-- dump date 20140619_081248 -- class Genbank::misc_feature -- table misc_feature_note -- id note 1274814000001 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1274814000002 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 1274814000003 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 1274814000004 GTP binding site; other site 1274814000005 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 1274814000006 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 1274814000007 serine/threonine protein kinase; Provisional; Region: PRK11768 1274814000008 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 1274814000009 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 1274814000010 catalytic residues [active] 1274814000011 hinge region; other site 1274814000012 alpha helical domain; other site 1274814000013 hypothetical protein; Provisional; Region: PRK11367 1274814000014 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1274814000015 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 1274814000016 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 1274814000017 putative acyl-acceptor binding pocket; other site 1274814000018 DNA polymerase I; Provisional; Region: PRK05755 1274814000019 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1274814000020 active site 1274814000021 metal binding site 1 [ion binding]; metal-binding site 1274814000022 putative 5' ssDNA interaction site; other site 1274814000023 metal binding site 3; metal-binding site 1274814000024 metal binding site 2 [ion binding]; metal-binding site 1274814000025 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1274814000026 putative DNA binding site [nucleotide binding]; other site 1274814000027 putative metal binding site [ion binding]; other site 1274814000028 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 1274814000029 active site 1274814000030 catalytic site [active] 1274814000031 substrate binding site [chemical binding]; other site 1274814000032 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 1274814000033 active site 1274814000034 DNA binding site [nucleotide binding] 1274814000035 catalytic site [active] 1274814000036 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 1274814000037 G1 box; other site 1274814000038 GTP/Mg2+ binding site [chemical binding]; other site 1274814000039 Switch I region; other site 1274814000040 G2 box; other site 1274814000041 G3 box; other site 1274814000042 Switch II region; other site 1274814000043 G4 box; other site 1274814000044 G5 box; other site 1274814000045 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 1274814000046 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 1274814000047 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814000048 FeS/SAM binding site; other site 1274814000049 HemN C-terminal domain; Region: HemN_C; pfam06969 1274814000050 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 1274814000051 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814000052 active site 1274814000053 phosphorylation site [posttranslational modification] 1274814000054 intermolecular recognition site; other site 1274814000055 dimerization interface [polypeptide binding]; other site 1274814000056 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814000057 Walker A motif; other site 1274814000058 ATP binding site [chemical binding]; other site 1274814000059 Walker B motif; other site 1274814000060 arginine finger; other site 1274814000061 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1274814000062 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 1274814000063 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1274814000064 putative active site [active] 1274814000065 heme pocket [chemical binding]; other site 1274814000066 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814000067 dimer interface [polypeptide binding]; other site 1274814000068 phosphorylation site [posttranslational modification] 1274814000069 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814000070 ATP binding site [chemical binding]; other site 1274814000071 Mg2+ binding site [ion binding]; other site 1274814000072 G-X-G motif; other site 1274814000073 glutamine synthetase; Provisional; Region: glnA; PRK09469 1274814000074 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 1274814000075 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1274814000076 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 1274814000077 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 1274814000078 G1 box; other site 1274814000079 putative GEF interaction site [polypeptide binding]; other site 1274814000080 GTP/Mg2+ binding site [chemical binding]; other site 1274814000081 Switch I region; other site 1274814000082 G2 box; other site 1274814000083 G3 box; other site 1274814000084 Switch II region; other site 1274814000085 G4 box; other site 1274814000086 G5 box; other site 1274814000087 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 1274814000088 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 1274814000089 transcriptional regulator protein; Region: phnR; TIGR03337 1274814000090 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814000091 DNA-binding site [nucleotide binding]; DNA binding site 1274814000092 UTRA domain; Region: UTRA; pfam07702 1274814000093 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1274814000094 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814000095 putative substrate translocation pore; other site 1274814000096 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 1274814000097 outer membrane porin L; Provisional; Region: ompL; PRK09980 1274814000098 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1274814000099 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814000100 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1274814000101 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1274814000102 alpha-glucosidase; Provisional; Region: PRK10426 1274814000103 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1274814000104 YihQ is a bacterial alpha-glucosidase with a conserved glycosyl hydrolase family 31 (GH31) domain that catalyzes the release of an alpha-glucosyl residue from the non-reducing end of alpha-glucoside substrates such as alpha-glucosyl fluoride. Orthologs...; Region: GH31_glucosidase_YihQ; cd06594 1274814000105 putative active site [active] 1274814000106 putative catalytic site [active] 1274814000107 Aldose 1-epimerase, similar to Escherichia coli YihR; Region: Aldose_epim_Ec_YihR; cd09022 1274814000108 active site 1274814000109 catalytic residues [active] 1274814000110 AGE domain; N-acyl-D-glucosamine 2-epimerase domain; Responsible for intermediate epimerization during biosynthesis of N-acetylneuraminic acid. Catalytic mechanism is believed to be via nucleotide elimination and readdition and is ATP modulated. AGE is...; Region: AGE; cd00249 1274814000111 dimerization interface [polypeptide binding]; other site 1274814000112 putative active cleft [active] 1274814000113 Tagatose-1,6-bisphosphate aldolase [Carbohydrate transport and metabolism]; Region: LacD; COG3684 1274814000114 catalytic residue [active] 1274814000115 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 1274814000116 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1274814000117 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1274814000118 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 1274814000119 substrate binding site [chemical binding]; other site 1274814000120 ATP binding site [chemical binding]; other site 1274814000121 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1274814000122 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1274814000123 putative DNA binding site [nucleotide binding]; other site 1274814000124 putative Zn2+ binding site [ion binding]; other site 1274814000125 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1274814000126 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1274814000127 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814000128 motif II; other site 1274814000129 hypothetical protein; Reviewed; Region: PRK01637 1274814000130 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 1274814000131 putative active site [active] 1274814000132 dimerization interface [polypeptide binding]; other site 1274814000133 putative tRNAtyr binding site [nucleotide binding]; other site 1274814000134 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814000135 Coenzyme A binding pocket [chemical binding]; other site 1274814000136 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 1274814000137 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 1274814000138 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814000139 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 1274814000140 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 1274814000141 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 1274814000142 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1274814000143 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1274814000144 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1274814000145 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1274814000146 molybdopterin cofactor binding site; other site 1274814000147 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1274814000148 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1274814000149 molybdopterin cofactor binding site; other site 1274814000150 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1274814000151 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 1274814000152 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 1274814000153 putative frv operon regulatory protein; Provisional; Region: PRK09863 1274814000154 HTH domain; Region: HTH_11; pfam08279 1274814000155 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1274814000156 active site 1274814000157 phosphorylation site [posttranslational modification] 1274814000158 putative peptidase; Provisional; Region: PRK09864 1274814000159 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1274814000160 oligomer interface [polypeptide binding]; other site 1274814000161 active site 1274814000162 metal binding site [ion binding]; metal-binding site 1274814000163 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 1274814000164 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1274814000165 active site 1274814000166 P-loop; other site 1274814000167 phosphorylation site [posttranslational modification] 1274814000168 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1274814000169 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1274814000170 active site 1274814000171 phosphorylation site [posttranslational modification] 1274814000172 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 1274814000173 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1274814000174 intersubunit interface [polypeptide binding]; other site 1274814000175 active site 1274814000176 Zn2+ binding site [ion binding]; other site 1274814000177 L-rhamnose isomerase; Provisional; Region: PRK01076 1274814000178 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 1274814000179 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 1274814000180 N- and C-terminal domain interface [polypeptide binding]; other site 1274814000181 active site 1274814000182 putative catalytic site [active] 1274814000183 metal binding site [ion binding]; metal-binding site 1274814000184 ATP binding site [chemical binding]; other site 1274814000185 rhamnulokinase; Provisional; Region: rhaB; PRK10640 1274814000186 carbohydrate binding site [chemical binding]; other site 1274814000187 transcriptional activator RhaS; Provisional; Region: PRK13503 1274814000188 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1274814000189 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814000190 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814000191 transcriptional activator RhaR; Provisional; Region: PRK13500 1274814000192 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1274814000193 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814000194 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814000195 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 1274814000196 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 1274814000197 superoxide dismutase; Provisional; Region: PRK10925 1274814000198 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1274814000199 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1274814000200 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 1274814000201 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 1274814000202 MOSC domain; Region: MOSC; pfam03473 1274814000203 3-alpha domain; Region: 3-alpha; pfam03475 1274814000204 two-component sensor protein; Provisional; Region: cpxA; PRK09470 1274814000205 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1274814000206 dimerization interface [polypeptide binding]; other site 1274814000207 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814000208 dimer interface [polypeptide binding]; other site 1274814000209 phosphorylation site [posttranslational modification] 1274814000210 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814000211 ATP binding site [chemical binding]; other site 1274814000212 Mg2+ binding site [ion binding]; other site 1274814000213 G-X-G motif; other site 1274814000214 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 1274814000215 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814000216 active site 1274814000217 intermolecular recognition site; other site 1274814000218 dimerization interface [polypeptide binding]; other site 1274814000219 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814000220 DNA binding site [nucleotide binding] 1274814000221 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1274814000222 dimer interface [polypeptide binding]; other site 1274814000223 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 1274814000224 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 1274814000225 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 1274814000226 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 1274814000227 active site 1274814000228 ADP/pyrophosphate binding site [chemical binding]; other site 1274814000229 dimerization interface [polypeptide binding]; other site 1274814000230 allosteric effector site; other site 1274814000231 fructose-1,6-bisphosphate binding site; other site 1274814000232 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1274814000233 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814000234 substrate binding pocket [chemical binding]; other site 1274814000235 membrane-bound complex binding site; other site 1274814000236 hinge residues; other site 1274814000237 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 1274814000238 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 1274814000239 triosephosphate isomerase; Provisional; Region: PRK14567 1274814000240 substrate binding site [chemical binding]; other site 1274814000241 dimer interface [polypeptide binding]; other site 1274814000242 catalytic triad [active] 1274814000243 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 1274814000244 Predicted membrane protein [Function unknown]; Region: COG3152 1274814000245 hypothetical protein; Provisional; Region: PRK09981 1274814000246 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1274814000247 Ligand Binding Site [chemical binding]; other site 1274814000248 ferredoxin-NADP reductase; Provisional; Region: PRK10926 1274814000249 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 1274814000250 FAD binding pocket [chemical binding]; other site 1274814000251 FAD binding motif [chemical binding]; other site 1274814000252 phosphate binding motif [ion binding]; other site 1274814000253 beta-alpha-beta structure motif; other site 1274814000254 NAD binding pocket [chemical binding]; other site 1274814000255 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1274814000256 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1274814000257 putative active site [active] 1274814000258 glycerol kinase; Provisional; Region: glpK; PRK00047 1274814000259 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 1274814000260 N- and C-terminal domain interface [polypeptide binding]; other site 1274814000261 active site 1274814000262 MgATP binding site [chemical binding]; other site 1274814000263 catalytic site [active] 1274814000264 metal binding site [ion binding]; metal-binding site 1274814000265 glycerol binding site [chemical binding]; other site 1274814000266 homotetramer interface [polypeptide binding]; other site 1274814000267 homodimer interface [polypeptide binding]; other site 1274814000268 FBP binding site [chemical binding]; other site 1274814000269 protein IIAGlc interface [polypeptide binding]; other site 1274814000270 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1274814000271 amphipathic channel; other site 1274814000272 Asn-Pro-Ala signature motifs; other site 1274814000273 septal ring assembly protein ZapB; Provisional; Region: PRK15422 1274814000274 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 1274814000275 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 1274814000276 UbiA prenyltransferase family; Region: UbiA; pfam01040 1274814000277 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 1274814000278 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814000279 Walker A motif; other site 1274814000280 ATP binding site [chemical binding]; other site 1274814000281 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 1274814000282 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1274814000283 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 1274814000284 active site 1274814000285 HslU subunit interaction site [polypeptide binding]; other site 1274814000286 essential cell division protein FtsN; Provisional; Region: PRK10927 1274814000287 cell division protein FtsN; Provisional; Region: PRK12757 1274814000288 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814000289 DNA binding site [nucleotide binding] 1274814000290 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 1274814000291 domain linker motif; other site 1274814000292 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 1274814000293 dimerization interface [polypeptide binding]; other site 1274814000294 ligand binding site [chemical binding]; other site 1274814000295 primosome assembly protein PriA; Validated; Region: PRK05580 1274814000296 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1274814000297 ATP binding site [chemical binding]; other site 1274814000298 putative Mg++ binding site [ion binding]; other site 1274814000299 helicase superfamily c-terminal domain; Region: HELICc; smart00490 1274814000300 ATP-binding site [chemical binding]; other site 1274814000301 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 1274814000302 RHS Repeat; Region: RHS_repeat; pfam05593 1274814000303 RHS Repeat; Region: RHS_repeat; cl11982 1274814000304 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1274814000305 RHS Repeat; Region: RHS_repeat; pfam05593 1274814000306 RHS Repeat; Region: RHS_repeat; pfam05593 1274814000307 RHS protein; Region: RHS; pfam03527 1274814000308 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1274814000309 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 1274814000310 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1274814000311 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1274814000312 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1274814000313 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1274814000314 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 1274814000315 hypothetical protein; Provisional; Region: PRK10030 1274814000316 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 1274814000317 dimerization interface [polypeptide binding]; other site 1274814000318 DNA binding site [nucleotide binding] 1274814000319 corepressor binding sites; other site 1274814000320 cystathionine gamma-synthase; Provisional; Region: PRK08045 1274814000321 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1274814000322 homodimer interface [polypeptide binding]; other site 1274814000323 substrate-cofactor binding pocket; other site 1274814000324 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814000325 catalytic residue [active] 1274814000326 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 1274814000327 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1274814000328 putative catalytic residues [active] 1274814000329 putative nucleotide binding site [chemical binding]; other site 1274814000330 putative aspartate binding site [chemical binding]; other site 1274814000331 ACT domains C-terminal to the catalytic domain of aspartokinase (AK; 4-L-aspartate-4-phosphotransferase); Region: ACT_AK-like_2; cd04892 1274814000332 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1274814000333 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1274814000334 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 1274814000335 FAD binding site [chemical binding]; other site 1274814000336 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 1274814000337 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 1274814000338 heme binding site [chemical binding]; other site 1274814000339 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 1274814000340 EamA-like transporter family; Region: EamA; pfam00892 1274814000341 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1274814000342 EamA-like transporter family; Region: EamA; pfam00892 1274814000343 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 1274814000344 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814000345 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1274814000346 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 1274814000347 dimer interface [polypeptide binding]; other site 1274814000348 active site 1274814000349 metal binding site [ion binding]; metal-binding site 1274814000350 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1274814000351 active site 1274814000352 intersubunit interactions; other site 1274814000353 catalytic residue [active] 1274814000354 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1274814000355 dimerization domain swap beta strand [polypeptide binding]; other site 1274814000356 regulatory protein interface [polypeptide binding]; other site 1274814000357 active site 1274814000358 regulatory phosphorylation site [posttranslational modification]; other site 1274814000359 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1274814000360 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 1274814000361 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1274814000362 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1274814000363 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1274814000364 active site 1274814000365 phosphorylation site [posttranslational modification] 1274814000366 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 1274814000367 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1274814000368 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1274814000369 active site 1274814000370 P-loop; other site 1274814000371 phosphorylation site [posttranslational modification] 1274814000372 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 1274814000373 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1274814000374 dimer interface [polypeptide binding]; other site 1274814000375 active site 1274814000376 glycine loop; other site 1274814000377 pyruvate formate lyase II activase; Provisional; Region: PRK10076 1274814000378 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1274814000379 active site 1274814000380 P-loop; other site 1274814000381 phosphorylation site [posttranslational modification] 1274814000382 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1274814000383 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814000384 hypothetical protein; Provisional; Region: PRK10649 1274814000385 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1274814000386 Sulfatase; Region: Sulfatase; pfam00884 1274814000387 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 1274814000388 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 1274814000389 acetylornithine deacetylase; Provisional; Region: PRK05111 1274814000390 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 1274814000391 metal binding site [ion binding]; metal-binding site 1274814000392 putative dimer interface [polypeptide binding]; other site 1274814000393 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 1274814000394 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1274814000395 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 1274814000396 nucleotide binding site [chemical binding]; other site 1274814000397 N-acetyl-L-glutamate binding site [chemical binding]; other site 1274814000398 argininosuccinate lyase; Provisional; Region: PRK04833 1274814000399 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 1274814000400 active sites [active] 1274814000401 tetramer interface [polypeptide binding]; other site 1274814000402 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1274814000403 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1274814000404 putative active site pocket [active] 1274814000405 putative metal binding site [ion binding]; other site 1274814000406 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814000407 D-galactonate transporter; Region: 2A0114; TIGR00893 1274814000408 putative substrate translocation pore; other site 1274814000409 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 1274814000410 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814000411 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 1274814000412 dimerization interface [polypeptide binding]; other site 1274814000413 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 1274814000414 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1274814000415 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1274814000416 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 1274814000417 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1274814000418 hypothetical protein; Provisional; Region: PRK11056 1274814000419 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 1274814000420 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814000421 S-adenosylmethionine binding site [chemical binding]; other site 1274814000422 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 1274814000423 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1274814000424 N-terminal plug; other site 1274814000425 ligand-binding site [chemical binding]; other site 1274814000426 glutamate racemase; Provisional; Region: PRK00865 1274814000427 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 1274814000428 FAD binding domain; Region: FAD_binding_4; pfam01565 1274814000429 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 1274814000430 Biotin operon repressor [Transcription]; Region: BirA; COG1654 1274814000431 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 1274814000432 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 1274814000433 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 1274814000434 pantothenate kinase; Provisional; Region: PRK05439 1274814000435 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 1274814000436 ATP-binding site [chemical binding]; other site 1274814000437 CoA-binding site [chemical binding]; other site 1274814000438 Mg2+-binding site [ion binding]; other site 1274814000439 potential protein location (hypothetical protein APECO78_00655 [Escherichia coli]) that overlaps RNA (tRNA-T) 1274814000440 potential protein location (hypothetical protein APECO78_00655 [Escherichia coli]) that overlaps RNA (tRNA-Y) 1274814000441 elongation factor Tu; Reviewed; Region: PRK00049 1274814000442 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1274814000443 G1 box; other site 1274814000444 GEF interaction site [polypeptide binding]; other site 1274814000445 GTP/Mg2+ binding site [chemical binding]; other site 1274814000446 Switch I region; other site 1274814000447 G2 box; other site 1274814000448 G3 box; other site 1274814000449 Switch II region; other site 1274814000450 G4 box; other site 1274814000451 G5 box; other site 1274814000452 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1274814000453 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1274814000454 Antibiotic Binding Site [chemical binding]; other site 1274814000455 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 1274814000456 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 1274814000457 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 1274814000458 putative homodimer interface [polypeptide binding]; other site 1274814000459 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 1274814000460 heterodimer interface [polypeptide binding]; other site 1274814000461 homodimer interface [polypeptide binding]; other site 1274814000462 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 1274814000463 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 1274814000464 23S rRNA interface [nucleotide binding]; other site 1274814000465 L7/L12 interface [polypeptide binding]; other site 1274814000466 putative thiostrepton binding site; other site 1274814000467 L25 interface [polypeptide binding]; other site 1274814000468 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 1274814000469 mRNA/rRNA interface [nucleotide binding]; other site 1274814000470 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 1274814000471 23S rRNA interface [nucleotide binding]; other site 1274814000472 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 1274814000473 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 1274814000474 core dimer interface [polypeptide binding]; other site 1274814000475 peripheral dimer interface [polypeptide binding]; other site 1274814000476 L10 interface [polypeptide binding]; other site 1274814000477 L11 interface [polypeptide binding]; other site 1274814000478 putative EF-Tu interaction site [polypeptide binding]; other site 1274814000479 putative EF-G interaction site [polypeptide binding]; other site 1274814000480 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 1274814000481 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 1274814000482 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 1274814000483 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1274814000484 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 1274814000485 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 1274814000486 RPB3 interaction site [polypeptide binding]; other site 1274814000487 RPB1 interaction site [polypeptide binding]; other site 1274814000488 RPB11 interaction site [polypeptide binding]; other site 1274814000489 RPB10 interaction site [polypeptide binding]; other site 1274814000490 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 1274814000491 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 1274814000492 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 1274814000493 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 1274814000494 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 1274814000495 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 1274814000496 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1274814000497 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 1274814000498 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 1274814000499 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 1274814000500 DNA binding site [nucleotide binding] 1274814000501 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 1274814000502 stationary phase growth adaptation protein; Provisional; Region: PRK09717 1274814000503 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 1274814000504 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814000505 FeS/SAM binding site; other site 1274814000506 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 1274814000507 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 1274814000508 ThiS interaction site; other site 1274814000509 putative active site [active] 1274814000510 tetramer interface [polypeptide binding]; other site 1274814000511 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 1274814000512 thiS-thiF/thiG interaction site; other site 1274814000513 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1274814000514 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 1274814000515 ATP binding site [chemical binding]; other site 1274814000516 substrate interface [chemical binding]; other site 1274814000517 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 1274814000518 thiamine phosphate binding site [chemical binding]; other site 1274814000519 active site 1274814000520 pyrophosphate binding site [ion binding]; other site 1274814000521 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 1274814000522 ThiC-associated domain; Region: ThiC-associated; pfam13667 1274814000523 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 1274814000524 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 1274814000525 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 1274814000526 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 1274814000527 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 1274814000528 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 1274814000529 putative NADH binding site [chemical binding]; other site 1274814000530 putative active site [active] 1274814000531 nudix motif; other site 1274814000532 putative metal binding site [ion binding]; other site 1274814000533 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 1274814000534 substrate binding site [chemical binding]; other site 1274814000535 active site 1274814000536 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 1274814000537 Active_site [active] 1274814000538 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 1274814000539 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1274814000540 IHF dimer interface [polypeptide binding]; other site 1274814000541 IHF - DNA interface [nucleotide binding]; other site 1274814000542 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 1274814000543 zinc resistance protein; Provisional; Region: zraP; PRK11546 1274814000544 dimer interface [polypeptide binding]; other site 1274814000545 sensor protein ZraS; Provisional; Region: PRK10364 1274814000546 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814000547 dimer interface [polypeptide binding]; other site 1274814000548 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814000549 ATP binding site [chemical binding]; other site 1274814000550 Mg2+ binding site [ion binding]; other site 1274814000551 G-X-G motif; other site 1274814000552 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 1274814000553 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814000554 active site 1274814000555 phosphorylation site [posttranslational modification] 1274814000556 intermolecular recognition site; other site 1274814000557 dimerization interface [polypeptide binding]; other site 1274814000558 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814000559 Walker A motif; other site 1274814000560 ATP binding site [chemical binding]; other site 1274814000561 Walker B motif; other site 1274814000562 arginine finger; other site 1274814000563 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1274814000564 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 1274814000565 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 1274814000566 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 1274814000567 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 1274814000568 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 1274814000569 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 1274814000570 purine monophosphate binding site [chemical binding]; other site 1274814000571 dimer interface [polypeptide binding]; other site 1274814000572 putative catalytic residues [active] 1274814000573 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 1274814000574 hypothetical protein; Provisional; Region: PRK10039 1274814000575 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1274814000576 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814000577 Coenzyme A binding pocket [chemical binding]; other site 1274814000578 homoserine O-succinyltransferase; Provisional; Region: PRK05368 1274814000579 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 1274814000580 proposed active site lysine [active] 1274814000581 conserved cys residue [active] 1274814000582 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 1274814000583 malate synthase A; Region: malate_syn_A; TIGR01344 1274814000584 active site 1274814000585 isocitrate lyase; Provisional; Region: PRK15063 1274814000586 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1274814000587 tetramer interface [polypeptide binding]; other site 1274814000588 active site 1274814000589 Mg2+/Mn2+ binding site [ion binding]; other site 1274814000590 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 1274814000591 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 1274814000592 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 1274814000593 transcriptional repressor IclR; Provisional; Region: PRK11569 1274814000594 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1274814000595 Bacterial transcriptional regulator; Region: IclR; pfam01614 1274814000596 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 1274814000597 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 1274814000598 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 1274814000599 substrate binding pocket [chemical binding]; other site 1274814000600 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 1274814000601 B12 binding site [chemical binding]; other site 1274814000602 cobalt ligand [ion binding]; other site 1274814000603 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 1274814000604 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 1274814000605 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1274814000606 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 1274814000607 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 1274814000608 active site pocket [active] 1274814000609 oxyanion hole [active] 1274814000610 catalytic triad [active] 1274814000611 active site nucleophile [active] 1274814000612 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814000613 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 1274814000614 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1274814000615 putative NAD(P) binding site [chemical binding]; other site 1274814000616 catalytic Zn binding site [ion binding]; other site 1274814000617 PTS system, mannose/fructose/sorbose family, IID component; Region: EIID-AGA; TIGR00828 1274814000618 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1274814000619 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1274814000620 active site 1274814000621 phosphorylation site [posttranslational modification] 1274814000622 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1274814000623 active pocket/dimerization site; other site 1274814000624 active site 1274814000625 phosphorylation site [posttranslational modification] 1274814000626 sorbitol-6-phosphate 2-dehydrogenase; Provisional; Region: PRK06171 1274814000627 classical (c) SDRs; Region: SDR_c; cd05233 1274814000628 NAD(P) binding site [chemical binding]; other site 1274814000629 active site 1274814000630 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1274814000631 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1274814000632 putative DNA binding site [nucleotide binding]; other site 1274814000633 putative Zn2+ binding site [ion binding]; other site 1274814000634 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1274814000635 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 1274814000636 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1274814000637 RNA binding surface [nucleotide binding]; other site 1274814000638 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 1274814000639 probable active site [active] 1274814000640 hypothetical protein; Provisional; Region: PRK10515 1274814000641 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1274814000642 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1274814000643 Predicted nucleotidyltransferase; Region: Nuc-transf; pfam10127 1274814000644 Zeta toxin; Region: Zeta_toxin; pfam06414 1274814000645 aspartate kinase III; Validated; Region: PRK09084 1274814000646 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1274814000647 nucleotide binding site [chemical binding]; other site 1274814000648 substrate binding site [chemical binding]; other site 1274814000649 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1274814000650 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 1274814000651 dimer interface [polypeptide binding]; other site 1274814000652 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 1274814000653 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 1274814000654 active site 1274814000655 dimer interface [polypeptide binding]; other site 1274814000656 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 1274814000657 dimer interface [polypeptide binding]; other site 1274814000658 active site 1274814000659 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1274814000660 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1274814000661 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1274814000662 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1274814000663 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 1274814000664 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 1274814000665 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814000666 putative substrate translocation pore; other site 1274814000667 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814000668 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1274814000669 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814000670 dimer interface [polypeptide binding]; other site 1274814000671 conserved gate region; other site 1274814000672 putative PBP binding loops; other site 1274814000673 ABC-ATPase subunit interface; other site 1274814000674 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814000675 dimer interface [polypeptide binding]; other site 1274814000676 conserved gate region; other site 1274814000677 putative PBP binding loops; other site 1274814000678 ABC-ATPase subunit interface; other site 1274814000679 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 1274814000680 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 1274814000681 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1274814000682 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 1274814000683 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1274814000684 Walker A/P-loop; other site 1274814000685 ATP binding site [chemical binding]; other site 1274814000686 Q-loop/lid; other site 1274814000687 ABC transporter signature motif; other site 1274814000688 Walker B; other site 1274814000689 D-loop; other site 1274814000690 H-loop/switch region; other site 1274814000691 TOBE domain; Region: TOBE_2; pfam08402 1274814000692 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1274814000693 trimer interface; other site 1274814000694 sugar binding site [chemical binding]; other site 1274814000695 maltose regulon periplasmic protein; Provisional; Region: PRK10564 1274814000696 hypothetical protein; Validated; Region: PRK09718 1274814000697 Pentapeptide repeats containing protein [Function unknown]; Region: COG1357 1274814000698 SopA-like central domain; Region: SopA; pfam13981 1274814000699 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 1274814000700 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 1274814000701 UbiA prenyltransferase family; Region: UbiA; pfam01040 1274814000702 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 1274814000703 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 1274814000704 putative acyl-acceptor binding pocket; other site 1274814000705 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 1274814000706 LexA repressor; Validated; Region: PRK00215 1274814000707 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1274814000708 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1274814000709 Catalytic site [active] 1274814000710 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 1274814000711 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 1274814000712 hypothetical protein; Provisional; Region: PRK10428 1274814000713 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1274814000714 metal binding site 2 [ion binding]; metal-binding site 1274814000715 putative DNA binding helix; other site 1274814000716 metal binding site 1 [ion binding]; metal-binding site 1274814000717 dimer interface [polypeptide binding]; other site 1274814000718 structural Zn2+ binding site [ion binding]; other site 1274814000719 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 1274814000720 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1274814000721 Uncharacterized phage-associated protein [Function unknown]; Region: GepA; COG3600 1274814000722 Pyocin activator protein PrtN; Region: PyocinActivator; pfam11112 1274814000723 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 1274814000724 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1274814000725 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1274814000726 Catalytic site [active] 1274814000727 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1274814000728 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 1274814000729 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1274814000730 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1274814000731 potential frameshift: common BLAST hit: gi|386602472|ref|YP_006103978.1| putative reverse transcriptase 1274814000732 IS2 repressor TnpA; Reviewed; Region: PRK09413 1274814000733 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814000734 IS2 transposase TnpB; Reviewed; Region: PRK09409 1274814000735 HTH-like domain; Region: HTH_21; pfam13276 1274814000736 Integrase core domain; Region: rve; pfam00665 1274814000737 Integrase core domain; Region: rve_3; pfam13683 1274814000738 DinI-like family; Region: DinI; pfam06183 1274814000739 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1274814000740 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1274814000741 active site 1274814000742 DNA binding site [nucleotide binding] 1274814000743 Int/Topo IB signature motif; other site 1274814000744 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 1274814000745 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1274814000746 FMN binding site [chemical binding]; other site 1274814000747 active site 1274814000748 catalytic residues [active] 1274814000749 substrate binding site [chemical binding]; other site 1274814000750 phage shock protein G; Reviewed; Region: pspG; PRK09459 1274814000751 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 1274814000752 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 1274814000753 NADP binding site [chemical binding]; other site 1274814000754 dimer interface [polypeptide binding]; other site 1274814000755 replicative DNA helicase; Provisional; Region: PRK08006 1274814000756 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 1274814000757 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 1274814000758 Walker A motif; other site 1274814000759 ATP binding site [chemical binding]; other site 1274814000760 Walker B motif; other site 1274814000761 DNA binding loops [nucleotide binding] 1274814000762 alanine racemase; Reviewed; Region: alr; PRK00053 1274814000763 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1274814000764 active site 1274814000765 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1274814000766 substrate binding site [chemical binding]; other site 1274814000767 catalytic residues [active] 1274814000768 dimer interface [polypeptide binding]; other site 1274814000769 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1274814000770 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1274814000771 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814000772 homodimer interface [polypeptide binding]; other site 1274814000773 catalytic residue [active] 1274814000774 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814000775 active site 1274814000776 motif I; other site 1274814000777 motif II; other site 1274814000778 Uncharacterized protein family UPF0047; Region: UPF0047; cl00439 1274814000779 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 1274814000780 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 1274814000781 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1274814000782 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 1274814000783 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 1274814000784 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 1274814000785 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1274814000786 dimer interface [polypeptide binding]; other site 1274814000787 ssDNA binding site [nucleotide binding]; other site 1274814000788 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1274814000789 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 1274814000790 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1274814000791 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1274814000792 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814000793 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 1274814000794 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814000795 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 1274814000796 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 1274814000797 DNA binding residues [nucleotide binding] 1274814000798 dimer interface [polypeptide binding]; other site 1274814000799 [2Fe-2S] cluster binding site [ion binding]; other site 1274814000800 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1274814000801 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 1274814000802 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1274814000803 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 1274814000804 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 1274814000805 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1274814000806 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 1274814000807 Na binding site [ion binding]; other site 1274814000808 Predicted membrane protein [Function unknown]; Region: COG3162 1274814000809 acetyl-CoA synthetase; Provisional; Region: PRK00174 1274814000810 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 1274814000811 active site 1274814000812 CoA binding site [chemical binding]; other site 1274814000813 acyl-activating enzyme (AAE) consensus motif; other site 1274814000814 AMP binding site [chemical binding]; other site 1274814000815 acetate binding site [chemical binding]; other site 1274814000816 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 1274814000817 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 1274814000818 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1274814000819 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 1274814000820 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 1274814000821 heme lyase subunit NrfE; Provisional; Region: PRK10369 1274814000822 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 1274814000823 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1274814000824 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1274814000825 binding surface 1274814000826 TPR motif; other site 1274814000827 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 1274814000828 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1274814000829 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1274814000830 Sel1-like repeats; Region: SEL1; smart00671 1274814000831 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1274814000832 molybdopterin cofactor binding site; other site 1274814000833 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 1274814000834 molybdopterin cofactor binding site; other site 1274814000835 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1274814000836 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 1274814000837 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 1274814000838 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1274814000839 multidrug resistance protein MdtN; Provisional; Region: PRK10476 1274814000840 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1274814000841 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814000842 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 1274814000843 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1274814000844 D-allose kinase; Provisional; Region: PRK09698 1274814000845 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1274814000846 nucleotide binding site [chemical binding]; other site 1274814000847 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1274814000848 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1274814000849 substrate binding site [chemical binding]; other site 1274814000850 hexamer interface [polypeptide binding]; other site 1274814000851 metal binding site [ion binding]; metal-binding site 1274814000852 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1274814000853 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1274814000854 TM-ABC transporter signature motif; other site 1274814000855 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 1274814000856 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814000857 Walker A/P-loop; other site 1274814000858 ATP binding site [chemical binding]; other site 1274814000859 Q-loop/lid; other site 1274814000860 ABC transporter signature motif; other site 1274814000861 Walker B; other site 1274814000862 D-loop; other site 1274814000863 H-loop/switch region; other site 1274814000864 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1274814000865 D-allose transporter subunit; Provisional; Region: PRK09701 1274814000866 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 1274814000867 ligand binding site [chemical binding]; other site 1274814000868 dimerization interface [polypeptide binding]; other site 1274814000869 zinc binding site [ion binding]; other site 1274814000870 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 1274814000871 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1274814000872 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1274814000873 putative active site [active] 1274814000874 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 1274814000875 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 1274814000876 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814000877 Coenzyme A binding pocket [chemical binding]; other site 1274814000878 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 1274814000879 AAA domain; Region: AAA_18; pfam13238 1274814000880 active site 1274814000881 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 1274814000882 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1274814000883 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 1274814000884 active site 1274814000885 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 1274814000886 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1274814000887 Walker A/P-loop; other site 1274814000888 ATP binding site [chemical binding]; other site 1274814000889 Q-loop/lid; other site 1274814000890 ABC transporter signature motif; other site 1274814000891 Walker B; other site 1274814000892 D-loop; other site 1274814000893 H-loop/switch region; other site 1274814000894 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 1274814000895 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814000896 Walker A/P-loop; other site 1274814000897 ATP binding site [chemical binding]; other site 1274814000898 Q-loop/lid; other site 1274814000899 ABC transporter signature motif; other site 1274814000900 Walker B; other site 1274814000901 D-loop; other site 1274814000902 H-loop/switch region; other site 1274814000903 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1274814000904 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 1274814000905 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 1274814000906 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 1274814000907 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 1274814000908 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 1274814000909 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814000910 DNA-binding site [nucleotide binding]; DNA binding site 1274814000911 UTRA domain; Region: UTRA; pfam07702 1274814000912 phosphonate ABC transporter, permease protein PhnE; Region: PhnE; TIGR01097 1274814000913 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814000914 dimer interface [polypeptide binding]; other site 1274814000915 conserved gate region; other site 1274814000916 putative PBP binding loops; other site 1274814000917 ABC-ATPase subunit interface; other site 1274814000918 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 1274814000919 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814000920 substrate binding pocket [chemical binding]; other site 1274814000921 membrane-bound complex binding site; other site 1274814000922 hinge residues; other site 1274814000923 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 1274814000924 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 1274814000925 Walker A/P-loop; other site 1274814000926 ATP binding site [chemical binding]; other site 1274814000927 Q-loop/lid; other site 1274814000928 ABC transporter signature motif; other site 1274814000929 Walker B; other site 1274814000930 D-loop; other site 1274814000931 H-loop/switch region; other site 1274814000932 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 1274814000933 dimer interface [polypeptide binding]; other site 1274814000934 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1274814000935 hypothetical protein; Provisional; Region: PRK10220 1274814000936 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 1274814000937 PhnA protein; Region: PhnA; pfam03831 1274814000938 hypothetical protein; Provisional; Region: PRK09866 1274814000939 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1274814000940 G1 box; other site 1274814000941 GTP/Mg2+ binding site [chemical binding]; other site 1274814000942 G2 box; other site 1274814000943 Switch I region; other site 1274814000944 G3 box; other site 1274814000945 Switch II region; other site 1274814000946 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1274814000947 G2 box; other site 1274814000948 Switch I region; other site 1274814000949 G3 box; other site 1274814000950 Switch II region; other site 1274814000951 G4 box; other site 1274814000952 G5 box; other site 1274814000953 YjcZ-like protein; Region: YjcZ; pfam13990 1274814000954 proline/glycine betaine transporter; Provisional; Region: PRK10642 1274814000955 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814000956 putative substrate translocation pore; other site 1274814000957 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 1274814000958 sensor protein BasS/PmrB; Provisional; Region: PRK10755 1274814000959 HAMP domain; Region: HAMP; pfam00672 1274814000960 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814000961 dimer interface [polypeptide binding]; other site 1274814000962 phosphorylation site [posttranslational modification] 1274814000963 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814000964 ATP binding site [chemical binding]; other site 1274814000965 Mg2+ binding site [ion binding]; other site 1274814000966 G-X-G motif; other site 1274814000967 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 1274814000968 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814000969 active site 1274814000970 phosphorylation site [posttranslational modification] 1274814000971 intermolecular recognition site; other site 1274814000972 dimerization interface [polypeptide binding]; other site 1274814000973 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814000974 DNA binding site [nucleotide binding] 1274814000975 putative metal dependent hydrolase; Provisional; Region: PRK11598 1274814000976 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1274814000977 Sulfatase; Region: Sulfatase; pfam00884 1274814000978 arginine:agmatin antiporter; Provisional; Region: PRK10644 1274814000979 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1274814000980 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814000981 arginine decarboxylase; Provisional; Region: PRK15029 1274814000982 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1274814000983 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1274814000984 homodimer interface [polypeptide binding]; other site 1274814000985 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814000986 catalytic residue [active] 1274814000987 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1274814000988 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 1274814000989 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814000990 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814000991 alpha-galactosidase; Provisional; Region: PRK15076 1274814000992 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 1274814000993 NAD binding site [chemical binding]; other site 1274814000994 sugar binding site [chemical binding]; other site 1274814000995 divalent metal binding site [ion binding]; other site 1274814000996 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 1274814000997 dimer interface [polypeptide binding]; other site 1274814000998 melibiose:sodium symporter; Provisional; Region: PRK10429 1274814000999 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 1274814001000 hypothetical protein; Provisional; Region: PRK09867 1274814001001 fumarate hydratase; Provisional; Region: PRK15389 1274814001002 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1274814001003 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1274814001004 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1274814001005 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 1274814001006 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 1274814001007 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814001008 active site 1274814001009 phosphorylation site [posttranslational modification] 1274814001010 intermolecular recognition site; other site 1274814001011 dimerization interface [polypeptide binding]; other site 1274814001012 Transcriptional regulator; Region: CitT; pfam12431 1274814001013 sensory histidine kinase DcuS; Provisional; Region: PRK11086 1274814001014 PAS domain; Region: PAS; smart00091 1274814001015 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814001016 ATP binding site [chemical binding]; other site 1274814001017 Mg2+ binding site [ion binding]; other site 1274814001018 G-X-G motif; other site 1274814001019 Uncharacterized conserved protein [Function unknown]; Region: COG3592 1274814001020 Predicted acetyltransferase [General function prediction only]; Region: COG2388 1274814001021 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1274814001022 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1274814001023 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 1274814001024 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1274814001025 dimer interface [polypeptide binding]; other site 1274814001026 putative anticodon binding site; other site 1274814001027 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1274814001028 motif 1; other site 1274814001029 active site 1274814001030 motif 2; other site 1274814001031 motif 3; other site 1274814001032 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1274814001033 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814001034 putative substrate translocation pore; other site 1274814001035 POT family; Region: PTR2; pfam00854 1274814001036 lysine decarboxylase CadA; Provisional; Region: PRK15400 1274814001037 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1274814001038 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1274814001039 homodimer interface [polypeptide binding]; other site 1274814001040 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814001041 catalytic residue [active] 1274814001042 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1274814001043 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 1274814001044 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 1274814001045 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814001046 DNA binding site [nucleotide binding] 1274814001047 putative transcriptional regulator; Provisional; Region: PRK11640 1274814001048 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1274814001049 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 1274814001050 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 1274814001051 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 1274814001052 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 1274814001053 DsbD alpha interface [polypeptide binding]; other site 1274814001054 catalytic residues [active] 1274814001055 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 1274814001056 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 1274814001057 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 1274814001058 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 1274814001059 Aspartase; Region: Aspartase; cd01357 1274814001060 active sites [active] 1274814001061 tetramer interface [polypeptide binding]; other site 1274814001062 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 1274814001063 putative transporter; Provisional; Region: PRK11021 1274814001064 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 1274814001065 oligomerisation interface [polypeptide binding]; other site 1274814001066 mobile loop; other site 1274814001067 roof hairpin; other site 1274814001068 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 1274814001069 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 1274814001070 ring oligomerisation interface [polypeptide binding]; other site 1274814001071 ATP/Mg binding site [chemical binding]; other site 1274814001072 stacking interactions; other site 1274814001073 hinge regions; other site 1274814001074 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 1274814001075 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814001076 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 1274814001077 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814001078 FeS/SAM binding site; other site 1274814001079 elongation factor P; Validated; Region: PRK00529 1274814001080 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1274814001081 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1274814001082 RNA binding site [nucleotide binding]; other site 1274814001083 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1274814001084 RNA binding site [nucleotide binding]; other site 1274814001085 entericidin A; Provisional; Region: PRK09810 1274814001086 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 1274814001087 multidrug efflux system protein; Provisional; Region: PRK11431 1274814001088 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 1274814001089 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 1274814001090 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 1274814001091 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1274814001092 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 1274814001093 Iron-sulfur protein interface; other site 1274814001094 proximal quinone binding site [chemical binding]; other site 1274814001095 C-subunit interface; other site 1274814001096 distal quinone binding site; other site 1274814001097 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 1274814001098 D-subunit interface [polypeptide binding]; other site 1274814001099 Iron-sulfur protein interface; other site 1274814001100 proximal quinone binding site [chemical binding]; other site 1274814001101 distal quinone binding site [chemical binding]; other site 1274814001102 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 1274814001103 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1274814001104 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 1274814001105 L-aspartate oxidase; Provisional; Region: PRK06175 1274814001106 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1274814001107 poxB regulator PoxA; Provisional; Region: PRK09350 1274814001108 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1274814001109 motif 1; other site 1274814001110 dimer interface [polypeptide binding]; other site 1274814001111 active site 1274814001112 motif 2; other site 1274814001113 motif 3; other site 1274814001114 inner membrane transporter YjeM; Provisional; Region: PRK15238 1274814001115 putative mechanosensitive channel protein; Provisional; Region: PRK10929 1274814001116 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 1274814001117 DNA-binding site [nucleotide binding]; DNA binding site 1274814001118 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1274814001119 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1274814001120 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 1274814001121 GTPase RsgA; Reviewed; Region: PRK12288 1274814001122 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1274814001123 RNA binding site [nucleotide binding]; other site 1274814001124 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 1274814001125 GTPase/Zn-binding domain interface [polypeptide binding]; other site 1274814001126 GTP/Mg2+ binding site [chemical binding]; other site 1274814001127 G4 box; other site 1274814001128 G5 box; other site 1274814001129 G1 box; other site 1274814001130 Switch I region; other site 1274814001131 G2 box; other site 1274814001132 G3 box; other site 1274814001133 Switch II region; other site 1274814001134 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 1274814001135 catalytic site [active] 1274814001136 putative active site [active] 1274814001137 putative substrate binding site [chemical binding]; other site 1274814001138 dimer interface [polypeptide binding]; other site 1274814001139 epoxyqueuosine reductase; Region: TIGR00276 1274814001140 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 1274814001141 putative carbohydrate kinase; Provisional; Region: PRK10565 1274814001142 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 1274814001143 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 1274814001144 putative substrate binding site [chemical binding]; other site 1274814001145 putative ATP binding site [chemical binding]; other site 1274814001146 ADP-binding protein; Provisional; Region: PRK10646 1274814001147 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 1274814001148 AMIN domain; Region: AMIN; pfam11741 1274814001149 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1274814001150 active site 1274814001151 metal binding site [ion binding]; metal-binding site 1274814001152 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 1274814001153 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814001154 ATP binding site [chemical binding]; other site 1274814001155 Mg2+ binding site [ion binding]; other site 1274814001156 G-X-G motif; other site 1274814001157 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 1274814001158 ATP binding site [chemical binding]; other site 1274814001159 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 1274814001160 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 1274814001161 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 1274814001162 bacterial Hfq-like; Region: Hfq; cd01716 1274814001163 hexamer interface [polypeptide binding]; other site 1274814001164 Sm1 motif; other site 1274814001165 RNA binding site [nucleotide binding]; other site 1274814001166 Sm2 motif; other site 1274814001167 GTPase HflX; Provisional; Region: PRK11058 1274814001168 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 1274814001169 HflX GTPase family; Region: HflX; cd01878 1274814001170 G1 box; other site 1274814001171 GTP/Mg2+ binding site [chemical binding]; other site 1274814001172 Switch I region; other site 1274814001173 G2 box; other site 1274814001174 G3 box; other site 1274814001175 Switch II region; other site 1274814001176 G4 box; other site 1274814001177 G5 box; other site 1274814001178 FtsH protease regulator HflK; Provisional; Region: PRK10930 1274814001179 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 1274814001180 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 1274814001181 FtsH protease regulator HflC; Provisional; Region: PRK11029 1274814001182 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 1274814001183 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 1274814001184 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 1274814001185 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 1274814001186 GDP-binding site [chemical binding]; other site 1274814001187 ACT binding site; other site 1274814001188 IMP binding site; other site 1274814001189 Predicted transcriptional regulator [Transcription]; Region: COG1959 1274814001190 transcriptional repressor NsrR; Provisional; Region: PRK11014 1274814001191 exoribonuclease R; Provisional; Region: PRK11642 1274814001192 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 1274814001193 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1274814001194 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 1274814001195 RNB domain; Region: RNB; pfam00773 1274814001196 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 1274814001197 RNA binding site [nucleotide binding]; other site 1274814001198 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 1274814001199 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 1274814001200 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1274814001201 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 1274814001202 PspA/IM30 family; Region: PspA_IM30; pfam04012 1274814001203 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 1274814001204 Predicted membrane protein [Function unknown]; Region: COG3766 1274814001205 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1274814001206 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 1274814001207 Predicted integral membrane protein [Function unknown]; Region: COG5463 1274814001208 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1274814001209 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 1274814001210 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 1274814001211 FAD binding site [chemical binding]; other site 1274814001212 substrate binding site [chemical binding]; other site 1274814001213 catalytic residues [active] 1274814001214 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1274814001215 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 1274814001216 esterase; Provisional; Region: PRK10566 1274814001217 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1274814001218 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1274814001219 transcriptional repressor UlaR; Provisional; Region: PRK13509 1274814001220 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1274814001221 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1274814001222 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 1274814001223 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 1274814001224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 1274814001225 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 1274814001226 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 1274814001227 active site 1274814001228 P-loop; other site 1274814001229 phosphorylation site [posttranslational modification] 1274814001230 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1274814001231 active site 1274814001232 phosphorylation site [posttranslational modification] 1274814001233 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1274814001234 active site 1274814001235 dimer interface [polypeptide binding]; other site 1274814001236 magnesium binding site [ion binding]; other site 1274814001237 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 1274814001238 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1274814001239 AP (apurinic/apyrimidinic) site pocket; other site 1274814001240 DNA interaction; other site 1274814001241 Metal-binding active site; metal-binding site 1274814001242 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1274814001243 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1274814001244 intersubunit interface [polypeptide binding]; other site 1274814001245 active site 1274814001246 Zn2+ binding site [ion binding]; other site 1274814001247 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1274814001248 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 1274814001249 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 1274814001250 dimer interface [polypeptide binding]; other site 1274814001251 ssDNA binding site [nucleotide binding]; other site 1274814001252 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1274814001253 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 1274814001254 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 1274814001255 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 1274814001256 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 1274814001257 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1274814001258 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 1274814001259 DctM-like transporters; Region: DctM; pfam06808 1274814001260 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 1274814001261 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 1274814001262 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 1274814001263 L-aspartate oxidase; Provisional; Region: PRK06175 1274814001264 L-aspartate oxidase; Provisional; Region: PRK06175 1274814001265 