-- dump date 20140619_081200 -- class Genbank::misc_feature -- table misc_feature_note -- id note 405955000001 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 405955000002 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 405955000003 putative catalytic residues [active] 405955000004 putative nucleotide binding site [chemical binding]; other site 405955000005 putative aspartate binding site [chemical binding]; other site 405955000006 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 405955000007 dimer interface [polypeptide binding]; other site 405955000008 putative threonine allosteric regulatory site; other site 405955000009 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 405955000010 putative threonine allosteric regulatory site; other site 405955000011 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 405955000012 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 405955000013 homoserine kinase; Region: thrB; TIGR00191 405955000014 Protein of unknown function; Region: YhfT; pfam10797 405955000015 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 405955000016 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 405955000017 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 405955000018 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955000019 catalytic residue [active] 405955000020 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 405955000021 hypothetical protein; Validated; Region: PRK02101 405955000022 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 405955000023 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 405955000024 transaldolase-like protein; Provisional; Region: PTZ00411 405955000025 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 405955000026 active site 405955000027 dimer interface [polypeptide binding]; other site 405955000028 catalytic residue [active] 405955000029 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 405955000030 MPT binding site; other site 405955000031 trimer interface [polypeptide binding]; other site 405955000032 hypothetical protein; Provisional; Region: PRK10659 405955000033 hypothetical protein; Provisional; Region: PRK10236 405955000034 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 405955000035 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 405955000036 hypothetical protein; Provisional; Region: PRK10154 405955000037 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 405955000038 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 405955000039 nucleotide binding site [chemical binding]; other site 405955000040 NEF interaction site [polypeptide binding]; other site 405955000041 SBD interface [polypeptide binding]; other site 405955000042 chaperone protein DnaJ; Provisional; Region: PRK10767 405955000043 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 405955000044 HSP70 interaction site [polypeptide binding]; other site 405955000045 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 405955000046 substrate binding site [polypeptide binding]; other site 405955000047 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 405955000048 Zn binding sites [ion binding]; other site 405955000049 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 405955000050 dimer interface [polypeptide binding]; other site 405955000051 Nucleoside-specific channel-forming protein, Tsx; Region: Channel_Tsx; pfam03502 405955000052 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 405955000053 Sulfatase; Region: Sulfatase; pfam00884 405955000054 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 405955000055 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 405955000056 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955000057 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 405955000058 putative dimerization interface [polypeptide binding]; other site 405955000059 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 405955000060 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 405955000061 active site 405955000062 Riboflavin kinase; Region: Flavokinase; smart00904 405955000063 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 405955000064 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405955000065 HIGH motif; other site 405955000066 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 405955000067 active site 405955000068 KMSKS motif; other site 405955000069 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 405955000070 tRNA binding surface [nucleotide binding]; other site 405955000071 anticodon binding site; other site 405955000072 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 405955000073 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 405955000074 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 405955000075 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 405955000076 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 405955000077 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 405955000078 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 405955000079 active site 405955000080 tetramer interface [polypeptide binding]; other site 405955000081 Protein of unknown function (DUF805); Region: DUF805; pfam05656 405955000082 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 405955000083 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 405955000084 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 405955000085 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 405955000086 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 405955000087 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 405955000088 catalytic site [active] 405955000089 subunit interface [polypeptide binding]; other site 405955000090 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 405955000091 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405955000092 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405955000093 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 405955000094 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405955000095 ATP-grasp domain; Region: ATP-grasp_4; cl17255 405955000096 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 405955000097 IMP binding site; other site 405955000098 dimer interface [polypeptide binding]; other site 405955000099 interdomain contacts; other site 405955000100 partial ornithine binding site; other site 405955000101 Transposase IS200 like; Region: Y1_Tnp; pfam01797 405955000102 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 405955000103 carnitine operon protein CaiE; Provisional; Region: PRK13627 405955000104 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 405955000105 putative trimer interface [polypeptide binding]; other site 405955000106 putative metal binding site [ion binding]; other site 405955000107 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 405955000108 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405955000109 substrate binding site [chemical binding]; other site 405955000110 oxyanion hole (OAH) forming residues; other site 405955000111 trimer interface [polypeptide binding]; other site 405955000112 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 405955000113 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 405955000114 acyl-activating enzyme (AAE) consensus motif; other site 405955000115 putative AMP binding site [chemical binding]; other site 405955000116 putative active site [active] 405955000117 putative CoA binding site [chemical binding]; other site 405955000118 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 405955000119 CoA-transferase family III; Region: CoA_transf_3; pfam02515 405955000120 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 405955000121 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 405955000122 active site 405955000123 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 405955000124 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 405955000125 Ligand binding site [chemical binding]; other site 405955000126 Electron transfer flavoprotein domain; Region: ETF; pfam01012 405955000127 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 405955000128 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 405955000129 Ligand binding site [chemical binding]; other site 405955000130 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 405955000131 putative oxidoreductase FixC; Provisional; Region: PRK10157 405955000132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955000133 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 405955000134 putative substrate translocation pore; other site 405955000135 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 405955000136 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 405955000137 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 405955000138 TrkA-N domain; Region: TrkA_N; pfam02254 405955000139 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 405955000140 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 405955000141 folate binding site [chemical binding]; other site 405955000142 NADP+ binding site [chemical binding]; other site 405955000143 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 405955000144 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 405955000145 active site 405955000146 metal binding site [ion binding]; metal-binding site 405955000147 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 405955000148 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 405955000149 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 405955000150 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 405955000151 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 405955000152 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 405955000153 SurA N-terminal domain; Region: SurA_N; pfam09312 405955000154 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405955000155 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 405955000156 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 405955000157 OstA-like protein; Region: OstA; pfam03968 405955000158 Organic solvent tolerance protein; Region: OstA_C; pfam04453 405955000159 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 405955000160 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 405955000161 putative metal binding site [ion binding]; other site 405955000162 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 405955000163 HSP70 interaction site [polypeptide binding]; other site 405955000164 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 405955000165 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405955000166 active site 405955000167 ATP-dependent helicase HepA; Validated; Region: PRK04914 405955000168 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405955000169 ATP binding site [chemical binding]; other site 405955000170 putative Mg++ binding site [ion binding]; other site 405955000171 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405955000172 nucleotide binding region [chemical binding]; other site 405955000173 ATP-binding site [chemical binding]; other site 405955000174 DNA polymerase II; Reviewed; Region: PRK05762 405955000175 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 405955000176 active site 405955000177 catalytic site [active] 405955000178 substrate binding site [chemical binding]; other site 405955000179 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 405955000180 active site 405955000181 metal-binding site 405955000182 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 405955000183 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 405955000184 intersubunit interface [polypeptide binding]; other site 405955000185 active site 405955000186 Zn2+ binding site [ion binding]; other site 405955000187 L-arabinose isomerase; Provisional; Region: PRK02929 405955000188 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 405955000189 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 405955000190 trimer interface [polypeptide binding]; other site 405955000191 putative substrate binding site [chemical binding]; other site 405955000192 putative metal binding site [ion binding]; other site 405955000193 ribulokinase; Provisional; Region: PRK04123 405955000194 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 405955000195 N- and C-terminal domain interface [polypeptide binding]; other site 405955000196 active site 405955000197 MgATP binding site [chemical binding]; other site 405955000198 catalytic site [active] 405955000199 metal binding site [ion binding]; metal-binding site 405955000200 carbohydrate binding site [chemical binding]; other site 405955000201 homodimer interface [polypeptide binding]; other site 405955000202 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 405955000203 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 405955000204 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955000205 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955000206 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405955000207 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405955000208 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 405955000209 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 405955000210 Walker A/P-loop; other site 405955000211 ATP binding site [chemical binding]; other site 405955000212 Q-loop/lid; other site 405955000213 ABC transporter signature motif; other site 405955000214 Walker B; other site 405955000215 D-loop; other site 405955000216 H-loop/switch region; other site 405955000217 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 405955000218 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955000219 dimer interface [polypeptide binding]; other site 405955000220 conserved gate region; other site 405955000221 putative PBP binding loops; other site 405955000222 ABC-ATPase subunit interface; other site 405955000223 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955000224 dimer interface [polypeptide binding]; other site 405955000225 conserved gate region; other site 405955000226 putative PBP binding loops; other site 405955000227 ABC-ATPase subunit interface; other site 405955000228 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 405955000229 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 405955000230 transcriptional regulator SgrR; Provisional; Region: PRK13626 405955000231 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 405955000232 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 405955000233 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 405955000234 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 405955000235 substrate binding site [chemical binding]; other site 405955000236 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 405955000237 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 405955000238 substrate binding site [chemical binding]; other site 405955000239 ligand binding site [chemical binding]; other site 405955000240 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 405955000241 tartrate dehydrogenase; Region: TTC; TIGR02089 405955000242 2-isopropylmalate synthase; Validated; Region: PRK00915 405955000243 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 405955000244 active site 405955000245 catalytic residues [active] 405955000246 metal binding site [ion binding]; metal-binding site 405955000247 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 405955000248 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 405955000249 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955000250 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 405955000251 putative substrate binding pocket [chemical binding]; other site 405955000252 putative dimerization interface [polypeptide binding]; other site 405955000253 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cl02915 405955000254 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 405955000255 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405955000256 PYR/PP interface [polypeptide binding]; other site 405955000257 dimer interface [polypeptide binding]; other site 405955000258 TPP binding site [chemical binding]; other site 405955000259 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405955000260 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 405955000261 TPP-binding site [chemical binding]; other site 405955000262 dimer interface [polypeptide binding]; other site 405955000263 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 405955000264 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 405955000265 putative valine binding site [chemical binding]; other site 405955000266 dimer interface [polypeptide binding]; other site 405955000267 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 405955000268 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 405955000269 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955000270 DNA binding site [nucleotide binding] 405955000271 domain linker motif; other site 405955000272 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 405955000273 dimerization interface [polypeptide binding]; other site 405955000274 ligand binding site [chemical binding]; other site 405955000275 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 405955000276 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 405955000277 cell division protein FtsL; Provisional; Region: PRK10772 405955000278 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 405955000279 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405955000280 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405955000281 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 405955000282 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405955000283 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405955000284 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405955000285 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 405955000286 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405955000287 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405955000288 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405955000289 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 405955000290 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 405955000291 Mg++ binding site [ion binding]; other site 405955000292 putative catalytic motif [active] 405955000293 putative substrate binding site [chemical binding]; other site 405955000294 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 405955000295 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405955000296 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405955000297 cell division protein FtsW; Provisional; Region: PRK10774 405955000298 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 405955000299 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 405955000300 active site 405955000301 homodimer interface [polypeptide binding]; other site 405955000302 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 405955000303 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405955000304 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405955000305 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405955000306 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 405955000307 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 405955000308 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 405955000309 cell division protein FtsQ; Provisional; Region: PRK10775 405955000310 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 405955000311 Cell division protein FtsQ; Region: FtsQ; pfam03799 405955000312 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 405955000313 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405955000314 Cell division protein FtsA; Region: FtsA; pfam14450 405955000315 cell division protein FtsZ; Validated; Region: PRK09330 405955000316 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 405955000317 nucleotide binding site [chemical binding]; other site 405955000318 SulA interaction site; other site 405955000319 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 405955000320 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 405955000321 SecA regulator SecM; Provisional; Region: PRK02943 405955000322 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 405955000323 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 405955000324 SEC-C motif; Region: SEC-C; pfam02810 405955000325 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 405955000326 active site 405955000327 8-oxo-dGMP binding site [chemical binding]; other site 405955000328 nudix motif; other site 405955000329 metal binding site [ion binding]; metal-binding site 405955000330 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 405955000331 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 405955000332 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 405955000333 CoA-binding site [chemical binding]; other site 405955000334 ATP-binding [chemical binding]; other site 405955000335 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 405955000336 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 405955000337 active site 405955000338 type IV pilin biogenesis protein; Provisional; Region: PRK10573 405955000339 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 405955000340 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 405955000341 hypothetical protein; Provisional; Region: PRK10436 405955000342 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 405955000343 Walker A motif; other site 405955000344 ATP binding site [chemical binding]; other site 405955000345 Walker B motif; other site 405955000346 putative major pilin subunit; Provisional; Region: PRK10574 405955000347 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 405955000348 Pilin (bacterial filament); Region: Pilin; pfam00114 405955000349 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 405955000350 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 405955000351 dimerization interface [polypeptide binding]; other site 405955000352 active site 405955000353 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 405955000354 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405955000355 amidase catalytic site [active] 405955000356 Zn binding residues [ion binding]; other site 405955000357 substrate binding site [chemical binding]; other site 405955000358 regulatory protein AmpE; Provisional; Region: PRK10987 405955000359 aromatic amino acid transporter; Provisional; Region: PRK10238 405955000360 Protein of unknown function (DUF796); Region: DUF796; cl01226 405955000361 S-type Pyocin; Region: Pyocin_S; pfam06958 405955000362 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405955000363 active site 405955000364 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 405955000365 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 405955000366 Colicin immunity protein / pyocin immunity protein; Region: Colicin_Pyocin; pfam01320 405955000367 Transcriptional regulators [Transcription]; Region: FadR; COG2186 405955000368 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955000369 DNA-binding site [nucleotide binding]; DNA binding site 405955000370 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 405955000371 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 405955000372 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 405955000373 dimer interface [polypeptide binding]; other site 405955000374 TPP-binding site [chemical binding]; other site 405955000375 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 405955000376 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405955000377 E3 interaction surface; other site 405955000378 lipoyl attachment site [posttranslational modification]; other site 405955000379 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405955000380 E3 interaction surface; other site 405955000381 lipoyl attachment site [posttranslational modification]; other site 405955000382 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405955000383 E3 interaction surface; other site 405955000384 lipoyl attachment site [posttranslational modification]; other site 405955000385 e3 binding domain; Region: E3_binding; pfam02817 405955000386 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405955000387 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 405955000388 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405955000389 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955000390 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405955000391 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 405955000392 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 405955000393 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 405955000394 substrate binding site [chemical binding]; other site 405955000395 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 405955000396 substrate binding site [chemical binding]; other site 405955000397 ligand binding site [chemical binding]; other site 405955000398 Uncharacterized protein family (UPF0231); Region: UPF0231; cl11474 405955000399 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 405955000400 spermidine synthase; Provisional; Region: PRK00811 405955000401 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955000402 S-adenosylmethionine binding site [chemical binding]; other site 405955000403 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 405955000404 multicopper oxidase; Provisional; Region: PRK10965 405955000405 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 405955000406 Multicopper oxidase; Region: Cu-oxidase; pfam00394 405955000407 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 405955000408 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 405955000409 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 405955000410 Trp docking motif [polypeptide binding]; other site 405955000411 putative active site [active] 405955000412 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405955000413 active site 405955000414 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 405955000415 active site clefts [active] 405955000416 zinc binding site [ion binding]; other site 405955000417 dimer interface [polypeptide binding]; other site 405955000418 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405955000419 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405955000420 Walker A/P-loop; other site 405955000421 ATP binding site [chemical binding]; other site 405955000422 Q-loop/lid; other site 405955000423 ABC transporter signature motif; other site 405955000424 Walker B; other site 405955000425 D-loop; other site 405955000426 H-loop/switch region; other site 405955000427 inner membrane transport permease; Provisional; Region: PRK15066 405955000428 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 405955000429 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 405955000430 active pocket/dimerization site; other site 405955000431 active site 405955000432 phosphorylation site [posttranslational modification] 405955000433 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 405955000434 putative active site [active] 405955000435 putative metal binding site [ion binding]; other site 405955000436 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 405955000437 tetramerization interface [polypeptide binding]; other site 405955000438 active site 405955000439 Uncharacterized conserved protein [Function unknown]; Region: COG5464 405955000440 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 405955000441 pantoate--beta-alanine ligase; Region: panC; TIGR00018 405955000442 Pantoate-beta-alanine ligase; Region: PanC; cd00560 405955000443 active site 405955000444 ATP-binding site [chemical binding]; other site 405955000445 pantoate-binding site; other site 405955000446 HXXH motif; other site 405955000447 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 405955000448 oligomerization interface [polypeptide binding]; other site 405955000449 active site 405955000450 metal binding site [ion binding]; metal-binding site 405955000451 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 405955000452 putative fimbrial protein StaF; Provisional; Region: PRK15262 405955000453 putative fimbrial protein StaE; Provisional; Region: PRK15263 405955000454 Fimbrial protein; Region: Fimbrial; cl01416 405955000455 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 405955000456 PapC N-terminal domain; Region: PapC_N; pfam13954 405955000457 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 405955000458 PapC C-terminal domain; Region: PapC_C; pfam13953 405955000459 putative chaperone protein EcpD; Provisional; Region: PRK09926 405955000460 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 405955000461 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 405955000462 Fimbrial protein; Region: Fimbrial; cl01416 405955000463 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 405955000464 catalytic center binding site [active] 405955000465 ATP binding site [chemical binding]; other site 405955000466 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 405955000467 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 405955000468 active site 405955000469 NTP binding site [chemical binding]; other site 405955000470 metal binding triad [ion binding]; metal-binding site 405955000471 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 405955000472 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 405955000473 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 405955000474 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 405955000475 active site 405955000476 nucleotide binding site [chemical binding]; other site 405955000477 HIGH motif; other site 405955000478 KMSKS motif; other site 405955000479 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 405955000480 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 405955000481 2'-5' RNA ligase; Provisional; Region: PRK15124 405955000482 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 405955000483 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 405955000484 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 405955000485 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405955000486 ATP binding site [chemical binding]; other site 405955000487 putative Mg++ binding site [ion binding]; other site 405955000488 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405955000489 nucleotide binding region [chemical binding]; other site 405955000490 ATP-binding site [chemical binding]; other site 405955000491 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 405955000492 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 405955000493 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 405955000494 Transglycosylase; Region: Transgly; pfam00912 405955000495 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 405955000496 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 405955000497 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 405955000498 N-terminal plug; other site 405955000499 ligand-binding site [chemical binding]; other site 405955000500 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 405955000501 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405955000502 Walker A/P-loop; other site 405955000503 ATP binding site [chemical binding]; other site 405955000504 Q-loop/lid; other site 405955000505 ABC transporter signature motif; other site 405955000506 Walker B; other site 405955000507 D-loop; other site 405955000508 H-loop/switch region; other site 405955000509 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 405955000510 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 405955000511 siderophore binding site; other site 405955000512 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405955000513 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955000514 ABC-ATPase subunit interface; other site 405955000515 dimer interface [polypeptide binding]; other site 405955000516 putative PBP binding regions; other site 405955000517 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955000518 ABC-ATPase subunit interface; other site 405955000519 dimer interface [polypeptide binding]; other site 405955000520 putative PBP binding regions; other site 405955000521 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 405955000522 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405955000523 inhibitor-cofactor binding pocket; inhibition site 405955000524 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955000525 catalytic residue [active] 405955000526 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 405955000527 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 405955000528 Cl- selectivity filter; other site 405955000529 Cl- binding residues [ion binding]; other site 405955000530 pore gating glutamate residue; other site 405955000531 dimer interface [polypeptide binding]; other site 405955000532 H+/Cl- coupling transport residue; other site 405955000533 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 405955000534 hypothetical protein; Provisional; Region: PRK10578 405955000535 UPF0126 domain; Region: UPF0126; pfam03458 405955000536 UPF0126 domain; Region: UPF0126; pfam03458 405955000537 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 405955000538 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 405955000539 cobalamin binding residues [chemical binding]; other site 405955000540 putative BtuC binding residues; other site 405955000541 dimer interface [polypeptide binding]; other site 405955000542 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 405955000543 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 405955000544 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 405955000545 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405955000546 Zn2+ binding site [ion binding]; other site 405955000547 Mg2+ binding site [ion binding]; other site 405955000548 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 405955000549 serine endoprotease; Provisional; Region: PRK10942 405955000550 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 405955000551 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405955000552 protein binding site [polypeptide binding]; other site 405955000553 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405955000554 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 405955000555 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 405955000556 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 405955000557 hypothetical protein; Provisional; Region: PRK13677 405955000558 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 405955000559 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 405955000560 trimer interface [polypeptide binding]; other site 405955000561 active site 405955000562 substrate binding site [chemical binding]; other site 405955000563 CoA binding site [chemical binding]; other site 405955000564 PII uridylyl-transferase; Provisional; Region: PRK05007 405955000565 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 405955000566 metal binding triad; other site 405955000567 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 405955000568 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405955000569 Zn2+ binding site [ion binding]; other site 405955000570 Mg2+ binding site [ion binding]; other site 405955000571 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 405955000572 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 405955000573 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 405955000574 active site 405955000575 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 405955000576 rRNA interaction site [nucleotide binding]; other site 405955000577 S8 interaction site; other site 405955000578 putative laminin-1 binding site; other site 405955000579 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 405955000580 putative nucleotide binding site [chemical binding]; other site 405955000581 uridine monophosphate binding site [chemical binding]; other site 405955000582 homohexameric interface [polypeptide binding]; other site 405955000583 ribosome recycling factor; Reviewed; Region: frr; PRK00083 405955000584 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 405955000585 hinge region; other site 405955000586 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 405955000587 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 405955000588 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 405955000589 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 405955000590 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 405955000591 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 405955000592 catalytic residue [active] 405955000593 putative FPP diphosphate binding site; other site 405955000594 putative FPP binding hydrophobic cleft; other site 405955000595 dimer interface [polypeptide binding]; other site 405955000596 putative IPP diphosphate binding site; other site 405955000597 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 405955000598 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 405955000599 zinc metallopeptidase RseP; Provisional; Region: PRK10779 405955000600 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 405955000601 active site 405955000602 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 405955000603 protein binding site [polypeptide binding]; other site 405955000604 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 405955000605 putative substrate binding region [chemical binding]; other site 405955000606 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 405955000607 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 405955000608 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 405955000609 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 405955000610 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 405955000611 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 405955000612 Surface antigen; Region: Bac_surface_Ag; pfam01103 405955000613 periplasmic chaperone; Provisional; Region: PRK10780 405955000614 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 405955000615 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 405955000616 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 405955000617 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 405955000618 trimer interface [polypeptide binding]; other site 405955000619 active site 405955000620 UDP-GlcNAc binding site [chemical binding]; other site 405955000621 lipid binding site [chemical binding]; lipid-binding site 405955000622 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 405955000623 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 405955000624 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 405955000625 active site 405955000626 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 405955000627 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 405955000628 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 405955000629 RNA/DNA hybrid binding site [nucleotide binding]; other site 405955000630 active site 405955000631 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 405955000632 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 405955000633 putative active site [active] 405955000634 putative PHP Thumb interface [polypeptide binding]; other site 405955000635 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 405955000636 generic binding surface II; other site 405955000637 generic binding surface I; other site 405955000638 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 405955000639 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 405955000640 lysine decarboxylase LdcC; Provisional; Region: PRK15399 405955000641 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 405955000642 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 405955000643 homodimer interface [polypeptide binding]; other site 405955000644 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955000645 catalytic residue [active] 405955000646 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405955000647 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 405955000648 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405955000649 putative metal binding site [ion binding]; other site 405955000650 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 405955000651 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 405955000652 Ligand Binding Site [chemical binding]; other site 405955000653 TilS substrate binding domain; Region: TilS; pfam09179 405955000654 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 405955000655 Rho-binding antiterminator; Provisional; Region: PRK11625 405955000656 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 405955000657 hypothetical protein; Provisional; Region: PRK09256 405955000658 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 405955000659 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 405955000660 NlpE N-terminal domain; Region: NlpE; pfam04170 405955000661 hypothetical protein; Provisional; Region: PRK11479 405955000662 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 405955000663 prolyl-tRNA synthetase; Provisional; Region: PRK09194 405955000664 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 405955000665 dimer interface [polypeptide binding]; other site 405955000666 motif 1; other site 405955000667 active site 405955000668 motif 2; other site 405955000669 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 405955000670 putative deacylase active site [active] 405955000671 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 405955000672 active site 405955000673 motif 3; other site 405955000674 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 405955000675 anticodon binding site; other site 405955000676 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 405955000677 homodimer interaction site [polypeptide binding]; other site 405955000678 cofactor binding site; other site 405955000679 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 405955000680 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 405955000681 lipoprotein, YaeC family; Region: TIGR00363 405955000682 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955000683 dimer interface [polypeptide binding]; other site 405955000684 conserved gate region; other site 405955000685 ABC-ATPase subunit interface; other site 405955000686 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 405955000687 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 405955000688 Walker A/P-loop; other site 405955000689 ATP binding site [chemical binding]; other site 405955000690 Q-loop/lid; other site 405955000691 ABC transporter signature motif; other site 405955000692 Walker B; other site 405955000693 D-loop; other site 405955000694 H-loop/switch region; other site 405955000695 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 405955000696 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 405955000697 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955000698 active site 405955000699 motif I; other site 405955000700 motif II; other site 405955000701 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405955000702 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405955000703 active site 405955000704 catalytic tetrad [active] 405955000705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405955000706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955000707 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 405955000708 putative effector binding pocket; other site 405955000709 dimerization interface [polypeptide binding]; other site 405955000710 hypothetical protein; Provisional; Region: PRK05421 405955000711 putative catalytic site [active] 405955000712 putative metal binding site [ion binding]; other site 405955000713 putative phosphate binding site [ion binding]; other site 405955000714 putative catalytic site [active] 405955000715 putative phosphate binding site [ion binding]; other site 405955000716 putative metal binding site [ion binding]; other site 405955000717 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405955000718 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955000719 S-adenosylmethionine binding site [chemical binding]; other site 405955000720 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 405955000721 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405955000722 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405955000723 catalytic residue [active] 405955000724 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405955000725 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405955000726 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 405955000727 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955000728 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 405955000729 RNA/DNA hybrid binding site [nucleotide binding]; other site 405955000730 active site 405955000731 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 405955000732 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 405955000733 active site 405955000734 catalytic site [active] 405955000735 substrate binding site [chemical binding]; other site 405955000736 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 405955000737 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 405955000738 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 405955000739 ImpA domain protein; Region: DUF3702; pfam12486 405955000740 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 405955000741 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 405955000742 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 405955000743 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 405955000744 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 405955000745 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 405955000746 type VI secretion-associated protein, VC_A0118 family; Region: VI_minor_1; TIGR03360 405955000747 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 405955000748 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955000749 Walker A motif; other site 405955000750 ATP binding site [chemical binding]; other site 405955000751 Walker B motif; other site 405955000752 arginine finger; other site 405955000753 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955000754 Walker A motif; other site 405955000755 ATP binding site [chemical binding]; other site 405955000756 Walker B motif; other site 405955000757 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405955000758 Type VI protein secretion system component VasF [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3455 405955000759 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3522 405955000760 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 405955000761 type VI secretion lipoprotein, VC_A0113 family; Region: VI_chp_3; TIGR03352 405955000762 type VI secretion system FHA domain protein; Region: VI_FHA; TIGR03354 405955000763 FHA domain; Region: FHA; pfam00498 405955000764 type VI secretion protein, VC_A0111 family; Region: VI_chp_1; TIGR03347 405955000765 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 405955000766 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 405955000767 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 405955000768 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517 405955000769 Protein of unknown function (DUF877); Region: DUF877; pfam05943 405955000770 Protein of unknown function (DUF770); Region: DUF770; pfam05591 405955000771 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 405955000772 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 405955000773 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 405955000774 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 405955000775 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 405955000776 Gp5 C-terminal repeat (3 copies); Region: Gp5_C; pfam06715 405955000777 Uncharacterized protein conserved in bacteria (DUF2169); Region: DUF2169; pfam09937 405955000778 Domain of unknown function (DUF4150); Region: DUF4150; pfam13665 405955000779 Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various bacteriocins (mostly non-lantibiotic); Region: Peptidase_C39_like; cd02259 405955000780 putative active site [active] 405955000781 Transposase [DNA replication, recombination, and repair]; Region: COG5433 405955000782 Protein of unknown function (DUF2859); Region: DUF2859; pfam11072 405955000783 C-N hydrolase family amidase; Provisional; Region: PRK10438 405955000784 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 405955000785 putative active site [active] 405955000786 catalytic triad [active] 405955000787 dimer interface [polypeptide binding]; other site 405955000788 multimer interface [polypeptide binding]; other site 405955000789 C-lysozyme inhibitor; Provisional; Region: PRK09993 405955000790 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 405955000791 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 405955000792 active site 405955000793 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 405955000794 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 405955000795 dimer interface [polypeptide binding]; other site 405955000796 active site 405955000797 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 405955000798 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 405955000799 putative active site [active] 405955000800 putative dimer interface [polypeptide binding]; other site 405955000801 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 405955000802 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405955000803 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405955000804 NlpC/P60 family; Region: NLPC_P60; pfam00877 405955000805 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 405955000806 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 405955000807 FHIPEP family; Region: FHIPEP; pfam00771 405955000808 hypothetical protein; Validated; Region: PRK06778 405955000809 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405955000810 ligand binding site [chemical binding]; other site 405955000811 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 405955000812 active site 405955000813 DNA polymerase IV; Validated; Region: PRK02406 405955000814 DNA binding site [nucleotide binding] 405955000815 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 405955000816 putative toxin YafO; Provisional; Region: PRK09885 405955000817 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405955000818 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405955000819 Coenzyme A binding pocket [chemical binding]; other site 405955000820 hypothetical protein; Reviewed; Region: PRK09588 405955000821 release factor H-coupled RctB family protein; Region: release_rtcB; TIGR03073 405955000822 peptide chain release factor-like protein; Reviewed; Region: prfH; PRK08179 405955000823 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 405955000824 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 405955000825 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 405955000826 metal binding site [ion binding]; metal-binding site 405955000827 dimer interface [polypeptide binding]; other site 405955000828 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405955000829 active site 405955000830 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 405955000831 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 405955000832 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 405955000833 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 405955000834 trimer interface [polypeptide binding]; other site 405955000835 eyelet of channel; other site 405955000836 gamma-glutamyl kinase; Provisional; Region: PRK05429 405955000837 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 405955000838 nucleotide binding site [chemical binding]; other site 405955000839 homotetrameric interface [polypeptide binding]; other site 405955000840 putative phosphate binding site [ion binding]; other site 405955000841 putative allosteric binding site; other site 405955000842 PUA domain; Region: PUA; pfam01472 405955000843 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 405955000844 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 405955000845 putative catalytic cysteine [active] 405955000846 Helix-turn-helix domain; Region: HTH_36; pfam13730 405955000847 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 405955000848 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405955000849 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 405955000850 active site 405955000851 DNA binding site [nucleotide binding] 405955000852 Int/Topo IB signature motif; other site 405955000853 MarR family; Region: MarR_2; cl17246 405955000854 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405955000855 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 405955000856 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 405955000857 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 405955000858 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 405955000859 Autotransporter beta-domain; Region: Autotransporter; pfam03797 405955000860 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 405955000861 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 405955000862 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 405955000863 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 405955000864 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405955000865 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955000866 DNA binding residues [nucleotide binding] 405955000867 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 405955000868 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 405955000869 Old yellow enzyme (OYE)-related FMN binding domain, group 4. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a reducing agent with oxygens, quinones, and alpha,beta-unsaturated aldehydes and ketones, and can act as...; Region: OYE_like_4_FMN; cd04735 405955000870 putative active site [active] 405955000871 putative FMN binding site [chemical binding]; other site 405955000872 putative substrate binding site [chemical binding]; other site 405955000873 putative catalytic residue [active] 405955000874 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 405955000875 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405955000876 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955000877 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 405955000878 putative effector binding pocket; other site 405955000879 putative dimerization interface [polypeptide binding]; other site 405955000880 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405955000881 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955000882 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 405955000883 putative effector binding pocket; other site 405955000884 putative dimerization interface [polypeptide binding]; other site 405955000885 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405955000886 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405955000887 active site 405955000888 catalytic tetrad [active] 405955000889 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405955000890 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405955000891 active site 405955000892 catalytic tetrad [active] 405955000893 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 405955000894 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 405955000895 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 405955000896 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 405955000897 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 405955000898 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 405955000899 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955000900 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 405955000901 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405955000902 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405955000903 active site 405955000904 catalytic tetrad [active] 405955000905 Predicted membrane protein [Function unknown]; Region: COG3059 405955000906 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 405955000907 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 405955000908 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955000909 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405955000910 Cupin; Region: Cupin_6; pfam12852 405955000911 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 405955000912 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955000913 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 405955000914 Cysteine-rich domain; Region: CCG; pfam02754 405955000915 Cysteine-rich domain; Region: CCG; pfam02754 405955000916 iron-sulfur cluster-binding protein; Region: TIGR00273 405955000917 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 405955000918 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405955000919 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 405955000920 Uncharacterized conserved protein [Function unknown]; Region: COG1556 405955000921 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 405955000922 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 405955000923 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 405955000924 Autotransporter beta-domain; Region: Autotransporter; pfam03797 405955000925 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405955000926 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955000927 DNA binding residues [nucleotide binding] 405955000928 dimerization interface [polypeptide binding]; other site 405955000929 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405955000930 active site 405955000931 DNA binding site [nucleotide binding] 405955000932 Int/Topo IB signature motif; other site 405955000933 choline dehydrogenase; Validated; Region: PRK02106 405955000934 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 405955000935 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 405955000936 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 405955000937 tetrameric interface [polypeptide binding]; other site 405955000938 NAD binding site [chemical binding]; other site 405955000939 catalytic residues [active] 405955000940 transcriptional regulator BetI; Validated; Region: PRK00767 405955000941 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955000942 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 405955000943 choline transport protein BetT; Provisional; Region: PRK09928 405955000944 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955000945 DNA binding residues [nucleotide binding] 405955000946 dimerization interface [polypeptide binding]; other site 405955000947 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955000948 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 405955000949 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955000950 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 405955000951 dimerization interface [polypeptide binding]; other site 405955000952 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 405955000953 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405955000954 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 405955000955 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 405955000956 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 405955000957 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 405955000958 CoA binding domain; Region: CoA_binding; pfam02629 405955000959 CoA-ligase; Region: Ligase_CoA; pfam00549 405955000960 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 405955000961 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 405955000962 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 405955000963 putative substrate binding site [chemical binding]; other site 405955000964 nucleotide binding site [chemical binding]; other site 405955000965 nucleotide binding site [chemical binding]; other site 405955000966 homodimer interface [polypeptide binding]; other site 405955000967 putative deaminase; Validated; Region: PRK06846 405955000968 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 405955000969 active site 405955000970 ASC-1 homology domain, subfamily similar to Enterococcus faecalis Ef3133. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to...; Region: ASCH_Ef3133_like; cd06553 405955000971 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 405955000972 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 405955000973 ligand binding site [chemical binding]; other site 405955000974 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 405955000975 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405955000976 Walker A/P-loop; other site 405955000977 ATP binding site [chemical binding]; other site 405955000978 Q-loop/lid; other site 405955000979 ABC transporter signature motif; other site 405955000980 Walker B; other site 405955000981 D-loop; other site 405955000982 H-loop/switch region; other site 405955000983 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405955000984 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405955000985 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405955000986 TM-ABC transporter signature motif; other site 405955000987 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405955000988 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405955000989 TM-ABC transporter signature motif; other site 405955000990 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 405955000991 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 405955000992 putative NAD(P) binding site [chemical binding]; other site 405955000993 putative substrate binding site [chemical binding]; other site 405955000994 catalytic Zn binding site [ion binding]; other site 405955000995 structural Zn binding site [ion binding]; other site 405955000996 dimer interface [polypeptide binding]; other site 405955000997 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 405955000998 hypothetical protein; Provisional; Region: PRK09929 405955000999 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 405955001000 Propionate catabolism activator; Region: PrpR_N; pfam06506 405955001001 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955001002 Walker A motif; other site 405955001003 ATP binding site [chemical binding]; other site 405955001004 Walker B motif; other site 405955001005 arginine finger; other site 405955001006 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405955001007 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 405955001008 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 405955001009 tetramer interface [polypeptide binding]; other site 405955001010 active site 405955001011 Mg2+/Mn2+ binding site [ion binding]; other site 405955001012 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 405955001013 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 405955001014 dimer interface [polypeptide binding]; other site 405955001015 active site 405955001016 citrylCoA binding site [chemical binding]; other site 405955001017 oxalacetate/citrate binding site [chemical binding]; other site 405955001018 coenzyme A binding site [chemical binding]; other site 405955001019 catalytic triad [active] 405955001020 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 405955001021 2-methylcitrate dehydratase; Region: prpD; TIGR02330 405955001022 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 405955001023 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 405955001024 acyl-activating enzyme (AAE) consensus motif; other site 405955001025 putative AMP binding site [chemical binding]; other site 405955001026 putative active site [active] 405955001027 putative CoA binding site [chemical binding]; other site 405955001028 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 405955001029 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 405955001030 Na binding site [ion binding]; other site 405955001031 putative substrate binding site [chemical binding]; other site 405955001032 cytosine deaminase; Provisional; Region: PRK09230 405955001033 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 405955001034 active site 405955001035 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 405955001036 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 405955001037 active site 405955001038 substrate binding site [chemical binding]; other site 405955001039 trimer interface [polypeptide binding]; other site 405955001040 CoA binding site [chemical binding]; other site 405955001041 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 405955001042 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955001043 putative substrate translocation pore; other site 405955001044 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 405955001045 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 405955001046 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 405955001047 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 405955001048 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 405955001049 lac repressor; Reviewed; Region: lacI; PRK09526 405955001050 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955001051 DNA binding site [nucleotide binding] 405955001052 domain linker motif; other site 405955001053 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 405955001054 ligand binding site [chemical binding]; other site 405955001055 dimerization interface (open form) [polypeptide binding]; other site 405955001056 dimerization interface (closed form) [polypeptide binding]; other site 405955001057 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 405955001058 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 405955001059 S-formylglutathione hydrolase; Region: PLN02442 405955001060 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 405955001061 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 405955001062 substrate binding site [chemical binding]; other site 405955001063 catalytic Zn binding site [ion binding]; other site 405955001064 NAD binding site [chemical binding]; other site 405955001065 structural Zn binding site [ion binding]; other site 405955001066 dimer interface [polypeptide binding]; other site 405955001067 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 405955001068 putative metal binding site [ion binding]; other site 405955001069 putative homodimer interface [polypeptide binding]; other site 405955001070 putative homotetramer interface [polypeptide binding]; other site 405955001071 putative homodimer-homodimer interface [polypeptide binding]; other site 405955001072 putative allosteric switch controlling residues; other site 405955001073 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 405955001074 putative trimer interface [polypeptide binding]; other site 405955001075 putative CoA binding site [chemical binding]; other site 405955001076 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 405955001077 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 405955001078 DXD motif; other site 405955001079 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 405955001080 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 405955001081 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955001082 substrate binding pocket [chemical binding]; other site 405955001083 membrane-bound complex binding site; other site 405955001084 hinge residues; other site 405955001085 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 405955001086 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405955001087 Walker A/P-loop; other site 405955001088 ATP binding site [chemical binding]; other site 405955001089 Q-loop/lid; other site 405955001090 ABC transporter signature motif; other site 405955001091 Walker B; other site 405955001092 D-loop; other site 405955001093 H-loop/switch region; other site 405955001094 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405955001095 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955001096 dimer interface [polypeptide binding]; other site 405955001097 conserved gate region; other site 405955001098 putative PBP binding loops; other site 405955001099 ABC-ATPase subunit interface; other site 405955001100 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 405955001101 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 405955001102 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 405955001103 dimer interface [polypeptide binding]; other site 405955001104 active site 405955001105 Schiff base residues; other site 405955001106 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 405955001107 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 405955001108 Autotransporter beta-domain; Region: Autotransporter; pfam03797 405955001109 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 405955001110 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 405955001111 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405955001112 microcin B17 transporter; Reviewed; Region: PRK11098 405955001113 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 405955001114 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 405955001115 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 405955001116 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 405955001117 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 405955001118 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 405955001119 anti-RssB factor; Provisional; Region: PRK10244 405955001120 alkaline phosphatase; Provisional; Region: PRK10518 405955001121 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 405955001122 dimer interface [polypeptide binding]; other site 405955001123 active site 405955001124 hypothetical protein; Provisional; Region: PRK11505 405955001125 psiF repeat; Region: PsiF_repeat; pfam07769 405955001126 psiF repeat; Region: PsiF_repeat; pfam07769 405955001127 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 405955001128 MASE2 domain; Region: MASE2; pfam05230 405955001129 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955001130 metal binding site [ion binding]; metal-binding site 405955001131 active site 405955001132 I-site; other site 405955001133 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 405955001134 pyrroline-5-carboxylate reductase; Region: PLN02688 405955001135 hypothetical protein; Validated; Region: PRK00124 405955001136 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 405955001137 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 405955001138 ADP binding site [chemical binding]; other site 405955001139 magnesium binding site [ion binding]; other site 405955001140 putative shikimate binding site; other site 405955001141 hypothetical protein; Provisional; Region: PRK10481 405955001142 hypothetical protein; Provisional; Region: PRK10579 405955001143 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 405955001144 fructokinase; Reviewed; Region: PRK09557 405955001145 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405955001146 nucleotide binding site [chemical binding]; other site 405955001147 MFS transport protein AraJ; Provisional; Region: PRK10091 405955001148 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955001149 putative substrate translocation pore; other site 405955001150 exonuclease subunit SbcC; Provisional; Region: PRK10246 405955001151 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955001152 Walker A/P-loop; other site 405955001153 ATP binding site [chemical binding]; other site 405955001154 Q-loop/lid; other site 405955001155 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955001156 ABC transporter signature motif; other site 405955001157 Walker B; other site 405955001158 D-loop; other site 405955001159 H-loop/switch region; other site 405955001160 exonuclease subunit SbcD; Provisional; Region: PRK10966 405955001161 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 405955001162 active site 405955001163 metal binding site [ion binding]; metal-binding site 405955001164 DNA binding site [nucleotide binding] 405955001165 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 405955001166 transcriptional regulator PhoB; Provisional; Region: PRK10161 405955001167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955001168 active site 405955001169 phosphorylation site [posttranslational modification] 405955001170 intermolecular recognition site; other site 405955001171 dimerization interface [polypeptide binding]; other site 405955001172 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955001173 DNA binding site [nucleotide binding] 405955001174 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 405955001175 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 405955001176 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405955001177 putative active site [active] 405955001178 heme pocket [chemical binding]; other site 405955001179 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955001180 dimer interface [polypeptide binding]; other site 405955001181 phosphorylation site [posttranslational modification] 405955001182 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955001183 ATP binding site [chemical binding]; other site 405955001184 Mg2+ binding site [ion binding]; other site 405955001185 G-X-G motif; other site 405955001186 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 405955001187 putative proline-specific permease; Provisional; Region: proY; PRK10580 405955001188 Spore germination protein; Region: Spore_permease; cl17796 405955001189 maltodextrin glucosidase; Provisional; Region: PRK10785 405955001190 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 405955001191 homodimer interface [polypeptide binding]; other site 405955001192 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 405955001193 active site 405955001194 homodimer interface [polypeptide binding]; other site 405955001195 catalytic site [active] 405955001196 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 405955001197 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 405955001198 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 405955001199 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 405955001200 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 405955001201 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 405955001202 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 405955001203 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 405955001204 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 405955001205 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 405955001206 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 405955001207 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 405955001208 Protein export membrane protein; Region: SecD_SecF; pfam02355 405955001209 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405955001210 active site 405955001211 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 405955001212 hypothetical protein; Provisional; Region: PRK11530 405955001213 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 405955001214 ATP cone domain; Region: ATP-cone; pfam03477 405955001215 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 405955001216 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 405955001217 catalytic motif [active] 405955001218 Zn binding site [ion binding]; other site 405955001219 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 405955001220 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 405955001221 homopentamer interface [polypeptide binding]; other site 405955001222 active site 405955001223 thiamine monophosphate kinase; Provisional; Region: PRK05731 405955001224 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 405955001225 ATP binding site [chemical binding]; other site 405955001226 dimerization interface [polypeptide binding]; other site 405955001227 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 405955001228 tetramer interfaces [polypeptide binding]; other site 405955001229 binuclear metal-binding site [ion binding]; other site 405955001230 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405955001231 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405955001232 active site 405955001233 catalytic tetrad [active] 405955001234 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 405955001235 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 405955001236 TPP-binding site; other site 405955001237 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405955001238 PYR/PP interface [polypeptide binding]; other site 405955001239 dimer interface [polypeptide binding]; other site 405955001240 TPP binding site [chemical binding]; other site 405955001241 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405955001242 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 405955001243 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 405955001244 substrate binding pocket [chemical binding]; other site 405955001245 chain length determination region; other site 405955001246 substrate-Mg2+ binding site; other site 405955001247 catalytic residues [active] 405955001248 aspartate-rich region 1; other site 405955001249 active site lid residues [active] 405955001250 aspartate-rich region 2; other site 405955001251 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 405955001252 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 405955001253 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 405955001254 Ligand Binding Site [chemical binding]; other site 405955001255 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405955001256 active site residue [active] 405955001257 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 405955001258 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 405955001259 conserved cys residue [active] 405955001260 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 405955001261 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 405955001262 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 405955001263 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 405955001264 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 405955001265 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955001266 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405955001267 putative substrate translocation pore; other site 405955001268 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 405955001269 UbiA prenyltransferase family; Region: UbiA; pfam01040 405955001270 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 405955001271 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 405955001272 Subunit I/III interface [polypeptide binding]; other site 405955001273 Subunit III/IV interface [polypeptide binding]; other site 405955001274 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 405955001275 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 405955001276 D-pathway; other site 405955001277 Putative ubiquinol binding site [chemical binding]; other site 405955001278 Low-spin heme (heme b) binding site [chemical binding]; other site 405955001279 Putative water exit pathway; other site 405955001280 Binuclear center (heme o3/CuB) [ion binding]; other site 405955001281 K-pathway; other site 405955001282 Putative proton exit pathway; other site 405955001283 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 405955001284 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 405955001285 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 405955001286 muropeptide transporter; Reviewed; Region: ampG; PRK11902 405955001287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955001288 putative substrate translocation pore; other site 405955001289 hypothetical protein; Provisional; Region: PRK11627 405955001290 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 405955001291 transcriptional regulator BolA; Provisional; Region: PRK11628 405955001292 trigger factor; Provisional; Region: tig; PRK01490 405955001293 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 405955001294 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 405955001295 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 405955001296 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 405955001297 oligomer interface [polypeptide binding]; other site 405955001298 active site residues [active] 405955001299 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 405955001300 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 405955001301 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955001302 Walker A motif; other site 405955001303 ATP binding site [chemical binding]; other site 405955001304 Walker B motif; other site 405955001305 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405955001306 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 405955001307 Found in ATP-dependent protease La (LON); Region: LON; smart00464 405955001308 Found in ATP-dependent protease La (LON); Region: LON; smart00464 405955001309 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955001310 Walker A motif; other site 405955001311 ATP binding site [chemical binding]; other site 405955001312 Walker B motif; other site 405955001313 arginine finger; other site 405955001314 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 405955001315 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405955001316 IHF dimer interface [polypeptide binding]; other site 405955001317 IHF - DNA interface [nucleotide binding]; other site 405955001318 periplasmic folding chaperone; Provisional; Region: PRK10788 405955001319 SurA N-terminal domain; Region: SurA_N_3; cl07813 405955001320 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 405955001321 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 405955001322 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 405955001323 active site 405955001324 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 405955001325 Ligand Binding Site [chemical binding]; other site 405955001326 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 405955001327 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 405955001328 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 405955001329 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 405955001330 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955001331 active site 405955001332 motif I; other site 405955001333 motif II; other site 405955001334 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405955001335 dimerization interface [polypeptide binding]; other site 405955001336 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 405955001337 putative DNA binding site [nucleotide binding]; other site 405955001338 putative Zn2+ binding site [ion binding]; other site 405955001339 AsnC family; Region: AsnC_trans_reg; pfam01037 405955001340 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405955001341 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 405955001342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955001343 Walker A/P-loop; other site 405955001344 ATP binding site [chemical binding]; other site 405955001345 Q-loop/lid; other site 405955001346 ABC transporter signature motif; other site 405955001347 Walker B; other site 405955001348 D-loop; other site 405955001349 H-loop/switch region; other site 405955001350 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 405955001351 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405955001352 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 405955001353 Walker A/P-loop; other site 405955001354 ATP binding site [chemical binding]; other site 405955001355 Q-loop/lid; other site 405955001356 ABC transporter signature motif; other site 405955001357 Walker B; other site 405955001358 D-loop; other site 405955001359 H-loop/switch region; other site 405955001360 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 405955001361 Nitrogen regulatory protein P-II; Region: P-II; smart00938 405955001362 ammonium transporter; Provisional; Region: PRK10666 405955001363 acyl-CoA thioesterase II; Provisional; Region: PRK10526 405955001364 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 405955001365 active site 405955001366 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 405955001367 catalytic triad [active] 405955001368 dimer interface [polypeptide binding]; other site 405955001369 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 405955001370 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 405955001371 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 405955001372 DNA binding site [nucleotide binding] 405955001373 active site 405955001374 Uncharacterized conserved protein [Function unknown]; Region: COG5507 405955001375 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 405955001376 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 405955001377 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955001378 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 405955001379 maltose O-acetyltransferase; Provisional; Region: PRK10092 405955001380 Maltose acetyltransferase; Region: Mac; pfam12464 405955001381 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 405955001382 trimer interface [polypeptide binding]; other site 405955001383 active site 405955001384 substrate binding site [chemical binding]; other site 405955001385 CoA binding site [chemical binding]; other site 405955001386 gene expression modulator; Provisional; Region: PRK10945 405955001387 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 405955001388 Protein export membrane protein; Region: SecD_SecF; cl14618 405955001389 Protein export membrane protein; Region: SecD_SecF; cl14618 405955001390 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 405955001391 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955001392 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955001393 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 405955001394 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955001395 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 405955001396 hypothetical protein; Provisional; Region: PRK11281 405955001397 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 405955001398 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 405955001399 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405955001400 primosomal replication protein N''; Provisional; Region: PRK10093 405955001401 hypothetical protein; Provisional; Region: PRK10527 405955001402 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405955001403 active site 405955001404 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 405955001405 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955001406 Walker A motif; other site 405955001407 ATP binding site [chemical binding]; other site 405955001408 Walker B motif; other site 405955001409 DNA polymerase III subunit delta'; Validated; Region: PRK08485 405955001410 arginine finger; other site 405955001411 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 405955001412 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 405955001413 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 405955001414 hypothetical protein; Validated; Region: PRK00153 405955001415 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 405955001416 RecR protein; Region: RecR; pfam02132 405955001417 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 405955001418 putative active site [active] 405955001419 putative metal-binding site [ion binding]; other site 405955001420 tetramer interface [polypeptide binding]; other site 405955001421 heat shock protein 90; Provisional; Region: PRK05218 405955001422 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955001423 ATP binding site [chemical binding]; other site 405955001424 Mg2+ binding site [ion binding]; other site 405955001425 G-X-G motif; other site 405955001426 adenylate kinase; Reviewed; Region: adk; PRK00279 405955001427 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 405955001428 AMP-binding site [chemical binding]; other site 405955001429 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 405955001430 ferrochelatase; Region: hemH; TIGR00109 405955001431 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 405955001432 C-terminal domain interface [polypeptide binding]; other site 405955001433 active site 405955001434 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 405955001435 active site 405955001436 N-terminal domain interface [polypeptide binding]; other site 405955001437 acetyl esterase; Provisional; Region: PRK10162 405955001438 inosine/guanosine kinase; Provisional; Region: PRK15074 405955001439 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405955001440 putative cation:proton antiport protein; Provisional; Region: PRK10669 405955001441 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 405955001442 TrkA-N domain; Region: TrkA_N; pfam02254 405955001443 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955001444 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405955001445 putative substrate translocation pore; other site 405955001446 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 405955001447 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 405955001448 active site 405955001449 metal binding site [ion binding]; metal-binding site 405955001450 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405955001451 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 405955001452 putative deacylase active site [active] 405955001453 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 405955001454 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 405955001455 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 405955001456 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955001457 non-specific DNA binding site [nucleotide binding]; other site 405955001458 salt bridge; other site 405955001459 sequence-specific DNA binding site [nucleotide binding]; other site 405955001460 copper exporting ATPase; Provisional; Region: copA; PRK10671 405955001461 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405955001462 metal-binding site [ion binding] 405955001463 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405955001464 metal-binding site [ion binding] 405955001465 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405955001466 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955001467 motif II; other site 405955001468 glutaminase; Reviewed; Region: PRK12356 405955001469 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 405955001470 amino acid transporter; Region: 2A0306; TIGR00909 405955001471 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 405955001472 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 405955001473 DNA binding residues [nucleotide binding] 405955001474 dimer interface [polypeptide binding]; other site 405955001475 copper binding site [ion binding]; other site 405955001476 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 405955001477 YadA-like C-terminal region; Region: YadA; pfam03895 405955001478 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 405955001479 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 405955001480 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 405955001481 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 405955001482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955001483 Walker A/P-loop; other site 405955001484 ATP binding site [chemical binding]; other site 405955001485 Q-loop/lid; other site 405955001486 ABC transporter signature motif; other site 405955001487 Walker B; other site 405955001488 D-loop; other site 405955001489 H-loop/switch region; other site 405955001490 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 405955001491 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 405955001492 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 405955001493 oxidoreductase; Provisional; Region: PRK08017 405955001494 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 405955001495 NADP binding site [chemical binding]; other site 405955001496 active site 405955001497 steroid binding site; other site 405955001498 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 405955001499 active site 405955001500 catalytic triad [active] 405955001501 oxyanion hole [active] 405955001502 switch loop; other site 405955001503 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 405955001504 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405955001505 Walker A/P-loop; other site 405955001506 ATP binding site [chemical binding]; other site 405955001507 Q-loop/lid; other site 405955001508 ABC transporter signature motif; other site 405955001509 Walker B; other site 405955001510 D-loop; other site 405955001511 H-loop/switch region; other site 405955001512 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 405955001513 FtsX-like permease family; Region: FtsX; pfam02687 405955001514 FtsX-like permease family; Region: FtsX; pfam02687 405955001515 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 405955001516 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 405955001517 active site residue [active] 405955001518 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 405955001519 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955001520 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 405955001521 dimerization interface [polypeptide binding]; other site 405955001522 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 405955001523 ureidoglycolate hydrolase; Provisional; Region: PRK03606 405955001524 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 405955001525 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 405955001526 Bacterial transcriptional regulator; Region: IclR; pfam01614 405955001527 glyoxylate carboligase; Provisional; Region: PRK11269 405955001528 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405955001529 PYR/PP interface [polypeptide binding]; other site 405955001530 dimer interface [polypeptide binding]; other site 405955001531 TPP binding site [chemical binding]; other site 405955001532 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405955001533 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 405955001534 TPP-binding site [chemical binding]; other site 405955001535 hydroxypyruvate isomerase; Provisional; Region: PRK09997 405955001536 tartronate semialdehyde reductase; Provisional; Region: PRK15059 405955001537 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405955001538 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 405955001539 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 405955001540 Na binding site [ion binding]; other site 405955001541 substrate binding site [chemical binding]; other site 405955001542 allantoinase; Provisional; Region: PRK08044 405955001543 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 405955001544 active site 405955001545 putative uracil/xanthine transporter; Provisional; Region: PRK11412 405955001546 glycerate kinase II; Provisional; Region: PRK09932 405955001547 putative allantoin catabolism protein; Region: ura-cupin; TIGR03214 405955001548 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 405955001549 Cupin domain; Region: Cupin_2; cl17218 405955001550 allantoate amidohydrolase; Region: AllC; TIGR03176 405955001551 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 405955001552 active site 405955001553 metal binding site [ion binding]; metal-binding site 405955001554 dimer interface [polypeptide binding]; other site 405955001555 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 405955001556 membrane protein FdrA; Validated; Region: PRK06091 405955001557 CoA binding domain; Region: CoA_binding; pfam02629 405955001558 CoA-ligase; Region: Ligase_CoA; pfam00549 405955001559 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 405955001560 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 405955001561 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 405955001562 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 405955001563 putative substrate binding site [chemical binding]; other site 405955001564 nucleotide binding site [chemical binding]; other site 405955001565 nucleotide binding site [chemical binding]; other site 405955001566 homodimer interface [polypeptide binding]; other site 405955001567 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 405955001568 ATP-grasp domain; Region: ATP-grasp; pfam02222 405955001569 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 405955001570 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 405955001571 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405955001572 putative active site [active] 405955001573 putative metal binding site [ion binding]; other site 405955001574 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 405955001575 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 405955001576 active site 405955001577 HIGH motif; other site 405955001578 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 405955001579 KMSKS motif; other site 405955001580 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 405955001581 tRNA binding surface [nucleotide binding]; other site 405955001582 anticodon binding site; other site 405955001583 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 405955001584 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 405955001585 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 405955001586 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 405955001587 homodimer interface [polypeptide binding]; other site 405955001588 NADP binding site [chemical binding]; other site 405955001589 substrate binding site [chemical binding]; other site 405955001590 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405955001591 DNA binding site [nucleotide binding] 405955001592 active site 405955001593 Int/Topo IB signature motif; other site 405955001594 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405955001595 Methyltransferase domain; Region: Methyltransf_12; pfam08242 405955001596 S-adenosylmethionine binding site [chemical binding]; other site 405955001597 outer membrane protease; Reviewed; Region: PRK10993 405955001598 hypothetical protein; Provisional; Region: PRK09936 405955001599 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 405955001600 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405955001601 TPR motif; other site 405955001602 binding surface 405955001603 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 405955001604 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 405955001605 active site 405955001606 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 405955001607 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 405955001608 sensor kinase CusS; Provisional; Region: PRK09835 405955001609 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405955001610 dimerization interface [polypeptide binding]; other site 405955001611 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955001612 dimer interface [polypeptide binding]; other site 405955001613 phosphorylation site [posttranslational modification] 405955001614 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955001615 ATP binding site [chemical binding]; other site 405955001616 Mg2+ binding site [ion binding]; other site 405955001617 G-X-G motif; other site 405955001618 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 405955001619 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955001620 active site 405955001621 phosphorylation site [posttranslational modification] 405955001622 intermolecular recognition site; other site 405955001623 dimerization interface [polypeptide binding]; other site 405955001624 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955001625 DNA binding site [nucleotide binding] 405955001626 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 405955001627 periplasmic copper-binding protein; Provisional; Region: PRK09838 405955001628 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 405955001629 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955001630 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 405955001631 phenylalanine transporter; Provisional; Region: PRK10249 405955001632 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 405955001633 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405955001634 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 405955001635 dimer interface [polypeptide binding]; other site 405955001636 FMN binding site [chemical binding]; other site 405955001637 hypothetical protein; Provisional; Region: PRK10250 405955001638 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 405955001639 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 405955001640 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 405955001641 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 405955001642 outer membrane receptor FepA; Provisional; Region: PRK13524 405955001643 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 405955001644 N-terminal plug; other site 405955001645 ligand-binding site [chemical binding]; other site 405955001646 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 405955001647 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 405955001648 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405955001649 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 405955001650 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 405955001651 acyl-activating enzyme (AAE) consensus motif; other site 405955001652 AMP binding site [chemical binding]; other site 405955001653 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405955001654 LPS O-antigen length regulator; Provisional; Region: PRK10381 405955001655 Chain length determinant protein; Region: Wzz; pfam02706 405955001656 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 405955001657 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 405955001658 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405955001659 Walker A/P-loop; other site 405955001660 ATP binding site [chemical binding]; other site 405955001661 Q-loop/lid; other site 405955001662 ABC transporter signature motif; other site 405955001663 Walker B; other site 405955001664 D-loop; other site 405955001665 H-loop/switch region; other site 405955001666 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405955001667 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955001668 ABC-ATPase subunit interface; other site 405955001669 dimer interface [polypeptide binding]; other site 405955001670 putative PBP binding regions; other site 405955001671 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405955001672 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955001673 ABC-ATPase subunit interface; other site 405955001674 dimer interface [polypeptide binding]; other site 405955001675 putative PBP binding regions; other site 405955001676 enterobactin exporter EntS; Provisional; Region: PRK10489 405955001677 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955001678 putative substrate translocation pore; other site 405955001679 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 405955001680 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 405955001681 siderophore binding site; other site 405955001682 isochorismate synthase EntC; Provisional; Region: PRK15016 405955001683 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405955001684 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 405955001685 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 405955001686 acyl-activating enzyme (AAE) consensus motif; other site 405955001687 active site 405955001688 AMP binding site [chemical binding]; other site 405955001689 substrate binding site [chemical binding]; other site 405955001690 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 405955001691 hydrophobic substrate binding pocket; other site 405955001692 Isochorismatase family; Region: Isochorismatase; pfam00857 405955001693 active site 405955001694 conserved cis-peptide bond; other site 405955001695 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 405955001696 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 405955001697 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 405955001698 putative NAD(P) binding site [chemical binding]; other site 405955001699 active site 405955001700 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 405955001701 CoenzymeA binding site [chemical binding]; other site 405955001702 subunit interaction site [polypeptide binding]; other site 405955001703 PHB binding site; other site 405955001704 carbon starvation protein A; Provisional; Region: PRK15015 405955001705 Carbon starvation protein CstA; Region: CstA; pfam02554 405955001706 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 405955001707 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 405955001708 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 405955001709 putative active site [active] 405955001710 metal binding site [ion binding]; metal-binding site 405955001711 methionine aminotransferase; Validated; Region: PRK09082 405955001712 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405955001713 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955001714 homodimer interface [polypeptide binding]; other site 405955001715 catalytic residue [active] 405955001716 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 405955001717 ParB-like nuclease domain; Region: ParBc; pfam02195 405955001718 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 405955001719 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 405955001720 Active Sites [active] 405955001721 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 405955001722 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 405955001723 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955001724 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 405955001725 dimerization interface [polypeptide binding]; other site 405955001726 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 405955001727 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 405955001728 dimerization domain [polypeptide binding]; other site 405955001729 dimer interface [polypeptide binding]; other site 405955001730 catalytic residues [active] 405955001731 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 405955001732 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 405955001733 dimer interface [polypeptide binding]; other site 405955001734 decamer (pentamer of dimers) interface [polypeptide binding]; other site 405955001735 catalytic triad [active] 405955001736 peroxidatic and resolving cysteines [active] 405955001737 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 405955001738 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 405955001739 catalytic residue [active] 405955001740 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 405955001741 catalytic residues [active] 405955001742 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405955001743 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955001744 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405955001745 Ligand Binding Site [chemical binding]; other site 405955001746 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 405955001747 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 405955001748 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 405955001749 B1 nucleotide binding pocket [chemical binding]; other site 405955001750 B2 nucleotide binding pocket [chemical binding]; other site 405955001751 CAS motifs; other site 405955001752 active site 405955001753 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 405955001754 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 405955001755 transmembrane helices; other site 405955001756 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 405955001757 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 405955001758 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 405955001759 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 405955001760 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 405955001761 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 405955001762 putative active site [active] 405955001763 (T/H)XGH motif; other site 405955001764 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 405955001765 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405955001766 putative active site [active] 405955001767 heme pocket [chemical binding]; other site 405955001768 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955001769 ATP binding site [chemical binding]; other site 405955001770 Mg2+ binding site [ion binding]; other site 405955001771 G-X-G motif; other site 405955001772 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 405955001773 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955001774 active site 405955001775 phosphorylation site [posttranslational modification] 405955001776 intermolecular recognition site; other site 405955001777 dimerization interface [polypeptide binding]; other site 405955001778 Transcriptional regulator; Region: CitT; pfam12431 405955001779 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 405955001780 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 405955001781 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 405955001782 chromosome condensation membrane protein; Provisional; Region: PRK14196 405955001783 Predicted amidohydrolase [General function prediction only]; Region: COG0388 405955001784 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 405955001785 putative active site [active] 405955001786 catalytic triad [active] 405955001787 putative dimer interface [polypeptide binding]; other site 405955001788 lipoyl synthase; Provisional; Region: PRK05481 405955001789 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955001790 FeS/SAM binding site; other site 405955001791 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 405955001792 lipoate-protein ligase B; Provisional; Region: PRK14342 405955001793 hypothetical protein; Provisional; Region: PRK04998 405955001794 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 405955001795 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405955001796 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 405955001797 rare lipoprotein A; Provisional; Region: PRK10672 405955001798 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 405955001799 Sporulation related domain; Region: SPOR; pfam05036 405955001800 cell wall shape-determining protein; Provisional; Region: PRK10794 405955001801 penicillin-binding protein 2; Provisional; Region: PRK10795 405955001802 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 405955001803 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 405955001804 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 405955001805 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405955001806 catalytic core [active] 405955001807 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 405955001808 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 405955001809 active site 405955001810 (T/H)XGH motif; other site 405955001811 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 405955001812 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 405955001813 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 405955001814 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 405955001815 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 405955001816 HIGH motif; other site 405955001817 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405955001818 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405955001819 active site 405955001820 KMSKS motif; other site 405955001821 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 405955001822 tRNA binding surface [nucleotide binding]; other site 405955001823 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 405955001824 hypothetical protein; Provisional; Region: PRK11032 405955001825 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 405955001826 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 405955001827 active site 405955001828 tetramer interface [polypeptide binding]; other site 405955001829 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405955001830 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405955001831 Walker A/P-loop; other site 405955001832 ATP binding site [chemical binding]; other site 405955001833 Q-loop/lid; other site 405955001834 ABC transporter signature motif; other site 405955001835 Walker B; other site 405955001836 D-loop; other site 405955001837 H-loop/switch region; other site 405955001838 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405955001839 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955001840 dimer interface [polypeptide binding]; other site 405955001841 conserved gate region; other site 405955001842 putative PBP binding loops; other site 405955001843 ABC-ATPase subunit interface; other site 405955001844 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405955001845 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955001846 dimer interface [polypeptide binding]; other site 405955001847 conserved gate region; other site 405955001848 putative PBP binding loops; other site 405955001849 ABC-ATPase subunit interface; other site 405955001850 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 405955001851 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955001852 substrate binding pocket [chemical binding]; other site 405955001853 membrane-bound complex binding site; other site 405955001854 hinge residues; other site 405955001855 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 405955001856 Uncharacterized conserved protein [Function unknown]; Region: COG3391 405955001857 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 405955001858 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 405955001859 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 405955001860 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 405955001861 putative active site [active] 405955001862 catalytic triad [active] 405955001863 putative dimer interface [polypeptide binding]; other site 405955001864 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 405955001865 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405955001866 Transporter associated domain; Region: CorC_HlyC; smart01091 405955001867 metal-binding heat shock protein; Provisional; Region: PRK00016 405955001868 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 405955001869 PhoH-like protein; Region: PhoH; pfam02562 405955001870 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 405955001871 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 405955001872 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955001873 FeS/SAM binding site; other site 405955001874 TRAM domain; Region: TRAM; pfam01938 405955001875 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 405955001876 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 405955001877 asparagine synthetase B; Provisional; Region: asnB; PRK09431 405955001878 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 405955001879 active site 405955001880 dimer interface [polypeptide binding]; other site 405955001881 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 405955001882 Ligand Binding Site [chemical binding]; other site 405955001883 Molecular Tunnel; other site 405955001884 UMP phosphatase; Provisional; Region: PRK10444 