-- dump date 20140619_081111 -- class Genbank::misc_feature -- table misc_feature_note -- id note 655817000001 Helix-turn-helix domain; Region: HTH_36; pfam13730 655817000002 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 655817000003 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 655817000004 putative catalytic residues [active] 655817000005 putative nucleotide binding site [chemical binding]; other site 655817000006 putative aspartate binding site [chemical binding]; other site 655817000007 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 655817000008 dimer interface [polypeptide binding]; other site 655817000009 putative threonine allosteric regulatory site; other site 655817000010 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 655817000011 putative threonine allosteric regulatory site; other site 655817000012 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 655817000013 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 655817000014 homoserine kinase; Region: thrB; TIGR00191 655817000015 Protein of unknown function; Region: YhfT; pfam10797 655817000016 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 655817000017 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 655817000018 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 655817000019 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817000020 catalytic residue [active] 655817000021 hypothetical protein; Validated; Region: PRK02101 655817000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 655817000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 655817000024 transaldolase-like protein; Provisional; Region: PTZ00411 655817000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 655817000026 active site 655817000027 dimer interface [polypeptide binding]; other site 655817000028 catalytic residue [active] 655817000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 655817000030 MPT binding site; other site 655817000031 trimer interface [polypeptide binding]; other site 655817000032 hypothetical protein; Provisional; Region: PRK10659 655817000033 hypothetical protein; Provisional; Region: PRK10236 655817000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 655817000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 655817000036 hypothetical protein; Provisional; Region: PRK10154 655817000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 655817000038 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 655817000039 nucleotide binding site [chemical binding]; other site 655817000040 NEF interaction site [polypeptide binding]; other site 655817000041 SBD interface [polypeptide binding]; other site 655817000042 chaperone protein DnaJ; Provisional; Region: PRK10767 655817000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 655817000044 HSP70 interaction site [polypeptide binding]; other site 655817000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 655817000046 substrate binding site [polypeptide binding]; other site 655817000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 655817000048 Zn binding sites [ion binding]; other site 655817000049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 655817000050 dimer interface [polypeptide binding]; other site 655817000051 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 655817000052 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 655817000053 Sulfatase; Region: Sulfatase; pfam00884 655817000054 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 655817000055 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 655817000056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817000057 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 655817000058 putative dimerization interface [polypeptide binding]; other site 655817000059 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 655817000060 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 655817000061 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 655817000062 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 655817000063 active site 655817000064 Riboflavin kinase; Region: Flavokinase; smart00904 655817000065 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 655817000066 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 655817000067 HIGH motif; other site 655817000068 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 655817000069 active site 655817000070 KMSKS motif; other site 655817000071 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 655817000072 tRNA binding surface [nucleotide binding]; other site 655817000073 anticodon binding site; other site 655817000074 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 655817000075 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 655817000076 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 655817000077 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 655817000078 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 655817000079 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 655817000080 nuc_hydro: Nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the respective base. These enzymes vary in their substrate specificity. This group contains eukaryotic, bacterial and archeal...; Region: nuc_hydro; cl00226 655817000081 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 655817000082 tetramer interface [polypeptide binding]; other site 655817000083 active site 655817000084 Protein of unknown function (DUF805); Region: DUF805; pfam05656 655817000085 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 655817000086 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 655817000087 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 655817000088 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 655817000089 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 655817000090 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 655817000091 catalytic site [active] 655817000092 subunit interface [polypeptide binding]; other site 655817000093 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 655817000094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655817000095 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 655817000096 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 655817000097 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655817000098 ATP-grasp domain; Region: ATP-grasp_4; cl17255 655817000099 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 655817000100 IMP binding site; other site 655817000101 dimer interface [polypeptide binding]; other site 655817000102 interdomain contacts; other site 655817000103 partial ornithine binding site; other site 655817000104 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 655817000105 carnitine operon protein CaiE; Provisional; Region: PRK13627 655817000106 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 655817000107 putative trimer interface [polypeptide binding]; other site 655817000108 putative metal binding site [ion binding]; other site 655817000109 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 655817000110 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655817000111 substrate binding site [chemical binding]; other site 655817000112 oxyanion hole (OAH) forming residues; other site 655817000113 trimer interface [polypeptide binding]; other site 655817000114 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 655817000115 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 655817000116 acyl-activating enzyme (AAE) consensus motif; other site 655817000117 putative AMP binding site [chemical binding]; other site 655817000118 putative active site [active] 655817000119 putative CoA binding site [chemical binding]; other site 655817000120 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 655817000121 CoA-transferase family III; Region: CoA_transf_3; pfam02515 655817000122 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 655817000123 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 655817000124 active site 655817000125 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 655817000126 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 655817000127 Ligand binding site [chemical binding]; other site 655817000128 Electron transfer flavoprotein domain; Region: ETF; pfam01012 655817000129 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 655817000130 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 655817000131 Ligand binding site [chemical binding]; other site 655817000132 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 655817000133 putative oxidoreductase FixC; Provisional; Region: PRK10157 655817000134 ferredoxin-like protein FixX; Provisional; Region: PRK15449 655817000135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817000136 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 655817000137 putative substrate translocation pore; other site 655817000138 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 655817000139 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 655817000140 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 655817000141 TrkA-N domain; Region: TrkA_N; pfam02254 655817000142 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 655817000143 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 655817000144 folate binding site [chemical binding]; other site 655817000145 NADP+ binding site [chemical binding]; other site 655817000146 Post-segregation antitoxin CcdA; Region: CcdA; pfam07362 655817000147 CcdB protein; Region: CcdB; pfam01845 655817000148 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 655817000149 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 655817000150 active site 655817000151 metal binding site [ion binding]; metal-binding site 655817000152 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 655817000153 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 655817000154 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 655817000155 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 655817000156 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 655817000157 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 655817000158 SurA N-terminal domain; Region: SurA_N; pfam09312 655817000159 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 655817000160 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 655817000161 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 655817000162 OstA-like protein; Region: OstA; pfam03968 655817000163 Organic solvent tolerance protein; Region: OstA_C; pfam04453 655817000164 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 655817000165 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 655817000166 putative metal binding site [ion binding]; other site 655817000167 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 655817000168 HSP70 interaction site [polypeptide binding]; other site 655817000169 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 655817000170 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 655817000171 active site 655817000172 ATP-dependent helicase HepA; Validated; Region: PRK04914 655817000173 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655817000174 ATP binding site [chemical binding]; other site 655817000175 putative Mg++ binding site [ion binding]; other site 655817000176 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817000177 nucleotide binding region [chemical binding]; other site 655817000178 ATP-binding site [chemical binding]; other site 655817000179 DNA polymerase II; Reviewed; Region: PRK05762 655817000180 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 655817000181 active site 655817000182 catalytic site [active] 655817000183 substrate binding site [chemical binding]; other site 655817000184 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 655817000185 active site 655817000186 metal-binding site 655817000187 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 655817000188 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 655817000189 intersubunit interface [polypeptide binding]; other site 655817000190 active site 655817000191 Zn2+ binding site [ion binding]; other site 655817000192 L-arabinose isomerase; Provisional; Region: PRK02929 655817000193 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 655817000194 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 655817000195 trimer interface [polypeptide binding]; other site 655817000196 putative substrate binding site [chemical binding]; other site 655817000197 putative metal binding site [ion binding]; other site 655817000198 ribulokinase; Provisional; Region: PRK04123 655817000199 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 655817000200 N- and C-terminal domain interface [polypeptide binding]; other site 655817000201 active site 655817000202 MgATP binding site [chemical binding]; other site 655817000203 catalytic site [active] 655817000204 metal binding site [ion binding]; metal-binding site 655817000205 carbohydrate binding site [chemical binding]; other site 655817000206 homodimer interface [polypeptide binding]; other site 655817000207 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 655817000208 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 655817000209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817000210 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817000211 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 655817000212 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 655817000213 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 655817000214 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 655817000215 Walker A/P-loop; other site 655817000216 ATP binding site [chemical binding]; other site 655817000217 Q-loop/lid; other site 655817000218 ABC transporter signature motif; other site 655817000219 Walker B; other site 655817000220 D-loop; other site 655817000221 H-loop/switch region; other site 655817000222 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 655817000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817000224 dimer interface [polypeptide binding]; other site 655817000225 conserved gate region; other site 655817000226 putative PBP binding loops; other site 655817000227 ABC-ATPase subunit interface; other site 655817000228 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817000229 dimer interface [polypeptide binding]; other site 655817000230 conserved gate region; other site 655817000231 putative PBP binding loops; other site 655817000232 ABC-ATPase subunit interface; other site 655817000233 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 655817000234 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 655817000235 transcriptional regulator SgrR; Provisional; Region: PRK13626 655817000236 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 655817000237 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 655817000238 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 655817000239 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 655817000240 substrate binding site [chemical binding]; other site 655817000241 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 655817000242 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 655817000243 substrate binding site [chemical binding]; other site 655817000244 ligand binding site [chemical binding]; other site 655817000245 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 655817000246 tartrate dehydrogenase; Region: TTC; TIGR02089 655817000247 2-isopropylmalate synthase; Validated; Region: PRK00915 655817000248 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 655817000249 active site 655817000250 catalytic residues [active] 655817000251 metal binding site [ion binding]; metal-binding site 655817000252 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 655817000253 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 655817000254 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817000255 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 655817000256 putative substrate binding pocket [chemical binding]; other site 655817000257 putative dimerization interface [polypeptide binding]; other site 655817000258 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 655817000259 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 655817000260 PYR/PP interface [polypeptide binding]; other site 655817000261 dimer interface [polypeptide binding]; other site 655817000262 TPP binding site [chemical binding]; other site 655817000263 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 655817000264 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 655817000265 TPP-binding site [chemical binding]; other site 655817000266 dimer interface [polypeptide binding]; other site 655817000267 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 655817000268 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 655817000269 putative valine binding site [chemical binding]; other site 655817000270 dimer interface [polypeptide binding]; other site 655817000271 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 655817000272 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 655817000273 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817000274 DNA binding site [nucleotide binding] 655817000275 domain linker motif; other site 655817000276 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 655817000277 dimerization interface [polypeptide binding]; other site 655817000278 ligand binding site [chemical binding]; other site 655817000279 mraZ protein; Region: TIGR00242 655817000280 MraZ protein; Region: MraZ; pfam02381 655817000281 MraZ protein; Region: MraZ; pfam02381 655817000282 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 655817000283 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 655817000284 cell division protein FtsL; Provisional; Region: PRK10772 655817000285 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 655817000286 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655817000287 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 655817000288 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 655817000289 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 655817000290 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655817000291 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655817000292 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 655817000293 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 655817000294 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655817000295 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655817000296 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 655817000297 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 655817000298 Mg++ binding site [ion binding]; other site 655817000299 putative catalytic motif [active] 655817000300 putative substrate binding site [chemical binding]; other site 655817000301 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 655817000302 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655817000303 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655817000304 cell division protein FtsW; Provisional; Region: PRK10774 655817000305 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 655817000306 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 655817000307 active site 655817000308 homodimer interface [polypeptide binding]; other site 655817000309 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 655817000310 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 655817000311 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655817000312 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655817000313 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 655817000314 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 655817000315 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 655817000316 cell division protein FtsQ; Provisional; Region: PRK10775 655817000317 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 655817000318 Cell division protein FtsQ; Region: FtsQ; pfam03799 655817000319 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 655817000320 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655817000321 Cell division protein FtsA; Region: FtsA; pfam14450 655817000322 cell division protein FtsZ; Validated; Region: PRK09330 655817000323 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 655817000324 nucleotide binding site [chemical binding]; other site 655817000325 SulA interaction site; other site 655817000326 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 655817000327 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 655817000328 SecA regulator SecM; Provisional; Region: PRK02943 655817000329 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 655817000330 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 655817000331 SEC-C motif; Region: SEC-C; pfam02810 655817000332 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 655817000333 active site 655817000334 8-oxo-dGMP binding site [chemical binding]; other site 655817000335 nudix motif; other site 655817000336 metal binding site [ion binding]; metal-binding site 655817000337 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 655817000338 Helix-turn-helix domain; Region: HTH_28; pfam13518 655817000339 Helix-turn-helix domain; Region: HTH_28; pfam13518 655817000340 Integrase core domain; Region: rve; pfam00665 655817000341 Integrase core domain; Region: rve_2; pfam13333 655817000342 DNA gyrase inhibitor; Reviewed; Region: PRK00418 655817000343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 655817000344 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 655817000345 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 655817000346 CoA-binding site [chemical binding]; other site 655817000347 ATP-binding [chemical binding]; other site 655817000348 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 655817000349 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 655817000350 active site 655817000351 type IV pilin biogenesis protein; Provisional; Region: PRK10573 655817000352 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 655817000353 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 655817000354 hypothetical protein; Provisional; Region: PRK10436 655817000355 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 655817000356 Walker A motif; other site 655817000357 ATP binding site [chemical binding]; other site 655817000358 Walker B motif; other site 655817000359 putative major pilin subunit; Provisional; Region: PRK10574 655817000360 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 655817000361 Pilin (bacterial filament); Region: Pilin; pfam00114 655817000362 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 655817000363 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 655817000364 dimerization interface [polypeptide binding]; other site 655817000365 active site 655817000366 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 655817000367 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 655817000368 amidase catalytic site [active] 655817000369 substrate binding site [chemical binding]; other site 655817000370 Zn binding residues [ion binding]; other site 655817000371 regulatory protein AmpE; Provisional; Region: PRK10987 655817000372 aromatic amino acid transporter; Provisional; Region: PRK10238 655817000373 Protein of unknown function (DUF796); Region: DUF796; cl01226 655817000374 S-type Pyocin; Region: Pyocin_S; pfam06958 655817000375 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 655817000376 active site 655817000377 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 655817000378 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 655817000379 active site 655817000380 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 655817000381 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 655817000382 Transcriptional regulators [Transcription]; Region: FadR; COG2186 655817000383 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817000384 DNA-binding site [nucleotide binding]; DNA binding site 655817000385 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 655817000386 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 655817000387 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 655817000388 dimer interface [polypeptide binding]; other site 655817000389 TPP-binding site [chemical binding]; other site 655817000390 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 655817000391 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 655817000392 E3 interaction surface; other site 655817000393 lipoyl attachment site [posttranslational modification]; other site 655817000394 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 655817000395 E3 interaction surface; other site 655817000396 lipoyl attachment site [posttranslational modification]; other site 655817000397 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 655817000398 E3 interaction surface; other site 655817000399 lipoyl attachment site [posttranslational modification]; other site 655817000400 e3 binding domain; Region: E3_binding; pfam02817 655817000401 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 655817000402 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 655817000403 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 655817000404 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817000405 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 655817000406 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 655817000407 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 655817000408 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 655817000409 substrate binding site [chemical binding]; other site 655817000410 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 655817000411 substrate binding site [chemical binding]; other site 655817000412 ligand binding site [chemical binding]; other site 655817000413 hypothetical protein; Provisional; Region: PRK05248 655817000414 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 655817000415 spermidine synthase; Provisional; Region: PRK00811 655817000416 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817000417 S-adenosylmethionine binding site [chemical binding]; other site 655817000418 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 655817000419 multicopper oxidase; Provisional; Region: PRK10965 655817000420 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 655817000421 Multicopper oxidase; Region: Cu-oxidase; pfam00394 655817000422 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 655817000423 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 655817000424 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 655817000425 Trp docking motif [polypeptide binding]; other site 655817000426 putative active site [active] 655817000427 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655817000428 active site 655817000429 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 655817000430 active site clefts [active] 655817000431 zinc binding site [ion binding]; other site 655817000432 dimer interface [polypeptide binding]; other site 655817000433 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655817000434 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 655817000435 Walker A/P-loop; other site 655817000436 ATP binding site [chemical binding]; other site 655817000437 Q-loop/lid; other site 655817000438 ABC transporter signature motif; other site 655817000439 Walker B; other site 655817000440 D-loop; other site 655817000441 H-loop/switch region; other site 655817000442 inner membrane transport permease; Provisional; Region: PRK15066 655817000443 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 655817000444 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 655817000445 active pocket/dimerization site; other site 655817000446 active site 655817000447 phosphorylation site [posttranslational modification] 655817000448 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 655817000449 putative active site [active] 655817000450 putative metal binding site [ion binding]; other site 655817000451 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 655817000452 tetramerization interface [polypeptide binding]; other site 655817000453 active site 655817000454 Uncharacterized conserved protein [Function unknown]; Region: COG5464 655817000455 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 655817000456 conserved hypothetical protein (putative transposase or invertase); Region: T_den_put_tspse; TIGR01784 655817000457 pantoate--beta-alanine ligase; Region: panC; TIGR00018 655817000458 Pantoate-beta-alanine ligase; Region: PanC; cd00560 655817000459 active site 655817000460 ATP-binding site [chemical binding]; other site 655817000461 pantoate-binding site; other site 655817000462 HXXH motif; other site 655817000463 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 655817000464 oligomerization interface [polypeptide binding]; other site 655817000465 active site 655817000466 metal binding site [ion binding]; metal-binding site 655817000467 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 655817000468 putative fimbrial protein StaF; Provisional; Region: PRK15262 655817000469 putative fimbrial protein StaE; Provisional; Region: PRK15263 655817000470 Fimbrial protein; Region: Fimbrial; cl01416 655817000471 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 655817000472 PapC N-terminal domain; Region: PapC_N; pfam13954 655817000473 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 655817000474 PapC C-terminal domain; Region: PapC_C; pfam13953 655817000475 putative chaperone protein EcpD; Provisional; Region: PRK09926 655817000476 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 655817000477 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 655817000478 Fimbrial protein; Region: Fimbrial; cl01416 655817000479 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 655817000480 catalytic center binding site [active] 655817000481 ATP binding site [chemical binding]; other site 655817000482 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 655817000483 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 655817000484 active site 655817000485 NTP binding site [chemical binding]; other site 655817000486 metal binding triad [ion binding]; metal-binding site 655817000487 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 655817000488 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 655817000489 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 655817000490 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 655817000491 active site 655817000492 nucleotide binding site [chemical binding]; other site 655817000493 HIGH motif; other site 655817000494 KMSKS motif; other site 655817000495 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 655817000496 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 655817000497 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 655817000498 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655817000499 ATP binding site [chemical binding]; other site 655817000500 putative Mg++ binding site [ion binding]; other site 655817000501 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817000502 nucleotide binding region [chemical binding]; other site 655817000503 ATP-binding site [chemical binding]; other site 655817000504 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 655817000505 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 655817000506 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 655817000507 Transglycosylase; Region: Transgly; pfam00912 655817000508 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 655817000509 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 655817000510 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817000511 N-terminal plug; other site 655817000512 ligand-binding site [chemical binding]; other site 655817000513 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 655817000514 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655817000515 Walker A/P-loop; other site 655817000516 ATP binding site [chemical binding]; other site 655817000517 Q-loop/lid; other site 655817000518 ABC transporter signature motif; other site 655817000519 Walker B; other site 655817000520 D-loop; other site 655817000521 H-loop/switch region; other site 655817000522 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 655817000523 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 655817000524 siderophore binding site; other site 655817000525 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 655817000526 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817000527 ABC-ATPase subunit interface; other site 655817000528 dimer interface [polypeptide binding]; other site 655817000529 putative PBP binding regions; other site 655817000530 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817000531 ABC-ATPase subunit interface; other site 655817000532 dimer interface [polypeptide binding]; other site 655817000533 putative PBP binding regions; other site 655817000534 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 655817000535 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655817000536 inhibitor-cofactor binding pocket; inhibition site 655817000537 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817000538 catalytic residue [active] 655817000539 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 655817000540 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 655817000541 Cl- selectivity filter; other site 655817000542 Cl- binding residues [ion binding]; other site 655817000543 pore gating glutamate residue; other site 655817000544 dimer interface [polypeptide binding]; other site 655817000545 H+/Cl- coupling transport residue; other site 655817000546 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 655817000547 hypothetical protein; Provisional; Region: PRK10578 655817000548 UPF0126 domain; Region: UPF0126; pfam03458 655817000549 UPF0126 domain; Region: UPF0126; pfam03458 655817000550 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 655817000551 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 655817000552 cobalamin binding residues [chemical binding]; other site 655817000553 putative BtuC binding residues; other site 655817000554 dimer interface [polypeptide binding]; other site 655817000555 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 655817000556 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 655817000557 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 655817000558 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655817000559 Zn2+ binding site [ion binding]; other site 655817000560 Mg2+ binding site [ion binding]; other site 655817000561 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 655817000562 serine endoprotease; Provisional; Region: PRK10942 655817000563 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 655817000564 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655817000565 protein binding site [polypeptide binding]; other site 655817000566 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655817000567 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 655817000568 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 655817000569 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 655817000570 hypothetical protein; Provisional; Region: PRK13677 655817000571 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 655817000572 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 655817000573 trimer interface [polypeptide binding]; other site 655817000574 active site 655817000575 substrate binding site [chemical binding]; other site 655817000576 CoA binding site [chemical binding]; other site 655817000577 PII uridylyl-transferase; Provisional; Region: PRK05007 655817000578 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 655817000579 metal binding triad; other site 655817000580 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 655817000581 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655817000582 Zn2+ binding site [ion binding]; other site 655817000583 Mg2+ binding site [ion binding]; other site 655817000584 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 655817000585 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 655817000586 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 655817000587 active site 655817000588 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 655817000589 rRNA interaction site [nucleotide binding]; other site 655817000590 S8 interaction site; other site 655817000591 putative laminin-1 binding site; other site 655817000592 elongation factor Ts; Provisional; Region: tsf; PRK09377 655817000593 UBA/TS-N domain; Region: UBA; pfam00627 655817000594 Elongation factor TS; Region: EF_TS; pfam00889 655817000595 Elongation factor TS; Region: EF_TS; pfam00889 655817000596 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 655817000597 putative nucleotide binding site [chemical binding]; other site 655817000598 uridine monophosphate binding site [chemical binding]; other site 655817000599 homohexameric interface [polypeptide binding]; other site 655817000600 ribosome recycling factor; Reviewed; Region: frr; PRK00083 655817000601 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 655817000602 hinge region; other site 655817000603 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 655817000604 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 655817000605 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 655817000606 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 655817000607 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 655817000608 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 655817000609 catalytic residue [active] 655817000610 putative FPP diphosphate binding site; other site 655817000611 putative FPP binding hydrophobic cleft; other site 655817000612 dimer interface [polypeptide binding]; other site 655817000613 putative IPP diphosphate binding site; other site 655817000614 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 655817000615 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 655817000616 zinc metallopeptidase RseP; Provisional; Region: PRK10779 655817000617 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 655817000618 active site 655817000619 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 655817000620 protein binding site [polypeptide binding]; other site 655817000621 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 655817000622 putative substrate binding region [chemical binding]; other site 655817000623 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 655817000624 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 655817000625 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 655817000626 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 655817000627 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 655817000628 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 655817000629 Surface antigen; Region: Bac_surface_Ag; pfam01103 655817000630 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 655817000631 periplasmic chaperone; Provisional; Region: PRK10780 655817000632 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 655817000633 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 655817000634 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 655817000635 trimer interface [polypeptide binding]; other site 655817000636 active site 655817000637 UDP-GlcNAc binding site [chemical binding]; other site 655817000638 lipid binding site [chemical binding]; lipid-binding site 655817000639 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 655817000640 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 655817000641 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 655817000642 active site 655817000643 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 655817000644 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 655817000645 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 655817000646 RNA/DNA hybrid binding site [nucleotide binding]; other site 655817000647 active site 655817000648 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 655817000649 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 655817000650 putative active site [active] 655817000651 putative PHP Thumb interface [polypeptide binding]; other site 655817000652 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 655817000653 generic binding surface II; other site 655817000654 generic binding surface I; other site 655817000655 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 655817000656 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 655817000657 lysine decarboxylase LdcC; Provisional; Region: PRK15399 655817000658 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 655817000659 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 655817000660 homodimer interface [polypeptide binding]; other site 655817000661 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817000662 catalytic residue [active] 655817000663 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 655817000664 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 655817000665 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655817000666 putative metal binding site [ion binding]; other site 655817000667 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 655817000668 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 655817000669 Ligand Binding Site [chemical binding]; other site 655817000670 TilS substrate binding domain; Region: TilS; pfam09179 655817000671 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 655817000672 Modulator of Rho-dependent transcription termination (ROF); Region: ROF; cl09210 655817000673 hypothetical protein; Provisional; Region: PRK04964 655817000674 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 655817000675 hypothetical protein; Provisional; Region: PRK09256 655817000676 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 655817000677 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 655817000678 NlpE N-terminal domain; Region: NlpE; pfam04170 655817000679 Integrase core domain; Region: rve; pfam00665 655817000680 Integrase core domain; Region: rve_2; pfam13333 655817000681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 655817000682 Helix-turn-helix domain; Region: HTH_28; pfam13518 655817000683 Helix-turn-helix domain; Region: HTH_28; pfam13518 655817000684 hypothetical protein; Provisional; Region: PRK11479 655817000685 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 655817000686 prolyl-tRNA synthetase; Provisional; Region: PRK09194 655817000687 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 655817000688 dimer interface [polypeptide binding]; other site 655817000689 motif 1; other site 655817000690 active site 655817000691 motif 2; other site 655817000692 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 655817000693 putative deacylase active site [active] 655817000694 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 655817000695 active site 655817000696 motif 3; other site 655817000697 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 655817000698 anticodon binding site; other site 655817000699 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 655817000700 homodimer interaction site [polypeptide binding]; other site 655817000701 cofactor binding site; other site 655817000702 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 655817000703 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 655817000704 lipoprotein, YaeC family; Region: TIGR00363 655817000705 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817000706 dimer interface [polypeptide binding]; other site 655817000707 conserved gate region; other site 655817000708 ABC-ATPase subunit interface; other site 655817000709 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 655817000710 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 655817000711 Walker A/P-loop; other site 655817000712 ATP binding site [chemical binding]; other site 655817000713 Q-loop/lid; other site 655817000714 ABC transporter signature motif; other site 655817000715 Walker B; other site 655817000716 D-loop; other site 655817000717 H-loop/switch region; other site 655817000718 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 655817000719 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 655817000720 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817000721 active site 655817000722 motif I; other site 655817000723 motif II; other site 655817000724 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655817000725 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655817000726 active site 655817000727 catalytic tetrad [active] 655817000728 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655817000729 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817000730 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 655817000731 putative effector binding pocket; other site 655817000732 dimerization interface [polypeptide binding]; other site 655817000733 hypothetical protein; Provisional; Region: PRK05421 655817000734 putative catalytic site [active] 655817000735 putative metal binding site [ion binding]; other site 655817000736 putative phosphate binding site [ion binding]; other site 655817000737 putative catalytic site [active] 655817000738 putative phosphate binding site [ion binding]; other site 655817000739 putative metal binding site [ion binding]; other site 655817000740 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817000741 S-adenosylmethionine binding site [chemical binding]; other site 655817000742 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 655817000743 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 655817000744 N-acetyl-D-glucosamine binding site [chemical binding]; other site 655817000745 catalytic residue [active] 655817000746 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655817000747 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655817000748 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 655817000749 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817000750 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 655817000751 RNA/DNA hybrid binding site [nucleotide binding]; other site 655817000752 active site 655817000753 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 655817000754 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 655817000755 active site 655817000756 catalytic site [active] 655817000757 substrate binding site [chemical binding]; other site 655817000758 Methyltransferase domain; Region: Methyltransf_27; pfam13708 655817000759 Methyltransferase domain; Region: Methyltransf_27; pfam13708 655817000760 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 655817000761 Transposase; Region: HTH_Tnp_1; pfam01527 655817000762 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 655817000763 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 655817000764 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 655817000765 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 655817000766 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 655817000767 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 655817000768 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 655817000769 Transposase; Region: DEDD_Tnp_IS110; pfam01548 655817000770 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 655817000771 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 655817000772 Homeodomain-like domain; Region: HTH_23; pfam13384 655817000773 Winged helix-turn helix; Region: HTH_29; pfam13551 655817000774 Homeodomain-like domain; Region: HTH_32; pfam13565 655817000775 DDE superfamily endonuclease; Region: DDE_3; pfam13358 655817000776 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 655817000777 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 655817000778 Protein of unknown function (DUF987); Region: DUF987; pfam06174 655817000779 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 655817000780 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 655817000781 MPN+ (JAMM) motif; other site 655817000782 Zinc-binding site [ion binding]; other site 655817000783 Antirestriction protein; Region: Antirestrict; pfam03230 655817000784 Domain of unknown function (DUF932); Region: DUF932; pfam06067 655817000785 Photosystem II protein; Region: PSII; cl08223 655817000786 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 655817000787 nucleophile elbow; other site 655817000788 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 655817000789 YjcZ-like protein; Region: YjcZ; pfam13990 655817000790 hypothetical protein; Provisional; Region: PRK09866 655817000791 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 655817000792 G1 box; other site 655817000793 GTP/Mg2+ binding site [chemical binding]; other site 655817000794 G2 box; other site 655817000795 Switch I region; other site 655817000796 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 655817000797 G3 box; other site 655817000798 Switch II region; other site 655817000799 GTP/Mg2+ binding site [chemical binding]; other site 655817000800 G4 box; other site 655817000801 G5 box; other site 655817000802 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 655817000803 G1 box; other site 655817000804 GTP/Mg2+ binding site [chemical binding]; other site 655817000805 G2 box; other site 655817000806 Switch I region; other site 655817000807 Switch II region; other site 655817000808 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 655817000809 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 655817000810 active site 655817000811 DNA binding site [nucleotide binding] 655817000812 Int/Topo IB signature motif; other site 655817000813 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 655817000814 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817000815 N-terminal plug; other site 655817000816 ligand-binding site [chemical binding]; other site 655817000817 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 655817000818 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 655817000819 putative ligand binding residues [chemical binding]; other site 655817000820 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817000821 dimer interface [polypeptide binding]; other site 655817000822 putative PBP binding regions; other site 655817000823 ABC-ATPase subunit interface; other site 655817000824 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 655817000825 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655817000826 Walker A/P-loop; other site 655817000827 ATP binding site [chemical binding]; other site 655817000828 Q-loop/lid; other site 655817000829 ABC transporter signature motif; other site 655817000830 Walker B; other site 655817000831 D-loop; other site 655817000832 H-loop/switch region; other site 655817000833 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 655817000834 Haemolysin expression modulating protein; Region: HHA; cl11501 655817000835 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 655817000836 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 655817000837 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 655817000838 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 655817000839 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 655817000840 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 655817000841 hypothetical protein; Provisional; Region: PRK09273 655817000842 Ribose 5-phosphate isomerase RpiB [Carbohydrate transport and metabolism]; Region: RpiB; COG0698 655817000843 Ribose-5-phosphate isomerase; Region: DUF3666; pfam12408 655817000844 Periplasmic component of the Tol biopolymer transport system [Intracellular trafficking and secretion]; Region: TolB; COG0823 655817000845 gluconate 5-dehydrogenase; Provisional; Region: PRK07097 655817000846 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 655817000847 NADP binding site [chemical binding]; other site 655817000848 homodimer interface [polypeptide binding]; other site 655817000849 active site 655817000850 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 655817000851 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 655817000852 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 655817000853 Right handed beta helix region; Region: Beta_helix; pfam13229 655817000854 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 655817000855 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 655817000856 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 655817000857 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; cl17531 655817000858 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817000859 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655817000860 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 655817000861 substrate binding site [chemical binding]; other site 655817000862 dimer interface [polypeptide binding]; other site 655817000863 ATP binding site [chemical binding]; other site 655817000864 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 655817000865 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817000866 putative substrate translocation pore; other site 655817000867 deoxyribose mutarotase_like; Region: deoxyribose_mutarotase; cd09269 655817000868 active site 655817000869 catalytic residues [active] 655817000870 Transposase; Region: HTH_Tnp_1; cl17663 655817000871 Transposase; Region: HTH_Tnp_1; pfam01527 655817000872 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 655817000873 PTS system ascorbate-specific transporter subunit IIC; Reviewed; Region: ulaA; PRK09410 655817000874 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 655817000875 active site 655817000876 P-loop; other site 655817000877 phosphorylation site [posttranslational modification] 655817000878 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655817000879 active site 655817000880 phosphorylation site [posttranslational modification] 655817000881 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655817000882 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817000883 DNA binding site [nucleotide binding] 655817000884 domain linker motif; other site 655817000885 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 655817000886 putative dimerization interface [polypeptide binding]; other site 655817000887 putative ligand binding site [chemical binding]; other site 655817000888 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 655817000889 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 655817000890 Haemolysin secretion/activation protein ShlB/FhaC/HecB; Region: ShlB; pfam03865 655817000891 haemagglutination activity domain; Region: Haemagg_act; pfam05860 655817000892 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 655817000893 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 655817000894 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 655817000895 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 655817000896 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3328 655817000897 MULE transposase domain; Region: MULE; pfam10551 655817000898 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 655817000899 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 655817000900 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 655817000901 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 655817000902 Autotransporter beta-domain; Region: Autotransporter; pfam03797 655817000903 Transposase; Region: DDE_Tnp_ISL3; pfam01610 655817000904 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 655817000905 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 655817000906 Transposase; Region: DDE_Tnp_ISL3; pfam01610 655817000907 type I secretion outer membrane protein, TolC family; Region: type_I_sec_TolC; TIGR01844 655817000908 type I secretion system ATPase, LssB family; Region: type_I_sec_LssB; TIGR03375 655817000909 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cl00296 655817000910 putative active site [active] 655817000911 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655817000912 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817000913 Walker A/P-loop; other site 655817000914 ATP binding site [chemical binding]; other site 655817000915 Q-loop/lid; other site 655817000916 ABC transporter signature motif; other site 655817000917 Walker B; other site 655817000918 D-loop; other site 655817000919 H-loop/switch region; other site 655817000920 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 655817000921 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817000922 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817000923 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 655817000924 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655817000925 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817000926 DNA binding residues [nucleotide binding] 655817000927 dimerization interface [polypeptide binding]; other site 655817000928 potential frameshift: common BLAST hit: gi|110642861|ref|YP_670591.1| transposase 655817000929 DDE superfamily endonuclease; Region: DDE_3; pfam13358 655817000930 Homeodomain-like domain; Region: HTH_23; pfam13384 655817000931 Winged helix-turn helix; Region: HTH_29; pfam13551 655817000932 Winged helix-turn helix; Region: HTH_33; pfam13592 655817000933 integrating conjugative element protein, PFL_4695 family; Region: ICE_PFL_4695; TIGR03765 655817000934 C-N hydrolase family amidase; Provisional; Region: PRK10438 655817000935 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 655817000936 putative active site [active] 655817000937 catalytic triad [active] 655817000938 dimer interface [polypeptide binding]; other site 655817000939 multimer interface [polypeptide binding]; other site 655817000940 C-lysozyme inhibitor; Provisional; Region: PRK09993 655817000941 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 655817000942 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 655817000943 active site 655817000944 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 655817000945 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 655817000946 dimer interface [polypeptide binding]; other site 655817000947 active site 655817000948 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 655817000949 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 655817000950 putative active site [active] 655817000951 putative dimer interface [polypeptide binding]; other site 655817000952 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 655817000953 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 655817000954 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 655817000955 NlpC/P60 family; Region: NLPC_P60; pfam00877 655817000956 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 655817000957 FHIPEP family; Region: FHIPEP; pfam00771 655817000958 hypothetical protein; Validated; Region: PRK06778 655817000959 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 655817000960 ligand binding site [chemical binding]; other site 655817000961 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 655817000962 active site 655817000963 DNA polymerase IV; Validated; Region: PRK02406 655817000964 DNA binding site [nucleotide binding] 655817000965 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 655817000966 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655817000967 Coenzyme A binding pocket [chemical binding]; other site 655817000968 hypothetical protein; Reviewed; Region: PRK09588 655817000969 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 655817000970 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 655817000971 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 655817000972 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 655817000973 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 655817000974 metal binding site [ion binding]; metal-binding site 655817000975 dimer interface [polypeptide binding]; other site 655817000976 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655817000977 active site 655817000978 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 655817000979 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 655817000980 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 655817000981 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 655817000982 trimer interface [polypeptide binding]; other site 655817000983 eyelet of channel; other site 655817000984 gamma-glutamyl kinase; Provisional; Region: PRK05429 655817000985 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 655817000986 nucleotide binding site [chemical binding]; other site 655817000987 homotetrameric interface [polypeptide binding]; other site 655817000988 putative phosphate binding site [ion binding]; other site 655817000989 putative allosteric binding site; other site 655817000990 PUA domain; Region: PUA; pfam01472 655817000991 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 655817000992 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 655817000993 putative catalytic cysteine [active] 655817000994 integrase; Provisional; Region: PRK09692 655817000995 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 655817000996 active site 655817000997 Int/Topo IB signature motif; other site 655817000998 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 655817000999 AntA/AntB antirepressor; Region: AntA; pfam08346 655817001000 Ash protein family; Region: Phage_ASH; pfam10554 655817001001 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to PFK family that includes ATP- and pyrophosphate (PPi)- dependent phosphofructokinases; Region: PFK; cl00204 655817001002 Kinase binding protein CGI-121; Region: CGI-121; cl00698 655817001003 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 655817001004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 655817001005 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 655817001006 active site 655817001007 metal binding site [ion binding]; metal-binding site 655817001008 interdomain interaction site; other site 655817001009 Superfamily II helicase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG5519 655817001010 Protein of unknown function (DUF2824); Region: DUF2824; cl10279 655817001011 Domain of unknown function (DUF4102); Region: DUF4102; pfam13356 655817001012 MarR family; Region: MarR_2; cl17246 655817001013 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655817001014 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 655817001015 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 655817001016 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 655817001017 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 655817001018 Autotransporter beta-domain; Region: Autotransporter; pfam03797 655817001019 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 655817001020 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 655817001021 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 655817001022 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 655817001023 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 655817001024 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 655817001025 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 655817001026 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 655817001027 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 655817001028 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655817001029 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817001030 DNA binding residues [nucleotide binding] 655817001031 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 655817001032 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 655817001033 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 655817001034 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 655817001035 putative active site [active] 655817001036 putative FMN binding site [chemical binding]; other site 655817001037 putative substrate binding site [chemical binding]; other site 655817001038 putative catalytic residue [active] 655817001039 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 655817001040 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655817001041 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817001042 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 655817001043 putative effector binding pocket; other site 655817001044 putative dimerization interface [polypeptide binding]; other site 655817001045 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655817001046 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817001047 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 655817001048 putative effector binding pocket; other site 655817001049 putative dimerization interface [polypeptide binding]; other site 655817001050 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655817001051 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655817001052 active site 655817001053 catalytic tetrad [active] 655817001054 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655817001055 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655817001056 active site 655817001057 catalytic tetrad [active] 655817001058 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 655817001059 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 655817001060 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 655817001061 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 655817001062 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 655817001063 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 655817001064 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817001065 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 655817001066 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655817001067 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655817001068 active site 655817001069 catalytic tetrad [active] 655817001070 Predicted membrane protein [Function unknown]; Region: COG3059 655817001071 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 655817001072 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 655817001073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817001074 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 655817001075 Cupin; Region: Cupin_6; pfam12852 655817001076 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 655817001077 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817001078 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 655817001079 Cysteine-rich domain; Region: CCG; pfam02754 655817001080 Cysteine-rich domain; Region: CCG; pfam02754 655817001081 iron-sulfur cluster-binding protein; Region: TIGR00273 655817001082 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 655817001083 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 655817001084 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 655817001085 Uncharacterized conserved protein [Function unknown]; Region: COG1556 655817001086 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 655817001087 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 655817001088 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 655817001089 Autotransporter beta-domain; Region: Autotransporter; pfam03797 655817001090 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655817001091 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817001092 DNA binding residues [nucleotide binding] 655817001093 dimerization interface [polypeptide binding]; other site 655817001094 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 655817001095 active site 655817001096 DNA binding site [nucleotide binding] 655817001097 Int/Topo IB signature motif; other site 655817001098 choline dehydrogenase; Validated; Region: PRK02106 655817001099 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 655817001100 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 655817001101 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 655817001102 tetrameric interface [polypeptide binding]; other site 655817001103 NAD binding site [chemical binding]; other site 655817001104 catalytic residues [active] 655817001105 transcriptional regulator BetI; Validated; Region: PRK00767 655817001106 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817001107 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 655817001108 choline transport protein BetT; Provisional; Region: PRK09928 655817001109 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817001110 DNA binding residues [nucleotide binding] 655817001111 dimerization interface [polypeptide binding]; other site 655817001112 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817001113 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 655817001114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817001115 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655817001116 dimerization interface [polypeptide binding]; other site 655817001117 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 655817001118 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 655817001119 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 655817001120 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 655817001121 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 655817001122 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 655817001123 CoA binding domain; Region: CoA_binding; pfam02629 655817001124 CoA-ligase; Region: Ligase_CoA; pfam00549 655817001125 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 655817001126 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 655817001127 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 655817001128 putative substrate binding site [chemical binding]; other site 655817001129 nucleotide binding site [chemical binding]; other site 655817001130 nucleotide binding site [chemical binding]; other site 655817001131 homodimer interface [polypeptide binding]; other site 655817001132 putative deaminase; Validated; Region: PRK06846 655817001133 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 655817001134 active site 655817001135 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 655817001136 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 655817001137 putative NAD(P) binding site [chemical binding]; other site 655817001138 putative substrate binding site [chemical binding]; other site 655817001139 catalytic Zn binding site [ion binding]; other site 655817001140 structural Zn binding site [ion binding]; other site 655817001141 dimer interface [polypeptide binding]; other site 655817001142 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 655817001143 hypothetical protein; Provisional; Region: PRK09929 655817001144 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 655817001145 Propionate catabolism activator; Region: PrpR_N; pfam06506 655817001146 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817001147 Walker A motif; other site 655817001148 ATP binding site [chemical binding]; other site 655817001149 Walker B motif; other site 655817001150 arginine finger; other site 655817001151 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 655817001152 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 655817001153 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 655817001154 tetramer interface [polypeptide binding]; other site 655817001155 active site 655817001156 Mg2+/Mn2+ binding site [ion binding]; other site 655817001157 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 655817001158 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 655817001159 dimer interface [polypeptide binding]; other site 655817001160 active site 655817001161 citrylCoA binding site [chemical binding]; other site 655817001162 oxalacetate/citrate binding site [chemical binding]; other site 655817001163 coenzyme A binding site [chemical binding]; other site 655817001164 catalytic triad [active] 655817001165 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 655817001166 2-methylcitrate dehydratase; Region: prpD; TIGR02330 655817001167 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 655817001168 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 655817001169 acyl-activating enzyme (AAE) consensus motif; other site 655817001170 putative AMP binding site [chemical binding]; other site 655817001171 putative active site [active] 655817001172 putative CoA binding site [chemical binding]; other site 655817001173 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 655817001174 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 655817001175 Na binding site [ion binding]; other site 655817001176 putative substrate binding site [chemical binding]; other site 655817001177 cytosine deaminase; Provisional; Region: PRK09230 655817001178 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 655817001179 active site 655817001180 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 655817001181 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 655817001182 active site 655817001183 substrate binding site [chemical binding]; other site 655817001184 trimer interface [polypeptide binding]; other site 655817001185 CoA binding site [chemical binding]; other site 655817001186 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 655817001187 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817001188 putative substrate translocation pore; other site 655817001189 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 655817001190 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 655817001191 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 655817001192 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 655817001193 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 655817001194 lac repressor; Reviewed; Region: lacI; PRK09526 655817001195 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817001196 DNA binding site [nucleotide binding] 655817001197 domain linker motif; other site 655817001198 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 655817001199 ligand binding site [chemical binding]; other site 655817001200 dimerization interface (open form) [polypeptide binding]; other site 655817001201 dimerization interface (closed form) [polypeptide binding]; other site 655817001202 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 655817001203 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 655817001204 S-formylglutathione hydrolase; Region: PLN02442 655817001205 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 655817001206 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 655817001207 substrate binding site [chemical binding]; other site 655817001208 catalytic Zn binding site [ion binding]; other site 655817001209 NAD binding site [chemical binding]; other site 655817001210 structural Zn binding site [ion binding]; other site 655817001211 dimer interface [polypeptide binding]; other site 655817001212 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 655817001213 putative metal binding site [ion binding]; other site 655817001214 putative homodimer interface [polypeptide binding]; other site 655817001215 putative homotetramer interface [polypeptide binding]; other site 655817001216 putative homodimer-homodimer interface [polypeptide binding]; other site 655817001217 putative allosteric switch controlling residues; other site 655817001218 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 655817001219 putative trimer interface [polypeptide binding]; other site 655817001220 putative CoA binding site [chemical binding]; other site 655817001221 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 655817001222 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 655817001223 DXD motif; other site 655817001224 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 655817001225 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 655817001226 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817001227 substrate binding pocket [chemical binding]; other site 655817001228 membrane-bound complex binding site; other site 655817001229 hinge residues; other site 655817001230 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 655817001231 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 655817001232 Walker A/P-loop; other site 655817001233 ATP binding site [chemical binding]; other site 655817001234 Q-loop/lid; other site 655817001235 ABC transporter signature motif; other site 655817001236 Walker B; other site 655817001237 D-loop; other site 655817001238 H-loop/switch region; other site 655817001239 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 655817001240 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817001241 dimer interface [polypeptide binding]; other site 655817001242 conserved gate region; other site 655817001243 putative PBP binding loops; other site 655817001244 ABC-ATPase subunit interface; other site 655817001245 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 655817001246 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 655817001247 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 655817001248 dimer interface [polypeptide binding]; other site 655817001249 active site 655817001250 Schiff base residues; other site 655817001251 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 655817001252 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 655817001253 Autotransporter beta-domain; Region: Autotransporter; pfam03797 655817001254 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 655817001255 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 655817001256 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 655817001257 microcin B17 transporter; Reviewed; Region: PRK11098 655817001258 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 655817001259 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 655817001260 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 655817001261 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 655817001262 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 655817001263 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 655817001264 anti-RssB factor; Provisional; Region: PRK10244 655817001265 alkaline phosphatase; Provisional; Region: PRK10518 655817001266 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 655817001267 dimer interface [polypeptide binding]; other site 655817001268 active site 655817001269 hypothetical protein; Provisional; Region: PRK11505 655817001270 psiF repeat; Region: PsiF_repeat; pfam07769 655817001271 psiF repeat; Region: PsiF_repeat; pfam07769 655817001272 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 655817001273 MASE2 domain; Region: MASE2; pfam05230 655817001274 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817001275 metal binding site [ion binding]; metal-binding site 655817001276 active site 655817001277 I-site; other site 655817001278 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 655817001279 pyrroline-5-carboxylate reductase; Region: PLN02688 655817001280 hypothetical protein; Validated; Region: PRK00124 655817001281 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 655817001282 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 655817001283 ADP binding site [chemical binding]; other site 655817001284 magnesium binding site [ion binding]; other site 655817001285 putative shikimate binding site; other site 655817001286 hypothetical protein; Provisional; Region: PRK10380 655817001287 hypothetical protein; Provisional; Region: PRK10481 655817001288 hypothetical protein; Provisional; Region: PRK10579 655817001289 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 655817001290 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 655817001291 fructokinase; Reviewed; Region: PRK09557 655817001292 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655817001293 nucleotide binding site [chemical binding]; other site 655817001294 MFS transport protein AraJ; Provisional; Region: PRK10091 655817001295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817001296 putative substrate translocation pore; other site 655817001297 exonuclease subunit SbcC; Provisional; Region: PRK10246 655817001298 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817001299 Walker A/P-loop; other site 655817001300 ATP binding site [chemical binding]; other site 655817001301 Q-loop/lid; other site 655817001302 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817001303 ABC transporter signature motif; other site 655817001304 Walker B; other site 655817001305 D-loop; other site 655817001306 H-loop/switch region; other site 655817001307 exonuclease subunit SbcD; Provisional; Region: PRK10966 655817001308 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 655817001309 active site 655817001310 metal binding site [ion binding]; metal-binding site 655817001311 DNA binding site [nucleotide binding] 655817001312 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 655817001313 transcriptional regulator PhoB; Provisional; Region: PRK10161 655817001314 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817001315 active site 655817001316 phosphorylation site [posttranslational modification] 655817001317 intermolecular recognition site; other site 655817001318 dimerization interface [polypeptide binding]; other site 655817001319 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817001320 DNA binding site [nucleotide binding] 655817001321 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 655817001322 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 655817001323 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655817001324 putative active site [active] 655817001325 heme pocket [chemical binding]; other site 655817001326 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817001327 dimer interface [polypeptide binding]; other site 655817001328 phosphorylation site [posttranslational modification] 655817001329 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817001330 ATP binding site [chemical binding]; other site 655817001331 Mg2+ binding site [ion binding]; other site 655817001332 G-X-G motif; other site 655817001333 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 655817001334 putative proline-specific permease; Provisional; Region: proY; PRK10580 655817001335 Spore germination protein; Region: Spore_permease; cl17796 655817001336 maltodextrin glucosidase; Provisional; Region: PRK10785 655817001337 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 655817001338 homodimer interface [polypeptide binding]; other site 655817001339 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 655817001340 active site 655817001341 homodimer interface [polypeptide binding]; other site 655817001342 catalytic site [active] 655817001343 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 655817001344 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 655817001345 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 655817001346 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 655817001347 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 655817001348 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 655817001349 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 655817001350 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 655817001351 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 655817001352 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 655817001353 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 655817001354 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 655817001355 Protein export membrane protein; Region: SecD_SecF; pfam02355 655817001356 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 655817001357 active site 655817001358 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 655817001359 hypothetical protein; Provisional; Region: PRK11530 655817001360 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 655817001361 ATP cone domain; Region: ATP-cone; pfam03477 655817001362 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 655817001363 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 655817001364 catalytic motif [active] 655817001365 Zn binding site [ion binding]; other site 655817001366 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 655817001367 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 655817001368 homopentamer interface [polypeptide binding]; other site 655817001369 active site 655817001370 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 655817001371 putative RNA binding site [nucleotide binding]; other site 655817001372 thiamine monophosphate kinase; Provisional; Region: PRK05731 655817001373 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 655817001374 ATP binding site [chemical binding]; other site 655817001375 dimerization interface [polypeptide binding]; other site 655817001376 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 655817001377 tetramer interfaces [polypeptide binding]; other site 655817001378 binuclear metal-binding site [ion binding]; other site 655817001379 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655817001380 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655817001381 active site 655817001382 catalytic tetrad [active] 655817001383 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 655817001384 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 655817001385 TPP-binding site; other site 655817001386 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 655817001387 PYR/PP interface [polypeptide binding]; other site 655817001388 dimer interface [polypeptide binding]; other site 655817001389 TPP binding site [chemical binding]; other site 655817001390 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655817001391 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 655817001392 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 655817001393 substrate binding pocket [chemical binding]; other site 655817001394 chain length determination region; other site 655817001395 substrate-Mg2+ binding site; other site 655817001396 catalytic residues [active] 655817001397 aspartate-rich region 1; other site 655817001398 active site lid residues [active] 655817001399 aspartate-rich region 2; other site 655817001400 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 655817001401 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 655817001402 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 655817001403 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 655817001404 Ligand Binding Site [chemical binding]; other site 655817001405 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 655817001406 active site residue [active] 655817001407 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 655817001408 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 655817001409 conserved cys residue [active] 655817001410 potential frameshift: common BLAST hit: gi|218688288|ref|YP_002396500.1| 2-dehydropantoate 2-reductase 655817001411 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 655817001412 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 655817001413 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 655817001414 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 655817001415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 655817001416 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 655817001417 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817001418 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655817001419 putative substrate translocation pore; other site 655817001420 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 655817001421 UbiA prenyltransferase family; Region: UbiA; pfam01040 655817001422 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 655817001423 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 655817001424 Subunit I/III interface [polypeptide binding]; other site 655817001425 Subunit III/IV interface [polypeptide binding]; other site 655817001426 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 655817001427 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 655817001428 D-pathway; other site 655817001429 Putative ubiquinol binding site [chemical binding]; other site 655817001430 Low-spin heme (heme b) binding site [chemical binding]; other site 655817001431 Putative water exit pathway; other site 655817001432 Binuclear center (heme o3/CuB) [ion binding]; other site 655817001433 K-pathway; other site 655817001434 Putative proton exit pathway; other site 655817001435 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 655817001436 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 655817001437 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 655817001438 muropeptide transporter; Reviewed; Region: ampG; PRK11902 655817001439 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817001440 putative substrate translocation pore; other site 655817001441 hypothetical protein; Provisional; Region: PRK11627 655817001442 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 655817001443 transcriptional regulator BolA; Provisional; Region: PRK11628 655817001444 trigger factor; Provisional; Region: tig; PRK01490 655817001445 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 655817001446 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 655817001447 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 655817001448 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 655817001449 oligomer interface [polypeptide binding]; other site 655817001450 active site residues [active] 655817001451 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 655817001452 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 655817001453 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817001454 Walker A motif; other site 655817001455 ATP binding site [chemical binding]; other site 655817001456 Walker B motif; other site 655817001457 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 655817001458 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 655817001459 Found in ATP-dependent protease La (LON); Region: LON; smart00464 655817001460 Found in ATP-dependent protease La (LON); Region: LON; smart00464 655817001461 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817001462 Walker A motif; other site 655817001463 ATP binding site [chemical binding]; other site 655817001464 Walker B motif; other site 655817001465 arginine finger; other site 655817001466 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 655817001467 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 655817001468 IHF dimer interface [polypeptide binding]; other site 655817001469 IHF - DNA interface [nucleotide binding]; other site 655817001470 periplasmic folding chaperone; Provisional; Region: PRK10788 655817001471 SurA N-terminal domain; Region: SurA_N_3; cl07813 655817001472 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 655817001473 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 655817001474 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 655817001475 active site 655817001476 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 655817001477 Ligand Binding Site [chemical binding]; other site 655817001478 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 655817001479 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 655817001480 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 655817001481 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 655817001482 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817001483 active site 655817001484 motif I; other site 655817001485 motif II; other site 655817001486 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 655817001487 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655817001488 putative DNA binding site [nucleotide binding]; other site 655817001489 putative Zn2+ binding site [ion binding]; other site 655817001490 AsnC family; Region: AsnC_trans_reg; pfam01037 655817001491 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655817001492 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 655817001493 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817001494 Walker A/P-loop; other site 655817001495 ATP binding site [chemical binding]; other site 655817001496 Q-loop/lid; other site 655817001497 ABC transporter signature motif; other site 655817001498 Walker B; other site 655817001499 D-loop; other site 655817001500 H-loop/switch region; other site 655817001501 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 655817001502 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655817001503 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 655817001504 Walker A/P-loop; other site 655817001505 ATP binding site [chemical binding]; other site 655817001506 Q-loop/lid; other site 655817001507 ABC transporter signature motif; other site 655817001508 Walker B; other site 655817001509 D-loop; other site 655817001510 H-loop/switch region; other site 655817001511 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 655817001512 Nitrogen regulatory protein P-II; Region: P-II; smart00938 655817001513 ammonium transporter; Provisional; Region: PRK10666 655817001514 acyl-CoA thioesterase II; Provisional; Region: PRK10526 655817001515 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 655817001516 active site 655817001517 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 655817001518 catalytic triad [active] 655817001519 dimer interface [polypeptide binding]; other site 655817001520 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 655817001521 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 655817001522 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 655817001523 DNA binding site [nucleotide binding] 655817001524 active site 655817001525 Uncharacterized conserved protein [Function unknown]; Region: COG5507 655817001526 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 655817001527 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 655817001528 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817001529 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 655817001530 maltose O-acetyltransferase; Provisional; Region: PRK10092 655817001531 Maltose acetyltransferase; Region: Mac; pfam12464 655817001532 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 655817001533 trimer interface [polypeptide binding]; other site 655817001534 active site 655817001535 substrate binding site [chemical binding]; other site 655817001536 CoA binding site [chemical binding]; other site 655817001537 gene expression modulator; Provisional; Region: PRK10945 655817001538 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 655817001539 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 655817001540 Protein export membrane protein; Region: SecD_SecF; cl14618 655817001541 Protein export membrane protein; Region: SecD_SecF; cl14618 655817001542 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 655817001543 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817001544 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817001545 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 655817001546 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817001547 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 655817001548 hypothetical protein; Provisional; Region: PRK11281 655817001549 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 655817001550 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 655817001551 Mechanosensitive ion channel; Region: MS_channel; pfam00924 655817001552 hypothetical protein; Provisional; Region: PRK11038 655817001553 primosomal replication protein N''; Provisional; Region: PRK10093 655817001554 hypothetical protein; Provisional; Region: PRK10527 655817001555 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655817001556 active site 655817001557 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 655817001558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817001559 Walker A motif; other site 655817001560 ATP binding site [chemical binding]; other site 655817001561 Walker B motif; other site 655817001562 DNA polymerase III subunit delta'; Validated; Region: PRK08485 655817001563 arginine finger; other site 655817001564 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 655817001565 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 655817001566 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 655817001567 hypothetical protein; Validated; Region: PRK00153 655817001568 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 655817001569 RecR protein; Region: RecR; pfam02132 655817001570 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 655817001571 putative active site [active] 655817001572 putative metal-binding site [ion binding]; other site 655817001573 tetramer interface [polypeptide binding]; other site 655817001574 heat shock protein 90; Provisional; Region: PRK05218 655817001575 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817001576 ATP binding site [chemical binding]; other site 655817001577 Mg2+ binding site [ion binding]; other site 655817001578 G-X-G motif; other site 655817001579 adenylate kinase; Reviewed; Region: adk; PRK00279 655817001580 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 655817001581 AMP-binding site [chemical binding]; other site 655817001582 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 655817001583 ferrochelatase; Region: hemH; TIGR00109 655817001584 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 655817001585 C-terminal domain interface [polypeptide binding]; other site 655817001586 active site 655817001587 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 655817001588 active site 655817001589 N-terminal domain interface [polypeptide binding]; other site 655817001590 acetyl esterase; Provisional; Region: PRK10162 655817001591 inosine/guanosine kinase; Provisional; Region: PRK15074 655817001592 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655817001593 putative cation:proton antiport protein; Provisional; Region: PRK10669 655817001594 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 655817001595 TrkA-N domain; Region: TrkA_N; pfam02254 655817001596 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817001597 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655817001598 putative substrate translocation pore; other site 655817001599 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 655817001600 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 655817001601 active site 655817001602 metal binding site [ion binding]; metal-binding site 655817001603 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 655817001604 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 655817001605 putative deacylase active site [active] 655817001606 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 655817001607 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 655817001608 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 655817001609 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655817001610 non-specific DNA binding site [nucleotide binding]; other site 655817001611 salt bridge; other site 655817001612 sequence-specific DNA binding site [nucleotide binding]; other site 655817001613 copper exporting ATPase; Provisional; Region: copA; PRK10671 655817001614 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 655817001615 metal-binding site [ion binding] 655817001616 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 655817001617 metal-binding site [ion binding] 655817001618 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 655817001619 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817001620 motif II; other site 655817001621 glutaminase; Reviewed; Region: PRK12356 655817001622 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 655817001623 amino acid transporter; Region: 2A0306; TIGR00909 655817001624 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 655817001625 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 655817001626 DNA binding residues [nucleotide binding] 655817001627 dimer interface [polypeptide binding]; other site 655817001628 copper binding site [ion binding]; other site 655817001629 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 655817001630 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 655817001631 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 655817001632 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 655817001633 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817001634 Walker A/P-loop; other site 655817001635 ATP binding site [chemical binding]; other site 655817001636 Q-loop/lid; other site 655817001637 ABC transporter signature motif; other site 655817001638 Walker B; other site 655817001639 D-loop; other site 655817001640 H-loop/switch region; other site 655817001641 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 655817001642 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 655817001643 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 655817001644 oxidoreductase; Provisional; Region: PRK08017 655817001645 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 655817001646 NADP binding site [chemical binding]; other site 655817001647 active site 655817001648 steroid binding site; other site 655817001649 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 655817001650 active site 655817001651 catalytic triad [active] 655817001652 oxyanion hole [active] 655817001653 switch loop; other site 655817001654 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 655817001655 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 655817001656 Walker A/P-loop; other site 655817001657 ATP binding site [chemical binding]; other site 655817001658 Q-loop/lid; other site 655817001659 ABC transporter signature motif; other site 655817001660 Walker B; other site 655817001661 D-loop; other site 655817001662 H-loop/switch region; other site 655817001663 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 655817001664 FtsX-like permease family; Region: FtsX; pfam02687 655817001665 FtsX-like permease family; Region: FtsX; pfam02687 655817001666 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 655817001667 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 655817001668 active site residue [active] 655817001669 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 655817001670 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817001671 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655817001672 dimerization interface [polypeptide binding]; other site 655817001673 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 655817001674 ureidoglycolate hydrolase; Provisional; Region: PRK03606 655817001675 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 655817001676 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 655817001677 Bacterial transcriptional regulator; Region: IclR; pfam01614 655817001678 glyoxylate carboligase; Provisional; Region: PRK11269 655817001679 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 655817001680 PYR/PP interface [polypeptide binding]; other site 655817001681 dimer interface [polypeptide binding]; other site 655817001682 TPP binding site [chemical binding]; other site 655817001683 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 655817001684 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 655817001685 TPP-binding site [chemical binding]; other site 655817001686 hydroxypyruvate isomerase; Provisional; Region: PRK09997 655817001687 tartronate semialdehyde reductase; Provisional; Region: PRK15059 655817001688 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 655817001689 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 655817001690 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 655817001691 Na binding site [ion binding]; other site 655817001692 substrate binding site [chemical binding]; other site 655817001693 allantoinase; Provisional; Region: PRK08044 655817001694 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 655817001695 active site 655817001696 putative uracil/xanthine transporter; Provisional; Region: PRK11412 655817001697 glycerate kinase II; Provisional; Region: PRK09932 655817001698 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 655817001699 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 655817001700 Cupin domain; Region: Cupin_2; cl17218 655817001701 allantoate amidohydrolase; Region: AllC; TIGR03176 655817001702 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 655817001703 active site 655817001704 metal binding site [ion binding]; metal-binding site 655817001705 dimer interface [polypeptide binding]; other site 655817001706 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 655817001707 membrane protein FdrA; Validated; Region: PRK06091 655817001708 CoA binding domain; Region: CoA_binding; pfam02629 655817001709 CoA-ligase; Region: Ligase_CoA; pfam00549 655817001710 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 655817001711 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 655817001712 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 655817001713 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 655817001714 putative substrate binding site [chemical binding]; other site 655817001715 nucleotide binding site [chemical binding]; other site 655817001716 nucleotide binding site [chemical binding]; other site 655817001717 homodimer interface [polypeptide binding]; other site 655817001718 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 655817001719 ATP-grasp domain; Region: ATP-grasp; pfam02222 655817001720 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 655817001721 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 655817001722 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 655817001723 putative active site [active] 655817001724 putative metal binding site [ion binding]; other site 655817001725 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 655817001726 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 655817001727 active site 655817001728 HIGH motif; other site 655817001729 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 655817001730 KMSKS motif; other site 655817001731 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 655817001732 tRNA binding surface [nucleotide binding]; other site 655817001733 anticodon binding site; other site 655817001734 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 655817001735 ribosome-associated protein; Provisional; Region: PRK11507 655817001736 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 655817001737 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 655817001738 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 655817001739 homodimer interface [polypeptide binding]; other site 655817001740 NADP binding site [chemical binding]; other site 655817001741 substrate binding site [chemical binding]; other site 655817001742 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 655817001743 DNA binding site [nucleotide binding] 655817001744 active site 655817001745 Int/Topo IB signature motif; other site 655817001746 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 655817001747 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 655817001748 Methyltransferase domain; Region: Methyltransf_12; pfam08242 655817001749 S-adenosylmethionine binding site [chemical binding]; other site 655817001750 outer membrane protease; Reviewed; Region: PRK10993 655817001751 hypothetical protein; Provisional; Region: PRK09936 655817001752 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 655817001753 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655817001754 TPR motif; other site 655817001755 binding surface 655817001756 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 655817001757 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 655817001758 active site 655817001759 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 655817001760 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 655817001761 sensor kinase CusS; Provisional; Region: PRK09835 655817001762 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655817001763 dimerization interface [polypeptide binding]; other site 655817001764 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817001765 dimer interface [polypeptide binding]; other site 655817001766 phosphorylation site [posttranslational modification] 655817001767 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817001768 ATP binding site [chemical binding]; other site 655817001769 Mg2+ binding site [ion binding]; other site 655817001770 G-X-G motif; other site 655817001771 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 655817001772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817001773 active site 655817001774 phosphorylation site [posttranslational modification] 655817001775 intermolecular recognition site; other site 655817001776 dimerization interface [polypeptide binding]; other site 655817001777 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817001778 DNA binding site [nucleotide binding] 655817001779 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 655817001780 periplasmic copper-binding protein; Provisional; Region: PRK09838 655817001781 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 655817001782 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817001783 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 655817001784 phenylalanine transporter; Provisional; Region: PRK10249 655817001785 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 655817001786 Mechanosensitive ion channel; Region: MS_channel; pfam00924 655817001787 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 655817001788 dimer interface [polypeptide binding]; other site 655817001789 FMN binding site [chemical binding]; other site 655817001790 hypothetical protein; Provisional; Region: PRK10250 655817001791 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 655817001792 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 655817001793 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 655817001794 Hok/gef family; Region: HOK_GEF; pfam01848 655817001795 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 655817001796 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 655817001797 outer membrane receptor FepA; Provisional; Region: PRK13524 655817001798 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817001799 N-terminal plug; other site 655817001800 ligand-binding site [chemical binding]; other site 655817001801 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 655817001802 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 655817001803 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 655817001804 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 655817001805 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 655817001806 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655817001807 acyl-activating enzyme (AAE) consensus motif; other site 655817001808 AMP binding site [chemical binding]; other site 655817001809 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817001810 LPS O-antigen length regulator; Provisional; Region: PRK10381 655817001811 Chain length determinant protein; Region: Wzz; pfam02706 655817001812 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 655817001813 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655817001814 Walker A/P-loop; other site 655817001815 ATP binding site [chemical binding]; other site 655817001816 Q-loop/lid; other site 655817001817 ABC transporter signature motif; other site 655817001818 Walker B; other site 655817001819 D-loop; other site 655817001820 H-loop/switch region; other site 655817001821 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 655817001822 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817001823 ABC-ATPase subunit interface; other site 655817001824 dimer interface [polypeptide binding]; other site 655817001825 putative PBP binding regions; other site 655817001826 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 655817001827 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817001828 ABC-ATPase subunit interface; other site 655817001829 dimer interface [polypeptide binding]; other site 655817001830 putative PBP binding regions; other site 655817001831 enterobactin exporter EntS; Provisional; Region: PRK10489 655817001832 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817001833 putative substrate translocation pore; other site 655817001834 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 655817001835 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 655817001836 siderophore binding site; other site 655817001837 isochorismate synthase EntC; Provisional; Region: PRK15016 655817001838 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 655817001839 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 655817001840 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 655817001841 acyl-activating enzyme (AAE) consensus motif; other site 655817001842 active site 655817001843 AMP binding site [chemical binding]; other site 655817001844 substrate binding site [chemical binding]; other site 655817001845 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 655817001846 hydrophobic substrate binding pocket; other site 655817001847 Isochorismatase family; Region: Isochorismatase; pfam00857 655817001848 active site 655817001849 conserved cis-peptide bond; other site 655817001850 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 655817001851 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 655817001852 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 