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1274814001266 Coenzyme A transferase; Region: CoA_trans; smart00882 1274814001267 Coenzyme A transferase; Region: CoA_trans; cl17247 1274814001268 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 1274814001269 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1274814001270 substrate binding site [chemical binding]; other site 1274814001271 oxyanion hole (OAH) forming residues; other site 1274814001272 trimer interface [polypeptide binding]; other site 1274814001273 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1274814001274 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 1274814001275 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 1274814001276 putative NAD(P) binding site [chemical binding]; other site 1274814001277 active site 1274814001278 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1274814001279 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1274814001280 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 1274814001281 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 1274814001282 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 1274814001283 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1274814001284 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1274814001285 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 1274814001286 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814001287 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 1274814001288 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 1274814001289 Hemerythrin-like domain; Region: Hr-like; cd12108 1274814001290 Fe binding site [ion binding]; other site 1274814001291 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1274814001292 EamA-like transporter family; Region: EamA; pfam00892 1274814001293 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1274814001294 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 1274814001295 NADP binding site [chemical binding]; other site 1274814001296 Predicted transcriptional regulators [Transcription]; Region: COG1733 1274814001297 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 1274814001298 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 1274814001299 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 1274814001300 active site 1274814001301 metal binding site [ion binding]; metal-binding site 1274814001302 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1274814001303 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 1274814001304 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1274814001305 active site 1274814001306 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 1274814001307 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 1274814001308 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1274814001309 Domain of unknown function DUF21; Region: DUF21; pfam01595 1274814001310 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1274814001311 Transporter associated domain; Region: CorC_HlyC; smart01091 1274814001312 methionine sulfoxide reductase A; Provisional; Region: PRK00058 1274814001313 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 1274814001314 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1274814001315 Surface antigen; Region: Bac_surface_Ag; pfam01103 1274814001316 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 1274814001317 Family of unknown function (DUF490); Region: DUF490; pfam04357 1274814001318 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1274814001319 putative active site pocket [active] 1274814001320 dimerization interface [polypeptide binding]; other site 1274814001321 putative catalytic residue [active] 1274814001322 antitoxin ChpS; Provisional; Region: PRK11347 1274814001323 toxin ChpB; Provisional; Region: PRK09812 1274814001324 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 1274814001325 dimer interface [polypeptide binding]; other site 1274814001326 substrate binding site [chemical binding]; other site 1274814001327 metal binding sites [ion binding]; metal-binding site 1274814001328 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 1274814001329 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 1274814001330 putative ligand binding site [chemical binding]; other site 1274814001331 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1274814001332 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1274814001333 Walker A/P-loop; other site 1274814001334 ATP binding site [chemical binding]; other site 1274814001335 Q-loop/lid; other site 1274814001336 ABC transporter signature motif; other site 1274814001337 Walker B; other site 1274814001338 D-loop; other site 1274814001339 H-loop/switch region; other site 1274814001340 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1274814001341 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1274814001342 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1274814001343 TM-ABC transporter signature motif; other site 1274814001344 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1274814001345 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1274814001346 TM-ABC transporter signature motif; other site 1274814001347 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 1274814001348 AMP binding site [chemical binding]; other site 1274814001349 metal binding site [ion binding]; metal-binding site 1274814001350 active site 1274814001351 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 1274814001352 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1274814001353 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1274814001354 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1274814001355 hypothetical protein; Provisional; Region: PRK05255 1274814001356 peptidase PmbA; Provisional; Region: PRK11040 1274814001357 cytochrome b562; Provisional; Region: PRK15058 1274814001358 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 1274814001359 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814001360 FeS/SAM binding site; other site 1274814001361 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 1274814001362 ATP cone domain; Region: ATP-cone; pfam03477 1274814001363 Class III ribonucleotide reductase; Region: RNR_III; cd01675 1274814001364 effector binding site; other site 1274814001365 active site 1274814001366 Zn binding site [ion binding]; other site 1274814001367 glycine loop; other site 1274814001368 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 1274814001369 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 1274814001370 Ca binding site [ion binding]; other site 1274814001371 active site 1274814001372 catalytic site [active] 1274814001373 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 1274814001374 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1274814001375 active site turn [active] 1274814001376 phosphorylation site [posttranslational modification] 1274814001377 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1274814001378 trehalose repressor; Provisional; Region: treR; PRK09492 1274814001379 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814001380 DNA binding site [nucleotide binding] 1274814001381 domain linker motif; other site 1274814001382 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 1274814001383 dimerization interface [polypeptide binding]; other site 1274814001384 ligand binding site [chemical binding]; other site 1274814001385 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 1274814001386 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 1274814001387 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1274814001388 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 1274814001389 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814001390 motif II; other site 1274814001391 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 1274814001392 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1274814001393 homotrimer interaction site [polypeptide binding]; other site 1274814001394 putative active site [active] 1274814001395 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 1274814001396 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 1274814001397 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 1274814001398 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 1274814001399 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1274814001400 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1274814001401 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 1274814001402 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 1274814001403 homotrimer interaction site [polypeptide binding]; other site 1274814001404 putative active site [active] 1274814001405 oxidoreductase; Provisional; Region: PRK12742 1274814001406 classical (c) SDRs; Region: SDR_c; cd05233 1274814001407 NAD(P) binding site [chemical binding]; other site 1274814001408 active site 1274814001409 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1274814001410 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1274814001411 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 1274814001412 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 1274814001413 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1274814001414 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1274814001415 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 1274814001416 RNase E inhibitor protein; Provisional; Region: PRK11191 1274814001417 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1274814001418 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814001419 Coenzyme A binding pocket [chemical binding]; other site 1274814001420 Predicted membrane protein [Function unknown]; Region: COG4269 1274814001421 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 1274814001422 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1274814001423 HIGH motif; other site 1274814001424 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1274814001425 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 1274814001426 active site 1274814001427 KMSKS motif; other site 1274814001428 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 1274814001429 tRNA binding surface [nucleotide binding]; other site 1274814001430 anticodon binding site; other site 1274814001431 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 1274814001432 DNA polymerase III subunit chi; Validated; Region: PRK05728 1274814001433 multifunctional aminopeptidase A; Provisional; Region: PRK00913 1274814001434 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1274814001435 interface (dimer of trimers) [polypeptide binding]; other site 1274814001436 Substrate-binding/catalytic site; other site 1274814001437 Zn-binding sites [ion binding]; other site 1274814001438 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 1274814001439 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1274814001440 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 1274814001441 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1274814001442 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 1274814001443 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1274814001444 Walker A motif; other site 1274814001445 ATP binding site [chemical binding]; other site 1274814001446 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1274814001447 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814001448 DNA binding site [nucleotide binding] 1274814001449 domain linker motif; other site 1274814001450 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1274814001451 putative dimerization interface [polypeptide binding]; other site 1274814001452 putative ligand binding site [chemical binding]; other site 1274814001453 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1274814001454 gluconate transporter; Region: gntP; TIGR00791 1274814001455 gluconate 5-dehydrogenase; Provisional; Region: PRK08085 1274814001456 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1274814001457 NADP binding site [chemical binding]; other site 1274814001458 homodimer interface [polypeptide binding]; other site 1274814001459 active site 1274814001460 L-idonate 5-dehydrogenase; Provisional; Region: PRK09880 1274814001461 L-idonate 5-dehydrogenase; Region: idonate-5-DH; cd08232 1274814001462 putative NAD(P) binding site [chemical binding]; other site 1274814001463 catalytic Zn binding site [ion binding]; other site 1274814001464 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1274814001465 ATP-binding site [chemical binding]; other site 1274814001466 Gluconate-6-phosphate binding site [chemical binding]; other site 1274814001467 Shikimate kinase; Region: SKI; pfam01202 1274814001468 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1274814001469 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1274814001470 putative NAD(P) binding site [chemical binding]; other site 1274814001471 putative substrate binding site [chemical binding]; other site 1274814001472 catalytic Zn binding site [ion binding]; other site 1274814001473 structural Zn binding site [ion binding]; other site 1274814001474 dimer interface [polypeptide binding]; other site 1274814001475 integrase; Provisional; Region: PRK09692 1274814001476 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1274814001477 active site 1274814001478 Int/Topo IB signature motif; other site 1274814001479 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1274814001480 Sulfatase; Region: Sulfatase; cl17466 1274814001481 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1274814001482 Insertion element 4 transposase N-terminal; Region: Nterm_IS4; pfam13006 1274814001483 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 1274814001484 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1274814001485 putative sialic acid transporter; Provisional; Region: PRK12307 1274814001486 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814001487 putative substrate translocation pore; other site 1274814001488 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1274814001489 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1274814001490 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1274814001491 D-galactonate transporter; Region: 2A0114; TIGR00893 1274814001492 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814001493 Transposase; Region: HTH_Tnp_1; cl17663 1274814001494 Integrase core domain; Region: rve; pfam00665 1274814001495 Integrase core domain; Region: rve_3; pfam13683 1274814001496 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 1274814001497 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1274814001498 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1274814001499 Walker A/P-loop; other site 1274814001500 ATP binding site [chemical binding]; other site 1274814001501 Q-loop/lid; other site 1274814001502 ABC transporter signature motif; other site 1274814001503 Walker B; other site 1274814001504 D-loop; other site 1274814001505 H-loop/switch region; other site 1274814001506 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1274814001507 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1274814001508 ABC-ATPase subunit interface; other site 1274814001509 dimer interface [polypeptide binding]; other site 1274814001510 putative PBP binding regions; other site 1274814001511 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1274814001512 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1274814001513 dimer interface [polypeptide binding]; other site 1274814001514 ABC-ATPase subunit interface; other site 1274814001515 putative PBP binding regions; other site 1274814001516 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 1274814001517 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1274814001518 siderophore binding site; other site 1274814001519 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 1274814001520 Secretin and TonB N terminus short domain; Region: STN; smart00965 1274814001521 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1274814001522 N-terminal plug; other site 1274814001523 ligand-binding site [chemical binding]; other site 1274814001524 fec operon regulator FecR; Reviewed; Region: PRK09774 1274814001525 FecR protein; Region: FecR; pfam04773 1274814001526 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 1274814001527 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1274814001528 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1274814001529 DNA binding residues [nucleotide binding] 1274814001530 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 1274814001531 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 1274814001532 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 1274814001533 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1274814001534 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1274814001535 IS2 transposase TnpB; Reviewed; Region: PRK09409 1274814001536 HTH-like domain; Region: HTH_21; pfam13276 1274814001537 Integrase core domain; Region: rve; pfam00665 1274814001538 Integrase core domain; Region: rve_3; pfam13683 1274814001539 IS2 repressor TnpA; Reviewed; Region: PRK09413 1274814001540 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814001541 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1274814001542 Dimerization/Docking domain of Cyclic GMP-dependent Protein Kinase I; Region: DD_cGKI; cl17044 1274814001543 homodimer interface [polypeptide binding]; other site 1274814001544 putative GKAP docking site [polypeptide binding]; other site 1274814001545 Transposase C of IS166 homeodomain; Region: LZ_Tnp_IS66; pfam13007 1274814001546 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1274814001547 putative Helix-turn-helix domain of transposase IS66; Region: HTH_Tnp_IS66; pfam13005 1274814001548 Transposase IS66 family; Region: DDE_Tnp_IS66; pfam03050 1274814001549 IS66 C-terminal element; Region: DDE_Tnp_IS66_C; pfam13817 1274814001550 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3436 1274814001551 IS66 Orf2 like protein; Region: TnpB_IS66; pfam05717 1274814001552 Transposase; Region: HTH_Tnp_1; pfam01527 1274814001553 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814001554 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 1274814001555 Protein of unknown function (DUF3279); Region: DUF3279; pfam11682 1274814001556 Protein of unknown function (DUF3296); Region: DUF3296; pfam11726 1274814001557 Reverse gyrase [DNA replication, recombination, and repair]; Region: COG1110 1274814001558 Haemolysin expression modulating protein; Region: HHA; pfam05321 1274814001559 DNA replication protein [DNA replication, recombination, and repair]; Region: DnaC; COG1484 1274814001560 IstB-like ATP binding N-terminal; Region: IstB_IS21_ATP; pfam08483 1274814001561 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814001562 Walker A motif; other site 1274814001563 ATP binding site [chemical binding]; other site 1274814001564 type II restriction m6 adenine DNA methyltransferase, Alw26I/Eco31I/Esp3I family; Region: met_A_Alw26; TIGR02987 1274814001565 Eco57I restriction-modification methylase; Region: Eco57I; pfam07669 1274814001566 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1274814001567 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1274814001568 Site-specific DNA methylase [DNA replication, recombination, and repair]; Region: Dcm; COG0270 1274814001569 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1274814001570 cofactor binding site; other site 1274814001571 DNA binding site [nucleotide binding] 1274814001572 substrate interaction site [chemical binding]; other site 1274814001573 Type II restriction endonuclease (RE_Alw26IDE); Region: RE_Alw26IDE; pfam09665 1274814001574 type II restriction endonuclease, Alw26I/Eco31I/Esp3I family; Region: restrict_Alw26I; TIGR02986 1274814001575 McrBC 5-methylcytosine restriction system component; Region: McrBC; pfam10117 1274814001576 AAA domain (dynein-related subfamily); Region: AAA_5; pfam07728 1274814001577 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1274814001578 active site 1274814001579 methylthioribose kinase; Reviewed; Region: mtnK; PRK09550 1274814001580 Phosphotransferase enzyme family; Region: APH; pfam01636 1274814001581 methylthioribose-1-phosphate isomerase; Reviewed; Region: mtnA; PRK05720 1274814001582 S-methyl-5-thioribose-1-phosphate isomerase; Region: salvage_mtnA; TIGR00512 1274814001583 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cl00214 1274814001584 intersubunit interface [polypeptide binding]; other site 1274814001585 active site 1274814001586 Zn2+ binding site [ion binding]; other site 1274814001587 Putative glucose uptake permease [Carbohydrate transport and metabolism]; Region: GlcU; COG4975 1274814001588 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 1274814001589 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1274814001590 DNA binding residues [nucleotide binding] 1274814001591 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1274814001592 gluconate transporter; Region: gntP; TIGR00791 1274814001593 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1274814001594 putative dehydratase; Provisional; Region: PRK08211 1274814001595 Dehydratase family; Region: ILVD_EDD; cl00340 1274814001596 Dihydrodipicolinate synthase/N-acetylneuraminate lyase [Amino acid transport and metabolism / Cell envelope biogenesis, outer membrane]; Region: DapA; COG0329 1274814001597 Dihydrodipicolinate synthase family; Region: DHDPS-like; cd00408 1274814001598 inhibitor site; inhibition site 1274814001599 active site 1274814001600 dimer interface [polypeptide binding]; other site 1274814001601 catalytic residue [active] 1274814001602 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1274814001603 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1274814001604 Bacterial transcriptional regulator; Region: IclR; pfam01614 1274814001605 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1274814001606 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1274814001607 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1274814001608 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 1274814001609 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1274814001610 substrate binding site [chemical binding]; other site 1274814001611 hexamer interface [polypeptide binding]; other site 1274814001612 metal binding site [ion binding]; metal-binding site 1274814001613 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1274814001614 active site 1274814001615 phosphorylation site [posttranslational modification] 1274814001616 membrane complex biogenesis protein, BtpA family; Region: thylakoid_BtpA; TIGR00259 1274814001617 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1274814001618 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 1274814001619 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1274814001620 active site 1274814001621 P-loop; other site 1274814001622 phosphorylation site [posttranslational modification] 1274814001623 Cellulase M and related proteins [Carbohydrate transport and metabolism]; Region: FrvX; COG1363 1274814001624 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 1274814001625 oligomer interface [polypeptide binding]; other site 1274814001626 active site 1274814001627 metal binding site [ion binding]; metal-binding site 1274814001628 Putative zinc ribbon domain; Region: Zn_ribbon_2; pfam12674 1274814001629 SAM-dependent methyltransferases [Secondary metabolites biosynthesis, transport, and catabolism / General function prediction only]; Region: SmtA; COG0500 1274814001630 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814001631 S-adenosylmethionine binding site [chemical binding]; other site 1274814001632 ribosomal-protein-alanine acetyltransferase; Region: rimI; TIGR01575 1274814001633 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814001634 Coenzyme A binding pocket [chemical binding]; other site 1274814001635 hypothetical protein; Provisional; Region: PRK13687 1274814001636 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1274814001637 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1274814001638 Superfamily I DNA and RNA helicases and helicase subunits [DNA replication, recombination, and repair]; Region: COG1112 1274814001639 AAA domain; Region: AAA_12; pfam13087 1274814001640 C-terminal domain of Escherichia coli uncharacterized protein yjhR and similar proteins; Region: PLDc_yjhR_C_like; cd09118 1274814001641 putative active site [active] 1274814001642 catalytic site [active] 1274814001643 Domain of unknown function (DUF303); Region: DUF303; pfam03629 1274814001644 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 1274814001645 Kelch motif; Region: Kelch_1; pfam01344 1274814001646 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1274814001647 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 1274814001648 Int/Topo IB signature motif; other site 1274814001649 FimB and FimE and related proteins, DNA breaking-rejoining enzymes, integrase/recombinases, catalytic domain. This CD includes those proteins similar to E.coli FimE and FimB regulatory proteins and Proteus mirabilis MrpI; Region: INT_FimBE_C; cd01197 1274814001650 Int/Topo IB signature motif; other site 1274814001651 Fimbrial protein; Region: Fimbrial; cl01416 1274814001652 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1274814001653 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1274814001654 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1274814001655 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1274814001656 outer membrane usher protein; Provisional; Region: PRK15193 1274814001657 PapC N-terminal domain; Region: PapC_N; pfam13954 1274814001658 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1274814001659 PapC C-terminal domain; Region: PapC_C; pfam13953 1274814001660 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1274814001661 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1274814001662 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 1274814001663 mannosyl binding site [chemical binding]; other site 1274814001664 Fimbrial protein; Region: Fimbrial; pfam00419 1274814001665 fructuronate transporter; Provisional; Region: PRK10034 1274814001666 gluconate transporter; Region: gntP; TIGR00791 1274814001667 mannonate dehydratase; Region: uxuA; TIGR00695 1274814001668 mannonate dehydratase; Provisional; Region: PRK03906 1274814001669 D-mannonate oxidoreductase; Provisional; Region: PRK15037 1274814001670 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1274814001671 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1274814001672 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 1274814001673 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814001674 DNA-binding site [nucleotide binding]; DNA binding site 1274814001675 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1274814001676 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 1274814001677 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 1274814001678 cell density-dependent motility repressor; Provisional; Region: PRK10082 1274814001679 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814001680 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1274814001681 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 1274814001682 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 1274814001683 dimer interface [polypeptide binding]; other site 1274814001684 active site 1274814001685 hypothetical protein; Provisional; Region: PRK10519 1274814001686 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 1274814001687 Nucleoside recognition; Region: Gate; pfam07670 1274814001688 RNA:NAD 2'-phosphotransferase [Translation, ribosomal structure and biogenesis]; Region: KptA; COG1859 1274814001689 RNA 2'-phosphotransferase; Reviewed; Region: PRK00819 1274814001690 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1274814001691 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814001692 putative substrate translocation pore; other site 1274814001693 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3204 1274814001694 SdiA-regulated; Region: SdiA-regulated; cd09971 1274814001695 putative active site [active] 1274814001696 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 1274814001697 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 1274814001698 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 1274814001699 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 1274814001700 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 1274814001701 Predicted membrane protein [Function unknown]; Region: COG2733 1274814001702 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 1274814001703 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814001704 putative substrate translocation pore; other site 1274814001705 putative transposase; Provisional; Region: PRK09857 1274814001706 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1274814001707 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1274814001708 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814001709 DNA-binding site [nucleotide binding]; DNA binding site 1274814001710 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1274814001711 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814001712 homodimer interface [polypeptide binding]; other site 1274814001713 catalytic residue [active] 1274814001714 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 1274814001715 The Ntn hydrolases (N-terminal nucleophile) are a diverse superfamily of of enzymes that are activated autocatalytically via an N-terminally lcated nucleophilic amino acid. N-terminal nucleophile (NTN-) hydrolase superfamily, which contains a...; Region: Ntn_hydrolase; cl00467 1274814001716 Penicillin amidase; Region: Penicil_amidase; pfam01804 1274814001717 Penicillin G acylase (PGA) is the key enzyme in the industrial production of beta-lactam antibiotics. PGA hydrolyzes the side chain of penicillin G and related beta-lactam antibiotics releasing 6-amino penicillanic acid (6-APA), a building block in the...; Region: Ntn_PGA; cd03748 1274814001718 active site 1274814001719 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 1274814001720 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 1274814001721 P-loop, Walker A motif; other site 1274814001722 Base recognition motif; other site 1274814001723 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 1274814001724 Uncharacterized small protein [Function unknown]; Region: COG2879 1274814001725 carbon starvation protein A; Provisional; Region: PRK15015 1274814001726 Carbon starvation protein CstA; Region: CstA; pfam02554 1274814001727 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1274814001728 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 1274814001729 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 1274814001730 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 1274814001731 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 1274814001732 Cupin domain; Region: Cupin_2; pfam07883 1274814001733 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814001734 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814001735 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 1274814001736 putative substrate translocation pore; other site 1274814001737 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1274814001738 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 1274814001739 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 1274814001740 putative substrate binding pocket [chemical binding]; other site 1274814001741 trimer interface [polypeptide binding]; other site 1274814001742 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 1274814001743 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1274814001744 putative active site [active] 1274814001745 putative metal binding site [ion binding]; other site 1274814001746 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 1274814001747 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 1274814001748 NAD binding site [chemical binding]; other site 1274814001749 catalytic residues [active] 1274814001750 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 1274814001751 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305 1274814001752 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 1274814001753 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 1274814001754 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1274814001755 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1274814001756 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1274814001757 dimer interface [polypeptide binding]; other site 1274814001758 ligand binding site [chemical binding]; other site 1274814001759 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1274814001760 dimerization interface [polypeptide binding]; other site 1274814001761 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1274814001762 dimer interface [polypeptide binding]; other site 1274814001763 putative CheW interface [polypeptide binding]; other site 1274814001764 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814001765 D-galactonate transporter; Region: 2A0114; TIGR00893 1274814001766 putative substrate translocation pore; other site 1274814001767 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814001768 DNA-binding site [nucleotide binding]; DNA binding site 1274814001769 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1274814001770 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 1274814001771 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1274814001772 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1274814001773 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1274814001774 putative NAD(P) binding site [chemical binding]; other site 1274814001775 catalytic Zn binding site [ion binding]; other site 1274814001776 structural Zn binding site [ion binding]; other site 1274814001777 phosphoglycerol transferase I; Provisional; Region: PRK03776 1274814001778 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 1274814001779 hypothetical protein; Provisional; Region: PRK11667 1274814001780 DNA replication protein DnaC; Validated; Region: PRK07952 1274814001781 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814001782 Walker A motif; other site 1274814001783 ATP binding site [chemical binding]; other site 1274814001784 Walker B motif; other site 1274814001785 primosomal protein DnaI; Provisional; Region: PRK02854 1274814001786 hypothetical protein; Provisional; Region: PRK09917 1274814001787 Uncharacterized conserved protein [Function unknown]; Region: COG2966 1274814001788 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 1274814001789 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1274814001790 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814001791 DNA binding residues [nucleotide binding] 1274814001792 dimerization interface [polypeptide binding]; other site 1274814001793 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 1274814001794 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814001795 DNA binding residues [nucleotide binding] 1274814001796 dimerization interface [polypeptide binding]; other site 1274814001797 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 1274814001798 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 1274814001799 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 1274814001800 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 1274814001801 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 1274814001802 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 1274814001803 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814001804 S-adenosylmethionine binding site [chemical binding]; other site 1274814001805 DNA polymerase III subunit psi; Validated; Region: PRK06856 1274814001806 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 1274814001807 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814001808 Coenzyme A binding pocket [chemical binding]; other site 1274814001809 dUMP phosphatase; Provisional; Region: PRK09449 1274814001810 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814001811 motif II; other site 1274814001812 integrase; Provisional; Region: PRK09692 1274814001813 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1274814001814 active site 1274814001815 Int/Topo IB signature motif; other site 1274814001816 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1274814001817 Active Sites [active] 1274814001818 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 1274814001819 Uncharacterized conserved protein [Function unknown]; Region: COG5532 1274814001820 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1274814001821 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1274814001822 Catalytic site [active] 1274814001823 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1274814001824 Ash protein family; Region: Phage_ASH; pfam10554 1274814001825 Helix-turn-helix domain; Region: HTH_36; pfam13730 1274814001826 PerC transcriptional activator; Region: PerC; pfam06069 1274814001827 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 1274814001828 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1274814001829 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1274814001830 KilA-N domain; Region: KilA-N; pfam04383 1274814001831 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1274814001832 Antitermination protein; Region: Antiterm; pfam03589 1274814001833 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 1274814001834 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1274814001835 Zn binding sites [ion binding]; other site 1274814001836 Antitermination protein; Region: Antiterm; pfam03589 1274814001837 Protein of unknown function (DUF754); Region: DUF754; pfam05449 1274814001838 Predicted chitinase [General function prediction only]; Region: COG3179 1274814001839 catalytic residue [active] 1274814001840 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1274814001841 KilA-N domain; Region: KilA-N; pfam04383 1274814001842 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1274814001843 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1274814001844 active site 1274814001845 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1274814001846 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1274814001847 Phage-related protein [Function unknown]; Region: COG4695 1274814001848 Phage portal protein; Region: Phage_portal; pfam04860 1274814001849 Phage head maturation protease [General function prediction only]; Region: COG3740 1274814001850 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1274814001851 Phage capsid family; Region: Phage_capsid; pfam05065 1274814001852 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1274814001853 oligomerization interface [polypeptide binding]; other site 1274814001854 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1274814001855 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 1274814001856 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 1274814001857 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1274814001858 Phage tail tube protein; Region: Tail_tube; pfam10618 1274814001859 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1274814001860 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1274814001861 Catalytic domain of glycoside hydrolase (GH) families 38 and 57, lactam utilization protein LamB/YcsF family proteins, YdjC-family proteins, and similar proteins; Region: GH38-57_N_LamB_YdjC_SF; cl17191 1274814001862 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 1274814001863 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 1274814001864 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 1274814001865 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1274814001866 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1274814001867 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 1274814001868 Phage protein GP46; Region: GP46; pfam07409 1274814001869 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1274814001870 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 1274814001871 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1274814001872 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1274814001873 IS2 transposase TnpB; Reviewed; Region: PRK09409 1274814001874 HTH-like domain; Region: HTH_21; pfam13276 1274814001875 Integrase core domain; Region: rve; pfam00665 1274814001876 Integrase core domain; Region: rve_3; pfam13683 1274814001877 IS2 repressor TnpA; Reviewed; Region: PRK09413 1274814001878 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814001879 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1274814001880 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1274814001881 catalytic residues [active] 1274814001882 catalytic nucleophile [active] 1274814001883 Presynaptic Site I dimer interface [polypeptide binding]; other site 1274814001884 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1274814001885 Synaptic Flat tetramer interface [polypeptide binding]; other site 1274814001886 Synaptic Site I dimer interface [polypeptide binding]; other site 1274814001887 Caseinolytic protease (ClpP) is an ATP-dependent protease; Region: Clp_protease_like; cl15763 1274814001888 active site 1274814001889 DinI-like family; Region: DinI; pfam06183 1274814001890 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 1274814001891 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 1274814001892 G1 box; other site 1274814001893 putative GEF interaction site [polypeptide binding]; other site 1274814001894 GTP/Mg2+ binding site [chemical binding]; other site 1274814001895 Switch I region; other site 1274814001896 G2 box; other site 1274814001897 G3 box; other site 1274814001898 Switch II region; other site 1274814001899 G4 box; other site 1274814001900 G5 box; other site 1274814001901 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 1274814001902 periplasmic protein; Provisional; Region: PRK10568 1274814001903 BON domain; Region: BON; pfam04972 1274814001904 BON domain; Region: BON; pfam04972 1274814001905 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 1274814001906 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 1274814001907 active site 1274814001908 nucleophile elbow; other site 1274814001909 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1274814001910 active site 1274814001911 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 1274814001912 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814001913 FeS/SAM binding site; other site 1274814001914 hypothetical protein; Provisional; Region: PRK10977 1274814001915 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 1274814001916 intersubunit interface [polypeptide binding]; other site 1274814001917 active site 1274814001918 catalytic residue [active] 1274814001919 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 1274814001920 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1274814001921 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1274814001922 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1274814001923 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 1274814001924 phosphopentomutase; Provisional; Region: PRK05362 1274814001925 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 1274814001926 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 1274814001927 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 1274814001928 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 1274814001929 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 1274814001930 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 1274814001931 hypothetical protein; Provisional; Region: PRK11246 1274814001932 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 1274814001933 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814001934 motif II; other site 1274814001935 DNA repair protein RadA; Region: sms; TIGR00416 1274814001936 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 1274814001937 Walker A motif/ATP binding site; other site 1274814001938 ATP binding site [chemical binding]; other site 1274814001939 Walker B motif; other site 1274814001940 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1274814001941 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814001942 non-specific DNA binding site [nucleotide binding]; other site 1274814001943 salt bridge; other site 1274814001944 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 1274814001945 sequence-specific DNA binding site [nucleotide binding]; other site 1274814001946 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 1274814001947 active site 1274814001948 (T/H)XGH motif; other site 1274814001949 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 1274814001950 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 1274814001951 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814001952 Walker A/P-loop; other site 1274814001953 ATP binding site [chemical binding]; other site 1274814001954 Q-loop/lid; other site 1274814001955 ABC transporter signature motif; other site 1274814001956 Walker B; other site 1274814001957 D-loop; other site 1274814001958 H-loop/switch region; other site 1274814001959 ABC transporter; Region: ABC_tran_2; pfam12848 1274814001960 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1274814001961 lytic murein transglycosylase; Provisional; Region: PRK11619 1274814001962 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1274814001963 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1274814001964 catalytic residue [active] 1274814001965 Trp operon repressor; Provisional; Region: PRK01381 1274814001966 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 1274814001967 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1274814001968 catalytic core [active] 1274814001969 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1274814001970 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814001971 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 1274814001972 hypothetical protein; Provisional; Region: PRK10756 1274814001973 CreA protein; Region: CreA; pfam05981 1274814001974 DNA-binding response regulator CreB; Provisional; Region: PRK11083 1274814001975 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814001976 active site 1274814001977 phosphorylation site [posttranslational modification] 1274814001978 intermolecular recognition site; other site 1274814001979 dimerization interface [polypeptide binding]; other site 1274814001980 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814001981 DNA binding site [nucleotide binding] 1274814001982 sensory histidine kinase CreC; Provisional; Region: PRK11100 1274814001983 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1274814001984 dimerization interface [polypeptide binding]; other site 1274814001985 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814001986 dimer interface [polypeptide binding]; other site 1274814001987 phosphorylation site [posttranslational modification] 1274814001988 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814001989 ATP binding site [chemical binding]; other site 1274814001990 Mg2+ binding site [ion binding]; other site 1274814001991 G-X-G motif; other site 1274814001992 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 1274814001993 two-component response regulator; Provisional; Region: PRK11173 1274814001994 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814001995 active site 1274814001996 phosphorylation site [posttranslational modification] 1274814001997 intermolecular recognition site; other site 1274814001998 dimerization interface [polypeptide binding]; other site 1274814001999 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814002000 DNA binding site [nucleotide binding] 1274814002001 putative RNA methyltransferase; Provisional; Region: PRK10433 1274814002002 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 1274814002003 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 1274814002004 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 1274814002005 putative catalytic residues [active] 1274814002006 putative nucleotide binding site [chemical binding]; other site 1274814002007 putative aspartate binding site [chemical binding]; other site 1274814002008 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 1274814002009 dimer interface [polypeptide binding]; other site 1274814002010 putative threonine allosteric regulatory site; other site 1274814002011 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 1274814002012 putative threonine allosteric regulatory site; other site 1274814002013 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 1274814002014 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 1274814002015 homoserine kinase; Region: thrB; TIGR00191 1274814002016 Protein of unknown function; Region: YhfT; pfam10797 1274814002017 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1274814002018 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 1274814002019 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 1274814002020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814002021 catalytic residue [active] 1274814002022 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1274814002023 hypothetical protein; Validated; Region: PRK02101 1274814002024 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 1274814002025 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 1274814002026 transaldolase-like protein; Provisional; Region: PTZ00411 1274814002027 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1274814002028 active site 1274814002029 dimer interface [polypeptide binding]; other site 1274814002030 catalytic residue [active] 1274814002031 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1274814002032 MPT binding site; other site 1274814002033 trimer interface [polypeptide binding]; other site 1274814002034 hypothetical protein; Provisional; Region: PRK10659 1274814002035 hypothetical protein; Provisional; Region: PRK10236 1274814002036 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 1274814002037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 1274814002038 hypothetical protein; Provisional; Region: PRK10154 1274814002039 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 1274814002040 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 1274814002041 nucleotide binding site [chemical binding]; other site 1274814002042 NEF interaction site [polypeptide binding]; other site 1274814002043 SBD interface [polypeptide binding]; other site 1274814002044 chaperone protein DnaJ; Provisional; Region: PRK10767 1274814002045 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1274814002046 HSP70 interaction site [polypeptide binding]; other site 1274814002047 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 1274814002048 substrate binding site [polypeptide binding]; other site 1274814002049 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1274814002050 Zn binding sites [ion binding]; other site 1274814002051 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1274814002052 dimer interface [polypeptide binding]; other site 1274814002053 Hok/gef family; Region: HOK_GEF; pfam01848 1274814002054 D-Ala-D-Ala carboxypeptidase 3 (S13) family; Region: Peptidase_S13; cl17429 1274814002055 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 1274814002056 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 1274814002057 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814002058 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 1274814002059 putative dimerization interface [polypeptide binding]; other site 1274814002060 potential frameshift: common BLAST hit: gi|387610498|ref|YP_006113614.1| putative fimbrial biogenesis outer membrane usher protein 1274814002061 Cys-rich peptide radical SAM maturase CcpM; Region: rSAM_ocin_clost; TIGR04068 1274814002062 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 1274814002063 Protein of unknown function (DUF2575); Region: DUF2575; pfam10837 1274814002064 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 1274814002065 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 1274814002066 active site 1274814002067 Riboflavin kinase; Region: Flavokinase; smart00904 1274814002068 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 1274814002069 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1274814002070 HIGH motif; other site 1274814002071 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 1274814002072 active site 1274814002073 KMSKS motif; other site 1274814002074 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 1274814002075 tRNA binding surface [nucleotide binding]; other site 1274814002076 anticodon binding site; other site 1274814002077 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1274814002078 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 1274814002079 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1274814002080 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1274814002081 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 1274814002082 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 1274814002083 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1274814002084 active site 1274814002085 tetramer interface [polypeptide binding]; other site 1274814002086 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 1274814002087 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 1274814002088 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 1274814002089 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 1274814002090 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 1274814002091 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 1274814002092 catalytic site [active] 1274814002093 subunit interface [polypeptide binding]; other site 1274814002094 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 1274814002095 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1274814002096 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1274814002097 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 1274814002098 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1274814002099 ATP-grasp domain; Region: ATP-grasp_4; cl17255 1274814002100 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 1274814002101 IMP binding site; other site 1274814002102 dimer interface [polypeptide binding]; other site 1274814002103 interdomain contacts; other site 1274814002104 partial ornithine binding site; other site 1274814002105 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 1274814002106 carnitine operon protein CaiE; Provisional; Region: PRK13627 1274814002107 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1274814002108 putative trimer interface [polypeptide binding]; other site 1274814002109 putative metal binding site [ion binding]; other site 1274814002110 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 1274814002111 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1274814002112 substrate binding site [chemical binding]; other site 1274814002113 oxyanion hole (OAH) forming residues; other site 1274814002114 trimer interface [polypeptide binding]; other site 1274814002115 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 1274814002116 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 1274814002117 acyl-activating enzyme (AAE) consensus motif; other site 1274814002118 putative AMP binding site [chemical binding]; other site 1274814002119 putative active site [active] 1274814002120 putative CoA binding site [chemical binding]; other site 1274814002121 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 1274814002122 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1274814002123 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 1274814002124 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1274814002125 active site 1274814002126 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 1274814002127 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1274814002128 Ligand binding site [chemical binding]; other site 1274814002129 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1274814002130 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 1274814002131 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 1274814002132 Ligand binding site [chemical binding]; other site 1274814002133 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1274814002134 putative oxidoreductase FixC; Provisional; Region: PRK10157 1274814002135 ferredoxin-like protein FixX; Provisional; Region: PRK15449 1274814002136 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814002137 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 1274814002138 putative substrate translocation pore; other site 1274814002139 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 1274814002140 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 1274814002141 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1274814002142 TrkA-N domain; Region: TrkA_N; pfam02254 1274814002143 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 1274814002144 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 1274814002145 folate binding site [chemical binding]; other site 1274814002146 NADP+ binding site [chemical binding]; other site 1274814002147 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 1274814002148 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 1274814002149 active site 1274814002150 metal binding site [ion binding]; metal-binding site 1274814002151 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 1274814002152 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 1274814002153 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 1274814002154 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 1274814002155 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 1274814002156 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 1274814002157 SurA N-terminal domain; Region: SurA_N; pfam09312 1274814002158 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1274814002159 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 1274814002160 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 1274814002161 OstA-like protein; Region: OstA; pfam03968 1274814002162 Organic solvent tolerance protein; Region: OstA_C; pfam04453 1274814002163 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1274814002164 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 1274814002165 putative metal binding site [ion binding]; other site 1274814002166 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1274814002167 HSP70 interaction site [polypeptide binding]; other site 1274814002168 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1274814002169 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1274814002170 active site 1274814002171 ATP-dependent helicase HepA; Validated; Region: PRK04914 1274814002172 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1274814002173 ATP binding site [chemical binding]; other site 1274814002174 putative Mg++ binding site [ion binding]; other site 1274814002175 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1274814002176 nucleotide binding region [chemical binding]; other site 1274814002177 ATP-binding site [chemical binding]; other site 1274814002178 DNA polymerase II; Reviewed; Region: PRK05762 1274814002179 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 1274814002180 active site 1274814002181 catalytic site [active] 1274814002182 substrate binding site [chemical binding]; other site 1274814002183 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 1274814002184 active site 1274814002185 metal-binding site 1274814002186 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1274814002187 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1274814002188 intersubunit interface [polypeptide binding]; other site 1274814002189 active site 1274814002190 Zn2+ binding site [ion binding]; other site 1274814002191 L-arabinose isomerase; Provisional; Region: PRK02929 1274814002192 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 1274814002193 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 1274814002194 trimer interface [polypeptide binding]; other site 1274814002195 putative substrate binding site [chemical binding]; other site 1274814002196 putative metal binding site [ion binding]; other site 1274814002197 ribulokinase; Provisional; Region: PRK04123 1274814002198 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 1274814002199 N- and C-terminal domain interface [polypeptide binding]; other site 1274814002200 active site 1274814002201 MgATP binding site [chemical binding]; other site 1274814002202 catalytic site [active] 1274814002203 metal binding site [ion binding]; metal-binding site 1274814002204 carbohydrate binding site [chemical binding]; other site 1274814002205 homodimer interface [polypeptide binding]; other site 1274814002206 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 1274814002207 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1274814002208 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814002209 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814002210 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1274814002211 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1274814002212 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 1274814002213 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 1274814002214 Walker A/P-loop; other site 1274814002215 ATP binding site [chemical binding]; other site 1274814002216 Q-loop/lid; other site 1274814002217 ABC transporter signature motif; other site 1274814002218 Walker B; other site 1274814002219 D-loop; other site 1274814002220 H-loop/switch region; other site 1274814002221 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 1274814002222 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814002223 dimer interface [polypeptide binding]; other site 1274814002224 conserved gate region; other site 1274814002225 putative PBP binding loops; other site 1274814002226 ABC-ATPase subunit interface; other site 1274814002227 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814002228 dimer interface [polypeptide binding]; other site 1274814002229 conserved gate region; other site 1274814002230 putative PBP binding loops; other site 1274814002231 ABC-ATPase subunit interface; other site 1274814002232 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 1274814002233 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 1274814002234 transcriptional regulator SgrR; Provisional; Region: PRK13626 1274814002235 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1274814002236 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 1274814002237 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814002238 sugar efflux transporter; Region: 2A0120; TIGR00899 1274814002239 putative substrate translocation pore; other site 1274814002240 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 1274814002241 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 1274814002242 substrate binding site [chemical binding]; other site 1274814002243 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 1274814002244 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 1274814002245 substrate binding site [chemical binding]; other site 1274814002246 ligand binding site [chemical binding]; other site 1274814002247 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 1274814002248 tartrate dehydrogenase; Region: TTC; TIGR02089 1274814002249 2-isopropylmalate synthase; Validated; Region: PRK00915 1274814002250 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 1274814002251 active site 1274814002252 catalytic residues [active] 1274814002253 metal binding site [ion binding]; metal-binding site 1274814002254 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 1274814002255 leu operon leader peptide; Provisional; Region: PRK09925 1274814002256 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 1274814002257 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814002258 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 1274814002259 putative substrate binding pocket [chemical binding]; other site 1274814002260 putative dimerization interface [polypeptide binding]; other site 1274814002261 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 1274814002262 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1274814002263 PYR/PP interface [polypeptide binding]; other site 1274814002264 dimer interface [polypeptide binding]; other site 1274814002265 TPP binding site [chemical binding]; other site 1274814002266 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1274814002267 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1274814002268 TPP-binding site [chemical binding]; other site 1274814002269 dimer interface [polypeptide binding]; other site 1274814002270 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 1274814002271 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1274814002272 putative valine binding site [chemical binding]; other site 1274814002273 dimer interface [polypeptide binding]; other site 1274814002274 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 1274814002275 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 1274814002276 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814002277 DNA binding site [nucleotide binding] 1274814002278 domain linker motif; other site 1274814002279 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 1274814002280 dimerization interface [polypeptide binding]; other site 1274814002281 ligand binding site [chemical binding]; other site 1274814002282 mraZ protein; Region: TIGR00242 1274814002283 MraZ protein; Region: MraZ; pfam02381 1274814002284 MraZ protein; Region: MraZ; pfam02381 1274814002285 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 1274814002286 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 1274814002287 cell division protein FtsL; Provisional; Region: PRK10772 1274814002288 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 1274814002289 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1274814002290 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1274814002291 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 1274814002292 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1274814002293 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1274814002294 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1274814002295 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 1274814002296 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1274814002297 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1274814002298 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1274814002299 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 1274814002300 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 1274814002301 Mg++ binding site [ion binding]; other site 1274814002302 putative catalytic motif [active] 1274814002303 putative substrate binding site [chemical binding]; other site 1274814002304 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 1274814002305 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1274814002306 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1274814002307 cell division protein FtsW; Provisional; Region: PRK10774 1274814002308 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 1274814002309 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 1274814002310 active site 1274814002311 homodimer interface [polypeptide binding]; other site 1274814002312 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 1274814002313 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 1274814002314 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1274814002315 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1274814002316 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 1274814002317 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1274814002318 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1274814002319 cell division protein FtsQ; Provisional; Region: PRK10775 1274814002320 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 1274814002321 Cell division protein FtsQ; Region: FtsQ; pfam03799 1274814002322 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 1274814002323 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1274814002324 Cell division protein FtsA; Region: FtsA; pfam14450 1274814002325 cell division protein FtsZ; Validated; Region: PRK09330 1274814002326 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 1274814002327 nucleotide binding site [chemical binding]; other site 1274814002328 SulA interaction site; other site 1274814002329 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 1274814002330 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 1274814002331 SecA regulator SecM; Provisional; Region: PRK02943 1274814002332 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 1274814002333 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 1274814002334 SEC-C motif; Region: SEC-C; pfam02810 1274814002335 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1274814002336 active site 1274814002337 8-oxo-dGMP binding site [chemical binding]; other site 1274814002338 nudix motif; other site 1274814002339 metal binding site [ion binding]; metal-binding site 1274814002340 DNA gyrase inhibitor; Reviewed; Region: PRK00418 1274814002341 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 1274814002342 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 1274814002343 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 1274814002344 CoA-binding site [chemical binding]; other site 1274814002345 ATP-binding [chemical binding]; other site 1274814002346 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 1274814002347 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1274814002348 active site 1274814002349 type IV pilin biogenesis protein; Provisional; Region: PRK10573 1274814002350 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1274814002351 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1274814002352 hypothetical protein; Provisional; Region: PRK10436 1274814002353 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1274814002354 Walker A motif; other site 1274814002355 ATP binding site [chemical binding]; other site 1274814002356 Walker B motif; other site 1274814002357 putative major pilin subunit; Provisional; Region: PRK10574 1274814002358 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1274814002359 Pilin (bacterial filament); Region: Pilin; pfam00114 1274814002360 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 1274814002361 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 1274814002362 dimerization interface [polypeptide binding]; other site 1274814002363 active site 1274814002364 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1274814002365 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1274814002366 amidase catalytic site [active] 1274814002367 Zn binding residues [ion binding]; other site 1274814002368 substrate binding site [chemical binding]; other site 1274814002369 regulatory protein AmpE; Provisional; Region: PRK10987 1274814002370 aromatic amino acid transporter; Provisional; Region: PRK10238 1274814002371 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1274814002372 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814002373 DNA-binding site [nucleotide binding]; DNA binding site 1274814002374 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1274814002375 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 1274814002376 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 1274814002377 dimer interface [polypeptide binding]; other site 1274814002378 TPP-binding site [chemical binding]; other site 1274814002379 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 1274814002380 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1274814002381 E3 interaction surface; other site 1274814002382 lipoyl attachment site [posttranslational modification]; other site 1274814002383 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1274814002384 E3 interaction surface; other site 1274814002385 lipoyl attachment site [posttranslational modification]; other site 1274814002386 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1274814002387 E3 interaction surface; other site 1274814002388 lipoyl attachment site [posttranslational modification]; other site 1274814002389 e3 binding domain; Region: E3_binding; pfam02817 1274814002390 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1274814002391 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 1274814002392 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1274814002393 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1274814002394 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1274814002395 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 1274814002396 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 1274814002397 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 1274814002398 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 1274814002399 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 1274814002400 substrate binding site [chemical binding]; other site 1274814002401 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 1274814002402 substrate binding site [chemical binding]; other site 1274814002403 ligand binding site [chemical binding]; other site 1274814002404 hypothetical protein; Provisional; Region: PRK05248 1274814002405 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 1274814002406 spermidine synthase; Provisional; Region: PRK00811 1274814002407 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814002408 S-adenosylmethionine binding site [chemical binding]; other site 1274814002409 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 1274814002410 multicopper oxidase; Provisional; Region: PRK10965 1274814002411 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1274814002412 Multicopper oxidase; Region: Cu-oxidase; pfam00394 1274814002413 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1274814002414 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 1274814002415 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 1274814002416 Trp docking motif [polypeptide binding]; other site 1274814002417 putative active site [active] 1274814002418 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1274814002419 active site 1274814002420 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 1274814002421 active site clefts [active] 1274814002422 zinc binding site [ion binding]; other site 1274814002423 dimer interface [polypeptide binding]; other site 1274814002424 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1274814002425 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1274814002426 Walker A/P-loop; other site 1274814002427 ATP binding site [chemical binding]; other site 1274814002428 Q-loop/lid; other site 1274814002429 ABC transporter signature motif; other site 1274814002430 Walker B; other site 1274814002431 D-loop; other site 1274814002432 H-loop/switch region; other site 1274814002433 inner membrane transport permease; Provisional; Region: PRK15066 1274814002434 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1274814002435 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1274814002436 active pocket/dimerization site; other site 1274814002437 active site 1274814002438 phosphorylation site [posttranslational modification] 1274814002439 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 1274814002440 putative active site [active] 1274814002441 putative metal binding site [ion binding]; other site 1274814002442 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 1274814002443 tetramerization interface [polypeptide binding]; other site 1274814002444 active site 1274814002445 Uncharacterized conserved protein [Function unknown]; Region: COG5464 1274814002446 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1274814002447 pantoate--beta-alanine ligase; Region: panC; TIGR00018 1274814002448 Pantoate-beta-alanine ligase; Region: PanC; cd00560 1274814002449 active site 1274814002450 ATP-binding site [chemical binding]; other site 1274814002451 pantoate-binding site; other site 1274814002452 HXXH motif; other site 1274814002453 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 1274814002454 oligomerization interface [polypeptide binding]; other site 1274814002455 active site 1274814002456 metal binding site [ion binding]; metal-binding site 1274814002457 putative fimbrial-like adhesin protein; Provisional; Region: PRK09723 1274814002458 putative fimbrial protein StaF; Provisional; Region: PRK15262 1274814002459 putative fimbrial protein StaE; Provisional; Region: PRK15263 1274814002460 Fimbrial protein; Region: Fimbrial; cl01416 1274814002461 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 1274814002462 PapC N-terminal domain; Region: PapC_N; pfam13954 1274814002463 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1274814002464 PapC C-terminal domain; Region: PapC_C; pfam13953 1274814002465 putative chaperone protein EcpD; Provisional; Region: PRK09926 1274814002466 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1274814002467 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1274814002468 Fimbrial protein; Region: Fimbrial; cl01416 1274814002469 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 1274814002470 catalytic center binding site [active] 1274814002471 ATP binding site [chemical binding]; other site 1274814002472 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 1274814002473 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1274814002474 active site 1274814002475 NTP binding site [chemical binding]; other site 1274814002476 metal binding triad [ion binding]; metal-binding site 1274814002477 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1274814002478 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 1274814002479 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 1274814002480 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 1274814002481 active site 1274814002482 nucleotide binding site [chemical binding]; other site 1274814002483 HIGH motif; other site 1274814002484 KMSKS motif; other site 1274814002485 