405955001885 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955001886 active site 405955001887 motif I; other site 405955001888 motif II; other site 405955001889 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955001890 MarR family; Region: MarR; pfam01047 405955001891 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 405955001892 ROK family; Region: ROK; pfam00480 405955001893 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 405955001894 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 405955001895 active site 405955001896 dimer interface [polypeptide binding]; other site 405955001897 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 405955001898 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 405955001899 active site 405955001900 trimer interface [polypeptide binding]; other site 405955001901 allosteric site; other site 405955001902 active site lid [active] 405955001903 hexamer (dimer of trimers) interface [polypeptide binding]; other site 405955001904 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 405955001905 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405955001906 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405955001907 active site turn [active] 405955001908 phosphorylation site [posttranslational modification] 405955001909 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 405955001910 HPr interaction site; other site 405955001911 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405955001912 active site 405955001913 phosphorylation site [posttranslational modification] 405955001914 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 405955001915 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 405955001916 transmembrane helices; other site 405955001917 Predicted neuraminidase (sialidase) [Carbohydrate transport and metabolism]; Region: COG4692 405955001918 BNR repeat-like domain; Region: BNR_2; pfam13088 405955001919 Integral membrane protein TerC family; Region: TerC; cl10468 405955001920 dihydrodipicolinate synthase; Region: dapA; TIGR00674 405955001921 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 405955001922 inhibitor site; inhibition site 405955001923 active site 405955001924 dimer interface [polypeptide binding]; other site 405955001925 catalytic residue [active] 405955001926 5-hydroxyvalerate dehydrogenase (HVD) catalyzes the oxidation of 5-hydroxyvalerate to 5-oxovalerate with NAD+ as cofactor; Region: HVD; cd08193 405955001927 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 405955001928 putative active site [active] 405955001929 metal binding site [ion binding]; metal-binding site 405955001930 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 405955001931 4-hydroxythreonine-4-phosphate dehydrogenase 2; Provisional; Region: pdxA; PRK03371 405955001932 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 405955001933 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405955001934 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 405955001935 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405955001936 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 405955001937 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405955001938 active site 405955001939 HIGH motif; other site 405955001940 nucleotide binding site [chemical binding]; other site 405955001941 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 405955001942 KMSKS motif; other site 405955001943 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 405955001944 outer membrane porin, OprD family; Region: OprD; pfam03573 405955001945 YbfN-like lipoprotein; Region: YbfN; pfam13982 405955001946 ferric uptake regulator; Provisional; Region: fur; PRK09462 405955001947 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 405955001948 metal binding site 2 [ion binding]; metal-binding site 405955001949 putative DNA binding helix; other site 405955001950 metal binding site 1 [ion binding]; metal-binding site 405955001951 dimer interface [polypeptide binding]; other site 405955001952 structural Zn2+ binding site [ion binding]; other site 405955001953 flavodoxin FldA; Validated; Region: PRK09267 405955001954 LexA regulated protein; Provisional; Region: PRK11675 405955001955 acyl-CoA esterase; Provisional; Region: PRK10673 405955001956 PGAP1-like protein; Region: PGAP1; pfam07819 405955001957 replication initiation regulator SeqA; Provisional; Region: PRK11187 405955001958 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 405955001959 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 405955001960 active site 405955001961 substrate binding site [chemical binding]; other site 405955001962 metal binding site [ion binding]; metal-binding site 405955001963 putrescine transporter; Provisional; Region: potE; PRK10655 405955001964 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 405955001965 ornithine decarboxylase; Provisional; Region: PRK13578 405955001966 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 405955001967 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 405955001968 homodimer interface [polypeptide binding]; other site 405955001969 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955001970 catalytic residue [active] 405955001971 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405955001972 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 405955001973 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955001974 active site 405955001975 phosphorylation site [posttranslational modification] 405955001976 intermolecular recognition site; other site 405955001977 dimerization interface [polypeptide binding]; other site 405955001978 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955001979 DNA binding site [nucleotide binding] 405955001980 sensor protein KdpD; Provisional; Region: PRK10490 405955001981 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 405955001982 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 405955001983 Ligand Binding Site [chemical binding]; other site 405955001984 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 405955001985 GAF domain; Region: GAF_3; pfam13492 405955001986 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955001987 dimer interface [polypeptide binding]; other site 405955001988 phosphorylation site [posttranslational modification] 405955001989 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955001990 ATP binding site [chemical binding]; other site 405955001991 Mg2+ binding site [ion binding]; other site 405955001992 G-X-G motif; other site 405955001993 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 405955001994 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 405955001995 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405955001996 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 405955001997 hypothetical protein; Provisional; Region: PRK10167 405955001998 Uncharacterized conserved protein [Function unknown]; Region: COG3272 405955001999 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 405955002000 DNA photolyase; Region: DNA_photolyase; pfam00875 405955002001 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 405955002002 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955002003 putative substrate translocation pore; other site 405955002004 POT family; Region: PTR2; pfam00854 405955002005 Uncharacterized conserved protein [Function unknown]; Region: COG0327 405955002006 metal-binding protein; Provisional; Region: PRK10799 405955002007 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 405955002008 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 405955002009 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 405955002010 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 405955002011 putative active site [active] 405955002012 endonuclease VIII; Provisional; Region: PRK10445 405955002013 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 405955002014 DNA binding site [nucleotide binding] 405955002015 catalytic residue [active] 405955002016 putative catalytic residues [active] 405955002017 H2TH interface [polypeptide binding]; other site 405955002018 intercalation triad [nucleotide binding]; other site 405955002019 substrate specificity determining residue; other site 405955002020 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 405955002021 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 405955002022 Putative ammonia monooxygenase; Region: AmoA; pfam05145 405955002023 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 405955002024 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 405955002025 Fimbrial protein; Region: Fimbrial; pfam00419 405955002026 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 405955002027 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 405955002028 dimer interface [polypeptide binding]; other site 405955002029 active site 405955002030 citrylCoA binding site [chemical binding]; other site 405955002031 NADH binding [chemical binding]; other site 405955002032 cationic pore residues; other site 405955002033 oxalacetate/citrate binding site [chemical binding]; other site 405955002034 coenzyme A binding site [chemical binding]; other site 405955002035 catalytic triad [active] 405955002036 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 405955002037 Iron-sulfur protein interface; other site 405955002038 proximal quinone binding site [chemical binding]; other site 405955002039 SdhD (CybS) interface [polypeptide binding]; other site 405955002040 proximal heme binding site [chemical binding]; other site 405955002041 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 405955002042 SdhC subunit interface [polypeptide binding]; other site 405955002043 proximal heme binding site [chemical binding]; other site 405955002044 cardiolipin binding site; other site 405955002045 Iron-sulfur protein interface; other site 405955002046 proximal quinone binding site [chemical binding]; other site 405955002047 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 405955002048 L-aspartate oxidase; Provisional; Region: PRK06175 405955002049 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 405955002050 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 405955002051 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 405955002052 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 405955002053 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 405955002054 TPP-binding site [chemical binding]; other site 405955002055 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 405955002056 dimer interface [polypeptide binding]; other site 405955002057 PYR/PP interface [polypeptide binding]; other site 405955002058 TPP binding site [chemical binding]; other site 405955002059 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 405955002060 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405955002061 E3 interaction surface; other site 405955002062 lipoyl attachment site [posttranslational modification]; other site 405955002063 e3 binding domain; Region: E3_binding; pfam02817 405955002064 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405955002065 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 405955002066 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 405955002067 CoA-ligase; Region: Ligase_CoA; pfam00549 405955002068 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 405955002069 CoA binding domain; Region: CoA_binding; smart00881 405955002070 CoA-ligase; Region: Ligase_CoA; pfam00549 405955002071 TPR repeat; Region: TPR_11; pfam13414 405955002072 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405955002073 binding surface 405955002074 TPR motif; other site 405955002075 Tetratricopeptide repeat; Region: TPR_12; pfam13424 405955002076 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 405955002077 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 405955002078 hypothetical protein; Provisional; Region: PRK10588 405955002079 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 405955002080 active site 405955002081 colicin uptake protein TolQ; Provisional; Region: PRK10801 405955002082 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 405955002083 colicin uptake protein TolR; Provisional; Region: PRK11024 405955002084 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 405955002085 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 405955002086 TolA C-terminal; Region: TolA; pfam06519 405955002087 translocation protein TolB; Provisional; Region: tolB; PRK03629 405955002088 TolB amino-terminal domain; Region: TolB_N; pfam04052 405955002089 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 405955002090 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 405955002091 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 405955002092 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 405955002093 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405955002094 ligand binding site [chemical binding]; other site 405955002095 tol-pal system protein YbgF; Provisional; Region: PRK10803 405955002096 Tetratricopeptide repeat; Region: TPR_6; pfam13174 405955002097 Tetratricopeptide repeat; Region: TPR_6; pfam13174 405955002098 quinolinate synthetase; Provisional; Region: PRK09375 405955002099 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 405955002100 zinc transporter ZitB; Provisional; Region: PRK03557 405955002101 YbgS-like protein; Region: YbgS; pfam13985 405955002102 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 405955002103 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 405955002104 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405955002105 catalytic core [active] 405955002106 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405955002107 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 405955002108 active site 405955002109 catalytic residues [active] 405955002110 galactokinase; Provisional; Region: PRK05101 405955002111 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 405955002112 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 405955002113 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 405955002114 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 405955002115 dimer interface [polypeptide binding]; other site 405955002116 active site 405955002117 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 405955002118 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 405955002119 NAD binding site [chemical binding]; other site 405955002120 homodimer interface [polypeptide binding]; other site 405955002121 active site 405955002122 substrate binding site [chemical binding]; other site 405955002123 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 405955002124 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 405955002125 Walker A/P-loop; other site 405955002126 ATP binding site [chemical binding]; other site 405955002127 Q-loop/lid; other site 405955002128 ABC transporter signature motif; other site 405955002129 Walker B; other site 405955002130 D-loop; other site 405955002131 H-loop/switch region; other site 405955002132 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955002133 Walker A/P-loop; other site 405955002134 ATP binding site [chemical binding]; other site 405955002135 Q-loop/lid; other site 405955002136 ABC transporter signature motif; other site 405955002137 Walker B; other site 405955002138 D-loop; other site 405955002139 H-loop/switch region; other site 405955002140 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 405955002141 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 405955002142 molybdenum-pterin binding domain; Region: Mop; TIGR00638 405955002143 TOBE domain; Region: TOBE; pfam03459 405955002144 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 405955002145 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955002146 substrate binding pocket [chemical binding]; other site 405955002147 membrane-bound complex binding site; other site 405955002148 hinge residues; other site 405955002149 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 405955002150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955002151 dimer interface [polypeptide binding]; other site 405955002152 conserved gate region; other site 405955002153 putative PBP binding loops; other site 405955002154 ABC-ATPase subunit interface; other site 405955002155 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 405955002156 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955002157 Walker A/P-loop; other site 405955002158 ATP binding site [chemical binding]; other site 405955002159 Q-loop/lid; other site 405955002160 ABC transporter signature motif; other site 405955002161 Walker B; other site 405955002162 D-loop; other site 405955002163 H-loop/switch region; other site 405955002164 molybdenum-pterin binding domain; Region: Mop; TIGR00638 405955002165 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 405955002166 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955002167 motif II; other site 405955002168 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955002169 6-phosphogluconolactonase; Provisional; Region: PRK11028 405955002170 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405955002171 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955002172 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 405955002173 putative dimerization interface [polypeptide binding]; other site 405955002174 PrpF protein; Region: PrpF; pfam04303 405955002175 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 405955002176 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 405955002177 transmembrane helices; other site 405955002178 putative hydratase; Provisional; Region: PRK11413 405955002179 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 405955002180 substrate binding site [chemical binding]; other site 405955002181 ligand binding site [chemical binding]; other site 405955002182 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 405955002183 substrate binding site [chemical binding]; other site 405955002184 acyl-CoA thioesterase; Provisional; Region: PRK10531 405955002185 putative pectinesterase; Region: PLN02432; cl01911 405955002186 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 405955002187 substrate binding site [chemical binding]; other site 405955002188 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 405955002189 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405955002190 inhibitor-cofactor binding pocket; inhibition site 405955002191 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955002192 catalytic residue [active] 405955002193 biotin synthase; Provisional; Region: PRK15108 405955002194 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955002195 FeS/SAM binding site; other site 405955002196 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 405955002197 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 405955002198 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 405955002199 substrate-cofactor binding pocket; other site 405955002200 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955002201 catalytic residue [active] 405955002202 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 405955002203 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955002204 S-adenosylmethionine binding site [chemical binding]; other site 405955002205 AAA domain; Region: AAA_26; pfam13500 405955002206 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405955002207 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 405955002208 ADP binding site [chemical binding]; other site 405955002209 excinuclease ABC subunit B; Provisional; Region: PRK05298 405955002210 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405955002211 ATP binding site [chemical binding]; other site 405955002212 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405955002213 nucleotide binding region [chemical binding]; other site 405955002214 ATP-binding site [chemical binding]; other site 405955002215 Ultra-violet resistance protein B; Region: UvrB; pfam12344 405955002216 UvrB/uvrC motif; Region: UVR; pfam02151 405955002217 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 405955002218 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 405955002219 putative substrate binding pocket [chemical binding]; other site 405955002220 dimer interface [polypeptide binding]; other site 405955002221 phosphate binding site [ion binding]; other site 405955002222 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 405955002223 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955002224 FeS/SAM binding site; other site 405955002225 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 405955002226 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 405955002227 MPT binding site; other site 405955002228 trimer interface [polypeptide binding]; other site 405955002229 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 405955002230 trimer interface [polypeptide binding]; other site 405955002231 dimer interface [polypeptide binding]; other site 405955002232 putative active site [active] 405955002233 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 405955002234 MoaE homodimer interface [polypeptide binding]; other site 405955002235 MoaD interaction [polypeptide binding]; other site 405955002236 active site residues [active] 405955002237 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 405955002238 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 405955002239 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 405955002240 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 405955002241 Predicted integral membrane protein [Function unknown]; Region: COG0392 405955002242 cardiolipin synthase 2; Provisional; Region: PRK11263 405955002243 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 405955002244 putative active site [active] 405955002245 catalytic site [active] 405955002246 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 405955002247 putative active site [active] 405955002248 catalytic site [active] 405955002249 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 405955002250 putative catalytic site [active] 405955002251 putative metal binding site [ion binding]; other site 405955002252 putative phosphate binding site [ion binding]; other site 405955002253 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 405955002254 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 405955002255 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405955002256 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 405955002257 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 405955002258 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 405955002259 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405955002260 Walker A/P-loop; other site 405955002261 ATP binding site [chemical binding]; other site 405955002262 Q-loop/lid; other site 405955002263 ABC transporter signature motif; other site 405955002264 Walker B; other site 405955002265 D-loop; other site 405955002266 H-loop/switch region; other site 405955002267 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 405955002268 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405955002269 Walker A/P-loop; other site 405955002270 ATP binding site [chemical binding]; other site 405955002271 Q-loop/lid; other site 405955002272 ABC transporter signature motif; other site 405955002273 Walker B; other site 405955002274 D-loop; other site 405955002275 H-loop/switch region; other site 405955002276 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 405955002277 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955002278 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955002279 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 405955002280 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 405955002281 ATP-dependent RNA helicase RhlE; Provisional; Region: PRK10590 405955002282 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405955002283 ATP binding site [chemical binding]; other site 405955002284 Mg++ binding site [ion binding]; other site 405955002285 motif III; other site 405955002286 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405955002287 nucleotide binding region [chemical binding]; other site 405955002288 ATP-binding site [chemical binding]; other site 405955002289 Domain of unknown function (DUF1768); Region: DUF1768; cl01271 405955002290 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 405955002291 DEAD_2; Region: DEAD_2; pfam06733 405955002292 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 405955002293 glycosyl transferase family protein; Provisional; Region: PRK08136 405955002294 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405955002295 putative dehydrogenase; Provisional; Region: PRK10098 405955002296 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 405955002297 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 405955002298 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 405955002299 N-terminal plug; other site 405955002300 ligand-binding site [chemical binding]; other site 405955002301 hypothetical protein; Provisional; Region: PRK10259 405955002302 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 405955002303 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 405955002304 putative mechanosensitive channel protein; Provisional; Region: PRK11465 405955002305 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405955002306 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 405955002307 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405955002308 Walker A/P-loop; other site 405955002309 ATP binding site [chemical binding]; other site 405955002310 Q-loop/lid; other site 405955002311 ABC transporter signature motif; other site 405955002312 Walker B; other site 405955002313 D-loop; other site 405955002314 H-loop/switch region; other site 405955002315 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405955002316 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955002317 dimer interface [polypeptide binding]; other site 405955002318 conserved gate region; other site 405955002319 putative PBP binding loops; other site 405955002320 ABC-ATPase subunit interface; other site 405955002321 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 405955002322 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955002323 substrate binding pocket [chemical binding]; other site 405955002324 membrane-bound complex binding site; other site 405955002325 hinge residues; other site 405955002326 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 405955002327 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 405955002328 dimerization interface [polypeptide binding]; other site 405955002329 DPS ferroxidase diiron center [ion binding]; other site 405955002330 ion pore; other site 405955002331 threonine and homoserine efflux system; Provisional; Region: PRK10532 405955002332 EamA-like transporter family; Region: EamA; pfam00892 405955002333 outer membrane protein X; Provisional; Region: ompX; PRK09408 405955002334 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 405955002335 Sulfatase; Region: Sulfatase; pfam00884 405955002336 manganese transport regulator MntR; Provisional; Region: PRK11050 405955002337 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 405955002338 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 405955002339 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 405955002340 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 405955002341 transmembrane helices; other site 405955002342 L,D-transpeptidase; Provisional; Region: PRK10260 405955002343 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405955002344 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 405955002345 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955002346 Walker A/P-loop; other site 405955002347 ATP binding site [chemical binding]; other site 405955002348 Q-loop/lid; other site 405955002349 ABC transporter signature motif; other site 405955002350 Walker B; other site 405955002351 D-loop; other site 405955002352 H-loop/switch region; other site 405955002353 ABC transporter; Region: ABC_tran_2; pfam12848 405955002354 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405955002355 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 405955002356 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955002357 active site 405955002358 motif I; other site 405955002359 motif II; other site 405955002360 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955002361 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 405955002362 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 405955002363 dimer interface [polypeptide binding]; other site 405955002364 active site 405955002365 glycine loop; other site 405955002366 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 405955002367 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 405955002368 active site 405955002369 intersubunit interactions; other site 405955002370 catalytic residue [active] 405955002371 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 405955002372 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405955002373 ATP binding site [chemical binding]; other site 405955002374 substrate interface [chemical binding]; other site 405955002375 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 405955002376 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 405955002377 dimer interface [polypeptide binding]; other site 405955002378 putative functional site; other site 405955002379 putative MPT binding site; other site 405955002380 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 405955002381 catalytic nucleophile [active] 405955002382 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 405955002383 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955002384 Walker A/P-loop; other site 405955002385 ATP binding site [chemical binding]; other site 405955002386 Q-loop/lid; other site 405955002387 ABC transporter signature motif; other site 405955002388 Walker B; other site 405955002389 D-loop; other site 405955002390 H-loop/switch region; other site 405955002391 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405955002392 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955002393 Walker A/P-loop; other site 405955002394 ATP binding site [chemical binding]; other site 405955002395 Q-loop/lid; other site 405955002396 ABC transporter signature motif; other site 405955002397 Walker B; other site 405955002398 D-loop; other site 405955002399 H-loop/switch region; other site 405955002400 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 405955002401 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 405955002402 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 405955002403 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 405955002404 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955002405 dimer interface [polypeptide binding]; other site 405955002406 conserved gate region; other site 405955002407 putative PBP binding loops; other site 405955002408 ABC-ATPase subunit interface; other site 405955002409 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 405955002410 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405955002411 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955002412 dimer interface [polypeptide binding]; other site 405955002413 conserved gate region; other site 405955002414 putative PBP binding loops; other site 405955002415 ABC-ATPase subunit interface; other site 405955002416 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955002417 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405955002418 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955002419 metal binding site [ion binding]; metal-binding site 405955002420 active site 405955002421 I-site; other site 405955002422 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 405955002423 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 405955002424 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955002425 FeS/SAM binding site; other site 405955002426 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 405955002427 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 405955002428 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 405955002429 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 405955002430 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 405955002431 putative C-terminal domain interface [polypeptide binding]; other site 405955002432 putative GSH binding site (G-site) [chemical binding]; other site 405955002433 putative dimer interface [polypeptide binding]; other site 405955002434 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 405955002435 N-terminal domain interface [polypeptide binding]; other site 405955002436 dimer interface [polypeptide binding]; other site 405955002437 substrate binding pocket (H-site) [chemical binding]; other site 405955002438 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 405955002439 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405955002440 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 405955002441 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 405955002442 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 405955002443 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405955002444 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 405955002445 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405955002446 active site 405955002447 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 405955002448 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955002449 putative substrate translocation pore; other site 405955002450 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 405955002451 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955002452 active site 405955002453 motif I; other site 405955002454 motif II; other site 405955002455 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955002456 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955002457 putative substrate translocation pore; other site 405955002458 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405955002459 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 405955002460 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955002461 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 405955002462 putative transporter; Provisional; Region: PRK04972 405955002463 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 405955002464 TrkA-C domain; Region: TrkA_C; pfam02080 405955002465 TrkA-C domain; Region: TrkA_C; pfam02080 405955002466 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 405955002467 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 405955002468 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 405955002469 GSH binding site [chemical binding]; other site 405955002470 catalytic residues [active] 405955002471 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 405955002472 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 405955002473 dimer interface [polypeptide binding]; other site 405955002474 FMN binding site [chemical binding]; other site 405955002475 NADPH bind site [chemical binding]; other site 405955002476 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 405955002477 RimK-like ATP-grasp domain; Region: RimK; pfam08443 405955002478 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 405955002479 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 405955002480 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 405955002481 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 405955002482 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955002483 Walker A/P-loop; other site 405955002484 ATP binding site [chemical binding]; other site 405955002485 Q-loop/lid; other site 405955002486 ABC transporter signature motif; other site 405955002487 Walker B; other site 405955002488 D-loop; other site 405955002489 H-loop/switch region; other site 405955002490 TOBE domain; Region: TOBE_2; pfam08402 405955002491 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 405955002492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955002493 dimer interface [polypeptide binding]; other site 405955002494 conserved gate region; other site 405955002495 putative PBP binding loops; other site 405955002496 ABC-ATPase subunit interface; other site 405955002497 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 405955002498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955002499 dimer interface [polypeptide binding]; other site 405955002500 conserved gate region; other site 405955002501 putative PBP binding loops; other site 405955002502 ABC-ATPase subunit interface; other site 405955002503 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 405955002504 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 405955002505 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955002506 S-adenosylmethionine binding site [chemical binding]; other site 405955002507 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 405955002508 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955002509 substrate binding pocket [chemical binding]; other site 405955002510 membrane-bound complex binding site; other site 405955002511 hinge residues; other site 405955002512 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955002513 dimer interface [polypeptide binding]; other site 405955002514 conserved gate region; other site 405955002515 putative PBP binding loops; other site 405955002516 ABC-ATPase subunit interface; other site 405955002517 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405955002518 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955002519 dimer interface [polypeptide binding]; other site 405955002520 conserved gate region; other site 405955002521 putative PBP binding loops; other site 405955002522 ABC-ATPase subunit interface; other site 405955002523 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 405955002524 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955002525 substrate binding pocket [chemical binding]; other site 405955002526 membrane-bound complex binding site; other site 405955002527 hinge residues; other site 405955002528 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 405955002529 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955002530 Walker A/P-loop; other site 405955002531 ATP binding site [chemical binding]; other site 405955002532 Q-loop/lid; other site 405955002533 ABC transporter signature motif; other site 405955002534 Walker B; other site 405955002535 D-loop; other site 405955002536 H-loop/switch region; other site 405955002537 putative lipoprotein; Provisional; Region: PRK10533 405955002538 hypothetical protein; Provisional; Region: PRK02877 405955002539 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 405955002540 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 405955002541 amidase catalytic site [active] 405955002542 Zn binding residues [ion binding]; other site 405955002543 substrate binding site [chemical binding]; other site 405955002544 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 405955002545 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 405955002546 putative NAD(P) binding site [chemical binding]; other site 405955002547 putative active site [active] 405955002548 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 405955002549 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 405955002550 tetramer interface [polypeptide binding]; other site 405955002551 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955002552 catalytic residue [active] 405955002553 pyruvate dehydrogenase; Provisional; Region: PRK09124 405955002554 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 405955002555 PYR/PP interface [polypeptide binding]; other site 405955002556 dimer interface [polypeptide binding]; other site 405955002557 tetramer interface [polypeptide binding]; other site 405955002558 TPP binding site [chemical binding]; other site 405955002559 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405955002560 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 405955002561 TPP-binding site [chemical binding]; other site 405955002562 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 405955002563 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 405955002564 FAD binding pocket [chemical binding]; other site 405955002565 FAD binding motif [chemical binding]; other site 405955002566 phosphate binding motif [ion binding]; other site 405955002567 beta-alpha-beta structure motif; other site 405955002568 NAD binding pocket [chemical binding]; other site 405955002569 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405955002570 catalytic loop [active] 405955002571 iron binding site [ion binding]; other site 405955002572 hybrid cluster protein; Provisional; Region: PRK05290 405955002573 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405955002574 ACS interaction site; other site 405955002575 CODH interaction site; other site 405955002576 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 405955002577 hybrid metal cluster; other site 405955002578 Predicted membrane protein [Function unknown]; Region: COG2431 405955002579 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 405955002580 amphipathic channel; other site 405955002581 Asn-Pro-Ala signature motifs; other site 405955002582 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 405955002583 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 405955002584 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 405955002585 putative active site [active] 405955002586 putative metal-binding site [ion binding]; other site 405955002587 Protein of unknown function (DUF535); Region: DUF535; pfam04393 405955002588 macrolide transporter subunit MacA; Provisional; Region: PRK11578 405955002589 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955002590 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955002591 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 405955002592 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405955002593 Walker A/P-loop; other site 405955002594 ATP binding site [chemical binding]; other site 405955002595 Q-loop/lid; other site 405955002596 ABC transporter signature motif; other site 405955002597 Walker B; other site 405955002598 D-loop; other site 405955002599 H-loop/switch region; other site 405955002600 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405955002601 FtsX-like permease family; Region: FtsX; pfam02687 405955002602 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 405955002603 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 405955002604 Clp amino terminal domain; Region: Clp_N; pfam02861 405955002605 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955002606 Walker A motif; other site 405955002607 ATP binding site [chemical binding]; other site 405955002608 Walker B motif; other site 405955002609 arginine finger; other site 405955002610 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955002611 Walker A motif; other site 405955002612 ATP binding site [chemical binding]; other site 405955002613 Walker B motif; other site 405955002614 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 405955002615 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-F; cd09718 405955002616 CRISPR/Cas system-associated protein Cas3/Cas2; Region: Cas3_Cas2_I-F; cd09673 405955002617 CRISPR-associated helicase Cas3, subtype I-F/YPEST; Region: cas3_yersinia; TIGR02562 405955002618 CRISPR/Cas system-associated protein Csy1; Region: Csy1_I-F; cd09735 405955002619 CRISPR/Cas system-associated RAMP superfamily protein Csy2; Region: Csy2_I-F; cd09736 405955002620 CRISPR/Cas system-associated RAMP superfamily protein Csy3; Region: Csy3_I-F; cd09737 405955002621 CRISPR/Cas system-associated RAMP superfamily protein Cas6f; Region: Cas6_I-F; cd09739 405955002622 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 405955002623 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 405955002624 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405955002625 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 405955002626 Walker A/P-loop; other site 405955002627 ATP binding site [chemical binding]; other site 405955002628 Q-loop/lid; other site 405955002629 ABC transporter signature motif; other site 405955002630 Walker B; other site 405955002631 D-loop; other site 405955002632 H-loop/switch region; other site 405955002633 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 405955002634 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405955002635 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955002636 Walker A/P-loop; other site 405955002637 ATP binding site [chemical binding]; other site 405955002638 Q-loop/lid; other site 405955002639 ABC transporter signature motif; other site 405955002640 Walker B; other site 405955002641 D-loop; other site 405955002642 H-loop/switch region; other site 405955002643 thioredoxin reductase; Provisional; Region: PRK10262 405955002644 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405955002645 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955002646 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 405955002647 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405955002648 putative DNA binding site [nucleotide binding]; other site 405955002649 putative Zn2+ binding site [ion binding]; other site 405955002650 AsnC family; Region: AsnC_trans_reg; pfam01037 405955002651 DNA translocase FtsK; Provisional; Region: PRK10263 405955002652 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 405955002653 DNA translocase FtsK; Provisional; Region: PRK10263 405955002654 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 405955002655 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 405955002656 periplasmic chaperone LolA; Region: lolA; TIGR00547 405955002657 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 405955002658 recombination factor protein RarA; Reviewed; Region: PRK13342 405955002659 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955002660 Walker A motif; other site 405955002661 ATP binding site [chemical binding]; other site 405955002662 Walker B motif; other site 405955002663 arginine finger; other site 405955002664 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 405955002665 seryl-tRNA synthetase; Provisional; Region: PRK05431 405955002666 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 405955002667 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 405955002668 dimer interface [polypeptide binding]; other site 405955002669 active site 405955002670 motif 1; other site 405955002671 motif 2; other site 405955002672 motif 3; other site 405955002673 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 405955002674 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 405955002675 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 405955002676 putative [Fe4-S4] binding site [ion binding]; other site 405955002677 putative molybdopterin cofactor binding site [chemical binding]; other site 405955002678 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 405955002679 putative molybdopterin cofactor binding site; other site 405955002680 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 405955002681 4Fe-4S binding domain; Region: Fer4; pfam00037 405955002682 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 405955002683 Isochorismatase family; Region: Isochorismatase; pfam00857 405955002684 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 405955002685 catalytic triad [active] 405955002686 dimer interface [polypeptide binding]; other site 405955002687 conserved cis-peptide bond; other site 405955002688 putative MFS family transporter protein; Provisional; Region: PRK03633 405955002689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955002690 putative substrate translocation pore; other site 405955002691 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 405955002692 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955002693 FeS/SAM binding site; other site 405955002694 integrase; Provisional; Region: int; PHA02601 405955002695 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405955002696 active site 405955002697 DNA binding site [nucleotide binding] 405955002698 Int/Topo IB signature motif; other site 405955002699 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955002700 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405955002701 non-specific DNA binding site [nucleotide binding]; other site 405955002702 salt bridge; other site 405955002703 sequence-specific DNA binding site [nucleotide binding]; other site 405955002704 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 405955002705 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 405955002706 AAA domain; Region: AAA_13; pfam13166 405955002707 portal vertex protein; Provisional; Region: Q; PHA02536 405955002708 Phage portal protein; Region: Phage_portal; pfam04860 405955002709 terminase ATPase subunit; Provisional; Region: P; PHA02535 405955002710 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 405955002711 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 405955002712 Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125 405955002713 terminase endonuclease subunit; Provisional; Region: M; PHA02537 405955002714 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 405955002715 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 405955002716 Phage holin family 2; Region: Phage_holin_2; pfam04550 405955002717 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 405955002718 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405955002719 catalytic residue [active] 405955002720 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 405955002721 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 405955002722 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 405955002723 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 405955002724 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 405955002725 baseplate wedge subunit; Provisional; Region: W; PHA02516 405955002726 baseplate assembly protein; Provisional; Region: J; PHA02568 405955002727 Phage tail protein (Tail_P2_I); Region: Tail_P2_I; pfam09684 405955002728 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 405955002729 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 405955002730 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 405955002731 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 405955002732 Phage tail sheath protein; Region: Phage_sheath_1; cl01389 405955002733 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405955002734 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405955002735 DNA binding residues [nucleotide binding] 405955002736 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 405955002737 Integrase core domain; Region: rve; pfam00665 405955002738 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 405955002739 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 405955002740 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955002741 Walker A motif; other site 405955002742 ATP binding site [chemical binding]; other site 405955002743 major tail sheath protein; Provisional; Region: FI; PHA02560 405955002744 major tail tube protein; Provisional; Region: FII; PHA02600 405955002745 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 405955002746 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 405955002747 tail protein; Provisional; Region: D; PHA02561 405955002748 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 405955002749 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 405955002750 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 405955002751 Pyruvate formate lyase 1; Region: PFL1; cd01678 405955002752 coenzyme A binding site [chemical binding]; other site 405955002753 active site 405955002754 catalytic residues [active] 405955002755 glycine loop; other site 405955002756 formate transporter; Provisional; Region: PRK10805 405955002757 uncharacterized domain; Region: TIGR00702 405955002758 YcaO-like family; Region: YcaO; pfam02624 405955002759 Predicted membrane protein [Function unknown]; Region: COG2323 405955002760 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 405955002761 homodimer interface [polypeptide binding]; other site 405955002762 substrate-cofactor binding pocket; other site 405955002763 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955002764 catalytic residue [active] 405955002765 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 405955002766 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 405955002767 hinge; other site 405955002768 active site 405955002769 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 405955002770 cytidylate kinase; Provisional; Region: cmk; PRK00023 405955002771 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 405955002772 CMP-binding site; other site 405955002773 The sites determining sugar specificity; other site 405955002774 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 405955002775 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 405955002776 RNA binding site [nucleotide binding]; other site 405955002777 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 405955002778 RNA binding site [nucleotide binding]; other site 405955002779 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 405955002780 RNA binding site [nucleotide binding]; other site 405955002781 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 405955002782 RNA binding site [nucleotide binding]; other site 405955002783 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 405955002784 RNA binding site [nucleotide binding]; other site 405955002785 Predicted membrane metal-binding protein [General function prediction only]; Region: ComEC; COG0658 405955002786 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 405955002787 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 405955002788 Predicted hydrolase (metallo-beta-lactamase superfamily) [General function prediction only]; Region: ComEC; COG2333 405955002789 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 405955002790 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 405955002791 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405955002792 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 405955002793 Walker A/P-loop; other site 405955002794 ATP binding site [chemical binding]; other site 405955002795 Q-loop/lid; other site 405955002796 ABC transporter signature motif; other site 405955002797 Walker B; other site 405955002798 D-loop; other site 405955002799 H-loop/switch region; other site 405955002800 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 405955002801 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 405955002802 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 405955002803 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 405955002804 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 405955002805 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 405955002806 Ligand binding site; other site 405955002807 oligomer interface; other site 405955002808 hypothetical protein; Provisional; Region: PRK10593 405955002809 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405955002810 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405955002811 putative active site [active] 405955002812 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405955002813 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955002814 S-adenosylmethionine binding site [chemical binding]; other site 405955002815 condesin subunit F; Provisional; Region: PRK05260 405955002816 condesin subunit E; Provisional; Region: PRK05256 405955002817 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 405955002818 MukB N-terminal; Region: MukB; pfam04310 405955002819 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 405955002820 murein L,D-transpeptidase; Provisional; Region: PRK10594 405955002821 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 405955002822 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405955002823 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405955002824 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 405955002825 Peptidase M15; Region: Peptidase_M15_3; cl01194 405955002826 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 405955002827 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 405955002828 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405955002829 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955002830 homodimer interface [polypeptide binding]; other site 405955002831 catalytic residue [active] 405955002832 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 405955002833 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 405955002834 trimer interface [polypeptide binding]; other site 405955002835 eyelet of channel; other site 405955002836 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 405955002837 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 405955002838 putative dimer interface [polypeptide binding]; other site 405955002839 putative anticodon binding site; other site 405955002840 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 405955002841 homodimer interface [polypeptide binding]; other site 405955002842 motif 1; other site 405955002843 motif 2; other site 405955002844 active site 405955002845 motif 3; other site 405955002846 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 405955002847 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 405955002848 active site 405955002849 aminopeptidase N; Provisional; Region: pepN; PRK14015 405955002850 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 405955002851 active site 405955002852 Zn binding site [ion binding]; other site 405955002853 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 405955002854 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 405955002855 Walker A/P-loop; other site 405955002856 ATP binding site [chemical binding]; other site 405955002857 Q-loop/lid; other site 405955002858 ABC transporter signature motif; other site 405955002859 Walker B; other site 405955002860 D-loop; other site 405955002861 H-loop/switch region; other site 405955002862 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405955002863 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955002864 dimer interface [polypeptide binding]; other site 405955002865 conserved gate region; other site 405955002866 putative PBP binding loops; other site 405955002867 ABC-ATPase subunit interface; other site 405955002868 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 405955002869 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 405955002870 active site 405955002871 dimer interface [polypeptide binding]; other site 405955002872 non-prolyl cis peptide bond; other site 405955002873 insertion regions; other site 405955002874 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955002875 substrate binding pocket [chemical binding]; other site 405955002876 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 405955002877 membrane-bound complex binding site; other site 405955002878 hinge residues; other site 405955002879 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 405955002880 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405955002881 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 405955002882 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 405955002883 quinone interaction residues [chemical binding]; other site 405955002884 active site 405955002885 catalytic residues [active] 405955002886 FMN binding site [chemical binding]; other site 405955002887 substrate binding site [chemical binding]; other site 405955002888 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 405955002889 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 405955002890 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 405955002891 MOSC domain; Region: MOSC; pfam03473 405955002892 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405955002893 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 405955002894 catalytic loop [active] 405955002895 iron binding site [ion binding]; other site 405955002896 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 405955002897 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 405955002898 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 405955002899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955002900 S-adenosylmethionine binding site [chemical binding]; other site 405955002901 ABC transporter ATPase component; Reviewed; Region: PRK11147 405955002902 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955002903 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955002904 Walker A/P-loop; other site 405955002905 Walker A/P-loop; other site 405955002906 ATP binding site [chemical binding]; other site 405955002907 ATP binding site [chemical binding]; other site 405955002908 Q-loop/lid; other site 405955002909 Q-loop/lid; other site 405955002910 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405955002911 ABC transporter signature motif; other site 405955002912 Walker B; other site 405955002913 D-loop; other site 405955002914 ABC transporter; Region: ABC_tran_2; pfam12848 405955002915 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405955002916 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 405955002917 Paraquat-inducible protein A; Region: PqiA; pfam04403 405955002918 Paraquat-inducible protein A; Region: PqiA; pfam04403 405955002919 paraquat-inducible protein B; Provisional; Region: PRK10807 405955002920 mce related protein; Region: MCE; pfam02470 405955002921 mce related protein; Region: MCE; pfam02470 405955002922 mce related protein; Region: MCE; pfam02470 405955002923 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 405955002924 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 405955002925 Protein of unknown function (DUF330); Region: DUF330; pfam03886 405955002926 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 405955002927 active site 1 [active] 405955002928 dimer interface [polypeptide binding]; other site 405955002929 active site 2 [active] 405955002930 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 405955002931 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 405955002932 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 405955002933 outer membrane protein A; Reviewed; Region: PRK10808 405955002934 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 405955002935 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405955002936 ligand binding site [chemical binding]; other site 405955002937 cell division inhibitor SulA; Region: sula; TIGR00623 405955002938 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 405955002939 TfoX C-terminal domain; Region: TfoX_C; pfam04994 405955002940 TIGR01666 family membrane protein; Region: YCCS 405955002941 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 405955002942 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 405955002943 Predicted membrane protein [Function unknown]; Region: COG3304 405955002944 Domain of unknown function (DUF307); Region: DUF307; pfam03733 405955002945 Domain of unknown function (DUF307); Region: DUF307; pfam03733 405955002946 DNA helicase IV; Provisional; Region: helD; PRK11054 405955002947 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 405955002948 Part of AAA domain; Region: AAA_19; pfam13245 405955002949 Family description; Region: UvrD_C_2; pfam13538 405955002950 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 405955002951 active site 405955002952 dimer interfaces [polypeptide binding]; other site 405955002953 catalytic residues [active] 405955002954 hypothetical protein; Provisional; Region: PRK03641 405955002955 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 405955002956 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 405955002957 heat shock protein HspQ; Provisional; Region: PRK14129 405955002958 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 405955002959 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 405955002960 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 405955002961 putative RNA binding site [nucleotide binding]; other site 405955002962 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955002963 S-adenosylmethionine binding site [chemical binding]; other site 405955002964 acylphosphatase; Provisional; Region: PRK14439 405955002965 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 405955002966 sulfur transfer protein TusE; Provisional; Region: PRK11508 405955002967 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 405955002968 YccA-like proteins; Region: YccA_like; cd10433 405955002969 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 405955002970 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 405955002971 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 405955002972 hydrogenase 1 large subunit; Provisional; Region: PRK10170 405955002973 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 405955002974 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 405955002975 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 405955002976 putative substrate-binding site; other site 405955002977 nickel binding site [ion binding]; other site 405955002978 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 405955002979 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 405955002980 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 405955002981 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 405955002982 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 405955002983 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 405955002984 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 405955002985 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 405955002986 catalytic core [active] 405955002987 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 405955002988 4Fe-4S binding domain; Region: Fer4_5; pfam12801 405955002989 4Fe-4S binding domain; Region: Fer4_5; pfam12801 405955002990 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405955002991 4Fe-4S dicluster domain; Region: Fer4_10; pfam13237 405955002992 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 405955002993 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 405955002994 dimerization interface [polypeptide binding]; other site 405955002995 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955002996 dimer interface [polypeptide binding]; other site 405955002997 phosphorylation site [posttranslational modification] 405955002998 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955002999 ATP binding site [chemical binding]; other site 405955003000 Mg2+ binding site [ion binding]; other site 405955003001 G-X-G motif; other site 405955003002 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955003003 active site 405955003004 phosphorylation site [posttranslational modification] 405955003005 intermolecular recognition site; other site 405955003006 dimerization interface [polypeptide binding]; other site 405955003007 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 405955003008 putative binding surface; other site 405955003009 active site 405955003010 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 405955003011 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 405955003012 putative ligand binding site [chemical binding]; other site 405955003013 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 405955003014 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955003015 active site 405955003016 phosphorylation site [posttranslational modification] 405955003017 intermolecular recognition site; other site 405955003018 dimerization interface [polypeptide binding]; other site 405955003019 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955003020 DNA binding site [nucleotide binding] 405955003021 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 405955003022 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 405955003023 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 405955003024 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 405955003025 molybdopterin cofactor binding site [chemical binding]; other site 405955003026 substrate binding site [chemical binding]; other site 405955003027 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 405955003028 molybdopterin cofactor binding site; other site 405955003029 chaperone protein TorD; Validated; Region: torD; PRK04976 405955003030 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 405955003031 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 405955003032 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 405955003033 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 405955003034 HSP70 interaction site [polypeptide binding]; other site 405955003035 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 405955003036 substrate binding site [polypeptide binding]; other site 405955003037 dimer interface [polypeptide binding]; other site 405955003038 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 405955003039 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 405955003040 catalytic core [active] 405955003041 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 405955003042 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 405955003043 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405955003044 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 405955003045 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 405955003046 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 405955003047 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 405955003048 putative FMN binding site [chemical binding]; other site 405955003049 pyrimidine utilization protein D; Region: RutD; TIGR03611 405955003050 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 405955003051 homotrimer interaction site [polypeptide binding]; other site 405955003052 putative active site [active] 405955003053 Isochorismatase family; Region: Isochorismatase; pfam00857 405955003054 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 405955003055 catalytic triad [active] 405955003056 conserved cis-peptide bond; other site 405955003057 pyrimidine utilization protein A; Region: RutA; TIGR03612 405955003058 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 405955003059 active site 405955003060 dimer interface [polypeptide binding]; other site 405955003061 non-prolyl cis peptide bond; other site 405955003062 insertion regions; other site 405955003063 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 405955003064 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 405955003065 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955003066 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 405955003067 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 405955003068 Predicted transcriptional regulator [Transcription]; Region: COG3905 405955003069 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 405955003070 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 405955003071 Glutamate binding site [chemical binding]; other site 405955003072 NAD binding site [chemical binding]; other site 405955003073 catalytic residues [active] 405955003074 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 405955003075 Na binding site [ion binding]; other site 405955003076 FTR1 family protein; Region: TIGR00145 405955003077 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 405955003078 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 405955003079 Imelysin; Region: Peptidase_M75; pfam09375 405955003080 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 405955003081 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 405955003082 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 405955003083 hypothetical protein; Provisional; Region: PRK10536 405955003084 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 405955003085 N-glycosyltransferase; Provisional; Region: PRK11204 405955003086 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 405955003087 DXD motif; other site 405955003088 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 405955003089 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 405955003090 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 405955003091 putative active site [active] 405955003092 putative metal binding site [ion binding]; other site 405955003093 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 405955003094 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405955003095 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955003096 metal binding site [ion binding]; metal-binding site 405955003097 active site 405955003098 I-site; other site 405955003099 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 405955003100 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 405955003101 putative ligand binding site [chemical binding]; other site 405955003102 NAD binding site [chemical binding]; other site 405955003103 dimerization interface [polypeptide binding]; other site 405955003104 catalytic site [active] 405955003105 putative hydrolase; Validated; Region: PRK09248 405955003106 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 405955003107 active site 405955003108 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 405955003109 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 405955003110 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 405955003111 curli assembly protein CsgF; Provisional; Region: PRK10050 405955003112 curli assembly protein CsgE; Provisional; Region: PRK10386 405955003113 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 405955003114 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955003115 DNA binding residues [nucleotide binding] 405955003116 dimerization interface [polypeptide binding]; other site 405955003117 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 405955003118 Curlin associated repeat; Region: Curlin_rpt; pfam07012 405955003119 Curlin associated repeat; Region: Curlin_rpt; pfam07012 405955003120 major curlin subunit; Provisional; Region: csgA; PRK10051 405955003121 Curlin associated repeat; Region: Curlin_rpt; pfam07012 405955003122 Curlin associated repeat; Region: Curlin_rpt; pfam07012 405955003123 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 405955003124 Fimbrial protein; Region: Fimbrial; cl01416 405955003125 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 405955003126 putative ADP-ribose binding site [chemical binding]; other site 405955003127 putative active site [active] 405955003128 Phosphatidylserine/phosphatidylglycerophosphate/car diolipin synthases and related enzymes [Lipid metabolism]; Region: Cls; COG1502 405955003129 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 405955003130 putative active site [active] 405955003131 catalytic site [active] 405955003132 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 405955003133 putative active site [active] 405955003134 catalytic site [active] 405955003135 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 405955003136 Acyltransferase family; Region: Acyl_transf_3; pfam01757 405955003137 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 405955003138 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 405955003139 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 405955003140 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 405955003141 Ligand binding site; other site 405955003142 DXD motif; other site 405955003143 secY/secA suppressor protein; Provisional; Region: PRK11467 405955003144 drug efflux system protein MdtG; Provisional; Region: PRK09874 405955003145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955003146 putative substrate translocation pore; other site 405955003147 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 405955003148 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 405955003149 putative acyl-acceptor binding pocket; other site 405955003150 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 405955003151 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 405955003152 active site residue [active] 405955003153 hypothetical protein; Provisional; Region: PRK03757 405955003154 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 405955003155 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 405955003156 hydroxyglutarate oxidase; Provisional; Region: PRK11728 405955003157 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 405955003158 DNA damage-inducible protein I; Provisional; Region: PRK10597 405955003159 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 405955003160 active site 405955003161 substrate binding pocket [chemical binding]; other site 405955003162 dimer interface [polypeptide binding]; other site 405955003163 lipoprotein; Provisional; Region: PRK10598 405955003164 glutaredoxin 2; Provisional; Region: PRK10387 405955003165 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 405955003166 C-terminal domain interface [polypeptide binding]; other site 405955003167 GSH binding site (G-site) [chemical binding]; other site 405955003168 catalytic residues [active] 405955003169 putative dimer interface [polypeptide binding]; other site 405955003170 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 405955003171 N-terminal domain interface [polypeptide binding]; other site 405955003172 multidrug resistance protein MdtH; Provisional; Region: PRK11646 405955003173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955003174 putative substrate translocation pore; other site 405955003175 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 405955003176 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405955003177 hypothetical protein; Provisional; Region: PRK11239 405955003178 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 405955003179 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 405955003180 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405955003181 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405955003182 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 405955003183 MviN-like protein; Region: MVIN; pfam03023 405955003184 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 405955003185 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 405955003186 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 405955003187 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 405955003188 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 405955003189 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 405955003190 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 405955003191 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 405955003192 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 405955003193 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 405955003194 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 405955003195 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 405955003196 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 405955003197 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 405955003198 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 405955003199 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 405955003200 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 405955003201 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 405955003202 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 405955003203 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 405955003204 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 405955003205 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 405955003206 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 405955003207 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 405955003208 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 405955003209 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 405955003210 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 405955003211 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 405955003212 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 405955003213 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 405955003214 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 405955003215 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 405955003216 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 405955003217 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 405955003218 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 405955003219 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 405955003220 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 405955003221 homodimer interface [polypeptide binding]; other site 405955003222 oligonucleotide binding site [chemical binding]; other site 405955003223 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 405955003224 Protein of unknown function (DUF2655); Region: DUF2655; pfam10848 405955003225 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 405955003226 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405955003227 RNA binding surface [nucleotide binding]; other site 405955003228 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405955003229 active site 405955003230 Maf-like protein; Region: Maf; pfam02545 405955003231 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 405955003232 active site 405955003233 dimer interface [polypeptide binding]; other site 405955003234 hypothetical protein; Provisional; Region: PRK11193 405955003235 putative phosphate acyltransferase; Provisional; Region: PRK05331 405955003236 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 405955003237 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 405955003238 dimer interface [polypeptide binding]; other site 405955003239 active site 405955003240 CoA binding pocket [chemical binding]; other site 405955003241 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 405955003242 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 405955003243 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 405955003244 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 405955003245 NAD(P) binding site [chemical binding]; other site 405955003246 homotetramer interface [polypeptide binding]; other site 405955003247 homodimer interface [polypeptide binding]; other site 405955003248 active site 405955003249 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 405955003250 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 405955003251 dimer interface [polypeptide binding]; other site 405955003252 active site 405955003253 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405955003254 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 405955003255 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955003256 catalytic residue [active] 405955003257 conserved hypothetical protein, YceG family; Region: TIGR00247 405955003258 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 405955003259 dimerization interface [polypeptide binding]; other site 405955003260 thymidylate kinase; Validated; Region: tmk; PRK00698 405955003261 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 405955003262 TMP-binding site; other site 405955003263 ATP-binding site [chemical binding]; other site 405955003264 DNA polymerase III subunit delta'; Validated; Region: PRK07993 405955003265 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 405955003266 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 405955003267 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 405955003268 active site 405955003269 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 405955003270 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405955003271 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405955003272 active site turn [active] 405955003273 phosphorylation site [posttranslational modification] 405955003274 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 405955003275 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 405955003276 N-terminal plug; other site 405955003277 ligand-binding site [chemical binding]; other site 405955003278 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 405955003279 nucleotide binding site/active site [active] 405955003280 HIT family signature motif; other site 405955003281 catalytic residue [active] 405955003282 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 405955003283 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 405955003284 putative dimer interface [polypeptide binding]; other site 405955003285 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 405955003286 thiamine kinase; Region: ycfN_thiK; TIGR02721 405955003287 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 405955003288 active site 405955003289 substrate binding site [chemical binding]; other site 405955003290 ATP binding site [chemical binding]; other site 405955003291 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 405955003292 beta-hexosaminidase; Provisional; Region: PRK05337 405955003293 hypothetical protein; Provisional; Region: PRK04940 405955003294 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 405955003295 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955003296 hypothetical protein; Provisional; Region: PRK11280 405955003297 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405955003298 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955003299 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 405955003300 L,D-transpeptidase; Provisional; Region: PRK10260 405955003301 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405955003302 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405955003303 transcription-repair coupling factor; Provisional; Region: PRK10689 405955003304 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 405955003305 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405955003306 ATP binding site [chemical binding]; other site 405955003307 putative Mg++ binding site [ion binding]; other site 405955003308 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405955003309 nucleotide binding region [chemical binding]; other site 405955003310 ATP-binding site [chemical binding]; other site 405955003311 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 405955003312 Predicted membrane protein [Function unknown]; Region: COG4763 405955003313 Acyltransferase family; Region: Acyl_transf_3; pfam01757 405955003314 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 405955003315 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405955003316 FtsX-like permease family; Region: FtsX; pfam02687 405955003317 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 405955003318 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405955003319 Walker A/P-loop; other site 405955003320 ATP binding site [chemical binding]; other site 405955003321 Q-loop/lid; other site 405955003322 ABC transporter signature motif; other site 405955003323 Walker B; other site 405955003324 D-loop; other site 405955003325 H-loop/switch region; other site 405955003326 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 405955003327 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405955003328 FtsX-like permease family; Region: FtsX; pfam02687 405955003329 fructokinase; Reviewed; Region: PRK09557 405955003330 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405955003331 nucleotide binding site [chemical binding]; other site 405955003332 NAD-dependent deacetylase; Provisional; Region: PRK00481 405955003333 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 405955003334 NAD+ binding site [chemical binding]; other site 405955003335 substrate binding site [chemical binding]; other site 405955003336 Zn binding site [ion binding]; other site 405955003337 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 405955003338 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 405955003339 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 405955003340 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 405955003341 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955003342 dimer interface [polypeptide binding]; other site 405955003343 conserved gate region; other site 405955003344 putative PBP binding loops; other site 405955003345 ABC-ATPase subunit interface; other site 405955003346 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 405955003347 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955003348 dimer interface [polypeptide binding]; other site 405955003349 conserved gate region; other site 405955003350 putative PBP binding loops; other site 405955003351 ABC-ATPase subunit interface; other site 405955003352 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 405955003353 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955003354 Walker A/P-loop; other site 405955003355 ATP binding site [chemical binding]; other site 405955003356 Q-loop/lid; other site 405955003357 ABC transporter signature motif; other site 405955003358 Walker B; other site 405955003359 D-loop; other site 405955003360 H-loop/switch region; other site 405955003361 TOBE domain; Region: TOBE_2; pfam08402 405955003362 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 405955003363 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 405955003364 metal binding site [ion binding]; metal-binding site 405955003365 dimer interface [polypeptide binding]; other site 405955003366 Uncharacterized conserved protein [Function unknown]; Region: COG2850 405955003367 Cupin-like domain; Region: Cupin_8; pfam13621 405955003368 sensor protein PhoQ; Provisional; Region: PRK10815 405955003369 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 405955003370 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 405955003371 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 405955003372 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955003373 ATP binding site [chemical binding]; other site 405955003374 Mg2+ binding site [ion binding]; other site 405955003375 G-X-G motif; other site 405955003376 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 405955003377 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955003378 active site 405955003379 phosphorylation site [posttranslational modification] 405955003380 intermolecular recognition site; other site 405955003381 dimerization interface [polypeptide binding]; other site 405955003382 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955003383 DNA binding site [nucleotide binding] 405955003384 adenylosuccinate lyase; Provisional; Region: PRK09285 405955003385 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 405955003386 tetramer interface [polypeptide binding]; other site 405955003387 active site 405955003388 putative lysogenization regulator; Reviewed; Region: PRK00218 405955003389 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 405955003390 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 405955003391 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 405955003392 nudix motif; other site 405955003393 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 405955003394 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 405955003395 probable active site [active] 405955003396 isocitrate dehydrogenase; Validated; Region: PRK07362 405955003397 isocitrate dehydrogenase; Reviewed; Region: PRK07006 405955003398 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 405955003399 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 405955003400 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 405955003401 dimer interface [polypeptide binding]; other site 405955003402 active site 405955003403 Int/Topo IB signature motif; other site 405955003404 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 405955003405 phage recombination protein Bet; Region: bet_lambda; TIGR01913 405955003406 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 405955003407 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 405955003408 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 405955003409 Superinfection exclusion protein B; Region: SieB; pfam14163 405955003410 Domain of unknown function DUF1828; Region: DUF1828; pfam08861 405955003411 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 405955003412 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955003413 non-specific DNA binding site [nucleotide binding]; other site 405955003414 salt bridge; other site 405955003415 sequence-specific DNA binding site [nucleotide binding]; other site 405955003416 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 405955003417 Catalytic site [active] 405955003418 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405955003419 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955003420 non-specific DNA binding site [nucleotide binding]; other site 405955003421 salt bridge; other site 405955003422 sequence-specific DNA binding site [nucleotide binding]; other site 405955003423 Bacteriophage CII protein; Region: Phage_CII; pfam05269 405955003424 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 405955003425 Replication protein P; Region: Phage_lambda_P; pfam06992 405955003426 NinB protein; Region: NinB; pfam05772 405955003427 phage N-6-adenine-methyltransferase; Region: phage_N6A_met; TIGR01712 405955003428 hypothetical protein; Region: PHA01519 405955003429 endodeoxyribonuclease RUS; Reviewed; Region: PRK09786 405955003430 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 405955003431 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 405955003432 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 405955003433 trimer interface [polypeptide binding]; other site 405955003434 eyelet of channel; other site 405955003435 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 405955003436 catalytic residues [active] 405955003437 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 405955003438 Bor protein; Region: Lambda_Bor; pfam06291 405955003439 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 405955003440 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 405955003441 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 405955003442 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 405955003443 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 405955003444 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 405955003445 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 405955003446 tandem repeat interface [polypeptide binding]; other site 405955003447 oligomer interface [polypeptide binding]; other site 405955003448 active site residues [active] 405955003449 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 405955003450 DNA packaging protein FI; Region: Packaging_FI; pfam14000 405955003451 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 405955003452 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 405955003453 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 405955003454 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 405955003455 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 405955003456 phage minor tail protein G; Region: phage_lambda_G; TIGR01674 405955003457 Minor tail protein T; Region: Phage_tail_T; cl05636 405955003458 Phage-related minor tail protein [Function unknown]; Region: COG5281 405955003459 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 405955003460 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 405955003461 Phage-related protein [Function unknown]; Region: COG4718 405955003462 Phage-related protein [Function unknown]; Region: gp18; COG4672 405955003463 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 405955003464 MPN+ (JAMM) motif; other site 405955003465 Zinc-binding site [ion binding]; other site 405955003466 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405955003467 NlpC/P60 family; Region: NLPC_P60; cl17555 405955003468 Phage-related protein, tail component [Function unknown]; Region: COG4723 405955003469 Phage-related protein, tail component [Function unknown]; Region: COG4733 405955003470 Putative phage tail protein; Region: Phage-tail_3; pfam13550 405955003471 Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all...; Region: FN3; cd00063 405955003472 Interdomain contacts; other site 405955003473 Cytokine receptor motif; other site 405955003474 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 405955003475 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 405955003476 Fibronectin type III protein; Region: DUF3672; pfam12421 405955003477 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 405955003478 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 405955003479 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 405955003480 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955003481 ABC-ATPase subunit interface; other site 405955003482 dimer interface [polypeptide binding]; other site 405955003483 putative PBP binding regions; other site 405955003484 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 405955003485 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955003486 ABC-ATPase subunit interface; other site 405955003487 dimer interface [polypeptide binding]; other site 405955003488 putative PBP binding regions; other site 405955003489 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 405955003490 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 405955003491 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 405955003492 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 405955003493 metal binding site [ion binding]; metal-binding site 405955003494 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 405955003495 transcriptional regulator MirA; Provisional; Region: PRK15043 405955003496 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 405955003497 DNA binding residues [nucleotide binding] 405955003498 Sensors of blue-light using FAD; Region: BLUF; smart01034 405955003499 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955003500 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 405955003501 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955003502 Autotransporter beta-domain; Region: Autotransporter; cl17461 405955003503 Autotransporter beta-domain; Region: Autotransporter; smart00869 405955003504 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 405955003505 cell division inhibitor MinD; Provisional; Region: PRK10818 405955003506 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 405955003507 Switch I; other site 405955003508 Switch II; other site 405955003509 septum formation inhibitor; Reviewed; Region: minC; PRK03511 405955003510 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 405955003511 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 405955003512 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 405955003513 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 405955003514 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 405955003515 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 405955003516 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 405955003517 hypothetical protein; Provisional; Region: PRK10691 405955003518 hypothetical protein; Provisional; Region: PRK05170 405955003519 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 405955003520 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 405955003521 Catalytic site [active] 405955003522 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 405955003523 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 405955003524 active site 405955003525 DNA binding site [nucleotide binding] 405955003526 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 405955003527 disulfide bond formation protein B; Provisional; Region: PRK01749 405955003528 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 405955003529 transmembrane helices; other site 405955003530 fatty acid metabolism regulator; Provisional; Region: PRK04984 405955003531 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955003532 DNA-binding site [nucleotide binding]; DNA binding site 405955003533 FadR C-terminal domain; Region: FadR_C; pfam07840 405955003534 SpoVR family protein; Provisional; Region: PRK11767 405955003535 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 405955003536 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 405955003537 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955003538 alanine racemase; Reviewed; Region: dadX; PRK03646 405955003539 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 405955003540 active site 405955003541 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405955003542 substrate binding site [chemical binding]; other site 405955003543 catalytic residues [active] 405955003544 dimer interface [polypeptide binding]; other site 405955003545 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 405955003546 TrkA-C domain; Region: TrkA_C; pfam02080 405955003547 Transporter associated domain; Region: CorC_HlyC; smart01091 405955003548 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 405955003549 dimer interface [polypeptide binding]; other site 405955003550 catalytic triad [active] 405955003551 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 405955003552 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405955003553 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405955003554 catalytic residue [active] 405955003555 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 405955003556 Flagellar regulator YcgR; Region: YcgR; pfam07317 405955003557 PilZ domain; Region: PilZ; pfam07238 405955003558 hypothetical protein; Provisional; Region: PRK10457 405955003559 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 405955003560 N-terminal plug; other site 405955003561 TonB-dependent hemoglobin/transferrin/lactoferrin receptor family protein; Region: TonB-hemlactrns; TIGR01786 405955003562 ligand-binding site [chemical binding]; other site 405955003563 molybdenum transport protein ModD; Provisional; Region: PRK06096 405955003564 ModD; Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase) present in some modABC operons in bacteria, which are involved in molybdate transport. In general, QPRTases are part of the de novo synthesis pathway of NAD in both prokaryotes and...; Region: modD_like; cd01573 405955003565 dimerization interface [polypeptide binding]; other site 405955003566 active site 405955003567 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405955003568 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955003569 S-adenosylmethionine binding site [chemical binding]; other site 405955003570 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405955003571 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405955003572 Walker A/P-loop; other site 405955003573 ATP binding site [chemical binding]; other site 405955003574 Q-loop/lid; other site 405955003575 ABC transporter signature motif; other site 405955003576 Walker B; other site 405955003577 D-loop; other site 405955003578 H-loop/switch region; other site 405955003579 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405955003580 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955003581 ABC-ATPase subunit interface; other site 405955003582 dimer interface [polypeptide binding]; other site 405955003583 putative PBP binding regions; other site 405955003584 ABC-type Fe3+-hydroxamate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: FepB; COG0614 405955003585 Metal binding protein HemV-2. These proteins are predicted to function as initial receptors in ABC transport of metal ions. They belong to the TroA superfamily of helical backbone metal receptor proteins that share a distinct fold and ligand binding...; Region: HemV-2; cd01147 405955003586 putative metal binding site [ion binding]; other site 405955003587 trehalase; Provisional; Region: treA; PRK13271 405955003588 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 405955003589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 405955003590 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 405955003591 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405955003592 dimerization domain swap beta strand [polypeptide binding]; other site 405955003593 regulatory protein interface [polypeptide binding]; other site 405955003594 active site 405955003595 regulatory phosphorylation site [posttranslational modification]; other site 405955003596 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 405955003597 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405955003598 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 405955003599 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 405955003600 Dak1 domain; Region: Dak1; pfam02733 405955003601 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 405955003602 PAS domain; Region: PAS; smart00091 405955003603 putative active site [active] 405955003604 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955003605 Walker A motif; other site 405955003606 ATP binding site [chemical binding]; other site 405955003607 Walker B motif; other site 405955003608 arginine finger; other site 405955003609 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405955003610 GTP-binding protein YchF; Reviewed; Region: PRK09601 405955003611 YchF GTPase; Region: YchF; cd01900 405955003612 G1 box; other site 405955003613 GTP/Mg2+ binding site [chemical binding]; other site 405955003614 Switch I region; other site 405955003615 G2 box; other site 405955003616 Switch II region; other site 405955003617 G3 box; other site 405955003618 G4 box; other site 405955003619 G5 box; other site 405955003620 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 405955003621 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 405955003622 putative active site [active] 405955003623 hypothetical protein; Provisional; Region: PRK10692 405955003624 putative transporter; Provisional; Region: PRK11660 405955003625 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 405955003626 Sulfate transporter family; Region: Sulfate_transp; pfam00916 405955003627 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 405955003628 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 405955003629 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 405955003630 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405955003631 active site 405955003632 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 405955003633 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 405955003634 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 405955003635 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 405955003636 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 405955003637 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 405955003638 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 405955003639 tRNA; other site 405955003640 putative tRNA binding site [nucleotide binding]; other site 405955003641 putative NADP binding site [chemical binding]; other site 405955003642 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 405955003643 peptide chain release factor 1; Validated; Region: prfA; PRK00591 405955003644 This domain is found in peptide chain release factors; Region: PCRF; smart00937 405955003645 RF-1 domain; Region: RF-1; pfam00472 405955003646 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 405955003647 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955003648 hypothetical protein; Provisional; Region: PRK10278 405955003649 hypothetical protein; Provisional; Region: PRK10941 405955003650 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 405955003651 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 405955003652 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 405955003653 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 405955003654 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 405955003655 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 405955003656 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 405955003657 putative active site pocket [active] 405955003658 dimerization interface [polypeptide binding]; other site 405955003659 putative catalytic residue [active] 405955003660 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 405955003661 putative invasin; Provisional; Region: PRK10177 405955003662 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 405955003663 transcriptional regulator NarL; Provisional; Region: PRK10651 405955003664 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955003665 active site 405955003666 phosphorylation site [posttranslational modification] 405955003667 intermolecular recognition site; other site 405955003668 dimerization interface [polypeptide binding]; other site 405955003669 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955003670 DNA binding residues [nucleotide binding] 405955003671 dimerization interface [polypeptide binding]; other site 405955003672 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 405955003673 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 405955003674 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405955003675 dimerization interface [polypeptide binding]; other site 405955003676 Histidine kinase; Region: HisKA_3; pfam07730 405955003677 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955003678 ATP binding site [chemical binding]; other site 405955003679 Mg2+ binding site [ion binding]; other site 405955003680 G-X-G motif; other site 405955003681 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 405955003682 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 405955003683 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 405955003684 [4Fe-4S] binding site [ion binding]; other site 405955003685 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405955003686 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405955003687 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405955003688 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 405955003689 molybdopterin cofactor binding site; other site 405955003690 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 405955003691 4Fe-4S binding domain; Region: Fer4; cl02805 405955003692 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 405955003693 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 405955003694 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405955003695 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 405955003696 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 405955003697 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 405955003698 putative active site [active] 405955003699 putative substrate binding site [chemical binding]; other site 405955003700 putative cosubstrate binding site; other site 405955003701 catalytic site [active] 405955003702 SEC-C motif; Region: SEC-C; pfam02810 405955003703 hypothetical protein; Provisional; Region: PRK04233 405955003704 hypothetical protein; Provisional; Region: PRK10279 405955003705 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 405955003706 active site 405955003707 nucleophile elbow; other site 405955003708 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955003709 active site 405955003710 response regulator of RpoS; Provisional; Region: PRK10693 405955003711 phosphorylation site [posttranslational modification] 405955003712 intermolecular recognition site; other site 405955003713 dimerization interface [polypeptide binding]; other site 405955003714 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 405955003715 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 405955003716 active site 405955003717 tetramer interface; other site 405955003718 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 405955003719 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 405955003720 thymidine kinase; Provisional; Region: PRK04296 405955003721 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 405955003722 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 405955003723 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405955003724 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 405955003725 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 405955003726 putative catalytic cysteine [active] 405955003727 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 405955003728 putative active site [active] 405955003729 metal binding site [ion binding]; metal-binding site 405955003730 hypothetical protein; Provisional; Region: PRK11111 405955003731 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 405955003732 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405955003733 peptide binding site [polypeptide binding]; other site 405955003734 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 405955003735 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955003736 dimer interface [polypeptide binding]; other site 405955003737 conserved gate region; other site 405955003738 putative PBP binding loops; other site 405955003739 ABC-ATPase subunit interface; other site 405955003740 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 405955003741 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405955003742 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955003743 dimer interface [polypeptide binding]; other site 405955003744 conserved gate region; other site 405955003745 putative PBP binding loops; other site 405955003746 ABC-ATPase subunit interface; other site 405955003747 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 405955003748 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955003749 Walker A/P-loop; other site 405955003750 ATP binding site [chemical binding]; other site 405955003751 Q-loop/lid; other site 405955003752 ABC transporter signature motif; other site 405955003753 Walker B; other site 405955003754 D-loop; other site 405955003755 H-loop/switch region; other site 405955003756 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405955003757 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 405955003758 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955003759 Walker A/P-loop; other site 405955003760 ATP binding site [chemical binding]; other site 405955003761 Q-loop/lid; other site 405955003762 ABC transporter signature motif; other site 405955003763 Walker B; other site 405955003764 D-loop; other site 405955003765 H-loop/switch region; other site 405955003766 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405955003767 dsDNA-mimic protein; Reviewed; Region: PRK05094 405955003768 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 405955003769 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 405955003770 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 405955003771 putative active site [active] 405955003772 catalytic site [active] 405955003773 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 405955003774 putative active site [active] 405955003775 catalytic site [active] 405955003776 voltage-gated potassium channel; Provisional; Region: PRK10537 405955003777 Ion channel; Region: Ion_trans_2; pfam07885 405955003778 TrkA-N domain; Region: TrkA_N; pfam02254 405955003779 YciI-like protein; Reviewed; Region: PRK11370 405955003780 transport protein TonB; Provisional; Region: PRK10819 405955003781 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 405955003782 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 405955003783 intracellular septation protein A; Reviewed; Region: PRK00259 405955003784 hypothetical protein; Provisional; Region: PRK02868 405955003785 outer membrane protein W; Provisional; Region: PRK10959 405955003786 