517 Escherichia coli 55989 7145275 YP_002405833.1 CDS uxuB NC_011748.1 5071598 5073058 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 73203083, 77222076, 14401695; Product type e : enzyme; D-mannonate oxidoreductase, NAD-binding 5071598..5073058 Escherichia coli 55989 7147941 YP_002405834.1 CDS uxuR NC_011748.1 5073273 5074046 D regulates the expression of uxuBA; DNA-binding transcriptional repressor UxuR 5073273..5074046 Escherichia coli 55989 7147942 YP_002405835.1 CDS yjiC NC_011748.1 5074187 5075017 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5074187..5075017) Escherichia coli 55989 7147943 YP_002405836.1 CDS EC55989_4991 NC_011748.1 5075580 5075723 D Evidence 6 : Doubtful CDS; hypothetical protein 5075580..5075723 Escherichia coli 55989 7149208 YP_002405837.1 CDS iraD NC_011748.1 5075689 5076081 D inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS; DNA replication/recombination/repair protein 5075689..5076081 Escherichia coli 55989 7145276 YP_002405838.1 CDS yjiE NC_011748.1 5076074 5076985 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(5076074..5076985) Escherichia coli 55989 7149209 YP_002405839.1 CDS iadA NC_011748.1 5077050 5078222 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 95181377, 7876157; Product type e : enzyme; isoaspartyl dipeptidase complement(5077050..5078222) Escherichia coli 55989 7149210 YP_002405840.1 CDS yjiG NC_011748.1 5078235 5078696 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(5078235..5078696) Escherichia coli 55989 7146529 YP_002405841.1 CDS yjiH NC_011748.1 5078693 5079376 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(5078693..5079376) Escherichia coli 55989 7149211 YP_002405842.1 CDS kptA NC_011748.1 5079626 5080180 D in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown; RNA 2'-phosphotransferase-like protein 5079626..5080180 Escherichia coli 55989 7149212 YP_002405843.1 CDS yjiJ NC_011748.1 5080193 5081371 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(5080193..5081371) Escherichia coli 55989 7146672 YP_002405844.1 CDS yjiK NC_011748.1 5081439 5082299 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; hypothetical protein complement(5081439..5082299) Escherichia coli 55989 7149213 YP_002405845.1 CDS EC55989_5000 NC_011748.1 5082364 5082621 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5082364..5082621) Escherichia coli 55989 7149214 YP_002405846.1 CDS hgdC NC_011748.1 5082618 5083385 R Evidence 2a : Function of homologous gene experimentally demonstrated in an other organism; PubMedId : 8365476, 7607244, 15654892; Product type e : enzyme; ATPase, activator of (R)-hydroxyglutaryl-CoA dehydratase complement(5082618..5083385) Escherichia coli 55989 7145277 YP_002405847.1 CDS yjiM NC_011748.1 5083395 5084546 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 3691501, 11106419; Product type pe : enzyme; 2-hydroxyglutaryl-CoA dehydratase complement(5083395..5084546) Escherichia coli 55989 7146425 YP_002405848.1 CDS yjiN NC_011748.1 5084662 5085942 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(5084662..5085942) Escherichia coli 55989 7149215 YP_002405849.1 CDS yjiO NC_011748.1 5085983 5087215 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 21450803; Product type t : transporter; multidrug efflux system protein complement(5085983..5087215) Escherichia coli 55989 7149216 YP_002405850.1 CDS EC55989_5005 NC_011748.1 5087682 5088638 D Evidence 4 : Homologs of previously reported genes of unknown function; transposase 5087682..5088638 Escherichia coli 55989 7149217 YP_002405851.1 CDS yjiR NC_011748.1 5088881 5090293 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; fused DNA-binding transcriptional regulator ; aminotransferase complement(5088881..5090293) Escherichia coli 