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 1274814002486 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 1274814002487 2'-5' RNA ligase; Provisional; Region: PRK15124 1274814002488 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1274814002489 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 1274814002490 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 1274814002491 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1274814002492 ATP binding site [chemical binding]; other site 1274814002493 putative Mg++ binding site [ion binding]; other site 1274814002494 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1274814002495 nucleotide binding region [chemical binding]; other site 1274814002496 ATP-binding site [chemical binding]; other site 1274814002497 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 1274814002498 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 1274814002499 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 1274814002500 Transglycosylase; Region: Transgly; pfam00912 1274814002501 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1274814002502 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 1274814002503 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1274814002504 N-terminal plug; other site 1274814002505 ligand-binding site [chemical binding]; other site 1274814002506 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 1274814002507 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1274814002508 Walker A/P-loop; other site 1274814002509 ATP binding site [chemical binding]; other site 1274814002510 Q-loop/lid; other site 1274814002511 ABC transporter signature motif; other site 1274814002512 Walker B; other site 1274814002513 D-loop; other site 1274814002514 H-loop/switch region; other site 1274814002515 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1274814002516 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 1274814002517 siderophore binding site; other site 1274814002518 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1274814002519 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1274814002520 ABC-ATPase subunit interface; other site 1274814002521 dimer interface [polypeptide binding]; other site 1274814002522 putative PBP binding regions; other site 1274814002523 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1274814002524 ABC-ATPase subunit interface; other site 1274814002525 dimer interface [polypeptide binding]; other site 1274814002526 putative PBP binding regions; other site 1274814002527 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 1274814002528 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1274814002529 inhibitor-cofactor binding pocket; inhibition site 1274814002530 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814002531 catalytic residue [active] 1274814002532 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1274814002533 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 1274814002534 Cl- selectivity filter; other site 1274814002535 Cl- binding residues [ion binding]; other site 1274814002536 pore gating glutamate residue; other site 1274814002537 dimer interface [polypeptide binding]; other site 1274814002538 H+/Cl- coupling transport residue; other site 1274814002539 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 1274814002540 hypothetical protein; Provisional; Region: PRK10578 1274814002541 UPF0126 domain; Region: UPF0126; pfam03458 1274814002542 UPF0126 domain; Region: UPF0126; pfam03458 1274814002543 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 1274814002544 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 1274814002545 cobalamin binding residues [chemical binding]; other site 1274814002546 putative BtuC binding residues; other site 1274814002547 dimer interface [polypeptide binding]; other site 1274814002548 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 1274814002549 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 1274814002550 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 1274814002551 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1274814002552 Zn2+ binding site [ion binding]; other site 1274814002553 Mg2+ binding site [ion binding]; other site 1274814002554 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 1274814002555 serine endoprotease; Provisional; Region: PRK10942 1274814002556 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1274814002557 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1274814002558 protein binding site [polypeptide binding]; other site 1274814002559 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1274814002560 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 1274814002561 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 1274814002562 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 1274814002563 hypothetical protein; Provisional; Region: PRK13677 1274814002564 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 1274814002565 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 1274814002566 trimer interface [polypeptide binding]; other site 1274814002567 active site 1274814002568 substrate binding site [chemical binding]; other site 1274814002569 CoA binding site [chemical binding]; other site 1274814002570 PII uridylyl-transferase; Provisional; Region: PRK05007 1274814002571 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1274814002572 metal binding triad; other site 1274814002573 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1274814002574 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1274814002575 Zn2+ binding site [ion binding]; other site 1274814002576 Mg2+ binding site [ion binding]; other site 1274814002577 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 1274814002578 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 1274814002579 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 1274814002580 active site 1274814002581 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 1274814002582 rRNA interaction site [nucleotide binding]; other site 1274814002583 S8 interaction site; other site 1274814002584 putative laminin-1 binding site; other site 1274814002585 elongation factor Ts; Provisional; Region: tsf; PRK09377 1274814002586 UBA/TS-N domain; Region: UBA; pfam00627 1274814002587 Elongation factor TS; Region: EF_TS; pfam00889 1274814002588 Elongation factor TS; Region: EF_TS; pfam00889 1274814002589 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 1274814002590 putative nucleotide binding site [chemical binding]; other site 1274814002591 uridine monophosphate binding site [chemical binding]; other site 1274814002592 homohexameric interface [polypeptide binding]; other site 1274814002593 ribosome recycling factor; Reviewed; Region: frr; PRK00083 1274814002594 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 1274814002595 hinge region; other site 1274814002596 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 1274814002597 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 1274814002598 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 1274814002599 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 1274814002600 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 1274814002601 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 1274814002602 catalytic residue [active] 1274814002603 putative FPP diphosphate binding site; other site 1274814002604 putative FPP binding hydrophobic cleft; other site 1274814002605 dimer interface [polypeptide binding]; other site 1274814002606 putative IPP diphosphate binding site; other site 1274814002607 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 1274814002608 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1274814002609 zinc metallopeptidase RseP; Provisional; Region: PRK10779 1274814002610 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1274814002611 active site 1274814002612 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 1274814002613 protein binding site [polypeptide binding]; other site 1274814002614 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 1274814002615 putative substrate binding region [chemical binding]; other site 1274814002616 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 1274814002617 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1274814002618 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1274814002619 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1274814002620 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1274814002621 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 1274814002622 Surface antigen; Region: Bac_surface_Ag; pfam01103 1274814002623 periplasmic chaperone; Provisional; Region: PRK10780 1274814002624 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 1274814002625 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 1274814002626 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 1274814002627 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 1274814002628 trimer interface [polypeptide binding]; other site 1274814002629 active site 1274814002630 UDP-GlcNAc binding site [chemical binding]; other site 1274814002631 lipid binding site [chemical binding]; lipid-binding site 1274814002632 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 1274814002633 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 1274814002634 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 1274814002635 active site 1274814002636 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 1274814002637 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 1274814002638 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 1274814002639 RNA/DNA hybrid binding site [nucleotide binding]; other site 1274814002640 active site 1274814002641 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 1274814002642 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 1274814002643 putative active site [active] 1274814002644 putative PHP Thumb interface [polypeptide binding]; other site 1274814002645 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 1274814002646 generic binding surface II; other site 1274814002647 generic binding surface I; other site 1274814002648 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 1274814002649 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 1274814002650 lysine decarboxylase LdcC; Provisional; Region: PRK15399 1274814002651 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1274814002652 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1274814002653 homodimer interface [polypeptide binding]; other site 1274814002654 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814002655 catalytic residue [active] 1274814002656 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1274814002657 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 1274814002658 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1274814002659 putative metal binding site [ion binding]; other site 1274814002660 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 1274814002661 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 1274814002662 Ligand Binding Site [chemical binding]; other site 1274814002663 TilS substrate binding domain; Region: TilS; pfam09179 1274814002664 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 1274814002665 Rho-binding antiterminator; Provisional; Region: PRK11625 1274814002666 hypothetical protein; Provisional; Region: PRK04964 1274814002667 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 1274814002668 hypothetical protein; Provisional; Region: PRK09256 1274814002669 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 1274814002670 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 1274814002671 NlpE N-terminal domain; Region: NlpE; pfam04170 1274814002672 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814002673 hypothetical protein; Provisional; Region: PRK11479 1274814002674 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 1274814002675 prolyl-tRNA synthetase; Provisional; Region: PRK09194 1274814002676 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 1274814002677 dimer interface [polypeptide binding]; other site 1274814002678 motif 1; other site 1274814002679 active site 1274814002680 motif 2; other site 1274814002681 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 1274814002682 putative deacylase active site [active] 1274814002683 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 1274814002684 active site 1274814002685 motif 3; other site 1274814002686 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 1274814002687 anticodon binding site; other site 1274814002688 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 1274814002689 homodimer interaction site [polypeptide binding]; other site 1274814002690 cofactor binding site; other site 1274814002691 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 1274814002692 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 1274814002693 lipoprotein, YaeC family; Region: TIGR00363 1274814002694 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814002695 dimer interface [polypeptide binding]; other site 1274814002696 conserved gate region; other site 1274814002697 ABC-ATPase subunit interface; other site 1274814002698 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 1274814002699 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 1274814002700 Walker A/P-loop; other site 1274814002701 ATP binding site [chemical binding]; other site 1274814002702 Q-loop/lid; other site 1274814002703 ABC transporter signature motif; other site 1274814002704 Walker B; other site 1274814002705 D-loop; other site 1274814002706 H-loop/switch region; other site 1274814002707 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 1274814002708 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 1274814002709 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814002710 active site 1274814002711 motif I; other site 1274814002712 motif II; other site 1274814002713 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1274814002714 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1274814002715 active site 1274814002716 catalytic tetrad [active] 1274814002717 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1274814002718 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814002719 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 1274814002720 putative effector binding pocket; other site 1274814002721 dimerization interface [polypeptide binding]; other site 1274814002722 hypothetical protein; Provisional; Region: PRK05421 1274814002723 putative catalytic site [active] 1274814002724 putative metal binding site [ion binding]; other site 1274814002725 putative phosphate binding site [ion binding]; other site 1274814002726 putative catalytic site [active] 1274814002727 putative phosphate binding site [ion binding]; other site 1274814002728 putative metal binding site [ion binding]; other site 1274814002729 Methyltransferase domain; Region: Methyltransf_23; pfam13489 1274814002730 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814002731 S-adenosylmethionine binding site [chemical binding]; other site 1274814002732 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 1274814002733 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1274814002734 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1274814002735 catalytic residue [active] 1274814002736 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1274814002737 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1274814002738 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 1274814002739 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814002740 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 1274814002741 RNA/DNA hybrid binding site [nucleotide binding]; other site 1274814002742 active site 1274814002743 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 1274814002744 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 1274814002745 active site 1274814002746 catalytic site [active] 1274814002747 substrate binding site [chemical binding]; other site 1274814002748 type VI secretion system effector, Hcp1 family; Region: VI_effect_Hcp1; TIGR03344 1274814002749 ImpA domain protein; Region: DUF3702; pfam12486 1274814002750 RHS Repeat; Region: RHS_repeat; cl11982 1274814002751 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1274814002752 RHS Repeat; Region: RHS_repeat; pfam05593 1274814002753 RHS Repeat; Region: RHS_repeat; cl11982 1274814002754 RHS Repeat; Region: RHS_repeat; pfam05593 1274814002755 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 1274814002756 RHS protein; Region: RHS; pfam03527 1274814002757 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1274814002758 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1274814002759 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1274814002760 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1274814002761 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1274814002762 C-N hydrolase family amidase; Provisional; Region: PRK10438 1274814002763 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 1274814002764 putative active site [active] 1274814002765 catalytic triad [active] 1274814002766 dimer interface [polypeptide binding]; other site 1274814002767 multimer interface [polypeptide binding]; other site 1274814002768 C-lysozyme inhibitor; Provisional; Region: PRK09993 1274814002769 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 1274814002770 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 1274814002771 active site 1274814002772 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 1274814002773 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1274814002774 dimer interface [polypeptide binding]; other site 1274814002775 active site 1274814002776 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 1274814002777 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 1274814002778 putative active site [active] 1274814002779 putative dimer interface [polypeptide binding]; other site 1274814002780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 1274814002781 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1274814002782 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1274814002783 NlpC/P60 family; Region: NLPC_P60; pfam00877 1274814002784 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 1274814002785 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 1274814002786 FHIPEP family; Region: FHIPEP; pfam00771 1274814002787 hypothetical protein; Validated; Region: PRK06778 1274814002788 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1274814002789 ligand binding site [chemical binding]; other site 1274814002790 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 1274814002791 active site 1274814002792 DNA polymerase IV; Validated; Region: PRK02406 1274814002793 DNA binding site [nucleotide binding] 1274814002794 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1274814002795 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814002796 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cl17182 1274814002797 Coenzyme A binding pocket [chemical binding]; other site 1274814002798 Uncharacterized protein family UPF0027; Region: UPF0027; cl17455 1274814002799 RF-1 domain; Region: RF-1; cl17422 1274814002800 RF-1 domain; Region: RF-1; cl17422 1274814002801 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 1274814002802 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 1274814002803 metal binding site [ion binding]; metal-binding site 1274814002804 dimer interface [polypeptide binding]; other site 1274814002805 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1274814002806 active site 1274814002807 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 1274814002808 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 1274814002809 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1274814002810 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1274814002811 trimer interface [polypeptide binding]; other site 1274814002812 eyelet of channel; other site 1274814002813 gamma-glutamyl kinase; Provisional; Region: PRK05429 1274814002814 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 1274814002815 nucleotide binding site [chemical binding]; other site 1274814002816 homotetrameric interface [polypeptide binding]; other site 1274814002817 putative phosphate binding site [ion binding]; other site 1274814002818 putative allosteric binding site; other site 1274814002819 PUA domain; Region: PUA; pfam01472 1274814002820 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 1274814002821 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 1274814002822 putative catalytic cysteine [active] 1274814002823 integrase; Provisional; Region: int; PHA02601 1274814002824 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 1274814002825 Int/Topo IB signature motif; other site 1274814002826 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 1274814002827 Uncharacterized conserved protein [Function unknown]; Region: COG5532 1274814002828 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814002829 non-specific DNA binding site [nucleotide binding]; other site 1274814002830 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1274814002831 salt bridge; other site 1274814002832 sequence-specific DNA binding site [nucleotide binding]; other site 1274814002833 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1274814002834 Catalytic site [active] 1274814002835 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 1274814002836 Domain of unknown function (DUF4222); Region: DUF4222; pfam13973 1274814002837 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814002838 DNA-binding site [nucleotide binding]; DNA binding site 1274814002839 PerC transcriptional activator; Region: PerC; pfam06069 1274814002840 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 1274814002841 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1274814002842 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1274814002843 KilA-N domain; Region: KilA-N; pfam04383 1274814002844 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1274814002845 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1274814002846 EAP30/Vps36 family; Region: EAP30; pfam04157 1274814002847 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1274814002848 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814002849 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1274814002850 DNA methylase; Region: N6_N4_Mtase; pfam01555 1274814002851 Phage holin family (Lysis protein S); Region: Phage_holin_3; cl04938 1274814002852 The lysozyme from bacteriophage lambda hydrolyses the beta-1,4-glycosidic bond between N-acetylmuramic acid (MurNAc) and N-acetylglucosamine (GlcNAc), as do other lysozymes. But unlike other lysozymes, bacteriophage lambda does not produce a reducing...; Region: bacteriophage_lambda_lysozyme; cd00736 1274814002853 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1274814002854 catalytic residue [active] 1274814002855 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 1274814002856 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1274814002857 active site 1274814002858 Phage terminase, small subunit; Region: Terminase_4; pfam05119 1274814002859 Phage terminase-like protein, large subunit [General function prediction only]; Region: COG4626 1274814002860 Phage-related protein [Function unknown]; Region: COG4695 1274814002861 Phage portal protein; Region: Phage_portal; pfam04860 1274814002862 Caudovirus prohead protease; Region: Peptidase_U35; cl01521 1274814002863 phage major capsid protein, HK97 family; Region: major_cap_HK97; TIGR01554 1274814002864 Phage capsid family; Region: Phage_capsid; pfam05065 1274814002865 Head-Tail Connector Protein gp6 of Bacteriophage HK97 and similar proteins; Region: gp6; cd08054 1274814002866 oligomerization interface [polypeptide binding]; other site 1274814002867 Phage head-tail joining protein; Region: Phage_H_T_join; pfam05521 1274814002868 Protein of unknown function (DUF2635); Region: DUF2635; pfam10948 1274814002869 Mu-like prophage tail sheath protein gpL [General function prediction only]; Region: COG4386 1274814002870 Phage tail sheath protein; Region: Phage_sheath_1; pfam04984 1274814002871 Phage tail tube protein; Region: Tail_tube; pfam10618 1274814002872 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1274814002873 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1274814002874 Mu-like prophage DNA circulation protein [General function prediction only]; Region: COG4228 1274814002875 DNA circulation protein N-terminus; Region: DNA_circ_N; pfam07157 1274814002876 Mu-like prophage tail protein gpP [General function prediction only]; Region: COG4379 1274814002877 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1274814002878 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1274814002879 Bacteriophage Mu Gp45 protein; Region: Phage_Mu_Gp45; pfam06890 1274814002880 Phage protein GP46; Region: GP46; pfam07409 1274814002881 Uncharacterized homolog of phage Mu protein gp47 [Function unknown]; Region: XkdT; COG3299 1274814002882 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3778 1274814002883 Phage Tail Collar Domain; Region: Collar; pfam07484 1274814002884 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1274814002885 Phage Tail Collar Domain; Region: Collar; pfam07484 1274814002886 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1274814002887 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1274814002888 catalytic residues [active] 1274814002889 catalytic nucleophile [active] 1274814002890 Presynaptic Site I dimer interface [polypeptide binding]; other site 1274814002891 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1274814002892 Synaptic Flat tetramer interface [polypeptide binding]; other site 1274814002893 Synaptic Site I dimer interface [polypeptide binding]; other site 1274814002894 DNA binding site [nucleotide binding] 1274814002895 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1274814002896 DNA-binding interface [nucleotide binding]; DNA binding site 1274814002897 Polymerase and Histidinol Phosphatase domain; Region: PHP; cl17102 1274814002898 active site 1274814002899 AAA domain; Region: AAA_23; pfam13476 1274814002900 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814002901 ABC transporter signature motif; other site 1274814002902 Walker B; other site 1274814002903 D-loop; other site 1274814002904 H-loop/switch region; other site 1274814002905 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1274814002906 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1274814002907 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1274814002908 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1274814002909 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1274814002910 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 1274814002911 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1274814002912 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1274814002913 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 1274814002914 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 1274814002915 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 1274814002916 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1274814002917 catalytic loop [active] 1274814002918 iron binding site [ion binding]; other site 1274814002919 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1274814002920 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 1274814002921 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 1274814002922 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1274814002923 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 1274814002924 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1274814002925 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1274814002926 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814002927 DNA binding residues [nucleotide binding] 1274814002928 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 1274814002929 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 1274814002930 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1274814002931 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1274814002932 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1274814002933 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1274814002934 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1274814002935 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 1274814002936 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814002937 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 1274814002938 Predicted membrane protein [Function unknown]; Region: COG3059 1274814002939 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1274814002940 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 1274814002941 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1274814002942 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1274814002943 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1274814002944 Cupin; Region: Cupin_6; pfam12852 1274814002945 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1274814002946 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814002947 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1274814002948 Cysteine-rich domain; Region: CCG; pfam02754 1274814002949 Cysteine-rich domain; Region: CCG; pfam02754 1274814002950 iron-sulfur cluster-binding protein; Region: TIGR00273 1274814002951 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 1274814002952 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1274814002953 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 1274814002954 Uncharacterized conserved protein [Function unknown]; Region: COG1556 1274814002955 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1274814002956 choline dehydrogenase; Validated; Region: PRK02106 1274814002957 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 1274814002958 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 1274814002959 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 1274814002960 tetrameric interface [polypeptide binding]; other site 1274814002961 NAD binding site [chemical binding]; other site 1274814002962 catalytic residues [active] 1274814002963 transcriptional regulator BetI; Validated; Region: PRK00767 1274814002964 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1274814002965 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1274814002966 choline transport protein BetT; Provisional; Region: PRK09928 1274814002967 potential frameshift: common BLAST hit: gi|387620078|ref|YP_006127705.1| c-di-GMP-specific phosphodiesterase 1274814002968 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1274814002969 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814002970 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1274814002971 dimerization interface [polypeptide binding]; other site 1274814002972 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1274814002973 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1274814002974 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cl02529 1274814002975 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1274814002976 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1274814002977 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1274814002978 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 1274814002979 CoA binding domain; Region: CoA_binding; pfam02629 1274814002980 CoA-ligase; Region: Ligase_CoA; pfam00549 1274814002981 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1274814002982 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1274814002983 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1274814002984 putative substrate binding site [chemical binding]; other site 1274814002985 nucleotide binding site [chemical binding]; other site 1274814002986 nucleotide binding site [chemical binding]; other site 1274814002987 homodimer interface [polypeptide binding]; other site 1274814002988 putative deaminase; Validated; Region: PRK06846 1274814002989 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1274814002990 active site 1274814002991 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 1274814002992 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 1274814002993 putative NAD(P) binding site [chemical binding]; other site 1274814002994 putative substrate binding site [chemical binding]; other site 1274814002995 catalytic Zn binding site [ion binding]; other site 1274814002996 structural Zn binding site [ion binding]; other site 1274814002997 dimer interface [polypeptide binding]; other site 1274814002998 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 1274814002999 hypothetical protein; Provisional; Region: PRK09929 1274814003000 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 1274814003001 Propionate catabolism activator; Region: PrpR_N; pfam06506 1274814003002 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814003003 Walker A motif; other site 1274814003004 ATP binding site [chemical binding]; other site 1274814003005 Walker B motif; other site 1274814003006 arginine finger; other site 1274814003007 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1274814003008 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 1274814003009 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 1274814003010 tetramer interface [polypeptide binding]; other site 1274814003011 active site 1274814003012 Mg2+/Mn2+ binding site [ion binding]; other site 1274814003013 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1274814003014 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 1274814003015 dimer interface [polypeptide binding]; other site 1274814003016 active site 1274814003017 citrylCoA binding site [chemical binding]; other site 1274814003018 oxalacetate/citrate binding site [chemical binding]; other site 1274814003019 coenzyme A binding site [chemical binding]; other site 1274814003020 catalytic triad [active] 1274814003021 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 1274814003022 2-methylcitrate dehydratase; Region: prpD; TIGR02330 1274814003023 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 1274814003024 Adenylate forming domain, Class I; Region: AFD_class_I; cl17068 1274814003025 acyl-activating enzyme (AAE) consensus motif; other site 1274814003026 active site 1274814003027 AMP binding site [chemical binding]; other site 1274814003028 CoA binding site [chemical binding]; other site 1274814003029 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 1274814003030 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 1274814003031 Na binding site [ion binding]; other site 1274814003032 putative substrate binding site [chemical binding]; other site 1274814003033 cytosine deaminase; Provisional; Region: PRK09230 1274814003034 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 1274814003035 active site 1274814003036 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 1274814003037 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814003038 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 1274814003039 dimerization interface [polypeptide binding]; other site 1274814003040 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 1274814003041 active site clefts [active] 1274814003042 zinc binding site [ion binding]; other site 1274814003043 dimer interface [polypeptide binding]; other site 1274814003044 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 1274814003045 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 1274814003046 oligomer interface [polypeptide binding]; other site 1274814003047 active site 1274814003048 putative cyanate transporter; Provisional; Region: cynX; PRK09705 1274814003049 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814003050 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 1274814003051 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1274814003052 active site 1274814003053 substrate binding site [chemical binding]; other site 1274814003054 trimer interface [polypeptide binding]; other site 1274814003055 CoA binding site [chemical binding]; other site 1274814003056 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 1274814003057 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814003058 putative substrate translocation pore; other site 1274814003059 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 1274814003060 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1274814003061 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1274814003062 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1274814003063 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1274814003064 lac repressor; Reviewed; Region: lacI; PRK09526 1274814003065 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814003066 DNA binding site [nucleotide binding] 1274814003067 domain linker motif; other site 1274814003068 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 1274814003069 ligand binding site [chemical binding]; other site 1274814003070 dimerization interface (open form) [polypeptide binding]; other site 1274814003071 dimerization interface (closed form) [polypeptide binding]; other site 1274814003072 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 1274814003073 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1274814003074 Bacterial transcriptional regulator; Region: IclR; pfam01614 1274814003075 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 1274814003076 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1274814003077 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 1274814003078 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1274814003079 putative active site [active] 1274814003080 Fe(II) binding site [ion binding]; other site 1274814003081 putative dimer interface [polypeptide binding]; other site 1274814003082 putative tetramer interface [polypeptide binding]; other site 1274814003083 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 1274814003084 methyl indole-3-acetate methyltransferase; Region: PLN02211; cl17657 1274814003085 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 1274814003086 acetaldehyde dehydrogenase; Validated; Region: PRK08300 1274814003087 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1274814003088 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 1274814003089 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 1274814003090 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 1274814003091 active site 1274814003092 catalytic residues [active] 1274814003093 metal binding site [ion binding]; metal-binding site 1274814003094 DmpG-like communication domain; Region: DmpG_comm; pfam07836 1274814003095 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 1274814003096 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814003097 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814003098 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 1274814003099 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1274814003100 S-formylglutathione hydrolase; Region: PLN02442 1274814003101 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 1274814003102 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 1274814003103 substrate binding site [chemical binding]; other site 1274814003104 catalytic Zn binding site [ion binding]; other site 1274814003105 NAD binding site [chemical binding]; other site 1274814003106 structural Zn binding site [ion binding]; other site 1274814003107 dimer interface [polypeptide binding]; other site 1274814003108 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1274814003109 putative metal binding site [ion binding]; other site 1274814003110 putative homodimer interface [polypeptide binding]; other site 1274814003111 putative homotetramer interface [polypeptide binding]; other site 1274814003112 putative homodimer-homodimer interface [polypeptide binding]; other site 1274814003113 putative allosteric switch controlling residues; other site 1274814003114 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1274814003115 putative trimer interface [polypeptide binding]; other site 1274814003116 putative CoA binding site [chemical binding]; other site 1274814003117 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 1274814003118 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1274814003119 DXD motif; other site 1274814003120 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 1274814003121 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 1274814003122 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814003123 substrate binding pocket [chemical binding]; other site 1274814003124 membrane-bound complex binding site; other site 1274814003125 hinge residues; other site 1274814003126 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 1274814003127 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1274814003128 Walker A/P-loop; other site 1274814003129 ATP binding site [chemical binding]; other site 1274814003130 Q-loop/lid; other site 1274814003131 ABC transporter signature motif; other site 1274814003132 Walker B; other site 1274814003133 D-loop; other site 1274814003134 H-loop/switch region; other site 1274814003135 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1274814003136 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814003137 dimer interface [polypeptide binding]; other site 1274814003138 conserved gate region; other site 1274814003139 putative PBP binding loops; other site 1274814003140 ABC-ATPase subunit interface; other site 1274814003141 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 1274814003142 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 1274814003143 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 1274814003144 dimer interface [polypeptide binding]; other site 1274814003145 active site 1274814003146 Schiff base residues; other site 1274814003147 IS2 transposase TnpB; Reviewed; Region: PRK09409 1274814003148 HTH-like domain; Region: HTH_21; pfam13276 1274814003149 Integrase core domain; Region: rve; pfam00665 1274814003150 Integrase core domain; Region: rve_3; pfam13683 1274814003151 IS2 repressor TnpA; Reviewed; Region: PRK09413 1274814003152 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814003153 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 1274814003154 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1274814003155 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1274814003156 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1274814003157 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 1274814003158 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 1274814003159 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1274814003160 microcin B17 transporter; Reviewed; Region: PRK11098 1274814003161 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 1274814003162 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 1274814003163 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 1274814003164 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 1274814003165 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 1274814003166 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 1274814003167 anti-RssB factor; Provisional; Region: PRK10244 1274814003168 alkaline phosphatase; Provisional; Region: PRK10518 1274814003169 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 1274814003170 dimer interface [polypeptide binding]; other site 1274814003171 active site 1274814003172 hypothetical protein; Provisional; Region: PRK11505 1274814003173 psiF repeat; Region: PsiF_repeat; pfam07769 1274814003174 psiF repeat; Region: PsiF_repeat; pfam07769 1274814003175 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 1274814003176 MASE2 domain; Region: MASE2; pfam05230 1274814003177 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814003178 metal binding site [ion binding]; metal-binding site 1274814003179 active site 1274814003180 I-site; other site 1274814003181 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 1274814003182 pyrroline-5-carboxylate reductase; Region: PLN02688 1274814003183 hypothetical protein; Validated; Region: PRK00124 1274814003184 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 1274814003185 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1274814003186 ADP binding site [chemical binding]; other site 1274814003187 magnesium binding site [ion binding]; other site 1274814003188 putative shikimate binding site; other site 1274814003189 hypothetical protein; Provisional; Region: PRK10380 1274814003190 hypothetical protein; Provisional; Region: PRK10481 1274814003191 hypothetical protein; Provisional; Region: PRK10579 1274814003192 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1274814003193 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 1274814003194 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 1274814003195 fructokinase; Reviewed; Region: PRK09557 1274814003196 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1274814003197 nucleotide binding site [chemical binding]; other site 1274814003198 MFS transport protein AraJ; Provisional; Region: PRK10091 1274814003199 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814003200 putative substrate translocation pore; other site 1274814003201 exonuclease subunit SbcC; Provisional; Region: PRK10246 1274814003202 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814003203 Walker A/P-loop; other site 1274814003204 ATP binding site [chemical binding]; other site 1274814003205 Q-loop/lid; other site 1274814003206 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814003207 ABC transporter signature motif; other site 1274814003208 Walker B; other site 1274814003209 D-loop; other site 1274814003210 H-loop/switch region; other site 1274814003211 exonuclease subunit SbcD; Provisional; Region: PRK10966 1274814003212 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 1274814003213 active site 1274814003214 metal binding site [ion binding]; metal-binding site 1274814003215 DNA binding site [nucleotide binding] 1274814003216 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 1274814003217 transcriptional regulator PhoB; Provisional; Region: PRK10161 1274814003218 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814003219 active site 1274814003220 phosphorylation site [posttranslational modification] 1274814003221 intermolecular recognition site; other site 1274814003222 dimerization interface [polypeptide binding]; other site 1274814003223 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814003224 DNA binding site [nucleotide binding] 1274814003225 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 1274814003226 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 1274814003227 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1274814003228 putative active site [active] 1274814003229 heme pocket [chemical binding]; other site 1274814003230 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814003231 dimer interface [polypeptide binding]; other site 1274814003232 phosphorylation site [posttranslational modification] 1274814003233 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814003234 ATP binding site [chemical binding]; other site 1274814003235 Mg2+ binding site [ion binding]; other site 1274814003236 G-X-G motif; other site 1274814003237 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 1274814003238 putative proline-specific permease; Provisional; Region: proY; PRK10580 1274814003239 Spore germination protein; Region: Spore_permease; cl17796 1274814003240 maltodextrin glucosidase; Provisional; Region: PRK10785 1274814003241 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 1274814003242 homodimer interface [polypeptide binding]; other site 1274814003243 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 1274814003244 active site 1274814003245 homodimer interface [polypeptide binding]; other site 1274814003246 catalytic site [active] 1274814003247 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 1274814003248 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 1274814003249 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 1274814003250 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 1274814003251 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 1274814003252 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 1274814003253 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 1274814003254 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 1274814003255 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1274814003256 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 1274814003257 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 1274814003258 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 1274814003259 Protein export membrane protein; Region: SecD_SecF; pfam02355 1274814003260 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1274814003261 active site 1274814003262 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814003263 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 1274814003264 hypothetical protein; Provisional; Region: PRK11530 1274814003265 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 1274814003266 ATP cone domain; Region: ATP-cone; pfam03477 1274814003267 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 1274814003268 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 1274814003269 catalytic motif [active] 1274814003270 Zn binding site [ion binding]; other site 1274814003271 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 1274814003272 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 1274814003273 homopentamer interface [polypeptide binding]; other site 1274814003274 active site 1274814003275 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 1274814003276 putative RNA binding site [nucleotide binding]; other site 1274814003277 thiamine monophosphate kinase; Provisional; Region: PRK05731 1274814003278 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 1274814003279 ATP binding site [chemical binding]; other site 1274814003280 dimerization interface [polypeptide binding]; other site 1274814003281 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 1274814003282 tetramer interfaces [polypeptide binding]; other site 1274814003283 binuclear metal-binding site [ion binding]; other site 1274814003284 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1274814003285 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1274814003286 active site 1274814003287 catalytic tetrad [active] 1274814003288 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 1274814003289 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 1274814003290 TPP-binding site; other site 1274814003291 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1274814003292 PYR/PP interface [polypeptide binding]; other site 1274814003293 dimer interface [polypeptide binding]; other site 1274814003294 TPP binding site [chemical binding]; other site 1274814003295 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1274814003296 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1274814003297 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1274814003298 substrate binding pocket [chemical binding]; other site 1274814003299 chain length determination region; other site 1274814003300 substrate-Mg2+ binding site; other site 1274814003301 catalytic residues [active] 1274814003302 aspartate-rich region 1; other site 1274814003303 active site lid residues [active] 1274814003304 aspartate-rich region 2; other site 1274814003305 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 1274814003306 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 1274814003307 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 1274814003308 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 1274814003309 Ligand Binding Site [chemical binding]; other site 1274814003310 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1274814003311 active site residue [active] 1274814003312 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 1274814003313 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 1274814003314 conserved cys residue [active] 1274814003315 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 1274814003316 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1274814003317 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 1274814003318 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 1274814003319 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 1274814003320 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814003321 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1274814003322 putative substrate translocation pore; other site 1274814003323 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 1274814003324 UbiA prenyltransferase family; Region: UbiA; pfam01040 1274814003325 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 1274814003326 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 1274814003327 Subunit I/III interface [polypeptide binding]; other site 1274814003328 Subunit III/IV interface [polypeptide binding]; other site 1274814003329 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 1274814003330 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 1274814003331 D-pathway; other site 1274814003332 Putative ubiquinol binding site [chemical binding]; other site 1274814003333 Low-spin heme (heme b) binding site [chemical binding]; other site 1274814003334 Putative water exit pathway; other site 1274814003335 Binuclear center (heme o3/CuB) [ion binding]; other site 1274814003336 K-pathway; other site 1274814003337 Putative proton exit pathway; other site 1274814003338 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 1274814003339 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 1274814003340 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 1274814003341 muropeptide transporter; Reviewed; Region: ampG; PRK11902 1274814003342 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814003343 putative substrate translocation pore; other site 1274814003344 hypothetical protein; Provisional; Region: PRK11627 1274814003345 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 1274814003346 transcriptional regulator BolA; Provisional; Region: PRK11628 1274814003347 trigger factor; Provisional; Region: tig; PRK01490 1274814003348 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1274814003349 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 1274814003350 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 1274814003351 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 1274814003352 oligomer interface [polypeptide binding]; other site 1274814003353 active site residues [active] 1274814003354 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 1274814003355 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 1274814003356 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814003357 Walker A motif; other site 1274814003358 ATP binding site [chemical binding]; other site 1274814003359 Walker B motif; other site 1274814003360 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 1274814003361 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 1274814003362 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1274814003363 Found in ATP-dependent protease La (LON); Region: LON; smart00464 1274814003364 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814003365 Walker A motif; other site 1274814003366 ATP binding site [chemical binding]; other site 1274814003367 Walker B motif; other site 1274814003368 arginine finger; other site 1274814003369 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1274814003370 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1274814003371 IHF dimer interface [polypeptide binding]; other site 1274814003372 IHF - DNA interface [nucleotide binding]; other site 1274814003373 periplasmic folding chaperone; Provisional; Region: PRK10788 1274814003374 SurA N-terminal domain; Region: SurA_N_3; cl07813 1274814003375 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 1274814003376 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 1274814003377 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1274814003378 active site 1274814003379 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 1274814003380 Ligand Binding Site [chemical binding]; other site 1274814003381 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 1274814003382 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 1274814003383 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 1274814003384 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 1274814003385 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814003386 active site 1274814003387 motif I; other site 1274814003388 motif II; other site 1274814003389 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 1274814003390 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1274814003391 putative DNA binding site [nucleotide binding]; other site 1274814003392 putative Zn2+ binding site [ion binding]; other site 1274814003393 AsnC family; Region: AsnC_trans_reg; pfam01037 1274814003394 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1274814003395 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 1274814003396 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814003397 Walker A/P-loop; other site 1274814003398 ATP binding site [chemical binding]; other site 1274814003399 Q-loop/lid; other site 1274814003400 ABC transporter signature motif; other site 1274814003401 Walker B; other site 1274814003402 D-loop; other site 1274814003403 H-loop/switch region; other site 1274814003404 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 1274814003405 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1274814003406 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 1274814003407 Walker A/P-loop; other site 1274814003408 ATP binding site [chemical binding]; other site 1274814003409 Q-loop/lid; other site 1274814003410 ABC transporter signature motif; other site 1274814003411 Walker B; other site 1274814003412 D-loop; other site 1274814003413 H-loop/switch region; other site 1274814003414 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 1274814003415 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1274814003416 ammonium transporter; Provisional; Region: PRK10666 1274814003417 acyl-CoA thioesterase II; Provisional; Region: PRK10526 1274814003418 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 1274814003419 active site 1274814003420 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 1274814003421 catalytic triad [active] 1274814003422 dimer interface [polypeptide binding]; other site 1274814003423 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 1274814003424 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 1274814003425 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1274814003426 DNA binding site [nucleotide binding] 1274814003427 active site 1274814003428 Protein of unknown function (DUF1428); Region: DUF1428; cl02319 1274814003429 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 1274814003430 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1274814003431 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814003432 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 1274814003433 maltose O-acetyltransferase; Provisional; Region: PRK10092 1274814003434 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 1274814003435 active site 1274814003436 substrate binding site [chemical binding]; other site 1274814003437 trimer interface [polypeptide binding]; other site 1274814003438 CoA binding site [chemical binding]; other site 1274814003439 gene expression modulator; Provisional; Region: PRK10945 1274814003440 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 1274814003441 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1274814003442 Protein export membrane protein; Region: SecD_SecF; cl14618 1274814003443 Protein export membrane protein; Region: SecD_SecF; cl14618 1274814003444 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1274814003445 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1274814003446 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814003447 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 1274814003448 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1274814003449 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1274814003450 hypothetical protein; Provisional; Region: PRK11281 1274814003451 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 1274814003452 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 1274814003453 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1274814003454 hypothetical protein; Provisional; Region: PRK11038 1274814003455 primosomal replication protein N''; Provisional; Region: PRK10093 1274814003456 hypothetical protein; Provisional; Region: PRK10527 1274814003457 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1274814003458 active site 1274814003459 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 1274814003460 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814003461 Walker A motif; other site 1274814003462 ATP binding site [chemical binding]; other site 1274814003463 Walker B motif; other site 1274814003464 DNA polymerase III subunit delta'; Validated; Region: PRK08485 1274814003465 arginine finger; other site 1274814003466 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 1274814003467 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 1274814003468 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 1274814003469 hypothetical protein; Validated; Region: PRK00153 1274814003470 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 1274814003471 RecR protein; Region: RecR; pfam02132 1274814003472 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 1274814003473 putative active site [active] 1274814003474 putative metal-binding site [ion binding]; other site 1274814003475 tetramer interface [polypeptide binding]; other site 1274814003476 heat shock protein 90; Provisional; Region: PRK05218 1274814003477 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814003478 ATP binding site [chemical binding]; other site 1274814003479 Mg2+ binding site [ion binding]; other site 1274814003480 G-X-G motif; other site 1274814003481 adenylate kinase; Reviewed; Region: adk; PRK00279 1274814003482 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 1274814003483 AMP-binding site [chemical binding]; other site 1274814003484 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 1274814003485 ferrochelatase; Region: hemH; TIGR00109 1274814003486 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 1274814003487 C-terminal domain interface [polypeptide binding]; other site 1274814003488 active site 1274814003489 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 1274814003490 active site 1274814003491 N-terminal domain interface [polypeptide binding]; other site 1274814003492 acetyl esterase; Provisional; Region: PRK10162 1274814003493 inosine/guanosine kinase; Provisional; Region: PRK15074 1274814003494 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1274814003495 putative cation:proton antiport protein; Provisional; Region: PRK10669 1274814003496 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 1274814003497 TrkA-N domain; Region: TrkA_N; pfam02254 1274814003498 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814003499 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1274814003500 putative substrate translocation pore; other site 1274814003501 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 1274814003502 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 1274814003503 active site 1274814003504 metal binding site [ion binding]; metal-binding site 1274814003505 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 1274814003506 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 1274814003507 putative deacylase active site [active] 1274814003508 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 1274814003509 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1274814003510 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814003511 non-specific DNA binding site [nucleotide binding]; other site 1274814003512 salt bridge; other site 1274814003513 sequence-specific DNA binding site [nucleotide binding]; other site 1274814003514 copper exporting ATPase; Provisional; Region: copA; PRK10671 1274814003515 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1274814003516 metal-binding site [ion binding] 1274814003517 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1274814003518 metal-binding site [ion binding] 1274814003519 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1274814003520 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814003521 motif II; other site 1274814003522 glutaminase; Reviewed; Region: PRK12356 1274814003523 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1274814003524 amino acid transporter; Region: 2A0306; TIGR00909 1274814003525 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 1274814003526 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 1274814003527 DNA binding residues [nucleotide binding] 1274814003528 dimer interface [polypeptide binding]; other site 1274814003529 copper binding site [ion binding]; other site 1274814003530 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 1274814003531 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 1274814003532 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 1274814003533 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 1274814003534 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814003535 Walker A/P-loop; other site 1274814003536 ATP binding site [chemical binding]; other site 1274814003537 Q-loop/lid; other site 1274814003538 ABC transporter signature motif; other site 1274814003539 Walker B; other site 1274814003540 D-loop; other site 1274814003541 H-loop/switch region; other site 1274814003542 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 1274814003543 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 1274814003544 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 1274814003545 oxidoreductase; Provisional; Region: PRK08017 1274814003546 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 1274814003547 NADP binding site [chemical binding]; other site 1274814003548 active site 1274814003549 steroid binding site; other site 1274814003550 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 1274814003551 active site 1274814003552 catalytic triad [active] 1274814003553 oxyanion hole [active] 1274814003554 switch loop; other site 1274814003555 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 1274814003556 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1274814003557 Walker A/P-loop; other site 1274814003558 ATP binding site [chemical binding]; other site 1274814003559 Q-loop/lid; other site 1274814003560 ABC transporter signature motif; other site 1274814003561 Walker B; other site 1274814003562 D-loop; other site 1274814003563 H-loop/switch region; other site 1274814003564 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 1274814003565 FtsX-like permease family; Region: FtsX; pfam02687 1274814003566 FtsX-like permease family; Region: FtsX; pfam02687 1274814003567 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814003568 Predicted ATPase [General function prediction only]; Region: COG2603 1274814003569 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 1274814003570 active site residue [active] 1274814003571 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 1274814003572 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814003573 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1274814003574 dimerization interface [polypeptide binding]; other site 1274814003575 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 1274814003576 ureidoglycolate hydrolase; Provisional; Region: PRK03606 1274814003577 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 1274814003578 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1274814003579 Bacterial transcriptional regulator; Region: IclR; pfam01614 1274814003580 glyoxylate carboligase; Provisional; Region: PRK11269 1274814003581 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1274814003582 PYR/PP interface [polypeptide binding]; other site 1274814003583 dimer interface [polypeptide binding]; other site 1274814003584 TPP binding site [chemical binding]; other site 1274814003585 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1274814003586 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 1274814003587 TPP-binding site [chemical binding]; other site 1274814003588 hydroxypyruvate isomerase; Provisional; Region: PRK09997 1274814003589 tartronate semialdehyde reductase; Provisional; Region: PRK15059 1274814003590 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1274814003591 potential frameshift: common BLAST hit: gi|386708311|ref|YP_006172032.1| allantoin permease 1274814003592 allantoinase; Provisional; Region: PRK08044 1274814003593 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 1274814003594 active site 1274814003595 putative uracil/xanthine transporter; Provisional; Region: PRK11412 1274814003596 glycerate kinase II; Provisional; Region: PRK09932 1274814003597 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 1274814003598 Protein of unknown function (DUF861); Region: Cupin_3; pfam05899 1274814003599 Cupin domain; Region: Cupin_2; cl17218 1274814003600 allantoate amidohydrolase; Region: AllC; TIGR03176 1274814003601 M20 Peptidase beta-alanine synthase, an amidohydrolase; Region: M20_bAS; cd03884 1274814003602 active site 1274814003603 metal binding site [ion binding]; metal-binding site 1274814003604 dimer interface [polypeptide binding]; other site 1274814003605 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 1274814003606 membrane protein FdrA; Validated; Region: PRK06091 1274814003607 CoA binding domain; Region: CoA_binding; pfam02629 1274814003608 CoA-ligase; Region: Ligase_CoA; pfam00549 1274814003609 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 1274814003610 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 1274814003611 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 1274814003612 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1274814003613 putative substrate binding site [chemical binding]; other site 1274814003614 nucleotide binding site [chemical binding]; other site 1274814003615 nucleotide binding site [chemical binding]; other site 1274814003616 homodimer interface [polypeptide binding]; other site 1274814003617 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814003618 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 1274814003619 ATP-grasp domain; Region: ATP-grasp; pfam02222 1274814003620 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 1274814003621 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 1274814003622 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1274814003623 putative active site [active] 1274814003624 putative metal binding site [ion binding]; other site 1274814003625 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1274814003626 substrate binding site [chemical binding]; other site 1274814003627 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 1274814003628 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1274814003629 active site 1274814003630 HIGH motif; other site 1274814003631 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 1274814003632 KMSKS motif; other site 1274814003633 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 1274814003634 tRNA binding surface [nucleotide binding]; other site 1274814003635 anticodon binding site; other site 1274814003636 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 1274814003637 ribosome-associated protein; Provisional; Region: PRK11507 1274814003638 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 1274814003639 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 1274814003640 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 1274814003641 homodimer interface [polypeptide binding]; other site 1274814003642 NADP binding site [chemical binding]; other site 1274814003643 substrate binding site [chemical binding]; other site 1274814003644 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 1274814003645 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1274814003646 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1274814003647 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1274814003648 PapC N-terminal domain; Region: PapC_N; pfam13954 1274814003649 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1274814003650 PapC C-terminal domain; Region: PapC_C; pfam13953 1274814003651 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 1274814003652 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 1274814003653 transcriptional regulator FimZ; Provisional; Region: PRK09935 1274814003654 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814003655 active site 1274814003656 phosphorylation site [posttranslational modification] 1274814003657 intermolecular recognition site; other site 1274814003658 dimerization interface [polypeptide binding]; other site 1274814003659 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814003660 DNA binding residues [nucleotide binding] 1274814003661 dimerization interface [polypeptide binding]; other site 1274814003662 P22-like integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various bacterial and phage integrases, including those similar to phage P22-like integrases, DLP12 and APSE-1; Region: INT_P22_C; cd01192 1274814003663 Int/Topo IB signature motif; other site 1274814003664 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 1274814003665 Uncharacterized conserved protein [Function unknown]; Region: COG5532 1274814003666 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 1274814003667 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1274814003668 Bor protein; Region: Lambda_Bor; pfam06291 1274814003669 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1274814003670 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1274814003671 catalytic residues [active] 1274814003672 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 1274814003673 Lysis protein S; Region: Lysis_S; pfam04971 1274814003674 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1274814003675 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814003676 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1274814003677 DNA methylase; Region: N6_N4_Mtase; pfam01555 1274814003678 EAP30/Vps36 family; Region: EAP30; pfam04157 1274814003679 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1274814003680 Protein of unknown function (DUF968); Region: DUF968; pfam06147 1274814003681 KilA-N domain; Region: KilA-N; pfam04383 1274814003682 Endodeoxyribonuclease RusA; Region: RusA; pfam05866 1274814003683 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 1274814003684 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; pfam05869 1274814003685 PerC transcriptional activator; Region: PerC; pfam06069 1274814003686 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 1274814003687 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1274814003688 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1274814003689 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1274814003690 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1274814003691 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1274814003692 catalytic residues [active] 1274814003693 catalytic nucleophile [active] 1274814003694 Presynaptic Site I dimer interface [polypeptide binding]; other site 1274814003695 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1274814003696 Synaptic Flat tetramer interface [polypeptide binding]; other site 1274814003697 Synaptic Site I dimer interface [polypeptide binding]; other site 1274814003698 DNA binding site [nucleotide binding] 1274814003699 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1274814003700 DNA-binding interface [nucleotide binding]; DNA binding site 1274814003701 Methyltransferase domain; Region: Methyltransf_12; pfam08242 1274814003702 S-adenosylmethionine binding site [chemical binding]; other site 1274814003703 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1274814003704 alpha/beta hydrolase fold; Region: Abhydrolase_1; pfam00561 1274814003705 TAP-like protein; Region: Abhydrolase_4; pfam08386 1274814003706 outer membrane protease; Reviewed; Region: PRK10993 1274814003707 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1274814003708 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814003709 hypothetical protein; Provisional; Region: PRK09936 1274814003710 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1274814003711 binding surface 1274814003712 TPR motif; other site 1274814003713 TPR repeat; Region: TPR_11; pfam13414 1274814003714 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1274814003715 binding surface 1274814003716 TPR motif; other site 1274814003717 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 1274814003718 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 1274814003719 active site 1274814003720 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1274814003721 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 1274814003722 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1274814003723 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1274814003724 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1274814003725 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1274814003726 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1274814003727 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1274814003728 PAAR motif; Region: PAAR_motif; pfam05488 1274814003729 RHS Repeat; Region: RHS_repeat; cl11982 1274814003730 RHS Repeat; Region: RHS_repeat; pfam05593 1274814003731 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1274814003732 Uncharacterized conserved protein [Function unknown]; Region: COG5435 1274814003733 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1274814003734 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1274814003735 