655817001853 putative NAD(P) binding site [chemical binding]; other site 655817001854 active site 655817001855 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 655817001856 CoenzymeA binding site [chemical binding]; other site 655817001857 subunit interaction site [polypeptide binding]; other site 655817001858 PHB binding site; other site 655817001859 carbon starvation protein A; Provisional; Region: PRK15015 655817001860 Carbon starvation protein CstA; Region: CstA; pfam02554 655817001861 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 655817001862 Uncharacterized small protein [Function unknown]; Region: COG2879 655817001863 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 655817001864 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 655817001865 putative active site [active] 655817001866 metal binding site [ion binding]; metal-binding site 655817001867 methionine aminotransferase; Validated; Region: PRK09082 655817001868 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655817001869 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817001870 homodimer interface [polypeptide binding]; other site 655817001871 catalytic residue [active] 655817001872 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 655817001873 ParB-like nuclease domain; Region: ParBc; pfam02195 655817001874 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 655817001875 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 655817001876 Active Sites [active] 655817001877 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 655817001878 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 655817001879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817001880 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655817001881 dimerization interface [polypeptide binding]; other site 655817001882 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 655817001883 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 655817001884 dimerization domain [polypeptide binding]; other site 655817001885 dimer interface [polypeptide binding]; other site 655817001886 catalytic residues [active] 655817001887 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 655817001888 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 655817001889 dimer interface [polypeptide binding]; other site 655817001890 decamer (pentamer of dimers) interface [polypeptide binding]; other site 655817001891 catalytic triad [active] 655817001892 peroxidatic and resolving cysteines [active] 655817001893 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 655817001894 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 655817001895 catalytic residue [active] 655817001896 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 655817001897 catalytic residues [active] 655817001898 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655817001899 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817001900 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 655817001901 Ligand Binding Site [chemical binding]; other site 655817001902 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 655817001903 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 655817001904 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 655817001905 B1 nucleotide binding pocket [chemical binding]; other site 655817001906 B2 nucleotide binding pocket [chemical binding]; other site 655817001907 CAS motifs; other site 655817001908 active site 655817001909 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 655817001910 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 655817001911 transmembrane helices; other site 655817001912 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 655817001913 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 655817001914 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 655817001915 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 655817001916 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 655817001917 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 655817001918 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 655817001919 putative active site [active] 655817001920 (T/H)XGH motif; other site 655817001921 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 655817001922 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655817001923 putative active site [active] 655817001924 heme pocket [chemical binding]; other site 655817001925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817001926 ATP binding site [chemical binding]; other site 655817001927 Mg2+ binding site [ion binding]; other site 655817001928 G-X-G motif; other site 655817001929 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 655817001930 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817001931 active site 655817001932 phosphorylation site [posttranslational modification] 655817001933 intermolecular recognition site; other site 655817001934 dimerization interface [polypeptide binding]; other site 655817001935 Transcriptional regulator; Region: CitT; pfam12431 655817001936 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 655817001937 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 655817001938 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 655817001939 DNA-binding site [nucleotide binding]; DNA binding site 655817001940 RNA-binding motif; other site 655817001941 chromosome condensation membrane protein; Provisional; Region: PRK14196 655817001942 Predicted amidohydrolase [General function prediction only]; Region: COG0388 655817001943 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 655817001944 putative active site [active] 655817001945 catalytic triad [active] 655817001946 putative dimer interface [polypeptide binding]; other site 655817001947 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 655817001948 lipoyl synthase; Provisional; Region: PRK05481 655817001949 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817001950 FeS/SAM binding site; other site 655817001951 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 655817001952 lipoate-protein ligase B; Provisional; Region: PRK14342 655817001953 hypothetical protein; Provisional; Region: PRK04998 655817001954 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 655817001955 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 655817001956 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 655817001957 rare lipoprotein A; Provisional; Region: PRK10672 655817001958 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 655817001959 Sporulation related domain; Region: SPOR; pfam05036 655817001960 cell wall shape-determining protein; Provisional; Region: PRK10794 655817001961 penicillin-binding protein 2; Provisional; Region: PRK10795 655817001962 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 655817001963 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 655817001964 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 655817001965 ribosome-associated protein; Provisional; Region: PRK11538 655817001966 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 655817001967 catalytic core [active] 655817001968 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 655817001969 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 655817001970 active site 655817001971 (T/H)XGH motif; other site 655817001972 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 655817001973 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 655817001974 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 655817001975 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 655817001976 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 655817001977 HIGH motif; other site 655817001978 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 655817001979 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 655817001980 active site 655817001981 KMSKS motif; other site 655817001982 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 655817001983 tRNA binding surface [nucleotide binding]; other site 655817001984 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 655817001985 hypothetical protein; Provisional; Region: PRK11032 655817001986 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 655817001987 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 655817001988 active site 655817001989 tetramer interface [polypeptide binding]; other site 655817001990 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 655817001991 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 655817001992 Walker A/P-loop; other site 655817001993 ATP binding site [chemical binding]; other site 655817001994 Q-loop/lid; other site 655817001995 ABC transporter signature motif; other site 655817001996 Walker B; other site 655817001997 D-loop; other site 655817001998 H-loop/switch region; other site 655817001999 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 655817002000 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817002001 dimer interface [polypeptide binding]; other site 655817002002 conserved gate region; other site 655817002003 putative PBP binding loops; other site 655817002004 ABC-ATPase subunit interface; other site 655817002005 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 655817002006 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817002007 dimer interface [polypeptide binding]; other site 655817002008 conserved gate region; other site 655817002009 putative PBP binding loops; other site 655817002010 ABC-ATPase subunit interface; other site 655817002011 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 655817002012 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817002013 substrate binding pocket [chemical binding]; other site 655817002014 membrane-bound complex binding site; other site 655817002015 hinge residues; other site 655817002016 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 655817002017 WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from...; Region: WD40; cl02567 655817002018 Uncharacterized conserved protein [Function unknown]; Region: COG3391 655817002019 structural tetrad; other site 655817002020 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 655817002021 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 655817002022 putative active site [active] 655817002023 catalytic triad [active] 655817002024 putative dimer interface [polypeptide binding]; other site 655817002025 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 655817002026 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 655817002027 Transporter associated domain; Region: CorC_HlyC; smart01091 655817002028 metal-binding heat shock protein; Provisional; Region: PRK00016 655817002029 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 655817002030 PhoH-like protein; Region: PhoH; pfam02562 655817002031 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 655817002032 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 655817002033 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817002034 FeS/SAM binding site; other site 655817002035 TRAM domain; Region: TRAM; pfam01938 655817002036 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 655817002037 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 655817002038 asparagine synthetase B; Provisional; Region: asnB; PRK09431 655817002039 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 655817002040 active site 655817002041 dimer interface [polypeptide binding]; other site 655817002042 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 655817002043 Ligand Binding Site [chemical binding]; other site 655817002044 Molecular Tunnel; other site 655817002045 UMP phosphatase; Provisional; Region: PRK10444 655817002046 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817002047 active site 655817002048 motif I; other site 655817002049 motif II; other site 655817002050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817002051 MarR family; Region: MarR; pfam01047 655817002052 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 655817002053 ROK family; Region: ROK; pfam00480 655817002054 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 655817002055 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 655817002056 active site 655817002057 dimer interface [polypeptide binding]; other site 655817002058 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 655817002059 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 655817002060 active site 655817002061 trimer interface [polypeptide binding]; other site 655817002062 allosteric site; other site 655817002063 active site lid [active] 655817002064 hexamer (dimer of trimers) interface [polypeptide binding]; other site 655817002065 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 655817002066 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655817002067 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655817002068 active site turn [active] 655817002069 phosphorylation site [posttranslational modification] 655817002070 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 655817002071 HPr interaction site; other site 655817002072 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655817002073 active site 655817002074 phosphorylation site [posttranslational modification] 655817002075 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 655817002076 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 655817002077 transmembrane helices; other site 655817002078 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 655817002079 BNR repeat-like domain; Region: BNR_2; pfam13088 655817002080 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 655817002081 dihydrodipicolinate synthase; Region: dapA; TIGR00674 655817002082 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 655817002083 inhibitor site; inhibition site 655817002084 active site 655817002085 dimer interface [polypeptide binding]; other site 655817002086 catalytic residue [active] 655817002087 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 655817002088 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 655817002089 putative active site [active] 655817002090 metal binding site [ion binding]; metal-binding site 655817002091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 655817002092 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 655817002093 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 655817002094 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655817002095 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 655817002096 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817002097 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 655817002098 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 655817002099 active site 655817002100 HIGH motif; other site 655817002101 nucleotide binding site [chemical binding]; other site 655817002102 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 655817002103 KMSKS motif; other site 655817002104 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 655817002105 outer membrane porin, OprD family; Region: OprD; pfam03573 655817002106 YbfN-like lipoprotein; Region: YbfN; pfam13982 655817002107 ferric uptake regulator; Provisional; Region: fur; PRK09462 655817002108 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 655817002109 metal binding site 2 [ion binding]; metal-binding site 655817002110 putative DNA binding helix; other site 655817002111 metal binding site 1 [ion binding]; metal-binding site 655817002112 dimer interface [polypeptide binding]; other site 655817002113 structural Zn2+ binding site [ion binding]; other site 655817002114 flavodoxin FldA; Validated; Region: PRK09267 655817002115 LexA regulated protein; Provisional; Region: PRK11675 655817002116 acyl-CoA esterase; Provisional; Region: PRK10673 655817002117 PGAP1-like protein; Region: PGAP1; pfam07819 655817002118 replication initiation regulator SeqA; Provisional; Region: PRK11187 655817002119 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 655817002120 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 655817002121 active site 655817002122 substrate binding site [chemical binding]; other site 655817002123 metal binding site [ion binding]; metal-binding site 655817002124 putrescine transporter; Provisional; Region: potE; PRK10655 655817002125 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 655817002126 ornithine decarboxylase; Provisional; Region: PRK13578 655817002127 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 655817002128 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 655817002129 homodimer interface [polypeptide binding]; other site 655817002130 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817002131 catalytic residue [active] 655817002132 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 655817002133 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 655817002134 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817002135 active site 655817002136 phosphorylation site [posttranslational modification] 655817002137 intermolecular recognition site; other site 655817002138 dimerization interface [polypeptide binding]; other site 655817002139 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817002140 DNA binding site [nucleotide binding] 655817002141 sensor protein KdpD; Provisional; Region: PRK10490 655817002142 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 655817002143 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 655817002144 Ligand Binding Site [chemical binding]; other site 655817002145 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 655817002146 GAF domain; Region: GAF_3; pfam13492 655817002147 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817002148 dimer interface [polypeptide binding]; other site 655817002149 phosphorylation site [posttranslational modification] 655817002150 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817002151 ATP binding site [chemical binding]; other site 655817002152 Mg2+ binding site [ion binding]; other site 655817002153 G-X-G motif; other site 655817002154 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 655817002155 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 655817002156 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 655817002157 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 655817002158 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 655817002159 hypothetical protein; Provisional; Region: PRK10167 655817002160 Uncharacterized conserved protein [Function unknown]; Region: COG3272 655817002161 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 655817002162 DNA photolyase; Region: DNA_photolyase; pfam00875 655817002163 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 655817002164 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817002165 putative substrate translocation pore; other site 655817002166 POT family; Region: PTR2; pfam00854 655817002167 Uncharacterized conserved protein [Function unknown]; Region: COG0327 655817002168 metal-binding protein; Provisional; Region: PRK10799 655817002169 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 655817002170 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 655817002171 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 655817002172 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 655817002173 endonuclease VIII; Provisional; Region: PRK10445 655817002174 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 655817002175 DNA binding site [nucleotide binding] 655817002176 catalytic residue [active] 655817002177 putative catalytic residues [active] 655817002178 H2TH interface [polypeptide binding]; other site 655817002179 intercalation triad [nucleotide binding]; other site 655817002180 substrate specificity determining residue; other site 655817002181 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 655817002182 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 655817002183 Putative ammonia monooxygenase; Region: AmoA; pfam05145 655817002184 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 655817002185 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 655817002186 potential frameshift: common BLAST hit: gi|238899981|ref|YP_002925777.1| putative fimbrial-like adhesin protein 655817002187 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 655817002188 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 655817002189 dimer interface [polypeptide binding]; other site 655817002190 active site 655817002191 citrylCoA binding site [chemical binding]; other site 655817002192 NADH binding [chemical binding]; other site 655817002193 cationic pore residues; other site 655817002194 oxalacetate/citrate binding site [chemical binding]; other site 655817002195 coenzyme A binding site [chemical binding]; other site 655817002196 catalytic triad [active] 655817002197 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 655817002198 Iron-sulfur protein interface; other site 655817002199 proximal quinone binding site [chemical binding]; other site 655817002200 SdhD (CybS) interface [polypeptide binding]; other site 655817002201 proximal heme binding site [chemical binding]; other site 655817002202 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 655817002203 SdhC subunit interface [polypeptide binding]; other site 655817002204 proximal heme binding site [chemical binding]; other site 655817002205 cardiolipin binding site; other site 655817002206 Iron-sulfur protein interface; other site 655817002207 proximal quinone binding site [chemical binding]; other site 655817002208 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 655817002209 L-aspartate oxidase; Provisional; Region: PRK06175 655817002210 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 655817002211 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 655817002212 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 655817002213 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 655817002214 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 655817002215 TPP-binding site [chemical binding]; other site 655817002216 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 655817002217 dimer interface [polypeptide binding]; other site 655817002218 PYR/PP interface [polypeptide binding]; other site 655817002219 TPP binding site [chemical binding]; other site 655817002220 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 655817002221 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 655817002222 E3 interaction surface; other site 655817002223 lipoyl attachment site [posttranslational modification]; other site 655817002224 e3 binding domain; Region: E3_binding; pfam02817 655817002225 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 655817002226 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 655817002227 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 655817002228 CoA-ligase; Region: Ligase_CoA; pfam00549 655817002229 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 655817002230 CoA binding domain; Region: CoA_binding; smart00881 655817002231 CoA-ligase; Region: Ligase_CoA; pfam00549 655817002232 TPR repeat; Region: TPR_11; pfam13414 655817002233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655817002234 binding surface 655817002235 TPR motif; other site 655817002236 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 655817002237 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 655817002238 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 655817002239 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 655817002240 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 655817002241 hypothetical protein; Provisional; Region: PRK10588 655817002242 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 655817002243 active site 655817002244 colicin uptake protein TolQ; Provisional; Region: PRK10801 655817002245 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 655817002246 colicin uptake protein TolR; Provisional; Region: PRK11024 655817002247 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 655817002248 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 655817002249 TolA C-terminal; Region: TolA; pfam06519 655817002250 translocation protein TolB; Provisional; Region: tolB; PRK03629 655817002251 TolB amino-terminal domain; Region: TolB_N; pfam04052 655817002252 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 655817002253 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 655817002254 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 655817002255 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 655817002256 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 655817002257 ligand binding site [chemical binding]; other site 655817002258 tol-pal system protein YbgF; Provisional; Region: PRK10803 655817002259 Tetratricopeptide repeat; Region: TPR_6; pfam13174 655817002260 Tetratricopeptide repeat; Region: TPR_6; pfam13174 655817002261 quinolinate synthetase; Provisional; Region: PRK09375 655817002262 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 655817002263 Cation efflux family; Region: Cation_efflux; cl00316 655817002264 YbgS-like protein; Region: YbgS; pfam13985 655817002265 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 655817002266 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 655817002267 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 655817002268 catalytic core [active] 655817002269 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 655817002270 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 655817002271 active site 655817002272 catalytic residues [active] 655817002273 galactokinase; Provisional; Region: PRK05101 655817002274 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 655817002275 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 655817002276 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 655817002277 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 655817002278 dimer interface [polypeptide binding]; other site 655817002279 active site 655817002280 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 655817002281 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 655817002282 NAD binding site [chemical binding]; other site 655817002283 homodimer interface [polypeptide binding]; other site 655817002284 active site 655817002285 substrate binding site [chemical binding]; other site 655817002286 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 655817002287 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 655817002288 Walker A/P-loop; other site 655817002289 ATP binding site [chemical binding]; other site 655817002290 Q-loop/lid; other site 655817002291 ABC transporter signature motif; other site 655817002292 Walker B; other site 655817002293 D-loop; other site 655817002294 H-loop/switch region; other site 655817002295 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817002296 Walker A/P-loop; other site 655817002297 ATP binding site [chemical binding]; other site 655817002298 Q-loop/lid; other site 655817002299 ABC transporter signature motif; other site 655817002300 Walker B; other site 655817002301 D-loop; other site 655817002302 H-loop/switch region; other site 655817002303 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 655817002304 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 655817002305 molybdenum-pterin binding domain; Region: Mop; TIGR00638 655817002306 TOBE domain; Region: TOBE; pfam03459 655817002307 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 655817002308 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817002309 substrate binding pocket [chemical binding]; other site 655817002310 membrane-bound complex binding site; other site 655817002311 hinge residues; other site 655817002312 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 655817002313 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817002314 dimer interface [polypeptide binding]; other site 655817002315 conserved gate region; other site 655817002316 putative PBP binding loops; other site 655817002317 ABC-ATPase subunit interface; other site 655817002318 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 655817002319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817002320 Walker A/P-loop; other site 655817002321 ATP binding site [chemical binding]; other site 655817002322 Q-loop/lid; other site 655817002323 ABC transporter signature motif; other site 655817002324 Walker B; other site 655817002325 D-loop; other site 655817002326 H-loop/switch region; other site 655817002327 molybdenum-pterin binding domain; Region: Mop; TIGR00638 655817002328 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 655817002329 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817002330 motif II; other site 655817002331 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817002332 6-phosphogluconolactonase; Provisional; Region: PRK11028 655817002333 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655817002334 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817002335 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 655817002336 putative dimerization interface [polypeptide binding]; other site 655817002337 PrpF protein; Region: PrpF; pfam04303 655817002338 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 655817002339 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 655817002340 transmembrane helices; other site 655817002341 putative hydratase; Provisional; Region: PRK11413 655817002342 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 655817002343 substrate binding site [chemical binding]; other site 655817002344 ligand binding site [chemical binding]; other site 655817002345 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 655817002346 substrate binding site [chemical binding]; other site 655817002347 acyl-CoA thioesterase; Provisional; Region: PRK10531 655817002348 putative pectinesterase; Region: PLN02432; cl01911 655817002349 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 655817002350 substrate binding site [chemical binding]; other site 655817002351 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 655817002352 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 655817002353 Probable transposase; Region: OrfB_IS605; pfam01385 655817002354 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 655817002355 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 655817002356 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655817002357 inhibitor-cofactor binding pocket; inhibition site 655817002358 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817002359 catalytic residue [active] 655817002360 biotin synthase; Provisional; Region: PRK15108 655817002361 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817002362 FeS/SAM binding site; other site 655817002363 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 655817002364 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 655817002365 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 655817002366 substrate-cofactor binding pocket; other site 655817002367 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817002368 catalytic residue [active] 655817002369 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 655817002370 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817002371 S-adenosylmethionine binding site [chemical binding]; other site 655817002372 AAA domain; Region: AAA_26; pfam13500 655817002373 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 655817002374 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 655817002375 ADP binding site [chemical binding]; other site 655817002376 excinuclease ABC subunit B; Provisional; Region: PRK05298 655817002377 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655817002378 ATP binding site [chemical binding]; other site 655817002379 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817002380 nucleotide binding region [chemical binding]; other site 655817002381 ATP-binding site [chemical binding]; other site 655817002382 Ultra-violet resistance protein B; Region: UvrB; pfam12344 655817002383 UvrB/uvrC motif; Region: UVR; pfam02151 655817002384 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 655817002385 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 655817002386 putative substrate binding pocket [chemical binding]; other site 655817002387 dimer interface [polypeptide binding]; other site 655817002388 phosphate binding site [ion binding]; other site 655817002389 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 655817002390 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817002391 FeS/SAM binding site; other site 655817002392 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 655817002393 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 655817002394 MPT binding site; other site 655817002395 trimer interface [polypeptide binding]; other site 655817002396 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 655817002397 trimer interface [polypeptide binding]; other site 655817002398 dimer interface [polypeptide binding]; other site 655817002399 putative active site [active] 655817002400 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 655817002401 MoaE interaction surface [polypeptide binding]; other site 655817002402 MoeB interaction surface [polypeptide binding]; other site 655817002403 thiocarboxylated glycine; other site 655817002404 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 655817002405 MoaE homodimer interface [polypeptide binding]; other site 655817002406 MoaD interaction [polypeptide binding]; other site 655817002407 active site residues [active] 655817002408 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 655817002409 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 655817002410 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 655817002411 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 655817002412 Predicted integral membrane protein [Function unknown]; Region: COG0392 655817002413 cardiolipin synthase 2; Provisional; Region: PRK11263 655817002414 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 655817002415 putative active site [active] 655817002416 catalytic site [active] 655817002417 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 655817002418 putative active site [active] 655817002419 catalytic site [active] 655817002420 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 655817002421 putative catalytic site [active] 655817002422 putative metal binding site [ion binding]; other site 655817002423 putative phosphate binding site [ion binding]; other site 655817002424 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 655817002425 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 655817002426 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 655817002427 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 655817002428 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 655817002429 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 655817002430 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 655817002431 Walker A/P-loop; other site 655817002432 ATP binding site [chemical binding]; other site 655817002433 Q-loop/lid; other site 655817002434 ABC transporter signature motif; other site 655817002435 Walker B; other site 655817002436 D-loop; other site 655817002437 H-loop/switch region; other site 655817002438 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 655817002439 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 655817002440 Walker A/P-loop; other site 655817002441 ATP binding site [chemical binding]; other site 655817002442 Q-loop/lid; other site 655817002443 ABC transporter signature motif; other site 655817002444 Walker B; other site 655817002445 D-loop; other site 655817002446 H-loop/switch region; other site 655817002447 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 655817002448 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817002449 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817002450 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 655817002451 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817002452 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 655817002453 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 655817002454 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 655817002455 ATP binding site [chemical binding]; other site 655817002456 Mg++ binding site [ion binding]; other site 655817002457 motif III; other site 655817002458 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817002459 nucleotide binding region [chemical binding]; other site 655817002460 ATP-binding site [chemical binding]; other site 655817002461 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 655817002462 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 655817002463 DEAD_2; Region: DEAD_2; pfam06733 655817002464 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 655817002465 glycosyl transferase family protein; Provisional; Region: PRK08136 655817002466 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 655817002467 putative dehydrogenase; Provisional; Region: PRK10098 655817002468 hypothetical protein; Provisional; Region: PRK10259 655817002469 hypothetical protein; Provisional; Region: PRK11019 655817002470 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 655817002471 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 655817002472 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817002473 N-terminal plug; other site 655817002474 ligand-binding site [chemical binding]; other site 655817002475 hypothetical protein; Provisional; Region: PRK10259 655817002476 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 655817002477 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 655817002478 putative mechanosensitive channel protein; Provisional; Region: PRK11465 655817002479 Mechanosensitive ion channel; Region: MS_channel; pfam00924 655817002480 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 655817002481 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 655817002482 Walker A/P-loop; other site 655817002483 ATP binding site [chemical binding]; other site 655817002484 Q-loop/lid; other site 655817002485 ABC transporter signature motif; other site 655817002486 Walker B; other site 655817002487 D-loop; other site 655817002488 H-loop/switch region; other site 655817002489 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 655817002490 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817002491 dimer interface [polypeptide binding]; other site 655817002492 conserved gate region; other site 655817002493 putative PBP binding loops; other site 655817002494 ABC-ATPase subunit interface; other site 655817002495 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 655817002496 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817002497 substrate binding pocket [chemical binding]; other site 655817002498 membrane-bound complex binding site; other site 655817002499 hinge residues; other site 655817002500 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 655817002501 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 655817002502 dimerization interface [polypeptide binding]; other site 655817002503 DPS ferroxidase diiron center [ion binding]; other site 655817002504 ion pore; other site 655817002505 threonine and homoserine efflux system; Provisional; Region: PRK10532 655817002506 EamA-like transporter family; Region: EamA; pfam00892 655817002507 outer membrane protein X; Provisional; Region: ompX; PRK09408 655817002508 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 655817002509 Sulfatase; Region: Sulfatase; pfam00884 655817002510 manganese transport regulator MntR; Provisional; Region: PRK11050 655817002511 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 655817002512 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 655817002513 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 655817002514 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 655817002515 transmembrane helices; other site 655817002516 L,D-transpeptidase; Provisional; Region: PRK10260 655817002517 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 655817002518 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 655817002519 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817002520 Walker A/P-loop; other site 655817002521 ATP binding site [chemical binding]; other site 655817002522 Q-loop/lid; other site 655817002523 ABC transporter signature motif; other site 655817002524 Walker B; other site 655817002525 D-loop; other site 655817002526 H-loop/switch region; other site 655817002527 ABC transporter; Region: ABC_tran_2; pfam12848 655817002528 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655817002529 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 655817002530 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817002531 active site 655817002532 motif I; other site 655817002533 motif II; other site 655817002534 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817002535 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 655817002536 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 655817002537 dimer interface [polypeptide binding]; other site 655817002538 active site 655817002539 glycine loop; other site 655817002540 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 655817002541 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 655817002542 active site 655817002543 intersubunit interactions; other site 655817002544 catalytic residue [active] 655817002545 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 655817002546 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 655817002547 ATP binding site [chemical binding]; other site 655817002548 substrate interface [chemical binding]; other site 655817002549 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 655817002550 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 655817002551 dimer interface [polypeptide binding]; other site 655817002552 putative functional site; other site 655817002553 putative MPT binding site; other site 655817002554 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 655817002555 catalytic nucleophile [active] 655817002556 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 655817002557 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817002558 Walker A/P-loop; other site 655817002559 ATP binding site [chemical binding]; other site 655817002560 Q-loop/lid; other site 655817002561 ABC transporter signature motif; other site 655817002562 Walker B; other site 655817002563 D-loop; other site 655817002564 H-loop/switch region; other site 655817002565 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 655817002566 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817002567 Walker A/P-loop; other site 655817002568 ATP binding site [chemical binding]; other site 655817002569 Q-loop/lid; other site 655817002570 ABC transporter signature motif; other site 655817002571 Walker B; other site 655817002572 D-loop; other site 655817002573 H-loop/switch region; other site 655817002574 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 655817002575 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 655817002576 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 655817002577 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 655817002578 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817002579 dimer interface [polypeptide binding]; other site 655817002580 conserved gate region; other site 655817002581 putative PBP binding loops; other site 655817002582 ABC-ATPase subunit interface; other site 655817002583 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 655817002584 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 655817002585 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817002586 dimer interface [polypeptide binding]; other site 655817002587 conserved gate region; other site 655817002588 putative PBP binding loops; other site 655817002589 ABC-ATPase subunit interface; other site 655817002590 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817002591 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 655817002592 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817002593 metal binding site [ion binding]; metal-binding site 655817002594 active site 655817002595 I-site; other site 655817002596 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 655817002597 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 655817002598 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817002599 FeS/SAM binding site; other site 655817002600 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 655817002601 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 655817002602 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 655817002603 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 655817002604 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 655817002605 putative C-terminal domain interface [polypeptide binding]; other site 655817002606 putative GSH binding site (G-site) [chemical binding]; other site 655817002607 putative dimer interface [polypeptide binding]; other site 655817002608 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 655817002609 N-terminal domain interface [polypeptide binding]; other site 655817002610 dimer interface [polypeptide binding]; other site 655817002611 substrate binding pocket (H-site) [chemical binding]; other site 655817002612 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 655817002613 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 655817002614 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 655817002615 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 655817002616 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 655817002617 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817002618 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 655817002619 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 655817002620 active site 655817002621 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 655817002622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817002623 putative substrate translocation pore; other site 655817002624 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 655817002625 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817002626 active site 655817002627 motif I; other site 655817002628 motif II; other site 655817002629 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817002630 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 655817002631 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817002632 putative substrate translocation pore; other site 655817002633 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655817002634 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 655817002635 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817002636 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 655817002637 putative transporter; Provisional; Region: PRK04972 655817002638 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 655817002639 TrkA-C domain; Region: TrkA_C; pfam02080 655817002640 TrkA-C domain; Region: TrkA_C; pfam02080 655817002641 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 655817002642 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 655817002643 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 655817002644 GSH binding site [chemical binding]; other site 655817002645 catalytic residues [active] 655817002646 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 655817002647 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 655817002648 dimer interface [polypeptide binding]; other site 655817002649 FMN binding site [chemical binding]; other site 655817002650 NADPH bind site [chemical binding]; other site 655817002651 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 655817002652 RimK-like ATP-grasp domain; Region: RimK; pfam08443 655817002653 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 655817002654 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 655817002655 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 655817002656 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 655817002657 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817002658 Walker A/P-loop; other site 655817002659 ATP binding site [chemical binding]; other site 655817002660 Q-loop/lid; other site 655817002661 ABC transporter signature motif; other site 655817002662 Walker B; other site 655817002663 D-loop; other site 655817002664 H-loop/switch region; other site 655817002665 TOBE domain; Region: TOBE_2; pfam08402 655817002666 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 655817002667 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817002668 dimer interface [polypeptide binding]; other site 655817002669 conserved gate region; other site 655817002670 putative PBP binding loops; other site 655817002671 ABC-ATPase subunit interface; other site 655817002672 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 655817002673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817002674 dimer interface [polypeptide binding]; other site 655817002675 conserved gate region; other site 655817002676 putative PBP binding loops; other site 655817002677 ABC-ATPase subunit interface; other site 655817002678 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 655817002679 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 655817002680 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817002681 S-adenosylmethionine binding site [chemical binding]; other site 655817002682 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 655817002683 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817002684 substrate binding pocket [chemical binding]; other site 655817002685 membrane-bound complex binding site; other site 655817002686 hinge residues; other site 655817002687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817002688 dimer interface [polypeptide binding]; other site 655817002689 conserved gate region; other site 655817002690 putative PBP binding loops; other site 655817002691 ABC-ATPase subunit interface; other site 655817002692 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 655817002693 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817002694 dimer interface [polypeptide binding]; other site 655817002695 conserved gate region; other site 655817002696 putative PBP binding loops; other site 655817002697 ABC-ATPase subunit interface; other site 655817002698 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 655817002699 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817002700 substrate binding pocket [chemical binding]; other site 655817002701 membrane-bound complex binding site; other site 655817002702 hinge residues; other site 655817002703 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 655817002704 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817002705 Walker A/P-loop; other site 655817002706 ATP binding site [chemical binding]; other site 655817002707 Q-loop/lid; other site 655817002708 ABC transporter signature motif; other site 655817002709 Walker B; other site 655817002710 D-loop; other site 655817002711 H-loop/switch region; other site 655817002712 putative lipoprotein; Provisional; Region: PRK10533 655817002713 hypothetical protein; Provisional; Region: PRK02877 655817002714 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 655817002715 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 655817002716 amidase catalytic site [active] 655817002717 Zn binding residues [ion binding]; other site 655817002718 substrate binding site [chemical binding]; other site 655817002719 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 655817002720 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655817002721 NAD(P) binding site [chemical binding]; other site 655817002722 active site 655817002723 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 655817002724 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 655817002725 putative NAD(P) binding site [chemical binding]; other site 655817002726 putative active site [active] 655817002727 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 655817002728 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 655817002729 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 655817002730 tetramer interface [polypeptide binding]; other site 655817002731 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817002732 catalytic residue [active] 655817002733 pyruvate dehydrogenase; Provisional; Region: PRK09124 655817002734 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 655817002735 PYR/PP interface [polypeptide binding]; other site 655817002736 dimer interface [polypeptide binding]; other site 655817002737 tetramer interface [polypeptide binding]; other site 655817002738 TPP binding site [chemical binding]; other site 655817002739 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 655817002740 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 655817002741 TPP-binding site [chemical binding]; other site 655817002742 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 655817002743 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 655817002744 FAD binding pocket [chemical binding]; other site 655817002745 FAD binding motif [chemical binding]; other site 655817002746 phosphate binding motif [ion binding]; other site 655817002747 beta-alpha-beta structure motif; other site 655817002748 NAD binding pocket [chemical binding]; other site 655817002749 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 655817002750 catalytic loop [active] 655817002751 iron binding site [ion binding]; other site 655817002752 hybrid cluster protein; Provisional; Region: PRK05290 655817002753 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 655817002754 ACS interaction site; other site 655817002755 CODH interaction site; other site 655817002756 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 655817002757 hybrid metal cluster; other site 655817002758 Predicted membrane protein [Function unknown]; Region: COG2431 655817002759 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 655817002760 amphipathic channel; other site 655817002761 Asn-Pro-Ala signature motifs; other site 655817002762 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 655817002763 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 655817002764 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 655817002765 putative active site [active] 655817002766 putative metal-binding site [ion binding]; other site 655817002767 Protein of unknown function (DUF535); Region: DUF535; pfam04393 655817002768 macrolide transporter subunit MacA; Provisional; Region: PRK11578 655817002769 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817002770 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817002771 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 655817002772 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 655817002773 Walker A/P-loop; other site 655817002774 ATP binding site [chemical binding]; other site 655817002775 Q-loop/lid; other site 655817002776 ABC transporter signature motif; other site 655817002777 Walker B; other site 655817002778 D-loop; other site 655817002779 H-loop/switch region; other site 655817002780 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 655817002781 FtsX-like permease family; Region: FtsX; pfam02687 655817002782 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 655817002783 DNA-binding site [nucleotide binding]; DNA binding site 655817002784 RNA-binding motif; other site 655817002785 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 655817002786 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 655817002787 Clp amino terminal domain; Region: Clp_N; pfam02861 655817002788 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817002789 Walker A motif; other site 655817002790 ATP binding site [chemical binding]; other site 655817002791 Walker B motif; other site 655817002792 arginine finger; other site 655817002793 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817002794 Walker A motif; other site 655817002795 ATP binding site [chemical binding]; other site 655817002796 Walker B motif; other site 655817002797 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 655817002798 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 655817002799 rRNA binding site [nucleotide binding]; other site 655817002800 predicted 30S ribosome binding site; other site 655817002801 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 655817002802 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 655817002803 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655817002804 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 655817002805 Walker A/P-loop; other site 655817002806 ATP binding site [chemical binding]; other site 655817002807 Q-loop/lid; other site 655817002808 ABC transporter signature motif; other site 655817002809 Walker B; other site 655817002810 D-loop; other site 655817002811 H-loop/switch region; other site 655817002812 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 655817002813 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655817002814 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817002815 Walker A/P-loop; other site 655817002816 ATP binding site [chemical binding]; other site 655817002817 Q-loop/lid; other site 655817002818 ABC transporter signature motif; other site 655817002819 Walker B; other site 655817002820 D-loop; other site 655817002821 H-loop/switch region; other site 655817002822 thioredoxin reductase; Provisional; Region: PRK10262 655817002823 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655817002824 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817002825 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 655817002826 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655817002827 putative DNA binding site [nucleotide binding]; other site 655817002828 putative Zn2+ binding site [ion binding]; other site 655817002829 AsnC family; Region: AsnC_trans_reg; pfam01037 655817002830 DNA translocase FtsK; Provisional; Region: PRK10263 655817002831 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 655817002832 DNA translocase FtsK; Provisional; Region: PRK10263 655817002833 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 655817002834 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 655817002835 periplasmic chaperone LolA; Region: lolA; TIGR00547 655817002836 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 655817002837 recombination factor protein RarA; Reviewed; Region: PRK13342 655817002838 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817002839 Walker A motif; other site 655817002840 ATP binding site [chemical binding]; other site 655817002841 Walker B motif; other site 655817002842 arginine finger; other site 655817002843 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 655817002844 seryl-tRNA synthetase; Provisional; Region: PRK05431 655817002845 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 655817002846 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 655817002847 dimer interface [polypeptide binding]; other site 655817002848 active site 655817002849 motif 1; other site 655817002850 motif 2; other site 655817002851 motif 3; other site 655817002852 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 655817002853 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 655817002854 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 655817002855 putative [Fe4-S4] binding site [ion binding]; other site 655817002856 putative molybdopterin cofactor binding site [chemical binding]; other site 655817002857 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 655817002858 putative molybdopterin cofactor binding site; other site 655817002859 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 655817002860 4Fe-4S binding domain; Region: Fer4; pfam00037 655817002861 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 655817002862 Isochorismatase family; Region: Isochorismatase; pfam00857 655817002863 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 655817002864 catalytic triad [active] 655817002865 dimer interface [polypeptide binding]; other site 655817002866 conserved cis-peptide bond; other site 655817002867 putative MFS family transporter protein; Provisional; Region: PRK03633 655817002868 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817002869 putative substrate translocation pore; other site 655817002870 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 655817002871 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817002872 FeS/SAM binding site; other site 655817002873 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 655817002874 Pyruvate formate lyase 1; Region: PFL1; cd01678 655817002875 coenzyme A binding site [chemical binding]; other site 655817002876 active site 655817002877 catalytic residues [active] 655817002878 glycine loop; other site 655817002879 formate transporter; Provisional; Region: PRK10805 655817002880 uncharacterized domain; Region: TIGR00702 655817002881 YcaO-like family; Region: YcaO; pfam02624 655817002882 Predicted membrane protein [Function unknown]; Region: COG2323 655817002883 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 655817002884 homodimer interface [polypeptide binding]; other site 655817002885 substrate-cofactor binding pocket; other site 655817002886 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817002887 catalytic residue [active] 655817002888 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 655817002889 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 655817002890 hinge; other site 655817002891 active site 655817002892 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 655817002893 cytidylate kinase; Provisional; Region: cmk; PRK00023 655817002894 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 655817002895 CMP-binding site; other site 655817002896 The sites determining sugar specificity; other site 655817002897 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 655817002898 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 655817002899 RNA binding site [nucleotide binding]; other site 655817002900 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 655817002901 RNA binding site [nucleotide binding]; other site 655817002902 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 655817002903 RNA binding site [nucleotide binding]; other site 655817002904 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 655817002905 RNA binding site [nucleotide binding]; other site 655817002906 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 655817002907 RNA binding site [nucleotide binding]; other site 655817002908 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 655817002909 IHF dimer interface [polypeptide binding]; other site 655817002910 IHF - DNA interface [nucleotide binding]; other site 655817002911 ComEC family competence protein; Provisional; Region: PRK11539 655817002912 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 655817002913 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 655817002914 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 655817002915 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 655817002916 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655817002917 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 655817002918 Walker A/P-loop; other site 655817002919 ATP binding site [chemical binding]; other site 655817002920 Q-loop/lid; other site 655817002921 ABC transporter signature motif; other site 655817002922 Walker B; other site 655817002923 D-loop; other site 655817002924 H-loop/switch region; other site 655817002925 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 655817002926 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 655817002927 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 655817002928 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 655817002929 hypothetical protein; Provisional; Region: PRK11827 655817002930 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 655817002931 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 655817002932 Ligand binding site; other site 655817002933 oligomer interface; other site 655817002934 hypothetical protein; Provisional; Region: PRK10593 655817002935 Uncharacterized conserved protein [Function unknown]; Region: COG1434 655817002936 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 655817002937 putative active site [active] 655817002938 Methyltransferase domain; Region: Methyltransf_31; pfam13847 655817002939 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817002940 S-adenosylmethionine binding site [chemical binding]; other site 655817002941 condesin subunit F; Provisional; Region: PRK05260 655817002942 condesin subunit E; Provisional; Region: PRK05256 655817002943 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 655817002944 MukB N-terminal; Region: MukB; pfam04310 655817002945 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 655817002946 murein L,D-transpeptidase; Provisional; Region: PRK10594 655817002947 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 655817002948 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 655817002949 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 655817002950 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 655817002951 Peptidase M15; Region: Peptidase_M15_3; cl01194 655817002952 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 655817002953 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 655817002954 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655817002955 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817002956 homodimer interface [polypeptide binding]; other site 655817002957 catalytic residue [active] 655817002958 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 655817002959 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 655817002960 trimer interface [polypeptide binding]; other site 655817002961 eyelet of channel; other site 655817002962 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 655817002963 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 655817002964 putative dimer interface [polypeptide binding]; other site 655817002965 putative anticodon binding site; other site 655817002966 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 655817002967 homodimer interface [polypeptide binding]; other site 655817002968 motif 1; other site 655817002969 motif 2; other site 655817002970 active site 655817002971 motif 3; other site 655817002972 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 655817002973 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 655817002974 active site 655817002975 aminopeptidase N; Provisional; Region: pepN; PRK14015 655817002976 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 655817002977 active site 655817002978 Zn binding site [ion binding]; other site 655817002979 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 655817002980 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 655817002981 Walker A/P-loop; other site 655817002982 ATP binding site [chemical binding]; other site 655817002983 Q-loop/lid; other site 655817002984 ABC transporter signature motif; other site 655817002985 Walker B; other site 655817002986 D-loop; other site 655817002987 H-loop/switch region; other site 655817002988 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 655817002989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817002990 dimer interface [polypeptide binding]; other site 655817002991 conserved gate region; other site 655817002992 putative PBP binding loops; other site 655817002993 ABC-ATPase subunit interface; other site 655817002994 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 655817002995 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 655817002996 active site 655817002997 dimer interface [polypeptide binding]; other site 655817002998 non-prolyl cis peptide bond; other site 655817002999 insertion regions; other site 655817003000 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817003001 substrate binding pocket [chemical binding]; other site 655817003002 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 655817003003 membrane-bound complex binding site; other site 655817003004 hinge residues; other site 655817003005 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 655817003006 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 655817003007 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 655817003008 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 655817003009 quinone interaction residues [chemical binding]; other site 655817003010 active site 655817003011 catalytic residues [active] 655817003012 FMN binding site [chemical binding]; other site 655817003013 substrate binding site [chemical binding]; other site 655817003014 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 655817003015 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 655817003016 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 655817003017 MOSC domain; Region: MOSC; pfam03473 655817003018 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 655817003019 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 655817003020 catalytic loop [active] 655817003021 iron binding site [ion binding]; other site 655817003022 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 655817003023 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 655817003024 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 655817003025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817003026 S-adenosylmethionine binding site [chemical binding]; other site 655817003027 ABC transporter ATPase component; Reviewed; Region: PRK11147 655817003028 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817003029 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817003030 Walker A/P-loop; other site 655817003031 Walker A/P-loop; other site 655817003032 ATP binding site [chemical binding]; other site 655817003033 ATP binding site [chemical binding]; other site 655817003034 Q-loop/lid; other site 655817003035 Q-loop/lid; other site 655817003036 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655817003037 ABC transporter signature motif; other site 655817003038 Walker B; other site 655817003039 D-loop; other site 655817003040 ABC transporter; Region: ABC_tran_2; pfam12848 655817003041 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655817003042 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 655817003043 Paraquat-inducible protein A; Region: PqiA; pfam04403 655817003044 Paraquat-inducible protein A; Region: PqiA; pfam04403 655817003045 paraquat-inducible protein B; Provisional; Region: PRK10807 655817003046 mce related protein; Region: MCE; pfam02470 655817003047 mce related protein; Region: MCE; pfam02470 655817003048 mce related protein; Region: MCE; pfam02470 655817003049 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 655817003050 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 655817003051 Protein of unknown function (DUF330); Region: DUF330; pfam03886 655817003052 ribosome modulation factor; Provisional; Region: PRK14563 655817003053 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 655817003054 active site 1 [active] 655817003055 dimer interface [polypeptide binding]; other site 655817003056 active site 2 [active] 655817003057 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 655817003058 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 655817003059 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 655817003060 outer membrane protein A; Reviewed; Region: PRK10808 655817003061 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 655817003062 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 655817003063 ligand binding site [chemical binding]; other site 655817003064 SOS cell division inhibitor; Provisional; Region: PRK10595 655817003065 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 655817003066 TfoX C-terminal domain; Region: TfoX_C; pfam04994 655817003067 TIGR01666 family membrane protein; Region: YCCS 655817003068 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 655817003069 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 655817003070 Predicted membrane protein [Function unknown]; Region: COG3304 655817003071 Domain of unknown function (DUF307); Region: DUF307; pfam03733 655817003072 Domain of unknown function (DUF307); Region: DUF307; pfam03733 655817003073 DNA helicase IV; Provisional; Region: helD; PRK11054 655817003074 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 655817003075 Part of AAA domain; Region: AAA_19; pfam13245 655817003076 Family description; Region: UvrD_C_2; pfam13538 655817003077 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 655817003078 active site 655817003079 dimer interfaces [polypeptide binding]; other site 655817003080 catalytic residues [active] 655817003081 hypothetical protein; Provisional; Region: PRK03641 655817003082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 655817003083 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 655817003084 heat shock protein HspQ; Provisional; Region: PRK14129 655817003085 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 655817003086 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 655817003087 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 655817003088 putative RNA binding site [nucleotide binding]; other site 655817003089 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817003090 S-adenosylmethionine binding site [chemical binding]; other site 655817003091 Acylphosphatase; Region: Acylphosphatase; cl00551 655817003092 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 655817003093 sulfur transfer protein TusE; Provisional; Region: PRK11508 655817003094 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 655817003095 YccA-like proteins; Region: YccA_like; cd10433 655817003096 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 655817003097 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 655817003098 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 655817003099 hydrogenase 1 large subunit; Provisional; Region: PRK10170 655817003100 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 655817003101 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 655817003102 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 655817003103 putative substrate-binding site; other site 655817003104 nickel binding site [ion binding]; other site 655817003105 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 655817003106 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 655817003107 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 655817003108 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 655817003109 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 655817003110 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 655817003111 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 655817003112 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 655817003113 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 655817003114 catalytic core [active] 655817003115 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 655817003116 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 655817003117 DNA-binding site [nucleotide binding]; DNA binding site 655817003118 RNA-binding motif; other site 655817003119 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 655817003120 DNA-binding site [nucleotide binding]; DNA binding site 655817003121 RNA-binding motif; other site 655817003122 GnsA/GnsB family; Region: GnsAB; pfam08178 655817003123 4Fe-4S binding domain; Region: Fer4_5; pfam12801 655817003124 4Fe-4S binding domain; Region: Fer4_5; pfam12801 655817003125 Ferredoxin [Energy production and conversion]; Region: NapF; COG1145 655817003126 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 655817003127 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 655817003128 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 655817003129 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 655817003130 dimerization interface [polypeptide binding]; other site 655817003131 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817003132 dimer interface [polypeptide binding]; other site 655817003133 phosphorylation site [posttranslational modification] 655817003134 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817003135 ATP binding site [chemical binding]; other site 655817003136 Mg2+ binding site [ion binding]; other site 655817003137 G-X-G motif; other site 655817003138 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817003139 active site 655817003140 phosphorylation site [posttranslational modification] 655817003141 intermolecular recognition site; other site 655817003142 dimerization interface [polypeptide binding]; other site 655817003143 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 655817003144 putative binding surface; other site 655817003145 active site 655817003146 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 655817003147 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 655817003148 putative ligand binding site [chemical binding]; other site 655817003149 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 655817003150 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817003151 active site 655817003152 phosphorylation site [posttranslational modification] 655817003153 intermolecular recognition site; other site 655817003154 dimerization interface [polypeptide binding]; other site 655817003155 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817003156 DNA binding site [nucleotide binding] 655817003157 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 655817003158 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 655817003159 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 655817003160 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 655817003161 molybdopterin cofactor binding site [chemical binding]; other site 655817003162 substrate binding site [chemical binding]; other site 655817003163 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 655817003164 molybdopterin cofactor binding site; other site 655817003165 chaperone protein TorD; Validated; Region: torD; PRK04976 655817003166 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 655817003167 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 655817003168 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 655817003169 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 655817003170 HSP70 interaction site [polypeptide binding]; other site 655817003171 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 655817003172 substrate binding site [polypeptide binding]; other site 655817003173 dimer interface [polypeptide binding]; other site 655817003174 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 655817003175 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 655817003176 catalytic core [active] 655817003177 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 655817003178 hypothetical protein; Provisional; Region: PRK10174 655817003179 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 655817003180 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 655817003181 General stress protein [General function prediction only]; Region: GsiB; COG3729 655817003182 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 655817003183 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 655817003184 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 655817003185 putative FMN binding site [chemical binding]; other site 655817003186 pyrimidine utilization protein D; Region: RutD; TIGR03611 655817003187 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 655817003188 homotrimer interaction site [polypeptide binding]; other site 655817003189 putative active site [active] 655817003190 Isochorismatase family; Region: Isochorismatase; pfam00857 655817003191 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 655817003192 catalytic triad [active] 655817003193 conserved cis-peptide bond; other site 655817003194 pyrimidine utilization protein A; Region: RutA; TIGR03612 655817003195 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 655817003196 active site 655817003197 dimer interface [polypeptide binding]; other site 655817003198 non-prolyl cis peptide bond; other site 655817003199 insertion regions; other site 655817003200 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 655817003201 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817003202 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 655817003203 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 655817003204 Predicted transcriptional regulator [Transcription]; Region: COG3905 655817003205 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 655817003206 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 655817003207 Glutamate binding site [chemical binding]; other site 655817003208 NAD binding site [chemical binding]; other site 655817003209 catalytic residues [active] 655817003210 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 655817003211 Na binding site [ion binding]; other site 655817003212 FTR1 family protein; Region: TIGR00145 655817003213 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 655817003214 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 655817003215 Imelysin; Region: Peptidase_M75; pfam09375 655817003216 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 655817003217 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 655817003218 hypothetical protein; Provisional; Region: PRK10536 655817003219 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 655817003220 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 655817003221 N-glycosyltransferase; Provisional; Region: PRK11204 655817003222 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 655817003223 DXD motif; other site 655817003224 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 655817003225 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 655817003226 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 655817003227 putative active site [active] 655817003228 putative metal binding site [ion binding]; other site 655817003229 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 655817003230 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 655817003231 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817003232 metal binding site [ion binding]; metal-binding site 655817003233 active site 655817003234 I-site; other site 655817003235 integrase; Provisional; Region: PRK09692 655817003236 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 655817003237 active site 655817003238 Int/Topo IB signature motif; other site 655817003239 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 655817003240 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 655817003241 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 655817003242 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 655817003243 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 655817003244 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 655817003245 The enzymes of glycosyl hydrolase family 31 (GH31) occur in prokaryotes, eukaryotes, and archaea with a wide range of hydrolytic activities, including alpha-glucosidase (glucoamylase and sucrase-isomaltase), alpha-xylosidase, 6-alpha-glucosyltransferase; Region: GH31; cl11402 655817003246 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 655817003247 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655817003248 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817003249 homodimer interface [polypeptide binding]; other site 655817003250 catalytic residue [active] 655817003251 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cl17181 655817003252 Tagatose 6 phosphate kinase; Region: Tagatose_6_P_K; cl09211 655817003253 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 655817003254 putative active site [active] 655817003255 potential frameshift: common BLAST hit: gi|218560205|ref|YP_002393118.1| DNA-binding transcriptional regulator AgaR 655817003256 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 655817003257 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817003258 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 655817003259 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 655817003260 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; cl17802 655817003261 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK09116 655817003262 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 655817003263 dimer interface [polypeptide binding]; other site 655817003264 active site 655817003265 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655817003266 3-oxoacyl-(acyl-carrier-protein) reductase, putative; Region: fabG_rel; TIGR01831 655817003267 NAD(P) binding site [chemical binding]; other site 655817003268 active site 655817003269 Domain of unknown function, appears to be related to a diverse group of beta-hydroxydecanoyl ACP dehydratases (FabA) and beta-hydroxyacyl ACP dehydratases (FabZ). This group appears to lack the conserved active site histidine of FabA and FabZ; Region: FabA_like; cd01289 655817003270 putative active site 1 [active] 655817003271 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK09185 655817003272 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 655817003273 dimer interface [polypeptide binding]; other site 655817003274 active site 655817003275 Protein of unknown function (DUF3261); Region: DUF3261; pfam11659 655817003276 Predicted exporter [General function prediction only]; Region: COG4258 655817003277 Outer membrane lipoprotein carrier protein LolA; Region: LolA; cl17548 655817003278 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 655817003279 active site 655817003280 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 655817003281 DPM_DPG-synthase_like is a member of the Glycosyltransferase 2 superfamily; Region: DPM_DPG-synthase_like; cd04179 655817003282 Ligand binding site; other site 655817003283 Putative Catalytic site; other site 655817003284 DXD motif; other site 655817003285 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 655817003286 putative acyl-acceptor binding pocket; other site 655817003287 The hotdog fold was initially identified in the E. coli FabA (beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase) structure and subsequently in 4HBT (4-hydroxybenzoyl-CoA thioesterase) from Pseudomonas. A number of other seemingly unrelated...; Region: hot_dog; cl00509 655817003288 active site 2 [active] 655817003289 Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases [Lipid metabolism]; Region: Acs; COG0365 655817003290 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 655817003291 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 655817003292 acyl-activating enzyme (AAE) consensus motif; other site 655817003293 acyl-activating enzyme (AAE) consensus motif; other site 655817003294 active site 655817003295 AMP binding site [chemical binding]; other site 655817003296 CoA binding site [chemical binding]; other site 655817003297 Predicted membrane protein [Function unknown]; Region: COG4648 655817003298 acyl carrier protein; Provisional; Region: PRK05350 655817003299 Phosphopantetheine attachment site; Region: PP-binding; cl09936 655817003300 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 655817003301 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 655817003302 putative acyl-acceptor binding pocket; other site 655817003303 Beta-ketoacyl synthase, N-terminal domain; Region: Ketoacyl-synt_2; pfam13723 655817003304 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817003305 S-adenosylmethionine binding site [chemical binding]; other site 655817003306 potential frameshift: common BLAST hit: gi|110644687|ref|YP_672417.1| hemagglutinin-related protein 655817003307 adhesin HecA family 20-residue repeat (two copies); Region: fil_hemag_20aa; TIGR01731 655817003308 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 655817003309 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 655817003310 Haemagluttinin repeat; Region: Fil_haemagg_2; pfam13332 655817003311 Pre-toxin domain with VENN motif; Region: PT-VENN; pfam04829 655817003312 Integrase core domain; Region: rve; pfam00665 655817003313 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 655817003314 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 655817003315 active site 655817003316 substrate binding site [chemical binding]; other site 655817003317 catalytic site [active] 655817003318 Transposase; Region: DDE_Tnp_ISL3; pfam01610 655817003319 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 655817003320 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 655817003321 Transposase; Region: DDE_Tnp_ISL3; pfam01610 655817003322 Helix-turn-helix domain; Region: HTH_38; pfam13936 655817003323 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12822 655817003324 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 655817003325 putative transposase OrfB; Reviewed; Region: PHA02517 655817003326 Integrase core domain; Region: rve; pfam00665 655817003327 Integrase core domain; Region: rve_2; pfam13333 655817003328 RTX toxin acyltransferase family; Region: HlyC; pfam02794 655817003329 HlyD family secretion protein; Region: HlyD; pfam00529 655817003330 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817003331 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817003332 ABC-type bacteriocin/lantibiotic exporters, contain an N-terminal double-glycine peptidase domain [Defense mechanisms]; Region: SunT; COG2274 655817003333 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 655817003334 putative active site [active] 655817003335 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655817003336 ATP-binding cassette domain of PrtD, subfamily C; Region: ABCC_Protease_Secretion; cd03246 655817003337 Walker A/P-loop; other site 655817003338 ATP binding site [chemical binding]; other site 655817003339 Q-loop/lid; other site 655817003340 ABC transporter signature motif; other site 655817003341 Walker B; other site 655817003342 D-loop; other site 655817003343 H-loop/switch region; other site 655817003344 CAAX protease self-immunity; Region: Abi; pfam02517 655817003345 FaeA-like protein; Region: FaeA; pfam04703 655817003346 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 655817003347 Fimbrial protein; Region: Fimbrial; cl01416 655817003348 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817003349 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 655817003350 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 655817003351 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 655817003352 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 655817003353 PapC N-terminal domain; Region: PapC_N; pfam13954 655817003354 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 655817003355 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 655817003356 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 655817003357 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 655817003358 dimer interface [polypeptide binding]; other site 655817003359 active site 655817003360 Int/Topo IB signature motif; other site 655817003361 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 655817003362 active site 655817003363 catalytic site [active] 655817003364 substrate binding site [chemical binding]; other site 655817003365 CDC45-like protein; Region: CDC45; pfam02724 655817003366 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 655817003367 transcriptional repressor DicA; Reviewed; Region: PRK09706 655817003368 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 655817003369 Pyocin large subunit [General function prediction only]; Region: COG5529 655817003370 primosomal protein DnaI; Provisional; Region: PRK02854 655817003371 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 655817003372 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 655817003373 Domain of unknown function (DUF4406); Region: DUF4406; pfam14359 655817003374 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 655817003375 Helix-turn-helix; Region: HTH_3; pfam01381 655817003376 sequence-specific DNA binding site [nucleotide binding]; other site 655817003377 salt bridge; other site 655817003378 Domain of unknown function (DUF955); Region: DUF955; cl01076 655817003379 Protein of unknown function (DUF968); Region: DUF968; pfam06147 655817003380 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 655817003381 Antitermination protein; Region: Antiterm; pfam03589 655817003382 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 655817003383 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817003384 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 655817003385 DNA methylase; Region: N6_N4_Mtase; pfam01555 655817003386 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 655817003387 tellurite resistance protein terB; Region: terB; cd07176 655817003388 putative metal binding site [ion binding]; other site 655817003389 Domain of unknown function (DUF1737); Region: DUF1737; pfam08410 655817003390 Domain of unknown function (DUF303); Region: DUF303; pfam03629 655817003391 Protein of unknown function (DUF826); Region: DUF826; pfam05696 655817003392 Lysis protein S; Region: Lysis_S; pfam04971 655817003393 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 655817003394 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 655817003395 catalytic residues [active] 655817003396 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 655817003397 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 655817003398 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 655817003399 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 655817003400 active site 655817003401 Phage terminase, small subunit [DNA replication, recombination, and repair]; Region: XtmA; COG3728 655817003402 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 655817003403 Caudovirus prohead protease; Region: Peptidase_U35; pfam04586 655817003404 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 655817003405 Phage capsid family; Region: Phage_capsid; pfam05065 655817003406 Phage-related protein [Function unknown]; Region: COG4695 655817003407 phage portal protein, HK97 family; Region: portal_HK97; TIGR01537 655817003408 Carbohydrate binding domain; Region: CBM_5_12; pfam02839 655817003409 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 655817003410 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 655817003411 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 655817003412 Immunoglobulin I-set domain; Region: I-set; pfam07679 655817003413 Immunoglobulin domain; Region: Ig_2; pfam13895 655817003414 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 655817003415 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 655817003416 Phage-related minor tail protein [Function unknown]; Region: COG5281 655817003417 tape measure domain; Region: tape_meas_nterm; TIGR02675 655817003418 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 655817003419 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 655817003420 Phage-related protein [Function unknown]; Region: COG4718 655817003421 Phage-related protein [Function unknown]; Region: gp18; COG4672 655817003422 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 655817003423 MPN+ (JAMM) motif; other site 655817003424 Zinc-binding site [ion binding]; other site 655817003425 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 655817003426 NlpC/P60 family; Region: NLPC_P60; cl17555 655817003427 Phage-related protein, tail component [Function unknown]; Region: COG4723 655817003428 Phage-related protein, tail component [Function unknown]; Region: COG4733 655817003429 Putative phage tail protein; Region: Phage-tail_3; pfam13550 655817003430 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 655817003431 Interdomain contacts; other site 655817003432 Cytokine receptor motif; other site 655817003433 Archaeal/vacuolar-type H+-ATPase subunit H [Energy production and conversion]; Region: NtpF; COG2811 655817003434 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 655817003435 Fibronectin type III protein; Region: DUF3672; pfam12421 655817003436 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 655817003437 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 655817003438 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 655817003439 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 655817003440 PapC C-terminal domain; Region: PapC_C; pfam13953 655817003441 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817003442 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817003443 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 655817003444 mannosyl binding site [chemical binding]; other site 655817003445 Fimbrial protein; Region: Fimbrial; pfam00419 655817003446 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817003447 MarR family; Region: MarR_2; cl17246 655817003448 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655817003449 Homeodomain-like domain; Region: HTH_23; pfam13384 655817003450 Winged helix-turn helix; Region: HTH_29; pfam13551 655817003451 Winged helix-turn helix; Region: HTH_33; pfam13592 655817003452 DDE superfamily endonuclease; Region: DDE_3; pfam13358 655817003453 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 655817003454 outer membrane receptor FepA; Provisional; Region: PRK13528 655817003455 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817003456 N-terminal plug; other site 655817003457 ligand-binding site [chemical binding]; other site 655817003458 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 655817003459 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 655817003460 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 655817003461 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 655817003462 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655817003463 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655817003464 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817003465 Walker A/P-loop; other site 655817003466 ATP binding site [chemical binding]; other site 655817003467 Q-loop/lid; other site 655817003468 ABC transporter signature motif; other site 655817003469 Walker B; other site 655817003470 D-loop; other site 655817003471 H-loop/switch region; other site 655817003472 lipid A export permease/ATP-binding protein MsbA; Region: MsbA_lipidA; TIGR02203 655817003473 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655817003474 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817003475 Walker A/P-loop; other site 655817003476 ATP binding site [chemical binding]; other site 655817003477 Q-loop/lid; other site 655817003478 ABC transporter signature motif; other site 655817003479 Walker B; other site 655817003480 D-loop; other site 655817003481 H-loop/switch region; other site 655817003482 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 655817003483 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 655817003484 homodimer interface [polypeptide binding]; other site 655817003485 active site 655817003486 TDP-binding site; other site 655817003487 acceptor substrate-binding pocket; other site 655817003488 Transposase IS200 like; Region: Y1_Tnp; pfam01797 655817003489 potential frameshift: common BLAST hit: gi|190014942|ref|YP_001965454.1| ISEc13 transposase 655817003490 Transposase Tn5 dimerisation domain; Region: Dimer_Tnp_Tn5; pfam02281 655817003491 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 655817003492 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817003493 N-terminal plug; other site 655817003494 ligand-binding site [chemical binding]; other site 655817003495 Domain of unknown function (DUF4198); Region: DUF4198; pfam10670 655817003496 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 655817003497 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 655817003498 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 655817003499 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 655817003500 Sel1-like repeats; Region: SEL1; smart00671 655817003501 Sel1-like repeats; Region: SEL1; smart00671 655817003502 Sel1-like repeats; Region: SEL1; smart00671 655817003503 Sel1-like repeats; Region: SEL1; smart00671 655817003504 Sel1-like repeats; Region: SEL1; smart00671 655817003505 Sel1-like repeats; Region: SEL1; smart00671 655817003506 Sel1-like repeats; Region: SEL1; smart00671 655817003507 Sel1-like repeats; Region: SEL1; smart00671 655817003508 HsdM N-terminal domain; Region: HsdM_N; pfam12161 655817003509 Predicted GTPase [General function prediction only]; Region: COG3596 655817003510 YfjP GTPase; Region: YfjP; cd11383 655817003511 G1 box; other site 655817003512 GTP/Mg2+ binding site [chemical binding]; other site 655817003513 Switch I region; other site 655817003514 G2 box; other site 655817003515 Switch II region; other site 655817003516 G3 box; other site 655817003517 G4 box; other site 655817003518 G5 box; other site 655817003519 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 655817003520 hypothetical protein; Provisional; Region: PRK09945 655817003521 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 655817003522 hypothetical protein; Provisional; Region: PRK09945 655817003523 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 655817003524 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 655817003525 Autotransporter beta-domain; Region: Autotransporter; smart00869 655817003526 Domain of unknown function (DUF932); Region: DUF932; pfam06067 655817003527 Antirestriction protein; Region: Antirestrict; pfam03230 655817003528 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 655817003529 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 655817003530 MPN+ (JAMM) motif; other site 655817003531 Zinc-binding site [ion binding]; other site 655817003532 Protein of unknown function (DUF987); Region: DUF987; pfam06174 655817003533 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 655817003534 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 655817003535 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 655817003536 Methyltransferase domain; Region: Methyltransf_27; pfam13708 655817003537 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 655817003538 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 655817003539 putative ligand binding site [chemical binding]; other site 655817003540 NAD binding site [chemical binding]; other site 655817003541 dimerization interface [polypeptide binding]; other site 655817003542 catalytic site [active] 655817003543 putative hydrolase; Validated; Region: PRK09248 655817003544 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 655817003545 active site 655817003546 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 655817003547 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 655817003548 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 655817003549 curli assembly protein CsgF; Provisional; Region: PRK10050 655817003550 curli assembly protein CsgE; Provisional; Region: PRK10386 655817003551 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 655817003552 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817003553 DNA binding residues [nucleotide binding] 655817003554 dimerization interface [polypeptide binding]; other site 655817003555 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 655817003556 Curlin associated repeat; Region: Curlin_rpt; pfam07012 655817003557 Curlin associated repeat; Region: Curlin_rpt; pfam07012 655817003558 major curlin subunit; Provisional; Region: csgA; PRK10051 655817003559 Curlin associated repeat; Region: Curlin_rpt; pfam07012 655817003560 Curlin associated repeat; Region: Curlin_rpt; pfam07012 655817003561 Thin aggregative fimbriae synthesis protein; Region: Tafi-CsgC; pfam10610 655817003562 Fimbrial protein; Region: Fimbrial; cl01416 655817003563 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 655817003564 putative ADP-ribose binding site [chemical binding]; other site 655817003565 putative active site [active] 655817003566 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 655817003567 PLD-like domain; Region: PLDc_2; pfam13091 655817003568 putative active site [active] 655817003569 catalytic site [active] 655817003570 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 655817003571 PLD-like domain; Region: PLDc_2; pfam13091 655817003572 putative active site [active] 655817003573 catalytic site [active] 655817003574 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 655817003575 Acyltransferase family; Region: Acyl_transf_3; pfam01757 655817003576 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 655817003577 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 655817003578 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 655817003579 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 655817003580 Ligand binding site; other site 655817003581 DXD motif; other site 655817003582 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 655817003583 lipoprotein; Provisional; Region: PRK10175 655817003584 secY/secA suppressor protein; Provisional; Region: PRK11467 655817003585 drug efflux system protein MdtG; Provisional; Region: PRK09874 655817003586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817003587 putative substrate translocation pore; other site 655817003588 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 655817003589 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 655817003590 putative acyl-acceptor binding pocket; other site 655817003591 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 655817003592 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 655817003593 active site residue [active] 655817003594 hypothetical protein; Provisional; Region: PRK03757 655817003595 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 655817003596 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 655817003597 hydroxyglutarate oxidase; Provisional; Region: PRK11728 655817003598 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 655817003599 DNA damage-inducible protein I; Provisional; Region: PRK10597 655817003600 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 655817003601 active site 655817003602 substrate binding pocket [chemical binding]; other site 655817003603 dimer interface [polypeptide binding]; other site 655817003604 lipoprotein; Provisional; Region: PRK10598 655817003605 glutaredoxin 2; Provisional; Region: PRK10387 655817003606 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 655817003607 C-terminal domain interface [polypeptide binding]; other site 655817003608 GSH binding site (G-site) [chemical binding]; other site 655817003609 catalytic residues [active] 655817003610 putative dimer interface [polypeptide binding]; other site 655817003611 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 655817003612 N-terminal domain interface [polypeptide binding]; other site 655817003613 multidrug resistance protein MdtH; Provisional; Region: PRK11646 655817003614 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817003615 putative substrate translocation pore; other site 655817003616 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 655817003617 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 655817003618 hypothetical protein; Provisional; Region: PRK11239 655817003619 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 655817003620 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655817003621 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655817003622 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 655817003623 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 655817003624 MviN-like protein; Region: MVIN; pfam03023 655817003625 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 655817003626 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 655817003627 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 655817003628 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 655817003629 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 655817003630 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 655817003631 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 655817003632 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 655817003633 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 655817003634 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 655817003635 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 655817003636 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 655817003637 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 655817003638 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 655817003639 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 655817003640 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 655817003641 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 655817003642 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 655817003643 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 655817003644 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 655817003645 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 655817003646 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 655817003647 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 655817003648 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 655817003649 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 655817003650 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 655817003651 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 655817003652 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 655817003653 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 655817003654 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 655817003655 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 655817003656 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 655817003657 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 655817003658 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 655817003659 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 655817003660 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 655817003661 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 655817003662 homodimer interface [polypeptide binding]; other site 655817003663 oligonucleotide binding site [chemical binding]; other site 655817003664 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 655817003665 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 655817003666 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655817003667 RNA binding surface [nucleotide binding]; other site 655817003668 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 655817003669 active site 655817003670 Maf-like protein; Region: Maf; pfam02545 655817003671 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 655817003672 active site 655817003673 dimer interface [polypeptide binding]; other site 655817003674 hypothetical protein; Provisional; Region: PRK11193 655817003675 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 655817003676 putative phosphate acyltransferase; Provisional; Region: PRK05331 655817003677 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 655817003678 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 655817003679 dimer interface [polypeptide binding]; other site 655817003680 active site 655817003681 CoA binding pocket [chemical binding]; other site 655817003682 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 655817003683 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655817003684 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 655817003685 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 655817003686 NAD(P) binding site [chemical binding]; other site 655817003687 homotetramer interface [polypeptide binding]; other site 655817003688 homodimer interface [polypeptide binding]; other site 655817003689 active site 655817003690 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 655817003691 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 655817003692 dimer interface [polypeptide binding]; other site 655817003693 active site 655817003694 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 655817003695 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 655817003696 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817003697 catalytic residue [active] 655817003698 conserved hypothetical protein, YceG family; Region: TIGR00247 655817003699 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 655817003700 dimerization interface [polypeptide binding]; other site 655817003701 thymidylate kinase; Validated; Region: tmk; PRK00698 655817003702 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 655817003703 TMP-binding site; other site 655817003704 ATP-binding site [chemical binding]; other site 655817003705 DNA polymerase III subunit delta'; Validated; Region: PRK07993 655817003706 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 655817003707 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 655817003708 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 655817003709 active site 655817003710 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 655817003711 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655817003712 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655817003713 active site turn [active] 655817003714 phosphorylation site [posttranslational modification] 655817003715 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 655817003716 