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 405955003787 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 405955003788 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 405955003789 dimer interface [polypeptide binding]; other site 405955003790 active site 405955003791 Int/Topo IB signature motif; other site 405955003792 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 405955003793 active site 405955003794 catalytic site [active] 405955003795 substrate binding site [chemical binding]; other site 405955003796 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955003797 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 405955003798 non-specific DNA binding site [nucleotide binding]; other site 405955003799 salt bridge; other site 405955003800 sequence-specific DNA binding site [nucleotide binding]; other site 405955003801 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 405955003802 Catalytic site [active] 405955003803 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 405955003804 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 405955003805 primosomal protein DnaI; Provisional; Region: PRK02854 405955003806 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 405955003807 Protein of unknown function (DUF968); Region: DUF968; pfam06147 405955003808 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 405955003809 Antitermination protein; Region: Antiterm; pfam03589 405955003810 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 405955003811 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955003812 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 405955003813 DNA methylase; Region: N6_N4_Mtase; pfam01555 405955003814 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 405955003815 Lysis protein S; Region: Lysis_S; pfam04971 405955003816 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 405955003817 Fatty acid cis/trans isomerase (CTI); Region: CTI; pfam06934 405955003818 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 405955003819 catalytic residues [active] 405955003820 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 405955003821 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 405955003822 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 405955003823 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 405955003824 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 405955003825 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 405955003826 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 405955003827 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 405955003828 tandem repeat interface [polypeptide binding]; other site 405955003829 oligomer interface [polypeptide binding]; other site 405955003830 active site residues [active] 405955003831 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 405955003832 DNA packaging protein FI; Region: Packaging_FI; pfam14000 405955003833 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 405955003834 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 405955003835 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 405955003836 Phage-related minor tail protein [Function unknown]; Region: COG5281 405955003837 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 405955003838 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 405955003839 Phage-related protein [Function unknown]; Region: COG4718 405955003840 Phage-related protein [Function unknown]; Region: gp18; COG4672 405955003841 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 405955003842 MPN+ (JAMM) motif; other site 405955003843 Zinc-binding site [ion binding]; other site 405955003844 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405955003845 NlpC/P60 family; Region: NLPC_P60; cl17555 405955003846 Phage-related protein, tail component [Function unknown]; Region: COG4723 405955003847 Phage-related protein, tail component [Function unknown]; Region: COG4733 405955003848 Putative phage tail protein; Region: Phage-tail_3; pfam13550 405955003849 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 405955003850 Fibronectin type III protein; Region: DUF3672; pfam12421 405955003851 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 405955003852 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 405955003853 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 405955003854 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 405955003855 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 405955003856 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 405955003857 Phage Tail Collar Domain; Region: Collar; pfam07484 405955003858 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 405955003859 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 405955003860 Methyltransferase domain; Region: Methyltransf_31; pfam13847 405955003861 Methyltransferase domain; Region: Methyltransf_12; pfam08242 405955003862 S-adenosylmethionine binding site [chemical binding]; other site 405955003863 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 405955003864 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 405955003865 dimerization interface [polypeptide binding]; other site 405955003866 metal binding site [ion binding]; metal-binding site 405955003867 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 405955003868 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 405955003869 substrate binding site [chemical binding]; other site 405955003870 active site 405955003871 catalytic residues [active] 405955003872 heterodimer interface [polypeptide binding]; other site 405955003873 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 405955003874 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 405955003875 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955003876 catalytic residue [active] 405955003877 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 405955003878 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 405955003879 active site 405955003880 ribulose/triose binding site [chemical binding]; other site 405955003881 phosphate binding site [ion binding]; other site 405955003882 substrate (anthranilate) binding pocket [chemical binding]; other site 405955003883 product (indole) binding pocket [chemical binding]; other site 405955003884 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 405955003885 active site 405955003886 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 405955003887 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 405955003888 glutamine binding [chemical binding]; other site 405955003889 catalytic triad [active] 405955003890 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405955003891 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 405955003892 anthranilate synthase component I; Provisional; Region: PRK13564 405955003893 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 405955003894 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405955003895 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 405955003896 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 405955003897 active site 405955003898 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 405955003899 hypothetical protein; Provisional; Region: PRK11630 405955003900 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 405955003901 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 405955003902 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405955003903 RNA binding surface [nucleotide binding]; other site 405955003904 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 405955003905 probable active site [active] 405955003906 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 405955003907 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 405955003908 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 405955003909 homodimer interface [polypeptide binding]; other site 405955003910 Walker A motif; other site 405955003911 ATP binding site [chemical binding]; other site 405955003912 hydroxycobalamin binding site [chemical binding]; other site 405955003913 Walker B motif; other site 405955003914 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 405955003915 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 405955003916 NADP binding site [chemical binding]; other site 405955003917 homodimer interface [polypeptide binding]; other site 405955003918 active site 405955003919 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 405955003920 putative inner membrane peptidase; Provisional; Region: PRK11778 405955003921 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 405955003922 tandem repeat interface [polypeptide binding]; other site 405955003923 oligomer interface [polypeptide binding]; other site 405955003924 active site residues [active] 405955003925 hypothetical protein; Provisional; Region: PRK11037 405955003926 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 405955003927 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 405955003928 active site 405955003929 interdomain interaction site; other site 405955003930 putative metal-binding site [ion binding]; other site 405955003931 nucleotide binding site [chemical binding]; other site 405955003932 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405955003933 domain I; other site 405955003934 DNA binding groove [nucleotide binding] 405955003935 phosphate binding site [ion binding]; other site 405955003936 domain II; other site 405955003937 domain III; other site 405955003938 nucleotide binding site [chemical binding]; other site 405955003939 catalytic site [active] 405955003940 domain IV; other site 405955003941 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405955003942 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405955003943 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 405955003944 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 405955003945 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 405955003946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955003947 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 405955003948 substrate binding site [chemical binding]; other site 405955003949 putative dimerization interface [polypeptide binding]; other site 405955003950 aconitate hydratase; Validated; Region: PRK09277 405955003951 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 405955003952 substrate binding site [chemical binding]; other site 405955003953 ligand binding site [chemical binding]; other site 405955003954 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 405955003955 substrate binding site [chemical binding]; other site 405955003956 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 405955003957 dimerization interface [polypeptide binding]; other site 405955003958 active site 405955003959 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405955003960 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 405955003961 active site 405955003962 Predicted membrane protein [Function unknown]; Region: COG3771 405955003963 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 405955003964 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405955003965 TPR motif; other site 405955003966 binding surface 405955003967 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405955003968 binding surface 405955003969 TPR motif; other site 405955003970 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 405955003971 active site 405955003972 dimer interface [polypeptide binding]; other site 405955003973 translation initiation factor Sui1; Validated; Region: PRK06824 405955003974 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 405955003975 putative rRNA binding site [nucleotide binding]; other site 405955003976 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405955003977 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 405955003978 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405955003979 RNase II stability modulator; Provisional; Region: PRK10060 405955003980 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405955003981 putative active site [active] 405955003982 heme pocket [chemical binding]; other site 405955003983 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955003984 metal binding site [ion binding]; metal-binding site 405955003985 active site 405955003986 I-site; other site 405955003987 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955003988 exoribonuclease II; Provisional; Region: PRK05054 405955003989 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 405955003990 RNB domain; Region: RNB; pfam00773 405955003991 S1 RNA binding domain; Region: S1; pfam00575 405955003992 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 405955003993 Uncharacterized conserved protein [Function unknown]; Region: COG2128 405955003994 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 405955003995 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 405955003996 NAD binding site [chemical binding]; other site 405955003997 homotetramer interface [polypeptide binding]; other site 405955003998 homodimer interface [polypeptide binding]; other site 405955003999 substrate binding site [chemical binding]; other site 405955004000 active site 405955004001 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405955004002 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955004003 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 405955004004 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955004005 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955004006 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 405955004007 Protein export membrane protein; Region: SecD_SecF; cl14618 405955004008 Outer membrane protein [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: TolC; COG1538 405955004009 drug resistance transporter, Bcr/CflA subfamily; Region: efflux_Bcr_CflA; TIGR00710 405955004010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955004011 putative substrate translocation pore; other site 405955004012 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 405955004013 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955004014 Walker A/P-loop; other site 405955004015 ATP binding site [chemical binding]; other site 405955004016 Q-loop/lid; other site 405955004017 ABC transporter signature motif; other site 405955004018 Walker B; other site 405955004019 D-loop; other site 405955004020 H-loop/switch region; other site 405955004021 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 405955004022 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955004023 Walker A/P-loop; other site 405955004024 ATP binding site [chemical binding]; other site 405955004025 Q-loop/lid; other site 405955004026 ABC transporter signature motif; other site 405955004027 Walker B; other site 405955004028 D-loop; other site 405955004029 H-loop/switch region; other site 405955004030 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405955004031 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 405955004032 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405955004033 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955004034 dimer interface [polypeptide binding]; other site 405955004035 conserved gate region; other site 405955004036 putative PBP binding loops; other site 405955004037 ABC-ATPase subunit interface; other site 405955004038 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 405955004039 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955004040 dimer interface [polypeptide binding]; other site 405955004041 conserved gate region; other site 405955004042 putative PBP binding loops; other site 405955004043 ABC-ATPase subunit interface; other site 405955004044 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405955004045 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 405955004046 peptide binding site [polypeptide binding]; other site 405955004047 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 405955004048 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955004049 Walker A motif; other site 405955004050 ATP binding site [chemical binding]; other site 405955004051 Walker B motif; other site 405955004052 arginine finger; other site 405955004053 phage shock protein PspA; Provisional; Region: PRK10698 405955004054 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 405955004055 phage shock protein C; Region: phageshock_pspC; TIGR02978 405955004056 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405955004057 active site residue [active] 405955004058 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 405955004059 sucrose phosphorylase; Provisional; Region: PRK13840 405955004060 active site 405955004061 homodimer interface [polypeptide binding]; other site 405955004062 catalytic site [active] 405955004063 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 405955004064 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 405955004065 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 405955004066 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955004067 dimer interface [polypeptide binding]; other site 405955004068 conserved gate region; other site 405955004069 putative PBP binding loops; other site 405955004070 ABC-ATPase subunit interface; other site 405955004071 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 405955004072 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955004073 dimer interface [polypeptide binding]; other site 405955004074 conserved gate region; other site 405955004075 putative PBP binding loops; other site 405955004076 ABC-ATPase subunit interface; other site 405955004077 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405955004078 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 405955004079 putative NAD(P) binding site [chemical binding]; other site 405955004080 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 405955004081 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 405955004082 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405955004083 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405955004084 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 405955004085 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 405955004086 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 405955004087 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 405955004088 beta-phosphoglucomutase; Region: bPGM; TIGR01990 405955004089 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955004090 motif II; other site 405955004091 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 405955004092 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 405955004093 Walker A/P-loop; other site 405955004094 ATP binding site [chemical binding]; other site 405955004095 Q-loop/lid; other site 405955004096 ABC transporter signature motif; other site 405955004097 Walker B; other site 405955004098 D-loop; other site 405955004099 H-loop/switch region; other site 405955004100 TOBE domain; Region: TOBE_2; pfam08402 405955004101 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 405955004102 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405955004103 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955004104 DNA binding site [nucleotide binding] 405955004105 domain linker motif; other site 405955004106 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 405955004107 putative dimerization interface [polypeptide binding]; other site 405955004108 putative ligand binding site [chemical binding]; other site 405955004109 Predicted ATPase [General function prediction only]; Region: COG3106 405955004110 hypothetical protein; Provisional; Region: PRK05415 405955004111 TIGR01620 family protein; Region: hyp_HI0043 405955004112 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 405955004113 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 405955004114 putative aromatic amino acid binding site; other site 405955004115 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955004116 Walker A motif; other site 405955004117 ATP binding site [chemical binding]; other site 405955004118 Walker B motif; other site 405955004119 arginine finger; other site 405955004120 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 405955004121 dimer interface [polypeptide binding]; other site 405955004122 catalytic triad [active] 405955004123 peroxidatic and resolving cysteines [active] 405955004124 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 405955004125 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 405955004126 active site 405955004127 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 405955004128 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 405955004129 putative active site [active] 405955004130 Zn binding site [ion binding]; other site 405955004131 atypical (a) SDRs, subgroup 6; Region: SDR_a6; cd05267 405955004132 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405955004133 putative NAD(P) binding site [chemical binding]; other site 405955004134 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 405955004135 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405955004136 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405955004137 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955004138 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 405955004139 putative effector binding pocket; other site 405955004140 putative dimerization interface [polypeptide binding]; other site 405955004141 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 405955004142 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405955004143 peptide binding site [polypeptide binding]; other site 405955004144 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 405955004145 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405955004146 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 405955004147 universal stress protein UspE; Provisional; Region: PRK11175 405955004148 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405955004149 Ligand Binding Site [chemical binding]; other site 405955004150 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405955004151 Ligand Binding Site [chemical binding]; other site 405955004152 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 405955004153 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405955004154 ligand binding site [chemical binding]; other site 405955004155 flexible hinge region; other site 405955004156 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 405955004157 putative switch regulator; other site 405955004158 non-specific DNA interactions [nucleotide binding]; other site 405955004159 DNA binding site [nucleotide binding] 405955004160 sequence specific DNA binding site [nucleotide binding]; other site 405955004161 putative cAMP binding site [chemical binding]; other site 405955004162 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 405955004163 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 405955004164 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 405955004165 DNA binding site [nucleotide binding] 405955004166 active site 405955004167 Uncharacterized conserved protein, contains double-stranded beta-helix domain [Function unknown]; Region: COG1917 405955004168 Helix-turn-helix domain; Region: HTH_18; pfam12833 405955004169 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 405955004170 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955004171 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955004172 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405955004173 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955004174 putative substrate translocation pore; other site 405955004175 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955004176 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 405955004177 Smr domain; Region: Smr; pfam01713 405955004178 PAS domain S-box; Region: sensory_box; TIGR00229 405955004179 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405955004180 putative active site [active] 405955004181 heme pocket [chemical binding]; other site 405955004182 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405955004183 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955004184 metal binding site [ion binding]; metal-binding site 405955004185 active site 405955004186 I-site; other site 405955004187 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 405955004188 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 405955004189 Cl binding site [ion binding]; other site 405955004190 oligomer interface [polypeptide binding]; other site 405955004191 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 405955004192 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405955004193 ATP binding site [chemical binding]; other site 405955004194 Mg++ binding site [ion binding]; other site 405955004195 motif III; other site 405955004196 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405955004197 nucleotide binding region [chemical binding]; other site 405955004198 ATP-binding site [chemical binding]; other site 405955004199 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 405955004200 putative RNA binding site [nucleotide binding]; other site 405955004201 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 405955004202 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 405955004203 Ligand Binding Site [chemical binding]; other site 405955004204 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 405955004205 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 405955004206 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 405955004207 Int/Topo IB signature motif; other site 405955004208 hypothetical protein; Provisional; Region: PRK09750 405955004209 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 405955004210 exonuclease VIII; Reviewed; Region: PRK09709 405955004211 Enterobacterial exodeoxyribonuclease VIII; Region: Exonuc_VIII; pfam06630 405955004212 PDDEXK-like domain of unknown function (DUF3799); Region: DUF3799; pfam12684 405955004213 hypothetical protein; Reviewed; Region: PRK09790 405955004214 Superinfection exclusion protein B; Region: SieB; pfam14163 405955004215 transcriptional repressor DicA; Reviewed; Region: PRK09706 405955004216 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955004217 non-specific DNA binding site [nucleotide binding]; other site 405955004218 salt bridge; other site 405955004219 sequence-specific DNA binding site [nucleotide binding]; other site 405955004220 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 405955004221 primosomal protein DnaI; Provisional; Region: PRK02854 405955004222 putative replication protein; Provisional; Region: PRK12377 405955004223 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955004224 Walker A motif; other site 405955004225 ATP binding site [chemical binding]; other site 405955004226 Walker B motif; other site 405955004227 arginine finger; other site 405955004228 Protein of unknown function (DUF1627); Region: DUF1627; pfam07789 405955004229 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 405955004230 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1636 405955004231 Prophage maintenance system killer protein [General function prediction only]; Region: Doc; COG3654 405955004232 Protein of unknown function (DUF1367); Region: DUF1367; pfam07105 405955004233 Protein of unknown function (DUF1133); Region: DUF1133; pfam06576 405955004234 Lysis protein S; Region: Lysis_S; pfam04971 405955004235 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 405955004236 catalytic residues [active] 405955004237 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 405955004238 Cation transport protein; Region: TrkH; cl17365 405955004239 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 405955004240 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 405955004241 ParB-like nuclease domain; Region: ParBc; pfam02195 405955004242 Terminase small subunit; Region: Terminase_2; cl01513 405955004243 Phage terminase large subunit; Region: Terminase_3; cl12054 405955004244 Terminase-like family; Region: Terminase_6; pfam03237 405955004245 Domain of unknown function (DUF4055); Region: DUF4055; pfam13264 405955004246 Phage Mu protein F like protein; Region: Phage_Mu_F; cl10072 405955004247 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 405955004248 Bacteriophage related domain of unknown function; Region: DUF4128; pfam13554 405955004249 Phage-related minor tail protein [Function unknown]; Region: COG5281 405955004250 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 405955004251 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 405955004252 Phage minor tail protein; Region: Phage_min_tail; pfam05939 405955004253 Phage-related protein [Function unknown]; Region: gp18; COG4672 405955004254 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 405955004255 MPN+ (JAMM) motif; other site 405955004256 Zinc-binding site [ion binding]; other site 405955004257 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405955004258 NlpC/P60 family; Region: NLPC_P60; cl17555 405955004259 Phage-related protein, tail component [Function unknown]; Region: COG4723 405955004260 Phage-related protein, tail component [Function unknown]; Region: COG4733 405955004261 Putative phage tail protein; Region: Phage-tail_3; pfam13550 405955004262 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 405955004263 Fibronectin type III protein; Region: DUF3672; pfam12421 405955004264 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 405955004265 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 405955004266 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 405955004267 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 405955004268 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 405955004269 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 405955004270 Ricin-type beta-trefoil; Carbohydrate-binding domain formed from presumed gene triplication. The domain is found in a variety of molecules serving diverse functions such as enzymatic activity, inhibitory toxicity and signal transduction. Highly specific...; Region: RICIN; cl15820 405955004271 CdtB, the catalytic DNase I-like subunit of cytolethal distending toxin (CDT) protein; Region: CdtB; cd09081 405955004272 putative catalytic site [active] 405955004273 CdtC interface [polypeptide binding]; other site 405955004274 heterotrimer interface [polypeptide binding]; other site 405955004275 CdtA interface [polypeptide binding]; other site 405955004276 putative metal binding site [ion binding]; other site 405955004277 putative phosphate binding site [ion binding]; other site 405955004278 Cytolethal distending toxin A/C family; Region: CDtoxinA; pfam03498 405955004279 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 405955004280 TAP-like protein; Region: Abhydrolase_4; pfam08386 405955004281 outer membrane protease; Reviewed; Region: PRK10993 405955004282 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405955004283 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 405955004284 DNA binding site [nucleotide binding] 405955004285 active site 405955004286 Int/Topo IB signature motif; other site 405955004287 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405955004288 Ligand Binding Site [chemical binding]; other site 405955004289 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 405955004290 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 405955004291 trimer interface [polypeptide binding]; other site 405955004292 eyelet of channel; other site 405955004293 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 405955004294 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 405955004295 dimer interface [polypeptide binding]; other site 405955004296 PYR/PP interface [polypeptide binding]; other site 405955004297 TPP binding site [chemical binding]; other site 405955004298 substrate binding site [chemical binding]; other site 405955004299 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 405955004300 Domain of unknown function; Region: EKR; smart00890 405955004301 4Fe-4S binding domain; Region: Fer4_6; pfam12837 405955004302 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405955004303 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 405955004304 TPP-binding site [chemical binding]; other site 405955004305 dimer interface [polypeptide binding]; other site 405955004306 metabolite-proton symporter; Region: 2A0106; TIGR00883 405955004307 heat-inducible protein; Provisional; Region: PRK10449 405955004308 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 405955004309 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 405955004310 putative ligand binding site [chemical binding]; other site 405955004311 putative NAD binding site [chemical binding]; other site 405955004312 catalytic site [active] 405955004313 hypothetical protein; Provisional; Region: PRK10695 405955004314 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 405955004315 Autotransporter beta-domain; Region: Autotransporter; pfam03797 405955004316 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405955004317 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405955004318 active site 405955004319 catalytic tetrad [active] 405955004320 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 405955004321 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 405955004322 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 405955004323 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 405955004324 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405955004325 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955004326 S-adenosylmethionine binding site [chemical binding]; other site 405955004327 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 405955004328 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405955004329 active site 405955004330 Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr; Region: PTPc; cl00053 405955004331 active site 405955004332 catalytic residues [active] 405955004333 probable pectinesterase/pectinesterase inhibitor; Region: PLN02488 405955004334 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 405955004335 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405955004336 ATP binding site [chemical binding]; other site 405955004337 putative Mg++ binding site [ion binding]; other site 405955004338 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405955004339 nucleotide binding region [chemical binding]; other site 405955004340 ATP-binding site [chemical binding]; other site 405955004341 Helicase associated domain (HA2); Region: HA2; pfam04408 405955004342 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 405955004343 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 405955004344 Uncharacterized conserved protein [Function unknown]; Region: COG1434 405955004345 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405955004346 putative active site [active] 405955004347 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 405955004348 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405955004349 NAD binding site [chemical binding]; other site 405955004350 catalytic residues [active] 405955004351 substrate binding site [chemical binding]; other site 405955004352 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 405955004353 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 405955004354 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405955004355 cytochrome b561; Provisional; Region: PRK11513 405955004356 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405955004357 dimer interface [polypeptide binding]; other site 405955004358 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 405955004359 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955004360 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 405955004361 dimerization interface [polypeptide binding]; other site 405955004362 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 405955004363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 405955004364 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 405955004365 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 405955004366 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 405955004367 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405955004368 Coenzyme A binding pocket [chemical binding]; other site 405955004369 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 405955004370 putative trimer interface [polypeptide binding]; other site 405955004371 putative CoA binding site [chemical binding]; other site 405955004372 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 405955004373 putative trimer interface [polypeptide binding]; other site 405955004374 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 405955004375 putative CoA binding site [chemical binding]; other site 405955004376 putative trimer interface [polypeptide binding]; other site 405955004377 putative CoA binding site [chemical binding]; other site 405955004378 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 405955004379 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 405955004380 gating phenylalanine in ion channel; other site 405955004381 tellurite resistance protein TehB; Provisional; Region: PRK11207 405955004382 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955004383 S-adenosylmethionine binding site [chemical binding]; other site 405955004384 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 405955004385 benzoate transporter; Region: benE; TIGR00843 405955004386 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 405955004387 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405955004388 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955004389 non-specific DNA binding site [nucleotide binding]; other site 405955004390 salt bridge; other site 405955004391 sequence-specific DNA binding site [nucleotide binding]; other site 405955004392 Cupin domain; Region: Cupin_2; pfam07883 405955004393 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 405955004394 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 405955004395 Peptidase family U32; Region: Peptidase_U32; pfam01136 405955004396 Collagenase; Region: DUF3656; pfam12392 405955004397 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405955004398 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955004399 DNA-binding site [nucleotide binding]; DNA binding site 405955004400 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405955004401 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955004402 homodimer interface [polypeptide binding]; other site 405955004403 catalytic residue [active] 405955004404 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 405955004405 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 405955004406 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 405955004407 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955004408 Walker A/P-loop; other site 405955004409 ATP binding site [chemical binding]; other site 405955004410 Q-loop/lid; other site 405955004411 ABC transporter signature motif; other site 405955004412 Walker B; other site 405955004413 D-loop; other site 405955004414 H-loop/switch region; other site 405955004415 TOBE domain; Region: TOBE_2; pfam08402 405955004416 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955004417 dimer interface [polypeptide binding]; other site 405955004418 conserved gate region; other site 405955004419 putative PBP binding loops; other site 405955004420 ABC-ATPase subunit interface; other site 405955004421 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 405955004422 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955004423 ABC-ATPase subunit interface; other site 405955004424 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 405955004425 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 405955004426 tetrameric interface [polypeptide binding]; other site 405955004427 NAD binding site [chemical binding]; other site 405955004428 catalytic residues [active] 405955004429 substrate binding site [chemical binding]; other site 405955004430 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 405955004431 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 405955004432 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405955004433 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 405955004434 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 405955004435 N-terminal plug; other site 405955004436 ligand-binding site [chemical binding]; other site 405955004437 PQQ-like domain; Region: PQQ_2; pfam13360 405955004438 L-asparagine permease; Provisional; Region: PRK15049 405955004439 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 405955004440 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 405955004441 N-terminal domain interface [polypeptide binding]; other site 405955004442 dimer interface [polypeptide binding]; other site 405955004443 substrate binding pocket (H-site) [chemical binding]; other site 405955004444 PAAR motif; Region: PAAR_motif; pfam05488 405955004445 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 405955004446 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 405955004447 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 405955004448 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 405955004449 Peptidase M35-like domain of uncharacterized proteins; Region: M35_like_1; cd11007 405955004450 putative active site [active] 405955004451 putative Zn binding site [ion binding]; other site 405955004452 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 405955004453 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 405955004454 hypothetical protein; Provisional; Region: PRK10281 405955004455 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 405955004456 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 405955004457 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 405955004458 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 405955004459 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 405955004460 [4Fe-4S] binding site [ion binding]; other site 405955004461 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405955004462 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405955004463 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405955004464 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 405955004465 molybdopterin cofactor binding site; other site 405955004466 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 405955004467 aromatic amino acid exporter; Provisional; Region: PRK11689 405955004468 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405955004469 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405955004470 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 405955004471 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 405955004472 molybdopterin cofactor binding site; other site 405955004473 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 405955004474 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 405955004475 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 405955004476 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955004477 non-specific DNA binding site [nucleotide binding]; other site 405955004478 salt bridge; other site 405955004479 sequence-specific DNA binding site [nucleotide binding]; other site 405955004480 Plasmid maintenance system killer protein; Region: Plasmid_killer; pfam05015 405955004481 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 405955004482 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 405955004483 NAD binding site [chemical binding]; other site 405955004484 substrate binding site [chemical binding]; other site 405955004485 catalytic Zn binding site [ion binding]; other site 405955004486 tetramer interface [polypeptide binding]; other site 405955004487 structural Zn binding site [ion binding]; other site 405955004488 malate dehydrogenase; Provisional; Region: PRK13529 405955004489 Malic enzyme, N-terminal domain; Region: malic; pfam00390 405955004490 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 405955004491 NAD(P) binding site [chemical binding]; other site 405955004492 Putative biofilm-dependent modulation protein; Region: BDM; pfam10684 405955004493 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 405955004494 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 405955004495 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405955004496 putative active site [active] 405955004497 heme pocket [chemical binding]; other site 405955004498 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405955004499 putative active site [active] 405955004500 heme pocket [chemical binding]; other site 405955004501 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955004502 metal binding site [ion binding]; metal-binding site 405955004503 active site 405955004504 I-site; other site 405955004505 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955004506 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 405955004507 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 405955004508 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 405955004509 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 405955004510 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955004511 catalytic residue [active] 405955004512 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405955004513 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 405955004514 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405955004515 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405955004516 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405955004517 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 405955004518 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 405955004519 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 405955004520 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 405955004521 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 405955004522 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 405955004523 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955004524 FeS/SAM binding site; other site 405955004525 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 405955004526 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 405955004527 Sulfatase; Region: Sulfatase; pfam00884 405955004528 transcriptional regulator YdeO; Provisional; Region: PRK09940 405955004529 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955004530 putative oxidoreductase; Provisional; Region: PRK09939 405955004531 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 405955004532 putative molybdopterin cofactor binding site [chemical binding]; other site 405955004533 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 405955004534 putative molybdopterin cofactor binding site; other site 405955004535 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 405955004536 mannosyl binding site [chemical binding]; other site 405955004537 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 405955004538 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 405955004539 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 405955004540 PapC N-terminal domain; Region: PapC_N; pfam13954 405955004541 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 405955004542 PapC C-terminal domain; Region: PapC_C; pfam13953 405955004543 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 405955004544 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 405955004545 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 405955004546 Fimbrial protein; Region: Fimbrial; cl01416 405955004547 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 405955004548 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405955004549 NAD(P) binding site [chemical binding]; other site 405955004550 putative active site [active] 405955004551 HipA N-terminal domain; Region: Couple_hipA; pfam13657 405955004552 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 405955004553 HipA-like N-terminal domain; Region: HipA_N; pfam07805 405955004554 HipA-like C-terminal domain; Region: HipA_C; pfam07804 405955004555 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405955004556 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955004557 non-specific DNA binding site [nucleotide binding]; other site 405955004558 salt bridge; other site 405955004559 sequence-specific DNA binding site [nucleotide binding]; other site 405955004560 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 405955004561 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955004562 S-adenosylmethionine binding site [chemical binding]; other site 405955004563 Predicted membrane protein [Function unknown]; Region: COG3781 405955004564 altronate oxidoreductase; Provisional; Region: PRK03643 405955004565 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 405955004566 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 405955004567 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405955004568 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955004569 metal binding site [ion binding]; metal-binding site 405955004570 active site 405955004571 I-site; other site 405955004572 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 405955004573 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 405955004574 glutaminase; Provisional; Region: PRK00971 405955004575 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 405955004576 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 405955004577 NAD(P) binding site [chemical binding]; other site 405955004578 catalytic residues [active] 405955004579 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405955004580 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955004581 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 405955004582 putative dimerization interface [polypeptide binding]; other site 405955004583 putative arabinose transporter; Provisional; Region: PRK03545 405955004584 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955004585 putative substrate translocation pore; other site 405955004586 inner membrane protein; Provisional; Region: PRK10995 405955004587 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 405955004588 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405955004589 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 405955004590 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955004591 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955004592 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 405955004593 beta-galactosidase; Region: BGL; TIGR03356 405955004594 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 405955004595 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 405955004596 trimer interface; other site 405955004597 sugar binding site [chemical binding]; other site 405955004598 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 405955004599 active site 405955004600 methionine cluster; other site 405955004601 phosphorylation site [posttranslational modification] 405955004602 metal binding site [ion binding]; metal-binding site 405955004603 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 405955004604 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 405955004605 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405955004606 active site 405955004607 P-loop; other site 405955004608 phosphorylation site [posttranslational modification] 405955004609 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405955004610 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955004611 DNA-binding site [nucleotide binding]; DNA binding site 405955004612 UTRA domain; Region: UTRA; pfam07702 405955004613 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 405955004614 EamA-like transporter family; Region: EamA; pfam00892 405955004615 EamA-like transporter family; Region: EamA; pfam00892 405955004616 putative transporter; Provisional; Region: PRK10054 405955004617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955004618 putative substrate translocation pore; other site 405955004619 diguanylate cyclase; Provisional; Region: PRK09894 405955004620 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 405955004621 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955004622 metal binding site [ion binding]; metal-binding site 405955004623 active site 405955004624 I-site; other site 405955004625 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 405955004626 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 405955004627 active site 405955004628 Zn binding site [ion binding]; other site 405955004629 malonic semialdehyde reductase; Provisional; Region: PRK10538 405955004630 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 405955004631 putative NAD(P) binding site [chemical binding]; other site 405955004632 homodimer interface [polypeptide binding]; other site 405955004633 homotetramer interface [polypeptide binding]; other site 405955004634 active site 405955004635 Transcriptional regulators [Transcription]; Region: GntR; COG1802 405955004636 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955004637 DNA-binding site [nucleotide binding]; DNA binding site 405955004638 FCD domain; Region: FCD; pfam07729 405955004639 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 405955004640 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 405955004641 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 405955004642 putative oxidoreductase; Provisional; Region: PRK10083 405955004643 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 405955004644 putative NAD(P) binding site [chemical binding]; other site 405955004645 catalytic Zn binding site [ion binding]; other site 405955004646 structural Zn binding site [ion binding]; other site 405955004647 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 405955004648 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 405955004649 putative active site pocket [active] 405955004650 putative metal binding site [ion binding]; other site 405955004651 hypothetical protein; Provisional; Region: PRK02237 405955004652 hypothetical protein; Provisional; Region: PRK13659 405955004653 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 405955004654 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405955004655 Coenzyme A binding pocket [chemical binding]; other site 405955004656 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 405955004657 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 405955004658 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 405955004659 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 405955004660 putative [Fe4-S4] binding site [ion binding]; other site 405955004661 putative molybdopterin cofactor binding site [chemical binding]; other site 405955004662 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 405955004663 putative molybdopterin cofactor binding site; other site 405955004664 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 405955004665 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 405955004666 putative [Fe4-S4] binding site [ion binding]; other site 405955004667 putative molybdopterin cofactor binding site [chemical binding]; other site 405955004668 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 405955004669 putative molybdopterin cofactor binding site; other site 405955004670 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 405955004671 4Fe-4S binding domain; Region: Fer4; cl02805 405955004672 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 405955004673 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 405955004674 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 405955004675 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 405955004676 Cl- selectivity filter; other site 405955004677 Cl- binding residues [ion binding]; other site 405955004678 pore gating glutamate residue; other site 405955004679 dimer interface [polypeptide binding]; other site 405955004680 putative dithiobiotin synthetase; Provisional; Region: PRK12374 405955004681 AAA domain; Region: AAA_26; pfam13500 405955004682 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 405955004683 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 405955004684 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405955004685 nucleotide binding site [chemical binding]; other site 405955004686 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 405955004687 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955004688 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 405955004689 dimerization interface [polypeptide binding]; other site 405955004690 substrate binding pocket [chemical binding]; other site 405955004691 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405955004692 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955004693 putative substrate translocation pore; other site 405955004694 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 405955004695 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 405955004696 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 405955004697 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 405955004698 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405955004699 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 405955004700 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 405955004701 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 405955004702 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 405955004703 ligand binding site [chemical binding]; other site 405955004704 homodimer interface [polypeptide binding]; other site 405955004705 NAD(P) binding site [chemical binding]; other site 405955004706 trimer interface B [polypeptide binding]; other site 405955004707 trimer interface A [polypeptide binding]; other site 405955004708 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 405955004709 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 405955004710 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 405955004711 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 405955004712 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 405955004713 Spore germination protein; Region: Spore_permease; cl17796 405955004714 dihydromonapterin reductase; Provisional; Region: PRK06483 405955004715 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 405955004716 NADP binding site [chemical binding]; other site 405955004717 substrate binding pocket [chemical binding]; other site 405955004718 active site 405955004719 GlpM protein; Region: GlpM; pfam06942 405955004720 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 405955004721 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955004722 active site 405955004723 phosphorylation site [posttranslational modification] 405955004724 intermolecular recognition site; other site 405955004725 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955004726 DNA binding site [nucleotide binding] 405955004727 sensor protein RstB; Provisional; Region: PRK10604 405955004728 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405955004729 dimerization interface [polypeptide binding]; other site 405955004730 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955004731 dimer interface [polypeptide binding]; other site 405955004732 phosphorylation site [posttranslational modification] 405955004733 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955004734 ATP binding site [chemical binding]; other site 405955004735 Mg2+ binding site [ion binding]; other site 405955004736 G-X-G motif; other site 405955004737 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 405955004738 fumarate hydratase; Reviewed; Region: fumC; PRK00485 405955004739 Class II fumarases; Region: Fumarase_classII; cd01362 405955004740 active site 405955004741 tetramer interface [polypeptide binding]; other site 405955004742 fumarate hydratase; Provisional; Region: PRK15389 405955004743 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 405955004744 Fumarase C-terminus; Region: Fumerase_C; pfam05683 405955004745 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 405955004746 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 405955004747 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 405955004748 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 405955004749 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 405955004750 putative outer membrane porin protein; Provisional; Region: PRK11379 405955004751 glucuronide transporter; Provisional; Region: PRK09848 405955004752 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 405955004753 beta-D-glucuronidase; Provisional; Region: PRK10150 405955004754 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 405955004755 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 405955004756 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 405955004757 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405955004758 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955004759 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 405955004760 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 405955004761 NAD binding site [chemical binding]; other site 405955004762 substrate binding site [chemical binding]; other site 405955004763 homotetramer interface [polypeptide binding]; other site 405955004764 homodimer interface [polypeptide binding]; other site 405955004765 active site 405955004766 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 405955004767 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955004768 DNA binding site [nucleotide binding] 405955004769 domain linker motif; other site 405955004770 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 405955004771 putative dimerization interface [polypeptide binding]; other site 405955004772 putative ligand binding site [chemical binding]; other site 405955004773 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 405955004774 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 405955004775 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405955004776 active site turn [active] 405955004777 phosphorylation site [posttranslational modification] 405955004778 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 405955004779 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405955004780 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955004781 homodimer interface [polypeptide binding]; other site 405955004782 catalytic residue [active] 405955004783 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 405955004784 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 405955004785 active site 405955004786 purine riboside binding site [chemical binding]; other site 405955004787 putative oxidoreductase; Provisional; Region: PRK11579 405955004788 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405955004789 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405955004790 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 405955004791 electron transport complex protein RsxA; Provisional; Region: PRK05151 405955004792 electron transport complex protein RnfB; Provisional; Region: PRK05113 405955004793 Putative Fe-S cluster; Region: FeS; pfam04060 405955004794 4Fe-4S binding domain; Region: Fer4; pfam00037 405955004795 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 405955004796 SLBB domain; Region: SLBB; pfam10531 405955004797 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405955004798 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 405955004799 electron transport complex protein RnfG; Validated; Region: PRK01908 405955004800 electron transport complex RsxE subunit; Provisional; Region: PRK12405 405955004801 endonuclease III; Provisional; Region: PRK10702 405955004802 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405955004803 minor groove reading motif; other site 405955004804 helix-hairpin-helix signature motif; other site 405955004805 substrate binding pocket [chemical binding]; other site 405955004806 active site 405955004807 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 405955004808 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 405955004809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955004810 putative substrate translocation pore; other site 405955004811 POT family; Region: PTR2; pfam00854 405955004812 glutathionine S-transferase; Provisional; Region: PRK10542 405955004813 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 405955004814 C-terminal domain interface [polypeptide binding]; other site 405955004815 GSH binding site (G-site) [chemical binding]; other site 405955004816 dimer interface [polypeptide binding]; other site 405955004817 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 405955004818 N-terminal domain interface [polypeptide binding]; other site 405955004819 dimer interface [polypeptide binding]; other site 405955004820 substrate binding pocket (H-site) [chemical binding]; other site 405955004821 pyridoxamine kinase; Validated; Region: PRK05756 405955004822 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 405955004823 dimer interface [polypeptide binding]; other site 405955004824 pyridoxal binding site [chemical binding]; other site 405955004825 ATP binding site [chemical binding]; other site 405955004826 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 405955004827 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 405955004828 active site 405955004829 HIGH motif; other site 405955004830 dimer interface [polypeptide binding]; other site 405955004831 KMSKS motif; other site 405955004832 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405955004833 RNA binding surface [nucleotide binding]; other site 405955004834 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 405955004835 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 405955004836 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 405955004837 lysozyme inhibitor; Provisional; Region: PRK11372 405955004838 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 405955004839 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 405955004840 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 405955004841 transcriptional regulator SlyA; Provisional; Region: PRK03573 405955004842 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 405955004843 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 405955004844 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955004845 Fusaric acid resistance protein family; Region: FUSC; pfam04632 405955004846 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 405955004847 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 405955004848 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 405955004849 E-class dimer interface [polypeptide binding]; other site 405955004850 P-class dimer interface [polypeptide binding]; other site 405955004851 active site 405955004852 Cu2+ binding site [ion binding]; other site 405955004853 Zn2+ binding site [ion binding]; other site 405955004854 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405955004855 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405955004856 active site 405955004857 catalytic tetrad [active] 405955004858 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405955004859 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955004860 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 405955004861 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 405955004862 FMN binding site [chemical binding]; other site 405955004863 active site 405955004864 substrate binding site [chemical binding]; other site 405955004865 catalytic residue [active] 405955004866 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405955004867 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 405955004868 dimer interface [polypeptide binding]; other site 405955004869 active site 405955004870 metal binding site [ion binding]; metal-binding site 405955004871 glutathione binding site [chemical binding]; other site 405955004872 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 405955004873 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 405955004874 dimer interface [polypeptide binding]; other site 405955004875 catalytic site [active] 405955004876 putative active site [active] 405955004877 putative substrate binding site [chemical binding]; other site 405955004878 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 405955004879 putative GSH binding site [chemical binding]; other site 405955004880 catalytic residues [active] 405955004881 superoxide dismutase; Provisional; Region: PRK10543 405955004882 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 405955004883 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 405955004884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955004885 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405955004886 putative substrate translocation pore; other site 405955004887 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 405955004888 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955004889 DNA binding site [nucleotide binding] 405955004890 domain linker motif; other site 405955004891 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 405955004892 dimerization interface [polypeptide binding]; other site 405955004893 ligand binding site [chemical binding]; other site 405955004894 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 405955004895 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955004896 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 405955004897 dimerization interface [polypeptide binding]; other site 405955004898 putative transporter; Provisional; Region: PRK11043 405955004899 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955004900 putative substrate translocation pore; other site 405955004901 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 405955004902 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 405955004903 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955004904 S-adenosylmethionine binding site [chemical binding]; other site 405955004905 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 405955004906 Lumazine binding domain; Region: Lum_binding; pfam00677 405955004907 Lumazine binding domain; Region: Lum_binding; pfam00677 405955004908 multidrug efflux protein; Reviewed; Region: PRK01766 405955004909 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 405955004910 cation binding site [ion binding]; other site 405955004911 hypothetical protein; Provisional; Region: PRK09945 405955004912 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 405955004913 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 405955004914 hypothetical protein; Provisional; Region: PRK09897 405955004915 hypothetical protein; Provisional; Region: PRK09946 405955004916 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 405955004917 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 405955004918 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 405955004919 hypothetical protein; Provisional; Region: PRK09947 405955004920 putative oxidoreductase; Provisional; Region: PRK09849 405955004921 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 405955004922 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 405955004923 hypothetical protein; Provisional; Region: PRK09898 405955004924 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405955004925 pyruvate kinase; Provisional; Region: PRK09206 405955004926 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 405955004927 active site 405955004928 domain interfaces; other site 405955004929 L,D-transpeptidase; Provisional; Region: PRK10190 405955004930 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405955004931 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405955004932 cysteine desufuration protein SufE; Provisional; Region: PRK09296 405955004933 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 405955004934 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 405955004935 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405955004936 catalytic residue [active] 405955004937 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 405955004938 FeS assembly protein SufD; Region: sufD; TIGR01981 405955004939 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 405955004940 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 405955004941 Walker A/P-loop; other site 405955004942 ATP binding site [chemical binding]; other site 405955004943 Q-loop/lid; other site 405955004944 ABC transporter signature motif; other site 405955004945 Walker B; other site 405955004946 D-loop; other site 405955004947 H-loop/switch region; other site 405955004948 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 405955004949 putative ABC transporter; Region: ycf24; CHL00085 405955004950 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 405955004951 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 405955004952 CoenzymeA binding site [chemical binding]; other site 405955004953 subunit interaction site [polypeptide binding]; other site 405955004954 PHB binding site; other site 405955004955 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 405955004956 FAD binding domain; Region: FAD_binding_4; pfam01565 405955004957 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 405955004958 putative inner membrane protein; Provisional; Region: PRK10983 405955004959 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405955004960 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955004961 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405955004962 putative substrate translocation pore; other site 405955004963 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955004964 putative substrate translocation pore; other site 405955004965 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 405955004966 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 405955004967 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 405955004968 shikimate binding site; other site 405955004969 NAD(P) binding site [chemical binding]; other site 405955004970 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 405955004971 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 405955004972 active site 405955004973 catalytic residue [active] 405955004974 dimer interface [polypeptide binding]; other site 405955004975 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 405955004976 Coenzyme A transferase; Region: CoA_trans; smart00882 405955004977 Coenzyme A transferase; Region: CoA_trans; cl17247 405955004978 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 405955004979 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 405955004980 active site 405955004981 Cupin domain; Region: Cupin_2; pfam07883 405955004982 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 405955004983 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405955004984 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955004985 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 405955004986 Ligand binding site [chemical binding]; other site 405955004987 Electron transfer flavoprotein domain; Region: ETF; pfam01012 405955004988 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 405955004989 Electron transfer flavoprotein domain; Region: ETF; smart00893 405955004990 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 405955004991 oxidoreductase; Provisional; Region: PRK10015 405955004992 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 405955004993 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 405955004994 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 405955004995 acyl-activating enzyme (AAE) consensus motif; other site 405955004996 putative AMP binding site [chemical binding]; other site 405955004997 putative active site [active] 405955004998 putative CoA binding site [chemical binding]; other site 405955004999 phosphoenolpyruvate synthase; Validated; Region: PRK06464 405955005000 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 405955005001 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405955005002 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 405955005003 PEP synthetase regulatory protein; Provisional; Region: PRK05339 405955005004 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 405955005005 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 405955005006 Uncharacterized conserved protein [Function unknown]; Region: COG0397 405955005007 hypothetical protein; Validated; Region: PRK00029 405955005008 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 405955005009 NlpC/P60 family; Region: NLPC_P60; pfam00877 405955005010 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 405955005011 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405955005012 Walker A/P-loop; other site 405955005013 ATP binding site [chemical binding]; other site 405955005014 Q-loop/lid; other site 405955005015 ABC transporter signature motif; other site 405955005016 Walker B; other site 405955005017 D-loop; other site 405955005018 H-loop/switch region; other site 405955005019 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 405955005020 catalytic residues [active] 405955005021 dimer interface [polypeptide binding]; other site 405955005022 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405955005023 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955005024 ABC-ATPase subunit interface; other site 405955005025 dimer interface [polypeptide binding]; other site 405955005026 putative PBP binding regions; other site 405955005027 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 405955005028 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 405955005029 putative tRNA-binding site [nucleotide binding]; other site 405955005030 B3/4 domain; Region: B3_4; pfam03483 405955005031 tRNA synthetase B5 domain; Region: B5; smart00874 405955005032 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 405955005033 dimer interface [polypeptide binding]; other site 405955005034 motif 1; other site 405955005035 motif 3; other site 405955005036 motif 2; other site 405955005037 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 405955005038 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 405955005039 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 405955005040 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 405955005041 dimer interface [polypeptide binding]; other site 405955005042 motif 1; other site 405955005043 active site 405955005044 motif 2; other site 405955005045 motif 3; other site 405955005046 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 405955005047 23S rRNA binding site [nucleotide binding]; other site 405955005048 L21 binding site [polypeptide binding]; other site 405955005049 L13 binding site [polypeptide binding]; other site 405955005050 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 405955005051 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 405955005052 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 405955005053 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 405955005054 active site 405955005055 dimer interface [polypeptide binding]; other site 405955005056 motif 1; other site 405955005057 motif 2; other site 405955005058 motif 3; other site 405955005059 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 405955005060 anticodon binding site; other site 405955005061 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 405955005062 6-phosphofructokinase 2; Provisional; Region: PRK10294 405955005063 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 405955005064 putative substrate binding site [chemical binding]; other site 405955005065 putative ATP binding site [chemical binding]; other site 405955005066 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 405955005067 Phosphotransferase enzyme family; Region: APH; pfam01636 405955005068 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 405955005069 active site 405955005070 ATP binding site [chemical binding]; other site 405955005071 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 405955005072 YniB-like protein; Region: YniB; pfam14002 405955005073 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 405955005074 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405955005075 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955005076 motif II; other site 405955005077 inner membrane protein; Provisional; Region: PRK11648 405955005078 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 405955005079 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405955005080 cell division modulator; Provisional; Region: PRK10113 405955005081 hydroperoxidase II; Provisional; Region: katE; PRK11249 405955005082 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 405955005083 tetramer interface [polypeptide binding]; other site 405955005084 heme binding pocket [chemical binding]; other site 405955005085 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 405955005086 domain interactions; other site 405955005087 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 405955005088 putative active site [active] 405955005089 YdjC motif; other site 405955005090 Mg binding site [ion binding]; other site 405955005091 putative homodimer interface [polypeptide binding]; other site 405955005092 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 405955005093 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 405955005094 NAD binding site [chemical binding]; other site 405955005095 sugar binding site [chemical binding]; other site 405955005096 divalent metal binding site [ion binding]; other site 405955005097 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405955005098 dimer interface [polypeptide binding]; other site 405955005099 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 405955005100 Cupin domain; Region: Cupin_2; pfam07883 405955005101 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955005102 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 405955005103 methionine cluster; other site 405955005104 active site 405955005105 phosphorylation site [posttranslational modification] 405955005106 metal binding site [ion binding]; metal-binding site 405955005107 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 405955005108 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 405955005109 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 405955005110 active site 405955005111 P-loop; other site 405955005112 phosphorylation site [posttranslational modification] 405955005113 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 405955005114 NAD+ synthetase; Region: nadE; TIGR00552 405955005115 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 405955005116 homodimer interface [polypeptide binding]; other site 405955005117 NAD binding pocket [chemical binding]; other site 405955005118 ATP binding pocket [chemical binding]; other site 405955005119 Mg binding site [ion binding]; other site 405955005120 active-site loop [active] 405955005121 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 405955005122 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 405955005123 GIY-YIG motif/motif A; other site 405955005124 active site 405955005125 catalytic site [active] 405955005126 putative DNA binding site [nucleotide binding]; other site 405955005127 metal binding site [ion binding]; metal-binding site 405955005128 hypothetical protein; Provisional; Region: PRK11396 405955005129 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 405955005130 dimer interface [polypeptide binding]; other site 405955005131 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 405955005132 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 405955005133 putative active site [active] 405955005134 Zn binding site [ion binding]; other site 405955005135 succinylarginine dihydrolase; Provisional; Region: PRK13281 405955005136 succinylglutamic semialdehyde dehydrogenase; Region: arg_catab_astD; TIGR03240 405955005137 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 405955005138 NAD(P) binding site [chemical binding]; other site 405955005139 catalytic residues [active] 405955005140 arginine succinyltransferase; Provisional; Region: PRK10456 405955005141 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 405955005142 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 405955005143 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405955005144 inhibitor-cofactor binding pocket; inhibition site 405955005145 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955005146 catalytic residue [active] 405955005147 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 405955005148 putative catalytic site [active] 405955005149 putative phosphate binding site [ion binding]; other site 405955005150 active site 405955005151 metal binding site A [ion binding]; metal-binding site 405955005152 DNA binding site [nucleotide binding] 405955005153 putative AP binding site [nucleotide binding]; other site 405955005154 putative metal binding site B [ion binding]; other site 405955005155 Uncharacterized conserved protein [Function unknown]; Region: COG0398 405955005156 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405955005157 Uncharacterized conserved protein [Function unknown]; Region: COG0398 405955005158 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405955005159 Uncharacterized conserved protein [Function unknown]; Region: COG2128 405955005160 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 405955005161 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 405955005162 hypothetical protein; Provisional; Region: PRK11622 405955005163 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 405955005164 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955005165 dimer interface [polypeptide binding]; other site 405955005166 conserved gate region; other site 405955005167 putative PBP binding loops; other site 405955005168 ABC-ATPase subunit interface; other site 405955005169 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 405955005170 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955005171 Walker A/P-loop; other site 405955005172 ATP binding site [chemical binding]; other site 405955005173 Q-loop/lid; other site 405955005174 ABC transporter signature motif; other site 405955005175 Walker B; other site 405955005176 D-loop; other site 405955005177 H-loop/switch region; other site 405955005178 Rhodanese Homology Domain; Region: RHOD; smart00450 405955005179 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 405955005180 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 405955005181 active site residue [active] 405955005182 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 405955005183 active site residue [active] 405955005184 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 405955005185 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 405955005186 active site 405955005187 8-oxo-dGMP binding site [chemical binding]; other site 405955005188 nudix motif; other site 405955005189 metal binding site [ion binding]; metal-binding site 405955005190 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 405955005191 glutamate dehydrogenase; Provisional; Region: PRK09414 405955005192 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 405955005193 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 405955005194 NAD(P) binding site [chemical binding]; other site 405955005195 DNA topoisomerase III; Provisional; Region: PRK07726 405955005196 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 405955005197 active site 405955005198 putative interdomain interaction site [polypeptide binding]; other site 405955005199 putative metal-binding site [ion binding]; other site 405955005200 putative nucleotide binding site [chemical binding]; other site 405955005201 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 405955005202 domain I; other site 405955005203 DNA binding groove [nucleotide binding] 405955005204 phosphate binding site [ion binding]; other site 405955005205 domain II; other site 405955005206 domain III; other site 405955005207 nucleotide binding site [chemical binding]; other site 405955005208 catalytic site [active] 405955005209 domain IV; other site 405955005210 selenophosphate synthetase; Provisional; Region: PRK00943 405955005211 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 405955005212 dimerization interface [polypeptide binding]; other site 405955005213 putative ATP binding site [chemical binding]; other site 405955005214 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 405955005215 putative FMN binding site [chemical binding]; other site 405955005216 protease 4; Provisional; Region: PRK10949 405955005217 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 405955005218 tandem repeat interface [polypeptide binding]; other site 405955005219 oligomer interface [polypeptide binding]; other site 405955005220 active site residues [active] 405955005221 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 405955005222 tandem repeat interface [polypeptide binding]; other site 405955005223 oligomer interface [polypeptide binding]; other site 405955005224 active site residues [active] 405955005225 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 405955005226 active site 405955005227 homodimer interface [polypeptide binding]; other site 405955005228 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 405955005229 Isochorismatase family; Region: Isochorismatase; pfam00857 405955005230 catalytic triad [active] 405955005231 metal binding site [ion binding]; metal-binding site 405955005232 conserved cis-peptide bond; other site 405955005233 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 405955005234 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955005235 putative substrate translocation pore; other site 405955005236 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955005237 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405955005238 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 405955005239 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405955005240 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405955005241 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405955005242 active site 405955005243 catalytic tetrad [active] 405955005244 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405955005245 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 405955005246 substrate binding site [chemical binding]; other site 405955005247 ATP binding site [chemical binding]; other site 405955005248 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 405955005249 intersubunit interface [polypeptide binding]; other site 405955005250 active site 405955005251 zinc binding site [ion binding]; other site 405955005252 Na+ binding site [ion binding]; other site 405955005253 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405955005254 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 405955005255 inhibitor binding site; inhibition site 405955005256 catalytic Zn binding site [ion binding]; other site 405955005257 structural Zn binding site [ion binding]; other site 405955005258 NADP binding site [chemical binding]; other site 405955005259 tetramer interface [polypeptide binding]; other site 405955005260 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955005261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955005262 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405955005263 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 405955005264 putative NAD(P) binding site [chemical binding]; other site 405955005265 catalytic Zn binding site [ion binding]; other site 405955005266 structural Zn binding site [ion binding]; other site 405955005267 methionine sulfoxide reductase B; Provisional; Region: PRK00222 405955005268 SelR domain; Region: SelR; pfam01641 405955005269 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 405955005270 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 405955005271 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405955005272 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 405955005273 active site 405955005274 phosphate binding residues; other site 405955005275 catalytic residues [active] 405955005276 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405955005277 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405955005278 active site 405955005279 catalytic tetrad [active] 405955005280 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 405955005281 PrkA family serine protein kinase; Provisional; Region: PRK15455 405955005282 AAA ATPase domain; Region: AAA_16; pfam13191 405955005283 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 405955005284 hypothetical protein; Provisional; Region: PRK05325 405955005285 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405955005286 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955005287 metal binding site [ion binding]; metal-binding site 405955005288 active site 405955005289 I-site; other site 405955005290 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405955005291 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955005292 metal binding site [ion binding]; metal-binding site 405955005293 active site 405955005294 I-site; other site 405955005295 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 405955005296 putative deacylase active site [active] 405955005297 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405955005298 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955005299 cyanate transporter; Region: CynX; TIGR00896 405955005300 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955005301 Uncharacterized conserved protein [Function unknown]; Region: COG3189 405955005302 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 405955005303 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405955005304 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405955005305 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955005306 metal binding site [ion binding]; metal-binding site 405955005307 active site 405955005308 I-site; other site 405955005309 leucine export protein LeuE; Provisional; Region: PRK10958 405955005310 ribonuclease D; Provisional; Region: PRK10829 405955005311 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 405955005312 catalytic site [active] 405955005313 putative active site [active] 405955005314 putative substrate binding site [chemical binding]; other site 405955005315 Helicase and RNase D C-terminal; Region: HRDC; smart00341 405955005316 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 405955005317 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 405955005318 acyl-activating enzyme (AAE) consensus motif; other site 405955005319 putative AMP binding site [chemical binding]; other site 405955005320 putative active site [active] 405955005321 putative CoA binding site [chemical binding]; other site 405955005322 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 405955005323 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 405955005324 Glycoprotease family; Region: Peptidase_M22; pfam00814 405955005325 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 405955005326 DEAD/DEAH box helicase; Region: DEAD; pfam00270 405955005327 DEAD_2; Region: DEAD_2; pfam06733 405955005328 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 405955005329 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 405955005330 homotrimer interaction site [polypeptide binding]; other site 405955005331 putative active site [active] 405955005332 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 405955005333 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 405955005334 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 405955005335 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 405955005336 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 405955005337 putative active site [active] 405955005338 putative CoA binding site [chemical binding]; other site 405955005339 nudix motif; other site 405955005340 metal binding site [ion binding]; metal-binding site 405955005341 L-serine deaminase; Provisional; Region: PRK15023 405955005342 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 405955005343 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 405955005344 phage resistance protein; Provisional; Region: PRK10551 405955005345 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 405955005346 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955005347 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 405955005348 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405955005349 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405955005350 Transporter associated domain; Region: CorC_HlyC; smart01091 405955005351 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 405955005352 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 405955005353 active pocket/dimerization site; other site 405955005354 active site 405955005355 phosphorylation site [posttranslational modification] 405955005356 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 405955005357 active site 405955005358 phosphorylation site [posttranslational modification] 405955005359 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 405955005360 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 405955005361 Predicted membrane protein [Function unknown]; Region: COG4811 405955005362 hypothetical protein; Provisional; Region: PRK11469 405955005363 Domain of unknown function DUF; Region: DUF204; pfam02659 405955005364 Domain of unknown function DUF; Region: DUF204; pfam02659 405955005365 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 405955005366 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955005367 S-adenosylmethionine binding site [chemical binding]; other site 405955005368 YebO-like protein; Region: YebO; pfam13974 405955005369 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 405955005370 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405955005371 dimerization interface [polypeptide binding]; other site 405955005372 putative Zn2+ binding site [ion binding]; other site 405955005373 putative DNA binding site [nucleotide binding]; other site 405955005374 Bacterial transcriptional regulator; Region: IclR; pfam01614 405955005375 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955005376 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405955005377 putative substrate translocation pore; other site 405955005378 Predicted integral membrane protein [Function unknown]; Region: COG5521 405955005379 heat shock protein HtpX; Provisional; Region: PRK05457 405955005380 carboxy-terminal protease; Provisional; Region: PRK11186 405955005381 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 405955005382 protein binding site [polypeptide binding]; other site 405955005383 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 405955005384 Catalytic dyad [active] 405955005385 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 405955005386 ProP expression regulator; Provisional; Region: PRK04950 405955005387 ProQ/FINO family; Region: ProQ; pfam04352 405955005388 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 405955005389 Paraquat-inducible protein A; Region: PqiA; pfam04403 405955005390 Paraquat-inducible protein A; Region: PqiA; pfam04403 405955005391 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 405955005392 mce related protein; Region: MCE; pfam02470 405955005393 mce related protein; Region: MCE; pfam02470 405955005394 mce related protein; Region: MCE; pfam02470 405955005395 mce related protein; Region: MCE; pfam02470 405955005396 mce related protein; Region: MCE; pfam02470 405955005397 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 405955005398 NOL1/NOP2/sun family putative RNA methylase; Region: nop2p; TIGR00446 405955005399 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 405955005400 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 405955005401 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 405955005402 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405955005403 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 405955005404 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 405955005405 Predicted amidohydrolase [General function prediction only]; Region: COG0388 405955005406 Nitrilase superfamily, including nitrile- or amide-hydrolyzing enzymes and amide-condensing enzymes; Region: nitrilase; cl11424 405955005407 exodeoxyribonuclease X; Provisional; Region: PRK07983 405955005408 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405955005409 active site 405955005410 catalytic site [active] 405955005411 substrate binding site [chemical binding]; other site 405955005412 protease 2; Provisional; Region: PRK10115 405955005413 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405955005414 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 405955005415 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 405955005416 putative metal binding site [ion binding]; other site 405955005417 hypothetical protein; Provisional; Region: PRK13680 405955005418 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 405955005419 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405955005420 ATP-grasp domain; Region: ATP-grasp; pfam02222 405955005421 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 405955005422 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 405955005423 active site 405955005424 intersubunit interface [polypeptide binding]; other site 405955005425 catalytic residue [active] 405955005426 phosphogluconate dehydratase; Validated; Region: PRK09054 405955005427 6-phosphogluconate dehydratase; Region: edd; TIGR01196 405955005428 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 405955005429 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 405955005430 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 405955005431 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 405955005432 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 405955005433 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 405955005434 putative active site [active] 405955005435 pyruvate kinase; Provisional; Region: PRK05826 405955005436 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 405955005437 domain interfaces; other site 405955005438 active site 405955005439 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 405955005440 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 405955005441 putative acyl-acceptor binding pocket; other site 405955005442 putative peptidase; Provisional; Region: PRK11649 405955005443 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405955005444 Peptidase family M23; Region: Peptidase_M23; pfam01551 405955005445 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 405955005446 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 405955005447 metal binding site [ion binding]; metal-binding site 405955005448 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 405955005449 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 405955005450 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 405955005451 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955005452 ABC-ATPase subunit interface; other site 405955005453 dimer interface [polypeptide binding]; other site 405955005454 putative PBP binding regions; other site 405955005455 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 405955005456 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955005457 Walker A motif; other site 405955005458 ATP binding site [chemical binding]; other site 405955005459 Walker B motif; other site 405955005460 arginine finger; other site 405955005461 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 405955005462 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 405955005463 RuvA N terminal domain; Region: RuvA_N; pfam01330 405955005464 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 405955005465 hypothetical protein; Provisional; Region: PRK11470 405955005466 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 405955005467 active site 405955005468 putative DNA-binding cleft [nucleotide binding]; other site 405955005469 dimer interface [polypeptide binding]; other site 405955005470 hypothetical protein; Validated; Region: PRK00110 405955005471 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 405955005472 nudix motif; other site 405955005473 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 405955005474 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 405955005475 dimer interface [polypeptide binding]; other site 405955005476 anticodon binding site; other site 405955005477 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 405955005478 homodimer interface [polypeptide binding]; other site 405955005479 motif 1; other site 405955005480 active site 405955005481 motif 2; other site 405955005482 GAD domain; Region: GAD; pfam02938 405955005483 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 405955005484 motif 3; other site 405955005485 Isochorismatase family; Region: Isochorismatase; pfam00857 405955005486 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 405955005487 catalytic triad [active] 405955005488 conserved cis-peptide bond; other site 405955005489 hypothetical protein; Provisional; Region: PRK10302 405955005490 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 405955005491 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955005492 S-adenosylmethionine binding site [chemical binding]; other site 405955005493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955005494 S-adenosylmethionine binding site [chemical binding]; other site 405955005495 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 405955005496 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 405955005497 molybdopterin cofactor binding site [chemical binding]; other site 405955005498 substrate binding site [chemical binding]; other site 405955005499 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 405955005500 molybdopterin cofactor binding site; other site 405955005501 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 405955005502 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 405955005503 copper homeostasis protein CutC; Provisional; Region: PRK11572 405955005504 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 405955005505 putative metal binding site [ion binding]; other site 405955005506 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 405955005507 arginyl-tRNA synthetase; Region: argS; TIGR00456 405955005508 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 405955005509 active site 405955005510 HIGH motif; other site 405955005511 KMSK motif region; other site 405955005512 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 405955005513 tRNA binding surface [nucleotide binding]; other site 405955005514 anticodon binding site; other site 405955005515 Flagellar protein FlhE; Region: FlhE; pfam06366 405955005516 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 405955005517 FHIPEP family; Region: FHIPEP; pfam00771 405955005518 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 405955005519 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 405955005520 chemotaxis regulator CheZ; Provisional; Region: PRK11166 405955005521 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 405955005522 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955005523 active site 405955005524 phosphorylation site [posttranslational modification] 405955005525 intermolecular recognition site; other site 405955005526 dimerization interface [polypeptide binding]; other site 405955005527 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 405955005528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955005529 active site 405955005530 phosphorylation site [posttranslational modification] 405955005531 intermolecular recognition site; other site 405955005532 dimerization interface [polypeptide binding]; other site 405955005533 CheB methylesterase; Region: CheB_methylest; pfam01339 405955005534 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 405955005535 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 405955005536 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955005537 S-adenosylmethionine binding site [chemical binding]; other site 405955005538 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 405955005539 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 405955005540 dimer interface [polypeptide binding]; other site 405955005541 ligand binding site [chemical binding]; other site 405955005542 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405955005543 dimerization interface [polypeptide binding]; other site 405955005544 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405955005545 dimer interface [polypeptide binding]; other site 405955005546 putative CheW interface [polypeptide binding]; other site 405955005547 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 405955005548 putative CheA interaction surface; other site 405955005549 chemotaxis protein CheA; Provisional; Region: PRK10547 405955005550 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 405955005551 putative binding surface; other site 405955005552 active site 405955005553 CheY binding; Region: CheY-binding; pfam09078 405955005554 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 405955005555 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955005556 ATP binding site [chemical binding]; other site 405955005557 Mg2+ binding site [ion binding]; other site 405955005558 G-X-G motif; other site 405955005559 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 405955005560 flagellar motor protein MotB; Validated; Region: motB; PRK09041 405955005561 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 405955005562 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405955005563 ligand binding site [chemical binding]; other site 405955005564 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 405955005565 flagellar motor protein MotA; Validated; Region: PRK09110 405955005566 transcriptional activator FlhC; Provisional; Region: PRK12722 405955005567 transcriptional activator FlhD; Provisional; Region: PRK02909 405955005568 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405955005569 Ligand Binding Site [chemical binding]; other site 405955005570 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 405955005571 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 405955005572 active site 405955005573 homotetramer interface [polypeptide binding]; other site 405955005574 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 405955005575 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 405955005576 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405955005577 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405955005578 TM-ABC transporter signature motif; other site 405955005579 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 405955005580 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405955005581 Walker A/P-loop; other site 405955005582 ATP binding site [chemical binding]; other site 405955005583 Q-loop/lid; other site 405955005584 ABC transporter signature motif; other site 405955005585 Walker B; other site 405955005586 D-loop; other site 405955005587 H-loop/switch region; other site 405955005588 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405955005589 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 405955005590 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 405955005591 ligand binding site [chemical binding]; other site 405955005592 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 405955005593 Ferritin-like domain; Region: Ferritin; pfam00210 405955005594 ferroxidase diiron center [ion binding]; other site 405955005595 YecR-like lipoprotein; Region: YecR; pfam13992 405955005596 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 405955005597 Ferritin-like domain; Region: Ferritin; pfam00210 405955005598 ferroxidase diiron center [ion binding]; other site 405955005599 tyrosine transporter TyrP; Provisional; Region: PRK15132 405955005600 aromatic amino acid transport protein; Region: araaP; TIGR00837 405955005601 hypothetical protein; Provisional; Region: PRK10396 405955005602 yecA family protein; Region: ygfB_yecA; TIGR02292 405955005603 SEC-C motif; Region: SEC-C; pfam02810 405955005604 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 405955005605 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 405955005606 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 405955005607 GIY-YIG motif/motif A; other site 405955005608 active site 405955005609 catalytic site [active] 405955005610 putative DNA binding site [nucleotide binding]; other site 405955005611 metal binding site [ion binding]; metal-binding site 405955005612 UvrB/uvrC motif; Region: UVR; pfam02151 405955005613 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 405955005614 Helix-hairpin-helix motif; Region: HHH; pfam00633 405955005615 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955005616 response regulator; Provisional; Region: PRK09483 405955005617 active site 405955005618 phosphorylation site [posttranslational modification] 405955005619 intermolecular recognition site; other site 405955005620 dimerization interface [polypeptide binding]; other site 405955005621 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955005622 DNA binding residues [nucleotide binding] 405955005623 dimerization interface [polypeptide binding]; other site 405955005624 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 405955005625 Autoinducer binding domain; Region: Autoind_bind; pfam03472 405955005626 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955005627 DNA binding residues [nucleotide binding] 405955005628 dimerization interface [polypeptide binding]; other site 405955005629 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 405955005630 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405955005631 Walker A/P-loop; other site 405955005632 ATP binding site [chemical binding]; other site 405955005633 Q-loop/lid; other site 405955005634 ABC transporter signature motif; other site 405955005635 Walker B; other site 405955005636 D-loop; other site 405955005637 H-loop/switch region; other site 405955005638 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405955005639 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955005640 dimer interface [polypeptide binding]; other site 405955005641 conserved gate region; other site 405955005642 putative PBP binding loops; other site 405955005643 ABC-ATPase subunit interface; other site 405955005644 D-cysteine desulfhydrase; Validated; Region: PRK03910 405955005645 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 405955005646 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955005647 catalytic residue [active] 405955005648 cystine transporter subunit; Provisional; Region: PRK11260 405955005649 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955005650 substrate binding pocket [chemical binding]; other site 405955005651 membrane-bound complex binding site; other site 405955005652 hinge residues; other site 405955005653 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 405955005654 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 405955005655 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405955005656 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405955005657 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405955005658 