-- dump date   	20140619_081201
-- class       	Genbank::CDS
-- table       	cds_note
-- id	note
YP_851209.2	multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
YP_851210.1	catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate
YP_851211.1	catalyzes the formation of L-threonine from O-phospho-L-homoserine
YP_851216.1	forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis
YP_851220.1	heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria
YP_851221.2	chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion
YP_851225.1	exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH
YP_851226.1	Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC
YP_851227.1	catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities
YP_851228.1	IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme
YP_851229.1	lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis
YP_851231.1	catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway
YP_851232.1	catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides
YP_851234.1	catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis
YP_851235.1	catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers
YP_851236.1	four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity
YP_851237.1	IS200-related
YP_851238.1	regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons
YP_851239.1	involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities
YP_851240.2	catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA
YP_851242.1	catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine
YP_851243.1	catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA
YP_851244.1	catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism
YP_851245.1	required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase
YP_851246.1	involved in electron transfer during carnitine metabolism
YP_851247.1	FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction
YP_851249.1	Required for full activity of KefC, a potassium-proton antiporter
YP_851250.1	transport system that facilitates potassium-efflux
YP_851251.1	catalyzes the reduction of dihydrofolate to tetrahydrofolate
YP_851252.1	hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP
YP_851253.1	protein associated with Co2+ and Mg2+ efflux
YP_851254.1	catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin
YP_851255.1	catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate)
YP_851256.1	Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB
YP_851257.1	determines N-hexane tolerance and is involved in outer membrane permeability
YP_851258.1	functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system
YP_851259.1	catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs
YP_851260.1	transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA
YP_851261.1	Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C
YP_851262.1	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_851263.1	catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism
YP_851264.1	catalyzes the phosphorylation of ribulose to ribulose 5-phosphate
YP_851265.1	positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose
YP_851269.1	with TbpA and ThiP is part of the thiamine and TPP transport system
YP_851270.1	permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine
YP_851271.1	part of the thiamine and TPP transport system tbpA-thiPQ
YP_851272.1	activates sgrS under glucose-phosphate stress conditions
YP_851273.1	catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D
YP_851274.1	dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate
YP_851275.1	catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis
YP_851276.1	catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis
YP_851277.1	activator for leuABCD operon; member of LysR family of transcriptional activators
YP_851278.1	catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive
YP_851279.1	with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit
YP_851280.1	binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism
YP_851282.1	membrane bound cell division protein at septum containing leucine zipper motif
YP_851284.1	involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate
YP_851286.1	First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan
YP_851287.1	UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation
YP_851288.1	integral membrane protein involved in stabilizing FstZ ring during cell division
YP_851289.1	UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis
YP_851290.1	Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis
YP_851291.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_851292.1	involved in septum formation
YP_851293.1	ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane
YP_851294.1	GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function
YP_851295.1	zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis
YP_851296.1	secM translational pause allows for the initiation of secA translation
YP_851297.1	functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins
YP_851300.1	catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis
YP_851301.1	catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate
YP_851305.1	catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide
YP_851306.1	regulator of AmpC
YP_851307.1	involved in regulation of beta-lactamase; signaling protein
YP_851309.1	similar to bacteriocin protein
YP_851310.1	similar to colicin immunity protein
YP_851311.1	similar to colicin immunity protein
YP_851312.1	similar to colicin immunity protein
YP_851313.1	activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex
YP_851314.1	E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC
YP_851315.1	E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains
YP_851316.1	E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide
YP_851318.1	catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate
YP_851320.1	S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine
YP_851321.1	catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine
YP_851323.1	laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification
YP_851326.1	catalyzes the interconversion of bicarbonate and carbon dioxide
YP_851331.1	Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5)
YP_851333.1	catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine
YP_851334.1	catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate
YP_851339.1	similar to the fimbrial usher protein PapC
YP_851342.1	catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP
YP_851343.1	Polymerase that creates the 3' poly(A) tail found in some mRNA's
YP_851344.2	this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu
YP_851346.1	Regulatory factor involved in maltose metabolism
YP_851348.1	similar in sequence to the ATP-dependent RNA helicase HrpA
YP_851349.1	bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell
YP_851350.1	involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein
YP_851351.1	part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter
YP_851352.1	Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores
YP_851353.1	part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome
YP_851354.1	Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway
YP_851355.1	Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation
YP_851356.1	essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors
YP_851358.1	solute binding component of the vitamin B12 transport system BtuCDF
YP_851359.1	enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine
YP_851360.1	forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate
YP_851361.1	protease Do; required at high temperature; degrades damaged proteins
YP_851362.1	regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization
YP_851364.1	catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway
YP_851365.1	catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein
YP_851366.1	catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn
YP_851367.1	one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit
YP_851369.1	Catalyzes the phosphorylation of UMP to UDP
YP_851370.1	Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs
YP_851371.1	catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate
YP_851372.1	catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate
YP_851373.1	catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate
YP_851374.1	catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response
YP_851375.1	part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins
YP_851377.1	third step of endotoxin (lipidA) synthesis; adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis
YP_851379.1	catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis
YP_851380.1	catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM
YP_851381.1	RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids
YP_851382.1	catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase
YP_851383.1	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein
YP_851386.1	Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase
YP_851387.1	Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination
YP_851392.1	catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro)
YP_851396.1	part of the MetNIQ methionine uptake system
YP_851397.1	part of the metNIQ transport system for methionine
YP_851398.1	Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate
YP_851402.1	catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid
YP_851406.1	catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall
YP_851407.1	catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione
YP_851409.1	An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids
YP_851410.1	3'-5' exonuclease of DNA polymerase III
YP_851413.1	similar to hemolysin co-regulated protein
YP_851415.1	similar to macrophage toxin
YP_851437.1	inactivates vertebrate C-type lysozyme
YP_851438.2	functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA
YP_851439.1	catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate
YP_851446.1	involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function
YP_851448.1	YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function
YP_851450.1	mutations in this gene result in a compromised ability for drug-inducible mexXY expression; expression is inducible by the same ribosome-targeting agents that induce mexXY
YP_851451.1	similar to release factor 1 and 2
YP_851453.1	catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively
YP_851454.1	forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation
YP_851455.1	involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS
YP_851457.1	catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis
YP_851458.1	Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway
YP_851472.1	hemoglobin protease
YP_851483.1	RpmE2; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster do not have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome
YP_851494.1	Involved in disulfide oxidoreductase activity and electron transport
YP_851505.2	catalyzes the oxidation of choline to betaine aldehyde and betain aldehyde to glycine betaine
YP_851506.1	catalyzes the formation of betaine from betaine aldehyde
YP_851507.1	HTH-type; bet1; Repressor involved in choline regulation of the bet genes
YP_851508.1	proton-motive-force-driven choline transporter
YP_851517.1	metallo-dependent hydrolase superfamily; deaminase with metallo-dependent hydrolase domain
YP_851527.1	catalyzes the formation of pyruvate and succinate from 2-methylisocitrate
YP_851528.1	catalyzes the synthesis of 2-methylcitrate from propionyl-CoA and oxaloacetate; also catalyzes the condensation of oxaloacetate with acetyl-CoA but with a lower specificity
YP_851529.1	functions in propionate metabolism; involved in isomerization of (2S,3S)-methylcitrate to (2R,3S)-methylisocitrate; also encodes minor aconitase or dehydratase activity; aconitase C
YP_851530.1	catalyzes the formation of propionyl-CoA using propionate as a substrate; PrpE from Ralstonia solanacearum can produce acetyl-, propionyl-, butyryl- and acrylyl-coenzyme A, and Salmonella enterica produces propionyl- and butyryl-coenzyme A; not expressed in Escherichia coli when grown on propionate/minimal media; ATP-dependent
YP_851532.1	Catalyzes the deamination of cytosine to uracil and ammonia
YP_851533.1	transfers acetyl group from acetyl-CoA to the 6-hydroxyl of galactopyranosides; exact physiological role is unknown
YP_851534.1	lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments
YP_851535.1	forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon
YP_851536.1	transcriptional repressor of lac operon; forms a homotetramer as a dimer of dimers; binds specific sites in lac operon resulting in DNA looping between the operators; binds allolactose as inducer
YP_851540.1	formaldehyde-induced negative regulator of the frmRAB operon
YP_851545.1	with TauB and TauC is responsible for taurine uptake.
YP_851546.1	Part of the ABC transporter complex tauABC involved in taurine import
YP_851548.1	catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers
YP_851549.1	catalyzes the formation of porphobilinogen from 5-aminolevulinate
YP_851552.1	this protein has no known enzymatic function
YP_851553.1	in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope
YP_851557.1	D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli
YP_851561.1	catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis
YP_851562.1	catalyzes the formation of L-proline from pyrroline-5-carboxylate
YP_851564.1	type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_851568.1	Required for efficient pilin antigenic variation
YP_851569.1	catalyzes phosphorylation of fructose; cytosolic enzyme
YP_851570.1	member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers
YP_851571.1	with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity
YP_851572.1	with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity
YP_851573.1	sensor is PhoR; two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB
YP_851574.1	membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB
YP_851576.1	cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation
YP_851578.1	Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP
YP_851579.1	Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step
YP_851580.1	Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr)
YP_851581.1	member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex
YP_851582.1	part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane
YP_851583.1	forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF
YP_851588.1	riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil
YP_851589.1	RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not
YP_851591.1	catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP
YP_851592.1	hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate
YP_851594.1	catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate
YP_851596.1	Required for the synthesis of the thiazole moiety
YP_851598.1	ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis
YP_851599.1	nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription
YP_851601.1	converts protoheme IX and farnesyl diphosphate to heme O
YP_851606.1	in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein
YP_851608.2	positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress
YP_851609.1	Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer
YP_851610.1	hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates
YP_851611.1	binds and unfolds substrates as part of the ClpXP protease
YP_851613.1	histone-like DNA-binding protein
YP_851617.1	YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His
YP_851635.1	regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine
YP_851636.1	small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS
YP_851637.1	PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks
YP_851639.1	catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis
YP_851640.1	catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA
YP_851642.1	involved in a recombinational process of DNA repair, independent of the recBC complex
YP_851643.1	molecular chaperone
YP_851644.2	essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP
YP_851645.1	protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic
YP_851648.1	YbaL; member of the CPA-2 family of antiporters; uncharacterized protein
YP_851650.1	catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides
YP_851658.1	catalyzes the formation of glutamate from glutamine
YP_851660.1	activator of copper-responsive regulon genes
YP_851673.1	catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA
YP_851674.1	activator of the allDC-ylbA operon involved in allantoin utilization
YP_851675.1	catalyzes the formation of glyoxylate from (S)-ureidoglycolate
YP_851676.1	regulates operons involved in the utilization of allantoin
YP_851677.1	catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate
YP_851681.1	Plays a crucial role on both purine and pyrimidine metabolism
YP_851685.1	allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide
YP_851687.1	multicopy suppressor of dominant negative ftsH mutations
YP_851691.1	With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway
YP_851694.1	catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine
YP_851696.1	catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA
YP_851698.1	catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate
YP_851702.1	outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA
YP_851707.1	response regulator in two-component regulatory system with CusS; regulates the copper efflux system
YP_851708.1	with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver
YP_851710.1	with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver
YP_851714.1	catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive
YP_851716.1	ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity
YP_851721.1	with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin
YP_851722.1	part of the ferric enterobactin transport system; necessary for enetrobactin uptake
YP_851724.1	with FepBCD is involved in the transport of ferric enterobactin
YP_851725.1	with FepBCG is involved in the transport of ferric enterobactin
YP_851726.1	protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters
YP_851727.1	with FepCDG is involved in the transport of ferric enterobactin
YP_851729.1	bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate
YP_851731.1	catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin
YP_851734.1	member of the iron-containing alcohol dehydrogenase family; unknown function
YP_851735.1	catalyzes the transfer of an amino moiety
YP_851739.1	Involved in disulfide bond formation
YP_851740.1	with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate
YP_851743.1	Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation
YP_851746.1	catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA
YP_851747.1	2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate
YP_851752.1	regulates the expression of citAB in citrate fermentation
YP_851753.1	responsible for the transport of C4-dicarboxylates during anaerobic growth
YP_851754.1	catalyzes the transfer of palmitate to lipid A
YP_851755.1	may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling
YP_851757.1	catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group
YP_851759.1	lipoyl-[acyl-carrier protein]-protein-N-lipoyltransferse; lipoate-protein ligase B; transfers lipoate to apolipoproteins; involved in lipoate metabolism
YP_851761.1	penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors
YP_851765.1	SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA
YP_851768.1	transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria
YP_851769.1	required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA
YP_851770.1	rare lipoprotein B; involved in the assembly of LPS in the outer membrane
YP_851771.1	leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase
YP_851773.1	Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific
YP_851779.1	Transfers the fatty acyl group on membrane lipoproteins
YP_851783.1	catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A)
YP_851784.1	catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q
YP_851787.1	functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP
YP_851790.1	catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate
YP_851791.1	catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate
YP_851792.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_851799.1	catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate)
YP_851801.1	catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_851804.1	negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer
YP_851805.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_851808.1	negative modulator of the initiation of chromosome replication
YP_851809.1	catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate
YP_851810.1	catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system
YP_851812.1	response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport
YP_851813.1	sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein
YP_851814.1	One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex
YP_851815.1	One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_851816.1	catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions
YP_851818.1	UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent
YP_851824.1	5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity