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817003717 N-terminal plug; other site 655817003718 ligand-binding site [chemical binding]; other site 655817003719 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 655817003720 nucleotide binding site/active site [active] 655817003721 HIT family signature motif; other site 655817003722 catalytic residue [active] 655817003723 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 655817003724 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 655817003725 putative dimer interface [polypeptide binding]; other site 655817003726 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 655817003727 thiamine kinase; Region: ycfN_thiK; TIGR02721 655817003728 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 655817003729 active site 655817003730 substrate binding site [chemical binding]; other site 655817003731 ATP binding site [chemical binding]; other site 655817003732 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 655817003733 beta-hexosaminidase; Provisional; Region: PRK05337 655817003734 hypothetical protein; Provisional; Region: PRK04940 655817003735 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 655817003736 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817003737 hypothetical protein; Provisional; Region: PRK11280 655817003738 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655817003739 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817003740 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 655817003741 L,D-transpeptidase; Provisional; Region: PRK10260 655817003742 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655817003743 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 655817003744 transcription-repair coupling factor; Provisional; Region: PRK10689 655817003745 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 655817003746 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655817003747 ATP binding site [chemical binding]; other site 655817003748 putative Mg++ binding site [ion binding]; other site 655817003749 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817003750 nucleotide binding region [chemical binding]; other site 655817003751 ATP-binding site [chemical binding]; other site 655817003752 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 655817003753 Predicted membrane protein [Function unknown]; Region: COG4763 655817003754 Acyltransferase family; Region: Acyl_transf_3; pfam01757 655817003755 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 655817003756 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 655817003757 FtsX-like permease family; Region: FtsX; pfam02687 655817003758 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 655817003759 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 655817003760 Walker A/P-loop; other site 655817003761 ATP binding site [chemical binding]; other site 655817003762 Q-loop/lid; other site 655817003763 ABC transporter signature motif; other site 655817003764 Walker B; other site 655817003765 D-loop; other site 655817003766 H-loop/switch region; other site 655817003767 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 655817003768 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 655817003769 FtsX-like permease family; Region: FtsX; pfam02687 655817003770 fructokinase; Reviewed; Region: PRK09557 655817003771 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655817003772 nucleotide binding site [chemical binding]; other site 655817003773 NAD-dependent deacetylase; Provisional; Region: PRK00481 655817003774 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 655817003775 NAD+ binding site [chemical binding]; other site 655817003776 substrate binding site [chemical binding]; other site 655817003777 Zn binding site [ion binding]; other site 655817003778 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 655817003779 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 655817003780 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 655817003781 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 655817003782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817003783 dimer interface [polypeptide binding]; other site 655817003784 conserved gate region; other site 655817003785 putative PBP binding loops; other site 655817003786 ABC-ATPase subunit interface; other site 655817003787 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 655817003788 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817003789 dimer interface [polypeptide binding]; other site 655817003790 conserved gate region; other site 655817003791 putative PBP binding loops; other site 655817003792 ABC-ATPase subunit interface; other site 655817003793 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 655817003794 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817003795 Walker A/P-loop; other site 655817003796 ATP binding site [chemical binding]; other site 655817003797 Q-loop/lid; other site 655817003798 ABC transporter signature motif; other site 655817003799 Walker B; other site 655817003800 D-loop; other site 655817003801 H-loop/switch region; other site 655817003802 TOBE domain; Region: TOBE_2; pfam08402 655817003803 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 655817003804 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 655817003805 metal binding site [ion binding]; metal-binding site 655817003806 dimer interface [polypeptide binding]; other site 655817003807 Uncharacterized conserved protein [Function unknown]; Region: COG2850 655817003808 Cupin-like domain; Region: Cupin_8; pfam13621 655817003809 sensor protein PhoQ; Provisional; Region: PRK10815 655817003810 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 655817003811 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 655817003812 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 655817003813 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817003814 ATP binding site [chemical binding]; other site 655817003815 Mg2+ binding site [ion binding]; other site 655817003816 G-X-G motif; other site 655817003817 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 655817003818 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817003819 active site 655817003820 phosphorylation site [posttranslational modification] 655817003821 intermolecular recognition site; other site 655817003822 dimerization interface [polypeptide binding]; other site 655817003823 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817003824 DNA binding site [nucleotide binding] 655817003825 adenylosuccinate lyase; Provisional; Region: PRK09285 655817003826 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 655817003827 tetramer interface [polypeptide binding]; other site 655817003828 active site 655817003829 putative lysogenization regulator; Reviewed; Region: PRK00218 655817003830 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 655817003831 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 655817003832 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 655817003833 nudix motif; other site 655817003834 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 655817003835 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 655817003836 probable active site [active] 655817003837 isocitrate dehydrogenase; Validated; Region: PRK07362 655817003838 isocitrate dehydrogenase; Reviewed; Region: PRK07006 655817003839 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 655817003840 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 655817003841 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 655817003842 dimer interface [polypeptide binding]; other site 655817003843 active site 655817003844 Int/Topo IB signature motif; other site 655817003845 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 655817003846 ASC-1 homology or ASCH domain, a small beta-barrel domain found in all three kingdoms of life. ASCH resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as an RNA-binding domain during coactivation; Region: ASCH; cl01020 655817003847 Protein of unknown function (DUF550); Region: DUF550; pfam04447 655817003848 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 655817003849 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 655817003850 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 655817003851 phage recombination protein Bet; Region: bet_lambda; TIGR01913 655817003852 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 655817003853 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 655817003854 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 655817003855 Superinfection exclusion protein B; Region: SieB; pfam14163 655817003856 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 655817003857 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 655817003858 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655817003859 non-specific DNA binding site [nucleotide binding]; other site 655817003860 salt bridge; other site 655817003861 sequence-specific DNA binding site [nucleotide binding]; other site 655817003862 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 655817003863 Catalytic site [active] 655817003864 Bacteriophage CII protein; Region: Phage_CII; pfam05269 655817003865 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 655817003866 Replication protein P; Region: Phage_lambda_P; pfam06992 655817003867 NinB protein; Region: NinB; pfam05772 655817003868 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 655817003869 Protein of unknown function (DUF2591); Region: DUF2591; cl11584 655817003870 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 655817003871 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 655817003872 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 655817003873 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 655817003874 trimer interface [polypeptide binding]; other site 655817003875 eyelet of channel; other site 655817003876 Lysis protein S; Region: Lysis_S; pfam04971 655817003877 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 655817003878 catalytic residues [active] 655817003879 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 655817003880 Bor protein; Region: Lambda_Bor; pfam06291 655817003881 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 655817003882 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 655817003883 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 655817003884 gpW; Region: gpW; pfam02831 655817003885 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 655817003886 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 655817003887 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 655817003888 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 655817003889 tandem repeat interface [polypeptide binding]; other site 655817003890 oligomer interface [polypeptide binding]; other site 655817003891 active site residues [active] 655817003892 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 655817003893 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 655817003894 DNA packaging protein FI; Region: Packaging_FI; pfam14000 655817003895 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 655817003896 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 655817003897 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 655817003898 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 655817003899 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 655817003900 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 655817003901 Minor tail protein T; Region: Phage_tail_T; cl05636 655817003902 Phage-related minor tail protein [Function unknown]; Region: COG5281 655817003903 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 655817003904 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 655817003905 Phage-related protein [Function unknown]; Region: COG4718 655817003906 Phage-related protein [Function unknown]; Region: gp18; COG4672 655817003907 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 655817003908 MPN+ (JAMM) motif; other site 655817003909 Zinc-binding site [ion binding]; other site 655817003910 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 655817003911 NlpC/P60 family; Region: NLPC_P60; cl17555 655817003912 Phage-related protein, tail component [Function unknown]; Region: COG4723 655817003913 Phage-related protein, tail component [Function unknown]; Region: COG4733 655817003914 Putative phage tail protein; Region: Phage-tail_3; pfam13550 655817003915 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 655817003916 Interdomain contacts; other site 655817003917 Cytokine receptor motif; other site 655817003918 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 655817003919 Fibronectin type III protein; Region: DUF3672; pfam12421 655817003920 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 655817003921 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 655817003922 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 655817003923 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817003924 ABC-ATPase subunit interface; other site 655817003925 dimer interface [polypeptide binding]; other site 655817003926 putative PBP binding regions; other site 655817003927 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 655817003928 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817003929 ABC-ATPase subunit interface; other site 655817003930 dimer interface [polypeptide binding]; other site 655817003931 putative PBP binding regions; other site 655817003932 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 655817003933 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 655817003934 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 655817003935 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 655817003936 metal binding site [ion binding]; metal-binding site 655817003937 Isocitrate/isopropylmalate dehydrogenase; Region: Iso_dh; cl00445 655817003938 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 655817003939 transcriptional regulator MirA; Provisional; Region: PRK15043 655817003940 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 655817003941 DNA binding residues [nucleotide binding] 655817003942 Sensors of blue-light using FAD; Region: BLUF; smart01034 655817003943 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817003944 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 655817003945 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 655817003946 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817003947 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 655817003948 Autotransporter beta-domain; Region: Autotransporter; cl17461 655817003949 Autotransporter beta-domain; Region: Autotransporter; smart00869 655817003950 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 655817003951 cell division inhibitor MinD; Provisional; Region: PRK10818 655817003952 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 655817003953 Switch I; other site 655817003954 Switch II; other site 655817003955 septum formation inhibitor; Reviewed; Region: minC; PRK03511 655817003956 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 655817003957 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 655817003958 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 655817003959 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 655817003960 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 655817003961 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 655817003962 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 655817003963 hypothetical protein; Provisional; Region: PRK10691 655817003964 hypothetical protein; Provisional; Region: PRK05170 655817003965 Haemolysin E (HlyE); Region: HlyE; cl11627 655817003966 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 655817003967 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 655817003968 Catalytic site [active] 655817003969 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 655817003970 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 655817003971 active site 655817003972 DNA binding site [nucleotide binding] 655817003973 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 655817003974 disulfide bond formation protein B; Provisional; Region: PRK01749 655817003975 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 655817003976 transmembrane helices; other site 655817003977 fatty acid metabolism regulator; Provisional; Region: PRK04984 655817003978 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817003979 DNA-binding site [nucleotide binding]; DNA binding site 655817003980 FadR C-terminal domain; Region: FadR_C; pfam07840 655817003981 SpoVR family protein; Provisional; Region: PRK11767 655817003982 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 655817003983 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 655817003984 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817003985 alanine racemase; Reviewed; Region: dadX; PRK03646 655817003986 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 655817003987 active site 655817003988 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 655817003989 substrate binding site [chemical binding]; other site 655817003990 catalytic residues [active] 655817003991 dimer interface [polypeptide binding]; other site 655817003992 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 655817003993 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 655817003994 TrkA-C domain; Region: TrkA_C; pfam02080 655817003995 Transporter associated domain; Region: CorC_HlyC; smart01091 655817003996 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 655817003997 dimer interface [polypeptide binding]; other site 655817003998 catalytic triad [active] 655817003999 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 655817004000 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 655817004001 N-acetyl-D-glucosamine binding site [chemical binding]; other site 655817004002 catalytic residue [active] 655817004003 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 655817004004 Flagellar regulator YcgR; Region: YcgR; pfam07317 655817004005 PilZ domain; Region: PilZ; pfam07238 655817004006 hypothetical protein; Provisional; Region: PRK10457 655817004007 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817004008 N-terminal plug; other site 655817004009 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 655817004010 ligand-binding site [chemical binding]; other site 655817004011 molybdenum transport protein ModD; Provisional; Region: PRK06096 655817004012 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 655817004013 dimerization interface [polypeptide binding]; other site 655817004014 active site 655817004015 Methyltransferase domain; Region: Methyltransf_31; pfam13847 655817004016 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817004017 S-adenosylmethionine binding site [chemical binding]; other site 655817004018 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 655817004019 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655817004020 Walker A/P-loop; other site 655817004021 ATP binding site [chemical binding]; other site 655817004022 Q-loop/lid; other site 655817004023 ABC transporter signature motif; other site 655817004024 Walker B; other site 655817004025 D-loop; other site 655817004026 H-loop/switch region; other site 655817004027 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 655817004028 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817004029 ABC-ATPase subunit interface; other site 655817004030 dimer interface [polypeptide binding]; other site 655817004031 putative PBP binding regions; other site 655817004032 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 655817004033 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 655817004034 putative metal binding site [ion binding]; other site 655817004035 trehalase; Provisional; Region: treA; PRK13271 655817004036 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 655817004037 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 655817004038 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 655817004039 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 655817004040 dimerization domain swap beta strand [polypeptide binding]; other site 655817004041 regulatory protein interface [polypeptide binding]; other site 655817004042 active site 655817004043 regulatory phosphorylation site [posttranslational modification]; other site 655817004044 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 655817004045 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 655817004046 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 655817004047 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 655817004048 Dak1 domain; Region: Dak1; pfam02733 655817004049 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 655817004050 PAS domain; Region: PAS; smart00091 655817004051 putative active site [active] 655817004052 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817004053 Walker A motif; other site 655817004054 ATP binding site [chemical binding]; other site 655817004055 Walker B motif; other site 655817004056 arginine finger; other site 655817004057 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 655817004058 Probable pectinesterase/pectinesterase inhibitor; Region: PLN02708 655817004059 GTP-binding protein YchF; Reviewed; Region: PRK09601 655817004060 YchF GTPase; Region: YchF; cd01900 655817004061 G1 box; other site 655817004062 GTP/Mg2+ binding site [chemical binding]; other site 655817004063 Switch I region; other site 655817004064 G2 box; other site 655817004065 Switch II region; other site 655817004066 G3 box; other site 655817004067 G4 box; other site 655817004068 G5 box; other site 655817004069 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 655817004070 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 655817004071 putative active site [active] 655817004072 catalytic residue [active] 655817004073 hypothetical protein; Provisional; Region: PRK10692 655817004074 putative transporter; Provisional; Region: PRK11660 655817004075 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 655817004076 Sulfate transporter family; Region: Sulfate_transp; pfam00916 655817004077 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 655817004078 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 655817004079 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 655817004080 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655817004081 active site 655817004082 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 655817004083 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 655817004084 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 655817004085 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 655817004086 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 655817004087 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 655817004088 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 655817004089 tRNA; other site 655817004090 putative tRNA binding site [nucleotide binding]; other site 655817004091 putative NADP binding site [chemical binding]; other site 655817004092 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 655817004093 peptide chain release factor 1; Validated; Region: prfA; PRK00591 655817004094 This domain is found in peptide chain release factors; Region: PCRF; smart00937 655817004095 RF-1 domain; Region: RF-1; pfam00472 655817004096 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 655817004097 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817004098 hypothetical protein; Provisional; Region: PRK10278 655817004099 hypothetical protein; Provisional; Region: PRK10941 655817004100 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 655817004101 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 655817004102 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 655817004103 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 655817004104 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 655817004105 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 655817004106 cation transport regulator; Reviewed; Region: chaB; PRK09582 655817004107 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 655817004108 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 655817004109 putative active site pocket [active] 655817004110 dimerization interface [polypeptide binding]; other site 655817004111 putative catalytic residue [active] 655817004112 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 655817004113 putative invasin; Provisional; Region: PRK10177 655817004114 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 655817004115 transcriptional regulator NarL; Provisional; Region: PRK10651 655817004116 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817004117 active site 655817004118 phosphorylation site [posttranslational modification] 655817004119 intermolecular recognition site; other site 655817004120 dimerization interface [polypeptide binding]; other site 655817004121 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817004122 DNA binding residues [nucleotide binding] 655817004123 dimerization interface [polypeptide binding]; other site 655817004124 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 655817004125 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 655817004126 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655817004127 dimerization interface [polypeptide binding]; other site 655817004128 Histidine kinase; Region: HisKA_3; pfam07730 655817004129 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817004130 ATP binding site [chemical binding]; other site 655817004131 Mg2+ binding site [ion binding]; other site 655817004132 G-X-G motif; other site 655817004133 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 655817004134 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 655817004135 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 655817004136 [4Fe-4S] binding site [ion binding]; other site 655817004137 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 655817004138 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 655817004139 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 655817004140 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 655817004141 molybdopterin cofactor binding site; other site 655817004142 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 655817004143 4Fe-4S binding domain; Region: Fer4; cl02805 655817004144 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 655817004145 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 655817004146 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK07204 655817004147 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 655817004148 dimer interface [polypeptide binding]; other site 655817004149 active site 655817004150 CoA binding pocket [chemical binding]; other site 655817004151 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 655817004152 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655817004153 NAD(P) binding site [chemical binding]; other site 655817004154 active site 655817004155 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 655817004156 Coenzyme F390 synthetase [Coenzyme metabolism]; Region: PaaK; COG1541 655817004157 putative adenylate-forming enzyme; Region: aden_form_hyp; TIGR02304 655817004158 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 655817004159 active site 655817004160 Sterol desaturase [Lipid metabolism]; Region: ERG3; COG3000 655817004161 Fatty acid hydroxylase superfamily; Region: FA_hydroxylase; pfam04116 655817004162 The Delta6 Fatty Acid Desaturase (Delta6-FADS)-like CD includes the integral-membrane enzymes: delta-4, delta-5, delta-6, delta-8, delta-8-sphingolipid, and delta-11 desaturases found in vertebrates, higher plants, fungi, and bacteria. These desaturases...; Region: Delta6-FADS-like; cd03506 655817004163 putative di-iron ligands [ion binding]; other site 655817004164 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 655817004165 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 655817004166 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 655817004167 putative active site [active] 655817004168 putative substrate binding site [chemical binding]; other site 655817004169 putative cosubstrate binding site; other site 655817004170 catalytic site [active] 655817004171 SEC-C motif; Region: SEC-C; pfam02810 655817004172 hypothetical protein; Provisional; Region: PRK04233 655817004173 hypothetical protein; Provisional; Region: PRK10279 655817004174 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 655817004175 active site 655817004176 nucleophile elbow; other site 655817004177 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817004178 active site 655817004179 response regulator of RpoS; Provisional; Region: PRK10693 655817004180 phosphorylation site [posttranslational modification] 655817004181 intermolecular recognition site; other site 655817004182 dimerization interface [polypeptide binding]; other site 655817004183 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 655817004184 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 655817004185 active site 655817004186 tetramer interface; other site 655817004187 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 655817004188 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 655817004189 thymidine kinase; Provisional; Region: PRK04296 655817004190 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 655817004191 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 655817004192 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 655817004193 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 655817004194 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 655817004195 putative catalytic cysteine [active] 655817004196 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 655817004197 putative active site [active] 655817004198 metal binding site [ion binding]; metal-binding site 655817004199 hypothetical protein; Provisional; Region: PRK11111 655817004200 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 655817004201 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 655817004202 peptide binding site [polypeptide binding]; other site 655817004203 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 655817004204 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817004205 dimer interface [polypeptide binding]; other site 655817004206 conserved gate region; other site 655817004207 putative PBP binding loops; other site 655817004208 ABC-ATPase subunit interface; other site 655817004209 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 655817004210 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 655817004211 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817004212 dimer interface [polypeptide binding]; other site 655817004213 conserved gate region; other site 655817004214 putative PBP binding loops; other site 655817004215 ABC-ATPase subunit interface; other site 655817004216 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 655817004217 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817004218 Walker A/P-loop; other site 655817004219 ATP binding site [chemical binding]; other site 655817004220 Q-loop/lid; other site 655817004221 ABC transporter signature motif; other site 655817004222 Walker B; other site 655817004223 D-loop; other site 655817004224 H-loop/switch region; other site 655817004225 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 655817004226 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 655817004227 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817004228 Walker A/P-loop; other site 655817004229 ATP binding site [chemical binding]; other site 655817004230 Q-loop/lid; other site 655817004231 ABC transporter signature motif; other site 655817004232 Walker B; other site 655817004233 D-loop; other site 655817004234 H-loop/switch region; other site 655817004235 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 655817004236 dsDNA-mimic protein; Reviewed; Region: PRK05094 655817004237 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 655817004238 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 655817004239 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 655817004240 putative active site [active] 655817004241 catalytic site [active] 655817004242 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 655817004243 putative active site [active] 655817004244 catalytic site [active] 655817004245 voltage-gated potassium channel; Provisional; Region: PRK10537 655817004246 Ion channel; Region: Ion_trans_2; pfam07885 655817004247 TrkA-N domain; Region: TrkA_N; pfam02254 655817004248 YciI-like protein; Reviewed; Region: PRK11370 655817004249 transport protein TonB; Provisional; Region: PRK10819 655817004250 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 655817004251 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 655817004252 intracellular septation protein A; Reviewed; Region: PRK00259 655817004253 hypothetical protein; Provisional; Region: PRK02868 655817004254 outer membrane protein W; Provisional; Region: PRK10959 655817004255 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 655817004256 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 655817004257 dimerization interface [polypeptide binding]; other site 655817004258 metal binding site [ion binding]; metal-binding site 655817004259 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 655817004260 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 655817004261 substrate binding site [chemical binding]; other site 655817004262 active site 655817004263 catalytic residues [active] 655817004264 heterodimer interface [polypeptide binding]; other site 655817004265 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 655817004266 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 655817004267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817004268 catalytic residue [active] 655817004269 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 655817004270 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 655817004271 active site 655817004272 ribulose/triose binding site [chemical binding]; other site 655817004273 phosphate binding site [ion binding]; other site 655817004274 substrate (anthranilate) binding pocket [chemical binding]; other site 655817004275 product (indole) binding pocket [chemical binding]; other site 655817004276 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 655817004277 active site 655817004278 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 655817004279 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 655817004280 glutamine binding [chemical binding]; other site 655817004281 catalytic triad [active] 655817004282 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 655817004283 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 655817004284 anthranilate synthase component I; Provisional; Region: PRK13564 655817004285 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 655817004286 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 655817004287 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 655817004288 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 655817004289 active site 655817004290 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 655817004291 hypothetical protein; Provisional; Region: PRK11630 655817004292 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 655817004293 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 655817004294 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655817004295 RNA binding surface [nucleotide binding]; other site 655817004296 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 655817004297 probable active site [active] 655817004298 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 655817004299 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 655817004300 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 655817004301 homodimer interface [polypeptide binding]; other site 655817004302 Walker A motif; other site 655817004303 ATP binding site [chemical binding]; other site 655817004304 hydroxycobalamin binding site [chemical binding]; other site 655817004305 Walker B motif; other site 655817004306 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 655817004307 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 655817004308 NADP binding site [chemical binding]; other site 655817004309 homodimer interface [polypeptide binding]; other site 655817004310 active site 655817004311 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 655817004312 putative inner membrane peptidase; Provisional; Region: PRK11778 655817004313 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 655817004314 tandem repeat interface [polypeptide binding]; other site 655817004315 oligomer interface [polypeptide binding]; other site 655817004316 active site residues [active] 655817004317 hypothetical protein; Provisional; Region: PRK11037 655817004318 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 655817004319 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 655817004320 active site 655817004321 interdomain interaction site; other site 655817004322 putative metal-binding site [ion binding]; other site 655817004323 nucleotide binding site [chemical binding]; other site 655817004324 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 655817004325 domain I; other site 655817004326 DNA binding groove [nucleotide binding] 655817004327 phosphate binding site [ion binding]; other site 655817004328 domain II; other site 655817004329 domain III; other site 655817004330 nucleotide binding site [chemical binding]; other site 655817004331 catalytic site [active] 655817004332 domain IV; other site 655817004333 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 655817004334 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 655817004335 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 655817004336 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 655817004337 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 655817004338 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817004339 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 655817004340 substrate binding site [chemical binding]; other site 655817004341 putative dimerization interface [polypeptide binding]; other site 655817004342 aconitate hydratase; Validated; Region: PRK09277 655817004343 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 655817004344 substrate binding site [chemical binding]; other site 655817004345 ligand binding site [chemical binding]; other site 655817004346 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 655817004347 substrate binding site [chemical binding]; other site 655817004348 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 655817004349 dimerization interface [polypeptide binding]; other site 655817004350 active site 655817004351 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 655817004352 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 655817004353 active site 655817004354 Predicted membrane protein [Function unknown]; Region: COG3771 655817004355 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 655817004356 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 655817004357 TPR motif; other site 655817004358 binding surface 655817004359 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655817004360 binding surface 655817004361 TPR motif; other site 655817004362 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 655817004363 active site 655817004364 dimer interface [polypeptide binding]; other site 655817004365 translation initiation factor Sui1; Validated; Region: PRK06824 655817004366 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 655817004367 putative rRNA binding site [nucleotide binding]; other site 655817004368 lipoprotein; Provisional; Region: PRK10540 655817004369 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655817004370 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 655817004371 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817004372 hypothetical protein; Provisional; Region: PRK13658 655817004373 RNase II stability modulator; Provisional; Region: PRK10060 655817004374 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655817004375 putative active site [active] 655817004376 heme pocket [chemical binding]; other site 655817004377 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817004378 metal binding site [ion binding]; metal-binding site 655817004379 active site 655817004380 I-site; other site 655817004381 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817004382 exoribonuclease II; Provisional; Region: PRK05054 655817004383 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 655817004384 RNB domain; Region: RNB; pfam00773 655817004385 S1 RNA binding domain; Region: S1; pfam00575 655817004386 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 655817004387 Uncharacterized conserved protein [Function unknown]; Region: COG2128 655817004388 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 655817004389 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 655817004390 NAD binding site [chemical binding]; other site 655817004391 homotetramer interface [polypeptide binding]; other site 655817004392 homodimer interface [polypeptide binding]; other site 655817004393 substrate binding site [chemical binding]; other site 655817004394 active site 655817004395 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655817004396 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817004397 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 655817004398 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817004399 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817004400 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 655817004401 Protein export membrane protein; Region: SecD_SecF; cl14618 655817004402 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 655817004403 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 655817004404 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817004405 putative substrate translocation pore; other site 655817004406 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 655817004407 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817004408 Walker A/P-loop; other site 655817004409 ATP binding site [chemical binding]; other site 655817004410 Q-loop/lid; other site 655817004411 ABC transporter signature motif; other site 655817004412 Walker B; other site 655817004413 D-loop; other site 655817004414 H-loop/switch region; other site 655817004415 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 655817004416 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817004417 Walker A/P-loop; other site 655817004418 ATP binding site [chemical binding]; other site 655817004419 Q-loop/lid; other site 655817004420 ABC transporter signature motif; other site 655817004421 Walker B; other site 655817004422 D-loop; other site 655817004423 H-loop/switch region; other site 655817004424 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 655817004425 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 655817004426 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 655817004427 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817004428 dimer interface [polypeptide binding]; other site 655817004429 conserved gate region; other site 655817004430 putative PBP binding loops; other site 655817004431 ABC-ATPase subunit interface; other site 655817004432 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 655817004433 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817004434 dimer interface [polypeptide binding]; other site 655817004435 conserved gate region; other site 655817004436 putative PBP binding loops; other site 655817004437 ABC-ATPase subunit interface; other site 655817004438 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 655817004439 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 655817004440 peptide binding site [polypeptide binding]; other site 655817004441 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 655817004442 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 655817004443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817004444 Walker A motif; other site 655817004445 ATP binding site [chemical binding]; other site 655817004446 Walker B motif; other site 655817004447 arginine finger; other site 655817004448 phage shock protein PspA; Provisional; Region: PRK10698 655817004449 phage shock protein B; Provisional; Region: pspB; PRK09458 655817004450 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 655817004451 phage shock protein C; Region: phageshock_pspC; TIGR02978 655817004452 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 655817004453 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 655817004454 active site residue [active] 655817004455 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 655817004456 sucrose phosphorylase; Provisional; Region: PRK13840 655817004457 active site 655817004458 homodimer interface [polypeptide binding]; other site 655817004459 catalytic site [active] 655817004460 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 655817004461 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 655817004462 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 655817004463 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817004464 dimer interface [polypeptide binding]; other site 655817004465 conserved gate region; other site 655817004466 putative PBP binding loops; other site 655817004467 ABC-ATPase subunit interface; other site 655817004468 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655817004469 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817004470 dimer interface [polypeptide binding]; other site 655817004471 conserved gate region; other site 655817004472 putative PBP binding loops; other site 655817004473 ABC-ATPase subunit interface; other site 655817004474 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655817004475 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 655817004476 putative NAD(P) binding site [chemical binding]; other site 655817004477 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 655817004478 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655817004479 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655817004480 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 655817004481 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 655817004482 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 655817004483 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 655817004484 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 655817004485 beta-phosphoglucomutase; Region: bPGM; TIGR01990 655817004486 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817004487 motif II; other site 655817004488 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 655817004489 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 655817004490 Walker A/P-loop; other site 655817004491 ATP binding site [chemical binding]; other site 655817004492 Q-loop/lid; other site 655817004493 ABC transporter signature motif; other site 655817004494 Walker B; other site 655817004495 D-loop; other site 655817004496 H-loop/switch region; other site 655817004497 TOBE domain; Region: TOBE_2; pfam08402 655817004498 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 655817004499 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655817004500 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817004501 DNA binding site [nucleotide binding] 655817004502 domain linker motif; other site 655817004503 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 655817004504 putative dimerization interface [polypeptide binding]; other site 655817004505 putative ligand binding site [chemical binding]; other site 655817004506 Predicted ATPase [General function prediction only]; Region: COG3106 655817004507 hypothetical protein; Provisional; Region: PRK05415 655817004508 TIGR01620 family protein; Region: hyp_HI0043 655817004509 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 655817004510 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 655817004511 putative aromatic amino acid binding site; other site 655817004512 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817004513 Walker A motif; other site 655817004514 ATP binding site [chemical binding]; other site 655817004515 Walker B motif; other site 655817004516 arginine finger; other site 655817004517 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 655817004518 dimer interface [polypeptide binding]; other site 655817004519 catalytic triad [active] 655817004520 peroxidatic and resolving cysteines [active] 655817004521 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 655817004522 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 655817004523 active site 655817004524 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 655817004525 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 655817004526 putative active site [active] 655817004527 Zn binding site [ion binding]; other site 655817004528 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 655817004529 NADH(P)-binding; Region: NAD_binding_10; pfam13460 655817004530 putative NAD(P) binding site [chemical binding]; other site 655817004531 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 655817004532 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 655817004533 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655817004534 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817004535 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 655817004536 putative effector binding pocket; other site 655817004537 putative dimerization interface [polypeptide binding]; other site 655817004538 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 655817004539 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 655817004540 peptide binding site [polypeptide binding]; other site 655817004541 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 655817004542 Mechanosensitive ion channel; Region: MS_channel; pfam00924 655817004543 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 655817004544 universal stress protein UspE; Provisional; Region: PRK11175 655817004545 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 655817004546 Ligand Binding Site [chemical binding]; other site 655817004547 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 655817004548 Ligand Binding Site [chemical binding]; other site 655817004549 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 655817004550 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 655817004551 ligand binding site [chemical binding]; other site 655817004552 flexible hinge region; other site 655817004553 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 655817004554 putative switch regulator; other site 655817004555 non-specific DNA interactions [nucleotide binding]; other site 655817004556 DNA binding site [nucleotide binding] 655817004557 sequence specific DNA binding site [nucleotide binding]; other site 655817004558 putative cAMP binding site [chemical binding]; other site 655817004559 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 655817004560 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 655817004561 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 655817004562 DNA binding site [nucleotide binding] 655817004563 active site 655817004564 Helix-turn-helix domain; Region: HTH_18; pfam12833 655817004565 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817004566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 655817004567 Smr domain; Region: Smr; pfam01713 655817004568 PAS domain S-box; Region: sensory_box; TIGR00229 655817004569 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655817004570 putative active site [active] 655817004571 heme pocket [chemical binding]; other site 655817004572 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 655817004573 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817004574 metal binding site [ion binding]; metal-binding site 655817004575 active site 655817004576 I-site; other site 655817004577 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 655817004578 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 655817004579 Cl binding site [ion binding]; other site 655817004580 oligomer interface [polypeptide binding]; other site 655817004581 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 655817004582 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 655817004583 ATP binding site [chemical binding]; other site 655817004584 Mg++ binding site [ion binding]; other site 655817004585 motif III; other site 655817004586 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817004587 nucleotide binding region [chemical binding]; other site 655817004588 ATP-binding site [chemical binding]; other site 655817004589 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 655817004590 putative RNA binding site [nucleotide binding]; other site 655817004591 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 655817004592 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 655817004593 Ligand Binding Site [chemical binding]; other site 655817004594 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 655817004595 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 655817004596 DNA binding site [nucleotide binding] 655817004597 active site 655817004598 Int/Topo IB signature motif; other site 655817004599 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cl00462 655817004600 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 655817004601 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 655817004602 Ligand Binding Site [chemical binding]; other site 655817004603 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 655817004604 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 655817004605 trimer interface [polypeptide binding]; other site 655817004606 eyelet of channel; other site 655817004607 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 655817004608 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 655817004609 dimer interface [polypeptide binding]; other site 655817004610 PYR/PP interface [polypeptide binding]; other site 655817004611 TPP binding site [chemical binding]; other site 655817004612 substrate binding site [chemical binding]; other site 655817004613 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 655817004614 Domain of unknown function; Region: EKR; smart00890 655817004615 4Fe-4S binding domain; Region: Fer4_6; pfam12837 655817004616 4Fe-4S binding domain; Region: Fer4; pfam00037 655817004617 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 655817004618 TPP-binding site [chemical binding]; other site 655817004619 dimer interface [polypeptide binding]; other site 655817004620 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 655817004621 Domain of unknown function (DUF333); Region: DUF333; pfam03891 655817004622 heat-inducible protein; Provisional; Region: PRK10449 655817004623 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 655817004624 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 655817004625 putative ligand binding site [chemical binding]; other site 655817004626 putative NAD binding site [chemical binding]; other site 655817004627 catalytic site [active] 655817004628 hypothetical protein; Provisional; Region: PRK10695 655817004629 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 655817004630 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 655817004631 Autotransporter beta-domain; Region: Autotransporter; pfam03797 655817004632 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655817004633 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655817004634 active site 655817004635 catalytic tetrad [active] 655817004636 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 655817004637 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 655817004638 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 655817004639 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 655817004640 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 655817004641 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817004642 S-adenosylmethionine binding site [chemical binding]; other site 655817004643 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 655817004644 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 655817004645 active site 655817004646 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 655817004647 active site 655817004648 catalytic residues [active] 655817004649 azoreductase; Reviewed; Region: PRK00170 655817004650 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 655817004651 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 655817004652 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655817004653 ATP binding site [chemical binding]; other site 655817004654 putative Mg++ binding site [ion binding]; other site 655817004655 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817004656 nucleotide binding region [chemical binding]; other site 655817004657 ATP-binding site [chemical binding]; other site 655817004658 Helicase associated domain (HA2); Region: HA2; pfam04408 655817004659 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 655817004660 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 655817004661 Uncharacterized conserved protein [Function unknown]; Region: COG1434 655817004662 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 655817004663 putative active site [active] 655817004664 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 655817004665 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655817004666 NAD binding site [chemical binding]; other site 655817004667 catalytic residues [active] 655817004668 substrate binding site [chemical binding]; other site 655817004669 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 655817004670 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 655817004671 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 655817004672 cytochrome b561; Provisional; Region: PRK11513 655817004673 hypothetical protein; Provisional; Region: PRK10040 655817004674 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655817004675 dimer interface [polypeptide binding]; other site 655817004676 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 655817004677 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817004678 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655817004679 dimerization interface [polypeptide binding]; other site 655817004680 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 655817004681 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 655817004682 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 655817004683 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 655817004684 hypothetical protein; Provisional; Region: PRK11415 655817004685 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 655817004686 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655817004687 Coenzyme A binding pocket [chemical binding]; other site 655817004688 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 655817004689 putative trimer interface [polypeptide binding]; other site 655817004690 putative CoA binding site [chemical binding]; other site 655817004691 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 655817004692 putative trimer interface [polypeptide binding]; other site 655817004693 putative CoA binding site [chemical binding]; other site 655817004694 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 655817004695 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 655817004696 gating phenylalanine in ion channel; other site 655817004697 tellurite resistance protein TehB; Provisional; Region: PRK11207 655817004698 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817004699 S-adenosylmethionine binding site [chemical binding]; other site 655817004700 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 655817004701 benzoate transporter; Region: benE; TIGR00843 655817004702 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 655817004703 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 655817004704 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655817004705 non-specific DNA binding site [nucleotide binding]; other site 655817004706 salt bridge; other site 655817004707 sequence-specific DNA binding site [nucleotide binding]; other site 655817004708 Cupin domain; Region: Cupin_2; pfam07883 655817004709 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 655817004710 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 655817004711 Peptidase family U32; Region: Peptidase_U32; pfam01136 655817004712 Collagenase; Region: DUF3656; pfam12392 655817004713 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 655817004714 Helix-turn-helix; Region: HTH_3; pfam01381 655817004715 sequence-specific DNA binding site [nucleotide binding]; other site 655817004716 salt bridge; other site 655817004717 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655817004718 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817004719 DNA-binding site [nucleotide binding]; DNA binding site 655817004720 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655817004721 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817004722 homodimer interface [polypeptide binding]; other site 655817004723 catalytic residue [active] 655817004724 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 655817004725 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 655817004726 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 655817004727 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817004728 Walker A/P-loop; other site 655817004729 ATP binding site [chemical binding]; other site 655817004730 Q-loop/lid; other site 655817004731 ABC transporter signature motif; other site 655817004732 Walker B; other site 655817004733 D-loop; other site 655817004734 H-loop/switch region; other site 655817004735 TOBE domain; Region: TOBE_2; pfam08402 655817004736 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817004737 dimer interface [polypeptide binding]; other site 655817004738 conserved gate region; other site 655817004739 putative PBP binding loops; other site 655817004740 ABC-ATPase subunit interface; other site 655817004741 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 655817004742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817004743 ABC-ATPase subunit interface; other site 655817004744 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 655817004745 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 655817004746 tetrameric interface [polypeptide binding]; other site 655817004747 NAD binding site [chemical binding]; other site 655817004748 catalytic residues [active] 655817004749 substrate binding site [chemical binding]; other site 655817004750 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 655817004751 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 655817004752 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 655817004753 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 655817004754 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 655817004755 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 655817004756 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 655817004757 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817004758 N-terminal plug; other site 655817004759 ligand-binding site [chemical binding]; other site 655817004760 PQQ-like domain; Region: PQQ_2; pfam13360 655817004761 L-asparagine permease; Provisional; Region: PRK15049 655817004762 Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold; Region: Thioredoxin_like; cl00388 655817004763 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 655817004764 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 655817004765 dimer interface [polypeptide binding]; other site 655817004766 substrate binding pocket (H-site) [chemical binding]; other site 655817004767 N-terminal domain interface [polypeptide binding]; other site 655817004768 PAAR motif; Region: PAAR_motif; pfam05488 655817004769 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 655817004770 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 655817004771 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 655817004772 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 655817004773 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; cl01733 655817004774 Domain of unknown function (DUF4123); Region: DUF4123; pfam13503 655817004775 PAAR motif; Region: PAAR_motif; pfam05488 655817004776 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 655817004777 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 655817004778 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 655817004779 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 655817004780 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 655817004781 putative active site [active] 655817004782 putative Zn binding site [ion binding]; other site 655817004783 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; cl17880 655817004784 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 655817004785 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 655817004786 hypothetical protein; Provisional; Region: PRK10281 655817004787 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 655817004788 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 655817004789 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 655817004790 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 655817004791 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 655817004792 [4Fe-4S] binding site [ion binding]; other site 655817004793 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 655817004794 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 655817004795 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 655817004796 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 655817004797 molybdopterin cofactor binding site; other site 655817004798 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 655817004799 aromatic amino acid exporter; Provisional; Region: PRK11689 655817004800 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 655817004801 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 655817004802 [4Fe-4S] binding site [ion binding]; other site 655817004803 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 655817004804 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 655817004805 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 655817004806 molybdopterin cofactor binding site; other site 655817004807 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 655817004808 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 655817004809 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 655817004810 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 655817004811 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 655817004812 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655817004813 non-specific DNA binding site [nucleotide binding]; other site 655817004814 salt bridge; other site 655817004815 sequence-specific DNA binding site [nucleotide binding]; other site 655817004816 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 655817004817 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 655817004818 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 655817004819 NAD binding site [chemical binding]; other site 655817004820 substrate binding site [chemical binding]; other site 655817004821 catalytic Zn binding site [ion binding]; other site 655817004822 tetramer interface [polypeptide binding]; other site 655817004823 structural Zn binding site [ion binding]; other site 655817004824 malate dehydrogenase; Provisional; Region: PRK13529 655817004825 Malic enzyme, N-terminal domain; Region: malic; pfam00390 655817004826 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 655817004827 NAD(P) binding site [chemical binding]; other site 655817004828 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 655817004829 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 655817004830 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 655817004831 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 655817004832 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655817004833 putative active site [active] 655817004834 heme pocket [chemical binding]; other site 655817004835 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655817004836 putative active site [active] 655817004837 heme pocket [chemical binding]; other site 655817004838 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817004839 metal binding site [ion binding]; metal-binding site 655817004840 active site 655817004841 I-site; other site 655817004842 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817004843 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 655817004844 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817004845 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 655817004846 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 655817004847 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 655817004848 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 655817004849 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817004850 catalytic residue [active] 655817004851 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 655817004852 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 655817004853 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 655817004854 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 655817004855 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 655817004856 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 655817004857 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 655817004858 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 655817004859 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 655817004860 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 655817004861 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 655817004862 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817004863 FeS/SAM binding site; other site 655817004864 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 655817004865 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 655817004866 Sulfatase; Region: Sulfatase; pfam00884 655817004867 transcriptional regulator YdeO; Provisional; Region: PRK09940 655817004868 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817004869 putative oxidoreductase; Provisional; Region: PRK09939 655817004870 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 655817004871 putative molybdopterin cofactor binding site [chemical binding]; other site 655817004872 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 655817004873 putative molybdopterin cofactor binding site; other site 655817004874 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 655817004875 mannosyl binding site [chemical binding]; other site 655817004876 Fimbrial protein; Region: Fimbrial; pfam00419 655817004877 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817004878 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817004879 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 655817004880 PapC N-terminal domain; Region: PapC_N; pfam13954 655817004881 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 655817004882 PapC C-terminal domain; Region: PapC_C; pfam13953 655817004883 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 655817004884 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 655817004885 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 655817004886 Fimbrial protein; Region: Fimbrial; cl01416 655817004887 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655817004888 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655817004889 dimerization interface [polypeptide binding]; other site 655817004890 HipA N-terminal domain; Region: Couple_hipA; pfam13657 655817004891 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 655817004892 HipA-like N-terminal domain; Region: HipA_N; pfam07805 655817004893 HipA-like C-terminal domain; Region: HipA_C; pfam07804 655817004894 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 655817004895 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655817004896 non-specific DNA binding site [nucleotide binding]; other site 655817004897 salt bridge; other site 655817004898 sequence-specific DNA binding site [nucleotide binding]; other site 655817004899 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 655817004900 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817004901 S-adenosylmethionine binding site [chemical binding]; other site 655817004902 Predicted membrane protein [Function unknown]; Region: COG3781 655817004903 altronate oxidoreductase; Provisional; Region: PRK03643 655817004904 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 655817004905 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 655817004906 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 655817004907 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817004908 metal binding site [ion binding]; metal-binding site 655817004909 active site 655817004910 I-site; other site 655817004911 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 655817004912 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 655817004913 glutaminase; Provisional; Region: PRK00971 655817004914 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 655817004915 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 655817004916 NAD(P) binding site [chemical binding]; other site 655817004917 catalytic residues [active] 655817004918 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655817004919 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817004920 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 655817004921 putative dimerization interface [polypeptide binding]; other site 655817004922 putative arabinose transporter; Provisional; Region: PRK03545 655817004923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817004924 putative substrate translocation pore; other site 655817004925 inner membrane protein; Provisional; Region: PRK10995 655817004926 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 655817004927 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655817004928 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 655817004929 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817004930 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817004931 hypothetical protein; Provisional; Region: PRK10106 655817004932 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 655817004933 beta-galactosidase; Region: BGL; TIGR03356 655817004934 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 655817004935 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 655817004936 trimer interface; other site 655817004937 sugar binding site [chemical binding]; other site 655817004938 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 655817004939 active site 655817004940 methionine cluster; other site 655817004941 phosphorylation site [posttranslational modification] 655817004942 metal binding site [ion binding]; metal-binding site 655817004943 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 655817004944 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 655817004945 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 655817004946 active site 655817004947 P-loop; other site 655817004948 phosphorylation site [posttranslational modification] 655817004949 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 655817004950 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817004951 DNA-binding site [nucleotide binding]; DNA binding site 655817004952 UTRA domain; Region: UTRA; pfam07702 655817004953 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 655817004954 EamA-like transporter family; Region: EamA; pfam00892 655817004955 EamA-like transporter family; Region: EamA; pfam00892 655817004956 putative transporter; Provisional; Region: PRK10054 655817004957 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817004958 putative substrate translocation pore; other site 655817004959 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817004960 metal binding site [ion binding]; metal-binding site 655817004961 active site 655817004962 I-site; other site 655817004963 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 655817004964 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 655817004965 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 655817004966 active site 655817004967 Zn binding site [ion binding]; other site 655817004968 malonic semialdehyde reductase; Provisional; Region: PRK10538 655817004969 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 655817004970 putative NAD(P) binding site [chemical binding]; other site 655817004971 homodimer interface [polypeptide binding]; other site 655817004972 homotetramer interface [polypeptide binding]; other site 655817004973 active site 655817004974 Transcriptional regulators [Transcription]; Region: GntR; COG1802 655817004975 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817004976 DNA-binding site [nucleotide binding]; DNA binding site 655817004977 FCD domain; Region: FCD; pfam07729 655817004978 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 655817004979 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 655817004980 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 655817004981 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 655817004982 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817004983 metabolite-proton symporter; Region: 2A0106; TIGR00883 655817004984 putative substrate translocation pore; other site 655817004985 putative oxidoreductase; Provisional; Region: PRK10083 655817004986 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 655817004987 putative NAD(P) binding site [chemical binding]; other site 655817004988 catalytic Zn binding site [ion binding]; other site 655817004989 structural Zn binding site [ion binding]; other site 655817004990 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 655817004991 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 655817004992 putative active site pocket [active] 655817004993 putative metal binding site [ion binding]; other site 655817004994 hypothetical protein; Provisional; Region: PRK02237 655817004995 hypothetical protein; Provisional; Region: PRK13659 655817004996 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 655817004997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655817004998 Coenzyme A binding pocket [chemical binding]; other site 655817004999 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 655817005000 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 655817005001 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 655817005002 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 655817005003 putative [Fe4-S4] binding site [ion binding]; other site 655817005004 putative molybdopterin cofactor binding site [chemical binding]; other site 655817005005 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 655817005006 putative molybdopterin cofactor binding site; other site 655817005007 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 655817005008 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 655817005009 putative [Fe4-S4] binding site [ion binding]; other site 655817005010 putative molybdopterin cofactor binding site [chemical binding]; other site 655817005011 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 655817005012 putative molybdopterin cofactor binding site; other site 655817005013 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 655817005014 4Fe-4S binding domain; Region: Fer4; cl02805 655817005015 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 655817005016 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 655817005017 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 655817005018 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 655817005019 Cl- selectivity filter; other site 655817005020 Cl- binding residues [ion binding]; other site 655817005021 pore gating glutamate residue; other site 655817005022 dimer interface [polypeptide binding]; other site 655817005023 putative dithiobiotin synthetase; Provisional; Region: PRK12374 655817005024 AAA domain; Region: AAA_26; pfam13500 655817005025 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 655817005026 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 655817005027 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655817005028 nucleotide binding site [chemical binding]; other site 655817005029 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 655817005030 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817005031 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 655817005032 dimerization interface [polypeptide binding]; other site 655817005033 substrate binding pocket [chemical binding]; other site 655817005034 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 655817005035 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817005036 putative substrate translocation pore; other site 655817005037 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 655817005038 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 655817005039 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 655817005040 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 655817005041 Domain of unknown function DUF20; Region: UPF0118; pfam01594 655817005042 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 655817005043 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 655817005044 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 655817005045 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 655817005046 ligand binding site [chemical binding]; other site 655817005047 homodimer interface [polypeptide binding]; other site 655817005048 NAD(P) binding site [chemical binding]; other site 655817005049 trimer interface B [polypeptide binding]; other site 655817005050 trimer interface A [polypeptide binding]; other site 655817005051 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 655817005052 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 655817005053 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 655817005054 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 655817005055 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 655817005056 Spore germination protein; Region: Spore_permease; cl17796 655817005057 dihydromonapterin reductase; Provisional; Region: PRK06483 655817005058 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 655817005059 NADP binding site [chemical binding]; other site 655817005060 substrate binding pocket [chemical binding]; other site 655817005061 active site 655817005062 GlpM protein; Region: GlpM; pfam06942 655817005063 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 655817005064 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817005065 active site 655817005066 phosphorylation site [posttranslational modification] 655817005067 intermolecular recognition site; other site 655817005068 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817005069 DNA binding site [nucleotide binding] 655817005070 sensor protein RstB; Provisional; Region: PRK10604 655817005071 Mor transcription activator family; Region: Mor; pfam08765 655817005072 Protein of unknown function (DUF1018); Region: DUF1018; pfam06252 655817005073 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in a group of uncharacterized proteins from bacteria and archaea; Region: NTP-PPase_u2; cd11539 655817005074 metal binding site [ion binding]; metal-binding site 655817005075 Bacteriophage Mu Gam like protein; Region: Phage_Mu_Gam; cl01825 655817005076 Type II secretory pathway, component ExeA (predicted ATPase) [Intracellular trafficking and secretion]; Region: ExeA; COG3267 655817005077 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817005078 Walker A/P-loop; other site 655817005079 ATP binding site [chemical binding]; other site 655817005080 Integrase core domain; Region: rve; pfam00665 655817005081 IclR helix-turn-helix domain; Region: HTH_IclR; cl17605 655817005082 phage-associated protein, BcepMu gp16 family; Region: BcepMu_gp16; TIGR04111 655817005083 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dam; COG0338 655817005084 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 655817005085 Protein of unknown function (DUF4063); Region: DUF4063; pfam13272 655817005086 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 655817005087 N-acetyl-D-glucosamine binding site [chemical binding]; other site 655817005088 catalytic residue [active] 655817005089 chromosome segregation protein SMC, common bacterial type; Region: SMC_prok_B; TIGR02168 655817005090 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK06476 655817005091 acetolactate synthase 3 catalytic subunit; Reviewed; Region: PRK06048 655817005092 Protein of unknown function (DUF3486); Region: DUF3486; pfam11985 655817005093 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 655817005094 Protein of unknown function (DUF935); Region: DUF935; pfam06074 655817005095 Phage Mu protein F like protein; Region: Phage_Mu_F; pfam04233 655817005096 Phage virion morphogenesis family; Region: Phage_tail_S; cl02089 655817005097 Protein of unknown function (DUF1320); Region: DUF1320; pfam07030 655817005098 Gp37 protein; Region: Gp37; pfam09646 655817005099 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 655817005100 Phage tail tube protein FII; Region: Phage_tube; cl01390 655817005101 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 655817005102 Phage-related minor tail protein; Region: PhageMin_Tail; pfam10145 655817005103 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 655817005104 Phage Tail Protein X; Region: Phage_tail_X; pfam05489 655817005105 Phage protein D [General function prediction only]; Region: COG3500 655817005106 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 655817005107 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 655817005108 Phage baseplate assembly protein W [General function prediction only]; Region: COG3628 655817005109 Baseplate J-like protein; Region: Baseplate_J; cl01294 655817005110 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 655817005111 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 655817005112 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 655817005113 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 655817005114 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 655817005115 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 655817005116 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 655817005117 Phage Tail Collar Domain; Region: Collar; pfam07484 655817005118 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 655817005119 Phage Tail Collar Domain; Region: Collar; pfam07484 655817005120 multiple promoter invertase; Provisional; Region: mpi; PRK13413 655817005121 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 655817005122 catalytic residues [active] 655817005123 catalytic nucleophile [active] 655817005124 Presynaptic Site I dimer interface [polypeptide binding]; other site 655817005125 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 655817005126 Synaptic Flat tetramer interface [polypeptide binding]; other site 655817005127 Synaptic Site I dimer interface [polypeptide binding]; other site 655817005128 DNA binding site [nucleotide binding] 655817005129 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 655817005130 DNA-binding interface [nucleotide binding]; DNA binding site 655817005131 sensor protein RstB; Provisional; Region: PRK10604 655817005132 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655817005133 dimerization interface [polypeptide binding]; other site 655817005134 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817005135 dimer interface [polypeptide binding]; other site 655817005136 phosphorylation site [posttranslational modification] 655817005137 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817005138 ATP binding site [chemical binding]; other site 655817005139 Mg2+ binding site [ion binding]; other site 655817005140 G-X-G motif; other site 655817005141 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 655817005142 fumarate hydratase; Reviewed; Region: fumC; PRK00485 655817005143 Class II fumarases; Region: Fumarase_classII; cd01362 655817005144 active site 655817005145 tetramer interface [polypeptide binding]; other site 655817005146 fumarate hydratase; Provisional; Region: PRK15389 655817005147 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 655817005148 Fumarase C-terminus; Region: Fumerase_C; pfam05683 655817005149 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 655817005150 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 655817005151 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 655817005152 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 655817005153 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 655817005154 putative outer membrane porin protein; Provisional; Region: PRK11379 655817005155 glucuronide transporter; Provisional; Region: PRK09848 655817005156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817005157 putative substrate translocation pore; other site 655817005158 beta-D-glucuronidase; Provisional; Region: PRK10150 655817005159 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 655817005160 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 655817005161 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 655817005162 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655817005163 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817005164 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 655817005165 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 655817005166 NAD binding site [chemical binding]; other site 655817005167 substrate binding site [chemical binding]; other site 655817005168 homotetramer interface [polypeptide binding]; other site 655817005169 homodimer interface [polypeptide binding]; other site 655817005170 active site 655817005171 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 655817005172 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817005173 DNA binding site [nucleotide binding] 655817005174 domain linker motif; other site 655817005175 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 655817005176 putative dimerization interface [polypeptide binding]; other site 655817005177 putative ligand binding site [chemical binding]; other site 655817005178 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 655817005179 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 655817005180 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655817005181 active site turn [active] 655817005182 phosphorylation site [posttranslational modification] 655817005183 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 655817005184 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655817005185 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817005186 homodimer interface [polypeptide binding]; other site 655817005187 catalytic residue [active] 655817005188 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 655817005189 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 655817005190 active site 655817005191 purine riboside binding site [chemical binding]; other site 655817005192 putative oxidoreductase; Provisional; Region: PRK11579 655817005193 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655817005194 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 655817005195 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 655817005196 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 655817005197 electron transport complex protein RsxA; Provisional; Region: PRK05151 655817005198 electron transport complex protein RnfB; Provisional; Region: PRK05113 655817005199 Putative Fe-S cluster; Region: FeS; pfam04060 655817005200 4Fe-4S binding domain; Region: Fer4; pfam00037 655817005201 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 655817005202 SLBB domain; Region: SLBB; pfam10531 655817005203 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 655817005204 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 655817005205 electron transport complex protein RnfG; Validated; Region: PRK01908 655817005206 electron transport complex RsxE subunit; Provisional; Region: PRK12405 655817005207 endonuclease III; Provisional; Region: PRK10702 655817005208 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 655817005209 minor groove reading motif; other site 655817005210 helix-hairpin-helix signature motif; other site 655817005211 substrate binding pocket [chemical binding]; other site 655817005212 active site 655817005213 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 655817005214 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 655817005215 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817005216 putative substrate translocation pore; other site 655817005217 POT family; Region: PTR2; pfam00854 655817005218 glutathionine S-transferase; Provisional; Region: PRK10542 655817005219 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 655817005220 C-terminal domain interface [polypeptide binding]; other site 655817005221 GSH binding site (G-site) [chemical binding]; other site 655817005222 dimer interface [polypeptide binding]; other site 655817005223 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 655817005224 N-terminal domain interface [polypeptide binding]; other site 655817005225 dimer interface [polypeptide binding]; other site 655817005226 substrate binding pocket (H-site) [chemical binding]; other site 655817005227 pyridoxamine kinase; Validated; Region: PRK05756 655817005228 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 655817005229 dimer interface [polypeptide binding]; other site 655817005230 pyridoxal binding site [chemical binding]; other site 655817005231 ATP binding site [chemical binding]; other site 655817005232 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 655817005233 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 655817005234 active site 655817005235 HIGH motif; other site 655817005236 dimer interface [polypeptide binding]; other site 655817005237 KMSKS motif; other site 655817005238 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655817005239 RNA binding surface [nucleotide binding]; other site 655817005240 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 655817005241 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 655817005242 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 655817005243 lysozyme inhibitor; Provisional; Region: PRK11372 655817005244 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 655817005245 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 655817005246 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 655817005247 transcriptional regulator SlyA; Provisional; Region: PRK03573 655817005248 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 655817005249 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 655817005250 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 655817005251 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817005252 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817005253 Fusaric acid resistance protein family; Region: FUSC; pfam04632 655817005254 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 655817005255 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 655817005256 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 655817005257 E-class dimer interface [polypeptide binding]; other site 655817005258 P-class dimer interface [polypeptide binding]; other site 655817005259 active site 655817005260 Cu2+ binding site [ion binding]; other site 655817005261 Zn2+ binding site [ion binding]; other site 655817005262 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655817005263 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655817005264 active site 655817005265 catalytic tetrad [active] 655817005266 Predicted Fe-S protein [General function prediction only]; Region: COG3313 655817005267 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655817005268 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817005269 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 655817005270 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 655817005271 FMN binding site [chemical binding]; other site 655817005272 active site 655817005273 substrate binding site [chemical binding]; other site 655817005274 catalytic residue [active] 655817005275 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655817005276 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 655817005277 dimer interface [polypeptide binding]; other site 655817005278 active site 655817005279 metal binding site [ion binding]; metal-binding site 655817005280 glutathione binding site [chemical binding]; other site 655817005281 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 655817005282 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 655817005283 dimer interface [polypeptide binding]; other site 655817005284 catalytic site [active] 655817005285 putative active site [active] 655817005286 putative substrate binding site [chemical binding]; other site 655817005287 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 655817005288 putative GSH binding site [chemical binding]; other site 655817005289 catalytic residues [active] 655817005290 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 655817005291 NlpC/P60 family; Region: NLPC_P60; pfam00877 655817005292 superoxide dismutase; Provisional; Region: PRK10543 655817005293 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 655817005294 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 655817005295 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817005296 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655817005297 putative substrate translocation pore; other site 655817005298 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 655817005299 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817005300 DNA binding site [nucleotide binding] 655817005301 domain linker motif; other site 655817005302 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 655817005303 dimerization interface [polypeptide binding]; other site 655817005304 ligand binding site [chemical binding]; other site 655817005305 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 655817005306 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817005307 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655817005308 dimerization interface [polypeptide binding]; other site 655817005309 putative transporter; Provisional; Region: PRK11043 655817005310 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817005311 putative substrate translocation pore; other site 655817005312 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 655817005313 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 655817005314 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817005315 S-adenosylmethionine binding site [chemical binding]; other site 655817005316 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 655817005317 Lumazine binding domain; Region: Lum_binding; pfam00677 655817005318 Lumazine binding domain; Region: Lum_binding; pfam00677 655817005319 multidrug efflux protein; Reviewed; Region: PRK01766 655817005320 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 655817005321 cation binding site [ion binding]; other site 655817005322 hypothetical protein; Provisional; Region: PRK09945 655817005323 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 655817005324 putative monooxygenase; Provisional; Region: PRK11118 655817005325 hypothetical protein; Provisional; Region: PRK09897 655817005326 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 655817005327 hypothetical protein; Provisional; Region: PRK09946 655817005328 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 655817005329 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 655817005330 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 655817005331 hypothetical protein; Provisional; Region: PRK09947 655817005332 putative oxidoreductase; Provisional; Region: PRK09849 655817005333 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 655817005334 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 655817005335 hypothetical protein; Provisional; Region: PRK09898 655817005336 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 655817005337 hypothetical protein; Provisional; Region: PRK10292 655817005338 pyruvate kinase; Provisional; Region: PRK09206 655817005339 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 655817005340 active site 655817005341 domain interfaces; other site 655817005342 murein lipoprotein; Provisional; Region: PRK15396 655817005343 L,D-transpeptidase; Provisional; Region: PRK10190 655817005344 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655817005345 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 655817005346 cysteine desufuration protein SufE; Provisional; Region: PRK09296 655817005347 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 655817005348 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 655817005349 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655817005350 catalytic residue [active] 655817005351 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 655817005352 FeS assembly protein SufD; Region: sufD; TIGR01981 655817005353 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 655817005354 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 655817005355 Walker A/P-loop; other site 655817005356 ATP binding site [chemical binding]; other site 655817005357 Q-loop/lid; other site 655817005358 ABC transporter signature motif; other site 655817005359 Walker B; other site 655817005360 D-loop; other site 655817005361 H-loop/switch region; other site 655817005362 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 655817005363 putative ABC transporter; Region: ycf24; CHL00085 655817005364 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 655817005365 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 655817005366 CoenzymeA binding site [chemical binding]; other site 655817005367 subunit interaction site [polypeptide binding]; other site 655817005368 PHB binding site; other site 655817005369 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 655817005370 FAD binding domain; Region: FAD_binding_4; pfam01565 655817005371 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 655817005372 putative inner membrane protein; Provisional; Region: PRK10983 655817005373 Domain of unknown function DUF20; Region: UPF0118; pfam01594 655817005374 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 655817005375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817005376 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655817005377 putative substrate translocation pore; other site 655817005378 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817005379 putative substrate translocation pore; other site 655817005380 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 655817005381 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 655817005382 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 655817005383 shikimate binding site; other site 655817005384 NAD(P) binding site [chemical binding]; other site 655817005385 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 655817005386 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 655817005387 active site 655817005388 catalytic residue [active] 655817005389 dimer interface [polypeptide binding]; other site 655817005390 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 655817005391 Coenzyme A transferase; Region: CoA_trans; smart00882 655817005392 Coenzyme A transferase; Region: CoA_trans; cl17247 655817005393 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 655817005394 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 655817005395 active site 655817005396 Cupin domain; Region: Cupin_2; pfam07883 655817005397 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 655817005398 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655817005399 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817005400 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 655817005401 Ligand binding site [chemical binding]; other site 655817005402 Electron transfer flavoprotein domain; Region: ETF; pfam01012 655817005403 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 655817005404 Electron transfer flavoprotein domain; Region: ETF; smart00893 655817005405 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 655817005406 oxidoreductase; Provisional; Region: PRK10015 655817005407 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 655817005408 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 655817005409 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 655817005410 acyl-activating enzyme (AAE) consensus motif; other site 655817005411 putative AMP binding site [chemical binding]; other site 655817005412 putative active site [active] 655817005413 putative CoA binding site [chemical binding]; other site 655817005414 phosphoenolpyruvate synthase; Validated; Region: PRK06464 655817005415 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 655817005416 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 655817005417 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 655817005418 PEP synthetase regulatory protein; Provisional; Region: PRK05339 655817005419 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 655817005420 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 655817005421 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 655817005422 Uncharacterized conserved protein [Function unknown]; Region: COG0397 655817005423 hypothetical protein; Validated; Region: PRK00029 655817005424 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 655817005425 NlpC/P60 family; Region: NLPC_P60; pfam00877 655817005426 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 655817005427 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655817005428 Walker A/P-loop; other site 655817005429 ATP binding site [chemical binding]; other site 655817005430 Q-loop/lid; other site 655817005431 ABC transporter signature motif; other site 655817005432 Walker B; other site 655817005433 D-loop; other site 655817005434 H-loop/switch region; other site 655817005435 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 655817005436 catalytic residues [active] 655817005437 dimer interface [polypeptide binding]; other site 655817005438 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 655817005439 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817005440 ABC-ATPase subunit interface; other site 655817005441 dimer interface [polypeptide binding]; other site 655817005442 putative PBP binding regions; other site 655817005443 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 655817005444 IHF dimer interface [polypeptide binding]; other site 655817005445 IHF - DNA interface [nucleotide binding]; other site 655817005446 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 655817005447 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 655817005448 putative tRNA-binding site [nucleotide binding]; other site 655817005449 B3/4 domain; Region: B3_4; pfam03483 655817005450 tRNA synthetase B5 domain; Region: B5; smart00874 655817005451 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 655817005452 dimer interface [polypeptide binding]; other site 655817005453 motif 1; other site 655817005454 motif 3; other site 655817005455 motif 2; other site 655817005456 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 655817005457 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 655817005458 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 655817005459 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 655817005460 dimer interface [polypeptide binding]; other site 655817005461 motif 1; other site 655817005462 active site 655817005463 motif 2; other site 655817005464 motif 3; other site 655817005465 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 655817005466 23S rRNA binding site [nucleotide binding]; other site 655817005467 L21 binding site [polypeptide binding]; other site 655817005468 L13 binding site [polypeptide binding]; other site 655817005469 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 655817005470 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 655817005471 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 655817005472 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 655817005473 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 655817005474 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 655817005475 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 655817005476 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 655817005477 active site 655817005478 dimer interface [polypeptide binding]; other site 655817005479 motif 1; other site 655817005480 motif 2; other site 655817005481 motif 3; other site 655817005482 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 655817005483 anticodon binding site; other site 655817005484 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 655817005485 6-phosphofructokinase 2; Provisional; Region: PRK10294 655817005486 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 655817005487 putative substrate binding site [chemical binding]; other site 655817005488 putative ATP binding site [chemical binding]; other site 655817005489 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 655817005490 Phosphotransferase enzyme family; Region: APH; pfam01636 655817005491 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 655817005492 active site 655817005493 ATP binding site [chemical binding]; other site 655817005494 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 655817005495 YniB-like protein; Region: YniB; pfam14002 655817005496 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 655817005497 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 655817005498 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817005499 motif II; other site 655817005500 inner membrane protein; Provisional; Region: PRK11648 655817005501 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 655817005502 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 655817005503 cell division modulator; Provisional; Region: PRK10113 655817005504 hydroperoxidase II; Provisional; Region: katE; PRK11249 655817005505 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 655817005506 tetramer interface [polypeptide binding]; other site 655817005507 heme binding pocket [chemical binding]; other site 655817005508 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 655817005509 domain interactions; other site 655817005510 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 655817005511 putative active site [active] 655817005512 YdjC motif; other site 655817005513 Mg binding site [ion binding]; other site 655817005514 putative homodimer interface [polypeptide binding]; other site 655817005515 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 655817005516 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 655817005517 NAD binding site [chemical binding]; other site 655817005518 sugar binding site [chemical binding]; other site 655817005519 divalent metal binding site [ion binding]; other site 655817005520 tetramer (dimer of dimers) interface [polypeptide binding]; other site 655817005521 dimer interface [polypeptide binding]; other site 655817005522 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 655817005523 Cupin domain; Region: Cupin_2; pfam07883 655817005524 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817005525 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 655817005526 methionine cluster; other site 655817005527 active site 655817005528 phosphorylation site [posttranslational modification] 655817005529 metal binding site [ion binding]; metal-binding site 655817005530 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 655817005531 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 655817005532 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 655817005533 active site 655817005534 P-loop; other site 655817005535 phosphorylation site [posttranslational modification] 655817005536 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 655817005537 NAD+ synthetase; Region: nadE; TIGR00552 655817005538 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 655817005539 homodimer interface [polypeptide binding]; other site 655817005540 NAD binding pocket [chemical binding]; other site 655817005541 ATP binding pocket [chemical binding]; other site 655817005542 Mg binding site [ion binding]; other site 655817005543 active-site loop [active] 655817005544 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 655817005545 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 655817005546 GIY-YIG motif/motif A; other site 655817005547 active site 655817005548 catalytic site [active] 655817005549 putative DNA binding site [nucleotide binding]; other site 655817005550 metal binding site [ion binding]; metal-binding site 655817005551 hypothetical protein; Provisional; Region: PRK11396 