DNA binding residues [nucleotide binding] 405955005659 flagellin; Validated; Region: PRK08026 405955005660 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 405955005661 Flagellin protein; Region: FliC; pfam12445 405955005662 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 405955005663 flagellar capping protein; Reviewed; Region: fliD; PRK08032 405955005664 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 405955005665 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 405955005666 Flagellar protein FliS; Region: FliS; cl00654 405955005667 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 405955005668 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 405955005669 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 405955005670 active site 405955005671 Na/Ca binding site [ion binding]; other site 405955005672 catalytic site [active] 405955005673 lipoprotein; Provisional; Region: PRK10397 405955005674 putative inner membrane protein; Provisional; Region: PRK11099 405955005675 hypothetical protein; Provisional; Region: PRK09951 405955005676 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 405955005677 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 405955005678 trimer interface [polypeptide binding]; other site 405955005679 eyelet of channel; other site 405955005680 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405955005681 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 405955005682 substrate binding site [chemical binding]; other site 405955005683 multidrug efflux protein; Reviewed; Region: emrE; PRK09541 405955005684 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 405955005685 flagellar MS-ring protein; Reviewed; Region: fliF; PRK06007 405955005686 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 405955005687 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 405955005688 flagellar motor switch protein FliG; Region: fliG; TIGR00207 405955005689 FliG C-terminal domain; Region: FliG_C; pfam01706 405955005690 flagellar assembly protein H; Validated; Region: fliH; PRK05687 405955005691 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 405955005692 Flagellar assembly protein FliH; Region: FliH; pfam02108 405955005693 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 405955005694 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 405955005695 Walker A motif/ATP binding site; other site 405955005696 Walker B motif; other site 405955005697 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 405955005698 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 405955005699 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 405955005700 flagellar hook-length control protein; Provisional; Region: PRK10118 405955005701 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 405955005702 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 405955005703 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 405955005704 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 405955005705 flagellar motor switch protein; Validated; Region: fliN; PRK05698 405955005706 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 405955005707 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 405955005708 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 405955005709 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 405955005710 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 405955005711 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955005712 DNA binding residues [nucleotide binding] 405955005713 dimerization interface [polypeptide binding]; other site 405955005714 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 405955005715 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955005716 active site 405955005717 motif I; other site 405955005718 motif II; other site 405955005719 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 405955005720 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955005721 metal binding site [ion binding]; metal-binding site 405955005722 active site 405955005723 I-site; other site 405955005724 hypothetical protein; Provisional; Region: PRK10062 405955005725 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 405955005726 EamA-like transporter family; Region: EamA; pfam00892 405955005727 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 405955005728 additional DNA contacts [nucleotide binding]; other site 405955005729 mismatch recognition site; other site 405955005730 active site 405955005731 zinc binding site [ion binding]; other site 405955005732 DNA intercalation site [nucleotide binding]; other site 405955005733 DNA cytosine methylase; Provisional; Region: PRK10458 405955005734 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 405955005735 cofactor binding site; other site 405955005736 DNA binding site [nucleotide binding] 405955005737 substrate interaction site [chemical binding]; other site 405955005738 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 405955005739 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405955005740 Zn2+ binding site [ion binding]; other site 405955005741 Mg2+ binding site [ion binding]; other site 405955005742 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 405955005743 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 405955005744 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 405955005745 eyelet of channel; other site 405955005746 trimer interface [polypeptide binding]; other site 405955005747 chaperone protein HchA; Provisional; Region: PRK04155 405955005748 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 405955005749 dimer interface [polypeptide binding]; other site 405955005750 metal binding site [ion binding]; metal-binding site 405955005751 potential oxyanion hole; other site 405955005752 potential catalytic triad [active] 405955005753 conserved cys residue [active] 405955005754 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 405955005755 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955005756 dimer interface [polypeptide binding]; other site 405955005757 phosphorylation site [posttranslational modification] 405955005758 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955005759 ATP binding site [chemical binding]; other site 405955005760 Mg2+ binding site [ion binding]; other site 405955005761 G-X-G motif; other site 405955005762 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 405955005763 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955005764 active site 405955005765 phosphorylation site [posttranslational modification] 405955005766 intermolecular recognition site; other site 405955005767 dimerization interface [polypeptide binding]; other site 405955005768 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955005769 DNA binding site [nucleotide binding] 405955005770 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 405955005771 active site 405955005772 homotetramer interface [polypeptide binding]; other site 405955005773 TMAO/DMSO reductase; Reviewed; Region: PRK05363 405955005774 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 405955005775 Moco binding site; other site 405955005776 metal coordination site [ion binding]; other site 405955005777 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 405955005778 YodA lipocalin-like domain; Region: YodA; cl01365 405955005779 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405955005780 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 405955005781 Concanavalin A-like lectin/glucanases superfamily; Region: Laminin_G_3; pfam13385 405955005782 Phage-related protein, tail component [Function unknown]; Region: COG4733 405955005783 Putative phage tail protein; Region: Phage-tail_3; pfam13550 405955005784 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 405955005785 Fibronectin type III protein; Region: DUF3672; pfam12421 405955005786 Phage-related protein, tail component [Function unknown]; Region: COG4723 405955005787 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 405955005788 MPN+ (JAMM) motif; other site 405955005789 Zinc-binding site [ion binding]; other site 405955005790 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405955005791 NlpC/P60 family; Region: NLPC_P60; cl17555 405955005792 Phage minor tail protein; Region: Phage_min_tail; pfam05939 405955005793 Phage-related minor tail protein [Function unknown]; Region: COG5281 405955005794 tape measure domain; Region: tape_meas_nterm; TIGR02675 405955005795 Tail length tape measure protein; Region: Phage_HK97_TLTM; pfam06120 405955005796 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 405955005797 Protein of unknown function (DUF4035); Region: DUF4035; pfam13227 405955005798 Phage tail assembly chaperone; Region: Phage_TAC; pfam06222 405955005799 Immunoglobulin domain; Region: Ig; cl11960 405955005800 Protein of unknown function (DUF3168); Region: DUF3168; pfam11367 405955005801 phage protein, HK97 gp10 family; Region: phge_HK97_gp10; TIGR01725 405955005802 Bacteriophage head-tail adaptor [General function prediction only]; Region: COG5614 405955005803 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 405955005804 oligomerization interface [polypeptide binding]; other site 405955005805 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 405955005806 Phage capsid family; Region: Phage_capsid; pfam05065 405955005807 Phage head maturation protease [General function prediction only]; Region: COG3740 405955005808 Phage portal protein; Region: Phage_portal; pfam04860 405955005809 Phage-related protein [Function unknown]; Region: COG4695 405955005810 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 405955005811 Phage terminase, small subunit; Region: Terminase_4; cl01525 405955005812 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 405955005813 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405955005814 active site 405955005815 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 405955005816 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 405955005817 catalytic residues [active] 405955005818 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 405955005819 Phage antitermination protein Q; Region: Phage_antiter_Q; pfam06323 405955005820 Holliday junction resolvase [DNA replication, recombination, and repair]; Region: Rus; COG4570 405955005821 Protein of unknown function (DUF968); Region: DUF968; pfam06147 405955005822 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 405955005823 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 405955005824 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955005825 non-specific DNA binding site [nucleotide binding]; other site 405955005826 salt bridge; other site 405955005827 transcriptional repressor DicA; Reviewed; Region: PRK09706 405955005828 sequence-specific DNA binding site [nucleotide binding]; other site 405955005829 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 405955005830 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 405955005831 active site 405955005832 catalytic site [active] 405955005833 substrate binding site [chemical binding]; other site 405955005834 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405955005835 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405955005836 active site 405955005837 DNA binding site [nucleotide binding] 405955005838 Int/Topo IB signature motif; other site 405955005839 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 405955005840 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 405955005841 active site 405955005842 Int/Topo IB signature motif; other site 405955005843 salicylate synthase Irp9; Reviewed; Region: PRK06772 405955005844 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 405955005845 muropeptide transporter; Validated; Region: ampG; cl17669 405955005846 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405955005847 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955005848 Walker A/P-loop; other site 405955005849 ATP binding site [chemical binding]; other site 405955005850 Q-loop/lid; other site 405955005851 ABC transporter signature motif; other site 405955005852 Walker B; other site 405955005853 D-loop; other site 405955005854 H-loop/switch region; other site 405955005855 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405955005856 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405955005857 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955005858 Walker A/P-loop; other site 405955005859 ATP binding site [chemical binding]; other site 405955005860 Q-loop/lid; other site 405955005861 ABC transporter signature motif; other site 405955005862 Walker B; other site 405955005863 D-loop; other site 405955005864 H-loop/switch region; other site 405955005865 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405955005866 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955005867 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 405955005868 Condensation domain; Region: Condensation; pfam00668 405955005869 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405955005870 Nonribosomal peptide synthase; Region: NRPS; pfam08415 405955005871 The adenylation domain of nonribosomal peptide synthetases (NRPS), including Streptoalloteichus tallysomycin biosynthesis genes; Region: A_NRPS_TlmIV_like; cd12114 405955005872 acyl-activating enzyme (AAE) consensus motif; other site 405955005873 AMP binding site [chemical binding]; other site 405955005874 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955005875 S-adenosylmethionine binding site [chemical binding]; other site 405955005876 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 405955005877 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405955005878 Condensation domain; Region: Condensation; pfam00668 405955005879 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405955005880 Nonribosomal peptide synthase; Region: NRPS; pfam08415 405955005881 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405955005882 polyketide synthases (PKSs) polymerize simple fatty acids into a large variety of different products, called polyketides, by successive decarboxylating Claisen condensations. PKSs can be divided into 2 groups, modular type I PKSs consisting of one or...; Region: PKS; cd00833 405955005883 Beta-ketoacyl synthase; Region: PKS_KS; smart00825 405955005884 active site 405955005885 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 405955005886 Acyl transferase domain in polyketide synthase (PKS) enzymes; Region: PKS_AT; smart00827 405955005887 Methyltransferase domain; Region: Methyltransf_12; pfam08242 405955005888 ketoreductase (KR) and fatty acid synthase (FAS), complex (x) SDRs; Region: KR_FAS_SDR_x; cd05274 405955005889 KR domain; Region: KR; pfam08659 405955005890 NADP binding site [chemical binding]; other site 405955005891 active site 405955005892 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405955005893 Condensation domain; Region: Condensation; pfam00668 405955005894 Non-ribosomal peptide synthetase modules and related proteins [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntF; COG1020 405955005895 Nonribosomal peptide synthase; Region: NRPS; pfam08415 405955005896 Methyltransferase domain; Region: Methyltransf_12; pfam08242 405955005897 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 405955005898 Thioesterase domains of type I polyketide synthases or non-ribosomal peptide synthetases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3319 405955005899 Oxidoreductase (NAD-binding), involved in siderophore biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: PchG; COG4693 405955005900 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405955005901 Predicted thioesterase involved in non-ribosomal peptide biosynthesis [Secondary metabolites biosynthesis, transport, and catabolism]; Region: GrsT; COG3208 405955005902 Peptide arylation enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: EntE; COG1021 405955005903 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 405955005904 acyl-activating enzyme (AAE) consensus motif; other site 405955005905 active site 405955005906 AMP binding site [chemical binding]; other site 405955005907 substrate binding site [chemical binding]; other site 405955005908 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 405955005909 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 405955005910 N-terminal plug; other site 405955005911 ligand-binding site [chemical binding]; other site 405955005912 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 405955005913 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 405955005914 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 405955005915 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 405955005916 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 405955005917 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 405955005918 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 405955005919 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 405955005920 shikimate transporter; Provisional; Region: PRK09952 405955005921 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955005922 putative substrate translocation pore; other site 405955005923 AMP nucleosidase; Provisional; Region: PRK08292 405955005924 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 405955005925 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 405955005926 hypothetical protein; Provisional; Region: PRK12378 405955005927 MATE family multidrug exporter; Provisional; Region: PRK10189 405955005928 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 405955005929 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 405955005930 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955005931 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 405955005932 putative substrate binding site [chemical binding]; other site 405955005933 dimerization interface [polypeptide binding]; other site 405955005934 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 405955005935 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955005936 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 405955005937 putative dimerization interface [polypeptide binding]; other site 405955005938 L,D-transpeptidase; Provisional; Region: PRK10190 405955005939 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 405955005940 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 405955005941 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 405955005942 putative dimer interface [polypeptide binding]; other site 405955005943 active site pocket [active] 405955005944 putative cataytic base [active] 405955005945 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 405955005946 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 405955005947 homotrimer interface [polypeptide binding]; other site 405955005948 Walker A motif; other site 405955005949 GTP binding site [chemical binding]; other site 405955005950 Walker B motif; other site 405955005951 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405955005952 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 405955005953 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405955005954 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 405955005955 substrate binding site [chemical binding]; other site 405955005956 dimer interface [polypeptide binding]; other site 405955005957 ATP binding site [chemical binding]; other site 405955005958 A4 beta-galactosidase middle domain: a type 1 glutamine amidotransferase (GATase1)-like domain; Region: A4_beta-galactosidase_middle_domain; cd03143 405955005959 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 405955005960 Protein of unknown function, DUF606; Region: DUF606; pfam04657 405955005961 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 405955005962 active site 405955005963 substrate binding pocket [chemical binding]; other site 405955005964 homodimer interaction site [polypeptide binding]; other site 405955005965 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3464 405955005966 Transposase; Region: DDE_Tnp_ISL3; pfam01610 405955005967 Helix-turn-helix domain of transposase family ISL3; Region: HTH_Tnp_ISL3; pfam13542 405955005968 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 405955005969 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 405955005970 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 405955005971 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 405955005972 putative transposase OrfB; Reviewed; Region: PHA02517 405955005973 HTH-like domain; Region: HTH_21; pfam13276 405955005974 Integrase core domain; Region: rve; pfam00665 405955005975 Integrase core domain; Region: rve_2; pfam13333 405955005976 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405955005977 Helix-turn-helix domain; Region: HTH_28; pfam13518 405955005978 Helix-turn-helix domain; Region: HTH_28; pfam13518 405955005979 Predicted GTPase [General function prediction only]; Region: COG3596 405955005980 YfjP GTPase; Region: YfjP; cd11383 405955005981 G1 box; other site 405955005982 GTP/Mg2+ binding site [chemical binding]; other site 405955005983 Switch I region; other site 405955005984 G2 box; other site 405955005985 Switch II region; other site 405955005986 G3 box; other site 405955005987 G4 box; other site 405955005988 G5 box; other site 405955005989 hypothetical protein; Provisional; Region: PRK09866 405955005990 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 405955005991 G1 box; other site 405955005992 GTP/Mg2+ binding site [chemical binding]; other site 405955005993 G2 box; other site 405955005994 Switch I region; other site 405955005995 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 405955005996 G3 box; other site 405955005997 Switch II region; other site 405955005998 GTP/Mg2+ binding site [chemical binding]; other site 405955005999 G4 box; other site 405955006000 G5 box; other site 405955006001 YjcZ-like protein; Region: YjcZ; pfam13990 405955006002 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: RssA; COG1752 405955006003 Patatins and Phospholipases; Region: Patatin_and_cPLA2; cl11396 405955006004 nucleophile elbow; other site 405955006005 Hypothetical patatin similar to Z1214 protein of Escherichia coli; Region: Pat_hypo_Ecoli_Z1214_like; cd07209 405955006006 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 405955006007 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 405955006008 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 405955006009 Switch II region; other site 405955006010 G4 box; other site 405955006011 G5 box; other site 405955006012 hypothetical protein; Provisional; Region: PRK05423 405955006013 Predicted membrane protein [Function unknown]; Region: COG1289 405955006014 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 405955006015 DNA gyrase inhibitor; Provisional; Region: PRK10016 405955006016 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405955006017 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 405955006018 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 405955006019 exonuclease I; Provisional; Region: sbcB; PRK11779 405955006020 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 405955006021 active site 405955006022 catalytic site [active] 405955006023 substrate binding site [chemical binding]; other site 405955006024 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 405955006025 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 405955006026 Sulphur transport; Region: Sulf_transp; pfam04143 405955006027 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 405955006028 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955006029 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 405955006030 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 405955006031 dimerization interface [polypeptide binding]; other site 405955006032 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405955006033 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 405955006034 putative NAD(P) binding site [chemical binding]; other site 405955006035 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 405955006036 antitoxin YefM; Provisional; Region: PRK11409 405955006037 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 405955006038 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 405955006039 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 405955006040 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 405955006041 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 405955006042 NAD binding site [chemical binding]; other site 405955006043 dimerization interface [polypeptide binding]; other site 405955006044 product binding site; other site 405955006045 substrate binding site [chemical binding]; other site 405955006046 zinc binding site [ion binding]; other site 405955006047 catalytic residues [active] 405955006048 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 405955006049 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405955006050 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955006051 homodimer interface [polypeptide binding]; other site 405955006052 catalytic residue [active] 405955006053 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 405955006054 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955006055 active site 405955006056 motif I; other site 405955006057 motif II; other site 405955006058 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 405955006059 putative active site pocket [active] 405955006060 4-fold oligomerization interface [polypeptide binding]; other site 405955006061 metal binding residues [ion binding]; metal-binding site 405955006062 3-fold/trimer interface [polypeptide binding]; other site 405955006063 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 405955006064 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 405955006065 putative active site [active] 405955006066 oxyanion strand; other site 405955006067 catalytic triad [active] 405955006068 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 405955006069 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 405955006070 catalytic residues [active] 405955006071 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 405955006072 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 405955006073 substrate binding site [chemical binding]; other site 405955006074 glutamase interaction surface [polypeptide binding]; other site 405955006075 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 405955006076 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 405955006077 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 405955006078 metal binding site [ion binding]; metal-binding site 405955006079 chain length determinant protein WzzB; Provisional; Region: PRK15471 405955006080 Chain length determinant protein; Region: Wzz; pfam02706 405955006081 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 405955006082 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 405955006083 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 405955006084 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 405955006085 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405955006086 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 405955006087 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 405955006088 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405955006089 Wzx, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_Wzx_like; cd13128 405955006090 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 405955006091 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 405955006092 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 405955006093 substrate binding site; other site 405955006094 tetramer interface; other site 405955006095 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 405955006096 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 405955006097 NADP binding site [chemical binding]; other site 405955006098 active site 405955006099 putative substrate binding site [chemical binding]; other site 405955006100 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 405955006101 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 405955006102 NAD binding site [chemical binding]; other site 405955006103 substrate binding site [chemical binding]; other site 405955006104 homodimer interface [polypeptide binding]; other site 405955006105 active site 405955006106 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 405955006107 active site 405955006108 tetramer interface; other site 405955006109 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 405955006110 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 405955006111 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 405955006112 putative ADP-binding pocket [chemical binding]; other site 405955006113 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 405955006114 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 405955006115 colanic acid exporter; Provisional; Region: PRK10459 405955006116 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 405955006117 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 405955006118 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 405955006119 phosphomannomutase CpsG; Provisional; Region: PRK15414 405955006120 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 405955006121 active site 405955006122 substrate binding site [chemical binding]; other site 405955006123 metal binding site [ion binding]; metal-binding site 405955006124 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 405955006125 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 405955006126 Substrate binding site; other site 405955006127 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 405955006128 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 405955006129 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 405955006130 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 405955006131 active site 405955006132 GDP-Mannose binding site [chemical binding]; other site 405955006133 dimer interface [polypeptide binding]; other site 405955006134 modified nudix motif 405955006135 metal binding site [ion binding]; metal-binding site 405955006136 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 405955006137 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 405955006138 NADP binding site [chemical binding]; other site 405955006139 active site 405955006140 putative substrate binding site [chemical binding]; other site 405955006141 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 405955006142 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 405955006143 NADP-binding site; other site 405955006144 homotetramer interface [polypeptide binding]; other site 405955006145 substrate binding site [chemical binding]; other site 405955006146 homodimer interface [polypeptide binding]; other site 405955006147 active site 405955006148 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 405955006149 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 405955006150 putative trimer interface [polypeptide binding]; other site 405955006151 putative active site [active] 405955006152 putative substrate binding site [chemical binding]; other site 405955006153 putative CoA binding site [chemical binding]; other site 405955006154 putative glycosyl transferase; Provisional; Region: PRK10063 405955006155 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 405955006156 metal-binding site 405955006157 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 405955006158 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 405955006159 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 405955006160 putative acyl transferase; Provisional; Region: PRK10191 405955006161 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 405955006162 trimer interface [polypeptide binding]; other site 405955006163 active site 405955006164 substrate binding site [chemical binding]; other site 405955006165 CoA binding site [chemical binding]; other site 405955006166 putative glycosyl transferase; Provisional; Region: PRK10018 405955006167 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 405955006168 active site 405955006169 tyrosine kinase; Provisional; Region: PRK11519 405955006170 Chain length determinant protein; Region: Wzz; pfam02706 405955006171 Chain length determinant protein; Region: Wzz; cl15801 405955006172 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 405955006173 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405955006174 Low molecular weight phosphatase family; Region: LMWPc; cd00115 405955006175 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 405955006176 active site 405955006177 polysaccharide export protein Wza; Provisional; Region: PRK15078 405955006178 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 405955006179 SLBB domain; Region: SLBB; pfam10531 405955006180 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 405955006181 FOG: CBS domain [General function prediction only]; Region: COG0517 405955006182 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405955006183 Transporter associated domain; Region: CorC_HlyC; smart01091 405955006184 Phage-related protein [Function unknown]; Region: COG4679 405955006185 putative assembly protein; Provisional; Region: PRK10833 405955006186 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 405955006187 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 405955006188 trimer interface [polypeptide binding]; other site 405955006189 active site 405955006190 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 405955006191 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 405955006192 ATP-binding site [chemical binding]; other site 405955006193 Sugar specificity; other site 405955006194 Pyrimidine base specificity; other site 405955006195 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 405955006196 putative diguanylate cyclase; Provisional; Region: PRK09776 405955006197 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405955006198 putative active site [active] 405955006199 heme pocket [chemical binding]; other site 405955006200 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405955006201 putative active site [active] 405955006202 heme pocket [chemical binding]; other site 405955006203 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405955006204 putative active site [active] 405955006205 heme pocket [chemical binding]; other site 405955006206 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955006207 metal binding site [ion binding]; metal-binding site 405955006208 active site 405955006209 I-site; other site 405955006210 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cl00290 405955006211 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 405955006212 AlkA N-terminal domain; Region: AlkA_N; smart01009 405955006213 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405955006214 minor groove reading motif; other site 405955006215 helix-hairpin-helix signature motif; other site 405955006216 substrate binding pocket [chemical binding]; other site 405955006217 active site 405955006218 putative chaperone; Provisional; Region: PRK11678 405955006219 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 405955006220 nucleotide binding site [chemical binding]; other site 405955006221 putative NEF/HSP70 interaction site [polypeptide binding]; other site 405955006222 SBD interface [polypeptide binding]; other site 405955006223 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 405955006224 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 405955006225 substrate binding site [chemical binding]; other site 405955006226 activation loop (A-loop); other site 405955006227 Y-family of DNA polymerases; Region: PolY; cl12025 405955006228 Protein phosphatase 2C; Region: PP2C_2; pfam13672 405955006229 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 405955006230 metal ion-dependent adhesion site (MIDAS); other site 405955006231 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 405955006232 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955006233 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955006234 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405955006235 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 405955006236 Protein export membrane protein; Region: SecD_SecF; cl14618 405955006237 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 405955006238 putative transporter; Provisional; Region: PRK10504 405955006239 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955006240 putative substrate translocation pore; other site 405955006241 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 405955006242 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405955006243 dimerization interface [polypeptide binding]; other site 405955006244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955006245 dimer interface [polypeptide binding]; other site 405955006246 phosphorylation site [posttranslational modification] 405955006247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955006248 ATP binding site [chemical binding]; other site 405955006249 Mg2+ binding site [ion binding]; other site 405955006250 G-X-G motif; other site 405955006251 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 405955006252 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955006253 active site 405955006254 phosphorylation site [posttranslational modification] 405955006255 intermolecular recognition site; other site 405955006256 dimerization interface [polypeptide binding]; other site 405955006257 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955006258 DNA binding site [nucleotide binding] 405955006259 Uncharacterized conserved protein [Function unknown]; Region: COG3422 405955006260 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 405955006261 Domain of unknown function (DUF4034); Region: DUF4034; pfam13226 405955006262 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 405955006263 PcfJ-like protein; Region: PcfJ; pfam14284 405955006264 putative protease; Provisional; Region: PRK15452 405955006265 Peptidase family U32; Region: Peptidase_U32; pfam01136 405955006266 tail protein; Provisional; Region: D; PHA02561 405955006267 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 405955006268 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 405955006269 terminase ATPase subunit; Provisional; Region: P; PHA02535 405955006270 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 405955006271 portal vertex protein; Provisional; Region: Q; PHA02536 405955006272 Phage portal protein; Region: Phage_portal; pfam04860 405955006273 DNA recombination-mediator protein A; Region: DNA_processg_A; pfam02481 405955006274 DNA protecting protein DprA; Region: dprA; TIGR00732 405955006275 Predicted phosphatases [General function prediction only]; Region: Gph; COG0546 405955006276 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cl17915 405955006277 motif II; other site 405955006278 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405955006279 active site 405955006280 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 405955006281 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405955006282 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955006283 non-specific DNA binding site [nucleotide binding]; other site 405955006284 salt bridge; other site 405955006285 sequence-specific DNA binding site [nucleotide binding]; other site 405955006286 integrase; Provisional; Region: int; PHA02601 405955006287 Phage HP1 integrase, C-terminal catalytic domain. Bacteriophage HP1 and related integrases are found in eubacteria, plasmids and temperate bacteriophages of the P2 family. They belong to the DNA breaking-rejoining enzyme superfamily, which includes...; Region: HP1_INT_C; cd00797 405955006288 dimer interface [polypeptide binding]; other site 405955006289 active site 405955006290 catalytic residues [active] 405955006291 Int/Topo IB signature motif; other site 405955006292 lipid kinase; Reviewed; Region: PRK13054 405955006293 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 405955006294 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405955006295 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 405955006296 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405955006297 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 405955006298 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 405955006299 putative NAD(P) binding site [chemical binding]; other site 405955006300 catalytic Zn binding site [ion binding]; other site 405955006301 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 405955006302 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 405955006303 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 405955006304 active site 405955006305 P-loop; other site 405955006306 phosphorylation site [posttranslational modification] 405955006307 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405955006308 active site 405955006309 phosphorylation site [posttranslational modification] 405955006310 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 405955006311 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 405955006312 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 405955006313 intersubunit interface [polypeptide binding]; other site 405955006314 active site 405955006315 zinc binding site [ion binding]; other site 405955006316 Na+ binding site [ion binding]; other site 405955006317 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 405955006318 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 405955006319 putative active site; other site 405955006320 catalytic residue [active] 405955006321 nucleoside transporter; Region: 2A0110; TIGR00889 405955006322 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955006323 putative substrate translocation pore; other site 405955006324 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 405955006325 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405955006326 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 405955006327 substrate binding site [chemical binding]; other site 405955006328 ATP binding site [chemical binding]; other site 405955006329 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405955006330 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955006331 DNA-binding site [nucleotide binding]; DNA binding site 405955006332 UTRA domain; Region: UTRA; pfam07702 405955006333 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 405955006334 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 405955006335 active site 405955006336 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 405955006337 dimer interface [polypeptide binding]; other site 405955006338 substrate binding site [chemical binding]; other site 405955006339 ATP binding site [chemical binding]; other site 405955006340 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 405955006341 substrate binding site [chemical binding]; other site 405955006342 multimerization interface [polypeptide binding]; other site 405955006343 ATP binding site [chemical binding]; other site 405955006344 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 405955006345 Predicted integral membrane protein [Function unknown]; Region: COG5455 405955006346 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 405955006347 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 405955006348 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 405955006349 PapC N-terminal domain; Region: PapC_N; pfam13954 405955006350 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 405955006351 PapC C-terminal domain; Region: PapC_C; pfam13953 405955006352 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 405955006353 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 405955006354 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 405955006355 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 405955006356 antiporter inner membrane protein; Provisional; Region: PRK11670 405955006357 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 405955006358 Walker A motif; other site 405955006359 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 405955006360 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 405955006361 active site 405955006362 HIGH motif; other site 405955006363 KMSKS motif; other site 405955006364 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 405955006365 tRNA binding surface [nucleotide binding]; other site 405955006366 anticodon binding site; other site 405955006367 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 405955006368 dimer interface [polypeptide binding]; other site 405955006369 putative tRNA-binding site [nucleotide binding]; other site 405955006370 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 405955006371 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 405955006372 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 405955006373 MoxR-like ATPases [General function prediction only]; Region: COG0714 405955006374 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 405955006375 Walker A motif; other site 405955006376 ATP binding site [chemical binding]; other site 405955006377 Walker B motif; other site 405955006378 arginine finger; other site 405955006379 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 405955006380 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 405955006381 metal ion-dependent adhesion site (MIDAS); other site 405955006382 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 405955006383 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 405955006384 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 405955006385 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 405955006386 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 405955006387 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955006388 active site 405955006389 phosphorylation site [posttranslational modification] 405955006390 intermolecular recognition site; other site 405955006391 dimerization interface [polypeptide binding]; other site 405955006392 LytTr DNA-binding domain; Region: LytTR; pfam04397 405955006393 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 405955006394 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405955006395 GAF domain; Region: GAF; pfam01590 405955006396 Histidine kinase; Region: His_kinase; pfam06580 405955006397 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955006398 ATP binding site [chemical binding]; other site 405955006399 Mg2+ binding site [ion binding]; other site 405955006400 G-X-G motif; other site 405955006401 transcriptional regulator MirA; Provisional; Region: PRK15043 405955006402 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 405955006403 DNA binding residues [nucleotide binding] 405955006404 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 405955006405 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955006406 dimer interface [polypeptide binding]; other site 405955006407 conserved gate region; other site 405955006408 putative PBP binding loops; other site 405955006409 ABC-ATPase subunit interface; other site 405955006410 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 405955006411 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 405955006412 Walker A/P-loop; other site 405955006413 ATP binding site [chemical binding]; other site 405955006414 Q-loop/lid; other site 405955006415 ABC transporter signature motif; other site 405955006416 Walker B; other site 405955006417 D-loop; other site 405955006418 H-loop/switch region; other site 405955006419 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 405955006420 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955006421 dimer interface [polypeptide binding]; other site 405955006422 conserved gate region; other site 405955006423 ABC-ATPase subunit interface; other site 405955006424 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 405955006425 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 405955006426 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 405955006427 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 405955006428 D-lactate dehydrogenase; Provisional; Region: PRK11183 405955006429 FAD binding domain; Region: FAD_binding_4; pfam01565 405955006430 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 405955006431 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 405955006432 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 405955006433 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 405955006434 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405955006435 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 405955006436 oxidoreductase; Provisional; Region: PRK12743 405955006437 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405955006438 NAD(P) binding site [chemical binding]; other site 405955006439 active site 405955006440 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 405955006441 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 405955006442 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 405955006443 FMN binding site [chemical binding]; other site 405955006444 active site 405955006445 catalytic residues [active] 405955006446 substrate binding site [chemical binding]; other site 405955006447 hypothetical protein; Provisional; Region: PRK01821 405955006448 hypothetical protein; Provisional; Region: PRK10711 405955006449 cytidine deaminase; Provisional; Region: PRK09027 405955006450 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405955006451 active site 405955006452 catalytic motif [active] 405955006453 Zn binding site [ion binding]; other site 405955006454 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 405955006455 active site 405955006456 catalytic motif [active] 405955006457 Zn binding site [ion binding]; other site 405955006458 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405955006459 putative active site [active] 405955006460 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 405955006461 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405955006462 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955006463 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 405955006464 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 405955006465 homodimer interface [polypeptide binding]; other site 405955006466 active site 405955006467 FMN binding site [chemical binding]; other site 405955006468 substrate binding site [chemical binding]; other site 405955006469 4Fe-4S binding domain; Region: Fer4; pfam00037 405955006470 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405955006471 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405955006472 TM-ABC transporter signature motif; other site 405955006473 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405955006474 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 405955006475 Walker A/P-loop; other site 405955006476 ATP binding site [chemical binding]; other site 405955006477 Q-loop/lid; other site 405955006478 ABC transporter signature motif; other site 405955006479 Walker B; other site 405955006480 D-loop; other site 405955006481 H-loop/switch region; other site 405955006482 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405955006483 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 405955006484 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 405955006485 ligand binding site [chemical binding]; other site 405955006486 calcium binding site [ion binding]; other site 405955006487 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 405955006488 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955006489 DNA binding site [nucleotide binding] 405955006490 domain linker motif; other site 405955006491 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 405955006492 dimerization interface (closed form) [polypeptide binding]; other site 405955006493 ligand binding site [chemical binding]; other site 405955006494 Predicted membrane protein [Function unknown]; Region: COG2311 405955006495 hypothetical protein; Provisional; Region: PRK10835 405955006496 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 405955006497 homodecamer interface [polypeptide binding]; other site 405955006498 GTP cyclohydrolase I; Provisional; Region: PLN03044 405955006499 active site 405955006500 putative catalytic site residues [active] 405955006501 zinc binding site [ion binding]; other site 405955006502 GTP-CH-I/GFRP interaction surface; other site 405955006503 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 405955006504 S-formylglutathione hydrolase; Region: PLN02442 405955006505 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 405955006506 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 405955006507 N-terminal plug; other site 405955006508 ligand-binding site [chemical binding]; other site 405955006509 lysine transporter; Provisional; Region: PRK10836 405955006510 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 405955006511 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955006512 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 405955006513 putative dimerization interface [polypeptide binding]; other site 405955006514 endonuclease IV; Provisional; Region: PRK01060 405955006515 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 405955006516 AP (apurinic/apyrimidinic) site pocket; other site 405955006517 DNA interaction; other site 405955006518 Metal-binding active site; metal-binding site 405955006519 putative kinase; Provisional; Region: PRK09954 405955006520 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405955006521 putative DNA binding site [nucleotide binding]; other site 405955006522 putative Zn2+ binding site [ion binding]; other site 405955006523 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 405955006524 substrate binding site [chemical binding]; other site 405955006525 ATP binding site [chemical binding]; other site 405955006526 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 405955006527 active site 405955006528 tetramer interface [polypeptide binding]; other site 405955006529 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 405955006530 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405955006531 ligand binding site [chemical binding]; other site 405955006532 flexible hinge region; other site 405955006533 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 405955006534 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405955006535 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405955006536 Nucleoside recognition; Region: Gate; pfam07670 405955006537 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405955006538 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 405955006539 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 405955006540 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405955006541 substrate binding site [chemical binding]; other site 405955006542 ATP binding site [chemical binding]; other site 405955006543 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 405955006544 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 405955006545 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 405955006546 active site 405955006547 P-loop; other site 405955006548 phosphorylation site [posttranslational modification] 405955006549 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 405955006550 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 405955006551 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 405955006552 putative substrate binding site [chemical binding]; other site 405955006553 putative ATP binding site [chemical binding]; other site 405955006554 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 405955006555 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405955006556 active site 405955006557 phosphorylation site [posttranslational modification] 405955006558 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405955006559 dimerization domain swap beta strand [polypeptide binding]; other site 405955006560 regulatory protein interface [polypeptide binding]; other site 405955006561 active site 405955006562 regulatory phosphorylation site [posttranslational modification]; other site 405955006563 sugar efflux transporter B; Provisional; Region: PRK15011 405955006564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955006565 putative substrate translocation pore; other site 405955006566 elongation factor P; Provisional; Region: PRK04542 405955006567 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 405955006568 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 405955006569 RNA binding site [nucleotide binding]; other site 405955006570 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 405955006571 RNA binding site [nucleotide binding]; other site 405955006572 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 405955006573 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 405955006574 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 405955006575 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 405955006576 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 405955006577 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 405955006578 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 405955006579 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 405955006580 active site 405955006581 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 405955006582 NlpC/P60 family; Region: NLPC_P60; pfam00877 405955006583 phage resistance protein; Provisional; Region: PRK10551 405955006584 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 405955006585 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955006586 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 405955006587 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 405955006588 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 405955006589 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955006590 dimer interface [polypeptide binding]; other site 405955006591 conserved gate region; other site 405955006592 putative PBP binding loops; other site 405955006593 ABC-ATPase subunit interface; other site 405955006594 microcin C ABC transporter permease; Provisional; Region: PRK15021 405955006595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955006596 dimer interface [polypeptide binding]; other site 405955006597 conserved gate region; other site 405955006598 ABC-ATPase subunit interface; other site 405955006599 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 405955006600 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955006601 Walker A/P-loop; other site 405955006602 ATP binding site [chemical binding]; other site 405955006603 Q-loop/lid; other site 405955006604 ABC transporter signature motif; other site 405955006605 Walker B; other site 405955006606 D-loop; other site 405955006607 H-loop/switch region; other site 405955006608 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405955006609 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955006610 Walker A/P-loop; other site 405955006611 ATP binding site [chemical binding]; other site 405955006612 Q-loop/lid; other site 405955006613 ABC transporter signature motif; other site 405955006614 Walker B; other site 405955006615 D-loop; other site 405955006616 H-loop/switch region; other site 405955006617 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 405955006618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955006619 putative substrate translocation pore; other site 405955006620 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 405955006621 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405955006622 RNA binding surface [nucleotide binding]; other site 405955006623 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 405955006624 active site 405955006625 uracil binding [chemical binding]; other site 405955006626 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 405955006627 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405955006628 ATP binding site [chemical binding]; other site 405955006629 putative Mg++ binding site [ion binding]; other site 405955006630 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405955006631 nucleotide binding region [chemical binding]; other site 405955006632 ATP-binding site [chemical binding]; other site 405955006633 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 405955006634 Nucleoid-associated protein [General function prediction only]; Region: COG3081 405955006635 nucleoid-associated protein NdpA; Validated; Region: PRK00378 405955006636 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 405955006637 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 405955006638 Sulfatase; Region: Sulfatase; pfam00884 405955006639 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cl00185 405955006640 transcriptional regulator NarP; Provisional; Region: PRK10403 405955006641 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955006642 active site 405955006643 phosphorylation site [posttranslational modification] 405955006644 intermolecular recognition site; other site 405955006645 dimerization interface [polypeptide binding]; other site 405955006646 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955006647 DNA binding residues [nucleotide binding] 405955006648 dimerization interface [polypeptide binding]; other site 405955006649 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 405955006650 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 405955006651 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405955006652 binding surface 405955006653 TPR motif; other site 405955006654 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 405955006655 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 405955006656 catalytic residues [active] 405955006657 central insert; other site 405955006658 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 405955006659 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 405955006660 heme exporter protein CcmC; Region: ccmC; TIGR01191 405955006661 heme exporter protein CcmB; Region: ccmB; TIGR01190 405955006662 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 405955006663 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 405955006664 Walker A/P-loop; other site 405955006665 ATP binding site [chemical binding]; other site 405955006666 Q-loop/lid; other site 405955006667 ABC transporter signature motif; other site 405955006668 Walker B; other site 405955006669 D-loop; other site 405955006670 H-loop/switch region; other site 405955006671 cytochrome c-type protein NapC; Provisional; Region: PRK10617 405955006672 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 405955006673 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 405955006674 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 405955006675 4Fe-4S binding domain; Region: Fer4_5; pfam12801 405955006676 4Fe-4S binding domain; Region: Fer4_6; pfam12837 405955006677 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 405955006678 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 405955006679 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 405955006680 [4Fe-4S] binding site [ion binding]; other site 405955006681 molybdopterin cofactor binding site; other site 405955006682 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 405955006683 molybdopterin cofactor binding site; other site 405955006684 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 405955006685 ferredoxin-type protein; Provisional; Region: PRK10194 405955006686 malate:quinone oxidoreductase; Validated; Region: PRK05257 405955006687 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 405955006688 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 405955006689 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 405955006690 Walker A/P-loop; other site 405955006691 ATP binding site [chemical binding]; other site 405955006692 Q-loop/lid; other site 405955006693 ABC transporter signature motif; other site 405955006694 Walker B; other site 405955006695 D-loop; other site 405955006696 H-loop/switch region; other site 405955006697 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 405955006698 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 405955006699 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 405955006700 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955006701 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 405955006702 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 405955006703 DNA binding site [nucleotide binding] 405955006704 active site 405955006705 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 405955006706 ApbE family; Region: ApbE; pfam02424 405955006707 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 405955006708 outer membrane porin protein C; Provisional; Region: PRK10554 405955006709 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 405955006710 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955006711 ATP binding site [chemical binding]; other site 405955006712 G-X-G motif; other site 405955006713 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 405955006714 putative binding surface; other site 405955006715 active site 405955006716 transcriptional regulator RcsB; Provisional; Region: PRK10840 405955006717 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955006718 active site 405955006719 phosphorylation site [posttranslational modification] 405955006720 intermolecular recognition site; other site 405955006721 dimerization interface [polypeptide binding]; other site 405955006722 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955006723 DNA binding residues [nucleotide binding] 405955006724 dimerization interface [polypeptide binding]; other site 405955006725 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 405955006726 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955006727 dimer interface [polypeptide binding]; other site 405955006728 phosphorylation site [posttranslational modification] 405955006729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955006730 ATP binding site [chemical binding]; other site 405955006731 Mg2+ binding site [ion binding]; other site 405955006732 G-X-G motif; other site 405955006733 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 405955006734 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955006735 active site 405955006736 phosphorylation site [posttranslational modification] 405955006737 intermolecular recognition site; other site 405955006738 dimerization interface [polypeptide binding]; other site 405955006739 sensory histidine kinase AtoS; Provisional; Region: PRK11360 405955006740 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405955006741 putative active site [active] 405955006742 heme pocket [chemical binding]; other site 405955006743 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955006744 dimer interface [polypeptide binding]; other site 405955006745 phosphorylation site [posttranslational modification] 405955006746 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955006747 ATP binding site [chemical binding]; other site 405955006748 Mg2+ binding site [ion binding]; other site 405955006749 G-X-G motif; other site 405955006750 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 405955006751 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955006752 active site 405955006753 phosphorylation site [posttranslational modification] 405955006754 intermolecular recognition site; other site 405955006755 dimerization interface [polypeptide binding]; other site 405955006756 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955006757 Walker A motif; other site 405955006758 ATP binding site [chemical binding]; other site 405955006759 Walker B motif; other site 405955006760 arginine finger; other site 405955006761 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405955006762 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 405955006763 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 405955006764 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 405955006765 Condensing enzymes; Family of enzymes that catalyze a (decarboxylating or non-decarboxylating) Claisen-like condensation reaction. Members are share strong structural similarity, and are involved in the synthesis and degradation of fatty acids, and the...; Region: cond_enzymes; cl09938 405955006766 active site 405955006767 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405955006768 active site 405955006769 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 405955006770 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 405955006771 Predicted secreted protein [Function unknown]; Region: COG5445 405955006772 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 405955006773 Predicted secreted protein [Function unknown]; Region: COG5445 405955006774 Stage II sporulation protein; Region: SpoIID; pfam08486 405955006775 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 405955006776 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 405955006777 MG2 domain; Region: A2M_N; pfam01835 405955006778 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 405955006779 Alpha-2-macroglobulin family; Region: A2M; pfam00207 405955006780 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 405955006781 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 405955006782 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 405955006783 DNA gyrase subunit A; Validated; Region: PRK05560 405955006784 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 405955006785 CAP-like domain; other site 405955006786 active site 405955006787 primary dimer interface [polypeptide binding]; other site 405955006788 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405955006789 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405955006790 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405955006791 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405955006792 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405955006793 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405955006794 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 405955006795 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955006796 S-adenosylmethionine binding site [chemical binding]; other site 405955006797 adhesin; Provisional; Region: PRK09752 405955006798 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 405955006799 Autotransporter beta-domain; Region: Autotransporter; pfam03797 405955006800 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 405955006801 ATP cone domain; Region: ATP-cone; pfam03477 405955006802 Class I ribonucleotide reductase; Region: RNR_I; cd01679 405955006803 active site 405955006804 dimer interface [polypeptide binding]; other site 405955006805 catalytic residues [active] 405955006806 effector binding site; other site 405955006807 R2 peptide binding site; other site 405955006808 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 405955006809 dimer interface [polypeptide binding]; other site 405955006810 putative radical transfer pathway; other site 405955006811 diiron center [ion binding]; other site 405955006812 tyrosyl radical; other site 405955006813 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 405955006814 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405955006815 catalytic loop [active] 405955006816 iron binding site [ion binding]; other site 405955006817 hypothetical protein; Provisional; Region: PRK09902 405955006818 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 405955006819 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 405955006820 active site 405955006821 catalytic site [active] 405955006822 metal binding site [ion binding]; metal-binding site 405955006823 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 405955006824 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955006825 putative substrate translocation pore; other site 405955006826 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 405955006827 hydroxyglutarate oxidase; Provisional; Region: PRK11728 405955006828 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405955006829 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 405955006830 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 405955006831 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 405955006832 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405955006833 Cysteine-rich domain; Region: CCG; pfam02754 405955006834 Cysteine-rich domain; Region: CCG; pfam02754 405955006835 hypothetical protein; Provisional; Region: PRK09956 405955006836 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 405955006837 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 405955006838 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 405955006839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955006840 putative substrate translocation pore; other site 405955006841 L-rhamnonate dehydratase; Provisional; Region: PRK15440 405955006842 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 405955006843 putative active site pocket [active] 405955006844 putative metal binding site [ion binding]; other site 405955006845 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 405955006846 Transcriptional regulator [Transcription]; Region: IclR; COG1414 405955006847 Bacterial transcriptional regulator; Region: IclR; pfam01614 405955006848 hypothetical protein; Provisional; Region: PRK03673 405955006849 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 405955006850 putative MPT binding site; other site 405955006851 Competence-damaged protein; Region: CinA; cl00666 405955006852 YfaZ precursor; Region: YfaZ; pfam07437 405955006853 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 405955006854 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 405955006855 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 405955006856 catalytic core [active] 405955006857 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 405955006858 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 405955006859 inhibitor-cofactor binding pocket; inhibition site 405955006860 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955006861 catalytic residue [active] 405955006862 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 405955006863 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 405955006864 Ligand binding site; other site 405955006865 Putative Catalytic site; other site 405955006866 DXD motif; other site 405955006867 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 405955006868 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 405955006869 substrate binding site [chemical binding]; other site 405955006870 cosubstrate binding site; other site 405955006871 catalytic site [active] 405955006872 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 405955006873 active site 405955006874 hexamer interface [polypeptide binding]; other site 405955006875 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 405955006876 NAD binding site [chemical binding]; other site 405955006877 substrate binding site [chemical binding]; other site 405955006878 active site 405955006879 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 405955006880 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 405955006881 putative active site [active] 405955006882 putative catalytic site [active] 405955006883 putative Zn binding site [ion binding]; other site 405955006884 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 405955006885 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 405955006886 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 405955006887 signal transduction protein PmrD; Provisional; Region: PRK15450 405955006888 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 405955006889 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 405955006890 acyl-activating enzyme (AAE) consensus motif; other site 405955006891 putative AMP binding site [chemical binding]; other site 405955006892 putative active site [active] 405955006893 putative CoA binding site [chemical binding]; other site 405955006894 O-succinylbenzoate synthase; Provisional; Region: PRK05105 405955006895 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 405955006896 active site 405955006897 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405955006898 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 405955006899 substrate binding site [chemical binding]; other site 405955006900 oxyanion hole (OAH) forming residues; other site 405955006901 trimer interface [polypeptide binding]; other site 405955006902 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 405955006903 Novel bacterial esterase that cleaves esters on halogenated cyclic compounds; Region: Esterase_713_like; cl17303 405955006904 catalytic site [active] 405955006905 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 405955006906 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 405955006907 dimer interface [polypeptide binding]; other site 405955006908 tetramer interface [polypeptide binding]; other site 405955006909 PYR/PP interface [polypeptide binding]; other site 405955006910 TPP binding site [chemical binding]; other site 405955006911 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 405955006912 TPP-binding site; other site 405955006913 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 405955006914 isochorismate synthases; Region: isochor_syn; TIGR00543 405955006915 hypothetical protein; Provisional; Region: PRK10404 405955006916 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405955006917 Coenzyme A binding pocket [chemical binding]; other site 405955006918 Metallo-beta-lactamase superfamily; Region: Lactamase_B; cl00446 405955006919 von Willebrand factor; Region: vWF_A; pfam12450 405955006920 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 405955006921 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 405955006922 metal ion-dependent adhesion site (MIDAS); other site 405955006923 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 405955006924 M28 Zn-Peptidases; Region: M28_like_1; cd05640 405955006925 Peptidase family M28; Region: Peptidase_M28; pfam04389 405955006926 metal binding site [ion binding]; metal-binding site 405955006927 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 405955006928 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 405955006929 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405955006930 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 405955006931 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405955006932 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 405955006933 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 405955006934 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405955006935 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 405955006936 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 405955006937 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 405955006938 4Fe-4S binding domain; Region: Fer4; pfam00037 405955006939 4Fe-4S binding domain; Region: Fer4; pfam00037 405955006940 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 405955006941 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 405955006942 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405955006943 catalytic loop [active] 405955006944 iron binding site [ion binding]; other site 405955006945 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 405955006946 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 405955006947 [4Fe-4S] binding site [ion binding]; other site 405955006948 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 405955006949 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 405955006950 SLBB domain; Region: SLBB; pfam10531 405955006951 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 405955006952 NADH dehydrogenase subunit E; Validated; Region: PRK07539 405955006953 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 405955006954 putative dimer interface [polypeptide binding]; other site 405955006955 [2Fe-2S] cluster binding site [ion binding]; other site 405955006956 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 405955006957 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 405955006958 NADH dehydrogenase subunit D; Validated; Region: PRK06075 405955006959 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 405955006960 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 405955006961 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 405955006962 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955006963 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 405955006964 putative dimerization interface [polypeptide binding]; other site 405955006965 aminotransferase AlaT; Validated; Region: PRK09265 405955006966 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405955006967 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955006968 homodimer interface [polypeptide binding]; other site 405955006969 catalytic residue [active] 405955006970 5'-nucleotidase; Provisional; Region: PRK03826 405955006971 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 405955006972 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 405955006973 TrkA-C domain; Region: TrkA_C; pfam02080 405955006974 TrkA-C domain; Region: TrkA_C; pfam02080 405955006975 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 405955006976 putative phosphatase; Provisional; Region: PRK11587 405955006977 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955006978 motif II; other site 405955006979 hypothetical protein; Validated; Region: PRK05445 405955006980 hypothetical protein; Provisional; Region: PRK01816 405955006981 propionate/acetate kinase; Provisional; Region: PRK12379 405955006982 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 405955006983 hypothetical protein; Provisional; Region: PRK11588 405955006984 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 405955006985 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 405955006986 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 405955006987 nudix motif; other site 405955006988 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 405955006989 active site 405955006990 metal binding site [ion binding]; metal-binding site 405955006991 homotetramer interface [polypeptide binding]; other site 405955006992 glutathione S-transferase; Provisional; Region: PRK15113 405955006993 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 405955006994 C-terminal domain interface [polypeptide binding]; other site 405955006995 GSH binding site (G-site) [chemical binding]; other site 405955006996 dimer interface [polypeptide binding]; other site 405955006997 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 405955006998 N-terminal domain interface [polypeptide binding]; other site 405955006999 putative dimer interface [polypeptide binding]; other site 405955007000 putative substrate binding pocket (H-site) [chemical binding]; other site 405955007001 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 405955007002 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 405955007003 C-terminal domain interface [polypeptide binding]; other site 405955007004 GSH binding site (G-site) [chemical binding]; other site 405955007005 dimer interface [polypeptide binding]; other site 405955007006 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 405955007007 N-terminal domain interface [polypeptide binding]; other site 405955007008 putative dimer interface [polypeptide binding]; other site 405955007009 active site 405955007010 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 405955007011 homooctamer interface [polypeptide binding]; other site 405955007012 active site 405955007013 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 405955007014 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 405955007015 putative NAD(P) binding site [chemical binding]; other site 405955007016 putative active site [active] 405955007017 putative transposase; Provisional; Region: PRK09857 405955007018 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 405955007019 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 405955007020 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405955007021 Walker A/P-loop; other site 405955007022 ATP binding site [chemical binding]; other site 405955007023 Q-loop/lid; other site 405955007024 ABC transporter signature motif; other site 405955007025 Walker B; other site 405955007026 D-loop; other site 405955007027 H-loop/switch region; other site 405955007028 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955007029 dimer interface [polypeptide binding]; other site 405955007030 conserved gate region; other site 405955007031 putative PBP binding loops; other site 405955007032 ABC-ATPase subunit interface; other site 405955007033 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405955007034 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955007035 dimer interface [polypeptide binding]; other site 405955007036 conserved gate region; other site 405955007037 putative PBP binding loops; other site 405955007038 ABC-ATPase subunit interface; other site 405955007039 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 405955007040 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955007041 substrate binding pocket [chemical binding]; other site 405955007042 membrane-bound complex binding site; other site 405955007043 hinge residues; other site 405955007044 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 405955007045 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955007046 substrate binding pocket [chemical binding]; other site 405955007047 membrane-bound complex binding site; other site 405955007048 hinge residues; other site 405955007049 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 405955007050 Flavoprotein; Region: Flavoprotein; pfam02441 405955007051 amidophosphoribosyltransferase; Provisional; Region: PRK09246 405955007052 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 405955007053 active site 405955007054 tetramer interface [polypeptide binding]; other site 405955007055 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405955007056 active site 405955007057 colicin V production protein; Provisional; Region: PRK10845 405955007058 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 405955007059 cell division protein DedD; Provisional; Region: PRK11633 405955007060 Sporulation related domain; Region: SPOR; pfam05036 405955007061 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 405955007062 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405955007063 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405955007064 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 405955007065 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 405955007066 hypothetical protein; Provisional; Region: PRK10847 405955007067 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405955007068 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 405955007069 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 405955007070 dimerization interface 3.5A [polypeptide binding]; other site 405955007071 active site 405955007072 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 405955007073 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405955007074 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 405955007075 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 405955007076 ligand binding site [chemical binding]; other site 405955007077 NAD binding site [chemical binding]; other site 405955007078 catalytic site [active] 405955007079 homodimer interface [polypeptide binding]; other site 405955007080 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 405955007081 putative transporter; Provisional; Region: PRK12382 405955007082 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955007083 putative substrate translocation pore; other site 405955007084 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 405955007085 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 405955007086 dimer interface [polypeptide binding]; other site 405955007087 active site 405955007088 Uncharacterized conserved protein [Function unknown]; Region: COG4121 405955007089 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 405955007090 YfcL protein; Region: YfcL; pfam08891 405955007091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 405955007092 hypothetical protein; Provisional; Region: PRK10621 405955007093 Predicted permeases [General function prediction only]; Region: COG0730 405955007094 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 405955007095 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 405955007096 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 405955007097 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 405955007098 Tetramer interface [polypeptide binding]; other site 405955007099 active site 405955007100 FMN-binding site [chemical binding]; other site 405955007101 HemK family putative methylases; Region: hemK_fam; TIGR00536 405955007102 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955007103 S-adenosylmethionine binding site [chemical binding]; other site 405955007104 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 405955007105 Fimbrial protein; Region: Fimbrial; cl01416 405955007106 Fimbrial protein; Region: Fimbrial; cl01416 405955007107 Fimbrial protein; Region: Fimbrial; cl01416 405955007108 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 405955007109 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 405955007110 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 405955007111 PapC N-terminal domain; Region: PapC_N; pfam13954 405955007112 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 405955007113 PapC C-terminal domain; Region: PapC_C; pfam13953 405955007114 Fimbrial protein; Region: Fimbrial; cl01416 405955007115 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405955007116 catalytic core [active] 405955007117 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 405955007118 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405955007119 substrate binding site [chemical binding]; other site 405955007120 oxyanion hole (OAH) forming residues; other site 405955007121 trimer interface [polypeptide binding]; other site 405955007122 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 405955007123 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405955007124 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 405955007125 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405955007126 dimer interface [polypeptide binding]; other site 405955007127 active site 405955007128 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 405955007129 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 405955007130 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 405955007131 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 405955007132 integrase; Provisional; Region: PRK09692 405955007133 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 405955007134 active site 405955007135 Int/Topo IB signature motif; other site 405955007136 SH3 domain protein; Region: SH3_and_anchor; TIGR04211 405955007137 Acetyltransferase (isoleucine patch superfamily) [General function prediction only]; Region: WbbJ; COG0110 405955007138 Maltose O-acyltransferase (MAT)-like: This family is composed of maltose O-acetyltransferase, galactoside O-acetyltransferase (GAT), xenobiotic acyltransferase (XAT) and similar proteins. MAT and GAT catalyze the CoA-dependent acetylation of the...; Region: LbH_MAT_like; cd04647 405955007139 trimer interface [polypeptide binding]; other site 405955007140 active site 405955007141 substrate binding site [chemical binding]; other site 405955007142 CoA binding site [chemical binding]; other site 405955007143 Head binding; Region: Head_binding; pfam09008 405955007144 N terminal extension of bacteriophage endosialidase; Region: End_N_terminal; pfam12218 405955007145 Beta barrel domain of bacteriophage endosialidase; Region: End_beta_barrel; pfam12195 405955007146 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 405955007147 Asp-box motif; other site 405955007148 catalytic site [active] 405955007149 Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219 405955007150 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 405955007151 P22_AR N-terminal domain; Region: P22_AR_N; pfam10547 405955007152 Phage anti-repressor protein [Transcription]; Region: COG3561 405955007153 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 405955007154 active site 405955007155 Toxin YafO, type II toxin-antitoxin system; Region: YafO_toxin; pfam13957 405955007156 Protein of unknown function (DUF2824); Region: DUF2824; pfam11039 405955007157 Phage stabilisation protein; Region: Phage_stabilise; pfam11134 405955007158 P22 tail accessory factor; Region: P22_Tail-4; pfam11650 405955007159 P22 coat protein - gene protein 5; Region: P22_CoatProtein; pfam11651 405955007160 coat protein; Region: PHA01511 405955007161 Phage terminase large subunit; Region: Terminase_3; pfam04466 405955007162 Protein of unknown function (DUF2560); Region: DUF2560; pfam10834 405955007163 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 405955007164 ORF11CD3 domain; Region: ORF11CD3; pfam10549 405955007165 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 405955007166 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 405955007167 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405955007168 catalytic residue [active] 405955007169 phage holin, lambda family; Region: holin_lambda; TIGR01594 405955007170 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 405955007171 Endodeoxyribonuclease RusA; Region: RusA; cl01885 405955007172 Protein of unknown function (DUF1364); Region: DUF1364; pfam07102 405955007173 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 405955007174 Uncharacterized phage-encoded protein [Function unknown]; Region: COG3645 405955007175 Protein of unknown function (DUF2591); Region: DUF2591; pfam10765 405955007176 NinB protein; Region: NinB; pfam05772 405955007177 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405955007178 DnaB-like helicase C terminal domain; Region: DnaB_C; pfam03796 405955007179 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405955007180 Walker A motif; other site 405955007181 ATP binding site [chemical binding]; other site 405955007182 Walker B motif; other site 405955007183 DNA binding loops [nucleotide binding] 405955007184 Bacteriophage replication protein O; Region: Phage_rep_O; pfam04492 405955007185 Bacteriophage CII protein; Region: Phage_CII; pfam05269 405955007186 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 405955007187 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955007188 non-specific DNA binding site [nucleotide binding]; other site 405955007189 salt bridge; other site 405955007190 sequence-specific DNA binding site [nucleotide binding]; other site 405955007191 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 405955007192 Catalytic site [active] 405955007193 ERF superfamily; Region: ERF; pfam04404 405955007194 Protein of unknown function (DUF2856); Region: DUF2856; pfam11043 405955007195 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 405955007196 Protein of unknown function (DUF551); Region: DUF551; pfam04448 405955007197 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 405955007198 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955007199 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 405955007200 dimerization interface [polypeptide binding]; other site 405955007201 substrate binding pocket [chemical binding]; other site 405955007202 permease DsdX; Provisional; Region: PRK09921 405955007203 gluconate transporter; Region: gntP; TIGR00791 405955007204 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 405955007205 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 405955007206 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405955007207 catalytic residue [active] 405955007208 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405955007209 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955007210 putative substrate translocation pore; other site 405955007211 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955007212 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 405955007213 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955007214 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 405955007215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955007216 active site 405955007217 phosphorylation site [posttranslational modification] 405955007218 intermolecular recognition site; other site 405955007219 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955007220 DNA binding residues [nucleotide binding] 405955007221 dimerization interface [polypeptide binding]; other site 405955007222 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 405955007223 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955007224 substrate binding pocket [chemical binding]; other site 405955007225 membrane-bound complex binding site; other site 405955007226 hinge residues; other site 405955007227 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955007228 substrate binding pocket [chemical binding]; other site 405955007229 membrane-bound complex binding site; other site 405955007230 hinge residues; other site 405955007231 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955007232 dimer interface [polypeptide binding]; other site 405955007233 phosphorylation site [posttranslational modification] 405955007234 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955007235 ATP binding site [chemical binding]; other site 405955007236 Mg2+ binding site [ion binding]; other site 405955007237 G-X-G motif; other site 405955007238 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955007239 active site 405955007240 phosphorylation site [posttranslational modification] 405955007241 intermolecular recognition site; other site 405955007242 dimerization interface [polypeptide binding]; other site 405955007243 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 405955007244 putative binding surface; other site 405955007245 active site 405955007246 putative CoA-transferase; Provisional; Region: PRK11430 405955007247 CoA-transferase family III; Region: CoA_transf_3; pfam02515 405955007248 putative transporter YfdV; Provisional; Region: PRK09903 405955007249 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 405955007250 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405955007251 PYR/PP interface [polypeptide binding]; other site 405955007252 dimer interface [polypeptide binding]; other site 405955007253 TPP binding site [chemical binding]; other site 405955007254 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405955007255 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 405955007256 TPP-binding site; other site 405955007257 dimer interface [polypeptide binding]; other site 405955007258 formyl-coenzyme A transferase; Provisional; Region: PRK05398 405955007259 CoA-transferase family III; Region: CoA_transf_3; pfam02515 405955007260 hypothetical protein; Provisional; Region: PRK10316 405955007261 YfdX protein; Region: YfdX; pfam10938 405955007262 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 405955007263 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 405955007264 putative acyl-acceptor binding pocket; other site 405955007265 aminotransferase; Validated; Region: PRK08175 405955007266 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405955007267 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955007268 homodimer interface [polypeptide binding]; other site 405955007269 catalytic residue [active] 405955007270 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 405955007271 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 405955007272 GAF domain; Region: GAF; cl17456 405955007273 Histidine kinase; Region: His_kinase; pfam06580 405955007274 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955007275 ATP binding site [chemical binding]; other site 405955007276 Mg2+ binding site [ion binding]; other site 405955007277 G-X-G motif; other site 405955007278 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 405955007279 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955007280 active site 405955007281 phosphorylation site [posttranslational modification] 405955007282 intermolecular recognition site; other site 405955007283 dimerization interface [polypeptide binding]; other site 405955007284 LytTr DNA-binding domain; Region: LytTR; pfam04397 405955007285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405955007286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955007287 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405955007288 dimerization domain swap beta strand [polypeptide binding]; other site 405955007289 regulatory protein interface [polypeptide binding]; other site 405955007290 active site 405955007291 regulatory phosphorylation site [posttranslational modification]; other site 405955007292 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 405955007293 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 405955007294 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405955007295 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 405955007296 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405955007297 active site 405955007298 phosphorylation site [posttranslational modification] 405955007299 exoaminopeptidase; Provisional; Region: PRK09961 405955007300 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 405955007301 oligomer interface [polypeptide binding]; other site 405955007302 active site 405955007303 metal binding site [ion binding]; metal-binding site 405955007304 aminopeptidase; Provisional; Region: PRK09795 405955007305 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 405955007306 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 405955007307 active site 405955007308 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 405955007309 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 405955007310 active site 405955007311 P-loop; other site 405955007312 phosphorylation site [posttranslational modification] 405955007313 glucokinase, proteobacterial type; Region: glk; TIGR00749 405955007314 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405955007315 nucleotide binding site [chemical binding]; other site 405955007316 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 405955007317 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 405955007318 Cl- selectivity filter; other site 405955007319 Cl- binding residues [ion binding]; other site 405955007320 pore gating glutamate residue; other site 405955007321 dimer interface [polypeptide binding]; other site 405955007322 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 405955007323 manganese transport protein MntH; Reviewed; Region: PRK00701 405955007324 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 405955007325 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 405955007326 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 405955007327 Nucleoside recognition; Region: Gate; pfam07670 405955007328 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 405955007329 MASE1; Region: MASE1; pfam05231 405955007330 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405955007331 diguanylate cyclase; Region: GGDEF; smart00267 405955007332 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955007333 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 405955007334 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955007335 salt bridge; other site 405955007336 non-specific DNA binding site [nucleotide binding]; other site 405955007337 sequence-specific DNA binding site [nucleotide binding]; other site 405955007338 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 405955007339 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 405955007340 active site 405955007341 HIGH motif; other site 405955007342 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 405955007343 active site 405955007344 KMSKS motif; other site 405955007345 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 405955007346 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955007347 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 405955007348 putative dimerization interface [polypeptide binding]; other site 405955007349 putative substrate binding pocket [chemical binding]; other site 405955007350 nucleoside transporter; Region: 2A0110; TIGR00889 405955007351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955007352 putative substrate translocation pore; other site 405955007353 purine nucleoside phosphorylase; Provisional; Region: PRK08202 405955007354 hypothetical protein; Provisional; Region: PRK11528 405955007355 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 405955007356 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 405955007357 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 405955007358 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 405955007359 nucleotide binding pocket [chemical binding]; other site 405955007360 K-X-D-G motif; other site 405955007361 catalytic site [active] 405955007362 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 405955007363 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 405955007364 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 405955007365 Dimer interface [polypeptide binding]; other site 405955007366 BRCT sequence motif; other site 405955007367 cell division protein ZipA; Provisional; Region: PRK03427 405955007368 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 405955007369 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 405955007370 FtsZ protein binding site [polypeptide binding]; other site 405955007371 putative sulfate transport protein CysZ; Validated; Region: PRK04949 405955007372 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 405955007373 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405955007374 dimer interface [polypeptide binding]; other site 405955007375 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955007376 catalytic residue [active] 405955007377 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 405955007378 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 405955007379 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405955007380 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 405955007381 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 405955007382 HPr interaction site; other site 405955007383 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405955007384 active site 405955007385 phosphorylation site [posttranslational modification] 405955007386 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 405955007387 dimer interface [polypeptide binding]; other site 405955007388 pyridoxamine kinase; Validated; Region: PRK05756 405955007389 pyridoxal binding site [chemical binding]; other site 405955007390 ATP binding site [chemical binding]; other site 405955007391 hypothetical protein; Provisional; Region: PRK10318 405955007392 cysteine synthase B; Region: cysM; TIGR01138 405955007393 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 405955007394 dimer interface [polypeptide binding]; other site 405955007395 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955007396 catalytic residue [active] 405955007397 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 405955007398 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 405955007399 Walker A/P-loop; other site 405955007400 ATP binding site [chemical binding]; other site 405955007401 Q-loop/lid; other site 405955007402 ABC transporter signature motif; other site 405955007403 Walker B; other site 405955007404 D-loop; other site 405955007405 H-loop/switch region; other site 405955007406 TOBE-like domain; Region: TOBE_3; pfam12857 405955007407 sulfate transport protein; Provisional; Region: cysT; CHL00187 405955007408 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955007409 dimer interface [polypeptide binding]; other site 405955007410 conserved gate region; other site 405955007411 putative PBP binding loops; other site 405955007412 ABC-ATPase subunit interface; other site 405955007413 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 405955007414 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955007415 dimer interface [polypeptide binding]; other site 405955007416 conserved gate region; other site 405955007417 putative PBP binding loops; other site 405955007418 ABC-ATPase subunit interface; other site 405955007419 thiosulfate transporter subunit; Provisional; Region: PRK10852 405955007420 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 405955007421 short chain dehydrogenase; Provisional; Region: PRK08226 405955007422 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 405955007423 NAD binding site [chemical binding]; other site 405955007424 homotetramer interface [polypeptide binding]; other site 405955007425 homodimer interface [polypeptide binding]; other site 405955007426 active site 405955007427 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 405955007428 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 405955007429 putative active site [active] 405955007430 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 405955007431 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405955007432 active site turn [active] 405955007433 phosphorylation site [posttranslational modification] 405955007434 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405955007435 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 405955007436 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 405955007437 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 405955007438 putative acetyltransferase; Provisional; Region: PRK03624 405955007439 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405955007440 Coenzyme A binding pocket [chemical binding]; other site 405955007441 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 405955007442 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405955007443 active site 405955007444 metal binding site [ion binding]; metal-binding site 405955007445 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 405955007446 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 405955007447 transcriptional regulator EutR; Provisional; Region: PRK10130 405955007448 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955007449 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955007450 carboxysome structural protein EutK; Provisional; Region: PRK15466 405955007451 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 405955007452 Hexamer interface [polypeptide binding]; other site 405955007453 Hexagonal pore residue; other site 405955007454 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 405955007455 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 405955007456 putative hexamer interface [polypeptide binding]; other site 405955007457 putative hexagonal pore; other site 405955007458 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 405955007459 putative hexamer interface [polypeptide binding]; other site 405955007460 putative hexagonal pore; other site 405955007461 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 405955007462 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 405955007463 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 405955007464 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 405955007465 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 405955007466 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 405955007467 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 405955007468 active site 405955007469 metal binding site [ion binding]; metal-binding site 405955007470 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 405955007471 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405955007472 nucleotide binding site [chemical binding]; other site 405955007473 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 405955007474 putative catalytic cysteine [active] 405955007475 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 405955007476 Hexamer/Pentamer interface [polypeptide binding]; other site 405955007477 central pore; other site 405955007478 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 405955007479 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 405955007480 Hexamer interface [polypeptide binding]; other site 405955007481 Hexagonal pore residue; other site 405955007482 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 405955007483 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 405955007484 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 405955007485 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 405955007486 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 405955007487 G1 box; other site 405955007488 GTP/Mg2+ binding site [chemical binding]; other site 405955007489 G2 box; other site 405955007490 Switch I region; other site 405955007491 G3 box; other site 405955007492 Switch II region; other site 405955007493 G4 box; other site 405955007494 G5 box; other site 405955007495 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 405955007496 putative hexamer interface [polypeptide binding]; other site 405955007497 putative hexagonal pore; other site 405955007498 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 405955007499 Malic enzyme, N-terminal domain; Region: malic; pfam00390 405955007500 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 405955007501 putative NAD(P) binding site [chemical binding]; other site 405955007502 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 405955007503 transaldolase-like protein; Provisional; Region: PTZ00411 405955007504 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 405955007505 active site 405955007506 dimer interface [polypeptide binding]; other site 405955007507 catalytic residue [active] 405955007508 transketolase; Reviewed; Region: PRK12753 405955007509 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 405955007510 TPP-binding site [chemical binding]; other site 405955007511 dimer interface [polypeptide binding]; other site 405955007512 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405955007513 PYR/PP interface [polypeptide binding]; other site 405955007514 dimer interface [polypeptide binding]; other site 405955007515 TPP binding site [chemical binding]; other site 405955007516 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405955007517 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 405955007518 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 405955007519 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 405955007520 dimer interface [polypeptide binding]; other site 405955007521 ADP-ribose binding site [chemical binding]; other site 405955007522 active site 405955007523 nudix motif; other site 405955007524 metal binding site [ion binding]; metal-binding site 405955007525 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 405955007526 4Fe-4S binding domain; Region: Fer4; pfam00037 405955007527 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405955007528 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955007529 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 405955007530 