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1274814003736 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1274814003737 sensor kinase CusS; Provisional; Region: PRK09835 1274814003738 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1274814003739 dimerization interface [polypeptide binding]; other site 1274814003740 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814003741 dimer interface [polypeptide binding]; other site 1274814003742 phosphorylation site [posttranslational modification] 1274814003743 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814003744 ATP binding site [chemical binding]; other site 1274814003745 Mg2+ binding site [ion binding]; other site 1274814003746 G-X-G motif; other site 1274814003747 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 1274814003748 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814003749 active site 1274814003750 phosphorylation site [posttranslational modification] 1274814003751 intermolecular recognition site; other site 1274814003752 dimerization interface [polypeptide binding]; other site 1274814003753 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814003754 DNA binding site [nucleotide binding] 1274814003755 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 1274814003756 periplasmic copper-binding protein; Provisional; Region: PRK09838 1274814003757 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 1274814003758 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814003759 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 1274814003760 phenylalanine transporter; Provisional; Region: PRK10249 1274814003761 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1274814003762 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1274814003763 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 1274814003764 dimer interface [polypeptide binding]; other site 1274814003765 FMN binding site [chemical binding]; other site 1274814003766 hypothetical protein; Provisional; Region: PRK10250 1274814003767 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 1274814003768 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 1274814003769 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 1274814003770 Hok/gef family; Region: HOK_GEF; pfam01848 1274814003771 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 1274814003772 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1274814003773 outer membrane receptor FepA; Provisional; Region: PRK13524 1274814003774 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1274814003775 N-terminal plug; other site 1274814003776 ligand-binding site [chemical binding]; other site 1274814003777 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 1274814003778 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 1274814003779 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1274814003780 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 1274814003781 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 1274814003782 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 1274814003783 acyl-activating enzyme (AAE) consensus motif; other site 1274814003784 AMP binding site [chemical binding]; other site 1274814003785 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1274814003786 LPS O-antigen length regulator; Provisional; Region: PRK10381 1274814003787 Chain length determinant protein; Region: Wzz; pfam02706 1274814003788 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1274814003789 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 1274814003790 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1274814003791 Walker A/P-loop; other site 1274814003792 ATP binding site [chemical binding]; other site 1274814003793 Q-loop/lid; other site 1274814003794 ABC transporter signature motif; other site 1274814003795 Walker B; other site 1274814003796 D-loop; other site 1274814003797 H-loop/switch region; other site 1274814003798 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 1274814003799 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1274814003800 ABC-ATPase subunit interface; other site 1274814003801 dimer interface [polypeptide binding]; other site 1274814003802 putative PBP binding regions; other site 1274814003803 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1274814003804 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1274814003805 ABC-ATPase subunit interface; other site 1274814003806 dimer interface [polypeptide binding]; other site 1274814003807 putative PBP binding regions; other site 1274814003808 enterobactin exporter EntS; Provisional; Region: PRK10489 1274814003809 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814003810 putative substrate translocation pore; other site 1274814003811 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 1274814003812 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 1274814003813 siderophore binding site; other site 1274814003814 isochorismate synthase EntC; Provisional; Region: PRK15016 1274814003815 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1274814003816 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 1274814003817 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 1274814003818 acyl-activating enzyme (AAE) consensus motif; other site 1274814003819 active site 1274814003820 AMP binding site [chemical binding]; other site 1274814003821 substrate binding site [chemical binding]; other site 1274814003822 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 1274814003823 hydrophobic substrate binding pocket; other site 1274814003824 Isochorismatase family; Region: Isochorismatase; pfam00857 1274814003825 active site 1274814003826 conserved cis-peptide bond; other site 1274814003827 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 1274814003828 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 1274814003829 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 1274814003830 putative NAD(P) binding site [chemical binding]; other site 1274814003831 active site 1274814003832 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1274814003833 CoenzymeA binding site [chemical binding]; other site 1274814003834 subunit interaction site [polypeptide binding]; other site 1274814003835 PHB binding site; other site 1274814003836 carbon starvation protein A; Provisional; Region: PRK15015 1274814003837 Carbon starvation protein CstA; Region: CstA; pfam02554 1274814003838 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 1274814003839 Uncharacterized small protein [Function unknown]; Region: COG2879 1274814003840 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 1274814003841 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 1274814003842 putative active site [active] 1274814003843 metal binding site [ion binding]; metal-binding site 1274814003844 methionine aminotransferase; Validated; Region: PRK09082 1274814003845 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1274814003846 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814003847 homodimer interface [polypeptide binding]; other site 1274814003848 catalytic residue [active] 1274814003849 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1274814003850 ParB-like nuclease domain; Region: ParBc; pfam02195 1274814003851 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 1274814003852 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1274814003853 Active Sites [active] 1274814003854 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 1274814003855 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1274814003856 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814003857 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1274814003858 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 1274814003859 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1274814003860 dimerization domain [polypeptide binding]; other site 1274814003861 dimer interface [polypeptide binding]; other site 1274814003862 catalytic residues [active] 1274814003863 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 1274814003864 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 1274814003865 dimer interface [polypeptide binding]; other site 1274814003866 decamer (pentamer of dimers) interface [polypeptide binding]; other site 1274814003867 catalytic triad [active] 1274814003868 peroxidatic and resolving cysteines [active] 1274814003869 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 1274814003870 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 1274814003871 catalytic residue [active] 1274814003872 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 1274814003873 catalytic residues [active] 1274814003874 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1274814003875 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1274814003876 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1274814003877 Ligand Binding Site [chemical binding]; other site 1274814003878 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 1274814003879 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1274814003880 NAD binding site [chemical binding]; other site 1274814003881 catalytic Zn binding site [ion binding]; other site 1274814003882 structural Zn binding site [ion binding]; other site 1274814003883 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 1274814003884 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1274814003885 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 1274814003886 B1 nucleotide binding pocket [chemical binding]; other site 1274814003887 B2 nucleotide binding pocket [chemical binding]; other site 1274814003888 CAS motifs; other site 1274814003889 active site 1274814003890 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1274814003891 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1274814003892 transmembrane helices; other site 1274814003893 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 1274814003894 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 1274814003895 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 1274814003896 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1274814003897 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 1274814003898 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 1274814003899 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 1274814003900 putative active site [active] 1274814003901 (T/H)XGH motif; other site 1274814003902 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 1274814003903 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1274814003904 putative active site [active] 1274814003905 heme pocket [chemical binding]; other site 1274814003906 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814003907 ATP binding site [chemical binding]; other site 1274814003908 Mg2+ binding site [ion binding]; other site 1274814003909 G-X-G motif; other site 1274814003910 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 1274814003911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814003912 active site 1274814003913 phosphorylation site [posttranslational modification] 1274814003914 intermolecular recognition site; other site 1274814003915 dimerization interface [polypeptide binding]; other site 1274814003916 Transcriptional regulator; Region: CitT; pfam12431 1274814003917 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 1274814003918 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1274814003919 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 1274814003920 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1274814003921 DNA-binding site [nucleotide binding]; DNA binding site 1274814003922 RNA-binding motif; other site 1274814003923 chromosome condensation membrane protein; Provisional; Region: PRK14196 1274814003924 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1274814003925 Uncharacterized subgroup of the nitrilase superfamily (putative class 13 nitrilases); Region: nitrilase_3; cd07581 1274814003926 putative active site [active] 1274814003927 catalytic triad [active] 1274814003928 putative dimer interface [polypeptide binding]; other site 1274814003929 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 1274814003930 lipoyl synthase; Provisional; Region: PRK05481 1274814003931 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814003932 FeS/SAM binding site; other site 1274814003933 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 1274814003934 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814003935 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1274814003936 substrate binding pocket [chemical binding]; other site 1274814003937 dimerization interface [polypeptide binding]; other site 1274814003938 lipoate-protein ligase B; Provisional; Region: PRK14342 1274814003939 hypothetical protein; Provisional; Region: PRK04998 1274814003940 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 1274814003941 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1274814003942 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1274814003943 rare lipoprotein A; Provisional; Region: PRK10672 1274814003944 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 1274814003945 Sporulation related domain; Region: SPOR; pfam05036 1274814003946 cell wall shape-determining protein; Provisional; Region: PRK10794 1274814003947 penicillin-binding protein 2; Provisional; Region: PRK10795 1274814003948 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 1274814003949 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 1274814003950 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 1274814003951 ribosome-associated protein; Provisional; Region: PRK11538 1274814003952 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1274814003953 catalytic core [active] 1274814003954 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 1274814003955 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 1274814003956 active site 1274814003957 (T/H)XGH motif; other site 1274814003958 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 1274814003959 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 1274814003960 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 1274814003961 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 1274814003962 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 1274814003963 HIGH motif; other site 1274814003964 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 1274814003965 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1274814003966 active site 1274814003967 KMSKS motif; other site 1274814003968 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 1274814003969 tRNA binding surface [nucleotide binding]; other site 1274814003970 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 1274814003971 hypothetical protein; Provisional; Region: PRK11032 1274814003972 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 1274814003973 Sel1-like repeats; Region: SEL1; smart00671 1274814003974 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1274814003975 Sel1-like repeats; Region: SEL1; smart00671 1274814003976 Sel1-like repeats; Region: SEL1; smart00671 1274814003977 Sel1-like repeats; Region: SEL1; smart00671 1274814003978 Sel1-like repeats; Region: SEL1; smart00671 1274814003979 Sel1-like repeats; Region: SEL1; smart00671 1274814003980 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1274814003981 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 1274814003982 HSP70 interaction site [polypeptide binding]; other site 1274814003983 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1274814003984 Sel1-like repeats; Region: SEL1; smart00671 1274814003985 Sel1-like repeats; Region: SEL1; smart00671 1274814003986 Sel1-like repeats; Region: SEL1; smart00671 1274814003987 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 1274814003988 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 1274814003989 potential frameshift: common BLAST hit: gi|386708433|ref|YP_006172154.1| HSP70 family chaperone Hsc62, binds to RpoD and inhibits 1274814003990 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1274814003991 active site 1274814003992 tetramer interface [polypeptide binding]; other site 1274814003993 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1274814003994 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1274814003995 Walker A/P-loop; other site 1274814003996 ATP binding site [chemical binding]; other site 1274814003997 Q-loop/lid; other site 1274814003998 ABC transporter signature motif; other site 1274814003999 Walker B; other site 1274814004000 D-loop; other site 1274814004001 H-loop/switch region; other site 1274814004002 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1274814004003 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814004004 dimer interface [polypeptide binding]; other site 1274814004005 conserved gate region; other site 1274814004006 putative PBP binding loops; other site 1274814004007 ABC-ATPase subunit interface; other site 1274814004008 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1274814004009 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814004010 dimer interface [polypeptide binding]; other site 1274814004011 conserved gate region; other site 1274814004012 putative PBP binding loops; other site 1274814004013 ABC-ATPase subunit interface; other site 1274814004014 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1274814004015 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814004016 substrate binding pocket [chemical binding]; other site 1274814004017 membrane-bound complex binding site; other site 1274814004018 hinge residues; other site 1274814004019 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1274814004020 Uncharacterized conserved protein [Function unknown]; Region: COG3391 1274814004021 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1274814004022 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 1274814004023 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 1274814004024 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 1274814004025 putative active site [active] 1274814004026 catalytic triad [active] 1274814004027 putative dimer interface [polypeptide binding]; other site 1274814004028 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 1274814004029 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1274814004030 Transporter associated domain; Region: CorC_HlyC; smart01091 1274814004031 metal-binding heat shock protein; Provisional; Region: PRK00016 1274814004032 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1274814004033 PhoH-like protein; Region: PhoH; pfam02562 1274814004034 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 1274814004035 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1274814004036 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814004037 FeS/SAM binding site; other site 1274814004038 TRAM domain; Region: TRAM; pfam01938 1274814004039 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 1274814004040 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 1274814004041 asparagine synthetase B; Provisional; Region: asnB; PRK09431 1274814004042 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 1274814004043 active site 1274814004044 dimer interface [polypeptide binding]; other site 1274814004045 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 1274814004046 Ligand Binding Site [chemical binding]; other site 1274814004047 Molecular Tunnel; other site 1274814004048 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814004049 UMP phosphatase; Provisional; Region: PRK10444 1274814004050 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814004051 active site 1274814004052 motif I; other site 1274814004053 motif II; other site 1274814004054 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814004055 MarR family; Region: MarR; pfam01047 1274814004056 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1274814004057 ROK family; Region: ROK; pfam00480 1274814004058 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 1274814004059 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1274814004060 active site 1274814004061 dimer interface [polypeptide binding]; other site 1274814004062 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1274814004063 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1274814004064 active site 1274814004065 trimer interface [polypeptide binding]; other site 1274814004066 allosteric site; other site 1274814004067 active site lid [active] 1274814004068 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1274814004069 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 1274814004070 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1274814004071 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1274814004072 active site turn [active] 1274814004073 phosphorylation site [posttranslational modification] 1274814004074 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1274814004075 HPr interaction site; other site 1274814004076 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1274814004077 active site 1274814004078 phosphorylation site [posttranslational modification] 1274814004079 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 1274814004080 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 1274814004081 active site 1274814004082 HIGH motif; other site 1274814004083 nucleotide binding site [chemical binding]; other site 1274814004084 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 1274814004085 KMSKS motif; other site 1274814004086 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 1274814004087 outer membrane porin, OprD family; Region: OprD; pfam03573 1274814004088 YbfN-like lipoprotein; Region: YbfN; pfam13982 1274814004089 ferric uptake regulator; Provisional; Region: fur; PRK09462 1274814004090 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 1274814004091 metal binding site 2 [ion binding]; metal-binding site 1274814004092 putative DNA binding helix; other site 1274814004093 metal binding site 1 [ion binding]; metal-binding site 1274814004094 dimer interface [polypeptide binding]; other site 1274814004095 structural Zn2+ binding site [ion binding]; other site 1274814004096 ryhB-regulated fur leader peptide; Provisional; Region: PRK14761 1274814004097 flavodoxin FldA; Validated; Region: PRK09267 1274814004098 LexA regulated protein; Provisional; Region: PRK11675 1274814004099 acyl-CoA esterase; Provisional; Region: PRK10673 1274814004100 PGAP1-like protein; Region: PGAP1; pfam07819 1274814004101 replication initiation regulator SeqA; Provisional; Region: PRK11187 1274814004102 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 1274814004103 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 1274814004104 active site 1274814004105 substrate binding site [chemical binding]; other site 1274814004106 metal binding site [ion binding]; metal-binding site 1274814004107 putrescine transporter; Provisional; Region: potE; PRK10655 1274814004108 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 1274814004109 ornithine decarboxylase; Provisional; Region: PRK13578 1274814004110 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1274814004111 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1274814004112 homodimer interface [polypeptide binding]; other site 1274814004113 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814004114 catalytic residue [active] 1274814004115 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1274814004116 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 1274814004117 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814004118 active site 1274814004119 phosphorylation site [posttranslational modification] 1274814004120 intermolecular recognition site; other site 1274814004121 dimerization interface [polypeptide binding]; other site 1274814004122 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814004123 DNA binding site [nucleotide binding] 1274814004124 sensor protein KdpD; Provisional; Region: PRK10490 1274814004125 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 1274814004126 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 1274814004127 Ligand Binding Site [chemical binding]; other site 1274814004128 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 1274814004129 GAF domain; Region: GAF_3; pfam13492 1274814004130 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814004131 dimer interface [polypeptide binding]; other site 1274814004132 phosphorylation site [posttranslational modification] 1274814004133 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814004134 ATP binding site [chemical binding]; other site 1274814004135 Mg2+ binding site [ion binding]; other site 1274814004136 G-X-G motif; other site 1274814004137 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 1274814004138 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 1274814004139 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1274814004140 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 1274814004141 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 1274814004142 PAAR motif; Region: PAAR_motif; cl15808 1274814004143 RHS Repeat; Region: RHS_repeat; pfam05593 1274814004144 RHS Repeat; Region: RHS_repeat; cl11982 1274814004145 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1274814004146 RHS Repeat; Region: RHS_repeat; pfam05593 1274814004147 RHS Repeat; Region: RHS_repeat; pfam05593 1274814004148 RHS protein; Region: RHS; pfam03527 1274814004149 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1274814004150 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1274814004151 RHS protein; Region: RHS; pfam03527 1274814004152 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1274814004153 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1274814004154 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1274814004155 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1274814004156 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1274814004157 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1274814004158 hypothetical protein; Provisional; Region: PRK10167 1274814004159 Uncharacterized conserved protein [Function unknown]; Region: COG3272 1274814004160 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 1274814004161 DNA photolyase; Region: DNA_photolyase; pfam00875 1274814004162 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1274814004163 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814004164 putative substrate translocation pore; other site 1274814004165 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814004166 Uncharacterized conserved protein [Function unknown]; Region: COG0327 1274814004167 metal-binding protein; Provisional; Region: PRK10799 1274814004168 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 1274814004169 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 1274814004170 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 1274814004171 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 1274814004172 putative active site [active] 1274814004173 endonuclease VIII; Provisional; Region: PRK10445 1274814004174 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 1274814004175 DNA binding site [nucleotide binding] 1274814004176 catalytic residue [active] 1274814004177 putative catalytic residues [active] 1274814004178 H2TH interface [polypeptide binding]; other site 1274814004179 intercalation triad [nucleotide binding]; other site 1274814004180 substrate specificity determining residue; other site 1274814004181 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1274814004182 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1274814004183 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 1274814004184 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1274814004185 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 1274814004186 Fimbrial protein; Region: Fimbrial; pfam00419 1274814004187 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1274814004188 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1274814004189 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1274814004190 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1274814004191 PapC N-terminal domain; Region: PapC_N; pfam13954 1274814004192 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1274814004193 PapC C-terminal domain; Region: PapC_C; pfam13953 1274814004194 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1274814004195 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 1274814004196 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 1274814004197 dimer interface [polypeptide binding]; other site 1274814004198 active site 1274814004199 citrylCoA binding site [chemical binding]; other site 1274814004200 NADH binding [chemical binding]; other site 1274814004201 cationic pore residues; other site 1274814004202 oxalacetate/citrate binding site [chemical binding]; other site 1274814004203 coenzyme A binding site [chemical binding]; other site 1274814004204 catalytic triad [active] 1274814004205 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 1274814004206 Iron-sulfur protein interface; other site 1274814004207 proximal quinone binding site [chemical binding]; other site 1274814004208 SdhD (CybS) interface [polypeptide binding]; other site 1274814004209 proximal heme binding site [chemical binding]; other site 1274814004210 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 1274814004211 SdhC subunit interface [polypeptide binding]; other site 1274814004212 proximal heme binding site [chemical binding]; other site 1274814004213 cardiolipin binding site; other site 1274814004214 Iron-sulfur protein interface; other site 1274814004215 proximal quinone binding site [chemical binding]; other site 1274814004216 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 1274814004217 L-aspartate oxidase; Provisional; Region: PRK06175 1274814004218 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1274814004219 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 1274814004220 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 1274814004221 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814004222 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 1274814004223 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 1274814004224 TPP-binding site [chemical binding]; other site 1274814004225 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 1274814004226 dimer interface [polypeptide binding]; other site 1274814004227 PYR/PP interface [polypeptide binding]; other site 1274814004228 TPP binding site [chemical binding]; other site 1274814004229 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 1274814004230 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 1274814004231 E3 interaction surface; other site 1274814004232 lipoyl attachment site [posttranslational modification]; other site 1274814004233 e3 binding domain; Region: E3_binding; pfam02817 1274814004234 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 1274814004235 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 1274814004236 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 1274814004237 CoA-ligase; Region: Ligase_CoA; pfam00549 1274814004238 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 1274814004239 CoA binding domain; Region: CoA_binding; smart00881 1274814004240 CoA-ligase; Region: Ligase_CoA; pfam00549 1274814004241 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 1274814004242 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814004243 DNA-binding site [nucleotide binding]; DNA binding site 1274814004244 UTRA domain; Region: UTRA; pfam07702 1274814004245 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 1274814004246 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1274814004247 active site 1274814004248 phosphorylation site [posttranslational modification] 1274814004249 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1274814004250 active site 1274814004251 P-loop; other site 1274814004252 phosphorylation site [posttranslational modification] 1274814004253 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1274814004254 alpha-mannosidase; Provisional; Region: PRK09819 1274814004255 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 1274814004256 active site 1274814004257 metal binding site [ion binding]; metal-binding site 1274814004258 catalytic site [active] 1274814004259 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 1274814004260 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1274814004261 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 1274814004262 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 1274814004263 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 1274814004264 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1274814004265 hypothetical protein; Provisional; Region: PRK10588 1274814004266 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 1274814004267 active site 1274814004268 colicin uptake protein TolQ; Provisional; Region: PRK10801 1274814004269 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1274814004270 colicin uptake protein TolR; Provisional; Region: PRK11024 1274814004271 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1274814004272 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 1274814004273 TolA C-terminal; Region: TolA; pfam06519 1274814004274 translocation protein TolB; Provisional; Region: tolB; PRK03629 1274814004275 TolB amino-terminal domain; Region: TolB_N; pfam04052 1274814004276 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1274814004277 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1274814004278 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 1274814004279 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 1274814004280 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1274814004281 ligand binding site [chemical binding]; other site 1274814004282 tol-pal system protein YbgF; Provisional; Region: PRK10803 1274814004283 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1274814004284 Tetratricopeptide repeat; Region: TPR_6; pfam13174 1274814004285 quinolinate synthetase; Provisional; Region: PRK09375 1274814004286 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 1274814004287 zinc transporter ZitB; Provisional; Region: PRK03557 1274814004288 YbgS-like protein; Region: YbgS; pfam13985 1274814004289 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 1274814004290 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1274814004291 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1274814004292 catalytic core [active] 1274814004293 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1274814004294 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 1274814004295 active site 1274814004296 catalytic residues [active] 1274814004297 galactokinase; Provisional; Region: PRK05101 1274814004298 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 1274814004299 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1274814004300 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 1274814004301 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 1274814004302 dimer interface [polypeptide binding]; other site 1274814004303 active site 1274814004304 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 1274814004305 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 1274814004306 NAD binding site [chemical binding]; other site 1274814004307 homodimer interface [polypeptide binding]; other site 1274814004308 active site 1274814004309 substrate binding site [chemical binding]; other site 1274814004310 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 1274814004311 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 1274814004312 Walker A/P-loop; other site 1274814004313 ATP binding site [chemical binding]; other site 1274814004314 Q-loop/lid; other site 1274814004315 ABC transporter signature motif; other site 1274814004316 Walker B; other site 1274814004317 D-loop; other site 1274814004318 H-loop/switch region; other site 1274814004319 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814004320 Walker A/P-loop; other site 1274814004321 ATP binding site [chemical binding]; other site 1274814004322 Q-loop/lid; other site 1274814004323 ABC transporter signature motif; other site 1274814004324 Walker B; other site 1274814004325 D-loop; other site 1274814004326 H-loop/switch region; other site 1274814004327 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 1274814004328 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 1274814004329 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1274814004330 TOBE domain; Region: TOBE; pfam03459 1274814004331 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 1274814004332 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 1274814004333 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814004334 substrate binding pocket [chemical binding]; other site 1274814004335 membrane-bound complex binding site; other site 1274814004336 hinge residues; other site 1274814004337 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1274814004338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814004339 putative PBP binding loops; other site 1274814004340 ABC-ATPase subunit interface; other site 1274814004341 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 1274814004342 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814004343 Walker A/P-loop; other site 1274814004344 ATP binding site [chemical binding]; other site 1274814004345 Q-loop/lid; other site 1274814004346 ABC transporter signature motif; other site 1274814004347 Walker B; other site 1274814004348 D-loop; other site 1274814004349 H-loop/switch region; other site 1274814004350 molybdenum-pterin binding domain; Region: Mop; TIGR00638 1274814004351 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 1274814004352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814004353 motif II; other site 1274814004354 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814004355 6-phosphogluconolactonase; Provisional; Region: PRK11028 1274814004356 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1274814004357 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814004358 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1274814004359 putative dimerization interface [polypeptide binding]; other site 1274814004360 PrpF protein; Region: PrpF; pfam04303 1274814004361 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1274814004362 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1274814004363 transmembrane helices; other site 1274814004364 putative hydratase; Provisional; Region: PRK11413 1274814004365 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 1274814004366 substrate binding site [chemical binding]; other site 1274814004367 ligand binding site [chemical binding]; other site 1274814004368 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 1274814004369 substrate binding site [chemical binding]; other site 1274814004370 acyl-CoA thioesterase; Provisional; Region: PRK10531 1274814004371 putative pectinesterase; Region: PLN02432; cl01911 1274814004372 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1274814004373 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 1274814004374 tyrosine recombinase XerC; Region: recomb_XerC; TIGR02224 1274814004375 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 1274814004376 dimer interface [polypeptide binding]; other site 1274814004377 active site 1274814004378 Int/Topo IB signature motif; other site 1274814004379 Excisionase-like protein; Region: Exc; pfam07825 1274814004380 IS2 repressor TnpA; Reviewed; Region: PRK09413 1274814004381 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814004382 IS2 transposase TnpB; Reviewed; Region: PRK09409 1274814004383 HTH-like domain; Region: HTH_21; pfam13276 1274814004384 Integrase core domain; Region: rve; pfam00665 1274814004385 Integrase core domain; Region: rve_3; pfam13683 1274814004386 Protein of unknown function (DUF550); Region: DUF550; pfam04447 1274814004387 Protein of unknown function (DUF551); Region: DUF551; pfam04448 1274814004388 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 1274814004389 DksA-like zinc finger domain containing protein; Region: PHA00080 1274814004390 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 1274814004391 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 1274814004392 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 1274814004393 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 1274814004394 Protein of unknown function (DUF2528); Region: DUF2528; pfam10800 1274814004395 Antirestriction protein Ral; Region: Ral; pfam11058 1274814004396 Phage antitermination protein Q; Region: Phage_antitermQ; pfam06530 1274814004397 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1274814004398 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1274814004399 trimer interface [polypeptide binding]; other site 1274814004400 eyelet of channel; other site 1274814004401 Lysis protein S; Region: Lysis_S; pfam04971 1274814004402 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1274814004403 catalytic residues [active] 1274814004404 Bacteriophage lysis protein; Region: Phage_lysis; pfam03245 1274814004405 Bor protein; Region: Lambda_Bor; pfam06291 1274814004406 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 1274814004407 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 1274814004408 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1274814004409 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 1274814004410 Fibronectin type III protein; Region: DUF3672; pfam12421 1274814004411 Enterobacterial Ail/Lom protein; Region: Ail_Lom; pfam06316 1274814004412 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 1274814004413 Chaperone of endosialidase; Region: Peptidase_S74; pfam13884 1274814004414 transcriptional regulator YdeO; Provisional; Region: PRK09940 1274814004415 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814004416 Integrase core domain; Region: rve; pfam00665 1274814004417 Integrase core domain; Region: rve_3; pfam13683 1274814004418 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814004419 Transposase; Region: HTH_Tnp_1; pfam01527 1274814004420 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1274814004421 substrate binding site [chemical binding]; other site 1274814004422 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 1274814004423 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1274814004424 inhibitor-cofactor binding pocket; inhibition site 1274814004425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814004426 catalytic residue [active] 1274814004427 biotin synthase; Provisional; Region: PRK15108 1274814004428 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814004429 FeS/SAM binding site; other site 1274814004430 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 1274814004431 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1274814004432 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1274814004433 substrate-cofactor binding pocket; other site 1274814004434 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814004435 catalytic residue [active] 1274814004436 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 1274814004437 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814004438 S-adenosylmethionine binding site [chemical binding]; other site 1274814004439 AAA domain; Region: AAA_26; pfam13500 1274814004440 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1274814004441 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 1274814004442 ADP binding site [chemical binding]; other site 1274814004443 excinuclease ABC subunit B; Provisional; Region: PRK05298 1274814004444 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1274814004445 ATP binding site [chemical binding]; other site 1274814004446 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1274814004447 nucleotide binding region [chemical binding]; other site 1274814004448 ATP-binding site [chemical binding]; other site 1274814004449 Ultra-violet resistance protein B; Region: UvrB; pfam12344 1274814004450 UvrB/uvrC motif; Region: UVR; pfam02151 1274814004451 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 1274814004452 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 1274814004453 putative substrate binding pocket [chemical binding]; other site 1274814004454 dimer interface [polypeptide binding]; other site 1274814004455 phosphate binding site [ion binding]; other site 1274814004456 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 1274814004457 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814004458 FeS/SAM binding site; other site 1274814004459 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 1274814004460 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 1274814004461 MPT binding site; other site 1274814004462 trimer interface [polypeptide binding]; other site 1274814004463 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 1274814004464 trimer interface [polypeptide binding]; other site 1274814004465 dimer interface [polypeptide binding]; other site 1274814004466 putative active site [active] 1274814004467 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 1274814004468 MoaE interaction surface [polypeptide binding]; other site 1274814004469 MoeB interaction surface [polypeptide binding]; other site 1274814004470 thiocarboxylated glycine; other site 1274814004471 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 1274814004472 MoaE homodimer interface [polypeptide binding]; other site 1274814004473 MoaD interaction [polypeptide binding]; other site 1274814004474 active site residues [active] 1274814004475 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1274814004476 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1274814004477 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1274814004478 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 1274814004479 Predicted integral membrane protein [Function unknown]; Region: COG0392 1274814004480 cardiolipin synthase 2; Provisional; Region: PRK11263 1274814004481 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 1274814004482 putative active site [active] 1274814004483 catalytic site [active] 1274814004484 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 1274814004485 putative active site [active] 1274814004486 catalytic site [active] 1274814004487 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 1274814004488 putative catalytic site [active] 1274814004489 putative metal binding site [ion binding]; other site 1274814004490 putative phosphate binding site [ion binding]; other site 1274814004491 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 1274814004492 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1274814004493 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1274814004494 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1274814004495 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1274814004496 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 1274814004497 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1274814004498 Walker A/P-loop; other site 1274814004499 ATP binding site [chemical binding]; other site 1274814004500 Q-loop/lid; other site 1274814004501 ABC transporter signature motif; other site 1274814004502 Walker B; other site 1274814004503 D-loop; other site 1274814004504 H-loop/switch region; other site 1274814004505 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 1274814004506 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1274814004507 Walker A/P-loop; other site 1274814004508 ATP binding site [chemical binding]; other site 1274814004509 Q-loop/lid; other site 1274814004510 ABC transporter signature motif; other site 1274814004511 Walker B; other site 1274814004512 D-loop; other site 1274814004513 H-loop/switch region; other site 1274814004514 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 1274814004515 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1274814004516 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814004517 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 1274814004518 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 1274814004519 helicase 45; Provisional; Region: PTZ00424 1274814004520 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1274814004521 ATP binding site [chemical binding]; other site 1274814004522 Mg++ binding site [ion binding]; other site 1274814004523 motif III; other site 1274814004524 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1274814004525 nucleotide binding region [chemical binding]; other site 1274814004526 ATP-binding site [chemical binding]; other site 1274814004527 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 1274814004528 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 1274814004529 DEAD_2; Region: DEAD_2; pfam06733 1274814004530 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1274814004531 glycosyl transferase family protein; Provisional; Region: PRK08136 1274814004532 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1274814004533 putative dehydrogenase; Provisional; Region: PRK10098 1274814004534 hypothetical protein; Provisional; Region: PRK10259 1274814004535 hypothetical protein; Provisional; Region: PRK11019 1274814004536 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 1274814004537 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 1274814004538 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1274814004539 N-terminal plug; other site 1274814004540 ligand-binding site [chemical binding]; other site 1274814004541 hypothetical protein; Provisional; Region: PRK10259 1274814004542 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 1274814004543 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 1274814004544 putative mechanosensitive channel protein; Provisional; Region: PRK11465 1274814004545 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1274814004546 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 1274814004547 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1274814004548 Walker A/P-loop; other site 1274814004549 ATP binding site [chemical binding]; other site 1274814004550 Q-loop/lid; other site 1274814004551 ABC transporter signature motif; other site 1274814004552 Walker B; other site 1274814004553 D-loop; other site 1274814004554 H-loop/switch region; other site 1274814004555 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1274814004556 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814004557 dimer interface [polypeptide binding]; other site 1274814004558 conserved gate region; other site 1274814004559 putative PBP binding loops; other site 1274814004560 ABC-ATPase subunit interface; other site 1274814004561 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 1274814004562 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814004563 substrate binding pocket [chemical binding]; other site 1274814004564 membrane-bound complex binding site; other site 1274814004565 hinge residues; other site 1274814004566 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 1274814004567 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 1274814004568 dimerization interface [polypeptide binding]; other site 1274814004569 DPS ferroxidase diiron center [ion binding]; other site 1274814004570 ion pore; other site 1274814004571 threonine and homoserine efflux system; Provisional; Region: PRK10532 1274814004572 EamA-like transporter family; Region: EamA; pfam00892 1274814004573 outer membrane protein X; Provisional; Region: ompX; PRK09408 1274814004574 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1274814004575 Sulfatase; Region: Sulfatase; pfam00884 1274814004576 manganese transport regulator MntR; Provisional; Region: PRK11050 1274814004577 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1274814004578 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 1274814004579 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1274814004580 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 1274814004581 transmembrane helices; other site 1274814004582 L,D-transpeptidase; Provisional; Region: PRK10260 1274814004583 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1274814004584 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 1274814004585 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814004586 Walker A/P-loop; other site 1274814004587 ATP binding site [chemical binding]; other site 1274814004588 Q-loop/lid; other site 1274814004589 ABC transporter signature motif; other site 1274814004590 Walker B; other site 1274814004591 D-loop; other site 1274814004592 H-loop/switch region; other site 1274814004593 ABC transporter; Region: ABC_tran_2; pfam12848 1274814004594 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1274814004595 Protein of unknown function (DUF1479); Region: DUF1479; pfam07350 1274814004596 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 1274814004597 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814004598 active site 1274814004599 motif I; other site 1274814004600 motif II; other site 1274814004601 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814004602 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 1274814004603 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 1274814004604 dimer interface [polypeptide binding]; other site 1274814004605 active site 1274814004606 glycine loop; other site 1274814004607 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 1274814004608 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 1274814004609 active site 1274814004610 intersubunit interactions; other site 1274814004611 catalytic residue [active] 1274814004612 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 1274814004613 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 1274814004614 ATP binding site [chemical binding]; other site 1274814004615 substrate interface [chemical binding]; other site 1274814004616 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 1274814004617 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 1274814004618 dimer interface [polypeptide binding]; other site 1274814004619 putative functional site; other site 1274814004620 putative MPT binding site; other site 1274814004621 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 1274814004622 catalytic nucleophile [active] 1274814004623 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 1274814004624 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814004625 Walker A/P-loop; other site 1274814004626 ATP binding site [chemical binding]; other site 1274814004627 Q-loop/lid; other site 1274814004628 ABC transporter signature motif; other site 1274814004629 Walker B; other site 1274814004630 D-loop; other site 1274814004631 H-loop/switch region; other site 1274814004632 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1274814004633 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814004634 Walker A/P-loop; other site 1274814004635 ATP binding site [chemical binding]; other site 1274814004636 Q-loop/lid; other site 1274814004637 ABC transporter signature motif; other site 1274814004638 Walker B; other site 1274814004639 D-loop; other site 1274814004640 H-loop/switch region; other site 1274814004641 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1274814004642 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 1274814004643 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 1274814004644 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 1274814004645 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814004646 dimer interface [polypeptide binding]; other site 1274814004647 conserved gate region; other site 1274814004648 putative PBP binding loops; other site 1274814004649 ABC-ATPase subunit interface; other site 1274814004650 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 1274814004651 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1274814004652 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814004653 dimer interface [polypeptide binding]; other site 1274814004654 conserved gate region; other site 1274814004655 putative PBP binding loops; other site 1274814004656 ABC-ATPase subunit interface; other site 1274814004657 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814004658 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1274814004659 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814004660 metal binding site [ion binding]; metal-binding site 1274814004661 active site 1274814004662 I-site; other site 1274814004663 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 1274814004664 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 1274814004665 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814004666 FeS/SAM binding site; other site 1274814004667 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 1274814004668 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 1274814004669 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 1274814004670 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1274814004671 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 1274814004672 putative C-terminal domain interface [polypeptide binding]; other site 1274814004673 putative GSH binding site (G-site) [chemical binding]; other site 1274814004674 putative dimer interface [polypeptide binding]; other site 1274814004675 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 1274814004676 N-terminal domain interface [polypeptide binding]; other site 1274814004677 dimer interface [polypeptide binding]; other site 1274814004678 substrate binding pocket (H-site) [chemical binding]; other site 1274814004679 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 1274814004680 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1274814004681 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 1274814004682 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 1274814004683 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1274814004684 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1274814004685 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 1274814004686 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1274814004687 active site 1274814004688 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 1274814004689 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814004690 putative substrate translocation pore; other site 1274814004691 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 1274814004692 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814004693 active site 1274814004694 motif I; other site 1274814004695 motif II; other site 1274814004696 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814004697 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1274814004698 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814004699 putative substrate translocation pore; other site 1274814004700 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1274814004701 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 1274814004702 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1274814004703 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 1274814004704 integrase; Provisional; Region: int; PHA02601 1274814004705 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1274814004706 active site 1274814004707 DNA binding site [nucleotide binding] 1274814004708 Int/Topo IB signature motif; other site 1274814004709 hypothetical protein; Provisional; Region: PRK10040 1274814004710 Predicted transcriptional regulator [Transcription]; Region: COG2932 1274814004711 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 1274814004712 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1274814004713 Catalytic site [active] 1274814004714 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 1274814004715 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 1274814004716 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1274814004717 DksA-like zinc finger domain containing protein; Region: PHA00080 1274814004718 DNA adenine methylase (dam); Region: dam; TIGR00571 1274814004719 Herpesvirus large structural phosphoprotein UL32; Region: Herpes_UL32; pfam06070 1274814004720 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1274814004721 DinI-like family; Region: DinI; pfam06183 1274814004722 MTH538 TIR-like domain (DUF1863); Region: DUF1863; pfam08937 1274814004723 Phage-related protein [Function unknown]; Region: COG4695; cl01923 1274814004724 Phage-related tail protein [Function unknown]; Region: COG5283 1274814004725 Phage protein U [General function prediction only]; Region: COG3499 1274814004726 tail protein; Provisional; Region: D; PHA02561 1274814004727 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 1274814004728 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1274814004729 putative transporter; Provisional; Region: PRK04972 1274814004730 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1274814004731 TrkA-C domain; Region: TrkA_C; pfam02080 1274814004732 TrkA-C domain; Region: TrkA_C; pfam02080 1274814004733 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1274814004734 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 1274814004735 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 1274814004736 GSH binding site [chemical binding]; other site 1274814004737 catalytic residues [active] 1274814004738 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 1274814004739 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 1274814004740 dimer interface [polypeptide binding]; other site 1274814004741 FMN binding site [chemical binding]; other site 1274814004742 NADPH bind site [chemical binding]; other site 1274814004743 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 1274814004744 RimK-like ATP-grasp domain; Region: RimK; pfam08443 1274814004745 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 1274814004746 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 1274814004747 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1274814004748 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 1274814004749 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814004750 Walker A/P-loop; other site 1274814004751 ATP binding site [chemical binding]; other site 1274814004752 Q-loop/lid; other site 1274814004753 ABC transporter signature motif; other site 1274814004754 Walker B; other site 1274814004755 D-loop; other site 1274814004756 H-loop/switch region; other site 1274814004757 TOBE domain; Region: TOBE_2; pfam08402 1274814004758 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1274814004759 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814004760 dimer interface [polypeptide binding]; other site 1274814004761 conserved gate region; other site 1274814004762 putative PBP binding loops; other site 1274814004763 ABC-ATPase subunit interface; other site 1274814004764 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1274814004765 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814004766 dimer interface [polypeptide binding]; other site 1274814004767 conserved gate region; other site 1274814004768 putative PBP binding loops; other site 1274814004769 ABC-ATPase subunit interface; other site 1274814004770 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 1274814004771 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 1274814004772 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814004773 S-adenosylmethionine binding site [chemical binding]; other site 1274814004774 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1274814004775 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814004776 substrate binding pocket [chemical binding]; other site 1274814004777 membrane-bound complex binding site; other site 1274814004778 hinge residues; other site 1274814004779 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814004780 dimer interface [polypeptide binding]; other site 1274814004781 conserved gate region; other site 1274814004782 putative PBP binding loops; other site 1274814004783 ABC-ATPase subunit interface; other site 1274814004784 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1274814004785 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814004786 dimer interface [polypeptide binding]; other site 1274814004787 conserved gate region; other site 1274814004788 putative PBP binding loops; other site 1274814004789 ABC-ATPase subunit interface; other site 1274814004790 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 1274814004791 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814004792 substrate binding pocket [chemical binding]; other site 1274814004793 membrane-bound complex binding site; other site 1274814004794 hinge residues; other site 1274814004795 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 1274814004796 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814004797 Walker A/P-loop; other site 1274814004798 ATP binding site [chemical binding]; other site 1274814004799 Q-loop/lid; other site 1274814004800 ABC transporter signature motif; other site 1274814004801 Walker B; other site 1274814004802 D-loop; other site 1274814004803 H-loop/switch region; other site 1274814004804 putative lipoprotein; Provisional; Region: PRK10533 1274814004805 hypothetical protein; Provisional; Region: PRK02877 1274814004806 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 1274814004807 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 1274814004808 amidase catalytic site [active] 1274814004809 Zn binding residues [ion binding]; other site 1274814004810 substrate binding site [chemical binding]; other site 1274814004811 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1274814004812 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1274814004813 NAD(P) binding site [chemical binding]; other site 1274814004814 active site 1274814004815 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 1274814004816 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 1274814004817 putative NAD(P) binding site [chemical binding]; other site 1274814004818 putative active site [active] 1274814004819 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 1274814004820 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 1274814004821 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 1274814004822 tetramer interface [polypeptide binding]; other site 1274814004823 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814004824 catalytic residue [active] 1274814004825 pyruvate dehydrogenase; Provisional; Region: PRK09124 1274814004826 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 1274814004827 PYR/PP interface [polypeptide binding]; other site 1274814004828 dimer interface [polypeptide binding]; other site 1274814004829 tetramer interface [polypeptide binding]; other site 1274814004830 TPP binding site [chemical binding]; other site 1274814004831 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1274814004832 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 1274814004833 TPP-binding site [chemical binding]; other site 1274814004834 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 1274814004835 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 1274814004836 FAD binding pocket [chemical binding]; other site 1274814004837 FAD binding motif [chemical binding]; other site 1274814004838 phosphate binding motif [ion binding]; other site 1274814004839 beta-alpha-beta structure motif; other site 1274814004840 NAD binding pocket [chemical binding]; other site 1274814004841 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1274814004842 catalytic loop [active] 1274814004843 iron binding site [ion binding]; other site 1274814004844 hybrid cluster protein; Provisional; Region: PRK05290 1274814004845 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1274814004846 ACS interaction site; other site 1274814004847 CODH interaction site; other site 1274814004848 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 1274814004849 hybrid metal cluster; other site 1274814004850 Predicted membrane protein [Function unknown]; Region: COG2431 1274814004851 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 1274814004852 amphipathic channel; other site 1274814004853 Asn-Pro-Ala signature motifs; other site 1274814004854 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 1274814004855 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 1274814004856 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 1274814004857 putative active site [active] 1274814004858 putative metal-binding site [ion binding]; other site 1274814004859 Protein of unknown function (DUF535); Region: DUF535; pfam04393 1274814004860 macrolide transporter subunit MacA; Provisional; Region: PRK11578 1274814004861 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1274814004862 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814004863 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 1274814004864 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1274814004865 Walker A/P-loop; other site 1274814004866 ATP binding site [chemical binding]; other site 1274814004867 Q-loop/lid; other site 1274814004868 ABC transporter signature motif; other site 1274814004869 Walker B; other site 1274814004870 D-loop; other site 1274814004871 H-loop/switch region; other site 1274814004872 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1274814004873 FtsX-like permease family; Region: FtsX; pfam02687 1274814004874 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1274814004875 DNA-binding site [nucleotide binding]; DNA binding site 1274814004876 RNA-binding motif; other site 1274814004877 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 1274814004878 ATP-dependent Clp protease ATP-binding subunit; Provisional; Region: clpA; PRK11034 1274814004879 Clp amino terminal domain; Region: Clp_N; pfam02861 1274814004880 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814004881 Walker A motif; other site 1274814004882 ATP binding site [chemical binding]; other site 1274814004883 Walker B motif; other site 1274814004884 arginine finger; other site 1274814004885 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814004886 Walker A motif; other site 1274814004887 ATP binding site [chemical binding]; other site 1274814004888 Walker B motif; other site 1274814004889 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1274814004890 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 1274814004891 rRNA binding site [nucleotide binding]; other site 1274814004892 predicted 30S ribosome binding site; other site 1274814004893 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 1274814004894 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 1274814004895 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1274814004896 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 1274814004897 Walker A/P-loop; other site 1274814004898 ATP binding site [chemical binding]; other site 1274814004899 Q-loop/lid; other site 1274814004900 ABC transporter signature motif; other site 1274814004901 Walker B; other site 1274814004902 D-loop; other site 1274814004903 H-loop/switch region; other site 1274814004904 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 1274814004905 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1274814004906 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814004907 Walker A/P-loop; other site 1274814004908 ATP binding site [chemical binding]; other site 1274814004909 Q-loop/lid; other site 1274814004910 ABC transporter signature motif; other site 1274814004911 Walker B; other site 1274814004912 D-loop; other site 1274814004913 H-loop/switch region; other site 1274814004914 thioredoxin reductase; Provisional; Region: PRK10262 1274814004915 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1274814004916 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1274814004917 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 1274814004918 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1274814004919 putative DNA binding site [nucleotide binding]; other site 1274814004920 putative Zn2+ binding site [ion binding]; other site 1274814004921 AsnC family; Region: AsnC_trans_reg; pfam01037 1274814004922 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 1274814004923 DNA translocase FtsK; Provisional; Region: PRK10263 1274814004924 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 1274814004925 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 1274814004926 periplasmic chaperone LolA; Region: lolA; TIGR00547 1274814004927 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 1274814004928 recombination factor protein RarA; Reviewed; Region: PRK13342 1274814004929 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814004930 Walker A motif; other site 1274814004931 ATP binding site [chemical binding]; other site 1274814004932 Walker B motif; other site 1274814004933 arginine finger; other site 1274814004934 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 1274814004935 seryl-tRNA synthetase; Provisional; Region: PRK05431 1274814004936 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 1274814004937 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 1274814004938 dimer interface [polypeptide binding]; other site 1274814004939 active site 1274814004940 motif 1; other site 1274814004941 motif 2; other site 1274814004942 motif 3; other site 1274814004943 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 1274814004944 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1274814004945 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1274814004946 putative [Fe4-S4] binding site [ion binding]; other site 1274814004947 putative molybdopterin cofactor binding site [chemical binding]; other site 1274814004948 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1274814004949 putative molybdopterin cofactor binding site; other site 1274814004950 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1274814004951 4Fe-4S binding domain; Region: Fer4; pfam00037 1274814004952 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1274814004953 Isochorismatase family; Region: Isochorismatase; pfam00857 1274814004954 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 1274814004955 catalytic triad [active] 1274814004956 dimer interface [polypeptide binding]; other site 1274814004957 conserved cis-peptide bond; other site 1274814004958 putative MFS family transporter protein; Provisional; Region: PRK03633 1274814004959 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814004960 putative substrate translocation pore; other site 1274814004961 Amino acid permease; Region: AA_permease_2; pfam13520 1274814004962 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1274814004963 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814004964 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1274814004965 putative effector binding pocket; other site 1274814004966 putative dimerization interface [polypeptide binding]; other site 1274814004967 hypothetical protein; Provisional; Region: PRK09739 1274814004968 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1274814004969 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 1274814004970 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814004971 FeS/SAM binding site; other site 1274814004972 integrase; Provisional; Region: int; PHA02601 1274814004973 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1274814004974 active site 1274814004975 DNA binding site [nucleotide binding] 1274814004976 Int/Topo IB signature motif; other site 1274814004977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814004978 sequence-specific DNA binding site [nucleotide binding]; other site 1274814004979 salt bridge; other site 1274814004980 Regulatory phage protein cox; Region: Phage_Cox; pfam10743 1274814004981 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 1274814004982 DksA-like zinc finger domain containing protein; Region: PHA00080 1274814004983 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 1274814004984 Domain of Unknown Function with PDB structure (DUF3850); Region: DUF3850; pfam12961 1274814004985 portal vertex protein; Provisional; Region: Q; PHA02536 1274814004986 Phage portal protein; Region: Phage_portal; pfam04860 1274814004987 terminase ATPase subunit; Provisional; Region: P; PHA02535 1274814004988 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 1274814004989 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 1274814004990 Phage major capsid protein, P2 family; Region: Phage_cap_P2; pfam05125 1274814004991 terminase endonuclease subunit; Provisional; Region: M; PHA02537 1274814004992 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 1274814004993 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 1274814004994 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 1274814004995 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 1274814004996 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 1274814004997 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 1274814004998 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 1274814004999 Baseplate J-like protein; Region: Baseplate_J; cl01294 1274814005000 phage tail protein, P2 protein I family; Region: tail_P2_I; TIGR01634 1274814005001 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 1274814005002 YfdX protein; Region: YfdX; pfam10938 1274814005003 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1274814005004 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1274814005005 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1274814005006 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 1274814005007 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1274814005008 Protein of unknown function (DUF3606); Region: DUF3606; pfam12244 1274814005009 major tail sheath protein; Provisional; Region: FI; PHA02560 1274814005010 major tail tube protein; Provisional; Region: FII; PHA02600 1274814005011 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 1274814005012 Phage P2 GpE; Region: Phage_P2_GpE; pfam06528 1274814005013 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 1274814005014 Phage P2 GpU; Region: Phage_P2_GpU; pfam06995 1274814005015 tail protein; Provisional; Region: D; PHA02561 1274814005016 