YP_851827.1	type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH
YP_851830.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol
YP_851831.1	part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase
YP_851832.1	SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide
YP_851833.1	component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA
YP_851834.1	catalyzes the interconversion of succinyl-CoA and succinate
YP_851835.1	Catalyzes the only substrate-level phosphorylation in the TCA cycle
YP_851840.1	catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components
YP_851841.1	membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins
YP_851842.1	membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins
YP_851843.1	inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins
YP_851844.1	forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA
YP_851846.1	periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity
YP_851847.1	3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate
YP_851849.1	involved in zinc efflux across the cytoplasmic membrane
YP_851851.1	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive
YP_851852.1	2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate
YP_851853.1	catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose
YP_851854.1	catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism
YP_851855.1	catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P
YP_851857.2	contains 2 ATP-binding cassettes; involved in the transport of molybdenum
YP_851858.1	represses the modABCD operon and activates the moaABCD and napFDAGHBC operons
YP_851859.1	with ModCB is involved in the high-affinity transport of molybdate
YP_851860.1	part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE
YP_851861.1	Part of the ABC transporter complex modABC involved in molybdenum import
YP_851862.1	YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily
YP_851863.1	catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate
YP_851868.1	outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family
YP_851869.1	YbhB; similar to rat and human kinase inhibitory proteins
YP_851870.1	catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate
YP_851872.1	catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine
YP_851873.2	methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth
YP_851874.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_851875.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion
YP_851877.1	together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z
YP_851879.1	MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis
YP_851880.1	catalyzes the conversion of molybdopterin precursor Z into molybdopterin
YP_851892.1	this helicase is not essential cell growth
YP_851894.1	helicase involved in DNA repair and perhaps also replication
YP_851899.1	Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein
YP_851903.1	similar to ATP-binding component of ABC transporters
YP_851904.1	similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine
YP_851905.1	similar to periplasmic-binding component of ABC transporters
YP_851906.1	binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage
YP_851908.1	OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains
YP_851910.1	Transcriptional regulator that represses the manganese transporter MntH when manganese is present
YP_851917.2	similar to transaldolase from Escherichia coli; many organisms have multiple copies
YP_851918.1	ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase
YP_851919.1	is involved in the formation of active molybdenum cofactor and the chelation of molybdenum
YP_851921.1	with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains
YP_851928.1	catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit
YP_851929.1	BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing
YP_851932.1	penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains
YP_851942.1	functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase
YP_851943.1	YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function
YP_851944.1	NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds
YP_851945.1	responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6
YP_851948.1	part of the PotFGHI ATP-dependent putrescine transporter
YP_851952.1	RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA
YP_851954.1	with ArtPQJI acts to transport arginine across the inner membrane
YP_851955.1	with ArtPMJI transports arginine across the inner membrane
YP_851957.1	With ArtMQJI transports arginine across the inner membrane
YP_851958.1	induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS
YP_851962.1	low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine
YP_851963.1	catalyzes the formation of acetate from pyruvate
YP_851965.1	catalyzes the reduction of hydroxylamine to ammonia and water
YP_851967.1	porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure
YP_851970.1	confers macrolide resistance via active drug efflux
YP_851971.1	with MacA is involved in the export of macrolide
YP_851972.1	involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA
YP_851973.1	ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates
YP_851982.1	leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys
YP_851983.1	in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_851984.1	in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c
YP_851985.1	catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding
YP_851986.1	mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system
YP_851987.1	DNA-binding membrane protein required for chromosome resolution and partitioning
YP_851988.1	participates with LolB in the incorporation of lipoprotein into the outer membrane
YP_851990.1	catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_851996.1	activates pyruvate formate-lyase 1 under anaerobic conditions
YP_851999.1	phage-associated
YP_852000.1	phage-associated
YP_852001.1	phage-associated
YP_852002.1	phage-associated
YP_852008.1	phage-associated
YP_852013.1	phage-associated
YP_852014.1	phage-associated
YP_852015.1	phage-associated
YP_852016.1	phage-associated
YP_852019.1	phage-associated
YP_852021.1	phage-associated
YP_852022.1	phage-associated
YP_852024.1	Phage tail sheath protein
YP_852025.1	transposase for ISEc12
YP_852026.1	ISEc12 ATP-binding protein
YP_852027.1	Phage tail sheath protein
YP_852028.1	Phage tail tube protein FII
YP_852030.1	Phage-related tail protein
YP_852031.1	essential tail protein
YP_852032.1	essential tail protein
YP_852033.1	Phage transcriptional activator; in E. coli K-12 this is in prophage P2 remnant
YP_852034.1	pyruvate formate lyase I
YP_852035.1	Degradation of small molecules: carbon compounds
YP_852038.1	3-phosphoserine/phosphohydroxythreonine aminotransferase; catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine
YP_852039.1	5-enolpyruvylshikimate-3-phosphate synthetase; catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis
YP_852040.1	predicted peptidase with chaperone function
YP_852041.1	Catalyzes the formation of (d)CDP from ATP and (d)CMP
YP_852042.1	30S ribosomal subunit protein S1; in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins
YP_852044.1	conserved inner membrane protein
YP_852045.1	probable transport ATP-binding protein MsbA; involved in the transport of lipid A across the inner membrane
YP_852046.1	transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate
YP_852049.1	CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS
YP_852052.1	predicted S-adenosyl-L-methionine-dependent methyltransferase; involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA
YP_852053.1	Ca2+-binding protein involved in chromosome partitioning; acts with MukB and MukE to condense the chromosome and allow for segregation during cell division
YP_852054.1	protein involved in chromosome partitioning; acts with MukB and MukF to condense the chromosome and allow for segregation during cell division
YP_852055.1	SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects
YP_852056.1	predicted carboxypeptidase
YP_852059.1	aspartate aminotransferase, PLP-dependent; catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_852060.1	outer membrane porin 1a (Ia;b;F); outer membrane porin F; 1a; Ia; b
YP_852061.2	asparagine tRNA synthetase; catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_852062.1	catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate
YP_852064.1	alkanesulfonate transporter subunit; part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease
YP_852065.1	alkanesulfonate transporter subunit; part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease
YP_852066.1	alkanesulfonate monooxygenase, FMNH(2)-dependent; catalyzes the release of sulfite from alkanesulfonates
YP_852067.1	alkanesulfonate transporter subunit; part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease
YP_852069.1	dihydro-orotate oxidase, FMN-linked; catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors
YP_852071.1	predicted 2Fe-2S cluster-containing protein
YP_852072.1	predicted methyltransferase; catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA
YP_852073.1	ABC transporter ATP-binding protein uup; Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth
YP_852077.1	3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase; catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP
YP_852078.1	predicted peptidase
YP_852080.1	OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d
YP_852081.1	SOS cell division inhibitor; suppressor of lon; inhibits cell division and ftsZ ring formation
YP_852083.1	predicted inner membrane protein of unknown function
YP_852085.1	catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand
YP_852086.1	catalyzes the formation of methylglyoxal from glycerone phosphate
YP_852091.1	catalyzes the hydrolysis of acylphosphate
YP_852092.1	transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs
YP_852095.1	involved in hydrogen cycling during fermentative growth
YP_852096.1	enzyme; Energy metabolism, carbon: Aerobic respiration
YP_852097.1	HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1)
YP_852098.1	involved in processing hydrogenase proteins HyaA and HyaB
YP_852103.1	ferredoxin
YP_852104.1	Histidine kinase; Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide
YP_852105.1	periplasmic sensory protein associated with the TorRS two-component regulatory system
YP_852106.1	response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes
YP_852109.1	TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor
YP_852110.1	with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA
YP_852111.1	DnaJ homolog that functions as a co-chaperone of DnaK; functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock
YP_852113.1	stationary phase protein that binds TrpR repressor
YP_852123.1	proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein
YP_852129.1	in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export
YP_852130.1	predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein
YP_852131.1	in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export
YP_852132.1	outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia
YP_852140.1	nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex
YP_852141.1	chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex
YP_852142.1	activates the csgBA and csgDEFG operons involved in biofilm formation
YP_852143.1	CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface
YP_852145.2	involved in autoagglutination of curliated cells; not involved in production of curli fibers
YP_852149.1	required for the transfer of succinyl residues to the glucan backbone
YP_852150.1	involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan
YP_852151.1	necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space
YP_852152.1	Acidic protein msyB
YP_852153.1	YceE/MdtG drug MFS transporter; Confers resistance to fosfomycin and deoxycholate
YP_852154.1	Lipid A biosynthesis lauroyl acyltransferase; Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA
YP_852157.1	cytochrome b561-like protein 2
YP_852158.1	N-methyl-L-tryptophan oxidase; catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids
YP_852159.1	BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing
YP_852160.2	DNA-damage-inducible protein I
YP_852161.1	catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis
YP_852163.1	cofactor involved in the reduction of disulfides
YP_852164.1	transport protein; Confers resistance to norfloxacin and enoxacin
YP_852165.1	Ribosomal-protein-alanine acetyltransferase
YP_852167.1	predicted oxidoreductase, NAD(P)-binding Rossmann-fold domain
YP_852168.1	inner membrane protein
YP_852169.1	flagellar biosynthesis/type III secretory pathway chaperone
YP_852170.1	Negative regulator of flagellin synthesis; regulates the flagellar specific sigma28 transcription factor
YP_852171.1	flagellar biosynthesis; assembly of basal-body periplasmic P ring; required for the assembly of the flagellar basal body P-ring
YP_852172.1	with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella
YP_852173.1	FlgC; with FlgF and B makes up the proximal portion of the flagellar basal body rod
YP_852174.1	acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production
YP_852175.1	the hook connects flagellar basal body to the flagellar filament
YP_852176.1	FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod
YP_852177.1	makes up the distal portion of the flagellar basal body rod
YP_852178.1	part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod
YP_852179.1	part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum
YP_852180.2	Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space
YP_852181.1	with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook
YP_852182.1	with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes
YP_852183.1	bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase
YP_852185.1	catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA
YP_852186.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_852188.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY
YP_852189.1	FabH; FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs
YP_852190.1	FabD
YP_852191.1	FabG; catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_852193.1	FabF; FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_852194.1	PabC; catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate
YP_852196.1	catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP)
YP_852197.1	HolB; catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA
YP_852199.1	PtsG; phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_852200.1	FhuE
YP_852204.1	YcfN; catalyzes the phosphorylation of thiamine to thiamine phosphate
YP_852205.1	NagZ; hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides
YP_852212.1	Mfd
YP_852214.1	part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane
YP_852215.1	outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone
YP_852216.1	part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane
YP_852217.1	catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine
YP_852218.1	Modulates the activities of several enzymes which are inactive in their acetylated form
YP_852221.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate
YP_852222.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component
YP_852223.1	can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component
YP_852224.1	functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase
YP_852225.1	catalyzes the release of the N-terminal amino acid from a tripeptide
YP_852228.1	response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress
YP_852229.1	Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide
YP_852230.1	HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis
YP_852231.1	catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs
YP_852233.1	catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA
YP_852234.1	Converts isocitrate to alpha ketoglutarate
YP_852255.1	DLP12 prophage; Holliday junction resolvase
YP_852256.1	similar to lambdoid prophage
YP_852302.1	works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell
YP_852303.1	ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums
YP_852304.1	blocks the formation of polar Z-ring septums
YP_852310.1	binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization
YP_852311.1	binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization
YP_852312.1	disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein
YP_852313.1	involved in regulation of intracellular pH under alkaline conditions
YP_852314.1	Multifunctional regulator of fatty acid metabolism
YP_852316.1	catalyzes the oxidative deamination of D-amino acids
YP_852317.1	catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA
YP_852318.1	the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli
YP_852319.1	catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine
YP_852324.1	involved in molybdenum transport
YP_852329.1	periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell
YP_852330.1	YcgC; phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL
YP_852331.1	with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone
YP_852332.1	with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase
YP_852333.1	Positively regulates the dhaKLM operon from a sigma-70 promoter
YP_852334.1	translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1
YP_852336.1	YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function
YP_852337.1	role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport
YP_852338.1	catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP
YP_852339.1	An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis
YP_852340.1	Incorporates lipoproteins in the outer membrane after they are released by the LolA protein
YP_852341.1	catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins
YP_852342.1	recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2
YP_852343.1	HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB
YP_852346.1	catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis
YP_852352.1	two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase
YP_852360.1	produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine
YP_852364.1	together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose
YP_852366.1	catalyzes the formation of thymidine 5'-phosphate from thymidine
YP_852376.1	highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein
YP_852377.1	catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol)
YP_852380.2	unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity
YP_852381.1	membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins
YP_852382.1	YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins
YP_852383.1	Involved in cell division; probably involved in intracellular septation
YP_852385.1	receptor for colicin S4
YP_852403.1	YdfR
YP_852408.1	YdfO
YP_852434.1	catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis
YP_852435.1	catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate
YP_852436.1	monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate
YP_852437.1	bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis
YP_852438.1	with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine
YP_852442.1	catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA
YP_852443.1	catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide
YP_852445.1	SohB; periplasmic protein; member of the peptidase S49 family
YP_852447.1	catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity
YP_852448.1	LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation
YP_852449.1	Catalyzes the conversion of citrate to isocitrate
YP_852450.1	catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate
YP_852454.1	type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase
YP_852455.1	involved in start site selection during the initiation of translation
YP_852457.1	c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP
YP_852458.1	Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction
YP_852460.1	Catalyzes a key regulatory step in fatty acid biosynthesis
YP_852467.1	SapD
YP_852468.1	SapC
YP_852471.1	transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor
YP_852472.1	involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF
YP_852473.1	with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock
YP_852474.1	rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide
YP_852489.1	regulates genes involved in the biosynthesis and transport of aromatic amino acids
YP_852490.1	antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein
YP_852499.1	with UspC and UspD is involved in resistance to UV irradiation
YP_852500.1	Global transcription factor that controls the expression of over 100 target genes in response to anoxia
YP_852508.1	exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA
YP_852509.1	TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs
YP_852511.1	Rac prophage
YP_852513.1	The RecE (also known as exonuclease VIII) pathway is an alternative pathway for the initiation of homologous recombination in Escherichia coli. The RecE pathway is activated in recB, recC sbcA (suppressors of recB and recC) mutants. Activation of the RecE pathway results in the production of at least two phage proteins relevant for recombinational repair. RecE is a duplex DNA-specific exonuclease which produces 3' overhangs in duplex DNA by preferentially degrading the 5'-ending strands. Recombinational repair of E.coli chromosomal DNA involves as well other proteins: RecA, RecF, RecJ, RecO, RecR, and RuvC.