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 405955007531 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405955007532 dimerization interface [polypeptide binding]; other site 405955007533 Histidine kinase; Region: HisKA_3; pfam07730 405955007534 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955007535 ATP binding site [chemical binding]; other site 405955007536 Mg2+ binding site [ion binding]; other site 405955007537 G-X-G motif; other site 405955007538 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 405955007539 Protein export membrane protein; Region: SecD_SecF; cl14618 405955007540 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 405955007541 ArsC family; Region: ArsC; pfam03960 405955007542 putative catalytic residues [active] 405955007543 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 405955007544 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 405955007545 metal binding site [ion binding]; metal-binding site 405955007546 dimer interface [polypeptide binding]; other site 405955007547 putative hydrolase; Provisional; Region: PRK11460 405955007548 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 405955007549 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 405955007550 Domain of unknown function (DUF1726); Region: DUF1726; pfam08351 405955007551 Helicase; Region: Helicase_RecD; pfam05127 405955007552 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 405955007553 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 405955007554 Predicted metalloprotease [General function prediction only]; Region: COG2321 405955007555 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 405955007556 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 405955007557 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 405955007558 ATP binding site [chemical binding]; other site 405955007559 active site 405955007560 substrate binding site [chemical binding]; other site 405955007561 lipoprotein; Provisional; Region: PRK11679 405955007562 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 405955007563 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 405955007564 dihydrodipicolinate synthase; Region: dapA; TIGR00674 405955007565 dimer interface [polypeptide binding]; other site 405955007566 active site 405955007567 catalytic residue [active] 405955007568 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 405955007569 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 405955007570 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 405955007571 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 405955007572 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 405955007573 catalytic triad [active] 405955007574 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 405955007575 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405955007576 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 405955007577 Peptidase family M48; Region: Peptidase_M48; cl12018 405955007578 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 405955007579 ArsC family; Region: ArsC; pfam03960 405955007580 catalytic residues [active] 405955007581 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 405955007582 DNA replication initiation factor; Provisional; Region: PRK08084 405955007583 uracil transporter; Provisional; Region: PRK10720 405955007584 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405955007585 active site 405955007586 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 405955007587 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 405955007588 dimerization interface [polypeptide binding]; other site 405955007589 putative ATP binding site [chemical binding]; other site 405955007590 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 405955007591 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 405955007592 active site 405955007593 substrate binding site [chemical binding]; other site 405955007594 cosubstrate binding site; other site 405955007595 catalytic site [active] 405955007596 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 405955007597 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 405955007598 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 405955007599 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 405955007600 domain interface [polypeptide binding]; other site 405955007601 active site 405955007602 catalytic site [active] 405955007603 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 405955007604 putative active site [active] 405955007605 catalytic site [active] 405955007606 exopolyphosphatase; Provisional; Region: PRK10854 405955007607 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 405955007608 MASE1; Region: MASE1; pfam05231 405955007609 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 405955007610 diguanylate cyclase; Region: GGDEF; smart00267 405955007611 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955007612 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 405955007613 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 405955007614 Predicted chitinase [General function prediction only]; Region: COG3179 405955007615 catalytic residue [active] 405955007616 Protein of unknown function (DUF754); Region: DUF754; pfam05449 405955007617 N terminal extension of bacteriophage endosialidase; Region: End_N_terminal; pfam12218 405955007618 Catalytic beta propeller domain of bacteriophage endosialidase; Region: End_beta_propel; cl12167 405955007619 Sialidases or neuraminidases function to bind and hydrolyze terminal sialic acid residues from various glycoconjugates as well as playing roles in pathogenesis, bacterial nutrition and cellular interactions. They have a six-bladed, beta-propeller fold...; Region: Sialidase; cd00260 405955007620 Asp-box motif; other site 405955007621 catalytic site [active] 405955007622 Catalytic domain of bacteriophage endosialidase; Region: End_tail_spike; pfam12219 405955007623 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 405955007624 Prophage antirepressor [Transcription]; Region: COG3617 405955007625 BRO family, N-terminal domain; Region: Bro-N; smart01040 405955007626 structural protein; Region: PHA01972 405955007627 virion protein; Provisional; Region: V; PHA02564 405955007628 hypothetical protein; Region: PHA01733 405955007629 hypothetical protein; Region: PHA00661 405955007630 hypothetical protein; Region: PHA00662 405955007631 hypothetical protein; Region: PHA00669 405955007632 hypothetical protein; Region: PHA00664 405955007633 major capsid protein; Region: PHA00665 405955007634 putative protease; Region: PHA00666 405955007635 hypothetical protein; Region: PHA00670 405955007636 Bacteriophage head to tail connecting protein; Region: Head-tail_con; pfam12236 405955007637 hypothetical protein; Region: PHA01971 405955007638 Terminase small subunit; Region: Terminase_2; pfam03592 405955007639 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 405955007640 Protein of unknown function (DUF551); Region: DUF551; pfam04448 405955007641 Protein of unknown function (DUF1064); Region: DUF1064; pfam06356 405955007642 Replication protein P; Region: Phage_lambda_P; pfam06992 405955007643 primosomal protein DnaI; Provisional; Region: PRK02854 405955007644 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955007645 sequence-specific DNA binding site [nucleotide binding]; other site 405955007646 salt bridge; other site 405955007647 YqaJ-like viral recombinase domain; Region: YqaJ; cl09232 405955007648 recombination and repair protein RecT; Reviewed; Region: recT; PRK09846 405955007649 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; cl17523 405955007650 MT-A70; Region: MT-A70; cl01947 405955007651 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 405955007652 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405955007653 active site 405955007654 metal binding site [ion binding]; metal-binding site 405955007655 integrase; Provisional; Region: PRK09692 405955007656 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 405955007657 active site 405955007658 Int/Topo IB signature motif; other site 405955007659 GMP synthase; Reviewed; Region: guaA; PRK00074 405955007660 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 405955007661 AMP/PPi binding site [chemical binding]; other site 405955007662 candidate oxyanion hole; other site 405955007663 catalytic triad [active] 405955007664 potential glutamine specificity residues [chemical binding]; other site 405955007665 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 405955007666 ATP Binding subdomain [chemical binding]; other site 405955007667 Ligand Binding sites [chemical binding]; other site 405955007668 Dimerization subdomain; other site 405955007669 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 405955007670 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 405955007671 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 405955007672 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 405955007673 active site 405955007674 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 405955007675 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 405955007676 generic binding surface II; other site 405955007677 generic binding surface I; other site 405955007678 RatA-like protein; Provisional; Region: PRK15316 405955007679 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 405955007680 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 405955007681 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 405955007682 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 405955007683 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 405955007684 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 405955007685 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 405955007686 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 405955007687 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 405955007688 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 405955007689 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 405955007690 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 405955007691 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 405955007692 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 405955007693 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 405955007694 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 405955007695 Salmonella repeat of unknown function (DUF824); Region: DUF824; pfam05688 405955007696 Salmonella repeat of unknown function (DUF823); Region: DUF823; pfam05689 405955007697 intimin-like protein SinH; Provisional; Region: PRK15318 405955007698 intimin-like protein SinH; Provisional; Region: PRK15318 405955007699 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 405955007700 GTP-binding protein Der; Reviewed; Region: PRK00093 405955007701 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 405955007702 G1 box; other site 405955007703 GTP/Mg2+ binding site [chemical binding]; other site 405955007704 Switch I region; other site 405955007705 G2 box; other site 405955007706 Switch II region; other site 405955007707 G3 box; other site 405955007708 G4 box; other site 405955007709 G5 box; other site 405955007710 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 405955007711 G1 box; other site 405955007712 GTP/Mg2+ binding site [chemical binding]; other site 405955007713 Switch I region; other site 405955007714 G2 box; other site 405955007715 G3 box; other site 405955007716 Switch II region; other site 405955007717 G4 box; other site 405955007718 G5 box; other site 405955007719 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 405955007720 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 405955007721 Trp docking motif [polypeptide binding]; other site 405955007722 active site 405955007723 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 405955007724 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 405955007725 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 405955007726 dimer interface [polypeptide binding]; other site 405955007727 motif 1; other site 405955007728 active site 405955007729 motif 2; other site 405955007730 motif 3; other site 405955007731 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 405955007732 anticodon binding site; other site 405955007733 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 405955007734 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 405955007735 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 405955007736 cytoskeletal protein RodZ; Provisional; Region: PRK10856 405955007737 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955007738 non-specific DNA binding site [nucleotide binding]; other site 405955007739 salt bridge; other site 405955007740 sequence-specific DNA binding site [nucleotide binding]; other site 405955007741 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 405955007742 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 405955007743 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955007744 FeS/SAM binding site; other site 405955007745 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 405955007746 active site 405955007747 multimer interface [polypeptide binding]; other site 405955007748 penicillin-binding protein 1C; Provisional; Region: PRK11240 405955007749 Transglycosylase; Region: Transgly; pfam00912 405955007750 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 405955007751 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 405955007752 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 405955007753 MG2 domain; Region: A2M_N; pfam01835 405955007754 Alpha-2-macroglobulin family; Region: A2M; pfam00207 405955007755 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 405955007756 surface patch; other site 405955007757 thioester region; other site 405955007758 specificity defining residues; other site 405955007759 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 405955007760 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 405955007761 active site residue [active] 405955007762 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 405955007763 active site residue [active] 405955007764 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 405955007765 aminopeptidase B; Provisional; Region: PRK05015 405955007766 Peptidase; Region: DUF3663; pfam12404 405955007767 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 405955007768 interface (dimer of trimers) [polypeptide binding]; other site 405955007769 Substrate-binding/catalytic site; other site 405955007770 Zn-binding sites [ion binding]; other site 405955007771 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 405955007772 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 405955007773 catalytic loop [active] 405955007774 iron binding site [ion binding]; other site 405955007775 chaperone protein HscA; Provisional; Region: hscA; PRK05183 405955007776 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 405955007777 nucleotide binding site [chemical binding]; other site 405955007778 putative NEF/HSP70 interaction site [polypeptide binding]; other site 405955007779 SBD interface [polypeptide binding]; other site 405955007780 co-chaperone HscB; Provisional; Region: hscB; PRK05014 405955007781 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 405955007782 HSP70 interaction site [polypeptide binding]; other site 405955007783 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 405955007784 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 405955007785 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 405955007786 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 405955007787 trimerization site [polypeptide binding]; other site 405955007788 active site 405955007789 cysteine desulfurase; Provisional; Region: PRK14012 405955007790 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 405955007791 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405955007792 catalytic residue [active] 405955007793 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 405955007794 Rrf2 family protein; Region: rrf2_super; TIGR00738 405955007795 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 405955007796 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 405955007797 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 405955007798 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 405955007799 active site 405955007800 dimerization interface [polypeptide binding]; other site 405955007801 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 405955007802 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405955007803 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 405955007804 PRD domain; Region: PRD; pfam00874 405955007805 PRD domain; Region: PRD; pfam00874 405955007806 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 405955007807 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955007808 putative substrate translocation pore; other site 405955007809 Predicted membrane protein [Function unknown]; Region: COG2259 405955007810 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 405955007811 active site 405955007812 catalytic residues [active] 405955007813 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405955007814 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 405955007815 putative NAD(P) binding site [chemical binding]; other site 405955007816 catalytic Zn binding site [ion binding]; other site 405955007817 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405955007818 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405955007819 TM-ABC transporter signature motif; other site 405955007820 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 405955007821 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405955007822 Walker A/P-loop; other site 405955007823 ATP binding site [chemical binding]; other site 405955007824 Q-loop/lid; other site 405955007825 ABC transporter signature motif; other site 405955007826 Walker B; other site 405955007827 D-loop; other site 405955007828 H-loop/switch region; other site 405955007829 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405955007830 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 405955007831 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 405955007832 ligand binding site [chemical binding]; other site 405955007833 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405955007834 TPR motif; other site 405955007835 Tetratricopeptide repeat; Region: TPR_16; pfam13432 405955007836 binding surface 405955007837 TPR repeat; Region: TPR_11; pfam13414 405955007838 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405955007839 TPR motif; other site 405955007840 binding surface 405955007841 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 405955007842 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 405955007843 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405955007844 nucleotide binding site [chemical binding]; other site 405955007845 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 405955007846 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 405955007847 dimer interface [polypeptide binding]; other site 405955007848 active site 405955007849 glycine-pyridoxal phosphate binding site [chemical binding]; other site 405955007850 folate binding site [chemical binding]; other site 405955007851 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 405955007852 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 405955007853 heme-binding site [chemical binding]; other site 405955007854 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 405955007855 FAD binding pocket [chemical binding]; other site 405955007856 FAD binding motif [chemical binding]; other site 405955007857 phosphate binding motif [ion binding]; other site 405955007858 beta-alpha-beta structure motif; other site 405955007859 NAD binding pocket [chemical binding]; other site 405955007860 Heme binding pocket [chemical binding]; other site 405955007861 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 405955007862 Nitrogen regulatory protein P-II; Region: P-II; smart00938 405955007863 response regulator GlrR; Provisional; Region: PRK15115 405955007864 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955007865 active site 405955007866 phosphorylation site [posttranslational modification] 405955007867 intermolecular recognition site; other site 405955007868 dimerization interface [polypeptide binding]; other site 405955007869 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955007870 Walker A motif; other site 405955007871 ATP binding site [chemical binding]; other site 405955007872 Walker B motif; other site 405955007873 arginine finger; other site 405955007874 hypothetical protein; Provisional; Region: PRK10722 405955007875 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 405955007876 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955007877 dimer interface [polypeptide binding]; other site 405955007878 phosphorylation site [posttranslational modification] 405955007879 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955007880 ATP binding site [chemical binding]; other site 405955007881 Mg2+ binding site [ion binding]; other site 405955007882 G-X-G motif; other site 405955007883 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 405955007884 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 405955007885 dimerization interface [polypeptide binding]; other site 405955007886 ATP binding site [chemical binding]; other site 405955007887 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 405955007888 dimerization interface [polypeptide binding]; other site 405955007889 ATP binding site [chemical binding]; other site 405955007890 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 405955007891 putative active site [active] 405955007892 catalytic triad [active] 405955007893 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 405955007894 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955007895 substrate binding pocket [chemical binding]; other site 405955007896 membrane-bound complex binding site; other site 405955007897 hinge residues; other site 405955007898 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405955007899 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405955007900 catalytic residue [active] 405955007901 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 405955007902 nucleoside/Zn binding site; other site 405955007903 dimer interface [polypeptide binding]; other site 405955007904 catalytic motif [active] 405955007905 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 405955007906 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 405955007907 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 405955007908 putative active site [active] 405955007909 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 405955007910 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 405955007911 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 405955007912 active site 405955007913 hydrophilic channel; other site 405955007914 dimerization interface [polypeptide binding]; other site 405955007915 catalytic residues [active] 405955007916 active site lid [active] 405955007917 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 405955007918 Recombination protein O N terminal; Region: RecO_N; pfam11967 405955007919 Recombination protein O C terminal; Region: RecO_C; pfam02565 405955007920 GTPase Era; Reviewed; Region: era; PRK00089 405955007921 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 405955007922 G1 box; other site 405955007923 GTP/Mg2+ binding site [chemical binding]; other site 405955007924 Switch I region; other site 405955007925 G2 box; other site 405955007926 Switch II region; other site 405955007927 G3 box; other site 405955007928 G4 box; other site 405955007929 G5 box; other site 405955007930 KH domain; Region: KH_2; pfam07650 405955007931 ribonuclease III; Reviewed; Region: rnc; PRK00102 405955007932 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 405955007933 dimerization interface [polypeptide binding]; other site 405955007934 active site 405955007935 metal binding site [ion binding]; metal-binding site 405955007936 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 405955007937 dsRNA binding site [nucleotide binding]; other site 405955007938 signal peptidase I; Provisional; Region: PRK10861 405955007939 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405955007940 Catalytic site [active] 405955007941 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 405955007942 GTP-binding protein LepA; Provisional; Region: PRK05433 405955007943 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 405955007944 G1 box; other site 405955007945 putative GEF interaction site [polypeptide binding]; other site 405955007946 GTP/Mg2+ binding site [chemical binding]; other site 405955007947 Switch I region; other site 405955007948 G2 box; other site 405955007949 G3 box; other site 405955007950 Switch II region; other site 405955007951 G4 box; other site 405955007952 G5 box; other site 405955007953 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 405955007954 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 405955007955 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 405955007956 SoxR reducing system protein RseC; Provisional; Region: PRK10862 405955007957 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 405955007958 anti-sigma E factor; Provisional; Region: rseB; PRK09455 405955007959 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 405955007960 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 405955007961 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 405955007962 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 405955007963 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405955007964 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405955007965 DNA binding residues [nucleotide binding] 405955007966 L-aspartate oxidase; Provisional; Region: PRK09077 405955007967 L-aspartate oxidase; Provisional; Region: PRK06175 405955007968 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 405955007969 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 405955007970 Methyltransferase domain; Region: Methyltransf_26; pfam13659 405955007971 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 405955007972 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405955007973 ATP binding site [chemical binding]; other site 405955007974 Mg++ binding site [ion binding]; other site 405955007975 motif III; other site 405955007976 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405955007977 nucleotide binding region [chemical binding]; other site 405955007978 ATP-binding site [chemical binding]; other site 405955007979 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405955007980 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955007981 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405955007982 dimerization interface [polypeptide binding]; other site 405955007983 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 405955007984 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 405955007985 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 405955007986 ligand binding site [chemical binding]; other site 405955007987 active site 405955007988 UGI interface [polypeptide binding]; other site 405955007989 catalytic site [active] 405955007990 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 405955007991 thioredoxin 2; Provisional; Region: PRK10996 405955007992 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 405955007993 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405955007994 catalytic residues [active] 405955007995 Uncharacterized conserved protein [Function unknown]; Region: COG3148 405955007996 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 405955007997 CoA binding domain; Region: CoA_binding_2; pfam13380 405955007998 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 405955007999 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 405955008000 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 405955008001 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 405955008002 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 405955008003 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 405955008004 domain interface [polypeptide binding]; other site 405955008005 putative active site [active] 405955008006 catalytic site [active] 405955008007 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 405955008008 domain interface [polypeptide binding]; other site 405955008009 putative active site [active] 405955008010 catalytic site [active] 405955008011 lipoprotein; Provisional; Region: PRK10759 405955008012 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 405955008013 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955008014 putative substrate translocation pore; other site 405955008015 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405955008016 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 405955008017 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405955008018 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405955008019 DNA binding residues [nucleotide binding] 405955008020 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 405955008021 Integrase core domain; Region: rve; pfam00665 405955008022 HTH-like domain; Region: HTH_21; pfam13276 405955008023 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: Tra5; COG2801 405955008024 Integrase core domain; Region: rve; pfam00665 405955008025 Integrase core domain; Region: rve_2; pfam13333 405955008026 Helix-turn-helix domain; Region: HTH_28; pfam13518 405955008027 protein disaggregation chaperone; Provisional; Region: PRK10865 405955008028 Clp amino terminal domain; Region: Clp_N; pfam02861 405955008029 Clp amino terminal domain; Region: Clp_N; pfam02861 405955008030 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955008031 Walker A motif; other site 405955008032 ATP binding site [chemical binding]; other site 405955008033 Walker B motif; other site 405955008034 arginine finger; other site 405955008035 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955008036 Walker A motif; other site 405955008037 ATP binding site [chemical binding]; other site 405955008038 Walker B motif; other site 405955008039 arginine finger; other site 405955008040 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 405955008041 hypothetical protein; Provisional; Region: PRK10723 405955008042 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 405955008043 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 405955008044 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405955008045 RNA binding surface [nucleotide binding]; other site 405955008046 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 405955008047 active site 405955008048 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 405955008049 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 405955008050 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 405955008051 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 405955008052 Prephenate dehydratase; Region: PDT; pfam00800 405955008053 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 405955008054 putative L-Phe binding site [chemical binding]; other site 405955008055 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 405955008056 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 405955008057 NADP oxidoreductase coenzyme F420-dependent; Region: F420_oxidored; cl17232 405955008058 prephenate dehydrogenase; Validated; Region: PRK08507 405955008059 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 405955008060 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 405955008061 lipoprotein; Provisional; Region: PRK11443 405955008062 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 405955008063 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 405955008064 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 405955008065 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955008066 metal binding site [ion binding]; metal-binding site 405955008067 active site 405955008068 I-site; other site 405955008069 putative outer membrane lipoprotein; Provisional; Region: PRK09967 405955008070 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405955008071 ligand binding site [chemical binding]; other site 405955008072 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 405955008073 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 405955008074 tRNA (Guanine-1)-methyltransferase; Region: tRNA_m1G_MT; cl00407 405955008075 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 405955008076 RimM N-terminal domain; Region: RimM; pfam01782 405955008077 PRC-barrel domain; Region: PRC; pfam05239 405955008078 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 405955008079 signal recognition particle protein; Provisional; Region: PRK10867 405955008080 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 405955008081 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 405955008082 P loop; other site 405955008083 GTP binding site [chemical binding]; other site 405955008084 Signal peptide binding domain; Region: SRP_SPB; pfam02978 405955008085 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 405955008086 hypothetical protein; Provisional; Region: PRK11573 405955008087 Domain of unknown function DUF21; Region: DUF21; pfam01595 405955008088 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405955008089 Transporter associated domain; Region: CorC_HlyC; smart01091 405955008090 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 405955008091 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 405955008092 recombination and repair protein; Provisional; Region: PRK10869 405955008093 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 405955008094 Walker A/P-loop; other site 405955008095 ATP binding site [chemical binding]; other site 405955008096 Q-loop/lid; other site 405955008097 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 405955008098 Q-loop/lid; other site 405955008099 ABC transporter signature motif; other site 405955008100 Walker B; other site 405955008101 D-loop; other site 405955008102 H-loop/switch region; other site 405955008103 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 405955008104 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 405955008105 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 405955008106 putative coenzyme Q binding site [chemical binding]; other site 405955008107 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 405955008108 SmpB-tmRNA interface; other site 405955008109 GIY-YIG domain of uncharacterized proteins from bacteria and their eukaryotic homologs; Region: GIY-YIG_COG3680; cd10440 405955008110 GIY-YIG motif/motif A; other site 405955008111 putative active site [active] 405955008112 putative metal binding site [ion binding]; other site 405955008113 Uncharacterized conserved protein [Function unknown]; Region: COG1479 405955008114 Protein of unknown function DUF262; Region: DUF262; pfam03235 405955008115 Protein of unknown function DUF262; Region: DUF262; pfam03235 405955008116 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 405955008117 Phage Tail Collar Domain; Region: Collar; pfam07484 405955008118 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 405955008119 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 405955008120 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 405955008121 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 405955008122 Phage protein GP46; Region: GP46; pfam07409 405955008123 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 405955008124 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 405955008125 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 405955008126 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 405955008127 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 405955008128 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 405955008129 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 405955008130 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 405955008131 Phage tail tube protein; Region: Tail_tube; pfam10618 405955008132 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 405955008133 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 405955008134 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 405955008135 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 405955008136 oligomerization interface [polypeptide binding]; other site 405955008137 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 405955008138 Phage capsid family; Region: Phage_capsid; pfam05065 405955008139 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 405955008140 Phage-related protein [Function unknown]; Region: COG4695 405955008141 Phage portal protein; Region: Phage_portal; pfam04860 405955008142 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 405955008143 Phage terminase, small subunit; Region: Terminase_4; pfam05119 405955008144 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 405955008145 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405955008146 active site 405955008147 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 405955008148 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 405955008149 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405955008150 catalytic residue [active] 405955008151 Antitermination protein; Region: Antiterm; pfam03589 405955008152 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 405955008153 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 405955008154 Zn binding sites [ion binding]; other site 405955008155 Antitermination protein; Region: Antiterm; pfam03589 405955008156 Protein of unknown function (DUF968); Region: DUF968; pfam06147 405955008157 KilA-N domain; Region: KilA-N; pfam04383 405955008158 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 405955008159 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 405955008160 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 405955008161 PerC transcriptional activator; Region: PerC; pfam06069 405955008162 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955008163 DNA-binding site [nucleotide binding]; DNA binding site 405955008164 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 405955008165 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 405955008166 Catalytic site [active] 405955008167 Uncharacterized conserved protein [Function unknown]; Region: COG5532 405955008168 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 405955008169 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 405955008170 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 405955008171 Int/Topo IB signature motif; other site 405955008172 Domain of unknown function (DUF4325); Region: DUF4325; pfam14213 405955008173 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 405955008174 substrate binding pocket [chemical binding]; other site 405955008175 active site 405955008176 iron coordination sites [ion binding]; other site 405955008177 Predicted dehydrogenase [General function prediction only]; Region: COG0579 405955008178 hydroxyglutarate oxidase; Provisional; Region: PRK11728 405955008179 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 405955008180 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 405955008181 tetramerization interface [polypeptide binding]; other site 405955008182 NAD(P) binding site [chemical binding]; other site 405955008183 catalytic residues [active] 405955008184 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 405955008185 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405955008186 inhibitor-cofactor binding pocket; inhibition site 405955008187 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955008188 catalytic residue [active] 405955008189 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 405955008190 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 405955008191 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955008192 DNA-binding site [nucleotide binding]; DNA binding site 405955008193 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 405955008194 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 405955008195 bacterial OsmY and nodulation domain; Region: BON; smart00749 405955008196 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405955008197 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405955008198 dimerization interface [polypeptide binding]; other site 405955008199 putative DNA binding site [nucleotide binding]; other site 405955008200 Transcriptional regulators [Transcription]; Region: MarR; COG1846 405955008201 putative Zn2+ binding site [ion binding]; other site 405955008202 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 405955008203 active site residue [active] 405955008204 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 405955008205 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 405955008206 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 405955008207 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 405955008208 hypothetical protein; Provisional; Region: PRK10556 405955008209 hypothetical protein; Provisional; Region: PRK10132 405955008210 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 405955008211 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955008212 DNA-binding site [nucleotide binding]; DNA binding site 405955008213 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405955008214 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955008215 homodimer interface [polypeptide binding]; other site 405955008216 catalytic residue [active] 405955008217 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 405955008218 Uncharacterized conserved protein [Function unknown]; Region: COG2128 405955008219 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 405955008220 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 405955008221 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 405955008222 Class I ribonucleotide reductase; Region: RNR_I; cd01679 405955008223 active site 405955008224 dimer interface [polypeptide binding]; other site 405955008225 catalytic residues [active] 405955008226 effector binding site; other site 405955008227 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 405955008228 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 405955008229 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 405955008230 dimer interface [polypeptide binding]; other site 405955008231 putative radical transfer pathway; other site 405955008232 diiron center [ion binding]; other site 405955008233 tyrosyl radical; other site 405955008234 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 405955008235 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 405955008236 Walker A/P-loop; other site 405955008237 ATP binding site [chemical binding]; other site 405955008238 Q-loop/lid; other site 405955008239 ABC transporter signature motif; other site 405955008240 Walker B; other site 405955008241 D-loop; other site 405955008242 H-loop/switch region; other site 405955008243 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 405955008244 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 405955008245 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955008246 dimer interface [polypeptide binding]; other site 405955008247 conserved gate region; other site 405955008248 putative PBP binding loops; other site 405955008249 ABC-ATPase subunit interface; other site 405955008250 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 405955008251 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 405955008252 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 405955008253 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955008254 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 405955008255 putative L-valine exporter; Provisional; Region: PRK10408 405955008256 transcriptional repressor MprA; Provisional; Region: PRK10870 405955008257 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405955008258 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 405955008259 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955008260 putative substrate translocation pore; other site 405955008261 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955008262 RNA ligase; Region: RNA_ligase; pfam09414 405955008263 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405955008264 Zn2+ binding site [ion binding]; other site 405955008265 Mg2+ binding site [ion binding]; other site 405955008266 AAA domain; Region: AAA_33; pfam13671 405955008267 S-ribosylhomocysteinase; Provisional; Region: PRK02260 405955008268 glutamate--cysteine ligase; Provisional; Region: PRK02107 405955008269 Predicted membrane protein [Function unknown]; Region: COG1238 405955008270 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 405955008271 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955008272 motif II; other site 405955008273 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 405955008274 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 405955008275 motif 1; other site 405955008276 active site 405955008277 motif 2; other site 405955008278 motif 3; other site 405955008279 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 405955008280 DHHA1 domain; Region: DHHA1; pfam02272 405955008281 recombination regulator RecX; Reviewed; Region: recX; PRK00117 405955008282 recombinase A; Provisional; Region: recA; PRK09354 405955008283 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 405955008284 hexamer interface [polypeptide binding]; other site 405955008285 Walker A motif; other site 405955008286 ATP binding site [chemical binding]; other site 405955008287 Walker B motif; other site 405955008288 hypothetical protein; Validated; Region: PRK03661 405955008289 Transglycosylase SLT domain; Region: SLT_2; pfam13406 405955008290 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405955008291 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405955008292 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 405955008293 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 405955008294 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 405955008295 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 405955008296 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 405955008297 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 405955008298 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 405955008299 putative NAD(P) binding site [chemical binding]; other site 405955008300 active site 405955008301 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 405955008302 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 405955008303 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 405955008304 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405955008305 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 405955008306 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 405955008307 putative active site [active] 405955008308 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 405955008309 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 405955008310 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405955008311 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955008312 Walker A motif; other site 405955008313 ATP binding site [chemical binding]; other site 405955008314 Walker B motif; other site 405955008315 arginine finger; other site 405955008316 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 405955008317 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405955008318 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 405955008319 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 405955008320 iron binding site [ion binding]; other site 405955008321 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 405955008322 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405955008323 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955008324 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 405955008325 Acylphosphatase; Region: Acylphosphatase; pfam00708 405955008326 HypF finger; Region: zf-HYPF; pfam07503 405955008327 HypF finger; Region: zf-HYPF; pfam07503 405955008328 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 405955008329 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 405955008330 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 405955008331 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405955008332 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955008333 DNA binding site [nucleotide binding] 405955008334 domain linker motif; other site 405955008335 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 405955008336 dimerization interface (closed form) [polypeptide binding]; other site 405955008337 ligand binding site [chemical binding]; other site 405955008338 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 405955008339 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405955008340 active site turn [active] 405955008341 phosphorylation site [posttranslational modification] 405955008342 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 405955008343 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 405955008344 beta-galactosidase; Region: BGL; TIGR03356 405955008345 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955008346 non-specific DNA binding site [nucleotide binding]; other site 405955008347 salt bridge; other site 405955008348 sequence-specific DNA binding site [nucleotide binding]; other site 405955008349 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 405955008350 nickel binding site [ion binding]; other site 405955008351 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 405955008352 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 405955008353 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 405955008354 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 405955008355 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 405955008356 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 405955008357 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 405955008358 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 405955008359 NADH dehydrogenase; Region: NADHdh; cl00469 405955008360 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 405955008361 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 405955008362 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 405955008363 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 405955008364 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 405955008365 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 405955008366 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 405955008367 hydrogenase assembly chaperone; Provisional; Region: PRK10409 405955008368 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 405955008369 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 405955008370 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 405955008371 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 405955008372 dimerization interface [polypeptide binding]; other site 405955008373 ATP binding site [chemical binding]; other site 405955008374 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 405955008375 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405955008376 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405955008377 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955008378 Walker A motif; other site 405955008379 ATP binding site [chemical binding]; other site 405955008380 Walker B motif; other site 405955008381 arginine finger; other site 405955008382 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405955008383 molybdenum-pterin binding domain; Region: Mop; TIGR00638 405955008384 Molybdopterin-binding protein [Coenzyme metabolism]; Region: MopI; COG3585 405955008385 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 405955008386 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 405955008387 MutS domain I; Region: MutS_I; pfam01624 405955008388 MutS domain II; Region: MutS_II; pfam05188 405955008389 MutS domain III; Region: MutS_III; pfam05192 405955008390 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 405955008391 Walker A/P-loop; other site 405955008392 ATP binding site [chemical binding]; other site 405955008393 Q-loop/lid; other site 405955008394 ABC transporter signature motif; other site 405955008395 Walker B; other site 405955008396 D-loop; other site 405955008397 H-loop/switch region; other site 405955008398 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 405955008399 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 405955008400 active site 405955008401 metal binding site [ion binding]; metal-binding site 405955008402 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405955008403 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 405955008404 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405955008405 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 405955008406 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405955008407 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 405955008408 putative aldolase; Validated; Region: PRK08130 405955008409 active site 405955008410 intersubunit interface [polypeptide binding]; other site 405955008411 Zn2+ binding site [ion binding]; other site 405955008412 hypothetical protein; Provisional; Region: PRK09989 405955008413 putative transporter; Provisional; Region: PRK09821 405955008414 GntP family permease; Region: GntP_permease; pfam02447 405955008415 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405955008416 Multimeric flavodoxin WrbA [General function prediction only]; Region: WrbA; COG0655 405955008417 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405955008418 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 405955008419 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 405955008420 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405955008421 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405955008422 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405955008423 DNA binding residues [nucleotide binding] 405955008424 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 405955008425 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405955008426 Peptidase family M23; Region: Peptidase_M23; pfam01551 405955008427 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 405955008428 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955008429 S-adenosylmethionine binding site [chemical binding]; other site 405955008430 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 405955008431 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 405955008432 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 405955008433 Permutation of conserved domain; other site 405955008434 active site 405955008435 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 405955008436 homotrimer interaction site [polypeptide binding]; other site 405955008437 zinc binding site [ion binding]; other site 405955008438 CDP-binding sites; other site 405955008439 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 405955008440 substrate binding site; other site 405955008441 dimer interface; other site 405955008442 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 405955008443 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 405955008444 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 405955008445 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 405955008446 ligand-binding site [chemical binding]; other site 405955008447 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 405955008448 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 405955008449 CysD dimerization site [polypeptide binding]; other site 405955008450 G1 box; other site 405955008451 putative GEF interaction site [polypeptide binding]; other site 405955008452 GTP/Mg2+ binding site [chemical binding]; other site 405955008453 Switch I region; other site 405955008454 G2 box; other site 405955008455 G3 box; other site 405955008456 Switch II region; other site 405955008457 G4 box; other site 405955008458 G5 box; other site 405955008459 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 405955008460 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 405955008461 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 405955008462 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 405955008463 Active Sites [active] 405955008464 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 405955008465 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 405955008466 metal binding site [ion binding]; metal-binding site 405955008467 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 405955008468 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 405955008469 Active Sites [active] 405955008470 sulfite reductase subunit beta; Provisional; Region: PRK13504 405955008471 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405955008472 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405955008473 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 405955008474 Flavodoxin; Region: Flavodoxin_1; pfam00258 405955008475 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 405955008476 FAD binding pocket [chemical binding]; other site 405955008477 FAD binding motif [chemical binding]; other site 405955008478 catalytic residues [active] 405955008479 NAD binding pocket [chemical binding]; other site 405955008480 phosphate binding motif [ion binding]; other site 405955008481 beta-alpha-beta structure motif; other site 405955008482 Tunnelling fold (T-fold). The five known T-folds are found in five different enzymes with different functions: dihydroneopterin-triphosphate epimerase (DHNTPE), dihydroneopterin aldolase (DHNA) , GTP cyclohydrolase I (GTPCH-1), 6-pyrovoyl...; Region: TFold; cl00263 405955008483 active site 405955008484 putative oxidoreductase FixC; Provisional; Region: PRK10157 405955008485 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 405955008486 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 405955008487 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 405955008488 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 405955008489 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 405955008490 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 405955008491 Ligand binding site [chemical binding]; other site 405955008492 Electron transfer flavoprotein domain; Region: ETF; pfam01012 405955008493 benzoate transport; Region: 2A0115; TIGR00895 405955008494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955008495 putative substrate translocation pore; other site 405955008496 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 405955008497 FAD binding domain; Region: FAD_binding_4; pfam01565 405955008498 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 405955008499 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 405955008500 NADP binding site [chemical binding]; other site 405955008501 homodimer interface [polypeptide binding]; other site 405955008502 active site 405955008503 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405955008504 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955008505 putative substrate translocation pore; other site 405955008506 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 405955008507 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 405955008508 nucleotide binding site [chemical binding]; other site 405955008509 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 405955008510 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 405955008511 Uncharacterized conserved protein [Function unknown]; Region: LemA; COG1704 405955008512 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 405955008513 Repair protein; Region: Repair_PSII; pfam04536 405955008514 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 405955008515 Repair protein; Region: Repair_PSII; pfam04536 405955008516 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 405955008517 Repair protein; Region: Repair_PSII; pfam04536 405955008518 enolase; Provisional; Region: eno; PRK00077 405955008519 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 405955008520 dimer interface [polypeptide binding]; other site 405955008521 metal binding site [ion binding]; metal-binding site 405955008522 substrate binding pocket [chemical binding]; other site 405955008523 CTP synthetase; Validated; Region: pyrG; PRK05380 405955008524 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 405955008525 Catalytic site [active] 405955008526 active site 405955008527 UTP binding site [chemical binding]; other site 405955008528 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 405955008529 active site 405955008530 putative oxyanion hole; other site 405955008531 catalytic triad [active] 405955008532 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 405955008533 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 405955008534 homodimer interface [polypeptide binding]; other site 405955008535 metal binding site [ion binding]; metal-binding site 405955008536 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 405955008537 homodimer interface [polypeptide binding]; other site 405955008538 active site 405955008539 putative chemical substrate binding site [chemical binding]; other site 405955008540 metal binding site [ion binding]; metal-binding site 405955008541 toxin MazF; Provisional; Region: PRK09907 405955008542 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 405955008543 HD domain; Region: HD_4; pfam13328 405955008544 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405955008545 synthetase active site [active] 405955008546 NTP binding site [chemical binding]; other site 405955008547 metal binding site [ion binding]; metal-binding site 405955008548 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 405955008549 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 405955008550 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 405955008551 TRAM domain; Region: TRAM; pfam01938 405955008552 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955008553 S-adenosylmethionine binding site [chemical binding]; other site 405955008554 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 405955008555 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 405955008556 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405955008557 dimerization interface [polypeptide binding]; other site 405955008558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955008559 dimer interface [polypeptide binding]; other site 405955008560 phosphorylation site [posttranslational modification] 405955008561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955008562 ATP binding site [chemical binding]; other site 405955008563 Mg2+ binding site [ion binding]; other site 405955008564 G-X-G motif; other site 405955008565 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 405955008566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955008567 active site 405955008568 phosphorylation site [posttranslational modification] 405955008569 intermolecular recognition site; other site 405955008570 dimerization interface [polypeptide binding]; other site 405955008571 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 405955008572 putative binding surface; other site 405955008573 active site 405955008574 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 405955008575 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 405955008576 active site 405955008577 tetramer interface [polypeptide binding]; other site 405955008578 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 405955008579 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 405955008580 active site 405955008581 tetramer interface [polypeptide binding]; other site 405955008582 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955008583 D-galactonate transporter; Region: 2A0114; TIGR00893 405955008584 putative substrate translocation pore; other site 405955008585 flavodoxin; Provisional; Region: PRK08105 405955008586 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 405955008587 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 405955008588 probable active site [active] 405955008589 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 405955008590 Syd protein (SUKH-2); Region: Syd; cl06405 405955008591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 405955008592 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 405955008593 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 405955008594 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 405955008595 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 405955008596 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 405955008597 serine transporter; Region: stp; TIGR00814 405955008598 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 405955008599 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 405955008600 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 405955008601 flap endonuclease-like protein; Provisional; Region: PRK09482 405955008602 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 405955008603 active site 405955008604 putative 5' ssDNA interaction site; other site 405955008605 metal binding site 3; metal-binding site 405955008606 metal binding site 1 [ion binding]; metal-binding site 405955008607 metal binding site 2 [ion binding]; metal-binding site 405955008608 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 405955008609 putative DNA binding site [nucleotide binding]; other site 405955008610 putative metal binding site [ion binding]; other site 405955008611 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 405955008612 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 405955008613 dimer interface [polypeptide binding]; other site 405955008614 active site 405955008615 metal binding site [ion binding]; metal-binding site 405955008616 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 405955008617 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 405955008618 intersubunit interface [polypeptide binding]; other site 405955008619 active site 405955008620 Zn2+ binding site [ion binding]; other site 405955008621 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 405955008622 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955008623 putative substrate translocation pore; other site 405955008624 L-fucose isomerase; Provisional; Region: fucI; PRK10991 405955008625 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 405955008626 hexamer (dimer of trimers) interface [polypeptide binding]; other site 405955008627 trimer interface [polypeptide binding]; other site 405955008628 substrate binding site [chemical binding]; other site 405955008629 Mn binding site [ion binding]; other site 405955008630 L-fuculokinase; Provisional; Region: PRK10331 405955008631 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 405955008632 nucleotide binding site [chemical binding]; other site 405955008633 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 405955008634 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 405955008635 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 405955008636 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405955008637 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 405955008638 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 405955008639 hypothetical protein; Provisional; Region: PRK10873 405955008640 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 405955008641 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955008642 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 405955008643 dimerization interface [polypeptide binding]; other site 405955008644 substrate binding pocket [chemical binding]; other site 405955008645 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 405955008646 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 405955008647 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405955008648 catalytic residue [active] 405955008649 CsdA-binding activator; Provisional; Region: PRK15019 405955008650 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 405955008651 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 405955008652 putative ATP binding site [chemical binding]; other site 405955008653 putative substrate interface [chemical binding]; other site 405955008654 murein transglycosylase A; Provisional; Region: mltA; PRK11162 405955008655 MltA specific insert domain; Region: MltA; pfam03562 405955008656 3D domain; Region: 3D; pfam06725 405955008657 Protein of unknown function (DUF770); Region: DUF770; pfam05591 405955008658 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3517; cl05484 405955008659 Protein of unknown function (DUF877); Region: DUF877; pfam05943 405955008660 type VI secretion protein, VC_A0114 family; Region: VI_chp_4; TIGR03353 405955008661 Bacterial protein of unknown function (DUF876); Region: DUF876; pfam05936 405955008662 type IV / VI secretion system protein, DotU family; Region: IV_VI_DotU; TIGR03349 405955008663 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 405955008664 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405955008665 ligand binding site [chemical binding]; other site 405955008666 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 405955008667 type VI secretion ATPase, ClpV1 family; Region: VI_ClpV1; TIGR03345 405955008668 Clp amino terminal domain; Region: Clp_N; pfam02861 405955008669 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955008670 Walker A motif; other site 405955008671 ATP binding site [chemical binding]; other site 405955008672 Walker B motif; other site 405955008673 arginine finger; other site 405955008674 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955008675 Walker A motif; other site 405955008676 ATP binding site [chemical binding]; other site 405955008677 Walker B motif; other site 405955008678 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 405955008679 Rhs element Vgr protein; Region: vgr_GE; TIGR01646 405955008680 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 405955008681 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 405955008682 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 405955008683 Uncharacterized protein conserved in bacteria (DUF2345); Region: DUF2345; pfam10106 405955008684 PGAP1-like protein; Region: PGAP1; pfam07819 405955008685 Type VI protein secretion system component VasK [Intracellular trafficking, secretion, and vesicular transport]; Region: IcmF; COG3523 405955008686 Intracellular multiplication and human macrophage-killing; Region: IcmF-related; pfam06761 405955008687 Protein of unknown function (DUF1215); Region: DUF1215; pfam06744 405955008688 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 405955008689 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 405955008690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955008691 Walker A motif; other site 405955008692 ATP binding site [chemical binding]; other site 405955008693 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405955008694 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405955008695 DNA binding residues [nucleotide binding] 405955008696 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 405955008697 Integrase core domain; Region: rve; pfam00665 405955008698 Predicted component of the type VI protein secretion system [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3515 405955008699 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 405955008700 type VI secretion-associated protein, VC_A0119 family; Region: VI_chp_7; TIGR03362 405955008701 PAAR motif; Region: PAAR_motif; pfam05488 405955008702 Type VI protein secretion system component VasA [Intracellular trafficking, secretion, and vesicular transport]; Region: COG3519 405955008703 Bacterial protein of unknown function (DUF879); Region: DUF879; pfam05947 405955008704 Protein of unknown function (DUF1305); Region: DUF1305; pfam06996 405955008705 Type VI secretion lipoprotein; Region: T6SS-SciN; pfam12790 405955008706 type VI secretion system lysozyme-like protein; Region: VI_zyme; TIGR03357 405955008707 ImpA-related N-terminal; Region: ImpA-rel_N; pfam06812 405955008708 ImpA domain protein; Region: DUF3702; pfam12486 405955008709 Putative D-3-Phosphoglycerate Dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_like_2; cd12172 405955008710 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 405955008711 putative ligand binding site [chemical binding]; other site 405955008712 putative NAD binding site [chemical binding]; other site 405955008713 catalytic site [active] 405955008714 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 405955008715 putative active site [active] 405955008716 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 405955008717 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405955008718 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955008719 homodimer interface [polypeptide binding]; other site 405955008720 catalytic residue [active] 405955008721 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 405955008722 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405955008723 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405955008724 active site turn [active] 405955008725 phosphorylation site [posttranslational modification] 405955008726 CAT RNA binding domain; Region: CAT_RBD; pfam03123 405955008727 PRD domain; Region: PRD; pfam00874 405955008728 PRD domain; Region: PRD; pfam00874 405955008729 AMIN domain; Region: AMIN; pfam11741 405955008730 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405955008731 active site 405955008732 metal binding site [ion binding]; metal-binding site 405955008733 N-acetylglutamate synthase; Validated; Region: PRK05279 405955008734 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 405955008735 putative nucleotide binding site [chemical binding]; other site 405955008736 putative substrate binding site [chemical binding]; other site 405955008737 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405955008738 Coenzyme A binding pocket [chemical binding]; other site 405955008739 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 405955008740 AAA domain; Region: AAA_30; pfam13604 405955008741 Family description; Region: UvrD_C_2; pfam13538 405955008742 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 405955008743 protease3; Provisional; Region: PRK15101 405955008744 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 405955008745 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405955008746 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405955008747 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 405955008748 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 405955008749 hypothetical protein; Provisional; Region: PRK10332 405955008750 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 405955008751 hypothetical protein; Provisional; Region: PRK11521 405955008752 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 405955008753 hypothetical protein; Provisional; Region: PRK10557 405955008754 hypothetical protein; Provisional; Region: PRK10506 405955008755 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 405955008756 thymidylate synthase; Reviewed; Region: thyA; PRK01827 405955008757 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 405955008758 dimerization interface [polypeptide binding]; other site 405955008759 active site 405955008760 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 405955008761 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 405955008762 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 405955008763 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 405955008764 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405955008765 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 405955008766 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 405955008767 putative active site [active] 405955008768 Ap4A binding site [chemical binding]; other site 405955008769 nudix motif; other site 405955008770 putative metal binding site [ion binding]; other site 405955008771 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 405955008772 putative DNA-binding cleft [nucleotide binding]; other site 405955008773 putative DNA clevage site; other site 405955008774 molecular lever; other site 405955008775 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 405955008776 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405955008777 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405955008778 active site 405955008779 catalytic tetrad [active] 405955008780 lysophospholipid transporter LplT; Provisional; Region: PRK11195 405955008781 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955008782 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 405955008783 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 405955008784 putative acyl-acceptor binding pocket; other site 405955008785 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 405955008786 acyl-activating enzyme (AAE) consensus motif; other site 405955008787 putative AMP binding site [chemical binding]; other site 405955008788 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 405955008789 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955008790 DNA binding site [nucleotide binding] 405955008791 domain linker motif; other site 405955008792 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 405955008793 dimerization interface (closed form) [polypeptide binding]; other site 405955008794 ligand binding site [chemical binding]; other site 405955008795 diaminopimelate decarboxylase; Provisional; Region: PRK11165 405955008796 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 405955008797 active site 405955008798 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405955008799 substrate binding site [chemical binding]; other site 405955008800 catalytic residues [active] 405955008801 dimer interface [polypeptide binding]; other site 405955008802 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 405955008803 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955008804 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 405955008805 dimerization interface [polypeptide binding]; other site 405955008806 putative racemase; Provisional; Region: PRK10200 405955008807 aspartate racemase; Region: asp_race; TIGR00035 405955008808 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 405955008809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955008810 putative substrate translocation pore; other site 405955008811 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955008812 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 405955008813 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 405955008814 NADP binding site [chemical binding]; other site 405955008815 homodimer interface [polypeptide binding]; other site 405955008816 active site 405955008817 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 405955008818 putative acyltransferase; Provisional; Region: PRK05790 405955008819 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405955008820 dimer interface [polypeptide binding]; other site 405955008821 active site 405955008822 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 405955008823 serine transporter; Region: stp; TIGR00814 405955008824 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 405955008825 Peptidase family M23; Region: Peptidase_M23; pfam01551 405955008826 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 405955008827 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 405955008828 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 405955008829 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 405955008830 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 405955008831 GAF domain; Region: GAF; cl17456 405955008832 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 405955008833 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405955008834 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955008835 Walker A motif; other site 405955008836 ATP binding site [chemical binding]; other site 405955008837 Walker B motif; other site 405955008838 arginine finger; other site 405955008839 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405955008840 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 405955008841 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405955008842 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405955008843 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 405955008844 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 405955008845 catalytic residue [active] 405955008846 peptidase; Reviewed; Region: PRK13004 405955008847 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 405955008848 putative metal binding site [ion binding]; other site 405955008849 putative dimer interface [polypeptide binding]; other site 405955008850 D-hydantoinase; Region: D-hydantoinase; TIGR02033 405955008851 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 405955008852 tetramer interface [polypeptide binding]; other site 405955008853 active site 405955008854 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 405955008855 carbamate kinase; Reviewed; Region: PRK12686 405955008856 putative substrate binding site [chemical binding]; other site 405955008857 homodimer interface [polypeptide binding]; other site 405955008858 nucleotide binding site [chemical binding]; other site 405955008859 nucleotide binding site [chemical binding]; other site 405955008860 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 405955008861 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 405955008862 XdhC Rossmann domain; Region: XdhC_C; pfam13478 405955008863 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 405955008864 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 405955008865 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 405955008866 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 405955008867 Ligand binding site; other site 405955008868 metal-binding site 405955008869 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 405955008870 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 405955008871 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405955008872 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 405955008873 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 405955008874 active site 405955008875 putative substrate binding pocket [chemical binding]; other site 405955008876 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 405955008877 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 405955008878 putative hypoxanthine oxidase; Provisional; Region: PRK09800 405955008879 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 405955008880 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 405955008881 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 405955008882 uracil-xanthine permease; Region: ncs2; TIGR00801 405955008883 guanine deaminase; Provisional; Region: PRK09228 405955008884 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 405955008885 active site 405955008886 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405955008887 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 405955008888 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 405955008889 4Fe-4S binding domain; Region: Fer4; pfam00037 405955008890 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 405955008891 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955008892 xanthine permease; Region: pbuX; TIGR03173 405955008893 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 405955008894 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 405955008895 active site 405955008896 metal binding site [ion binding]; metal-binding site 405955008897 nudix motif; other site 405955008898 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 405955008899 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 405955008900 dimer interface [polypeptide binding]; other site 405955008901 putative anticodon binding site; other site 405955008902 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 405955008903 motif 1; other site 405955008904 active site 405955008905 motif 2; other site 405955008906 motif 3; other site 405955008907 peptide chain release factor 2; Provisional; Region: PRK08787 405955008908 This domain is found in peptide chain release factors; Region: PCRF; smart00937 405955008909 RF-1 domain; Region: RF-1; pfam00472 405955008910 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 405955008911 DHH family; Region: DHH; pfam01368 405955008912 DHHA1 domain; Region: DHHA1; pfam02272 405955008913 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 405955008914 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 405955008915 dimerization domain [polypeptide binding]; other site 405955008916 dimer interface [polypeptide binding]; other site 405955008917 catalytic residues [active] 405955008918 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 405955008919 tyrosine recombinase XerD; Region: recomb_XerD; TIGR02225 405955008920 active site 405955008921 Int/Topo IB signature motif; other site 405955008922 flavodoxin FldB; Provisional; Region: PRK12359 405955008923 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 405955008924 hypothetical protein; Provisional; Region: PRK10878 405955008925 putative global regulator; Reviewed; Region: PRK09559 405955008926 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 405955008927 hemolysin; Provisional; Region: PRK15087 405955008928 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 405955008929 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 405955008930 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 405955008931 beta-galactosidase; Region: BGL; TIGR03356 405955008932 glycine dehydrogenase; Provisional; Region: PRK05367 405955008933 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 405955008934 tetramer interface [polypeptide binding]; other site 405955008935 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955008936 catalytic residue [active] 405955008937 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 405955008938 tetramer interface [polypeptide binding]; other site 405955008939 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955008940 catalytic residue [active] 405955008941 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 405955008942 lipoyl attachment site [posttranslational modification]; other site 405955008943 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 405955008944 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 405955008945 oxidoreductase; Provisional; Region: PRK08013 405955008946 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 405955008947 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 405955008948 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 405955008949 proline aminopeptidase P II; Provisional; Region: PRK10879 405955008950 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 405955008951 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 405955008952 active site 405955008953 hypothetical protein; Reviewed; Region: PRK01736 405955008954 Z-ring-associated protein; Provisional; Region: PRK10972 405955008955 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 405955008956 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 405955008957 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 405955008958 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 405955008959 ligand binding site [chemical binding]; other site 405955008960 NAD binding site [chemical binding]; other site 405955008961 tetramer interface [polypeptide binding]; other site 405955008962 catalytic site [active] 405955008963 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 405955008964 L-serine binding site [chemical binding]; other site 405955008965 ACT domain interface; other site 405955008966 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 405955008967 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405955008968 active site 405955008969 dimer interface [polypeptide binding]; other site 405955008970 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 405955008971 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955008972 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 405955008973 putative dimerization interface [polypeptide binding]; other site 405955008974 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM)-like family; contains proteins similar to MCM, and the large subunit of Streptomyces coenzyme B12-dependent isobutyryl-CoA mutase (ICM). MCM catalyzes the isomerization of...; Region: MM_CoA_mutase; cl00817 405955008975 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955008976 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405955008977 oxidative stress defense protein; Provisional; Region: PRK11087 405955008978 Uncharacterized conserved protein [Function unknown]; Region: COG2968 405955008979 arginine exporter protein; Provisional; Region: PRK09304 405955008980 mechanosensitive channel MscS; Provisional; Region: PRK10334 405955008981 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405955008982 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 405955008983 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 405955008984 active site 405955008985 intersubunit interface [polypeptide binding]; other site 405955008986 zinc binding site [ion binding]; other site 405955008987 Na+ binding site [ion binding]; other site 405955008988 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 405955008989 Phosphoglycerate kinase; Region: PGK; pfam00162 405955008990 substrate binding site [chemical binding]; other site 405955008991 hinge regions; other site 405955008992 ADP binding site [chemical binding]; other site 405955008993 catalytic site [active] 405955008994 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 405955008995 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 405955008996 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 405955008997 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 405955008998 trimer interface [polypeptide binding]; other site 405955008999 putative Zn binding site [ion binding]; other site 405955009000 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 405955009001 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405955009002 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405955009003 Walker A/P-loop; other site 405955009004 ATP binding site [chemical binding]; other site 405955009005 Q-loop/lid; other site 405955009006 ABC transporter signature motif; other site 405955009007 Walker B; other site 405955009008 D-loop; other site 405955009009 H-loop/switch region; other site 405955009010 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 405955009011 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 405955009012 Walker A/P-loop; other site 405955009013 ATP binding site [chemical binding]; other site 405955009014 Q-loop/lid; other site 405955009015 ABC transporter signature motif; other site 405955009016 Walker B; other site 405955009017 D-loop; other site 405955009018 H-loop/switch region; other site 405955009019 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 405955009020 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 405955009021 active site 405955009022 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 405955009023 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 405955009024 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 405955009025 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405955009026 putative NAD(P) binding site [chemical binding]; other site 405955009027 catalytic Zn binding site [ion binding]; other site 405955009028 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 405955009029 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 405955009030 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 405955009031 active site 405955009032 P-loop; other site 405955009033 phosphorylation site [posttranslational modification] 405955009034 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405955009035 active site 405955009036 phosphorylation site [posttranslational modification] 405955009037 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 405955009038 SPFH domain / Band 7 family; Region: Band_7; pfam01145 405955009039 transketolase; Reviewed; Region: PRK12753 405955009040 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 405955009041 TPP-binding site [chemical binding]; other site 405955009042 dimer interface [polypeptide binding]; other site 405955009043 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405955009044 PYR/PP interface [polypeptide binding]; other site 405955009045 dimer interface [polypeptide binding]; other site 405955009046 TPP binding site [chemical binding]; other site 405955009047 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405955009048 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 405955009049 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 405955009050 agmatinase; Region: agmatinase; TIGR01230 405955009051 oligomer interface [polypeptide binding]; other site 405955009052 putative active site [active] 405955009053 Mn binding site [ion binding]; other site 405955009054 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 405955009055 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 405955009056 dimer interface [polypeptide binding]; other site 405955009057 active site 405955009058 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405955009059 catalytic residues [active] 405955009060 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 405955009061 S-adenosylmethionine synthetase; Validated; Region: PRK05250 405955009062 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 405955009063 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 405955009064 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 405955009065 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 405955009066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955009067 putative substrate translocation pore; other site 405955009068 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955009069 hypothetical protein; Provisional; Region: PRK04860 405955009070 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 405955009071 DNA-specific endonuclease I; Provisional; Region: PRK15137 405955009072 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 405955009073 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 405955009074 RNA methyltransferase, RsmE family; Region: TIGR00046 405955009075 glutathione synthetase; Provisional; Region: PRK05246 405955009076 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 405955009077 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 405955009078 hypothetical protein; Validated; Region: PRK00228 405955009079 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 405955009080 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 405955009081 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 405955009082 Walker A motif; other site 405955009083 ATP binding site [chemical binding]; other site 405955009084 Walker B motif; other site 405955009085 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 405955009086 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405955009087 catalytic residue [active] 405955009088 YGGT family; Region: YGGT; pfam02325 405955009089 YGGT family; Region: YGGT; pfam02325 405955009090 hypothetical protein; Validated; Region: PRK05090 405955009091 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 405955009092 active site 405955009093 dimerization interface [polypeptide binding]; other site 405955009094 HemN family oxidoreductase; Provisional; Region: PRK05660 405955009095 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955009096 FeS/SAM binding site; other site 405955009097 HemN C-terminal domain; Region: HemN_C; pfam06969 405955009098 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 405955009099 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 405955009100 homodimer interface [polypeptide binding]; other site 405955009101 active site 405955009102 hypothetical protein; Provisional; Region: PRK10626 405955009103 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 405955009104 hypothetical protein; Provisional; Region: PRK11702 405955009105 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 405955009106 adenine DNA glycosylase; Provisional; Region: PRK10880 405955009107 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 405955009108 minor groove reading motif; other site 405955009109 helix-hairpin-helix signature motif; other site 405955009110 substrate binding pocket [chemical binding]; other site 405955009111 active site 405955009112 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 405955009113 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 405955009114 DNA binding and oxoG recognition site [nucleotide binding] 405955009115 oxidative damage protection protein; Provisional; Region: PRK05408 405955009116 murein transglycosylase C; Provisional; Region: mltC; PRK11671 405955009117 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 405955009118 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405955009119 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405955009120 catalytic residue [active] 405955009121 nucleoside transporter; Region: 2A0110; TIGR00889 405955009122 ornithine decarboxylase; Provisional; Region: PRK13578 405955009123 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 405955009124 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 405955009125 homodimer interface [polypeptide binding]; other site 405955009126 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955009127 catalytic residue [active] 405955009128 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405955009129 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 405955009130 integrase; Provisional; Region: PRK09692 405955009131 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 405955009132 active site 405955009133 Int/Topo IB signature motif; other site 405955009134 Part of AAA domain; Region: AAA_19; pfam13245 405955009135 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 405955009136 AAA domain; Region: AAA_12; pfam13087 405955009137 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 405955009138 putative active site [active] 405955009139 catalytic site [active] 405955009140 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 405955009141 Sulfatase; Region: Sulfatase; cl17466 405955009142 Opacity protein and related surface antigens [Cell envelope biogenesis, outer membrane]; Region: COG3637 405955009143 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 405955009144 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 405955009145 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955009146 Walker A motif; other site 405955009147 ATP binding site [chemical binding]; other site 405955009148 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405955009149 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405955009150 DNA binding residues [nucleotide binding] 405955009151 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 405955009152 Integrase core domain; Region: rve; pfam00665 405955009153 PapG carbohydrate / receptor binding domain (CBD); PapG, the adhesin of the P-pili, is situated at the tip, mediating the attachment of uropathogenic Escherichia coli to the uroepithelium of the human kidney; PapG has a two-domain architecture: a...; Region: PapG_CBD; cd00239 405955009154 putative membrane interaction site; other site 405955009155 receptor/carbohydrate binding site; other site 405955009156 PapG chaperone-binding domain; Region: PapG_C; pfam03628 405955009157 Fimbrial protein; Region: Fimbrial; pfam00419 405955009158 Fimbrial protein; Region: Fimbrial; pfam00419 405955009159 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 405955009160 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 405955009161 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 405955009162 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 405955009163 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 405955009164 PapC N-terminal domain; Region: PapC_N; pfam13954 405955009165 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 405955009166 PapC C-terminal domain; Region: PapC_C; pfam13953 405955009167 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 405955009168 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 405955009169 Adhesin biosynthesis transcription regulatory protein; Region: PapB; pfam03333 405955009170 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 405955009171 Transposase; Region: HTH_Tnp_1; cl17663 405955009172 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405955009173 HTH-like domain; Region: HTH_21; pfam13276 405955009174 Integrase core domain; Region: rve; pfam00665 405955009175 Sugar phosphate permease [Carbohydrate transport and metabolism]; Region: UhpC; COG2271 405955009176 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955009177 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955009178 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 405955009179 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 405955009180 Signal transduction histidine kinase regulating phosphoglycerate transport system [Signal transduction mechanisms]; Region: COG4192 405955009181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955009182 dimer interface [polypeptide binding]; other site 405955009183 phosphorylation site [posttranslational modification] 405955009184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955009185 ATP binding site [chemical binding]; other site 405955009186 G-X-G motif; other site 405955009187 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 405955009188 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955009189 active site 405955009190 phosphorylation site [posttranslational modification] 405955009191 intermolecular recognition site; other site 405955009192 dimerization interface [polypeptide binding]; other site 405955009193 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405955009194 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405955009195 PerC transcriptional activator; Region: PerC; pfam06069 405955009196 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 405955009197 ParB-like nuclease domain; Region: ParB; smart00470 405955009198 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 405955009199 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 405955009200 Active Sites [active] 405955009201 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 405955009202 AAA domain; Region: AAA_21; pfam13304 405955009203 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955009204 Walker B; other site 405955009205 D-loop; other site 405955009206 H-loop/switch region; other site 405955009207 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 405955009208 putative active site [active] 405955009209 putative metal-binding site [ion binding]; other site 405955009210 putative transposase OrfB; Reviewed; Region: PHA02517 405955009211 HTH-like domain; Region: HTH_21; pfam13276 405955009212 Integrase core domain; Region: rve; pfam00665 405955009213 Integrase core domain; Region: rve_3; pfam13683 405955009214 Transposase; Region: HTH_Tnp_1; cl17663 405955009215 putative iron-regulated outer membrane virulence protein; Provisional; Region: PRK13484 405955009216 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 405955009217 N-terminal plug; other site 405955009218 ligand-binding site [chemical binding]; other site 405955009219 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 405955009220 Predicted GTPase [General function prediction only]; Region: COG3596 405955009221 YfjP GTPase; Region: YfjP; cd11383 405955009222 G1 box; other site 405955009223 GTP/Mg2+ binding site [chemical binding]; other site 405955009224 Switch I region; other site 405955009225 G2 box; other site 405955009226 Switch II region; other site 405955009227 G3 box; other site 405955009228 G4 box; other site 405955009229 G5 box; other site 405955009230 HTH domain; Region: HTH_11; cl17392 405955009231 WYL domain; Region: WYL; pfam13280 405955009232 Domain of unknown function (DUF932); Region: DUF932; pfam06067 405955009233 Antirestriction protein; Region: Antirestrict; pfam03230 405955009234 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 405955009235 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 405955009236 MPN+ (JAMM) motif; other site 405955009237 Zinc-binding site [ion binding]; other site 405955009238 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 405955009239 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 405955009240 Methyltransferase domain; Region: Methyltransf_27; pfam13708 405955009241 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 405955009242 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 405955009243 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955009244 KpsF/GutQ family protein; Region: kpsF; TIGR00393 405955009245 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 405955009246 putative active site [active] 405955009247 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 405955009248 polysaccharide export inner-membrane protein, BexC/CtrB/KpsE family; Region: BexC_CtrB_KpsE; TIGR01010 405955009249 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 405955009250 Periplasmic protein involved in polysaccharide export, contains SLBB domain of b-grasp fold [Cell wall/membrane/envelope biogenesis]; Region: Wza; COG1596 405955009251 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 405955009252 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 405955009253 Ligand binding site; other site 405955009254 oligomer interface; other site 405955009255 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsC; COG3563 405955009256 Capsule polysaccharide export protein [Cell envelope biogenesis, outer membrane]; Region: KpsS; COG3562 405955009257 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 405955009258 Alpha-2,8-polysialyltransferase (POLYST); Region: A-2_8-polyST; pfam07388 405955009259 Capsule polysaccharide biosynthesis protein; Region: Capsule_synth; pfam05159 405955009260 UDP-N-acetyl-D-glucosamine 2-epimerase, UDP-hydrolysing; Region: NeuC_NnaA; TIGR03568 405955009261 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 405955009262 active site 405955009263 homodimer interface [polypeptide binding]; other site 405955009264 CMP-NeuAc_Synthase activates N-acetylneuraminic acid by adding CMP moiety; Region: CMP-NeuAc_Synthase; cd02513 405955009265 ligand binding site; other site 405955009266 tetramer interface; other site 405955009267 NnaC (CMP-NeuNAc synthetase) _like subfamily of SGNH_hydrolases, a diverse family of lipases and esterases. The tertiary fold of the enzyme is substantially different from that of the alpha/beta hydrolase family and unique among all known hydrolases; its...; Region: NnaC_like; cd01841 405955009268 active site 405955009269 catalytic triad [active] 405955009270 oxyanion hole [active] 405955009271 N-acetylneuraminate synthase; Region: NeuB_NnaB; TIGR03569 405955009272 NeuB family; Region: NeuB; pfam03102 405955009273 C-terminal SAF domain of sialic acid synthetase; Region: SAF_NeuB_like; cd11615 405955009274 NeuB binding interface [polypeptide binding]; other site 405955009275 putative substrate binding site [chemical binding]; other site 405955009276 Putative Acyltransferase (AT), Left-handed parallel beta-Helix (LbH) domain; This group is composed of mostly uncharacterized proteins containing an N-terminal helical subdomain followed by a LbH domain. The alignment contains 6 turns, each containing...; Region: LbH_AT_putative; cd03360 405955009277 sugar O-acyltransferase, sialic acid O-acetyltransferase NeuD family; Region: NeuD_NnaD; TIGR03570 405955009278 putative trimer interface [polypeptide binding]; other site 405955009279 putative CoA binding site [chemical binding]; other site 405955009280 ABC-type antimicrobial peptide transport system, ATPase component [Defense mechanisms]; Region: SalX; COG1136 405955009281 ATP-binding cassette component of polysaccharide transport system; Region: ABC_KpsT_Wzt; cd03220 405955009282 Walker A/P-loop; other site 405955009283 ATP binding site [chemical binding]; other site 405955009284 Q-loop/lid; other site 405955009285 ABC transporter signature motif; other site 405955009286 Walker B; other site 405955009287 D-loop; other site 405955009288 H-loop/switch region; other site 405955009289 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405955009290 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 405955009291 GspL-like protein; Provisional; Region: PRK09662 405955009292 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 405955009293 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 405955009294 type II secretion system protein J; Region: gspJ; TIGR01711 405955009295 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 405955009296 type II secretion system protein I; Region: gspI; TIGR01707 405955009297 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 405955009298 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 405955009299 Type II transport protein GspH; Region: GspH; pfam12019 405955009300 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 405955009301 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 405955009302 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 405955009303 type II secretion system protein F; Region: GspF; TIGR02120 405955009304 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 405955009305 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 405955009306 type II secretion system protein E; Region: type_II_gspE; TIGR02533 405955009307 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 405955009308 Walker A motif; other site 405955009309 ATP binding site [chemical binding]; other site 405955009310 Walker B motif; other site 405955009311 type II secretion system protein D; Region: type_II_gspD; TIGR02517 405955009312 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 405955009313 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 405955009314 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 405955009315 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 405955009316 putative type II secretion protein GspC; Provisional; Region: PRK09681 405955009317 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 405955009318 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405955009319 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 405955009320 Bacterial Peptidase A24 N-terminal domain; Region: DiS_P_DiS; pfam06750 405955009321 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 405955009322 Domain of unknown function (DUF4092); Region: DUF4092; pfam13322 405955009323 Peptidase M60-like family; Region: M60-like; pfam13402 405955009324 glycolate transporter; Provisional; Region: PRK09695 405955009325 L-lactate permease; Region: Lactate_perm; cl00701 405955009326 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 405955009327 active site 405955009328 hypothetical protein; Provisional; Region: PRK09732 405955009329 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 405955009330 FAD binding domain; Region: FAD_binding_4; pfam01565 405955009331 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 405955009332 FAD binding domain; Region: FAD_binding_4; pfam01565 405955009333 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 405955009334 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955009335 DNA-binding site [nucleotide binding]; DNA binding site 405955009336 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 405955009337 acyl-CoA synthetase; Validated; Region: PRK09192 405955009338 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 405955009339 acyl-activating enzyme (AAE) consensus motif; other site 405955009340 active site 405955009341 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 405955009342 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405955009343 NAD(P) binding site [chemical binding]; other site 405955009344 active site 405955009345 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 405955009346 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405955009347 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405955009348 catalytic residue [active] 405955009349 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 405955009350 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 405955009351 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 405955009352 Predicted permeases [General function prediction only]; Region: COG0795 405955009353 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 405955009354 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405955009355 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 405955009356 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 405955009357 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 405955009358 active site 405955009359 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 405955009360 TMP-binding site; other site 405955009361 ATP-binding site [chemical binding]; other site 405955009362 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 405955009363 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 405955009364 TMP-binding site; other site 405955009365 ATP-binding site [chemical binding]; other site 405955009366 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 405955009367 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 405955009368 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 405955009369 CHAP domain; Region: CHAP; pfam05257 405955009370 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 405955009371 putative S-transferase; Provisional; Region: PRK11752 405955009372 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 405955009373 C-terminal domain interface [polypeptide binding]; other site 405955009374 GSH binding site (G-site) [chemical binding]; other site 405955009375 dimer interface [polypeptide binding]; other site 405955009376 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 405955009377 dimer interface [polypeptide binding]; other site 405955009378 N-terminal domain interface [polypeptide binding]; other site 405955009379 active site 405955009380 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 405955009381 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 405955009382 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 405955009383 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 405955009384 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 405955009385 putative substrate-binding site; other site 405955009386 nickel binding site [ion binding]; other site 405955009387 hydrogenase 2 large subunit; Provisional; Region: PRK10467 405955009388 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 405955009389 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 405955009390 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 405955009391 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 405955009392 4Fe-4S binding domain; Region: Fer4_6; pfam12837 