55989 7145278 YP_002405852.1 CDS yjiW NC_011748.1 5092871 5093212 R involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response; endoribonuclease SymE complement(5092871..5093212) Escherichia coli 55989 7145280 YP_002405853.1 CDS EC55989_5010 NC_011748.1 5093433 5095169 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9837717, 10733903, 11273713; Product type f : factor; Type I restriction enzyme EcoAI specificity protein (S protein) (S.EcoAI) complement(5093433..5095169) Escherichia coli 55989 7147595 YP_002405854.1 CDS hsdM NC_011748.1 5095169 5096674 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 8412658, 1409708; Product type e : enzyme; Type I restriction enzyme EcoEI M protein (M.EcoEI) complement(5095169..5096674) Escherichia coli 55989 7145281 YP_002405855.1 CDS hsdR NC_011748.1 5096705 5099137 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9837717, 10373579, 10733903, 8412658; Product type e : enzyme; Type I restriction enzyme EcoAI R protein (R.EcoAI) complement(5096705..5099137) Escherichia coli 55989 7146465 YP_002405856.1 CDS EC55989_5013 NC_011748.1 5099394 5101067 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5099394..5101067 Escherichia coli 55989 7146466 YP_002405857.1 CDS yjiA NC_011748.1 5101136 5102092 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; PubMedId : 14696199; Product type pe : enzyme; GTP-binding protein YjiA complement(5101136..5102092) Escherichia coli 55989 7145282 YP_002405858.1 CDS EC55989_5015 NC_011748.1 5102103 5102432 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5102103..5102432) Escherichia coli 55989 7149207 YP_002405859.1 CDS yjiY NC_011748.1 5102437 5104587 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(5102437..5104587) Escherichia coli 55989 7145283 YP_002405860.1 CDS tsr NC_011748.1 5104964 5106628 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20015410, 89034150, 91317710, 10466731, 2033064, 6213619, 6402709, 8384293; Product type r : regulator; methyl-accepting chemotaxis protein I, serine sensor receptor 5104964..5106628 Escherichia coli 55989 7149220 YP_002405861.1 CDS yjiZ NC_011748.1 5106677 5108038 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pt : transporter; transporter complement(5106677..5108038) Escherichia coli 55989 7147867 YP_002405862.1 CDS yjjM NC_011748.1 5108253 5109167 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator complement(5108253..5109167) Escherichia coli 55989 7149221 YP_002405863.1 CDS yjjN NC_011748.1 5109306 5110328 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; oxidoreductase, Zn-dependent and NAD(P)-binding 5109306..5110328 Escherichia coli 55989 7149226 YP_002405864.1 CDS mdoB NC_011748.1 5110469 5112760 R catalyzes the transfer of phosphoglycerol to the glucan backbone; phosphoglycerol transferase I complement(5110469..5112760) Escherichia coli 55989 7149227 YP_002405865.1 CDS yjjA NC_011748.1 5113014 5113508 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5113014..5113508) Escherichia coli 55989 7146797 YP_002405866.1 CDS dnaC NC_011748.1 5113557 5114294 R acts to load the DnaB helicase onto the initiation site during DNA replication; DNA replication protein DnaC complement(5113557..5114294) Escherichia coli 55989 7149222 YP_002405867.1 CDS dnaT NC_011748.1 5114297 5114836 R This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'; primosomal protein DnaI complement(5114297..5114836) Escherichia coli 55989 7145934 YP_002405868.2 CDS EC55989_5025 NC_011748.1 5114943 5115416 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5114943..5115416) Escherichia coli 55989 7145941 YP_002405869.1 CDS yjjP NC_011748.1 5115407 5116177 R Evidence 4 : Homologs of previously reported genes of unknown function; Product type pm : membrane