YP_852514.1	Rac prophage hypothetical protein
YP_852530.1	ParB-like
YP_852535.1	chemotaxis protein
YP_852560.2	outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA
YP_852578.1	involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain
YP_852580.1	NAD-linked
YP_852582.2	B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm
YP_852586.1	involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans
YP_852590.1	with TehA confers resistance to tellurite
YP_852600.1	catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation
YP_852625.1	nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase
YP_852627.1	addiction system protein
YP_852628.1	similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs
YP_852629.2	malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate
YP_852632.1	heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate
YP_852641.1	regulates the cellular response to acid resistance
YP_852642.1	in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family
YP_852653.1	catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate
YP_852655.1	catalyzes the formation of D-tagaturonate from D-altronate
YP_852658.1	catalyzes the formation of glutamate from glutamine
YP_852659.1	in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase
YP_852662.1	protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function
YP_852663.1	Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes
YP_852664.1	transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF
YP_852665.1	converts 6-phospho-beta-D-glucosyl-(1,4)-D-glucose to glucose and glucose 6-phosphate; required for cellobiose uptake and metabolism
YP_852672.1	YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters
YP_852675.1	NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine
YP_852690.1	binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane
YP_852692.1	DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium
YP_852696.1	required for growth and survival under moderately acid conditions
YP_852698.1	with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS
YP_852699.1	with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS
YP_852700.1	transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes
YP_852701.1	catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme
YP_852702.1	forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm
YP_852707.1	response regulator in two-component regulatory system with RstB
YP_852709.1	binds to DNA replication terminator sequences to prevent passage of replication forks
YP_852710.1	class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle
YP_852718.1	Acts on the hydroxyl group at position 7 of the steroid frame
YP_852719.1	regulates malXY which are involved in maltose-glucose transport
YP_852720.1	phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site
YP_852722.1	catalyzes the formation of inosine from adenosine
YP_852727.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_852728.1	part of membrane-bound complex thought to be involved in electron transport to nitrogen
YP_852729.1	RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents
YP_852730.1	part of membrane-bound complex hought to be involved in electron transport to nitrogen
YP_852731.1	in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase
YP_852732.1	DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines
YP_852733.1	mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation
YP_852735.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal
YP_852736.1	catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr)
YP_852737.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate
YP_852738.1	MliC; membrane-bound lysozyme inhibitor of c-type lysozyme
YP_852739.1	catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling
YP_852741.1	Transcription regulator that can both activate or repress expression
YP_852744.1	SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water
YP_852747.1	FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide
YP_852748.1	Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione
YP_852749.1	Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A)
YP_852751.1	SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals
YP_852753.1	binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers
YP_852755.1	uncharacterized member of the major facilitator superfamily (MFS)
YP_852756.1	catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge
YP_852757.1	catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine
YP_852758.1	NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones
YP_852769.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_852771.1	Acts with SufS to catalyze the formation of L-alanine from L-cysteine
YP_852772.1	catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine
YP_852773.1	with SufBC activates cysteine desulfurase SufS
YP_852774.1	part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE
YP_852775.1	with SufCD activates cysteine desulfurase SufS
YP_852776.1	functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein
YP_852780.1	YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function
YP_852783.1	YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate
YP_852784.1	catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis
YP_852786.2	may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain
YP_852788.1	YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain
YP_852789.1	May play a role in a redox process
YP_852792.1	acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids
YP_852793.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_852795.1	tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate
YP_852799.1	ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell
YP_852800.1	similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane
YP_852801.1	with BtuD and BtuF transports vitamin B12 into the cell
YP_852802.1	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily
YP_852803.2	catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily
YP_852804.1	binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit
YP_852806.1	catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_852813.1	YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate
YP_852817.1	Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide
YP_852820.1	represses the celABCDF-ydjC operon involved in carbon uptake
YP_852821.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_852822.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_852823.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake
YP_852824.1	osmotically-inducible lipoprotein E; activator of ntr-like gene protein
YP_852825.1	catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers
YP_852826.1	3' incision activity; acts with UvrC
YP_852828.1	periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP
YP_852829.1	catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism
YP_852830.1	catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation
YP_852833.1	catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate
YP_852834.1	removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction
YP_852846.1	converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer
YP_852847.1	decatenates replicating daughter chromosomes
YP_852848.1	catalyzes the formation of selenophosphate from selenide and ATP
YP_852850.1	SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane
YP_852851.1	converts asparagine to aspartate and ammonia
YP_852852.1	catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide
YP_852854.1	Z2808
YP_852861.1	this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress
YP_852878.1	Activates fatty acids by binding to coenzyme A
YP_852891.1	hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel
YP_852893.1	membrane protein YebN
YP_852894.1	methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth
YP_852899.1	metalloprotease
YP_852900.1	Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3
YP_852901.1	affects solute and DNA transport through an unknown mechanism
YP_852904.1	in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA
YP_852906.1	Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins
YP_852910.1	3'-5' exonuclease activity on single or double-strand DNA
YP_852911.1	PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues
YP_852913.1	secreted protein; unknown function
YP_852914.1	non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis
YP_852915.1	catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate
YP_852916.1	catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate
YP_852917.1	catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate
YP_852918.1	Represses the expression of the zwf, eda, glp and gap
YP_852919.1	catalyzes the formation of phosphoenolpyruvate from pyruvate
YP_852920.1	Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA
YP_852922.1	yebL precursor; involved in transport of zinc(II) with ZnuA and C
YP_852923.1	involved in transport of zinc(II) with ZnuA and C
YP_852924.1	involved in transport of zinc(II) with ZnuA and C
YP_852925.1	promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration
YP_852926.1	plays an essential role in ATP-dependent branch migration of the Holliday junction
YP_852928.1	endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity
YP_852930.1	converts dATP to dAMP and pyrophosphate
YP_852931.1	catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes
YP_852941.1	catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase
YP_852943.2	membrane protein involved in the flagellar export apparatus
YP_852944.1	membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export
YP_852945.1	cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation
YP_852946.1	chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble
YP_852947.1	regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins
YP_852948.1	methylates the MCP
YP_852951.1	chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component
YP_852952.1	with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
YP_852953.1	With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine
YP_852954.1	With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems
YP_852955.1	with FlhC is involved in the activation of class 2 flagellar genes and is involved in the regulation of a number of other genetic systems
YP_852956.1	ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress
YP_852958.1	biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature
YP_852959.1	Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose
YP_852960.1	Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose
YP_852965.1	cytoplasmic iron storage protein
YP_852968.1	CDP-1,2-diacyl-sn-glycero-3-phosphate phosphatidyl transferase
YP_852969.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision
YP_852970.1	in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system
YP_852971.1	regulates genes involved in cell division
YP_852974.1	catalyzes the formation of pyruvate from D-cysteine
YP_852976.1	expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence
YP_852977.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes
YP_852978.1	structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes
YP_852979.1	involved in flagellin assembly
YP_852980.1	flagellin specific chaperone
YP_852981.1	binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family
YP_852982.1	converts 1,4-alpha-D-glucans to maltodextrin
YP_852988.1	DLP12 prophage; similar to PEBP/RK1P protein family in eukaryotes that inhibits MEK phosphorylation by Raf-1; crystal structure suggests similar properties but exact function is unknown
YP_852989.1	member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation
YP_852990.1	forms a junction between the M-ring and FlgB during flagella biosynthesis
YP_852992.1	One of three proteins involved in switching the direction of the flagellar rotation
YP_852993.1	binds to and inhibits the function of flagella specific ATPase FliI
YP_852994.1	involved in type III protein export during flagellum assembly
YP_852995.1	rod/hook and filament chaperone
YP_852997.1	interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring
YP_852998.1	with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation
YP_852999.1	One of three proteins involved in switching the direction of the flagellar rotation
YP_853000.1	with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus
YP_853001.1	FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus
YP_853002.1	with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus
YP_853003.1	FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus
YP_853007.1	catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate
YP_853016.1	Hsp31 stabilizes early unfolding protein intermediates under severe heat stress
YP_853018.1	induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced
YP_853020.1	reductase; in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ
YP_853021.1	conserved inner membrane protein; in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme
YP_853022.1	conserved metal-binding protein
YP_853032.1	phage-related
YP_853034.1	Gp14
YP_853037.1	Gp11
YP_853038.1	Gp10
YP_853046.1	restriction endonuclase
YP_853070.1	catalyzes the conversion of chorismate to salicylate in the biosynthesis of the siderophore yersiniabactin
YP_853085.1	Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile
YP_853089.1	LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB
YP_853090.1	Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation
YP_853092.1	catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole
YP_853093.1	catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole
YP_853094.1	catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP
YP_853127.1	removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains
YP_853128.1	Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates
YP_853134.1	Antitoxin that counteracts the effect of the YoeB toxin
YP_853135.1	long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors
YP_853136.1	catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer
YP_853137.1	catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis
YP_853138.1	catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate
YP_853139.1	with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide
YP_853140.1	catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide
YP_853141.1	catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase
YP_853142.1	catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis
YP_853145.1	catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate
YP_853149.1	with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose
YP_853150.1	NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose
YP_853151.1	together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose
YP_853152.1	WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid
YP_853156.1	WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid
YP_853163.1	acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit)
YP_853165.2	essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance
YP_853167.1	acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium
YP_853169.1	Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide)
YP_853170.1	Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis
YP_853174.1	YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs
YP_853175.1	Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis
YP_853176.1	functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor
YP_853177.1	contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction
YP_853178.1	inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine
YP_853183.1	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate
YP_853184.1	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate
YP_853185.1	Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate
YP_853188.1	response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport
YP_853206.1	phage-associated
YP_853209.1	cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role
YP_853211.1	Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate
YP_853213.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_853214.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_853216.1	catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway
YP_853217.1	catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate
YP_853223.1	catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine
YP_853224.1	catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP
YP_853225.1	membrane protein conferring nickel and cobalt resistance
YP_853232.1	methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content
YP_853241.1	unknown function; when overproduced it confers drug-resistance
YP_853249.1	component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent
YP_853250.1	specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7
YP_853254.1	may be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
YP_853258.1	Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis
YP_853260.1	function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain
YP_853261.1	catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines
YP_853262.1	ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex
YP_853263.1	with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains
YP_853265.1	negative regulator of the mglBAC operon for galactose utilization
YP_853267.1	involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer
YP_853269.2	Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein
YP_853272.1	Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues
YP_853274.1	Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively
YP_853275.1	activator of nucleoside metabolism
YP_853279.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_853280.1	converts fructose-1-phosphate and ATP to fructose-1,6-bisphosphate and ADP; highly specific for fructose-1-phopshate; similar to PfkB; forms homodimers
YP_853281.1	phosphoenolpyruvate (PEP)-dependent, sugar transporting phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIA is phosphorylated by phospho-HP which then transfers the phosphoryl group to the IIB componentr
YP_853283.1	Stimulates the peptidyltransferase activity of the 70S ribosome and enhances dipeptide synthesis with N-formylmethionyl-tRNA and puromycin in vitro, suggesting its involvement in the formation of the first peptide bond of a protein
YP_853287.1	by similarity, Spr seems to have peptidase activity; involved in thermoresistance
YP_853293.1	Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance
YP_853294.1	catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA
YP_853301.1	nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes
YP_853305.1	CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane
YP_853308.1	ATP-binding protein; required for proper cytochrome c maturation
YP_853309.1	with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone
YP_853310.1	small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA
YP_853311.1	part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA
YP_853312.1	part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway
YP_853313.1	periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC
YP_853315.1	Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA.