655817005552 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 655817005553 dimer interface [polypeptide binding]; other site 655817005554 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 655817005555 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 655817005556 putative active site [active] 655817005557 Zn binding site [ion binding]; other site 655817005558 succinylarginine dihydrolase; Provisional; Region: PRK13281 655817005559 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 655817005560 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 655817005561 NAD(P) binding site [chemical binding]; other site 655817005562 catalytic residues [active] 655817005563 arginine succinyltransferase; Provisional; Region: PRK10456 655817005564 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 655817005565 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 655817005566 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655817005567 inhibitor-cofactor binding pocket; inhibition site 655817005568 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817005569 catalytic residue [active] 655817005570 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 655817005571 putative catalytic site [active] 655817005572 putative phosphate binding site [ion binding]; other site 655817005573 active site 655817005574 metal binding site A [ion binding]; metal-binding site 655817005575 DNA binding site [nucleotide binding] 655817005576 putative AP binding site [nucleotide binding]; other site 655817005577 putative metal binding site B [ion binding]; other site 655817005578 Uncharacterized conserved protein [Function unknown]; Region: COG0398 655817005579 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 655817005580 Uncharacterized conserved protein [Function unknown]; Region: COG0398 655817005581 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 655817005582 Uncharacterized conserved protein [Function unknown]; Region: COG2128 655817005583 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 655817005584 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 655817005585 hypothetical protein; Provisional; Region: PRK11622 655817005586 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 655817005587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817005588 dimer interface [polypeptide binding]; other site 655817005589 conserved gate region; other site 655817005590 putative PBP binding loops; other site 655817005591 ABC-ATPase subunit interface; other site 655817005592 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 655817005593 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817005594 Walker A/P-loop; other site 655817005595 ATP binding site [chemical binding]; other site 655817005596 Q-loop/lid; other site 655817005597 ABC transporter signature motif; other site 655817005598 Walker B; other site 655817005599 D-loop; other site 655817005600 H-loop/switch region; other site 655817005601 Rhodanese Homology Domain; Region: RHOD; smart00450 655817005602 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 655817005603 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 655817005604 active site residue [active] 655817005605 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 655817005606 active site residue [active] 655817005607 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 655817005608 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 655817005609 active site 655817005610 8-oxo-dGMP binding site [chemical binding]; other site 655817005611 nudix motif; other site 655817005612 metal binding site [ion binding]; metal-binding site 655817005613 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 655817005614 glutamate dehydrogenase; Provisional; Region: PRK09414 655817005615 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 655817005616 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 655817005617 NAD(P) binding site [chemical binding]; other site 655817005618 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 655817005619 HSP70 interaction site [polypeptide binding]; other site 655817005620 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 655817005621 Sel1-like repeats; Region: SEL1; smart00671 655817005622 Sel1-like repeats; Region: SEL1; smart00671 655817005623 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 655817005624 Sel1-like repeats; Region: SEL1; smart00671 655817005625 Sel1-like repeats; Region: SEL1; smart00671 655817005626 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 655817005627 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 655817005628 nucleotide binding site [chemical binding]; other site 655817005629 putative NEF/HSP70 interaction site [polypeptide binding]; other site 655817005630 SBD interface [polypeptide binding]; other site 655817005631 DNA topoisomerase III; Provisional; Region: PRK07726 655817005632 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 655817005633 active site 655817005634 putative interdomain interaction site [polypeptide binding]; other site 655817005635 putative metal-binding site [ion binding]; other site 655817005636 putative nucleotide binding site [chemical binding]; other site 655817005637 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 655817005638 domain I; other site 655817005639 DNA binding groove [nucleotide binding] 655817005640 phosphate binding site [ion binding]; other site 655817005641 domain II; other site 655817005642 domain III; other site 655817005643 nucleotide binding site [chemical binding]; other site 655817005644 catalytic site [active] 655817005645 domain IV; other site 655817005646 selenophosphate synthetase; Provisional; Region: PRK00943 655817005647 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 655817005648 dimerization interface [polypeptide binding]; other site 655817005649 putative ATP binding site [chemical binding]; other site 655817005650 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 655817005651 putative FMN binding site [chemical binding]; other site 655817005652 protease 4; Provisional; Region: PRK10949 655817005653 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 655817005654 tandem repeat interface [polypeptide binding]; other site 655817005655 oligomer interface [polypeptide binding]; other site 655817005656 active site residues [active] 655817005657 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 655817005658 tandem repeat interface [polypeptide binding]; other site 655817005659 oligomer interface [polypeptide binding]; other site 655817005660 active site residues [active] 655817005661 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 655817005662 active site 655817005663 homodimer interface [polypeptide binding]; other site 655817005664 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 655817005665 Isochorismatase family; Region: Isochorismatase; pfam00857 655817005666 catalytic triad [active] 655817005667 metal binding site [ion binding]; metal-binding site 655817005668 conserved cis-peptide bond; other site 655817005669 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 655817005670 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817005671 putative substrate translocation pore; other site 655817005672 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817005673 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655817005674 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 655817005675 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817005676 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655817005677 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655817005678 active site 655817005679 catalytic tetrad [active] 655817005680 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655817005681 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 655817005682 substrate binding site [chemical binding]; other site 655817005683 ATP binding site [chemical binding]; other site 655817005684 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 655817005685 intersubunit interface [polypeptide binding]; other site 655817005686 active site 655817005687 zinc binding site [ion binding]; other site 655817005688 Na+ binding site [ion binding]; other site 655817005689 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655817005690 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 655817005691 inhibitor binding site; inhibition site 655817005692 catalytic Zn binding site [ion binding]; other site 655817005693 structural Zn binding site [ion binding]; other site 655817005694 NADP binding site [chemical binding]; other site 655817005695 tetramer interface [polypeptide binding]; other site 655817005696 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817005697 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817005698 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655817005699 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 655817005700 putative NAD(P) binding site [chemical binding]; other site 655817005701 catalytic Zn binding site [ion binding]; other site 655817005702 structural Zn binding site [ion binding]; other site 655817005703 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 655817005704 methionine sulfoxide reductase B; Provisional; Region: PRK00222 655817005705 SelR domain; Region: SelR; pfam01641 655817005706 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 655817005707 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 655817005708 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 655817005709 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 655817005710 active site 655817005711 phosphate binding residues; other site 655817005712 catalytic residues [active] 655817005713 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655817005714 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655817005715 active site 655817005716 catalytic tetrad [active] 655817005717 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 655817005718 PrkA family serine protein kinase; Provisional; Region: PRK15455 655817005719 AAA ATPase domain; Region: AAA_16; pfam13191 655817005720 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 655817005721 hypothetical protein; Provisional; Region: PRK05325 655817005722 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 655817005723 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817005724 metal binding site [ion binding]; metal-binding site 655817005725 active site 655817005726 I-site; other site 655817005727 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 655817005728 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817005729 metal binding site [ion binding]; metal-binding site 655817005730 active site 655817005731 I-site; other site 655817005732 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 655817005733 putative deacylase active site [active] 655817005734 Predicted membrane protein [Function unknown]; Region: COG2707 655817005735 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655817005736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817005737 cyanate transporter; Region: CynX; TIGR00896 655817005738 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817005739 Uncharacterized conserved protein [Function unknown]; Region: COG3189 655817005740 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 655817005741 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 655817005742 Domain of unknown function (DUF333); Region: DUF333; pfam03891 655817005743 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 655817005744 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 655817005745 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 655817005746 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817005747 metal binding site [ion binding]; metal-binding site 655817005748 active site 655817005749 I-site; other site 655817005750 hypothetical protein; Provisional; Region: PRK10457 655817005751 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 655817005752 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 655817005753 leucine export protein LeuE; Provisional; Region: PRK10958 655817005754 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655817005755 ribonuclease D; Provisional; Region: PRK10829 655817005756 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 655817005757 catalytic site [active] 655817005758 putative active site [active] 655817005759 putative substrate binding site [chemical binding]; other site 655817005760 Helicase and RNase D C-terminal; Region: HRDC; smart00341 655817005761 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 655817005762 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 655817005763 acyl-activating enzyme (AAE) consensus motif; other site 655817005764 putative AMP binding site [chemical binding]; other site 655817005765 putative active site [active] 655817005766 putative CoA binding site [chemical binding]; other site 655817005767 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 655817005768 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 655817005769 Glycoprotease family; Region: Peptidase_M22; pfam00814 655817005770 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 655817005771 DEAD/DEAH box helicase; Region: DEAD; pfam00270 655817005772 DEAD_2; Region: DEAD_2; pfam06733 655817005773 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 655817005774 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 655817005775 homotrimer interaction site [polypeptide binding]; other site 655817005776 putative active site [active] 655817005777 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 655817005778 hypothetical protein; Provisional; Region: PRK05114 655817005779 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 655817005780 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 655817005781 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 655817005782 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 655817005783 putative active site [active] 655817005784 putative CoA binding site [chemical binding]; other site 655817005785 nudix motif; other site 655817005786 metal binding site [ion binding]; metal-binding site 655817005787 L-serine deaminase; Provisional; Region: PRK15023 655817005788 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 655817005789 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 655817005790 phage resistance protein; Provisional; Region: PRK10551 655817005791 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 655817005792 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817005793 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 655817005794 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 655817005795 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 655817005796 Transporter associated domain; Region: CorC_HlyC; smart01091 655817005797 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 655817005798 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 655817005799 active pocket/dimerization site; other site 655817005800 active site 655817005801 phosphorylation site [posttranslational modification] 655817005802 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 655817005803 active site 655817005804 phosphorylation site [posttranslational modification] 655817005805 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 655817005806 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 655817005807 Predicted membrane protein [Function unknown]; Region: COG4811 655817005808 hypothetical protein; Provisional; Region: PRK11469 655817005809 Domain of unknown function DUF; Region: DUF204; pfam02659 655817005810 Domain of unknown function DUF; Region: DUF204; pfam02659 655817005811 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 655817005812 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817005813 S-adenosylmethionine binding site [chemical binding]; other site 655817005814 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 655817005815 DNA-binding site [nucleotide binding]; DNA binding site 655817005816 RNA-binding motif; other site 655817005817 YebO-like protein; Region: YebO; pfam13974 655817005818 YobH-like protein; Region: YobH; pfam13996 655817005819 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 655817005820 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655817005821 dimerization interface [polypeptide binding]; other site 655817005822 putative Zn2+ binding site [ion binding]; other site 655817005823 putative DNA binding site [nucleotide binding]; other site 655817005824 Bacterial transcriptional regulator; Region: IclR; pfam01614 655817005825 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817005826 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655817005827 putative substrate translocation pore; other site 655817005828 Predicted integral membrane protein [Function unknown]; Region: COG5521 655817005829 heat shock protein HtpX; Provisional; Region: PRK05457 655817005830 carboxy-terminal protease; Provisional; Region: PRK11186 655817005831 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 655817005832 protein binding site [polypeptide binding]; other site 655817005833 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 655817005834 Catalytic dyad [active] 655817005835 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 655817005836 ProP expression regulator; Provisional; Region: PRK04950 655817005837 ProQ/FINO family; Region: ProQ; pfam04352 655817005838 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 655817005839 GAF domain; Region: GAF_2; pfam13185 655817005840 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 655817005841 Paraquat-inducible protein A; Region: PqiA; pfam04403 655817005842 Paraquat-inducible protein A; Region: PqiA; pfam04403 655817005843 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 655817005844 mce related protein; Region: MCE; pfam02470 655817005845 mce related protein; Region: MCE; pfam02470 655817005846 mce related protein; Region: MCE; pfam02470 655817005847 mce related protein; Region: MCE; pfam02470 655817005848 mce related protein; Region: MCE; pfam02470 655817005849 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 655817005850 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817005851 S-adenosylmethionine binding site [chemical binding]; other site 655817005852 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 655817005853 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 655817005854 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 655817005855 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 655817005856 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 655817005857 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 655817005858 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 655817005859 hypothetical protein; Provisional; Region: PRK10301 655817005860 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 655817005861 Predicted amidohydrolase [General function prediction only]; Region: COG0388 655817005862 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 655817005863 exodeoxyribonuclease X; Provisional; Region: PRK07983 655817005864 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 655817005865 active site 655817005866 catalytic site [active] 655817005867 substrate binding site [chemical binding]; other site 655817005868 protease 2; Provisional; Region: PRK10115 655817005869 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 655817005870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 655817005871 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 655817005872 putative metal binding site [ion binding]; other site 655817005873 hypothetical protein; Provisional; Region: PRK13680 655817005874 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 655817005875 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 655817005876 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655817005877 ATP-grasp domain; Region: ATP-grasp; pfam02222 655817005878 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 655817005879 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 655817005880 active site 655817005881 intersubunit interface [polypeptide binding]; other site 655817005882 catalytic residue [active] 655817005883 phosphogluconate dehydratase; Validated; Region: PRK09054 655817005884 6-phosphogluconate dehydratase; Region: edd; TIGR01196 655817005885 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 655817005886 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 655817005887 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 655817005888 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 655817005889 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 655817005890 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 655817005891 putative active site [active] 655817005892 pyruvate kinase; Provisional; Region: PRK05826 655817005893 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 655817005894 domain interfaces; other site 655817005895 active site 655817005896 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 655817005897 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 655817005898 putative acyl-acceptor binding pocket; other site 655817005899 putative peptidase; Provisional; Region: PRK11649 655817005900 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 655817005901 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655817005902 Peptidase family M23; Region: Peptidase_M23; pfam01551 655817005903 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 655817005904 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 655817005905 metal binding site [ion binding]; metal-binding site 655817005906 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 655817005907 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 655817005908 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 655817005909 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817005910 ABC-ATPase subunit interface; other site 655817005911 dimer interface [polypeptide binding]; other site 655817005912 putative PBP binding regions; other site 655817005913 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 655817005914 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817005915 Walker A motif; other site 655817005916 ATP binding site [chemical binding]; other site 655817005917 Walker B motif; other site 655817005918 arginine finger; other site 655817005919 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 655817005920 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 655817005921 RuvA N terminal domain; Region: RuvA_N; pfam01330 655817005922 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 655817005923 hypothetical protein; Provisional; Region: PRK11470 655817005924 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 655817005925 active site 655817005926 putative DNA-binding cleft [nucleotide binding]; other site 655817005927 dimer interface [polypeptide binding]; other site 655817005928 hypothetical protein; Validated; Region: PRK00110 655817005929 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 655817005930 nudix motif; other site 655817005931 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 655817005932 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 655817005933 dimer interface [polypeptide binding]; other site 655817005934 anticodon binding site; other site 655817005935 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 655817005936 homodimer interface [polypeptide binding]; other site 655817005937 motif 1; other site 655817005938 active site 655817005939 motif 2; other site 655817005940 GAD domain; Region: GAD; pfam02938 655817005941 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 655817005942 motif 3; other site 655817005943 Isochorismatase family; Region: Isochorismatase; pfam00857 655817005944 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 655817005945 catalytic triad [active] 655817005946 conserved cis-peptide bond; other site 655817005947 hypothetical protein; Provisional; Region: PRK10302 655817005948 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 655817005949 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817005950 S-adenosylmethionine binding site [chemical binding]; other site 655817005951 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817005952 S-adenosylmethionine binding site [chemical binding]; other site 655817005953 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 655817005954 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 655817005955 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 655817005956 molybdopterin cofactor binding site [chemical binding]; other site 655817005957 substrate binding site [chemical binding]; other site 655817005958 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 655817005959 molybdopterin cofactor binding site; other site 655817005960 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 655817005961 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 655817005962 copper homeostasis protein CutC; Provisional; Region: PRK11572 655817005963 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 655817005964 putative metal binding site [ion binding]; other site 655817005965 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 655817005966 arginyl-tRNA synthetase; Region: argS; TIGR00456 655817005967 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 655817005968 active site 655817005969 HIGH motif; other site 655817005970 KMSK motif region; other site 655817005971 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 655817005972 tRNA binding surface [nucleotide binding]; other site 655817005973 anticodon binding site; other site 655817005974 Flagellar protein FlhE; Region: FlhE; pfam06366 655817005975 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 655817005976 FHIPEP family; Region: FHIPEP; pfam00771 655817005977 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 655817005978 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 655817005979 chemotaxis regulator CheZ; Provisional; Region: PRK11166 655817005980 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 655817005981 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817005982 active site 655817005983 phosphorylation site [posttranslational modification] 655817005984 intermolecular recognition site; other site 655817005985 dimerization interface [polypeptide binding]; other site 655817005986 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 655817005987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817005988 active site 655817005989 phosphorylation site [posttranslational modification] 655817005990 intermolecular recognition site; other site 655817005991 dimerization interface [polypeptide binding]; other site 655817005992 CheB methylesterase; Region: CheB_methylest; pfam01339 655817005993 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 655817005994 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 655817005995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817005996 S-adenosylmethionine binding site [chemical binding]; other site 655817005997 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 655817005998 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 655817005999 dimer interface [polypeptide binding]; other site 655817006000 ligand binding site [chemical binding]; other site 655817006001 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655817006002 dimerization interface [polypeptide binding]; other site 655817006003 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655817006004 dimer interface [polypeptide binding]; other site 655817006005 putative CheW interface [polypeptide binding]; other site 655817006006 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 655817006007 putative CheA interaction surface; other site 655817006008 chemotaxis protein CheA; Provisional; Region: PRK10547 655817006009 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 655817006010 putative binding surface; other site 655817006011 active site 655817006012 CheY binding; Region: CheY-binding; pfam09078 655817006013 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 655817006014 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817006015 ATP binding site [chemical binding]; other site 655817006016 Mg2+ binding site [ion binding]; other site 655817006017 G-X-G motif; other site 655817006018 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 655817006019 flagellar motor protein MotB; Validated; Region: motB; PRK09041 655817006020 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 655817006021 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 655817006022 ligand binding site [chemical binding]; other site 655817006023 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 655817006024 flagellar motor protein MotA; Validated; Region: PRK09110 655817006025 transcriptional activator FlhC; Provisional; Region: PRK12722 655817006026 transcriptional activator FlhD; Provisional; Region: PRK02909 655817006027 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 655817006028 Ligand Binding Site [chemical binding]; other site 655817006029 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 655817006030 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 655817006031 active site 655817006032 homotetramer interface [polypeptide binding]; other site 655817006033 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 655817006034 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 655817006035 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 655817006036 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 655817006037 TM-ABC transporter signature motif; other site 655817006038 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 655817006039 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 655817006040 Walker A/P-loop; other site 655817006041 ATP binding site [chemical binding]; other site 655817006042 Q-loop/lid; other site 655817006043 ABC transporter signature motif; other site 655817006044 Walker B; other site 655817006045 D-loop; other site 655817006046 H-loop/switch region; other site 655817006047 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 655817006048 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 655817006049 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 655817006050 ligand binding site [chemical binding]; other site 655817006051 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 655817006052 Ferritin-like domain; Region: Ferritin; pfam00210 655817006053 ferroxidase diiron center [ion binding]; other site 655817006054 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 655817006055 YecR-like lipoprotein; Region: YecR; pfam13992 655817006056 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 655817006057 Ferritin-like domain; Region: Ferritin; pfam00210 655817006058 ferroxidase diiron center [ion binding]; other site 655817006059 probable metal-binding protein; Region: matur_matur; TIGR03853 655817006060 tyrosine transporter TyrP; Provisional; Region: PRK15132 655817006061 aromatic amino acid transport protein; Region: araaP; TIGR00837 655817006062 hypothetical protein; Provisional; Region: PRK10396 655817006063 yecA family protein; Region: ygfB_yecA; TIGR02292 655817006064 SEC-C motif; Region: SEC-C; pfam02810 655817006065 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 655817006066 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 655817006067 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 655817006068 GIY-YIG motif/motif A; other site 655817006069 active site 655817006070 catalytic site [active] 655817006071 putative DNA binding site [nucleotide binding]; other site 655817006072 metal binding site [ion binding]; metal-binding site 655817006073 UvrB/uvrC motif; Region: UVR; pfam02151 655817006074 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 655817006075 Helix-hairpin-helix motif; Region: HHH; pfam00633 655817006076 response regulator; Provisional; Region: PRK09483 655817006077 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817006078 active site 655817006079 phosphorylation site [posttranslational modification] 655817006080 intermolecular recognition site; other site 655817006081 dimerization interface [polypeptide binding]; other site 655817006082 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817006083 DNA binding residues [nucleotide binding] 655817006084 dimerization interface [polypeptide binding]; other site 655817006085 hypothetical protein; Provisional; Region: PRK10613 655817006086 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 655817006087 Autoinducer binding domain; Region: Autoind_bind; pfam03472 655817006088 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817006089 DNA binding residues [nucleotide binding] 655817006090 dimerization interface [polypeptide binding]; other site 655817006091 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 655817006092 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 655817006093 Walker A/P-loop; other site 655817006094 ATP binding site [chemical binding]; other site 655817006095 Q-loop/lid; other site 655817006096 ABC transporter signature motif; other site 655817006097 Walker B; other site 655817006098 D-loop; other site 655817006099 H-loop/switch region; other site 655817006100 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 655817006101 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817006102 dimer interface [polypeptide binding]; other site 655817006103 conserved gate region; other site 655817006104 putative PBP binding loops; other site 655817006105 ABC-ATPase subunit interface; other site 655817006106 D-cysteine desulfhydrase; Validated; Region: PRK03910 655817006107 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 655817006108 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817006109 catalytic residue [active] 655817006110 cystine transporter subunit; Provisional; Region: PRK11260 655817006111 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817006112 substrate binding pocket [chemical binding]; other site 655817006113 membrane-bound complex binding site; other site 655817006114 hinge residues; other site 655817006115 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 655817006116 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 655817006117 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655817006118 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 655817006119 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655817006120 DNA binding residues [nucleotide binding] 655817006121 flagellin; Validated; Region: PRK08026 655817006122 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 655817006123 Flagellin protein; Region: FliC; pfam12445 655817006124 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 655817006125 flagellar capping protein; Reviewed; Region: fliD; PRK08032 655817006126 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 655817006127 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 655817006128 Flagellar protein FliS; Region: FliS; cl00654 655817006129 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 655817006130 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 655817006131 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 655817006132 active site 655817006133 Na/Ca binding site [ion binding]; other site 655817006134 catalytic site [active] 655817006135 lipoprotein; Provisional; Region: PRK10397 655817006136 putative inner membrane protein; Provisional; Region: PRK11099 655817006137 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 655817006138 CPxP motif; other site 655817006139 hypothetical protein; Provisional; Region: PRK09951 655817006140 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 655817006141 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 655817006142 trimer interface [polypeptide binding]; other site 655817006143 eyelet of channel; other site 655817006144 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655817006145 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 655817006146 substrate binding site [chemical binding]; other site 655817006147 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 655817006148 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 655817006149 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 655817006150 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 655817006151 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 655817006152 flagellar motor switch protein FliG; Region: fliG; TIGR00207 655817006153 FliG C-terminal domain; Region: FliG_C; pfam01706 655817006154 flagellar assembly protein H; Validated; Region: fliH; PRK05687 655817006155 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 655817006156 Flagellar assembly protein FliH; Region: FliH; pfam02108 655817006157 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 655817006158 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 655817006159 Walker A motif/ATP binding site; other site 655817006160 Walker B motif; other site 655817006161 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 655817006162 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 655817006163 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 655817006164 flagellar hook-length control protein; Provisional; Region: PRK10118 655817006165 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 655817006166 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 655817006167 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 655817006168 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 655817006169 flagellar motor switch protein; Validated; Region: fliN; PRK05698 655817006170 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 655817006171 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 655817006172 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 655817006173 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 655817006174 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 655817006175 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817006176 DNA binding residues [nucleotide binding] 655817006177 dimerization interface [polypeptide binding]; other site 655817006178 hypothetical protein; Provisional; Region: PRK10708 655817006179 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 655817006180 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 655817006181 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817006182 active site 655817006183 motif I; other site 655817006184 motif II; other site 655817006185 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 655817006186 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817006187 metal binding site [ion binding]; metal-binding site 655817006188 active site 655817006189 I-site; other site 655817006190 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 655817006191 hypothetical protein; Provisional; Region: PRK10062 655817006192 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 655817006193 EamA-like transporter family; Region: EamA; pfam00892 655817006194 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 655817006195 additional DNA contacts [nucleotide binding]; other site 655817006196 mismatch recognition site; other site 655817006197 active site 655817006198 zinc binding site [ion binding]; other site 655817006199 DNA intercalation site [nucleotide binding]; other site 655817006200 DNA cytosine methylase; Provisional; Region: PRK10458 655817006201 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 655817006202 cofactor binding site; other site 655817006203 DNA binding site [nucleotide binding] 655817006204 substrate interaction site [chemical binding]; other site 655817006205 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 655817006206 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655817006207 Zn2+ binding site [ion binding]; other site 655817006208 Mg2+ binding site [ion binding]; other site 655817006209 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 655817006210 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 655817006211 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 655817006212 trimer interface [polypeptide binding]; other site 655817006213 eyelet of channel; other site 655817006214 chaperone protein HchA; Provisional; Region: PRK04155 655817006215 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 655817006216 dimer interface [polypeptide binding]; other site 655817006217 metal binding site [ion binding]; metal-binding site 655817006218 potential oxyanion hole; other site 655817006219 potential catalytic triad [active] 655817006220 conserved cys residue [active] 655817006221 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 655817006222 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817006223 dimer interface [polypeptide binding]; other site 655817006224 phosphorylation site [posttranslational modification] 655817006225 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817006226 ATP binding site [chemical binding]; other site 655817006227 Mg2+ binding site [ion binding]; other site 655817006228 G-X-G motif; other site 655817006229 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 655817006230 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817006231 active site 655817006232 phosphorylation site [posttranslational modification] 655817006233 intermolecular recognition site; other site 655817006234 dimerization interface [polypeptide binding]; other site 655817006235 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817006236 DNA binding site [nucleotide binding] 655817006237 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 655817006238 active site 655817006239 homotetramer interface [polypeptide binding]; other site 655817006240 TMAO/DMSO reductase; Reviewed; Region: PRK05363 655817006241 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 655817006242 Moco binding site; other site 655817006243 metal coordination site [ion binding]; other site 655817006244 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 655817006245 zinc/cadmium-binding protein; Provisional; Region: PRK10306 655817006246 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 655817006247 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 655817006248 active site 655817006249 Int/Topo IB signature motif; other site 655817006250 salicylate synthase Irp9; Reviewed; Region: PRK06772 655817006251 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 655817006252 muropeptide transporter; Validated; Region: ampG; cl17669 655817006253 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655817006254 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817006255 Walker A/P-loop; other site 655817006256 ATP binding site [chemical binding]; other site 655817006257 Q-loop/lid; other site 655817006258 ABC transporter signature motif; other site 655817006259 Walker B; other site 655817006260 D-loop; other site 655817006261 H-loop/switch region; other site 655817006262 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655817006263 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 655817006264 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817006265 Walker A/P-loop; other site 655817006266 ATP binding site [chemical binding]; other site 655817006267 Q-loop/lid; other site 655817006268 ABC transporter signature motif; other site 655817006269 Walker B; other site 655817006270 D-loop; other site 655817006271 H-loop/switch region; other site 655817006272 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655817006273 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817006274 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 655817006275 Condensation domain; Region: Condensation; pfam00668 655817006276 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655817006277 Nonribosomal peptide synthase; Region: NRPS; pfam08415 655817006278 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 655817006279 acyl-activating enzyme (AAE) consensus motif; other site 655817006280 AMP binding site [chemical binding]; other site 655817006281 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817006282 S-adenosylmethionine binding site [chemical binding]; other site 655817006283 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 655817006284 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817006285 Condensation domain; Region: Condensation; pfam00668 655817006286 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655817006287 Nonribosomal peptide synthase; Region: NRPS; pfam08415 655817006288 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817006289 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655817006290 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655817006291 active site 655817006292 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655817006293 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 655817006294 Methyltransferase domain; Region: Methyltransf_12; pfam08242 655817006295 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 655817006296 KR domain; Region: KR; pfam08659 655817006297 NADP binding site [chemical binding]; other site 655817006298 active site 655817006299 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817006300 Condensation domain; Region: Condensation; pfam00668 655817006301 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655817006302 Nonribosomal peptide synthase; Region: NRPS; pfam08415 655817006303 Methyltransferase domain; Region: Methyltransf_12; pfam08242 655817006304 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817006305 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 655817006306 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 655817006307 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655817006308 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 655817006309 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 655817006310 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 655817006311 acyl-activating enzyme (AAE) consensus motif; other site 655817006312 active site 655817006313 AMP binding site [chemical binding]; other site 655817006314 substrate binding site [chemical binding]; other site 655817006315 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 655817006316 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817006317 N-terminal plug; other site 655817006318 ligand-binding site [chemical binding]; other site 655817006319 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 655817006320 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 655817006321 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 655817006322 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 655817006323 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 655817006324 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 655817006325 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 655817006326 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 655817006327 shikimate transporter; Provisional; Region: PRK09952 655817006328 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817006329 putative substrate translocation pore; other site 655817006330 AMP nucleosidase; Provisional; Region: PRK08292 655817006331 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 655817006332 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 655817006333 hypothetical protein; Provisional; Region: PRK12378 655817006334 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 655817006335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817006336 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 655817006337 putative dimerization interface [polypeptide binding]; other site 655817006338 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 655817006339 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817006340 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 655817006341 putative substrate binding site [chemical binding]; other site 655817006342 dimerization interface [polypeptide binding]; other site 655817006343 MATE family multidrug exporter; Provisional; Region: PRK10189 655817006344 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 655817006345 integrase; Provisional; Region: PRK09692 655817006346 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 655817006347 active site 655817006348 Int/Topo IB signature motif; other site 655817006349 Protein of unknown function (DUF1706); Region: DUF1706; pfam08020 655817006350 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 655817006351 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 655817006352 Beta-lactamase; Region: Beta-lactamase; pfam00144 655817006353 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655817006354 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655817006355 active site 655817006356 Condensation domain; Region: Condensation; pfam00668 655817006357 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655817006358 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 655817006359 acyl-activating enzyme (AAE) consensus motif; other site 655817006360 AMP binding site [chemical binding]; other site 655817006361 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817006362 Condensation domain; Region: Condensation; pfam00668 655817006363 non-ribosomal peptide synthase domain TIGR01720; Region: NRPS-para261 655817006364 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_6; cd13146 655817006365 Na+-driven multidrug efflux pump [Defense mechanisms]; Region: NorM; COG0534 655817006366 amidase; Provisional; Region: PRK06170 655817006367 Amidase; Region: Amidase; cl11426 655817006368 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655817006369 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655817006370 active site 655817006371 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817006372 Condensation domain; Region: Condensation; pfam00668 655817006373 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655817006374 Nonribosomal peptide synthase; Region: NRPS; pfam08415 655817006375 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 655817006376 acyl-activating enzyme (AAE) consensus motif; other site 655817006377 AMP binding site [chemical binding]; other site 655817006378 This family is the oxydase domain of NRPS (non-ribosomal peptide synthetase) and other proteins that modify polypeptides by cyclizing a thioester to form a ring. These include epoB, part of the epothilone biosynthesis pathway; tubD, part of the tubulysin...; Region: mcbC-like_oxidoreductase; cd02142 655817006379 putative FMN binding site [chemical binding]; other site 655817006380 NADPH bind site [chemical binding]; other site 655817006381 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 655817006382 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817006383 Condensation domain; Region: Condensation; pfam00668 655817006384 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655817006385 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655817006386 The adenylation domain of nonribosomal peptide synthetases (NRPS), including salinosporamide A polyketide synthase; Region: A_NRPS_Ta1_like; cd12116 655817006387 acyl-activating enzyme (AAE) consensus motif; other site 655817006388 AMP binding site [chemical binding]; other site 655817006389 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817006390 Condensation domain; Region: Condensation; pfam00668 655817006391 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655817006392 Nonribosomal peptide synthase; Region: NRPS; pfam08415 655817006393 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 655817006394 acyl-activating enzyme (AAE) consensus motif; other site 655817006395 AMP binding site [chemical binding]; other site 655817006396 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817006397 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655817006398 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655817006399 active site 655817006400 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 655817006401 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655817006402 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817006403 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655817006404 amino acid adenylation domain; Region: AA-adenyl-dom; TIGR01733 655817006405 acyl-activating enzyme (AAE) consensus motif; other site 655817006406 AMP binding site [chemical binding]; other site 655817006407 Condensation domain; Region: Condensation; pfam00668 655817006408 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655817006409 HxxPF-repeated domain; Region: HxxPF_rpt; pfam13745 655817006410 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 655817006411 acyl-activating enzyme (AAE) consensus motif; other site 655817006412 AMP binding site [chemical binding]; other site 655817006413 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817006414 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 655817006415 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655817006416 Acyl-CoA dehydrogenases [Lipid metabolism]; Region: CaiA; COG1960 655817006417 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 655817006418 active site 655817006419 acyl carrier protein; Provisional; Region: PRK07081 655817006420 3-hydroxyacyl-CoA dehydrogenase [Lipid metabolism]; Region: FadB; COG1250 655817006421 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 655817006422 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 655817006423 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655817006424 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655817006425 active site 655817006426 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817006427 Condensation domain; Region: Condensation; pfam00668 655817006428 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 655817006429 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Bacillus subtilis termination module Surfactin (SrfA-C); Region: A_NRPS_Srf_like; cd12117 655817006430 acyl-activating enzyme (AAE) consensus motif; other site 655817006431 AMP binding site [chemical binding]; other site 655817006432 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817006433 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 655817006434 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 655817006435 active site 655817006436 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 655817006437 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 655817006438 ketoreductase (KR), subgroup 2, complex (x) SDRs; Region: KR_2_SDR_x; cd08953 655817006439 KR domain; Region: KR; pfam08659 655817006440 putative NADP binding site [chemical binding]; other site 655817006441 active site 655817006442 Dehydratase domain in polyketide synthase (PKS) enzymes; Region: PKS_DH; smart00826 655817006443 enoyl reductase of polyketide synthase; Region: enoyl_red; cd05195 655817006444 Enoylreductase; Region: PKS_ER; smart00829 655817006445 NAD(P) binding site [chemical binding]; other site 655817006446 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817006447 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 655817006448 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 655817006449 DNA-binding interface [nucleotide binding]; DNA binding site 655817006450 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 655817006451 Integrase core domain; Region: rve; pfam00665 655817006452 Integrase core domain; Region: rve_3; pfam13683 655817006453 Integrase core domain; Region: rve_2; pfam13333 655817006454 L,D-transpeptidase; Provisional; Region: PRK10190 655817006455 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 655817006456 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 655817006457 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 655817006458 putative dimer interface [polypeptide binding]; other site 655817006459 active site pocket [active] 655817006460 putative cataytic base [active] 655817006461 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 655817006462 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 655817006463 homotrimer interface [polypeptide binding]; other site 655817006464 Walker A motif; other site 655817006465 GTP binding site [chemical binding]; other site 655817006466 Walker B motif; other site 655817006467 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 655817006468 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817006469 N-terminal plug; other site 655817006470 ligand-binding site [chemical binding]; other site 655817006471 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 655817006472 ParB-like nuclease domain; Region: ParBc; cl02129 655817006473 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 655817006474 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 655817006475 Active Sites [active] 655817006476 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 655817006477 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 655817006478 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 655817006479 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 655817006480 DXD motif; other site 655817006481 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 655817006482 putative trimer interface [polypeptide binding]; other site 655817006483 putative CoA binding site [chemical binding]; other site 655817006484 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 655817006485 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655817006486 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 655817006487 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655817006488 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 655817006489 substrate binding site [chemical binding]; other site 655817006490 dimer interface [polypeptide binding]; other site 655817006491 ATP binding site [chemical binding]; other site 655817006492 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 655817006493 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 655817006494 Protein of unknown function, DUF606; Region: DUF606; pfam04657 655817006495 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 655817006496 active site 655817006497 substrate binding pocket [chemical binding]; other site 655817006498 homodimer interaction site [polypeptide binding]; other site 655817006499 Gamma-glutamyltransferase [Amino acid transport and metabolism]; Region: Ggt; cl08040 655817006500 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 655817006501 Transposase; Region: DDE_Tnp_ISL3; pfam01610 655817006502 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 655817006503 Transposase; Region: DDE_Tnp_ISL3; pfam01610 655817006504 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 655817006505 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 655817006506 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 655817006507 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 655817006508 Haemolysin expression modulating protein; Region: HHA; cl11501 655817006509 Transposase; Region: DEDD_Tnp_IS110; pfam01548 655817006510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 655817006511 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 655817006512 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 655817006513 transposase/IS protein; Provisional; Region: PRK09183 655817006514 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817006515 Walker A motif; other site 655817006516 ATP binding site [chemical binding]; other site 655817006517 Walker B motif; other site 655817006518 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 655817006519 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 655817006520 DNA-binding interface [nucleotide binding]; DNA binding site 655817006521 Integrase core domain; Region: rve; pfam00665 655817006522 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 655817006523 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655817006524 Walker A/P-loop; other site 655817006525 ATP binding site [chemical binding]; other site 655817006526 Q-loop/lid; other site 655817006527 ABC transporter signature motif; other site 655817006528 Walker B; other site 655817006529 D-loop; other site 655817006530 H-loop/switch region; other site 655817006531 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817006532 dimer interface [polypeptide binding]; other site 655817006533 putative PBP binding regions; other site 655817006534 ABC-ATPase subunit interface; other site 655817006535 Periplasmic binding protein TroA_e. These proteins are predicted to function as initial receptors in the ABC metal ion uptake in eubacteria and archaea. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a...; Region: TroA_e; cd01142 655817006536 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 655817006537 putative ligand binding residues [chemical binding]; other site 655817006538 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 655817006539 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817006540 N-terminal plug; other site 655817006541 ligand-binding site [chemical binding]; other site 655817006542 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 655817006543 G1 box; other site 655817006544 GTP/Mg2+ binding site [chemical binding]; other site 655817006545 G2 box; other site 655817006546 Switch I region; other site 655817006547 Switch II region; other site 655817006548 hypothetical protein; Provisional; Region: PRK09866 655817006549 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 655817006550 G1 box; other site 655817006551 GTP/Mg2+ binding site [chemical binding]; other site 655817006552 G2 box; other site 655817006553 Switch I region; other site 655817006554 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 655817006555 G3 box; other site 655817006556 Switch II region; other site 655817006557 GTP/Mg2+ binding site [chemical binding]; other site 655817006558 G4 box; other site 655817006559 G5 box; other site 655817006560 YjcZ-like protein; Region: YjcZ; pfam13990 655817006561 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 655817006562 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 655817006563 nucleophile elbow; other site 655817006564 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 655817006565 Domain of unknown function (DUF932); Region: DUF932; pfam06067 655817006566 Antirestriction protein; Region: Antirestrict; pfam03230 655817006567 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 655817006568 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 655817006569 MPN+ (JAMM) motif; other site 655817006570 Zinc-binding site [ion binding]; other site 655817006571 Protein of unknown function (DUF987); Region: DUF987; pfam06174 655817006572 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 655817006573 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 655817006574 hypothetical protein; Provisional; Region: PRK05423 655817006575 Predicted membrane protein [Function unknown]; Region: COG1289 655817006576 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 655817006577 DNA gyrase inhibitor; Provisional; Region: PRK10016 655817006578 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 655817006579 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 655817006580 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 655817006581 exonuclease I; Provisional; Region: sbcB; PRK11779 655817006582 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 655817006583 active site 655817006584 catalytic site [active] 655817006585 substrate binding site [chemical binding]; other site 655817006586 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 655817006587 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 655817006588 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817006589 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 655817006590 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655817006591 dimerization interface [polypeptide binding]; other site 655817006592 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 655817006593 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 655817006594 putative NAD(P) binding site [chemical binding]; other site 655817006595 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 655817006596 antitoxin YefM; Provisional; Region: PRK11409 655817006597 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 655817006598 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 655817006599 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 655817006600 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 655817006601 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 655817006602 NAD binding site [chemical binding]; other site 655817006603 dimerization interface [polypeptide binding]; other site 655817006604 product binding site; other site 655817006605 substrate binding site [chemical binding]; other site 655817006606 zinc binding site [ion binding]; other site 655817006607 catalytic residues [active] 655817006608 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 655817006609 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655817006610 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817006611 homodimer interface [polypeptide binding]; other site 655817006612 catalytic residue [active] 655817006613 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 655817006614 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817006615 active site 655817006616 motif I; other site 655817006617 motif II; other site 655817006618 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 655817006619 putative active site pocket [active] 655817006620 4-fold oligomerization interface [polypeptide binding]; other site 655817006621 metal binding residues [ion binding]; metal-binding site 655817006622 3-fold/trimer interface [polypeptide binding]; other site 655817006623 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 655817006624 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 655817006625 putative active site [active] 655817006626 oxyanion strand; other site 655817006627 catalytic triad [active] 655817006628 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 655817006629 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 655817006630 catalytic residues [active] 655817006631 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 655817006632 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 655817006633 substrate binding site [chemical binding]; other site 655817006634 glutamase interaction surface [polypeptide binding]; other site 655817006635 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 655817006636 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 655817006637 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 655817006638 metal binding site [ion binding]; metal-binding site 655817006639 chain length determinant protein WzzB; Provisional; Region: PRK15471 655817006640 Chain length determinant protein; Region: Wzz; pfam02706 655817006641 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 655817006642 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 655817006643 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 655817006644 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 655817006645 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 655817006646 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 655817006647 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 655817006648 cupin fold metalloprotein, WbuC family; Region: cupin_WbuC; TIGR04366 655817006649 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655817006650 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 655817006651 UDP-N-acetylglucosamine 2-epimerase [Cell envelope biogenesis, outer membrane]; Region: WecB; COG0381 655817006652 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 655817006653 active site 655817006654 homodimer interface [polypeptide binding]; other site 655817006655 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 655817006656 capsular polysaccharide assembling protein (CAPF) like, extended (e) SDRs; Region: CAPF_like_SDR_e; cd05261 655817006657 putative NAD(P) binding site [chemical binding]; other site 655817006658 active site 655817006659 putative substrate binding site [chemical binding]; other site 655817006660 dTDP-4-dehydrorhamnose 3,5-epimerase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfbC; COG1898 655817006661 UDP-Glcnac (UDP-linked N-acetylglucosamine) inverting 4,6-dehydratase, extended (e) SDRs; Region: UDP_invert_4-6DH_SDR_e; cd05237 655817006662 homodimer interface [polypeptide binding]; other site 655817006663 NAD(P) binding site [chemical binding]; other site 655817006664 substrate binding site [chemical binding]; other site 655817006665 active site 655817006666 Polysaccharide biosynthesis protein C-terminal; Region: Polysacc_syn_2C; pfam08485 655817006667 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655817006668 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655817006669 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 655817006670 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 655817006671 trimer interface [polypeptide binding]; other site 655817006672 CoA binding site [chemical binding]; other site 655817006673 active site 655817006674 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655817006675 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 655817006676 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 655817006677 Subfamily of Glycosyltransferase Family GT2 of unknown function; Region: GT_2_like_c; cd04186 655817006678 Probable Catalytic site; other site 655817006679 metal-binding site 655817006680 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 655817006681 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 655817006682 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 655817006683 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 655817006684 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 655817006685 substrate binding site; other site 655817006686 tetramer interface; other site 655817006687 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 655817006688 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 655817006689 NADP binding site [chemical binding]; other site 655817006690 active site 655817006691 putative substrate binding site [chemical binding]; other site 655817006692 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 655817006693 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 655817006694 NAD binding site [chemical binding]; other site 655817006695 substrate binding site [chemical binding]; other site 655817006696 homodimer interface [polypeptide binding]; other site 655817006697 active site 655817006698 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 655817006699 active site 655817006700 tetramer interface; other site 655817006701 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 655817006702 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 655817006703 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 655817006704 putative ADP-binding pocket [chemical binding]; other site 655817006705 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 655817006706 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 655817006707 colanic acid exporter; Provisional; Region: PRK10459 655817006708 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 655817006709 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 655817006710 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 655817006711 phosphomannomutase CpsG; Provisional; Region: PRK15414 655817006712 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 655817006713 active site 655817006714 substrate binding site [chemical binding]; other site 655817006715 metal binding site [ion binding]; metal-binding site 655817006716 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 655817006717 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 655817006718 Substrate binding site; other site 655817006719 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 655817006720 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 655817006721 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 655817006722 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 655817006723 active site 655817006724 GDP-Mannose binding site [chemical binding]; other site 655817006725 dimer interface [polypeptide binding]; other site 655817006726 modified nudix motif 655817006727 metal binding site [ion binding]; metal-binding site 655817006728 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 655817006729 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 655817006730 NADP binding site [chemical binding]; other site 655817006731 active site 655817006732 putative substrate binding site [chemical binding]; other site 655817006733 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 655817006734 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 655817006735 NADP-binding site; other site 655817006736 homotetramer interface [polypeptide binding]; other site 655817006737 substrate binding site [chemical binding]; other site 655817006738 homodimer interface [polypeptide binding]; other site 655817006739 active site 655817006740 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 655817006741 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 655817006742 putative trimer interface [polypeptide binding]; other site 655817006743 putative active site [active] 655817006744 putative substrate binding site [chemical binding]; other site 655817006745 putative CoA binding site [chemical binding]; other site 655817006746 putative glycosyl transferase; Provisional; Region: PRK10063 655817006747 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 655817006748 metal-binding site 655817006749 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 655817006750 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 655817006751 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 655817006752 putative acyl transferase; Provisional; Region: PRK10191 655817006753 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 655817006754 trimer interface [polypeptide binding]; other site 655817006755 active site 655817006756 substrate binding site [chemical binding]; other site 655817006757 CoA binding site [chemical binding]; other site 655817006758 putative glycosyl transferase; Provisional; Region: PRK10018 655817006759 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 655817006760 active site 655817006761 tyrosine kinase; Provisional; Region: PRK11519 655817006762 Chain length determinant protein; Region: Wzz; pfam02706 655817006763 Chain length determinant protein; Region: Wzz; cl15801 655817006764 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 655817006765 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 655817006766 Low molecular weight phosphatase family; Region: LMWPc; cd00115 655817006767 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 655817006768 active site 655817006769 polysaccharide export protein Wza; Provisional; Region: PRK15078 655817006770 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 655817006771 SLBB domain; Region: SLBB; pfam10531 655817006772 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 655817006773 FOG: CBS domain [General function prediction only]; Region: COG0517 655817006774 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 655817006775 Transporter associated domain; Region: CorC_HlyC; smart01091 655817006776 Phage derived protein Gp49-like (DUF891); Region: Gp49; cl01470 655817006777 Uncharacterized conserved small protein [Function unknown]; Region: COG5606 655817006778 putative assembly protein; Provisional; Region: PRK10833 655817006779 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 655817006780 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 655817006781 trimer interface [polypeptide binding]; other site 655817006782 active site 655817006783 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 655817006784 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 655817006785 ATP-binding site [chemical binding]; other site 655817006786 Sugar specificity; other site 655817006787 Pyrimidine base specificity; other site 655817006788 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 655817006789 putative diguanylate cyclase; Provisional; Region: PRK09776 655817006790 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655817006791 putative active site [active] 655817006792 heme pocket [chemical binding]; other site 655817006793 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655817006794 putative active site [active] 655817006795 heme pocket [chemical binding]; other site 655817006796 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655817006797 putative active site [active] 655817006798 heme pocket [chemical binding]; other site 655817006799 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817006800 metal binding site [ion binding]; metal-binding site 655817006801 active site 655817006802 I-site; other site 655817006803 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 655817006804 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 655817006805 AlkA N-terminal domain; Region: AlkA_N; smart01009 655817006806 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 655817006807 minor groove reading motif; other site 655817006808 helix-hairpin-helix signature motif; other site 655817006809 substrate binding pocket [chemical binding]; other site 655817006810 active site 655817006811 putative chaperone; Provisional; Region: PRK11678 655817006812 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 655817006813 nucleotide binding site [chemical binding]; other site 655817006814 putative NEF/HSP70 interaction site [polypeptide binding]; other site 655817006815 SBD interface [polypeptide binding]; other site 655817006816 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 655817006817 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 655817006818 substrate binding site [chemical binding]; other site 655817006819 activation loop (A-loop); other site 655817006820 Y-family of DNA polymerases; Region: PolY; cl12025 655817006821 Protein phosphatase 2C; Region: PP2C_2; pfam13672 655817006822 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 655817006823 metal ion-dependent adhesion site (MIDAS); other site 655817006824 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 655817006825 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817006826 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817006827 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 655817006828 Protein export membrane protein; Region: SecD_SecF; cl14618 655817006829 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 655817006830 putative transporter; Provisional; Region: PRK10504 655817006831 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817006832 putative substrate translocation pore; other site 655817006833 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817006834 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 655817006835 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655817006836 dimerization interface [polypeptide binding]; other site 655817006837 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817006838 dimer interface [polypeptide binding]; other site 655817006839 phosphorylation site [posttranslational modification] 655817006840 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817006841 ATP binding site [chemical binding]; other site 655817006842 Mg2+ binding site [ion binding]; other site 655817006843 G-X-G motif; other site 655817006844 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 655817006845 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817006846 active site 655817006847 phosphorylation site [posttranslational modification] 655817006848 intermolecular recognition site; other site 655817006849 dimerization interface [polypeptide binding]; other site 655817006850 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817006851 DNA binding site [nucleotide binding] 655817006852 Uncharacterized conserved protein [Function unknown]; Region: COG3422 655817006853 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 655817006854 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 655817006855 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 655817006856 putative protease; Provisional; Region: PRK15452 655817006857 Peptidase family U32; Region: Peptidase_U32; pfam01136 655817006858 lipid kinase; Reviewed; Region: PRK13054 655817006859 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 655817006860 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655817006861 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 655817006862 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817006863 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 655817006864 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 655817006865 putative NAD(P) binding site [chemical binding]; other site 655817006866 catalytic Zn binding site [ion binding]; other site 655817006867 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 655817006868 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 655817006869 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 655817006870 active site 655817006871 P-loop; other site 655817006872 phosphorylation site [posttranslational modification] 655817006873 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655817006874 active site 655817006875 phosphorylation site [posttranslational modification] 655817006876 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 655817006877 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 655817006878 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 655817006879 intersubunit interface [polypeptide binding]; other site 655817006880 active site 655817006881 zinc binding site [ion binding]; other site 655817006882 Na+ binding site [ion binding]; other site 655817006883 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 655817006884 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 655817006885 putative active site; other site 655817006886 catalytic residue [active] 655817006887 nucleoside transporter; Region: 2A0110; TIGR00889 655817006888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817006889 putative substrate translocation pore; other site 655817006890 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 655817006891 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655817006892 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 655817006893 substrate binding site [chemical binding]; other site 655817006894 ATP binding site [chemical binding]; other site 655817006895 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 655817006896 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817006897 DNA-binding site [nucleotide binding]; DNA binding site 655817006898 UTRA domain; Region: UTRA; pfam07702 655817006899 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 655817006900 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 655817006901 active site 655817006902 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 655817006903 dimer interface [polypeptide binding]; other site 655817006904 substrate binding site [chemical binding]; other site 655817006905 ATP binding site [chemical binding]; other site 655817006906 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 655817006907 substrate binding site [chemical binding]; other site 655817006908 multimerization interface [polypeptide binding]; other site 655817006909 ATP binding site [chemical binding]; other site 655817006910 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 655817006911 putative metal binding site [ion binding]; other site 655817006912 putative homodimer interface [polypeptide binding]; other site 655817006913 putative homotetramer interface [polypeptide binding]; other site 655817006914 putative homodimer-homodimer interface [polypeptide binding]; other site 655817006915 putative allosteric switch controlling residues; other site 655817006916 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 655817006917 Predicted integral membrane protein [Function unknown]; Region: COG5455 655817006918 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 655817006919 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 655817006920 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 655817006921 PapC N-terminal domain; Region: PapC_N; pfam13954 655817006922 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 655817006923 PapC C-terminal domain; Region: PapC_C; pfam13953 655817006924 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 655817006925 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 655817006926 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 655817006927 Fimbrial protein; Region: Fimbrial; cl01416 655817006928 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 655817006929 antiporter inner membrane protein; Provisional; Region: PRK11670 655817006930 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 655817006931 Walker A motif; other site 655817006932 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 655817006933 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 655817006934 active site 655817006935 HIGH motif; other site 655817006936 KMSKS motif; other site 655817006937 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 655817006938 tRNA binding surface [nucleotide binding]; other site 655817006939 anticodon binding site; other site 655817006940 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 655817006941 dimer interface [polypeptide binding]; other site 655817006942 putative tRNA-binding site [nucleotide binding]; other site 655817006943 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 655817006944 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 655817006945 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 655817006946 MoxR-like ATPases [General function prediction only]; Region: COG0714 655817006947 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817006948 Walker A motif; other site 655817006949 ATP binding site [chemical binding]; other site 655817006950 Walker B motif; other site 655817006951 arginine finger; other site 655817006952 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 655817006953 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 655817006954 metal ion-dependent adhesion site (MIDAS); other site 655817006955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 655817006956 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 655817006957 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 655817006958 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 655817006959 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 655817006960 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817006961 active site 655817006962 phosphorylation site [posttranslational modification] 655817006963 intermolecular recognition site; other site 655817006964 dimerization interface [polypeptide binding]; other site 655817006965 LytTr DNA-binding domain; Region: LytTR; pfam04397 655817006966 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 655817006967 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 655817006968 GAF domain; Region: GAF; pfam01590 655817006969 Histidine kinase; Region: His_kinase; pfam06580 655817006970 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817006971 ATP binding site [chemical binding]; other site 655817006972 Mg2+ binding site [ion binding]; other site 655817006973 G-X-G motif; other site 655817006974 transcriptional regulator MirA; Provisional; Region: PRK15043 655817006975 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 655817006976 DNA binding residues [nucleotide binding] 655817006977 hypothetical protein; Provisional; Region: PRK13681 655817006978 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 655817006979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817006980 dimer interface [polypeptide binding]; other site 655817006981 conserved gate region; other site 655817006982 putative PBP binding loops; other site 655817006983 ABC-ATPase subunit interface; other site 655817006984 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 655817006985 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 655817006986 Walker A/P-loop; other site 655817006987 ATP binding site [chemical binding]; other site 655817006988 Q-loop/lid; other site 655817006989 ABC transporter signature motif; other site 655817006990 Walker B; other site 655817006991 D-loop; other site 655817006992 H-loop/switch region; other site 655817006993 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 655817006994 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817006995 dimer interface [polypeptide binding]; other site 655817006996 conserved gate region; other site 655817006997 ABC-ATPase subunit interface; other site 655817006998 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 655817006999 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 655817007000 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 655817007001 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 655817007002 D-lactate dehydrogenase; Provisional; Region: PRK11183 655817007003 FAD binding domain; Region: FAD_binding_4; pfam01565 655817007004 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 655817007005 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 655817007006 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 655817007007 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 655817007008 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 655817007009 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 655817007010 oxidoreductase; Provisional; Region: PRK12743 655817007011 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655817007012 NAD(P) binding site [chemical binding]; other site 655817007013 active site 655817007014 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 655817007015 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 655817007016 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 655817007017 FMN binding site [chemical binding]; other site 655817007018 active site 655817007019 catalytic residues [active] 655817007020 substrate binding site [chemical binding]; other site 655817007021 hypothetical protein; Provisional; Region: PRK01821 655817007022 hypothetical protein; Provisional; Region: PRK10711 655817007023 cytidine deaminase; Provisional; Region: PRK09027 655817007024 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 655817007025 active site 655817007026 catalytic motif [active] 655817007027 Zn binding site [ion binding]; other site 655817007028 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 655817007029 active site 655817007030 catalytic motif [active] 655817007031 Zn binding site [ion binding]; other site 655817007032 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 655817007033 putative active site [active] 655817007034 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 655817007035 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 655817007036 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 655817007037 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817007038 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 655817007039 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 655817007040 homodimer interface [polypeptide binding]; other site 655817007041 active site 655817007042 FMN binding site [chemical binding]; other site 655817007043 substrate binding site [chemical binding]; other site 655817007044 4Fe-4S binding domain; Region: Fer4; pfam00037 655817007045 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 655817007046 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 655817007047 TM-ABC transporter signature motif; other site 655817007048 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 655817007049 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 655817007050 Walker A/P-loop; other site 655817007051 ATP binding site [chemical binding]; other site 655817007052 Q-loop/lid; other site 655817007053 ABC transporter signature motif; other site 655817007054 Walker B; other site 655817007055 D-loop; other site 655817007056 H-loop/switch region; other site 655817007057 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 655817007058 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 655817007059 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 655817007060 ligand binding site [chemical binding]; other site 655817007061 calcium binding site [ion binding]; other site 655817007062 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 655817007063 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817007064 DNA binding site [nucleotide binding] 655817007065 domain linker motif; other site 655817007066 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 655817007067 dimerization interface (closed form) [polypeptide binding]; other site 655817007068 ligand binding site [chemical binding]; other site 655817007069 Predicted membrane protein [Function unknown]; Region: COG2311 655817007070 hypothetical protein; Provisional; Region: PRK10835 655817007071 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 655817007072 homodecamer interface [polypeptide binding]; other site 655817007073 GTP cyclohydrolase I; Provisional; Region: PLN03044 655817007074 active site 655817007075 putative catalytic site residues [active] 655817007076 zinc binding site [ion binding]; other site 655817007077 GTP-CH-I/GFRP interaction surface; other site 655817007078 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 655817007079 S-formylglutathione hydrolase; Region: PLN02442 655817007080 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 655817007081 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817007082 N-terminal plug; other site 655817007083 ligand-binding site [chemical binding]; other site 655817007084 lysine transporter; Provisional; Region: PRK10836 655817007085 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 655817007086 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817007087 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 655817007088 putative dimerization interface [polypeptide binding]; other site 655817007089 conserved hypothetical integral membrane protein; Region: TIGR00698 655817007090 endonuclease IV; Provisional; Region: PRK01060 655817007091 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 655817007092 AP (apurinic/apyrimidinic) site pocket; other site 655817007093 DNA interaction; other site 655817007094 Metal-binding active site; metal-binding site 655817007095 putative kinase; Provisional; Region: PRK09954 655817007096 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655817007097 putative DNA binding site [nucleotide binding]; other site 655817007098 putative Zn2+ binding site [ion binding]; other site 655817007099 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 655817007100 substrate binding site [chemical binding]; other site 655817007101 ATP binding site [chemical binding]; other site 655817007102 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 655817007103 active site 655817007104 tetramer interface [polypeptide binding]; other site 655817007105 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 655817007106 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 655817007107 ligand binding site [chemical binding]; other site 655817007108 flexible hinge region; other site 655817007109 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 655817007110 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 655817007111 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 655817007112 Nucleoside recognition; Region: Gate; pfam07670 655817007113 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 655817007114 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 655817007115 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 655817007116 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655817007117 substrate binding site [chemical binding]; other site 655817007118 ATP binding site [chemical binding]; other site 655817007119 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 655817007120 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 655817007121 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 655817007122 active site 655817007123 P-loop; other site 655817007124 phosphorylation site [posttranslational modification] 655817007125 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 655817007126 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 655817007127 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 655817007128 putative substrate binding site [chemical binding]; other site 655817007129 putative ATP binding site [chemical binding]; other site 655817007130 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 655817007131 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655817007132 active site 655817007133 phosphorylation site [posttranslational modification] 655817007134 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 655817007135 dimerization domain swap beta strand [polypeptide binding]; other site 655817007136 regulatory protein interface [polypeptide binding]; other site 655817007137 active site 655817007138 regulatory phosphorylation site [posttranslational modification]; other site 655817007139 sugar efflux transporter B; Provisional; Region: PRK15011 655817007140 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817007141 putative substrate translocation pore; other site 655817007142 Flagellin N-methylase; Region: FliB; pfam03692 655817007143 elongation factor P; Provisional; Region: PRK04542 655817007144 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 655817007145 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 655817007146 RNA binding site [nucleotide binding]; other site 655817007147 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 655817007148 RNA binding site [nucleotide binding]; other site 655817007149 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 655817007150 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 655817007151 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 655817007152 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 655817007153 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 655817007154 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 655817007155 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 655817007156 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 655817007157 active site 655817007158 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 655817007159 NlpC/P60 family; Region: NLPC_P60; pfam00877 655817007160 phage resistance protein; Provisional; Region: PRK10551 655817007161 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 655817007162 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817007163 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 655817007164 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 655817007165 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 655817007166 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817007167 dimer interface [polypeptide binding]; other site 655817007168 conserved gate region; other site 655817007169 putative PBP binding loops; other site 655817007170 ABC-ATPase subunit interface; other site 655817007171 microcin C ABC transporter permease; Provisional; Region: PRK15021 655817007172 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817007173 dimer interface [polypeptide binding]; other site 655817007174 conserved gate region; other site 655817007175 ABC-ATPase subunit interface; other site 655817007176 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 655817007177 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817007178 Walker A/P-loop; other site 655817007179 ATP binding site [chemical binding]; other site 655817007180 Q-loop/lid; other site 655817007181 ABC transporter signature motif; other site 655817007182 Walker B; other site 655817007183 D-loop; other site 655817007184 H-loop/switch region; other site 655817007185 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 655817007186 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817007187 Walker A/P-loop; other site 655817007188 ATP binding site [chemical binding]; other site 655817007189 Q-loop/lid; other site 655817007190 ABC transporter signature motif; other site 655817007191 Walker B; other site 655817007192 D-loop; other site 655817007193 H-loop/switch region; other site 655817007194 hypothetical protein; Provisional; Region: PRK11835 655817007195 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817007196 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 655817007197 putative substrate translocation pore; other site 655817007198 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 655817007199 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655817007200 RNA binding surface [nucleotide binding]; other site 655817007201 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 655817007202 active site 655817007203 uracil binding [chemical binding]; other site 655817007204 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 655817007205 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655817007206 ATP binding site [chemical binding]; other site 655817007207 putative Mg++ binding site [ion binding]; other site 655817007208 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817007209 nucleotide binding region [chemical binding]; other site 655817007210 ATP-binding site [chemical binding]; other site 655817007211 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 655817007212 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 655817007213 5S rRNA interface [nucleotide binding]; other site 655817007214 CTC domain interface [polypeptide binding]; other site 655817007215 L16 interface [polypeptide binding]; other site 655817007216 Nucleoid-associated protein [General function prediction only]; Region: COG3081 655817007217 nucleoid-associated protein NdpA; Validated; Region: PRK00378 655817007218 hypothetical protein; Provisional; Region: PRK13689 655817007219 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 655817007220 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 655817007221 Sulfatase; Region: Sulfatase; pfam00884 655817007222 transcriptional regulator NarP; Provisional; Region: PRK10403 655817007223 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817007224 active site 655817007225 phosphorylation site [posttranslational modification] 655817007226 intermolecular recognition site; other site 655817007227 dimerization interface [polypeptide binding]; other site 655817007228 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817007229 DNA binding residues [nucleotide binding] 655817007230 dimerization interface [polypeptide binding]; other site 655817007231 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 655817007232 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 655817007233 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 655817007234 binding surface 655817007235 TPR motif; other site 655817007236 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 655817007237 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 655817007238 catalytic residues [active] 655817007239 central insert; other site 655817007240 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 655817007241 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 655817007242 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 655817007243 heme exporter protein CcmC; Region: ccmC; TIGR01191 655817007244 heme exporter protein CcmB; Region: ccmB; TIGR01190 655817007245 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 655817007246 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 655817007247 Walker A/P-loop; other site 655817007248 ATP binding site [chemical binding]; other site 655817007249 Q-loop/lid; other site 655817007250 ABC transporter signature motif; other site 655817007251 Walker B; other site 655817007252 D-loop; other site 655817007253 H-loop/switch region; other site 655817007254 cytochrome c-type protein NapC; Provisional; Region: PRK10617 655817007255 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 655817007256 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 655817007257 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 655817007258 4Fe-4S binding domain; Region: Fer4_5; pfam12801 655817007259 4Fe-4S binding domain; Region: Fer4; cl02805 655817007260 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 655817007261 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 655817007262 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 655817007263 [4Fe-4S] binding site [ion binding]; other site 655817007264 molybdopterin cofactor binding site; other site 655817007265 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 655817007266 molybdopterin cofactor binding site; other site 655817007267 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 655817007268 ferredoxin-type protein; Provisional; Region: PRK10194 655817007269 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 655817007270 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 655817007271 secondary substrate binding site; other site 655817007272 primary substrate binding site; other site 655817007273 inhibition loop; other site 655817007274 dimerization interface [polypeptide binding]; other site 655817007275 malate:quinone oxidoreductase; Validated; Region: PRK05257 655817007276 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 655817007277 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 655817007278 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 655817007279 Walker A/P-loop; other site 655817007280 ATP binding site [chemical binding]; other site 655817007281 Q-loop/lid; other site 655817007282 ABC transporter signature motif; other site 655817007283 Walker B; other site 655817007284 D-loop; other site 655817007285 H-loop/switch region; other site 655817007286 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 655817007287 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 655817007288 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 655817007289 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817007290 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817007291 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 655817007292 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 655817007293 DNA binding site [nucleotide binding] 655817007294 active site 655817007295 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 655817007296 ApbE family; Region: ApbE; pfam02424 655817007297 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 655817007298 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 655817007299 trimer interface [polypeptide binding]; other site 655817007300 eyelet of channel; other site 655817007301 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 655817007302 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817007303 ATP binding site [chemical binding]; other site 655817007304 G-X-G motif; other site 655817007305 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 655817007306 putative binding surface; other site 655817007307 active site 655817007308 transcriptional regulator RcsB; Provisional; Region: PRK10840 655817007309 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817007310 active site 655817007311 phosphorylation site [posttranslational modification] 655817007312 intermolecular recognition site; other site 655817007313 dimerization interface [polypeptide binding]; other site 655817007314 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817007315 DNA binding residues [nucleotide binding] 655817007316 dimerization interface [polypeptide binding]; other site 655817007317 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 655817007318 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817007319 dimer interface [polypeptide binding]; other site 655817007320 phosphorylation site [posttranslational modification] 655817007321 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817007322 ATP binding site [chemical binding]; other site 655817007323 Mg2+ binding site [ion binding]; other site 655817007324 G-X-G motif; other site 655817007325 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 655817007326 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817007327 active site 655817007328 phosphorylation site [posttranslational modification] 655817007329 intermolecular recognition site; other site 655817007330 dimerization interface [polypeptide binding]; other site 655817007331 sensory histidine kinase AtoS; Provisional; Region: PRK11360 655817007332 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655817007333 putative active site [active] 655817007334 heme pocket [chemical binding]; other site 655817007335 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817007336 dimer interface [polypeptide binding]; other site 655817007337 phosphorylation site [posttranslational modification] 655817007338 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817007339 ATP binding site [chemical binding]; other site 655817007340 Mg2+ binding site [ion binding]; other site 655817007341 G-X-G motif; other site 655817007342 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 655817007343 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817007344 active site 655817007345 phosphorylation site [posttranslational modification] 655817007346 intermolecular recognition site; other site 655817007347 dimerization interface [polypeptide binding]; other site 655817007348 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817007349 Walker A motif; other site 655817007350 ATP binding site [chemical binding]; other site 655817007351 Walker B motif; other site 655817007352 arginine finger; other site 655817007353 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 655817007354 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 655817007355 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 655817007356 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 655817007357 putative acyltransferase; Provisional; Region: PRK05790 655817007358 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 655817007359 dimer interface [polypeptide binding]; other site 655817007360 active site 655817007361 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 655817007362 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 655817007363 Predicted secreted protein [Function unknown]; Region: COG5445 655817007364 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 655817007365 Predicted secreted protein [Function unknown]; Region: COG5445 655817007366 Stage II sporulation protein; Region: SpoIID; pfam08486 655817007367 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 655817007368 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 655817007369 MG2 domain; Region: A2M_N; pfam01835 655817007370 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 655817007371 Alpha-2-macroglobulin family; Region: A2M; pfam00207 655817007372 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 655817007373 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 655817007374 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 655817007375 DNA gyrase subunit A; Validated; Region: PRK05560 655817007376 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 655817007377 CAP-like domain; other site 655817007378 active site 655817007379 primary dimer interface [polypeptide binding]; other site 655817007380 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655817007381 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655817007382 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655817007383 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655817007384 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655817007385 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655817007386 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 655817007387 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817007388 S-adenosylmethionine binding site [chemical binding]; other site 655817007389 adhesin; Provisional; Region: PRK09752 655817007390 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 655817007391 Autotransporter beta-domain; Region: Autotransporter; pfam03797 655817007392 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 655817007393 ATP cone domain; Region: ATP-cone; pfam03477 655817007394 Class I ribonucleotide reductase; Region: RNR_I; cd01679 655817007395 active site 655817007396 dimer interface [polypeptide binding]; other site 655817007397 catalytic residues [active] 655817007398 effector binding site; other site 655817007399 R2 peptide binding site; other site 655817007400 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 655817007401 dimer interface [polypeptide binding]; other site 655817007402 putative radical transfer pathway; other site 655817007403 diiron center [ion binding]; other site 655817007404 tyrosyl radical; other site 655817007405 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 655817007406 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 655817007407 catalytic loop [active] 655817007408 iron binding site [ion binding]; other site 655817007409 hypothetical protein; Provisional; Region: PRK09902 