component; inner membrane protein complement(5115407..5116177) Escherichia coli 55989 7145284 YP_002405870.1 CDS yjjQ NC_011748.1 5116798 5117523 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pr : regulator; DNA-binding transcriptional regulator 5116798..5117523 Escherichia coli 55989 7149228 YP_002405871.1 CDS bglJ NC_011748.1 5117535 5118158 D regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin; DNA-binding transcriptional activator BglJ 5117535..5118158 Escherichia coli 55989 7149229 YP_002405872.1 CDS fhuF NC_011748.1 5118196 5118984 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 11931550, 14756576, 3323834, 9990318; Product type c : carrier; ferric hydroximate transport ferric iron reductase complement(5118196..5118984) Escherichia coli 55989 7145622 YP_002405873.1 CDS EC55989_5030 NC_011748.1 5119014 5119361 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5119014..5119361 Escherichia coli 55989 7146104 YP_002405874.1 CDS rsmC NC_011748.1 5120031 5121062 R 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit; 16S ribosomal RNA m2G1207 methyltransferase complement(5120031..5121062) Escherichia coli 55989 7145368 YP_002405875.1 CDS holD NC_011748.1 5121165 5121578 D with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB; DNA polymerase III subunit psi 5121165..5121578 Escherichia coli 55989 7147536 YP_002405876.1 CDS rimI NC_011748.1 5121547 5121993 D alanine acetyltransferase that specifically acetylates ribosomal protein S18; ribosomal-protein-alanine N-acetyltransferase 5121547..5121993 Escherichia coli 55989 7146456 YP_002405877.1 CDS yjjG NC_011748.1 5122008 5122685 D manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily; nucleotidase 5122008..5122685 Escherichia coli 55989 7147418 YP_002405878.1 CDS prfC NC_011748.1 5122776 5124365 D stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein; peptide chain release factor 3 5122776..5124365 Escherichia coli 55989 7149223 YP_002405879.1 CDS osmY NC_011748.1 5124758 5125363 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 1317380, 8253679, 9298646, 9600841; Product type cp : cell process; hypothetical protein 5124758..5125363 Escherichia coli 55989 7147242 YP_002405880.1 CDS ytjA NC_011748.1 5125472 5125651 D Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein 5125472..5125651 Escherichia coli 55989 7147084 YP_002405881.1 CDS yjjU NC_011748.1 5125773 5126846 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; esterase 5125773..5126846 Escherichia coli 55989 7149483 YP_002405882.1 CDS yjjV NC_011748.1 5126843 5127625 D Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; deoxyribonuclease YjjV 5126843..5127625 Escherichia coli 55989 7149230 YP_002405883.1 CDS yjjW NC_011748.1 5127855 5128718 R Evidence 3 : Function proposed based on presence of conserved amino acid motif, structural feature or limited homology; Product type pe : enzyme; pyruvate formate lyase activating enzyme complement(5127855..5128718) Escherichia coli 55989 7149231 YP_002405884.1 CDS yjjI NC_011748.1 5128690 5130240 R Evidence 4 : Homologs of previously reported genes of unknown function; hypothetical protein complement(5128690..5130240) Escherichia coli 55989 7149232 YP_002405885.1 CDS deoC NC_011748.1 5130498 5131277 D catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate; deoxyribose-phosphate aldolase 5130498..5131277 Escherichia coli 55989 7149224 YP_002405886.1 CDS deoA NC_011748.1 5131355 5132677 D Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate; thymidine phosphorylase 5131355..5132677 Escherichia coli 55989 7145884 YP_002405887.1 CDS deoB NC_011748.1 5132729 5133952 D catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose; phosphopentomutase 5132729..5133952 Escherichia coli 55989 