YP_853317.1	malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate
YP_853318.1	efflux pump for the antibacterial peptide microcin J25
YP_853321.1	catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway
YP_853322.1	OmpC; allows for ions and hydrophilic solutes to cross the outer membrane
YP_853324.1	two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF
YP_853326.1	with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism
YP_853327.1	with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism
YP_853331.1	authentic frameshift
YP_853332.1	authentic frameshift
YP_853338.1	negatively supercoils closed circular double-stranded DNA
YP_853339.1	Involved in ubiquinone biosynthesis
YP_853341.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_853342.1	B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA
YP_853343.1	plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases
YP_853345.1	hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic
YP_853346.1	catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell
YP_853347.1	anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor
YP_853348.1	sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters
YP_853349.1	anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate
YP_853359.1	catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose
YP_853360.1	catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate
YP_853361.1	Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains
YP_853363.1	catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A
YP_853367.1	catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate
YP_853368.1	catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA
YP_853369.1	catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA
YP_853370.1	SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis
YP_853374.1	member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions
YP_853378.1	Catalyzes the transfer of electrons from NADH to quinone
YP_853379.1	Catalyzes the transfer of electrons from NADH to quinone
YP_853380.1	Catalyzes the transfer of electrons from NADH to ubiquinone
YP_853381.1	Catalyzes the transfer of electrons from NADH to quinone
YP_853382.1	Catalyzes the transfer of electrons from NADH to quinone
YP_853383.1	Catalyzes the transfer of electrons from NADH to quinone
YP_853384.1	Catalyzes the transfer of electrons from NADH to quinone
YP_853385.1	Catalyzes the transfer of electrons from NADH to quinone
YP_853386.1	shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase
YP_853387.1	Catalyzes the transfer of electrons from NADH to quinone
YP_853388.1	NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms
YP_853389.1	The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen
YP_853390.1	Catalyzes the transfer of electrons from NADH to quinone
YP_853393.1	broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor
YP_853399.1	AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA
YP_853406.1	catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate
YP_853414.1	catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate
YP_853415.1	Catalyzes first step of the de novo purine nucleotide biosynthetic pathway
YP_853416.1	membrane protein required for colicin V production
YP_853419.2	catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits
YP_853421.1	mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability
YP_853424.1	in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein
YP_853426.1	FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP
YP_853427.1	catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules
YP_853431.1	D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm
YP_853432.1	catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis
YP_853433.1	involved in methylation of ribosomal protein L3
YP_853439.1	pilus assembly protein
YP_853442.1	multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate
YP_853443.1	FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth
YP_853451.1	phage-associated
YP_853452.1	phage-associated
YP_853453.1	protease
YP_853459.1	phage-associated
YP_853460.1	phage-associated
YP_853461.1	phage-associated
YP_853462.1	phage-associated
YP_853464.1	phage coat protein
YP_853468.1	phage-associated
YP_853469.1	phage-associated
YP_853470.1	phage-associated
YP_853471.1	phage-associated
YP_853472.1	phage-associated
YP_853473.1	cell lysis protein
YP_853474.1	phage-associated
YP_853476.1	phage-associated
YP_853477.1	phage-associated
YP_853479.1	phage-associated
YP_853480.1	phage-associated
YP_853481.1	phage-associated
YP_853484.1	phage-associated
YP_853487.1	phage-associated
YP_853488.1	phage-associated
YP_853489.1	phage-associated
YP_853490.1	phage-associated
YP_853495.1	regulates the synthesis and expression of the dsdXA operon and dadA gene
YP_853496.1	member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function
YP_853497.1	catalyzes the formation of pyruvate from serine
YP_853500.1	response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance
YP_853503.1	member of the AEC family of auxin efflux transporters; unknown function
YP_853504.1	catalyzes the formation of formyl-CoA from oxalyl-CoA
YP_853505.1	catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA
YP_853508.1	Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock
YP_853514.1	peptidase; metalloprotein
YP_853515.1	Xaa-Pro aminopeptidase; limited methionine aminopeptidase
YP_853518.1	catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate
YP_853523.1	ELA domain
YP_853526.1	Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation
YP_853529.1	catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation
YP_853530.1	sugar hydrolase
YP_853532.1	this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB
YP_853533.1	interacts with cell division protein FitsZ and may be required to anchor septal ring structure
YP_853534.1	role in sulfur assimilation
YP_853535.1	CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis
YP_853537.1	Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system
YP_853538.1	functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose
YP_853539.1	catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal
YP_853541.1	catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide
YP_853543.1	Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import
YP_853547.1	catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway
YP_853548.1	belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component
YP_853554.1	catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis
YP_853555.1	activates the transcription of the ethanolamine utilization operon
YP_853558.1	catalyzes the formation of acetaldehyde from ethanolamine
YP_853560.1	ethanolamine utilization protein EutA
YP_853563.1	chaperonin
YP_853567.1	ethanolamine utilization; in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta
YP_853572.1	NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate
YP_853574.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_853577.1	unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic)
YP_853578.1	nitrate/nitrite sensor protein
YP_853581.1	dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica.
YP_853582.1	Displays esterase activity toward palmitoyl-CoA and pNP-butyrate
YP_853583.1	hydrolase
YP_853584.1	metalloprotease
YP_853585.1	catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase
YP_853587.1	catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis
YP_853588.1	negative transcriptional regulator of the gcvTHP operon
YP_853589.1	bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine
YP_853593.1	controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP
YP_853595.1	Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate
YP_853596.1	catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis
YP_853597.1	glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate
YP_853598.1	catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate
YP_853600.1	inner membrane protein
YP_853605.1	phage-associated
YP_853607.1	phage-associated
YP_853608.1	similar to endo-N-acetylneuraminidase
YP_853609.1	phage-associated
YP_853610.1	phage-associated
YP_853612.1	phage-associated
YP_853613.1	phage-associated
YP_853614.1	phage-associated
YP_853615.1	phage-associated
YP_853616.1	phage-associated
YP_853617.1	phage-associated
YP_853618.1	phage-associated
YP_853619.1	phage-associated
YP_853620.1	phage-associated
YP_853621.1	phage-associated
YP_853622.1	phage-associated
YP_853623.1	phage-associated
YP_853624.1	phage-associated
YP_853625.1	phage-associated
YP_853627.1	phage-associated
YP_853630.1	phage-associated
YP_853631.1	phage-associated
YP_853632.1	phage-associated
YP_853633.1	phage-associated
YP_853634.1	phage-associated
YP_853635.1	phage-associated
YP_853640.1	phage-associated
YP_853641.1	phage recombinase
YP_853644.1	phage-associated
YP_853645.1	diadenosine tetraphosphatase and related serine/threonine protein phosphatases COG
YP_853646.1	phage-associated
YP_853647.1	contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway
YP_853648.1	catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate
YP_853649.1	bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides
YP_853653.1	EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains
YP_853654.1	with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis
YP_853656.1	catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG
YP_853657.1	catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis
YP_853659.1	23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance
YP_853660.1	catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate
YP_853661.1	penicillin-insensitive transglycosylase/transpeptidase
YP_853663.1	catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds
YP_853664.1	enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I
YP_853665.1	catalyzes the removal of an N-terminal amino acid from a peptide or arylamide
YP_853667.1	involved in the maturation of iron-sulfur cluster-containing proteins
YP_853668.1	J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins
YP_853669.1	forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein
YP_853671.1	catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis
YP_853672.1	regulates the expression of the iscRSUA operon
YP_853677.1	transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters
YP_853684.1	TPR repeat domain
YP_853686.1	catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate
YP_853687.1	flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine
YP_853688.1	indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA
YP_853692.1	catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis
YP_853693.1	YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function
YP_853697.1	Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids
YP_853698.1	involved in the de novo synthesis of pyridoxine (Vitamin B6)
YP_853699.1	involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA
YP_853700.1	Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome
YP_853701.1	cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity
YP_853702.1	catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins
YP_853703.1	binds to the ribosome on the universally-conserved alpha-sarcin loop
YP_853704.1	involved in the reduction of the SoxR iron-sulfur cluster
YP_853705.1	periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP
YP_853707.1	Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response
YP_853708.1	catalyzes the formation of oxaloacetate from L-aspartate
YP_853710.1	facilitates an early step in the assembly of the 50S subunit of the ribosome
YP_853713.1	stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit
YP_853714.1	Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine
YP_853720.1	catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome
YP_853729.1	chaperone
YP_853731.1	responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA
YP_853732.1	with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline
YP_853733.1	catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis
YP_853734.1	catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis
YP_853735.2	catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive
YP_853740.1	this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site
YP_853743.1	Essential for efficient processing of 16S rRNA
YP_853744.1	binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity
YP_853745.1	with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins
YP_853746.1	inner membrane protein
YP_853749.1	catalyzes the phosphorylation of NAD to NADP
YP_853753.1	binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation
YP_853761.1	phage-associated
YP_853762.1	phage-associated
YP_853770.1	phage-associated
YP_853772.1	phage-associated
YP_853773.1	phage-associated
YP_853775.1	phage-associated
YP_853783.1	phage-associated
YP_853784.1	phage-associated
YP_853785.1	phage-associated
YP_853786.1	phage-associated
YP_853787.1	phage-associated
YP_853788.1	phage-associated
YP_853789.1	phage-associated
YP_853790.1	phage-associated
YP_853791.1	phage-associated
YP_853792.1	phage-associated
YP_853793.1	phage-associated
YP_853794.1	phage-associated
YP_853795.1	phage-associated
YP_853796.1	phage-associated
YP_853797.1	phage-associated
YP_853808.1	in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution
YP_853809.1	dehydrogenase; catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate
YP_853810.1	catalyzes the formation of succinate from succinate semialdehyde; NADP dependent
YP_853811.1	catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate
YP_853813.1	regulator of gab gene expression
YP_853850.1	in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF
YP_853851.1	Catalyzes the rate-limiting step in dNTP synthesis
YP_853853.1	B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE
YP_853854.1	with ProWX is involved in the high-affinity uptake of glycine betaine
YP_853857.1	with ProVX is involved in the high-affinity uptake of glycine betaine
YP_853858.1	with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine
YP_853870.1	DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB
YP_853882.1	catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2
YP_853912.1	involved in the first step of glutathione biosynthesis
YP_853914.1	YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent
YP_853916.1	Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_853917.1	binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities
YP_853918.1	catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs
YP_853920.1	membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan
YP_853923.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_853924.1	catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate
YP_853925.1	regulator for glucitol utilization
YP_853926.1	regulates genes involved in glucitol utilization
YP_853927.1	catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate
YP_853928.1	Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon
YP_853929.1	detoxifies nitric oxide using NADH
YP_853930.1	catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase
YP_853932.1	involved in electron transport from formate to hydrogen
YP_853934.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_853937.1	involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE
YP_853940.1	electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate
YP_853943.1	catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3)
YP_853945.1	regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon
YP_853946.1	plays a role in hydrogenase nickel cofactor insertion
YP_853947.1	GTP hydrolase involved in nickel liganding into hydrogenases
YP_853948.1	HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase
YP_853954.1	This protein performs the mismatch recognition step during the DNA repair process
YP_853959.1	sugar aldolase
YP_853961.1	Zn-dependent hydrolase; member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function
YP_853962.1	Zn-dependent hydrolase
YP_853964.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses
YP_853965.1	outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus
YP_853966.1	catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins
YP_853967.1	catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate
YP_853968.1	catalyzes the modification of U13 in tRNA(Glu)
YP_853969.1	catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate
YP_853970.1	4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers
YP_853971.1	forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein
YP_853973.1	converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis
YP_853974.1	may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ
YP_853975.1	with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP
YP_853976.1	catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3
YP_853977.1	catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite
YP_853978.1	hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide
YP_853979.1	catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity
YP_853996.1	enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis
YP_853997.1	CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer
YP_853998.1	functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era
YP_853999.1	MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system
YP_854000.1	(p)ppGpp synthetase; catalyzes the formation of pppGpp and ppGpp from ATP and GTP or GDP
YP_854001.1	in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S]
YP_854002.1	part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system
YP_854006.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_854007.1	catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp
YP_854010.1	catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis
YP_854016.1	catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate
YP_854018.1	catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose
YP_854021.1	regulates expression of genes involved in L-fucose utilization
YP_854024.1	Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence
YP_854028.2	membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues
YP_854059.1	catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis
YP_854060.1	helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity
YP_854061.1	helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity
YP_854063.1	catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination
YP_854067.1	type II secretory pathway, pseudopilin
YP_854068.1	ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived
YP_854069.1	transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein
YP_854070.1	member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr
YP_854072.1	MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair
YP_854073.1	possibly involved in tellurite resistance
YP_854074.1	complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH
YP_854076.1	Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1
YP_854077.1	controls transcription of galETKM
YP_854078.1	catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding
YP_854079.1	activates the transcription of the lysA gene encoding diaminopimelate decarboxylase
YP_854080.1	Asp/Glu/Hydantoin racemase family
YP_854082.1	catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate
YP_854083.1	4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate
YP_854084.1	thiolase domain; Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis
YP_854087.1	aldehyde oxidase and xanthine dehydrogenase, molybdopterin binding domain; molybdenum cofactor-binding protein; participates in purine salvage
YP_854088.1	FAD-binding subunit; with XdhA and XdhC participates in purine salvage
YP_854089.1	regulatory protein
YP_854090.1	aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain
YP_854091.1	catalyzes the formation of pyruvate from 2,3-diaminopropionate
YP_854092.1	Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases
YP_854093.1	catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position
YP_854094.1	catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP
YP_854098.1	with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase
YP_854099.1	in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS
YP_854100.1	with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain
YP_854101.1	with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration
YP_854103.1	Catalyzes the deamination of guanine
YP_854106.1	unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic)
YP_854108.1	catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate
YP_854109.1	class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_854111.1	5'-3' single-stranded-DNA-specific exonuclease
YP_854112.1	DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity
YP_854114.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic
YP_854117.1	physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator
YP_854121.1	acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine
YP_854122.1	part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor
YP_854123.2	catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein
YP_854125.1	Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone
YP_854126.1	exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide
YP_854127.2	the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown
YP_854129.2	ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function
YP_854130.1	catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate
YP_854131.1	Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway
YP_854132.2	specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport
YP_854136.1	Involved in the export of arginine
YP_854137.1	participates in the regulation of osmotic pressure changes within the cel
YP_854138.1	catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate
YP_854139.1	Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway
YP_854140.1	NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate
YP_854150.1	TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein
YP_854152.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_854154.1	catalyzes the formation of putrescine from agmatine
YP_854156.1	catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis
YP_854157.1	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_854161.1	in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase
YP_854162.1	catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione
YP_854164.1	similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function