655817007410 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 655817007411 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 655817007412 active site 655817007413 catalytic site [active] 655817007414 metal binding site [ion binding]; metal-binding site 655817007415 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 655817007416 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817007417 putative substrate translocation pore; other site 655817007418 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 655817007419 hydroxyglutarate oxidase; Provisional; Region: PRK11728 655817007420 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 655817007421 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 655817007422 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 655817007423 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 655817007424 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 655817007425 Cysteine-rich domain; Region: CCG; pfam02754 655817007426 Cysteine-rich domain; Region: CCG; pfam02754 655817007427 hypothetical protein; Provisional; Region: PRK09956 655817007428 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 655817007429 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 655817007430 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 655817007431 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817007432 putative substrate translocation pore; other site 655817007433 L-rhamnonate dehydratase; Provisional; Region: PRK15440 655817007434 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 655817007435 putative active site pocket [active] 655817007436 putative metal binding site [ion binding]; other site 655817007437 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 655817007438 Transcriptional regulator [Transcription]; Region: IclR; COG1414 655817007439 Bacterial transcriptional regulator; Region: IclR; pfam01614 655817007440 hypothetical protein; Provisional; Region: PRK03673 655817007441 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 655817007442 putative MPT binding site; other site 655817007443 Competence-damaged protein; Region: CinA; cl00666 655817007444 YfaZ precursor; Region: YfaZ; pfam07437 655817007445 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 655817007446 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 655817007447 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 655817007448 catalytic core [active] 655817007449 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 655817007450 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 655817007451 inhibitor-cofactor binding pocket; inhibition site 655817007452 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817007453 catalytic residue [active] 655817007454 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 655817007455 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 655817007456 Ligand binding site; other site 655817007457 Putative Catalytic site; other site 655817007458 DXD motif; other site 655817007459 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 655817007460 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 655817007461 substrate binding site [chemical binding]; other site 655817007462 cosubstrate binding site; other site 655817007463 catalytic site [active] 655817007464 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 655817007465 active site 655817007466 hexamer interface [polypeptide binding]; other site 655817007467 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 655817007468 NAD binding site [chemical binding]; other site 655817007469 substrate binding site [chemical binding]; other site 655817007470 active site 655817007471 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 655817007472 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 655817007473 putative active site [active] 655817007474 putative catalytic site [active] 655817007475 putative Zn binding site [ion binding]; other site 655817007476 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 655817007477 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 655817007478 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 655817007479 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 655817007480 signal transduction protein PmrD; Provisional; Region: PRK15450 655817007481 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 655817007482 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 655817007483 acyl-activating enzyme (AAE) consensus motif; other site 655817007484 putative AMP binding site [chemical binding]; other site 655817007485 putative active site [active] 655817007486 putative CoA binding site [chemical binding]; other site 655817007487 O-succinylbenzoate synthase; Provisional; Region: PRK05105 655817007488 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 655817007489 active site 655817007490 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655817007491 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 655817007492 substrate binding site [chemical binding]; other site 655817007493 oxyanion hole (OAH) forming residues; other site 655817007494 trimer interface [polypeptide binding]; other site 655817007495 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 655817007496 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 655817007497 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 655817007498 dimer interface [polypeptide binding]; other site 655817007499 tetramer interface [polypeptide binding]; other site 655817007500 PYR/PP interface [polypeptide binding]; other site 655817007501 TPP binding site [chemical binding]; other site 655817007502 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 655817007503 TPP-binding site; other site 655817007504 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 655817007505 isochorismate synthases; Region: isochor_syn; TIGR00543 655817007506 hypothetical protein; Provisional; Region: PRK10404 655817007507 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655817007508 Coenzyme A binding pocket [chemical binding]; other site 655817007509 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 655817007510 von Willebrand factor; Region: vWF_A; pfam12450 655817007511 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 655817007512 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 655817007513 metal ion-dependent adhesion site (MIDAS); other site 655817007514 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 655817007515 M28 Zn-Peptidases; Region: M28_like_1; cd05640 655817007516 Peptidase family M28; Region: Peptidase_M28; pfam04389 655817007517 metal binding site [ion binding]; metal-binding site 655817007518 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 655817007519 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 655817007520 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 655817007521 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 655817007522 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 655817007523 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 655817007524 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 655817007525 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 655817007526 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 655817007527 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 655817007528 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 655817007529 4Fe-4S binding domain; Region: Fer4; pfam00037 655817007530 4Fe-4S binding domain; Region: Fer4; pfam00037 655817007531 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 655817007532 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 655817007533 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 655817007534 catalytic loop [active] 655817007535 iron binding site [ion binding]; other site 655817007536 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 655817007537 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 655817007538 [4Fe-4S] binding site [ion binding]; other site 655817007539 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 655817007540 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 655817007541 SLBB domain; Region: SLBB; pfam10531 655817007542 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 655817007543 NADH dehydrogenase subunit E; Validated; Region: PRK07539 655817007544 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 655817007545 putative dimer interface [polypeptide binding]; other site 655817007546 [2Fe-2S] cluster binding site [ion binding]; other site 655817007547 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 655817007548 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 655817007549 NADH dehydrogenase subunit D; Validated; Region: PRK06075 655817007550 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 655817007551 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 655817007552 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 655817007553 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817007554 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 655817007555 putative dimerization interface [polypeptide binding]; other site 655817007556 aminotransferase AlaT; Validated; Region: PRK09265 655817007557 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655817007558 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817007559 homodimer interface [polypeptide binding]; other site 655817007560 catalytic residue [active] 655817007561 5'-nucleotidase; Provisional; Region: PRK03826 655817007562 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 655817007563 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 655817007564 TrkA-C domain; Region: TrkA_C; pfam02080 655817007565 TrkA-C domain; Region: TrkA_C; pfam02080 655817007566 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 655817007567 putative phosphatase; Provisional; Region: PRK11587 655817007568 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817007569 motif II; other site 655817007570 hypothetical protein; Validated; Region: PRK05445 655817007571 hypothetical protein; Provisional; Region: PRK01816 655817007572 propionate/acetate kinase; Provisional; Region: PRK12379 655817007573 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 655817007574 phosphate acetyltransferase; Reviewed; Region: PRK05632 655817007575 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 655817007576 DRTGG domain; Region: DRTGG; pfam07085 655817007577 phosphate acetyltransferase; Region: pta; TIGR00651 655817007578 hypothetical protein; Provisional; Region: PRK11588 655817007579 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 655817007580 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 655817007581 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 655817007582 nudix motif; other site 655817007583 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 655817007584 active site 655817007585 metal binding site [ion binding]; metal-binding site 655817007586 homotetramer interface [polypeptide binding]; other site 655817007587 glutathione S-transferase; Provisional; Region: PRK15113 655817007588 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 655817007589 C-terminal domain interface [polypeptide binding]; other site 655817007590 GSH binding site (G-site) [chemical binding]; other site 655817007591 dimer interface [polypeptide binding]; other site 655817007592 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 655817007593 N-terminal domain interface [polypeptide binding]; other site 655817007594 putative dimer interface [polypeptide binding]; other site 655817007595 putative substrate binding pocket (H-site) [chemical binding]; other site 655817007596 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 655817007597 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 655817007598 C-terminal domain interface [polypeptide binding]; other site 655817007599 GSH binding site (G-site) [chemical binding]; other site 655817007600 dimer interface [polypeptide binding]; other site 655817007601 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 655817007602 N-terminal domain interface [polypeptide binding]; other site 655817007603 putative dimer interface [polypeptide binding]; other site 655817007604 active site 655817007605 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 655817007606 homooctamer interface [polypeptide binding]; other site 655817007607 active site 655817007608 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 655817007609 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 655817007610 putative NAD(P) binding site [chemical binding]; other site 655817007611 putative active site [active] 655817007612 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 655817007613 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 655817007614 Walker A/P-loop; other site 655817007615 ATP binding site [chemical binding]; other site 655817007616 Q-loop/lid; other site 655817007617 ABC transporter signature motif; other site 655817007618 Walker B; other site 655817007619 D-loop; other site 655817007620 H-loop/switch region; other site 655817007621 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817007622 dimer interface [polypeptide binding]; other site 655817007623 conserved gate region; other site 655817007624 putative PBP binding loops; other site 655817007625 ABC-ATPase subunit interface; other site 655817007626 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 655817007627 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817007628 dimer interface [polypeptide binding]; other site 655817007629 conserved gate region; other site 655817007630 putative PBP binding loops; other site 655817007631 ABC-ATPase subunit interface; other site 655817007632 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 655817007633 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817007634 substrate binding pocket [chemical binding]; other site 655817007635 membrane-bound complex binding site; other site 655817007636 hinge residues; other site 655817007637 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 655817007638 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817007639 substrate binding pocket [chemical binding]; other site 655817007640 membrane-bound complex binding site; other site 655817007641 hinge residues; other site 655817007642 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 655817007643 Flavoprotein; Region: Flavoprotein; pfam02441 655817007644 amidophosphoribosyltransferase; Provisional; Region: PRK09246 655817007645 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 655817007646 active site 655817007647 tetramer interface [polypeptide binding]; other site 655817007648 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655817007649 active site 655817007650 colicin V production protein; Provisional; Region: PRK10845 655817007651 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 655817007652 cell division protein DedD; Provisional; Region: PRK11633 655817007653 Sporulation related domain; Region: SPOR; pfam05036 655817007654 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 655817007655 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655817007656 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655817007657 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 655817007658 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 655817007659 hypothetical protein; Provisional; Region: PRK10847 655817007660 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 655817007661 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 655817007662 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 655817007663 dimerization interface 3.5A [polypeptide binding]; other site 655817007664 active site 655817007665 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 655817007666 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 655817007667 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 655817007668 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 655817007669 ligand binding site [chemical binding]; other site 655817007670 NAD binding site [chemical binding]; other site 655817007671 catalytic site [active] 655817007672 homodimer interface [polypeptide binding]; other site 655817007673 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 655817007674 putative transporter; Provisional; Region: PRK12382 655817007675 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817007676 putative substrate translocation pore; other site 655817007677 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 655817007678 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 655817007679 dimer interface [polypeptide binding]; other site 655817007680 active site 655817007681 Uncharacterized conserved protein [Function unknown]; Region: COG4121 655817007682 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 655817007683 YfcL protein; Region: YfcL; pfam08891 655817007684 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 655817007685 hypothetical protein; Provisional; Region: PRK10621 655817007686 Predicted permeases [General function prediction only]; Region: COG0730 655817007687 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 655817007688 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 655817007689 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 655817007690 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 655817007691 Tetramer interface [polypeptide binding]; other site 655817007692 active site 655817007693 FMN-binding site [chemical binding]; other site 655817007694 HemK family putative methylases; Region: hemK_fam; TIGR00536 655817007695 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817007696 S-adenosylmethionine binding site [chemical binding]; other site 655817007697 hypothetical protein; Provisional; Region: PRK04946 655817007698 Smr domain; Region: Smr; pfam01713 655817007699 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 655817007700 Fimbrial protein; Region: Fimbrial; cl01416 655817007701 Fimbrial protein; Region: Fimbrial; cl01416 655817007702 Fimbrial protein; Region: Fimbrial; cl01416 655817007703 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 655817007704 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 655817007705 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 655817007706 PapC N-terminal domain; Region: PapC_N; pfam13954 655817007707 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 655817007708 PapC C-terminal domain; Region: PapC_C; pfam13953 655817007709 Fimbrial protein; Region: Fimbrial; cl01416 655817007710 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 655817007711 catalytic core [active] 655817007712 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 655817007713 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655817007714 substrate binding site [chemical binding]; other site 655817007715 oxyanion hole (OAH) forming residues; other site 655817007716 trimer interface [polypeptide binding]; other site 655817007717 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 655817007718 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 655817007719 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 655817007720 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 655817007721 dimer interface [polypeptide binding]; other site 655817007722 active site 655817007723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 655817007724 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 655817007725 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 655817007726 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 655817007727 Outer membrane protein (OmpH-like); Region: OmpH; pfam03938 655817007728 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 655817007729 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 655817007730 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 655817007731 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 655817007732 Autotransporter beta-domain; Region: Autotransporter; pfam03797 655817007733 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 655817007734 active site 655817007735 DNA binding site [nucleotide binding] 655817007736 Int/Topo IB signature motif; other site 655817007737 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 655817007738 active site 655817007739 DNA binding site [nucleotide binding] 655817007740 Int/Topo IB signature motif; other site 655817007741 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 655817007742 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817007743 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 655817007744 dimerization interface [polypeptide binding]; other site 655817007745 substrate binding pocket [chemical binding]; other site 655817007746 permease DsdX; Provisional; Region: PRK09921 655817007747 gluconate transporter; Region: gntP; TIGR00791 655817007748 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 655817007749 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 655817007750 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655817007751 catalytic residue [active] 655817007752 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 655817007753 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817007754 putative substrate translocation pore; other site 655817007755 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817007756 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 655817007757 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817007758 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817007759 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 655817007760 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817007761 active site 655817007762 phosphorylation site [posttranslational modification] 655817007763 intermolecular recognition site; other site 655817007764 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817007765 DNA binding residues [nucleotide binding] 655817007766 dimerization interface [polypeptide binding]; other site 655817007767 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 655817007768 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817007769 substrate binding pocket [chemical binding]; other site 655817007770 membrane-bound complex binding site; other site 655817007771 hinge residues; other site 655817007772 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817007773 substrate binding pocket [chemical binding]; other site 655817007774 membrane-bound complex binding site; other site 655817007775 hinge residues; other site 655817007776 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817007777 dimer interface [polypeptide binding]; other site 655817007778 phosphorylation site [posttranslational modification] 655817007779 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817007780 ATP binding site [chemical binding]; other site 655817007781 Mg2+ binding site [ion binding]; other site 655817007782 G-X-G motif; other site 655817007783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817007784 active site 655817007785 phosphorylation site [posttranslational modification] 655817007786 intermolecular recognition site; other site 655817007787 dimerization interface [polypeptide binding]; other site 655817007788 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 655817007789 putative binding surface; other site 655817007790 active site 655817007791 putative CoA-transferase; Provisional; Region: PRK11430 655817007792 CoA-transferase family III; Region: CoA_transf_3; pfam02515 655817007793 putative transporter YfdV; Provisional; Region: PRK09903 655817007794 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 655817007795 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 655817007796 PYR/PP interface [polypeptide binding]; other site 655817007797 dimer interface [polypeptide binding]; other site 655817007798 TPP binding site [chemical binding]; other site 655817007799 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 655817007800 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 655817007801 TPP-binding site; other site 655817007802 dimer interface [polypeptide binding]; other site 655817007803 formyl-coenzyme A transferase; Provisional; Region: PRK05398 655817007804 CoA-transferase family III; Region: CoA_transf_3; pfam02515 655817007805 hypothetical protein; Provisional; Region: PRK10316 655817007806 YfdX protein; Region: YfdX; pfam10938 655817007807 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 655817007808 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 655817007809 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 655817007810 putative acyl-acceptor binding pocket; other site 655817007811 aminotransferase; Validated; Region: PRK08175 655817007812 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655817007813 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817007814 homodimer interface [polypeptide binding]; other site 655817007815 catalytic residue [active] 655817007816 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 655817007817 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 655817007818 GAF domain; Region: GAF; cl17456 655817007819 Histidine kinase; Region: His_kinase; pfam06580 655817007820 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817007821 ATP binding site [chemical binding]; other site 655817007822 Mg2+ binding site [ion binding]; other site 655817007823 G-X-G motif; other site 655817007824 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 655817007825 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817007826 active site 655817007827 phosphorylation site [posttranslational modification] 655817007828 intermolecular recognition site; other site 655817007829 dimerization interface [polypeptide binding]; other site 655817007830 LytTr DNA-binding domain; Region: LytTR; pfam04397 655817007831 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655817007832 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817007833 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 655817007834 dimerization domain swap beta strand [polypeptide binding]; other site 655817007835 regulatory protein interface [polypeptide binding]; other site 655817007836 active site 655817007837 regulatory phosphorylation site [posttranslational modification]; other site 655817007838 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 655817007839 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 655817007840 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 655817007841 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 655817007842 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655817007843 active site 655817007844 phosphorylation site [posttranslational modification] 655817007845 exoaminopeptidase; Provisional; Region: PRK09961 655817007846 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 655817007847 oligomer interface [polypeptide binding]; other site 655817007848 active site 655817007849 metal binding site [ion binding]; metal-binding site 655817007850 aminopeptidase; Provisional; Region: PRK09795 655817007851 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 655817007852 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 655817007853 active site 655817007854 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 655817007855 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 655817007856 active site 655817007857 P-loop; other site 655817007858 phosphorylation site [posttranslational modification] 655817007859 glucokinase, proteobacterial type; Region: glk; TIGR00749 655817007860 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655817007861 nucleotide binding site [chemical binding]; other site 655817007862 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 655817007863 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 655817007864 Cl- selectivity filter; other site 655817007865 Cl- binding residues [ion binding]; other site 655817007866 pore gating glutamate residue; other site 655817007867 dimer interface [polypeptide binding]; other site 655817007868 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 655817007869 manganese transport protein MntH; Reviewed; Region: PRK00701 655817007870 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 655817007871 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 655817007872 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 655817007873 Nucleoside recognition; Region: Gate; pfam07670 655817007874 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 655817007875 MASE1; Region: MASE1; pfam05231 655817007876 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 655817007877 diguanylate cyclase; Region: GGDEF; smart00267 655817007878 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817007879 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 655817007880 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655817007881 salt bridge; other site 655817007882 non-specific DNA binding site [nucleotide binding]; other site 655817007883 sequence-specific DNA binding site [nucleotide binding]; other site 655817007884 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 655817007885 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 655817007886 active site 655817007887 HIGH motif; other site 655817007888 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 655817007889 active site 655817007890 KMSKS motif; other site 655817007891 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 655817007892 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817007893 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 655817007894 putative dimerization interface [polypeptide binding]; other site 655817007895 putative substrate binding pocket [chemical binding]; other site 655817007896 XapX domain; Region: XapX; TIGR03510 655817007897 nucleoside transporter; Region: 2A0110; TIGR00889 655817007898 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817007899 putative substrate translocation pore; other site 655817007900 purine nucleoside phosphorylase; Provisional; Region: PRK08202 655817007901 hypothetical protein; Provisional; Region: PRK11528 655817007902 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655817007903 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817007904 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 655817007905 putative dimerization interface [polypeptide binding]; other site 655817007906 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 655817007907 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 655817007908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 655817007909 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 655817007910 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 655817007911 nucleotide binding pocket [chemical binding]; other site 655817007912 K-X-D-G motif; other site 655817007913 catalytic site [active] 655817007914 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 655817007915 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 655817007916 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 655817007917 Dimer interface [polypeptide binding]; other site 655817007918 BRCT sequence motif; other site 655817007919 cell division protein ZipA; Provisional; Region: PRK03427 655817007920 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 655817007921 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 655817007922 FtsZ protein binding site [polypeptide binding]; other site 655817007923 putative sulfate transport protein CysZ; Validated; Region: PRK04949 655817007924 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 655817007925 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 655817007926 dimer interface [polypeptide binding]; other site 655817007927 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817007928 catalytic residue [active] 655817007929 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 655817007930 dimerization domain swap beta strand [polypeptide binding]; other site 655817007931 regulatory protein interface [polypeptide binding]; other site 655817007932 active site 655817007933 regulatory phosphorylation site [posttranslational modification]; other site 655817007934 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 655817007935 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 655817007936 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 655817007937 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 655817007938 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 655817007939 HPr interaction site; other site 655817007940 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655817007941 active site 655817007942 phosphorylation site [posttranslational modification] 655817007943 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 655817007944 dimer interface [polypeptide binding]; other site 655817007945 pyridoxamine kinase; Validated; Region: PRK05756 655817007946 pyridoxal binding site [chemical binding]; other site 655817007947 ATP binding site [chemical binding]; other site 655817007948 hypothetical protein; Provisional; Region: PRK10318 655817007949 cysteine synthase B; Region: cysM; TIGR01138 655817007950 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 655817007951 dimer interface [polypeptide binding]; other site 655817007952 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817007953 catalytic residue [active] 655817007954 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 655817007955 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 655817007956 Walker A/P-loop; other site 655817007957 ATP binding site [chemical binding]; other site 655817007958 Q-loop/lid; other site 655817007959 ABC transporter signature motif; other site 655817007960 Walker B; other site 655817007961 D-loop; other site 655817007962 H-loop/switch region; other site 655817007963 TOBE-like domain; Region: TOBE_3; pfam12857 655817007964 sulfate transport protein; Provisional; Region: cysT; CHL00187 655817007965 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817007966 dimer interface [polypeptide binding]; other site 655817007967 conserved gate region; other site 655817007968 putative PBP binding loops; other site 655817007969 ABC-ATPase subunit interface; other site 655817007970 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 655817007971 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817007972 dimer interface [polypeptide binding]; other site 655817007973 conserved gate region; other site 655817007974 putative PBP binding loops; other site 655817007975 ABC-ATPase subunit interface; other site 655817007976 thiosulfate transporter subunit; Provisional; Region: PRK10852 655817007977 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 655817007978 short chain dehydrogenase; Provisional; Region: PRK08226 655817007979 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 655817007980 NAD binding site [chemical binding]; other site 655817007981 homotetramer interface [polypeptide binding]; other site 655817007982 homodimer interface [polypeptide binding]; other site 655817007983 active site 655817007984 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 655817007985 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 655817007986 putative active site [active] 655817007987 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 655817007988 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655817007989 active site turn [active] 655817007990 phosphorylation site [posttranslational modification] 655817007991 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655817007992 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 655817007993 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 655817007994 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 655817007995 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 655817007996 putative acetyltransferase; Provisional; Region: PRK03624 655817007997 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655817007998 Coenzyme A binding pocket [chemical binding]; other site 655817007999 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 655817008000 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 655817008001 active site 655817008002 metal binding site [ion binding]; metal-binding site 655817008003 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 655817008004 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 655817008005 transcriptional regulator EutR; Provisional; Region: PRK10130 655817008006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817008007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817008008 carboxysome structural protein EutK; Provisional; Region: PRK15466 655817008009 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 655817008010 Hexamer interface [polypeptide binding]; other site 655817008011 Hexagonal pore residue; other site 655817008012 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 655817008013 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 655817008014 putative hexamer interface [polypeptide binding]; other site 655817008015 putative hexagonal pore; other site 655817008016 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 655817008017 putative hexamer interface [polypeptide binding]; other site 655817008018 putative hexagonal pore; other site 655817008019 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 655817008020 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 655817008021 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 655817008022 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 655817008023 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 655817008024 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 655817008025 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 655817008026 active site 655817008027 metal binding site [ion binding]; metal-binding site 655817008028 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 655817008029 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655817008030 nucleotide binding site [chemical binding]; other site 655817008031 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 655817008032 putative catalytic cysteine [active] 655817008033 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 655817008034 Hexamer/Pentamer interface [polypeptide binding]; other site 655817008035 central pore; other site 655817008036 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 655817008037 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 655817008038 Hexamer interface [polypeptide binding]; other site 655817008039 Putative hexagonal pore residue; other site 655817008040 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 655817008041 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 655817008042 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 655817008043 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 655817008044 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 655817008045 G1 box; other site 655817008046 GTP/Mg2+ binding site [chemical binding]; other site 655817008047 G2 box; other site 655817008048 Switch I region; other site 655817008049 G3 box; other site 655817008050 Switch II region; other site 655817008051 G4 box; other site 655817008052 G5 box; other site 655817008053 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 655817008054 putative hexamer interface [polypeptide binding]; other site 655817008055 putative hexagonal pore; other site 655817008056 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 655817008057 Malic enzyme, N-terminal domain; Region: malic; pfam00390 655817008058 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 655817008059 putative NAD(P) binding site [chemical binding]; other site 655817008060 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 655817008061 transaldolase-like protein; Provisional; Region: PTZ00411 655817008062 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 655817008063 active site 655817008064 dimer interface [polypeptide binding]; other site 655817008065 catalytic residue [active] 655817008066 transketolase; Reviewed; Region: PRK12753 655817008067 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 655817008068 TPP-binding site [chemical binding]; other site 655817008069 dimer interface [polypeptide binding]; other site 655817008070 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 655817008071 PYR/PP interface [polypeptide binding]; other site 655817008072 dimer interface [polypeptide binding]; other site 655817008073 TPP binding site [chemical binding]; other site 655817008074 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655817008075 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 655817008076 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 655817008077 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 655817008078 dimer interface [polypeptide binding]; other site 655817008079 ADP-ribose binding site [chemical binding]; other site 655817008080 active site 655817008081 nudix motif; other site 655817008082 metal binding site [ion binding]; metal-binding site 655817008083 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 655817008084 4Fe-4S binding domain; Region: Fer4; pfam00037 655817008085 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 655817008086 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817008087 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 655817008088 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 655817008089 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655817008090 dimerization interface [polypeptide binding]; other site 655817008091 Histidine kinase; Region: HisKA_3; pfam07730 655817008092 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817008093 ATP binding site [chemical binding]; other site 655817008094 Mg2+ binding site [ion binding]; other site 655817008095 G-X-G motif; other site 655817008096 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 655817008097 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 655817008098 Protein export membrane protein; Region: SecD_SecF; cl14618 655817008099 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 655817008100 ArsC family; Region: ArsC; pfam03960 655817008101 putative catalytic residues [active] 655817008102 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 655817008103 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 655817008104 metal binding site [ion binding]; metal-binding site 655817008105 dimer interface [polypeptide binding]; other site 655817008106 hypothetical protein; Provisional; Region: PRK13664 655817008107 putative hydrolase; Provisional; Region: PRK11460 655817008108 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 655817008109 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 655817008110 Helicase; Region: Helicase_RecD; pfam05127 655817008111 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 655817008112 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 655817008113 Predicted metalloprotease [General function prediction only]; Region: COG2321 655817008114 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 655817008115 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 655817008116 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 655817008117 ATP binding site [chemical binding]; other site 655817008118 active site 655817008119 substrate binding site [chemical binding]; other site 655817008120 lipoprotein; Provisional; Region: PRK11679 655817008121 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 655817008122 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 655817008123 dihydrodipicolinate synthase; Region: dapA; TIGR00674 655817008124 dimer interface [polypeptide binding]; other site 655817008125 active site 655817008126 catalytic residue [active] 655817008127 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 655817008128 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 655817008129 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 655817008130 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 655817008131 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 655817008132 catalytic triad [active] 655817008133 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 655817008134 Domain of unknown function DUF20; Region: UPF0118; pfam01594 655817008135 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 655817008136 Peptidase family M48; Region: Peptidase_M48; cl12018 655817008137 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 655817008138 ArsC family; Region: ArsC; pfam03960 655817008139 catalytic residues [active] 655817008140 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 655817008141 DNA replication initiation factor; Provisional; Region: PRK08084 655817008142 uracil transporter; Provisional; Region: PRK10720 655817008143 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655817008144 active site 655817008145 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 655817008146 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 655817008147 dimerization interface [polypeptide binding]; other site 655817008148 putative ATP binding site [chemical binding]; other site 655817008149 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 655817008150 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 655817008151 active site 655817008152 substrate binding site [chemical binding]; other site 655817008153 cosubstrate binding site; other site 655817008154 catalytic site [active] 655817008155 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 655817008156 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 655817008157 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 655817008158 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 655817008159 domain interface [polypeptide binding]; other site 655817008160 active site 655817008161 catalytic site [active] 655817008162 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 655817008163 putative active site [active] 655817008164 catalytic site [active] 655817008165 exopolyphosphatase; Provisional; Region: PRK10854 655817008166 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 655817008167 MASE1; Region: MASE1; pfam05231 655817008168 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 655817008169 diguanylate cyclase; Region: GGDEF; smart00267 655817008170 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817008171 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 655817008172 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 655817008173 GMP synthase; Reviewed; Region: guaA; PRK00074 655817008174 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 655817008175 AMP/PPi binding site [chemical binding]; other site 655817008176 candidate oxyanion hole; other site 655817008177 catalytic triad [active] 655817008178 potential glutamine specificity residues [chemical binding]; other site 655817008179 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 655817008180 ATP Binding subdomain [chemical binding]; other site 655817008181 Ligand Binding sites [chemical binding]; other site 655817008182 Dimerization subdomain; other site 655817008183 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 655817008184 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 655817008185 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 655817008186 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 655817008187 active site 655817008188 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 655817008189 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 655817008190 generic binding surface II; other site 655817008191 generic binding surface I; other site 655817008192 RatA-like protein; Provisional; Region: PRK15316 655817008193 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 655817008194 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 655817008195 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 655817008196 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 655817008197 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 655817008198 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 655817008199 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 655817008200 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 655817008201 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 655817008202 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 655817008203 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 655817008204 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 655817008205 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 655817008206 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 655817008207 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 655817008208 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 655817008209 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 655817008210 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 655817008211 intimin-like protein SinH; Provisional; Region: PRK15318 655817008212 intimin-like protein SinH; Provisional; Region: PRK15318 655817008213 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 655817008214 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 655817008215 GTP-binding protein Der; Reviewed; Region: PRK00093 655817008216 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 655817008217 G1 box; other site 655817008218 GTP/Mg2+ binding site [chemical binding]; other site 655817008219 Switch I region; other site 655817008220 G2 box; other site 655817008221 Switch II region; other site 655817008222 G3 box; other site 655817008223 G4 box; other site 655817008224 G5 box; other site 655817008225 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 655817008226 G1 box; other site 655817008227 GTP/Mg2+ binding site [chemical binding]; other site 655817008228 Switch I region; other site 655817008229 G2 box; other site 655817008230 G3 box; other site 655817008231 Switch II region; other site 655817008232 G4 box; other site 655817008233 G5 box; other site 655817008234 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 655817008235 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 655817008236 Trp docking motif [polypeptide binding]; other site 655817008237 active site 655817008238 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 655817008239 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 655817008240 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 655817008241 dimer interface [polypeptide binding]; other site 655817008242 motif 1; other site 655817008243 active site 655817008244 motif 2; other site 655817008245 motif 3; other site 655817008246 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 655817008247 anticodon binding site; other site 655817008248 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 655817008249 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 655817008250 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 655817008251 cytoskeletal protein RodZ; Provisional; Region: PRK10856 655817008252 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655817008253 non-specific DNA binding site [nucleotide binding]; other site 655817008254 salt bridge; other site 655817008255 sequence-specific DNA binding site [nucleotide binding]; other site 655817008256 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 655817008257 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 655817008258 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817008259 FeS/SAM binding site; other site 655817008260 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 655817008261 active site 655817008262 multimer interface [polypeptide binding]; other site 655817008263 penicillin-binding protein 1C; Provisional; Region: PRK11240 655817008264 Transglycosylase; Region: Transgly; pfam00912 655817008265 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 655817008266 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 655817008267 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 655817008268 MG2 domain; Region: A2M_N; pfam01835 655817008269 Alpha-2-macroglobulin family; Region: A2M; pfam00207 655817008270 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 655817008271 surface patch; other site 655817008272 thioester region; other site 655817008273 specificity defining residues; other site 655817008274 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 655817008275 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 655817008276 active site residue [active] 655817008277 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 655817008278 active site residue [active] 655817008279 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 655817008280 aminopeptidase B; Provisional; Region: PRK05015 655817008281 Peptidase; Region: DUF3663; pfam12404 655817008282 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 655817008283 interface (dimer of trimers) [polypeptide binding]; other site 655817008284 Substrate-binding/catalytic site; other site 655817008285 Zn-binding sites [ion binding]; other site 655817008286 hypothetical protein; Provisional; Region: PRK10721 655817008287 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 655817008288 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 655817008289 catalytic loop [active] 655817008290 iron binding site [ion binding]; other site 655817008291 chaperone protein HscA; Provisional; Region: hscA; PRK05183 655817008292 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 655817008293 nucleotide binding site [chemical binding]; other site 655817008294 putative NEF/HSP70 interaction site [polypeptide binding]; other site 655817008295 SBD interface [polypeptide binding]; other site 655817008296 co-chaperone HscB; Provisional; Region: hscB; PRK05014 655817008297 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 655817008298 HSP70 interaction site [polypeptide binding]; other site 655817008299 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 655817008300 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 655817008301 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 655817008302 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 655817008303 trimerization site [polypeptide binding]; other site 655817008304 active site 655817008305 cysteine desulfurase; Provisional; Region: PRK14012 655817008306 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 655817008307 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655817008308 catalytic residue [active] 655817008309 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 655817008310 Rrf2 family protein; Region: rrf2_super; TIGR00738 655817008311 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 655817008312 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 655817008313 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 655817008314 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 655817008315 active site 655817008316 dimerization interface [polypeptide binding]; other site 655817008317 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 655817008318 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 655817008319 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 655817008320 PRD domain; Region: PRD; pfam00874 655817008321 PRD domain; Region: PRD; pfam00874 655817008322 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 655817008323 MFS_1 like family; Region: MFS_1_like; pfam12832 655817008324 Predicted membrane protein [Function unknown]; Region: COG2259 655817008325 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 655817008326 active site 655817008327 catalytic residues [active] 655817008328 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655817008329 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 655817008330 putative NAD(P) binding site [chemical binding]; other site 655817008331 catalytic Zn binding site [ion binding]; other site 655817008332 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 655817008333 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 655817008334 TM-ABC transporter signature motif; other site 655817008335 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 655817008336 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 655817008337 Walker A/P-loop; other site 655817008338 ATP binding site [chemical binding]; other site 655817008339 Q-loop/lid; other site 655817008340 ABC transporter signature motif; other site 655817008341 Walker B; other site 655817008342 D-loop; other site 655817008343 H-loop/switch region; other site 655817008344 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 655817008345 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 655817008346 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 655817008347 ligand binding site [chemical binding]; other site 655817008348 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655817008349 TPR motif; other site 655817008350 binding surface 655817008351 TPR repeat; Region: TPR_11; pfam13414 655817008352 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655817008353 TPR motif; other site 655817008354 binding surface 655817008355 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 655817008356 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 655817008357 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655817008358 nucleotide binding site [chemical binding]; other site 655817008359 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 655817008360 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 655817008361 dimer interface [polypeptide binding]; other site 655817008362 active site 655817008363 glycine-pyridoxal phosphate binding site [chemical binding]; other site 655817008364 folate binding site [chemical binding]; other site 655817008365 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 655817008366 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 655817008367 heme-binding site [chemical binding]; other site 655817008368 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 655817008369 FAD binding pocket [chemical binding]; other site 655817008370 FAD binding motif [chemical binding]; other site 655817008371 phosphate binding motif [ion binding]; other site 655817008372 beta-alpha-beta structure motif; other site 655817008373 NAD binding pocket [chemical binding]; other site 655817008374 Heme binding pocket [chemical binding]; other site 655817008375 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 655817008376 Nitrogen regulatory protein P-II; Region: P-II; smart00938 655817008377 response regulator GlrR; Provisional; Region: PRK15115 655817008378 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817008379 active site 655817008380 phosphorylation site [posttranslational modification] 655817008381 intermolecular recognition site; other site 655817008382 dimerization interface [polypeptide binding]; other site 655817008383 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817008384 Walker A motif; other site 655817008385 ATP binding site [chemical binding]; other site 655817008386 Walker B motif; other site 655817008387 arginine finger; other site 655817008388 hypothetical protein; Provisional; Region: PRK10722 655817008389 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655817008390 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817008391 dimer interface [polypeptide binding]; other site 655817008392 phosphorylation site [posttranslational modification] 655817008393 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817008394 ATP binding site [chemical binding]; other site 655817008395 Mg2+ binding site [ion binding]; other site 655817008396 G-X-G motif; other site 655817008397 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 655817008398 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 655817008399 dimerization interface [polypeptide binding]; other site 655817008400 ATP binding site [chemical binding]; other site 655817008401 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 655817008402 dimerization interface [polypeptide binding]; other site 655817008403 ATP binding site [chemical binding]; other site 655817008404 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 655817008405 putative active site [active] 655817008406 catalytic triad [active] 655817008407 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 655817008408 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817008409 substrate binding pocket [chemical binding]; other site 655817008410 membrane-bound complex binding site; other site 655817008411 hinge residues; other site 655817008412 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 655817008413 N-acetyl-D-glucosamine binding site [chemical binding]; other site 655817008414 catalytic residue [active] 655817008415 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 655817008416 nucleoside/Zn binding site; other site 655817008417 dimer interface [polypeptide binding]; other site 655817008418 catalytic motif [active] 655817008419 hypothetical protein; Provisional; Region: PRK11590 655817008420 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 655817008421 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 655817008422 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 655817008423 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 655817008424 putative active site [active] 655817008425 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 655817008426 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 655817008427 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 655817008428 active site 655817008429 hydrophilic channel; other site 655817008430 dimerization interface [polypeptide binding]; other site 655817008431 catalytic residues [active] 655817008432 active site lid [active] 655817008433 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 655817008434 Recombination protein O N terminal; Region: RecO_N; pfam11967 655817008435 Recombination protein O C terminal; Region: RecO_C; pfam02565 655817008436 GTPase Era; Reviewed; Region: era; PRK00089 655817008437 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 655817008438 G1 box; other site 655817008439 GTP/Mg2+ binding site [chemical binding]; other site 655817008440 Switch I region; other site 655817008441 G2 box; other site 655817008442 Switch II region; other site 655817008443 G3 box; other site 655817008444 G4 box; other site 655817008445 G5 box; other site 655817008446 KH domain; Region: KH_2; pfam07650 655817008447 ribonuclease III; Reviewed; Region: rnc; PRK00102 655817008448 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 655817008449 dimerization interface [polypeptide binding]; other site 655817008450 active site 655817008451 metal binding site [ion binding]; metal-binding site 655817008452 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 655817008453 dsRNA binding site [nucleotide binding]; other site 655817008454 signal peptidase I; Provisional; Region: PRK10861 655817008455 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 655817008456 Catalytic site [active] 655817008457 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 655817008458 GTP-binding protein LepA; Provisional; Region: PRK05433 655817008459 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 655817008460 G1 box; other site 655817008461 putative GEF interaction site [polypeptide binding]; other site 655817008462 GTP/Mg2+ binding site [chemical binding]; other site 655817008463 Switch I region; other site 655817008464 G2 box; other site 655817008465 G3 box; other site 655817008466 Switch II region; other site 655817008467 G4 box; other site 655817008468 G5 box; other site 655817008469 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 655817008470 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 655817008471 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 655817008472 SoxR reducing system protein RseC; Provisional; Region: PRK10862 655817008473 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 655817008474 anti-sigma E factor; Provisional; Region: rseB; PRK09455 655817008475 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 655817008476 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 655817008477 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 655817008478 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 655817008479 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655817008480 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655817008481 DNA binding residues [nucleotide binding] 655817008482 L-aspartate oxidase; Provisional; Region: PRK09077 655817008483 L-aspartate oxidase; Provisional; Region: PRK06175 655817008484 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 655817008485 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 655817008486 Methyltransferase domain; Region: Methyltransf_26; pfam13659 655817008487 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 655817008488 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 655817008489 ATP binding site [chemical binding]; other site 655817008490 Mg++ binding site [ion binding]; other site 655817008491 motif III; other site 655817008492 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817008493 nucleotide binding region [chemical binding]; other site 655817008494 ATP-binding site [chemical binding]; other site 655817008495 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655817008496 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817008497 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 655817008498 dimerization interface [polypeptide binding]; other site 655817008499 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 655817008500 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 655817008501 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 655817008502 ligand binding site [chemical binding]; other site 655817008503 active site 655817008504 UGI interface [polypeptide binding]; other site 655817008505 catalytic site [active] 655817008506 putative methyltransferase; Provisional; Region: PRK10864 655817008507 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 655817008508 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 655817008509 thioredoxin 2; Provisional; Region: PRK10996 655817008510 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 655817008511 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 655817008512 catalytic residues [active] 655817008513 Uncharacterized conserved protein [Function unknown]; Region: COG3148 655817008514 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 655817008515 CoA binding domain; Region: CoA_binding_2; pfam13380 655817008516 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 655817008517 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 655817008518 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 655817008519 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 655817008520 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 655817008521 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 655817008522 domain interface [polypeptide binding]; other site 655817008523 putative active site [active] 655817008524 catalytic site [active] 655817008525 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 655817008526 domain interface [polypeptide binding]; other site 655817008527 putative active site [active] 655817008528 catalytic site [active] 655817008529 lipoprotein; Provisional; Region: PRK10759 655817008530 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 655817008531 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817008532 putative substrate translocation pore; other site 655817008533 protein disaggregation chaperone; Provisional; Region: PRK10865 655817008534 Clp amino terminal domain; Region: Clp_N; pfam02861 655817008535 Clp amino terminal domain; Region: Clp_N; pfam02861 655817008536 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817008537 Walker A motif; other site 655817008538 ATP binding site [chemical binding]; other site 655817008539 Walker B motif; other site 655817008540 arginine finger; other site 655817008541 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817008542 Walker A motif; other site 655817008543 ATP binding site [chemical binding]; other site 655817008544 Walker B motif; other site 655817008545 arginine finger; other site 655817008546 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 655817008547 hypothetical protein; Provisional; Region: PRK10723 655817008548 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 655817008549 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 655817008550 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655817008551 RNA binding surface [nucleotide binding]; other site 655817008552 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 655817008553 active site 655817008554 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 655817008555 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 655817008556 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 655817008557 30S subunit binding site; other site 655817008558 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 655817008559 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 655817008560 Prephenate dehydratase; Region: PDT; pfam00800 655817008561 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 655817008562 putative L-Phe binding site [chemical binding]; other site 655817008563 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 655817008564 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 655817008565 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 655817008566 prephenate dehydrogenase; Validated; Region: PRK08507 655817008567 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 655817008568 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 655817008569 lipoprotein; Provisional; Region: PRK11443 655817008570 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 655817008571 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 655817008572 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 655817008573 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817008574 metal binding site [ion binding]; metal-binding site 655817008575 active site 655817008576 I-site; other site 655817008577 putative outer membrane lipoprotein; Provisional; Region: PRK09967 655817008578 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 655817008579 ligand binding site [chemical binding]; other site 655817008580 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 655817008581 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 655817008582 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 655817008583 RimM N-terminal domain; Region: RimM; pfam01782 655817008584 PRC-barrel domain; Region: PRC; pfam05239 655817008585 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 655817008586 signal recognition particle protein; Provisional; Region: PRK10867 655817008587 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 655817008588 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 655817008589 P loop; other site 655817008590 GTP binding site [chemical binding]; other site 655817008591 Signal peptide binding domain; Region: SRP_SPB; pfam02978 655817008592 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 655817008593 hypothetical protein; Provisional; Region: PRK11573 655817008594 Domain of unknown function DUF21; Region: DUF21; pfam01595 655817008595 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 655817008596 Transporter associated domain; Region: CorC_HlyC; smart01091 655817008597 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 655817008598 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 655817008599 dimer interface [polypeptide binding]; other site 655817008600 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 655817008601 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 655817008602 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 655817008603 recombination and repair protein; Provisional; Region: PRK10869 655817008604 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 655817008605 Walker A/P-loop; other site 655817008606 ATP binding site [chemical binding]; other site 655817008607 Q-loop/lid; other site 655817008608 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 655817008609 Q-loop/lid; other site 655817008610 ABC transporter signature motif; other site 655817008611 Walker B; other site 655817008612 D-loop; other site 655817008613 H-loop/switch region; other site 655817008614 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 655817008615 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 655817008616 hypothetical protein; Validated; Region: PRK01777 655817008617 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 655817008618 putative coenzyme Q binding site [chemical binding]; other site 655817008619 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 655817008620 SmpB-tmRNA interface; other site 655817008621 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 655817008622 substrate binding pocket [chemical binding]; other site 655817008623 active site 655817008624 iron coordination sites [ion binding]; other site 655817008625 Predicted dehydrogenase [General function prediction only]; Region: COG0579 655817008626 hydroxyglutarate oxidase; Provisional; Region: PRK11728 655817008627 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 655817008628 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 655817008629 tetramerization interface [polypeptide binding]; other site 655817008630 NAD(P) binding site [chemical binding]; other site 655817008631 catalytic residues [active] 655817008632 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 655817008633 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655817008634 inhibitor-cofactor binding pocket; inhibition site 655817008635 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817008636 catalytic residue [active] 655817008637 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 655817008638 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 655817008639 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817008640 DNA-binding site [nucleotide binding]; DNA binding site 655817008641 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 655817008642 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 655817008643 bacterial OsmY and nodulation domain; Region: BON; smart00749 655817008644 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655817008645 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 655817008646 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655817008647 dimerization interface [polypeptide binding]; other site 655817008648 putative DNA binding site [nucleotide binding]; other site 655817008649 putative Zn2+ binding site [ion binding]; other site 655817008650 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 655817008651 active site residue [active] 655817008652 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 655817008653 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 655817008654 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 655817008655 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 655817008656 hypothetical protein; Provisional; Region: PRK10556 655817008657 hypothetical protein; Provisional; Region: PRK10132 655817008658 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 655817008659 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817008660 DNA-binding site [nucleotide binding]; DNA binding site 655817008661 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655817008662 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817008663 homodimer interface [polypeptide binding]; other site 655817008664 catalytic residue [active] 655817008665 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 655817008666 Uncharacterized conserved protein [Function unknown]; Region: COG2128 655817008667 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 655817008668 catalytic residues [active] 655817008669 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 655817008670 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 655817008671 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 655817008672 Class I ribonucleotide reductase; Region: RNR_I; cd01679 655817008673 active site 655817008674 dimer interface [polypeptide binding]; other site 655817008675 catalytic residues [active] 655817008676 effector binding site; other site 655817008677 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 655817008678 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 655817008679 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 655817008680 dimer interface [polypeptide binding]; other site 655817008681 putative radical transfer pathway; other site 655817008682 diiron center [ion binding]; other site 655817008683 tyrosyl radical; other site 655817008684 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 655817008685 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 655817008686 Walker A/P-loop; other site 655817008687 ATP binding site [chemical binding]; other site 655817008688 Q-loop/lid; other site 655817008689 ABC transporter signature motif; other site 655817008690 Walker B; other site 655817008691 D-loop; other site 655817008692 H-loop/switch region; other site 655817008693 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 655817008694 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 655817008695 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817008696 dimer interface [polypeptide binding]; other site 655817008697 conserved gate region; other site 655817008698 putative PBP binding loops; other site 655817008699 ABC-ATPase subunit interface; other site 655817008700 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 655817008701 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 655817008702 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 655817008703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817008704 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 655817008705 putative L-valine exporter; Provisional; Region: PRK10408 655817008706 transcriptional repressor MprA; Provisional; Region: PRK10870 655817008707 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655817008708 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 655817008709 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817008710 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817008711 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 655817008712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817008713 putative substrate translocation pore; other site 655817008714 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817008715 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655817008716 Zn2+ binding site [ion binding]; other site 655817008717 Mg2+ binding site [ion binding]; other site 655817008718 AAA domain; Region: AAA_33; pfam13671 655817008719 S-ribosylhomocysteinase; Provisional; Region: PRK02260 655817008720 glutamate--cysteine ligase; Provisional; Region: PRK02107 655817008721 Predicted membrane protein [Function unknown]; Region: COG1238 655817008722 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 655817008723 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817008724 motif II; other site 655817008725 carbon storage regulator; Provisional; Region: PRK01712 655817008726 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 655817008727 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 655817008728 motif 1; other site 655817008729 active site 655817008730 motif 2; other site 655817008731 motif 3; other site 655817008732 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 655817008733 DHHA1 domain; Region: DHHA1; pfam02272 655817008734 recombination regulator RecX; Reviewed; Region: recX; PRK00117 655817008735 recombinase A; Provisional; Region: recA; PRK09354 655817008736 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 655817008737 hexamer interface [polypeptide binding]; other site 655817008738 Walker A motif; other site 655817008739 ATP binding site [chemical binding]; other site 655817008740 Walker B motif; other site 655817008741 hypothetical protein; Validated; Region: PRK03661 655817008742 Transglycosylase SLT domain; Region: SLT_2; pfam13406 655817008743 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 655817008744 N-acetyl-D-glucosamine binding site [chemical binding]; other site 655817008745 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 655817008746 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 655817008747 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 655817008748 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 655817008749 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 655817008750 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 655817008751 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 655817008752 putative NAD(P) binding site [chemical binding]; other site 655817008753 active site 655817008754 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 655817008755 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 655817008756 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 655817008757 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817008758 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 655817008759 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 655817008760 putative active site [active] 655817008761 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 655817008762 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 655817008763 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 655817008764 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817008765 Walker A motif; other site 655817008766 ATP binding site [chemical binding]; other site 655817008767 Walker B motif; other site 655817008768 arginine finger; other site 655817008769 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 655817008770 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 655817008771 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 655817008772 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 655817008773 iron binding site [ion binding]; other site 655817008774 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 655817008775 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655817008776 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817008777 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 655817008778 Acylphosphatase; Region: Acylphosphatase; pfam00708 655817008779 HypF finger; Region: zf-HYPF; pfam07503 655817008780 HypF finger; Region: zf-HYPF; pfam07503 655817008781 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 655817008782 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 655817008783 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 655817008784 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655817008785 non-specific DNA binding site [nucleotide binding]; other site 655817008786 salt bridge; other site 655817008787 sequence-specific DNA binding site [nucleotide binding]; other site 655817008788 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 655817008789 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 655817008790 nickel binding site [ion binding]; other site 655817008791 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 655817008792 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 655817008793 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 655817008794 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 655817008795 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 655817008796 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 655817008797 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 655817008798 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 655817008799 NADH dehydrogenase; Region: NADHdh; cl00469 655817008800 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 655817008801 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 655817008802 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 655817008803 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 655817008804 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 655817008805 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 655817008806 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 655817008807 hydrogenase assembly chaperone; Provisional; Region: PRK10409 655817008808 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 655817008809 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 655817008810 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 655817008811 dimerization interface [polypeptide binding]; other site 655817008812 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 655817008813 ATP binding site [chemical binding]; other site 655817008814 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 655817008815 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 655817008816 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 655817008817 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817008818 Walker A motif; other site 655817008819 ATP binding site [chemical binding]; other site 655817008820 Walker B motif; other site 655817008821 arginine finger; other site 655817008822 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 655817008823 molybdenum-pterin binding domain; Region: Mop; TIGR00638 655817008824 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 655817008825 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 655817008826 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 655817008827 MutS domain I; Region: MutS_I; pfam01624 655817008828 MutS domain II; Region: MutS_II; pfam05188 655817008829 MutS domain III; Region: MutS_III; pfam05192 655817008830 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 655817008831 Walker A/P-loop; other site 655817008832 ATP binding site [chemical binding]; other site 655817008833 Q-loop/lid; other site 655817008834 ABC transporter signature motif; other site 655817008835 Walker B; other site 655817008836 D-loop; other site 655817008837 H-loop/switch region; other site 655817008838 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 655817008839 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 655817008840 active site 655817008841 metal binding site [ion binding]; metal-binding site 655817008842 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655817008843 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 655817008844 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817008845 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 655817008846 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 655817008847 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 655817008848 putative aldolase; Validated; Region: PRK08130 655817008849 active site 655817008850 intersubunit interface [polypeptide binding]; other site 655817008851 Zn2+ binding site [ion binding]; other site 655817008852 hypothetical protein; Provisional; Region: PRK09989 655817008853 putative transporter; Provisional; Region: PRK09821 655817008854 GntP family permease; Region: GntP_permease; pfam02447 655817008855 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 655817008856 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 655817008857 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 655817008858 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 655817008859 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 655817008860 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655817008861 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 655817008862 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655817008863 DNA binding residues [nucleotide binding] 655817008864 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 655817008865 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655817008866 Peptidase family M23; Region: Peptidase_M23; pfam01551 655817008867 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 655817008868 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817008869 S-adenosylmethionine binding site [chemical binding]; other site 655817008870 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 655817008871 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 655817008872 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 655817008873 Permutation of conserved domain; other site 655817008874 active site 655817008875 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 655817008876 homotrimer interaction site [polypeptide binding]; other site 655817008877 zinc binding site [ion binding]; other site 655817008878 CDP-binding sites; other site 655817008879 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 655817008880 substrate binding site; other site 655817008881 dimer interface; other site 655817008882 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 655817008883 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 655817008884 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 655817008885 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 655817008886 ligand-binding site [chemical binding]; other site 655817008887 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 655817008888 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 655817008889 CysD dimerization site [polypeptide binding]; other site 655817008890 G1 box; other site 655817008891 putative GEF interaction site [polypeptide binding]; other site 655817008892 GTP/Mg2+ binding site [chemical binding]; other site 655817008893 Switch I region; other site 655817008894 G2 box; other site 655817008895 G3 box; other site 655817008896 Switch II region; other site 655817008897 G4 box; other site 655817008898 G5 box; other site 655817008899 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 655817008900 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 655817008901 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 655817008902 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 655817008903 Active Sites [active] 655817008904 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 655817008905 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 655817008906 metal binding site [ion binding]; metal-binding site 655817008907 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 655817008908 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 655817008909 Active Sites [active] 655817008910 sulfite reductase subunit beta; Provisional; Region: PRK13504 655817008911 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 655817008912 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 655817008913 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 655817008914 Flavodoxin; Region: Flavodoxin_1; pfam00258 655817008915 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 655817008916 FAD binding pocket [chemical binding]; other site 655817008917 FAD binding motif [chemical binding]; other site 655817008918 catalytic residues [active] 655817008919 NAD binding pocket [chemical binding]; other site 655817008920 phosphate binding motif [ion binding]; other site 655817008921 beta-alpha-beta structure motif; other site 655817008922 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 655817008923 active site 655817008924 FAD dependent oxidoreductase; Region: DAO; pfam01266 655817008925 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 655817008926 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 655817008927 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 655817008928 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 655817008929 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 655817008930 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 655817008931 Ligand binding site [chemical binding]; other site 655817008932 Electron transfer flavoprotein domain; Region: ETF; pfam01012 655817008933 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 655817008934 benzoate transport; Region: 2A0115; TIGR00895 655817008935 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817008936 putative substrate translocation pore; other site 655817008937 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 655817008938 FAD binding domain; Region: FAD_binding_4; pfam01565 655817008939 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 655817008940 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 655817008941 NADP binding site [chemical binding]; other site 655817008942 homodimer interface [polypeptide binding]; other site 655817008943 active site 655817008944 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655817008945 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817008946 putative substrate translocation pore; other site 655817008947 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 655817008948 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 655817008949 nucleotide binding site [chemical binding]; other site 655817008950 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 655817008951 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 655817008952 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 655817008953 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 655817008954 Repair protein; Region: Repair_PSII; pfam04536 655817008955 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 655817008956 Repair protein; Region: Repair_PSII; pfam04536 655817008957 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 655817008958 Repair protein; Region: Repair_PSII; pfam04536 655817008959 enolase; Provisional; Region: eno; PRK00077 655817008960 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 655817008961 dimer interface [polypeptide binding]; other site 655817008962 metal binding site [ion binding]; metal-binding site 655817008963 substrate binding pocket [chemical binding]; other site 655817008964 CTP synthetase; Validated; Region: pyrG; PRK05380 655817008965 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 655817008966 Catalytic site [active] 655817008967 active site 655817008968 UTP binding site [chemical binding]; other site 655817008969 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 655817008970 active site 655817008971 putative oxyanion hole; other site 655817008972 catalytic triad [active] 655817008973 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 655817008974 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 655817008975 homodimer interface [polypeptide binding]; other site 655817008976 metal binding site [ion binding]; metal-binding site 655817008977 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 655817008978 homodimer interface [polypeptide binding]; other site 655817008979 active site 655817008980 putative chemical substrate binding site [chemical binding]; other site 655817008981 metal binding site [ion binding]; metal-binding site 655817008982 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 655817008983 HD domain; Region: HD_4; pfam13328 655817008984 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 655817008985 synthetase active site [active] 655817008986 NTP binding site [chemical binding]; other site 655817008987 metal binding site [ion binding]; metal-binding site 655817008988 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 655817008989 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 655817008990 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 655817008991 TRAM domain; Region: TRAM; pfam01938 655817008992 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817008993 S-adenosylmethionine binding site [chemical binding]; other site 655817008994 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 655817008995 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 655817008996 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655817008997 dimerization interface [polypeptide binding]; other site 655817008998 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817008999 dimer interface [polypeptide binding]; other site 655817009000 phosphorylation site [posttranslational modification] 655817009001 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817009002 ATP binding site [chemical binding]; other site 655817009003 Mg2+ binding site [ion binding]; other site 655817009004 G-X-G motif; other site 655817009005 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 655817009006 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817009007 active site 655817009008 phosphorylation site [posttranslational modification] 655817009009 intermolecular recognition site; other site 655817009010 dimerization interface [polypeptide binding]; other site 655817009011 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 655817009012 putative binding surface; other site 655817009013 active site 655817009014 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 655817009015 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 655817009016 active site 655817009017 tetramer interface [polypeptide binding]; other site 655817009018 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 655817009019 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 655817009020 active site 655817009021 tetramer interface [polypeptide binding]; other site 655817009022 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817009023 D-galactonate transporter; Region: 2A0114; TIGR00893 655817009024 putative substrate translocation pore; other site 655817009025 flavodoxin; Provisional; Region: PRK08105 655817009026 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 655817009027 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 655817009028 probable active site [active] 655817009029 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 655817009030 SecY interacting protein Syd; Provisional; Region: PRK04968 655817009031 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 655817009032 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 655817009033 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 655817009034 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 655817009035 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 655817009036 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 655817009037 serine transporter; Region: stp; TIGR00814 655817009038 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 655817009039 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 655817009040 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 655817009041 flap endonuclease-like protein; Provisional; Region: PRK09482 655817009042 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 655817009043 active site 655817009044 metal binding site 1 [ion binding]; metal-binding site 655817009045 putative 5' ssDNA interaction site; other site 655817009046 metal binding site 3; metal-binding site 655817009047 metal binding site 2 [ion binding]; metal-binding site 655817009048 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 655817009049 putative DNA binding site [nucleotide binding]; other site 655817009050 putative metal binding site [ion binding]; other site 655817009051 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 655817009052 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 655817009053 dimer interface [polypeptide binding]; other site 655817009054 active site 655817009055 metal binding site [ion binding]; metal-binding site 655817009056 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 655817009057 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 655817009058 intersubunit interface [polypeptide binding]; other site 655817009059 active site 655817009060 Zn2+ binding site [ion binding]; other site 655817009061 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 655817009062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817009063 putative substrate translocation pore; other site 655817009064 L-fucose isomerase; Provisional; Region: fucI; PRK10991 655817009065 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 655817009066 hexamer (dimer of trimers) interface [polypeptide binding]; other site 655817009067 trimer interface [polypeptide binding]; other site 655817009068 substrate binding site [chemical binding]; other site 655817009069 Mn binding site [ion binding]; other site 655817009070 L-fuculokinase; Provisional; Region: PRK10331 655817009071 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 655817009072 nucleotide binding site [chemical binding]; other site 655817009073 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 655817009074 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 655817009075 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 655817009076 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817009077 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 655817009078 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 655817009079 hypothetical protein; Provisional; Region: PRK10873 655817009080 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 655817009081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817009082 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 655817009083 dimerization interface [polypeptide binding]; other site 655817009084 substrate binding pocket [chemical binding]; other site 655817009085 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 655817009086 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 655817009087 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 655817009088 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655817009089 catalytic residue [active] 655817009090 CsdA-binding activator; Provisional; Region: PRK15019 655817009091 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 655817009092 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 655817009093 putative ATP binding site [chemical binding]; other site 655817009094 putative substrate interface [chemical binding]; other site 655817009095 murein transglycosylase A; Provisional; Region: mltA; PRK11162 655817009096 MltA specific insert domain; Region: MltA; pfam03562 655817009097 3D domain; Region: 3D; pfam06725 655817009098 Protein of unknown function (DUF770); Region: DUF770; pfam05591 655817009099 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 655817009100 Protein of unknown function (DUF877); Region: DUF877; pfam05943 655817009101 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 655817009102 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 655817009103 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 655817009104 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 655817009105 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 655817009106 ligand binding site [chemical binding]; other site 655817009107 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 655817009108 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 655817009109 Clp amino terminal domain; Region: Clp_N; pfam02861 655817009110 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817009111 Walker A motif; other site 655817009112 ATP binding site [chemical binding]; other site 655817009113 Walker B motif; other site 655817009114 arginine finger; other site 655817009115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817009116 Walker A motif; other site 655817009117 ATP binding site [chemical binding]; other site 655817009118 Walker B motif; other site 655817009119 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 655817009120 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 655817009121 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 655817009122 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 655817009123 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 655817009124 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 655817009125 PAAR motif; Region: PAAR_motif; pfam05488 655817009126 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 655817009127 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 655817009128 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 655817009129 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 655817009130 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 655817009131 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 655817009132 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 655817009133 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 655817009134 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 655817009135 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 655817009136 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 655817009137 ImpA domain protein; Region: DUF3702; pfam12486 655817009138 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 655817009139 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 655817009140 putative ligand binding site [chemical binding]; other site 655817009141 putative NAD binding site [chemical binding]; other site 655817009142 catalytic site [active] 655817009143 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 655817009144 putative active site [active] 655817009145 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 655817009146 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655817009147 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817009148 homodimer interface [polypeptide binding]; other site 655817009149 catalytic residue [active] 655817009150 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 655817009151 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655817009152 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655817009153 active site turn [active] 655817009154 phosphorylation site [posttranslational modification] 655817009155 CAT RNA binding domain; Region: CAT_RBD; pfam03123 655817009156 PRD domain; Region: PRD; pfam00874 655817009157 PRD domain; Region: PRD; pfam00874 655817009158 AMIN domain; Region: AMIN; pfam11741 655817009159 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 655817009160 active site 655817009161 metal binding site [ion binding]; metal-binding site 655817009162 N-acetylglutamate synthase; Validated; Region: PRK05279 655817009163 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 655817009164 putative feedback inhibition sensing region; other site 655817009165 putative nucleotide binding site [chemical binding]; other site 655817009166 putative substrate binding site [chemical binding]; other site 655817009167 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655817009168 Coenzyme A binding pocket [chemical binding]; other site 655817009169 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 655817009170 AAA domain; Region: AAA_30; pfam13604 655817009171 Family description; Region: UvrD_C_2; pfam13538 655817009172 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 655817009173 protease3; Provisional; Region: PRK15101 655817009174 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 655817009175 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 655817009176 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 655817009177 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 655817009178 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 655817009179 hypothetical protein; Provisional; Region: PRK10332 655817009180 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 655817009181 hypothetical protein; Provisional; Region: PRK11521 655817009182 hypothetical protein; Provisional; Region: PRK10557 655817009183 hypothetical protein; Provisional; Region: PRK10506 655817009184 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 655817009185 thymidylate synthase; Reviewed; Region: thyA; PRK01827 655817009186 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 655817009187 dimerization interface [polypeptide binding]; other site 655817009188 active site 655817009189 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 655817009190 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 655817009191 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 655817009192 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 655817009193 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 655817009194 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 655817009195 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 655817009196 putative active site [active] 655817009197 Ap4A binding site [chemical binding]; other site 655817009198 nudix motif; other site 655817009199 putative metal binding site [ion binding]; other site 655817009200 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 655817009201 putative DNA-binding cleft [nucleotide binding]; other site 655817009202 putative DNA clevage site; other site 655817009203 molecular lever; other site 655817009204 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 655817009205 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 655817009206 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655817009207 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655817009208 active site 655817009209 catalytic tetrad [active] 655817009210 lysophospholipid transporter LplT; Provisional; Region: PRK11195 655817009211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817009212 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 655817009213 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 655817009214 putative acyl-acceptor binding pocket; other site 655817009215 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 655817009216 acyl-activating enzyme (AAE) consensus motif; other site 655817009217 putative AMP binding site [chemical binding]; other site 655817009218 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 655817009219 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817009220 DNA binding site [nucleotide binding] 655817009221 domain linker motif; other site 655817009222 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 655817009223 dimerization interface (closed form) [polypeptide binding]; other site 655817009224 ligand binding site [chemical binding]; other site 655817009225 diaminopimelate decarboxylase; Provisional; Region: PRK11165 655817009226 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 655817009227 active site 655817009228 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 655817009229 substrate binding site [chemical binding]; other site 655817009230 catalytic residues [active] 655817009231 dimer interface [polypeptide binding]; other site 655817009232 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 655817009233 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817009234 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655817009235 dimerization interface [polypeptide binding]; other site 655817009236 putative racemase; Provisional; Region: PRK10200 655817009237 aspartate racemase; Region: asp_race; TIGR00035 655817009238 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 655817009239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817009240 putative substrate translocation pore; other site 655817009241 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817009242 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 655817009243 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 655817009244 NADP binding site [chemical binding]; other site 655817009245 homodimer interface [polypeptide binding]; other site 655817009246 active site 655817009247 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 655817009248 putative acyltransferase; Provisional; Region: PRK05790 655817009249 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 655817009250 dimer interface [polypeptide binding]; other site 655817009251 active site 655817009252 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 655817009253 serine transporter; Region: stp; TIGR00814 655817009254 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 655817009255 Peptidase family M23; Region: Peptidase_M23; pfam01551 655817009256 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 655817009257 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 655817009258 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 655817009259 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 655817009260 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 655817009261 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 655817009262 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 655817009263 catalytic loop [active] 655817009264 iron binding site [ion binding]; other site 655817009265 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 655817009266 GAF domain; Region: GAF; cl17456 655817009267 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 655817009268 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655817009269 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817009270 Walker A motif; other site 655817009271 ATP binding site [chemical binding]; other site 655817009272 Walker B motif; other site 655817009273 arginine finger; other site 655817009274 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 655817009275 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 655817009276 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 655817009277 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 655817009278 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 655817009279 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 655817009280 catalytic residue [active] 655817009281 peptidase; Reviewed; Region: PRK13004 655817009282 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 655817009283 putative metal binding site [ion binding]; other site 655817009284 putative dimer interface [polypeptide binding]; other