7145882 YP_002405888.1 CDS deoD NC_011748.1 5134032 5134751 D catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate; purine nucleoside phosphorylase 5134032..5134751 Escherichia coli 55989 7145883 YP_002405889.1 CDS lplA NC_011748.1 5135207 5136223 R Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins; lipoate-protein ligase A complement(5135207..5136223) Escherichia coli 55989 7145286 YP_002405890.1 CDS ytjB NC_011748.1 5136251 5136895 R Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 2684780; hypothetical protein complement(5136251..5136895) Escherichia coli 55989 7146731 YP_002405891.1 CDS serB NC_011748.1 5137001 5137969 D catalyzes the formation of serine from O-phosphoserine; phosphoserine phosphatase 5137001..5137969 Escherichia coli 55989 7149484 YP_002405892.1 CDS radA NC_011748.1 5138018 5139400 D Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents; DNA repair protein RadA 5138018..5139400 Escherichia coli 55989 7147633 YP_002405893.1 CDS nadR NC_011748.1 5139421 5140653 D catalyzes the formation of NAD(+) from nicotinamide ribonucleotide; nicotinamide-nucleotide adenylyltransferase 5139421..5140653 Escherichia coli 55989 7147335 YP_002405894.1 CDS yjjK NC_011748.1 5140960 5142627 R ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence; ABC transporter ATP-binding protein complement(5140960..5142627) Escherichia coli 55989 7146947 YP_002405895.1 CDS slt NC_011748.1 5142838 5144775 D catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan; lytic murein transglycosylase 5142838..5144775 Escherichia coli 55989 7149225 YP_002405896.1 CDS trpR NC_011748.1 5144865 5145191 D When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription; Trp operon repressor 5144865..5145191 Escherichia coli 55989 7147661 YP_002405897.1 CDS yjjX NC_011748.1 5145233 5145745 R pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog; NTPase complement(5145233..5145745) Escherichia coli 55989 7147856 YP_002405898.1 CDS ytjC NC_011748.1 5145797 5146444 D catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate; phosphoglycerate mutase 5145797..5146444 Escherichia coli 55989 7149233 YP_002405899.1 CDS rob NC_011748.1 5146441 5147310 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 20264525, 20309711, 93194823, 96405618, 8449900; Product type r : regulator; DNA-binding transcriptional activator complement(5146441..5147310) Escherichia coli 55989 7149485 YP_002405900.1 CDS creA NC_011748.1 5147521 5147994 D Evidence 4 : Homologs of previously reported genes of unknown function; PubMedId : 3531171, 8449900; hypothetical protein 5147521..5147994 Escherichia coli 55989 7147457 YP_002405901.1 CDS creB NC_011748.1 5148007 5148696 D response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation; DNA-binding response regulator CreB 5148007..5148696 Escherichia coli 55989 7145753 YP_002405902.1 CDS creC NC_011748.1 5148696 5150120 D part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation; sensory histidine kinase CreC 5148696..5150120 Escherichia coli 55989 7145754 YP_002405903.1 CDS creD NC_011748.1 5150178 5151530 D Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 88216172, 2835585, 2984198, 3531171; Product type m : membrane component; hypothetical protein 5150178..5151530 Escherichia coli 55989 7145755 YP_002405904.1 CDS arcA NC_011748.1 5151590 5152306 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 15028693, 21167794, 21317451, 91008980, 91358353, 92380937, 9514749, 9632255, 2984198, 7565118, 9298646; Product type r : regulator; two-component response regulator complement(5151590..5152306) Escherichia coli 55989 7145756 YP_002405905.1 CDS insI NC_011748.1 5152427 5153578 R Evidence 1b : Function experimentally demonstrated in the studied species; PubMedId : 