YP_854169.1	HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine
YP_854170.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_854172.1	catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis
YP_854175.1	tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine
YP_854206.1	Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues
YP_854214.1	integrase core domain
YP_854248.1	allele II
YP_854257.1	fimbrial regulatory protein
YP_854275.1	similar to transcriptional regulator
YP_854314.1	iron-responsive element (ireA); ireA gene is located on pathogenicity island I (PAI I); outer membrane protein
YP_854332.1	CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS
YP_854399.2	similar to general secretory pathway protein L
YP_854408.1	part of the general (type II) secretion pathway (GSP), a signal sequence-dependent process responsible for protein export; involved in trans-location of exoproteins from the cytoplasm to the periplasm
YP_854448.1	catalyzes the formation of malate from glyoxylate and acetyl-CoA
YP_854454.1	activates fatty acids by binding to coenzyme A
YP_854456.1	7-keto-8-aminopelargonate synthetase and related enzymes family
YP_854466.1	catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction
YP_854467.1	YghU; B2989; one of eight  glutathione transferase proteins from E. coli
YP_854468.1	plays a role in hydrogenase nickel cofactor insertion
YP_854481.1	protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC)
YP_854500.1	involved in hydrogen uptake
YP_854501.1	HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits
YP_854502.1	Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2
YP_854503.1	involved in hydrogen uptake
YP_854509.1	membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell
YP_854510.1	membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell
YP_854511.1	catalyzes the formation of L-homocysteine from cystathionine
YP_854515.1	methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate
YP_854531.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_854541.1	YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system
YP_854614.1	response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes
YP_854666.1	decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling
YP_854670.1	Displays esterase activity toward palmitoyl-CoA and pNP-butyrate
YP_854822.1	ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose
YP_854844.1	trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell
YP_854981.1	seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine
YP_855141.1	DHBP synthase; functions during riboflavin biosynthesis
YP_855187.1	catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose
YP_855254.1	catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme
YP_855260.1	catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases
YP_855309.1	BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell
YP_855325.1	catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin
YP_855413.1	involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX
YP_855415.1	activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol
YP_855419.1	Involved in the tartrate degradation pathway
YP_855432.1	Involved in the tartrate degradation pathway
YP_855494.1	in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity
YP_855495.1	synthesizes RNA primers at the replication forks
YP_855524.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria
YP_858707.1	catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate
YP_858710.1	in Escherichia coli this is the second beta-galactosidase system
YP_858711.1	in Escherichia coli this is the second beta-galactosidase system
YP_858720.1	involved in the import of serine and threonine coupled with the import of sodium
YP_858723.1	catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism
YP_858725.1	regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization.
YP_858741.1	catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism
YP_858742.1	involved in the import of threonine and serine in combination with the import of a proton
YP_858743.1	catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic
YP_858744.1	regulates the tdcABCDEFG operon which is involved in amino acid degradation
YP_858745.1	participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon
YP_858748.1	catalyzes the reduction of tartronate semialdehyde to glycerate
YP_858749.1	cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate
YP_858752.1	transcriptional repressor for the agaZVWA and agaSYBCDI operons
YP_858754.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport
YP_858760.1	catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway
YP_858761.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport
YP_858762.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport
YP_858763.1	catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport
YP_858768.1	Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein
YP_858769.1	periplasmic protein
YP_858780.1	tryptophan transporter of high affinity
YP_858781.1	participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division
YP_858782.1	lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing
YP_858784.1	primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence
YP_858785.1	catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs
YP_858786.1	associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock
YP_858787.1	Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex
YP_858788.1	modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination
YP_858789.2	in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins
YP_858790.1	catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis
YP_858793.1	catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate
YP_858794.1	catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate
YP_858795.1	inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins
YP_858796.1	Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit
YP_858798.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_858799.1	penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains
YP_858800.1	essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication
YP_858804.1	regulatory factor of maltose metabolism; activator of maltose metabolism genes
YP_858805.1	adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active
YP_858810.1	ATP-binding subunit of a  ABC toluene efflux transporter
YP_858811.1	YrbG; inner membrane protein involved in cell envelope integrity; sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers
YP_858813.1	forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis
YP_858815.1	LptA; periplasmic binding protein part of a  ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system
YP_858817.1	sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen
YP_858818.1	YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing
YP_858823.1	glycosyltransferase; polymerizes glycan strands in the peptidoglycan
YP_858825.1	sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA
YP_858827.1	catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate
YP_858828.1	glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate
YP_858830.1	catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein
YP_858831.1	Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate
YP_858833.1	catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid
YP_858834.1	Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization
YP_858836.1	transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation
YP_858837.1	forms a direct contact with the tRNA during translation
YP_858838.1	in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit
YP_858839.1	ATPase function
YP_858843.1	oxidizes malate to oxaloacetate
YP_858844.1	regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes
YP_858847.1	with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate
YP_858848.1	with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate
YP_858849.2	membrane protein AaeX; the gene is a member of the aaeXAB operon
YP_858851.1	responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA
YP_858853.1	involved in the processing of the 5'end of 16S rRNA
YP_858854.1	Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell
YP_858855.1	part of cell wall structural complex MreBCD; transmembrane component
YP_858856.1	in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall
YP_858857.1	functions in MreBCD complex in some organisms
YP_858858.1	regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules
YP_858860.1	composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_858861.1	an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism
YP_858867.1	catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway
YP_858872.1	mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase
YP_858873.1	methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype
YP_858875.1	Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription
YP_858887.1	AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate
YP_858888.1	RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA
YP_858892.1	cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+)
YP_858893.1	modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth
YP_858894.1	catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase
YP_858895.1	involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain
YP_858896.1	forms homopentamer; channel that opens in response to pressure or hypoosmotic shock
YP_858897.1	mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators
YP_858899.1	is a component of the macrolide binding site in the peptidyl transferase center
YP_858900.1	catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme
YP_858901.1	primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination
YP_858902.1	located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3
YP_858903.1	located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA
YP_858904.1	forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase
YP_858905.1	late assembly protein
YP_858906.1	located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance
YP_858907.1	binds 5S rRNA along with protein L5 and L25
YP_858908.1	ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance
YP_858909.1	binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit
YP_858910.1	located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif
YP_858911.1	part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13
YP_858912.1	assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel
YP_858913.1	binds to the 23S rRNA between the centers for peptidyl transferase and GTPase
YP_858914.1	primary binding protein; helps mediate assembly; involved in translation fidelity
YP_858915.1	located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e
YP_858916.1	forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation
YP_858917.1	binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center
YP_858918.1	protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA
YP_858919.1	one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation
YP_858920.1	L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA
YP_858921.1	binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin
YP_858922.1	NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex
YP_858938.1	iron storage protein
YP_858940.2	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_858941.1	EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene
YP_858942.1	binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit
YP_858943.1	interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance
YP_858944.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_858945.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_858946.1	in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs
YP_858948.1	rotamase
YP_858949.1	rotamase
YP_858950.1	involved in potassium efflux
YP_858951.1	required for KefB activity
YP_858956.1	complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons
YP_858957.1	integral membrane protein
YP_858958.1	DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate
YP_858959.1	aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity
YP_858964.1	involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations
YP_858965.1	member of the FNT family of formate and nitrite transporters
YP_858966.1	multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin
YP_858970.1	phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE)
YP_858975.1	catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA
YP_858976.1	catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate
YP_858977.1	catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate
YP_858980.1	catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis
YP_858981.2	type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis
YP_858982.1	outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa
YP_858986.2	bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits
YP_858987.1	ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose
YP_858991.1	becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers
YP_858993.1	PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP
YP_858994.1	membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR
YP_858995.1	part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation
YP_858996.1	necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus
YP_858998.1	cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake
YP_859000.1	Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis
YP_859001.1	involved in high-affinity gluconate transport
YP_859002.1	cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source
YP_859004.1	amylomaltase; acts to release glucose from maltodextrins
YP_859006.1	Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides
YP_859007.1	catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester
YP_859010.1	represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism
YP_859011.1	protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity
YP_859012.1	belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine
YP_859013.1	in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane
YP_859026.1	catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose
YP_859027.1	catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate
YP_859028.1	catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen
YP_859029.1	catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain
YP_859030.1	catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde
YP_859031.1	YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP)
YP_859033.1	thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate
YP_859038.1	YhhY; regulated by the fur regulator; unknown function
YP_859042.1	periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides
YP_859044.1	hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate
YP_859045.1	part of the UgpABCE glycerol-3-phosphate uptake system
YP_859046.1	with UgpABC is involved in uptake of glycerol-3-phosphate
YP_859047.1	with UgpEC is involved in the uptake of glycerol-3-phosphate
YP_859048.1	with UgpACE is involved in the uptake of glycerol-3-phosphate
YP_859049.1	with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_859050.1	Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_859051.1	Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine
YP_859052.1	LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter
YP_859056.1	PTS system component
YP_859057.1	PTS system component
YP_859059.1	phosphotransferase system enzyme II
YP_859060.1	similar to D-3-phosphoglycerate dehydrogenase
YP_859062.1	binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters
YP_859063.1	ABC transporter membrane protein
YP_859064.1	ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions
YP_859065.1	signal recognition protein receptor; functions in the targeting and insertion of membrane proteins
YP_859066.1	catalyzes the methylation of 16S rRNA at position G966
YP_859068.1	inner membrane protein
YP_859069.1	P-type ATPase involved in the export of lead, cadmium, zinc and mercury
YP_859077.1	with NikACDE is involved in nickel transport into the cell
YP_859078.1	with NikABDE is involved in nickel transport into the cell
YP_859079.1	with NikABCE is involved in nickel transport into the cell
YP_859080.1	with NikABCD is involved with nickel transport into the cell
YP_859081.1	Inhibits transcription at high concentrations of nickel
YP_859088.1	class II aldolase; catalyzes the reversible aldol condensation of dihydroxyacetonephosphate and glyceraldehyde 3-phosphate in the Calvin cycle, glycolysis and gluconeogenesis
YP_859095.1	ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress
YP_859097.1	member of the POT family of peptide transporters; probable proton-dependent peptide transporter function
YP_859098.1	predicted SAM-dependent methyltransferase
YP_859101.1	catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense
YP_859108.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_859112.1	with HmuTU is involved in the transport of hemin
YP_859113.1	inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli
YP_859115.1	inactive form
YP_859119.1	with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds
YP_859122.1	regulates genes in response to acid and/or during stationary phase
YP_859125.1	cytoplasmic; catalyzes the hydrolysis of trehalose to glucose
YP_859131.1	in Escherichia coli this protein is involved in flagellar function
YP_859134.1	involved in the transport of C4-dicarboxylates across the membrane
YP_859135.1	HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a  phosphodiesterase protein from E. coli
YP_859136.1	cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA
YP_859137.1	catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans
YP_859138.1	binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP)
YP_859139.1	polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis
YP_859142.1	inner membrane protein
YP_859147.1	Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides
YP_859148.1	DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF
YP_859150.1	transports peptides consisting of two or three amino acids
YP_859153.1	catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide
YP_859154.1	permease
YP_859156.2	constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine
YP_859159.1	lipoprotein
YP_859164.1	glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_859165.1	glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_859166.1	lipoprotein
YP_859169.1	inner membrane protein
YP_859171.2	catalyzes the interconversion of D-xylose to D-xylulose
YP_859172.1	periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity
YP_859173.2	with XylFH is part of the high affinity xylose ABC transporter
YP_859177.1	periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds
YP_859178.1	transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis
YP_859181.1	oxidoreductase; NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate
YP_859184.1	YiaN-like
YP_859187.1	3-hexulose-6-phosphate synthase; catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate
YP_859188.1	L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate
YP_859194.1	catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis
YP_859197.1	inner membrane protein
YP_859200.1	Acts as a repressor of the mtlAD operon
YP_859205.1	represses the lctPRD operon
YP_859206.1	flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration
YP_859207.1	member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates
YP_859208.1	catalyzes the O-acetylation of serine
YP_859209.1	catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate
YP_859210.1	molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA
YP_859213.1	catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate
YP_859217.1	converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism
YP_859218.1	catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine
YP_859219.1	catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose
YP_859220.1	catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core
YP_859231.1	catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A
YP_859232.1	Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases
YP_859233.1	Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase
YP_859234.2	catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine
YP_859235.1	catalyzes the formation of dUMP from dUTP
YP_859236.1	FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly
YP_859237.1	involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate
YP_859238.1	RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs
YP_859239.1	alpha-helix protein
YP_859242.1	LigB; this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+
YP_859243.1	Essential for recycling GMP and indirectly, cGMP
YP_859244.1	promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits
YP_859246.1	specifically modifies tRNA at position G18
YP_859247.1	catalyzes branch migration in Holliday junction intermediates
YP_859259.1	catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides
YP_859260.1	may be involved in the transport of galactosides-pentoses-hexuronides
YP_859261.1	virulence protein RhuM
YP_859266.2	experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS
YP_859267.1	2-methylthioadenine synthetase
YP_859269.1	catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type
YP_859270.1	cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate
YP_859271.1	membrane protein regulates uhpT expression
YP_859272.1	Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph
YP_859273.1	response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter
YP_859274.1	with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit
YP_859277.1	multidrug efflux protein involved in adaptation to low energy shock
YP_859282.1	uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function
YP_859285.2	16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent
YP_859286.1	with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress
YP_859289.1	dehydrogenase; FAD/NAD(P)-binding domain
YP_859292.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism
YP_859296.1	YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins
YP_859298.1	negatively supercoils closed circular double-stranded DNA
YP_859299.1	RecF, a recombinational DNA repair ATPase; Required for DNA replication; binds preferentially to single-stranded, linear DNA
YP_859300.1	binds the polymerase to DNA and acts as a sliding clamp
YP_859301.1	binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself.