site 655817009285 D-hydantoinase; Region: D-hydantoinase; TIGR02033 655817009286 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 655817009287 tetramer interface [polypeptide binding]; other site 655817009288 active site 655817009289 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 655817009290 carbamate kinase; Reviewed; Region: PRK12686 655817009291 putative substrate binding site [chemical binding]; other site 655817009292 homodimer interface [polypeptide binding]; other site 655817009293 nucleotide binding site [chemical binding]; other site 655817009294 nucleotide binding site [chemical binding]; other site 655817009295 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 655817009296 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 655817009297 XdhC Rossmann domain; Region: XdhC_C; pfam13478 655817009298 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 655817009299 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 655817009300 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 655817009301 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 655817009302 metal-binding site 655817009303 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 655817009304 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 655817009305 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655817009306 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 655817009307 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 655817009308 active site 655817009309 putative substrate binding pocket [chemical binding]; other site 655817009310 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 655817009311 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 655817009312 putative hypoxanthine oxidase; Provisional; Region: PRK09800 655817009313 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 655817009314 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 655817009315 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 655817009316 uracil-xanthine permease; Region: ncs2; TIGR00801 655817009317 guanine deaminase; Provisional; Region: PRK09228 655817009318 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 655817009319 active site 655817009320 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 655817009321 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 655817009322 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 655817009323 4Fe-4S binding domain; Region: Fer4; pfam00037 655817009324 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 655817009325 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817009326 xanthine permease; Region: pbuX; TIGR03173 655817009327 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 655817009328 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 655817009329 active site 655817009330 metal binding site [ion binding]; metal-binding site 655817009331 nudix motif; other site 655817009332 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 655817009333 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 655817009334 dimer interface [polypeptide binding]; other site 655817009335 putative anticodon binding site; other site 655817009336 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 655817009337 motif 1; other site 655817009338 active site 655817009339 motif 2; other site 655817009340 motif 3; other site 655817009341 peptide chain release factor 2; Provisional; Region: PRK08787 655817009342 This domain is found in peptide chain release factors; Region: PCRF; smart00937 655817009343 RF-1 domain; Region: RF-1; pfam00472 655817009344 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 655817009345 DHH family; Region: DHH; pfam01368 655817009346 DHHA1 domain; Region: DHHA1; pfam02272 655817009347 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 655817009348 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 655817009349 dimerization domain [polypeptide binding]; other site 655817009350 dimer interface [polypeptide binding]; other site 655817009351 catalytic residues [active] 655817009352 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 655817009353 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 655817009354 active site 655817009355 Int/Topo IB signature motif; other site 655817009356 flavodoxin FldB; Provisional; Region: PRK12359 655817009357 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 655817009358 hypothetical protein; Provisional; Region: PRK10878 655817009359 putative global regulator; Reviewed; Region: PRK09559 655817009360 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 655817009361 hemolysin; Provisional; Region: PRK15087 655817009362 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 655817009363 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 655817009364 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 655817009365 beta-galactosidase; Region: BGL; TIGR03356 655817009366 glycine dehydrogenase; Provisional; Region: PRK05367 655817009367 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 655817009368 tetramer interface [polypeptide binding]; other site 655817009369 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817009370 catalytic residue [active] 655817009371 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 655817009372 tetramer interface [polypeptide binding]; other site 655817009373 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817009374 catalytic residue [active] 655817009375 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 655817009376 lipoyl attachment site [posttranslational modification]; other site 655817009377 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 655817009378 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 655817009379 oxidoreductase; Provisional; Region: PRK08013 655817009380 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 655817009381 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 655817009382 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 655817009383 proline aminopeptidase P II; Provisional; Region: PRK10879 655817009384 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 655817009385 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 655817009386 active site 655817009387 hypothetical protein; Reviewed; Region: PRK01736 655817009388 Z-ring-associated protein; Provisional; Region: PRK10972 655817009389 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 655817009390 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 655817009391 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 655817009392 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 655817009393 ligand binding site [chemical binding]; other site 655817009394 NAD binding site [chemical binding]; other site 655817009395 tetramer interface [polypeptide binding]; other site 655817009396 catalytic site [active] 655817009397 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 655817009398 L-serine binding site [chemical binding]; other site 655817009399 ACT domain interface; other site 655817009400 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 655817009401 tetramer (dimer of dimers) interface [polypeptide binding]; other site 655817009402 active site 655817009403 dimer interface [polypeptide binding]; other site 655817009404 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 655817009405 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817009406 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 655817009407 putative dimerization interface [polypeptide binding]; other site 655817009408 potential frameshift: common BLAST hit: gi|260869592|ref|YP_003235994.1| methylmalonyl-CoA mutase 655817009409 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 655817009410 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 655817009411 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817009412 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655817009413 Uncharacterized conserved protein [Function unknown]; Region: COG2968 655817009414 oxidative stress defense protein; Provisional; Region: PRK11087 655817009415 arginine exporter protein; Provisional; Region: PRK09304 655817009416 mechanosensitive channel MscS; Provisional; Region: PRK10334 655817009417 Mechanosensitive ion channel; Region: MS_channel; pfam00924 655817009418 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 655817009419 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 655817009420 active site 655817009421 intersubunit interface [polypeptide binding]; other site 655817009422 zinc binding site [ion binding]; other site 655817009423 Na+ binding site [ion binding]; other site 655817009424 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 655817009425 Phosphoglycerate kinase; Region: PGK; pfam00162 655817009426 substrate binding site [chemical binding]; other site 655817009427 hinge regions; other site 655817009428 ADP binding site [chemical binding]; other site 655817009429 catalytic site [active] 655817009430 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 655817009431 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 655817009432 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 655817009433 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 655817009434 trimer interface [polypeptide binding]; other site 655817009435 putative Zn binding site [ion binding]; other site 655817009436 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 655817009437 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 655817009438 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 655817009439 Walker A/P-loop; other site 655817009440 ATP binding site [chemical binding]; other site 655817009441 Q-loop/lid; other site 655817009442 ABC transporter signature motif; other site 655817009443 Walker B; other site 655817009444 D-loop; other site 655817009445 H-loop/switch region; other site 655817009446 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 655817009447 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 655817009448 Walker A/P-loop; other site 655817009449 ATP binding site [chemical binding]; other site 655817009450 Q-loop/lid; other site 655817009451 ABC transporter signature motif; other site 655817009452 Walker B; other site 655817009453 D-loop; other site 655817009454 H-loop/switch region; other site 655817009455 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 655817009456 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 655817009457 active site 655817009458 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 655817009459 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 655817009460 FIG, FBPase/IMPase/glpX-like domain. A superfamily of metal-dependent phosphatases with various substrates. Fructose-1,6-bisphospatase (both the major and the glpX-encoded variant) hydrolyze fructose-1,6,-bisphosphate to fructose-6-phosphate in...; Region: FIG; cl00289 655817009461 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 655817009462 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655817009463 putative NAD(P) binding site [chemical binding]; other site 655817009464 catalytic Zn binding site [ion binding]; other site 655817009465 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 655817009466 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 655817009467 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 655817009468 active site 655817009469 P-loop; other site 655817009470 phosphorylation site [posttranslational modification] 655817009471 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655817009472 active site 655817009473 phosphorylation site [posttranslational modification] 655817009474 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 655817009475 SPFH domain / Band 7 family; Region: Band_7; pfam01145 655817009476 transketolase; Reviewed; Region: PRK12753 655817009477 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 655817009478 TPP-binding site [chemical binding]; other site 655817009479 dimer interface [polypeptide binding]; other site 655817009480 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 655817009481 PYR/PP interface [polypeptide binding]; other site 655817009482 dimer interface [polypeptide binding]; other site 655817009483 TPP binding site [chemical binding]; other site 655817009484 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655817009485 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 655817009486 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 655817009487 agmatinase; Region: agmatinase; TIGR01230 655817009488 oligomer interface [polypeptide binding]; other site 655817009489 putative active site [active] 655817009490 Mn binding site [ion binding]; other site 655817009491 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 655817009492 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 655817009493 dimer interface [polypeptide binding]; other site 655817009494 active site 655817009495 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 655817009496 catalytic residues [active] 655817009497 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 655817009498 Virulence promoting factor; Region: YqgB; pfam11036 655817009499 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 655817009500 S-adenosylmethionine synthetase; Validated; Region: PRK05250 655817009501 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 655817009502 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 655817009503 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 655817009504 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 655817009505 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817009506 putative substrate translocation pore; other site 655817009507 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817009508 hypothetical protein; Provisional; Region: PRK04860 655817009509 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 655817009510 DNA-specific endonuclease I; Provisional; Region: PRK15137 655817009511 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 655817009512 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 655817009513 RNA methyltransferase, RsmE family; Region: TIGR00046 655817009514 glutathione synthetase; Provisional; Region: PRK05246 655817009515 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 655817009516 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 655817009517 hypothetical protein; Validated; Region: PRK00228 655817009518 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 655817009519 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 655817009520 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 655817009521 Walker A motif; other site 655817009522 ATP binding site [chemical binding]; other site 655817009523 Walker B motif; other site 655817009524 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 655817009525 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 655817009526 catalytic residue [active] 655817009527 YGGT family; Region: YGGT; pfam02325 655817009528 YGGT family; Region: YGGT; pfam02325 655817009529 hypothetical protein; Validated; Region: PRK05090 655817009530 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 655817009531 active site 655817009532 dimerization interface [polypeptide binding]; other site 655817009533 HemN family oxidoreductase; Provisional; Region: PRK05660 655817009534 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817009535 FeS/SAM binding site; other site 655817009536 HemN C-terminal domain; Region: HemN_C; pfam06969 655817009537 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 655817009538 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 655817009539 homodimer interface [polypeptide binding]; other site 655817009540 active site 655817009541 hypothetical protein; Provisional; Region: PRK10626 655817009542 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 655817009543 hypothetical protein; Provisional; Region: PRK11702 655817009544 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 655817009545 adenine DNA glycosylase; Provisional; Region: PRK10880 655817009546 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 655817009547 minor groove reading motif; other site 655817009548 helix-hairpin-helix signature motif; other site 655817009549 substrate binding pocket [chemical binding]; other site 655817009550 active site 655817009551 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 655817009552 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 655817009553 DNA binding and oxoG recognition site [nucleotide binding] 655817009554 oxidative damage protection protein; Provisional; Region: PRK05408 655817009555 murein transglycosylase C; Provisional; Region: mltC; PRK11671 655817009556 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 655817009557 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 655817009558 N-acetyl-D-glucosamine binding site [chemical binding]; other site 655817009559 catalytic residue [active] 655817009560 nucleoside transporter; Region: 2A0110; TIGR00889 655817009561 ornithine decarboxylase; Provisional; Region: PRK13578 655817009562 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 655817009563 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 655817009564 homodimer interface [polypeptide binding]; other site 655817009565 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817009566 catalytic residue [active] 655817009567 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 655817009568 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 655817009569 integrase; Provisional; Region: PRK09692 655817009570 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 655817009571 active site 655817009572 Int/Topo IB signature motif; other site 655817009573 DNA primase; Validated; Region: dnaG; PRK05667 655817009574 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 655817009575 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 655817009576 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 655817009577 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 655817009578 MarR family; Region: MarR_2; cl17246 655817009579 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655817009580 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 655817009581 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 655817009582 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 655817009583 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 655817009584 potential frameshift: common BLAST hit: gi|218702822|ref|YP_002410451.1| major pilin protein PapA 655817009585 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817009586 Adhesin biosynthesis transcription regulatory protein; Region: PapB; cl04012 655817009587 FaeA-like protein; Region: FaeA; pfam04703 655817009588 HTH-like domain; Region: HTH_21; pfam13276 655817009589 Integrase core domain; Region: rve; pfam00665 655817009590 Integrase core domain; Region: rve_3; cl15866 655817009591 Transposase; Region: HTH_Tnp_1; cl17663 655817009592 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 655817009593 Transposase; Region: DDE_Tnp_ISL3; pfam01610 655817009594 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 655817009595 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 655817009596 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655817009597 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817009598 Protein of unknown function, DUF417; Region: DUF417; pfam04224 655817009599 IS2 repressor TnpA; Reviewed; Region: PRK09413 655817009600 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 655817009601 IS2 transposase TnpB; Reviewed; Region: PRK09409 655817009602 HTH-like domain; Region: HTH_21; pfam13276 655817009603 Integrase core domain; Region: rve; pfam00665 655817009604 Integrase core domain; Region: rve_3; pfam13683 655817009605 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817009606 Major Facilitator Superfamily; Region: MFS_1; pfam07690 655817009607 putative substrate translocation pore; other site 655817009608 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 655817009609 IucA / IucC family; Region: IucA_IucC; pfam04183 655817009610 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 655817009611 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 655817009612 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 655817009613 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 655817009614 IucA / IucC family; Region: IucA_IucC; pfam04183 655817009615 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 655817009616 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 655817009617 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655817009618 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 655817009619 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817009620 N-terminal plug; other site 655817009621 ligand-binding site [chemical binding]; other site 655817009622 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 655817009623 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 655817009624 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 655817009625 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 655817009626 Autotransporter beta-domain; Region: Autotransporter; pfam03797 655817009627 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 655817009628 Transposase; Region: HTH_Tnp_1; pfam01527 655817009629 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 655817009630 Helix-turn-helix domain; Region: HTH_38; pfam13936 655817009631 Integrase core domain; Region: rve; pfam00665 655817009632 putative transposase OrfB; Reviewed; Region: PHA02517 655817009633 Integrase core domain; Region: rve; pfam00665 655817009634 Integrase core domain; Region: rve_3; pfam13683 655817009635 potential frameshift: common BLAST hit: gi|307130519|ref|YP_003882535.1| transposase, IS3 family 655817009636 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 655817009637 Transposase; Region: HTH_Tnp_1; cl17663 655817009638 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 655817009639 HTH-like domain; Region: HTH_21; pfam13276 655817009640 Integrase core domain; Region: rve; pfam00665 655817009641 Integrase core domain; Region: rve_2; pfam13333 655817009642 L-lactate permease; Region: Lactate_perm; cl00701 655817009643 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 655817009644 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 655817009645 DEXH box helicase, DNA ligase-associated; Region: DEXH_lig_assoc; TIGR04121 655817009646 bifunctional enterobactin receptor/adhesin protein; Provisional; Region: PRK13486 655817009647 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817009648 N-terminal plug; other site 655817009649 ligand-binding site [chemical binding]; other site 655817009650 IS2 transposase TnpB; Reviewed; Region: PRK09409 655817009651 HTH-like domain; Region: HTH_21; pfam13276 655817009652 Integrase core domain; Region: rve; pfam00665 655817009653 Integrase core domain; Region: rve_3; pfam13683 655817009654 IS2 repressor TnpA; Reviewed; Region: PRK09413 655817009655 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 655817009656 Domain of unknown function (DUF303); Region: DUF303; pfam03629 655817009657 transcriptional regulator NanR; Provisional; Region: PRK03837 655817009658 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817009659 DNA-binding site [nucleotide binding]; DNA binding site 655817009660 FCD domain; Region: FCD; pfam07729 655817009661 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 655817009662 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 655817009663 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 655817009664 Kelch motif; Region: Kelch_1; pfam01344 655817009665 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; pfam06178 655817009666 Alpha/beta hydrolase family; Region: Abhydrolase_5; pfam12695 655817009667 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 655817009668 putative sialic acid transporter; Provisional; Region: PRK03893 655817009669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817009670 putative substrate translocation pore; other site 655817009671 N-acetylmannosamine kinase; Provisional; Region: PRK05082 655817009672 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655817009673 nucleotide binding site [chemical binding]; other site 655817009674 N-acetylneuraminate lyase; Provisional; Region: PRK04147 655817009675 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 655817009676 inhibitor site; inhibition site 655817009677 active site 655817009678 dimer interface [polypeptide binding]; other site 655817009679 catalytic residue [active] 655817009680 Transposase; Region: HTH_Tnp_1; pfam01527 655817009681 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 655817009682 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 655817009683 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 655817009684 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 655817009685 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 655817009686 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 655817009687 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 655817009688 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 655817009689 homodimer interface [polypeptide binding]; other site 655817009690 putative GKAP docking site [polypeptide binding]; other site 655817009691 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 655817009692 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 655817009693 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 655817009694 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 655817009695 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 655817009696 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 655817009697 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 655817009698 Haemolysin expression modulating protein; Region: HHA; pfam05321 655817009699 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 655817009700 Protein of unknown function (DUF3987); Region: DUF3987; pfam13148 655817009701 Predicted GTPase [General function prediction only]; Region: COG3596 655817009702 YfjP GTPase; Region: YfjP; cd11383 655817009703 G1 box; other site 655817009704 GTP/Mg2+ binding site [chemical binding]; other site 655817009705 Switch I region; other site 655817009706 G2 box; other site 655817009707 Switch II region; other site 655817009708 G3 box; other site 655817009709 G4 box; other site 655817009710 G5 box; other site 655817009711 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 655817009712 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 655817009713 hypothetical protein; Provisional; Region: PRK09945 655817009714 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 655817009715 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 655817009716 Autotransporter beta-domain; Region: Autotransporter; smart00869 655817009717 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 655817009718 Domain of unknown function (DUF932); Region: DUF932; pfam06067 655817009719 Antirestriction protein; Region: Antirestrict; pfam03230 655817009720 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 655817009721 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 655817009722 MPN+ (JAMM) motif; other site 655817009723 Zinc-binding site [ion binding]; other site 655817009724 Protein of unknown function (DUF987); Region: DUF987; pfam06174 655817009725 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 655817009726 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 655817009727 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 655817009728 Methyltransferase domain; Region: Methyltransf_27; pfam13708 655817009729 Nucleotidyl transferase of unknown function (DUF1814); Region: DUF1814; pfam08843 655817009730 KpsF/GutQ family protein; Region: kpsF; TIGR00393 655817009731 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 655817009732 putative active site [active] 655817009733 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 655817009734 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 655817009735 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 655817009736 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 655817009737 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 655817009738 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 655817009739 Ligand binding site; other site 655817009740 oligomer interface; other site 655817009741 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 655817009742 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 655817009743 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 655817009744 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 655817009745 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 655817009746 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 655817009747 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 655817009748 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 655817009749 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655817009750 active site 655817009751 Integrase core domain; Region: rve; pfam00665 655817009752 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 655817009753 active site 655817009754 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 655817009755 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 655817009756 Walker A/P-loop; other site 655817009757 ATP binding site [chemical binding]; other site 655817009758 Q-loop/lid; other site 655817009759 ABC transporter signature motif; other site 655817009760 Walker B; other site 655817009761 D-loop; other site 655817009762 H-loop/switch region; other site 655817009763 ABC-2 type transporter; Region: ABC2_membrane; cl17235 655817009764 Type II secretion system (T2SS), protein M; Region: T2SM; cl01222 655817009765 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 655817009766 GspL-like protein; Provisional; Region: PRK09662 655817009767 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 655817009768 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 655817009769 type II secretion system protein J; Region: gspJ; TIGR01711 655817009770 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 655817009771 type II secretion system protein I; Region: gspI; TIGR01707 655817009772 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 655817009773 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 655817009774 Type II transport protein GspH; Region: GspH; pfam12019 655817009775 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 655817009776 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 655817009777 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 655817009778 type II secretion system protein F; Region: GspF; TIGR02120 655817009779 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 655817009780 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 655817009781 type II secretion system protein E; Region: type_II_gspE; TIGR02533 655817009782 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 655817009783 Walker A motif; other site 655817009784 ATP binding site [chemical binding]; other site 655817009785 Walker B motif; other site 655817009786 type II secretion system protein D; Region: type_II_gspD; TIGR02517 655817009787 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 655817009788 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 655817009789 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 655817009790 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 655817009791 putative type II secretion protein GspC; Provisional; Region: PRK09681 655817009792 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 655817009793 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655817009794 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 655817009795 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 655817009796 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 655817009797 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 655817009798 Peptidase M60-like family; Region: M60-like; pfam13402 655817009799 glycolate transporter; Provisional; Region: PRK09695 655817009800 L-lactate permease; Region: Lactate_perm; cl00701 655817009801 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 655817009802 active site 655817009803 hypothetical protein; Provisional; Region: PRK09732 655817009804 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 655817009805 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 655817009806 Cysteine-rich domain; Region: CCG; pfam02754 655817009807 Cysteine-rich domain; Region: CCG; pfam02754 655817009808 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 655817009809 FAD binding domain; Region: FAD_binding_4; pfam01565 655817009810 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 655817009811 FAD binding domain; Region: FAD_binding_4; pfam01565 655817009812 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 655817009813 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817009814 DNA-binding site [nucleotide binding]; DNA binding site 655817009815 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 655817009816 acyl-CoA synthetase; Validated; Region: PRK09192 655817009817 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 655817009818 acyl-activating enzyme (AAE) consensus motif; other site 655817009819 active site 655817009820 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 655817009821 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 655817009822 NAD(P) binding site [chemical binding]; other site 655817009823 active site 655817009824 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 655817009825 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 655817009826 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 655817009827 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655817009828 catalytic residue [active] 655817009829 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 655817009830 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 655817009831 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 655817009832 Predicted permeases [General function prediction only]; Region: COG0795 655817009833 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 655817009834 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 655817009835 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 655817009836 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 655817009837 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 655817009838 active site 655817009839 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 655817009840 thymidylate kinase; Validated; Region: tmk; PRK00698 655817009841 TMP-binding site; other site 655817009842 ATP-binding site [chemical binding]; other site 655817009843 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 655817009844 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 655817009845 TMP-binding site; other site 655817009846 ATP-binding site [chemical binding]; other site 655817009847 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 655817009848 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 655817009849 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 655817009850 CHAP domain; Region: CHAP; pfam05257 655817009851 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 655817009852 putative S-transferase; Provisional; Region: PRK11752 655817009853 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 655817009854 C-terminal domain interface [polypeptide binding]; other site 655817009855 GSH binding site (G-site) [chemical binding]; other site 655817009856 dimer interface [polypeptide binding]; other site 655817009857 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 655817009858 dimer interface [polypeptide binding]; other site 655817009859 N-terminal domain interface [polypeptide binding]; other site 655817009860 active site 655817009861 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 655817009862 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 655817009863 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 655817009864 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 655817009865 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 655817009866 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 655817009867 putative substrate-binding site; other site 655817009868 nickel binding site [ion binding]; other site 655817009869 hydrogenase 2 large subunit; Provisional; Region: PRK10467 655817009870 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 655817009871 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 655817009872 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 655817009873 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 655817009874 4Fe-4S binding domain; Region: Fer4_6; pfam12837 655817009875 hydrogenase 2 small subunit; Provisional; Region: PRK10468 655817009876 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 655817009877 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 655817009878 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 655817009879 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 655817009880 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 655817009881 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655817009882 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655817009883 active site 655817009884 catalytic tetrad [active] 655817009885 hypothetical protein; Provisional; Region: PRK05208 655817009886 oxidoreductase; Provisional; Region: PRK07985 655817009887 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 655817009888 NAD binding site [chemical binding]; other site 655817009889 metal binding site [ion binding]; metal-binding site 655817009890 active site 655817009891 biopolymer transport protein ExbD; Provisional; Region: PRK11267 655817009892 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 655817009893 biopolymer transport protein ExbB; Provisional; Region: PRK10414 655817009894 cystathionine beta-lyase; Provisional; Region: PRK08114 655817009895 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 655817009896 homodimer interface [polypeptide binding]; other site 655817009897 substrate-cofactor binding pocket; other site 655817009898 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817009899 catalytic residue [active] 655817009900 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 655817009901 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 655817009902 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 655817009903 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 655817009904 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817009905 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817009906 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 655817009907 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 655817009908 dimer interface [polypeptide binding]; other site 655817009909 active site 655817009910 metal binding site [ion binding]; metal-binding site 655817009911 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 655817009912 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 655817009913 active site 655817009914 catalytic tetrad [active] 655817009915 putative outer membrane lipoprotein; Provisional; Region: PRK09973 655817009916 hypothetical protein; Provisional; Region: PRK01254 655817009917 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 655817009918 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 655817009919 Transcriptional regulators [Transcription]; Region: FadR; COG2186 655817009920 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817009921 DNA-binding site [nucleotide binding]; DNA binding site 655817009922 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 655817009923 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 655817009924 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 655817009925 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 655817009926 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655817009927 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 655817009928 putative NAD(P) binding site [chemical binding]; other site 655817009929 catalytic Zn binding site [ion binding]; other site 655817009930 structural Zn binding site [ion binding]; other site 655817009931 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 655817009932 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 655817009933 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 655817009934 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 655817009935 DctM-like transporters; Region: DctM; pfam06808 655817009936 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 655817009937 FtsI repressor; Provisional; Region: PRK10883 655817009938 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 655817009939 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 655817009940 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 655817009941 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 655817009942 putative acyl-acceptor binding pocket; other site 655817009943 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 655817009944 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 655817009945 CAP-like domain; other site 655817009946 active site 655817009947 primary dimer interface [polypeptide binding]; other site 655817009948 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 655817009949 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 655817009950 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 655817009951 peptide binding site [polypeptide binding]; other site 655817009952 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 655817009953 TIGR00156 family protein; Region: TIGR00156 655817009954 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 655817009955 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817009956 active site 655817009957 phosphorylation site [posttranslational modification] 655817009958 intermolecular recognition site; other site 655817009959 dimerization interface [polypeptide binding]; other site 655817009960 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817009961 DNA binding site [nucleotide binding] 655817009962 sensor protein QseC; Provisional; Region: PRK10337 655817009963 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817009964 dimer interface [polypeptide binding]; other site 655817009965 phosphorylation site [posttranslational modification] 655817009966 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817009967 ATP binding site [chemical binding]; other site 655817009968 Mg2+ binding site [ion binding]; other site 655817009969 G-X-G motif; other site 655817009970 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 655817009971 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 655817009972 Uncharacterized conserved protein [Function unknown]; Region: COG1359 655817009973 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 655817009974 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 655817009975 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 655817009976 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 655817009977 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 655817009978 siderophore binding site; other site 655817009979 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 655817009980 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817009981 ABC-ATPase subunit interface; other site 655817009982 dimer interface [polypeptide binding]; other site 655817009983 putative PBP binding regions; other site 655817009984 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 655817009985 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817009986 dimer interface [polypeptide binding]; other site 655817009987 putative PBP binding regions; other site 655817009988 ABC-ATPase subunit interface; other site 655817009989 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 655817009990 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655817009991 Walker A/P-loop; other site 655817009992 ATP binding site [chemical binding]; other site 655817009993 Q-loop/lid; other site 655817009994 ABC transporter signature motif; other site 655817009995 Walker B; other site 655817009996 D-loop; other site 655817009997 H-loop/switch region; other site 655817009998 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 655817009999 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817010000 N-terminal plug; other site 655817010001 ligand-binding site [chemical binding]; other site 655817010002 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 655817010003 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817010004 ATP binding site [chemical binding]; other site 655817010005 Mg2+ binding site [ion binding]; other site 655817010006 G-X-G motif; other site 655817010007 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 655817010008 anchoring element; other site 655817010009 dimer interface [polypeptide binding]; other site 655817010010 ATP binding site [chemical binding]; other site 655817010011 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 655817010012 active site 655817010013 metal binding site [ion binding]; metal-binding site 655817010014 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 655817010015 esterase YqiA; Provisional; Region: PRK11071 655817010016 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 655817010017 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 655817010018 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 655817010019 active site 655817010020 metal binding site [ion binding]; metal-binding site 655817010021 hexamer interface [polypeptide binding]; other site 655817010022 putative dehydrogenase; Provisional; Region: PRK11039 655817010023 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 655817010024 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 655817010025 dimer interface [polypeptide binding]; other site 655817010026 ADP-ribose binding site [chemical binding]; other site 655817010027 active site 655817010028 nudix motif; other site 655817010029 metal binding site [ion binding]; metal-binding site 655817010030 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 655817010031 hypothetical protein; Provisional; Region: PRK11653 655817010032 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 655817010033 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 655817010034 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 655817010035 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 655817010036 catalytic residues [active] 655817010037 hinge region; other site 655817010038 alpha helical domain; other site 655817010039 putative disulfide oxidoreductase; Provisional; Region: PRK04307 655817010040 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 655817010041 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 655817010042 putative active site [active] 655817010043 metal binding site [ion binding]; metal-binding site 655817010044 zinc transporter ZupT; Provisional; Region: PRK04201 655817010045 ZIP Zinc transporter; Region: Zip; pfam02535 655817010046 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 655817010047 putative fimbrial protein; Provisional; Region: PRK09733 655817010048 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 655817010049 PapC N-terminal domain; Region: PapC_N; pfam13954 655817010050 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 655817010051 PapC C-terminal domain; Region: PapC_C; pfam13953 655817010052 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 655817010053 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 655817010054 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 655817010055 Fimbrial protein; Region: Fimbrial; pfam00419 655817010056 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 655817010057 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 655817010058 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 655817010059 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 655817010060 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 655817010061 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 655817010062 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 655817010063 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 655817010064 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 655817010065 putative ribose interaction site [chemical binding]; other site 655817010066 putative ADP binding site [chemical binding]; other site 655817010067 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 655817010068 active site 655817010069 nucleotide binding site [chemical binding]; other site 655817010070 HIGH motif; other site 655817010071 KMSKS motif; other site 655817010072 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 655817010073 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 655817010074 metal binding triad; other site 655817010075 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 655817010076 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 655817010077 metal binding triad; other site 655817010078 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 655817010079 Uncharacterized conserved protein [Function unknown]; Region: COG3025 655817010080 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 655817010081 putative active site [active] 655817010082 putative metal binding residues [ion binding]; other site 655817010083 signature motif; other site 655817010084 putative triphosphate binding site [ion binding]; other site 655817010085 CHAD domain; Region: CHAD; pfam05235 655817010086 Transposase IS200 like; Region: Y1_Tnp; pfam01797 655817010087 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 655817010088 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 655817010089 Probable transposase; Region: OrfB_IS605; pfam01385 655817010090 SH3 domain-containing protein; Provisional; Region: PRK10884 655817010091 Bacterial SH3 domain homologues; Region: SH3b; smart00287 655817010092 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 655817010093 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 655817010094 active site 655817010095 NTP binding site [chemical binding]; other site 655817010096 metal binding triad [ion binding]; metal-binding site 655817010097 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 655817010098 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655817010099 Zn2+ binding site [ion binding]; other site 655817010100 Mg2+ binding site [ion binding]; other site 655817010101 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 655817010102 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 655817010103 homooctamer interface [polypeptide binding]; other site 655817010104 active site 655817010105 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 655817010106 transcriptional activator TtdR; Provisional; Region: PRK09801 655817010107 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817010108 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 655817010109 putative effector binding pocket; other site 655817010110 putative dimerization interface [polypeptide binding]; other site 655817010111 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 655817010112 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 655817010113 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 655817010114 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 655817010115 transmembrane helices; other site 655817010116 UGMP family protein; Validated; Region: PRK09604 655817010117 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 655817010118 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 655817010119 DNA primase; Validated; Region: dnaG; PRK05667 655817010120 CHC2 zinc finger; Region: zf-CHC2; pfam01807 655817010121 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 655817010122 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 655817010123 active site 655817010124 metal binding site [ion binding]; metal-binding site 655817010125 interdomain interaction site; other site 655817010126 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 655817010127 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 655817010128 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 655817010129 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 655817010130 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 655817010131 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 655817010132 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655817010133 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 655817010134 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655817010135 DNA binding residues [nucleotide binding] 655817010136 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 655817010137 active site 655817010138 SUMO-1 interface [polypeptide binding]; other site 655817010139 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 655817010140 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 655817010141 FAD binding pocket [chemical binding]; other site 655817010142 FAD binding motif [chemical binding]; other site 655817010143 phosphate binding motif [ion binding]; other site 655817010144 NAD binding pocket [chemical binding]; other site 655817010145 Predicted transcriptional regulators [Transcription]; Region: COG1695 655817010146 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 655817010147 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655817010148 PAS fold; Region: PAS_3; pfam08447 655817010149 putative active site [active] 655817010150 heme pocket [chemical binding]; other site 655817010151 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 655817010152 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 655817010153 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655817010154 dimer interface [polypeptide binding]; other site 655817010155 putative CheW interface [polypeptide binding]; other site 655817010156 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 655817010157 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655817010158 inhibitor-cofactor binding pocket; inhibition site 655817010159 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817010160 catalytic residue [active] 655817010161 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 655817010162 dimer interface [polypeptide binding]; other site 655817010163 putative tRNA-binding site [nucleotide binding]; other site 655817010164 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 655817010165 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817010166 DNA binding site [nucleotide binding] 655817010167 domain linker motif; other site 655817010168 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 655817010169 putative dimerization interface [polypeptide binding]; other site 655817010170 putative ligand binding site [chemical binding]; other site 655817010171 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 655817010172 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 655817010173 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 655817010174 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 655817010175 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 655817010176 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 655817010177 inner membrane transporter YjeM; Provisional; Region: PRK15238 655817010178 alpha-glucosidase; Provisional; Region: PRK10137 655817010179 Protein of unknown function, DUF608; Region: DUF608; pfam04685 655817010180 Trehalase; Region: Trehalase; cl17346 655817010181 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 655817010182 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 655817010183 active site 655817010184 FMN binding site [chemical binding]; other site 655817010185 2,4-decadienoyl-CoA binding site; other site 655817010186 catalytic residue [active] 655817010187 4Fe-4S cluster binding site [ion binding]; other site 655817010188 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 655817010189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655817010190 non-specific DNA binding site [nucleotide binding]; other site 655817010191 salt bridge; other site 655817010192 sequence-specific DNA binding site [nucleotide binding]; other site 655817010193 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 655817010194 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817010195 S-adenosylmethionine binding site [chemical binding]; other site 655817010196 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 655817010197 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 655817010198 putative active site [active] 655817010199 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 655817010200 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655817010201 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 655817010202 serine/threonine transporter SstT; Provisional; Region: PRK13628 655817010203 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 655817010204 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 655817010205 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 655817010206 galactarate dehydratase; Region: galactar-dH20; TIGR03248 655817010207 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 655817010208 Glucuronate isomerase; Region: UxaC; pfam02614 655817010209 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 655817010210 D-galactonate transporter; Region: 2A0114; TIGR00893 655817010211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817010212 putative substrate translocation pore; other site 655817010213 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 655817010214 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817010215 DNA-binding site [nucleotide binding]; DNA binding site 655817010216 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 655817010217 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 655817010218 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 655817010219 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 655817010220 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 655817010221 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 655817010222 Predicted membrane protein [Function unknown]; Region: COG5393 655817010223 YqjK-like protein; Region: YqjK; pfam13997 655817010224 Predicted membrane protein [Function unknown]; Region: COG2259 655817010225 Predicted membrane protein [Function unknown]; Region: COG2259 655817010226 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 655817010227 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 655817010228 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 655817010229 putative dimer interface [polypeptide binding]; other site 655817010230 N-terminal domain interface [polypeptide binding]; other site 655817010231 putative substrate binding pocket (H-site) [chemical binding]; other site 655817010232 Predicted membrane protein [Function unknown]; Region: COG3152 655817010233 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817010234 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 655817010235 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655817010236 dimerization interface [polypeptide binding]; other site 655817010237 Pirin-related protein [General function prediction only]; Region: COG1741 655817010238 Pirin; Region: Pirin; pfam02678 655817010239 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 655817010240 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 655817010241 serine transporter; Region: stp; TIGR00814 655817010242 L-serine dehydratase TdcG; Provisional; Region: PRK15040 655817010243 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 655817010244 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 655817010245 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 655817010246 homotrimer interaction site [polypeptide binding]; other site 655817010247 putative active site [active] 655817010248 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 655817010249 Pyruvate formate lyase 1; Region: PFL1; cd01678 655817010250 coenzyme A binding site [chemical binding]; other site 655817010251 active site 655817010252 catalytic residues [active] 655817010253 glycine loop; other site 655817010254 propionate/acetate kinase; Provisional; Region: PRK12379 655817010255 Acetokinase family; Region: Acetate_kinase; cl17229 655817010256 threonine/serine transporter TdcC; Provisional; Region: PRK13629 655817010257 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 655817010258 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 655817010259 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 655817010260 tetramer interface [polypeptide binding]; other site 655817010261 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817010262 catalytic residue [active] 655817010263 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 655817010264 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817010265 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 655817010266 putative substrate binding pocket [chemical binding]; other site 655817010267 putative dimerization interface [polypeptide binding]; other site 655817010268 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 655817010269 glycerate kinase I; Provisional; Region: PRK10342 655817010270 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 655817010271 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 655817010272 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 655817010273 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817010274 D-galactonate transporter; Region: 2A0114; TIGR00893 655817010275 putative substrate translocation pore; other site 655817010276 galactarate dehydratase; Region: galactar-dH20; TIGR03248 655817010277 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 655817010278 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 655817010279 putative regulator PrlF; Provisional; Region: PRK09974 655817010280 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 655817010281 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 655817010282 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 655817010283 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 655817010284 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817010285 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 655817010286 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 655817010287 active site 655817010288 phosphorylation site [posttranslational modification] 655817010289 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 655817010290 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 655817010291 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 655817010292 active pocket/dimerization site; other site 655817010293 active site 655817010294 phosphorylation site [posttranslational modification] 655817010295 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 655817010296 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 655817010297 active site 655817010298 dimer interface [polypeptide binding]; other site 655817010299 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 655817010300 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 655817010301 dimer interface [polypeptide binding]; other site 655817010302 active site 655817010303 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 655817010304 putative active site [active] 655817010305 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 655817010306 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 655817010307 active site 655817010308 intersubunit interface [polypeptide binding]; other site 655817010309 zinc binding site [ion binding]; other site 655817010310 Na+ binding site [ion binding]; other site 655817010311 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 655817010312 active site 655817010313 phosphorylation site [posttranslational modification] 655817010314 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 655817010315 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 655817010316 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 655817010317 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 655817010318 active site 655817010319 trimer interface [polypeptide binding]; other site 655817010320 allosteric site; other site 655817010321 active site lid [active] 655817010322 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 655817010323 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 655817010324 putative SAM binding site [chemical binding]; other site 655817010325 putative homodimer interface [polypeptide binding]; other site 655817010326 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 655817010327 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 655817010328 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 655817010329 putative ligand binding site [chemical binding]; other site 655817010330 TIGR00252 family protein; Region: TIGR00252 655817010331 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 655817010332 dimer interface [polypeptide binding]; other site 655817010333 active site 655817010334 outer membrane lipoprotein; Provisional; Region: PRK11023 655817010335 BON domain; Region: BON; pfam04972 655817010336 BON domain; Region: BON; pfam04972 655817010337 Predicted permease; Region: DUF318; pfam03773 655817010338 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 655817010339 NADH(P)-binding; Region: NAD_binding_10; pfam13460 655817010340 NAD binding site [chemical binding]; other site 655817010341 active site 655817010342 hypothetical protein; Provisional; Region: PRK03467 655817010343 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 655817010344 GIY-YIG motif/motif A; other site 655817010345 putative active site [active] 655817010346 putative metal binding site [ion binding]; other site 655817010347 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 655817010348 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655817010349 Coenzyme A binding pocket [chemical binding]; other site 655817010350 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 655817010351 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 655817010352 Peptidase family U32; Region: Peptidase_U32; pfam01136 655817010353 putative protease; Provisional; Region: PRK15447 655817010354 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 655817010355 hypothetical protein; Provisional; Region: PRK10508 655817010356 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 655817010357 tryptophan permease; Provisional; Region: PRK10483 655817010358 aromatic amino acid transport protein; Region: araaP; TIGR00837 655817010359 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 655817010360 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 655817010361 ATP binding site [chemical binding]; other site 655817010362 Mg++ binding site [ion binding]; other site 655817010363 motif III; other site 655817010364 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817010365 nucleotide binding region [chemical binding]; other site 655817010366 ATP-binding site [chemical binding]; other site 655817010367 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 655817010368 putative RNA binding site [nucleotide binding]; other site 655817010369 lipoprotein NlpI; Provisional; Region: PRK11189 655817010370 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655817010371 binding surface 655817010372 TPR motif; other site 655817010373 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 655817010374 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 655817010375 RNase E interface [polypeptide binding]; other site 655817010376 trimer interface [polypeptide binding]; other site 655817010377 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 655817010378 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 655817010379 RNase E interface [polypeptide binding]; other site 655817010380 trimer interface [polypeptide binding]; other site 655817010381 active site 655817010382 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 655817010383 putative nucleic acid binding region [nucleotide binding]; other site 655817010384 G-X-X-G motif; other site 655817010385 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 655817010386 RNA binding site [nucleotide binding]; other site 655817010387 domain interface; other site 655817010388 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 655817010389 16S/18S rRNA binding site [nucleotide binding]; other site 655817010390 S13e-L30e interaction site [polypeptide binding]; other site 655817010391 25S rRNA binding site [nucleotide binding]; other site 655817010392 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 655817010393 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 655817010394 RNA binding site [nucleotide binding]; other site 655817010395 active site 655817010396 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 655817010397 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 655817010398 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 655817010399 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 655817010400 translation initiation factor IF-2; Region: IF-2; TIGR00487 655817010401 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 655817010402 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 655817010403 G1 box; other site 655817010404 putative GEF interaction site [polypeptide binding]; other site 655817010405 GTP/Mg2+ binding site [chemical binding]; other site 655817010406 Switch I region; other site 655817010407 G2 box; other site 655817010408 G3 box; other site 655817010409 Switch II region; other site 655817010410 G4 box; other site 655817010411 G5 box; other site 655817010412 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 655817010413 Translation-initiation factor 2; Region: IF-2; pfam11987 655817010414 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 655817010415 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 655817010416 NusA N-terminal domain; Region: NusA_N; pfam08529 655817010417 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 655817010418 RNA binding site [nucleotide binding]; other site 655817010419 homodimer interface [polypeptide binding]; other site 655817010420 NusA-like KH domain; Region: KH_5; pfam13184 655817010421 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 655817010422 G-X-X-G motif; other site 655817010423 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 655817010424 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 655817010425 ribosome maturation protein RimP; Reviewed; Region: PRK00092 655817010426 Sm and related proteins; Region: Sm_like; cl00259 655817010427 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 655817010428 putative oligomer interface [polypeptide binding]; other site 655817010429 putative RNA binding site [nucleotide binding]; other site 655817010430 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 655817010431 ANP binding site [chemical binding]; other site 655817010432 Substrate Binding Site II [chemical binding]; other site 655817010433 Substrate Binding Site I [chemical binding]; other site 655817010434 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 655817010435 Sulfatase; Region: Sulfatase; pfam00884 655817010436 Preprotein translocase SecG subunit; Region: SecG; pfam03840 655817010437 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 655817010438 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 655817010439 active site 655817010440 substrate binding site [chemical binding]; other site 655817010441 metal binding site [ion binding]; metal-binding site 655817010442 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 655817010443 dihydropteroate synthase; Region: DHPS; TIGR01496 655817010444 substrate binding pocket [chemical binding]; other site 655817010445 dimer interface [polypeptide binding]; other site 655817010446 inhibitor binding site; inhibition site 655817010447 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 655817010448 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817010449 Walker A motif; other site 655817010450 ATP binding site [chemical binding]; other site 655817010451 Walker B motif; other site 655817010452 arginine finger; other site 655817010453 Peptidase family M41; Region: Peptidase_M41; pfam01434 655817010454 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 655817010455 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817010456 S-adenosylmethionine binding site [chemical binding]; other site 655817010457 RNA-binding protein YhbY; Provisional; Region: PRK10343 655817010458 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 655817010459 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 655817010460 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 655817010461 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 655817010462 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 655817010463 GTPase CgtA; Reviewed; Region: obgE; PRK12298 655817010464 GTP1/OBG; Region: GTP1_OBG; pfam01018 655817010465 Obg GTPase; Region: Obg; cd01898 655817010466 G1 box; other site 655817010467 GTP/Mg2+ binding site [chemical binding]; other site 655817010468 Switch I region; other site 655817010469 G2 box; other site 655817010470 G3 box; other site 655817010471 Switch II region; other site 655817010472 G4 box; other site 655817010473 G5 box; other site 655817010474 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 655817010475 EamA-like transporter family; Region: EamA; pfam00892 655817010476 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 655817010477 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 655817010478 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 655817010479 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 655817010480 substrate binding pocket [chemical binding]; other site 655817010481 chain length determination region; other site 655817010482 substrate-Mg2+ binding site; other site 655817010483 catalytic residues [active] 655817010484 aspartate-rich region 1; other site 655817010485 active site lid residues [active] 655817010486 aspartate-rich region 2; other site 655817010487 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 655817010488 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 655817010489 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 655817010490 hinge; other site 655817010491 active site 655817010492 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 655817010493 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 655817010494 anti sigma factor interaction site; other site 655817010495 regulatory phosphorylation site [posttranslational modification]; other site 655817010496 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 655817010497 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 655817010498 mce related protein; Region: MCE; pfam02470 655817010499 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 655817010500 conserved hypothetical integral membrane protein; Region: TIGR00056 655817010501 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 655817010502 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 655817010503 Walker A/P-loop; other site 655817010504 ATP binding site [chemical binding]; other site 655817010505 Q-loop/lid; other site 655817010506 ABC transporter signature motif; other site 655817010507 Walker B; other site 655817010508 D-loop; other site 655817010509 H-loop/switch region; other site 655817010510 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 655817010511 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 655817010512 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 655817010513 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 655817010514 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 655817010515 putative active site [active] 655817010516 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 655817010517 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 655817010518 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 655817010519 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 655817010520 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 655817010521 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 655817010522 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 655817010523 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 655817010524 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 655817010525 Walker A/P-loop; other site 655817010526 ATP binding site [chemical binding]; other site 655817010527 Q-loop/lid; other site 655817010528 ABC transporter signature motif; other site 655817010529 Walker B; other site 655817010530 D-loop; other site 655817010531 H-loop/switch region; other site 655817010532 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 655817010533 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 655817010534 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 655817010535 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 655817010536 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 655817010537 30S subunit binding site; other site 655817010538 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655817010539 active site 655817010540 phosphorylation site [posttranslational modification] 655817010541 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 655817010542 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 655817010543 dimerization domain swap beta strand [polypeptide binding]; other site 655817010544 regulatory protein interface [polypeptide binding]; other site 655817010545 active site 655817010546 regulatory phosphorylation site [posttranslational modification]; other site 655817010547 hypothetical protein; Provisional; Region: PRK10345 655817010548 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 655817010549 Transglycosylase; Region: Transgly; cl17702 655817010550 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 655817010551 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 655817010552 conserved cys residue [active] 655817010553 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 655817010554 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655817010555 putative active site [active] 655817010556 heme pocket [chemical binding]; other site 655817010557 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817010558 dimer interface [polypeptide binding]; other site 655817010559 phosphorylation site [posttranslational modification] 655817010560 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817010561 ATP binding site [chemical binding]; other site 655817010562 Mg2+ binding site [ion binding]; other site 655817010563 G-X-G motif; other site 655817010564 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817010565 active site 655817010566 phosphorylation site [posttranslational modification] 655817010567 intermolecular recognition site; other site 655817010568 dimerization interface [polypeptide binding]; other site 655817010569 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 655817010570 putative binding surface; other site 655817010571 active site 655817010572 radical SAM protein, TIGR01212 family; Region: TIGR01212 655817010573 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817010574 FeS/SAM binding site; other site 655817010575 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 655817010576 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 655817010577 active site 655817010578 dimer interface [polypeptide binding]; other site 655817010579 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 655817010580 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 655817010581 active site 655817010582 FMN binding site [chemical binding]; other site 655817010583 substrate binding site [chemical binding]; other site 655817010584 3Fe-4S cluster binding site [ion binding]; other site 655817010585 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 655817010586 domain interface; other site 655817010587 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 655817010588 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655817010589 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817010590 Domain of unknown function (DUF386); Region: DUF386; cl01047 655817010591 N-acetylmannosamine kinase; Provisional; Region: PRK05082 655817010592 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655817010593 nucleotide binding site [chemical binding]; other site 655817010594 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 655817010595 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 655817010596 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 655817010597 putative active site cavity [active] 655817010598 putative sialic acid transporter; Provisional; Region: PRK03893 655817010599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817010600 putative substrate translocation pore; other site 655817010601 N-acetylneuraminate lyase; Region: nanA; TIGR00683 655817010602 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 655817010603 inhibitor site; inhibition site 655817010604 active site 655817010605 dimer interface [polypeptide binding]; other site 655817010606 catalytic residue [active] 655817010607 transcriptional regulator NanR; Provisional; Region: PRK03837 655817010608 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817010609 DNA-binding site [nucleotide binding]; DNA binding site 655817010610 FCD domain; Region: FCD; pfam07729 655817010611 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 655817010612 stringent starvation protein A; Provisional; Region: sspA; PRK09481 655817010613 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 655817010614 C-terminal domain interface [polypeptide binding]; other site 655817010615 putative GSH binding site (G-site) [chemical binding]; other site 655817010616 dimer interface [polypeptide binding]; other site 655817010617 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 655817010618 dimer interface [polypeptide binding]; other site 655817010619 N-terminal domain interface [polypeptide binding]; other site 655817010620 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 655817010621 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 655817010622 23S rRNA interface [nucleotide binding]; other site 655817010623 L3 interface [polypeptide binding]; other site 655817010624 Predicted ATPase [General function prediction only]; Region: COG1485 655817010625 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 655817010626 hypothetical protein; Provisional; Region: PRK11677 655817010627 serine endoprotease; Provisional; Region: PRK10139 655817010628 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 655817010629 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655817010630 protein binding site [polypeptide binding]; other site 655817010631 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655817010632 serine endoprotease; Provisional; Region: PRK10898 655817010633 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 655817010634 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 655817010635 malate dehydrogenase; Provisional; Region: PRK05086 655817010636 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 655817010637 NAD binding site [chemical binding]; other site 655817010638 dimerization interface [polypeptide binding]; other site 655817010639 Substrate binding site [chemical binding]; other site 655817010640 arginine repressor; Provisional; Region: PRK05066 655817010641 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 655817010642 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 655817010643 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 655817010644 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 655817010645 RNAase interaction site [polypeptide binding]; other site 655817010646 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 655817010647 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 655817010648 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 655817010649 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817010650 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817010651 efflux system membrane protein; Provisional; Region: PRK11594 655817010652 transcriptional regulator; Provisional; Region: PRK10632 655817010653 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817010654 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 655817010655 putative effector binding pocket; other site 655817010656 dimerization interface [polypeptide binding]; other site 655817010657 protease TldD; Provisional; Region: tldD; PRK10735 655817010658 hypothetical protein; Provisional; Region: PRK10899 655817010659 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 655817010660 ribonuclease G; Provisional; Region: PRK11712 655817010661 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 655817010662 homodimer interface [polypeptide binding]; other site 655817010663 oligonucleotide binding site [chemical binding]; other site 655817010664 Maf-like protein; Region: Maf; pfam02545 655817010665 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 655817010666 active site 655817010667 dimer interface [polypeptide binding]; other site 655817010668 rod shape-determining protein MreD; Provisional; Region: PRK11060 655817010669 rod shape-determining protein MreC; Region: mreC; TIGR00219 655817010670 rod shape-determining protein MreC; Region: MreC; pfam04085 655817010671 rod shape-determining protein MreB; Provisional; Region: PRK13927 655817010672 MreB and similar proteins; Region: MreB_like; cd10225 655817010673 nucleotide binding site [chemical binding]; other site 655817010674 Mg binding site [ion binding]; other site 655817010675 putative protofilament interaction site [polypeptide binding]; other site 655817010676 RodZ interaction site [polypeptide binding]; other site 655817010677 regulatory protein CsrD; Provisional; Region: PRK11059 655817010678 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817010679 metal binding site [ion binding]; metal-binding site 655817010680 active site 655817010681 I-site; other site 655817010682 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817010683 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 655817010684 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 655817010685 NADP binding site [chemical binding]; other site 655817010686 dimer interface [polypeptide binding]; other site 655817010687 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 655817010688 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 655817010689 carboxyltransferase (CT) interaction site; other site 655817010690 biotinylation site [posttranslational modification]; other site 655817010691 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 655817010692 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 655817010693 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 655817010694 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 655817010695 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 655817010696 active site 655817010697 catalytic residues [active] 655817010698 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655817010699 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 655817010700 substrate binding site [chemical binding]; other site 655817010701 ATP binding site [chemical binding]; other site 655817010702 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 655817010703 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 655817010704 TM-ABC transporter signature motif; other site 655817010705 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 655817010706 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 655817010707 Walker A/P-loop; other site 655817010708 ATP binding site [chemical binding]; other site 655817010709 Q-loop/lid; other site 655817010710 ABC transporter signature motif; other site 655817010711 Walker B; other site 655817010712 D-loop; other site 655817010713 H-loop/switch region; other site 655817010714 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 655817010715 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 655817010716 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 655817010717 putative ligand binding site [chemical binding]; other site 655817010718 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 655817010719 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 655817010720 intersubunit interface [polypeptide binding]; other site 655817010721 active site 655817010722 zinc binding site [ion binding]; other site 655817010723 Na+ binding site [ion binding]; other site 655817010724 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655817010725 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 655817010726 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817010727 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655817010728 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 655817010729 substrate binding site [chemical binding]; other site 655817010730 ATP binding site [chemical binding]; other site 655817010731 hypothetical protein; Provisional; Region: PRK10633 655817010732 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 655817010733 Na binding site [ion binding]; other site 655817010734 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 655817010735 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 655817010736 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 655817010737 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 655817010738 FMN binding site [chemical binding]; other site 655817010739 active site 655817010740 catalytic residues [active] 655817010741 substrate binding site [chemical binding]; other site 655817010742 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 655817010743 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 655817010744 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 655817010745 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817010746 DNA methylase; Region: N6_N4_Mtase; pfam01555 655817010747 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 655817010748 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 655817010749 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817010750 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 655817010751 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 655817010752 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817010753 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817010754 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 655817010755 Protein export membrane protein; Region: SecD_SecF; cl14618 655817010756 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 655817010757 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 655817010758 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817010759 substrate binding pocket [chemical binding]; other site 655817010760 membrane-bound complex binding site; other site 655817010761 hinge residues; other site 655817010762 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 655817010763 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817010764 conserved gate region; other site 655817010765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817010766 dimer interface [polypeptide binding]; other site 655817010767 conserved gate region; other site 655817010768 putative PBP binding loops; other site 655817010769 ABC-ATPase subunit interface; other site 655817010770 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 655817010771 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817010772 dimer interface [polypeptide binding]; other site 655817010773 conserved gate region; other site 655817010774 putative PBP binding loops; other site 655817010775 ABC-ATPase subunit interface; other site 655817010776 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 655817010777 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 655817010778 Walker A/P-loop; other site 655817010779 ATP binding site [chemical binding]; other site 655817010780 Q-loop/lid; other site 655817010781 ABC transporter signature motif; other site 655817010782 Walker B; other site 655817010783 D-loop; other site 655817010784 H-loop/switch region; other site 655817010785 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 655817010786 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 655817010787 trimer interface [polypeptide binding]; other site 655817010788 putative metal binding site [ion binding]; other site 655817010789 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 655817010790 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 655817010791 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 655817010792 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 655817010793 shikimate binding site; other site 655817010794 NAD(P) binding site [chemical binding]; other site 655817010795 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 655817010796 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 655817010797 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 655817010798 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 655817010799 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 655817010800 hypothetical protein; Validated; Region: PRK03430 655817010801 hypothetical protein; Provisional; Region: PRK10736 655817010802 DNA protecting protein DprA; Region: dprA; TIGR00732 655817010803 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 655817010804 active site 655817010805 catalytic residues [active] 655817010806 metal binding site [ion binding]; metal-binding site 655817010807 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 655817010808 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 655817010809 putative active site [active] 655817010810 substrate binding site [chemical binding]; other site 655817010811 putative cosubstrate binding site; other site 655817010812 catalytic site [active] 655817010813 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 655817010814 substrate binding site [chemical binding]; other site 655817010815 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 655817010816 putative RNA binding site [nucleotide binding]; other site 655817010817 16S rRNA methyltransferase B; Provisional; Region: PRK10901 655817010818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817010819 S-adenosylmethionine binding site [chemical binding]; other site 655817010820 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 655817010821 TrkA-N domain; Region: TrkA_N; pfam02254 655817010822 TrkA-C domain; Region: TrkA_C; pfam02080 655817010823 TrkA-N domain; Region: TrkA_N; pfam02254 655817010824 TrkA-C domain; Region: TrkA_C; pfam02080 655817010825 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 655817010826 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 655817010827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 655817010828 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 655817010829 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 655817010830 DNA binding residues [nucleotide binding] 655817010831 dimer interface [polypeptide binding]; other site 655817010832 metal binding site [ion binding]; metal-binding site 655817010833 hypothetical protein; Provisional; Region: PRK10203 655817010834 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 655817010835 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 655817010836 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 655817010837 alphaNTD homodimer interface [polypeptide binding]; other site 655817010838 alphaNTD - beta interaction site [polypeptide binding]; other site 655817010839 alphaNTD - beta' interaction site [polypeptide binding]; other site 655817010840 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 655817010841 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 655817010842 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 655817010843 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655817010844 RNA binding surface [nucleotide binding]; other site 655817010845 30S ribosomal protein S11; Validated; Region: PRK05309 655817010846 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 655817010847 30S ribosomal protein S13; Region: bact_S13; TIGR03631 655817010848 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 655817010849 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 655817010850 SecY translocase; Region: SecY; pfam00344 655817010851 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 655817010852 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 655817010853 23S rRNA binding site [nucleotide binding]; other site 655817010854 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 655817010855 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 655817010856 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 655817010857 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 655817010858 23S rRNA interface [nucleotide binding]; other site 655817010859 5S rRNA interface [nucleotide binding]; other site 655817010860 L27 interface [polypeptide binding]; other site 655817010861 L5 interface [polypeptide binding]; other site 655817010862 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 655817010863 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 655817010864 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 655817010865 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 655817010866 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 655817010867 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 655817010868 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 655817010869 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 655817010870 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 655817010871 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 655817010872 RNA binding site [nucleotide binding]; other site 655817010873 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 655817010874 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 655817010875 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 655817010876 23S rRNA interface [nucleotide binding]; other site 655817010877 putative translocon interaction site; other site 655817010878 signal recognition particle (SRP54) interaction site; other site 655817010879 L23 interface [polypeptide binding]; other site 655817010880 trigger factor interaction site; other site 655817010881 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 655817010882 23S rRNA interface [nucleotide binding]; other site 655817010883 5S rRNA interface [nucleotide binding]; other site 655817010884 putative antibiotic binding site [chemical binding]; other site 655817010885 L25 interface [polypeptide binding]; other site 655817010886 L27 interface [polypeptide binding]; other site 655817010887 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 655817010888 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 655817010889 G-X-X-G motif; other site 655817010890 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 655817010891 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 655817010892 protein-rRNA interface [nucleotide binding]; other site 655817010893 putative translocon binding site; other site 655817010894 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 655817010895 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 655817010896 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 655817010897 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 655817010898 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 655817010899 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 655817010900 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 655817010901 protein secretion protein GspB; Provisional; Region: PRK09697 655817010902 AAA domain; Region: AAA_22; pfam13401 655817010903 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 655817010904 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 655817010905 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 655817010906 type II secretion system protein D; Region: type_II_gspD; TIGR02517 655817010907 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 655817010908 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 655817010909 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 655817010910 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 655817010911 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 655817010912 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 655817010913 Walker A motif; other site 655817010914 ATP binding site [chemical binding]; other site 655817010915 Walker B motif; other site 655817010916 type II secretion system protein F; Region: GspF; TIGR02120 655817010917 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 655817010918 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 655817010919 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 655817010920 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 655817010921 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 655817010922 Type II transport protein GspH; Region: GspH; pfam12019 655817010923 type II secretion system protein I; Region: gspI; TIGR01707 655817010924 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 655817010925 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 655817010926 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 655817010927 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 655817010928 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 655817010929 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 655817010930 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 655817010931 GspL periplasmic domain; Region: GspL_C; pfam12693 655817010932 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 655817010933 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 655817010934 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 655817010935 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 655817010936 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 655817010937 heme binding site [chemical binding]; other site 655817010938 ferroxidase pore; other site 655817010939 ferroxidase diiron center [ion binding]; other site 655817010940 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 655817010941 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 655817010942 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 655817010943 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 655817010944 aromatic chitin/cellulose binding site residues [chemical binding]; other site 655817010945 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 655817010946 active site 655817010947 elongation factor Tu; Reviewed; Region: PRK00049 655817010948 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 655817010949 G1 box; other site 655817010950 GEF interaction site [polypeptide binding]; other site 655817010951 GTP/Mg2+ binding site [chemical binding]; other site 655817010952 Switch I region; other site 655817010953 G2 box; other site 655817010954 G3 box; other site 655817010955 Switch II region; other site 655817010956 G4 box; other site 655817010957 G5 box; other site 655817010958 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 655817010959 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 655817010960 Antibiotic Binding Site [chemical binding]; other site 655817010961 elongation factor G; Reviewed; Region: PRK00007 655817010962 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 655817010963 G1 box; other site 655817010964 putative GEF interaction site [polypeptide binding]; other site 655817010965 GTP/Mg2+ binding site [chemical binding]; other site 655817010966 Switch I region; other site 655817010967 G2 box; other site 655817010968 G3 box; other site 655817010969 Switch II region; other site 655817010970 G4 box; other site 655817010971 G5 box; other site 655817010972 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 655817010973 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 655817010974 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 655817010975 30S ribosomal protein S7; Validated; Region: PRK05302 655817010976 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 655817010977 S17 interaction site [polypeptide binding]; other site 655817010978 S8 interaction site; other site 655817010979 16S rRNA interaction site [nucleotide binding]; other site 655817010980 streptomycin interaction site [chemical binding]; other site 655817010981 23S rRNA interaction site [nucleotide binding]; other site 655817010982 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 655817010983 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 655817010984 sulfur relay protein TusC; Validated; Region: PRK00211 655817010985 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 655817010986 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 655817010987 YheO-like PAS domain; Region: PAS_6; pfam08348 655817010988 HTH domain; Region: HTH_22; pfam13309 655817010989 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 655817010990 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 655817010991 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 655817010992 phi X174 lysis protein; Provisional; Region: PRK02793 655817010993 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 655817010994 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 655817010995 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 655817010996 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 655817010997 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 655817010998 TrkA-N domain; Region: TrkA_N; pfam02254 655817010999 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 655817011000 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 655817011001 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817011002 Walker A/P-loop; other site 655817011003 ATP binding site [chemical binding]; other site 655817011004 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655817011005 ABC transporter signature motif; other site 655817011006 Walker B; other site 655817011007 D-loop; other site 655817011008 ABC transporter; Region: ABC_tran_2; pfam12848 655817011009 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655817011010 putative hydrolase; Provisional; Region: PRK10985 655817011011 hypothetical protein; Provisional; Region: PRK04966 655817011012 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 655817011013 active site 655817011014 hypothetical protein; Provisional; Region: PRK10738 655817011015 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 655817011016 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 655817011017 ligand binding site [chemical binding]; other site 655817011018 flexible hinge region; other site 655817011019 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 655817011020 putative switch regulator; other site 655817011021 non-specific DNA interactions [nucleotide binding]; other site 655817011022 DNA binding site [nucleotide binding] 655817011023 sequence specific DNA binding site [nucleotide binding]; other site 655817011024 putative cAMP binding site [chemical binding]; other site 655817011025 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 655817011026 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 655817011027 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 655817011028 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 655817011029 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 655817011030 inhibitor-cofactor binding pocket; inhibition site 655817011031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817011032 catalytic residue [active] 655817011033 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 655817011034 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 655817011035 glutamine binding [chemical binding]; other site 655817011036 catalytic triad [active] 655817011037 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 655817011038 cell filamentation protein Fic; Provisional; Region: PRK10347 655817011039 hypothetical protein; Provisional; Region: PRK10204 655817011040 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 655817011041 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 655817011042 substrate binding site [chemical binding]; other site 655817011043 putative transporter; Provisional; Region: PRK03699 655817011044 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817011045 putative substrate translocation pore; other site 655817011046 nitrite reductase subunit NirD; Provisional; Region: PRK14989 655817011047 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817011048 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 655817011049 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 655817011050 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 655817011051 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 655817011052 nitrite transporter NirC; Provisional; Region: PRK11562 655817011053 siroheme synthase; Provisional; Region: cysG; PRK10637 655817011054 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 655817011055 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 655817011056 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 655817011057 active site 655817011058 SAM binding site [chemical binding]; other site 655817011059 homodimer interface [polypeptide binding]; other site 655817011060 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 655817011061 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 655817011062 Protein of unknown function; Region: YhfT; pfam10797 655817011063 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 655817011064 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 655817011065 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 655817011066 active site 655817011067 substrate binding pocket [chemical binding]; other site 655817011068 homodimer interaction site [polypeptide binding]; other site 655817011069 putative mutase; Provisional; Region: PRK12383 655817011070 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 655817011071 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 655817011072 dimer interface [polypeptide binding]; other site 655817011073 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 655817011074 active site 655817011075 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 655817011076 substrate binding site [chemical binding]; other site 655817011077 catalytic residue [active] 655817011078 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 655817011079 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 655817011080 active site 655817011081 HIGH motif; other site 655817011082 dimer interface [polypeptide binding]; other site 655817011083 KMSKS motif; other site 655817011084 phosphoglycolate phosphatase; Provisional; Region: PRK13222 655817011085 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817011086 motif II; other site 655817011087 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 655817011088 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 655817011089 substrate binding site [chemical binding]; other site 655817011090 hexamer interface [polypeptide binding]; other site 655817011091 metal binding site [ion binding]; metal-binding site 655817011092 DNA adenine methylase; Provisional; Region: PRK10904 655817011093 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 655817011094 cell division protein DamX; Validated; Region: PRK10905 655817011095 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 655817011096 active site 655817011097 dimer interface [polypeptide binding]; other site 655817011098 metal binding site [ion binding]; metal-binding site 655817011099 shikimate kinase; Reviewed; Region: aroK; PRK00131 655817011100 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 655817011101 ADP binding site [chemical binding]; other site 655817011102 magnesium binding site [ion binding]; other site 655817011103 putative shikimate binding site; other site 655817011104 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 655817011105 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 655817011106 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 655817011107 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 655817011108 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 655817011109 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 655817011110 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 655817011111 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 655817011112 Transglycosylase; Region: Transgly; pfam00912 655817011113 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 655817011114 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 655817011115 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 655817011116 ADP-ribose binding site [chemical binding]; other site 655817011117 dimer interface [polypeptide binding]; other site 655817011118 active site 655817011119 nudix motif; other site 655817011120 metal binding site [ion binding]; metal-binding site 655817011121 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 655817011122 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 655817011123 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817011124 motif II; other site 655817011125 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655817011126 RNA binding surface [nucleotide binding]; other site 