405955009393 hydrogenase 2 small subunit; Provisional; Region: PRK10468 405955009394 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 405955009395 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 405955009396 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 405955009397 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 405955009398 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405955009399 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405955009400 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405955009401 active site 405955009402 catalytic tetrad [active] 405955009403 hypothetical protein; Provisional; Region: PRK05208 405955009404 oxidoreductase; Provisional; Region: PRK07985 405955009405 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 405955009406 NAD binding site [chemical binding]; other site 405955009407 metal binding site [ion binding]; metal-binding site 405955009408 active site 405955009409 biopolymer transport protein ExbD; Provisional; Region: PRK11267 405955009410 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 405955009411 biopolymer transport protein ExbB; Provisional; Region: PRK10414 405955009412 cystathionine beta-lyase; Provisional; Region: PRK08114 405955009413 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405955009414 homodimer interface [polypeptide binding]; other site 405955009415 substrate-cofactor binding pocket; other site 405955009416 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955009417 catalytic residue [active] 405955009418 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405955009419 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 405955009420 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 405955009421 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 405955009422 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955009423 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955009424 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 405955009425 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 405955009426 dimer interface [polypeptide binding]; other site 405955009427 active site 405955009428 metal binding site [ion binding]; metal-binding site 405955009429 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 405955009430 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 405955009431 active site 405955009432 catalytic tetrad [active] 405955009433 putative outer membrane lipoprotein; Provisional; Region: PRK09973 405955009434 hypothetical protein; Provisional; Region: PRK01254 405955009435 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 405955009436 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 405955009437 Transcriptional regulators [Transcription]; Region: FadR; COG2186 405955009438 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955009439 DNA-binding site [nucleotide binding]; DNA binding site 405955009440 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 405955009441 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 405955009442 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 405955009443 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 405955009444 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405955009445 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 405955009446 putative NAD(P) binding site [chemical binding]; other site 405955009447 catalytic Zn binding site [ion binding]; other site 405955009448 structural Zn binding site [ion binding]; other site 405955009449 Malate/L-lactate dehydrogenases [Energy production and conversion]; Region: COG2055 405955009450 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 405955009451 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 405955009452 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 405955009453 DctM-like transporters; Region: DctM; pfam06808 405955009454 TRAP transporter, DctM subunit; Region: dctM; TIGR00786 405955009455 FtsI repressor; Provisional; Region: PRK10883 405955009456 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 405955009457 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 405955009458 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 405955009459 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 405955009460 putative acyl-acceptor binding pocket; other site 405955009461 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 405955009462 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 405955009463 CAP-like domain; other site 405955009464 active site 405955009465 primary dimer interface [polypeptide binding]; other site 405955009466 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 405955009467 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 405955009468 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 405955009469 peptide binding site [polypeptide binding]; other site 405955009470 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 405955009471 TIGR00156 family protein; Region: TIGR00156 405955009472 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 405955009473 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955009474 active site 405955009475 phosphorylation site [posttranslational modification] 405955009476 intermolecular recognition site; other site 405955009477 dimerization interface [polypeptide binding]; other site 405955009478 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955009479 DNA binding site [nucleotide binding] 405955009480 sensor protein QseC; Provisional; Region: PRK10337 405955009481 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955009482 dimer interface [polypeptide binding]; other site 405955009483 phosphorylation site [posttranslational modification] 405955009484 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955009485 ATP binding site [chemical binding]; other site 405955009486 Mg2+ binding site [ion binding]; other site 405955009487 G-X-G motif; other site 405955009488 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 405955009489 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 405955009490 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 405955009491 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 405955009492 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cd04795 405955009493 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 405955009494 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 405955009495 siderophore binding site; other site 405955009496 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 405955009497 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955009498 ABC-ATPase subunit interface; other site 405955009499 dimer interface [polypeptide binding]; other site 405955009500 putative PBP binding regions; other site 405955009501 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405955009502 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955009503 dimer interface [polypeptide binding]; other site 405955009504 putative PBP binding regions; other site 405955009505 ABC-ATPase subunit interface; other site 405955009506 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405955009507 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405955009508 Walker A/P-loop; other site 405955009509 ATP binding site [chemical binding]; other site 405955009510 Q-loop/lid; other site 405955009511 ABC transporter signature motif; other site 405955009512 Walker B; other site 405955009513 D-loop; other site 405955009514 H-loop/switch region; other site 405955009515 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 405955009516 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 405955009517 N-terminal plug; other site 405955009518 ligand-binding site [chemical binding]; other site 405955009519 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 405955009520 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955009521 ATP binding site [chemical binding]; other site 405955009522 Mg2+ binding site [ion binding]; other site 405955009523 G-X-G motif; other site 405955009524 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 405955009525 anchoring element; other site 405955009526 dimer interface [polypeptide binding]; other site 405955009527 ATP binding site [chemical binding]; other site 405955009528 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 405955009529 active site 405955009530 metal binding site [ion binding]; metal-binding site 405955009531 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 405955009532 esterase YqiA; Provisional; Region: PRK11071 405955009533 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405955009534 Predicted phosphohydrolases [General function prediction only]; Region: Icc; COG1409 405955009535 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 405955009536 hexamer interface [polypeptide binding]; other site 405955009537 active site 405955009538 metal binding site [ion binding]; metal-binding site 405955009539 putative dehydrogenase; Provisional; Region: PRK11039 405955009540 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 405955009541 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 405955009542 dimer interface [polypeptide binding]; other site 405955009543 ADP-ribose binding site [chemical binding]; other site 405955009544 active site 405955009545 nudix motif; other site 405955009546 metal binding site [ion binding]; metal-binding site 405955009547 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 405955009548 hypothetical protein; Provisional; Region: PRK11653 405955009549 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 405955009550 Arylsulfotransferase (ASST); Region: Arylsulfotrans; pfam05935 405955009551 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 405955009552 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 405955009553 catalytic residues [active] 405955009554 hinge region; other site 405955009555 alpha helical domain; other site 405955009556 putative disulfide oxidoreductase; Provisional; Region: PRK04307 405955009557 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 405955009558 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 405955009559 putative active site [active] 405955009560 metal binding site [ion binding]; metal-binding site 405955009561 zinc transporter ZupT; Provisional; Region: PRK04201 405955009562 ZIP Zinc transporter; Region: Zip; pfam02535 405955009563 putative fimbrial protein; Provisional; Region: PRK09733 405955009564 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 405955009565 PapC N-terminal domain; Region: PapC_N; pfam13954 405955009566 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 405955009567 PapC C-terminal domain; Region: PapC_C; pfam13953 405955009568 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 405955009569 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 405955009570 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 405955009571 Fimbrial protein; Region: Fimbrial; pfam00419 405955009572 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 405955009573 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 405955009574 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 405955009575 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 405955009576 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 405955009577 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 405955009578 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 405955009579 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 405955009580 putative ribose interaction site [chemical binding]; other site 405955009581 putative ADP binding site [chemical binding]; other site 405955009582 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 405955009583 active site 405955009584 nucleotide binding site [chemical binding]; other site 405955009585 HIGH motif; other site 405955009586 KMSKS motif; other site 405955009587 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 405955009588 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 405955009589 metal binding triad; other site 405955009590 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 405955009591 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 405955009592 metal binding triad; other site 405955009593 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 405955009594 Uncharacterized conserved protein [Function unknown]; Region: COG3025 405955009595 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 405955009596 putative active site [active] 405955009597 putative metal binding residues [ion binding]; other site 405955009598 signature motif; other site 405955009599 putative triphosphate binding site [ion binding]; other site 405955009600 CHAD domain; Region: CHAD; pfam05235 405955009601 SH3 domain-containing protein; Provisional; Region: PRK10884 405955009602 Bacterial SH3 domain homologues; Region: SH3b; smart00287 405955009603 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 405955009604 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 405955009605 active site 405955009606 NTP binding site [chemical binding]; other site 405955009607 metal binding triad [ion binding]; metal-binding site 405955009608 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 405955009609 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405955009610 Zn2+ binding site [ion binding]; other site 405955009611 Mg2+ binding site [ion binding]; other site 405955009612 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 405955009613 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 405955009614 homooctamer interface [polypeptide binding]; other site 405955009615 active site 405955009616 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 405955009617 transcriptional activator TtdR; Provisional; Region: PRK09801 405955009618 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955009619 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 405955009620 putative effector binding pocket; other site 405955009621 putative dimerization interface [polypeptide binding]; other site 405955009622 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 405955009623 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 405955009624 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 405955009625 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 405955009626 transmembrane helices; other site 405955009627 UGMP family protein; Validated; Region: PRK09604 405955009628 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 405955009629 DNA primase; Validated; Region: dnaG; PRK05667 405955009630 CHC2 zinc finger; Region: zf-CHC2; pfam01807 405955009631 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 405955009632 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 405955009633 active site 405955009634 metal binding site [ion binding]; metal-binding site 405955009635 interdomain interaction site; other site 405955009636 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 405955009637 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 405955009638 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 405955009639 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 405955009640 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 405955009641 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 405955009642 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405955009643 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 405955009644 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405955009645 DNA binding residues [nucleotide binding] 405955009646 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 405955009647 active site 405955009648 SUMO-1 interface [polypeptide binding]; other site 405955009649 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 405955009650 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 405955009651 FAD binding pocket [chemical binding]; other site 405955009652 FAD binding motif [chemical binding]; other site 405955009653 phosphate binding motif [ion binding]; other site 405955009654 NAD binding pocket [chemical binding]; other site 405955009655 Predicted transcriptional regulators [Transcription]; Region: COG1695 405955009656 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 405955009657 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405955009658 PAS fold; Region: PAS_3; pfam08447 405955009659 putative active site [active] 405955009660 heme pocket [chemical binding]; other site 405955009661 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 405955009662 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 405955009663 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405955009664 dimer interface [polypeptide binding]; other site 405955009665 putative CheW interface [polypeptide binding]; other site 405955009666 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 405955009667 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405955009668 inhibitor-cofactor binding pocket; inhibition site 405955009669 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955009670 catalytic residue [active] 405955009671 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 405955009672 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955009673 DNA binding site [nucleotide binding] 405955009674 domain linker motif; other site 405955009675 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 405955009676 putative dimerization interface [polypeptide binding]; other site 405955009677 putative ligand binding site [chemical binding]; other site 405955009678 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 405955009679 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 405955009680 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 405955009681 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 405955009682 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 405955009683 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 405955009684 inner membrane transporter YjeM; Provisional; Region: PRK15238 405955009685 alpha-glucosidase; Provisional; Region: PRK10137 405955009686 Protein of unknown function, DUF608; Region: DUF608; pfam04685 405955009687 Trehalase; Region: Trehalase; cl17346 405955009688 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 405955009689 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 405955009690 active site 405955009691 FMN binding site [chemical binding]; other site 405955009692 2,4-decadienoyl-CoA binding site; other site 405955009693 catalytic residue [active] 405955009694 4Fe-4S cluster binding site [ion binding]; other site 405955009695 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 405955009696 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 405955009697 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955009698 S-adenosylmethionine binding site [chemical binding]; other site 405955009699 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 405955009700 putative active site [active] 405955009701 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 405955009702 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405955009703 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 405955009704 serine/threonine transporter SstT; Provisional; Region: PRK13628 405955009705 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405955009706 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 405955009707 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 405955009708 galactarate dehydratase; Region: galactar-dH20; TIGR03248 405955009709 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 405955009710 Glucuronate isomerase; Region: UxaC; pfam02614 405955009711 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 405955009712 D-galactonate transporter; Region: 2A0114; TIGR00893 405955009713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955009714 putative substrate translocation pore; other site 405955009715 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 405955009716 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955009717 DNA-binding site [nucleotide binding]; DNA binding site 405955009718 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 405955009719 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 405955009720 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 405955009721 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 405955009722 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 405955009723 Predicted membrane protein [Function unknown]; Region: COG5393 405955009724 YqjK-like protein; Region: YqjK; pfam13997 405955009725 Predicted membrane protein [Function unknown]; Region: COG2259 405955009726 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 405955009727 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 405955009728 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 405955009729 putative dimer interface [polypeptide binding]; other site 405955009730 N-terminal domain interface [polypeptide binding]; other site 405955009731 putative substrate binding pocket (H-site) [chemical binding]; other site 405955009732 Predicted membrane protein [Function unknown]; Region: COG3152 405955009733 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955009734 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 405955009735 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 405955009736 dimerization interface [polypeptide binding]; other site 405955009737 Pirin-related protein [General function prediction only]; Region: COG1741 405955009738 Pirin; Region: Pirin; pfam02678 405955009739 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 405955009740 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 405955009741 serine transporter; Region: stp; TIGR00814 405955009742 L-serine dehydratase TdcG; Provisional; Region: PRK15040 405955009743 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 405955009744 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 405955009745 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 405955009746 homotrimer interaction site [polypeptide binding]; other site 405955009747 putative active site [active] 405955009748 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 405955009749 Pyruvate formate lyase 1; Region: PFL1; cd01678 405955009750 coenzyme A binding site [chemical binding]; other site 405955009751 active site 405955009752 catalytic residues [active] 405955009753 glycine loop; other site 405955009754 propionate/acetate kinase; Provisional; Region: PRK12379 405955009755 Acetokinase family; Region: Acetate_kinase; cl17229 405955009756 threonine/serine transporter TdcC; Provisional; Region: PRK13629 405955009757 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 405955009758 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 405955009759 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 405955009760 tetramer interface [polypeptide binding]; other site 405955009761 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955009762 catalytic residue [active] 405955009763 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 405955009764 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955009765 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 405955009766 putative substrate binding pocket [chemical binding]; other site 405955009767 putative dimerization interface [polypeptide binding]; other site 405955009768 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 405955009769 glycerate kinase I; Provisional; Region: PRK10342 405955009770 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 405955009771 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405955009772 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 405955009773 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955009774 D-galactonate transporter; Region: 2A0114; TIGR00893 405955009775 putative substrate translocation pore; other site 405955009776 galactarate dehydratase; Region: galactar-dH20; TIGR03248 405955009777 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 405955009778 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 405955009779 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 405955009780 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 405955009781 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405955009782 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 405955009783 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 405955009784 active site 405955009785 phosphorylation site [posttranslational modification] 405955009786 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 405955009787 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 405955009788 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 405955009789 active pocket/dimerization site; other site 405955009790 active site 405955009791 phosphorylation site [posttranslational modification] 405955009792 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 405955009793 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 405955009794 active site 405955009795 dimer interface [polypeptide binding]; other site 405955009796 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 405955009797 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 405955009798 dimer interface [polypeptide binding]; other site 405955009799 active site 405955009800 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 405955009801 putative active site [active] 405955009802 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 405955009803 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 405955009804 active site 405955009805 intersubunit interface [polypeptide binding]; other site 405955009806 zinc binding site [ion binding]; other site 405955009807 Na+ binding site [ion binding]; other site 405955009808 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 405955009809 active site 405955009810 phosphorylation site [posttranslational modification] 405955009811 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 405955009812 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 405955009813 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 405955009814 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 405955009815 active site 405955009816 trimer interface [polypeptide binding]; other site 405955009817 allosteric site; other site 405955009818 active site lid [active] 405955009819 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 405955009820 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 405955009821 putative SAM binding site [chemical binding]; other site 405955009822 putative homodimer interface [polypeptide binding]; other site 405955009823 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 405955009824 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 405955009825 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 405955009826 putative ligand binding site [chemical binding]; other site 405955009827 TIGR00252 family protein; Region: TIGR00252 405955009828 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 405955009829 dimer interface [polypeptide binding]; other site 405955009830 active site 405955009831 outer membrane lipoprotein; Provisional; Region: PRK11023 405955009832 BON domain; Region: BON; pfam04972 405955009833 BON domain; Region: BON; pfam04972 405955009834 Predicted permease; Region: DUF318; pfam03773 405955009835 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 405955009836 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405955009837 NAD binding site [chemical binding]; other site 405955009838 active site 405955009839 intracellular protease, PfpI family; Region: PfpI; TIGR01382 405955009840 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 405955009841 proposed catalytic triad [active] 405955009842 conserved cys residue [active] 405955009843 hypothetical protein; Provisional; Region: PRK03467 405955009844 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 405955009845 GIY-YIG motif/motif A; other site 405955009846 putative active site [active] 405955009847 putative metal binding site [ion binding]; other site 405955009848 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405955009849 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405955009850 Coenzyme A binding pocket [chemical binding]; other site 405955009851 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 405955009852 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 405955009853 Peptidase family U32; Region: Peptidase_U32; pfam01136 405955009854 putative protease; Provisional; Region: PRK15447 405955009855 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 405955009856 hypothetical protein; Provisional; Region: PRK10508 405955009857 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 405955009858 tryptophan permease; Provisional; Region: PRK10483 405955009859 aromatic amino acid transport protein; Region: araaP; TIGR00837 405955009860 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 405955009861 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405955009862 ATP binding site [chemical binding]; other site 405955009863 Mg++ binding site [ion binding]; other site 405955009864 motif III; other site 405955009865 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405955009866 nucleotide binding region [chemical binding]; other site 405955009867 ATP-binding site [chemical binding]; other site 405955009868 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 405955009869 putative RNA binding site [nucleotide binding]; other site 405955009870 lipoprotein NlpI; Provisional; Region: PRK11189 405955009871 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405955009872 binding surface 405955009873 TPR motif; other site 405955009874 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 405955009875 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 405955009876 RNase E interface [polypeptide binding]; other site 405955009877 trimer interface [polypeptide binding]; other site 405955009878 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 405955009879 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 405955009880 RNase E interface [polypeptide binding]; other site 405955009881 trimer interface [polypeptide binding]; other site 405955009882 active site 405955009883 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 405955009884 putative nucleic acid binding region [nucleotide binding]; other site 405955009885 G-X-X-G motif; other site 405955009886 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 405955009887 RNA binding site [nucleotide binding]; other site 405955009888 domain interface; other site 405955009889 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 405955009890 16S/18S rRNA binding site [nucleotide binding]; other site 405955009891 S13e-L30e interaction site [polypeptide binding]; other site 405955009892 25S rRNA binding site [nucleotide binding]; other site 405955009893 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 405955009894 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 405955009895 RNA binding site [nucleotide binding]; other site 405955009896 active site 405955009897 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 405955009898 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 405955009899 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 405955009900 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 405955009901 translation initiation factor IF-2; Region: IF-2; TIGR00487 405955009902 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 405955009903 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 405955009904 G1 box; other site 405955009905 putative GEF interaction site [polypeptide binding]; other site 405955009906 GTP/Mg2+ binding site [chemical binding]; other site 405955009907 Switch I region; other site 405955009908 G2 box; other site 405955009909 G3 box; other site 405955009910 Switch II region; other site 405955009911 G4 box; other site 405955009912 G5 box; other site 405955009913 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 405955009914 Translation-initiation factor 2; Region: IF-2; pfam11987 405955009915 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 405955009916 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 405955009917 NusA N-terminal domain; Region: NusA_N; pfam08529 405955009918 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 405955009919 RNA binding site [nucleotide binding]; other site 405955009920 homodimer interface [polypeptide binding]; other site 405955009921 NusA-like KH domain; Region: KH_5; pfam13184 405955009922 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 405955009923 G-X-X-G motif; other site 405955009924 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 405955009925 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 405955009926 ribosome maturation protein RimP; Reviewed; Region: PRK00092 405955009927 Sm and related proteins; Region: Sm_like; cl00259 405955009928 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 405955009929 putative oligomer interface [polypeptide binding]; other site 405955009930 putative RNA binding site [nucleotide binding]; other site 405955009931 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 405955009932 ANP binding site [chemical binding]; other site 405955009933 Substrate Binding Site II [chemical binding]; other site 405955009934 Substrate Binding Site I [chemical binding]; other site 405955009935 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 405955009936 Sulfatase; Region: Sulfatase; pfam00884 405955009937 Preprotein translocase SecG subunit; Region: SecG; pfam03840 405955009938 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 405955009939 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 405955009940 active site 405955009941 substrate binding site [chemical binding]; other site 405955009942 metal binding site [ion binding]; metal-binding site 405955009943 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 405955009944 dihydropteroate synthase; Region: DHPS; TIGR01496 405955009945 substrate binding pocket [chemical binding]; other site 405955009946 dimer interface [polypeptide binding]; other site 405955009947 inhibitor binding site; inhibition site 405955009948 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 405955009949 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955009950 Walker A motif; other site 405955009951 ATP binding site [chemical binding]; other site 405955009952 Walker B motif; other site 405955009953 arginine finger; other site 405955009954 Peptidase family M41; Region: Peptidase_M41; pfam01434 405955009955 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 405955009956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955009957 S-adenosylmethionine binding site [chemical binding]; other site 405955009958 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 405955009959 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 405955009960 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 405955009961 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 405955009962 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 405955009963 GTPase CgtA; Reviewed; Region: obgE; PRK12298 405955009964 GTP1/OBG; Region: GTP1_OBG; pfam01018 405955009965 Obg GTPase; Region: Obg; cd01898 405955009966 G1 box; other site 405955009967 GTP/Mg2+ binding site [chemical binding]; other site 405955009968 Switch I region; other site 405955009969 G2 box; other site 405955009970 G3 box; other site 405955009971 Switch II region; other site 405955009972 G4 box; other site 405955009973 G5 box; other site 405955009974 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405955009975 EamA-like transporter family; Region: EamA; pfam00892 405955009976 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 405955009977 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 405955009978 substrate binding pocket [chemical binding]; other site 405955009979 chain length determination region; other site 405955009980 substrate-Mg2+ binding site; other site 405955009981 catalytic residues [active] 405955009982 aspartate-rich region 1; other site 405955009983 active site lid residues [active] 405955009984 aspartate-rich region 2; other site 405955009985 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 405955009986 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 405955009987 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 405955009988 hinge; other site 405955009989 active site 405955009990 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 405955009991 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 405955009992 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 405955009993 mce related protein; Region: MCE; pfam02470 405955009994 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 405955009995 conserved hypothetical integral membrane protein; Region: TIGR00056 405955009996 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 405955009997 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 405955009998 Walker A/P-loop; other site 405955009999 ATP binding site [chemical binding]; other site 405955010000 Q-loop/lid; other site 405955010001 ABC transporter signature motif; other site 405955010002 Walker B; other site 405955010003 D-loop; other site 405955010004 H-loop/switch region; other site 405955010005 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 405955010006 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 405955010007 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 405955010008 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 405955010009 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 405955010010 putative active site [active] 405955010011 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 405955010012 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 405955010013 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 405955010014 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 405955010015 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 405955010016 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 405955010017 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 405955010018 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 405955010019 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 405955010020 Walker A/P-loop; other site 405955010021 ATP binding site [chemical binding]; other site 405955010022 Q-loop/lid; other site 405955010023 ABC transporter signature motif; other site 405955010024 Walker B; other site 405955010025 D-loop; other site 405955010026 H-loop/switch region; other site 405955010027 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 405955010028 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 405955010029 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 405955010030 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 405955010031 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 405955010032 30S subunit binding site; other site 405955010033 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405955010034 active site 405955010035 phosphorylation site [posttranslational modification] 405955010036 P-loop ATPase protein family; Region: ATP_bind_2; cl15794 405955010037 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405955010038 dimerization domain swap beta strand [polypeptide binding]; other site 405955010039 regulatory protein interface [polypeptide binding]; other site 405955010040 active site 405955010041 regulatory phosphorylation site [posttranslational modification]; other site 405955010042 hypothetical protein; Provisional; Region: PRK10345 405955010043 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 405955010044 Transglycosylase; Region: Transgly; cl17702 405955010045 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 405955010046 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 405955010047 conserved cys residue [active] 405955010048 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 405955010049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405955010050 putative active site [active] 405955010051 heme pocket [chemical binding]; other site 405955010052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955010053 dimer interface [polypeptide binding]; other site 405955010054 phosphorylation site [posttranslational modification] 405955010055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955010056 ATP binding site [chemical binding]; other site 405955010057 Mg2+ binding site [ion binding]; other site 405955010058 G-X-G motif; other site 405955010059 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955010060 active site 405955010061 phosphorylation site [posttranslational modification] 405955010062 intermolecular recognition site; other site 405955010063 dimerization interface [polypeptide binding]; other site 405955010064 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 405955010065 putative binding surface; other site 405955010066 active site 405955010067 radical SAM protein, TIGR01212 family; Region: TIGR01212 405955010068 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955010069 FeS/SAM binding site; other site 405955010070 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 405955010071 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 405955010072 active site 405955010073 dimer interface [polypeptide binding]; other site 405955010074 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 405955010075 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 405955010076 active site 405955010077 FMN binding site [chemical binding]; other site 405955010078 substrate binding site [chemical binding]; other site 405955010079 3Fe-4S cluster binding site [ion binding]; other site 405955010080 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 405955010081 domain interface; other site 405955010082 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 405955010083 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405955010084 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955010085 Domain of unknown function (DUF386); Region: DUF386; cl01047 405955010086 N-acetylmannosamine kinase; Provisional; Region: PRK05082 405955010087 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405955010088 nucleotide binding site [chemical binding]; other site 405955010089 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 405955010090 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 405955010091 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 405955010092 putative active site cavity [active] 405955010093 putative sialic acid transporter; Provisional; Region: PRK03893 405955010094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955010095 putative substrate translocation pore; other site 405955010096 N-acetylneuraminate lyase; Region: nanA; TIGR00683 405955010097 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 405955010098 inhibitor site; inhibition site 405955010099 active site 405955010100 dimer interface [polypeptide binding]; other site 405955010101 catalytic residue [active] 405955010102 transcriptional regulator NanR; Provisional; Region: PRK03837 405955010103 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955010104 DNA-binding site [nucleotide binding]; DNA binding site 405955010105 FCD domain; Region: FCD; pfam07729 405955010106 Stringent starvation protein B [General function prediction only]; Region: SspB; COG2969 405955010107 stringent starvation protein A; Provisional; Region: sspA; PRK09481 405955010108 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 405955010109 C-terminal domain interface [polypeptide binding]; other site 405955010110 putative GSH binding site (G-site) [chemical binding]; other site 405955010111 dimer interface [polypeptide binding]; other site 405955010112 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 405955010113 dimer interface [polypeptide binding]; other site 405955010114 N-terminal domain interface [polypeptide binding]; other site 405955010115 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 405955010116 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 405955010117 23S rRNA interface [nucleotide binding]; other site 405955010118 L3 interface [polypeptide binding]; other site 405955010119 Predicted ATPase [General function prediction only]; Region: COG1485 405955010120 serine endoprotease; Provisional; Region: PRK10139 405955010121 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 405955010122 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405955010123 protein binding site [polypeptide binding]; other site 405955010124 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405955010125 serine endoprotease; Provisional; Region: PRK10898 405955010126 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 405955010127 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 405955010128 malate dehydrogenase; Provisional; Region: PRK05086 405955010129 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 405955010130 NAD binding site [chemical binding]; other site 405955010131 dimerization interface [polypeptide binding]; other site 405955010132 Substrate binding site [chemical binding]; other site 405955010133 arginine repressor; Provisional; Region: PRK05066 405955010134 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 405955010135 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 405955010136 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 405955010137 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 405955010138 RNAase interaction site [polypeptide binding]; other site 405955010139 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 405955010140 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 405955010141 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 405955010142 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955010143 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955010144 efflux system membrane protein; Provisional; Region: PRK11594 405955010145 transcriptional regulator; Provisional; Region: PRK10632 405955010146 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955010147 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 405955010148 putative effector binding pocket; other site 405955010149 dimerization interface [polypeptide binding]; other site 405955010150 protease TldD; Provisional; Region: tldD; PRK10735 405955010151 hypothetical protein; Provisional; Region: PRK10899 405955010152 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 405955010153 ribonuclease G; Provisional; Region: PRK11712 405955010154 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 405955010155 homodimer interface [polypeptide binding]; other site 405955010156 oligonucleotide binding site [chemical binding]; other site 405955010157 Maf-like protein; Region: Maf; pfam02545 405955010158 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 405955010159 active site 405955010160 dimer interface [polypeptide binding]; other site 405955010161 rod shape-determining protein MreD; Provisional; Region: PRK11060 405955010162 rod shape-determining protein MreC; Region: mreC; TIGR00219 405955010163 rod shape-determining protein MreC; Region: MreC; pfam04085 405955010164 rod shape-determining protein MreB; Provisional; Region: PRK13927 405955010165 MreB and similar proteins; Region: MreB_like; cd10225 405955010166 nucleotide binding site [chemical binding]; other site 405955010167 Mg binding site [ion binding]; other site 405955010168 putative protofilament interaction site [polypeptide binding]; other site 405955010169 RodZ interaction site [polypeptide binding]; other site 405955010170 regulatory protein CsrD; Provisional; Region: PRK11059 405955010171 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955010172 metal binding site [ion binding]; metal-binding site 405955010173 active site 405955010174 I-site; other site 405955010175 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955010176 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 405955010177 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 405955010178 NADP binding site [chemical binding]; other site 405955010179 dimer interface [polypeptide binding]; other site 405955010180 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 405955010181 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 405955010182 carboxyltransferase (CT) interaction site; other site 405955010183 biotinylation site [posttranslational modification]; other site 405955010184 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 405955010185 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 405955010186 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 405955010187 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 405955010188 Aldose 1-epimerase, similar to Escherichia coli c4013; Region: Aldose_epim_Ec_c4013; cd09023 405955010189 active site 405955010190 catalytic residues [active] 405955010191 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405955010192 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 405955010193 substrate binding site [chemical binding]; other site 405955010194 ATP binding site [chemical binding]; other site 405955010195 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405955010196 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405955010197 TM-ABC transporter signature motif; other site 405955010198 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 405955010199 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405955010200 Walker A/P-loop; other site 405955010201 ATP binding site [chemical binding]; other site 405955010202 Q-loop/lid; other site 405955010203 ABC transporter signature motif; other site 405955010204 Walker B; other site 405955010205 D-loop; other site 405955010206 H-loop/switch region; other site 405955010207 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405955010208 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 405955010209 Periplasmic sugar-binding domain of uncharacterized ABC-type transport systems; Region: PBP1_ABC_sugar_binding_like_12; cd06322 405955010210 putative ligand binding site [chemical binding]; other site 405955010211 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 405955010212 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 405955010213 intersubunit interface [polypeptide binding]; other site 405955010214 active site 405955010215 zinc binding site [ion binding]; other site 405955010216 Na+ binding site [ion binding]; other site 405955010217 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405955010218 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 405955010219 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405955010220 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 405955010221 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405955010222 substrate binding site [chemical binding]; other site 405955010223 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405955010224 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 405955010225 ATP binding site [chemical binding]; other site 405955010226 substrate binding site [chemical binding]; other site 405955010227 hypothetical protein; Provisional; Region: PRK10633 405955010228 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 405955010229 Na binding site [ion binding]; other site 405955010230 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 405955010231 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 405955010232 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 405955010233 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 405955010234 FMN binding site [chemical binding]; other site 405955010235 active site 405955010236 catalytic residues [active] 405955010237 substrate binding site [chemical binding]; other site 405955010238 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 405955010239 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 405955010240 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 405955010241 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955010242 DNA methylase; Region: N6_N4_Mtase; pfam01555 405955010243 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 405955010244 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955010245 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 405955010246 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 405955010247 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955010248 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955010249 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 405955010250 Protein export membrane protein; Region: SecD_SecF; cl14618 405955010251 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 405955010252 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955010253 substrate binding pocket [chemical binding]; other site 405955010254 membrane-bound complex binding site; other site 405955010255 hinge residues; other site 405955010256 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 405955010257 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955010258 conserved gate region; other site 405955010259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955010260 dimer interface [polypeptide binding]; other site 405955010261 conserved gate region; other site 405955010262 putative PBP binding loops; other site 405955010263 ABC-ATPase subunit interface; other site 405955010264 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 405955010265 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955010266 dimer interface [polypeptide binding]; other site 405955010267 conserved gate region; other site 405955010268 putative PBP binding loops; other site 405955010269 ABC-ATPase subunit interface; other site 405955010270 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 405955010271 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 405955010272 Walker A/P-loop; other site 405955010273 ATP binding site [chemical binding]; other site 405955010274 Q-loop/lid; other site 405955010275 ABC transporter signature motif; other site 405955010276 Walker B; other site 405955010277 D-loop; other site 405955010278 H-loop/switch region; other site 405955010279 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 405955010280 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 405955010281 trimer interface [polypeptide binding]; other site 405955010282 putative metal binding site [ion binding]; other site 405955010283 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 405955010284 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 405955010285 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 405955010286 shikimate binding site; other site 405955010287 NAD(P) binding site [chemical binding]; other site 405955010288 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 405955010289 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405955010290 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 405955010291 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405955010292 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 405955010293 hypothetical protein; Validated; Region: PRK03430 405955010294 hypothetical protein; Provisional; Region: PRK10736 405955010295 DNA protecting protein DprA; Region: dprA; TIGR00732 405955010296 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 405955010297 active site 405955010298 catalytic residues [active] 405955010299 metal binding site [ion binding]; metal-binding site 405955010300 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 405955010301 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 405955010302 putative active site [active] 405955010303 substrate binding site [chemical binding]; other site 405955010304 putative cosubstrate binding site; other site 405955010305 catalytic site [active] 405955010306 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 405955010307 substrate binding site [chemical binding]; other site 405955010308 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 405955010309 putative RNA binding site [nucleotide binding]; other site 405955010310 16S rRNA methyltransferase B; Provisional; Region: PRK10901 405955010311 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955010312 S-adenosylmethionine binding site [chemical binding]; other site 405955010313 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 405955010314 TrkA-N domain; Region: TrkA_N; pfam02254 405955010315 TrkA-C domain; Region: TrkA_C; pfam02080 405955010316 TrkA-N domain; Region: TrkA_N; pfam02254 405955010317 TrkA-C domain; Region: TrkA_C; pfam02080 405955010318 Large-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscL; COG1970 405955010319 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 405955010320 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 405955010321 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 405955010322 DNA binding residues [nucleotide binding] 405955010323 dimer interface [polypeptide binding]; other site 405955010324 metal binding site [ion binding]; metal-binding site 405955010325 hypothetical protein; Provisional; Region: PRK10203 405955010326 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 405955010327 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 405955010328 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 405955010329 alphaNTD homodimer interface [polypeptide binding]; other site 405955010330 alphaNTD - beta interaction site [polypeptide binding]; other site 405955010331 alphaNTD - beta' interaction site [polypeptide binding]; other site 405955010332 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 405955010333 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 405955010334 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 405955010335 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405955010336 RNA binding surface [nucleotide binding]; other site 405955010337 30S ribosomal protein S11; Validated; Region: PRK05309 405955010338 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 405955010339 30S ribosomal protein S13; Region: bact_S13; TIGR03631 405955010340 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 405955010341 SecY translocase; Region: SecY; pfam00344 405955010342 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 405955010343 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 405955010344 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 405955010345 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 405955010346 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 405955010347 23S rRNA interface [nucleotide binding]; other site 405955010348 5S rRNA interface [nucleotide binding]; other site 405955010349 L27 interface [polypeptide binding]; other site 405955010350 L5 interface [polypeptide binding]; other site 405955010351 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 405955010352 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 405955010353 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 405955010354 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 405955010355 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 405955010356 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 405955010357 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 405955010358 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 405955010359 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 405955010360 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 405955010361 RNA binding site [nucleotide binding]; other site 405955010362 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 405955010363 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 405955010364 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 405955010365 23S rRNA interface [nucleotide binding]; other site 405955010366 5S rRNA interface [nucleotide binding]; other site 405955010367 putative antibiotic binding site [chemical binding]; other site 405955010368 L25 interface [polypeptide binding]; other site 405955010369 L27 interface [polypeptide binding]; other site 405955010370 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 405955010371 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 405955010372 G-X-X-G motif; other site 405955010373 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 405955010374 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 405955010375 protein-rRNA interface [nucleotide binding]; other site 405955010376 putative translocon binding site; other site 405955010377 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 405955010378 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 405955010379 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 405955010380 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 405955010381 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 405955010382 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 405955010383 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 405955010384 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 405955010385 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 405955010386 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 405955010387 type II secretion system protein D; Region: type_II_gspD; TIGR02517 405955010388 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 405955010389 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 405955010390 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 405955010391 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 405955010392 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 405955010393 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 405955010394 Walker A motif; other site 405955010395 ATP binding site [chemical binding]; other site 405955010396 Walker B motif; other site 405955010397 type II secretion system protein F; Region: GspF; TIGR02120 405955010398 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 405955010399 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 405955010400 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 405955010401 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 405955010402 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 405955010403 Type II transport protein GspH; Region: GspH; pfam12019 405955010404 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 405955010405 type II secretion system protein I; Region: gspI; TIGR01707 405955010406 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 405955010407 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 405955010408 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 405955010409 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 405955010410 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 405955010411 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 405955010412 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 405955010413 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 405955010414 GspL periplasmic domain; Region: GspL_C; pfam12693 405955010415 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 405955010416 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 405955010417 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 405955010418 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 405955010419 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 405955010420 heme binding site [chemical binding]; other site 405955010421 ferroxidase pore; other site 405955010422 ferroxidase diiron center [ion binding]; other site 405955010423 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 405955010424 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 405955010425 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 405955010426 aromatic chitin/cellulose binding site residues [chemical binding]; other site 405955010427 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 405955010428 active site 405955010429 elongation factor Tu; Reviewed; Region: PRK00049 405955010430 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 405955010431 G1 box; other site 405955010432 GEF interaction site [polypeptide binding]; other site 405955010433 GTP/Mg2+ binding site [chemical binding]; other site 405955010434 Switch I region; other site 405955010435 G2 box; other site 405955010436 G3 box; other site 405955010437 Switch II region; other site 405955010438 G4 box; other site 405955010439 G5 box; other site 405955010440 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 405955010441 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 405955010442 Antibiotic Binding Site [chemical binding]; other site 405955010443 elongation factor G; Reviewed; Region: PRK00007 405955010444 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 405955010445 G1 box; other site 405955010446 putative GEF interaction site [polypeptide binding]; other site 405955010447 GTP/Mg2+ binding site [chemical binding]; other site 405955010448 Switch I region; other site 405955010449 G2 box; other site 405955010450 G3 box; other site 405955010451 Switch II region; other site 405955010452 G4 box; other site 405955010453 G5 box; other site 405955010454 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 405955010455 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 405955010456 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 405955010457 30S ribosomal protein S7; Validated; Region: PRK05302 405955010458 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 405955010459 S17 interaction site [polypeptide binding]; other site 405955010460 S8 interaction site; other site 405955010461 16S rRNA interaction site [nucleotide binding]; other site 405955010462 streptomycin interaction site [chemical binding]; other site 405955010463 23S rRNA interaction site [nucleotide binding]; other site 405955010464 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 405955010465 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 405955010466 sulfur relay protein TusC; Validated; Region: PRK00211 405955010467 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 405955010468 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 405955010469 YheO-like PAS domain; Region: PAS_6; pfam08348 405955010470 HTH domain; Region: HTH_22; pfam13309 405955010471 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 405955010472 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 405955010473 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 405955010474 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 405955010475 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 405955010476 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 405955010477 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 405955010478 TrkA-N domain; Region: TrkA_N; pfam02254 405955010479 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 405955010480 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 405955010481 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955010482 Walker A/P-loop; other site 405955010483 ATP binding site [chemical binding]; other site 405955010484 Q-loop/lid; other site 405955010485 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405955010486 ABC transporter signature motif; other site 405955010487 Walker B; other site 405955010488 D-loop; other site 405955010489 ABC transporter; Region: ABC_tran_2; pfam12848 405955010490 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405955010491 putative hydrolase; Provisional; Region: PRK10985 405955010492 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 405955010493 active site 405955010494 hypothetical protein; Provisional; Region: PRK10738 405955010495 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 405955010496 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 405955010497 ligand binding site [chemical binding]; other site 405955010498 flexible hinge region; other site 405955010499 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 405955010500 putative switch regulator; other site 405955010501 non-specific DNA interactions [nucleotide binding]; other site 405955010502 DNA binding site [nucleotide binding] 405955010503 sequence specific DNA binding site [nucleotide binding]; other site 405955010504 putative cAMP binding site [chemical binding]; other site 405955010505 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 405955010506 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 405955010507 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 405955010508 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 405955010509 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 405955010510 inhibitor-cofactor binding pocket; inhibition site 405955010511 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955010512 catalytic residue [active] 405955010513 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 405955010514 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 405955010515 glutamine binding [chemical binding]; other site 405955010516 catalytic triad [active] 405955010517 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 405955010518 cell filamentation protein Fic; Provisional; Region: PRK10347 405955010519 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 405955010520 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 405955010521 substrate binding site [chemical binding]; other site 405955010522 putative transporter; Provisional; Region: PRK03699 405955010523 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955010524 putative substrate translocation pore; other site 405955010525 nitrite reductase subunit NirD; Provisional; Region: PRK14989 405955010526 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955010527 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405955010528 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 405955010529 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 405955010530 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 405955010531 nitrite transporter NirC; Provisional; Region: PRK11562 405955010532 siroheme synthase; Provisional; Region: cysG; PRK10637 405955010533 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 405955010534 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 405955010535 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 405955010536 active site 405955010537 SAM binding site [chemical binding]; other site 405955010538 homodimer interface [polypeptide binding]; other site 405955010539 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 405955010540 Protein of unknown function; Region: YhfT; pfam10797 405955010541 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 405955010542 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 405955010543 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 405955010544 active site 405955010545 substrate binding pocket [chemical binding]; other site 405955010546 homodimer interaction site [polypeptide binding]; other site 405955010547 putative mutase; Provisional; Region: PRK12383 405955010548 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 405955010549 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 405955010550 dimer interface [polypeptide binding]; other site 405955010551 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 405955010552 active site 405955010553 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405955010554 substrate binding site [chemical binding]; other site 405955010555 catalytic residue [active] 405955010556 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 405955010557 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 405955010558 active site 405955010559 HIGH motif; other site 405955010560 dimer interface [polypeptide binding]; other site 405955010561 KMSKS motif; other site 405955010562 phosphoglycolate phosphatase; Provisional; Region: PRK13222 405955010563 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955010564 motif II; other site 405955010565 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 405955010566 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 405955010567 substrate binding site [chemical binding]; other site 405955010568 hexamer interface [polypeptide binding]; other site 405955010569 metal binding site [ion binding]; metal-binding site 405955010570 DNA adenine methylase; Provisional; Region: PRK10904 405955010571 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 405955010572 cell division protein DamX; Validated; Region: PRK10905 405955010573 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 405955010574 active site 405955010575 dimer interface [polypeptide binding]; other site 405955010576 metal binding site [ion binding]; metal-binding site 405955010577 shikimate kinase; Reviewed; Region: aroK; PRK00131 405955010578 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 405955010579 ADP binding site [chemical binding]; other site 405955010580 magnesium binding site [ion binding]; other site 405955010581 putative shikimate binding site; other site 405955010582 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 405955010583 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 405955010584 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 405955010585 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 405955010586 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 405955010587 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 405955010588 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 405955010589 Transglycosylase; Region: Transgly; pfam00912 405955010590 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 405955010591 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 405955010592 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 405955010593 ADP-ribose binding site [chemical binding]; other site 405955010594 dimer interface [polypeptide binding]; other site 405955010595 active site 405955010596 nudix motif; other site 405955010597 metal binding site [ion binding]; metal-binding site 405955010598 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 405955010599 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 405955010600 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955010601 motif II; other site 405955010602 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405955010603 RNA binding surface [nucleotide binding]; other site 405955010604 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 405955010605 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 405955010606 dimerization interface [polypeptide binding]; other site 405955010607 domain crossover interface; other site 405955010608 redox-dependent activation switch; other site 405955010609 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 405955010610 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 405955010611 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 405955010612 active site 405955010613 substrate-binding site [chemical binding]; other site 405955010614 metal-binding site [ion binding] 405955010615 ATP binding site [chemical binding]; other site 405955010616 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 405955010617 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405955010618 dimerization interface [polypeptide binding]; other site 405955010619 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955010620 dimer interface [polypeptide binding]; other site 405955010621 phosphorylation site [posttranslational modification] 405955010622 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955010623 ATP binding site [chemical binding]; other site 405955010624 G-X-G motif; other site 405955010625 osmolarity response regulator; Provisional; Region: ompR; PRK09468 405955010626 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955010627 active site 405955010628 phosphorylation site [posttranslational modification] 405955010629 intermolecular recognition site; other site 405955010630 dimerization interface [polypeptide binding]; other site 405955010631 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955010632 DNA binding site [nucleotide binding] 405955010633 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 405955010634 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 405955010635 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 405955010636 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 405955010637 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 405955010638 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 405955010639 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 405955010640 RNA binding site [nucleotide binding]; other site 405955010641 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 405955010642 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 405955010643 G1 box; other site 405955010644 GTP/Mg2+ binding site [chemical binding]; other site 405955010645 Switch I region; other site 405955010646 G2 box; other site 405955010647 G3 box; other site 405955010648 Switch II region; other site 405955010649 G4 box; other site 405955010650 G5 box; other site 405955010651 Nucleoside recognition; Region: Gate; pfam07670 405955010652 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 405955010653 Nucleoside recognition; Region: Gate; pfam07670 405955010654 putative transposase; Provisional; Region: PRK09857 405955010655 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 405955010656 carboxylesterase BioH; Provisional; Region: PRK10349 405955010657 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 405955010658 DNA utilization protein GntX; Provisional; Region: PRK11595 405955010659 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405955010660 active site 405955010661 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 405955010662 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 405955010663 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 405955010664 high-affinity gluconate transporter; Provisional; Region: PRK14984 405955010665 gluconate transporter; Region: gntP; TIGR00791 405955010666 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 405955010667 4-alpha-glucanotransferase; Region: malQ; TIGR00217 405955010668 maltodextrin phosphorylase; Provisional; Region: PRK14985 405955010669 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 405955010670 homodimer interface [polypeptide binding]; other site 405955010671 active site pocket [active] 405955010672 transcriptional regulator MalT; Provisional; Region: PRK04841 405955010673 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955010674 DNA binding residues [nucleotide binding] 405955010675 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 405955010676 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 405955010677 putative active site [active] 405955010678 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 405955010679 hypothetical protein; Reviewed; Region: PRK09588 405955010680 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 405955010681 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955010682 ATPases associated with a variety of cellular activities; Region: AAA; smart00382 405955010683 Walker A motif; other site 405955010684 ATP binding site [chemical binding]; other site 405955010685 Walker B motif; other site 405955010686 arginine finger; other site 405955010687 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 405955010688 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 405955010689 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405955010690 intramembrane serine protease GlpG; Provisional; Region: PRK10907 405955010691 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 405955010692 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 405955010693 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 405955010694 active site residue [active] 405955010695 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 405955010696 hypothetical protein; Provisional; Region: PRK09781; cl08057 405955010697 Fimbrial protein; Region: Fimbrial; cl01416 405955010698 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 405955010699 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 405955010700 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 405955010701 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 405955010702 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 405955010703 outer membrane usher protein; Provisional; Region: PRK15193 405955010704 PapC N-terminal domain; Region: PapC_N; pfam13954 405955010705 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 405955010706 PapC C-terminal domain; Region: PapC_C; pfam13953 405955010707 fimbrial chaperone protein StiB; Provisional; Region: PRK15299 405955010708 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 405955010709 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 405955010710 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 405955010711 glycogen phosphorylase; Provisional; Region: PRK14986 405955010712 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 405955010713 homodimer interface [polypeptide binding]; other site 405955010714 active site pocket [active] 405955010715 glycogen synthase; Provisional; Region: glgA; PRK00654 405955010716 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 405955010717 ADP-binding pocket [chemical binding]; other site 405955010718 homodimer interface [polypeptide binding]; other site 405955010719 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 405955010720 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 405955010721 ligand binding site; other site 405955010722 oligomer interface; other site 405955010723 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 405955010724 sulfate 1 binding site; other site 405955010725 glycogen debranching enzyme; Provisional; Region: PRK03705 405955010726 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 405955010727 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 405955010728 active site 405955010729 catalytic site [active] 405955010730 glycogen branching enzyme; Provisional; Region: PRK05402 405955010731 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 405955010732 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 405955010733 active site 405955010734 catalytic site [active] 405955010735 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 405955010736 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 405955010737 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405955010738 putative antibiotic transporter; Provisional; Region: PRK10739 405955010739 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405955010740 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 405955010741 Shikimate kinase; Region: SKI; pfam01202 405955010742 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 405955010743 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955010744 DNA binding site [nucleotide binding] 405955010745 domain linker motif; other site 405955010746 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 405955010747 putative ligand binding site [chemical binding]; other site 405955010748 putative dimerization interface [polypeptide binding]; other site 405955010749 Pirin-related protein [General function prediction only]; Region: COG1741 405955010750 Pirin; Region: Pirin; pfam02678 405955010751 putative oxidoreductase; Provisional; Region: PRK10206 405955010752 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405955010753 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405955010754 putative acetyltransferase YhhY; Provisional; Region: PRK10140 405955010755 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405955010756 Coenzyme A binding pocket [chemical binding]; other site 405955010757 Type VI protein secretion system component Hcp (secreted cytotoxin) [Intracellular trafficking, secretion, and vesicular transport]; Region: Hcp; COG3157 405955010758 YopJ Serine/Threonine acetyltransferase; Region: YopJ; cl07849 405955010759 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 405955010760 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 405955010761 hypothetical protein; Provisional; Region: PRK10350 405955010762 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 405955010763 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 405955010764 putative active site [active] 405955010765 catalytic site [active] 405955010766 putative metal binding site [ion binding]; other site 405955010767 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 405955010768 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 405955010769 Walker A/P-loop; other site 405955010770 ATP binding site [chemical binding]; other site 405955010771 Q-loop/lid; other site 405955010772 ABC transporter signature motif; other site 405955010773 Walker B; other site 405955010774 D-loop; other site 405955010775 H-loop/switch region; other site 405955010776 TOBE domain; Region: TOBE_2; pfam08402 405955010777 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 405955010778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955010779 dimer interface [polypeptide binding]; other site 405955010780 conserved gate region; other site 405955010781 putative PBP binding loops; other site 405955010782 ABC-ATPase subunit interface; other site 405955010783 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 405955010784 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955010785 dimer interface [polypeptide binding]; other site 405955010786 conserved gate region; other site 405955010787 putative PBP binding loops; other site 405955010788 ABC-ATPase subunit interface; other site 405955010789 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 405955010790 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 405955010791 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 405955010792 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 405955010793 Walker A/P-loop; other site 405955010794 ATP binding site [chemical binding]; other site 405955010795 Q-loop/lid; other site 405955010796 ABC transporter signature motif; other site 405955010797 Walker B; other site 405955010798 D-loop; other site 405955010799 H-loop/switch region; other site 405955010800 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 405955010801 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 405955010802 Walker A/P-loop; other site 405955010803 ATP binding site [chemical binding]; other site 405955010804 Q-loop/lid; other site 405955010805 ABC transporter signature motif; other site 405955010806 Walker B; other site 405955010807 D-loop; other site 405955010808 H-loop/switch region; other site 405955010809 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 405955010810 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 405955010811 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 405955010812 TM-ABC transporter signature motif; other site 405955010813 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405955010814 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 405955010815 TM-ABC transporter signature motif; other site 405955010816 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 405955010817 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 405955010818 dimerization interface [polypeptide binding]; other site 405955010819 ligand binding site [chemical binding]; other site 405955010820 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 405955010821 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 405955010822 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 405955010823 dimerization interface [polypeptide binding]; other site 405955010824 ligand binding site [chemical binding]; other site 405955010825 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 405955010826 active pocket/dimerization site; other site 405955010827 active site 405955010828 PTS system sorbose subfamily IIB component; Region: PTSIIB_sorb; pfam03830 405955010829 active site 405955010830 phosphorylation site [posttranslational modification] 405955010831 PTS system sorbose-specific iic component; Region: EII-Sor; pfam03609 405955010832 PTS system mannose/fructose/sorbose family IID component; Region: EIID-AGA; pfam03613 405955010833 Formate/glycerate dehydrogenases, D-specific 2-hydroxy acid dehydrogenases and related dehydrogenases; Region: FDH_GDH_like; cl17240 405955010834 Phosphoglycerate dehydrogenase and related dehydrogenases [Amino acid transport and metabolism]; Region: SerA; COG0111 405955010835 NAD binding site [chemical binding]; other site 405955010836 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 405955010837 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 405955010838 inhibitor site; inhibition site 405955010839 active site 405955010840 dimer interface [polypeptide binding]; other site 405955010841 catalytic residue [active] 405955010842 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 405955010843 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 405955010844 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405955010845 DNA binding residues [nucleotide binding] 405955010846 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 405955010847 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 405955010848 cell division protein FtsE; Provisional; Region: PRK10908 405955010849 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955010850 Walker A/P-loop; other site 405955010851 ATP binding site [chemical binding]; other site 405955010852 Q-loop/lid; other site 405955010853 ABC transporter signature motif; other site 405955010854 Walker B; other site 405955010855 D-loop; other site 405955010856 H-loop/switch region; other site 405955010857 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 405955010858 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 405955010859 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 405955010860 P loop; other site 405955010861 GTP binding site [chemical binding]; other site 405955010862 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 405955010863 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955010864 S-adenosylmethionine binding site [chemical binding]; other site 405955010865 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 405955010866 Predicted membrane protein [Function unknown]; Region: COG3714 405955010867 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 405955010868 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 405955010869 metal-binding site [ion binding] 405955010870 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405955010871 hypothetical protein; Provisional; Region: PRK11212 405955010872 hypothetical protein; Provisional; Region: PRK11615 405955010873 major facilitator superfamily transporter; Provisional; Region: PRK05122 405955010874 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955010875 putative substrate translocation pore; other site 405955010876 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 405955010877 Domain of unknown function DUF20; Region: UPF0118; pfam01594 405955010878 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 405955010879 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 405955010880 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 405955010881 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 405955010882 substrate binding site [chemical binding]; other site 405955010883 nickel transporter permease NikB; Provisional; Region: PRK10352 405955010884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955010885 dimer interface [polypeptide binding]; other site 405955010886 conserved gate region; other site 405955010887 putative PBP binding loops; other site 405955010888 ABC-ATPase subunit interface; other site 405955010889 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 405955010890 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955010891 dimer interface [polypeptide binding]; other site 405955010892 conserved gate region; other site 405955010893 putative PBP binding loops; other site 405955010894 ABC-ATPase subunit interface; other site 405955010895 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 405955010896 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955010897 Walker A/P-loop; other site 405955010898 ATP binding site [chemical binding]; other site 405955010899 Q-loop/lid; other site 405955010900 ABC transporter signature motif; other site 405955010901 Walker B; other site 405955010902 D-loop; other site 405955010903 H-loop/switch region; other site 405955010904 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405955010905 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 405955010906 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955010907 Walker A/P-loop; other site 405955010908 ATP binding site [chemical binding]; other site 405955010909 Q-loop/lid; other site 405955010910 ABC transporter signature motif; other site 405955010911 Walker B; other site 405955010912 D-loop; other site 405955010913 H-loop/switch region; other site 405955010914 nickel responsive regulator; Provisional; Region: PRK02967 405955010915 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 405955010916 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 405955010917 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955010918 DNA-binding site [nucleotide binding]; DNA binding site 405955010919 UTRA domain; Region: UTRA; pfam07702 405955010920 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405955010921 active site 405955010922 phosphorylation site [posttranslational modification] 405955010923 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 405955010924 active site 405955010925 P-loop; other site 405955010926 phosphorylation site [posttranslational modification] 405955010927 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 405955010928 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 405955010929 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 405955010930 uncharacterized subgroup; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_1; cd07774 405955010931 putative N- and C-terminal domain interface [polypeptide binding]; other site 405955010932 putative active site [active] 405955010933 putative MgATP binding site [chemical binding]; other site 405955010934 catalytic site [active] 405955010935 metal binding site [ion binding]; metal-binding site 405955010936 putative carbohydrate binding site [chemical binding]; other site 405955010937 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405955010938 dimerization domain swap beta strand [polypeptide binding]; other site 405955010939 regulatory protein interface [polypeptide binding]; other site 405955010940 active site 405955010941 regulatory phosphorylation site [posttranslational modification]; other site 405955010942 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 405955010943 intersubunit interface [polypeptide binding]; other site 405955010944 active site 405955010945 zinc binding site [ion binding]; other site 405955010946 Na+ binding site [ion binding]; other site 405955010947 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 405955010948 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 405955010949 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405955010950 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 405955010951 Walker A/P-loop; other site 405955010952 ATP binding site [chemical binding]; other site 405955010953 Q-loop/lid; other site 405955010954 ABC transporter signature motif; other site 405955010955 Walker B; other site 405955010956 D-loop; other site 405955010957 H-loop/switch region; other site 405955010958 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 405955010959 Walker A/P-loop; other site 405955010960 ATP binding site [chemical binding]; other site 405955010961 Q-loop/lid; other site 405955010962 ABC transporter signature motif; other site 405955010963 Walker B; other site 405955010964 D-loop; other site 405955010965 H-loop/switch region; other site 405955010966 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 405955010967 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 405955010968 HlyD family secretion protein; Region: HlyD; pfam00529 405955010969 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955010970 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955010971 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 405955010972 Predicted flavoproteins [General function prediction only]; Region: COG2081 405955010973 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405955010974 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 405955010975 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 405955010976 universal stress protein UspB; Provisional; Region: PRK04960 405955010977 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405955010978 Ligand Binding Site [chemical binding]; other site 405955010979 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 405955010980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955010981 POT family; Region: PTR2; pfam00854 405955010982 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955010983 S-adenosylmethionine binding site [chemical binding]; other site 405955010984 oligopeptidase A; Provisional; Region: PRK10911 405955010985 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 405955010986 active site 405955010987 Zn binding site [ion binding]; other site 405955010988 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 405955010989 glutathione reductase; Validated; Region: PRK06116 405955010990 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405955010991 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955010992 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405955010993 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 405955010994 ArsC family; Region: ArsC; pfam03960 405955010995 catalytic residues [active] 405955010996 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 405955010997 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405955010998 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955010999 DNA binding residues [nucleotide binding] 405955011000 dimerization interface [polypeptide binding]; other site 405955011001 Putative heme degradation protein [Inorganic ion transport and metabolism]; Region: HemS; COG3720 405955011002 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 405955011003 Haemin-degrading HemS.ChuX domain; Region: HemS; pfam05171 405955011004 TonB-dependent heme/hemoglobin receptor family protein; Region: TonB-hemin; TIGR01785 405955011005 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 405955011006 N-terminal plug; other site 405955011007 ligand-binding site [chemical binding]; other site 405955011008 ABC-type hemin transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: ChuT; COG4558 405955011009 Hemin binding protein HutB. These proteins have been shown to function as initial receptors in ABC transport of hemin and hemoproteins in many eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that share a...; Region: HutB; cd01149 405955011010 putative hemin binding site; other site 405955011011 coproporphyrinogen III oxidase; Provisional; Region: PRK09058 405955011012 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955011013 FeS/SAM binding site; other site 405955011014 Putative heme iron utilization protein [Inorganic ion transport and metabolism]; Region: HugX; COG3721 405955011015 atypical (a) SDRs, subgroup 5; Region: SDR_a5; cd05243 405955011016 NADH(P)-binding; Region: NAD_binding_10; pfam13460 405955011017 NAD(P) binding site [chemical binding]; other site 405955011018 putative active site [active] 405955011019 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405955011020 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955011021 ABC-ATPase subunit interface; other site 405955011022 dimer interface [polypeptide binding]; other site 405955011023 putative PBP binding regions; other site 405955011024 ABC-type hemin transport system, ATPase component [Inorganic ion transport and metabolism]; Region: COG4559 405955011025 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405955011026 Walker A/P-loop; other site 405955011027 ATP binding site [chemical binding]; other site 405955011028 Q-loop/lid; other site 405955011029 ABC transporter signature motif; other site 405955011030 Walker B; other site 405955011031 D-loop; other site 405955011032 H-loop/switch region; other site 405955011033 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 405955011034 MgtC family; Region: MgtC; pfam02308 405955011035 acid-resistance protein; Provisional; Region: hdeB; PRK11566 405955011036 acid-resistance protein; Provisional; Region: PRK10208 405955011037 acid-resistance membrane protein; Provisional; Region: PRK10209 405955011038 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 405955011039 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 405955011040 pyruvate kinase; Provisional; Region: PRK05826 405955011041 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 405955011042 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955011043 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955011044 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 405955011045 Protein export membrane protein; Region: SecD_SecF; cl14618 405955011046 transcriptional regulator YdeO; Provisional; Region: PRK09940 405955011047 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955011048 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 405955011049 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955011050 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 405955011051 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955011052 catalytic residue [active] 405955011053 Haem-binding domain; Region: Haem_bd; pfam14376 405955011054 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 405955011055 trehalase; Provisional; Region: treF; PRK13270 405955011056 Trehalase; Region: Trehalase; pfam01204 405955011057 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405955011058 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955011059 DNA binding residues [nucleotide binding] 405955011060 dimerization interface [polypeptide binding]; other site 405955011061 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405955011062 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955011063 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 405955011064 putative effector binding pocket; other site 405955011065 putative dimerization interface [polypeptide binding]; other site 405955011066 inner membrane protein YhjD; Region: TIGR00766 405955011067 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955011068 metabolite-proton symporter; Region: 2A0106; TIGR00883 405955011069 putative substrate translocation pore; other site 405955011070 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 405955011071 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 405955011072 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955011073 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405955011074 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 405955011075 substrate binding site [chemical binding]; other site 405955011076 ATP binding site [chemical binding]; other site 405955011077 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 405955011078 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 405955011079 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 405955011080 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405955011081 putative diguanylate cyclase; Provisional; Region: PRK13561 405955011082 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 405955011083 metal binding site [ion binding]; metal-binding site 405955011084 active site 405955011085 I-site; other site 405955011086 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955011087 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 405955011088 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405955011089 binding surface 405955011090 TPR motif; other site 405955011091 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405955011092 binding surface 405955011093 TPR motif; other site 405955011094 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 405955011095 TPR motif; other site 405955011096 binding surface 405955011097 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 405955011098 endo-1,4-D-glucanase; Provisional; Region: PRK11097 405955011099 cellulose synthase regulator protein; Provisional; Region: PRK11114 405955011100 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 405955011101 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 405955011102 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 405955011103 DXD motif; other site 405955011104 PilZ domain; Region: PilZ; pfam07238 405955011105 cell division protein; Provisional; Region: PRK10037 405955011106 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 405955011107 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 405955011108 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 405955011109 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 405955011110 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 405955011111 serine transporter; Region: stp; TIGR00814 405955011112 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 405955011113 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955011114 Walker A/P-loop; other site 405955011115 ATP binding site [chemical binding]; other site 405955011116 Q-loop/lid; other site 405955011117 ABC transporter signature motif; other site 405955011118 Walker B; other site 405955011119 D-loop; other site 405955011120 H-loop/switch region; other site 405955011121 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405955011122 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 405955011123 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955011124 Walker A/P-loop; other site 405955011125 ATP binding site [chemical binding]; other site 405955011126 Q-loop/lid; other site 405955011127 ABC transporter signature motif; other site 405955011128 Walker B; other site 405955011129 D-loop; other site 405955011130 H-loop/switch region; other site 405955011131 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 405955011132 dipeptide transporter; Provisional; Region: PRK10913 405955011133 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405955011134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955011135 dimer interface [polypeptide binding]; other site 405955011136 conserved gate region; other site 405955011137 putative PBP binding loops; other site 405955011138 ABC-ATPase subunit interface; other site 405955011139 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405955011140 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955011141 dimer interface [polypeptide binding]; other site 405955011142 conserved gate region; other site 405955011143 putative PBP binding loops; other site 405955011144 ABC-ATPase subunit interface; other site 405955011145 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 405955011146 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 405955011147 peptide binding site [polypeptide binding]; other site 405955011148 phosphoethanolamine transferase; Provisional; Region: PRK11560 405955011149 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 405955011150 Sulfatase; Region: Sulfatase; pfam00884 405955011151 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 405955011152 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955011153 putative substrate translocation pore; other site 405955011154 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 405955011155 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 405955011156 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405955011157 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405955011158 Coenzyme A binding pocket [chemical binding]; other site 405955011159 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 405955011160 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 405955011161 molybdopterin cofactor binding site [chemical binding]; other site 405955011162 substrate binding site [chemical binding]; other site 405955011163 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 405955011164 molybdopterin cofactor binding site; other site 405955011165 putative outer membrane lipoprotein; Provisional; Region: PRK10510 405955011166 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 405955011167 ligand binding site [chemical binding]; other site 405955011168 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 405955011169 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 405955011170 dimerization interface [polypeptide binding]; other site 405955011171 ligand binding site [chemical binding]; other site 405955011172 NADP binding site [chemical binding]; other site 405955011173 catalytic site [active] 405955011174 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 405955011175 Predicted transcriptional regulator [Transcription]; Region: COG2944 405955011176 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955011177 non-specific DNA binding site [nucleotide binding]; other site 405955011178 salt bridge; other site 405955011179 sequence-specific DNA binding site [nucleotide binding]; other site 405955011180 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 405955011181 DALR anticodon binding domain; Region: DALR_1; pfam05746 405955011182 anticodon binding site; other site 405955011183 tRNA binding surface [nucleotide binding]; other site 405955011184 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 405955011185 dimer interface [polypeptide binding]; other site 405955011186 motif 1; other site 405955011187 active site 405955011188 motif 2; other site 405955011189 motif 3; other site 405955011190 YsaB-like lipoprotein; Region: YsaB; pfam13983 405955011191 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 405955011192 Acyltransferase family; Region: Acyl_transf_3; pfam01757 405955011193 hypothetical protein; Provisional; Region: PRK11383 405955011194 yiaA/B two helix domain; Region: YiaAB; pfam05360 405955011195 yiaA/B two helix domain; Region: YiaAB; pfam05360 405955011196 hypothetical protein; Provisional; Region: PRK11403 405955011197 yiaA/B two helix domain; Region: YiaAB; pfam05360 405955011198 xylulokinase; Provisional; Region: PRK15027 405955011199 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 405955011200 N- and C-terminal domain interface [polypeptide binding]; other site 405955011201 active site 405955011202 MgATP binding site [chemical binding]; other site 405955011203 catalytic site [active] 405955011204 metal binding site [ion binding]; metal-binding site 405955011205 xylulose binding site [chemical binding]; other site 405955011206 homodimer interface [polypeptide binding]; other site 405955011207 xylose isomerase; Provisional; Region: PRK05474 405955011208 xylose isomerase; Region: xylose_isom_A; TIGR02630 405955011209 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 405955011210 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 405955011211 putative ligand binding site [chemical binding]; other site 405955011212 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 405955011213 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405955011214 Walker A/P-loop; other site 405955011215 ATP binding site [chemical binding]; other site 405955011216 Q-loop/lid; other site 405955011217 ABC transporter signature motif; other site 405955011218 Walker B; other site 405955011219 D-loop; other site 405955011220 H-loop/switch region; other site 405955011221 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405955011222 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405955011223 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405955011224 TM-ABC transporter signature motif; other site 405955011225 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 405955011226 putative dimerization interface [polypeptide binding]; other site 405955011227 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405955011228 putative ligand binding site [chemical binding]; other site 405955011229 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955011230 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405955011231 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955011232 hypothetical protein; Provisional; Region: PRK10356 405955011233 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 405955011234 alpha-amylase; Reviewed; Region: malS; PRK09505 405955011235 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 405955011236 active site 405955011237 catalytic site [active] 405955011238 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 405955011239 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405955011240 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955011241 homodimer interface [polypeptide binding]; other site 405955011242 catalytic residue [active] 405955011243 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 405955011244 Transcriptional regulator [Transcription]; Region: IclR; COG1414 405955011245 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 405955011246 Bacterial transcriptional regulator; Region: IclR; pfam01614 405955011247 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 405955011248 Domain of unknown function (DUF386); Region: DUF386; pfam04074 405955011249 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 405955011250 DctM-like transporters; Region: DctM; pfam06808 405955011251 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 405955011252 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 405955011253 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 405955011254 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 405955011255 putative N- and C-terminal domain interface [polypeptide binding]; other site 405955011256 putative active site [active] 405955011257 MgATP binding site [chemical binding]; other site 405955011258 catalytic site [active] 405955011259 metal binding site [ion binding]; metal-binding site 405955011260 putative xylulose binding site [chemical binding]; other site 405955011261 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 405955011262 active site 405955011263 dimer interface [polypeptide binding]; other site 405955011264 magnesium binding site [ion binding]; other site 405955011265 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 405955011266 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 405955011267 AP (apurinic/apyrimidinic) site pocket; other site 405955011268 DNA interaction; other site 405955011269 Metal-binding active site; metal-binding site 405955011270 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 405955011271 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 405955011272 NAD(P) binding site [chemical binding]; other site 405955011273 catalytic residues [active] 405955011274 Fic family protein [Function unknown]; Region: COG3177 405955011275 Fic/DOC family; Region: Fic; pfam02661 405955011276 putative alcohol dehydrogenase; Provisional; Region: PRK09860 405955011277 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 405955011278 dimer interface [polypeptide binding]; other site 405955011279 active site 405955011280 metal binding site [ion binding]; metal-binding site 405955011281 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 405955011282 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 405955011283 G1 box; other site 405955011284 putative GEF interaction site [polypeptide