YP_859302.1	protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates
YP_859303.1	functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria
YP_859304.1	in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE
YP_859305.1	tryptophan deaminase, PLP-dependent; tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan
YP_859306.1	tryptophan transporter of low affinity
YP_859307.1	drug/chloramphenicol transport protein (MFS family); Confers resistance to chloramphenicol
YP_859308.1	predicted DNA-binding transcriptional regulator; Involved in anaerobic NO protection
YP_859309.1	predicted phosphopantetheinyl transferase
YP_859312.1	YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily
YP_859313.1	might be involved in hypersensitivity to nitrofurzone
YP_859314.1	isomerase-like
YP_859318.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_859319.1	positive regulator of the beta-glucoside operon; transcriptional antiterminator
YP_859320.1	regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon
YP_859321.1	ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation
YP_859322.1	Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions
YP_859323.1	part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions
YP_859324.1	periplasmic-binding component of ABC superfamily
YP_859325.1	GlmS; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source
YP_859326.1	GlmU; forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis
YP_859328.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit
YP_859329.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit
YP_859332.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0
YP_859333.1	Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation
YP_859334.1	glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA
YP_859335.1	GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs
YP_859336.1	An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group
YP_859337.1	transcriptional repressor of asnA which codes for aspartate-ammonia ligase
YP_859338.1	catalyzes the formation of asparagine from aspartate and ammonia
YP_859339.1	predicted von Willibrand factor-containing protein; contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA
YP_859340.1	interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase
YP_859341.1	Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH
YP_859342.2	cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source
YP_859343.1	with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain
YP_859344.1	functions to transport ribose at high affinity; forms a complex with RbsA2C2B
YP_859345.1	periplasmic substrate-binding component of the ATP-dependent ribose transport system
YP_859346.1	catalyzes the formation of D-ribose 5-phosphate from ribose
YP_859347.1	DNA-binding transcriptional repressor of ribose metabolism
YP_859351.1	Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon
YP_859353.1	among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function
YP_859354.1	catalyzes the formation of 2-acetolactate from pyruvate; also known as acetolactate synthase large subunit
YP_859356.1	catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids
YP_859357.1	catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis
YP_859358.1	threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway
YP_859359.1	DNA-binding transcriptional dual regulator; participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate
YP_859360.1	catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis
YP_859362.1	single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication
YP_859363.1	catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation
YP_859364.1	enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation
YP_859366.1	An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes
YP_859368.1	Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein
YP_859370.1	catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid
YP_859372.1	glucose-1-phosphate thymidylyltransferase
YP_859374.1	catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis
YP_859376.1	catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis
YP_859377.1	enterobacterial common antigen polymerase
YP_859379.1	uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function
YP_859384.1	catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis
YP_859385.1	transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis
YP_859386.2	catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP
YP_859387.1	defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly
YP_859391.1	involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate
YP_859393.1	site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs
YP_859394.1	YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function
YP_859395.1	unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair.
YP_859398.1	responsible for the influx of magnesium ions
YP_859403.1	catalyzes the hydrolysis of phosphatidylcholine
YP_859404.1	functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway
YP_859407.1	lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates
YP_859408.1	purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium
YP_859410.1	regulator for metE and metH
YP_859411.1	catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine
YP_859417.1	catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase
YP_859422.2	catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP
YP_859428.1	catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway
YP_859435.1	YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner
YP_859436.1	Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone
YP_859438.1	an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions
YP_859439.1	TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes
YP_859440.1	mediates the export of protein precursors bearing twin-arginine signal peptides
YP_859441.1	with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane
YP_859442.1	magnesium dependent; not involved in the Sec-independent protein export system
YP_859444.1	catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol
YP_859445.1	NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin
YP_859446.1	FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids
YP_859447.1	includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids
YP_859448.1	catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters
YP_859451.1	catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX
YP_859453.1	in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway
YP_859454.1	in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis
YP_859456.1	catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages
YP_859460.1	has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair
YP_859461.1	binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential
YP_859463.1	catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III
YP_859464.1	response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54
YP_859465.1	sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation
YP_859466.1	forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme
YP_859468.1	similar to DNA-binding transcriptional regulator YihW
YP_859469.1	similar to ribokinase YihV; ribokinase family
YP_859470.1	similar to oxidoreductase YihU
YP_859473.1	major facilitator superfamily
YP_859474.1	major facilitator superfamily
YP_859476.1	hydrolase
YP_859477.1	RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease
YP_859478.1	hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine
YP_859480.1	esterase/lipase/thioesterase domain
YP_859484.1	required for the formation of active formate dehydrogenase
YP_859485.1	cytochrome b556(FDO) component; heme containing
YP_859487.1	authentic frameshift, identical to Escherichia coli UTI89
YP_859488.1	authentic frameshift, identical to Escherichia coli UTI89
YP_859489.1	involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth
YP_859491.1	porin domain
YP_859492.1	L-rhamnose mutarotase
YP_859494.1	catalyzes the formation of L-rhamnulose from L-rhamnose
YP_859495.1	catalyzes the ATP-dependent phosphorylation of rhamnulose
YP_859496.1	activates the expression of the rhaBAD operon and rhaT gene
YP_859497.1	activates the expression of rhaRS in response to L-rhamnose
YP_859498.1	transports L-rhamnose and L-lyxose into the cell
YP_859499.1	SodA; manganese binding; only present under aerobic conditions; destroys free radicals
YP_859500.2	transports degraded pectin products into the bacterial cell
YP_859502.1	CpxA controls the expression of genes involved in protein folding and degradation; part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors
YP_859503.1	CpxR controls the expression of genes involved in protein folding and degradation, DNA-binding response regulator in two-component regulatory system with CpxA; response regulator in two-component regulatory system with CpxA; part of the envelope stress response system
YP_859504.1	periplasmic protein combats stress; repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates
YP_859505.1	transport function, CDF family; member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers
YP_859506.1	catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis
YP_859509.1	Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate
YP_859513.1	with UspC and Usp E is involved in resistance to UV radiation
YP_859515.1	type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese
YP_859516.1	Converts glycerol and ADP to glycerol-3-phosphate and ADP
YP_859519.1	catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate
YP_859520.1	heat shock protein, homologous to chaperones; heat shock protein involved in degradation of misfolded proteins
YP_859521.1	heat shock protein involved in degradation of misfolded proteins
YP_859523.1	regulator for deo operon, udp, cdd, tsx, nupC, and nupG; negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins
YP_859524.1	primosomal protein N' (factor Y) directs replication fork assembly at D-loops, ATP-dependent; binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity
YP_859525.1	member of the NlpC/P60 superfamily of peptidases
YP_859526.1	repressor of all met genes but metF; when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis
YP_859527.1	catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine
YP_859528.1	multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways
YP_859530.1	metallophosphoesterase
YP_859531.1	dihydroorotase
YP_859534.1	MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor
YP_859538.1	forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone
YP_859539.1	similar to transaldolase from Escherichia coli; many organisms have multiple copies
YP_859540.1	PTS family Hpr
YP_859541.1	FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site
YP_859543.1	involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein
YP_859545.2	FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog
YP_859547.1	sulfatase
YP_859548.1	catalyzes the formation of oxaloacetate from phosphoenolpyruvate
YP_859549.1	catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis
YP_859550.1	catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate
YP_859551.1	catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate
YP_859552.1	catalyzes the formation of arginine from (N-L-arginino)succinate
YP_859554.1	major facilitator superfamily
YP_859555.1	Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA
YP_859556.1	catalyzes the conversion of NADPH to NADH
YP_859559.1	negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis
YP_859561.1	catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs
YP_859562.2	involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space
YP_859563.2	converts L-glutamate to D-glutamate, a component of peptidoglycan
YP_859564.1	catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis
YP_859565.1	biotin ligase; catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon
YP_859566.1	catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis
YP_859567.1	EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu
YP_859568.1	forms a complex with SecY and SecG; SecYEG forms a protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force
YP_859569.1	Modulates Rho-dependent transcription termination
YP_859571.1	binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit
YP_859573.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme
YP_859574.1	DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter
YP_859575.1	in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center
YP_859576.2	functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate
YP_859578.1	catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate
YP_859579.1	required for the synthesis of the hydromethylpyrimidine moiety of thiamine
YP_859580.1	Regulator of RNA polymerase sigma(70) subunit, Rsd/AlgQ; binds specifically to the major sigma factor sigma 70; active in stationary phase
YP_859581.1	can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates
YP_859582.1	catalyzes the formation of coproporphyrinogen from uroporphyrinogen III
YP_859583.1	Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures
YP_859585.1	histone-like DNA-binding protein
YP_859589.1	DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein
YP_859590.1	catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis
YP_859591.1	purine biosynthesis; involved in de novo purine biosynthesis
YP_859596.1	acetyltransferase (GNAT) family
YP_859597.1	acyltransferase activity; catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis
YP_859598.1	Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle
YP_859600.1	catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol
YP_859601.1	bacterial regulatory protein; regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase
YP_859602.1	one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity
YP_859606.1	alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family
YP_859612.1	Converts D-sorbitol-dphosphate to D-fructose-6-phosphate
YP_859614.1	catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA
YP_859616.1	catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive
YP_859617.1	functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family
YP_859624.1	with MalKFE is involved in the transport of maltose into the cell
YP_859625.1	with MalKGE is involved in maltose transport into the cell
YP_859626.1	functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis
YP_859627.1	with malEFG is involved in import of maltose/maltodextrin
YP_859628.1	porin involved in the transport of maltose and maltodextrins
YP_859630.1	catalyzes the formation of 4-hydroxybenzoate from chorismate
YP_859631.1	catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway
YP_859632.1	PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA
YP_859634.1	Represses a number of genes involved in the response to DNA damage
YP_859636.1	Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB
YP_859638.1	coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia
YP_859645.1	unwinds double stranded DNA