655817011127 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 655817011128 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 655817011129 dimerization interface [polypeptide binding]; other site 655817011130 domain crossover interface; other site 655817011131 redox-dependent activation switch; other site 655817011132 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 655817011133 Glycosyl hydrolase family 81; Region: Glyco_hydro_81; cl02310 655817011134 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 655817011135 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 655817011136 active site 655817011137 substrate-binding site [chemical binding]; other site 655817011138 metal-binding site [ion binding] 655817011139 ATP binding site [chemical binding]; other site 655817011140 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 655817011141 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655817011142 non-specific DNA binding site [nucleotide binding]; other site 655817011143 salt bridge; other site 655817011144 sequence-specific DNA binding site [nucleotide binding]; other site 655817011145 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 655817011146 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655817011147 dimerization interface [polypeptide binding]; other site 655817011148 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817011149 dimer interface [polypeptide binding]; other site 655817011150 phosphorylation site [posttranslational modification] 655817011151 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817011152 ATP binding site [chemical binding]; other site 655817011153 G-X-G motif; other site 655817011154 osmolarity response regulator; Provisional; Region: ompR; PRK09468 655817011155 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817011156 active site 655817011157 phosphorylation site [posttranslational modification] 655817011158 intermolecular recognition site; other site 655817011159 dimerization interface [polypeptide binding]; other site 655817011160 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817011161 DNA binding site [nucleotide binding] 655817011162 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 655817011163 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 655817011164 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 655817011165 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 655817011166 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 655817011167 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 655817011168 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 655817011169 RNA binding site [nucleotide binding]; other site 655817011170 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 655817011171 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 655817011172 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 655817011173 G1 box; other site 655817011174 GTP/Mg2+ binding site [chemical binding]; other site 655817011175 Switch I region; other site 655817011176 G2 box; other site 655817011177 G3 box; other site 655817011178 Switch II region; other site 655817011179 G4 box; other site 655817011180 G5 box; other site 655817011181 Nucleoside recognition; Region: Gate; pfam07670 655817011182 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 655817011183 Nucleoside recognition; Region: Gate; pfam07670 655817011184 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 655817011185 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 655817011186 carboxylesterase BioH; Provisional; Region: PRK10349 655817011187 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 655817011188 DNA utilization protein GntX; Provisional; Region: PRK11595 655817011189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655817011190 active site 655817011191 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 655817011192 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 655817011193 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 655817011194 high-affinity gluconate transporter; Provisional; Region: PRK14984 655817011195 gluconate transporter; Region: gntP; TIGR00791 655817011196 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 655817011197 4-alpha-glucanotransferase; Region: Glyco_hydro_77; cl00711 655817011198 maltodextrin phosphorylase; Provisional; Region: PRK14985 655817011199 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 655817011200 homodimer interface [polypeptide binding]; other site 655817011201 active site pocket [active] 655817011202 transcriptional regulator MalT; Provisional; Region: PRK04841 655817011203 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817011204 DNA binding residues [nucleotide binding] 655817011205 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 655817011206 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 655817011207 putative active site [active] 655817011208 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 655817011209 hypothetical protein; Reviewed; Region: PRK09588 655817011210 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 655817011211 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 655817011212 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817011213 Walker A motif; other site 655817011214 ATP binding site [chemical binding]; other site 655817011215 Walker B motif; other site 655817011216 arginine finger; other site 655817011217 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 655817011218 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 655817011219 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817011220 intramembrane serine protease GlpG; Provisional; Region: PRK10907 655817011221 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 655817011222 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 655817011223 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 655817011224 active site residue [active] 655817011225 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 655817011226 hypothetical protein; Provisional; Region: PRK09781; cl08057 655817011227 Fimbrial protein; Region: Fimbrial; cl01416 655817011228 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 655817011229 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 655817011230 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 655817011231 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817011232 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817011233 outer membrane usher protein; Provisional; Region: PRK15193 655817011234 PapC N-terminal domain; Region: PapC_N; pfam13954 655817011235 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 655817011236 PapC C-terminal domain; Region: PapC_C; pfam13953 655817011237 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 655817011238 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 655817011239 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 655817011240 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817011241 glycogen phosphorylase; Provisional; Region: PRK14986 655817011242 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 655817011243 homodimer interface [polypeptide binding]; other site 655817011244 active site pocket [active] 655817011245 glycogen synthase; Provisional; Region: glgA; PRK00654 655817011246 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 655817011247 ADP-binding pocket [chemical binding]; other site 655817011248 homodimer interface [polypeptide binding]; other site 655817011249 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 655817011250 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 655817011251 ligand binding site; other site 655817011252 oligomer interface; other site 655817011253 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 655817011254 sulfate 1 binding site; other site 655817011255 glycogen debranching enzyme; Provisional; Region: PRK03705 655817011256 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 655817011257 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 655817011258 active site 655817011259 catalytic site [active] 655817011260 glycogen branching enzyme; Provisional; Region: PRK05402 655817011261 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 655817011262 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 655817011263 active site 655817011264 catalytic site [active] 655817011265 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 655817011266 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 655817011267 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 655817011268 putative antibiotic transporter; Provisional; Region: PRK10739 655817011269 Predicted Rossmann fold nucleotide-binding protein involved in DNA uptake [DNA replication, recombination, and repair / Intracellular trafficking and secretion]; Region: Smf; COG0758 655817011270 DNA protecting protein DprA; Region: dprA; TIGR00732 655817011271 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 655817011272 non-specific DNA interactions [nucleotide binding]; other site 655817011273 DNA binding site [nucleotide binding] 655817011274 sequence specific DNA binding site [nucleotide binding]; other site 655817011275 putative cAMP binding site [chemical binding]; other site 655817011276 Superfamily II DNA helicase [DNA replication, recombination, and repair]; Region: RecQ; COG0514 655817011277 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655817011278 ATP binding site [chemical binding]; other site 655817011279 putative Mg++ binding site [ion binding]; other site 655817011280 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817011281 nucleotide binding region [chemical binding]; other site 655817011282 ATP-binding site [chemical binding]; other site 655817011283 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655817011284 active site 655817011285 low affinity gluconate transporter; Provisional; Region: PRK10472 655817011286 gluconate transporter; Region: gntP; TIGR00791 655817011287 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 655817011288 Shikimate kinase; Region: SKI; pfam01202 655817011289 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 655817011290 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817011291 DNA binding site [nucleotide binding] 655817011292 domain linker motif; other site 655817011293 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 655817011294 putative ligand binding site [chemical binding]; other site 655817011295 putative dimerization interface [polypeptide binding]; other site 655817011296 Pirin-related protein [General function prediction only]; Region: COG1741 655817011297 Pirin; Region: Pirin; pfam02678 655817011298 putative oxidoreductase; Provisional; Region: PRK10206 655817011299 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 655817011300 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 655817011301 potential frameshift: common BLAST hit: gi|218691729|ref|YP_002399941.1| putative acetyltransferase YhhY 655817011302 putative acetyltransferase YhhY; Provisional; Region: PRK10140 655817011303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 655817011304 Coenzyme A binding pocket [chemical binding]; other site 655817011305 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 655817011306 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 655817011307 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cl00083 655817011308 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 655817011309 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 655817011310 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 655817011311 hypothetical protein; Provisional; Region: PRK10350 655817011312 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 655817011313 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 655817011314 putative active site [active] 655817011315 catalytic site [active] 655817011316 putative metal binding site [ion binding]; other site 655817011317 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 655817011318 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 655817011319 Walker A/P-loop; other site 655817011320 ATP binding site [chemical binding]; other site 655817011321 Q-loop/lid; other site 655817011322 ABC transporter signature motif; other site 655817011323 Walker B; other site 655817011324 D-loop; other site 655817011325 H-loop/switch region; other site 655817011326 TOBE domain; Region: TOBE_2; pfam08402 655817011327 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655817011328 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817011329 dimer interface [polypeptide binding]; other site 655817011330 conserved gate region; other site 655817011331 putative PBP binding loops; other site 655817011332 ABC-ATPase subunit interface; other site 655817011333 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 655817011334 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817011335 dimer interface [polypeptide binding]; other site 655817011336 conserved gate region; other site 655817011337 putative PBP binding loops; other site 655817011338 ABC-ATPase subunit interface; other site 655817011339 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 655817011340 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 655817011341 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 655817011342 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 655817011343 Walker A/P-loop; other site 655817011344 ATP binding site [chemical binding]; other site 655817011345 Q-loop/lid; other site 655817011346 ABC transporter signature motif; other site 655817011347 Walker B; other site 655817011348 D-loop; other site 655817011349 H-loop/switch region; other site 655817011350 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 655817011351 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 655817011352 Walker A/P-loop; other site 655817011353 ATP binding site [chemical binding]; other site 655817011354 Q-loop/lid; other site 655817011355 ABC transporter signature motif; other site 655817011356 Walker B; other site 655817011357 D-loop; other site 655817011358 H-loop/switch region; other site 655817011359 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 655817011360 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 655817011361 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 655817011362 TM-ABC transporter signature motif; other site 655817011363 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 655817011364 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 655817011365 TM-ABC transporter signature motif; other site 655817011366 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 655817011367 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 655817011368 dimerization interface [polypeptide binding]; other site 655817011369 ligand binding site [chemical binding]; other site 655817011370 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 655817011371 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 655817011372 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 655817011373 dimerization interface [polypeptide binding]; other site 655817011374 ligand binding site [chemical binding]; other site 655817011375 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 655817011376 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655817011377 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655817011378 DNA binding residues [nucleotide binding] 655817011379 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 655817011380 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 655817011381 cell division protein FtsE; Provisional; Region: PRK10908 655817011382 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817011383 Walker A/P-loop; other site 655817011384 ATP binding site [chemical binding]; other site 655817011385 Q-loop/lid; other site 655817011386 ABC transporter signature motif; other site 655817011387 Walker B; other site 655817011388 D-loop; other site 655817011389 H-loop/switch region; other site 655817011390 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 655817011391 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 655817011392 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 655817011393 P loop; other site 655817011394 GTP binding site [chemical binding]; other site 655817011395 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 655817011396 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817011397 S-adenosylmethionine binding site [chemical binding]; other site 655817011398 hypothetical protein; Provisional; Region: PRK10910 655817011399 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 655817011400 Predicted membrane protein [Function unknown]; Region: COG3714 655817011401 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 655817011402 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 655817011403 metal-binding site [ion binding] 655817011404 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 655817011405 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 655817011406 CPxP motif; other site 655817011407 hypothetical protein; Provisional; Region: PRK11212 655817011408 hypothetical protein; Provisional; Region: PRK11615 655817011409 major facilitator superfamily transporter; Provisional; Region: PRK05122 655817011410 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817011411 putative substrate translocation pore; other site 655817011412 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 655817011413 Domain of unknown function DUF20; Region: UPF0118; pfam01594 655817011414 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 655817011415 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 655817011416 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 655817011417 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 655817011418 substrate binding site [chemical binding]; other site 655817011419 nickel transporter permease NikB; Provisional; Region: PRK10352 655817011420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817011421 dimer interface [polypeptide binding]; other site 655817011422 conserved gate region; other site 655817011423 putative PBP binding loops; other site 655817011424 ABC-ATPase subunit interface; other site 655817011425 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 655817011426 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817011427 dimer interface [polypeptide binding]; other site 655817011428 conserved gate region; other site 655817011429 putative PBP binding loops; other site 655817011430 ABC-ATPase subunit interface; other site 655817011431 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 655817011432 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817011433 Walker A/P-loop; other site 655817011434 ATP binding site [chemical binding]; other site 655817011435 Q-loop/lid; other site 655817011436 ABC transporter signature motif; other site 655817011437 Walker B; other site 655817011438 D-loop; other site 655817011439 H-loop/switch region; other site 655817011440 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 655817011441 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 655817011442 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817011443 Walker A/P-loop; other site 655817011444 ATP binding site [chemical binding]; other site 655817011445 Q-loop/lid; other site 655817011446 ABC transporter signature motif; other site 655817011447 Walker B; other site 655817011448 D-loop; other site 655817011449 H-loop/switch region; other site 655817011450 nickel responsive regulator; Provisional; Region: PRK02967 655817011451 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 655817011452 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 655817011453 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817011454 DNA-binding site [nucleotide binding]; DNA binding site 655817011455 UTRA domain; Region: UTRA; pfam07702 655817011456 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655817011457 active site 655817011458 phosphorylation site [posttranslational modification] 655817011459 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 655817011460 active site 655817011461 P-loop; other site 655817011462 phosphorylation site [posttranslational modification] 655817011463 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 655817011464 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 655817011465 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 655817011466 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 655817011467 putative N- and C-terminal domain interface [polypeptide binding]; other site 655817011468 putative active site [active] 655817011469 putative MgATP binding site [chemical binding]; other site 655817011470 catalytic site [active] 655817011471 metal binding site [ion binding]; metal-binding site 655817011472 putative carbohydrate binding site [chemical binding]; other site 655817011473 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 655817011474 dimerization domain swap beta strand [polypeptide binding]; other site 655817011475 regulatory protein interface [polypeptide binding]; other site 655817011476 active site 655817011477 regulatory phosphorylation site [posttranslational modification]; other site 655817011478 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 655817011479 intersubunit interface [polypeptide binding]; other site 655817011480 active site 655817011481 zinc binding site [ion binding]; other site 655817011482 Na+ binding site [ion binding]; other site 655817011483 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 655817011484 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 655817011485 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 655817011486 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 655817011487 Walker A/P-loop; other site 655817011488 ATP binding site [chemical binding]; other site 655817011489 Q-loop/lid; other site 655817011490 ABC transporter signature motif; other site 655817011491 Walker B; other site 655817011492 D-loop; other site 655817011493 H-loop/switch region; other site 655817011494 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 655817011495 Walker A/P-loop; other site 655817011496 ATP binding site [chemical binding]; other site 655817011497 Q-loop/lid; other site 655817011498 ABC transporter signature motif; other site 655817011499 Walker B; other site 655817011500 D-loop; other site 655817011501 H-loop/switch region; other site 655817011502 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 655817011503 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 655817011504 HlyD family secretion protein; Region: HlyD; pfam00529 655817011505 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817011506 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817011507 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 655817011508 Predicted flavoproteins [General function prediction only]; Region: COG2081 655817011509 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655817011510 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 655817011511 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 655817011512 universal stress protein UspB; Provisional; Region: PRK04960 655817011513 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 655817011514 Ligand Binding Site [chemical binding]; other site 655817011515 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 655817011516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817011517 POT family; Region: PTR2; pfam00854 655817011518 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817011519 S-adenosylmethionine binding site [chemical binding]; other site 655817011520 oligopeptidase A; Provisional; Region: PRK10911 655817011521 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 655817011522 active site 655817011523 Zn binding site [ion binding]; other site 655817011524 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 655817011525 glutathione reductase; Validated; Region: PRK06116 655817011526 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 655817011527 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817011528 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 655817011529 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 655817011530 ArsC family; Region: ArsC; pfam03960 655817011531 catalytic residues [active] 655817011532 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 655817011533 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655817011534 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817011535 DNA binding residues [nucleotide binding] 655817011536 dimerization interface [polypeptide binding]; other site 655817011537 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 655817011538 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 655817011539 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 655817011540 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 655817011541 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817011542 N-terminal plug; other site 655817011543 ligand-binding site [chemical binding]; other site 655817011544 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 655817011545 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 655817011546 putative hemin binding site; other site 655817011547 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 655817011548 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817011549 FeS/SAM binding site; other site 655817011550 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 655817011551 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 655817011552 NADH(P)-binding; Region: NAD_binding_10; pfam13460 655817011553 NAD(P) binding site [chemical binding]; other site 655817011554 putative active site [active] 655817011555 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 655817011556 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817011557 ABC-ATPase subunit interface; other site 655817011558 dimer interface [polypeptide binding]; other site 655817011559 putative PBP binding regions; other site 655817011560 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 655817011561 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655817011562 Walker A/P-loop; other site 655817011563 ATP binding site [chemical binding]; other site 655817011564 Q-loop/lid; other site 655817011565 ABC transporter signature motif; other site 655817011566 Walker B; other site 655817011567 D-loop; other site 655817011568 H-loop/switch region; other site 655817011569 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 655817011570 MgtC family; Region: MgtC; pfam02308 655817011571 acid-resistance protein; Provisional; Region: hdeB; PRK11566 655817011572 acid-resistance protein; Provisional; Region: PRK10208 655817011573 acid-resistance membrane protein; Provisional; Region: PRK10209 655817011574 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 655817011575 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 655817011576 pyruvate kinase; Provisional; Region: PRK05826 655817011577 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 655817011578 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817011579 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817011580 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 655817011581 Protein export membrane protein; Region: SecD_SecF; cl14618 655817011582 transcriptional regulator YdeO; Provisional; Region: PRK09940 655817011583 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817011584 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 655817011585 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817011586 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 655817011587 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817011588 catalytic residue [active] 655817011589 Haem-binding domain; Region: Haem_bd; pfam14376 655817011590 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 655817011591 trehalase; Provisional; Region: treF; PRK13270 655817011592 Trehalase; Region: Trehalase; pfam01204 655817011593 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655817011594 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817011595 DNA binding residues [nucleotide binding] 655817011596 dimerization interface [polypeptide binding]; other site 655817011597 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655817011598 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817011599 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 655817011600 putative effector binding pocket; other site 655817011601 putative dimerization interface [polypeptide binding]; other site 655817011602 inner membrane protein YhjD; Region: TIGR00766 655817011603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817011604 metabolite-proton symporter; Region: 2A0106; TIGR00883 655817011605 putative substrate translocation pore; other site 655817011606 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 655817011607 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 655817011608 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817011609 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655817011610 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 655817011611 substrate binding site [chemical binding]; other site 655817011612 ATP binding site [chemical binding]; other site 655817011613 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 655817011614 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 655817011615 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 655817011616 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 655817011617 putative diguanylate cyclase; Provisional; Region: PRK13561 655817011618 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 655817011619 metal binding site [ion binding]; metal-binding site 655817011620 active site 655817011621 I-site; other site 655817011622 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817011623 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 655817011624 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655817011625 binding surface 655817011626 TPR motif; other site 655817011627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655817011628 binding surface 655817011629 TPR motif; other site 655817011630 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 655817011631 TPR motif; other site 655817011632 binding surface 655817011633 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 655817011634 endo-1,4-D-glucanase; Provisional; Region: PRK11097 655817011635 cellulose synthase regulator protein; Provisional; Region: PRK11114 655817011636 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 655817011637 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 655817011638 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 655817011639 DXD motif; other site 655817011640 PilZ domain; Region: PilZ; pfam07238 655817011641 cell division protein; Provisional; Region: PRK10037 655817011642 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 655817011643 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 655817011644 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 655817011645 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 655817011646 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 655817011647 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 655817011648 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 655817011649 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 655817011650 serine transporter; Region: stp; TIGR00814 655817011651 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 655817011652 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817011653 Walker A/P-loop; other site 655817011654 ATP binding site [chemical binding]; other site 655817011655 Q-loop/lid; other site 655817011656 ABC transporter signature motif; other site 655817011657 Walker B; other site 655817011658 D-loop; other site 655817011659 H-loop/switch region; other site 655817011660 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 655817011661 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 655817011662 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817011663 Walker A/P-loop; other site 655817011664 ATP binding site [chemical binding]; other site 655817011665 Q-loop/lid; other site 655817011666 ABC transporter signature motif; other site 655817011667 Walker B; other site 655817011668 D-loop; other site 655817011669 H-loop/switch region; other site 655817011670 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 655817011671 dipeptide transporter; Provisional; Region: PRK10913 655817011672 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 655817011673 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817011674 dimer interface [polypeptide binding]; other site 655817011675 conserved gate region; other site 655817011676 putative PBP binding loops; other site 655817011677 ABC-ATPase subunit interface; other site 655817011678 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 655817011679 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817011680 dimer interface [polypeptide binding]; other site 655817011681 conserved gate region; other site 655817011682 putative PBP binding loops; other site 655817011683 ABC-ATPase subunit interface; other site 655817011684 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 655817011685 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 655817011686 peptide binding site [polypeptide binding]; other site 655817011687 phosphoethanolamine transferase; Provisional; Region: PRK11560 655817011688 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 655817011689 Sulfatase; Region: Sulfatase; pfam00884 655817011690 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 655817011691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817011692 putative substrate translocation pore; other site 655817011693 Autotransporter beta-domain; Region: Autotransporter; cl17461 655817011694 Autotransporter beta-domain; Region: Autotransporter; cl17461 655817011695 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 655817011696 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 655817011697 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655817011698 Coenzyme A binding pocket [chemical binding]; other site 655817011699 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 655817011700 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 655817011701 molybdopterin cofactor binding site [chemical binding]; other site 655817011702 substrate binding site [chemical binding]; other site 655817011703 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 655817011704 molybdopterin cofactor binding site; other site 655817011705 putative outer membrane lipoprotein; Provisional; Region: PRK10510 655817011706 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 655817011707 ligand binding site [chemical binding]; other site 655817011708 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 655817011709 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 655817011710 dimerization interface [polypeptide binding]; other site 655817011711 ligand binding site [chemical binding]; other site 655817011712 NADP binding site [chemical binding]; other site 655817011713 catalytic site [active] 655817011714 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 655817011715 Predicted transcriptional regulator [Transcription]; Region: COG2944 655817011716 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655817011717 non-specific DNA binding site [nucleotide binding]; other site 655817011718 salt bridge; other site 655817011719 sequence-specific DNA binding site [nucleotide binding]; other site 655817011720 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 655817011721 DNA-binding site [nucleotide binding]; DNA binding site 655817011722 RNA-binding motif; other site 655817011723 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 655817011724 DALR anticodon binding domain; Region: DALR_1; pfam05746 655817011725 anticodon binding site; other site 655817011726 tRNA binding surface [nucleotide binding]; other site 655817011727 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 655817011728 dimer interface [polypeptide binding]; other site 655817011729 motif 1; other site 655817011730 active site 655817011731 motif 2; other site 655817011732 motif 3; other site 655817011733 YsaB-like lipoprotein; Region: YsaB; pfam13983 655817011734 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 655817011735 Acyltransferase family; Region: Acyl_transf_3; pfam01757 655817011736 hypothetical protein; Provisional; Region: PRK11383 655817011737 yiaA/B two helix domain; Region: YiaAB; pfam05360 655817011738 yiaA/B two helix domain; Region: YiaAB; pfam05360 655817011739 hypothetical protein; Provisional; Region: PRK11403 655817011740 yiaA/B two helix domain; Region: YiaAB; pfam05360 655817011741 xylulokinase; Provisional; Region: PRK15027 655817011742 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 655817011743 N- and C-terminal domain interface [polypeptide binding]; other site 655817011744 active site 655817011745 MgATP binding site [chemical binding]; other site 655817011746 catalytic site [active] 655817011747 metal binding site [ion binding]; metal-binding site 655817011748 xylulose binding site [chemical binding]; other site 655817011749 homodimer interface [polypeptide binding]; other site 655817011750 xylose isomerase; Provisional; Region: PRK05474 655817011751 xylose isomerase; Region: xylose_isom_A; TIGR02630 655817011752 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 655817011753 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 655817011754 putative ligand binding site [chemical binding]; other site 655817011755 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 655817011756 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 655817011757 Walker A/P-loop; other site 655817011758 ATP binding site [chemical binding]; other site 655817011759 Q-loop/lid; other site 655817011760 ABC transporter signature motif; other site 655817011761 Walker B; other site 655817011762 D-loop; other site 655817011763 H-loop/switch region; other site 655817011764 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 655817011765 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 655817011766 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 655817011767 TM-ABC transporter signature motif; other site 655817011768 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 655817011769 putative dimerization interface [polypeptide binding]; other site 655817011770 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655817011771 putative ligand binding site [chemical binding]; other site 655817011772 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817011773 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655817011774 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817011775 hypothetical protein; Provisional; Region: PRK10356 655817011776 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 655817011777 alpha-amylase; Reviewed; Region: malS; PRK09505 655817011778 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 655817011779 active site 655817011780 catalytic site [active] 655817011781 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 655817011782 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655817011783 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817011784 homodimer interface [polypeptide binding]; other site 655817011785 catalytic residue [active] 655817011786 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 655817011787 Transcriptional regulator [Transcription]; Region: IclR; COG1414 655817011788 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 655817011789 Bacterial transcriptional regulator; Region: IclR; pfam01614 655817011790 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 655817011791 Domain of unknown function (DUF386); Region: DUF386; pfam04074 655817011792 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 655817011793 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 655817011794 DctM-like transporters; Region: DctM; pfam06808 655817011795 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 655817011796 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 655817011797 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 655817011798 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 655817011799 putative N- and C-terminal domain interface [polypeptide binding]; other site 655817011800 putative active site [active] 655817011801 MgATP binding site [chemical binding]; other site 655817011802 catalytic site [active] 655817011803 metal binding site [ion binding]; metal-binding site 655817011804 putative xylulose binding site [chemical binding]; other site 655817011805 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 655817011806 active site 655817011807 dimer interface [polypeptide binding]; other site 655817011808 magnesium binding site [ion binding]; other site 655817011809 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 655817011810 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 655817011811 AP (apurinic/apyrimidinic) site pocket; other site 655817011812 DNA interaction; other site 655817011813 Metal-binding active site; metal-binding site 655817011814 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 655817011815 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 655817011816 intersubunit interface [polypeptide binding]; other site 655817011817 active site 655817011818 Zn2+ binding site [ion binding]; other site 655817011819 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 655817011820 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 655817011821 NAD(P) binding site [chemical binding]; other site 655817011822 catalytic residues [active] 655817011823 Fic family protein [Function unknown]; Region: COG3177 655817011824 Fic/DOC family; Region: Fic; pfam02661 655817011825 putative alcohol dehydrogenase; Provisional; Region: PRK09860 655817011826 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 655817011827 dimer interface [polypeptide binding]; other site 655817011828 active site 655817011829 metal binding site [ion binding]; metal-binding site 655817011830 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 655817011831 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 655817011832 G1 box; other site 655817011833 putative GEF interaction site [polypeptide binding]; other site 655817011834 GTP/Mg2+ binding site [chemical binding]; other site 655817011835 Switch I region; other site 655817011836 G2 box; other site 655817011837 G3 box; other site 655817011838 Switch II region; other site 655817011839 G4 box; other site 655817011840 G5 box; other site 655817011841 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 655817011842 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 655817011843 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 655817011844 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 655817011845 selenocysteine synthase; Provisional; Region: PRK04311 655817011846 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 655817011847 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 655817011848 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655817011849 catalytic residue [active] 655817011850 putative glutathione S-transferase; Provisional; Region: PRK10357 655817011851 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 655817011852 putative C-terminal domain interface [polypeptide binding]; other site 655817011853 putative GSH binding site (G-site) [chemical binding]; other site 655817011854 putative dimer interface [polypeptide binding]; other site 655817011855 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 655817011856 dimer interface [polypeptide binding]; other site 655817011857 N-terminal domain interface [polypeptide binding]; other site 655817011858 putative substrate binding pocket (H-site) [chemical binding]; other site 655817011859 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 655817011860 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817011861 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817011862 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 655817011863 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 655817011864 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 655817011865 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 655817011866 active site 655817011867 P-loop; other site 655817011868 phosphorylation site [posttranslational modification] 655817011869 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655817011870 active site 655817011871 phosphorylation site [posttranslational modification] 655817011872 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 655817011873 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 655817011874 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 655817011875 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 655817011876 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 655817011877 hypothetical protein; Provisional; Region: PRK11020 655817011878 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 655817011879 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 655817011880 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 655817011881 trimer interface [polypeptide binding]; other site 655817011882 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 655817011883 trimer interface [polypeptide binding]; other site 655817011884 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 655817011885 Haemagglutinin; Region: HIM; pfam05662 655817011886 Haemagglutinin; Region: HIM; pfam05662 655817011887 YadA-like C-terminal region; Region: YadA; pfam03895 655817011888 L-lactate permease; Provisional; Region: PRK10420 655817011889 glycolate transporter; Provisional; Region: PRK09695 655817011890 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 655817011891 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817011892 DNA-binding site [nucleotide binding]; DNA binding site 655817011893 FCD domain; Region: FCD; pfam07729 655817011894 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 655817011895 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 655817011896 phosphate binding site [ion binding]; other site 655817011897 putative rRNA methylase; Provisional; Region: PRK10358 655817011898 serine acetyltransferase; Provisional; Region: cysE; PRK11132 655817011899 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 655817011900 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 655817011901 trimer interface [polypeptide binding]; other site 655817011902 active site 655817011903 substrate binding site [chemical binding]; other site 655817011904 CoA binding site [chemical binding]; other site 655817011905 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 655817011906 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 655817011907 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 655817011908 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 655817011909 SecA binding site; other site 655817011910 Preprotein binding site; other site 655817011911 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 655817011912 GSH binding site [chemical binding]; other site 655817011913 catalytic residues [active] 655817011914 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 655817011915 active site residue [active] 655817011916 phosphoglyceromutase; Provisional; Region: PRK05434 655817011917 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 655817011918 AmiB activator; Provisional; Region: PRK11637 655817011919 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 655817011920 Peptidase family M23; Region: Peptidase_M23; pfam01551 655817011921 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 655817011922 NodB motif; other site 655817011923 putative active site [active] 655817011924 putative catalytic site [active] 655817011925 Zn binding site [ion binding]; other site 655817011926 putative glycosyl transferase; Provisional; Region: PRK10073 655817011927 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655817011928 active site 655817011929 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 655817011930 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 655817011931 NAD(P) binding site [chemical binding]; other site 655817011932 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 655817011933 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 655817011934 substrate-cofactor binding pocket; other site 655817011935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817011936 catalytic residue [active] 655817011937 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 655817011938 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 655817011939 NADP binding site [chemical binding]; other site 655817011940 homopentamer interface [polypeptide binding]; other site 655817011941 substrate binding site [chemical binding]; other site 655817011942 active site 655817011943 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 655817011944 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 655817011945 putative active site [active] 655817011946 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 655817011947 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 655817011948 putative active site [active] 655817011949 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 655817011950 O-Antigen ligase; Region: Wzy_C; pfam04932 655817011951 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 655817011952 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 655817011953 active site 655817011954 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 655817011955 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 655817011956 Ligand binding site; other site 655817011957 metal-binding site 655817011958 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 655817011959 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 655817011960 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 655817011961 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 655817011962 Ligand binding site; other site 655817011963 metal-binding site 655817011964 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 655817011965 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 655817011966 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 655817011967 Ligand binding site; other site 655817011968 metal-binding site 655817011969 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 655817011970 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 655817011971 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 655817011972 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 655817011973 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 655817011974 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 655817011975 putative active site [active] 655817011976 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 655817011977 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 655817011978 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 655817011979 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 655817011980 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 655817011981 active site 655817011982 (T/H)XGH motif; other site 655817011983 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 655817011984 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 655817011985 DNA binding site [nucleotide binding] 655817011986 catalytic residue [active] 655817011987 H2TH interface [polypeptide binding]; other site 655817011988 putative catalytic residues [active] 655817011989 turnover-facilitating residue; other site 655817011990 intercalation triad [nucleotide binding]; other site 655817011991 8OG recognition residue [nucleotide binding]; other site 655817011992 putative reading head residues; other site 655817011993 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 655817011994 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 655817011995 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 655817011996 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 655817011997 hypothetical protein; Reviewed; Region: PRK00024 655817011998 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 655817011999 MPN+ (JAMM) motif; other site 655817012000 Zinc-binding site [ion binding]; other site 655817012001 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 655817012002 Flavoprotein; Region: Flavoprotein; pfam02441 655817012003 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 655817012004 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 655817012005 trimer interface [polypeptide binding]; other site 655817012006 active site 655817012007 division inhibitor protein; Provisional; Region: slmA; PRK09480 655817012008 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817012009 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 655817012010 active site 655817012011 ribonuclease PH; Reviewed; Region: rph; PRK00173 655817012012 Ribonuclease PH; Region: RNase_PH_bact; cd11362 655817012013 hexamer interface [polypeptide binding]; other site 655817012014 active site 655817012015 hypothetical protein; Provisional; Region: PRK11820 655817012016 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 655817012017 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 655817012018 integrase; Provisional; Region: PRK09692 655817012019 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 655817012020 active site 655817012021 Int/Topo IB signature motif; other site 655817012022 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 655817012023 AntA/AntB antirepressor; Region: AntA; pfam08346 655817012024 D5 N terminal like; Region: D5_N; smart00885 655817012025 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 655817012026 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 655817012027 ProQ/FINO family; Region: ProQ; pfam04352 655817012028 PerC transcriptional activator; Region: PerC; pfam06069 655817012029 Helix-turn-helix domain; Region: HTH_17; cl17695 655817012030 Predicted transcriptional regulator containing an HTH domain and an uncharacterized domain shared with the mammalian protein Schlafen [Transcription]; Region: COG2865 655817012031 Divergent AAA domain; Region: AAA_4; pfam04326 655817012032 ATP-dependent DNA helicase recG C-terminal; Region: HATPase_c_4; pfam13749 655817012033 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 655817012034 BRO family, N-terminal domain; Region: Bro-N; pfam02498 655817012035 Predicted membrane protein [Function unknown]; Region: COG2860 655817012036 UPF0126 domain; Region: UPF0126; pfam03458 655817012037 UPF0126 domain; Region: UPF0126; pfam03458 655817012038 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 655817012039 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 655817012040 nucleotide binding pocket [chemical binding]; other site 655817012041 K-X-D-G motif; other site 655817012042 catalytic site [active] 655817012043 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 655817012044 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 655817012045 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 655817012046 catalytic site [active] 655817012047 G-X2-G-X-G-K; other site 655817012048 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 655817012049 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 655817012050 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655817012051 Zn2+ binding site [ion binding]; other site 655817012052 Mg2+ binding site [ion binding]; other site 655817012053 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 655817012054 synthetase active site [active] 655817012055 NTP binding site [chemical binding]; other site 655817012056 metal binding site [ion binding]; metal-binding site 655817012057 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 655817012058 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 655817012059 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 655817012060 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 655817012061 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 655817012062 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 655817012063 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 655817012064 generic binding surface II; other site 655817012065 ssDNA binding site; other site 655817012066 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655817012067 ATP binding site [chemical binding]; other site 655817012068 putative Mg++ binding site [ion binding]; other site 655817012069 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817012070 nucleotide binding region [chemical binding]; other site 655817012071 ATP-binding site [chemical binding]; other site 655817012072 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 655817012073 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 655817012074 AsmA family; Region: AsmA; pfam05170 655817012075 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 655817012076 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 655817012077 fructokinase; Reviewed; Region: PRK09557 655817012078 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655817012079 nucleotide binding site [chemical binding]; other site 655817012080 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 655817012081 intersubunit interface [polypeptide binding]; other site 655817012082 active site 655817012083 zinc binding site [ion binding]; other site 655817012084 Na+ binding site [ion binding]; other site 655817012085 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 655817012086 intersubunit interface [polypeptide binding]; other site 655817012087 active site 655817012088 zinc binding site [ion binding]; other site 655817012089 Na+ binding site [ion binding]; other site 655817012090 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 655817012091 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 655817012092 active site 655817012093 P-loop; other site 655817012094 phosphorylation site [posttranslational modification] 655817012095 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655817012096 active site 655817012097 phosphorylation site [posttranslational modification] 655817012098 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 655817012099 HTH domain; Region: HTH_11; pfam08279 655817012100 Mga helix-turn-helix domain; Region: Mga; pfam05043 655817012101 PRD domain; Region: PRD; pfam00874 655817012102 PRD domain; Region: PRD; pfam00874 655817012103 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 655817012104 active site 655817012105 P-loop; other site 655817012106 phosphorylation site [posttranslational modification] 655817012107 putative alpha-glucosidase; Provisional; Region: PRK10658 655817012108 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 655817012109 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 655817012110 active site 655817012111 homotrimer interface [polypeptide binding]; other site 655817012112 catalytic site [active] 655817012113 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 655817012114 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 655817012115 putative transporter; Provisional; Region: PRK11462 655817012116 integrase; Provisional; Region: PRK09692 655817012117 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 655817012118 active site 655817012119 Int/Topo IB signature motif; other site 655817012120 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817012121 Walker A/P-loop; other site 655817012122 ATP binding site [chemical binding]; other site 655817012123 Restriction endonuclease; Region: Mrr_cat; pfam04471 655817012124 Predicted transcriptional regulator [Transcription]; Region: COG2378 655817012125 WYL domain; Region: WYL; cl14852 655817012126 Predicted GTPase [General function prediction only]; Region: COG3596 655817012127 YfjP GTPase; Region: YfjP; cd11383 655817012128 G1 box; other site 655817012129 GTP/Mg2+ binding site [chemical binding]; other site 655817012130 Switch I region; other site 655817012131 G2 box; other site 655817012132 Switch II region; other site 655817012133 G3 box; other site 655817012134 G4 box; other site 655817012135 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 655817012136 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 655817012137 Domain of unknown function (DUF932); Region: DUF932; pfam06067 655817012138 hypothetical protein; Reviewed; Region: PRK00024 655817012139 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 655817012140 MPN+ (JAMM) motif; other site 655817012141 Zinc-binding site [ion binding]; other site 655817012142 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 655817012143 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 655817012144 Predicted ATP-binding protein involved in virulence [General function prediction only]; Region: COG3950 655817012145 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817012146 Walker A/P-loop; other site 655817012147 ATP binding site [chemical binding]; other site 655817012148 TIGR02646 family protein; Region: TIGR02646 655817012149 Virulence protein [General function prediction only]; Region: COG3943 655817012150 EamA-like transporter family; Region: EamA; pfam00892 655817012151 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 655817012152 EamA-like transporter family; Region: EamA; pfam00892 655817012153 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 655817012154 lipoprotein, YaeC family; Region: TIGR00363 655817012155 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 655817012156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817012157 putative substrate translocation pore; other site 655817012158 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 655817012159 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 655817012160 cryptic adenine deaminase; Provisional; Region: PRK10027 655817012161 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 655817012162 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 655817012163 active site 655817012164 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 655817012165 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 655817012166 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817012167 putative substrate translocation pore; other site 655817012168 regulatory protein UhpC; Provisional; Region: PRK11663 655817012169 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817012170 putative substrate translocation pore; other site 655817012171 sensory histidine kinase UhpB; Provisional; Region: PRK11644 655817012172 MASE1; Region: MASE1; pfam05231 655817012173 Histidine kinase; Region: HisKA_3; pfam07730 655817012174 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817012175 ATP binding site [chemical binding]; other site 655817012176 Mg2+ binding site [ion binding]; other site 655817012177 G-X-G motif; other site 655817012178 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 655817012179 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817012180 active site 655817012181 phosphorylation site [posttranslational modification] 655817012182 intermolecular recognition site; other site 655817012183 dimerization interface [polypeptide binding]; other site 655817012184 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817012185 DNA binding residues [nucleotide binding] 655817012186 dimerization interface [polypeptide binding]; other site 655817012187 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 655817012188 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 655817012189 putative valine binding site [chemical binding]; other site 655817012190 dimer interface [polypeptide binding]; other site 655817012191 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 655817012192 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 655817012193 PYR/PP interface [polypeptide binding]; other site 655817012194 dimer interface [polypeptide binding]; other site 655817012195 TPP binding site [chemical binding]; other site 655817012196 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 655817012197 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 655817012198 TPP-binding site [chemical binding]; other site 655817012199 dimer interface [polypeptide binding]; other site 655817012200 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 655817012201 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817012202 putative substrate translocation pore; other site 655817012203 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 655817012204 Domain of unknown function (DUF202); Region: DUF202; pfam02656 655817012205 Predicted membrane protein [Function unknown]; Region: COG2149 655817012206 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 655817012207 Sulfatase; Region: Sulfatase; pfam00884 655817012208 putative transporter; Provisional; Region: PRK10484 655817012209 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 655817012210 Na binding site [ion binding]; other site 655817012211 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 655817012212 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817012213 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655817012214 putative transporter; Validated; Region: PRK03818 655817012215 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 655817012216 TrkA-C domain; Region: TrkA_C; pfam02080 655817012217 TrkA-C domain; Region: TrkA_C; pfam02080 655817012218 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 655817012219 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 655817012220 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 655817012221 putative dimer interface [polypeptide binding]; other site 655817012222 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 655817012223 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 655817012224 putative dimer interface [polypeptide binding]; other site 655817012225 hypothetical protein; Provisional; Region: PRK11616 655817012226 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 655817012227 putative oxidoreductase; Provisional; Region: PRK11445 655817012228 hypothetical protein; Provisional; Region: PRK07236 655817012229 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817012230 D-galactonate transporter; Region: 2A0114; TIGR00893 655817012231 putative substrate translocation pore; other site 655817012232 galactonate dehydratase; Provisional; Region: PRK14017 655817012233 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 655817012234 putative active site pocket [active] 655817012235 putative metal binding site [ion binding]; other site 655817012236 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 655817012237 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 655817012238 active site 655817012239 intersubunit interface [polypeptide binding]; other site 655817012240 catalytic residue [active] 655817012241 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 655817012242 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 655817012243 Transcriptional regulators [Transcription]; Region: FadR; COG2186 655817012244 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817012245 DNA-binding site [nucleotide binding]; DNA binding site 655817012246 FCD domain; Region: FCD; pfam07729 655817012247 hypothetical protein; Provisional; Region: PRK10215 655817012248 sugar phosphate phosphatase; Provisional; Region: PRK10513 655817012249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817012250 active site 655817012251 motif I; other site 655817012252 motif II; other site 655817012253 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817012254 hypothetical protein; Provisional; Region: PRK11426 655817012255 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 655817012256 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817012257 Mg2+ binding site [ion binding]; other site 655817012258 G-X-G motif; other site 655817012259 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 655817012260 anchoring element; other site 655817012261 dimer interface [polypeptide binding]; other site 655817012262 ATP binding site [chemical binding]; other site 655817012263 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 655817012264 active site 655817012265 putative metal-binding site [ion binding]; other site 655817012266 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 655817012267 recF protein; Region: recf; TIGR00611 655817012268 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817012269 Walker A/P-loop; other site 655817012270 ATP binding site [chemical binding]; other site 655817012271 Q-loop/lid; other site 655817012272 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817012273 ABC transporter signature motif; other site 655817012274 Walker B; other site 655817012275 D-loop; other site 655817012276 H-loop/switch region; other site 655817012277 DNA polymerase III subunit beta; Validated; Region: PRK05643 655817012278 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 655817012279 putative DNA binding surface [nucleotide binding]; other site 655817012280 dimer interface [polypeptide binding]; other site 655817012281 beta-clamp/clamp loader binding surface; other site 655817012282 beta-clamp/translesion DNA polymerase binding surface; other site 655817012283 DnaA N-terminal domain; Region: DnaA_N; pfam11638 655817012284 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 655817012285 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817012286 Walker A motif; other site 655817012287 ATP binding site [chemical binding]; other site 655817012288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 655817012289 Walker B motif; other site 655817012290 arginine finger; other site 655817012291 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 655817012292 DnaA box-binding interface [nucleotide binding]; other site 655817012293 ribonuclease P; Reviewed; Region: rnpA; PRK01732 655817012294 Haemolytic domain; Region: Haemolytic; cl00506 655817012295 membrane protein insertase; Provisional; Region: PRK01318 655817012296 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 655817012297 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 655817012298 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 655817012299 trmE is a tRNA modification GTPase; Region: trmE; cd04164 655817012300 G1 box; other site 655817012301 GTP/Mg2+ binding site [chemical binding]; other site 655817012302 Switch I region; other site 655817012303 G2 box; other site 655817012304 Switch II region; other site 655817012305 G3 box; other site 655817012306 G4 box; other site 655817012307 G5 box; other site 655817012308 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 655817012309 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 655817012310 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 655817012311 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 655817012312 catalytic residue [active] 655817012313 tryptophan permease TnaB; Provisional; Region: PRK09664 655817012314 aromatic amino acid transport protein; Region: araaP; TIGR00837 655817012315 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 655817012316 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817012317 putative substrate translocation pore; other site 655817012318 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 655817012319 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817012320 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 655817012321 substrate binding pocket [chemical binding]; other site 655817012322 dimerization interface [polypeptide binding]; other site 655817012323 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 655817012324 Predicted flavoprotein [General function prediction only]; Region: COG0431 655817012325 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 655817012326 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 655817012327 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 655817012328 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817012329 active site 655817012330 motif I; other site 655817012331 motif II; other site 655817012332 putative inner membrane protein; Provisional; Region: PRK09823 655817012333 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 655817012334 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 655817012335 active site 655817012336 trimer interface [polypeptide binding]; other site 655817012337 allosteric site; other site 655817012338 active site lid [active] 655817012339 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 655817012340 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 655817012341 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 655817012342 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 655817012343 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 655817012344 trimer interface; other site 655817012345 sugar binding site [chemical binding]; other site 655817012346 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 655817012347 beta-galactosidase; Region: BGL; TIGR03356 655817012348 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 655817012349 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655817012350 active site turn [active] 655817012351 phosphorylation site [posttranslational modification] 655817012352 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655817012353 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 655817012354 HPr interaction site; other site 655817012355 glycerol kinase (GK) interaction site [polypeptide binding]; other site 655817012356 active site 655817012357 phosphorylation site [posttranslational modification] 655817012358 transcriptional antiterminator BglG; Provisional; Region: PRK09772 655817012359 CAT RNA binding domain; Region: CAT_RBD; pfam03123 655817012360 PRD domain; Region: PRD; pfam00874 655817012361 PRD domain; Region: PRD; pfam00874 655817012362 transcriptional regulator PhoU; Provisional; Region: PRK11115 655817012363 PhoU domain; Region: PhoU; pfam01895 655817012364 PhoU domain; Region: PhoU; pfam01895 655817012365 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 655817012366 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 655817012367 Walker A/P-loop; other site 655817012368 ATP binding site [chemical binding]; other site 655817012369 Q-loop/lid; other site 655817012370 ABC transporter signature motif; other site 655817012371 Walker B; other site 655817012372 D-loop; other site 655817012373 H-loop/switch region; other site 655817012374 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 655817012375 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817012376 dimer interface [polypeptide binding]; other site 655817012377 conserved gate region; other site 655817012378 putative PBP binding loops; other site 655817012379 ABC-ATPase subunit interface; other site 655817012380 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 655817012381 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817012382 dimer interface [polypeptide binding]; other site 655817012383 conserved gate region; other site 655817012384 putative PBP binding loops; other site 655817012385 ABC-ATPase subunit interface; other site 655817012386 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817012387 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 655817012388 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 655817012389 glutaminase active site [active] 655817012390 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 655817012391 dimer interface [polypeptide binding]; other site 655817012392 active site 655817012393 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 655817012394 dimer interface [polypeptide binding]; other site 655817012395 active site 655817012396 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 655817012397 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 655817012398 Substrate binding site; other site 655817012399 Mg++ binding site; other site 655817012400 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 655817012401 active site 655817012402 substrate binding site [chemical binding]; other site 655817012403 CoA binding site [chemical binding]; other site 655817012404 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 655817012405 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 655817012406 gamma subunit interface [polypeptide binding]; other site 655817012407 epsilon subunit interface [polypeptide binding]; other site 655817012408 LBP interface [polypeptide binding]; other site 655817012409 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 655817012410 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 655817012411 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 655817012412 alpha subunit interaction interface [polypeptide binding]; other site 655817012413 Walker A motif; other site 655817012414 ATP binding site [chemical binding]; other site 655817012415 Walker B motif; other site 655817012416 inhibitor binding site; inhibition site 655817012417 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 655817012418 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 655817012419 core domain interface [polypeptide binding]; other site 655817012420 delta subunit interface [polypeptide binding]; other site 655817012421 epsilon subunit interface [polypeptide binding]; other site 655817012422 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 655817012423 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 655817012424 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 655817012425 beta subunit interaction interface [polypeptide binding]; other site 655817012426 Walker A motif; other site 655817012427 ATP binding site [chemical binding]; other site 655817012428 Walker B motif; other site 655817012429 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 655817012430 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 655817012431 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 655817012432 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 655817012433 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 655817012434 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 655817012435 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 655817012436 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 655817012437 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 655817012438 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 655817012439 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817012440 S-adenosylmethionine binding site [chemical binding]; other site 655817012441 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 655817012442 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 655817012443 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 655817012444 FMN-binding protein MioC; Provisional; Region: PRK09004 655817012445 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 655817012446 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655817012447 putative DNA binding site [nucleotide binding]; other site 655817012448 putative Zn2+ binding site [ion binding]; other site 655817012449 AsnC family; Region: AsnC_trans_reg; pfam01037 655817012450 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 655817012451 dimer interface [polypeptide binding]; other site 655817012452 active site 655817012453 hypothetical protein; Provisional; Region: yieM; PRK10997 655817012454 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 655817012455 metal ion-dependent adhesion site (MIDAS); other site 655817012456 regulatory ATPase RavA; Provisional; Region: PRK13531 655817012457 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817012458 Walker A motif; other site 655817012459 ATP binding site [chemical binding]; other site 655817012460 Walker B motif; other site 655817012461 arginine finger; other site 655817012462 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 655817012463 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 655817012464 potassium uptake protein; Region: kup; TIGR00794 655817012465 D-ribose pyranase; Provisional; Region: PRK11797 655817012466 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 655817012467 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 655817012468 Walker A/P-loop; other site 655817012469 ATP binding site [chemical binding]; other site 655817012470 Q-loop/lid; other site 655817012471 ABC transporter signature motif; other site 655817012472 Walker B; other site 655817012473 D-loop; other site 655817012474 H-loop/switch region; other site 655817012475 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 655817012476 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 655817012477 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 655817012478 TM-ABC transporter signature motif; other site 655817012479 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 655817012480 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 655817012481 ligand binding site [chemical binding]; other site 655817012482 dimerization interface [polypeptide binding]; other site 655817012483 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 655817012484 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655817012485 substrate binding site [chemical binding]; other site 655817012486 dimer interface [polypeptide binding]; other site 655817012487 ATP binding site [chemical binding]; other site 655817012488 transcriptional repressor RbsR; Provisional; Region: PRK10423 655817012489 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817012490 DNA binding site [nucleotide binding] 655817012491 domain linker motif; other site 655817012492 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 655817012493 dimerization interface [polypeptide binding]; other site 655817012494 ligand binding site [chemical binding]; other site 655817012495 putative transporter; Provisional; Region: PRK10504 655817012496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817012497 putative substrate translocation pore; other site 655817012498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817012499 Transcriptional regulators [Transcription]; Region: FadR; COG2186 655817012500 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817012501 DNA-binding site [nucleotide binding]; DNA binding site 655817012502 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 655817012503 transcriptional regulator HdfR; Provisional; Region: PRK03601 655817012504 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817012505 LysR substrate binding domain; Region: LysR_substrate; pfam03466 655817012506 dimerization interface [polypeptide binding]; other site 655817012507 hypothetical protein; Provisional; Region: PRK11027 655817012508 putative ATP-dependent protease; Provisional; Region: PRK09862 655817012509 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 655817012510 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817012511 Walker A motif; other site 655817012512 ATP binding site [chemical binding]; other site 655817012513 Walker B motif; other site 655817012514 arginine finger; other site 655817012515 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 655817012516 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 655817012517 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 655817012518 PYR/PP interface [polypeptide binding]; other site 655817012519 dimer interface [polypeptide binding]; other site 655817012520 TPP binding site [chemical binding]; other site 655817012521 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 655817012522 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 655817012523 TPP-binding site [chemical binding]; other site 655817012524 dimer interface [polypeptide binding]; other site 655817012525 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 655817012526 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 655817012527 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 655817012528 homodimer interface [polypeptide binding]; other site 655817012529 substrate-cofactor binding pocket; other site 655817012530 catalytic residue [active] 655817012531 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 655817012532 threonine dehydratase; Reviewed; Region: PRK09224 655817012533 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 655817012534 tetramer interface [polypeptide binding]; other site 655817012535 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817012536 catalytic residue [active] 655817012537 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 655817012538 putative Ile/Val binding site [chemical binding]; other site 655817012539 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 655817012540 putative Ile/Val binding site [chemical binding]; other site 655817012541 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817012542 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 655817012543 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 655817012544 putative dimerization interface [polypeptide binding]; other site 655817012545 ketol-acid reductoisomerase; Validated; Region: PRK05225 655817012546 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 655817012547 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 655817012548 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 655817012549 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 655817012550 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 655817012551 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 655817012552 Part of AAA domain; Region: AAA_19; pfam13245 655817012553 Family description; Region: UvrD_C_2; pfam13538 655817012554 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 655817012555 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 655817012556 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 655817012557 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 655817012558 ATP binding site [chemical binding]; other site 655817012559 Mg++ binding site [ion binding]; other site 655817012560 motif III; other site 655817012561 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817012562 nucleotide binding region [chemical binding]; other site 655817012563 ATP-binding site [chemical binding]; other site 655817012564 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 655817012565 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 655817012566 catalytic residues [active] 655817012567 transcription termination factor Rho; Provisional; Region: rho; PRK09376 655817012568 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 655817012569 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 655817012570 RNA binding site [nucleotide binding]; other site 655817012571 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 655817012572 multimer interface [polypeptide binding]; other site 655817012573 Walker A motif; other site 655817012574 ATP binding site [chemical binding]; other site 655817012575 Walker B motif; other site 655817012576 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 655817012577 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 655817012578 Mg++ binding site [ion binding]; other site 655817012579 putative catalytic motif [active] 655817012580 substrate binding site [chemical binding]; other site 655817012581 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 655817012582 Chain length determinant protein; Region: Wzz; pfam02706 655817012583 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 655817012584 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 655817012585 active site 655817012586 homodimer interface [polypeptide binding]; other site 655817012587 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 655817012588 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 655817012589 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 655817012590 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 655817012591 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 655817012592 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 655817012593 NAD binding site [chemical binding]; other site 655817012594 substrate binding site [chemical binding]; other site 655817012595 homodimer interface [polypeptide binding]; other site 655817012596 active site 655817012597 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 655817012598 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 655817012599 substrate binding site; other site 655817012600 tetramer interface; other site 655817012601 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 655817012602 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 655817012603 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 655817012604 inhibitor-cofactor binding pocket; inhibition site 655817012605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817012606 catalytic residue [active] 655817012607 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 655817012608 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 655817012609 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 655817012610 putative common antigen polymerase; Provisional; Region: PRK02975 655817012611 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 655817012612 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 655817012613 putative transport protein YifK; Provisional; Region: PRK10746 655817012614 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 655817012615 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817012616 FeS/SAM binding site; other site 655817012617 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 655817012618 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 655817012619 Sulfatase; Region: Sulfatase; pfam00884 655817012620 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 655817012621 HemY protein N-terminus; Region: HemY_N; pfam07219 655817012622 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 655817012623 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 655817012624 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 655817012625 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 655817012626 active site 655817012627 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 655817012628 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 655817012629 domain interfaces; other site 655817012630 active site 655817012631 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 655817012632 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 655817012633 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 655817012634 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 655817012635 putative iron binding site [ion binding]; other site 655817012636 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 655817012637 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 655817012638 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 655817012639 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 655817012640 hypothetical protein; Provisional; Region: PRK10963 655817012641 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 655817012642 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 655817012643 active site 655817012644 DNA binding site [nucleotide binding] 655817012645 Int/Topo IB signature motif; other site 655817012646 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 655817012647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817012648 motif II; other site 655817012649 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 655817012650 Part of AAA domain; Region: AAA_19; pfam13245 655817012651 Family description; Region: UvrD_C_2; pfam13538 655817012652 Uncharacterized conserved protein [Function unknown]; Region: COG1912 655817012653 Predicted periplasmic protein [Function unknown]; Region: COG3698 655817012654 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 655817012655 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 655817012656 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 655817012657 Cl binding site [ion binding]; other site 655817012658 oligomer interface [polypeptide binding]; other site 655817012659 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 655817012660 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 655817012661 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 655817012662 EamA-like transporter family; Region: EamA; cl17759 655817012663 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 655817012664 CoenzymeA binding site [chemical binding]; other site 655817012665 subunit interaction site [polypeptide binding]; other site 655817012666 PHB binding site; other site 655817012667 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 655817012668 dimerization interface [polypeptide binding]; other site 655817012669 substrate binding site [chemical binding]; other site 655817012670 active site 655817012671 calcium binding site [ion binding]; other site 655817012672 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 655817012673 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655817012674 ATP binding site [chemical binding]; other site 655817012675 putative Mg++ binding site [ion binding]; other site 655817012676 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817012677 nucleotide binding region [chemical binding]; other site 655817012678 ATP-binding site [chemical binding]; other site 655817012679 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 655817012680 Helicase and RNase D C-terminal; Region: HRDC; smart00341 655817012681 threonine efflux system; Provisional; Region: PRK10229 655817012682 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 655817012683 lysophospholipase L2; Provisional; Region: PRK10749 655817012684 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 655817012685 putative hydrolase; Provisional; Region: PRK10976 655817012686 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817012687 active site 655817012688 motif I; other site 655817012689 motif II; other site 655817012690 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817012691 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 655817012692 EamA-like transporter family; Region: EamA; pfam00892 655817012693 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 655817012694 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817012695 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 655817012696 putative dimerization interface [polypeptide binding]; other site 655817012697 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 655817012698 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 655817012699 THF binding site; other site 655817012700 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 655817012701 substrate binding site [chemical binding]; other site 655817012702 THF binding site; other site 655817012703 zinc-binding site [ion binding]; other site 655817012704 Protein of unknown function (DUF796); Region: DUF796; cl01226 655817012705 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 655817012706 tetramer interface [polypeptide binding]; other site 655817012707 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 655817012708 active site 655817012709 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 655817012710 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655817012711 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655817012712 active site turn [active] 655817012713 phosphorylation site [posttranslational modification] 655817012714 transketolase; Reviewed; Region: PRK12753 655817012715 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 655817012716 TPP-binding site [chemical binding]; other site 655817012717 dimer interface [polypeptide binding]; other site 655817012718 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 655817012719 PYR/PP interface [polypeptide binding]; other site 655817012720 dimer interface [polypeptide binding]; other site 655817012721 TPP binding site [chemical binding]; other site 655817012722 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 655817012723 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 655817012724 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 655817012725 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 655817012726 putative active site [active] 655817012727 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 655817012728 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817012729 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 655817012730 dimerization interface [polypeptide binding]; other site 655817012731 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 655817012732 Na binding site [ion binding]; other site 655817012733 allophanate hydrolase; Provisional; Region: PRK08186 655817012734 carbamate kinase; Reviewed; Region: PRK12686 655817012735 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 655817012736 putative substrate binding site [chemical binding]; other site 655817012737 nucleotide binding site [chemical binding]; other site 655817012738 nucleotide binding site [chemical binding]; other site 655817012739 homodimer interface [polypeptide binding]; other site 655817012740 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 655817012741 CoA binding domain; Region: CoA_binding; pfam02629 655817012742 CoA-ligase; Region: Ligase_CoA; pfam00549 655817012743 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 655817012744 Isochorismatase family; Region: Isochorismatase; pfam00857 655817012745 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 655817012746 catalytic triad [active] 655817012747 conserved cis-peptide bond; other site 655817012748 Dienelactone hydrolase family; Region: DLH; pfam01738 655817012749 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 655817012750 uridine phosphorylase; Provisional; Region: PRK11178 655817012751 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 655817012752 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 655817012753 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 655817012754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 655817012755 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 655817012756 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 655817012757 active site 655817012758 intersubunit interface [polypeptide binding]; other site 655817012759 catalytic residue [active] 655817012760 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 655817012761 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 655817012762 Transcriptional regulator [Transcription]; Region: IclR; COG1414 655817012763 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 655817012764 Bacterial transcriptional regulator; Region: IclR; pfam01614 655817012765 DNA recombination protein RmuC; Provisional; Region: PRK10361 655817012766 RmuC family; Region: RmuC; pfam02646 655817012767 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 655817012768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817012769 S-adenosylmethionine binding site [chemical binding]; other site 655817012770 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 655817012771 SCP-2 sterol transfer family; Region: SCP2; pfam02036 655817012772 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 655817012773 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 655817012774 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 655817012775 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 655817012776 sec-independent translocase; Provisional; Region: PRK01770 655817012777 sec-independent translocase; Provisional; Region: tatB; PRK00404 655817012778 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 655817012779 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 655817012780 active site 655817012781 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 655817012782 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 655817012783 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 655817012784 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 655817012785 FMN reductase; Validated; Region: fre; PRK08051 655817012786 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 655817012787 FAD binding pocket [chemical binding]; other site 655817012788 FAD binding motif [chemical binding]; other site 655817012789 phosphate binding motif [ion binding]; other site 655817012790 beta-alpha-beta structure motif; other site 655817012791 NAD binding pocket [chemical binding]; other site 655817012792 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 655817012793 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 655817012794 dimer interface [polypeptide binding]; other site 655817012795 active site 655817012796 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 655817012797 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655817012798 substrate binding site [chemical binding]; other site 655817012799 oxyanion hole (OAH) forming residues; other site 655817012800 trimer interface [polypeptide binding]; other site 655817012801 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 655817012802 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 655817012803 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 655817012804 proline dipeptidase; Provisional; Region: PRK13607 655817012805 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 655817012806 active site 655817012807 hypothetical protein; Provisional; Region: PRK11568 655817012808 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 655817012809 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 655817012810 potassium transporter; Provisional; Region: PRK10750 655817012811 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 655817012812 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 655817012813 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 655817012814 Walker A motif; other site 655817012815 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 655817012816 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 655817012817 GTP binding site; other site 655817012818 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 655817012819 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 655817012820 serine/threonine protein kinase; Provisional; Region: PRK11768 655817012821 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 655817012822 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 655817012823 catalytic residues [active] 655817012824 hinge region; other site 655817012825 alpha helical domain; other site 655817012826 hypothetical protein; Provisional; Region: PRK11367 655817012827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 655817012828 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 655817012829 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 655817012830 putative acyl-acceptor binding pocket; other site 655817012831 DNA polymerase I; Provisional; Region: PRK05755 655817012832 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 655817012833 active site 655817012834 metal binding site 1 [ion binding]; metal-binding site 655817012835 putative 5' ssDNA interaction site; other site 655817012836 metal binding site 3; metal-binding site 655817012837 metal binding site 2 [ion binding]; metal-binding site 655817012838 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 655817012839 putative DNA binding site [nucleotide binding]; other site 655817012840 putative metal binding site [ion binding]; other site 655817012841 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 655817012842 active site 655817012843 catalytic site [active] 655817012844 substrate binding site [chemical binding]; other site 655817012845 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 655817012846 active site 655817012847 DNA binding site [nucleotide binding] 655817012848 catalytic site [active] 655817012849 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 655817012850 G1 box; other site 655817012851 GTP/Mg2+ binding site [chemical binding]; other site 655817012852 Switch I region; other site 655817012853 G2 box; other site 655817012854 G3 box; other site 655817012855 Switch II region; other site 655817012856 G4 box; other site 655817012857 G5 box; other site 655817012858 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 655817012859 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 655817012860 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817012861 FeS/SAM binding site; other site 655817012862 HemN C-terminal domain; Region: HemN_C; pfam06969 655817012863 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 655817012864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817012865 active site 655817012866 phosphorylation site [posttranslational modification] 655817012867 intermolecular recognition site; other site 655817012868 dimerization interface [polypeptide binding]; other site 655817012869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817012870 Walker A motif; other site 655817012871 ATP binding site [chemical binding]; other site 655817012872 Walker B motif; other site 655817012873 arginine finger; other site 655817012874 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 655817012875 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 655817012876 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 655817012877 putative active site [active] 655817012878 heme pocket [chemical binding]; other site 655817012879 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817012880 dimer interface [polypeptide binding]; other site 655817012881 phosphorylation site [posttranslational modification] 655817012882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817012883 ATP binding site [chemical binding]; other site 655817012884 Mg2+ binding site [ion binding]; other site 655817012885 G-X-G motif; other site 655817012886 glutamine synthetase; Provisional; Region: glnA; PRK09469 655817012887 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 655817012888 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 655817012889 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 655817012890 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 655817012891 G1 box; other site 655817012892 putative GEF interaction site [polypeptide binding]; other site 655817012893 GTP/Mg2+ binding site [chemical binding]; other site 655817012894 Switch I region; other site 655817012895 G2 box; other site 655817012896 G3 box; other site 655817012897 Switch II region; other site 655817012898 G4 box; other site 655817012899 G5 box; other site 655817012900 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 655817012901 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 655817012902 transcriptional regulator protein; Region: phnR; TIGR03337 655817012903 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817012904 DNA-binding site [nucleotide binding]; DNA binding site 655817012905 UTRA domain; Region: UTRA; pfam07702 655817012906 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 655817012907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817012908 putative substrate translocation pore; other site 655817012909 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 655817012910 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 655817012911 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 655817012912 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817012913 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 655817012914 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 655817012915 substrate binding site [chemical binding]; other site 655817012916 ATP binding site [chemical binding]; other site 655817012917 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 655817012918 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 655817012919 Class I aldolases; Region: Aldolase_Class_I; cl17187 655817012920 catalytic residue [active] 655817012921 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 655817012922 putative oxidoreductase; Provisional; Region: PRK10083 655817012923 NAD(P) binding site [chemical binding]; other site 655817012924 benzoate transport; Region: 2A0115; TIGR00895 655817012925 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817012926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817012927 shikimate transporter; Provisional; Region: PRK09952 655817012928 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817012929 putative substrate translocation pore; other site 655817012930 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 655817012931 active site 655817012932 catalytic residues [active] 655817012933 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 655817012934 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817012935 motif II; other site 655817012936 hypothetical protein; Reviewed; Region: PRK01637 655817012937 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 655817012938 putative active site [active] 655817012939 dimerization interface [polypeptide binding]; other site 655817012940 putative tRNAtyr binding site [nucleotide binding]; other site 655817012941 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655817012942 Coenzyme A binding pocket [chemical binding]; other site 655817012943 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 655817012944 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 655817012945 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 655817012946 substrate binding pocket [chemical binding]; other site 655817012947 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655817012948 non-specific DNA binding site [nucleotide binding]; other site 655817012949 salt bridge; other site 655817012950 sequence-specific DNA binding site [nucleotide binding]; other site 655817012951 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 655817012952 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 655817012953 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 655817012954 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 655817012955 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 655817012956 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 655817012957 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 655817012958 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 655817012959 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 655817012960 [4Fe-4S] binding site [ion binding]; other site 655817012961 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 655817012962 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 655817012963 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 655817012964 molybdopterin cofactor binding site; other site 655817012965 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 655817012966 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 655817012967 potential frameshift: common BLAST hit: gi|218692185|ref|YP_002400397.1| putative glycoporin 655817012968 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 655817012969 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 655817012970 intersubunit interface [polypeptide binding]; other site 655817012971 active site 655817012972 Zn2+ binding site [ion binding]; other site 655817012973 L-rhamnose isomerase; Provisional; Region: PRK01076 655817012974 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 655817012975 N- and C-terminal domain interface [polypeptide binding]; other site 655817012976 active site 655817012977 putative catalytic site [active] 655817012978 metal binding site [ion binding]; metal-binding site 655817012979 ATP binding site [chemical binding]; other site 655817012980 rhamnulokinase; Provisional; Region: rhaB; PRK10640 655817012981 carbohydrate binding site [chemical binding]; other site 655817012982 transcriptional activator RhaS; Provisional; Region: PRK13503 655817012983 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 655817012984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817012985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817012986 transcriptional activator RhaR; Provisional; Region: PRK13500 655817012987 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 655817012988 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817012989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817012990 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 655817012991 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 655817012992 superoxide dismutase; Provisional; Region: PRK10925 655817012993 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 655817012994 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 655817012995 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 655817012996 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 655817012997 MOSC domain; Region: MOSC; pfam03473 655817012998 3-alpha domain; Region: 3-alpha; pfam03475 655817012999 two-component sensor protein; Provisional; Region: cpxA; PRK09470 655817013000 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655817013001 dimerization interface [polypeptide binding]; other site 655817013002 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817013003 dimer interface [polypeptide binding]; other site 655817013004 phosphorylation site [posttranslational modification] 655817013005 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817013006 ATP binding site [chemical binding]; other site 655817013007 Mg2+ binding site [ion binding]; other site 655817013008 G-X-G motif; other site 655817013009 