binding]; other site 405955011285 GTP/Mg2+ binding site [chemical binding]; other site 405955011286 Switch I region; other site 405955011287 G2 box; other site 405955011288 G3 box; other site 405955011289 Switch II region; other site 405955011290 G4 box; other site 405955011291 G5 box; other site 405955011292 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 405955011293 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 405955011294 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 405955011295 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 405955011296 selenocysteine synthase; Provisional; Region: PRK04311 405955011297 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 405955011298 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 405955011299 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405955011300 catalytic residue [active] 405955011301 putative glutathione S-transferase; Provisional; Region: PRK10357 405955011302 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 405955011303 putative C-terminal domain interface [polypeptide binding]; other site 405955011304 putative GSH binding site (G-site) [chemical binding]; other site 405955011305 putative dimer interface [polypeptide binding]; other site 405955011306 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 405955011307 dimer interface [polypeptide binding]; other site 405955011308 N-terminal domain interface [polypeptide binding]; other site 405955011309 putative substrate binding pocket (H-site) [chemical binding]; other site 405955011310 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 405955011311 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955011312 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955011313 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 405955011314 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 405955011315 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 405955011316 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 405955011317 active site 405955011318 P-loop; other site 405955011319 phosphorylation site [posttranslational modification] 405955011320 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405955011321 active site 405955011322 phosphorylation site [posttranslational modification] 405955011323 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 405955011324 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 405955011325 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 405955011326 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 405955011327 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 405955011328 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 405955011329 hypothetical protein; Provisional; Region: PRK11020 405955011330 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 405955011331 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 405955011332 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 405955011333 trimer interface [polypeptide binding]; other site 405955011334 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 405955011335 trimer interface [polypeptide binding]; other site 405955011336 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 405955011337 Left-handed beta-roll, including virulence factors and various other proteins; Region: LbR-like; cl17507 405955011338 Haemagglutinin; Region: HIM; pfam05662 405955011339 Haemagglutinin; Region: HIM; pfam05662 405955011340 YadA-like C-terminal region; Region: YadA; pfam03895 405955011341 L-lactate permease; Provisional; Region: PRK10420 405955011342 glycolate transporter; Provisional; Region: PRK09695 405955011343 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 405955011344 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955011345 DNA-binding site [nucleotide binding]; DNA binding site 405955011346 FCD domain; Region: FCD; pfam07729 405955011347 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 405955011348 Family of homologous FMN-dependent alpha-hydroxyacid oxidizing enzymes. This family occurs in both prokaryotes and eukaryotes. Members of this family include flavocytochrome b2 (FCB2), glycolate oxidase (GOX), lactate monooxygenase (LMO), mandelate...; Region: alpha_hydroxyacid_oxid_FMN; cd02809 405955011349 active site 405955011350 substrate binding site [chemical binding]; other site 405955011351 FMN binding site [chemical binding]; other site 405955011352 putative catalytic residues [active] 405955011353 putative rRNA methylase; Provisional; Region: PRK10358 405955011354 serine acetyltransferase; Provisional; Region: cysE; PRK11132 405955011355 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 405955011356 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 405955011357 trimer interface [polypeptide binding]; other site 405955011358 active site 405955011359 substrate binding site [chemical binding]; other site 405955011360 CoA binding site [chemical binding]; other site 405955011361 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 405955011362 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 405955011363 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 405955011364 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 405955011365 SecA binding site; other site 405955011366 Preprotein binding site; other site 405955011367 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 405955011368 active site residue [active] 405955011369 phosphoglyceromutase; Provisional; Region: PRK05434 405955011370 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 405955011371 AmiB activator; Provisional; Region: PRK11637 405955011372 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 405955011373 Peptidase family M23; Region: Peptidase_M23; pfam01551 405955011374 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 405955011375 putative active site [active] 405955011376 NodB motif; other site 405955011377 putative glycosyl transferase; Provisional; Region: PRK10073 405955011378 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405955011379 active site 405955011380 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 405955011381 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 405955011382 NAD(P) binding site [chemical binding]; other site 405955011383 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 405955011384 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 405955011385 substrate-cofactor binding pocket; other site 405955011386 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955011387 catalytic residue [active] 405955011388 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 405955011389 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 405955011390 NADP binding site [chemical binding]; other site 405955011391 homopentamer interface [polypeptide binding]; other site 405955011392 substrate binding site [chemical binding]; other site 405955011393 active site 405955011394 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 405955011395 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 405955011396 putative active site [active] 405955011397 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 405955011398 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 405955011399 putative active site [active] 405955011400 Lipid A core - O-antigen ligase and related enzymes [Cell envelope biogenesis, outer membrane]; Region: RfaL; COG3307 405955011401 O-Antigen ligase; Region: Wzy_C; pfam04932 405955011402 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 405955011403 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 405955011404 active site 405955011405 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 405955011406 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 405955011407 Ligand binding site; other site 405955011408 metal-binding site 405955011409 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 405955011410 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 405955011411 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 405955011412 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 405955011413 Ligand binding site; other site 405955011414 metal-binding site 405955011415 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 405955011416 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 405955011417 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 405955011418 Ligand binding site; other site 405955011419 metal-binding site 405955011420 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 405955011421 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 405955011422 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 405955011423 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 405955011424 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 405955011425 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 405955011426 putative active site [active] 405955011427 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 405955011428 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 405955011429 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 405955011430 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 405955011431 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 405955011432 DNA binding site [nucleotide binding] 405955011433 catalytic residue [active] 405955011434 H2TH interface [polypeptide binding]; other site 405955011435 putative catalytic residues [active] 405955011436 turnover-facilitating residue; other site 405955011437 intercalation triad [nucleotide binding]; other site 405955011438 8OG recognition residue [nucleotide binding]; other site 405955011439 putative reading head residues; other site 405955011440 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 405955011441 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 405955011442 hypothetical protein; Reviewed; Region: PRK00024 405955011443 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 405955011444 MPN+ (JAMM) motif; other site 405955011445 Zinc-binding site [ion binding]; other site 405955011446 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 405955011447 Flavoprotein; Region: Flavoprotein; pfam02441 405955011448 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 405955011449 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 405955011450 trimer interface [polypeptide binding]; other site 405955011451 active site 405955011452 division inhibitor protein; Provisional; Region: slmA; PRK09480 405955011453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955011454 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405955011455 active site 405955011456 ribonuclease PH; Reviewed; Region: rph; PRK00173 405955011457 Ribonuclease PH; Region: RNase_PH_bact; cd11362 405955011458 hexamer interface [polypeptide binding]; other site 405955011459 active site 405955011460 hypothetical protein; Provisional; Region: PRK11820 405955011461 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 405955011462 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 405955011463 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 405955011464 BRO family, N-terminal domain; Region: Bro-N; pfam02498 405955011465 Predicted membrane protein [Function unknown]; Region: COG2860 405955011466 UPF0126 domain; Region: UPF0126; pfam03458 405955011467 UPF0126 domain; Region: UPF0126; pfam03458 405955011468 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 405955011469 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 405955011470 nucleotide binding pocket [chemical binding]; other site 405955011471 K-X-D-G motif; other site 405955011472 catalytic site [active] 405955011473 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 405955011474 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 405955011475 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 405955011476 catalytic site [active] 405955011477 G-X2-G-X-G-K; other site 405955011478 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 405955011479 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 405955011480 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 405955011481 Zn2+ binding site [ion binding]; other site 405955011482 Mg2+ binding site [ion binding]; other site 405955011483 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 405955011484 synthetase active site [active] 405955011485 NTP binding site [chemical binding]; other site 405955011486 metal binding site [ion binding]; metal-binding site 405955011487 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 405955011488 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 405955011489 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 405955011490 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 405955011491 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 405955011492 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 405955011493 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 405955011494 generic binding surface II; other site 405955011495 ssDNA binding site; other site 405955011496 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405955011497 ATP binding site [chemical binding]; other site 405955011498 putative Mg++ binding site [ion binding]; other site 405955011499 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405955011500 nucleotide binding region [chemical binding]; other site 405955011501 ATP-binding site [chemical binding]; other site 405955011502 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 405955011503 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 405955011504 AsmA family; Region: AsmA; pfam05170 405955011505 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 405955011506 Protein of unknown function (DUF1498); Region: DUF1498; pfam07385 405955011507 fructokinase; Reviewed; Region: PRK09557 405955011508 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405955011509 nucleotide binding site [chemical binding]; other site 405955011510 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 405955011511 intersubunit interface [polypeptide binding]; other site 405955011512 active site 405955011513 zinc binding site [ion binding]; other site 405955011514 Na+ binding site [ion binding]; other site 405955011515 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 405955011516 intersubunit interface [polypeptide binding]; other site 405955011517 active site 405955011518 zinc binding site [ion binding]; other site 405955011519 Na+ binding site [ion binding]; other site 405955011520 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 405955011521 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 405955011522 active site 405955011523 P-loop; other site 405955011524 phosphorylation site [posttranslational modification] 405955011525 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405955011526 active site 405955011527 phosphorylation site [posttranslational modification] 405955011528 Transcriptional antiterminator [Transcription]; Region: BglG; COG3711 405955011529 HTH domain; Region: HTH_11; pfam08279 405955011530 Mga helix-turn-helix domain; Region: Mga; pfam05043 405955011531 PRD domain; Region: PRD; pfam00874 405955011532 PRD domain; Region: PRD; pfam00874 405955011533 PTS_IIB_bgl_like: the PTS (phosphotransferase system) IIB domain of a family of sensory systems composed of a membrane-bound sugar-sensor (similar to BglF) and a transcription antiterminator (similar to BglG) which regulate expression of genes involved...; Region: PTS_IIB_bgl_like; cd05568 405955011534 active site 405955011535 P-loop; other site 405955011536 phosphorylation site [posttranslational modification] 405955011537 putative alpha-glucosidase; Provisional; Region: PRK10658 405955011538 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 405955011539 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 405955011540 active site 405955011541 homotrimer interface [polypeptide binding]; other site 405955011542 catalytic site [active] 405955011543 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 405955011544 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 405955011545 putative transporter; Provisional; Region: PRK11462 405955011546 Virulence protein [General function prediction only]; Region: COG3943 405955011547 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 405955011548 EamA-like transporter family; Region: EamA; pfam00892 405955011549 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405955011550 EamA-like transporter family; Region: EamA; pfam00892 405955011551 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 405955011552 lipoprotein, YaeC family; Region: TIGR00363 405955011553 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 405955011554 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955011555 putative substrate translocation pore; other site 405955011556 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 405955011557 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405955011558 cryptic adenine deaminase; Provisional; Region: PRK10027 405955011559 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405955011560 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 405955011561 active site 405955011562 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 405955011563 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 405955011564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955011565 putative substrate translocation pore; other site 405955011566 regulatory protein UhpC; Provisional; Region: PRK11663 405955011567 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955011568 putative substrate translocation pore; other site 405955011569 sensory histidine kinase UhpB; Provisional; Region: PRK11644 405955011570 MASE1; Region: MASE1; pfam05231 405955011571 Histidine kinase; Region: HisKA_3; pfam07730 405955011572 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955011573 ATP binding site [chemical binding]; other site 405955011574 Mg2+ binding site [ion binding]; other site 405955011575 G-X-G motif; other site 405955011576 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 405955011577 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955011578 active site 405955011579 phosphorylation site [posttranslational modification] 405955011580 intermolecular recognition site; other site 405955011581 dimerization interface [polypeptide binding]; other site 405955011582 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955011583 DNA binding residues [nucleotide binding] 405955011584 dimerization interface [polypeptide binding]; other site 405955011585 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 405955011586 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 405955011587 putative valine binding site [chemical binding]; other site 405955011588 dimer interface [polypeptide binding]; other site 405955011589 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 405955011590 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405955011591 PYR/PP interface [polypeptide binding]; other site 405955011592 dimer interface [polypeptide binding]; other site 405955011593 TPP binding site [chemical binding]; other site 405955011594 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405955011595 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 405955011596 TPP-binding site [chemical binding]; other site 405955011597 dimer interface [polypeptide binding]; other site 405955011598 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 405955011599 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955011600 putative substrate translocation pore; other site 405955011601 Arylsulfatase regulator (Fe-S oxidoreductase) [General function prediction only]; Region: AslB; COG0641 405955011602 Domain of unknown function (DUF202); Region: DUF202; pfam02656 405955011603 Predicted membrane protein [Function unknown]; Region: COG2149 405955011604 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 405955011605 Sulfatase; Region: Sulfatase; pfam00884 405955011606 putative transporter; Provisional; Region: PRK10484 405955011607 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 405955011608 Na binding site [ion binding]; other site 405955011609 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 405955011610 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955011611 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405955011612 putative transporter; Validated; Region: PRK03818 405955011613 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 405955011614 TrkA-C domain; Region: TrkA_C; pfam02080 405955011615 TrkA-C domain; Region: TrkA_C; pfam02080 405955011616 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 405955011617 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405955011618 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 405955011619 putative dimer interface [polypeptide binding]; other site 405955011620 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 405955011621 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 405955011622 putative dimer interface [polypeptide binding]; other site 405955011623 hypothetical protein; Provisional; Region: PRK11616 405955011624 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 405955011625 putative oxidoreductase; Provisional; Region: PRK11445 405955011626 hypothetical protein; Provisional; Region: PRK07236 405955011627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955011628 D-galactonate transporter; Region: 2A0114; TIGR00893 405955011629 putative substrate translocation pore; other site 405955011630 galactonate dehydratase; Provisional; Region: PRK14017 405955011631 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 405955011632 putative active site pocket [active] 405955011633 putative metal binding site [ion binding]; other site 405955011634 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 405955011635 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 405955011636 active site 405955011637 intersubunit interface [polypeptide binding]; other site 405955011638 catalytic residue [active] 405955011639 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 405955011640 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 405955011641 Transcriptional regulators [Transcription]; Region: FadR; COG2186 405955011642 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955011643 DNA-binding site [nucleotide binding]; DNA binding site 405955011644 FCD domain; Region: FCD; pfam07729 405955011645 hypothetical protein; Provisional; Region: PRK10215 405955011646 sugar phosphate phosphatase; Provisional; Region: PRK10513 405955011647 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955011648 active site 405955011649 motif I; other site 405955011650 motif II; other site 405955011651 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955011652 hypothetical protein; Provisional; Region: PRK11426 405955011653 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 405955011654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955011655 Mg2+ binding site [ion binding]; other site 405955011656 G-X-G motif; other site 405955011657 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 405955011658 anchoring element; other site 405955011659 dimer interface [polypeptide binding]; other site 405955011660 ATP binding site [chemical binding]; other site 405955011661 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 405955011662 active site 405955011663 putative metal-binding site [ion binding]; other site 405955011664 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 405955011665 recF protein; Region: recf; TIGR00611 405955011666 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955011667 Walker A/P-loop; other site 405955011668 ATP binding site [chemical binding]; other site 405955011669 Q-loop/lid; other site 405955011670 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955011671 ABC transporter signature motif; other site 405955011672 Walker B; other site 405955011673 D-loop; other site 405955011674 H-loop/switch region; other site 405955011675 DNA polymerase III subunit beta; Validated; Region: PRK05643 405955011676 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 405955011677 putative DNA binding surface [nucleotide binding]; other site 405955011678 dimer interface [polypeptide binding]; other site 405955011679 beta-clamp/clamp loader binding surface; other site 405955011680 beta-clamp/translesion DNA polymerase binding surface; other site 405955011681 DnaA N-terminal domain; Region: DnaA_N; pfam11638 405955011682 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 405955011683 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955011684 Walker A motif; other site 405955011685 ATP binding site [chemical binding]; other site 405955011686 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 405955011687 Walker B motif; other site 405955011688 arginine finger; other site 405955011689 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 405955011690 DnaA box-binding interface [nucleotide binding]; other site 405955011691 ribonuclease P; Reviewed; Region: rnpA; PRK01732 405955011692 membrane protein insertase; Provisional; Region: PRK01318 405955011693 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 405955011694 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 405955011695 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 405955011696 trmE is a tRNA modification GTPase; Region: trmE; cd04164 405955011697 G1 box; other site 405955011698 GTP/Mg2+ binding site [chemical binding]; other site 405955011699 Switch I region; other site 405955011700 G2 box; other site 405955011701 Switch II region; other site 405955011702 G3 box; other site 405955011703 G4 box; other site 405955011704 G5 box; other site 405955011705 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 405955011706 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 405955011707 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 405955011708 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 405955011709 catalytic residue [active] 405955011710 tryptophan permease TnaB; Provisional; Region: PRK09664 405955011711 aromatic amino acid transport protein; Region: araaP; TIGR00837 405955011712 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 405955011713 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955011714 putative substrate translocation pore; other site 405955011715 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 405955011716 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955011717 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 405955011718 substrate binding pocket [chemical binding]; other site 405955011719 dimerization interface [polypeptide binding]; other site 405955011720 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 405955011721 Predicted flavoprotein [General function prediction only]; Region: COG0431 405955011722 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 405955011723 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405955011724 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 405955011725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955011726 active site 405955011727 motif I; other site 405955011728 motif II; other site 405955011729 putative inner membrane protein; Provisional; Region: PRK09823 405955011730 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 405955011731 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 405955011732 active site 405955011733 trimer interface [polypeptide binding]; other site 405955011734 allosteric site; other site 405955011735 active site lid [active] 405955011736 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 405955011737 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 405955011738 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405955011739 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 405955011740 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 405955011741 trimer interface; other site 405955011742 sugar binding site [chemical binding]; other site 405955011743 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 405955011744 beta-galactosidase; Region: BGL; TIGR03356 405955011745 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 405955011746 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405955011747 active site turn [active] 405955011748 phosphorylation site [posttranslational modification] 405955011749 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405955011750 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 405955011751 HPr interaction site; other site 405955011752 glycerol kinase (GK) interaction site [polypeptide binding]; other site 405955011753 active site 405955011754 phosphorylation site [posttranslational modification] 405955011755 transcriptional antiterminator BglG; Provisional; Region: PRK09772 405955011756 CAT RNA binding domain; Region: CAT_RBD; pfam03123 405955011757 PRD domain; Region: PRD; pfam00874 405955011758 PRD domain; Region: PRD; pfam00874 405955011759 transcriptional regulator PhoU; Provisional; Region: PRK11115 405955011760 PhoU domain; Region: PhoU; pfam01895 405955011761 PhoU domain; Region: PhoU; pfam01895 405955011762 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 405955011763 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 405955011764 Walker A/P-loop; other site 405955011765 ATP binding site [chemical binding]; other site 405955011766 Q-loop/lid; other site 405955011767 ABC transporter signature motif; other site 405955011768 Walker B; other site 405955011769 D-loop; other site 405955011770 H-loop/switch region; other site 405955011771 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 405955011772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955011773 dimer interface [polypeptide binding]; other site 405955011774 conserved gate region; other site 405955011775 putative PBP binding loops; other site 405955011776 ABC-ATPase subunit interface; other site 405955011777 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 405955011778 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955011779 dimer interface [polypeptide binding]; other site 405955011780 conserved gate region; other site 405955011781 putative PBP binding loops; other site 405955011782 ABC-ATPase subunit interface; other site 405955011783 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955011784 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 405955011785 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 405955011786 glutaminase active site [active] 405955011787 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 405955011788 dimer interface [polypeptide binding]; other site 405955011789 active site 405955011790 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 405955011791 dimer interface [polypeptide binding]; other site 405955011792 active site 405955011793 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 405955011794 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 405955011795 Substrate binding site; other site 405955011796 Mg++ binding site; other site 405955011797 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 405955011798 active site 405955011799 substrate binding site [chemical binding]; other site 405955011800 CoA binding site [chemical binding]; other site 405955011801 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 405955011802 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 405955011803 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 405955011804 alpha subunit interaction interface [polypeptide binding]; other site 405955011805 Walker A motif; other site 405955011806 ATP binding site [chemical binding]; other site 405955011807 Walker B motif; other site 405955011808 inhibitor binding site; inhibition site 405955011809 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 405955011810 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 405955011811 core domain interface [polypeptide binding]; other site 405955011812 delta subunit interface [polypeptide binding]; other site 405955011813 epsilon subunit interface [polypeptide binding]; other site 405955011814 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 405955011815 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 405955011816 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 405955011817 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 405955011818 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955011819 S-adenosylmethionine binding site [chemical binding]; other site 405955011820 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 405955011821 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 405955011822 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 405955011823 FMN-binding protein MioC; Provisional; Region: PRK09004 405955011824 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 405955011825 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405955011826 putative DNA binding site [nucleotide binding]; other site 405955011827 putative Zn2+ binding site [ion binding]; other site 405955011828 AsnC family; Region: AsnC_trans_reg; pfam01037 405955011829 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 405955011830 dimer interface [polypeptide binding]; other site 405955011831 active site 405955011832 hypothetical protein; Provisional; Region: yieM; PRK10997 405955011833 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 405955011834 metal ion-dependent adhesion site (MIDAS); other site 405955011835 regulatory ATPase RavA; Provisional; Region: PRK13531 405955011836 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955011837 Walker A motif; other site 405955011838 ATP binding site [chemical binding]; other site 405955011839 Walker B motif; other site 405955011840 arginine finger; other site 405955011841 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 405955011842 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 405955011843 potassium uptake protein; Region: kup; TIGR00794 405955011844 D-ribose pyranase; Provisional; Region: PRK11797 405955011845 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 405955011846 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405955011847 Walker A/P-loop; other site 405955011848 ATP binding site [chemical binding]; other site 405955011849 Q-loop/lid; other site 405955011850 ABC transporter signature motif; other site 405955011851 Walker B; other site 405955011852 D-loop; other site 405955011853 H-loop/switch region; other site 405955011854 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405955011855 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405955011856 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405955011857 TM-ABC transporter signature motif; other site 405955011858 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 405955011859 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 405955011860 ligand binding site [chemical binding]; other site 405955011861 dimerization interface [polypeptide binding]; other site 405955011862 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 405955011863 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405955011864 substrate binding site [chemical binding]; other site 405955011865 dimer interface [polypeptide binding]; other site 405955011866 ATP binding site [chemical binding]; other site 405955011867 transcriptional repressor RbsR; Provisional; Region: PRK10423 405955011868 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955011869 DNA binding site [nucleotide binding] 405955011870 domain linker motif; other site 405955011871 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 405955011872 dimerization interface [polypeptide binding]; other site 405955011873 ligand binding site [chemical binding]; other site 405955011874 putative transporter; Provisional; Region: PRK10504 405955011875 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955011876 putative substrate translocation pore; other site 405955011877 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955011878 Transcriptional regulators [Transcription]; Region: FadR; COG2186 405955011879 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955011880 DNA-binding site [nucleotide binding]; DNA binding site 405955011881 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 405955011882 transcriptional regulator HdfR; Provisional; Region: PRK03601 405955011883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955011884 LysR substrate binding domain; Region: LysR_substrate; pfam03466 405955011885 dimerization interface [polypeptide binding]; other site 405955011886 hypothetical protein; Provisional; Region: PRK11027 405955011887 putative ATP-dependent protease; Provisional; Region: PRK09862 405955011888 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 405955011889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955011890 Walker A motif; other site 405955011891 ATP binding site [chemical binding]; other site 405955011892 Walker B motif; other site 405955011893 arginine finger; other site 405955011894 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 405955011895 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 405955011896 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405955011897 PYR/PP interface [polypeptide binding]; other site 405955011898 dimer interface [polypeptide binding]; other site 405955011899 TPP binding site [chemical binding]; other site 405955011900 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405955011901 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 405955011902 TPP-binding site [chemical binding]; other site 405955011903 dimer interface [polypeptide binding]; other site 405955011904 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 405955011905 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 405955011906 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 405955011907 homodimer interface [polypeptide binding]; other site 405955011908 substrate-cofactor binding pocket; other site 405955011909 catalytic residue [active] 405955011910 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 405955011911 threonine dehydratase; Reviewed; Region: PRK09224 405955011912 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 405955011913 tetramer interface [polypeptide binding]; other site 405955011914 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955011915 catalytic residue [active] 405955011916 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 405955011917 putative Ile/Val binding site [chemical binding]; other site 405955011918 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 405955011919 putative Ile/Val binding site [chemical binding]; other site 405955011920 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955011921 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 405955011922 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 405955011923 putative dimerization interface [polypeptide binding]; other site 405955011924 ketol-acid reductoisomerase; Validated; Region: PRK05225 405955011925 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 405955011926 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 405955011927 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 405955011928 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 405955011929 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 405955011930 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 405955011931 Part of AAA domain; Region: AAA_19; pfam13245 405955011932 Family description; Region: UvrD_C_2; pfam13538 405955011933 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 405955011934 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 405955011935 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 405955011936 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 405955011937 ATP binding site [chemical binding]; other site 405955011938 Mg++ binding site [ion binding]; other site 405955011939 motif III; other site 405955011940 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405955011941 nucleotide binding region [chemical binding]; other site 405955011942 ATP-binding site [chemical binding]; other site 405955011943 transcription termination factor Rho; Provisional; Region: rho; PRK09376 405955011944 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 405955011945 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 405955011946 RNA binding site [nucleotide binding]; other site 405955011947 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 405955011948 multimer interface [polypeptide binding]; other site 405955011949 Walker A motif; other site 405955011950 ATP binding site [chemical binding]; other site 405955011951 Walker B motif; other site 405955011952 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 405955011953 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 405955011954 Mg++ binding site [ion binding]; other site 405955011955 putative catalytic motif [active] 405955011956 substrate binding site [chemical binding]; other site 405955011957 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 405955011958 Chain length determinant protein; Region: Wzz; pfam02706 405955011959 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 405955011960 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 405955011961 active site 405955011962 homodimer interface [polypeptide binding]; other site 405955011963 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 405955011964 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 405955011965 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 405955011966 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 405955011967 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 405955011968 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 405955011969 NAD binding site [chemical binding]; other site 405955011970 substrate binding site [chemical binding]; other site 405955011971 homodimer interface [polypeptide binding]; other site 405955011972 active site 405955011973 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 405955011974 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 405955011975 substrate binding site; other site 405955011976 tetramer interface; other site 405955011977 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 405955011978 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 405955011979 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 405955011980 inhibitor-cofactor binding pocket; inhibition site 405955011981 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955011982 catalytic residue [active] 405955011983 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 405955011984 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 405955011985 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 405955011986 putative common antigen polymerase; Provisional; Region: PRK02975 405955011987 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 405955011988 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 405955011989 putative transport protein YifK; Provisional; Region: PRK10746 405955011990 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 405955011991 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955011992 FeS/SAM binding site; other site 405955011993 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 405955011994 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 405955011995 Sulfatase; Region: Sulfatase; pfam00884 405955011996 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 405955011997 HemY protein N-terminus; Region: HemY_N; pfam07219 405955011998 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 405955011999 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 405955012000 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 405955012001 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 405955012002 active site 405955012003 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 405955012004 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 405955012005 domain interfaces; other site 405955012006 active site 405955012007 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 405955012008 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 405955012009 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 405955012010 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 405955012011 putative iron binding site [ion binding]; other site 405955012012 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 405955012013 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405955012014 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 405955012015 hypothetical protein; Provisional; Region: PRK10963 405955012016 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 405955012017 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405955012018 active site 405955012019 DNA binding site [nucleotide binding] 405955012020 Int/Topo IB signature motif; other site 405955012021 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 405955012022 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955012023 motif II; other site 405955012024 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 405955012025 Part of AAA domain; Region: AAA_19; pfam13245 405955012026 Family description; Region: UvrD_C_2; pfam13538 405955012027 Uncharacterized conserved protein [Function unknown]; Region: COG1912 405955012028 Predicted periplasmic protein [Function unknown]; Region: COG3698 405955012029 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 405955012030 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 405955012031 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 405955012032 Cl binding site [ion binding]; other site 405955012033 oligomer interface [polypeptide binding]; other site 405955012034 Enterobacterial putative membrane protein (DUF943); Region: DUF943; pfam06092 405955012035 Protein of unknown function (DUF3289); Region: DUF3289; cl11840 405955012036 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 405955012037 EamA-like transporter family; Region: EamA; cl17759 405955012038 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 405955012039 CoenzymeA binding site [chemical binding]; other site 405955012040 subunit interaction site [polypeptide binding]; other site 405955012041 PHB binding site; other site 405955012042 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 405955012043 dimerization interface [polypeptide binding]; other site 405955012044 substrate binding site [chemical binding]; other site 405955012045 active site 405955012046 calcium binding site [ion binding]; other site 405955012047 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 405955012048 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405955012049 ATP binding site [chemical binding]; other site 405955012050 putative Mg++ binding site [ion binding]; other site 405955012051 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 405955012052 nucleotide binding region [chemical binding]; other site 405955012053 ATP-binding site [chemical binding]; other site 405955012054 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 405955012055 Helicase and RNase D C-terminal; Region: HRDC; smart00341 405955012056 threonine efflux system; Provisional; Region: PRK10229 405955012057 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 405955012058 lysophospholipase L2; Provisional; Region: PRK10749 405955012059 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405955012060 putative hydrolase; Provisional; Region: PRK10976 405955012061 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955012062 active site 405955012063 motif I; other site 405955012064 motif II; other site 405955012065 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955012066 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405955012067 EamA-like transporter family; Region: EamA; pfam00892 405955012068 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 405955012069 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955012070 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 405955012071 putative dimerization interface [polypeptide binding]; other site 405955012072 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 405955012073 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 405955012074 THF binding site; other site 405955012075 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 405955012076 substrate binding site [chemical binding]; other site 405955012077 THF binding site; other site 405955012078 zinc-binding site [ion binding]; other site 405955012079 Protein of unknown function (DUF796); Region: DUF796; cl01226 405955012080 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 405955012081 tetramer interface [polypeptide binding]; other site 405955012082 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 405955012083 active site 405955012084 PTS system, N-acetylglucosamine-specific IIBC component; Region: PTS-II-BC-nag; TIGR01998 405955012085 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405955012086 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405955012087 active site turn [active] 405955012088 phosphorylation site [posttranslational modification] 405955012089 transketolase; Reviewed; Region: PRK12753 405955012090 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 405955012091 TPP-binding site [chemical binding]; other site 405955012092 dimer interface [polypeptide binding]; other site 405955012093 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 405955012094 PYR/PP interface [polypeptide binding]; other site 405955012095 dimer interface [polypeptide binding]; other site 405955012096 TPP binding site [chemical binding]; other site 405955012097 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 405955012098 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 405955012099 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 405955012100 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 405955012101 putative active site [active] 405955012102 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 405955012103 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955012104 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 405955012105 dimerization interface [polypeptide binding]; other site 405955012106 Solute carrier families 5 and 6-like; solute binding domain; Region: SLC5-6-like_sbd; cl00456 405955012107 Na binding site [ion binding]; other site 405955012108 allophanate hydrolase; Provisional; Region: PRK08186 405955012109 carbamate kinase; Reviewed; Region: PRK12686 405955012110 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 405955012111 putative substrate binding site [chemical binding]; other site 405955012112 nucleotide binding site [chemical binding]; other site 405955012113 nucleotide binding site [chemical binding]; other site 405955012114 homodimer interface [polypeptide binding]; other site 405955012115 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 405955012116 CoA binding domain; Region: CoA_binding; pfam02629 405955012117 CoA-ligase; Region: Ligase_CoA; pfam00549 405955012118 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 405955012119 Isochorismatase family; Region: Isochorismatase; pfam00857 405955012120 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 405955012121 catalytic triad [active] 405955012122 conserved cis-peptide bond; other site 405955012123 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 405955012124 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 405955012125 uridine phosphorylase; Provisional; Region: PRK11178 405955012126 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 405955012127 Tripartite tricarboxylate transporter TctA family; Region: TctA; cl00772 405955012128 Tripartite tricarboxylate transporter TctB family; Region: TctB; pfam07331 405955012129 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3181 405955012130 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 405955012131 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 405955012132 Transcriptional regulator [Transcription]; Region: IclR; COG1414 405955012133 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 405955012134 Bacterial transcriptional regulator; Region: IclR; pfam01614 405955012135 DNA recombination protein RmuC; Provisional; Region: PRK10361 405955012136 RmuC family; Region: RmuC; pfam02646 405955012137 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 405955012138 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955012139 S-adenosylmethionine binding site [chemical binding]; other site 405955012140 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 405955012141 SCP-2 sterol transfer family; Region: SCP2; pfam02036 405955012142 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 405955012143 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 405955012144 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 405955012145 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 405955012146 sec-independent translocase; Provisional; Region: PRK01770 405955012147 sec-independent translocase; Provisional; Region: tatB; PRK00404 405955012148 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 405955012149 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 405955012150 active site 405955012151 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 405955012152 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 405955012153 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 405955012154 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 405955012155 FMN reductase; Validated; Region: fre; PRK08051 405955012156 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 405955012157 FAD binding pocket [chemical binding]; other site 405955012158 FAD binding motif [chemical binding]; other site 405955012159 phosphate binding motif [ion binding]; other site 405955012160 beta-alpha-beta structure motif; other site 405955012161 NAD binding pocket [chemical binding]; other site 405955012162 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 405955012163 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 405955012164 dimer interface [polypeptide binding]; other site 405955012165 active site 405955012166 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 405955012167 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405955012168 substrate binding site [chemical binding]; other site 405955012169 oxyanion hole (OAH) forming residues; other site 405955012170 trimer interface [polypeptide binding]; other site 405955012171 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 405955012172 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405955012173 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 405955012174 proline dipeptidase; Provisional; Region: PRK13607 405955012175 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 405955012176 active site 405955012177 hypothetical protein; Provisional; Region: PRK11568 405955012178 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 405955012179 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 405955012180 potassium transporter; Provisional; Region: PRK10750 405955012181 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 405955012182 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 405955012183 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 405955012184 Walker A motif; other site 405955012185 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 405955012186 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 405955012187 GTP binding site; other site 405955012188 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 405955012189 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 405955012190 serine/threonine protein kinase; Provisional; Region: PRK11768 405955012191 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 405955012192 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 405955012193 catalytic residues [active] 405955012194 hinge region; other site 405955012195 alpha helical domain; other site 405955012196 hypothetical protein; Provisional; Region: PRK11367 405955012197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 405955012198 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 405955012199 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 405955012200 putative acyl-acceptor binding pocket; other site 405955012201 DNA polymerase I; Provisional; Region: PRK05755 405955012202 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 405955012203 active site 405955012204 metal binding site 1 [ion binding]; metal-binding site 405955012205 putative 5' ssDNA interaction site; other site 405955012206 metal binding site 3; metal-binding site 405955012207 metal binding site 2 [ion binding]; metal-binding site 405955012208 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 405955012209 putative DNA binding site [nucleotide binding]; other site 405955012210 putative metal binding site [ion binding]; other site 405955012211 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 405955012212 active site 405955012213 catalytic site [active] 405955012214 substrate binding site [chemical binding]; other site 405955012215 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 405955012216 active site 405955012217 DNA binding site [nucleotide binding] 405955012218 catalytic site [active] 405955012219 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 405955012220 G1 box; other site 405955012221 GTP/Mg2+ binding site [chemical binding]; other site 405955012222 Switch I region; other site 405955012223 G2 box; other site 405955012224 G3 box; other site 405955012225 Switch II region; other site 405955012226 G4 box; other site 405955012227 G5 box; other site 405955012228 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 405955012229 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 405955012230 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955012231 FeS/SAM binding site; other site 405955012232 HemN C-terminal domain; Region: HemN_C; pfam06969 405955012233 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 405955012234 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955012235 active site 405955012236 phosphorylation site [posttranslational modification] 405955012237 intermolecular recognition site; other site 405955012238 dimerization interface [polypeptide binding]; other site 405955012239 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955012240 Walker A motif; other site 405955012241 ATP binding site [chemical binding]; other site 405955012242 Walker B motif; other site 405955012243 arginine finger; other site 405955012244 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405955012245 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 405955012246 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 405955012247 putative active site [active] 405955012248 heme pocket [chemical binding]; other site 405955012249 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955012250 dimer interface [polypeptide binding]; other site 405955012251 phosphorylation site [posttranslational modification] 405955012252 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955012253 ATP binding site [chemical binding]; other site 405955012254 Mg2+ binding site [ion binding]; other site 405955012255 G-X-G motif; other site 405955012256 glutamine synthetase; Provisional; Region: glnA; PRK09469 405955012257 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 405955012258 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 405955012259 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 405955012260 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 405955012261 G1 box; other site 405955012262 putative GEF interaction site [polypeptide binding]; other site 405955012263 GTP/Mg2+ binding site [chemical binding]; other site 405955012264 Switch I region; other site 405955012265 G2 box; other site 405955012266 G3 box; other site 405955012267 Switch II region; other site 405955012268 G4 box; other site 405955012269 G5 box; other site 405955012270 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 405955012271 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 405955012272 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 405955012273 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 405955012274 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405955012275 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 405955012276 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 405955012277 substrate binding site [chemical binding]; other site 405955012278 ATP binding site [chemical binding]; other site 405955012279 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 405955012280 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405955012281 Class I aldolases; Region: Aldolase_Class_I; cl17187 405955012282 catalytic residue [active] 405955012283 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 405955012284 putative oxidoreductase; Provisional; Region: PRK10083 405955012285 NAD(P) binding site [chemical binding]; other site 405955012286 benzoate transport; Region: 2A0115; TIGR00895 405955012287 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955012288 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955012289 shikimate transporter; Provisional; Region: PRK09952 405955012290 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955012291 putative substrate translocation pore; other site 405955012292 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 405955012293 active site 405955012294 catalytic residues [active] 405955012295 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 405955012296 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955012297 motif II; other site 405955012298 hypothetical protein; Reviewed; Region: PRK01637 405955012299 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 405955012300 putative active site [active] 405955012301 dimerization interface [polypeptide binding]; other site 405955012302 putative tRNAtyr binding site [nucleotide binding]; other site 405955012303 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405955012304 Coenzyme A binding pocket [chemical binding]; other site 405955012305 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 405955012306 Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These...; Region: Esterase_lipase; cd00312 405955012307 alpha/beta hydrolase fold; Region: Abhydrolase_3; pfam07859 405955012308 substrate binding pocket [chemical binding]; other site 405955012309 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955012310 non-specific DNA binding site [nucleotide binding]; other site 405955012311 salt bridge; other site 405955012312 sequence-specific DNA binding site [nucleotide binding]; other site 405955012313 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 405955012314 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 405955012315 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 405955012316 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 405955012317 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 405955012318 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 405955012319 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405955012320 molybdopterin cofactor binding site; other site 405955012321 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 405955012322 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 405955012323 molybdopterin cofactor binding site; other site 405955012324 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405955012325 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 405955012326 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 405955012327 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 405955012328 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 405955012329 intersubunit interface [polypeptide binding]; other site 405955012330 active site 405955012331 Zn2+ binding site [ion binding]; other site 405955012332 L-rhamnose isomerase; Provisional; Region: PRK01076 405955012333 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 405955012334 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 405955012335 N- and C-terminal domain interface [polypeptide binding]; other site 405955012336 active site 405955012337 putative catalytic site [active] 405955012338 metal binding site [ion binding]; metal-binding site 405955012339 ATP binding site [chemical binding]; other site 405955012340 rhamnulokinase; Provisional; Region: rhaB; PRK10640 405955012341 carbohydrate binding site [chemical binding]; other site 405955012342 transcriptional activator RhaS; Provisional; Region: PRK13503 405955012343 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 405955012344 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955012345 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955012346 transcriptional activator RhaR; Provisional; Region: PRK13500 405955012347 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 405955012348 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955012349 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955012350 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 405955012351 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 405955012352 superoxide dismutase; Provisional; Region: PRK10925 405955012353 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 405955012354 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 405955012355 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 405955012356 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 405955012357 MOSC domain; Region: MOSC; pfam03473 405955012358 3-alpha domain; Region: 3-alpha; pfam03475 405955012359 two-component sensor protein; Provisional; Region: cpxA; PRK09470 405955012360 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405955012361 dimerization interface [polypeptide binding]; other site 405955012362 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955012363 dimer interface [polypeptide binding]; other site 405955012364 phosphorylation site [posttranslational modification] 405955012365 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955012366 ATP binding site [chemical binding]; other site 405955012367 Mg2+ binding site [ion binding]; other site 405955012368 G-X-G motif; other site 405955012369 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 405955012370 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955012371 active site 405955012372 intermolecular recognition site; other site 405955012373 dimerization interface [polypeptide binding]; other site 405955012374 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955012375 DNA binding site [nucleotide binding] 405955012376 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 405955012377 dimer interface [polypeptide binding]; other site 405955012378 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 405955012379 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 405955012380 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 405955012381 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 405955012382 active site 405955012383 ADP/pyrophosphate binding site [chemical binding]; other site 405955012384 dimerization interface [polypeptide binding]; other site 405955012385 allosteric effector site; other site 405955012386 fructose-1,6-bisphosphate binding site; other site 405955012387 sulfate transporter subunit; Provisional; Region: PRK10752 405955012388 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 405955012389 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 405955012390 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 405955012391 triosephosphate isomerase; Provisional; Region: PRK14567 405955012392 substrate binding site [chemical binding]; other site 405955012393 dimer interface [polypeptide binding]; other site 405955012394 catalytic triad [active] 405955012395 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 405955012396 Predicted membrane protein [Function unknown]; Region: COG3152 405955012397 hypothetical protein; Provisional; Region: PRK09981 405955012398 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 405955012399 Ligand Binding Site [chemical binding]; other site 405955012400 ferredoxin-NADP reductase; Provisional; Region: PRK10926 405955012401 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 405955012402 FAD binding pocket [chemical binding]; other site 405955012403 FAD binding motif [chemical binding]; other site 405955012404 phosphate binding motif [ion binding]; other site 405955012405 beta-alpha-beta structure motif; other site 405955012406 NAD binding pocket [chemical binding]; other site 405955012407 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 405955012408 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 405955012409 putative active site [active] 405955012410 glycerol kinase; Provisional; Region: glpK; PRK00047 405955012411 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 405955012412 N- and C-terminal domain interface [polypeptide binding]; other site 405955012413 active site 405955012414 MgATP binding site [chemical binding]; other site 405955012415 catalytic site [active] 405955012416 metal binding site [ion binding]; metal-binding site 405955012417 glycerol binding site [chemical binding]; other site 405955012418 homotetramer interface [polypeptide binding]; other site 405955012419 homodimer interface [polypeptide binding]; other site 405955012420 FBP binding site [chemical binding]; other site 405955012421 protein IIAGlc interface [polypeptide binding]; other site 405955012422 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 405955012423 amphipathic channel; other site 405955012424 Asn-Pro-Ala signature motifs; other site 405955012425 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 405955012426 UbiA prenyltransferase family; Region: UbiA; pfam01040 405955012427 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 405955012428 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955012429 Walker A motif; other site 405955012430 ATP binding site [chemical binding]; other site 405955012431 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 405955012432 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 405955012433 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 405955012434 active site 405955012435 HslU subunit interaction site [polypeptide binding]; other site 405955012436 essential cell division protein FtsN; Provisional; Region: PRK10927 405955012437 cell division protein FtsN; Provisional; Region: PRK12757 405955012438 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955012439 DNA binding site [nucleotide binding] 405955012440 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 405955012441 domain linker motif; other site 405955012442 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 405955012443 dimerization interface [polypeptide binding]; other site 405955012444 ligand binding site [chemical binding]; other site 405955012445 primosome assembly protein PriA; Validated; Region: PRK05580 405955012446 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405955012447 ATP binding site [chemical binding]; other site 405955012448 putative Mg++ binding site [ion binding]; other site 405955012449 helicase superfamily c-terminal domain; Region: HELICc; smart00490 405955012450 ATP-binding site [chemical binding]; other site 405955012451 hypothetical protein; Provisional; Region: PRK10030 405955012452 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 405955012453 dimerization interface [polypeptide binding]; other site 405955012454 DNA binding site [nucleotide binding] 405955012455 corepressor binding sites; other site 405955012456 cystathionine gamma-synthase; Provisional; Region: PRK08045 405955012457 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 405955012458 homodimer interface [polypeptide binding]; other site 405955012459 substrate-cofactor binding pocket; other site 405955012460 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955012461 catalytic residue [active] 405955012462 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 405955012463 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 405955012464 putative catalytic residues [active] 405955012465 putative nucleotide binding site [chemical binding]; other site 405955012466 putative aspartate binding site [chemical binding]; other site 405955012467 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 405955012468 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 405955012469 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 405955012470 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 405955012471 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405955012472 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 405955012473 active site 405955012474 metal binding site [ion binding]; metal-binding site 405955012475 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405955012476 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405955012477 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 405955012478 active site 405955012479 metal binding site [ion binding]; metal-binding site 405955012480 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405955012481 5'-nucleotidase/2',3'-cyclic phosphodiesterase and related esterases [Nucleotide transport and metabolism]; Region: UshA; COG0737 405955012482 Escherichia coli UshA-like family, N-terminal metallophosphatase domain; Region: MPP_UshA_N_like; cd00845 405955012483 active site 405955012484 metal binding site [ion binding]; metal-binding site 405955012485 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405955012486 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 405955012487 FAD binding site [chemical binding]; other site 405955012488 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 405955012489 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 405955012490 heme binding site [chemical binding]; other site 405955012491 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 405955012492 EamA-like transporter family; Region: EamA; pfam00892 405955012493 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 405955012494 EamA-like transporter family; Region: EamA; pfam00892 405955012495 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 405955012496 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 405955012497 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 405955012498 dimer interface [polypeptide binding]; other site 405955012499 active site 405955012500 metal binding site [ion binding]; metal-binding site 405955012501 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 405955012502 active site 405955012503 intersubunit interactions; other site 405955012504 catalytic residue [active] 405955012505 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405955012506 dimerization domain swap beta strand [polypeptide binding]; other site 405955012507 regulatory protein interface [polypeptide binding]; other site 405955012508 active site 405955012509 regulatory phosphorylation site [posttranslational modification]; other site 405955012510 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 405955012511 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 405955012512 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405955012513 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 405955012514 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 405955012515 active site 405955012516 phosphorylation site [posttranslational modification] 405955012517 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 405955012518 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 405955012519 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 405955012520 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 405955012521 dimer interface [polypeptide binding]; other site 405955012522 active site 405955012523 glycine loop; other site 405955012524 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955012525 FeS/SAM binding site; other site 405955012526 pyruvate formate lyase II activase; Provisional; Region: PRK10076 405955012527 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 405955012528 active site 405955012529 P-loop; other site 405955012530 phosphorylation site [posttranslational modification] 405955012531 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405955012532 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955012533 hypothetical protein; Provisional; Region: PRK10649 405955012534 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 405955012535 Sulfatase; Region: Sulfatase; pfam00884 405955012536 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 405955012537 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 405955012538 acetylornithine deacetylase; Provisional; Region: PRK05111 405955012539 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 405955012540 metal binding site [ion binding]; metal-binding site 405955012541 putative dimer interface [polypeptide binding]; other site 405955012542 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 405955012543 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 405955012544 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 405955012545 nucleotide binding site [chemical binding]; other site 405955012546 N-acetyl-L-glutamate binding site [chemical binding]; other site 405955012547 argininosuccinate lyase; Provisional; Region: PRK04833 405955012548 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 405955012549 active sites [active] 405955012550 tetramer interface [polypeptide binding]; other site 405955012551 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 405955012552 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 405955012553 putative active site pocket [active] 405955012554 putative metal binding site [ion binding]; other site 405955012555 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955012556 D-galactonate transporter; Region: 2A0114; TIGR00893 405955012557 putative substrate translocation pore; other site 405955012558 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 405955012559 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955012560 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 405955012561 dimerization interface [polypeptide binding]; other site 405955012562 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 405955012563 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955012564 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405955012565 Metal-dependent amidase/aminoacylase/carboxypeptidase [General function prediction only]; Region: AbgB; COG1473 405955012566 M20 Peptidase Aminoacylase 1 subfamily; Region: M20_Acy1_like1; cd05666 405955012567 metal binding site [ion binding]; metal-binding site 405955012568 putative dimer interface [polypeptide binding]; other site 405955012569 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955012570 metabolite-proton symporter; Region: 2A0106; TIGR00883 405955012571 putative substrate translocation pore; other site 405955012572 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 405955012573 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955012574 hypothetical protein; Provisional; Region: PRK11056 405955012575 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 405955012576 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955012577 S-adenosylmethionine binding site [chemical binding]; other site 405955012578 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 405955012579 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 405955012580 N-terminal plug; other site 405955012581 ligand-binding site [chemical binding]; other site 405955012582 glutamate racemase; Provisional; Region: PRK00865 405955012583 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 405955012584 FAD binding domain; Region: FAD_binding_4; pfam01565 405955012585 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 405955012586 Biotin operon repressor [Transcription]; Region: BirA; COG1654 405955012587 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 405955012588 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 405955012589 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 405955012590 pantothenate kinase; Provisional; Region: PRK05439 405955012591 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 405955012592 ATP-binding site [chemical binding]; other site 405955012593 CoA-binding site [chemical binding]; other site 405955012594 Mg2+-binding site [ion binding]; other site 405955012595 elongation factor Tu; Reviewed; Region: PRK00049 405955012596 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 405955012597 G1 box; other site 405955012598 GEF interaction site [polypeptide binding]; other site 405955012599 GTP/Mg2+ binding site [chemical binding]; other site 405955012600 Switch I region; other site 405955012601 G2 box; other site 405955012602 G3 box; other site 405955012603 Switch II region; other site 405955012604 G4 box; other site 405955012605 G5 box; other site 405955012606 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 405955012607 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 405955012608 Antibiotic Binding Site [chemical binding]; other site 405955012609 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 405955012610 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 405955012611 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 405955012612 putative homodimer interface [polypeptide binding]; other site 405955012613 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 405955012614 heterodimer interface [polypeptide binding]; other site 405955012615 homodimer interface [polypeptide binding]; other site 405955012616 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 405955012617 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 405955012618 23S rRNA interface [nucleotide binding]; other site 405955012619 L7/L12 interface [polypeptide binding]; other site 405955012620 putative thiostrepton binding site; other site 405955012621 L25 interface [polypeptide binding]; other site 405955012622 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 405955012623 mRNA/rRNA interface [nucleotide binding]; other site 405955012624 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 405955012625 23S rRNA interface [nucleotide binding]; other site 405955012626 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 405955012627 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 405955012628 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 405955012629 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 405955012630 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 405955012631 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 405955012632 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 405955012633 RPB3 interaction site [polypeptide binding]; other site 405955012634 RPB1 interaction site [polypeptide binding]; other site 405955012635 RPB11 interaction site [polypeptide binding]; other site 405955012636 RPB10 interaction site [polypeptide binding]; other site 405955012637 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 405955012638 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 405955012639 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 405955012640 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 405955012641 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 405955012642 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 405955012643 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 405955012644 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 405955012645 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 405955012646 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 405955012647 DNA binding site [nucleotide binding] 405955012648 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 405955012649 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 405955012650 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955012651 FeS/SAM binding site; other site 405955012652 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 405955012653 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 405955012654 ThiS interaction site; other site 405955012655 putative active site [active] 405955012656 tetramer interface [polypeptide binding]; other site 405955012657 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 405955012658 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 405955012659 ATP binding site [chemical binding]; other site 405955012660 substrate interface [chemical binding]; other site 405955012661 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 405955012662 thiamine phosphate binding site [chemical binding]; other site 405955012663 active site 405955012664 pyrophosphate binding site [ion binding]; other site 405955012665 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 405955012666 ThiC-associated domain; Region: ThiC-associated; pfam13667 405955012667 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 405955012668 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 405955012669 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 405955012670 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 405955012671 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 405955012672 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 405955012673 putative NADH binding site [chemical binding]; other site 405955012674 putative active site [active] 405955012675 nudix motif; other site 405955012676 putative metal binding site [ion binding]; other site 405955012677 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 405955012678 substrate binding site [chemical binding]; other site 405955012679 active site 405955012680 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 405955012681 Active_site [active] 405955012682 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 405955012683 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 405955012684 IHF dimer interface [polypeptide binding]; other site 405955012685 IHF - DNA interface [nucleotide binding]; other site 405955012686 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 405955012687 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 405955012688 dimer interface [polypeptide binding]; other site 405955012689 sensor protein ZraS; Provisional; Region: PRK10364 405955012690 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955012691 dimer interface [polypeptide binding]; other site 405955012692 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955012693 ATP binding site [chemical binding]; other site 405955012694 Mg2+ binding site [ion binding]; other site 405955012695 G-X-G motif; other site 405955012696 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 405955012697 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955012698 active site 405955012699 phosphorylation site [posttranslational modification] 405955012700 intermolecular recognition site; other site 405955012701 dimerization interface [polypeptide binding]; other site 405955012702 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955012703 Walker A motif; other site 405955012704 ATP binding site [chemical binding]; other site 405955012705 Walker B motif; other site 405955012706 arginine finger; other site 405955012707 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405955012708 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 405955012709 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 405955012710 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 405955012711 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 405955012712 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 405955012713 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 405955012714 purine monophosphate binding site [chemical binding]; other site 405955012715 dimer interface [polypeptide binding]; other site 405955012716 putative catalytic residues [active] 405955012717 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 405955012718 hypothetical protein; Provisional; Region: PRK10039 405955012719 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 405955012720 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405955012721 Coenzyme A binding pocket [chemical binding]; other site 405955012722 homoserine O-succinyltransferase; Provisional; Region: PRK05368 405955012723 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 405955012724 proposed active site lysine [active] 405955012725 conserved cys residue [active] 405955012726 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 405955012727 malate synthase A; Region: malate_syn_A; TIGR01344 405955012728 active site 405955012729 isocitrate lyase; Provisional; Region: PRK15063 405955012730 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 405955012731 tetramer interface [polypeptide binding]; other site 405955012732 active site 405955012733 Mg2+/Mn2+ binding site [ion binding]; other site 405955012734 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 405955012735 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 405955012736 transcriptional repressor IclR; Provisional; Region: PRK11569 405955012737 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 405955012738 Bacterial transcriptional regulator; Region: IclR; pfam01614 405955012739 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 405955012740 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 405955012741 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 405955012742 substrate binding pocket [chemical binding]; other site 405955012743 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 405955012744 B12 binding site [chemical binding]; other site 405955012745 cobalt ligand [ion binding]; other site 405955012746 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 405955012747 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 405955012748 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 405955012749 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 405955012750 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 405955012751 active site pocket [active] 405955012752 oxyanion hole [active] 405955012753 catalytic triad [active] 405955012754 active site nucleophile [active] 405955012755 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 405955012756 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405955012757 putative NAD(P) binding site [chemical binding]; other site 405955012758 catalytic Zn binding site [ion binding]; other site 405955012759 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 405955012760 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 405955012761 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 405955012762 active site 405955012763 phosphorylation site [posttranslational modification] 405955012764 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 405955012765 active pocket/dimerization site; other site 405955012766 active site 405955012767 phosphorylation site [posttranslational modification] 405955012768 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 405955012769 classical (c) SDRs; Region: SDR_c; cd05233 405955012770 NAD(P) binding site [chemical binding]; other site 405955012771 active site 405955012772 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 405955012773 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 405955012774 putative DNA binding site [nucleotide binding]; other site 405955012775 putative Zn2+ binding site [ion binding]; other site 405955012776 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 405955012777 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 405955012778 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 405955012779 RNA binding surface [nucleotide binding]; other site 405955012780 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 405955012781 probable active site [active] 405955012782 hypothetical protein; Provisional; Region: PRK10515 405955012783 aspartate kinase III; Validated; Region: PRK09084 405955012784 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 405955012785 nucleotide binding site [chemical binding]; other site 405955012786 substrate binding site [chemical binding]; other site 405955012787 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_1; cd04932 405955012788 lysine allosteric regulatory site; other site 405955012789 dimer interface [polypeptide binding]; other site 405955012790 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 405955012791 dimer interface [polypeptide binding]; other site 405955012792 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 405955012793 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 405955012794 active site 405955012795 dimer interface [polypeptide binding]; other site 405955012796 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 405955012797 dimer interface [polypeptide binding]; other site 405955012798 active site 405955012799 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 405955012800 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 405955012801 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 405955012802 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 405955012803 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 405955012804 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955012805 dimer interface [polypeptide binding]; other site 405955012806 conserved gate region; other site 405955012807 putative PBP binding loops; other site 405955012808 ABC-ATPase subunit interface; other site 405955012809 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955012810 dimer interface [polypeptide binding]; other site 405955012811 conserved gate region; other site 405955012812 putative PBP binding loops; other site 405955012813 ABC-ATPase subunit interface; other site 405955012814 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 405955012815 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 405955012816 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 405955012817 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 405955012818 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 405955012819 Walker A/P-loop; other site 405955012820 ATP binding site [chemical binding]; other site 405955012821 Q-loop/lid; other site 405955012822 ABC transporter signature motif; other site 405955012823 Walker B; other site 405955012824 D-loop; other site 405955012825 H-loop/switch region; other site 405955012826 TOBE domain; Region: TOBE_2; pfam08402 405955012827 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 405955012828 trimer interface; other site 405955012829 sugar binding site [chemical binding]; other site 405955012830 maltose regulon periplasmic protein; Provisional; Region: PRK10564 405955012831 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 405955012832 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 405955012833 UbiA prenyltransferase family; Region: UbiA; pfam01040 405955012834 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 405955012835 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 405955012836 putative acyl-acceptor binding pocket; other site 405955012837 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 405955012838 LexA repressor; Validated; Region: PRK00215 405955012839 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 405955012840 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 405955012841 Catalytic site [active] 405955012842 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 405955012843 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 405955012844 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 405955012845 metal binding site 2 [ion binding]; metal-binding site 405955012846 putative DNA binding helix; other site 405955012847 metal binding site 1 [ion binding]; metal-binding site 405955012848 dimer interface [polypeptide binding]; other site 405955012849 structural Zn2+ binding site [ion binding]; other site 405955012850 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 405955012851 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 405955012852 FMN binding site [chemical binding]; other site 405955012853 active site 405955012854 catalytic residues [active] 405955012855 substrate binding site [chemical binding]; other site 405955012856 phage shock protein G; Reviewed; Region: pspG; PRK09459 405955012857 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 405955012858 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 405955012859 NADP binding site [chemical binding]; other site 405955012860 dimer interface [polypeptide binding]; other site 405955012861 L-aspartate oxidase; Provisional; Region: PRK06175 405955012862 FAD binding domain; Region: FAD_binding_2; pfam00890 405955012863 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955012864 metabolite-proton symporter; Region: 2A0106; TIGR00883 405955012865 putative substrate translocation pore; other site 405955012866 3-hydroxybutyryl-CoA dehydratase; Validated; Region: PRK05809 405955012867 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405955012868 substrate binding site [chemical binding]; other site 405955012869 oxyanion hole (OAH) forming residues; other site 405955012870 trimer interface [polypeptide binding]; other site 405955012871 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 405955012872 Coenzyme A transferase; Region: CoA_trans; smart00882 405955012873 Coenzyme A transferase; Region: CoA_trans; cl17247 405955012874 Transcriptional regulators [Transcription]; Region: PurR; COG1609 405955012875 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955012876 DNA binding site [nucleotide binding] 405955012877 domain linker motif; other site 405955012878 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 405955012879 putative dimerization interface [polypeptide binding]; other site 405955012880 putative ligand binding site [chemical binding]; other site 405955012881 replicative DNA helicase; Provisional; Region: PRK08006 405955012882 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 405955012883 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 405955012884 Walker A motif; other site 405955012885 ATP binding site [chemical binding]; other site 405955012886 Walker B motif; other site 405955012887 DNA binding loops [nucleotide binding] 405955012888 alanine racemase; Reviewed; Region: alr; PRK00053 405955012889 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 405955012890 active site 405955012891 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 405955012892 substrate binding site [chemical binding]; other site 405955012893 catalytic residues [active] 405955012894 dimer interface [polypeptide binding]; other site 405955012895 Nicotinamide mononucleotide transporter; Region: NMN_transporter; pfam04973 405955012896 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 405955012897 active site 405955012898 nucleotide binding site [chemical binding]; other site 405955012899 HIGH motif; other site 405955012900 KMSKS motif; other site 405955012901 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 405955012902 AAA domain; Region: AAA_28; pfam13521 405955012903 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 405955012904 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 405955012905 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955012906 homodimer interface [polypeptide binding]; other site 405955012907 catalytic residue [active] 405955012908 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 405955012909 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 405955012910 TPP-binding site [chemical binding]; other site 405955012911 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 405955012912 dimer interface [polypeptide binding]; other site 405955012913 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 405955012914 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 405955012915 E3 interaction surface; other site 405955012916 lipoyl attachment site [posttranslational modification]; other site 405955012917 e3 binding domain; Region: E3_binding; pfam02817 405955012918 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 405955012919 dihydrolipoamide dehydrogenase; Validated; Region: PRK06327 405955012920 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; cl17730 405955012921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 405955012922 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 405955012923 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 405955012924 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 405955012925 CoA-ligase; Region: Ligase_CoA; pfam00549 405955012926 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 405955012927 CoA binding domain; Region: CoA_binding; smart00881 405955012928 CoA-ligase; Region: Ligase_CoA; pfam00549 405955012929 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cl17221 405955012930 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 405955012931 transmembrane helices; other site 405955012932 Malate/L-lactate dehydrogenase; Region: Ldh_2; cl00900 405955012933 Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains [Signal transduction mechanisms]; Region: AtoC; COG2204 405955012934 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955012935 active site 405955012936 phosphorylation site [posttranslational modification] 405955012937 intermolecular recognition site; other site 405955012938 dimerization interface [polypeptide binding]; other site 405955012939 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955012940 Walker A motif; other site 405955012941 ATP binding site [chemical binding]; other site 405955012942 Walker B motif; other site 405955012943 arginine finger; other site 405955012944 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405955012945 Signal transduction histidine kinase regulating C4-dicarboxylate transport system [Signal transduction mechanisms]; Region: COG4191 405955012946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955012947 dimer interface [polypeptide binding]; other site 405955012948 phosphorylation site [posttranslational modification] 405955012949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955012950 ATP binding site [chemical binding]; other site 405955012951 Mg2+ binding site [ion binding]; other site 405955012952 G-X-G motif; other site 405955012953 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955012954 active site 405955012955 motif I; other site 405955012956 motif II; other site 405955012957 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 405955012958 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 405955012959 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 405955012960 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 405955012961 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 405955012962 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 405955012963 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 405955012964 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 405955012965 dimer interface [polypeptide binding]; other site 405955012966 ssDNA binding site [nucleotide binding]; other site 405955012967 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405955012968 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 405955012969 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 405955012970 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 405955012971 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 405955012972 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 405955012973 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 405955012974 DNA binding residues [nucleotide binding] 405955012975 dimer interface [polypeptide binding]; other site 405955012976 [2Fe-2S] cluster binding site [ion binding]; other site 405955012977 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 405955012978 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 405955012979 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 405955012980 Transcriptional regulator [Transcription]; Region: LysR; COG0583 405955012981 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 405955012982 The C-terminal substrate binding domain of LysR-like transcriptional regulator CidR, contains the type 2 periplasmic binding fold; Region: PBP2_CidR; cd08438 405955012983 putative dimerization interface [polypeptide binding]; other site 405955012984 Putative effector of murein hydrolase LrgA [General function prediction only]; Region: COG1380 405955012985 Putative effector of murein hydrolase [Cell envelope biogenesis, outer membrane]; Region: LrgB; COG1346 405955012986 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 405955012987 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 405955012988 Na binding site [ion binding]; other site 405955012989 Predicted membrane protein [Function unknown]; Region: COG3162 405955012990 acetyl-CoA synthetase; Provisional; Region: PRK00174 405955012991 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 405955012992 active site 405955012993 CoA binding site [chemical binding]; other site 405955012994 acyl-activating enzyme (AAE) consensus motif; other site 405955012995 AMP binding site [chemical binding]; other site 405955012996 acetate binding site [chemical binding]; other site 405955012997 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 405955012998 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 405955012999 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 405955013000 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 405955013001 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 405955013002 heme lyase subunit NrfE; Provisional; Region: PRK10369 405955013003 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 405955013004 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 405955013005 binding surface 405955013006 TPR motif; other site 405955013007 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 405955013008 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 405955013009 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 405955013010 Sel1-like repeats; Region: SEL1; smart00671 405955013011 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 405955013012 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955013013 Walker A/P-loop; other site 405955013014 ATP binding site [chemical binding]; other site 405955013015 Q-loop/lid; other site 405955013016 ABC transporter signature motif; other site 405955013017 Walker B; other site 405955013018 D-loop; other site 405955013019 H-loop/switch region; other site 405955013020 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 405955013021 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955013022 Walker A/P-loop; other site 405955013023 ATP binding site [chemical binding]; other site 405955013024 Q-loop/lid; other site 405955013025 ABC transporter signature motif; other site 405955013026 Walker B; other site 405955013027 D-loop; other site 405955013028 H-loop/switch region; other site 405955013029 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppC; COG1173 405955013030 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 405955013031 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955013032 dimer interface [polypeptide binding]; other site 405955013033 conserved gate region; other site 405955013034 ABC-ATPase subunit interface; other site 405955013035 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 405955013036 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955013037 dimer interface [polypeptide binding]; other site 405955013038 conserved gate region; other site 405955013039 putative PBP binding loops; other site 405955013040 ABC-ATPase subunit interface; other site 405955013041 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 405955013042 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 405955013043 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405955013044 molybdopterin cofactor binding site; other site 405955013045 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 405955013046 molybdopterin cofactor binding site; other site 405955013047 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 405955013048 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 405955013049 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 405955013050 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 405955013051 multidrug resistance protein MdtN; Provisional; Region: PRK10476 405955013052 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955013053 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955013054 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 405955013055 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 405955013056 D-allose kinase; Provisional; Region: PRK09698 405955013057 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405955013058 nucleotide binding site [chemical binding]; other site 405955013059 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 405955013060 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 405955013061 substrate binding site [chemical binding]; other site 405955013062 hexamer interface [polypeptide binding]; other site 405955013063 metal binding site [ion binding]; metal-binding site 405955013064 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405955013065 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405955013066 TM-ABC transporter signature motif; other site 405955013067 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 405955013068 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955013069 Walker A/P-loop; other site 405955013070 ATP binding site [chemical binding]; other site 405955013071 Q-loop/lid; other site 405955013072 ABC transporter signature motif; other site 405955013073 Walker B; other site 405955013074 D-loop; other site 405955013075 H-loop/switch region; other site 405955013076 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405955013077 D-allose transporter subunit; Provisional; Region: PRK09701 405955013078 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 405955013079 ligand binding site [chemical binding]; other site 405955013080 dimerization interface [polypeptide binding]; other site 405955013081 zinc binding site [ion binding]; other site 405955013082 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 405955013083 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 405955013084 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 405955013085 putative active site [active] 405955013086 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 405955013087 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 405955013088 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405955013089 Coenzyme A binding pocket [chemical binding]; other site 405955013090 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 405955013091 AAA domain; Region: AAA_18; pfam13238 405955013092 active site 405955013093 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 405955013094 Metal-dependent hydrolase involved in phosphonate metabolism [Inorganic ion transport and metabolism]; Region: COG3454 405955013095 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 405955013096 active site 405955013097 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 405955013098 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405955013099 Walker A/P-loop; other site 405955013100 ATP binding site [chemical binding]; other site 405955013101 Q-loop/lid; other site 405955013102 ABC transporter signature motif; other site 405955013103 Walker B; other site 405955013104 D-loop; other site 405955013105 H-loop/switch region; other site 405955013106 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 405955013107 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 405955013108 Walker A/P-loop; other site 405955013109 ATP binding site [chemical binding]; other site 405955013110 Q-loop/lid; other site 405955013111 ABC transporter signature motif; other site 405955013112 Walker B; other site 405955013113 D-loop; other site 405955013114 H-loop/switch region; other site 405955013115 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 405955013116 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 405955013117 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 405955013118 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 405955013119 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 405955013120 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955013121 DNA-binding site [nucleotide binding]; DNA binding site 405955013122 UTRA domain; Region: UTRA; pfam07702 405955013123 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 405955013124 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 405955013125 dimer interface [polypeptide binding]; other site 405955013126 conserved gate region; other site 405955013127 putative PBP binding loops; other site 405955013128 ABC-ATPase subunit interface; other site 405955013129 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 405955013130 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 405955013131 substrate binding pocket [chemical binding]; other site 405955013132 membrane-bound complex binding site; other site 405955013133 hinge residues; other site 405955013134 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 405955013135 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 405955013136 Walker A/P-loop; other site 405955013137 ATP binding site [chemical binding]; other site 405955013138 Q-loop/lid; other site 405955013139 ABC transporter signature motif; other site 405955013140 Walker B; other site 405955013141 D-loop; other site 405955013142 H-loop/switch region; other site 405955013143 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 405955013144 dimer interface [polypeptide binding]; other site 405955013145 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 405955013146 hypothetical protein; Provisional; Region: PRK09866 405955013147 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 405955013148 G1 box; other site 405955013149 GTP/Mg2+ binding site [chemical binding]; other site 405955013150 G2 box; other site 405955013151 Switch I region; other site 405955013152 G3 box; other site 405955013153 Switch II region; other site 405955013154 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 405955013155 G2 box; other site 405955013156 Switch I region; other site 405955013157 G3 box; other site 405955013158 Switch II region; other site 405955013159 G4 box; other site 405955013160 G5 box; other site 405955013161 YjcZ-like protein; Region: YjcZ; pfam13990 405955013162 proline/glycine betaine transporter; Provisional; Region: PRK10642 405955013163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955013164 putative substrate translocation pore; other site 405955013165 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 405955013166 sensor protein BasS/PmrB; Provisional; Region: PRK10755 405955013167 HAMP domain; Region: HAMP; pfam00672 405955013168 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955013169 dimer interface [polypeptide binding]; other site 405955013170 phosphorylation site [posttranslational modification] 405955013171 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955013172 ATP binding site [chemical binding]; other site 405955013173 Mg2+ binding site [ion binding]; other site 405955013174 G-X-G motif; other