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 1274814005017 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 1274814005018 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1274814005019 Pyruvate formate lyase 1; Region: PFL1; cd01678 1274814005020 coenzyme A binding site [chemical binding]; other site 1274814005021 active site 1274814005022 catalytic residues [active] 1274814005023 glycine loop; other site 1274814005024 formate transporter; Provisional; Region: PRK10805 1274814005025 uncharacterized domain; Region: TIGR00702 1274814005026 YcaO-like family; Region: YcaO; pfam02624 1274814005027 Predicted membrane protein [Function unknown]; Region: COG2323 1274814005028 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 1274814005029 homodimer interface [polypeptide binding]; other site 1274814005030 substrate-cofactor binding pocket; other site 1274814005031 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814005032 catalytic residue [active] 1274814005033 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 1274814005034 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 1274814005035 hinge; other site 1274814005036 active site 1274814005037 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1274814005038 cytidylate kinase; Provisional; Region: cmk; PRK00023 1274814005039 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 1274814005040 CMP-binding site; other site 1274814005041 The sites determining sugar specificity; other site 1274814005042 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 1274814005043 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 1274814005044 RNA binding site [nucleotide binding]; other site 1274814005045 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 1274814005046 RNA binding site [nucleotide binding]; other site 1274814005047 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 1274814005048 RNA binding site [nucleotide binding]; other site 1274814005049 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 1274814005050 RNA binding site [nucleotide binding]; other site 1274814005051 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 1274814005052 RNA binding site [nucleotide binding]; other site 1274814005053 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1274814005054 IHF dimer interface [polypeptide binding]; other site 1274814005055 IHF - DNA interface [nucleotide binding]; other site 1274814005056 ComEC family competence protein; Provisional; Region: PRK11539 1274814005057 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 1274814005058 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 1274814005059 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 1274814005060 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 1274814005061 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 1274814005062 Walker A/P-loop; other site 1274814005063 ATP binding site [chemical binding]; other site 1274814005064 Q-loop/lid; other site 1274814005065 ABC transporter signature motif; other site 1274814005066 Walker B; other site 1274814005067 D-loop; other site 1274814005068 H-loop/switch region; other site 1274814005069 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 1274814005070 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 1274814005071 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 1274814005072 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 1274814005073 hypothetical protein; Provisional; Region: PRK11827 1274814005074 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 1274814005075 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 1274814005076 Ligand binding site; other site 1274814005077 oligomer interface; other site 1274814005078 hypothetical protein; Provisional; Region: PRK10593 1274814005079 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1274814005080 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1274814005081 putative active site [active] 1274814005082 Methyltransferase domain; Region: Methyltransf_31; pfam13847 1274814005083 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814005084 S-adenosylmethionine binding site [chemical binding]; other site 1274814005085 condesin subunit F; Provisional; Region: PRK05260 1274814005086 condesin subunit E; Provisional; Region: PRK05256 1274814005087 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 1274814005088 MukB N-terminal; Region: MukB; pfam04310 1274814005089 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 1274814005090 murein L,D-transpeptidase; Provisional; Region: PRK10594 1274814005091 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1274814005092 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1274814005093 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1274814005094 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 1274814005095 Peptidase M15; Region: Peptidase_M15_3; cl01194 1274814005096 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 1274814005097 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814005098 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 1274814005099 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1274814005100 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814005101 homodimer interface [polypeptide binding]; other site 1274814005102 catalytic residue [active] 1274814005103 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1274814005104 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1274814005105 trimer interface [polypeptide binding]; other site 1274814005106 eyelet of channel; other site 1274814005107 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 1274814005108 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 1274814005109 putative dimer interface [polypeptide binding]; other site 1274814005110 putative anticodon binding site; other site 1274814005111 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 1274814005112 homodimer interface [polypeptide binding]; other site 1274814005113 motif 1; other site 1274814005114 motif 2; other site 1274814005115 active site 1274814005116 motif 3; other site 1274814005117 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 1274814005118 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 1274814005119 active site 1274814005120 aminopeptidase N; Provisional; Region: pepN; PRK14015 1274814005121 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 1274814005122 active site 1274814005123 Zn binding site [ion binding]; other site 1274814005124 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 1274814005125 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 1274814005126 Walker A/P-loop; other site 1274814005127 ATP binding site [chemical binding]; other site 1274814005128 Q-loop/lid; other site 1274814005129 ABC transporter signature motif; other site 1274814005130 Walker B; other site 1274814005131 D-loop; other site 1274814005132 H-loop/switch region; other site 1274814005133 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1274814005134 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814005135 dimer interface [polypeptide binding]; other site 1274814005136 conserved gate region; other site 1274814005137 putative PBP binding loops; other site 1274814005138 ABC-ATPase subunit interface; other site 1274814005139 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 1274814005140 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1274814005141 active site 1274814005142 dimer interface [polypeptide binding]; other site 1274814005143 non-prolyl cis peptide bond; other site 1274814005144 insertion regions; other site 1274814005145 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814005146 substrate binding pocket [chemical binding]; other site 1274814005147 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 1274814005148 membrane-bound complex binding site; other site 1274814005149 hinge residues; other site 1274814005150 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 1274814005151 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1274814005152 Fimbrial protein; Region: Fimbrial; cl01416 1274814005153 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1274814005154 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1274814005155 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1274814005156 outer membrane usher protein; Provisional; Region: PRK15193 1274814005157 PapC N-terminal domain; Region: PapC_N; pfam13954 1274814005158 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1274814005159 PapC C-terminal domain; Region: PapC_C; pfam13953 1274814005160 Fimbrial protein; Region: Fimbrial; cl01416 1274814005161 Fimbrial protein; Region: Fimbrial; cl01416 1274814005162 Fimbrial protein; Region: Fimbrial; cl01416 1274814005163 putativi pili assembly chaperone; Provisional; Region: PRK11385 1274814005164 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1274814005165 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1274814005166 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 1274814005167 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 1274814005168 quinone interaction residues [chemical binding]; other site 1274814005169 active site 1274814005170 catalytic residues [active] 1274814005171 FMN binding site [chemical binding]; other site 1274814005172 substrate binding site [chemical binding]; other site 1274814005173 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 1274814005174 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 1274814005175 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 1274814005176 MOSC domain; Region: MOSC; pfam03473 1274814005177 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1274814005178 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1274814005179 catalytic loop [active] 1274814005180 iron binding site [ion binding]; other site 1274814005181 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 1274814005182 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 1274814005183 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 1274814005184 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814005185 S-adenosylmethionine binding site [chemical binding]; other site 1274814005186 ABC transporter ATPase component; Reviewed; Region: PRK11147 1274814005187 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814005188 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814005189 Walker A/P-loop; other site 1274814005190 Walker A/P-loop; other site 1274814005191 ATP binding site [chemical binding]; other site 1274814005192 ATP binding site [chemical binding]; other site 1274814005193 Q-loop/lid; other site 1274814005194 Q-loop/lid; other site 1274814005195 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1274814005196 ABC transporter signature motif; other site 1274814005197 Walker B; other site 1274814005198 D-loop; other site 1274814005199 ABC transporter; Region: ABC_tran_2; pfam12848 1274814005200 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1274814005201 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 1274814005202 Paraquat-inducible protein A; Region: PqiA; pfam04403 1274814005203 Paraquat-inducible protein A; Region: PqiA; pfam04403 1274814005204 paraquat-inducible protein B; Provisional; Region: PRK10807 1274814005205 mce related protein; Region: MCE; pfam02470 1274814005206 mce related protein; Region: MCE; pfam02470 1274814005207 mce related protein; Region: MCE; pfam02470 1274814005208 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 1274814005209 Protein of unknown function (DUF330); Region: DUF330; pfam03886 1274814005210 ribosome modulation factor; Provisional; Region: PRK14563 1274814005211 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 1274814005212 active site 1 [active] 1274814005213 dimer interface [polypeptide binding]; other site 1274814005214 active site 2 [active] 1274814005215 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 1274814005216 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 1274814005217 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 1274814005218 outer membrane protein A; Reviewed; Region: PRK10808 1274814005219 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 1274814005220 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1274814005221 ligand binding site [chemical binding]; other site 1274814005222 cell division inhibitor SulA; Region: sula; TIGR00623 1274814005223 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 1274814005224 TfoX C-terminal domain; Region: TfoX_C; pfam04994 1274814005225 TIGR01666 family membrane protein; Region: YCCS 1274814005226 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1274814005227 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1274814005228 Predicted membrane protein [Function unknown]; Region: COG3304 1274814005229 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1274814005230 Domain of unknown function (DUF307); Region: DUF307; pfam03733 1274814005231 DNA helicase IV; Provisional; Region: helD; PRK11054 1274814005232 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 1274814005233 Part of AAA domain; Region: AAA_19; pfam13245 1274814005234 Family description; Region: UvrD_C_2; pfam13538 1274814005235 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 1274814005236 active site 1274814005237 dimer interfaces [polypeptide binding]; other site 1274814005238 catalytic residues [active] 1274814005239 hypothetical protein; Provisional; Region: PRK03641 1274814005240 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 1274814005241 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 1274814005242 heat shock protein HspQ; Provisional; Region: PRK14129 1274814005243 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 1274814005244 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 1274814005245 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 1274814005246 putative RNA binding site [nucleotide binding]; other site 1274814005247 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814005248 S-adenosylmethionine binding site [chemical binding]; other site 1274814005249 Acylphosphatase; Region: Acylphosphatase; cl00551 1274814005250 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 1274814005251 sulfur transfer protein TusE; Provisional; Region: PRK11508 1274814005252 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 1274814005253 YccA-like proteins; Region: YccA_like; cd10433 1274814005254 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 1274814005255 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1274814005256 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1274814005257 hydrogenase 1 large subunit; Provisional; Region: PRK10170 1274814005258 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1274814005259 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 1274814005260 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1274814005261 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1274814005262 putative substrate-binding site; other site 1274814005263 nickel binding site [ion binding]; other site 1274814005264 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 1274814005265 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 1274814005266 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 1274814005267 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 1274814005268 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 1274814005269 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 1274814005270 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 1274814005271 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1274814005272 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1274814005273 catalytic core [active] 1274814005274 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1274814005275 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 1274814005276 Chain length determinant protein; Region: Wzz; pfam02706 1274814005277 Chain length determinant protein; Region: Wzz; cl15801 1274814005278 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1274814005279 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 1274814005280 Nucleotide binding site [chemical binding]; other site 1274814005281 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1274814005282 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1274814005283 active site 1274814005284 polysaccharide export protein Wza; Provisional; Region: PRK15078 1274814005285 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1274814005286 SLBB domain; Region: SLBB; pfam10531 1274814005287 SLBB domain; Region: SLBB; pfam10531 1274814005288 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 1274814005289 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 1274814005290 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 1274814005291 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1274814005292 DNA-binding site [nucleotide binding]; DNA binding site 1274814005293 RNA-binding motif; other site 1274814005294 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1274814005295 DNA-binding site [nucleotide binding]; DNA binding site 1274814005296 RNA-binding motif; other site 1274814005297 cold shock gene; Provisional; Region: PRK09891 1274814005298 GnsA/GnsB family; Region: GnsAB; pfam08178 1274814005299 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1274814005300 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1274814005301 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1274814005302 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1274814005303 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 1274814005304 HAMP domain; Region: HAMP; pfam00672 1274814005305 dimerization interface [polypeptide binding]; other site 1274814005306 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814005307 dimer interface [polypeptide binding]; other site 1274814005308 phosphorylation site [posttranslational modification] 1274814005309 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814005310 ATP binding site [chemical binding]; other site 1274814005311 Mg2+ binding site [ion binding]; other site 1274814005312 G-X-G motif; other site 1274814005313 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814005314 active site 1274814005315 phosphorylation site [posttranslational modification] 1274814005316 intermolecular recognition site; other site 1274814005317 dimerization interface [polypeptide binding]; other site 1274814005318 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1274814005319 putative binding surface; other site 1274814005320 active site 1274814005321 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 1274814005322 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 1274814005323 putative ligand binding site [chemical binding]; other site 1274814005324 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 1274814005325 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814005326 active site 1274814005327 phosphorylation site [posttranslational modification] 1274814005328 intermolecular recognition site; other site 1274814005329 dimerization interface [polypeptide binding]; other site 1274814005330 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814005331 DNA binding site [nucleotide binding] 1274814005332 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 1274814005333 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1274814005334 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 1274814005335 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1274814005336 molybdopterin cofactor binding site [chemical binding]; other site 1274814005337 substrate binding site [chemical binding]; other site 1274814005338 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1274814005339 molybdopterin cofactor binding site; other site 1274814005340 chaperone protein TorD; Validated; Region: torD; PRK04976 1274814005341 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 1274814005342 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 1274814005343 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 1274814005344 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1274814005345 HSP70 interaction site [polypeptide binding]; other site 1274814005346 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 1274814005347 substrate binding site [polypeptide binding]; other site 1274814005348 dimer interface [polypeptide binding]; other site 1274814005349 hypothetical protein; Provisional; Region: PRK09784 1274814005350 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 1274814005351 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1274814005352 catalytic core [active] 1274814005353 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 1274814005354 hypothetical protein; Provisional; Region: PRK10174 1274814005355 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 1274814005356 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1274814005357 General stress protein [General function prediction only]; Region: GsiB; COG3729 1274814005358 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 1274814005359 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 1274814005360 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 1274814005361 putative FMN binding site [chemical binding]; other site 1274814005362 pyrimidine utilization protein D; Region: RutD; TIGR03611 1274814005363 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1274814005364 homotrimer interaction site [polypeptide binding]; other site 1274814005365 putative active site [active] 1274814005366 Isochorismatase family; Region: Isochorismatase; pfam00857 1274814005367 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1274814005368 catalytic triad [active] 1274814005369 conserved cis-peptide bond; other site 1274814005370 pyrimidine utilization protein A; Region: RutA; TIGR03612 1274814005371 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 1274814005372 active site 1274814005373 dimer interface [polypeptide binding]; other site 1274814005374 non-prolyl cis peptide bond; other site 1274814005375 insertion regions; other site 1274814005376 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1274814005377 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 1274814005378 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1274814005379 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 1274814005380 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 1274814005381 Predicted transcriptional regulator [Transcription]; Region: COG3905 1274814005382 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 1274814005383 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 1274814005384 Glutamate binding site [chemical binding]; other site 1274814005385 NAD binding site [chemical binding]; other site 1274814005386 catalytic residues [active] 1274814005387 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 1274814005388 Na binding site [ion binding]; other site 1274814005389 FTR1 family protein; Region: TIGR00145 1274814005390 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 1274814005391 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 1274814005392 Imelysin; Region: Peptidase_M75; pfam09375 1274814005393 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 1274814005394 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 1274814005395 hypothetical protein; Provisional; Region: PRK10536 1274814005396 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 1274814005397 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 1274814005398 N-glycosyltransferase; Provisional; Region: PRK11204 1274814005399 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 1274814005400 DXD motif; other site 1274814005401 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 1274814005402 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 1274814005403 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 1274814005404 putative active site [active] 1274814005405 putative metal binding site [ion binding]; other site 1274814005406 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 1274814005407 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1274814005408 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814005409 metal binding site [ion binding]; metal-binding site 1274814005410 active site 1274814005411 I-site; other site 1274814005412 putative transposase OrfB; Reviewed; Region: PHA02517 1274814005413 HTH-like domain; Region: HTH_21; pfam13276 1274814005414 Integrase core domain; Region: rve; pfam00665 1274814005415 Integrase core domain; Region: rve_2; pfam13333 1274814005416 Transposase; Region: HTH_Tnp_1; cl17663 1274814005417 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814005418 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1274814005419 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 1274814005420 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 1274814005421 putative ligand binding site [chemical binding]; other site 1274814005422 NAD binding site [chemical binding]; other site 1274814005423 dimerization interface [polypeptide binding]; other site 1274814005424 catalytic site [active] 1274814005425 putative hydrolase; Validated; Region: PRK09248 1274814005426 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 1274814005427 active site 1274814005428 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 1274814005429 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 1274814005430 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 1274814005431 curli assembly protein CsgF; Provisional; Region: PRK10050 1274814005432 curli assembly protein CsgE; Provisional; Region: PRK10386 1274814005433 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 1274814005434 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814005435 DNA binding residues [nucleotide binding] 1274814005436 dimerization interface [polypeptide binding]; other site 1274814005437 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 1274814005438 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1274814005439 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1274814005440 major curlin subunit; Provisional; Region: csgA; PRK10051 1274814005441 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1274814005442 Curlin associated repeat; Region: Curlin_rpt; pfam07012 1274814005443 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 1274814005444 Fimbrial protein; Region: Fimbrial; cl01416 1274814005445 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 1274814005446 putative ADP-ribose binding site [chemical binding]; other site 1274814005447 putative active site [active] 1274814005448 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 1274814005449 PLD-like domain; Region: PLDc_2; pfam13091 1274814005450 putative active site [active] 1274814005451 catalytic site [active] 1274814005452 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 1274814005453 PLD-like domain; Region: PLDc_2; pfam13091 1274814005454 putative active site [active] 1274814005455 catalytic site [active] 1274814005456 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 1274814005457 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1274814005458 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 1274814005459 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 1274814005460 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 1274814005461 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 1274814005462 Ligand binding site; other site 1274814005463 DXD motif; other site 1274814005464 lipoprotein; Provisional; Region: PRK10175 1274814005465 secY/secA suppressor protein; Provisional; Region: PRK11467 1274814005466 drug efflux system protein MdtG; Provisional; Region: PRK09874 1274814005467 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814005468 putative substrate translocation pore; other site 1274814005469 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1274814005470 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1274814005471 putative acyl-acceptor binding pocket; other site 1274814005472 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 1274814005473 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 1274814005474 active site residue [active] 1274814005475 hypothetical protein; Provisional; Region: PRK03757 1274814005476 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1274814005477 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 1274814005478 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 1274814005479 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1274814005480 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 1274814005481 DNA damage-inducible protein I; Provisional; Region: PRK10597 1274814005482 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 1274814005483 active site 1274814005484 substrate binding pocket [chemical binding]; other site 1274814005485 dimer interface [polypeptide binding]; other site 1274814005486 lipoprotein; Provisional; Region: PRK10598 1274814005487 glutaredoxin 2; Provisional; Region: PRK10387 1274814005488 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 1274814005489 C-terminal domain interface [polypeptide binding]; other site 1274814005490 GSH binding site (G-site) [chemical binding]; other site 1274814005491 catalytic residues [active] 1274814005492 putative dimer interface [polypeptide binding]; other site 1274814005493 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 1274814005494 N-terminal domain interface [polypeptide binding]; other site 1274814005495 multidrug resistance protein MdtH; Provisional; Region: PRK11646 1274814005496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814005497 putative substrate translocation pore; other site 1274814005498 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 1274814005499 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1274814005500 hypothetical protein; Provisional; Region: PRK11239 1274814005501 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 1274814005502 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1274814005503 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1274814005504 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1274814005505 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 1274814005506 MviN-like protein; Region: MVIN; pfam03023 1274814005507 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 1274814005508 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 1274814005509 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 1274814005510 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 1274814005511 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 1274814005512 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 1274814005513 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 1274814005514 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 1274814005515 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1274814005516 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1274814005517 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 1274814005518 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 1274814005519 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 1274814005520 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 1274814005521 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1274814005522 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 1274814005523 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1274814005524 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 1274814005525 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1274814005526 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 1274814005527 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 1274814005528 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1274814005529 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 1274814005530 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 1274814005531 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 1274814005532 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 1274814005533 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 1274814005534 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 1274814005535 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 1274814005536 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 1274814005537 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 1274814005538 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 1274814005539 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 1274814005540 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 1274814005541 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1274814005542 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 1274814005543 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1274814005544 homodimer interface [polypeptide binding]; other site 1274814005545 oligonucleotide binding site [chemical binding]; other site 1274814005546 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 1274814005547 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 1274814005548 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1274814005549 RNA binding surface [nucleotide binding]; other site 1274814005550 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1274814005551 active site 1274814005552 Maf-like protein; Region: Maf; pfam02545 1274814005553 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1274814005554 active site 1274814005555 dimer interface [polypeptide binding]; other site 1274814005556 hypothetical protein; Provisional; Region: PRK11193 1274814005557 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 1274814005558 putative phosphate acyltransferase; Provisional; Region: PRK05331 1274814005559 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 1274814005560 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 1274814005561 dimer interface [polypeptide binding]; other site 1274814005562 active site 1274814005563 CoA binding pocket [chemical binding]; other site 1274814005564 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 1274814005565 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 1274814005566 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 1274814005567 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 1274814005568 NAD(P) binding site [chemical binding]; other site 1274814005569 homotetramer interface [polypeptide binding]; other site 1274814005570 homodimer interface [polypeptide binding]; other site 1274814005571 active site 1274814005572 acyl carrier protein; Provisional; Region: acpP; PRK00982 1274814005573 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 1274814005574 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1274814005575 dimer interface [polypeptide binding]; other site 1274814005576 active site 1274814005577 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1274814005578 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 1274814005579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814005580 catalytic residue [active] 1274814005581 conserved hypothetical protein, YceG family; Region: TIGR00247 1274814005582 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 1274814005583 dimerization interface [polypeptide binding]; other site 1274814005584 thymidylate kinase; Validated; Region: tmk; PRK00698 1274814005585 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1274814005586 TMP-binding site; other site 1274814005587 ATP-binding site [chemical binding]; other site 1274814005588 DNA polymerase III subunit delta'; Validated; Region: PRK07993 1274814005589 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 1274814005590 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1274814005591 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 1274814005592 active site 1274814005593 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 1274814005594 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1274814005595 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1274814005596 active site turn [active] 1274814005597 phosphorylation site [posttranslational modification] 1274814005598 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 1274814005599 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1274814005600 N-terminal plug; other site 1274814005601 ligand-binding site [chemical binding]; other site 1274814005602 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 1274814005603 nucleotide binding site/active site [active] 1274814005604 HIT family signature motif; other site 1274814005605 catalytic residue [active] 1274814005606 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 1274814005607 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 1274814005608 putative dimer interface [polypeptide binding]; other site 1274814005609 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 1274814005610 thiamine kinase; Region: ycfN_thiK; TIGR02721 1274814005611 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1274814005612 active site 1274814005613 substrate binding site [chemical binding]; other site 1274814005614 ATP binding site [chemical binding]; other site 1274814005615 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 1274814005616 beta-hexosaminidase; Provisional; Region: PRK05337 1274814005617 hypothetical protein; Provisional; Region: PRK04940 1274814005618 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 1274814005619 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1274814005620 hypothetical protein; Provisional; Region: PRK11280 1274814005621 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1274814005622 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1274814005623 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1274814005624 L,D-transpeptidase; Provisional; Region: PRK10260 1274814005625 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1274814005626 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1274814005627 transcription-repair coupling factor; Provisional; Region: PRK10689 1274814005628 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 1274814005629 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1274814005630 ATP binding site [chemical binding]; other site 1274814005631 putative Mg++ binding site [ion binding]; other site 1274814005632 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1274814005633 nucleotide binding region [chemical binding]; other site 1274814005634 ATP-binding site [chemical binding]; other site 1274814005635 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 1274814005636 Predicted membrane protein [Function unknown]; Region: COG4763 1274814005637 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1274814005638 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 1274814005639 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1274814005640 FtsX-like permease family; Region: FtsX; pfam02687 1274814005641 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 1274814005642 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 1274814005643 Walker A/P-loop; other site 1274814005644 ATP binding site [chemical binding]; other site 1274814005645 Q-loop/lid; other site 1274814005646 ABC transporter signature motif; other site 1274814005647 Walker B; other site 1274814005648 D-loop; other site 1274814005649 H-loop/switch region; other site 1274814005650 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 1274814005651 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 1274814005652 FtsX-like permease family; Region: FtsX; pfam02687 1274814005653 fructokinase; Reviewed; Region: PRK09557 1274814005654 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1274814005655 nucleotide binding site [chemical binding]; other site 1274814005656 NAD-dependent deacetylase; Provisional; Region: PRK00481 1274814005657 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 1274814005658 NAD+ binding site [chemical binding]; other site 1274814005659 substrate binding site [chemical binding]; other site 1274814005660 Zn binding site [ion binding]; other site 1274814005661 Repair protein; Region: Repair_PSII; cl01535 1274814005662 Protein of unknown function (DUF3592); Region: DUF3592; pfam12158 1274814005663 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 1274814005664 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 1274814005665 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1274814005666 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814005667 dimer interface [polypeptide binding]; other site 1274814005668 conserved gate region; other site 1274814005669 putative PBP binding loops; other site 1274814005670 ABC-ATPase subunit interface; other site 1274814005671 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1274814005672 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814005673 dimer interface [polypeptide binding]; other site 1274814005674 conserved gate region; other site 1274814005675 putative PBP binding loops; other site 1274814005676 ABC-ATPase subunit interface; other site 1274814005677 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 1274814005678 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814005679 Walker A/P-loop; other site 1274814005680 ATP binding site [chemical binding]; other site 1274814005681 Q-loop/lid; other site 1274814005682 ABC transporter signature motif; other site 1274814005683 Walker B; other site 1274814005684 D-loop; other site 1274814005685 H-loop/switch region; other site 1274814005686 TOBE domain; Region: TOBE_2; pfam08402 1274814005687 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 1274814005688 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 1274814005689 metal binding site [ion binding]; metal-binding site 1274814005690 dimer interface [polypeptide binding]; other site 1274814005691 Uncharacterized conserved protein [Function unknown]; Region: COG2850 1274814005692 Cupin-like domain; Region: Cupin_8; pfam13621 1274814005693 sensor protein PhoQ; Provisional; Region: PRK10815 1274814005694 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 1274814005695 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 1274814005696 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 1274814005697 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814005698 ATP binding site [chemical binding]; other site 1274814005699 Mg2+ binding site [ion binding]; other site 1274814005700 G-X-G motif; other site 1274814005701 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 1274814005702 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814005703 active site 1274814005704 phosphorylation site [posttranslational modification] 1274814005705 intermolecular recognition site; other site 1274814005706 dimerization interface [polypeptide binding]; other site 1274814005707 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814005708 DNA binding site [nucleotide binding] 1274814005709 adenylosuccinate lyase; Provisional; Region: PRK09285 1274814005710 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 1274814005711 tetramer interface [polypeptide binding]; other site 1274814005712 active site 1274814005713 putative lysogenization regulator; Reviewed; Region: PRK00218 1274814005714 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 1274814005715 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 1274814005716 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 1274814005717 nudix motif; other site 1274814005718 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 1274814005719 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 1274814005720 probable active site [active] 1274814005721 isocitrate dehydrogenase; Validated; Region: PRK07362 1274814005722 isocitrate dehydrogenase; Reviewed; Region: PRK07006 1274814005723 anti-adapter protein IraM; Provisional; Region: PRK09919 1274814005724 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 1274814005725 transcriptional regulator MirA; Provisional; Region: PRK15043 1274814005726 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 1274814005727 DNA binding residues [nucleotide binding] 1274814005728 Sensors of blue-light using FAD; Region: BLUF; smart01034 1274814005729 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814005730 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1274814005731 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 1274814005732 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1274814005733 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814005734 heme ABC transporter, heme-binding protein isdE; Region: IsdE; TIGR03659 1274814005735 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1274814005736 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1274814005737 Autotransporter beta-domain; Region: Autotransporter; smart00869 1274814005738 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1274814005739 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 1274814005740 cell division inhibitor MinD; Provisional; Region: PRK10818 1274814005741 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 1274814005742 Switch I; other site 1274814005743 Switch II; other site 1274814005744 septum formation inhibitor; Reviewed; Region: minC; PRK03511 1274814005745 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 1274814005746 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 1274814005747 IS2 repressor TnpA; Reviewed; Region: PRK09413 1274814005748 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814005749 IS2 transposase TnpB; Reviewed; Region: PRK09409 1274814005750 HTH-like domain; Region: HTH_21; pfam13276 1274814005751 Integrase core domain; Region: rve; pfam00665 1274814005752 Integrase core domain; Region: rve_3; pfam13683 1274814005753 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1274814005754 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 1274814005755 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 1274814005756 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 1274814005757 hypothetical protein; Provisional; Region: PRK10691 1274814005758 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 1274814005759 hypothetical protein; Provisional; Region: PRK05170 1274814005760 Haemolysin E (HlyE); Region: HlyE; cl11627 1274814005761 Haemolysin E (HlyE); Region: HlyE; cl11627 1274814005762 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 1274814005763 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 1274814005764 Catalytic site [active] 1274814005765 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 1274814005766 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 1274814005767 active site 1274814005768 DNA binding site [nucleotide binding] 1274814005769 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 1274814005770 disulfide bond formation protein B; Provisional; Region: PRK01749 1274814005771 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1274814005772 transmembrane helices; other site 1274814005773 fatty acid metabolism regulator; Provisional; Region: PRK04984 1274814005774 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814005775 DNA-binding site [nucleotide binding]; DNA binding site 1274814005776 FadR C-terminal domain; Region: FadR_C; pfam07840 1274814005777 SpoVR family protein; Provisional; Region: PRK11767 1274814005778 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 1274814005779 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 1274814005780 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1274814005781 alanine racemase; Reviewed; Region: dadX; PRK03646 1274814005782 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 1274814005783 active site 1274814005784 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1274814005785 substrate binding site [chemical binding]; other site 1274814005786 catalytic residues [active] 1274814005787 dimer interface [polypeptide binding]; other site 1274814005788 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 1274814005789 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 1274814005790 TrkA-C domain; Region: TrkA_C; pfam02080 1274814005791 Transporter associated domain; Region: CorC_HlyC; smart01091 1274814005792 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 1274814005793 dimer interface [polypeptide binding]; other site 1274814005794 catalytic triad [active] 1274814005795 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 1274814005796 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1274814005797 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1274814005798 catalytic residue [active] 1274814005799 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 1274814005800 Flagellar regulator YcgR; Region: YcgR; pfam07317 1274814005801 PilZ domain; Region: PilZ; pfam07238 1274814005802 hypothetical protein; Provisional; Region: PRK10457 1274814005803 trehalase; Provisional; Region: treA; PRK13271 1274814005804 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 1274814005805 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 1274814005806 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 1274814005807 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1274814005808 dimerization domain swap beta strand [polypeptide binding]; other site 1274814005809 regulatory protein interface [polypeptide binding]; other site 1274814005810 active site 1274814005811 regulatory phosphorylation site [posttranslational modification]; other site 1274814005812 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1274814005813 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1274814005814 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 1274814005815 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 1274814005816 Dak1 domain; Region: Dak1; pfam02733 1274814005817 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 1274814005818 PAS domain; Region: PAS; smart00091 1274814005819 putative active site [active] 1274814005820 heme pocket [chemical binding]; other site 1274814005821 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814005822 Walker A motif; other site 1274814005823 ATP binding site [chemical binding]; other site 1274814005824 Walker B motif; other site 1274814005825 arginine finger; other site 1274814005826 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1274814005827 potential frameshift: common BLAST hit: gi|260867607|ref|YP_003234009.1| putative adhesin 1274814005828 GTP-binding protein YchF; Reviewed; Region: PRK09601 1274814005829 YchF GTPase; Region: YchF; cd01900 1274814005830 G1 box; other site 1274814005831 GTP/Mg2+ binding site [chemical binding]; other site 1274814005832 Switch I region; other site 1274814005833 G2 box; other site 1274814005834 Switch II region; other site 1274814005835 G3 box; other site 1274814005836 G4 box; other site 1274814005837 G5 box; other site 1274814005838 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 1274814005839 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 1274814005840 putative active site [active] 1274814005841 catalytic residue [active] 1274814005842 hypothetical protein; Provisional; Region: PRK10692 1274814005843 putative transporter; Provisional; Region: PRK11660 1274814005844 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 1274814005845 Sulfate transporter family; Region: Sulfate_transp; pfam00916 1274814005846 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 1274814005847 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 1274814005848 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 1274814005849 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1274814005850 active site 1274814005851 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 1274814005852 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 1274814005853 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 1274814005854 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 1274814005855 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 1274814005856 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 1274814005857 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 1274814005858 tRNA; other site 1274814005859 putative tRNA binding site [nucleotide binding]; other site 1274814005860 putative NADP binding site [chemical binding]; other site 1274814005861 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 1274814005862 peptide chain release factor 1; Validated; Region: prfA; PRK00591 1274814005863 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1274814005864 RF-1 domain; Region: RF-1; pfam00472 1274814005865 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 1274814005866 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814005867 hypothetical protein; Provisional; Region: PRK10278 1274814005868 hypothetical protein; Provisional; Region: PRK10941 1274814005869 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 1274814005870 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 1274814005871 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1274814005872 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1274814005873 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1274814005874 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 1274814005875 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1274814005876 cation transport regulator; Reviewed; Region: chaB; PRK09582 1274814005877 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 1274814005878 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 1274814005879 putative active site pocket [active] 1274814005880 dimerization interface [polypeptide binding]; other site 1274814005881 putative catalytic residue [active] 1274814005882 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 1274814005883 putative invasin; Provisional; Region: PRK10177 1274814005884 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1274814005885 transcriptional regulator NarL; Provisional; Region: PRK10651 1274814005886 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814005887 active site 1274814005888 phosphorylation site [posttranslational modification] 1274814005889 intermolecular recognition site; other site 1274814005890 dimerization interface [polypeptide binding]; other site 1274814005891 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814005892 DNA binding residues [nucleotide binding] 1274814005893 dimerization interface [polypeptide binding]; other site 1274814005894 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 1274814005895 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1274814005896 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1274814005897 dimerization interface [polypeptide binding]; other site 1274814005898 Histidine kinase; Region: HisKA_3; pfam07730 1274814005899 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814005900 ATP binding site [chemical binding]; other site 1274814005901 Mg2+ binding site [ion binding]; other site 1274814005902 G-X-G motif; other site 1274814005903 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1274814005904 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 1274814005905 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1274814005906 [4Fe-4S] binding site [ion binding]; other site 1274814005907 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1274814005908 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1274814005909 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1274814005910 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1274814005911 molybdopterin cofactor binding site; other site 1274814005912 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1274814005913 4Fe-4S binding domain; Region: Fer4; cl02805 1274814005914 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 1274814005915 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1274814005916 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 1274814005917 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 1274814005918 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 1274814005919 putative active site [active] 1274814005920 putative substrate binding site [chemical binding]; other site 1274814005921 putative cosubstrate binding site; other site 1274814005922 catalytic site [active] 1274814005923 SEC-C motif; Region: SEC-C; pfam02810 1274814005924 hypothetical protein; Provisional; Region: PRK04233 1274814005925 hypothetical protein; Provisional; Region: PRK10279 1274814005926 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 1274814005927 active site 1274814005928 nucleophile elbow; other site 1274814005929 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814005930 active site 1274814005931 response regulator of RpoS; Provisional; Region: PRK10693 1274814005932 phosphorylation site [posttranslational modification] 1274814005933 intermolecular recognition site; other site 1274814005934 dimerization interface [polypeptide binding]; other site 1274814005935 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1274814005936 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1274814005937 active site 1274814005938 tetramer interface; other site 1274814005939 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 1274814005940 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1274814005941 thymidine kinase; Provisional; Region: PRK04296 1274814005942 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 1274814005943 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 1274814005944 putative catalytic cysteine [active] 1274814005945 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 1274814005946 putative active site [active] 1274814005947 metal binding site [ion binding]; metal-binding site 1274814005948 hypothetical protein; Provisional; Region: PRK11111 1274814005949 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1274814005950 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1274814005951 peptide binding site [polypeptide binding]; other site 1274814005952 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 1274814005953 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814005954 dimer interface [polypeptide binding]; other site 1274814005955 conserved gate region; other site 1274814005956 putative PBP binding loops; other site 1274814005957 ABC-ATPase subunit interface; other site 1274814005958 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 1274814005959 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1274814005960 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814005961 dimer interface [polypeptide binding]; other site 1274814005962 conserved gate region; other site 1274814005963 putative PBP binding loops; other site 1274814005964 ABC-ATPase subunit interface; other site 1274814005965 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 1274814005966 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814005967 Walker A/P-loop; other site 1274814005968 ATP binding site [chemical binding]; other site 1274814005969 Q-loop/lid; other site 1274814005970 ABC transporter signature motif; other site 1274814005971 Walker B; other site 1274814005972 D-loop; other site 1274814005973 H-loop/switch region; other site 1274814005974 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1274814005975 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 1274814005976 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814005977 Walker A/P-loop; other site 1274814005978 ATP binding site [chemical binding]; other site 1274814005979 Q-loop/lid; other site 1274814005980 ABC transporter signature motif; other site 1274814005981 Walker B; other site 1274814005982 D-loop; other site 1274814005983 H-loop/switch region; other site 1274814005984 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1274814005985 dsDNA-mimic protein; Reviewed; Region: PRK05094 1274814005986 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 1274814005987 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 1274814005988 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 1274814005989 putative active site [active] 1274814005990 catalytic site [active] 1274814005991 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 1274814005992 putative active site [active] 1274814005993 catalytic site [active] 1274814005994 voltage-gated potassium channel; Provisional; Region: PRK10537 1274814005995 Ion channel; Region: Ion_trans_2; pfam07885 1274814005996 TrkA-N domain; Region: TrkA_N; pfam02254 1274814005997 YciI-like protein; Reviewed; Region: PRK11370 1274814005998 transport protein TonB; Provisional; Region: PRK10819 1274814005999 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 1274814006000 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 1274814006001 intracellular septation protein A; Reviewed; Region: PRK00259 1274814006002 hypothetical protein; Provisional; Region: PRK02868 1274814006003 outer membrane protein W; Provisional; Region: PRK10959 1274814006004 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 1274814006005 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 1274814006006 dimerization interface [polypeptide binding]; other site 1274814006007 metal binding site [ion binding]; metal-binding site 1274814006008 General stress protein [General function prediction only]; Region: GsiB; COG3729 1274814006009 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 1274814006010 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 1274814006011 substrate binding site [chemical binding]; other site 1274814006012 active site 1274814006013 catalytic residues [active] 1274814006014 heterodimer interface [polypeptide binding]; other site 1274814006015 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 1274814006016 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 1274814006017 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814006018 catalytic residue [active] 1274814006019 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 1274814006020 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 1274814006021 active site 1274814006022 ribulose/triose binding site [chemical binding]; other site 1274814006023 phosphate binding site [ion binding]; other site 1274814006024 substrate (anthranilate) binding pocket [chemical binding]; other site 1274814006025 product (indole) binding pocket [chemical binding]; other site 1274814006026 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 1274814006027 active site 1274814006028 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 1274814006029 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1274814006030 glutamine binding [chemical binding]; other site 1274814006031 catalytic triad [active] 1274814006032 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 1274814006033 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 1274814006034 anthranilate synthase component I; Provisional; Region: PRK13564 1274814006035 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1274814006036 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 1274814006037 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 1274814006038 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1274814006039 active site 1274814006040 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 1274814006041 hypothetical protein; Provisional; Region: PRK11630 1274814006042 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 1274814006043 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1274814006044 RNA binding surface [nucleotide binding]; other site 1274814006045 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 1274814006046 probable active site [active] 1274814006047 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 1274814006048 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 1274814006049 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 1274814006050 homodimer interface [polypeptide binding]; other site 1274814006051 Walker A motif; other site 1274814006052 ATP binding site [chemical binding]; other site 1274814006053 hydroxycobalamin binding site [chemical binding]; other site 1274814006054 Walker B motif; other site 1274814006055 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 1274814006056 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 1274814006057 NADP binding site [chemical binding]; other site 1274814006058 homodimer interface [polypeptide binding]; other site 1274814006059 active site 1274814006060 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 1274814006061 putative inner membrane peptidase; Provisional; Region: PRK11778 1274814006062 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 1274814006063 tandem repeat interface [polypeptide binding]; other site 1274814006064 oligomer interface [polypeptide binding]; other site 1274814006065 active site residues [active] 1274814006066 hypothetical protein; Provisional; Region: PRK11037 1274814006067 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 1274814006068 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 1274814006069 active site 1274814006070 interdomain interaction site; other site 1274814006071 putative metal-binding site [ion binding]; other site 1274814006072 nucleotide binding site [chemical binding]; other site 1274814006073 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1274814006074 domain I; other site 1274814006075 DNA binding groove [nucleotide binding] 1274814006076 phosphate binding site [ion binding]; other site 1274814006077 domain II; other site 1274814006078 domain III; other site 1274814006079 nucleotide binding site [chemical binding]; other site 1274814006080 catalytic site [active] 1274814006081 domain IV; other site 1274814006082 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1274814006083 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1274814006084 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1274814006085 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 1274814006086 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 1274814006087 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814006088 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 1274814006089 substrate binding site [chemical binding]; other site 1274814006090 putative dimerization interface [polypeptide binding]; other site 1274814006091 aconitate hydratase; Validated; Region: PRK09277 1274814006092 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 1274814006093 substrate binding site [chemical binding]; other site 1274814006094 ligand binding site [chemical binding]; other site 1274814006095 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 1274814006096 substrate binding site [chemical binding]; other site 1274814006097 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 1274814006098 dimerization interface [polypeptide binding]; other site 1274814006099 active site 1274814006100 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1274814006101 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1274814006102 active site 1274814006103 Predicted membrane protein [Function unknown]; Region: COG3771 1274814006104 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 1274814006105 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 1274814006106 TPR motif; other site 1274814006107 binding surface 1274814006108 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1274814006109 binding surface 1274814006110 TPR motif; other site 1274814006111 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 1274814006112 active site 1274814006113 dimer interface [polypeptide binding]; other site 1274814006114 translation initiation factor Sui1; Validated; Region: PRK06824 1274814006115 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 1274814006116 putative rRNA binding site [nucleotide binding]; other site 1274814006117 lipoprotein; Provisional; Region: PRK10540 1274814006118 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1274814006119 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1274814006120 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1274814006121 hypothetical protein; Provisional; Region: PRK13658 1274814006122 RNase II stability modulator; Provisional; Region: PRK10060 1274814006123 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1274814006124 putative active site [active] 1274814006125 heme pocket [chemical binding]; other site 1274814006126 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814006127 metal binding site [ion binding]; metal-binding site 1274814006128 active site 1274814006129 I-site; other site 1274814006130 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814006131 exoribonuclease II; Provisional; Region: PRK05054 1274814006132 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 1274814006133 RNB domain; Region: RNB; pfam00773 1274814006134 S1 RNA binding domain; Region: S1; pfam00575 1274814006135 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 1274814006136 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1274814006137 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 1274814006138 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 1274814006139 NAD binding site [chemical binding]; other site 1274814006140 homotetramer interface [polypeptide binding]; other site 1274814006141 homodimer interface [polypeptide binding]; other site 1274814006142 substrate binding site [chemical binding]; other site 1274814006143 active site 1274814006144 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 1274814006145 putative active site [active] 1274814006146 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 1274814006147 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814006148 Walker A/P-loop; other site 1274814006149 ATP binding site [chemical binding]; other site 1274814006150 Q-loop/lid; other site 1274814006151 ABC transporter signature motif; other site 1274814006152 Walker B; other site 1274814006153 D-loop; other site 1274814006154 H-loop/switch region; other site 1274814006155 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 1274814006156 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814006157 Walker A/P-loop; other site 1274814006158 ATP binding site [chemical binding]; other site 1274814006159 Q-loop/lid; other site 1274814006160 ABC transporter signature motif; other site 1274814006161 Walker B; other site 1274814006162 D-loop; other site 1274814006163 H-loop/switch region; other site 1274814006164 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1274814006165 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 1274814006166 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1274814006167 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814006168 dimer interface [polypeptide binding]; other site 1274814006169 conserved gate region; other site 1274814006170 putative PBP binding loops; other site 1274814006171 ABC-ATPase subunit interface; other site 1274814006172 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 1274814006173 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814006174 dimer interface [polypeptide binding]; other site 1274814006175 conserved gate region; other site 1274814006176 putative PBP binding loops; other site 1274814006177 ABC-ATPase subunit interface; other site 1274814006178 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1274814006179 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1274814006180 peptide binding site [polypeptide binding]; other site 1274814006181 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 1274814006182 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1274814006183 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1274814006184 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 1274814006185 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 1274814006186 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 1274814006187 catalytic triad [active] 1274814006188 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 1274814006189 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814006190 non-specific DNA binding site [nucleotide binding]; other site 1274814006191 salt bridge; other site 1274814006192 sequence-specific DNA binding site [nucleotide binding]; other site 1274814006193 Cupin domain; Region: Cupin_2; pfam07883 1274814006194 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 1274814006195 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 1274814006196 NAD(P) binding site [chemical binding]; other site 1274814006197 catalytic residues [active] 1274814006198 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 1274814006199 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 1274814006200 4-aminobutyrate transaminase; Provisional; Region: PRK09792 1274814006201 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1274814006202 inhibitor-cofactor binding pocket; inhibition site 1274814006203 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814006204 catalytic residue [active] 1274814006205 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 1274814006206 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814006207 Walker A motif; other site 1274814006208 ATP binding site [chemical binding]; other site 1274814006209 Walker B motif; other site 1274814006210 arginine finger; other site 1274814006211 phage shock protein PspA; Provisional; Region: PRK10698 1274814006212 phage shock protein B; Provisional; Region: pspB; PRK09458 1274814006213 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 1274814006214 phage shock protein C; Region: phageshock_pspC; TIGR02978 1274814006215 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 1274814006216 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1274814006217 active site residue [active] 1274814006218 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 1274814006219 sucrose phosphorylase; Provisional; Region: PRK13840 1274814006220 active site 1274814006221 homodimer interface [polypeptide binding]; other site 1274814006222 catalytic site [active] 1274814006223 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1274814006224 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 1274814006225 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 1274814006226 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814006227 dimer interface [polypeptide binding]; other site 1274814006228 conserved gate region; other site 1274814006229 putative PBP binding loops; other site 1274814006230 ABC-ATPase subunit interface; other site 1274814006231 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1274814006232 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814006233 dimer interface [polypeptide binding]; other site 1274814006234 conserved gate region; other site 1274814006235 putative PBP binding loops; other site 1274814006236 ABC-ATPase subunit interface; other site 1274814006237 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1274814006238 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 1274814006239 putative NAD(P) binding site [chemical binding]; other site 1274814006240 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 1274814006241 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1274814006242 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1274814006243 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1274814006244 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 1274814006245 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 1274814006246 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 1274814006247 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 1274814006248 beta-phosphoglucomutase; Region: bPGM; TIGR01990 1274814006249 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814006250 motif II; other site 1274814006251 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 1274814006252 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1274814006253 Walker A/P-loop; other site 1274814006254 ATP binding site [chemical binding]; other site 1274814006255 Q-loop/lid; other site 1274814006256 ABC transporter signature motif; other site 1274814006257 Walker B; other site 1274814006258 D-loop; other site 1274814006259 H-loop/switch region; other site 1274814006260 TOBE domain; Region: TOBE_2; pfam08402 1274814006261 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 1274814006262 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1274814006263 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814006264 DNA binding site [nucleotide binding] 1274814006265 domain linker motif; other site 1274814006266 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 1274814006267 putative dimerization interface [polypeptide binding]; other site 1274814006268 putative ligand binding site [chemical binding]; other site 1274814006269 Predicted ATPase [General function prediction only]; Region: COG3106 1274814006270 hypothetical protein; Provisional; Region: PRK05415 1274814006271 TIGR01620 family protein; Region: hyp_HI0043 1274814006272 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 1274814006273 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 1274814006274 putative aromatic amino acid binding site; other site 1274814006275 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814006276 Walker A motif; other site 1274814006277 ATP binding site [chemical binding]; other site 1274814006278 Walker B motif; other site 1274814006279 arginine finger; other site 1274814006280 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 1274814006281 dimer interface [polypeptide binding]; other site 1274814006282 catalytic triad [active] 1274814006283 peroxidatic and resolving cysteines [active] 1274814006284 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 1274814006285 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 1274814006286 active site 1274814006287 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 1274814006288 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 1274814006289 putative active site [active] 1274814006290 Zn binding site [ion binding]; other site 1274814006291 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1274814006292 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1274814006293 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1274814006294 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1274814006295 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814006296 