YP_859646.1	converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer
YP_859649.1	catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate
YP_859650.1	SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide
YP_859659.1	Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity
YP_859662.1	The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate
YP_859663.2	binds to single stranded DNA and PriA helcase facilitate replication restart
YP_859672.1	member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake
YP_859674.1	Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA
YP_859675.1	catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552
YP_859676.1	part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia
YP_859679.1	with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552
YP_859681.1	carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system
YP_859688.1	authentic frameshift, identical to Escherichia coli UTI89
YP_859689.1	authentic frameshift, identical to Escherichia coli UTI89
YP_859690.1	part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family
YP_859691.1	possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
YP_859692.1	with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride
YP_859698.1	with AlsBC acts to import allose into the cell; AlsA contain 2 ATP-binding domains
YP_859700.1	involved in rpiB and als operon repression
YP_859701.1	catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity
YP_859703.1	required for the use of phosphonates and phosphite as phosphorus sources
YP_859704.1	PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role
YP_859713.1	may be involved in phosphonate uptake and biodegradation
YP_859723.1	response regulator in two-component regulatory system with BasS
YP_859724.1	with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division
YP_859732.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters
YP_859733.1	response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration
YP_859734.1	C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration
YP_859737.1	class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1
YP_859740.1	antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein
YP_859741.1	regulates the cadBA operon
YP_859759.2	catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase
YP_859763.1	reverse trasncriptase-like protein
YP_859764.1	reverse trasncriptase-like protein
YP_859773.1	catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism
YP_859794.1	iso-InsB
YP_859795.1	iso-InsA
YP_859800.1	IS1 transposase
YP_859802.1	integrase-like protein
YP_859804.1	IS1 transposase
YP_859809.1	two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm
YP_859810.1	functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB
YP_859811.1	catalyzes the formation of fumarate from aspartate
YP_859812.1	F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein
YP_859813.1	uncharacterized member of the APC superfamily of amino acid transporters; unknown function
YP_859815.1	60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_859819.1	Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA
YP_859820.1	member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations
YP_859821.1	lipocalin; globomycin-sensitive outer membrane lipoprotein
YP_859823.1	in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane
YP_859824.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_859825.2	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_859826.1	part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB
YP_859827.1	lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA
YP_859833.1	EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity
YP_859834.2	3'-5' exoribonuclease specific for small oligoribonuclotides
YP_859838.1	possibly involved in cell wall synthesis
YP_859840.1	This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex
YP_859841.1	IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity
YP_859842.1	Stimulates the elongation of poly(A) tails
YP_859843.1	involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein
YP_859844.1	with HflC inhibits proteolysis of lambda cII protein by FtsH
YP_859845.1	with HflK inhibits proteolysis of lambda cII protein by FtsH
YP_859846.1	catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis
YP_859847.1	negatively regulates the transcription of genes upregulated by nitrosative stress
YP_859848.1	3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs
YP_859849.1	Specifically methylates the ribose of guanosine 2251 in 23S rRNA
YP_859856.1	catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA
YP_859858.1	in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility
YP_859859.1	YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo
YP_859860.1	negative regulator of ulaG and ulaABCDEF
YP_859862.2	membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr
YP_859865.2	catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization
YP_859866.1	UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway
YP_859867.1	catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source
YP_859869.1	binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21
YP_859870.1	binds single-stranded DNA at the primosome assembly site
YP_859871.1	in Escherichia coli this protein is wrapped around the base of the L1 stalk
YP_859879.2	catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis
YP_859882.1	FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides
YP_859883.1	involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine
YP_859884.1	Involved in anaerobic NO protection and iron metabolism
YP_859888.1	periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate
YP_859889.1	catalyzes the formation of AMP from adenosine-3',5'-bisphosphate
YP_859892.1	this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress
YP_859896.1	catalyzes the hydrolysis of pyrophosphate to phosphate
YP_859900.1	membrane component of a  sugar ABC transporter system
YP_859901.1	catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate
YP_859904.1	protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD
YP_859906.1	activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions
YP_859907.1	Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates
YP_859909.1	phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel
YP_859910.1	regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon
YP_859911.1	P-type ATPase involved in magnesium influx
YP_859913.1	involved in the allosteric regulation of aspartate carbamoyltransferase
YP_859914.1	catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis
YP_859917.1	catalyzes the formation of ornithine and carbamylphosphate from citrulline in the arginine catabolic pathway
YP_859918.2	reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP
YP_859919.1	catalyzes the degradation of arginine to citruline and ammonia
YP_859925.1	valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain
YP_859926.1	binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB
YP_859927.1	catalyzes the removal of N-terminal amino acids preferably leucine from various peptides
YP_859933.1	Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate
YP_859934.1	NAD-binding
YP_859943.1	inversion of on/off regulator of fimA
YP_859944.1	inversion of on/off regulator of fimA
YP_859952.1	catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate
YP_859954.1	regulates the expression of uxuBA
YP_859955.1	inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS
YP_859957.1	with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone
YP_859958.1	with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase
YP_859959.1	forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone
YP_859966.1	catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate
YP_859967.1	Positively regulates the dhaKLM operon from a sigma-70 promoter
YP_859974.1	in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown
YP_859982.1	involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response
YP_859983.1	specificity determinant for hsdM and hsdR
YP_859985.1	restriction endonuclease; the EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'; subunit R is required for both nuclease and ATPase activities
YP_859996.1	catalyzes the transfer of phosphoglycerol to the glucan backbone
YP_859998.1	acts to load the DnaB helicase onto the initiation site during DNA replication
YP_859999.1	This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N'
YP_860002.1	global regulator
YP_860003.1	regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin
YP_860006.1	16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit
YP_860008.1	alanine acetyltransferase that specifically acetylates ribosomal protein S18
YP_860009.1	manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily
YP_860020.1	phage-related
YP_860021.1	phage-related
YP_860022.1	phage-related
YP_860023.1	phage-related
YP_860024.1	Holliday junction resolvase
YP_860033.1	phage-related
YP_860038.1	phage-related
YP_860047.1	phage-related
YP_860048.1	phage-related
YP_860050.1	phage-related
YP_860054.1	recombinase
YP_860056.1	stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein
YP_860062.1	catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate
YP_860063.1	Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate
YP_860064.1	catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose
YP_860065.1	catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate
YP_860067.1	Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins
YP_860069.2	catalyzes the formation of serine from O-phosphoserine
YP_860070.1	Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents
YP_860071.1	catalyzes the formation of NAD(+) from nicotinamide ribonucleotide
YP_860074.1	ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence
YP_860075.1	catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan
YP_860076.1	When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription
YP_860077.1	pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog
YP_860078.1	catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate
YP_860081.1	response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation
YP_860082.1	part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation
YP_860085.1	member of the SPOUT superfamily of methyltransferases
YP_001481156.1	IS1 InsA protein; similar to CAA11401
YP_001481157.1	IS1 InsB protein; identified by match to protein family HMM PF03400; similar to AAK09058
YP_001481158.2	stabilization of plasmid protein A; identified by match to protein family HMM PF01656; similar to NP_866033
YP_001481159.1	stabilization of plasmid protein B; identified by match to protein family HMM PF02195; match to protein family HMM TIGR00180; SopB
YP_001481161.1	transposase for IS186; similar to AAC75453; identified by match to protein family HMM PF01609
YP_001481162.1	putative antirestriction protein; similar to AAO49634; identified by match to protein family HMM PF03230
YP_001481163.1	similar to BAA84887
YP_001481164.1	similar to AAO49636
YP_001481165.1	similar to YP_053128
YP_001481166.1	putative hydrolase; similar to YP_194824
YP_001481167.1	similar to ZP00719055
YP_001481168.1	similar to AAO49639
YP_001481169.1	single-stranded binding protein; similar to AAO49641; identified by match to protein family HMM PF00436
YP_001481170.1	similar to AAR05684; identified by match to protein family HMM PF06006
YP_001481171.1	putative transcriptional regulator; similar to AAR05685
YP_001481172.1	plasmid SOS inhibition protein; similar to AAR25067; identified by match to protein family HMM PF06290
YP_001481173.1	plasmid SOS inhibition protein; similar to AAO49644; identified by match to protein family HMM PF06952; PsiA
YP_001481174.1	suppression of killing; similar to SOK_ECOLI
YP_001481175.1	modulator protein; similar to AAO49646; Mok; similar to F leading maintenance protein C
YP_001481177.1	similar to AAR05690
YP_001481178.1	similar to AAO49511
YP_001481179.1	similar to YP_190149; identified by match to protein family HMM PF06067
YP_001481180.1	similar to YP_190148; identified by match to protein family HMM PF01464
YP_001481181.1	conjugal transfer protein; similar to AAO49514; identified by match to protein family HMM PF05261
YP_001481182.1	positive regulator of conjugative transfer; similar to AAO49515
YP_001481183.1	conjugal transfer protein; similar to AAO49516; identified by match to protein family HMM PF05509
YP_001481184.1	pilin protein; similar to AAO49517; identified by match to protein family HMM PF05513
YP_001481185.1	conjugal transfer protein; similar to AAO49518; identified by match to protein family HMM PF07178
YP_001481186.1	conjugal transfer protein; similar to AAO49519; identified by match to protein family HMM PF05309
YP_001481187.1	conjugal transfer protein; similar to AAO49520; identified by match to protein family HMM PF06586
YP_001481188.1	conjugal transfer protein; similar to AAO49521; identified by match to protein family HMM PF06447
YP_001481189.1	conjugal transfer protein; similar to AAO49522; identified by match to protein family HMM PF07296
YP_001481190.1	conjugal transfer protein; similar to AAO49523
YP_001481191.1	conjugal transfer protein; similar to AAO49524
YP_001481192.1	conjugal transfer protein; similar to AAO49525
YP_001481193.1	conjugal transfer protein; similar to AAO49526
YP_001481194.1	pilus assembly and synthesis; similar to AAO49527; similar to VirB4
YP_001481195.1	conjugal transfer protein; similar to AAO49648
YP_001481196.2	conjugal transfer protein; similar to AAO49528
YP_001481197.1	conjugal transfer protein; similar to AAO49529; identified by match to protein family HMM PF06834
YP_001481198.1	periplasmic protein; similar to AAC44205
YP_001481199.1	mating pair stabilization protein; similar to AAO49531; identified by match to protein family HMM PF06986; TraN; TrhN; involved in stabilizing mating pairs during plasmid conjugation; F plasmid TraN appears to recognize OmpA in the recipient cell
YP_001481200.1	conjugal transfer protein; similar to AAO49532
YP_001481201.1	conjugal transfer protein; similar to AAO49533; type IV secretion system pilus assembly protein; similar to F plasmid TraF
YP_001481202.1	conjugal transfer protein; similar to AAO49534
YP_001481203.1	conserved hypothetical protein; similar to AAC44178
YP_001481204.1	pilin chaperone protein; similar to AAO49536
YP_001481205.1	conjugal transfer protein; similar to AAR25104
YP_001481206.1	conjugal transfer protein; similar to AAO49538
YP_001481207.1	conjugal transfer protein; similar to AAO49539
YP_001481208.1	pilus assembly protein; similar to YP_190118; identified by match to protein family HMM PF06122
YP_001481209.1	surface exclusion protein; similar to AAO49542
YP_001481210.1	surface exclusion and complement resistance protein; similar to AAT85681; identified by match to protein family HMM PF05818
YP_001481211.1	coupling protein; similar to AAC44181; type IV secretion system coupling protein; similar to F plasmid TraD
YP_001481212.1	conserved hypothetical protein; similar to AAP79033; identified by match to protein family HMM PF01850