9689094, 6092059; Product type e : enzyme; IS30 transposase; KpLE2 phage-like element complement(5152427..5153578) Escherichia coli 55989 7145522 YP_002405906.1 CDS yjtD NC_011748.1 5154165 5154851 D member of the SPOUT superfamily of methyltransferases; RNA methyltransferase 5154165..5154851 Escherichia coli 55989 7147433 EC55989_tRNA1 tRNA EC55989_tRNA1 NC_011748.1 225876 225952 D tRNA-Ile 225876..225952 Escherichia coli 55989 7144634 EC55989_tRNA2 tRNA EC55989_tRNA2 NC_011748.1 225995 226070 D tRNA-Ala 225995..226070 Escherichia coli 55989 7145317 EC55989_tRNA3 tRNA EC55989_tRNA3 NC_011748.1 229562 229638 D tRNA-Asp 229562..229638 Escherichia coli 55989 7144364 EC55989_tRNA4 tRNA EC55989_tRNA4 NC_011748.1 239123 239199 D tRNA-Asp 239123..239199 Escherichia coli 55989 7145940 EC55989_tRNA5 tRNA EC55989_tRNA5 NC_011748.1 296227 296302 D tRNA-Thr 296227..296302 Escherichia coli 55989 7147252 EC55989_tRNA6 tRNA EC55989_tRNA6 NC_011748.1 370827 370907 D tRNA-OTHER 370827..370907 Escherichia coli 55989 7148069 EC55989_tRNA7 tRNA EC55989_tRNA7 NC_011748.1 592535 592611 D tRNA-Arg 592535..592611 Escherichia coli 55989 7146112 EC55989_tRNA94 tRNA EC55989_tRNA94 NC_011748.1 714030 714104 R tRNA-Gln complement(714030..714104) Escherichia coli 55989 7147892 EC55989_tRNA93 tRNA EC55989_tRNA93 NC_011748.1 714142 714216 R tRNA-Gln complement(714142..714216) Escherichia coli 55989 7145410 EC55989_tRNA92 tRNA EC55989_tRNA92 NC_011748.1 714265 714341 R tRNA-Met complement(714265..714341) Escherichia coli 55989 7145409 EC55989_tRNA91 tRNA EC55989_tRNA91 NC_011748.1 714357 714431 R tRNA-Gln complement(714357..714431) Escherichia coli 55989 7145408 EC55989_tRNA90 tRNA EC55989_tRNA90 NC_011748.1 714466 714540 R tRNA-Gln complement(714466..714540) Escherichia coli 55989 7145407 EC55989_tRNA89 tRNA EC55989_tRNA89 NC_011748.1 714564 714648 R tRNA-Leu complement(714564..714648) Escherichia coli 55989 7145406 EC55989_tRNA88 tRNA EC55989_tRNA88 NC_011748.1 714657 714733 R tRNA-Met complement(714657..714733) Escherichia coli 55989 7145404 EC55989_tRNA8 tRNA EC55989_tRNA8 NC_011748.1 794636 794711 D tRNA-Lys 794636..794711 Escherichia coli 55989 7148174 EC55989_tRNA9 tRNA EC55989_tRNA9 NC_011748.1 794747 794822 D tRNA-Val 794747..794822 Escherichia coli 55989 7145394 EC55989_tRNA10 tRNA EC55989_tRNA10 NC_011748.1 794825 794900 D tRNA-Lys 794825..794900 Escherichia coli 55989 7145405 EC55989_tRNA11 tRNA EC55989_tRNA11 NC_011748.1 795050 795125 D tRNA-Val 795050..795125 Escherichia coli 55989 7145318 EC55989_tRNA12 tRNA EC55989_tRNA12 NC_011748.1 795129 795204 D tRNA-Lys 795129..795204 Escherichia coli 55989 7145319 EC55989_tRNA13 tRNA EC55989_tRNA13 NC_011748.1 795351 795426 D tRNA-Lys 795351..795426 Escherichia coli 55989 7145320 EC55989_tRNA14 tRNA EC55989_tRNA14 NC_011748.1 795460 795535 D tRNA-Lys 795460..795535 Escherichia coli 55989 7145321 EC55989_tRNA87 tRNA EC55989_tRNA87 NC_011748.1 987236 987323 R tRNA-Ser complement(987236..987323) Escherichia coli 55989 7145722 EC55989_tRNA15 tRNA EC55989_tRNA15 NC_011748.1 1112487 1112562 D tRNA-Met 1112487..1112562 Escherichia coli 55989 7144504 EC55989_tRNA16 tRNA EC55989_tRNA16 NC_011748.1 1112570 1112646 D tRNA-Arg 1112570..1112646 Escherichia coli 55989 7145323 EC55989_tRNA17 tRNA EC55989_tRNA17 NC_011748.1 1112660 1112736 D tRNA-Arg 1112660..1112736 Escherichia coli 55989 7145324 EC55989_tRNA86 tRNA EC55989_tRNA86 NC_011748.1 1140292 1140379 R tRNA-Ser complement(1140292..1140379) Escherichia coli 55989 7144527 EC55989_tRNA85 tRNA EC55989_tRNA85 NC_011748.1 1207704 1207791 R tRNA-Ser complement(1207704..1207791) Escherichia coli 55989 7148285 EC55989_tRNA84 tRNA EC55989_tRNA84 NC_011748.1 1382189 1382273 R tRNA-Tyr complement(1382189..1382273) Escherichia coli 55989 