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 1274814006297 putative effector binding pocket; other site 1274814006298 putative dimerization interface [polypeptide binding]; other site 1274814006299 Uncharacterized BCR, COG1636; Region: DUF208; cl17782 1274814006300 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 1274814006301 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1274814006302 peptide binding site [polypeptide binding]; other site 1274814006303 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 1274814006304 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1274814006305 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 1274814006306 universal stress protein UspE; Provisional; Region: PRK11175 1274814006307 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1274814006308 Ligand Binding Site [chemical binding]; other site 1274814006309 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1274814006310 Ligand Binding Site [chemical binding]; other site 1274814006311 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 1274814006312 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1274814006313 ligand binding site [chemical binding]; other site 1274814006314 flexible hinge region; other site 1274814006315 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1274814006316 putative switch regulator; other site 1274814006317 non-specific DNA interactions [nucleotide binding]; other site 1274814006318 DNA binding site [nucleotide binding] 1274814006319 sequence specific DNA binding site [nucleotide binding]; other site 1274814006320 putative cAMP binding site [chemical binding]; other site 1274814006321 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 1274814006322 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1274814006323 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1274814006324 DNA binding site [nucleotide binding] 1274814006325 active site 1274814006326 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 1274814006327 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 1274814006328 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 1274814006329 amidohydrolase; Region: amidohydrolases; TIGR01891 1274814006330 putative metal binding site [ion binding]; other site 1274814006331 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 1274814006332 amidohydrolase; Region: amidohydrolases; TIGR01891 1274814006333 putative metal binding site [ion binding]; other site 1274814006334 dimer interface [polypeptide binding]; other site 1274814006335 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 1274814006336 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814006337 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1274814006338 putative substrate binding pocket [chemical binding]; other site 1274814006339 putative dimerization interface [polypeptide binding]; other site 1274814006340 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 1274814006341 Smr domain; Region: Smr; pfam01713 1274814006342 PAS domain S-box; Region: sensory_box; TIGR00229 1274814006343 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1274814006344 putative active site [active] 1274814006345 heme pocket [chemical binding]; other site 1274814006346 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1274814006347 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814006348 metal binding site [ion binding]; metal-binding site 1274814006349 active site 1274814006350 I-site; other site 1274814006351 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1274814006352 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 1274814006353 Cl binding site [ion binding]; other site 1274814006354 oligomer interface [polypeptide binding]; other site 1274814006355 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 1274814006356 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1274814006357 ATP binding site [chemical binding]; other site 1274814006358 Mg++ binding site [ion binding]; other site 1274814006359 motif III; other site 1274814006360 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1274814006361 nucleotide binding region [chemical binding]; other site 1274814006362 ATP-binding site [chemical binding]; other site 1274814006363 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 1274814006364 putative RNA binding site [nucleotide binding]; other site 1274814006365 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 1274814006366 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 1274814006367 Ligand Binding Site [chemical binding]; other site 1274814006368 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1274814006369 Ligand Binding Site [chemical binding]; other site 1274814006370 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1274814006371 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1274814006372 trimer interface [polypeptide binding]; other site 1274814006373 eyelet of channel; other site 1274814006374 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 1274814006375 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 1274814006376 dimer interface [polypeptide binding]; other site 1274814006377 PYR/PP interface [polypeptide binding]; other site 1274814006378 TPP binding site [chemical binding]; other site 1274814006379 substrate binding site [chemical binding]; other site 1274814006380 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 1274814006381 Domain of unknown function; Region: EKR; smart00890 1274814006382 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1274814006383 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1274814006384 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 1274814006385 TPP-binding site [chemical binding]; other site 1274814006386 dimer interface [polypeptide binding]; other site 1274814006387 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1274814006388 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1274814006389 heat-inducible protein; Provisional; Region: PRK10449 1274814006390 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 1274814006391 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 1274814006392 putative ligand binding site [chemical binding]; other site 1274814006393 putative NAD binding site [chemical binding]; other site 1274814006394 catalytic site [active] 1274814006395 hypothetical protein; Provisional; Region: PRK10695 1274814006396 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 1274814006397 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 1274814006398 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 1274814006399 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814006400 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 1274814006401 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1274814006402 NAD(P) binding site [chemical binding]; other site 1274814006403 catalytic residues [active] 1274814006404 tyramine oxidase; Provisional; Region: tynA; PRK14696 1274814006405 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 1274814006406 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 1274814006407 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 1274814006408 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 1274814006409 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 1274814006410 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 1274814006411 substrate binding site [chemical binding]; other site 1274814006412 dimer interface [polypeptide binding]; other site 1274814006413 NADP binding site [chemical binding]; other site 1274814006414 catalytic residues [active] 1274814006415 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 1274814006416 substrate binding site [chemical binding]; other site 1274814006417 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 1274814006418 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 1274814006419 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 1274814006420 phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158 1274814006421 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 1274814006422 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 1274814006423 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 1274814006424 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 1274814006425 FAD binding pocket [chemical binding]; other site 1274814006426 FAD binding motif [chemical binding]; other site 1274814006427 phosphate binding motif [ion binding]; other site 1274814006428 beta-alpha-beta structure motif; other site 1274814006429 NAD(p) ribose binding residues [chemical binding]; other site 1274814006430 NAD binding pocket [chemical binding]; other site 1274814006431 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 1274814006432 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1274814006433 catalytic loop [active] 1274814006434 iron binding site [ion binding]; other site 1274814006435 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 1274814006436 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1274814006437 substrate binding site [chemical binding]; other site 1274814006438 oxyanion hole (OAH) forming residues; other site 1274814006439 trimer interface [polypeptide binding]; other site 1274814006440 enoyl-CoA hydratase; Provisional; Region: PRK08140 1274814006441 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1274814006442 substrate binding site [chemical binding]; other site 1274814006443 oxyanion hole (OAH) forming residues; other site 1274814006444 trimer interface [polypeptide binding]; other site 1274814006445 3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279 1274814006446 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1274814006447 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1274814006448 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1274814006449 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1274814006450 CoenzymeA binding site [chemical binding]; other site 1274814006451 subunit interaction site [polypeptide binding]; other site 1274814006452 PHB binding site; other site 1274814006453 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 1274814006454 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1274814006455 dimer interface [polypeptide binding]; other site 1274814006456 active site 1274814006457 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 1274814006458 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 1274814006459 active site 1274814006460 AMP binding site [chemical binding]; other site 1274814006461 homodimer interface [polypeptide binding]; other site 1274814006462 acyl-activating enzyme (AAE) consensus motif; other site 1274814006463 CoA binding site [chemical binding]; other site 1274814006464 PaaX-like protein; Region: PaaX; pfam07848 1274814006465 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 1274814006466 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 1274814006467 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 1274814006468 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 1274814006469 putative trimer interface [polypeptide binding]; other site 1274814006470 putative metal binding site [ion binding]; other site 1274814006471 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1274814006472 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1274814006473 active site 1274814006474 catalytic tetrad [active] 1274814006475 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 1274814006476 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 1274814006477 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1274814006478 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 1274814006479 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 1274814006480 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 1274814006481 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1274814006482 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814006483 S-adenosylmethionine binding site [chemical binding]; other site 1274814006484 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 1274814006485 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1274814006486 active site 1274814006487 Dual specificity phosphatase, catalytic domain; Region: DSPc; smart00195 1274814006488 active site 1274814006489 catalytic residues [active] 1274814006490 azoreductase; Reviewed; Region: PRK00170 1274814006491 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1274814006492 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 1274814006493 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1274814006494 ATP binding site [chemical binding]; other site 1274814006495 putative Mg++ binding site [ion binding]; other site 1274814006496 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1274814006497 nucleotide binding region [chemical binding]; other site 1274814006498 ATP-binding site [chemical binding]; other site 1274814006499 Helicase associated domain (HA2); Region: HA2; pfam04408 1274814006500 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 1274814006501 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 1274814006502 Uncharacterized conserved protein [Function unknown]; Region: COG1434 1274814006503 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1274814006504 putative active site [active] 1274814006505 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 1274814006506 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1274814006507 NAD binding site [chemical binding]; other site 1274814006508 catalytic residues [active] 1274814006509 substrate binding site [chemical binding]; other site 1274814006510 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 1274814006511 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1274814006512 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1274814006513 cytochrome b561; Provisional; Region: PRK11513 1274814006514 hypothetical protein; Provisional; Region: PRK10040 1274814006515 small toxic polypeptide; Provisional; Region: PRK09738 1274814006516 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1274814006517 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1274814006518 dimer interface [polypeptide binding]; other site 1274814006519 ligand binding site [chemical binding]; other site 1274814006520 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1274814006521 dimerization interface [polypeptide binding]; other site 1274814006522 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1274814006523 dimer interface [polypeptide binding]; other site 1274814006524 putative CheW interface [polypeptide binding]; other site 1274814006525 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 1274814006526 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814006527 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1274814006528 dimerization interface [polypeptide binding]; other site 1274814006529 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1274814006530 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 1274814006531 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 1274814006532 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 1274814006533 hypothetical protein; Provisional; Region: PRK11415 1274814006534 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 1274814006535 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814006536 Coenzyme A binding pocket [chemical binding]; other site 1274814006537 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1274814006538 putative trimer interface [polypeptide binding]; other site 1274814006539 putative CoA binding site [chemical binding]; other site 1274814006540 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 1274814006541 putative trimer interface [polypeptide binding]; other site 1274814006542 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 1274814006543 putative CoA binding site [chemical binding]; other site 1274814006544 putative trimer interface [polypeptide binding]; other site 1274814006545 putative CoA binding site [chemical binding]; other site 1274814006546 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 1274814006547 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 1274814006548 gating phenylalanine in ion channel; other site 1274814006549 tellurite resistance protein TehB; Provisional; Region: PRK11207 1274814006550 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814006551 S-adenosylmethionine binding site [chemical binding]; other site 1274814006552 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 1274814006553 Transposase IS200 like; Region: Y1_Tnp; cl00848 1274814006554 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1274814006555 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 1274814006556 Probable transposase; Region: OrfB_IS605; pfam01385 1274814006557 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1274814006558 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 1274814006559 benzoate transporter; Region: benE; TIGR00843 1274814006560 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1274814006561 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814006562 non-specific DNA binding site [nucleotide binding]; other site 1274814006563 salt bridge; other site 1274814006564 sequence-specific DNA binding site [nucleotide binding]; other site 1274814006565 Cupin domain; Region: Cupin_2; pfam07883 1274814006566 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1274814006567 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1274814006568 Peptidase family U32; Region: Peptidase_U32; pfam01136 1274814006569 Collagenase; Region: DUF3656; pfam12392 1274814006570 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 1274814006571 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 1274814006572 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814006573 sequence-specific DNA binding site [nucleotide binding]; other site 1274814006574 salt bridge; other site 1274814006575 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1274814006576 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814006577 DNA-binding site [nucleotide binding]; DNA binding site 1274814006578 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1274814006579 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814006580 homodimer interface [polypeptide binding]; other site 1274814006581 catalytic residue [active] 1274814006582 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1274814006583 Spermidine/putrescine-binding periplasmic protein [Amino acid transport and metabolism]; Region: PotD; COG0687 1274814006584 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 1274814006585 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 1274814006586 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814006587 Walker A/P-loop; other site 1274814006588 ATP binding site [chemical binding]; other site 1274814006589 Q-loop/lid; other site 1274814006590 ABC transporter signature motif; other site 1274814006591 Walker B; other site 1274814006592 D-loop; other site 1274814006593 H-loop/switch region; other site 1274814006594 TOBE domain; Region: TOBE_2; pfam08402 1274814006595 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814006596 dimer interface [polypeptide binding]; other site 1274814006597 conserved gate region; other site 1274814006598 putative PBP binding loops; other site 1274814006599 ABC-ATPase subunit interface; other site 1274814006600 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 1274814006601 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814006602 ABC-ATPase subunit interface; other site 1274814006603 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 1274814006604 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 1274814006605 tetrameric interface [polypeptide binding]; other site 1274814006606 NAD binding site [chemical binding]; other site 1274814006607 catalytic residues [active] 1274814006608 substrate binding site [chemical binding]; other site 1274814006609 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1274814006610 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 1274814006611 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 1274814006612 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 1274814006613 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1274814006614 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 1274814006615 Prostaglandin dehydrogenases; Region: PGDH; cd05288 1274814006616 NAD(P) binding site [chemical binding]; other site 1274814006617 substrate binding site [chemical binding]; other site 1274814006618 dimer interface [polypeptide binding]; other site 1274814006619 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 1274814006620 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814006621 DNA-binding site [nucleotide binding]; DNA binding site 1274814006622 FCD domain; Region: FCD; pfam07729 1274814006623 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1274814006624 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1274814006625 N-terminal plug; other site 1274814006626 ligand-binding site [chemical binding]; other site 1274814006627 PQQ-like domain; Region: PQQ_2; pfam13360 1274814006628 L-asparagine permease; Provisional; Region: PRK15049 1274814006629 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1274814006630 C-terminal domain interface [polypeptide binding]; other site 1274814006631 GSH binding site (G-site) [chemical binding]; other site 1274814006632 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 1274814006633 dimer interface [polypeptide binding]; other site 1274814006634 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1274814006635 dimer interface [polypeptide binding]; other site 1274814006636 N-terminal domain interface [polypeptide binding]; other site 1274814006637 substrate binding pocket (H-site) [chemical binding]; other site 1274814006638 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 1274814006639 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 1274814006640 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 1274814006641 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 1274814006642 PAAR motif; Region: PAAR_motif; cl15808 1274814006643 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1274814006644 RHS Repeat; Region: RHS_repeat; pfam05593 1274814006645 RHS Repeat; Region: RHS_repeat; pfam05593 1274814006646 RHS Repeat; Region: RHS_repeat; pfam05593 1274814006647 RHS Repeat; Region: RHS_repeat; pfam05593 1274814006648 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1274814006649 RHS Repeat; Region: RHS_repeat; pfam05593 1274814006650 RHS Repeat; Region: RHS_repeat; pfam05593 1274814006651 RHS protein; Region: RHS; pfam03527 1274814006652 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1274814006653 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 1274814006654 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 1274814006655 Transposase [DNA replication, recombination, and repair]; Region: COG5433 1274814006656 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 1274814006657 active site 1 [active] 1274814006658 dimer interface [polypeptide binding]; other site 1274814006659 hexamer interface [polypeptide binding]; other site 1274814006660 active site 2 [active] 1274814006661 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 1274814006662 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 1274814006663 hypothetical protein; Provisional; Region: PRK10281 1274814006664 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 1274814006665 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 1274814006666 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 1274814006667 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 1274814006668 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 1274814006669 [4Fe-4S] binding site [ion binding]; other site 1274814006670 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1274814006671 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1274814006672 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1274814006673 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 1274814006674 molybdopterin cofactor binding site; other site 1274814006675 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 1274814006676 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 1274814006677 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1274814006678 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1274814006679 aromatic amino acid exporter; Provisional; Region: PRK11689 1274814006680 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1274814006681 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1274814006682 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1274814006683 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 1274814006684 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 1274814006685 molybdopterin cofactor binding site; other site 1274814006686 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 1274814006687 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 1274814006688 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 1274814006689 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 1274814006690 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 1274814006691 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814006692 non-specific DNA binding site [nucleotide binding]; other site 1274814006693 salt bridge; other site 1274814006694 sequence-specific DNA binding site [nucleotide binding]; other site 1274814006695 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 1274814006696 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 1274814006697 NAD binding site [chemical binding]; other site 1274814006698 substrate binding site [chemical binding]; other site 1274814006699 catalytic Zn binding site [ion binding]; other site 1274814006700 tetramer interface [polypeptide binding]; other site 1274814006701 structural Zn binding site [ion binding]; other site 1274814006702 malate dehydrogenase; Provisional; Region: PRK13529 1274814006703 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1274814006704 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 1274814006705 NAD(P) binding site [chemical binding]; other site 1274814006706 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 1274814006707 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 1274814006708 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 1274814006709 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 1274814006710 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814006711 Walker A/P-loop; other site 1274814006712 ATP binding site [chemical binding]; other site 1274814006713 Q-loop/lid; other site 1274814006714 ABC transporter signature motif; other site 1274814006715 Walker B; other site 1274814006716 D-loop; other site 1274814006717 H-loop/switch region; other site 1274814006718 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1274814006719 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 1274814006720 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814006721 Walker A/P-loop; other site 1274814006722 ATP binding site [chemical binding]; other site 1274814006723 Q-loop/lid; other site 1274814006724 ABC transporter signature motif; other site 1274814006725 Walker B; other site 1274814006726 D-loop; other site 1274814006727 H-loop/switch region; other site 1274814006728 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 1274814006729 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 1274814006730 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1274814006731 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814006732 dimer interface [polypeptide binding]; other site 1274814006733 conserved gate region; other site 1274814006734 putative PBP binding loops; other site 1274814006735 ABC-ATPase subunit interface; other site 1274814006736 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1274814006737 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814006738 dimer interface [polypeptide binding]; other site 1274814006739 conserved gate region; other site 1274814006740 putative PBP binding loops; other site 1274814006741 ABC-ATPase subunit interface; other site 1274814006742 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1274814006743 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 1274814006744 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 1274814006745 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 1274814006746 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1274814006747 putative active site [active] 1274814006748 heme pocket [chemical binding]; other site 1274814006749 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1274814006750 putative active site [active] 1274814006751 heme pocket [chemical binding]; other site 1274814006752 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814006753 metal binding site [ion binding]; metal-binding site 1274814006754 active site 1274814006755 I-site; other site 1274814006756 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814006757 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 1274814006758 heme-binding site [chemical binding]; other site 1274814006759 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1274814006760 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814006761 metal binding site [ion binding]; metal-binding site 1274814006762 active site 1274814006763 I-site; other site 1274814006764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 1274814006765 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 1274814006766 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 1274814006767 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1274814006768 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814006769 catalytic residue [active] 1274814006770 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1274814006771 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1274814006772 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1274814006773 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1274814006774 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1274814006775 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 1274814006776 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 1274814006777 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 1274814006778 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 1274814006779 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 1274814006780 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1274814006781 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1274814006782 IS2 transposase TnpB; Reviewed; Region: PRK09409 1274814006783 HTH-like domain; Region: HTH_21; pfam13276 1274814006784 Integrase core domain; Region: rve; pfam00665 1274814006785 Integrase core domain; Region: rve_3; pfam13683 1274814006786 IS2 repressor TnpA; Reviewed; Region: PRK09413 1274814006787 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814006788 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1274814006789 Sulfatase; Region: Sulfatase; pfam00884 1274814006790 transcriptional regulator YdeO; Provisional; Region: PRK09940 1274814006791 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814006792 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 1274814006793 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 1274814006794 putative molybdopterin cofactor binding site [chemical binding]; other site 1274814006795 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 1274814006796 putative molybdopterin cofactor binding site; other site 1274814006797 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 1274814006798 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 1274814006799 mannosyl binding site [chemical binding]; other site 1274814006800 Fimbrial protein; Region: Fimbrial; pfam00419 1274814006801 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1274814006802 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1274814006803 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1274814006804 PapC N-terminal domain; Region: PapC_N; pfam13954 1274814006805 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1274814006806 PapC C-terminal domain; Region: PapC_C; pfam13953 1274814006807 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 1274814006808 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1274814006809 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1274814006810 Fimbrial protein; Region: Fimbrial; cl01416 1274814006811 Helix-turn-helix domain; Region: HTH_18; pfam12833 1274814006812 HipA N-terminal domain; Region: Couple_hipA; pfam13657 1274814006813 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 1274814006814 HipA-like N-terminal domain; Region: HipA_N; pfam07805 1274814006815 HipA-like C-terminal domain; Region: HipA_C; pfam07804 1274814006816 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 1274814006817 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814006818 non-specific DNA binding site [nucleotide binding]; other site 1274814006819 salt bridge; other site 1274814006820 sequence-specific DNA binding site [nucleotide binding]; other site 1274814006821 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 1274814006822 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1274814006823 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1274814006824 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1274814006825 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 1274814006826 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 1274814006827 putative N- and C-terminal domain interface [polypeptide binding]; other site 1274814006828 putative active site [active] 1274814006829 putative MgATP binding site [chemical binding]; other site 1274814006830 catalytic site [active] 1274814006831 metal binding site [ion binding]; metal-binding site 1274814006832 putative carbohydrate binding site [chemical binding]; other site 1274814006833 transcriptional regulator LsrR; Provisional; Region: PRK15418 1274814006834 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1274814006835 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 1274814006836 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 1274814006837 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1274814006838 Walker A/P-loop; other site 1274814006839 ATP binding site [chemical binding]; other site 1274814006840 Q-loop/lid; other site 1274814006841 ABC transporter signature motif; other site 1274814006842 Walker B; other site 1274814006843 D-loop; other site 1274814006844 H-loop/switch region; other site 1274814006845 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1274814006846 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1274814006847 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1274814006848 TM-ABC transporter signature motif; other site 1274814006849 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1274814006850 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1274814006851 TM-ABC transporter signature motif; other site 1274814006852 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 1274814006853 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 1274814006854 ligand binding site [chemical binding]; other site 1274814006855 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 1274814006856 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1274814006857 putative active site; other site 1274814006858 catalytic residue [active] 1274814006859 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 1274814006860 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 1274814006861 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814006862 S-adenosylmethionine binding site [chemical binding]; other site 1274814006863 Predicted membrane protein [Function unknown]; Region: COG3781 1274814006864 altronate oxidoreductase; Provisional; Region: PRK03643 1274814006865 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1274814006866 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1274814006867 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1274814006868 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814006869 metal binding site [ion binding]; metal-binding site 1274814006870 active site 1274814006871 I-site; other site 1274814006872 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 1274814006873 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 1274814006874 glutaminase; Provisional; Region: PRK00971 1274814006875 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 1274814006876 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 1274814006877 NAD(P) binding site [chemical binding]; other site 1274814006878 catalytic residues [active] 1274814006879 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1274814006880 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814006881 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 1274814006882 putative dimerization interface [polypeptide binding]; other site 1274814006883 putative arabinose transporter; Provisional; Region: PRK03545 1274814006884 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814006885 putative substrate translocation pore; other site 1274814006886 inner membrane protein; Provisional; Region: PRK10995 1274814006887 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 1274814006888 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1274814006889 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 1274814006890 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814006891 hypothetical protein; Provisional; Region: PRK10106 1274814006892 6-phospho-beta-glucosidase; Reviewed; Region: celA; PRK09589 1274814006893 beta-galactosidase; Region: BGL; TIGR03356 1274814006894 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1274814006895 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1274814006896 trimer interface; other site 1274814006897 sugar binding site [chemical binding]; other site 1274814006898 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1274814006899 active site 1274814006900 methionine cluster; other site 1274814006901 phosphorylation site [posttranslational modification] 1274814006902 metal binding site [ion binding]; metal-binding site 1274814006903 Phosphotransferase system cellobiose-specific component IIC [Carbohydrate transport and metabolism]; Region: CelB; COG1455 1274814006904 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 1274814006905 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1274814006906 active site 1274814006907 P-loop; other site 1274814006908 phosphorylation site [posttranslational modification] 1274814006909 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1274814006910 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814006911 DNA-binding site [nucleotide binding]; DNA binding site 1274814006912 UTRA domain; Region: UTRA; pfam07702 1274814006913 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 1274814006914 EamA-like transporter family; Region: EamA; pfam00892 1274814006915 EamA-like transporter family; Region: EamA; pfam00892 1274814006916 putative transporter; Provisional; Region: PRK10054 1274814006917 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814006918 putative substrate translocation pore; other site 1274814006919 diguanylate cyclase; Provisional; Region: PRK09894 1274814006920 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 1274814006921 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814006922 metal binding site [ion binding]; metal-binding site 1274814006923 active site 1274814006924 I-site; other site 1274814006925 hypothetical protein; Provisional; Region: PRK10053 1274814006926 hypothetical protein; Validated; Region: PRK03657 1274814006927 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 1274814006928 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1274814006929 active site 1274814006930 Zn binding site [ion binding]; other site 1274814006931 malonic semialdehyde reductase; Provisional; Region: PRK10538 1274814006932 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 1274814006933 putative NAD(P) binding site [chemical binding]; other site 1274814006934 homodimer interface [polypeptide binding]; other site 1274814006935 homotetramer interface [polypeptide binding]; other site 1274814006936 active site 1274814006937 Transcriptional regulators [Transcription]; Region: GntR; COG1802 1274814006938 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814006939 DNA-binding site [nucleotide binding]; DNA binding site 1274814006940 FCD domain; Region: FCD; pfam07729 1274814006941 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 1274814006942 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1274814006943 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1274814006944 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1274814006945 metabolite-proton symporter; Region: 2A0106; TIGR00883 1274814006946 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814006947 putative substrate translocation pore; other site 1274814006948 multiple promoter invertase; Provisional; Region: mpi; PRK13413 1274814006949 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 1274814006950 catalytic residues [active] 1274814006951 catalytic nucleophile [active] 1274814006952 Presynaptic Site I dimer interface [polypeptide binding]; other site 1274814006953 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 1274814006954 Synaptic Flat tetramer interface [polypeptide binding]; other site 1274814006955 Synaptic Site I dimer interface [polypeptide binding]; other site 1274814006956 DNA binding site [nucleotide binding] 1274814006957 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 1274814006958 DNA-binding interface [nucleotide binding]; DNA binding site 1274814006959 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1274814006960 Phage Tail Collar Domain; Region: Collar; pfam07484 1274814006961 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_1; cd07016 1274814006962 Clp protease; Region: CLP_protease; pfam00574 1274814006963 oligomer interface [polypeptide binding]; other site 1274814006964 active site residues [active] 1274814006965 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 1274814006966 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 1274814006967 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 1274814006968 Protein of unknown function (DUF1441); Region: DUF1441; pfam07278 1274814006969 Protein of unknown function (DUF1398); Region: DUF1398; cl11576 1274814006970 GnsA/GnsB family; Region: GnsAB; pfam08178 1274814006971 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1274814006972 DNA-binding site [nucleotide binding]; DNA binding site 1274814006973 RNA-binding motif; other site 1274814006974 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 1274814006975 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 1274814006976 catalytic residues [active] 1274814006977 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 1274814006978 Lysis protein S; Region: Lysis_S; pfam04971 1274814006979 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1274814006980 DNA-binding site [nucleotide binding]; DNA binding site 1274814006981 RNA-binding motif; other site 1274814006982 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1274814006983 DNA-binding site [nucleotide binding]; DNA binding site 1274814006984 RNA-binding motif; other site 1274814006985 Antitermination protein; Region: Antiterm; pfam03589 1274814006986 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1274814006987 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 1274814006988 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 1274814006989 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 1274814006990 active site 1274814006991 Hok/gef family; Region: HOK_GEF; pfam01848 1274814006992 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 1274814006993 IS2 transposase TnpB; Reviewed; Region: PRK09409 1274814006994 HTH-like domain; Region: HTH_21; pfam13276 1274814006995 Integrase core domain; Region: rve; pfam00665 1274814006996 Integrase core domain; Region: rve_3; pfam13683 1274814006997 IS2 repressor TnpA; Reviewed; Region: PRK09413 1274814006998 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814006999 primosomal protein DnaI; Provisional; Region: PRK02854 1274814007000 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 1274814007001 Uncharacterized protein conserved in bacteria, prophage-related [Function unknown]; Region: COG4197 1274814007002 transcriptional repressor DicA; Reviewed; Region: PRK09706 1274814007003 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 1274814007004 DicB protein; Region: DicB; pfam05358 1274814007005 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1274814007006 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 1274814007007 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1274814007008 active site 1274814007009 catalytic site [active] 1274814007010 substrate binding site [chemical binding]; other site 1274814007011 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 1274814007012 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 1274814007013 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 1274814007014 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 1274814007015 Int/Topo IB signature motif; other site 1274814007016 putative oxidoreductase; Provisional; Region: PRK10083 1274814007017 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 1274814007018 putative NAD(P) binding site [chemical binding]; other site 1274814007019 catalytic Zn binding site [ion binding]; other site 1274814007020 structural Zn binding site [ion binding]; other site 1274814007021 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 1274814007022 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 1274814007023 putative active site pocket [active] 1274814007024 putative metal binding site [ion binding]; other site 1274814007025 hypothetical protein; Provisional; Region: PRK02237 1274814007026 hypothetical protein; Provisional; Region: PRK13659 1274814007027 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 1274814007028 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814007029 Coenzyme A binding pocket [chemical binding]; other site 1274814007030 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 1274814007031 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 1274814007032 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1274814007033 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1274814007034 putative [Fe4-S4] binding site [ion binding]; other site 1274814007035 putative molybdopterin cofactor binding site [chemical binding]; other site 1274814007036 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1274814007037 putative molybdopterin cofactor binding site; other site 1274814007038 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 1274814007039 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 1274814007040 putative [Fe4-S4] binding site [ion binding]; other site 1274814007041 putative molybdopterin cofactor binding site [chemical binding]; other site 1274814007042 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 1274814007043 putative molybdopterin cofactor binding site; other site 1274814007044 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 1274814007045 4Fe-4S binding domain; Region: Fer4; cl02805 1274814007046 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 1274814007047 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 1274814007048 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1274814007049 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1274814007050 Cl- selectivity filter; other site 1274814007051 Cl- binding residues [ion binding]; other site 1274814007052 pore gating glutamate residue; other site 1274814007053 dimer interface [polypeptide binding]; other site 1274814007054 putative dithiobiotin synthetase; Provisional; Region: PRK12374 1274814007055 AAA domain; Region: AAA_26; pfam13500 1274814007056 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 1274814007057 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1274814007058 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1274814007059 nucleotide binding site [chemical binding]; other site 1274814007060 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1274814007061 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814007062 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 1274814007063 dimerization interface [polypeptide binding]; other site 1274814007064 substrate binding pocket [chemical binding]; other site 1274814007065 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1274814007066 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814007067 putative substrate translocation pore; other site 1274814007068 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 1274814007069 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 1274814007070 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 1274814007071 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 1274814007072 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1274814007073 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 1274814007074 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 1274814007075 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 1274814007076 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 1274814007077 ligand binding site [chemical binding]; other site 1274814007078 homodimer interface [polypeptide binding]; other site 1274814007079 NAD(P) binding site [chemical binding]; other site 1274814007080 trimer interface B [polypeptide binding]; other site 1274814007081 trimer interface A [polypeptide binding]; other site 1274814007082 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 1274814007083 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1274814007084 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1274814007085 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1274814007086 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 1274814007087 Spore germination protein; Region: Spore_permease; cl17796 1274814007088 dihydromonapterin reductase; Provisional; Region: PRK06483 1274814007089 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1274814007090 NAD(P) binding site [chemical binding]; other site 1274814007091 active site 1274814007092 GlpM protein; Region: GlpM; pfam06942 1274814007093 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 1274814007094 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814007095 active site 1274814007096 phosphorylation site [posttranslational modification] 1274814007097 intermolecular recognition site; other site 1274814007098 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814007099 DNA binding site [nucleotide binding] 1274814007100 sensor protein RstB; Provisional; Region: PRK10604 1274814007101 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1274814007102 dimerization interface [polypeptide binding]; other site 1274814007103 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814007104 dimer interface [polypeptide binding]; other site 1274814007105 phosphorylation site [posttranslational modification] 1274814007106 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814007107 ATP binding site [chemical binding]; other site 1274814007108 Mg2+ binding site [ion binding]; other site 1274814007109 G-X-G motif; other site 1274814007110 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 1274814007111 fumarate hydratase; Reviewed; Region: fumC; PRK00485 1274814007112 Class II fumarases; Region: Fumarase_classII; cd01362 1274814007113 active site 1274814007114 tetramer interface [polypeptide binding]; other site 1274814007115 fumarate hydratase; Provisional; Region: PRK15389 1274814007116 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 1274814007117 Fumarase C-terminus; Region: Fumerase_C; pfam05683 1274814007118 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 1274814007119 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 1274814007120 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 1274814007121 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 1274814007122 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 1274814007123 putative outer membrane porin protein; Provisional; Region: PRK11379 1274814007124 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1274814007125 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1274814007126 beta-D-glucuronidase; Provisional; Region: PRK10150 1274814007127 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1274814007128 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1274814007129 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1274814007130 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1274814007131 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1274814007132 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 1274814007133 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 1274814007134 NAD binding site [chemical binding]; other site 1274814007135 substrate binding site [chemical binding]; other site 1274814007136 homotetramer interface [polypeptide binding]; other site 1274814007137 homodimer interface [polypeptide binding]; other site 1274814007138 active site 1274814007139 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 1274814007140 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814007141 DNA binding site [nucleotide binding] 1274814007142 domain linker motif; other site 1274814007143 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 1274814007144 putative dimerization interface [polypeptide binding]; other site 1274814007145 putative ligand binding site [chemical binding]; other site 1274814007146 bifunctional PTS system maltose and glucose-specific transporter subunits IICB; Provisional; Region: PRK10110 1274814007147 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1274814007148 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1274814007149 active site turn [active] 1274814007150 phosphorylation site [posttranslational modification] 1274814007151 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 1274814007152 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1274814007153 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814007154 homodimer interface [polypeptide binding]; other site 1274814007155 catalytic residue [active] 1274814007156 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 1274814007157 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 1274814007158 active site 1274814007159 purine riboside binding site [chemical binding]; other site 1274814007160 putative oxidoreductase; Provisional; Region: PRK11579 1274814007161 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1274814007162 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1274814007163 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 1274814007164 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 1274814007165 electron transport complex protein RsxA; Provisional; Region: PRK05151 1274814007166 electron transport complex protein RnfB; Provisional; Region: PRK05113 1274814007167 Putative Fe-S cluster; Region: FeS; pfam04060 1274814007168 4Fe-4S binding domain; Region: Fer4; pfam00037 1274814007169 electron transport complex protein RnfC; Provisional; Region: PRK05035 1274814007170 SLBB domain; Region: SLBB; pfam10531 1274814007171 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1274814007172 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 1274814007173 electron transport complex protein RnfG; Validated; Region: PRK01908 1274814007174 electron transport complex RsxE subunit; Provisional; Region: PRK12405 1274814007175 endonuclease III; Provisional; Region: PRK10702 1274814007176 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1274814007177 minor groove reading motif; other site 1274814007178 helix-hairpin-helix signature motif; other site 1274814007179 substrate binding pocket [chemical binding]; other site 1274814007180 active site 1274814007181 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 1274814007182 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 1274814007183 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814007184 putative substrate translocation pore; other site 1274814007185 POT family; Region: PTR2; pfam00854 1274814007186 glutathionine S-transferase; Provisional; Region: PRK10542 1274814007187 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 1274814007188 C-terminal domain interface [polypeptide binding]; other site 1274814007189 GSH binding site (G-site) [chemical binding]; other site 1274814007190 dimer interface [polypeptide binding]; other site 1274814007191 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 1274814007192 N-terminal domain interface [polypeptide binding]; other site 1274814007193 dimer interface [polypeptide binding]; other site 1274814007194 substrate binding pocket (H-site) [chemical binding]; other site 1274814007195 pyridoxamine kinase; Validated; Region: PRK05756 1274814007196 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1274814007197 dimer interface [polypeptide binding]; other site 1274814007198 pyridoxal binding site [chemical binding]; other site 1274814007199 ATP binding site [chemical binding]; other site 1274814007200 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 1274814007201 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 1274814007202 active site 1274814007203 HIGH motif; other site 1274814007204 dimer interface [polypeptide binding]; other site 1274814007205 KMSKS motif; other site 1274814007206 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1274814007207 RNA binding surface [nucleotide binding]; other site 1274814007208 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 1274814007209 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 1274814007210 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 1274814007211 lysozyme inhibitor; Provisional; Region: PRK11372 1274814007212 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 1274814007213 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 1274814007214 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 1274814007215 transcriptional regulator SlyA; Provisional; Region: PRK03573 1274814007216 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 1274814007217 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 1274814007218 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1274814007219 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1274814007220 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814007221 Fusaric acid resistance protein family; Region: FUSC; pfam04632 1274814007222 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1274814007223 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 1274814007224 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 1274814007225 E-class dimer interface [polypeptide binding]; other site 1274814007226 P-class dimer interface [polypeptide binding]; other site 1274814007227 active site 1274814007228 Cu2+ binding site [ion binding]; other site 1274814007229 Zn2+ binding site [ion binding]; other site 1274814007230 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1274814007231 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1274814007232 active site 1274814007233 catalytic tetrad [active] 1274814007234 Predicted Fe-S protein [General function prediction only]; Region: COG3313 1274814007235 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 1274814007236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1274814007237 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1274814007238 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 1274814007239 FMN binding site [chemical binding]; other site 1274814007240 active site 1274814007241 substrate binding site [chemical binding]; other site 1274814007242 catalytic residue [active] 1274814007243 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 1274814007244 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 1274814007245 dimer interface [polypeptide binding]; other site 1274814007246 active site 1274814007247 metal binding site [ion binding]; metal-binding site 1274814007248 glutathione binding site [chemical binding]; other site 1274814007249 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 1274814007250 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 1274814007251 dimer interface [polypeptide binding]; other site 1274814007252 catalytic site [active] 1274814007253 putative active site [active] 1274814007254 putative substrate binding site [chemical binding]; other site 1274814007255 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1274814007256 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 1274814007257 ATP binding site [chemical binding]; other site 1274814007258 putative Mg++ binding site [ion binding]; other site 1274814007259 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1274814007260 nucleotide binding region [chemical binding]; other site 1274814007261 ATP-binding site [chemical binding]; other site 1274814007262 DEAD/H associated; Region: DEAD_assoc; pfam08494 1274814007263 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 1274814007264 putative GSH binding site [chemical binding]; other site 1274814007265 catalytic residues [active] 1274814007266 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 1274814007267 NlpC/P60 family; Region: NLPC_P60; pfam00877 1274814007268 superoxide dismutase; Provisional; Region: PRK10543 1274814007269 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 1274814007270 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 1274814007271 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814007272 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1274814007273 putative substrate translocation pore; other site 1274814007274 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 1274814007275 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814007276 DNA binding site [nucleotide binding] 1274814007277 domain linker motif; other site 1274814007278 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1274814007279 dimerization interface [polypeptide binding]; other site 1274814007280 ligand binding site [chemical binding]; other site 1274814007281 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1274814007282 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814007283 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1274814007284 dimerization interface [polypeptide binding]; other site 1274814007285 putative transporter; Provisional; Region: PRK11043 1274814007286 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814007287 putative substrate translocation pore; other site 1274814007288 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 1274814007289 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1274814007290 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814007291 S-adenosylmethionine binding site [chemical binding]; other site 1274814007292 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 1274814007293 Lumazine binding domain; Region: Lum_binding; pfam00677 1274814007294 Lumazine binding domain; Region: Lum_binding; pfam00677 1274814007295 multidrug efflux protein; Reviewed; Region: PRK01766 1274814007296 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 1274814007297 cation binding site [ion binding]; other site 1274814007298 hypothetical protein; Provisional; Region: PRK09945 1274814007299 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 1274814007300 putative monooxygenase; Provisional; Region: PRK11118 1274814007301 hypothetical protein; Provisional; Region: PRK09897 1274814007302 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 1274814007303 hypothetical protein; Provisional; Region: PRK09946 1274814007304 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 1274814007305 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 1274814007306 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 1274814007307 hypothetical protein; Provisional; Region: PRK09947 1274814007308 putative oxidoreductase; Provisional; Region: PRK09849 1274814007309 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 1274814007310 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 1274814007311 hypothetical protein; Provisional; Region: PRK09898 1274814007312 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1274814007313 hypothetical protein; Provisional; Region: PRK10292 1274814007314 pyruvate kinase; Provisional; Region: PRK09206 1274814007315 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 1274814007316 domain interfaces; other site 1274814007317 active site 1274814007318 murein lipoprotein; Provisional; Region: PRK15396 1274814007319 L,D-transpeptidase; Provisional; Region: PRK10190 1274814007320 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1274814007321 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1274814007322 cysteine desufuration protein SufE; Provisional; Region: PRK09296 1274814007323 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1274814007324 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1274814007325 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1274814007326 catalytic residue [active] 1274814007327 FeS assembly protein SufD; Region: sufD; TIGR01981 1274814007328 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 1274814007329 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 1274814007330 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 1274814007331 Walker A/P-loop; other site 1274814007332 ATP binding site [chemical binding]; other site 1274814007333 Q-loop/lid; other site 1274814007334 ABC transporter signature motif; other site 1274814007335 Walker B; other site 1274814007336 D-loop; other site 1274814007337 H-loop/switch region; other site 1274814007338 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 1274814007339 putative ABC transporter; Region: ycf24; CHL00085 1274814007340 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 1274814007341 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1274814007342 CoenzymeA binding site [chemical binding]; other site 1274814007343 subunit interaction site [polypeptide binding]; other site 1274814007344 PHB binding site; other site 1274814007345 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1274814007346 FAD binding domain; Region: FAD_binding_4; pfam01565 1274814007347 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 1274814007348 putative inner membrane protein; Provisional; Region: PRK10983 1274814007349 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1274814007350 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 1274814007351 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814007352 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1274814007353 putative substrate translocation pore; other site 1274814007354 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814007355 putative substrate translocation pore; other site 1274814007356 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 1274814007357 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1274814007358 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1274814007359 shikimate binding site; other site 1274814007360 NAD(P) binding site [chemical binding]; other site 1274814007361 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 1274814007362 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 1274814007363 active site 1274814007364 catalytic residue [active] 1274814007365 dimer interface [polypeptide binding]; other site 1274814007366 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 1274814007367 Coenzyme A transferase; Region: CoA_trans; smart00882 1274814007368 Coenzyme A transferase; Region: CoA_trans; cl17247 1274814007369 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 1274814007370 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 1274814007371 active site 1274814007372 Cupin domain; Region: Cupin_2; pfam07883 1274814007373 Winged helix DNA-binding domain (DUF1495); Region: DUF1495; cl01336 1274814007374 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1274814007375 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814007376 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1274814007377 Ligand binding site [chemical binding]; other site 1274814007378 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1274814007379 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 1274814007380 Electron transfer flavoprotein domain; Region: ETF; smart00893 1274814007381 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1274814007382 oxidoreductase; Provisional; Region: PRK10015 1274814007383 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1274814007384 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 1274814007385 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 1274814007386 acyl-activating enzyme (AAE) consensus motif; other site 1274814007387 putative AMP binding site [chemical binding]; other site 1274814007388 putative active site [active] 1274814007389 putative CoA binding site [chemical binding]; other site 1274814007390 phosphoenolpyruvate synthase; Validated; Region: PRK06464 1274814007391 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 1274814007392 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1274814007393 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1274814007394 PEP synthetase regulatory protein; Provisional; Region: PRK05339 1274814007395 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 1274814007396 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1274814007397 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 1274814007398 Uncharacterized conserved protein [Function unknown]; Region: COG0397 1274814007399 hypothetical protein; Validated; Region: PRK00029 1274814007400 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 1274814007401 NlpC/P60 family; Region: NLPC_P60; pfam00877 1274814007402 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 1274814007403 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 1274814007404 Walker A/P-loop; other site 1274814007405 ATP binding site [chemical binding]; other site 1274814007406 Q-loop/lid; other site 1274814007407 ABC transporter signature motif; other site 1274814007408 Walker B; other site 1274814007409 D-loop; other site 1274814007410 H-loop/switch region; other site 1274814007411 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 1274814007412 catalytic residues [active] 1274814007413 dimer interface [polypeptide binding]; other site 1274814007414 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 1274814007415 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1274814007416 ABC-ATPase subunit interface; other site 1274814007417 dimer interface [polypeptide binding]; other site 1274814007418 putative PBP binding regions; other site 1274814007419 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 1274814007420 IHF dimer interface [polypeptide binding]; other site 1274814007421 IHF - DNA interface [nucleotide binding]; other site 1274814007422 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 1274814007423 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 1274814007424 putative tRNA-binding site [nucleotide binding]; other site 1274814007425 B3/4 domain; Region: B3_4; pfam03483 1274814007426 tRNA synthetase B5 domain; Region: B5; smart00874 1274814007427 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 1274814007428 dimer interface [polypeptide binding]; other site 1274814007429 motif 1; other site 1274814007430 motif 3; other site 1274814007431 motif 2; other site 1274814007432 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 1274814007433 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 1274814007434 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 1274814007435 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 1274814007436 dimer interface [polypeptide binding]; other site 1274814007437 motif 1; other site 1274814007438 active site 1274814007439 motif 2; other site 1274814007440 motif 3; other site 1274814007441 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 1274814007442 23S rRNA binding site [nucleotide binding]; other site 1274814007443 L21 binding site [polypeptide binding]; other site 1274814007444 L13 binding site [polypeptide binding]; other site 1274814007445 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 1274814007446 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 1274814007447 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 1274814007448 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 1274814007449 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 1274814007450 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 1274814007451 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 1274814007452 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 1274814007453 active site 1274814007454 dimer interface [polypeptide binding]; other site 1274814007455 motif 1; other site 1274814007456 motif 2; other site 1274814007457 motif 3; other site 1274814007458 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 1274814007459 anticodon binding site; other site 1274814007460 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 1274814007461 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 1274814007462 6-phosphofructokinase 2; Provisional; Region: PRK10294 1274814007463 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1274814007464 putative substrate binding site [chemical binding]; other site 1274814007465 putative ATP binding site [chemical binding]; other site 1274814007466 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 1274814007467 Phosphotransferase enzyme family; Region: APH; pfam01636 1274814007468 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 1274814007469 active site 1274814007470 ATP binding site [chemical binding]; other site 1274814007471 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1274814007472 YniB-like protein; Region: YniB; pfam14002 1274814007473 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 1274814007474 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1274814007475 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814007476 motif II; other site 1274814007477 inner membrane protein; Provisional; Region: PRK11648 1274814007478 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 1274814007479 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1274814007480 cell division modulator; Provisional; Region: PRK10113 1274814007481 hydroperoxidase II; Provisional; Region: katE; PRK11249 1274814007482 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 1274814007483 tetramer interface [polypeptide binding]; other site 1274814007484 heme binding pocket [chemical binding]; other site 1274814007485 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 1274814007486 domain interactions; other site 1274814007487 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 1274814007488 putative active site [active] 1274814007489 YdjC motif; other site 1274814007490 Mg binding site [ion binding]; other site 1274814007491 putative homodimer interface [polypeptide binding]; other site 1274814007492 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1274814007493 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 1274814007494 NAD binding site [chemical binding]; other site 1274814007495 sugar binding site [chemical binding]; other site 1274814007496 divalent metal binding site [ion binding]; other site 1274814007497 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1274814007498 dimer interface [polypeptide binding]; other site 1274814007499 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 1274814007500 Cupin domain; Region: Cupin_2; pfam07883 1274814007501 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814007502 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 1274814007503 methionine cluster; other site 1274814007504 active site 1274814007505 phosphorylation site [posttranslational modification] 1274814007506 metal binding site [ion binding]; metal-binding site 1274814007507 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 1274814007508 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 1274814007509 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 1274814007510 active site 1274814007511 P-loop; other site 1274814007512 phosphorylation site [posttranslational modification] 1274814007513 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 1274814007514 NAD+ synthetase; Region: nadE; TIGR00552 1274814007515 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 1274814007516 homodimer interface [polypeptide binding]; other site 1274814007517 NAD binding pocket [chemical binding]; other site 1274814007518 ATP binding pocket [chemical binding]; other site 1274814007519 Mg binding site [ion binding]; other site 1274814007520 active-site loop [active] 1274814007521 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 1274814007522 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1274814007523 GIY-YIG motif/motif A; other site 1274814007524 active site 1274814007525 catalytic site [active] 1274814007526 putative DNA binding site [nucleotide binding]; other site 1274814007527 metal binding site [ion binding]; metal-binding site 1274814007528 hypothetical protein; Provisional; Region: PRK11396 1274814007529 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 1274814007530 dimer interface [polypeptide binding]; other site 1274814007531 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 1274814007532 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 1274814007533 putative active site [active] 1274814007534 Zn binding site [ion binding]; other site 1274814007535 succinylarginine dihydrolase; Provisional; Region: PRK13281 1274814007536 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 