site 405955013175 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 405955013176 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955013177 active site 405955013178 phosphorylation site [posttranslational modification] 405955013179 intermolecular recognition site; other site 405955013180 dimerization interface [polypeptide binding]; other site 405955013181 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955013182 DNA binding site [nucleotide binding] 405955013183 putative metal dependent hydrolase; Provisional; Region: PRK11598 405955013184 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 405955013185 Sulfatase; Region: Sulfatase; pfam00884 405955013186 arginine:agmatin antiporter; Provisional; Region: PRK10644 405955013187 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405955013188 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955013189 arginine decarboxylase; Provisional; Region: PRK15029 405955013190 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 405955013191 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 405955013192 homodimer interface [polypeptide binding]; other site 405955013193 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955013194 catalytic residue [active] 405955013195 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405955013196 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 405955013197 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955013198 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955013199 alpha-galactosidase; Provisional; Region: PRK15076 405955013200 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 405955013201 NAD binding site [chemical binding]; other site 405955013202 sugar binding site [chemical binding]; other site 405955013203 divalent metal binding site [ion binding]; other site 405955013204 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 405955013205 dimer interface [polypeptide binding]; other site 405955013206 hypothetical protein; Provisional; Region: PRK09867 405955013207 fumarate hydratase; Provisional; Region: PRK15389 405955013208 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 405955013209 Fumarase C-terminus; Region: Fumerase_C; pfam05683 405955013210 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 405955013211 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 405955013212 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 405955013213 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955013214 active site 405955013215 phosphorylation site [posttranslational modification] 405955013216 intermolecular recognition site; other site 405955013217 dimerization interface [polypeptide binding]; other site 405955013218 Transcriptional regulator; Region: CitT; pfam12431 405955013219 sensory histidine kinase DcuS; Provisional; Region: PRK11086 405955013220 PAS domain; Region: PAS; smart00091 405955013221 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955013222 ATP binding site [chemical binding]; other site 405955013223 Mg2+ binding site [ion binding]; other site 405955013224 G-X-G motif; other site 405955013225 Predicted acetyltransferase [General function prediction only]; Region: COG2388 405955013226 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 405955013227 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 405955013228 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 405955013229 dimer interface [polypeptide binding]; other site 405955013230 putative anticodon binding site; other site 405955013231 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 405955013232 motif 1; other site 405955013233 active site 405955013234 motif 2; other site 405955013235 motif 3; other site 405955013236 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 405955013237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955013238 putative substrate translocation pore; other site 405955013239 POT family; Region: PTR2; pfam00854 405955013240 lysine decarboxylase CadA; Provisional; Region: PRK15400 405955013241 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 405955013242 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 405955013243 homodimer interface [polypeptide binding]; other site 405955013244 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955013245 catalytic residue [active] 405955013246 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405955013247 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 405955013248 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 405955013249 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955013250 DNA binding site [nucleotide binding] 405955013251 Methyltransferase domain; Region: Methyltransf_27; pfam13708 405955013252 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 405955013253 DNA repair proteins [DNA replication, recombination, and repair]; Region: RadC; COG2003 405955013254 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 405955013255 MPN+ (JAMM) motif; other site 405955013256 Zinc-binding site [ion binding]; other site 405955013257 Domain of unknown function (DUF932); Region: DUF932; pfam06067 405955013258 HTH domain; Region: HTH_11; cl17392 405955013259 WYL domain; Region: WYL; pfam13280 405955013260 Predicted GTPase [General function prediction only]; Region: COG3596 405955013261 YfjP GTPase; Region: YfjP; cd11383 405955013262 G1 box; other site 405955013263 GTP/Mg2+ binding site [chemical binding]; other site 405955013264 Switch I region; other site 405955013265 G2 box; other site 405955013266 Switch II region; other site 405955013267 G3 box; other site 405955013268 G4 box; other site 405955013269 G5 box; other site 405955013270 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 405955013271 Transposase; Region: HTH_Tnp_1; cl17663 405955013272 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405955013273 Protein export membrane protein; Region: SecD_SecF; cl14618 405955013274 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955013275 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 405955013276 Hexamer interface [polypeptide binding]; other site 405955013277 Hexagonal pore residue; other site 405955013278 S-adenosylmethionine synthetase; Validated; Region: PRK05250 405955013279 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 405955013280 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 405955013281 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 405955013282 Response regulator receiver domain; Region: Response_reg; pfam00072 405955013283 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955013284 active site 405955013285 phosphorylation site [posttranslational modification] 405955013286 intermolecular recognition site; other site 405955013287 dimerization interface [polypeptide binding]; other site 405955013288 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955013289 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 405955013290 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955013291 Sensory domain found in PocR; Region: PocR; pfam10114 405955013292 Predicted sensor domain [Signal transduction mechanisms / Transcription]; Region: PocR; COG4936 405955013293 Histidine kinase; Region: His_kinase; pfam06580 405955013294 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955013295 ATP binding site [chemical binding]; other site 405955013296 Mg2+ binding site [ion binding]; other site 405955013297 G-X-G motif; other site 405955013298 RT_like: Reverse transcriptase (RT, RNA-dependent DNA polymerase)_like family. An RT gene is usually indicative of a mobile element such as a retrotransposon or retrovirus. RTs occur in a variety of mobile elements, including retrotransposons; Region: RT_like; cl02808 405955013299 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 405955013300 active site 405955013301 nucleic acid binding site [nucleotide binding]; other site 405955013302 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 405955013303 Retron-type reverse transcriptase [DNA replication, recombination, and repair]; Region: COG3344 405955013304 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 405955013305 putative NTP binding site [chemical binding]; other site 405955013306 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 405955013307 4Fe-4S binding domain; Region: Fer4; cl02805 405955013308 4Fe-4S binding domain; Region: Fer4_6; pfam12837 405955013309 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955013310 FeS/SAM binding site; other site 405955013311 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 405955013312 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 405955013313 dimer interface [polypeptide binding]; other site 405955013314 active site 405955013315 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 405955013316 intracellular protease, PfpI family; Region: PfpI; TIGR01382 405955013317 Type 1 glutamine amidotransferase (GATase1)-like domain found in a subgroup of proteins similar to PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_1; cd03169 405955013318 conserved cys residue [active] 405955013319 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 405955013320 putative catalytic cysteine [active] 405955013321 propanediol utilization protein PduB; Provisional; Region: PRK15415 405955013322 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_PduB_repeat1; cd07047 405955013323 putative hexamer interface [polypeptide binding]; other site 405955013324 putative hexagonal pore; other site 405955013325 1,2-propanediol utilization protein B (PduB), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_PduB_repeat2; cd07048 405955013326 putative hexamer interface [polypeptide binding]; other site 405955013327 putative hexagonal pore; other site 405955013328 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 405955013329 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 405955013330 Hexamer interface [polypeptide binding]; other site 405955013331 Hexagonal pore residue; other site 405955013332 propionate/acetate kinase; Provisional; Region: PRK12379 405955013333 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 405955013334 Domain of unknown function (DUF336); Region: DUF336; pfam03928 405955013335 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 405955013336 Hexamer/Pentamer interface [polypeptide binding]; other site 405955013337 central pore; other site 405955013338 Flavoprotein; Region: Flavoprotein; cl08021 405955013339 ethanolamine utilization protein; Region: eut_hyp; TIGR02536 405955013340 ethanolamine utilization protein EutJ family protein; Region: EutJ; TIGR02529 405955013341 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 405955013342 nucleotide binding site [chemical binding]; other site 405955013343 propanediol utilization phosphotransacylase; Provisional; Region: PRK15070 405955013344 Propanediol utilisation protein PduL; Region: PduL; pfam06130 405955013345 Propanediol utilisation protein PduL; Region: PduL; pfam06130 405955013346 Alcohol dehydrogenase, class IV [Energy production and conversion]; Region: EutG; COG1454 405955013347 1,3-propanediol dehydrogenase (PPD) catalyzes the reduction of 3-hydroxypropionaldehyde (3-HPA) to 1,3-propanediol in glycerol metabolism; Region: PDD; cd08180 405955013348 putative active site [active] 405955013349 metal binding site [ion binding]; metal-binding site 405955013350 Hemolysin activation/secretion protein [Intracellular trafficking and secretion]; Region: FhaC; COG2831 405955013351 POTRA domain, ShlB-type; Region: POTRA_2; pfam08479 405955013352 ImpA domain protein; Region: DUF3702; pfam12486 405955013353 Predicted P-loop ATPase [General function prediction only]; Region: COG4928 405955013354 KAP family P-loop domain; Region: KAP_NTPase; pfam07693 405955013355 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 405955013356 active site 405955013357 Nucleotidyltransferase (NT) domain of 2'5'-oligoadenylate (2-5A)synthetase (2-5OAS) and class I CCA-adding enzyme; Region: NT_2-5OAS_ClassI-CCAase; cd05400 405955013358 active site 405955013359 NTP binding site [chemical binding]; other site 405955013360 metal binding triad [ion binding]; metal-binding site 405955013361 putative transposase OrfB; Reviewed; Region: PHA02517 405955013362 HTH-like domain; Region: HTH_21; pfam13276 405955013363 Integrase core domain; Region: rve; pfam00665 405955013364 Integrase core domain; Region: rve_2; pfam13333 405955013365 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405955013366 Transposase; Region: HTH_Tnp_1; pfam01527 405955013367 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 405955013368 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 405955013369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 405955013370 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 405955013371 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 405955013372 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 405955013373 arginine decarboxylase; Provisional; Region: PRK15029 405955013374 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 405955013375 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 405955013376 homodimer interface [polypeptide binding]; other site 405955013377 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955013378 catalytic residue [active] 405955013379 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 405955013380 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 405955013381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 405955013382 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 405955013383 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 405955013384 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 405955013385 MarR family; Region: MarR_2; cl17246 405955013386 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 405955013387 Integrase core domain; Region: rve; pfam00665 405955013388 Integrase core domain; Region: rve_3; cl15866 405955013389 HTH-like domain; Region: HTH_21; pfam13276 405955013390 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 405955013391 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 405955013392 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 405955013393 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 405955013394 integrase; Provisional; Region: PRK09692 405955013395 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 405955013396 active site 405955013397 Int/Topo IB signature motif; other site 405955013398 putative transcriptional regulator; Provisional; Region: PRK11640 405955013399 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955013400 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 405955013401 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 405955013402 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 405955013403 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 405955013404 DsbD alpha interface [polypeptide binding]; other site 405955013405 catalytic residues [active] 405955013406 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 405955013407 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 405955013408 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 405955013409 Aspartase; Region: Aspartase; cd01357 405955013410 active sites [active] 405955013411 tetramer interface [polypeptide binding]; other site 405955013412 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 405955013413 putative transporter; Provisional; Region: PRK11021 405955013414 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 405955013415 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 405955013416 ring oligomerisation interface [polypeptide binding]; other site 405955013417 ATP/Mg binding site [chemical binding]; other site 405955013418 stacking interactions; other site 405955013419 hinge regions; other site 405955013420 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 405955013421 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 405955013422 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955013423 FeS/SAM binding site; other site 405955013424 elongation factor P; Validated; Region: PRK00529 405955013425 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 405955013426 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 405955013427 RNA binding site [nucleotide binding]; other site 405955013428 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 405955013429 RNA binding site [nucleotide binding]; other site 405955013430 multidrug efflux system protein; Provisional; Region: PRK11431 405955013431 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 405955013432 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 405955013433 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 405955013434 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 405955013435 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 405955013436 Iron-sulfur protein interface; other site 405955013437 proximal quinone binding site [chemical binding]; other site 405955013438 C-subunit interface; other site 405955013439 distal quinone binding site; other site 405955013440 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 405955013441 D-subunit interface [polypeptide binding]; other site 405955013442 Iron-sulfur protein interface; other site 405955013443 proximal quinone binding site [chemical binding]; other site 405955013444 distal quinone binding site [chemical binding]; other site 405955013445 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 405955013446 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 405955013447 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 405955013448 L-aspartate oxidase; Provisional; Region: PRK06175 405955013449 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 405955013450 poxB regulator PoxA; Provisional; Region: PRK09350 405955013451 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 405955013452 motif 1; other site 405955013453 dimer interface [polypeptide binding]; other site 405955013454 active site 405955013455 motif 2; other site 405955013456 motif 3; other site 405955013457 inner membrane transporter YjeM; Provisional; Region: PRK15238 405955013458 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 405955013459 putative mechanosensitive channel protein; Provisional; Region: PRK10929 405955013460 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 405955013461 DNA-binding site [nucleotide binding]; DNA binding site 405955013462 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 405955013463 Mechanosensitive ion channel; Region: MS_channel; pfam00924 405955013464 GTPase RsgA; Reviewed; Region: PRK12288 405955013465 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405955013466 RNA binding site [nucleotide binding]; other site 405955013467 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 405955013468 GTPase/Zn-binding domain interface [polypeptide binding]; other site 405955013469 GTP/Mg2+ binding site [chemical binding]; other site 405955013470 G4 box; other site 405955013471 G5 box; other site 405955013472 G1 box; other site 405955013473 Switch I region; other site 405955013474 G2 box; other site 405955013475 G3 box; other site 405955013476 Switch II region; other site 405955013477 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 405955013478 catalytic site [active] 405955013479 putative active site [active] 405955013480 putative substrate binding site [chemical binding]; other site 405955013481 dimer interface [polypeptide binding]; other site 405955013482 epoxyqueuosine reductase; Region: TIGR00276 405955013483 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 405955013484 putative carbohydrate kinase; Provisional; Region: PRK10565 405955013485 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 405955013486 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 405955013487 putative substrate binding site [chemical binding]; other site 405955013488 putative ATP binding site [chemical binding]; other site 405955013489 ADP-binding protein; Provisional; Region: PRK10646 405955013490 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 405955013491 AMIN domain; Region: AMIN; pfam11741 405955013492 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 405955013493 active site 405955013494 metal binding site [ion binding]; metal-binding site 405955013495 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 405955013496 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955013497 ATP binding site [chemical binding]; other site 405955013498 Mg2+ binding site [ion binding]; other site 405955013499 G-X-G motif; other site 405955013500 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 405955013501 ATP binding site [chemical binding]; other site 405955013502 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 405955013503 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 405955013504 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 405955013505 bacterial Hfq-like; Region: Hfq; cd01716 405955013506 hexamer interface [polypeptide binding]; other site 405955013507 Sm1 motif; other site 405955013508 RNA binding site [nucleotide binding]; other site 405955013509 Sm2 motif; other site 405955013510 GTPase HflX; Provisional; Region: PRK11058 405955013511 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 405955013512 HflX GTPase family; Region: HflX; cd01878 405955013513 G1 box; other site 405955013514 GTP/Mg2+ binding site [chemical binding]; other site 405955013515 Switch I region; other site 405955013516 G2 box; other site 405955013517 G3 box; other site 405955013518 Switch II region; other site 405955013519 G4 box; other site 405955013520 G5 box; other site 405955013521 FtsH protease regulator HflK; Provisional; Region: PRK10930 405955013522 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 405955013523 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 405955013524 FtsH protease regulator HflC; Provisional; Region: PRK11029 405955013525 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 405955013526 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 405955013527 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 405955013528 GDP-binding site [chemical binding]; other site 405955013529 ACT binding site; other site 405955013530 IMP binding site; other site 405955013531 Predicted transcriptional regulator [Transcription]; Region: COG1959 405955013532 transcriptional repressor NsrR; Provisional; Region: PRK11014 405955013533 exoribonuclease R; Provisional; Region: PRK11642 405955013534 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 405955013535 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 405955013536 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 405955013537 RNB domain; Region: RNB; pfam00773 405955013538 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 405955013539 RNA binding site [nucleotide binding]; other site 405955013540 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 405955013541 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 405955013542 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 405955013543 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 405955013544 PspA/IM30 family; Region: PspA_IM30; pfam04012 405955013545 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 405955013546 Predicted membrane protein [Function unknown]; Region: COG3766 405955013547 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 405955013548 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 405955013549 Predicted integral membrane protein [Function unknown]; Region: COG5463 405955013550 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 405955013551 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 405955013552 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 405955013553 FAD binding site [chemical binding]; other site 405955013554 substrate binding site [chemical binding]; other site 405955013555 catalytic residues [active] 405955013556 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 405955013557 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 405955013558 esterase; Provisional; Region: PRK10566 405955013559 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 405955013560 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 405955013561 transcriptional repressor UlaR; Provisional; Region: PRK13509 405955013562 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 405955013563 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 405955013564 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 405955013565 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 405955013566 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 405955013567 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 405955013568 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 405955013569 active site 405955013570 dimer interface [polypeptide binding]; other site 405955013571 magnesium binding site [ion binding]; other site 405955013572 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 405955013573 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 405955013574 AP (apurinic/apyrimidinic) site pocket; other site 405955013575 DNA interaction; other site 405955013576 Metal-binding active site; metal-binding site 405955013577 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 405955013578 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 405955013579 intersubunit interface [polypeptide binding]; other site 405955013580 active site 405955013581 Zn2+ binding site [ion binding]; other site 405955013582 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 405955013583 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 405955013584 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 405955013585 dimer interface [polypeptide binding]; other site 405955013586 ssDNA binding site [nucleotide binding]; other site 405955013587 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405955013588 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 405955013589 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 405955013590 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 405955013591 Helix-turn-helix domain; Region: HTH_31; pfam13560 405955013592 sequence-specific DNA binding site [nucleotide binding]; other site 405955013593 salt bridge; other site 405955013594 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 405955013595 HipA-like N-terminal domain; Region: HipA_N; pfam07805 405955013596 HipA-like C-terminal domain; Region: HipA_C; pfam07804 405955013597 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955013598 D-galactonate transporter; Region: 2A0114; TIGR00893 405955013599 putative substrate translocation pore; other site 405955013600 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 405955013601 L-aspartate oxidase; Provisional; Region: PRK06175 405955013602 L-aspartate oxidase; Provisional; Region: PRK06175 405955013603 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 405955013604 Coenzyme A transferase; Region: CoA_trans; smart00882 405955013605 Coenzyme A transferase; Region: CoA_trans; cl17247 405955013606 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 405955013607 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 405955013608 substrate binding site [chemical binding]; other site 405955013609 oxyanion hole (OAH) forming residues; other site 405955013610 trimer interface [polypeptide binding]; other site 405955013611 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 405955013612 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 405955013613 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 405955013614 putative NAD(P) binding site [chemical binding]; other site 405955013615 active site 405955013616 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 405955013617 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955013618 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 405955013619 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 405955013620 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 405955013621 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 405955013622 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 405955013623 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 405955013624 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 405955013625 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 405955013626 Hemerythrin-like domain; Region: Hr-like; cd12108 405955013627 Fe binding site [ion binding]; other site 405955013628 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 405955013629 EamA-like transporter family; Region: EamA; pfam00892 405955013630 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 405955013631 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 405955013632 NADP binding site [chemical binding]; other site 405955013633 Predicted transcriptional regulators [Transcription]; Region: COG1733 405955013634 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 405955013635 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 405955013636 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 405955013637 active site 405955013638 metal binding site [ion binding]; metal-binding site 405955013639 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 405955013640 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 405955013641 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 405955013642 active site 405955013643 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 405955013644 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 405955013645 Domain of unknown function DUF21; Region: DUF21; pfam01595 405955013646 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 405955013647 Transporter associated domain; Region: CorC_HlyC; smart01091 405955013648 methionine sulfoxide reductase A; Provisional; Region: PRK00058 405955013649 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 405955013650 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 405955013651 Surface antigen; Region: Bac_surface_Ag; pfam01103 405955013652 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 405955013653 Family of unknown function (DUF490); Region: DUF490; pfam04357 405955013654 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 405955013655 putative active site pocket [active] 405955013656 dimerization interface [polypeptide binding]; other site 405955013657 putative catalytic residue [active] 405955013658 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 405955013659 dimer interface [polypeptide binding]; other site 405955013660 substrate binding site [chemical binding]; other site 405955013661 metal binding sites [ion binding]; metal-binding site 405955013662 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 405955013663 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 405955013664 putative ligand binding site [chemical binding]; other site 405955013665 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 405955013666 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 405955013667 Walker A/P-loop; other site 405955013668 ATP binding site [chemical binding]; other site 405955013669 Q-loop/lid; other site 405955013670 ABC transporter signature motif; other site 405955013671 Walker B; other site 405955013672 D-loop; other site 405955013673 H-loop/switch region; other site 405955013674 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 405955013675 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405955013676 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405955013677 TM-ABC transporter signature motif; other site 405955013678 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 405955013679 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 405955013680 TM-ABC transporter signature motif; other site 405955013681 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 405955013682 AMP binding site [chemical binding]; other site 405955013683 metal binding site [ion binding]; metal-binding site 405955013684 active site 405955013685 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 405955013686 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 405955013687 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 405955013688 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 405955013689 hypothetical protein; Provisional; Region: PRK05255 405955013690 peptidase PmbA; Provisional; Region: PRK11040 405955013691 cytochrome b562; Provisional; Region: PRK15058 405955013692 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 405955013693 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955013694 FeS/SAM binding site; other site 405955013695 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 405955013696 ATP cone domain; Region: ATP-cone; pfam03477 405955013697 Class III ribonucleotide reductase; Region: RNR_III; cd01675 405955013698 effector binding site; other site 405955013699 active site 405955013700 Zn binding site [ion binding]; other site 405955013701 glycine loop; other site 405955013702 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 405955013703 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 405955013704 Ca binding site [ion binding]; other site 405955013705 active site 405955013706 catalytic site [active] 405955013707 Domain of unknown function (DUF3459); Region: DUF3459; pfam11941 405955013708 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 405955013709 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 405955013710 active site turn [active] 405955013711 phosphorylation site [posttranslational modification] 405955013712 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 405955013713 trehalose repressor; Provisional; Region: treR; PRK09492 405955013714 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955013715 DNA binding site [nucleotide binding] 405955013716 domain linker motif; other site 405955013717 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 405955013718 dimerization interface [polypeptide binding]; other site 405955013719 ligand binding site [chemical binding]; other site 405955013720 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 405955013721 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 405955013722 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405955013723 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 405955013724 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955013725 motif II; other site 405955013726 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 405955013727 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 405955013728 homotrimer interaction site [polypeptide binding]; other site 405955013729 putative active site [active] 405955013730 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 405955013731 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 405955013732 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 405955013733 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 405955013734 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405955013735 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405955013736 Arginine repressor [Transcription]; Region: ArgR; COG1438 405955013737 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 405955013738 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 405955013739 Predicted membrane protein [Function unknown]; Region: COG1288 405955013740 ornithine carbamoyltransferase; Validated; Region: PRK02102 405955013741 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405955013742 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405955013743 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 405955013744 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 405955013745 putative substrate binding site [chemical binding]; other site 405955013746 nucleotide binding site [chemical binding]; other site 405955013747 nucleotide binding site [chemical binding]; other site 405955013748 homodimer interface [polypeptide binding]; other site 405955013749 arginine deiminase; Provisional; Region: PRK01388 405955013750 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 405955013751 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 405955013752 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 405955013753 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 405955013754 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 405955013755 RNase E inhibitor protein; Provisional; Region: PRK11191 405955013756 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 405955013757 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405955013758 Coenzyme A binding pocket [chemical binding]; other site 405955013759 Bacterial protein of unknown function (DUF898); Region: DUF898; cl01738 405955013760 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 405955013761 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 405955013762 HIGH motif; other site 405955013763 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 405955013764 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 405955013765 active site 405955013766 KMSKS motif; other site 405955013767 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 405955013768 tRNA binding surface [nucleotide binding]; other site 405955013769 anticodon binding site; other site 405955013770 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 405955013771 DNA polymerase III subunit chi; Validated; Region: PRK05728 405955013772 multifunctional aminopeptidase A; Provisional; Region: PRK00913 405955013773 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 405955013774 interface (dimer of trimers) [polypeptide binding]; other site 405955013775 Substrate-binding/catalytic site; other site 405955013776 Zn-binding sites [ion binding]; other site 405955013777 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 405955013778 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 405955013779 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 405955013780 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 405955013781 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 405955013782 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 405955013783 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 405955013784 DNA binding site [nucleotide binding] 405955013785 domain linker motif; other site 405955013786 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 405955013787 putative dimerization interface [polypeptide binding]; other site 405955013788 putative ligand binding site [chemical binding]; other site 405955013789 fructuronate transporter; Provisional; Region: PRK10034; cl15264 405955013790 gluconate transporter; Region: gntP; TIGR00791 405955013791 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 405955013792 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 405955013793 NADP binding site [chemical binding]; other site 405955013794 homodimer interface [polypeptide binding]; other site 405955013795 active site 405955013796 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 405955013797 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 405955013798 putative NAD(P) binding site [chemical binding]; other site 405955013799 catalytic Zn binding site [ion binding]; other site 405955013800 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 405955013801 ATP-binding site [chemical binding]; other site 405955013802 Gluconate-6-phosphate binding site [chemical binding]; other site 405955013803 Shikimate kinase; Region: SKI; pfam01202 405955013804 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 405955013805 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 405955013806 putative NAD(P) binding site [chemical binding]; other site 405955013807 putative substrate binding site [chemical binding]; other site 405955013808 catalytic Zn binding site [ion binding]; other site 405955013809 structural Zn binding site [ion binding]; other site 405955013810 dimer interface [polypeptide binding]; other site 405955013811 Predicted restriction endonuclease [Defense mechanisms]; Region: COG3440 405955013812 HNH endonuclease; Region: HNH_2; pfam13391 405955013813 Domain of unknown function (DUF303); Region: DUF303; pfam03629 405955013814 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 405955013815 Kelch motif; Region: Kelch_1; pfam01344 405955013816 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 405955013817 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 405955013818 Int/Topo IB signature motif; other site 405955013819 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 405955013820 Int/Topo IB signature motif; other site 405955013821 Fimbrial protein; Region: Fimbrial; cl01416 405955013822 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 405955013823 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 405955013824 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 405955013825 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 405955013826 outer membrane usher protein; Provisional; Region: PRK15193 405955013827 PapC N-terminal domain; Region: PapC_N; pfam13954 405955013828 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 405955013829 PapC C-terminal domain; Region: PapC_C; pfam13953 405955013830 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 405955013831 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 405955013832 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 405955013833 mannosyl binding site [chemical binding]; other site 405955013834 Fimbrial protein; Region: Fimbrial; pfam00419 405955013835 mannonate dehydratase; Region: uxuA; TIGR00695 405955013836 mannonate dehydratase; Provisional; Region: PRK03906 405955013837 D-mannonate oxidoreductase; Provisional; Region: PRK15037 405955013838 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 405955013839 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 405955013840 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 405955013841 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955013842 DNA-binding site [nucleotide binding]; DNA binding site 405955013843 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 405955013844 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 405955013845 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 405955013846 dihydroxyacetone kinase, phosphotransfer subunit; Region: dha_pts; TIGR02364 405955013847 active pocket/dimerization site; other site 405955013848 active site 405955013849 phosphorylation site [posttranslational modification] 405955013850 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 405955013851 dimerization domain swap beta strand [polypeptide binding]; other site 405955013852 regulatory protein interface [polypeptide binding]; other site 405955013853 active site 405955013854 regulatory phosphorylation site [posttranslational modification]; other site 405955013855 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 405955013856 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 405955013857 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 405955013858 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 405955013859 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 405955013860 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 405955013861 Dak1 domain; Region: Dak1; pfam02733 405955013862 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 405955013863 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 405955013864 dimer interface [polypeptide binding]; other site 405955013865 active site 405955013866 metal binding site [ion binding]; metal-binding site 405955013867 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955013868 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405955013869 putative substrate translocation pore; other site 405955013870 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 405955013871 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405955013872 BCCT family transporter; Region: BCCT; pfam02028 405955013873 glycerate kinase; Region: TIGR00045 405955013874 tartronate semialdehyde reductase; Provisional; Region: PRK15059 405955013875 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 405955013876 hydroxypyruvate isomerase; Region: OH-pyruv-isom; TIGR03234 405955013877 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 405955013878 glyoxylate carboligase; Provisional; Region: PRK11269 405955013879 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 405955013880 PYR/PP interface [polypeptide binding]; other site 405955013881 dimer interface [polypeptide binding]; other site 405955013882 TPP binding site [chemical binding]; other site 405955013883 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 405955013884 Thiamine pyrophosphate (TPP) enzyme family, TPP-binding module; found in many key metabolic enzymes which use TPP (also known as thiamine diphosphate) as a cofactor. These enzymes include, among others, the E1 components of the pyruvate, the acetoin and...; Region: TPP_enzymes; cl01629 405955013885 TPP-binding site [chemical binding]; other site 405955013886 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 405955013887 GAF domain; Region: GAF; pfam01590 405955013888 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cl02459 405955013889 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955013890 Walker A motif; other site 405955013891 ATP binding site [chemical binding]; other site 405955013892 Walker B motif; other site 405955013893 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 405955013894 FAD dependent oxidoreductase; Region: FAD_oxidored; pfam12831 405955013895 Na+/H+ antiporter NhaC; Region: antiport_nhaC; TIGR00931 405955013896 cell density-dependent motility repressor; Provisional; Region: PRK10082 405955013897 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 405955013898 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 405955013899 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 405955013900 dimer interface [polypeptide binding]; other site 405955013901 active site 405955013902 hypothetical protein; Provisional; Region: PRK10519 405955013903 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 405955013904 Nucleoside recognition; Region: Gate; pfam07670 405955013905 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 405955013906 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 405955013907 Protein of unknown function (DUF1228); Region: DUF1228; pfam06779 405955013908 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 405955013909 SdiA-regulated; Region: SdiA-regulated; cd09971 405955013910 putative active site [active] 405955013911 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 405955013912 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 405955013913 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 405955013914 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 405955013915 Predicted membrane protein [Function unknown]; Region: COG2733 405955013916 putative transposase; Provisional; Region: PRK09857 405955013917 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 405955013918 Uncharacterized conserved protein [Function unknown]; Region: COG1479 405955013919 Protein of unknown function DUF262; Region: DUF262; pfam03235 405955013920 Protein of unknown function DUF262; Region: DUF262; pfam03235 405955013921 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 405955013922 Uncharacterized conserved protein [Function unknown]; Region: COG3586 405955013923 endoribonuclease SymE; Provisional; Region: PRK13605 405955013924 EcoKI restriction-modification system protein HsdS; Provisional; Region: PRK09737 405955013925 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 405955013926 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 405955013927 HsdM N-terminal domain; Region: HsdM_N; pfam12161 405955013928 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 405955013929 Methyltransferase domain; Region: Methyltransf_26; pfam13659 405955013930 type I restriction enzyme EcoKI subunit R; Provisional; Region: hsdR; PRK11448 405955013931 Domain of unknown function (DUF4145); Region: DUF4145; pfam13643 405955013932 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; cl14958 405955013933 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 405955013934 ATP binding site [chemical binding]; other site 405955013935 putative Mg++ binding site [ion binding]; other site 405955013936 Restriction endonuclease [Defense mechanisms]; Region: Mrr; COG1715 405955013937 Mrr N-terminal domain; Region: Mrr_N; pfam14338 405955013938 Restriction endonuclease; Region: Mrr_cat; pfam04471 405955013939 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 405955013940 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 405955013941 P-loop, Walker A motif; other site 405955013942 Base recognition motif; other site 405955013943 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 405955013944 carbon starvation protein A; Provisional; Region: PRK15015 405955013945 Carbon starvation protein CstA; Region: CstA; pfam02554 405955013946 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 405955013947 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 405955013948 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 405955013949 dimer interface [polypeptide binding]; other site 405955013950 ligand binding site [chemical binding]; other site 405955013951 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405955013952 dimerization interface [polypeptide binding]; other site 405955013953 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 405955013954 dimer interface [polypeptide binding]; other site 405955013955 putative CheW interface [polypeptide binding]; other site 405955013956 DctM-like transporters; Region: DctM; pfam06808 405955013957 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 405955013958 Tripartite ATP-independent periplasmic transporters, DctQ component; Region: DctQ; pfam04290 405955013959 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 405955013960 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; cl15441 405955013961 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 405955013962 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 405955013963 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 405955013964 DNA-binding site [nucleotide binding]; DNA binding site 405955013965 Transcriptional regulators [Transcription]; Region: GntR; COG1802 405955013966 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 405955013967 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 405955013968 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 405955013969 putative NAD(P) binding site [chemical binding]; other site 405955013970 catalytic Zn binding site [ion binding]; other site 405955013971 structural Zn binding site [ion binding]; other site 405955013972 phosphoglycerol transferase I; Provisional; Region: PRK03776 405955013973 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 405955013974 hypothetical protein; Provisional; Region: PRK11667 405955013975 DNA replication protein DnaC; Validated; Region: PRK07952 405955013976 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955013977 Walker A motif; other site 405955013978 ATP binding site [chemical binding]; other site 405955013979 Walker B motif; other site 405955013980 primosomal protein DnaI; Provisional; Region: PRK02854 405955013981 hypothetical protein; Provisional; Region: PRK09917 405955013982 Uncharacterized conserved protein [Function unknown]; Region: COG2966 405955013983 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 405955013984 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 405955013985 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955013986 DNA binding residues [nucleotide binding] 405955013987 dimerization interface [polypeptide binding]; other site 405955013988 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 405955013989 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 405955013990 DNA binding residues [nucleotide binding] 405955013991 dimerization interface [polypeptide binding]; other site 405955013992 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 405955013993 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 405955013994 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 405955013995 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 405955013996 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 405955013997 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 405955013998 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955013999 S-adenosylmethionine binding site [chemical binding]; other site 405955014000 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 405955014001 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 405955014002 Coenzyme A binding pocket [chemical binding]; other site 405955014003 dUMP phosphatase; Provisional; Region: PRK09449 405955014004 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955014005 motif II; other site 405955014006 integrase; Provisional; Region: PRK09692 405955014007 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 405955014008 active site 405955014009 Int/Topo IB signature motif; other site 405955014010 Protein of unknown function (DUF551); Region: DUF551; pfam04448 405955014011 Ligand Binding Domain of Ephrin Receptors; Region: EphR_LBD; cl02704 405955014012 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 405955014013 Uncharacterized conserved protein [Function unknown]; Region: COG5532 405955014014 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 405955014015 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955014016 non-specific DNA binding site [nucleotide binding]; other site 405955014017 salt bridge; other site 405955014018 sequence-specific DNA binding site [nucleotide binding]; other site 405955014019 Predicted transcriptional regulator [Transcription]; Region: COG2932 405955014020 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 405955014021 Catalytic site [active] 405955014022 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955014023 non-specific DNA binding site [nucleotide binding]; other site 405955014024 salt bridge; other site 405955014025 sequence-specific DNA binding site [nucleotide binding]; other site 405955014026 Ash protein family; Region: Phage_ASH; pfam10554 405955014027 Phage regulatory protein Rha (Phage_pRha); Region: Phage_pRha; pfam09669 405955014028 Helix-turn-helix domain; Region: HTH_36; pfam13730 405955014029 PerC transcriptional activator; Region: PerC; pfam06069 405955014030 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 405955014031 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 405955014032 KilA-N domain; Region: KilA-N; pfam04383 405955014033 Protein of unknown function (DUF968); Region: DUF968; pfam06147 405955014034 Antitermination protein; Region: Antiterm; pfam03589 405955014035 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 405955014036 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 405955014037 Antitermination protein; Region: Antiterm; pfam03589 405955014038 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 405955014039 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 405955014040 catalytic residues [active] 405955014041 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 405955014042 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 405955014043 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 405955014044 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 405955014045 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 405955014046 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 405955014047 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 405955014048 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 405955014049 oligomer interface [polypeptide binding]; other site 405955014050 active site residues [active] 405955014051 Mu-like prophage major head subunit gpT; Region: Mu-like_gpT; cl01826 405955014052 Uncharacterized conserved protein [Function unknown]; Region: COG5471 405955014053 ATP-binding sugar transporter from pro-phage; Region: Gifsy-2; pfam13856 405955014054 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 405955014055 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 405955014056 Bacterial Ig-like domain 2; Region: BID_2; smart00635 405955014057 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; cl06106 405955014058 Minor tail protein T; Region: Phage_tail_T; pfam06223 405955014059 Phage-related minor tail protein [Function unknown]; Region: COG5281 405955014060 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 405955014061 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 405955014062 Phage-related protein [Function unknown]; Region: COG4718 405955014063 Phage-related protein [Function unknown]; Region: gp18; COG4672 405955014064 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 405955014065 MPN+ (JAMM) motif; other site 405955014066 Zinc-binding site [ion binding]; other site 405955014067 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 405955014068 NlpC/P60 family; Region: NLPC_P60; cl17555 405955014069 Phage-related protein, tail component [Function unknown]; Region: COG4723 405955014070 Phage-related protein, tail component [Function unknown]; Region: COG4733 405955014071 Putative phage tail protein; Region: Phage-tail_3; pfam13550 405955014072 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 405955014073 Fibronectin type III protein; Region: DUF3672; pfam12421 405955014074 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 405955014075 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 405955014076 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 405955014077 glyceraldehyde-3-phosphate dehydrogenase; Validated; Region: PRK07729 405955014078 multiple promoter invertase; Provisional; Region: mpi; PRK13413 405955014079 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405955014080 catalytic residues [active] 405955014081 catalytic nucleophile [active] 405955014082 Presynaptic Site I dimer interface [polypeptide binding]; other site 405955014083 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405955014084 Synaptic Flat tetramer interface [polypeptide binding]; other site 405955014085 Synaptic Site I dimer interface [polypeptide binding]; other site 405955014086 DNA binding site [nucleotide binding] 405955014087 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 405955014088 DNA-binding interface [nucleotide binding]; DNA binding site 405955014089 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 405955014090 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 405955014091 G1 box; other site 405955014092 putative GEF interaction site [polypeptide binding]; other site 405955014093 GTP/Mg2+ binding site [chemical binding]; other site 405955014094 Switch I region; other site 405955014095 G2 box; other site 405955014096 G3 box; other site 405955014097 Switch II region; other site 405955014098 G4 box; other site 405955014099 G5 box; other site 405955014100 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 405955014101 periplasmic protein; Provisional; Region: PRK10568 405955014102 BON domain; Region: BON; pfam04972 405955014103 BON domain; Region: BON; pfam04972 405955014104 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 405955014105 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 405955014106 active site 405955014107 nucleophile elbow; other site 405955014108 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 405955014109 active site 405955014110 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 405955014111 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 405955014112 FeS/SAM binding site; other site 405955014113 hypothetical protein; Provisional; Region: PRK10977 405955014114 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 405955014115 intersubunit interface [polypeptide binding]; other site 405955014116 active site 405955014117 catalytic residue [active] 405955014118 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 405955014119 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 405955014120 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 405955014121 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 405955014122 phosphopentomutase; Provisional; Region: PRK05362 405955014123 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 405955014124 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 405955014125 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 405955014126 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09775 405955014127 HipA-like N-terminal domain; Region: HipA_N; pfam07805 405955014128 HipA-like C-terminal domain; Region: HipA_C; pfam07804 405955014129 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 405955014130 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 405955014131 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 405955014132 hypothetical protein; Provisional; Region: PRK11246 405955014133 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 405955014134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955014135 motif II; other site 405955014136 DNA repair protein RadA; Region: sms; TIGR00416 405955014137 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 405955014138 Walker A motif/ATP binding site; other site 405955014139 ATP binding site [chemical binding]; other site 405955014140 Walker B motif; other site 405955014141 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 405955014142 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955014143 non-specific DNA binding site [nucleotide binding]; other site 405955014144 salt bridge; other site 405955014145 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 405955014146 sequence-specific DNA binding site [nucleotide binding]; other site 405955014147 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 405955014148 active site 405955014149 (T/H)XGH motif; other site 405955014150 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 405955014151 Protein of unknown function (DUF1044); Region: DUF1044; cl01955 405955014152 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955014153 non-specific DNA binding site [nucleotide binding]; other site 405955014154 salt bridge; other site 405955014155 sequence-specific DNA binding site [nucleotide binding]; other site 405955014156 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 405955014157 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955014158 Walker A/P-loop; other site 405955014159 ATP binding site [chemical binding]; other site 405955014160 Q-loop/lid; other site 405955014161 ABC transporter signature motif; other site 405955014162 Walker B; other site 405955014163 D-loop; other site 405955014164 H-loop/switch region; other site 405955014165 ABC transporter; Region: ABC_tran_2; pfam12848 405955014166 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 405955014167 lytic murein transglycosylase; Provisional; Region: PRK11619 405955014168 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405955014169 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405955014170 catalytic residue [active] 405955014171 Trp operon repressor; Provisional; Region: PRK01381 405955014172 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 405955014173 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 405955014174 catalytic core [active] 405955014175 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 405955014176 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 405955014177 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 405955014178 hypothetical protein; Provisional; Region: PRK10756 405955014179 CreA protein; Region: CreA; pfam05981 405955014180 DNA-binding response regulator CreB; Provisional; Region: PRK11083 405955014181 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955014182 active site 405955014183 phosphorylation site [posttranslational modification] 405955014184 intermolecular recognition site; other site 405955014185 dimerization interface [polypeptide binding]; other site 405955014186 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955014187 DNA binding site [nucleotide binding] 405955014188 sensory histidine kinase CreC; Provisional; Region: PRK11100 405955014189 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405955014190 dimerization interface [polypeptide binding]; other site 405955014191 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955014192 dimer interface [polypeptide binding]; other site 405955014193 phosphorylation site [posttranslational modification] 405955014194 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955014195 ATP binding site [chemical binding]; other site 405955014196 Mg2+ binding site [ion binding]; other site 405955014197 G-X-G motif; other site 405955014198 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 405955014199 two-component response regulator; Provisional; Region: PRK11173 405955014200 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955014201 active site 405955014202 phosphorylation site [posttranslational modification] 405955014203 intermolecular recognition site; other site 405955014204 dimerization interface [polypeptide binding]; other site 405955014205 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955014206 DNA binding site [nucleotide binding] 405955014207 putative RNA methyltransferase; Provisional; Region: PRK10433 405955014208 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 405955014209 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 405955014210 plasmid-partitioning protein SopA; Provisional; Region: PRK13705 405955014211 MerR family regulatory protein; Region: MerR; pfam00376 405955014212 DNA binding residues [nucleotide binding] 405955014213 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 405955014214 P-loop; other site 405955014215 Magnesium ion binding site [ion binding]; other site 405955014216 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 405955014217 Magnesium ion binding site [ion binding]; other site 405955014218 plasmid-partitioning protein; Provisional; Region: PRK13698 405955014219 ParB-like nuclease domain; Region: ParB; smart00470 405955014220 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405955014221 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 405955014222 Antirestriction protein; Region: Antirestrict; pfam03230 405955014223 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 405955014224 activation loop (A-loop); other site 405955014225 Domain of unknown function (DUF3560); Region: DUF3560; pfam12083 405955014226 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 405955014227 S-adenosylmethionine binding site [chemical binding]; other site 405955014228 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 405955014229 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 405955014230 dimer interface [polypeptide binding]; other site 405955014231 ssDNA binding site [nucleotide binding]; other site 405955014232 tetramer (dimer of dimers) interface [polypeptide binding]; other site 405955014233 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 405955014234 ParB-like nuclease domain; Region: ParBc; pfam02195 405955014235 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 405955014236 plasmid SOS inhibition protein B; Provisional; Region: psiB; PRK13701 405955014237 plasmid SOS inhibition protein A; Provisional; Region: PRK13704 405955014238 modulator of post-segregation killing protein; Provisional; Region: PRK13720 405955014239 Domain of unknown function (DUF932); Region: DUF932; pfam06067 405955014240 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 405955014241 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405955014242 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405955014243 catalytic residue [active] 405955014244 TraM protein; Region: Tra_M; pfam05261 405955014245 conjugal transfer transcriptional regulator TraJ; Provisional; Region: PRK13719 405955014246 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cl17315 405955014247 conjugal transfer protein TraY; Provisional; Region: PRK13740 405955014248 conjugal transfer protein TraY; Provisional; Region: PRK13740 405955014249 conjugal transfer pilin subunit TraA; Provisional; Region: PRK13734 405955014250 conjugal transfer pilus assembly protein TraL; Provisional; Region: PRK13707 405955014251 conjugal transfer pilus assembly protein TraE; Provisional; Region: PRK13726 405955014252 conjugal transfer protein TraK; Provisional; Region: PRK13736 405955014253 TraK protein; Region: TraK; pfam06586 405955014254 conjugal transfer pilus assembly protein TraB; Provisional; Region: PRK13729 405955014255 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 405955014256 conjugal transfer protein TraP; Provisional; Region: PRK13739 405955014257 conjugal transfer protein TrbD; Provisional; Region: PRK13724 405955014258 conjugal transfer protein TrbG; Provisional; Region: PRK13744 405955014259 conjugal transfer protein TraV; Provisional; Region: PRK13733 405955014260 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 405955014261 conjugal transfer protein TraR; Provisional; Region: PRK13715 405955014262 conjugal transfer ATP-binding protein TraC; Provisional; Region: PRK13721 405955014263 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 405955014264 conjugal transfer protein TrbI; Provisional; Region: PRK13717 405955014265 conjugal transfer pilus assembly protein TraW; Provisional; Region: PRK13738 405955014266 conjugal transfer pilus assembly protein TraU; Provisional; Region: PRK13737 405955014267 conjugal transfer pilus assembly protein TrbC; Provisional; Region: PRK13730 405955014268 conjugal transfer mating pair stabilization protein TraN; Reviewed; Region: PRK12355 405955014269 conjugal transfer protein TrbE; Provisional; Region: PRK13718 405955014270 conjugal pilus assembly protein TraF; Provisional; Region: PRK13703 405955014271 F plasmid transfer operon protein; Region: TraF; pfam13728 405955014272 conjugal transfer protein TrbA; Provisional; Region: PRK13712 405955014273 conjugal transfer pilin chaperone TraQ; Provisional; Region: PRK13727 405955014274 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 405955014275 catalytic residues [active] 405955014276 conjugal transfer protein TrbJ; Provisional; Region: PRK13711 405955014277 conjugal transfer pilus assembly protein TraH; Provisional; Region: PRK13723 405955014278 conjugal transfer mating pair stabilization protein TraG; Provisional; Region: PRK13735 405955014279 conjugal transfer entry exclusion protein TraS; Provisional; Region: PRK13741 405955014280 conjugal transfer surface exclusion protein TraT; Provisional; Region: PRK13731 405955014281 Enterobacterial TraT complement resistance protein; Region: TraT; pfam05818 405955014282 conjugal transfer protein TraD; Provisional; Region: PRK13700 405955014283 F sex factor protein N terminal; Region: TraD_N; pfam12615 405955014284 Bacterial conjugation protein TrwB, ATP binding domain. TrwB is a homohexamer encoded by conjugative plasmids in Gram-negative bacteria. TrwB also has an all alpha domain which has been hypothesized to be responsible for DNA binding. TrwB is a component...; Region: TrwB; cd01127 405955014285 multimer interface [polypeptide binding]; other site 405955014286 Walker A motif; other site 405955014287 ATP binding site [chemical binding]; other site 405955014288 Walker B motif; other site 405955014289 conjugal transfer nickase/helicase TraI; Provisional; Region: PRK13709 405955014290 conjugative relaxase domain, TrwC/TraI family; Region: relax_trwC; TIGR02686 405955014291 AAA domain; Region: AAA_30; pfam13604 405955014292 DNA helicase TraI; Region: TraI; pfam07057 405955014293 conjugal transfer pilus acetylation protein TraX; Provisional; Region: PRK13706 405955014294 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 405955014295 conjugal transfer fertility inhibition protein FinO; Provisional; Region: PRK13754 405955014296 Fertility inhibition protein N terminal; Region: FinO_N; pfam12602 405955014297 FinO bacterial conjugation repressor domain; the basic protein FinO is part of the the two component FinOP system which is responsible for repressing bacterial conjugation; the FinOP system represses the transfer (tra) operon of the F-plasmid which...; Region: FinO_conjug_rep; cd00236 405955014298 putative RNA binding sites [nucleotide binding]; other site 405955014299 Hok/gef family; Region: HOK_GEF; pfam01848 405955014300 RepFIIA replicon 405955014301 replication protein; Provisional; Region: PRK13702 405955014302 IncFII RepA protein family; Region: IncFII_repA; cl11495 405955014303 replication protein; Provisional; Region: PRK13750 405955014304 Antitoxin of toxin-antitoxin stability system [Cell division and chromosome partitioning]; Region: StbD; COG2161 405955014305 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 405955014306 putative transposase OrfB; Reviewed; Region: PHA02517 405955014307 HTH-like domain; Region: HTH_21; pfam13276 405955014308 Integrase core domain; Region: rve; pfam00665 405955014309 Integrase core domain; Region: rve_3; pfam13683 405955014310 Transposase; Region: HTH_Tnp_1; cl17663 405955014311 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405955014312 Immunoglobulin A1 protease; Region: Peptidase_S6; pfam02395 405955014313 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 405955014314 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 405955014315 Autotransporter beta-domain; Region: Autotransporter; pfam03797 405955014316 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 405955014317 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 405955014318 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 405955014319 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955014320 Walker A motif; other site 405955014321 ATP binding site [chemical binding]; other site 405955014322 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 405955014323 RNA polymerase sigma factor, sigma-70 family; Region: sigma70-ECF; TIGR02937 405955014324 DNA binding residues [nucleotide binding] 405955014325 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 405955014326 Integrase core domain; Region: rve; pfam00665 405955014327 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 405955014328 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955014329 AAA domain; Region: AAA_21; pfam13304 405955014330 Walker A/P-loop; other site 405955014331 ATP binding site [chemical binding]; other site 405955014332 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 405955014333 putative active site [active] 405955014334 putative metal-binding site [ion binding]; other site 405955014335 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 405955014336 putative trimer interface [polypeptide binding]; other site 405955014337 WcxM-like, Left-handed parallel beta-Helix (LbH) N-terminal domain: This group is composed of Xanthomonas campestris WcxM and proteins with similarity to the WcxM N-terminal domain. WcxM is thought to be bifunctional, catalyzing both the isomerization...; Region: LbH_WxcM_N_like; cd03358 405955014338 putative CoA binding site [chemical binding]; other site 405955014339 putative trimer interface [polypeptide binding]; other site 405955014340 putative active site [active] 405955014341 putative substrate binding site [chemical binding]; other site 405955014342 putative CoA binding site [chemical binding]; other site 405955014343 Flavin-binding monooxygenase-like; Region: FMO-like; pfam00743 405955014344 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405955014345 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 405955014346 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 405955014347 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 405955014348 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 405955014349 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 405955014350 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 405955014351 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 405955014352 inhibitor-cofactor binding pocket; inhibition site 405955014353 pyridoxal 5'-phosphate binding site [chemical binding]; other site 405955014354 catalytic residue [active] 405955014355 Phage terminase small subunit; Region: Phage_terminase; pfam10668 405955014356 Transposase; Region: HTH_Tnp_1; pfam01527 405955014357 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405955014358 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 405955014359 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 405955014360 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 405955014361 homodimer interface [polypeptide binding]; other site 405955014362 putative GKAP docking site [polypeptide binding]; other site 405955014363 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 405955014364 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 405955014365 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 405955014366 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 405955014367 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 405955014368 Transposase; Region: HTH_Tnp_1; cl17663 405955014369 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405955014370 IS2 transposase TnpB; Reviewed; Region: PRK09409 405955014371 HTH-like domain; Region: HTH_21; pfam13276 405955014372 Integrase core domain; Region: rve; pfam00665 405955014373 Integrase core domain; Region: rve_3; pfam13683 405955014374 Autotransporter-associated beta strand repeat; Region: Autotrns_rpt; pfam12951 405955014375 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 405955014376 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 405955014377 Autotransporter beta-domain; Region: Autotransporter; pfam03797 405955014378 Transposase; Region: HTH_Tnp_1; cl17663 405955014379 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405955014380 putative transposase OrfB; Reviewed; Region: PHA02517 405955014381 HTH-like domain; Region: HTH_21; pfam13276 405955014382 Integrase core domain; Region: rve; pfam00665 405955014383 Integrase core domain; Region: rve_3; pfam13683 405955014384 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955014385 ABC-type cobalamin/Fe3+-siderophores transport systems, ATPase components [Inorganic ion transport and metabolism / Coenzyme metabolism]; Region: FepC; COG1120 405955014386 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 405955014387 Walker A/P-loop; other site 405955014388 ATP binding site [chemical binding]; other site 405955014389 Q-loop/lid; other site 405955014390 ABC transporter signature motif; other site 405955014391 Walker B; other site 405955014392 D-loop; other site 405955014393 H-loop/switch region; other site 405955014394 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 405955014395 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955014396 ABC-ATPase subunit interface; other site 405955014397 dimer interface [polypeptide binding]; other site 405955014398 putative PBP binding regions; other site 405955014399 Helical backbone metal receptor (TroA-like domain). These proteins have been shown to function in the ABC transport of ferric siderophores and metal ions such as Mn2+, Fe3+, Cu2+ and/or Zn2+. Their ligand binding site is formed in the interface between...; Region: TroA-like; cl00262 405955014400 proposed F420-0 ABC transporter, periplasmic F420-0 binding protein; Region: F420-O_ABCperi; TIGR03868 405955014401 intersubunit interface [polypeptide binding]; other site 405955014402 multiple promoter invertase; Provisional; Region: mpi; PRK13413 405955014403 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405955014404 catalytic residues [active] 405955014405 catalytic nucleophile [active] 405955014406 Presynaptic Site I dimer interface [polypeptide binding]; other site 405955014407 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405955014408 Synaptic Flat tetramer interface [polypeptide binding]; other site 405955014409 Synaptic Site I dimer interface [polypeptide binding]; other site 405955014410 DNA binding site [nucleotide binding] 405955014411 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 405955014412 DNA-binding interface [nucleotide binding]; DNA binding site 405955014413 Predicted transcriptional regulator [Transcription]; Region: COG3905 405955014414 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 405955014415 Putative transposase; Region: Y2_Tnp; pfam04986 405955014416 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955014417 Walker B; other site 405955014418 D-loop; other site 405955014419 H-loop/switch region; other site 405955014420 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 405955014421 oligomeric interface; other site 405955014422 putative active site [active] 405955014423 homodimer interface [polypeptide binding]; other site 405955014424 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 405955014425 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405955014426 active site 405955014427 catalytic residues [active] 405955014428 DNA binding site [nucleotide binding] 405955014429 Int/Topo IB signature motif; other site 405955014430 YebF-like protein; Region: YebF; cl10126 405955014431 Colicin immunity protein; Region: Colicin_im; pfam03857 405955014432 A sub-family of peptidase family C39. Peptidase family C39 mostly contains bacteriocin-processing endopeptidases from bacteria. The cysteine peptidases in family C39 cleave the "double-glycine" leader peptides from the precursors of various...; Region: Peptidase_C39C; cd02419 405955014433 putative active site [active] 405955014434 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405955014435 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 405955014436 HlyD family secretion protein; Region: HlyD; pfam00529 405955014437 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955014438 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955014439 IS2 transposase TnpB; Reviewed; Region: PRK09409 405955014440 HTH-like domain; Region: HTH_21; pfam13276 405955014441 Integrase core domain; Region: rve; pfam00665 405955014442 Integrase core domain; Region: rve_3; pfam13683 405955014443 IS2 repressor TnpA; Reviewed; Region: PRK09413 405955014444 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405955014445 Predicted transcriptional regulator [Transcription]; Region: COG3905 405955014446 Plasmid stabilisation system protein; Region: Plasmid_stabil; pfam05016 405955014447 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 405955014448 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 405955014449 active site 405955014450 catalytic site [active] 405955014451 substrate binding site [chemical binding]; other site 405955014452 Lipase (class 2); Region: Lipase_2; pfam01674 405955014453 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthase [Amino acid transport and metabolism]; Region: AroG; cl17260 405955014454 Salmochelin siderophore iron acquisition system 405955014455 outer membrane receptor FepA; Provisional; Region: PRK13528 405955014456 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 405955014457 N-terminal plug; other site 405955014458 ligand-binding site [chemical binding]; other site 405955014459 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405955014460 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 405955014461 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 405955014462 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 405955014463 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405955014464 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405955014465 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955014466 Walker A/P-loop; other site 405955014467 ATP binding site [chemical binding]; other site 405955014468 Q-loop/lid; other site 405955014469 ABC transporter signature motif; other site 405955014470 Walker B; other site 405955014471 D-loop; other site 405955014472 H-loop/switch region; other site 405955014473 ABC-type multidrug transport system, ATPase and permease components [Defense mechanisms]; Region: MdlB; COG1132 405955014474 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 405955014475 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955014476 Walker A/P-loop; other site 405955014477 ATP binding site [chemical binding]; other site 405955014478 Q-loop/lid; other site 405955014479 ABC transporter signature motif; other site 405955014480 Walker B; other site 405955014481 D-loop; other site 405955014482 H-loop/switch region; other site 405955014483 Glycosyl transferases, related to UDP-glucuronosyltransferase [Carbohydrate transport and metabolism / Signal transduction mechanisms]; Region: COG1819 405955014484 This family includes the Gtfs, a group of homologous glycosyltransferases involved in the final stages of the biosynthesis of antibiotics vancomycin and related chloroeremomycin. Gtfs transfer sugar moieties from an activated NDP-sugar donor to the...; Region: GT1_Gtf_like; cd03784 405955014485 homodimer interface [polypeptide binding]; other site 405955014486 active site 405955014487 TDP-binding site; other site 405955014488 acceptor substrate-binding pocket; other site 405955014489 Integrase core domain; Region: rve; pfam00665 405955014490 Integrase core domain; Region: rve_3; pfam13683 405955014491 Helix-turn-helix domain; Region: HTH_28; pfam13518 405955014492 Bor protein; Region: Lambda_Bor; pfam06291 405955014493 IS2 repressor TnpA; Reviewed; Region: PRK09413 405955014494 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405955014495 IS2 transposase TnpB; Reviewed; Region: PRK09409 405955014496 HTH-like domain; Region: HTH_21; pfam13276 405955014497 Integrase core domain; Region: rve; pfam00665 405955014498 Integrase core domain; Region: rve_3; pfam13683 405955014499 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 405955014500 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405955014501 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 405955014502 Integrase core domain; Region: rve; pfam00665 405955014503 Winged helix-turn helix; Region: HTH_29; pfam13551 405955014504 Helix-turn-helix domain; Region: HTH_28; pfam13518 405955014505 Homeodomain-like domain; Region: HTH_32; pfam13565 405955014506 Integrase core domain; Region: rve; pfam00665 405955014507 Abortive infection C-terminus; Region: Abi_C; pfam14355 405955014508 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 405955014509 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 405955014510 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 405955014511 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 405955014512 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 405955014513 Protein of unknown function, DUF270; Region: Otopetrin; pfam03189 405955014514 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 405955014515 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 405955014516 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 405955014517 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 405955014518 TonB-dependent siderophore receptor; Region: TonB-siderophor; TIGR01783 405955014519 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 405955014520 N-terminal plug; other site 405955014521 ligand-binding site [chemical binding]; other site 405955014522 Lysine/ornithine N-monooxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: IucD; COG3486 405955014523 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 405955014524 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 405955014525 IucA / IucC family; Region: IucA_IucC; pfam04183 405955014526 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 405955014527 Acetyltransferase (GNAT) domain; Region: Acetyltransf_8; pfam13523 405955014528 Siderophore biosynthesis protein domain; Region: AlcB; smart01006 405955014529 Siderophore synthetase component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: RhbC; COG4264 405955014530 IucA / IucC family; Region: IucA_IucC; pfam04183 405955014531 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 405955014532 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955014533 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405955014534 putative substrate translocation pore; other site 405955014535 chromosome condensation membrane protein; Provisional; Region: PRK14196 405955014536 Telomerase activating protein Est1; Region: EST1; pfam10374 405955014537 Enolase-superfamily, characterized by the presence of an enolate anion intermediate which is generated by abstraction of the alpha-proton of the carboxylate substrate by an active site residue and is stabilized by coordination to the essential Mg2+ ion; Region: enolase_like; cl17188 405955014538 substrate binding pocket [chemical binding]; other site 405955014539 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 405955014540 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955014541 ABC-ATPase subunit interface; other site 405955014542 dimer interface [polypeptide binding]; other site 405955014543 putative PBP binding regions; other site 405955014544 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 405955014545 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 405955014546 ABC-ATPase subunit interface; other site 405955014547 dimer interface [polypeptide binding]; other site 405955014548 putative PBP binding regions; other site 405955014549 manganese/iron transporter ATP-binding protein; Provisional; Region: PRK15056 405955014550 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 405955014551 ABC-type metal ion transport system, periplasmic component/surface adhesin [Inorganic ion transport and metabolism]; Region: LraI; COG0803 405955014552 Metal binding protein PsaA. These proteins have been shown to function as initial receptors in ABC transport of Mn2+ and as surface adhesins in some eubacterial species. They belong to the TroA superfamily of periplasmic metal binding proteins that...; Region: PsaA; cd01137 405955014553 metal binding site [ion binding]; metal-binding site 405955014554 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 405955014555 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 405955014556 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 405955014557 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 405955014558 Y-family of DNA polymerases; Region: PolY; cl12025 405955014559 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 405955014560 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG4584 405955014561 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cl17393 405955014562 Transposase family tnp2; Region: Transposase_21; pfam02992 405955014563 Initiator Replication protein; Region: Rep_3; cl03080 405955014564 DNA breaking-rejoining enzymes, intergrase/recombinases, C-terminal catalytic domain. The tyrosine recombinase/integrase family share the same catalytic domain containing six conserved active site residues. The best-studied members of this diverse family...; Region: INT_REC_C; cd01182 405955014565 active site 405955014566 catalytic residues [active] 405955014567 DNA binding site [nucleotide binding] 405955014568 Int/Topo IB signature motif; other site 405955014569 antimicrobial resistance protein Mig-14; Provisional; Region: PRK15312 405955014570 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 405955014571 NAD(P) binding site [chemical binding]; other site 405955014572 active site 405955014573 Transposase; Region: HTH_Tnp_1; cl17663 405955014574 putative transposase OrfB; Reviewed; Region: PHA02517 405955014575 HTH-like domain; Region: HTH_21; pfam13276 405955014576 Integrase core domain; Region: rve; pfam00665 405955014577 Integrase core domain; Region: rve_3; pfam13683 405955014578 Integrase core domain; Region: rve; pfam00665 405955014579 RND family efflux transporter, MFP subunit; Region: RND_mfp; TIGR01730 405955014580 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 405955014581 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955014582 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 405955014583 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 405955014584 Walker A/P-loop; other site 405955014585 ATP binding site [chemical binding]; other site 405955014586 Q-loop/lid; other site 405955014587 ABC transporter signature motif; other site 405955014588 Walker B; other site 405955014589 D-loop; other site 405955014590 H-loop/switch region; other site 405955014591 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 405955014592 FtsX-like permease family; Region: FtsX; pfam02687 405955014593 efflux transporter, outer membrane factor (OMF) lipoprotein, NodT family; Region: outer_NodT; TIGR01845 405955014594 TrfA protein; Region: TrfA; pfam07042 405955014595 TraL protein; Region: TraL; cl06278 405955014596 TraE protein; Region: TraE; cl05060 405955014597 TraK protein; Region: TraK; pfam06586 405955014598 Bacterial conjugation TrbI-like protein; Region: TrbI; pfam03743 405955014599 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 405955014600 dimerization domain [polypeptide binding]; other site 405955014601 dimer interface [polypeptide binding]; other site 405955014602 catalytic residues [active] 405955014603 Type IV conjugative transfer system lipoprotein (TraV); Region: TraV; pfam09676 405955014604 F pilus assembly Type-IV secretion system for plasmid transfer; Region: TraC_F_IV; pfam11130 405955014605 type-IV secretion system protein TraC; Region: TraC-F-type; TIGR02746 405955014606 ATPases involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: Soj; COG1192 405955014607 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 405955014608 ParA and ParB of Caulobacter crescentus belong to a conserved family of bacterial proteins implicated in chromosome segregation. ParB binds to DNA sequences adjacent to the origin of replication and localizes to opposite cell poles shortly following the...; Region: ParA; cd02042 405955014609 Magnesium ion binding site [ion binding]; other site 405955014610 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 405955014611 ParB-like nuclease domain; Region: ParB; smart00470 405955014612 ParB family; Region: ParB; pfam08775 405955014613 metallophosphatase superfamily, metallophosphatase domain; Region: MPP_superfamily; cl13995 405955014614 active site 405955014615 metal binding site [ion binding]; metal-binding site 405955014616 Plasmid segregation protein ParM and similar proteins; Region: ParM_like; cd10227 405955014617 Mg binding site [ion binding]; other site 405955014618 nucleotide binding site [chemical binding]; other site 405955014619 putative protofilament interface [polypeptide binding]; other site 405955014620 Transposase domain (DUF772); Region: DUF772; pfam05598 405955014621 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 405955014622 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 405955014623 signal peptidase I, bacterial type; Region: sigpep_I_bact; TIGR02227 405955014624 Type-F conjugative transfer system pilin assembly protein; Region: TrbC_Ftype; pfam09673 405955014625 Sex factor F TraW protein N terminal; Region: TraW_N; cl10149 405955014626 TraU protein; Region: TraU; pfam06834 405955014627 conjugal transfer mating pair stabilization protein TraN; Provisional; Region: PRK14877 405955014628 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 405955014629 Part of AAA domain; Region: AAA_19; pfam13245 405955014630 Family description; Region: UvrD_C_2; pfam13538 405955014631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 405955014632 Walker A motif; other site 405955014633 ATP binding site [chemical binding]; other site 405955014634 Walker B motif; other site 405955014635 Protein of unknown function (DUF3150); Region: DUF3150; pfam11348 405955014636 Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of...; Region: vWFA; cl00057 405955014637 metal ion-dependent adhesion site (MIDAS); other site 405955014638 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 405955014639 Toprim domain; Region: Toprim_3; pfam13362 405955014640 active site 405955014641 metal binding site [ion binding]; metal-binding site 405955014642 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 405955014643 Gammaherpesvirus latent membrane protein (LMP2) protein; Region: Herpes_LMP2; pfam07415 405955014644 DNA replication terminus site-binding protein (Ter protein); Region: Ter; pfam05472 405955014645 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 405955014646 active site 405955014647 DNA binding site [nucleotide binding] 405955014648 Int/Topo IB signature motif; other site 405955014649 Competence protein CoiA-like family; Region: CoiA; cl11541 405955014650 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 405955014651 substrate binding site [chemical binding]; other site 405955014652 activation loop (A-loop); other site 405955014653 Protein phosphatase 2C; Region: PP2C_2; pfam13672 405955014654 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 405955014655 metal ion-dependent adhesion site (MIDAS); other site 405955014656 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 405955014657 metal ion-dependent adhesion site (MIDAS); other site 405955014658 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405955014659 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405955014660 putative metal binding site [ion binding]; other site 405955014661 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 405955014662 metal ion-dependent adhesion site (MIDAS); other site 405955014663 Predicted transcriptional regulator [Transcription]; Region: COG2378 405955014664 Protein of unknown function (DUF4236); Region: DUF4236; pfam14020 405955014665 Citrate lyase beta subunit [Carbohydrate transport and metabolism]; Region: CitE; COG2301 405955014666 Protein of unknown function (DUF2983); Region: DUF2983; pfam11202 405955014667 HAD-superfamily hydrolase, subfamily IIB; Region: HAD-SF-IIB; TIGR01484 405955014668 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 405955014669 active site 405955014670 Protein of unknown function (DUF3706); Region: DUF3706; pfam12500 405955014671 carbamoyl phosphate synthase-like protein; Provisional; Region: PRK12767 405955014672 ATP-grasp domain; Region: ATP-grasp_4; pfam13535 405955014673 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405955014674 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405955014675 putative metal binding site [ion binding]; other site 405955014676 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405955014677 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405955014678 putative metal binding site [ion binding]; other site 405955014679 Uncharacterized protein involved in stress response [General function prediction only]; Region: COG4110 405955014680 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405955014681 putative metal binding site [ion binding]; other site 405955014682 tellurite resistance protein terB; Region: terB; cd07176 405955014683 putative metal binding site [ion binding]; other site 405955014684 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 405955014685 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405955014686 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405955014687 putative metal binding site [ion binding]; other site 405955014688 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405955014689 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405955014690 putative metal binding site [ion binding]; other site 405955014691 Uncharacterized proteins involved in stress response, homologs of TerZ and putative cAMP-binding protein CABP1 [Signal transduction mechanisms]; Region: TerZ; COG2310 405955014692 Uncharacterized proteins involved in stress response, similar to tellurium resistance terD; Region: TerD_like; cd06974 405955014693 putative metal binding site [ion binding]; other site 405955014694 Bacterial stress protein; Region: TerD; pfam02342 405955014695 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955014696 salt bridge; other site 405955014697 non-specific DNA binding site [nucleotide binding]; other site 405955014698 sequence-specific DNA binding site [nucleotide binding]; other site 405955014699 HipA N-terminal domain; Region: couple_hipA; TIGR03071 405955014700 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 405955014701 HipA-like N-terminal domain; Region: HipA_N; pfam07805 405955014702 HipA-like C-terminal domain; Region: HipA_C; pfam07804 405955014703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 405955014704 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 405955014705 Integrase core domain; Region: rve; pfam00665 405955014706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955014707 Major Facilitator Superfamily; Region: MFS_1; pfam07690 405955014708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 405955014709 tetracycline repressor protein TetR; Provisional; Region: PRK13756 405955014710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 405955014711 Tetracyclin repressor, C-terminal all-alpha domain; Region: TetR_C; pfam02909 405955014712 Domain of unknown function (DUF4158); Region: DUF4158; pfam13700 405955014713 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; pfam01526 405955014714 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 405955014715 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 405955014716 Presynaptic Site I dimer interface [polypeptide binding]; other site 405955014717 catalytic residues [active] 405955014718 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 405955014719 Synaptic Flat tetramer interface [polypeptide binding]; other site 405955014720 Synaptic Site I dimer interface [polypeptide binding]; other site 405955014721 DNA binding site [nucleotide binding] 405955014722 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 405955014723 DNA-binding interface [nucleotide binding]; DNA binding site 405955014724 5' conserved segment of In4-like class 1 integron 405955014725 integrase/recombinase; Provisional; Region: PRK15417 405955014726 IntI (E2) integrases, site-specific tyrosine recombinases, DNA breaking-rejoining enzymes, N- and C-terminal domains. This CD includes integrases which are components of multiresistant integrons and mediate recombination between a proximal attI site and...; Region: INT_IntI; cd01193 405955014727 Int/Topo IB signature motif; other site 405955014728 attI1 site; recombination crossover region 405955014729 aminoglycoside resistance protein; Provisional; Region: PRK13746 405955014730 Nucleotidyltransferase (NT) domain of Staphylococcus aureus kanamycin nucleotidyltransferase, and similar proteins; Region: NT_KNTase_like; cd05403 405955014731 active site 405955014732 NTP binding site [chemical binding]; other site 405955014733 metal binding triad [ion binding]; metal-binding site 405955014734 antibiotic binding site [chemical binding]; other site 405955014735 Domain of unknown function (DUF4111); Region: DUF4111; pfam13427 405955014736 3' portion of 59-bp element 405955014737 Aminoglycoside 3-N-acetyltransferase; Region: Antibiotic_NAT; pfam02522 405955014738 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 405955014739 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 405955014740 ring oligomerisation interface [polypeptide binding]; other site 405955014741 ATP/Mg binding site [chemical binding]; other site 405955014742 stacking interactions; other site 405955014743 hinge regions; other site 405955014744 Transposase zinc-binding domain; Region: Zn_Tnp_IS91; pfam14319 405955014745 Putative transposase; Region: Y2_Tnp; pfam04986 405955014746 3' conserved segment of In4-like class 1 integron 405955014747 Small Multidrug Resistance protein; Region: Multi_Drug_Res; pfam00893 405955014748 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 405955014749 dihydropteroate synthase; Region: DHPS; TIGR01496 405955014750 substrate binding pocket [chemical binding]; other site 405955014751 dimer interface [polypeptide binding]; other site 405955014752 inhibitor binding site; inhibition site 405955014753 Tn3 transposase DDE domain; Region: DDE_Tnp_Tn3; cl14901 405955014754 TnsA endonuclease N terminal; Region: Tn7_Tnp_TnsA_N; pfam08722 405955014755 TnsA endonuclease C terminal; Region: Tn7_Tnp_TnsA_C; pfam08721 405955014756 AAA ATPase domain; Region: AAA_16; pfam13191 405955014757 AAA domain; Region: AAA_22; pfam13401 405955014758 TniQ; Region: TniQ; pfam06527 405955014759 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 405955014760 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405955014761 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 405955014762 salt bridge; other site 405955014763 non-specific DNA binding site [nucleotide binding]; other site 405955014764 sequence-specific DNA binding site [nucleotide binding]; other site 405955014765 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 405955014766 Walker A/P-loop; other site 405955014767 ATP binding site [chemical binding]; other site 405955014768 AAA ATPase domain; Region: AAA_15; pfam13175 405955014769 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 405955014770 active site 405955014771 metal binding site [ion binding]; metal-binding site 405955014772 sensor kinase CusS; Provisional; Region: PRK09835 405955014773 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405955014774 dimerization interface [polypeptide binding]; other site 405955014775 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955014776 dimer interface [polypeptide binding]; other site 405955014777 phosphorylation site [posttranslational modification] 405955014778 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955014779 ATP binding site [chemical binding]; other site 405955014780 Mg2+ binding site [ion binding]; other site 405955014781 G-X-G motif; other site 405955014782 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 405955014783 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955014784 active site 405955014785 phosphorylation site [posttranslational modification] 405955014786 intermolecular recognition site; other site 405955014787 dimerization interface [polypeptide binding]; other site 405955014788 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955014789 DNA binding site [nucleotide binding] 405955014790 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 405955014791 periplasmic copper-binding protein; Provisional; Region: PRK09838 405955014792 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 405955014793 HlyD family secretion protein; Region: HlyD_3; pfam13437 405955014794 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 405955014795 Protein of unknown function, DUF; Region: DUF411; cl01142 405955014796 YHS domain; Region: YHS; pfam04945 405955014797 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 405955014798 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 405955014799 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 405955014800 motif II; other site 405955014801 Peptidase family M23; Region: Peptidase_M23; pfam01551 405955014802 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 405955014803 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 405955014804 Multicopper oxidase; Region: Cu-oxidase; pfam00394 405955014805 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 405955014806 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 405955014807 CopC domain; Region: CopC; pfam04234 405955014808 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 405955014809 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 405955014810 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 405955014811 active site 405955014812 phosphorylation site [posttranslational modification] 405955014813 intermolecular recognition site; other site 405955014814 dimerization interface [polypeptide binding]; other site 405955014815 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 405955014816 DNA binding site [nucleotide binding] 405955014817 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 405955014818 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 405955014819 dimerization interface [polypeptide binding]; other site 405955014820 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 405955014821 dimer interface [polypeptide binding]; other site 405955014822 phosphorylation site [posttranslational modification] 405955014823 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 405955014824 ATP binding site [chemical binding]; other site 405955014825 Mg2+ binding site [ion binding]; other site 405955014826 G-X-G motif; other site 405955014827 Methyltransferase domain; Region: Methyltransf_27; pfam13708 405955014828 Chromosome segregation ATPases [Cell division and chromosome partitioning]; Region: Smc; COG1196 405955014829 Protein of unknown function (DUF1173); Region: DUF1173; pfam06666 405955014830 DNA cytosine methylase; Provisional; Region: PRK10458 405955014831 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 405955014832 cofactor binding site; other site 405955014833 DNA binding site [nucleotide binding] 405955014834 substrate interaction site [chemical binding]; other site 405955014835 Staphylococcal nuclease homologues; Region: SNc; smart00318 405955014836 Staphylococcal nuclease homologues. SNase homologues are found in bacteria, archaea, and eukaryotes. They contain no disufide bonds; Region: SNc; cd00175 405955014837 Catalytic site; other site 405955014838 Protein of unknown function (DUF2726); Region: DUF2726; pfam10881 405955014839 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3316 405955014840 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 405955014841 Integrase core domain; Region: rve; pfam00665 405955014842 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 405955014843 Catalytic site [active] 405955014844 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 405955014845 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 405955014846 active site 405955014847 DNA binding site [nucleotide binding] 405955014848 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 405955014849 DsbA family, Com1-like subfamily; composed of proteins similar to Com1, a 27-kDa outer membrane-associated immunoreactive protein originally found in both acute and chronic disease strains of the pathogenic bacteria Coxiella burnetti. It contains a CXXC...; Region: DsbA_Com1_like; cd03023 405955014850 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 405955014851 catalytic residues [active] 405955014852 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 405955014853 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 405955014854 dimerization domain [polypeptide binding]; other site 405955014855 dimer interface [polypeptide binding]; other site 405955014856 catalytic residues [active] 405955014857 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 405955014858 N-acetyl-D-glucosamine binding site [chemical binding]; other site 405955014859 HNH endonuclease; Region: HNH_2; pfam13391 405955014860 TraG-like protein, N-terminal region; Region: TraG_N; pfam07916 405955014861 Conjugative relaxosome accessory transposon protein; Region: TraH; pfam06122 405955014862 TraF-like protein; Region: TraF-like; TIGR02740 405955014863 F plasmid transfer operon protein; Region: TraF; pfam13728 405955014864 Putative helicase; Region: TraI_2; pfam07514 405955014865 integrating conjugative element relaxase, PFL_4751 family; Region: ICE_TraI_Pfluor; TIGR03760 405955014866 conjugative coupling factor TraD, SXT/TOL subfamily; Region: SXT_TraD; TIGR03743 405955014867 TraM recognition site of TraD and TraG; Region: TraG-D_C; cl17375 405955014868 Domain of unknown function (DUF4400); Region: DUF4400; pfam14348 405955014869 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 405955014870 tandem repeat interface [polypeptide binding]; other site 405955014871 oligomer interface [polypeptide binding]; other site 405955014872 Periplasmic serine proteases (ClpP class) [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: SppA; COG0616 405955014873 active site residues [active] 405955014874 Nuclease-related domain; Region: NERD; pfam08378 405955014875 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 405955014876 small toxic polypeptide; Provisional; Region: PRK09738 405955014877 Protein of unknown function (DUF3085); Region: DUF3085; pfam11284 405955014878 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 405955014879 pyruvate oxidase; Provisional; Region: PRK08611 405955014880 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 405955014881 active site 405955014882 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 405955014883 Active Sites [active] 405955014884 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 405955014885 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405955014886 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 405955014887 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 405955014888 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 405955014889 Domain of unknown function (DUF4165); Region: DUF4165; pfam13752 405955014890 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 405955014891 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 405955014892 Methyltransferase domain; Region: Methyltransf_26; pfam13659 405955014893 Domain of unknown function (DUF4165); Region: DUF4165; pfam13752 405955014894 Bacterial Ig-like domain (group 3); Region: Big_3_2; pfam12245 405955014895 Bacterial Ig-like domain (group 3); Region: Big_3_4; pfam13754 405955014896 Bacterial Ig-like domain (group 3); Region: Big_3_3; pfam13750 405955014897 Plasmid maintenance system killer protein; Region: Plasmid_killer; cl01422 405955014898 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cl00352 405955014899 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 405955014900 Mrr N-terminal domain; Region: Mrr_N; pfam14338 405955014901 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 405955014902 DNA methylase; Region: N6_N4_Mtase; pfam01555 405955014903 Transposase DDE domain; Region: DDE_Tnp_1_5; pfam13737 405955014904 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 405955014905 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 405955014906 homodimer interface [polypeptide binding]; other site 405955014907 putative GKAP docking site [polypeptide binding]; other site 405955014908 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 405955014909 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 405955014910 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 405955014911 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 405955014912 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 405955014913 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 405955014914 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 405955014915 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 405955014916 Transposase; Region: HTH_Tnp_1; pfam01527 405955014917 Methyltransferase domain; Region: Methyltransf_27; pfam13708 405955014918 Methyltransferase domain; Region: Methyltransf_26; pfam13659 405955014919 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180 405955014920 D12 class N6 adenine-specific DNA methyltransferase; Region: MethyltransfD12; cl17344 405955014921 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 405955014922 ParB/RepB/Spo0J family partition protein; Region: parB_part; TIGR00180