7147556 EC55989_tRNA83 tRNA EC55989_tRNA83 NC_011748.1 1382308 1382392 R tRNA-Tyr complement(1382308..1382392) Escherichia coli 55989 7145399 EC55989_tRNA18 tRNA EC55989_tRNA18 NC_011748.1 1425498 1425573 D tRNA-Met 1425498..1425573 Escherichia coli 55989 7144565 EC55989_tRNA19 tRNA EC55989_tRNA19 NC_011748.1 1425671 1425747 D tRNA-Arg 1425671..1425747 Escherichia coli 55989 7145326 EC55989_tRNA82 tRNA EC55989_tRNA82 NC_011748.1 1786224 1786300 R tRNA-Arg complement(1786224..1786300) Escherichia coli 55989 7144655 EC55989_tRNA81 tRNA EC55989_tRNA81 NC_011748.1 1786401 1786476 R tRNA-Met complement(1786401..1786476) Escherichia coli 55989 7144656 EC55989_tRNA20 tRNA EC55989_tRNA20 NC_011748.1 1895064 1895140 D tRNA-Val 1895064..1895140 Escherichia coli 55989 7148468 EC55989_tRNA21 tRNA EC55989_tRNA21 NC_011748.1 1895145 1895221 D tRNA-Val 1895145..1895221 Escherichia coli 55989 7145329 EC55989_tRNA80 tRNA EC55989_tRNA80 NC_011748.1 2177740 2177826 R tRNA-Leu complement(2177740..2177826) Escherichia coli 55989 7144707 EC55989_tRNA79 tRNA EC55989_tRNA79 NC_011748.1 2177839 2177912 R tRNA-Cys complement(2177839..2177912) Escherichia coli 55989 7145395 EC55989_tRNA78 tRNA EC55989_tRNA78 NC_011748.1 2177967 2178042 R tRNA-Gly complement(2177967..2178042) Escherichia coli 55989 7145393 EC55989_tRNA77 tRNA EC55989_tRNA77 NC_011748.1 2231720 2231809 R tRNA-Ser complement(2231720..2231809) Escherichia coli 55989 7149346 EC55989_tRNA22 tRNA EC55989_tRNA22 NC_011748.1 2232801 2232876 D tRNA-Asn 2232801..2232876 Escherichia coli 55989 7148597 EC55989_tRNA76 tRNA EC55989_tRNA76 NC_011748.1 2272692 2272767 R tRNA-Asn complement(2272692..2272767) Escherichia coli 55989 7148602 EC55989_tRNA23 tRNA EC55989_tRNA23 NC_011748.1 2274516 2274591 D tRNA-Asn 2274516..2274591 Escherichia coli 55989 7148603 EC55989_tRNA24 tRNA EC55989_tRNA24 NC_011748.1 2276925 2277000 D tRNA-Asn 2276925..2277000 Escherichia coli 55989 7146941 EC55989_tRNA25 tRNA EC55989_tRNA25 NC_011748.1 2501611 2501687 D tRNA-Pro 2501611..2501687 Escherichia coli 55989 7148677 EC55989_tRNA26 tRNA EC55989_tRNA26 NC_011748.1 2665282 2665356 D tRNA-Arg 2665282..2665356 Escherichia coli 55989 7148723 EC55989_tRNA75 tRNA EC55989_tRNA75 NC_011748.1 2749070 2749145 R tRNA-Ala complement(2749070..2749145) Escherichia coli 55989 7148730 EC55989_tRNA74 tRNA EC55989_tRNA74 NC_011748.1 2749185 2749260 R tRNA-Ala complement(2749185..2749260) Escherichia coli 55989 7145389 EC55989_tRNA27 tRNA EC55989_tRNA27 NC_011748.1 2751960 2752035 D tRNA-Val 2751960..2752035 Escherichia coli 55989 7146336 EC55989_tRNA28 tRNA EC55989_tRNA28 NC_011748.1 2752080 2752155 D tRNA-Val 2752080..2752155 Escherichia coli 55989 7145336 EC55989_tRNA29 tRNA EC55989_tRNA29 NC_011748.1 2752202 2752277 D tRNA-Val 2752202..2752277 Escherichia coli 55989 7145337 EC55989_tRNA30 tRNA EC55989_tRNA30 NC_011748.1 2752282 2752357 D tRNA-Lys 2752282..2752357 Escherichia coli 55989 7145338 EC55989_tRNA73 tRNA EC55989_tRNA73 NC_011748.1 2952616 2952691 R tRNA-Glu complement(2952616..2952691) Escherichia coli 55989 7144760 EC55989_tRNA72 tRNA EC55989_tRNA72 NC_011748.1 2996377 2996452 R tRNA-Met complement(2996377..2996452) Escherichia coli 55989 7144844 EC55989_tRNA71 tRNA EC55989_tRNA71 NC_011748.1 3028479 3028555 R tRNA-Arg complement(3028479..3028555) Escherichia coli 55989 7149390 EC55989_tRNA70 tRNA EC55989_tRNA70 NC_011748.1 3028754 3028830 R tRNA-Arg complement(3028754..3028830) Escherichia coli 55989 7145385 EC55989_tRNA69 tRNA EC55989_tRNA69 NC_011748.1 3029029 3029105 R tRNA-Arg complement(3029029..3029105) Escherichia coli 55989 7145384 EC55989_tRNA68 tRNA EC55989_tRNA68 NC_011748.1 3029303 3029379 R tRNA-Arg complement(3029303..3029379) Escherichia coli 55989 7145382 EC55989_tRNA67 tRNA