1274814007537 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 1274814007538 NAD(P) binding site [chemical binding]; other site 1274814007539 catalytic residues [active] 1274814007540 arginine succinyltransferase; Provisional; Region: PRK10456 1274814007541 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 1274814007542 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 1274814007543 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1274814007544 inhibitor-cofactor binding pocket; inhibition site 1274814007545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814007546 catalytic residue [active] 1274814007547 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 1274814007548 putative catalytic site [active] 1274814007549 putative phosphate binding site [ion binding]; other site 1274814007550 active site 1274814007551 metal binding site A [ion binding]; metal-binding site 1274814007552 DNA binding site [nucleotide binding] 1274814007553 putative AP binding site [nucleotide binding]; other site 1274814007554 putative metal binding site B [ion binding]; other site 1274814007555 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1274814007556 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1274814007557 Uncharacterized conserved protein [Function unknown]; Region: COG0398 1274814007558 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1274814007559 Uncharacterized conserved protein [Function unknown]; Region: COG2128 1274814007560 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 1274814007561 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 1274814007562 hypothetical protein; Provisional; Region: PRK11622 1274814007563 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 1274814007564 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814007565 dimer interface [polypeptide binding]; other site 1274814007566 conserved gate region; other site 1274814007567 putative PBP binding loops; other site 1274814007568 ABC-ATPase subunit interface; other site 1274814007569 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 1274814007570 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814007571 Walker A/P-loop; other site 1274814007572 ATP binding site [chemical binding]; other site 1274814007573 Q-loop/lid; other site 1274814007574 ABC transporter signature motif; other site 1274814007575 Walker B; other site 1274814007576 D-loop; other site 1274814007577 H-loop/switch region; other site 1274814007578 Rhodanese Homology Domain; Region: RHOD; smart00450 1274814007579 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 1274814007580 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1274814007581 active site residue [active] 1274814007582 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1274814007583 active site residue [active] 1274814007584 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 1274814007585 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 1274814007586 active site 1274814007587 8-oxo-dGMP binding site [chemical binding]; other site 1274814007588 nudix motif; other site 1274814007589 metal binding site [ion binding]; metal-binding site 1274814007590 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 1274814007591 glutamate dehydrogenase; Provisional; Region: PRK09414 1274814007592 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 1274814007593 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 1274814007594 NAD(P) binding site [chemical binding]; other site 1274814007595 hypothetical protein; Provisional; Region: PRK11380 1274814007596 DNA topoisomerase III; Provisional; Region: PRK07726 1274814007597 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 1274814007598 active site 1274814007599 putative interdomain interaction site [polypeptide binding]; other site 1274814007600 putative metal-binding site [ion binding]; other site 1274814007601 putative nucleotide binding site [chemical binding]; other site 1274814007602 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 1274814007603 domain I; other site 1274814007604 DNA binding groove [nucleotide binding] 1274814007605 phosphate binding site [ion binding]; other site 1274814007606 domain II; other site 1274814007607 domain III; other site 1274814007608 nucleotide binding site [chemical binding]; other site 1274814007609 catalytic site [active] 1274814007610 domain IV; other site 1274814007611 selenophosphate synthetase; Provisional; Region: PRK00943 1274814007612 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 1274814007613 dimerization interface [polypeptide binding]; other site 1274814007614 putative ATP binding site [chemical binding]; other site 1274814007615 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 1274814007616 putative FMN binding site [chemical binding]; other site 1274814007617 protease 4; Provisional; Region: PRK10949 1274814007618 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 1274814007619 tandem repeat interface [polypeptide binding]; other site 1274814007620 oligomer interface [polypeptide binding]; other site 1274814007621 active site residues [active] 1274814007622 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 1274814007623 tandem repeat interface [polypeptide binding]; other site 1274814007624 oligomer interface [polypeptide binding]; other site 1274814007625 active site residues [active] 1274814007626 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 1274814007627 active site 1274814007628 homodimer interface [polypeptide binding]; other site 1274814007629 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 1274814007630 Isochorismatase family; Region: Isochorismatase; pfam00857 1274814007631 catalytic triad [active] 1274814007632 metal binding site [ion binding]; metal-binding site 1274814007633 conserved cis-peptide bond; other site 1274814007634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 1274814007635 methionine sulfoxide reductase B; Provisional; Region: PRK00222 1274814007636 SelR domain; Region: SelR; pfam01641 1274814007637 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 1274814007638 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1274814007639 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1274814007640 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 1274814007641 active site 1274814007642 phosphate binding residues; other site 1274814007643 catalytic residues [active] 1274814007644 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1274814007645 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1274814007646 active site 1274814007647 catalytic tetrad [active] 1274814007648 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1274814007649 PrkA family serine protein kinase; Provisional; Region: PRK15455 1274814007650 AAA ATPase domain; Region: AAA_16; pfam13191 1274814007651 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 1274814007652 hypothetical protein; Provisional; Region: PRK05325 1274814007653 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1274814007654 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814007655 metal binding site [ion binding]; metal-binding site 1274814007656 active site 1274814007657 I-site; other site 1274814007658 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1274814007659 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814007660 metal binding site [ion binding]; metal-binding site 1274814007661 active site 1274814007662 I-site; other site 1274814007663 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 1274814007664 putative deacylase active site [active] 1274814007665 Predicted membrane protein [Function unknown]; Region: COG2707 1274814007666 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1274814007667 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814007668 cyanate transporter; Region: CynX; TIGR00896 1274814007669 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814007670 Uncharacterized conserved protein [Function unknown]; Region: COG3189 1274814007671 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 1274814007672 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1274814007673 Domain of unknown function (DUF333); Region: DUF333; pfam03891 1274814007674 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 1274814007675 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1274814007676 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1274814007677 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814007678 metal binding site [ion binding]; metal-binding site 1274814007679 active site 1274814007680 I-site; other site 1274814007681 hypothetical protein; Provisional; Region: PRK10457 1274814007682 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 1274814007683 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 1274814007684 leucine export protein LeuE; Provisional; Region: PRK10958 1274814007685 transcriptional activator TtdR; Provisional; Region: PRK09801 1274814007686 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814007687 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1274814007688 putative effector binding pocket; other site 1274814007689 putative dimerization interface [polypeptide binding]; other site 1274814007690 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 1274814007691 tartrate dehydrogenase; Region: TTC; TIGR02089 1274814007692 putative transporter; Provisional; Region: PRK09950 1274814007693 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1274814007694 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 1274814007695 [2Fe-2S] cluster binding site [ion binding]; other site 1274814007696 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 1274814007697 putative alpha subunit interface [polypeptide binding]; other site 1274814007698 putative active site [active] 1274814007699 putative substrate binding site [chemical binding]; other site 1274814007700 Fe binding site [ion binding]; other site 1274814007701 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 1274814007702 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 1274814007703 FMN-binding pocket [chemical binding]; other site 1274814007704 flavin binding motif; other site 1274814007705 phosphate binding motif [ion binding]; other site 1274814007706 beta-alpha-beta structure motif; other site 1274814007707 NAD binding pocket [chemical binding]; other site 1274814007708 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1274814007709 catalytic loop [active] 1274814007710 iron binding site [ion binding]; other site 1274814007711 ribonuclease D; Provisional; Region: PRK10829 1274814007712 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 1274814007713 catalytic site [active] 1274814007714 putative active site [active] 1274814007715 putative substrate binding site [chemical binding]; other site 1274814007716 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1274814007717 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 1274814007718 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 1274814007719 acyl-activating enzyme (AAE) consensus motif; other site 1274814007720 putative AMP binding site [chemical binding]; other site 1274814007721 putative active site [active] 1274814007722 putative CoA binding site [chemical binding]; other site 1274814007723 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 1274814007724 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 1274814007725 Glycoprotease family; Region: Peptidase_M22; pfam00814 1274814007726 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 1274814007727 DEAD/DEAH box helicase; Region: DEAD; pfam00270 1274814007728 DEAD_2; Region: DEAD_2; pfam06733 1274814007729 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 1274814007730 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 1274814007731 homotrimer interaction site [polypeptide binding]; other site 1274814007732 putative active site [active] 1274814007733 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 1274814007734 hypothetical protein; Provisional; Region: PRK05114 1274814007735 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 1274814007736 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 1274814007737 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 1274814007738 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 1274814007739 putative active site [active] 1274814007740 putative CoA binding site [chemical binding]; other site 1274814007741 nudix motif; other site 1274814007742 metal binding site [ion binding]; metal-binding site 1274814007743 L-serine deaminase; Provisional; Region: PRK15023 1274814007744 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1274814007745 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1274814007746 phage resistance protein; Provisional; Region: PRK10551 1274814007747 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1274814007748 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814007749 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1274814007750 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 1274814007751 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1274814007752 Transporter associated domain; Region: CorC_HlyC; smart01091 1274814007753 PTS system mannose-specific transporter subunits IIAB; Provisional; Region: PRK15088 1274814007754 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1274814007755 active pocket/dimerization site; other site 1274814007756 active site 1274814007757 phosphorylation site [posttranslational modification] 1274814007758 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1274814007759 active site 1274814007760 phosphorylation site [posttranslational modification] 1274814007761 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 1274814007762 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 1274814007763 Predicted membrane protein [Function unknown]; Region: COG4811 1274814007764 hypothetical protein; Provisional; Region: PRK11469 1274814007765 Domain of unknown function DUF; Region: DUF204; pfam02659 1274814007766 Domain of unknown function DUF; Region: DUF204; pfam02659 1274814007767 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 1274814007768 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814007769 S-adenosylmethionine binding site [chemical binding]; other site 1274814007770 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1274814007771 DNA-binding site [nucleotide binding]; DNA binding site 1274814007772 RNA-binding motif; other site 1274814007773 Protein of unknown function (DUF2627); Region: DUF2527; pfam10736 1274814007774 YebO-like protein; Region: YebO; pfam13974 1274814007775 PhoPQ regulatory protein; Provisional; Region: PRK10299 1274814007776 YobH-like protein; Region: YobH; pfam13996 1274814007777 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 1274814007778 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1274814007779 dimerization interface [polypeptide binding]; other site 1274814007780 putative Zn2+ binding site [ion binding]; other site 1274814007781 putative DNA binding site [nucleotide binding]; other site 1274814007782 Bacterial transcriptional regulator; Region: IclR; pfam01614 1274814007783 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814007784 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1274814007785 putative substrate translocation pore; other site 1274814007786 Predicted integral membrane protein [Function unknown]; Region: COG5521 1274814007787 heat shock protein HtpX; Provisional; Region: PRK05457 1274814007788 carboxy-terminal protease; Provisional; Region: PRK11186 1274814007789 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 1274814007790 protein binding site [polypeptide binding]; other site 1274814007791 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 1274814007792 Catalytic dyad [active] 1274814007793 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 1274814007794 ProP expression regulator; Provisional; Region: PRK04950 1274814007795 ProQ/FINO family; Region: ProQ; pfam04352 1274814007796 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 1274814007797 GAF domain; Region: GAF_2; pfam13185 1274814007798 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 1274814007799 Paraquat-inducible protein A; Region: PqiA; pfam04403 1274814007800 Paraquat-inducible protein A; Region: PqiA; pfam04403 1274814007801 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 1274814007802 mce related protein; Region: MCE; pfam02470 1274814007803 mce related protein; Region: MCE; pfam02470 1274814007804 mce related protein; Region: MCE; pfam02470 1274814007805 mce related protein; Region: MCE; pfam02470 1274814007806 mce related protein; Region: MCE; pfam02470 1274814007807 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 1274814007808 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814007809 S-adenosylmethionine binding site [chemical binding]; other site 1274814007810 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 1274814007811 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 1274814007812 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 1274814007813 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 1274814007814 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1274814007815 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 1274814007816 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 1274814007817 hypothetical protein; Provisional; Region: PRK10301 1274814007818 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 1274814007819 Predicted amidohydrolase [General function prediction only]; Region: COG0388 1274814007820 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 1274814007821 exodeoxyribonuclease X; Provisional; Region: PRK07983 1274814007822 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 1274814007823 active site 1274814007824 catalytic site [active] 1274814007825 substrate binding site [chemical binding]; other site 1274814007826 protease 2; Provisional; Region: PRK10115 1274814007827 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1274814007828 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 1274814007829 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 1274814007830 putative metal binding site [ion binding]; other site 1274814007831 hypothetical protein; Provisional; Region: PRK13680 1274814007832 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 1274814007833 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 1274814007834 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1274814007835 ATP-grasp domain; Region: ATP-grasp; pfam02222 1274814007836 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 1274814007837 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1274814007838 active site 1274814007839 intersubunit interface [polypeptide binding]; other site 1274814007840 catalytic residue [active] 1274814007841 phosphogluconate dehydratase; Validated; Region: PRK09054 1274814007842 6-phosphogluconate dehydratase; Region: edd; TIGR01196 1274814007843 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 1274814007844 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 1274814007845 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 1274814007846 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 1274814007847 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1274814007848 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1274814007849 putative active site [active] 1274814007850 pyruvate kinase; Provisional; Region: PRK05826 1274814007851 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cl17342 1274814007852 domain interfaces; other site 1274814007853 active site 1274814007854 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1274814007855 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1274814007856 putative acyl-acceptor binding pocket; other site 1274814007857 putative peptidase; Provisional; Region: PRK11649 1274814007858 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 1274814007859 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1274814007860 Peptidase family M23; Region: Peptidase_M23; pfam01551 1274814007861 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 1274814007862 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 1274814007863 metal binding site [ion binding]; metal-binding site 1274814007864 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 1274814007865 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 1274814007866 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 1274814007867 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 1274814007868 ABC-ATPase subunit interface; other site 1274814007869 dimer interface [polypeptide binding]; other site 1274814007870 putative PBP binding regions; other site 1274814007871 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 1274814007872 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814007873 Walker A motif; other site 1274814007874 ATP binding site [chemical binding]; other site 1274814007875 Walker B motif; other site 1274814007876 arginine finger; other site 1274814007877 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 1274814007878 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 1274814007879 RuvA N terminal domain; Region: RuvA_N; pfam01330 1274814007880 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 1274814007881 hypothetical protein; Provisional; Region: PRK11470 1274814007882 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 1274814007883 active site 1274814007884 putative DNA-binding cleft [nucleotide binding]; other site 1274814007885 dimer interface [polypeptide binding]; other site 1274814007886 hypothetical protein; Validated; Region: PRK00110 1274814007887 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 1274814007888 nudix motif; other site 1274814007889 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 1274814007890 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 1274814007891 dimer interface [polypeptide binding]; other site 1274814007892 anticodon binding site; other site 1274814007893 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1274814007894 homodimer interface [polypeptide binding]; other site 1274814007895 motif 1; other site 1274814007896 active site 1274814007897 motif 2; other site 1274814007898 GAD domain; Region: GAD; pfam02938 1274814007899 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 1274814007900 motif 3; other site 1274814007901 Isochorismatase family; Region: Isochorismatase; pfam00857 1274814007902 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 1274814007903 catalytic triad [active] 1274814007904 conserved cis-peptide bond; other site 1274814007905 hypothetical protein; Provisional; Region: PRK10302 1274814007906 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 1274814007907 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814007908 S-adenosylmethionine binding site [chemical binding]; other site 1274814007909 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814007910 S-adenosylmethionine binding site [chemical binding]; other site 1274814007911 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1274814007912 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1274814007913 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1274814007914 molybdopterin cofactor binding site [chemical binding]; other site 1274814007915 substrate binding site [chemical binding]; other site 1274814007916 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1274814007917 molybdopterin cofactor binding site; other site 1274814007918 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 1274814007919 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 1274814007920 copper homeostasis protein CutC; Provisional; Region: PRK11572 1274814007921 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 1274814007922 putative metal binding site [ion binding]; other site 1274814007923 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 1274814007924 arginyl-tRNA synthetase; Region: argS; TIGR00456 1274814007925 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 1274814007926 active site 1274814007927 HIGH motif; other site 1274814007928 KMSK motif region; other site 1274814007929 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 1274814007930 tRNA binding surface [nucleotide binding]; other site 1274814007931 anticodon binding site; other site 1274814007932 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 1274814007933 Flagellar protein FlhE; Region: FlhE; pfam06366 1274814007934 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 1274814007935 FHIPEP family; Region: FHIPEP; pfam00771 1274814007936 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 1274814007937 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 1274814007938 chemotaxis regulator CheZ; Provisional; Region: PRK11166 1274814007939 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 1274814007940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814007941 active site 1274814007942 phosphorylation site [posttranslational modification] 1274814007943 intermolecular recognition site; other site 1274814007944 dimerization interface [polypeptide binding]; other site 1274814007945 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 1274814007946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814007947 active site 1274814007948 phosphorylation site [posttranslational modification] 1274814007949 intermolecular recognition site; other site 1274814007950 dimerization interface [polypeptide binding]; other site 1274814007951 CheB methylesterase; Region: CheB_methylest; pfam01339 1274814007952 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 1274814007953 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 1274814007954 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814007955 S-adenosylmethionine binding site [chemical binding]; other site 1274814007956 methyl-accepting protein IV; Provisional; Region: PRK09793 1274814007957 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1274814007958 dimer interface [polypeptide binding]; other site 1274814007959 ligand binding site [chemical binding]; other site 1274814007960 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1274814007961 dimerization interface [polypeptide binding]; other site 1274814007962 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1274814007963 dimer interface [polypeptide binding]; other site 1274814007964 putative CheW interface [polypeptide binding]; other site 1274814007965 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 1274814007966 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 1274814007967 dimer interface [polypeptide binding]; other site 1274814007968 ligand binding site [chemical binding]; other site 1274814007969 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1274814007970 dimerization interface [polypeptide binding]; other site 1274814007971 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1274814007972 dimer interface [polypeptide binding]; other site 1274814007973 putative CheW interface [polypeptide binding]; other site 1274814007974 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 1274814007975 putative CheA interaction surface; other site 1274814007976 chemotaxis protein CheA; Provisional; Region: PRK10547 1274814007977 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1274814007978 putative binding surface; other site 1274814007979 active site 1274814007980 CheY binding; Region: CheY-binding; pfam09078 1274814007981 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 1274814007982 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814007983 ATP binding site [chemical binding]; other site 1274814007984 Mg2+ binding site [ion binding]; other site 1274814007985 G-X-G motif; other site 1274814007986 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 1274814007987 flagellar motor protein MotB; Validated; Region: motB; PRK09041 1274814007988 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 1274814007989 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1274814007990 ligand binding site [chemical binding]; other site 1274814007991 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 1274814007992 flagellar motor protein MotA; Validated; Region: PRK09110 1274814007993 transcriptional activator FlhC; Provisional; Region: PRK12722 1274814007994 transcriptional activator FlhD; Provisional; Region: PRK02909 1274814007995 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1274814007996 Ligand Binding Site [chemical binding]; other site 1274814007997 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 1274814007998 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 1274814007999 active site 1274814008000 homotetramer interface [polypeptide binding]; other site 1274814008001 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 1274814008002 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 1274814008003 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1274814008004 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1274814008005 TM-ABC transporter signature motif; other site 1274814008006 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 1274814008007 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1274814008008 Walker A/P-loop; other site 1274814008009 ATP binding site [chemical binding]; other site 1274814008010 Q-loop/lid; other site 1274814008011 ABC transporter signature motif; other site 1274814008012 Walker B; other site 1274814008013 D-loop; other site 1274814008014 H-loop/switch region; other site 1274814008015 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1274814008016 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1274814008017 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 1274814008018 ligand binding site [chemical binding]; other site 1274814008019 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1274814008020 Ferritin-like domain; Region: Ferritin; pfam00210 1274814008021 ferroxidase diiron center [ion binding]; other site 1274814008022 Protein of unknown function (DUF2766); Region: DUF2766; pfam10964 1274814008023 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 1274814008024 Ferritin-like domain; Region: Ferritin; pfam00210 1274814008025 ferroxidase diiron center [ion binding]; other site 1274814008026 probable metal-binding protein; Region: matur_matur; TIGR03853 1274814008027 tyrosine transporter TyrP; Provisional; Region: PRK15132 1274814008028 aromatic amino acid transport protein; Region: araaP; TIGR00837 1274814008029 hypothetical protein; Provisional; Region: PRK10396 1274814008030 yecA family protein; Region: ygfB_yecA; TIGR02292 1274814008031 SEC-C motif; Region: SEC-C; pfam02810 1274814008032 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 1274814008033 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 1274814008034 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 1274814008035 GIY-YIG motif/motif A; other site 1274814008036 active site 1274814008037 catalytic site [active] 1274814008038 putative DNA binding site [nucleotide binding]; other site 1274814008039 metal binding site [ion binding]; metal-binding site 1274814008040 UvrB/uvrC motif; Region: UVR; pfam02151 1274814008041 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 1274814008042 Helix-hairpin-helix motif; Region: HHH; pfam00633 1274814008043 response regulator; Provisional; Region: PRK09483 1274814008044 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814008045 active site 1274814008046 phosphorylation site [posttranslational modification] 1274814008047 intermolecular recognition site; other site 1274814008048 dimerization interface [polypeptide binding]; other site 1274814008049 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814008050 DNA binding residues [nucleotide binding] 1274814008051 dimerization interface [polypeptide binding]; other site 1274814008052 hypothetical protein; Provisional; Region: PRK10613 1274814008053 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 1274814008054 Autoinducer binding domain; Region: Autoind_bind; pfam03472 1274814008055 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814008056 DNA binding residues [nucleotide binding] 1274814008057 dimerization interface [polypeptide binding]; other site 1274814008058 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 1274814008059 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1274814008060 Walker A/P-loop; other site 1274814008061 ATP binding site [chemical binding]; other site 1274814008062 Q-loop/lid; other site 1274814008063 ABC transporter signature motif; other site 1274814008064 Walker B; other site 1274814008065 D-loop; other site 1274814008066 H-loop/switch region; other site 1274814008067 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1274814008068 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814008069 dimer interface [polypeptide binding]; other site 1274814008070 conserved gate region; other site 1274814008071 putative PBP binding loops; other site 1274814008072 ABC-ATPase subunit interface; other site 1274814008073 D-cysteine desulfhydrase; Validated; Region: PRK03910 1274814008074 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 1274814008075 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814008076 catalytic residue [active] 1274814008077 cystine transporter subunit; Provisional; Region: PRK11260 1274814008078 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814008079 substrate binding pocket [chemical binding]; other site 1274814008080 membrane-bound complex binding site; other site 1274814008081 hinge residues; other site 1274814008082 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 1274814008083 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 1274814008084 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1274814008085 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1274814008086 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1274814008087 DNA binding residues [nucleotide binding] 1274814008088 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814008089 flagellin; Validated; Region: PRK08026 1274814008090 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 1274814008091 Flagellin protein; Region: FliC; pfam12445 1274814008092 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 1274814008093 flagellar capping protein; Reviewed; Region: fliD; PRK08032 1274814008094 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 1274814008095 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 1274814008096 Flagellar protein FliS; Region: FliS; cl00654 1274814008097 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 1274814008098 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 1274814008099 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 1274814008100 active site 1274814008101 Na/Ca binding site [ion binding]; other site 1274814008102 catalytic site [active] 1274814008103 lipoprotein; Provisional; Region: PRK10397 1274814008104 putative inner membrane protein; Provisional; Region: PRK11099 1274814008105 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 1274814008106 CPxP motif; other site 1274814008107 hypothetical protein; Provisional; Region: PRK09951 1274814008108 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 1274814008109 Probable transposase; Region: OrfB_IS605; pfam01385 1274814008110 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 1274814008111 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 1274814008112 Transposase IS200 like; Region: Y1_Tnp; pfam01797 1274814008113 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1274814008114 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 1274814008115 substrate binding site [chemical binding]; other site 1274814008116 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 1274814008117 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 1274814008118 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 1274814008119 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 1274814008120 flagellar motor switch protein FliG; Region: fliG; TIGR00207 1274814008121 FliG C-terminal domain; Region: FliG_C; pfam01706 1274814008122 flagellar assembly protein H; Validated; Region: fliH; PRK05687 1274814008123 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 1274814008124 Flagellar assembly protein FliH; Region: FliH; pfam02108 1274814008125 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 1274814008126 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 1274814008127 Walker A motif/ATP binding site; other site 1274814008128 Walker B motif; other site 1274814008129 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 1274814008130 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 1274814008131 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 1274814008132 flagellar hook-length control protein; Provisional; Region: PRK10118 1274814008133 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 1274814008134 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 1274814008135 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 1274814008136 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 1274814008137 flagellar motor switch protein; Validated; Region: fliN; PRK05698 1274814008138 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 1274814008139 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 1274814008140 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 1274814008141 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 1274814008142 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 1274814008143 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814008144 DNA binding residues [nucleotide binding] 1274814008145 dimerization interface [polypeptide binding]; other site 1274814008146 hypothetical protein; Provisional; Region: PRK10708 1274814008147 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 1274814008148 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 1274814008149 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814008150 active site 1274814008151 motif I; other site 1274814008152 motif II; other site 1274814008153 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 1274814008154 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814008155 metal binding site [ion binding]; metal-binding site 1274814008156 active site 1274814008157 I-site; other site 1274814008158 Uncharacterized small protein [Function unknown]; Region: COG5475 1274814008159 hypothetical protein; Provisional; Region: PRK10062 1274814008160 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 1274814008161 EamA-like transporter family; Region: EamA; pfam00892 1274814008162 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 1274814008163 additional DNA contacts [nucleotide binding]; other site 1274814008164 mismatch recognition site; other site 1274814008165 active site 1274814008166 zinc binding site [ion binding]; other site 1274814008167 DNA intercalation site [nucleotide binding]; other site 1274814008168 DNA cytosine methylase; Provisional; Region: PRK10458 1274814008169 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 1274814008170 cofactor binding site; other site 1274814008171 DNA binding site [nucleotide binding] 1274814008172 substrate interaction site [chemical binding]; other site 1274814008173 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 1274814008174 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1274814008175 Zn2+ binding site [ion binding]; other site 1274814008176 Mg2+ binding site [ion binding]; other site 1274814008177 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 1274814008178 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1274814008179 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1274814008180 trimer interface [polypeptide binding]; other site 1274814008181 eyelet of channel; other site 1274814008182 chaperone protein HchA; Provisional; Region: PRK04155 1274814008183 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 1274814008184 dimer interface [polypeptide binding]; other site 1274814008185 metal binding site [ion binding]; metal-binding site 1274814008186 potential oxyanion hole; other site 1274814008187 potential catalytic triad [active] 1274814008188 conserved cys residue [active] 1274814008189 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 1274814008190 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814008191 dimer interface [polypeptide binding]; other site 1274814008192 phosphorylation site [posttranslational modification] 1274814008193 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814008194 ATP binding site [chemical binding]; other site 1274814008195 Mg2+ binding site [ion binding]; other site 1274814008196 G-X-G motif; other site 1274814008197 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 1274814008198 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814008199 active site 1274814008200 phosphorylation site [posttranslational modification] 1274814008201 intermolecular recognition site; other site 1274814008202 dimerization interface [polypeptide binding]; other site 1274814008203 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814008204 DNA binding site [nucleotide binding] 1274814008205 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 1274814008206 active site 1274814008207 homotetramer interface [polypeptide binding]; other site 1274814008208 TMAO/DMSO reductase; Reviewed; Region: PRK05363 1274814008209 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 1274814008210 Moco binding site; other site 1274814008211 metal coordination site [ion binding]; other site 1274814008212 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 1274814008213 zinc/cadmium-binding protein; Provisional; Region: PRK10306 1274814008214 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 1274814008215 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 1274814008216 potential frameshift: common BLAST hit: gi|82543731|ref|YP_407678.1| P4-type integrase 1274814008217 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 1274814008218 Integrase; Region: Integrase_1; pfam12835 1274814008219 Winged helix-turn-helix DNA-binding; Region: HTH_35; cl17423 1274814008220 PAAR motif; Region: PAAR_motif; cl15808 1274814008221 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 1274814008222 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1274814008223 RHS Repeat; Region: RHS_repeat; pfam05593 1274814008224 RHS Repeat; Region: RHS_repeat; pfam05593 1274814008225 RHS protein; Region: RHS; pfam03527 1274814008226 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1274814008227 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cl00107 1274814008228 putative invasin; Provisional; Region: PRK10177 1274814008229 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 1274814008230 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1274814008231 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1274814008232 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1274814008233 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1274814008234 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1274814008235 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1274814008236 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1274814008237 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1274814008238 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1274814008239 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1274814008240 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1274814008241 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1274814008242 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1274814008243 Bacterial Ig-like domain (group 1); Region: Big_1; pfam02369 1274814008244 Bacterial Ig-like domain (group 1); Region: Big_1; cl17740 1274814008245 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 1274814008246 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1274814008247 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1274814008248 shikimate transporter; Provisional; Region: PRK09952 1274814008249 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814008250 putative substrate translocation pore; other site 1274814008251 AMP nucleosidase; Provisional; Region: PRK08292 1274814008252 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 1274814008253 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 1274814008254 hypothetical protein; Provisional; Region: PRK12378 1274814008255 MATE family multidrug exporter; Provisional; Region: PRK10189 1274814008256 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 1274814008257 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 1274814008258 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814008259 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 1274814008260 putative substrate binding site [chemical binding]; other site 1274814008261 dimerization interface [polypeptide binding]; other site 1274814008262 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 1274814008263 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814008264 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 1274814008265 putative dimerization interface [polypeptide binding]; other site 1274814008266 L,D-transpeptidase; Provisional; Region: PRK10190 1274814008267 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 1274814008268 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 1274814008269 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 1274814008270 putative dimer interface [polypeptide binding]; other site 1274814008271 active site pocket [active] 1274814008272 putative cataytic base [active] 1274814008273 cobalamin 5'-phosphate synthase/cobalamin synthase; Region: cobS; TIGR00317 1274814008274 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 1274814008275 homotrimer interface [polypeptide binding]; other site 1274814008276 Walker A motif; other site 1274814008277 GTP binding site [chemical binding]; other site 1274814008278 Walker B motif; other site 1274814008279 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cl17170 1274814008280 hypothetical protein; Provisional; Region: PRK05423 1274814008281 Predicted membrane protein [Function unknown]; Region: COG1289 1274814008282 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1274814008283 DNA gyrase inhibitor; Provisional; Region: PRK10016 1274814008284 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 1274814008285 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 1274814008286 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 1274814008287 exonuclease I; Provisional; Region: sbcB; PRK11779 1274814008288 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 1274814008289 active site 1274814008290 catalytic site [active] 1274814008291 substrate binding site [chemical binding]; other site 1274814008292 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 1274814008293 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 1274814008294 CPxP motif; other site 1274814008295 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 1274814008296 Sulphur transport; Region: Sulf_transp; pfam04143 1274814008297 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 1274814008298 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814008299 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1274814008300 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1274814008301 dimerization interface [polypeptide binding]; other site 1274814008302 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1274814008303 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 1274814008304 putative NAD(P) binding site [chemical binding]; other site 1274814008305 Plasmid encoded toxin Txe; Region: Plasmid_Txe; pfam06769 1274814008306 antitoxin YefM; Provisional; Region: PRK11409 1274814008307 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 1274814008308 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 1274814008309 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 1274814008310 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 1274814008311 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 1274814008312 NAD binding site [chemical binding]; other site 1274814008313 dimerization interface [polypeptide binding]; other site 1274814008314 product binding site; other site 1274814008315 substrate binding site [chemical binding]; other site 1274814008316 zinc binding site [ion binding]; other site 1274814008317 catalytic residues [active] 1274814008318 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 1274814008319 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1274814008320 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814008321 homodimer interface [polypeptide binding]; other site 1274814008322 catalytic residue [active] 1274814008323 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 1274814008324 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814008325 active site 1274814008326 motif I; other site 1274814008327 motif II; other site 1274814008328 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 1274814008329 putative active site pocket [active] 1274814008330 4-fold oligomerization interface [polypeptide binding]; other site 1274814008331 metal binding residues [ion binding]; metal-binding site 1274814008332 3-fold/trimer interface [polypeptide binding]; other site 1274814008333 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 1274814008334 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 1274814008335 putative active site [active] 1274814008336 oxyanion strand; other site 1274814008337 catalytic triad [active] 1274814008338 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 1274814008339 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 1274814008340 catalytic residues [active] 1274814008341 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 1274814008342 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 1274814008343 substrate binding site [chemical binding]; other site 1274814008344 glutamase interaction surface [polypeptide binding]; other site 1274814008345 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 1274814008346 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 1274814008347 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 1274814008348 metal binding site [ion binding]; metal-binding site 1274814008349 chain length determinant protein WzzB; Provisional; Region: PRK15471 1274814008350 Chain length determinant protein; Region: Wzz; pfam02706 1274814008351 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 1274814008352 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1274814008353 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1274814008354 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1274814008355 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1274814008356 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 1274814008357 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 1274814008358 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1274814008359 active site 1274814008360 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 1274814008361 substrate binding site [chemical binding]; other site 1274814008362 capsule biosynthesis phosphatase; Region: EcbF-BcbF; TIGR01689 1274814008363 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1274814008364 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1274814008365 WavE lipopolysaccharide synthesis; Region: WavE; pfam07507 1274814008366 phosphomannomutase CpsG; Provisional; Region: PRK15414 1274814008367 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1274814008368 active site 1274814008369 substrate binding site [chemical binding]; other site 1274814008370 metal binding site [ion binding]; metal-binding site 1274814008371 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1274814008372 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1274814008373 Substrate binding site; other site 1274814008374 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1274814008375 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1274814008376 This family is most closely related to the GT1 family of glycosyltransferases. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can...; Region: GT1_like_4; cd03795 1274814008377 putative ADP-binding pocket [chemical binding]; other site 1274814008378 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1274814008379 Glycosyl transferases group 1; Region: Glyco_trans_1_4; pfam13692 1274814008380 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 1274814008381 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 1274814008382 active site 1274814008383 tetramer interface; other site 1274814008384 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 1274814008385 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 1274814008386 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 1274814008387 putative ADP-binding pocket [chemical binding]; other site 1274814008388 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 1274814008389 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 1274814008390 colanic acid exporter; Provisional; Region: PRK10459 1274814008391 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 1274814008392 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 1274814008393 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 1274814008394 phosphomannomutase CpsG; Provisional; Region: PRK15414 1274814008395 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 1274814008396 active site 1274814008397 substrate binding site [chemical binding]; other site 1274814008398 metal binding site [ion binding]; metal-binding site 1274814008399 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 1274814008400 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 1274814008401 Substrate binding site; other site 1274814008402 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 1274814008403 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 1274814008404 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 1274814008405 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 1274814008406 active site 1274814008407 GDP-Mannose binding site [chemical binding]; other site 1274814008408 dimer interface [polypeptide binding]; other site 1274814008409 modified nudix motif 1274814008410 metal binding site [ion binding]; metal-binding site 1274814008411 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 1274814008412 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 1274814008413 NADP binding site [chemical binding]; other site 1274814008414 active site 1274814008415 putative substrate binding site [chemical binding]; other site 1274814008416 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 1274814008417 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 1274814008418 NADP-binding site; other site 1274814008419 homotetramer interface [polypeptide binding]; other site 1274814008420 substrate binding site [chemical binding]; other site 1274814008421 homodimer interface [polypeptide binding]; other site 1274814008422 active site 1274814008423 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 1274814008424 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 1274814008425 putative trimer interface [polypeptide binding]; other site 1274814008426 putative active site [active] 1274814008427 putative substrate binding site [chemical binding]; other site 1274814008428 putative CoA binding site [chemical binding]; other site 1274814008429 putative glycosyl transferase; Provisional; Region: PRK10063 1274814008430 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 1274814008431 metal-binding site 1274814008432 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 1274814008433 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1274814008434 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 1274814008435 putative acyl transferase; Provisional; Region: PRK10191 1274814008436 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1274814008437 trimer interface [polypeptide binding]; other site 1274814008438 active site 1274814008439 substrate binding site [chemical binding]; other site 1274814008440 CoA binding site [chemical binding]; other site 1274814008441 putative glycosyl transferase; Provisional; Region: PRK10018 1274814008442 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 1274814008443 active site 1274814008444 tyrosine kinase; Provisional; Region: PRK11519 1274814008445 Chain length determinant protein; Region: Wzz; pfam02706 1274814008446 Chain length determinant protein; Region: Wzz; cl15801 1274814008447 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 1274814008448 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1274814008449 Low molecular weight phosphatase family; Region: LMWPc; cd00115 1274814008450 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 1274814008451 active site 1274814008452 polysaccharide export protein Wza; Provisional; Region: PRK15078 1274814008453 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 1274814008454 SLBB domain; Region: SLBB; pfam10531 1274814008455 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1274814008456 FOG: CBS domain [General function prediction only]; Region: COG0517 1274814008457 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1274814008458 Transporter associated domain; Region: CorC_HlyC; smart01091 1274814008459 putative assembly protein; Provisional; Region: PRK10833 1274814008460 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1274814008461 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1274814008462 trimer interface [polypeptide binding]; other site 1274814008463 active site 1274814008464 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 1274814008465 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 1274814008466 ATP-binding site [chemical binding]; other site 1274814008467 Sugar specificity; other site 1274814008468 Pyrimidine base specificity; other site 1274814008469 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 1274814008470 putative diguanylate cyclase; Provisional; Region: PRK09776 1274814008471 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1274814008472 putative active site [active] 1274814008473 heme pocket [chemical binding]; other site 1274814008474 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1274814008475 putative active site [active] 1274814008476 heme pocket [chemical binding]; other site 1274814008477 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1274814008478 putative active site [active] 1274814008479 heme pocket [chemical binding]; other site 1274814008480 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814008481 metal binding site [ion binding]; metal-binding site 1274814008482 active site 1274814008483 I-site; other site 1274814008484 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814008485 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 1274814008486 AlkA N-terminal domain; Region: AlkA_N; smart01009 1274814008487 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1274814008488 minor groove reading motif; other site 1274814008489 helix-hairpin-helix signature motif; other site 1274814008490 substrate binding pocket [chemical binding]; other site 1274814008491 active site 1274814008492 putative chaperone; Provisional; Region: PRK11678 1274814008493 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 1274814008494 nucleotide binding site [chemical binding]; other site 1274814008495 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1274814008496 SBD interface [polypeptide binding]; other site 1274814008497 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 1274814008498 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 1274814008499 substrate binding site [chemical binding]; other site 1274814008500 activation loop (A-loop); other site 1274814008501 Y-family of DNA polymerases; Region: PolY; cl12025 1274814008502 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3779 1274814008503 Uncharacterized protein conserved in bacteria (DUF2314); Region: DUF2314; pfam10077 1274814008504 Protein phosphatase 2C; Region: PP2C_2; pfam13672 1274814008505 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 1274814008506 metal ion-dependent adhesion site (MIDAS); other site 1274814008507 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 1274814008508 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1274814008509 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814008510 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 1274814008511 Protein export membrane protein; Region: SecD_SecF; cl14618 1274814008512 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 1274814008513 putative transporter; Provisional; Region: PRK10504 1274814008514 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814008515 putative substrate translocation pore; other site 1274814008516 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814008517 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 1274814008518 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1274814008519 dimerization interface [polypeptide binding]; other site 1274814008520 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814008521 dimer interface [polypeptide binding]; other site 1274814008522 phosphorylation site [posttranslational modification] 1274814008523 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814008524 ATP binding site [chemical binding]; other site 1274814008525 Mg2+ binding site [ion binding]; other site 1274814008526 G-X-G motif; other site 1274814008527 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 1274814008528 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814008529 active site 1274814008530 phosphorylation site [posttranslational modification] 1274814008531 intermolecular recognition site; other site 1274814008532 dimerization interface [polypeptide binding]; other site 1274814008533 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814008534 DNA binding site [nucleotide binding] 1274814008535 Uncharacterized conserved protein [Function unknown]; Region: COG3422 1274814008536 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 1274814008537 putative addiction module antidote protein, CC2985 family; Region: antidote_CC2985; TIGR02606 1274814008538 Plasmid stabilization system protein [General function prediction only]; Region: ParE; COG3668 1274814008539 putative protease; Provisional; Region: PRK15452 1274814008540 Peptidase family U32; Region: Peptidase_U32; pfam01136 1274814008541 lipid kinase; Reviewed; Region: PRK13054 1274814008542 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 1274814008543 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1274814008544 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1274814008545 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1274814008546 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 1274814008547 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 1274814008548 putative NAD(P) binding site [chemical binding]; other site 1274814008549 catalytic Zn binding site [ion binding]; other site 1274814008550 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 1274814008551 PTS system, galactitol-specific IIC component; Region: EIIC-GAT; TIGR00827 1274814008552 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 1274814008553 active site 1274814008554 P-loop; other site 1274814008555 phosphorylation site [posttranslational modification] 1274814008556 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1274814008557 active site 1274814008558 phosphorylation site [posttranslational modification] 1274814008559 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 1274814008560 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 1274814008561 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1274814008562 intersubunit interface [polypeptide binding]; other site 1274814008563 active site 1274814008564 zinc binding site [ion binding]; other site 1274814008565 Na+ binding site [ion binding]; other site 1274814008566 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 1274814008567 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 1274814008568 putative active site; other site 1274814008569 catalytic residue [active] 1274814008570 nucleoside transporter; Region: 2A0110; TIGR00889 1274814008571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814008572 putative substrate translocation pore; other site 1274814008573 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 1274814008574 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1274814008575 ribokinase/pfkB superfamily: Kinases that accept a wide variety of substrates, including carbohydrates and aromatic small molecules, all are phosphorylated at a hydroxyl group. The superfamily includes ribokinase, fructokinase, ketohexokinase; Region: ribokinase_pfkB_like; cl00192 1274814008576 substrate binding site [chemical binding]; other site 1274814008577 ATP binding site [chemical binding]; other site 1274814008578 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1274814008579 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814008580 DNA-binding site [nucleotide binding]; DNA binding site 1274814008581 UTRA domain; Region: UTRA; pfam07702 1274814008582 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 1274814008583 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 1274814008584 active site 1274814008585 Endo-N-acetylmuramidases (muramidases) are lysozymes (also referred to as peptidoglycan hydrolases) that degrade bacterial cell walls by catalyzing the hydrolysis of 1,4-beta-linkages between N-acetylmuramic acid and N-acetyl-D-glucosamine residues; Region: GH25_muramidase; cl10448 1274814008586 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 1274814008587 dimer interface [polypeptide binding]; other site 1274814008588 substrate binding site [chemical binding]; other site 1274814008589 ATP binding site [chemical binding]; other site 1274814008590 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 1274814008591 substrate binding site [chemical binding]; other site 1274814008592 multimerization interface [polypeptide binding]; other site 1274814008593 ATP binding site [chemical binding]; other site 1274814008594 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 1274814008595 putative metal binding site [ion binding]; other site 1274814008596 putative homodimer interface [polypeptide binding]; other site 1274814008597 putative homotetramer interface [polypeptide binding]; other site 1274814008598 putative homodimer-homodimer interface [polypeptide binding]; other site 1274814008599 putative allosteric switch controlling residues; other site 1274814008600 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 1274814008601 Predicted integral membrane protein [Function unknown]; Region: COG5455 1274814008602 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 1274814008603 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 1274814008604 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 1274814008605 PapC N-terminal domain; Region: PapC_N; pfam13954 1274814008606 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1274814008607 PapC C-terminal domain; Region: PapC_C; pfam13953 1274814008608 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 1274814008609 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1274814008610 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1274814008611 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1274814008612 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 1274814008613 antiporter inner membrane protein; Provisional; Region: PRK11670 1274814008614 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 1274814008615 Walker A motif; other site 1274814008616 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 1274814008617 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 1274814008618 active site 1274814008619 HIGH motif; other site 1274814008620 KMSKS motif; other site 1274814008621 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 1274814008622 tRNA binding surface [nucleotide binding]; other site 1274814008623 anticodon binding site; other site 1274814008624 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 1274814008625 dimer interface [polypeptide binding]; other site 1274814008626 putative tRNA-binding site [nucleotide binding]; other site 1274814008627 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 1274814008628 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 1274814008629 potential frameshift: common BLAST hit: gi|209919576|ref|YP_002293660.1| putative regulator 1274814008630 MoxR-like ATPases [General function prediction only]; Region: COG0714 1274814008631 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814008632 Walker A motif; other site 1274814008633 ATP binding site [chemical binding]; other site 1274814008634 Walker B motif; other site 1274814008635 arginine finger; other site 1274814008636 VWA domain containing CoxE-like protein; Region: VWA_CoxE; pfam05762 1274814008637 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1274814008638 metal ion-dependent adhesion site (MIDAS); other site 1274814008639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 1274814008640 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 1274814008641 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1274814008642 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 1274814008643 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 1274814008644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814008645 active site 1274814008646 phosphorylation site [posttranslational modification] 1274814008647 intermolecular recognition site; other site 1274814008648 dimerization interface [polypeptide binding]; other site 1274814008649 LytTr DNA-binding domain; Region: LytTR; pfam04397 1274814008650 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1274814008651 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1274814008652 GAF domain; Region: GAF; pfam01590 1274814008653 Histidine kinase; Region: His_kinase; pfam06580 1274814008654 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814008655 ATP binding site [chemical binding]; other site 1274814008656 Mg2+ binding site [ion binding]; other site 1274814008657 G-X-G motif; other site 1274814008658 transcriptional regulator MirA; Provisional; Region: PRK15043 1274814008659 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 1274814008660 DNA binding residues [nucleotide binding] 1274814008661 hypothetical protein; Provisional; Region: PRK13681 1274814008662 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 1274814008663 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814008664 dimer interface [polypeptide binding]; other site 1274814008665 conserved gate region; other site 1274814008666 putative PBP binding loops; other site 1274814008667 ABC-ATPase subunit interface; other site 1274814008668 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 1274814008669 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 1274814008670 Walker A/P-loop; other site 1274814008671 ATP binding site [chemical binding]; other site 1274814008672 Q-loop/lid; other site 1274814008673 ABC transporter signature motif; other site 1274814008674 Walker B; other site 1274814008675 D-loop; other site 1274814008676 H-loop/switch region; other site 1274814008677 The CBS domain, named after human CBS, is a small domain originally identified in cystathionine beta-synthase and is subsequently found in a wide range of different proteins. CBS domains usually occur in tandem repeats. They associate to form a so-called...; Region: CBS_pair; cd02205 1274814008678 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814008679 dimer interface [polypeptide binding]; other site 1274814008680 conserved gate region; other site 1274814008681 ABC-ATPase subunit interface; other site 1274814008682 Periplasmic glycine betaine/choline-binding (lipo)protein of an ABC-type transport system (osmoprotectant binding protein) [Cell envelope biogenesis, outer membrane]; Region: OpuBC; COG1732 1274814008683 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 1274814008684 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 1274814008685 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 1274814008686 D-lactate dehydrogenase; Provisional; Region: PRK11183 1274814008687 FAD binding domain; Region: FAD_binding_4; pfam01565 1274814008688 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 1274814008689 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 1274814008690 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 1274814008691 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 1274814008692 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1274814008693 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 1274814008694 oxidoreductase; Provisional; Region: PRK12743 1274814008695 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1274814008696 NAD(P) binding site [chemical binding]; other site 1274814008697 active site 1274814008698 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 1274814008699 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 1274814008700 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1274814008701 FMN binding site [chemical binding]; other site 1274814008702 active site 1274814008703 catalytic residues [active] 1274814008704 substrate binding site [chemical binding]; other site 1274814008705 hypothetical protein; Provisional; Region: PRK01821 1274814008706 hypothetical protein; Provisional; Region: PRK10711 1274814008707 cytidine deaminase; Provisional; Region: PRK09027 1274814008708 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1274814008709 active site 1274814008710 catalytic motif [active] 1274814008711 Zn binding site [ion binding]; other site 1274814008712 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 1274814008713 active site 1274814008714 catalytic motif [active] 1274814008715 Zn binding site [ion binding]; other site 1274814008716 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1274814008717 putative active site [active] 1274814008718 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 1274814008719 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 1274814008720 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1274814008721 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1274814008722 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 1274814008723 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 1274814008724 homodimer interface [polypeptide binding]; other site 1274814008725 active site 1274814008726 FMN binding site [chemical binding]; other site 1274814008727 substrate binding site [chemical binding]; other site 1274814008728 4Fe-4S binding domain; Region: Fer4; pfam00037 1274814008729 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1274814008730 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1274814008731 TM-ABC transporter signature motif; other site 1274814008732 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1274814008733 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 1274814008734 Walker A/P-loop; other site 1274814008735 ATP binding site [chemical binding]; other site 1274814008736 Q-loop/lid; other site 1274814008737 ABC transporter signature motif; other site 1274814008738 Walker B; other site 1274814008739 D-loop; other site 1274814008740 H-loop/switch region; other site 1274814008741 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1274814008742 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 1274814008743 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 1274814008744 ligand binding site [chemical binding]; other site 1274814008745 calcium binding site [ion binding]; other site 1274814008746 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 1274814008747 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814008748 DNA binding site [nucleotide binding] 1274814008749 domain linker motif; other site 1274814008750 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1274814008751 dimerization interface (closed form) [polypeptide binding]; other site 1274814008752 ligand binding site [chemical binding]; other site 1274814008753 Predicted membrane protein [Function unknown]; Region: COG2311 1274814008754 hypothetical protein; Provisional; Region: PRK10835 1274814008755 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 1274814008756 homodecamer interface [polypeptide binding]; other site 1274814008757 GTP cyclohydrolase I; Provisional; Region: PLN03044 1274814008758 active site 1274814008759 putative catalytic site residues [active] 1274814008760 zinc binding site [ion binding]; other site 1274814008761 GTP-CH-I/GFRP interaction surface; other site 1274814008762 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 1274814008763 S-formylglutathione hydrolase; Region: PLN02442 1274814008764 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1274814008765 ligand-binding site [chemical binding]; other site 1274814008766 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 1274814008767 N-terminal plug; other site 1274814008768 lysine transporter; Provisional; Region: PRK10836 1274814008769 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 1274814008770 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814008771 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 1274814008772 putative dimerization interface [polypeptide binding]; other site 1274814008773 conserved hypothetical integral membrane protein; Region: TIGR00698 1274814008774 endonuclease IV; Provisional; Region: PRK01060 1274814008775 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1274814008776 AP (apurinic/apyrimidinic) site pocket; other site 1274814008777 DNA interaction; other site 1274814008778 Metal-binding active site; metal-binding site 1274814008779 putative kinase; Provisional; Region: PRK09954 1274814008780 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1274814008781 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1274814008782 substrate