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 655817013010 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817013011 active site 655817013012 intermolecular recognition site; other site 655817013013 dimerization interface [polypeptide binding]; other site 655817013014 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817013015 DNA binding site [nucleotide binding] 655817013016 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 655817013017 dimer interface [polypeptide binding]; other site 655817013018 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 655817013019 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 655817013020 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 655817013021 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 655817013022 active site 655817013023 ADP/pyrophosphate binding site [chemical binding]; other site 655817013024 dimerization interface [polypeptide binding]; other site 655817013025 allosteric effector site; other site 655817013026 fructose-1,6-bisphosphate binding site; other site 655817013027 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 655817013028 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 655817013029 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 655817013030 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 655817013031 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 655817013032 triosephosphate isomerase; Provisional; Region: PRK14567 655817013033 substrate binding site [chemical binding]; other site 655817013034 dimer interface [polypeptide binding]; other site 655817013035 catalytic triad [active] 655817013036 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 655817013037 Predicted membrane protein [Function unknown]; Region: COG3152 655817013038 hypothetical protein; Provisional; Region: PRK09981 655817013039 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 655817013040 Ligand Binding Site [chemical binding]; other site 655817013041 ferredoxin-NADP reductase; Provisional; Region: PRK10926 655817013042 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 655817013043 FAD binding pocket [chemical binding]; other site 655817013044 FAD binding motif [chemical binding]; other site 655817013045 phosphate binding motif [ion binding]; other site 655817013046 beta-alpha-beta structure motif; other site 655817013047 NAD binding pocket [chemical binding]; other site 655817013048 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 655817013049 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 655817013050 putative active site [active] 655817013051 glycerol kinase; Provisional; Region: glpK; PRK00047 655817013052 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 655817013053 N- and C-terminal domain interface [polypeptide binding]; other site 655817013054 active site 655817013055 MgATP binding site [chemical binding]; other site 655817013056 catalytic site [active] 655817013057 metal binding site [ion binding]; metal-binding site 655817013058 glycerol binding site [chemical binding]; other site 655817013059 homotetramer interface [polypeptide binding]; other site 655817013060 homodimer interface [polypeptide binding]; other site 655817013061 FBP binding site [chemical binding]; other site 655817013062 protein IIAGlc interface [polypeptide binding]; other site 655817013063 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 655817013064 amphipathic channel; other site 655817013065 Asn-Pro-Ala signature motifs; other site 655817013066 septal ring assembly protein ZapB; Provisional; Region: PRK15422 655817013067 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 655817013068 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 655817013069 UbiA prenyltransferase family; Region: UbiA; pfam01040 655817013070 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 655817013071 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817013072 Walker A motif; other site 655817013073 ATP binding site [chemical binding]; other site 655817013074 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 655817013075 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 655817013076 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 655817013077 active site 655817013078 HslU subunit interaction site [polypeptide binding]; other site 655817013079 essential cell division protein FtsN; Provisional; Region: PRK10927 655817013080 cell division protein FtsN; Provisional; Region: PRK12757 655817013081 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817013082 DNA binding site [nucleotide binding] 655817013083 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 655817013084 domain linker motif; other site 655817013085 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 655817013086 dimerization interface [polypeptide binding]; other site 655817013087 ligand binding site [chemical binding]; other site 655817013088 primosome assembly protein PriA; Validated; Region: PRK05580 655817013089 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655817013090 ATP binding site [chemical binding]; other site 655817013091 putative Mg++ binding site [ion binding]; other site 655817013092 helicase superfamily c-terminal domain; Region: HELICc; smart00490 655817013093 ATP-binding site [chemical binding]; other site 655817013094 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 655817013095 hypothetical protein; Provisional; Region: PRK10030 655817013096 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 655817013097 dimerization interface [polypeptide binding]; other site 655817013098 DNA binding site [nucleotide binding] 655817013099 corepressor binding sites; other site 655817013100 cystathionine gamma-synthase; Provisional; Region: PRK08045 655817013101 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 655817013102 homodimer interface [polypeptide binding]; other site 655817013103 substrate-cofactor binding pocket; other site 655817013104 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817013105 catalytic residue [active] 655817013106 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 655817013107 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 655817013108 putative catalytic residues [active] 655817013109 putative nucleotide binding site [chemical binding]; other site 655817013110 putative aspartate binding site [chemical binding]; other site 655817013111 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 655817013112 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 655817013113 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 655817013114 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 655817013115 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 655817013116 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 655817013117 active site 655817013118 metal binding site [ion binding]; metal-binding site 655817013119 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 655817013120 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 655817013121 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 655817013122 active site 655817013123 metal binding site [ion binding]; metal-binding site 655817013124 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 655817013125 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 655817013126 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 655817013127 active site 655817013128 metal binding site [ion binding]; metal-binding site 655817013129 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 655817013130 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 655817013131 FAD binding site [chemical binding]; other site 655817013132 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 655817013133 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 655817013134 heme binding site [chemical binding]; other site 655817013135 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 655817013136 EamA-like transporter family; Region: EamA; pfam00892 655817013137 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 655817013138 EamA-like transporter family; Region: EamA; pfam00892 655817013139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 655817013140 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 655817013141 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 655817013142 dimer interface [polypeptide binding]; other site 655817013143 active site 655817013144 metal binding site [ion binding]; metal-binding site 655817013145 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 655817013146 active site 655817013147 intersubunit interactions; other site 655817013148 catalytic residue [active] 655817013149 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 655817013150 dimerization domain swap beta strand [polypeptide binding]; other site 655817013151 regulatory protein interface [polypeptide binding]; other site 655817013152 active site 655817013153 regulatory phosphorylation site [posttranslational modification]; other site 655817013154 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 655817013155 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 655817013156 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 655817013157 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 655817013158 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655817013159 active site 655817013160 phosphorylation site [posttranslational modification] 655817013161 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 655817013162 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 655817013163 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 655817013164 active site 655817013165 P-loop; other site 655817013166 phosphorylation site [posttranslational modification] 655817013167 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 655817013168 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 655817013169 dimer interface [polypeptide binding]; other site 655817013170 active site 655817013171 glycine loop; other site 655817013172 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cl15377 655817013173 FeS/SAM binding site; other site 655817013174 pyruvate formate lyase II activase; Provisional; Region: PRK10076 655817013175 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 655817013176 active site 655817013177 P-loop; other site 655817013178 phosphorylation site [posttranslational modification] 655817013179 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655817013180 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817013181 hypothetical protein; Provisional; Region: PRK10649 655817013182 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 655817013183 Sulfatase; Region: Sulfatase; pfam00884 655817013184 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 655817013185 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 655817013186 acetylornithine deacetylase; Provisional; Region: PRK05111 655817013187 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 655817013188 metal binding site [ion binding]; metal-binding site 655817013189 putative dimer interface [polypeptide binding]; other site 655817013190 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 655817013191 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 655817013192 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 655817013193 nucleotide binding site [chemical binding]; other site 655817013194 N-acetyl-L-glutamate binding site [chemical binding]; other site 655817013195 argininosuccinate lyase; Provisional; Region: PRK04833 655817013196 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 655817013197 active sites [active] 655817013198 tetramer interface [polypeptide binding]; other site 655817013199 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 655817013200 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 655817013201 putative active site pocket [active] 655817013202 putative metal binding site [ion binding]; other site 655817013203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817013204 D-galactonate transporter; Region: 2A0114; TIGR00893 655817013205 putative substrate translocation pore; other site 655817013206 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 655817013207 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817013208 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 655817013209 dimerization interface [polypeptide binding]; other site 655817013210 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 655817013211 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817013212 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 655817013213 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 655817013214 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 655817013215 metal binding site [ion binding]; metal-binding site 655817013216 putative dimer interface [polypeptide binding]; other site 655817013217 metabolite-proton symporter; Region: 2A0106; TIGR00883 655817013218 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817013219 putative substrate translocation pore; other site 655817013220 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 655817013221 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817013222 hypothetical protein; Provisional; Region: PRK11056 655817013223 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 655817013224 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817013225 S-adenosylmethionine binding site [chemical binding]; other site 655817013226 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 655817013227 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817013228 N-terminal plug; other site 655817013229 ligand-binding site [chemical binding]; other site 655817013230 glutamate racemase; Provisional; Region: PRK00865 655817013231 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 655817013232 FAD binding domain; Region: FAD_binding_4; pfam01565 655817013233 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 655817013234 Biotin operon repressor [Transcription]; Region: BirA; COG1654 655817013235 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 655817013236 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 655817013237 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 655817013238 pantothenate kinase; Provisional; Region: PRK05439 655817013239 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 655817013240 ATP-binding site [chemical binding]; other site 655817013241 CoA-binding site [chemical binding]; other site 655817013242 Mg2+-binding site [ion binding]; other site 655817013243 elongation factor Tu; Reviewed; Region: PRK00049 655817013244 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 655817013245 G1 box; other site 655817013246 GEF interaction site [polypeptide binding]; other site 655817013247 GTP/Mg2+ binding site [chemical binding]; other site 655817013248 Switch I region; other site 655817013249 G2 box; other site 655817013250 G3 box; other site 655817013251 Switch II region; other site 655817013252 G4 box; other site 655817013253 G5 box; other site 655817013254 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 655817013255 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 655817013256 Antibiotic Binding Site [chemical binding]; other site 655817013257 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 655817013258 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 655817013259 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 655817013260 putative homodimer interface [polypeptide binding]; other site 655817013261 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 655817013262 heterodimer interface [polypeptide binding]; other site 655817013263 homodimer interface [polypeptide binding]; other site 655817013264 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 655817013265 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 655817013266 23S rRNA interface [nucleotide binding]; other site 655817013267 L7/L12 interface [polypeptide binding]; other site 655817013268 putative thiostrepton binding site; other site 655817013269 L25 interface [polypeptide binding]; other site 655817013270 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 655817013271 mRNA/rRNA interface [nucleotide binding]; other site 655817013272 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 655817013273 23S rRNA interface [nucleotide binding]; other site 655817013274 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 655817013275 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 655817013276 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 655817013277 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 655817013278 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 655817013279 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 655817013280 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 655817013281 RPB3 interaction site [polypeptide binding]; other site 655817013282 RPB1 interaction site [polypeptide binding]; other site 655817013283 RPB11 interaction site [polypeptide binding]; other site 655817013284 RPB10 interaction site [polypeptide binding]; other site 655817013285 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 655817013286 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 655817013287 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 655817013288 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 655817013289 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 655817013290 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 655817013291 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 655817013292 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 655817013293 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 655817013294 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 655817013295 DNA binding site [nucleotide binding] 655817013296 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 655817013297 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 655817013298 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817013299 FeS/SAM binding site; other site 655817013300 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 655817013301 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 655817013302 ThiS interaction site; other site 655817013303 putative active site [active] 655817013304 tetramer interface [polypeptide binding]; other site 655817013305 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 655817013306 thiS-thiF/thiG interaction site; other site 655817013307 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 655817013308 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 655817013309 ATP binding site [chemical binding]; other site 655817013310 substrate interface [chemical binding]; other site 655817013311 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 655817013312 thiamine phosphate binding site [chemical binding]; other site 655817013313 active site 655817013314 pyrophosphate binding site [ion binding]; other site 655817013315 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 655817013316 ThiC-associated domain; Region: ThiC-associated; pfam13667 655817013317 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 655817013318 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 655817013319 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 655817013320 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 655817013321 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 655817013322 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 655817013323 putative NADH binding site [chemical binding]; other site 655817013324 putative active site [active] 655817013325 nudix motif; other site 655817013326 putative metal binding site [ion binding]; other site 655817013327 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 655817013328 substrate binding site [chemical binding]; other site 655817013329 active site 655817013330 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 655817013331 Active_site [active] 655817013332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 655817013333 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 655817013334 IHF dimer interface [polypeptide binding]; other site 655817013335 IHF - DNA interface [nucleotide binding]; other site 655817013336 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 655817013337 zinc resistance protein; Provisional; Region: zraP; PRK11546 655817013338 dimer interface [polypeptide binding]; other site 655817013339 sensor protein ZraS; Provisional; Region: PRK10364 655817013340 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817013341 dimer interface [polypeptide binding]; other site 655817013342 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817013343 ATP binding site [chemical binding]; other site 655817013344 Mg2+ binding site [ion binding]; other site 655817013345 G-X-G motif; other site 655817013346 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 655817013347 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817013348 active site 655817013349 phosphorylation site [posttranslational modification] 655817013350 intermolecular recognition site; other site 655817013351 dimerization interface [polypeptide binding]; other site 655817013352 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817013353 Walker A motif; other site 655817013354 ATP binding site [chemical binding]; other site 655817013355 Walker B motif; other site 655817013356 arginine finger; other site 655817013357 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 655817013358 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 655817013359 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 655817013360 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 655817013361 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 655817013362 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 655817013363 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 655817013364 purine monophosphate binding site [chemical binding]; other site 655817013365 dimer interface [polypeptide binding]; other site 655817013366 putative catalytic residues [active] 655817013367 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 655817013368 hypothetical protein; Provisional; Region: PRK10039 655817013369 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 655817013370 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655817013371 Coenzyme A binding pocket [chemical binding]; other site 655817013372 homoserine O-succinyltransferase; Provisional; Region: PRK05368 655817013373 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 655817013374 proposed active site lysine [active] 655817013375 conserved cys residue [active] 655817013376 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 655817013377 malate synthase A; Region: malate_syn_A; TIGR01344 655817013378 active site 655817013379 isocitrate lyase; Provisional; Region: PRK15063 655817013380 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 655817013381 tetramer interface [polypeptide binding]; other site 655817013382 active site 655817013383 Mg2+/Mn2+ binding site [ion binding]; other site 655817013384 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 655817013385 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 655817013386 transcriptional repressor IclR; Provisional; Region: PRK11569 655817013387 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 655817013388 Bacterial transcriptional regulator; Region: IclR; pfam01614 655817013389 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 655817013390 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 655817013391 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 655817013392 substrate binding pocket [chemical binding]; other site 655817013393 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 655817013394 B12 binding site [chemical binding]; other site 655817013395 cobalt ligand [ion binding]; other site 655817013396 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 655817013397 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 655817013398 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 655817013399 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 655817013400 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 655817013401 active site pocket [active] 655817013402 oxyanion hole [active] 655817013403 catalytic triad [active] 655817013404 active site nucleophile [active] 655817013405 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 655817013406 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655817013407 putative NAD(P) binding site [chemical binding]; other site 655817013408 catalytic Zn binding site [ion binding]; other site 655817013409 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 655817013410 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 655817013411 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 655817013412 active site 655817013413 phosphorylation site [posttranslational modification] 655817013414 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 655817013415 active pocket/dimerization site; other site 655817013416 active site 655817013417 phosphorylation site [posttranslational modification] 655817013418 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 655817013419 classical (c) SDRs; Region: SDR_c; cd05233 655817013420 NAD(P) binding site [chemical binding]; other site 655817013421 active site 655817013422 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 655817013423 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 655817013424 putative DNA binding site [nucleotide binding]; other site 655817013425 putative Zn2+ binding site [ion binding]; other site 655817013426 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 655817013427 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 655817013428 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 655817013429 RNA binding surface [nucleotide binding]; other site 655817013430 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 655817013431 probable active site [active] 655817013432 hypothetical protein; Provisional; Region: PRK10515 655817013433 aspartate kinase III; Validated; Region: PRK09084 655817013434 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 655817013435 nucleotide binding site [chemical binding]; other site 655817013436 substrate binding site [chemical binding]; other site 655817013437 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 655817013438 lysine allosteric regulatory site; other site 655817013439 dimer interface [polypeptide binding]; other site 655817013440 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 655817013441 dimer interface [polypeptide binding]; other site 655817013442 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 655817013443 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 655817013444 active site 655817013445 dimer interface [polypeptide binding]; other site 655817013446 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 655817013447 dimer interface [polypeptide binding]; other site 655817013448 active site 655817013449 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 655817013450 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 655817013451 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 655817013452 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 655817013453 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 655817013454 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817013455 dimer interface [polypeptide binding]; other site 655817013456 conserved gate region; other site 655817013457 putative PBP binding loops; other site 655817013458 ABC-ATPase subunit interface; other site 655817013459 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817013460 dimer interface [polypeptide binding]; other site 655817013461 conserved gate region; other site 655817013462 putative PBP binding loops; other site 655817013463 ABC-ATPase subunit interface; other site 655817013464 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 655817013465 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 655817013466 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 655817013467 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 655817013468 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 655817013469 Walker A/P-loop; other site 655817013470 ATP binding site [chemical binding]; other site 655817013471 Q-loop/lid; other site 655817013472 ABC transporter signature motif; other site 655817013473 Walker B; other site 655817013474 D-loop; other site 655817013475 H-loop/switch region; other site 655817013476 TOBE domain; Region: TOBE_2; pfam08402 655817013477 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 655817013478 trimer interface; other site 655817013479 sugar binding site [chemical binding]; other site 655817013480 maltose regulon periplasmic protein; Provisional; Region: PRK10564 655817013481 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 655817013482 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 655817013483 UbiA prenyltransferase family; Region: UbiA; pfam01040 655817013484 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 655817013485 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 655817013486 putative acyl-acceptor binding pocket; other site 655817013487 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 655817013488 LexA repressor; Validated; Region: PRK00215 655817013489 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 655817013490 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 655817013491 Catalytic site [active] 655817013492 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 655817013493 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 655817013494 hypothetical protein; Provisional; Region: PRK10428 655817013495 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 655817013496 metal binding site 2 [ion binding]; metal-binding site 655817013497 putative DNA binding helix; other site 655817013498 metal binding site 1 [ion binding]; metal-binding site 655817013499 dimer interface [polypeptide binding]; other site 655817013500 structural Zn2+ binding site [ion binding]; other site 655817013501 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 655817013502 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 655817013503 FMN binding site [chemical binding]; other site 655817013504 active site 655817013505 catalytic residues [active] 655817013506 substrate binding site [chemical binding]; other site 655817013507 phage shock protein G; Reviewed; Region: pspG; PRK09459 655817013508 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 655817013509 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 655817013510 NADP binding site [chemical binding]; other site 655817013511 dimer interface [polypeptide binding]; other site 655817013512 L-aspartate oxidase; Provisional; Region: PRK06175 655817013513 FAD binding domain; Region: FAD_binding_2; pfam00890 655817013514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817013515 metabolite-proton symporter; Region: 2A0106; TIGR00883 655817013516 putative substrate translocation pore; other site 655817013517 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 655817013518 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655817013519 substrate binding site [chemical binding]; other site 655817013520 oxyanion hole (OAH) forming residues; other site 655817013521 trimer interface [polypeptide binding]; other site 655817013522 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 655817013523 Coenzyme A transferase; Region: CoA_trans; smart00882 655817013524 Coenzyme A transferase; Region: CoA_trans; cl17247 655817013525 Transcriptional regulators [Transcription]; Region: PurR; COG1609 655817013526 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817013527 DNA binding site [nucleotide binding] 655817013528 domain linker motif; other site 655817013529 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 655817013530 putative dimerization interface [polypeptide binding]; other site 655817013531 putative ligand binding site [chemical binding]; other site 655817013532 replicative DNA helicase; Provisional; Region: PRK08006 655817013533 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 655817013534 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 655817013535 Walker A motif; other site 655817013536 ATP binding site [chemical binding]; other site 655817013537 Walker B motif; other site 655817013538 DNA binding loops [nucleotide binding] 655817013539 putative lipoprotein; Provisional; Region: PRK10533 655817013540 alanine racemase; Reviewed; Region: alr; PRK00053 655817013541 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 655817013542 active site 655817013543 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 655817013544 substrate binding site [chemical binding]; other site 655817013545 catalytic residues [active] 655817013546 dimer interface [polypeptide binding]; other site 655817013547 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 655817013548 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 655817013549 active site 655817013550 nucleotide binding site [chemical binding]; other site 655817013551 HIGH motif; other site 655817013552 KMSKS motif; other site 655817013553 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 655817013554 AAA domain; Region: AAA_28; pfam13521 655817013555 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 655817013556 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 655817013557 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817013558 homodimer interface [polypeptide binding]; other site 655817013559 catalytic residue [active] 655817013560 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 655817013561 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 655817013562 TPP-binding site [chemical binding]; other site 655817013563 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 655817013564 dimer interface [polypeptide binding]; other site 655817013565 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 655817013566 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 655817013567 E3 interaction surface; other site 655817013568 lipoyl attachment site [posttranslational modification]; other site 655817013569 e3 binding domain; Region: E3_binding; pfam02817 655817013570 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 655817013571 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 655817013572 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 655817013573 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 655817013574 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 655817013575 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 655817013576 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 655817013577 CoA-ligase; Region: Ligase_CoA; pfam00549 655817013578 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 655817013579 CoA binding domain; Region: CoA_binding; smart00881 655817013580 CoA-ligase; Region: Ligase_CoA; pfam00549 655817013581 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 655817013582 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 655817013583 transmembrane helices; other site 655817013584 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 655817013585 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 655817013586 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817013587 active site 655817013588 phosphorylation site [posttranslational modification] 655817013589 intermolecular recognition site; other site 655817013590 dimerization interface [polypeptide binding]; other site 655817013591 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817013592 Walker A motif; other site 655817013593 ATP binding site [chemical binding]; other site 655817013594 Walker B motif; other site 655817013595 arginine finger; other site 655817013596 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 655817013597 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 655817013598 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817013599 dimer interface [polypeptide binding]; other site 655817013600 phosphorylation site [posttranslational modification] 655817013601 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817013602 ATP binding site [chemical binding]; other site 655817013603 Mg2+ binding site [ion binding]; other site 655817013604 G-X-G motif; other site 655817013605 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817013606 active site 655817013607 motif I; other site 655817013608 motif II; other site 655817013609 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 655817013610 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 655817013611 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 655817013612 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 655817013613 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 655817013614 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 655817013615 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 655817013616 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 655817013617 dimer interface [polypeptide binding]; other site 655817013618 ssDNA binding site [nucleotide binding]; other site 655817013619 tetramer (dimer of dimers) interface [polypeptide binding]; other site 655817013620 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 655817013621 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 655817013622 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 655817013623 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 655817013624 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 655817013625 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817013626 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 655817013627 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 655817013628 DNA binding residues [nucleotide binding] 655817013629 dimer interface [polypeptide binding]; other site 655817013630 [2Fe-2S] cluster binding site [ion binding]; other site 655817013631 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 655817013632 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 655817013633 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 655817013634 Transcriptional regulator [Transcription]; Region: LysR; COG0583 655817013635 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817013636 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 655817013637 putative dimerization interface [polypeptide binding]; other site 655817013638 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 655817013639 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 655817013640 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 655817013641 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 655817013642 Na binding site [ion binding]; other site 655817013643 Predicted membrane protein [Function unknown]; Region: COG3162 655817013644 acetyl-CoA synthetase; Provisional; Region: PRK00174 655817013645 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 655817013646 active site 655817013647 CoA binding site [chemical binding]; other site 655817013648 acyl-activating enzyme (AAE) consensus motif; other site 655817013649 AMP binding site [chemical binding]; other site 655817013650 acetate binding site [chemical binding]; other site 655817013651 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 655817013652 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 655817013653 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 655817013654 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 655817013655 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 655817013656 heme lyase subunit NrfE; Provisional; Region: PRK10369 655817013657 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 655817013658 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 655817013659 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 655817013660 binding surface 655817013661 TPR motif; other site 655817013662 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 655817013663 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 655817013664 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 655817013665 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 655817013666 Sel1-like repeats; Region: SEL1; smart00671 655817013667 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 655817013668 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817013669 Walker A/P-loop; other site 655817013670 ATP binding site [chemical binding]; other site 655817013671 Q-loop/lid; other site 655817013672 ABC transporter signature motif; other site 655817013673 Walker B; other site 655817013674 D-loop; other site 655817013675 H-loop/switch region; other site 655817013676 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 655817013677 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817013678 Walker A/P-loop; other site 655817013679 ATP binding site [chemical binding]; other site 655817013680 Q-loop/lid; other site 655817013681 ABC transporter signature motif; other site 655817013682 Walker B; other site 655817013683 D-loop; other site 655817013684 H-loop/switch region; other site 655817013685 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 655817013686 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 655817013687 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817013688 dimer interface [polypeptide binding]; other site 655817013689 conserved gate region; other site 655817013690 ABC-ATPase subunit interface; other site 655817013691 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 655817013692 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817013693 dimer interface [polypeptide binding]; other site 655817013694 conserved gate region; other site 655817013695 putative PBP binding loops; other site 655817013696 ABC-ATPase subunit interface; other site 655817013697 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 655817013698 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 655817013699 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 655817013700 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 655817013701 [4Fe-4S] binding site [ion binding]; other site 655817013702 molybdopterin cofactor binding site; other site 655817013703 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 655817013704 molybdopterin cofactor binding site; other site 655817013705 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 655817013706 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 655817013707 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 655817013708 multidrug resistance protein MdtN; Provisional; Region: PRK10476 655817013709 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 655817013710 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817013711 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 655817013712 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 655817013713 D-allose kinase; Provisional; Region: PRK09698 655817013714 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 655817013715 nucleotide binding site [chemical binding]; other site 655817013716 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 655817013717 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 655817013718 substrate binding site [chemical binding]; other site 655817013719 hexamer interface [polypeptide binding]; other site 655817013720 metal binding site [ion binding]; metal-binding site 655817013721 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 655817013722 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 655817013723 TM-ABC transporter signature motif; other site 655817013724 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 655817013725 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817013726 Walker A/P-loop; other site 655817013727 ATP binding site [chemical binding]; other site 655817013728 Q-loop/lid; other site 655817013729 ABC transporter signature motif; other site 655817013730 Walker B; other site 655817013731 D-loop; other site 655817013732 H-loop/switch region; other site 655817013733 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 655817013734 D-allose transporter subunit; Provisional; Region: PRK09701 655817013735 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 655817013736 ligand binding site [chemical binding]; other site 655817013737 dimerization interface [polypeptide binding]; other site 655817013738 zinc binding site [ion binding]; other site 655817013739 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 655817013740 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 655817013741 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 655817013742 putative active site [active] 655817013743 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 655817013744 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 655817013745 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655817013746 Coenzyme A binding pocket [chemical binding]; other site 655817013747 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 655817013748 AAA domain; Region: AAA_18; pfam13238 655817013749 active site 655817013750 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 655817013751 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 655817013752 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 655817013753 active site 655817013754 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 655817013755 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 655817013756 Walker A/P-loop; other site 655817013757 ATP binding site [chemical binding]; other site 655817013758 Q-loop/lid; other site 655817013759 ABC transporter signature motif; other site 655817013760 Walker B; other site 655817013761 D-loop; other site 655817013762 H-loop/switch region; other site 655817013763 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 655817013764 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 655817013765 Walker A/P-loop; other site 655817013766 ATP binding site [chemical binding]; other site 655817013767 Q-loop/lid; other site 655817013768 ABC transporter signature motif; other site 655817013769 Walker B; other site 655817013770 D-loop; other site 655817013771 H-loop/switch region; other site 655817013772 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 655817013773 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 655817013774 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 655817013775 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 655817013776 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 655817013777 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 655817013778 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817013779 DNA-binding site [nucleotide binding]; DNA binding site 655817013780 UTRA domain; Region: UTRA; pfam07702 655817013781 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 655817013782 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 655817013783 dimer interface [polypeptide binding]; other site 655817013784 conserved gate region; other site 655817013785 putative PBP binding loops; other site 655817013786 ABC-ATPase subunit interface; other site 655817013787 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 655817013788 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 655817013789 substrate binding pocket [chemical binding]; other site 655817013790 membrane-bound complex binding site; other site 655817013791 hinge residues; other site 655817013792 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 655817013793 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 655817013794 Walker A/P-loop; other site 655817013795 ATP binding site [chemical binding]; other site 655817013796 Q-loop/lid; other site 655817013797 ABC transporter signature motif; other site 655817013798 Walker B; other site 655817013799 D-loop; other site 655817013800 H-loop/switch region; other site 655817013801 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 655817013802 dimer interface [polypeptide binding]; other site 655817013803 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 655817013804 hypothetical protein; Provisional; Region: PRK10220 655817013805 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 655817013806 PhnA protein; Region: PhnA; pfam03831 655817013807 hypothetical protein; Provisional; Region: PRK09866 655817013808 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 655817013809 G1 box; other site 655817013810 GTP/Mg2+ binding site [chemical binding]; other site 655817013811 G2 box; other site 655817013812 Switch I region; other site 655817013813 G3 box; other site 655817013814 Switch II region; other site 655817013815 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 655817013816 G2 box; other site 655817013817 Switch I region; other site 655817013818 G3 box; other site 655817013819 Switch II region; other site 655817013820 G4 box; other site 655817013821 G5 box; other site 655817013822 YjcZ-like protein; Region: YjcZ; pfam13990 655817013823 proline/glycine betaine transporter; Provisional; Region: PRK10642 655817013824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817013825 putative substrate translocation pore; other site 655817013826 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 655817013827 sensor protein BasS/PmrB; Provisional; Region: PRK10755 655817013828 HAMP domain; Region: HAMP; pfam00672 655817013829 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817013830 dimer interface [polypeptide binding]; other site 655817013831 phosphorylation site [posttranslational modification] 655817013832 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817013833 ATP binding site [chemical binding]; other site 655817013834 Mg2+ binding site [ion binding]; other site 655817013835 G-X-G motif; other site 655817013836 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 655817013837 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817013838 active site 655817013839 phosphorylation site [posttranslational modification] 655817013840 intermolecular recognition site; other site 655817013841 dimerization interface [polypeptide binding]; other site 655817013842 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817013843 DNA binding site [nucleotide binding] 655817013844 putative metal dependent hydrolase; Provisional; Region: PRK11598 655817013845 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 655817013846 Sulfatase; Region: Sulfatase; pfam00884 655817013847 arginine:agmatin antiporter; Provisional; Region: PRK10644 655817013848 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 655817013849 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817013850 arginine decarboxylase; Provisional; Region: PRK15029 655817013851 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 655817013852 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 655817013853 homodimer interface [polypeptide binding]; other site 655817013854 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817013855 catalytic residue [active] 655817013856 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 655817013857 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 655817013858 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817013859 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817013860 alpha-galactosidase; Provisional; Region: PRK15076 655817013861 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 655817013862 NAD binding site [chemical binding]; other site 655817013863 sugar binding site [chemical binding]; other site 655817013864 divalent metal binding site [ion binding]; other site 655817013865 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 655817013866 dimer interface [polypeptide binding]; other site 655817013867 hypothetical protein; Provisional; Region: PRK09867 655817013868 fumarate hydratase; Provisional; Region: PRK15389 655817013869 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 655817013870 Fumarase C-terminus; Region: Fumerase_C; pfam05683 655817013871 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 655817013872 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 655817013873 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 655817013874 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817013875 active site 655817013876 phosphorylation site [posttranslational modification] 655817013877 intermolecular recognition site; other site 655817013878 dimerization interface [polypeptide binding]; other site 655817013879 Transcriptional regulator; Region: CitT; pfam12431 655817013880 sensory histidine kinase DcuS; Provisional; Region: PRK11086 655817013881 PAS domain; Region: PAS; smart00091 655817013882 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817013883 ATP binding site [chemical binding]; other site 655817013884 Mg2+ binding site [ion binding]; other site 655817013885 G-X-G motif; other site 655817013886 Uncharacterized conserved protein [Function unknown]; Region: COG3592 655817013887 Predicted acetyltransferase [General function prediction only]; Region: COG2388 655817013888 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 655817013889 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 655817013890 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 655817013891 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 655817013892 dimer interface [polypeptide binding]; other site 655817013893 putative anticodon binding site; other site 655817013894 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 655817013895 motif 1; other site 655817013896 active site 655817013897 motif 2; other site 655817013898 motif 3; other site 655817013899 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 655817013900 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817013901 putative substrate translocation pore; other site 655817013902 POT family; Region: PTR2; pfam00854 655817013903 lysine decarboxylase CadA; Provisional; Region: PRK15400 655817013904 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 655817013905 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 655817013906 homodimer interface [polypeptide binding]; other site 655817013907 pyridoxal 5'-phosphate binding site [chemical binding]; other site 655817013908 catalytic residue [active] 655817013909 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 655817013910 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 655817013911 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 655817013912 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817013913 DNA binding site [nucleotide binding] 655817013914 putative transcriptional regulator; Provisional; Region: PRK11640 655817013915 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817013916 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 655817013917 Cytochrome c biogenesis protein [Posttranslational modification, protein turnover, chaperones]; Region: CcdA; COG0785 655817013918 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 655817013919 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 655817013920 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 655817013921 DsbD alpha interface [polypeptide binding]; other site 655817013922 catalytic residues [active] 655817013923 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 655817013924 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 655817013925 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 655817013926 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 655817013927 Aspartase; Region: Aspartase; cd01357 655817013928 active sites [active] 655817013929 tetramer interface [polypeptide binding]; other site 655817013930 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 655817013931 putative transporter; Provisional; Region: PRK11021 655817013932 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 655817013933 oligomerisation interface [polypeptide binding]; other site 655817013934 mobile loop; other site 655817013935 roof hairpin; other site 655817013936 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 655817013937 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 655817013938 ring oligomerisation interface [polypeptide binding]; other site 655817013939 ATP/Mg binding site [chemical binding]; other site 655817013940 stacking interactions; other site 655817013941 hinge regions; other site 655817013942 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 655817013943 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 655817013944 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817013945 FeS/SAM binding site; other site 655817013946 elongation factor P; Validated; Region: PRK00529 655817013947 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 655817013948 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 655817013949 RNA binding site [nucleotide binding]; other site 655817013950 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 655817013951 RNA binding site [nucleotide binding]; other site 655817013952 entericidin A; Provisional; Region: PRK09810 655817013953 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 655817013954 multidrug efflux system protein; Provisional; Region: PRK11431 655817013955 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 655817013956 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 655817013957 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 655817013958 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 655817013959 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 655817013960 Iron-sulfur protein interface; other site 655817013961 proximal quinone binding site [chemical binding]; other site 655817013962 C-subunit interface; other site 655817013963 distal quinone binding site; other site 655817013964 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 655817013965 D-subunit interface [polypeptide binding]; other site 655817013966 Iron-sulfur protein interface; other site 655817013967 proximal quinone binding site [chemical binding]; other site 655817013968 distal quinone binding site [chemical binding]; other site 655817013969 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 655817013970 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 655817013971 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 655817013972 L-aspartate oxidase; Provisional; Region: PRK06175 655817013973 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 655817013974 poxB regulator PoxA; Provisional; Region: PRK09350 655817013975 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 655817013976 motif 1; other site 655817013977 dimer interface [polypeptide binding]; other site 655817013978 active site 655817013979 motif 2; other site 655817013980 motif 3; other site 655817013981 inner membrane transporter YjeM; Provisional; Region: PRK15238 655817013982 putative mechanosensitive channel protein; Provisional; Region: PRK10929 655817013983 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 655817013984 DNA-binding site [nucleotide binding]; DNA binding site 655817013985 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 655817013986 Mechanosensitive ion channel; Region: MS_channel; pfam00924 655817013987 GTPase RsgA; Reviewed; Region: PRK12288 655817013988 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 655817013989 RNA binding site [nucleotide binding]; other site 655817013990 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 655817013991 GTPase/Zn-binding domain interface [polypeptide binding]; other site 655817013992 GTP/Mg2+ binding site [chemical binding]; other site 655817013993 G4 box; other site 655817013994 G5 box; other site 655817013995 G1 box; other site 655817013996 Switch I region; other site 655817013997 G2 box; other site 655817013998 G3 box; other site 655817013999 Switch II region; other site 655817014000 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 655817014001 catalytic site [active] 655817014002 putative active site [active] 655817014003 putative substrate binding site [chemical binding]; other site 655817014004 dimer interface [polypeptide binding]; other site 655817014005 epoxyqueuosine reductase; Region: TIGR00276 655817014006 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 655817014007 putative carbohydrate kinase; Provisional; Region: PRK10565 655817014008 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 655817014009 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 655817014010 putative substrate binding site [chemical binding]; other site 655817014011 putative ATP binding site [chemical binding]; other site 655817014012 Uncharacterized P-loop hydrolase UPF0079; Region: UPF0079; cl00520 655817014013 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 655817014014 AMIN domain; Region: AMIN; pfam11741 655817014015 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 655817014016 active site 655817014017 metal binding site [ion binding]; metal-binding site 655817014018 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 655817014019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817014020 ATP binding site [chemical binding]; other site 655817014021 Mg2+ binding site [ion binding]; other site 655817014022 G-X-G motif; other site 655817014023 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 655817014024 ATP binding site [chemical binding]; other site 655817014025 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 655817014026 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 655817014027 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 655817014028 bacterial Hfq-like; Region: Hfq; cd01716 655817014029 hexamer interface [polypeptide binding]; other site 655817014030 Sm1 motif; other site 655817014031 RNA binding site [nucleotide binding]; other site 655817014032 Sm2 motif; other site 655817014033 GTPase HflX; Provisional; Region: PRK11058 655817014034 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 655817014035 HflX GTPase family; Region: HflX; cd01878 655817014036 G1 box; other site 655817014037 GTP/Mg2+ binding site [chemical binding]; other site 655817014038 Switch I region; other site 655817014039 G2 box; other site 655817014040 G3 box; other site 655817014041 Switch II region; other site 655817014042 G4 box; other site 655817014043 G5 box; other site 655817014044 FtsH protease regulator HflK; Provisional; Region: PRK10930 655817014045 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 655817014046 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 655817014047 FtsH protease regulator HflC; Provisional; Region: PRK11029 655817014048 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 655817014049 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 655817014050 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 655817014051 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 655817014052 GDP-binding site [chemical binding]; other site 655817014053 ACT binding site; other site 655817014054 IMP binding site; other site 655817014055 Predicted transcriptional regulator [Transcription]; Region: COG1959 655817014056 transcriptional repressor NsrR; Provisional; Region: PRK11014 655817014057 exoribonuclease R; Provisional; Region: PRK11642 655817014058 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 655817014059 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 655817014060 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 655817014061 RNB domain; Region: RNB; pfam00773 655817014062 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 655817014063 RNA binding site [nucleotide binding]; other site 655817014064 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 655817014065 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 655817014066 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 655817014067 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 655817014068 PspA/IM30 family; Region: PspA_IM30; pfam04012 655817014069 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 655817014070 Predicted membrane protein [Function unknown]; Region: COG3766 655817014071 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 655817014072 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 655817014073 Predicted integral membrane protein [Function unknown]; Region: COG5463 655817014074 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 655817014075 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 655817014076 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 655817014077 FAD binding site [chemical binding]; other site 655817014078 substrate binding site [chemical binding]; other site 655817014079 catalytic residues [active] 655817014080 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 655817014081 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 655817014082 esterase; Provisional; Region: PRK10566 655817014083 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 655817014084 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 655817014085 transcriptional repressor UlaR; Provisional; Region: PRK13509 655817014086 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 655817014087 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 655817014088 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 655817014089 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 655817014090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 655817014091 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 655817014092 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 655817014093 active site 655817014094 P-loop; other site 655817014095 phosphorylation site [posttranslational modification] 655817014096 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 655817014097 active site 655817014098 phosphorylation site [posttranslational modification] 655817014099 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 655817014100 active site 655817014101 dimer interface [polypeptide binding]; other site 655817014102 magnesium binding site [ion binding]; other site 655817014103 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 655817014104 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 655817014105 AP (apurinic/apyrimidinic) site pocket; other site 655817014106 DNA interaction; other site 655817014107 Metal-binding active site; metal-binding site 655817014108 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 655817014109 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 655817014110 intersubunit interface [polypeptide binding]; other site 655817014111 active site 655817014112 Zn2+ binding site [ion binding]; other site 655817014113 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 655817014114 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 655817014115 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 655817014116 dimer interface [polypeptide binding]; other site 655817014117 ssDNA binding site [nucleotide binding]; other site 655817014118 tetramer (dimer of dimers) interface [polypeptide binding]; other site 655817014119 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 655817014120 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 655817014121 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 655817014122 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 655817014123 Helix-turn-helix domain; Region: HTH_31; pfam13560 655817014124 sequence-specific DNA binding site [nucleotide binding]; other site 655817014125 salt bridge; other site 655817014126 HipA-like N-terminal domain; Region: HipA_N; pfam07805 655817014127 HipA-like C-terminal domain; Region: HipA_C; pfam07804 655817014128 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 655817014129 D-galactonate transporter; Region: 2A0114; TIGR00893 655817014130 putative substrate translocation pore; other site 655817014131 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 655817014132 L-aspartate oxidase; Provisional; Region: PRK06175 655817014133 L-aspartate oxidase; Provisional; Region: PRK06175 655817014134 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 655817014135 Coenzyme A transferase; Region: CoA_trans; smart00882 655817014136 Coenzyme A transferase; Region: CoA_trans; cl17247 655817014137 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 655817014138 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 655817014139 substrate binding site [chemical binding]; other site 655817014140 oxyanion hole (OAH) forming residues; other site 655817014141 trimer interface [polypeptide binding]; other site 655817014142 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 655817014143 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 655817014144 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 655817014145 putative NAD(P) binding site [chemical binding]; other site 655817014146 active site 655817014147 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655817014148 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817014149 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 655817014150 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 655817014151 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 655817014152 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 655817014153 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 655817014154 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 655817014155 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 655817014156 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 655817014157 Hemerythrin-like domain; Region: Hr-like; cd12108 655817014158 Fe binding site [ion binding]; other site 655817014159 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 655817014160 EamA-like transporter family; Region: EamA; pfam00892 655817014161 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 655817014162 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 655817014163 NADP binding site [chemical binding]; other site 655817014164 Predicted transcriptional regulators [Transcription]; Region: COG1733 655817014165 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 655817014166 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 655817014167 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 655817014168 active site 655817014169 metal binding site [ion binding]; metal-binding site 655817014170 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 655817014171 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 655817014172 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 655817014173 active site 655817014174 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 655817014175 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 655817014176 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 655817014177 Domain of unknown function DUF21; Region: DUF21; pfam01595 655817014178 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 655817014179 Transporter associated domain; Region: CorC_HlyC; smart01091 655817014180 methionine sulfoxide reductase A; Provisional; Region: PRK00058 655817014181 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 655817014182 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 655817014183 Surface antigen; Region: Bac_surface_Ag; pfam01103 655817014184 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 655817014185 Family of unknown function (DUF490); Region: DUF490; pfam04357 655817014186 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 655817014187 putative active site pocket [active] 655817014188 dimerization interface [polypeptide binding]; other site 655817014189 putative catalytic residue [active] 655817014190 Sel1-like repeats; Region: SEL1; smart00671 655817014191 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 655817014192 Sel1-like repeats; Region: SEL1; smart00671 655817014193 Sel1-like repeats; Region: SEL1; smart00671 655817014194 Sel1-like repeats; Region: SEL1; smart00671 655817014195 Sel1-like repeats; Region: SEL1; smart00671 655817014196 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 655817014197 Sel1-like repeats; Region: SEL1; smart00671 655817014198 Sel1-like repeats; Region: SEL1; smart00671 655817014199 Sel1-like repeats; Region: SEL1; smart00671 655817014200 Sel1-like repeats; Region: SEL1; smart00671 655817014201 Sel1-like repeats; Region: SEL1; smart00671 655817014202 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 655817014203 dimer interface [polypeptide binding]; other site 655817014204 substrate binding site [chemical binding]; other site 655817014205 metal binding sites [ion binding]; metal-binding site 655817014206 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 655817014207 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 655817014208 putative ligand binding site [chemical binding]; other site 655817014209 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 655817014210 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 655817014211 Walker A/P-loop; other site 655817014212 ATP binding site [chemical binding]; other site 655817014213 Q-loop/lid; other site 655817014214 ABC transporter signature motif; other site 655817014215 Walker B; other site 655817014216 D-loop; other site 655817014217 H-loop/switch region; other site 655817014218 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 655817014219 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 655817014220 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 655817014221 TM-ABC transporter signature motif; other site 655817014222 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 655817014223 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 655817014224 TM-ABC transporter signature motif; other site 655817014225 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 655817014226 AMP binding site [chemical binding]; other site 655817014227 metal binding site [ion binding]; metal-binding site 655817014228 active site 655817014229 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 655817014230 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 655817014231 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 655817014232 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 655817014233 hypothetical protein; Provisional; Region: PRK05255 655817014234 peptidase PmbA; Provisional; Region: PRK11040 655817014235 cytochrome b562; Provisional; Region: PRK15058 655817014236 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 655817014237 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817014238 FeS/SAM binding site; other site 655817014239 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 655817014240 ATP cone domain; Region: ATP-cone; pfam03477 655817014241 Class III ribonucleotide reductase; Region: RNR_III; cd01675 655817014242 effector binding site; other site 655817014243 active site 655817014244 Zn binding site [ion binding]; other site 655817014245 glycine loop; other site 655817014246 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 655817014247 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 655817014248 Ca binding site [ion binding]; other site 655817014249 active site 655817014250 catalytic site [active] 655817014251 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 655817014252 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 655817014253 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 655817014254 active site turn [active] 655817014255 phosphorylation site [posttranslational modification] 655817014256 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 655817014257 trehalose repressor; Provisional; Region: treR; PRK09492 655817014258 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817014259 DNA binding site [nucleotide binding] 655817014260 domain linker motif; other site 655817014261 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 655817014262 dimerization interface [polypeptide binding]; other site 655817014263 ligand binding site [chemical binding]; other site 655817014264 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 655817014265 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 655817014266 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 655817014267 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 655817014268 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817014269 motif II; other site 655817014270 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 655817014271 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 655817014272 homotrimer interaction site [polypeptide binding]; other site 655817014273 putative active site [active] 655817014274 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 655817014275 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 655817014276 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 655817014277 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 655817014278 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 655817014279 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 655817014280 Arginine repressor [Transcription]; Region: ArgR; COG1438 655817014281 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 655817014282 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 655817014283 Predicted membrane protein [Function unknown]; Region: COG1288 655817014284 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 655817014285 ornithine carbamoyltransferase; Validated; Region: PRK02102 655817014286 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 655817014287 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 655817014288 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 655817014289 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 655817014290 putative substrate binding site [chemical binding]; other site 655817014291 nucleotide binding site [chemical binding]; other site 655817014292 nucleotide binding site [chemical binding]; other site 655817014293 homodimer interface [polypeptide binding]; other site 655817014294 arginine deiminase; Provisional; Region: PRK01388 655817014295 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 655817014296 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 655817014297 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 655817014298 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 655817014299 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 655817014300 RNase E inhibitor protein; Provisional; Region: PRK11191 655817014301 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 655817014302 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655817014303 Coenzyme A binding pocket [chemical binding]; other site 655817014304 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 655817014305 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 655817014306 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 655817014307 HIGH motif; other site 655817014308 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 655817014309 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 655817014310 active site 655817014311 KMSKS motif; other site 655817014312 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 655817014313 tRNA binding surface [nucleotide binding]; other site 655817014314 anticodon binding site; other site 655817014315 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 655817014316 DNA polymerase III subunit chi; Validated; Region: PRK05728 655817014317 multifunctional aminopeptidase A; Provisional; Region: PRK00913 655817014318 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 655817014319 interface (dimer of trimers) [polypeptide binding]; other site 655817014320 Substrate-binding/catalytic site; other site 655817014321 Zn-binding sites [ion binding]; other site 655817014322 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 655817014323 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 655817014324 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 655817014325 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 655817014326 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 655817014327 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 655817014328 Walker A motif; other site 655817014329 ATP binding site [chemical binding]; other site 655817014330 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 655817014331 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 655817014332 DNA binding site [nucleotide binding] 655817014333 domain linker motif; other site 655817014334 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 655817014335 putative dimerization interface [polypeptide binding]; other site 655817014336 putative ligand binding site [chemical binding]; other site 655817014337 fructuronate transporter; Provisional; Region: PRK10034; cl15264 655817014338 gluconate transporter; Region: gntP; TIGR00791 655817014339 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 655817014340 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 655817014341 NADP binding site [chemical binding]; other site 655817014342 homodimer interface [polypeptide binding]; other site 655817014343 active site 655817014344 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 655817014345 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 655817014346 putative NAD(P) binding site [chemical binding]; other site 655817014347 catalytic Zn binding site [ion binding]; other site 655817014348 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 655817014349 ATP-binding site [chemical binding]; other site 655817014350 Gluconate-6-phosphate binding site [chemical binding]; other site 655817014351 Shikimate kinase; Region: SKI; pfam01202 655817014352 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 655817014353 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 655817014354 putative NAD(P) binding site [chemical binding]; other site 655817014355 putative substrate binding site [chemical binding]; other site 655817014356 catalytic Zn binding site [ion binding]; other site 655817014357 structural Zn binding site [ion binding]; other site 655817014358 dimer interface [polypeptide binding]; other site 655817014359 integrase; Provisional; Region: PRK09692 655817014360 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 655817014361 active site 655817014362 Int/Topo IB signature motif; other site 655817014363 Part of AAA domain; Region: AAA_19; pfam13245 655817014364 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 655817014365 AAA domain; Region: AAA_12; pfam13087 655817014366 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 655817014367 putative active site [active] 655817014368 catalytic site [active] 655817014369 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 655817014370 Sulfatase; Region: Sulfatase; cl17466 655817014371 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 655817014372 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655817014373 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817014374 DNA binding site [nucleotide binding] 655817014375 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655817014376 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 655817014377 DNA binding residues [nucleotide binding] 655817014378 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 655817014379 Integrase core domain; Region: rve; pfam00665 655817014380 MarR family; Region: MarR_2; cl17246 655817014381 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 655817014382 PapG carbohydrate / receptor binding domain (CBD); PapG, the adhesin of the P-pili, is situated at the tip, mediating the attachment of uropathogenic Escherichia coli to the uroepithelium of the human kidney; PapG has a two-domain architecture: a...; Region: PapG_CBD; cl11617 655817014383 putative membrane interaction site; other site 655817014384 receptor/carbohydrate binding site; other site 655817014385 PapG chaperone-binding domain; Region: PapG_C; pfam03628 655817014386 Fimbrial protein; Region: Fimbrial; pfam00419 655817014387 Fimbrial protein; Region: Fimbrial; pfam00419 655817014388 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817014389 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 655817014390 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 655817014391 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 655817014392 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 655817014393 PapC N-terminal domain; Region: PapC_N; pfam13954 655817014394 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 655817014395 PapC C-terminal domain; Region: PapC_C; pfam13953 655817014396 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817014397 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817014398 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 655817014399 FaeA-like protein; Region: FaeA; pfam04703 655817014400 Uncharacterized protein containing a Zn-ribbon (DUF2116); Region: DUF2116; cl01683 655817014401 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 655817014402 HTH-like domain; Region: HTH_21; pfam13276 655817014403 Integrase core domain; Region: rve; pfam00665 655817014404 Integrase core domain; Region: rve_3; pfam13683 655817014405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 655817014406 Transposase; Region: HTH_Tnp_1; cl17663 655817014407 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817014408 PapC N-terminal domain; Region: PapC_N; pfam13954 655817014409 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 655817014410 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 655817014411 PapC C-terminal domain; Region: PapC_C; pfam13953 655817014412 putative chaperone protein EcpD; Provisional; Region: PRK09926 655817014413 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 655817014414 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 655817014415 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817014416 Predicted membrane protein [Function unknown]; Region: COG2259 655817014417 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 655817014418 FMN-dependent dehydrogenase; Region: FMN_dh; pfam01070 655817014419 phosphate binding site [ion binding]; other site 655817014420 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 655817014421 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 655817014422 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 655817014423 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 655817014424 Transposase; Region: DEDD_Tnp_IS110; pfam01548 655817014425 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 655817014426 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 655817014427 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 655817014428 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 655817014429 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 655817014430 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 655817014431 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 655817014432 Transposase; Region: HTH_Tnp_1; pfam01527 655817014433 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 655817014434 putative transposase OrfB; Reviewed; Region: PHA02517 655817014435 Integrase core domain; Region: rve; pfam00665 655817014436 Winged helix-turn helix; Region: HTH_29; pfam13551 655817014437 Homeodomain-like domain; Region: HTH_23; cl17451 655817014438 Rho-activating domain of cytotoxic necrotizing factor; Region: CNF1; pfam05785 655817014439 Urea transporter; Region: UT; cl01829 655817014440 type I secretion membrane fusion protein, HlyD family; Region: type_I_hlyD; TIGR01843 655817014441 HlyD family secretion protein; Region: HlyD_3; pfam13437 655817014442 A sub-family of peptidase C39 which contains Cyclolysin and Hemolysin processing peptidases. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine...; Region: Peptidase_C39_likeA; cd02417 655817014443 type I secretion system ABC transporter, HlyB family; Region: type_I_sec_HlyB; TIGR01846 655817014444 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 655817014445 ATP-binding cassette domain of hemolysin B, subfamily C; Region: ABCC_Hemolysin; cd03252 655817014446 Walker A/P-loop; other site 655817014447 ATP binding site [chemical binding]; other site 655817014448 Q-loop/lid; other site 655817014449 ABC transporter signature motif; other site 655817014450 Walker B; other site 655817014451 D-loop; other site 655817014452 H-loop/switch region; other site 655817014453 potential frameshift: common BLAST hit: gi|110644662|ref|YP_672392.1| hemolysin A 655817014454 RTX N-terminal domain; Region: RTX; pfam02382 655817014455 RTX toxins and related Ca2+-binding proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2931 655817014456 RTX C-terminal domain; Region: RTX_C; pfam08339 655817014457 RTX N-terminal domain; Region: RTX; pfam02382 655817014458 RTX toxin acyltransferase family; Region: HlyC; pfam02794 655817014459 Sulfite oxidase and related enzymes [General function prediction only]; Region: COG2041 655817014460 Sulfite oxidase (SO) family, molybdopterin binding domain. This molybdopterin cofactor (Moco) binding domain is found in a variety of oxidoreductases, main members of this family are nitrate reductase (NR) and sulfite oxidase (SO). SO catalyzes the...; Region: SO_family_Moco; cl00199 655817014461 Moco binding site; other site 655817014462 metal coordination site [ion binding]; other site 655817014463 Cytochrome b(N-terminal)/b6/petB; Region: Cytochrom_B_N; pfam00033 655817014464 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 655817014465 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817014466 active site 655817014467 phosphorylation site [posttranslational modification] 655817014468 intermolecular recognition site; other site 655817014469 dimerization interface [polypeptide binding]; other site 655817014470 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817014471 DNA binding site [nucleotide binding] 655817014472 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 655817014473 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817014474 dimer interface [polypeptide binding]; other site 655817014475 phosphorylation site [posttranslational modification] 655817014476 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817014477 ATP binding site [chemical binding]; other site 655817014478 Mg2+ binding site [ion binding]; other site 655817014479 G-X-G motif; other site 655817014480 Integrase core domain; Region: rve; pfam00665 655817014481 Integrase core domain; Region: rve_3; pfam13683 655817014482 putative transposase OrfB; Reviewed; Region: PHA02517 655817014483 Integrase core domain; Region: rve; pfam00665 655817014484 Transposase; Region: DEDD_Tnp_IS110; pfam01548 655817014485 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3547 655817014486 Transposase IS116/IS110/IS902 family; Region: Transposase_20; pfam02371 655817014487 Integrase core domain; Region: rve_3; pfam13683 655817014488 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 655817014489 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 655817014490 Walker A/P-loop; other site 655817014491 ATP binding site [chemical binding]; other site 655817014492 Q-loop/lid; other site 655817014493 ABC transporter signature motif; other site 655817014494 Walker B; other site 655817014495 D-loop; other site 655817014496 H-loop/switch region; other site 655817014497 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 655817014498 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817014499 ABC-ATPase subunit interface; other site 655817014500 dimer interface [polypeptide binding]; other site 655817014501 putative PBP binding regions; other site 655817014502 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 655817014503 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 655817014504 dimer interface [polypeptide binding]; other site 655817014505 ABC-ATPase subunit interface; other site 655817014506 putative PBP binding regions; other site 655817014507 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 655817014508 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 655817014509 siderophore binding site; other site 655817014510 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 655817014511 Secretin and TonB N terminus short domain; Region: STN; smart00965 655817014512 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 655817014513 N-terminal plug; other site 655817014514 ligand-binding site [chemical binding]; other site 655817014515 fec operon regulator FecR; Reviewed; Region: PRK09774 655817014516 FecR protein; Region: FecR; pfam04773 655817014517 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 655817014518 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 655817014519 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 655817014520 DNA binding residues [nucleotide binding] 655817014521 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 655817014522 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 655817014523 putative transposase OrfB; Reviewed; Region: PHA02517 655817014524 HTH-like domain; Region: HTH_21; pfam13276 655817014525 Integrase core domain; Region: rve; pfam00665 655817014526 Integrase core domain; Region: rve_2; pfam13333 655817014527 dGTP triphosphohydrolase [Nucleotide transport and metabolism]; Region: Dgt; COG0232 655817014528 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 655817014529 Zn2+ binding site [ion binding]; other site 655817014530 Mg2+ binding site [ion binding]; other site 655817014531 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 655817014532 H-NS histone family; Region: Histone_HNS; pfam00816 655817014533 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 655817014534 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cl15270 655817014535 Predicted transcriptional regulator [Transcription]; Region: AlpA; COG3311 655817014536 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 655817014537 Predicted GTPase [General function prediction only]; Region: COG3596 655817014538 YfjP GTPase; Region: YfjP; cd11383 655817014539 G1 box; other site 655817014540 GTP/Mg2+ binding site [chemical binding]; other site 655817014541 Switch I region; other site 655817014542 G2 box; other site 655817014543 Switch II region; other site 655817014544 G3 box; other site 655817014545 G4 box; other site 655817014546 G5 box; other site 655817014547 HTH domain; Region: HTH_11; cl17392 655817014548 WYL domain; Region: WYL; pfam13280 655817014549 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 655817014550 Domain of unknown function (DUF932); Region: DUF932; pfam06067 655817014551 Antirestriction protein; Region: Antirestrict; pfam03230 655817014552 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 655817014553 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 655817014554 MPN+ (JAMM) motif; other site 655817014555 Zinc-binding site [ion binding]; other site 655817014556 Protein of unknown function (DUF987); Region: DUF987; pfam06174 655817014557 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 655817014558 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 655817014559 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 655817014560 potential frameshift: common BLAST hit: gi|378714782|ref|YP_005279675.1| integrase family protein 655817014561 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 655817014562 active site 655817014563 Int/Topo IB signature motif; other site 655817014564 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 655817014565 Restriction endonuclease [Defense mechanisms]; Region: COG3587 655817014566 Type III restriction enzyme, res subunit; Region: ResIII; pfam04851 655817014567 ATP binding site [chemical binding]; other site 655817014568 putative Mg++ binding site [ion binding]; other site 655817014569 Adenine specific DNA methylase Mod [DNA replication, recombination, and repair]; Region: COG2189 655817014570 DNA methylase; Region: N6_N4_Mtase; cl17433 655817014571 DNA methylase; Region: N6_N4_Mtase; pfam01555 655817014572 DNA methylase; Region: N6_N4_Mtase; cl17433 655817014573 Domain of unknown function (DUF4391); Region: DUF4391; pfam14335 655817014574 N-terminal putative catalytic domain of uncharacterized prokaryotic and archeal HKD family nucleases fused to a DEAD/DEAH box helicase domain; Region: PLDc_N_DEXD_c; cd10311 655817014575 putative active site [active] 655817014576 catalytic site [active] 655817014577 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 655817014578 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655817014579 ATP binding site [chemical binding]; other site 655817014580 putative Mg++ binding site [ion binding]; other site 655817014581 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 655817014582 nucleotide binding region [chemical binding]; other site 655817014583 ATP-binding site [chemical binding]; other site 655817014584 Protein of unknown function (DUF1498); Region: DUF1498; cl17840 655817014585 WYL domain; Region: WYL; pfam13280 655817014586 Putative inner membrane protein (DUF1819); Region: DUF1819; pfam08849 655817014587 Protein of unknown function DUF91; Region: DUF91; cl00709 655817014588 potential frameshift: common BLAST hit: gi|110642861|ref|YP_670591.1| transposase 655817014589 Winged helix-turn helix; Region: HTH_33; pfam13592 655817014590 DDE superfamily endonuclease; Region: DDE_3; pfam13358 655817014591 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3335 655817014592 Homeodomain-like domain; Region: HTH_23; pfam13384 655817014593 Winged helix-turn helix; Region: HTH_29; pfam13551 655817014594 Domain of unknown function (DUF303); Region: DUF303; pfam03629 655817014595 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 655817014596 Kelch motif; Region: Kelch_1; pfam01344 655817014597 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 655817014598 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 655817014599 Int/Topo IB signature motif; other site 655817014600 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 655817014601 PapC C-terminal domain; Region: PapC_C; pfam13953 655817014602 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817014603 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 655817014604 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 655817014605 mannosyl binding site [chemical binding]; other site 655817014606 Fimbrial protein; Region: Fimbrial; pfam00419 655817014607 fructuronate transporter; Provisional; Region: PRK10034 655817014608 gluconate transporter; Region: gntP; TIGR00791 655817014609 mannonate dehydratase; Region: uxuA; TIGR00695 655817014610 mannonate dehydratase; Provisional; Region: PRK03906 655817014611 D-mannonate oxidoreductase; Provisional; Region: PRK15037 655817014612 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 655817014613 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 655817014614 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 655817014615 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817014616 DNA-binding site [nucleotide binding]; DNA binding site 655817014617 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 655817014618 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 655817014619 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 655817014620 cell density-dependent motility repressor; Provisional; Region: PRK10082 655817014621 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 655817014622 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 655817014623 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 655817014624 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 655817014625 dimer interface [polypeptide binding]; other site 655817014626 active site 655817014627 hypothetical protein; Provisional; Region: PRK10519 655817014628 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 655817014629 Nucleoside recognition; Region: Gate; pfam07670 655817014630 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 655817014631 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 655817014632 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 655817014633 SdiA-regulated; Region: SdiA-regulated; pfam06977 655817014634 SdiA-regulated; Region: SdiA-regulated; cd09971 655817014635 putative active site [active] 655817014636 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 655817014637 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 655817014638 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 655817014639 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 655817014640 Predicted membrane protein [Function unknown]; Region: COG2733 655817014641 putative transposase; Provisional; Region: PRK09857 655817014642 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 655817014643 Uncharacterized conserved protein [Function unknown]; Region: COG1479 655817014644 Protein of unknown function DUF262; Region: DUF262; pfam03235 655817014645 Protein of unknown function DUF262; Region: DUF262; pfam03235 655817014646 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 655817014647 Uncharacterized conserved protein [Function unknown]; Region: COG3586 655817014648 endoribonuclease SymE; Provisional; Region: PRK13605 655817014649 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 655817014650 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 655817014651 HsdM N-terminal domain; Region: HsdM_N; pfam12161 655817014652 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 655817014653 Methyltransferase domain; Region: Methyltransf_26; pfam13659 655817014654 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: HsdR; COG4096 655817014655 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 655817014656 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 655817014657 ATP binding site [chemical binding]; other site 655817014658 putative Mg++ binding site [ion binding]; other site 655817014659 Uncharacterized conserved protein [Function unknown]; Region: COG1479 655817014660 Protein of unknown function DUF262; Region: DUF262; pfam03235 655817014661 Protein of unknown function DUF262; Region: DUF262; pfam03235 655817014662 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 655817014663 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 655817014664 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 655817014665 P-loop, Walker A motif; other site 655817014666 Base recognition motif; other site 655817014667 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 655817014668 Uncharacterized small protein [Function unknown]; Region: COG2879 655817014669 carbon starvation protein A; Provisional; Region: PRK15015 655817014670 Carbon starvation protein CstA; Region: CstA; pfam02554 655817014671 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 655817014672 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 655817014673 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 655817014674 dimer interface [polypeptide binding]; other site 655817014675 ligand binding site [chemical binding]; other site 655817014676 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655817014677 dimerization interface [polypeptide binding]; other site 655817014678 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 655817014679 dimer interface [polypeptide binding]; other site 655817014680 putative CheW interface [polypeptide binding]; other site 655817014681 DctM-like transporters; Region: DctM; pfam06808 655817014682 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 655817014683 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 655817014684 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 655817014685 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 655817014686 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 655817014687 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 655817014688 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 655817014689 DNA-binding site [nucleotide binding]; DNA binding site 655817014690 Transcriptional regulators [Transcription]; Region: GntR; COG1802 655817014691 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 655817014692 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 655817014693 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 655817014694 putative NAD(P) binding site [chemical binding]; other site 655817014695 catalytic Zn binding site [ion binding]; other site 655817014696 structural Zn binding site [ion binding]; other site 655817014697 phosphoglycerol transferase I; Provisional; Region: PRK03776 655817014698 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 655817014699 hypothetical protein; Provisional; Region: PRK11667 655817014700 DNA replication protein DnaC; Validated; Region: PRK07952 655817014701 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 655817014702 Walker A motif; other site 655817014703 ATP binding site [chemical binding]; other site 655817014704 Walker B motif; other site 655817014705 primosomal protein DnaI; Provisional; Region: PRK02854 655817014706 hypothetical protein; Provisional; Region: PRK09917 655817014707 Uncharacterized conserved protein [Function unknown]; Region: COG2966 655817014708 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 655817014709 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 655817014710 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817014711 DNA binding residues [nucleotide binding] 655817014712 dimerization interface [polypeptide binding]; other site 655817014713 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 655817014714 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 655817014715 DNA binding residues [nucleotide binding] 655817014716 dimerization interface [polypeptide binding]; other site 655817014717 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 655817014718 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 655817014719 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 655817014720 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 655817014721 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 655817014722 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 655817014723 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 655817014724 S-adenosylmethionine binding site [chemical binding]; other site 655817014725 DNA polymerase III subunit psi; Validated; Region: PRK06856 655817014726 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 655817014727 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 655817014728 Coenzyme A binding pocket [chemical binding]; other site 655817014729 dUMP phosphatase; Provisional; Region: PRK09449 655817014730 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817014731 motif II; other site 655817014732 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 655817014733 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 655817014734 G1 box; other site 655817014735 putative GEF interaction site [polypeptide binding]; other site 655817014736 GTP/Mg2+ binding site [chemical binding]; other site 655817014737 Switch I region; other site 655817014738 G2 box; other site 655817014739 G3 box; other site 655817014740 Switch II region; other site 655817014741 G4 box; other site 655817014742 G5 box; other site 655817014743 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 655817014744 periplasmic protein; Provisional; Region: PRK10568 655817014745 BON domain; Region: BON; pfam04972 655817014746 BON domain; Region: BON; pfam04972 655817014747 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 655817014748 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 655817014749 active site 655817014750 nucleophile elbow; other site 655817014751 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 655817014752 active site 655817014753 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 655817014754 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 655817014755 FeS/SAM binding site; other site 655817014756 hypothetical protein; Provisional; Region: PRK10977 655817014757 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 655817014758 intersubunit interface [polypeptide binding]; other site 655817014759 active site 655817014760 catalytic residue [active] 655817014761 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 655817014762 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 655817014763 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 655817014764 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 655817014765 phosphopentomutase; Provisional; Region: PRK05362 655817014766 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 655817014767 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 655817014768 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 655817014769 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 655817014770 HipA-like N-terminal domain; Region: HipA_N; pfam07805 655817014771 HipA-like C-terminal domain; Region: HipA_C; pfam07804 655817014772 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 655817014773 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 655817014774 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 655817014775 hypothetical protein; Provisional; Region: PRK11246 655817014776 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 655817014777 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 655817014778 motif II; other site 655817014779 DNA repair protein RadA; Region: sms; TIGR00416 655817014780 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 655817014781 Walker A motif/ATP binding site; other site 655817014782 ATP binding site [chemical binding]; other site 655817014783 Walker B motif; other site 655817014784 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 655817014785 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655817014786 non-specific DNA binding site [nucleotide binding]; other site 655817014787 salt bridge; other site 655817014788 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 655817014789 sequence-specific DNA binding site [nucleotide binding]; other site 655817014790 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 655817014791 active site 655817014792 (T/H)XGH motif; other site 655817014793 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 655817014794 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 655817014795 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 655817014796 non-specific DNA binding site [nucleotide binding]; other site 655817014797 salt bridge; other site 655817014798 sequence-specific DNA binding site [nucleotide binding]; other site 655817014799 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 655817014800 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 655817014801 Walker A/P-loop; other site 655817014802 ATP binding site [chemical binding]; other site 655817014803 Q-loop/lid; other site 655817014804 ABC transporter signature motif; other site 655817014805 Walker B; other site 655817014806 D-loop; other site 655817014807 H-loop/switch region; other site 655817014808 ABC transporter; Region: ABC_tran_2; pfam12848 655817014809 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 655817014810 lytic murein transglycosylase; Provisional; Region: PRK11619 655817014811 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 655817014812 N-acetyl-D-glucosamine binding site [chemical binding]; other site 655817014813 catalytic residue [active] 655817014814 Trp operon repressor; Provisional; Region: PRK01381 655817014815 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 655817014816 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 655817014817 catalytic core [active] 655817014818 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 655817014819 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 655817014820 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 655817014821 hypothetical protein; Provisional; Region: PRK10756 655817014822 CreA protein; Region: CreA; pfam05981 655817014823 DNA-binding response regulator CreB; Provisional; Region: PRK11083 655817014824 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817014825 active site 655817014826 phosphorylation site [posttranslational modification] 655817014827 intermolecular recognition site; other site 655817014828 dimerization interface [polypeptide binding]; other site 655817014829 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817014830 DNA binding site [nucleotide binding] 655817014831 sensory histidine kinase CreC; Provisional; Region: PRK11100 655817014832 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 655817014833 dimerization interface [polypeptide binding]; other site 655817014834 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 655817014835 dimer interface [polypeptide binding]; other site 655817014836 phosphorylation site [posttranslational modification] 655817014837 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 655817014838 ATP binding site [chemical binding]; other site 655817014839 Mg2+ binding site [ion binding]; other site 655817014840 G-X-G motif; other site 655817014841 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 655817014842 two-component response regulator; Provisional; Region: PRK11173 655817014843 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 655817014844 active site 655817014845 phosphorylation site [posttranslational modification] 655817014846 intermolecular recognition site; other site 655817014847 dimerization interface [polypeptide binding]; other site 655817014848 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 655817014849 DNA binding site [nucleotide binding] 655817014850 putative RNA methyltransferase; Provisional; Region: PRK10433 655817014851 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050