EC55989_tRNA67 NC_011748.1 3029383 3029475 R tRNA-Ser complement(3029383..3029475) Escherichia coli 55989 7145381 EC55989_tRNA31 tRNA EC55989_tRNA31 NC_011748.1 3164538 3164614 D tRNA-Met 3164538..3164614 Escherichia coli 55989 7146863 EC55989_tRNA32 tRNA EC55989_tRNA32 NC_011748.1 3164648 3164724 D tRNA-Met 3164648..3164724 Escherichia coli 55989 7145341 EC55989_tRNA33 tRNA EC55989_tRNA33 NC_011748.1 3164757 3164833 D tRNA-Met 3164757..3164833 Escherichia coli 55989 7145342 EC55989_tRNA66 tRNA EC55989_tRNA66 NC_011748.1 3223125 3223198 R tRNA-Gly complement(3223125..3223198) Escherichia coli 55989 7144874 EC55989_tRNA34 tRNA EC55989_tRNA34 NC_011748.1 3339841 3339916 D tRNA-Phe 3339841..3339916 Escherichia coli 55989 7149407 EC55989_tRNA35 tRNA EC55989_tRNA35 NC_011748.1 3564331 3564406 D tRNA-Met 3564331..3564406 Escherichia coli 55989 7148903 EC55989_tRNA65 tRNA EC55989_tRNA65 NC_011748.1 3675608 3675684 R tRNA-Met complement(3675608..3675684) Escherichia coli 55989 7148925 EC55989_tRNA64 tRNA EC55989_tRNA64 NC_011748.1 3679465 3679551 R tRNA-Leu complement(3679465..3679551) Escherichia coli 55989 7148937 EC55989_tRNA63 tRNA EC55989_tRNA63 NC_011748.1 3773210 3773285 R tRNA-Thr complement(3773210..3773285) Escherichia coli 55989 7145288 EC55989_tRNA62 tRNA EC55989_tRNA62 NC_011748.1 3776598 3776673 R tRNA-Ala complement(3776598..3776673) Escherichia coli 55989 7144759 EC55989_tRNA61 tRNA EC55989_tRNA61 NC_011748.1 3776716 3776792 R tRNA-Ile complement(3776716..3776792) Escherichia coli 55989 7145375 EC55989_tRNA60 tRNA EC55989_tRNA60 NC_011748.1 4074901 4074977 R tRNA-Pro complement(4074901..4074977) Escherichia coli 55989 7145944 EC55989_tRNA36 tRNA EC55989_tRNA36 NC_011748.1 4211244 4211334 D tRNA-Sec 4211244..4211334 Escherichia coli 55989 7149055 EC55989_tRNA37 tRNA EC55989_tRNA37 NC_011748.1 4323728 4323803 D tRNA-Glu 4323728..4323803 Escherichia coli 55989 7144635 EC55989_tRNA38 tRNA EC55989_tRNA38 NC_011748.1 4327165 4327241 D tRNA-Asp 4327165..4327241 Escherichia coli 55989 7145291 EC55989_tRNA39 tRNA EC55989_tRNA39 NC_011748.1 4327250 4327325 D tRNA-Trp 4327250..4327325 Escherichia coli 55989 7145348 EC55989_tRNA40 tRNA EC55989_tRNA40 NC_011748.1 4362669 4362745 D tRNA-Arg 4362669..4362745 Escherichia coli 55989 7149090 EC55989_tRNA41 tRNA EC55989_tRNA41 NC_011748.1 4362804 4362879 D tRNA-His 4362804..4362879 Escherichia coli 55989 7145351 EC55989_tRNA42 tRNA EC55989_tRNA42 NC_011748.1 4362900 4362986 D tRNA-Leu 4362900..4362986 Escherichia coli 55989 7145352 EC55989_tRNA43 tRNA EC55989_tRNA43 NC_011748.1 4363029 4363105 D tRNA-Pro 4363029..4363105 Escherichia coli 55989 7145353 EC55989_tRNA44 tRNA EC55989_tRNA44 NC_011748.1 4421008 4421084 D tRNA-Ile 4421008..4421084 Escherichia coli 55989 7144636 EC55989_tRNA45 tRNA EC55989_tRNA45 NC_011748.1 4421127 4421202 D tRNA-Ala 4421127..4421202 Escherichia coli 55989 7145355 EC55989_tRNA46 tRNA EC55989_tRNA46 NC_011748.1 4558231 4558306 D tRNA-Glu 4558231..4558306 Escherichia coli 55989 7144637 EC55989_tRNA47 tRNA EC55989_tRNA47 NC_011748.1 4565247 4565322 D tRNA-Thr 4565247..4565322 Escherichia coli 55989 7145732 EC55989_tRNA48 tRNA EC55989_tRNA48 NC_011748.1 4565331 4565415 D tRNA-Tyr 4565331..4565415 Escherichia coli 55989 7145358 EC55989_tRNA49 tRNA EC55989_tRNA49 NC_011748.1 4565532 4565606 D tRNA-Gly 4565532..4565606 Escherichia coli 55989 7145359 EC55989_tRNA50 tRNA EC55989_tRNA50 NC_011748.1 4565613 4565688 D tRNA-Thr 4565613..4565688 Escherichia coli 55989 7145360 EC55989_tRNA51 tRNA EC55989_tRNA51 NC_011748.1 4599612 4599687 D tRNA-Glu 4599612..4599687 Escherichia coli 55989 7144638 EC55989_tRNA59 tRNA EC55989_tRNA59 NC_011748.1 4808123 4808198 R tRNA-Phe complement(4808123..4808198) Escherichia coli 55989 7145155 EC55989_tRNA52 