YP_001481213.1	DNA helicase I; similar to YP_190115; identified by match to protein family HMM PF07057; cleaves origin of transfer and unwinds; oriT relaxase
YP_001481214.1	F pilin acetylase; similar to YP_190114
YP_001481215.1	putative hydrolase, alpha/beta fold family; similar to YP_190113; identified by match to protein family HMM PF00561
YP_001481216.1	fertility inhibition protein; similar to YP_313451; identified by match to protein family HMM PF05286
YP_001481217.1	similar to YP_313453
YP_001481218.1	modulator of post-segregational killing; similar to BAA97874
YP_001481219.1	replication regulatory protein; similar to BAA97876
YP_001481220.1	replication protein; similar to CAA23641
YP_001481221.1	repFIC initiation protein; similar to AAA99008
YP_001481222.2	replication protein; similar to AAO49555; identified by match to protein family HMM PF02387; IncFII replicon family; RepA
YP_001481223.1	replication protein; similar to NP_052991
YP_001481224.1	antitoxin of toxin stability system; similar to YP_313640; identified by match to protein family HMM PF02604
YP_001481225.1	cytotoxic translational repressor; similar to YP_313641; identified by match to protein family HMM PF05016
YP_001481226.1	transposase for IS629; similar to CAD88882; identified by match to protein family HMM PF00665
YP_001481227.1	similar to NP_288505
YP_001481228.1	temperature sensitive hemagglutinin; similar to AAA24698; identified by match to protein family HMM PF02395
YP_001481229.1	transposase fro IS1; similar to CAE55752
YP_001481230.1	IS1 InsB protein; similar to NP_863025; identified by match to protein family HMM PF03400
YP_001481231.1	similar to DQ269483; identified by match to protein family HMM PF01695
YP_001481232.1	similar to DQ269483; identified by match to protein family HMM PF00665
YP_001481233.1	similar to YP_194858
YP_001481234.1	similar to YP_194859
YP_001481235.1	virulence-associated gene D; similar to YP_194860; identified by match to protein family HMM PF01850
YP_001481236.1	putative acetyltransferase; similar to NP_761263; identified by match to protein family HMM PF04014
YP_001481237.1	putative dimethylaniline monoxygenase; similar to CAA11511; identified by match to protein family HMM PF00743
YP_001481238.1	similar to NP_875585
YP_001481239.1	putative oxidoreductase; similar to CAA11512; identified by match to protein family HMM PF01408
YP_001481240.1	putative hydrolase; similar to AAK03131; identified by match to protein family HMM TIGR01484
YP_001481241.1	putative aminotransferase; similar to NP_388936; identified by match to protein family HMM PF01041
YP_001481242.1	similar to NP_943348
YP_001481243.1	conserved hypothetical protein; similar to NP_943347
YP_001481244.1	similar to NP_943346
YP_001481246.1	similar to NP_755452; identified by match to protein family HMM PF01527
YP_001481247.1	putative transposase of ISEc8; identified by match to protein family HMM PF05717
YP_001481248.1	putative transposase; identified by match to protein family HMM PF03050
YP_001481249.1	similar to NP_085375; identified by match to protein family HMM PF01527
YP_001481250.1	IS2 transposase; similar to NP_418693; identified by match to protein family HMM PF00665; IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats
YP_001481251.1	putative adhesin; similar to BAB33785; identified by match to protein family HMM PF03212; match to protein family HMM PF03797
YP_001481252.1	similar to NP_288505
YP_001481253.1	IS629 transposase; similar to CAD88882; identified by match to protein family HMM PF00665
YP_001481254.1	putative iron transport system, membrane component; similar to ABA54770; identified by match to protein family HMM PF07690
YP_001481255.1	putative iron transport system, ATP-binding component; similar to AAX22060; identified by match to protein family HMM PF00005
YP_001481256.1	putative iron transport system, permease component; similar to AAX22061; identified by match to protein family HMM PF01032
YP_001481257.1	putative iron transport system, periplasmic binding protein; similar to AAX22062; identified by match to protein family HMM PF01497
YP_001481258.1	similar to EAN42275; identified by match to protein family HMM PF00239
YP_001481259.1	similar to AAC70078; identified by match to protein family HMM PF01402; ribbon-helix-helix protein, copG family domain
YP_001481260.1	similar to AAT94182; identified by match to protein family HMM PF05016; putative plasmid stabilization system protein
YP_001481261.1	similar to AAT94181
YP_001481262.1	IS1294 transposase; similar to AAM14707
YP_001481263.1	similar to ZP_00714559
YP_001481265.1	similar to AAP42487
YP_001481266.1	virulence-associated gene D; similar to AAP42488; identified by match to protein family HMM PF01850
YP_001481267.1	virulence associated gene C; similar to AAP42489; identified by match to protein family HMM PF04014
YP_001481269.1	similar to AAO49566
YP_001481270.1	similar to AAO49564
YP_001481271.1	putative site-specific recombinase; similar to YP_190186; identified by match to protein family HMM PF00589
YP_001481272.1	colicin M immunity protein; similar to IMMM_ECOLI
YP_001481273.1	colicin M activity protein; similar to CEAM_ECOLI
YP_001481274.1	colicin B immunity protein; similar to IMMB_ECOLI
YP_001481275.1	colicin B activity protein; similar to CEAB_ECOLI
YP_001481276.1	similar to AAT94181
YP_001481278.1	fusion between colicin V secretion protein and transposase for IS186; assembly verified for accuracy; amino acids 1-195 are similar to 1-195 of IS186 transposase, amino acids 198-523 are similar to 45-362 of cvaB; similar to identified by match to protein family HMM PF01609
YP_001481279.1	colicin V secretion protein; similar to CAA40743; identified by match to protein family HMM PF00529
YP_001481280.1	transposase for IS2; similar to NP_418693; identified by match to protein family HMM PF00665
YP_001481281.1	IS2 transposase subunit; similar to NP_839581; identified by match to protein family HMM PF01527; IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_001481282.1	similar to AAX22082
YP_001481283.1	unknown function; similar to AAZ05342
YP_001481284.1	plasmid stabilization system protein, RelE/ParE family superfamily; similar to YP_190105; identified by match to protein family HMM PF05016
YP_001481285.1	putative transposase; identified by match to protein family HMM PF00929
YP_001481286.1	putative cytoplasmic protein; similar to AAZ05345
YP_001481287.1	similar to YP_308785
YP_001481288.1	similar to AAX22086
YP_001481290.1	similar to CAC43413; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive
YP_001481291.1	similar to NP_753138
YP_001481292.1	similar to AAX22088
YP_001481293.1	salmochelin siderophore system, salmochelin receptor; similar to AAS80269; identified by match to protein family HMM PF00593; Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space
YP_001481294.1	salmochelin siderophore system component; similar to AAP42473
YP_001481295.1	salmochelin siderophore system, ferric enterochelin esterase; similar to AAS80267; identified by match to protein family HMM PF
YP_001481296.1	salmochelin siderophore system, ATP-binding cassette; similar to AAP41471; identified by match to protein family HMM PF00005
YP_001481297.1	salmochelin siderophore system, glycosyltransferase; similar to AAS80265; identified by match to protein family HMM PF06722
YP_001481298.1	similar to AAS80264
YP_001481299.1	putative integrase; similar to AAP42475; identified by match to protein family HMM PF00665
YP_001481300.1	similar to AAP42476
YP_001481301.1	similar to AAP41478
YP_001481302.1	increased serum survival protein; involved in complement resistance; similar to AAS80261; identified by match to protein family
YP_001481303.1	similar to AAX22091
YP_001481304.1	putative transposase; similar to NP_418692; identified by match to protein family HMM PF01527; IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats
YP_001481305.1	IS2 transposase; similar to AAO49621; identified by match to protein family HMM PF00665
YP_001481307.1	cobalamin synthesis protein cobW C-terminal domain; similar to AAX22904; identified by match to protein family HMM PF02492
YP_001481308.1	similar to AAX22096
YP_001481309.1	similar to AAX22097
YP_001481310.1	similar to AAX22097
YP_001481312.1	similar to YP_268363
YP_001481314.1	IS1 transposase; similar to AAO49620; identified by match to protein family HMM PF03400
YP_001481315.1	IS1 InsA protein; similar to AAO49621
YP_001481316.1	similar to AAO49625
YP_001481319.1	similar to AAO49623
YP_001481321.1	IS1 transposase; similar to AAO49620; identified by match to protein family HMM PF03400
YP_001481322.1	IS1 InsA protein; similar to AAO49621
YP_001481323.1	similar to ABA54745
YP_001481324.1	aerobactin siderophore system, ferric aerobactin receptor protein; similar to ABA54744; identified by match to protein family HMM PF00593
YP_001481325.1	aerobactin siderophore system, L-lysine 6-monooxygenase; similar to CAE55774
YP_001481326.1	aerobactin siderophore system, aerobactin biosynthesis protein; similar to ABA54742; identified by match to protein family HMMPFO4183
YP_001481327.1	aerobactin siderophore system, N-hydroxylysine acetylase; similar to ABA54741
YP_001481328.1	aerobactin siderophore system, aerobactin synthetase; similar to ABA54740; identified by match to protein family HMM PF04183
YP_001481329.1	transporter, major facilitator family subfamily; similar to AAZ29623; identified by match to protein family HMM PF07690
YP_001481330.1	similar to CAH64818; identified by match to protein family HMM PF02537; may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling
YP_001481331.1	similar to ABA54737
YP_001481332.1	putative enolase, C-terminal TIM barrel domain; similar to CAH64819; identified by match to protein family HMM PF00113
YP_001481333.1	ABC iron transport system, inner membrane component; similar to ABA54734; identified by match to protein family HMM PF00950
YP_001481334.1	ABC iron transport system, permease component; similar to AAT11266; identified by match to protein family HMM PF00950
YP_001481335.1	ABC iron transport system, ATP-binding component; similar to ABA54732; identified by match to protein family HMM PF00005
YP_001481336.1	ABC iron transport system, periplasmic binding protein; similar to AAT11264; identified by match to protein family HMM PF01297
YP_001481337.1	IS1 InsA protein; similar to AAO49621
YP_001481338.1	IS1 transposase; similar to AAO49620
YP_001481339.1	similar to AAO49619
YP_001481340.1	IS21 transposase; similar to AAO49618
YP_001481341.1	similar to AAR05705
YP_001481342.1	repFIB replication protein; similar to AAO49616; identified by match to protein family HMM PF01051
YP_001481343.1	site-specific integrase; similar to AAO49615; identified by match to protein family HMM PF00589
YP_001481344.1	putative transcriptional regulator; similar to AAO49614; identified by match to protein family HMM PF07395
YP_001481345.1	putative avian hemolysin; similar to AAO49613; identified by match to protein family HMM PF01073
YP_001481347.1	outer membrane protease; similar to ABA54754; identified by match to protein family HMM PF01278
YP_001481348.1	similar to ABA54756
YP_001481349.1	similar to NP_288505
YP_001481350.1	similar to CAD88882; identified by match to protein family HMM PF00665
YP_001481352.1	E. coli transport system, membrane fusion protein; similar to ABA54761; identified by match to protein family HMM PF00529
YP_001481353.1	E. coli transport system, ATP-binding/permease protein; similar to ABA54762; identified by match to protein family HMM PF00005
YP_001481354.1	E. coli transport system, efflux protein; similar to ABA54763; identified by match to protein family HMM PF02321
YP_001481355.1	putative replication protein
YP_001481356.1	putative pilin presursor
YP_001481357.1	putative plasmid transfer protein
YP_001481358.1	putative pilus assembly protein
YP_001481361.1	putative transport protein
YP_001481363.1	putative transfer-associated protein
YP_001481364.1	putative plasmid transfer protein
YP_001481365.1	putative pilus assembly protein
YP_001481366.1	putative plasmid partitioning protein
YP_001481367.1	putative plasmid partitioning protein
YP_001481372.1	plasmid partitioning protein
YP_001481373.1	plasmid partitioning protein
YP_001481375.1	IncHI2 transfer repressor
YP_001481376.1	putative exported plasmid transfer protein
YP_001481379.1	putative signal peptidase
YP_001481380.1	putative transfer protein
YP_001481381.1	putative transfer protein
YP_001481382.1	putative transfer protein; TraN; TrhN; involved in stabilizing mating pairs during plasmid conjugation; F plasmid TraN appears to recognize OmpA in the recipient cell
YP_001481384.1	putative DNA helicase
YP_001481410.1	tellurite resistance protein
YP_001481411.1	tellurite resistance protein
YP_001481412.1	tellurite resistance protein
YP_001481413.1	tellurite resistance protein
YP_001481414.1	tellurite resistance protein
YP_001481421.1	tellurite resistance protein
YP_001481422.1	tellurite resistance protein
YP_001481423.1	tellurite resistance protein
YP_001481424.1	tellurite resistance protein
YP_001481425.1	tellurite resistance protein
YP_001481426.1	tellurite resistance protein
YP_001481427.1	tellurite resistance protein
YP_001481436.1	tetracycline resistance protein
YP_001481437.1	tetracycline repressor protein
YP_001481441.1	integrase for class 1 integron
YP_001481442.2	streptomycin/spectinomycin resistance; adenlytransferase; streptomycin 3'-adenyltransferase
YP_001481443.1	gentamicin resistance protein
YP_001481444.1	chaperonin; heat shock protein; 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth
YP_001481448.2	sulfonamide resistance
YP_001481452.1	Tn7-like transposase
YP_001481453.1	Tn7-like transposase
YP_001481454.1	Tn7-like transposase
YP_001481455.1	Tn7-like transposase
YP_001481462.1	silver binding protein; silver resistance
YP_001481463.1	putative sensor kinase; silver resistance
YP_001481464.1	putative transcriptional regulatory protein; silver resistance; response regulator in two-component regulatory system with CusS; regulates the copper efflux system
YP_001481465.1	outer membrane efflux protein; silver resistance; with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver
YP_001481467.1	silver resistance protein; with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver
YP_001481468.1	cation efflux system protein; silver resistance
YP_001481470.1	cation-transporting P-type ATPase; silver resistance
YP_001481472.1	copper resistance protein
YP_001481473.1	copper resistance protein
YP_001481474.1	copper resistance protein
YP_001481475.1	copper resistance protein
YP_001481476.1	copper resistance protein
YP_001481477.1	copper resistance regulatory protein
YP_001481478.1	copper resistance sensor kinase
YP_001481479.1	copper binding protein
YP_001481497.1	thiol:disulfide interchange protein
YP_001481508.1	plasmid transfer protein
YP_001481509.1	plasmid transfer protein
YP_001481511.1	plasmid transfer protein
YP_001481529.1	plasmid stable inheritance protein