tRNA EC55989_tRNA52 NC_011748.1 4837926 4838001 D tRNA-Gly 4837926..4838001 Escherichia coli 55989 7147080 EC55989_tRNA53 tRNA EC55989_tRNA53 NC_011748.1 4838038 4838113 D tRNA-Gly 4838038..4838113 Escherichia coli 55989 7145364 EC55989_tRNA54 tRNA EC55989_tRNA54 NC_011748.1 4838149 4838224 D tRNA-Gly 4838149..4838224 Escherichia coli 55989 7145365 EC55989_tRNA55 tRNA EC55989_tRNA55 NC_011748.1 4944183 4944267 D tRNA-Leu 4944183..4944267 Escherichia coli 55989 7145160 EC55989_tRNA58 tRNA EC55989_tRNA58 NC_011748.1 5119400 5119486 R tRNA-Leu complement(5119400..5119486) Escherichia coli 55989 7145285 EC55989_tRNA57 tRNA EC55989_tRNA57 NC_011748.1 5119521 5119607 R tRNA-Leu complement(5119521..5119607) Escherichia coli 55989 7145370 EC55989_tRNA56 tRNA EC55989_tRNA56 NC_011748.1 5119636 5119722 R tRNA-Leu complement(5119636..5119722) Escherichia coli 55989 7145369 EC55989_16S_3 rRNA EC55989_16S_3 NC_011748.1 224266 225807 D ribosomal RNA 16S 224266..225807 Escherichia coli 55989 7146343 EC55989_23S_3 rRNA EC55989_23S_3 NC_011748.1 226254 229157 D ribosomal RNA 23S 226254..229157 Escherichia coli 55989 7145328 EC55989_5S_4 rRNA EC55989_5S_4 NC_011748.1 229251 229370 D ribosomal RNA 5S 229251..229370 Escherichia coli 55989 7144761 EC55989_5S_3 rRNA EC55989_5S_3 NC_011748.1 2949306 2949425 R ribosomal RNA 5S complement(2949306..2949425) Escherichia coli 55989 7146671 EC55989_23S_2 rRNA EC55989_23S_2 NC_011748.1 2949519 2952422 R ribosomal RNA 23S complement(2949519..2952422) Escherichia coli 55989 7145289 EC55989_16S_2 rRNA EC55989_16S_2 NC_011748.1 2952863 2954404 R ribosomal RNA 16S complement(2952863..2954404) Escherichia coli 55989 7145387 EC55989_5S_2 rRNA EC55989_5S_2 NC_011748.1 3773057 3773169 R ribosomal RNA 5S complement(3773057..3773169) Escherichia coli 55989 7145418 EC55989_5S_1 rRNA EC55989_5S_1 NC_011748.1 3773298 3773417 R ribosomal RNA 5S complement(3773298..3773417) Escherichia coli 55989 7145376 EC55989_23S_1 rRNA EC55989_23S_1 NC_011748.1 3773511 3776414 R ribosomal RNA 23S complement(3773511..3776414) Escherichia coli 55989 7145287 EC55989_16S_1 rRNA EC55989_16S_1 NC_011748.1 3776861 3778402 R ribosomal RNA 16S complement(3776861..3778402) Escherichia coli 55989 7145374 EC55989_16S_4 rRNA EC55989_16S_4 NC_011748.1 4322101 4323642 D ribosomal RNA 16S 4322101..4323642 Escherichia coli 55989 7149087 EC55989_23S_4 rRNA EC55989_23S_4 NC_011748.1 4323997 4326900 D ribosomal RNA 23S 4323997..4326900 Escherichia coli 55989 7145347 EC55989_5S_5 rRNA EC55989_5S_5 NC_011748.1 4326993 4327112 D ribosomal RNA 5S 4326993..4327112 Escherichia coli 55989 7144762 EC55989_16S_5 rRNA EC55989_16S_5 NC_011748.1 4419398 4420939 D ribosomal RNA 16S 4419398..4420939 Escherichia coli 55989 7146413 EC55989_23S_5 rRNA EC55989_23S_5 NC_011748.1 4421386 4424288 D ribosomal RNA 23S 4421386..4424288 Escherichia coli 55989 7145356 EC55989_5S_6 rRNA EC55989_5S_6 NC_011748.1 4424382 4424501 D ribosomal RNA 5S 4424382..4424501 Escherichia coli 55989 7144763 EC55989_16S_6 rRNA EC55989_16S_6 NC_011748.1 4556604 4558145 D ribosomal RNA 16S 4556604..4558145 Escherichia coli 55989 7146928 EC55989_23S_6 rRNA EC55989_23S_6 NC_011748.1 4558500 4561403 D ribosomal RNA 23S 4558500..4561403 Escherichia coli 55989 7145357 EC55989_5S_7 rRNA EC55989_5S_7 NC_011748.1 4561496 4561615 D ribosomal RNA 5S 4561496..4561615 Escherichia coli 55989 7144764 EC55989_16S_7 rRNA EC55989_16S_7 NC_011748.1 4597985 4599526 D ribosomal RNA 16S 4597985..4599526 Escherichia coli 55989 7147298 EC55989_23S_7 rRNA EC55989_23S_7 NC_011748.1 4599881 4602784 D ribosomal RNA 23S 4599881..4602784 Escherichia coli 55989 7145363 EC55989_5S_8 rRNA EC55989_5S_8 NC_011748.1 4602877 4602996 D ribosomal RNA 5S 4602877..4602996 Escherichia coli 55989 7144765