binding site [chemical binding]; other site 1274814008783 ATP binding site [chemical binding]; other site 1274814008784 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1274814008785 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1274814008786 Nucleoside recognition; Region: Gate; pfam07670 1274814008787 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1274814008788 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 1274814008789 active site 1274814008790 tetramer interface [polypeptide binding]; other site 1274814008791 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 1274814008792 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1274814008793 ligand binding site [chemical binding]; other site 1274814008794 flexible hinge region; other site 1274814008795 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 1274814008796 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1274814008797 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1274814008798 Nucleoside recognition; Region: Gate; pfam07670 1274814008799 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1274814008800 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 1274814008801 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 1274814008802 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1274814008803 substrate binding site [chemical binding]; other site 1274814008804 ATP binding site [chemical binding]; other site 1274814008805 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 1274814008806 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 1274814008807 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1274814008808 active site 1274814008809 P-loop; other site 1274814008810 phosphorylation site [posttranslational modification] 1274814008811 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 1274814008812 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 1274814008813 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 1274814008814 putative substrate binding site [chemical binding]; other site 1274814008815 putative ATP binding site [chemical binding]; other site 1274814008816 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 1274814008817 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1274814008818 active site 1274814008819 phosphorylation site [posttranslational modification] 1274814008820 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1274814008821 dimerization domain swap beta strand [polypeptide binding]; other site 1274814008822 regulatory protein interface [polypeptide binding]; other site 1274814008823 active site 1274814008824 regulatory phosphorylation site [posttranslational modification]; other site 1274814008825 sugar efflux transporter B; Provisional; Region: PRK15011 1274814008826 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814008827 putative substrate translocation pore; other site 1274814008828 Flagellin N-methylase; Region: FliB; pfam03692 1274814008829 elongation factor P; Provisional; Region: PRK04542 1274814008830 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 1274814008831 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 1274814008832 RNA binding site [nucleotide binding]; other site 1274814008833 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 1274814008834 RNA binding site [nucleotide binding]; other site 1274814008835 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 1274814008836 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1274814008837 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1274814008838 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 1274814008839 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 1274814008840 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 1274814008841 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 1274814008842 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 1274814008843 active site 1274814008844 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 1274814008845 NlpC/P60 family; Region: NLPC_P60; pfam00877 1274814008846 phage resistance protein; Provisional; Region: PRK10551 1274814008847 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 1274814008848 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814008849 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 1274814008850 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 1274814008851 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 1274814008852 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814008853 dimer interface [polypeptide binding]; other site 1274814008854 conserved gate region; other site 1274814008855 putative PBP binding loops; other site 1274814008856 ABC-ATPase subunit interface; other site 1274814008857 microcin C ABC transporter permease; Provisional; Region: PRK15021 1274814008858 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814008859 dimer interface [polypeptide binding]; other site 1274814008860 conserved gate region; other site 1274814008861 ABC-ATPase subunit interface; other site 1274814008862 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 1274814008863 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814008864 Walker A/P-loop; other site 1274814008865 ATP binding site [chemical binding]; other site 1274814008866 Q-loop/lid; other site 1274814008867 ABC transporter signature motif; other site 1274814008868 Walker B; other site 1274814008869 D-loop; other site 1274814008870 H-loop/switch region; other site 1274814008871 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1274814008872 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814008873 Walker A/P-loop; other site 1274814008874 ATP binding site [chemical binding]; other site 1274814008875 Q-loop/lid; other site 1274814008876 ABC transporter signature motif; other site 1274814008877 Walker B; other site 1274814008878 D-loop; other site 1274814008879 H-loop/switch region; other site 1274814008880 hypothetical protein; Provisional; Region: PRK11835 1274814008881 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814008882 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 1274814008883 putative substrate translocation pore; other site 1274814008884 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 1274814008885 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1274814008886 RNA binding surface [nucleotide binding]; other site 1274814008887 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 1274814008888 active site 1274814008889 uracil binding [chemical binding]; other site 1274814008890 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 1274814008891 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1274814008892 ATP binding site [chemical binding]; other site 1274814008893 putative Mg++ binding site [ion binding]; other site 1274814008894 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1274814008895 nucleotide binding region [chemical binding]; other site 1274814008896 ATP-binding site [chemical binding]; other site 1274814008897 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 1274814008898 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 1274814008899 5S rRNA interface [nucleotide binding]; other site 1274814008900 CTC domain interface [polypeptide binding]; other site 1274814008901 L16 interface [polypeptide binding]; other site 1274814008902 Nucleoid-associated protein [General function prediction only]; Region: COG3081 1274814008903 nucleoid-associated protein NdpA; Validated; Region: PRK00378 1274814008904 hypothetical protein; Provisional; Region: PRK13689 1274814008905 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 1274814008906 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 1274814008907 Sulfatase; Region: Sulfatase; pfam00884 1274814008908 DinI-like family; Region: DinI; cl11630 1274814008909 IS2 repressor TnpA; Reviewed; Region: PRK09413 1274814008910 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814008911 IS2 transposase TnpB; Reviewed; Region: PRK09409 1274814008912 HTH-like domain; Region: HTH_21; pfam13276 1274814008913 Integrase core domain; Region: rve; pfam00665 1274814008914 Integrase core domain; Region: rve_3; pfam13683 1274814008915 Uncharacterized conserved protein [Function unknown]; Region: COG1479 1274814008916 Protein of unknown function DUF262; Region: DUF262; pfam03235 1274814008917 Protein of unknown function DUF262; Region: DUF262; pfam03235 1274814008918 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 1274814008919 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1274814008920 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cl02788 1274814008921 catalytic nucleophile [active] 1274814008922 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1274814008923 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 1274814008924 Predicted chitinase [General function prediction only]; Region: COG3179 1274814008925 catalytic residue [active] 1274814008926 Protein of unknown function (DUF754); Region: DUF754; pfam05449 1274814008927 DNA N-6-adenine-methyltransferase (Dam); Region: Dam; cl05442 1274814008928 Uncharacterized conserved protein (DUF2303); Region: DUF2303; cl02338 1274814008929 Predicted hydrolases of HD superfamily [General function prediction only]; Region: COG1896 1274814008930 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 1274814008931 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1274814008932 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1274814008933 active site 1274814008934 DNA binding site [nucleotide binding] 1274814008935 Int/Topo IB signature motif; other site 1274814008936 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 1274814008937 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 1274814008938 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1274814008939 transcriptional regulator NarP; Provisional; Region: PRK10403 1274814008940 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814008941 active site 1274814008942 phosphorylation site [posttranslational modification] 1274814008943 intermolecular recognition site; other site 1274814008944 dimerization interface [polypeptide binding]; other site 1274814008945 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814008946 DNA binding residues [nucleotide binding] 1274814008947 dimerization interface [polypeptide binding]; other site 1274814008948 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 1274814008949 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 1274814008950 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1274814008951 binding surface 1274814008952 TPR motif; other site 1274814008953 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 1274814008954 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 1274814008955 catalytic residues [active] 1274814008956 central insert; other site 1274814008957 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 1274814008958 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 1274814008959 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 1274814008960 heme exporter protein CcmC; Region: ccmC; TIGR01191 1274814008961 heme exporter protein CcmB; Region: ccmB; TIGR01190 1274814008962 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 1274814008963 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 1274814008964 Walker A/P-loop; other site 1274814008965 ATP binding site [chemical binding]; other site 1274814008966 Q-loop/lid; other site 1274814008967 ABC transporter signature motif; other site 1274814008968 Walker B; other site 1274814008969 D-loop; other site 1274814008970 H-loop/switch region; other site 1274814008971 cytochrome c-type protein NapC; Provisional; Region: PRK10617 1274814008972 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 1274814008973 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 1274814008974 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 1274814008975 4Fe-4S binding domain; Region: Fer4_5; pfam12801 1274814008976 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1274814008977 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 1274814008978 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 1274814008979 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 1274814008980 [4Fe-4S] binding site [ion binding]; other site 1274814008981 molybdopterin cofactor binding site; other site 1274814008982 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 1274814008983 molybdopterin cofactor binding site; other site 1274814008984 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 1274814008985 ferredoxin-type protein; Provisional; Region: PRK10194 1274814008986 tRNA synthetases class I (R); Region: tRNA-synt_1d; pfam00750 1274814008987 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 1274814008988 secondary substrate binding site; other site 1274814008989 primary substrate binding site; other site 1274814008990 inhibition loop; other site 1274814008991 dimerization interface [polypeptide binding]; other site 1274814008992 malate:quinone oxidoreductase; Validated; Region: PRK05257 1274814008993 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 1274814008994 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 1274814008995 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 1274814008996 Walker A/P-loop; other site 1274814008997 ATP binding site [chemical binding]; other site 1274814008998 Q-loop/lid; other site 1274814008999 ABC transporter signature motif; other site 1274814009000 Walker B; other site 1274814009001 D-loop; other site 1274814009002 H-loop/switch region; other site 1274814009003 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 1274814009004 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 1274814009005 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 1274814009006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814009007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814009008 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 1274814009009 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 1274814009010 DNA binding site [nucleotide binding] 1274814009011 active site 1274814009012 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 1274814009013 ApbE family; Region: ApbE; pfam02424 1274814009014 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 1274814009015 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 1274814009016 trimer interface [polypeptide binding]; other site 1274814009017 eyelet of channel; other site 1274814009018 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 1274814009019 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814009020 ATP binding site [chemical binding]; other site 1274814009021 G-X-G motif; other site 1274814009022 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1274814009023 putative binding surface; other site 1274814009024 active site 1274814009025 transcriptional regulator RcsB; Provisional; Region: PRK10840 1274814009026 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814009027 active site 1274814009028 phosphorylation site [posttranslational modification] 1274814009029 intermolecular recognition site; other site 1274814009030 dimerization interface [polypeptide binding]; other site 1274814009031 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814009032 DNA binding residues [nucleotide binding] 1274814009033 dimerization interface [polypeptide binding]; other site 1274814009034 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 1274814009035 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814009036 dimer interface [polypeptide binding]; other site 1274814009037 phosphorylation site [posttranslational modification] 1274814009038 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814009039 ATP binding site [chemical binding]; other site 1274814009040 Mg2+ binding site [ion binding]; other site 1274814009041 G-X-G motif; other site 1274814009042 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 1274814009043 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814009044 active site 1274814009045 phosphorylation site [posttranslational modification] 1274814009046 intermolecular recognition site; other site 1274814009047 dimerization interface [polypeptide binding]; other site 1274814009048 sensory histidine kinase AtoS; Provisional; Region: PRK11360 1274814009049 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1274814009050 putative active site [active] 1274814009051 heme pocket [chemical binding]; other site 1274814009052 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814009053 dimer interface [polypeptide binding]; other site 1274814009054 phosphorylation site [posttranslational modification] 1274814009055 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814009056 ATP binding site [chemical binding]; other site 1274814009057 Mg2+ binding site [ion binding]; other site 1274814009058 G-X-G motif; other site 1274814009059 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 1274814009060 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814009061 active site 1274814009062 phosphorylation site [posttranslational modification] 1274814009063 intermolecular recognition site; other site 1274814009064 dimerization interface [polypeptide binding]; other site 1274814009065 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814009066 Walker A motif; other site 1274814009067 ATP binding site [chemical binding]; other site 1274814009068 Walker B motif; other site 1274814009069 arginine finger; other site 1274814009070 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1274814009071 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 1274814009072 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 1274814009073 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 1274814009074 putative acyltransferase; Provisional; Region: PRK05790 1274814009075 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1274814009076 dimer interface [polypeptide binding]; other site 1274814009077 active site 1274814009078 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 1274814009079 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 1274814009080 Predicted secreted protein [Function unknown]; Region: COG5445 1274814009081 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1274814009082 Predicted secreted protein [Function unknown]; Region: COG5445 1274814009083 Stage II sporulation protein; Region: SpoIID; pfam08486 1274814009084 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 1274814009085 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1274814009086 MG2 domain; Region: A2M_N; pfam01835 1274814009087 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 1274814009088 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1274814009089 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 1274814009090 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 1274814009091 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 1274814009092 DNA gyrase subunit A; Validated; Region: PRK05560 1274814009093 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1274814009094 CAP-like domain; other site 1274814009095 active site 1274814009096 primary dimer interface [polypeptide binding]; other site 1274814009097 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1274814009098 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1274814009099 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1274814009100 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1274814009101 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1274814009102 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1274814009103 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 1274814009104 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814009105 S-adenosylmethionine binding site [chemical binding]; other site 1274814009106 adhesin; Provisional; Region: PRK09752 1274814009107 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 1274814009108 Autotransporter beta-domain; Region: Autotransporter; pfam03797 1274814009109 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 1274814009110 ATP cone domain; Region: ATP-cone; pfam03477 1274814009111 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1274814009112 active site 1274814009113 dimer interface [polypeptide binding]; other site 1274814009114 catalytic residues [active] 1274814009115 effector binding site; other site 1274814009116 R2 peptide binding site; other site 1274814009117 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1274814009118 dimer interface [polypeptide binding]; other site 1274814009119 putative radical transfer pathway; other site 1274814009120 diiron center [ion binding]; other site 1274814009121 tyrosyl radical; other site 1274814009122 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1274814009123 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1274814009124 catalytic loop [active] 1274814009125 iron binding site [ion binding]; other site 1274814009126 hypothetical protein; Provisional; Region: PRK09902 1274814009127 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1274814009128 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 1274814009129 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 1274814009130 active site 1274814009131 catalytic site [active] 1274814009132 metal binding site [ion binding]; metal-binding site 1274814009133 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 1274814009134 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814009135 putative substrate translocation pore; other site 1274814009136 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 1274814009137 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1274814009138 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1274814009139 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 1274814009140 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 1274814009141 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 1274814009142 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1274814009143 Cysteine-rich domain; Region: CCG; pfam02754 1274814009144 Cysteine-rich domain; Region: CCG; pfam02754 1274814009145 hypothetical protein; Provisional; Region: PRK09956 1274814009146 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1274814009147 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 1274814009148 hypothetical protein; Provisional; Region: PRK03673 1274814009149 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 1274814009150 putative MPT binding site; other site 1274814009151 Competence-damaged protein; Region: CinA; cl00666 1274814009152 YfaZ precursor; Region: YfaZ; pfam07437 1274814009153 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 1274814009154 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 1274814009155 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 1274814009156 catalytic core [active] 1274814009157 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1274814009158 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1274814009159 inhibitor-cofactor binding pocket; inhibition site 1274814009160 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814009161 catalytic residue [active] 1274814009162 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 1274814009163 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 1274814009164 Ligand binding site; other site 1274814009165 Putative Catalytic site; other site 1274814009166 DXD motif; other site 1274814009167 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 1274814009168 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 1274814009169 substrate binding site [chemical binding]; other site 1274814009170 cosubstrate binding site; other site 1274814009171 catalytic site [active] 1274814009172 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 1274814009173 active site 1274814009174 hexamer interface [polypeptide binding]; other site 1274814009175 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 1274814009176 NAD binding site [chemical binding]; other site 1274814009177 substrate binding site [chemical binding]; other site 1274814009178 active site 1274814009179 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 1274814009180 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 1274814009181 putative active site [active] 1274814009182 putative catalytic site [active] 1274814009183 putative Zn binding site [ion binding]; other site 1274814009184 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 1274814009185 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 1274814009186 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 1274814009187 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 1274814009188 signal transduction protein PmrD; Provisional; Region: PRK15450 1274814009189 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 1274814009190 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 1274814009191 acyl-activating enzyme (AAE) consensus motif; other site 1274814009192 putative AMP binding site [chemical binding]; other site 1274814009193 putative active site [active] 1274814009194 putative CoA binding site [chemical binding]; other site 1274814009195 O-succinylbenzoate synthase; Provisional; Region: PRK05105 1274814009196 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 1274814009197 active site 1274814009198 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1274814009199 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 1274814009200 substrate binding site [chemical binding]; other site 1274814009201 oxyanion hole (OAH) forming residues; other site 1274814009202 trimer interface [polypeptide binding]; other site 1274814009203 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 1274814009204 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 1274814009205 nucleophilic elbow; other site 1274814009206 catalytic triad; other site 1274814009207 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 1274814009208 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 1274814009209 dimer interface [polypeptide binding]; other site 1274814009210 tetramer interface [polypeptide binding]; other site 1274814009211 PYR/PP interface [polypeptide binding]; other site 1274814009212 TPP binding site [chemical binding]; other site 1274814009213 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 1274814009214 TPP-binding site; other site 1274814009215 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 1274814009216 isochorismate synthases; Region: isochor_syn; TIGR00543 1274814009217 hypothetical protein; Provisional; Region: PRK10404 1274814009218 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814009219 Coenzyme A binding pocket [chemical binding]; other site 1274814009220 ribonuclease BN; Region: true_RNase_BN; TIGR02649 1274814009221 potential frameshift: common BLAST hit: gi|260856316|ref|YP_003230207.1| deubiquitinase 1274814009222 von Willebrand factor; Region: vWF_A; pfam12450 1274814009223 Uncharacterized protein containing a von Willebrand factor type A (vWA) domain [General function prediction only]; Region: COG2304 1274814009224 VWA subgroup: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subgroup; cd01465 1274814009225 metal ion-dependent adhesion site (MIDAS); other site 1274814009226 Domain of unknown function (DUF3520); Region: DUF3520; pfam12034 1274814009227 M28 Zn-Peptidases; Region: M28_like_1; cd05640 1274814009228 Peptidase family M28; Region: Peptidase_M28; pfam04389 1274814009229 metal binding site [ion binding]; metal-binding site 1274814009230 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 1274814009231 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 1274814009232 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1274814009233 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 1274814009234 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1274814009235 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 1274814009236 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 1274814009237 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1274814009238 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 1274814009239 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 1274814009240 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 1274814009241 4Fe-4S binding domain; Region: Fer4; pfam00037 1274814009242 4Fe-4S binding domain; Region: Fer4; pfam00037 1274814009243 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 1274814009244 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 1274814009245 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1274814009246 catalytic loop [active] 1274814009247 iron binding site [ion binding]; other site 1274814009248 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 1274814009249 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 1274814009250 [4Fe-4S] binding site [ion binding]; other site 1274814009251 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 1274814009252 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 1274814009253 SLBB domain; Region: SLBB; pfam10531 1274814009254 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 1274814009255 NADH dehydrogenase subunit E; Validated; Region: PRK07539 1274814009256 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 1274814009257 putative dimer interface [polypeptide binding]; other site 1274814009258 [2Fe-2S] cluster binding site [ion binding]; other site 1274814009259 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 1274814009260 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 1274814009261 NADH dehydrogenase subunit D; Validated; Region: PRK06075 1274814009262 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 1274814009263 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 1274814009264 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 1274814009265 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814009266 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 1274814009267 putative dimerization interface [polypeptide binding]; other site 1274814009268 aminotransferase AlaT; Validated; Region: PRK09265 1274814009269 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1274814009270 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814009271 homodimer interface [polypeptide binding]; other site 1274814009272 catalytic residue [active] 1274814009273 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1274814009274 Zn2+ binding site [ion binding]; other site 1274814009275 Mg2+ binding site [ion binding]; other site 1274814009276 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1274814009277 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1274814009278 TrkA-C domain; Region: TrkA_C; pfam02080 1274814009279 TrkA-C domain; Region: TrkA_C; pfam02080 1274814009280 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 1274814009281 putative phosphatase; Provisional; Region: PRK11587 1274814009282 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 1274814009283 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814009284 motif II; other site 1274814009285 hypothetical protein; Validated; Region: PRK05445 1274814009286 hypothetical protein; Provisional; Region: PRK01816 1274814009287 propionate/acetate kinase; Provisional; Region: PRK12379 1274814009288 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 1274814009289 phosphate acetyltransferase; Reviewed; Region: PRK05632 1274814009290 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1274814009291 DRTGG domain; Region: DRTGG; pfam07085 1274814009292 phosphate acetyltransferase; Region: pta; TIGR00651 1274814009293 hypothetical protein; Provisional; Region: PRK11588 1274814009294 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1274814009295 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 1274814009296 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 1274814009297 nudix motif; other site 1274814009298 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 1274814009299 active site 1274814009300 metal binding site [ion binding]; metal-binding site 1274814009301 homotetramer interface [polypeptide binding]; other site 1274814009302 glutathione S-transferase; Provisional; Region: PRK15113 1274814009303 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 1274814009304 C-terminal domain interface [polypeptide binding]; other site 1274814009305 GSH binding site (G-site) [chemical binding]; other site 1274814009306 dimer interface [polypeptide binding]; other site 1274814009307 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 1274814009308 N-terminal domain interface [polypeptide binding]; other site 1274814009309 putative dimer interface [polypeptide binding]; other site 1274814009310 putative substrate binding pocket (H-site) [chemical binding]; other site 1274814009311 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 1274814009312 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1274814009313 C-terminal domain interface [polypeptide binding]; other site 1274814009314 GSH binding site (G-site) [chemical binding]; other site 1274814009315 dimer interface [polypeptide binding]; other site 1274814009316 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 1274814009317 N-terminal domain interface [polypeptide binding]; other site 1274814009318 putative dimer interface [polypeptide binding]; other site 1274814009319 active site 1274814009320 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1274814009321 homooctamer interface [polypeptide binding]; other site 1274814009322 active site 1274814009323 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 1274814009324 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 1274814009325 putative NAD(P) binding site [chemical binding]; other site 1274814009326 putative active site [active] 1274814009327 putative transposase; Provisional; Region: PRK09857 1274814009328 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1274814009329 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 1274814009330 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1274814009331 Walker A/P-loop; other site 1274814009332 ATP binding site [chemical binding]; other site 1274814009333 Q-loop/lid; other site 1274814009334 ABC transporter signature motif; other site 1274814009335 Walker B; other site 1274814009336 D-loop; other site 1274814009337 H-loop/switch region; other site 1274814009338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814009339 dimer interface [polypeptide binding]; other site 1274814009340 conserved gate region; other site 1274814009341 putative PBP binding loops; other site 1274814009342 ABC-ATPase subunit interface; other site 1274814009343 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1274814009344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814009345 dimer interface [polypeptide binding]; other site 1274814009346 conserved gate region; other site 1274814009347 putative PBP binding loops; other site 1274814009348 ABC-ATPase subunit interface; other site 1274814009349 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 1274814009350 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814009351 substrate binding pocket [chemical binding]; other site 1274814009352 membrane-bound complex binding site; other site 1274814009353 hinge residues; other site 1274814009354 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 1274814009355 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814009356 substrate binding pocket [chemical binding]; other site 1274814009357 membrane-bound complex binding site; other site 1274814009358 hinge residues; other site 1274814009359 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 1274814009360 Flavoprotein; Region: Flavoprotein; pfam02441 1274814009361 amidophosphoribosyltransferase; Provisional; Region: PRK09246 1274814009362 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 1274814009363 active site 1274814009364 tetramer interface [polypeptide binding]; other site 1274814009365 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1274814009366 active site 1274814009367 colicin V production protein; Provisional; Region: PRK10845 1274814009368 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 1274814009369 cell division protein DedD; Provisional; Region: PRK11633 1274814009370 Sporulation related domain; Region: SPOR; pfam05036 1274814009371 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 1274814009372 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 1274814009373 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 1274814009374 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 1274814009375 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 1274814009376 hypothetical protein; Provisional; Region: PRK10847 1274814009377 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1274814009378 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 1274814009379 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 1274814009380 dimerization interface 3.5A [polypeptide binding]; other site 1274814009381 active site 1274814009382 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 1274814009383 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1274814009384 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 1274814009385 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 1274814009386 ligand binding site [chemical binding]; other site 1274814009387 NAD binding site [chemical binding]; other site 1274814009388 catalytic site [active] 1274814009389 homodimer interface [polypeptide binding]; other site 1274814009390 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 1274814009391 putative transporter; Provisional; Region: PRK12382 1274814009392 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814009393 putative substrate translocation pore; other site 1274814009394 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 1274814009395 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 1274814009396 dimer interface [polypeptide binding]; other site 1274814009397 active site 1274814009398 Uncharacterized conserved protein [Function unknown]; Region: COG4121 1274814009399 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 1274814009400 YfcL protein; Region: YfcL; pfam08891 1274814009401 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 1274814009402 hypothetical protein; Provisional; Region: PRK10621 1274814009403 Predicted permeases [General function prediction only]; Region: COG0730 1274814009404 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 1274814009405 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 1274814009406 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 1274814009407 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 1274814009408 Tetramer interface [polypeptide binding]; other site 1274814009409 active site 1274814009410 FMN-binding site [chemical binding]; other site 1274814009411 HemK family putative methylases; Region: hemK_fam; TIGR00536 1274814009412 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814009413 S-adenosylmethionine binding site [chemical binding]; other site 1274814009414 hypothetical protein; Provisional; Region: PRK04946 1274814009415 Smr domain; Region: Smr; pfam01713 1274814009416 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 1274814009417 Fimbrial protein; Region: Fimbrial; cl01416 1274814009418 Fimbrial protein; Region: Fimbrial; cl01416 1274814009419 Fimbrial protein; Region: Fimbrial; cl01416 1274814009420 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1274814009421 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1274814009422 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 1274814009423 PapC N-terminal domain; Region: PapC_N; pfam13954 1274814009424 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1274814009425 PapC C-terminal domain; Region: PapC_C; pfam13953 1274814009426 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1274814009427 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 1274814009428 catalytic core [active] 1274814009429 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 1274814009430 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1274814009431 substrate binding site [chemical binding]; other site 1274814009432 oxyanion hole (OAH) forming residues; other site 1274814009433 trimer interface [polypeptide binding]; other site 1274814009434 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1274814009435 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1274814009436 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 1274814009437 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1274814009438 dimer interface [polypeptide binding]; other site 1274814009439 active site 1274814009440 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 1274814009441 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 1274814009442 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 1274814009443 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 1274814009444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814009445 putative substrate translocation pore; other site 1274814009446 oligosaccharide:H+ symporter; Region: 2A0105; TIGR00882 1274814009447 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1274814009448 Fructokinases (FRKs) mainly from bacteria and plants are enzymes with high specificity for fructose, as are all FRKs, but they catalyzes the conversion of fructose to fructose-6-phosphate, which is an entry point into glycolysis via conversion into...; Region: bac_FRK; cd01167 1274814009449 putative substrate binding site [chemical binding]; other site 1274814009450 putative ATP binding site [chemical binding]; other site 1274814009451 Beta-fructosidases (levanase/invertase) [Carbohydrate transport and metabolism]; Region: SacC; COG1621 1274814009452 Glycosyl hydrolase family 32, beta-fructosidases; Region: GH32_B_Fructosidase; cd08996 1274814009453 substrate binding [chemical binding]; other site 1274814009454 active site 1274814009455 Glycosyl hydrolases family 32 C terminal; Region: Glyco_hydro_32C; pfam08244 1274814009456 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814009457 DNA binding site [nucleotide binding] 1274814009458 domain linker motif; other site 1274814009459 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 1274814009460 Ligand-binding domain of DNA-binding regulatory proteins specific to sucrose that are members of the LacI-GalR family of bacterial transcription repressors; Region: PBP1_sucrose_transcription_regulator; cd06288 1274814009461 putative dimerization interface [polypeptide binding]; other site 1274814009462 putative ligand binding site [chemical binding]; other site 1274814009463 fructuronate transporter; Provisional; Region: PRK10034; cl15264 1274814009464 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 1274814009465 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 1274814009466 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1274814009467 catalytic residue [active] 1274814009468 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1274814009469 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814009470 putative substrate translocation pore; other site 1274814009471 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814009472 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 1274814009473 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1274814009474 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814009475 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 1274814009476 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814009477 active site 1274814009478 phosphorylation site [posttranslational modification] 1274814009479 intermolecular recognition site; other site 1274814009480 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814009481 DNA binding residues [nucleotide binding] 1274814009482 dimerization interface [polypeptide binding]; other site 1274814009483 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 1274814009484 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814009485 substrate binding pocket [chemical binding]; other site 1274814009486 membrane-bound complex binding site; other site 1274814009487 hinge residues; other site 1274814009488 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814009489 substrate binding pocket [chemical binding]; other site 1274814009490 membrane-bound complex binding site; other site 1274814009491 hinge residues; other site 1274814009492 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814009493 dimer interface [polypeptide binding]; other site 1274814009494 phosphorylation site [posttranslational modification] 1274814009495 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814009496 ATP binding site [chemical binding]; other site 1274814009497 Mg2+ binding site [ion binding]; other site 1274814009498 G-X-G motif; other site 1274814009499 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814009500 active site 1274814009501 phosphorylation site [posttranslational modification] 1274814009502 intermolecular recognition site; other site 1274814009503 dimerization interface [polypeptide binding]; other site 1274814009504 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1274814009505 putative binding surface; other site 1274814009506 active site 1274814009507 putative CoA-transferase; Provisional; Region: PRK11430 1274814009508 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1274814009509 putative transporter YfdV; Provisional; Region: PRK09903 1274814009510 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 1274814009511 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1274814009512 PYR/PP interface [polypeptide binding]; other site 1274814009513 dimer interface [polypeptide binding]; other site 1274814009514 TPP binding site [chemical binding]; other site 1274814009515 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1274814009516 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 1274814009517 TPP-binding site; other site 1274814009518 dimer interface [polypeptide binding]; other site 1274814009519 formyl-coenzyme A transferase; Provisional; Region: PRK05398 1274814009520 CoA-transferase family III; Region: CoA_transf_3; pfam02515 1274814009521 hypothetical protein; Provisional; Region: PRK10316 1274814009522 YfdX protein; Region: YfdX; pfam10938 1274814009523 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 1274814009524 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 1274814009525 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 1274814009526 putative acyl-acceptor binding pocket; other site 1274814009527 aminotransferase; Validated; Region: PRK08175 1274814009528 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1274814009529 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814009530 homodimer interface [polypeptide binding]; other site 1274814009531 catalytic residue [active] 1274814009532 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 1274814009533 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 1274814009534 GAF domain; Region: GAF; pfam01590 1274814009535 Histidine kinase; Region: His_kinase; pfam06580 1274814009536 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814009537 ATP binding site [chemical binding]; other site 1274814009538 Mg2+ binding site [ion binding]; other site 1274814009539 G-X-G motif; other site 1274814009540 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 1274814009541 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814009542 active site 1274814009543 phosphorylation site [posttranslational modification] 1274814009544 intermolecular recognition site; other site 1274814009545 dimerization interface [polypeptide binding]; other site 1274814009546 LytTr DNA-binding domain; Region: LytTR; pfam04397 1274814009547 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1274814009548 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814009549 potential frameshift: common BLAST hit: gi|384544026|ref|YP_005728089.1| putative Phosphoenolpyruvate-protein kinase (PTS system EI 1274814009550 exoaminopeptidase; Provisional; Region: PRK09961 1274814009551 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 1274814009552 oligomer interface [polypeptide binding]; other site 1274814009553 active site 1274814009554 metal binding site [ion binding]; metal-binding site 1274814009555 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1274814009556 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 1274814009557 active site 1274814009558 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 1274814009559 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 1274814009560 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 1274814009561 active site 1274814009562 P-loop; other site 1274814009563 phosphorylation site [posttranslational modification] 1274814009564 glucokinase, proteobacterial type; Region: glk; TIGR00749 1274814009565 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1274814009566 nucleotide binding site [chemical binding]; other site 1274814009567 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 1274814009568 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 1274814009569 Cl- selectivity filter; other site 1274814009570 Cl- binding residues [ion binding]; other site 1274814009571 pore gating glutamate residue; other site 1274814009572 dimer interface [polypeptide binding]; other site 1274814009573 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 1274814009574 manganese transport protein MntH; Reviewed; Region: PRK00701 1274814009575 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 1274814009576 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 1274814009577 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 1274814009578 Nucleoside recognition; Region: Gate; pfam07670 1274814009579 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 1274814009580 MASE1; Region: MASE1; pfam05231 1274814009581 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1274814009582 diguanylate cyclase; Region: GGDEF; smart00267 1274814009583 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814009584 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 1274814009585 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814009586 salt bridge; other site 1274814009587 non-specific DNA binding site [nucleotide binding]; other site 1274814009588 sequence-specific DNA binding site [nucleotide binding]; other site 1274814009589 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 1274814009590 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1274814009591 active site 1274814009592 HIGH motif; other site 1274814009593 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 1274814009594 active site 1274814009595 KMSKS motif; other site 1274814009596 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 1274814009597 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814009598 The C-terminal substrate binding domain of LysR-type transcriptional regulator XapR involved in xanthosine catabolism, contains the type 2 periplasmic binding fold; Region: PBP2_XapR; cd08449 1274814009599 putative dimerization interface [polypeptide binding]; other site 1274814009600 putative substrate binding pocket [chemical binding]; other site 1274814009601 XapX domain; Region: XapX; TIGR03510 1274814009602 nucleoside transporter; Region: 2A0110; TIGR00889 1274814009603 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814009604 putative substrate translocation pore; other site 1274814009605 purine nucleoside phosphorylase; Provisional; Region: PRK08202 1274814009606 hypothetical protein; Provisional; Region: PRK11528 1274814009607 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1274814009608 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814009609 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 1274814009610 putative dimerization interface [polypeptide binding]; other site 1274814009611 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 1274814009612 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 1274814009613 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 1274814009614 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 1274814009615 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 1274814009616 nucleotide binding pocket [chemical binding]; other site 1274814009617 K-X-D-G motif; other site 1274814009618 catalytic site [active] 1274814009619 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1274814009620 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 1274814009621 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 1274814009622 Dimer interface [polypeptide binding]; other site 1274814009623 BRCT sequence motif; other site 1274814009624 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 1274814009625 cell division protein ZipA; Provisional; Region: PRK03427 1274814009626 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 1274814009627 FtsZ protein binding site [polypeptide binding]; other site 1274814009628 putative sulfate transport protein CysZ; Validated; Region: PRK04949 1274814009629 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 1274814009630 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1274814009631 dimer interface [polypeptide binding]; other site 1274814009632 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814009633 catalytic residue [active] 1274814009634 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1274814009635 dimerization domain swap beta strand [polypeptide binding]; other site 1274814009636 regulatory protein interface [polypeptide binding]; other site 1274814009637 active site 1274814009638 regulatory phosphorylation site [posttranslational modification]; other site 1274814009639 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 1274814009640 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1274814009641 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1274814009642 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1274814009643 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1274814009644 HPr interaction site; other site 1274814009645 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1274814009646 active site 1274814009647 phosphorylation site [posttranslational modification] 1274814009648 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 1274814009649 dimer interface [polypeptide binding]; other site 1274814009650 pyridoxamine kinase; Validated; Region: PRK05756 1274814009651 pyridoxal binding site [chemical binding]; other site 1274814009652 ATP binding site [chemical binding]; other site 1274814009653 hypothetical protein; Provisional; Region: PRK10318 1274814009654 cysteine synthase B; Region: cysM; TIGR01138 1274814009655 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 1274814009656 dimer interface [polypeptide binding]; other site 1274814009657 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814009658 catalytic residue [active] 1274814009659 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 1274814009660 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 1274814009661 Walker A/P-loop; other site 1274814009662 ATP binding site [chemical binding]; other site 1274814009663 Q-loop/lid; other site 1274814009664 ABC transporter signature motif; other site 1274814009665 Walker B; other site 1274814009666 D-loop; other site 1274814009667 H-loop/switch region; other site 1274814009668 TOBE-like domain; Region: TOBE_3; pfam12857 1274814009669 sulfate transport protein; Provisional; Region: cysT; CHL00187 1274814009670 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814009671 dimer interface [polypeptide binding]; other site 1274814009672 conserved gate region; other site 1274814009673 putative PBP binding loops; other site 1274814009674 ABC-ATPase subunit interface; other site 1274814009675 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 1274814009676 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814009677 dimer interface [polypeptide binding]; other site 1274814009678 conserved gate region; other site 1274814009679 putative PBP binding loops; other site 1274814009680 ABC-ATPase subunit interface; other site 1274814009681 thiosulfate transporter subunit; Provisional; Region: PRK10852 1274814009682 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 1274814009683 short chain dehydrogenase; Provisional; Region: PRK08226 1274814009684 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 1274814009685 NAD binding site [chemical binding]; other site 1274814009686 homotetramer interface [polypeptide binding]; other site 1274814009687 homodimer interface [polypeptide binding]; other site 1274814009688 active site 1274814009689 transcriptional regulator MurR; Provisional; Region: PRK15482 1274814009690 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1274814009691 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1274814009692 putative active site [active] 1274814009693 N-acetylmuramic acid 6-phosphate etherase; Region: TIGR00274 1274814009694 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 1274814009695 putative active site [active] 1274814009696 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 1274814009697 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1274814009698 active site turn [active] 1274814009699 phosphorylation site [posttranslational modification] 1274814009700 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1274814009701 putative periplasmic esterase; Provisional; Region: PRK03642 1274814009702 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 1274814009703 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 1274814009704 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 1274814009705 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 1274814009706 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 1274814009707 putative acetyltransferase; Provisional; Region: PRK03624 1274814009708 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814009709 Coenzyme A binding pocket [chemical binding]; other site 1274814009710 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 1274814009711 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1274814009712 active site 1274814009713 metal binding site [ion binding]; metal-binding site 1274814009714 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 1274814009715 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 1274814009716 transcriptional regulator EutR; Provisional; Region: PRK10130 1274814009717 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814009718 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814009719 carboxysome structural protein EutK; Provisional; Region: PRK15466 1274814009720 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 1274814009721 Hexamer interface [polypeptide binding]; other site 1274814009722 Hexagonal pore residue; other site 1274814009723 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 1274814009724 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 1274814009725 putative hexamer interface [polypeptide binding]; other site 1274814009726 putative hexagonal pore; other site 1274814009727 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 1274814009728 putative hexamer interface [polypeptide binding]; other site 1274814009729 putative hexagonal pore; other site 1274814009730 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 1274814009731 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 1274814009732 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 1274814009733 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1274814009734 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 1274814009735 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 1274814009736 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 1274814009737 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 1274814009738 active site 1274814009739 metal binding site [ion binding]; metal-binding site 1274814009740 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 1274814009741 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1274814009742 nucleotide binding site [chemical binding]; other site 1274814009743 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 1274814009744 putative catalytic cysteine [active] 1274814009745 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 1274814009746 Hexamer/Pentamer interface [polypeptide binding]; other site 1274814009747 central pore; other site 1274814009748 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 1274814009749 1,2-propanediol utilization protein A (PduA), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduA; cd07059 1274814009750 Hexamer interface [polypeptide binding]; other site 1274814009751 Putative hexagonal pore residue; other site 1274814009752 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1274814009753 Phosphate acetyl/butaryl transferase; Region: PTA_PTB; cl17212 1274814009754 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 1274814009755 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 1274814009756 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 1274814009757 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 1274814009758 G1 box; other site 1274814009759 GTP/Mg2+ binding site [chemical binding]; other site 1274814009760 G2 box; other site 1274814009761 Switch I region; other site 1274814009762 G3 box; other site 1274814009763 Switch II region; other site 1274814009764 G4 box; other site 1274814009765 G5 box; other site 1274814009766 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 1274814009767 putative hexamer interface [polypeptide binding]; other site 1274814009768 putative hexagonal pore; other site 1274814009769 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 1274814009770 Malic enzyme, N-terminal domain; Region: malic; pfam00390 1274814009771 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 1274814009772 putative NAD(P) binding site [chemical binding]; other site 1274814009773 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 1274814009774 transaldolase-like protein; Provisional; Region: PTZ00411 1274814009775 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 1274814009776 active site 1274814009777 dimer interface [polypeptide binding]; other site 1274814009778 catalytic residue [active] 1274814009779 transketolase; Reviewed; Region: PRK12753 1274814009780 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1274814009781 TPP-binding site [chemical binding]; other site 1274814009782 dimer interface [polypeptide binding]; other site 1274814009783 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1274814009784 PYR/PP interface [polypeptide binding]; other site 1274814009785 dimer interface [polypeptide binding]; other site 1274814009786 TPP binding site [chemical binding]; other site 1274814009787 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1274814009788 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 1274814009789 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 1274814009790 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1274814009791 dimer interface [polypeptide binding]; other site 1274814009792 ADP-ribose binding site [chemical binding]; other site 1274814009793 active site 1274814009794 nudix motif; other site 1274814009795 metal binding site [ion binding]; metal-binding site 1274814009796 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 1274814009797 4Fe-4S binding domain; Region: Fer4; pfam00037 1274814009798 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1274814009799 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1274814009800 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 1274814009801 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 1274814009802 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1274814009803 dimerization interface [polypeptide binding]; other site 1274814009804 Histidine kinase; Region: HisKA_3; pfam07730 1274814009805 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814009806 ATP binding site [chemical binding]; other site 1274814009807 Mg2+ binding site [ion binding]; other site 1274814009808 G-X-G motif; other site 1274814009809 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 1274814009810 Protein export membrane protein; Region: SecD_SecF; cl14618 1274814009811 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 1274814009812 ArsC family; Region: ArsC; pfam03960 1274814009813 putative catalytic residues [active] 1274814009814 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 1274814009815 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 1274814009816 metal binding site [ion binding]; metal-binding site 1274814009817 dimer interface [polypeptide binding]; other site 1274814009818 hypothetical protein; Provisional; Region: PRK13664 1274814009819 putative hydrolase; Provisional; Region: PRK11460 1274814009820 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 1274814009821 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 1274814009822 Helicase; Region: Helicase_RecD; pfam05127 1274814009823 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 1274814009824 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 1274814009825 Predicted metalloprotease [General function prediction only]; Region: COG2321 1274814009826 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 1274814009827 PIN domain of ribonucleases (toxins), VapC and FitB, of prokaryotic toxin/antitoxin operons, Pyrococcus horikoshii protein PH0500, and other similar bacterial and archaeal homologs; Region: PIN_VapC-FitB; cd09881 1274814009828 oligomeric interface; other site 1274814009829 putative active site [active] 1274814009830 homodimer interface [polypeptide binding]; other site 1274814009831 Virulence-associated protein and related proteins [Function unknown]; Region: VagC; COG4456 1274814009832 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 1274814009833 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 1274814009834 ATP binding site [chemical binding]; other site 1274814009835 active site 1274814009836 substrate binding site [chemical binding]; other site 1274814009837 Zinc peptidases M18, M20, M28, and M42; Region: Zinc_peptidase_like; cl14876 1274814009838 lipoprotein; Provisional; Region: PRK11679 1274814009839 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 1274814009840 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 1274814009841 dihydrodipicolinate synthase; Region: dapA; TIGR00674 1274814009842 dimer interface [polypeptide binding]; other site 1274814009843 active site 1274814009844 catalytic residue [active] 1274814009845 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 1274814009846 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 1274814009847 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 1274814009848 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 1274814009849 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 1274814009850 catalytic triad [active] 1274814009851 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1274814009852 4Fe-4S binding domain; Region: Fer4; pfam00037 1274814009853 hydrogenase 4 subunit B; Validated; Region: PRK06521 1274814009854 hydrogenase 4 subunit B; Validated; Region: PRK06521 1274814009855 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1274814009856 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1274814009857 NADH dehydrogenase; Region: NADHdh; cl00469 1274814009858 hydrogenase 4 subunit D; Validated; Region: PRK06525 1274814009859 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1274814009860 hydrogenase 4 subunit D; Validated; Region: PRK06525 1274814009861 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 1274814009862 hydrogenase 4 subunit F; Validated; Region: PRK06458 1274814009863 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1274814009864 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1274814009865 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1274814009866 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1274814009867 hydrogenase 4 subunit H; Validated; Region: PRK08222 1274814009868 4Fe-4S binding domain; Region: Fer4; pfam00037 1274814009869 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1274814009870 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1274814009871 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 1274814009872 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1274814009873 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814009874 Walker A motif; other site 1274814009875 ATP binding site [chemical binding]; other site 1274814009876 Walker B motif; other site 1274814009877 arginine finger; other site 1274814009878 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1274814009879 putative formate transporter; Provisional; Region: focB; PRK09713 1274814009880 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 1274814009881 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1274814009882 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 1274814009883 Peptidase family M48; Region: Peptidase_M48; cl12018 1274814009884 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1274814009885 ArsC family; Region: ArsC; pfam03960 1274814009886 catalytic residues [active] 1274814009887 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 1274814009888 DNA replication initiation factor; Provisional; Region: PRK08084 1274814009889 uracil transporter; Provisional; Region: PRK10720 1274814009890 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1274814009891 active site 1274814009892 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 1274814009893 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 1274814009894 dimerization interface [polypeptide binding]; other site 1274814009895 putative ATP binding site [chemical binding]; other site 1274814009896 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 1274814009897 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 1274814009898 active site 1274814009899 substrate binding site [chemical binding]; other site 1274814009900 cosubstrate binding site; other site 1274814009901 catalytic site [active] 1274814009902 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 1274814009903 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 1274814009904 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 1274814009905 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 1274814009906 domain interface [polypeptide binding]; other site 1274814009907 active site 1274814009908 catalytic site [active] 1274814009909 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 1274814009910 putative active site [active] 1274814009911 catalytic site [active] 1274814009912 exopolyphosphatase; Provisional; Region: PRK10854 1274814009913 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1274814009914 MASE1; Region: MASE1; pfam05231 1274814009915 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 1274814009916 diguanylate cyclase; Region: GGDEF; smart00267 1274814009917 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814009918 Protein of unknown function (DUF2633); Region: DUF2633; pfam11119 1274814009919 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 1274814009920 GMP synthase; Reviewed; Region: guaA; PRK00074 1274814009921 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 1274814009922 AMP/PPi binding site [chemical binding]; other site 1274814009923 candidate oxyanion hole; other site 1274814009924 catalytic triad [active] 1274814009925 potential glutamine specificity residues [chemical binding]; other site 1274814009926 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 1274814009927 ATP Binding subdomain [chemical binding]; other site 1274814009928 Ligand Binding sites [chemical binding]; other site 1274814009929 Dimerization subdomain; other site 1274814009930 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 1274814009931 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1274814009932 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 1274814009933 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 1274814009934 active site 1274814009935 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 1274814009936 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 1274814009937 generic binding surface II; other site 1274814009938 generic binding surface I; other site 1274814009939 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 1274814009940 GTP-binding protein Der; Reviewed; Region: PRK00093 1274814009941 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 1274814009942 G1 box; other site 1274814009943 GTP/Mg2+ binding site [chemical binding]; other site 1274814009944 Switch I region; other site 1274814009945 G2 box; other site 1274814009946 Switch II region; other site 1274814009947 G3 box; other site 1274814009948 G4 box; other site 1274814009949 G5 box; other site 1274814009950 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 1274814009951 G1 box; other site 1274814009952 GTP/Mg2+ binding site [chemical binding]; other site 1274814009953 Switch I region; other site 1274814009954 G2 box; other site 1274814009955 G3 box; other site 1274814009956 Switch II region; other site 1274814009957 G4 box; other site 1274814009958 G5 box; other site 1274814009959 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 1274814009960 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 1274814009961 Trp docking motif [polypeptide binding]; other site 1274814009962 active site 1274814009963 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 1274814009964 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 1274814009965 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 1274814009966 dimer interface [polypeptide binding]; other site 1274814009967 motif 1; other site 1274814009968 active site 1274814009969 motif 2; other site 1274814009970 motif 3; other site 1274814009971 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 1274814009972 anticodon binding site; other site 1274814009973 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 1274814009974 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1274814009975 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 1274814009976 cytoskeletal protein RodZ; Provisional; Region: PRK10856 1274814009977 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814009978 non-specific DNA binding site [nucleotide binding]; other site 1274814009979 salt bridge; other site 1274814009980 sequence-specific DNA binding site [nucleotide binding]; other site 1274814009981 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 1274814009982 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 1274814009983 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814009984 FeS/SAM binding site; other site 1274814009985 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 1274814009986 active site 1274814009987 multimer interface [polypeptide binding]; other site 1274814009988 penicillin-binding protein 1C; Provisional; Region: PRK11240 1274814009989 Transglycosylase; Region: Transgly; pfam00912 1274814009990 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1274814009991 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 1274814009992 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 1274814009993 MG2 domain; Region: A2M_N; pfam01835 1274814009994 Alpha-2-macroglobulin family; Region: A2M; pfam00207 1274814009995 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 1274814009996 surface patch; other site 1274814009997 thioester region; other site 1274814009998 specificity defining residues; other site 1274814009999 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 1274814010000 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 1274814010001 active site residue [active] 1274814010002 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 1274814010003 active site residue [active] 1274814010004 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 1274814010005 aminopeptidase B; Provisional; Region: PRK05015 1274814010006 Peptidase; Region: DUF3663; pfam12404 1274814010007 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 1274814010008 interface (dimer of trimers) [polypeptide binding]; other site 1274814010009 Substrate-binding/catalytic site; other site 1274814010010 Zn-binding sites [ion binding]; other site 1274814010011 hypothetical protein; Provisional; Region: PRK10721 1274814010012 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 1274814010013 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1274814010014 catalytic loop [active] 1274814010015 iron binding site [ion binding]; other site 1274814010016 chaperone protein HscA; Provisional; Region: hscA; PRK05183 1274814010017 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 1274814010018 nucleotide binding site [chemical binding]; other site 1274814010019 putative NEF/HSP70 interaction site [polypeptide binding]; other site 1274814010020 SBD interface [polypeptide binding]; other site 1274814010021 co-chaperone HscB; Provisional; Region: hscB; PRK05014 1274814010022 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 1274814010023 HSP70 interaction site [polypeptide binding]; other site 1274814010024 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 1274814010025 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 1274814010026 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 1274814010027 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 1274814010028 trimerization site [polypeptide binding]; other site 1274814010029 active site 1274814010030 cysteine desulfurase; Provisional; Region: PRK14012 1274814010031 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 1274814010032 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1274814010033 catalytic residue [active] 1274814010034 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 1274814010035 Rrf2 family protein; Region: rrf2_super; TIGR00738 1274814010036 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 1274814010037 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 1274814010038 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 1274814010039 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 1274814010040 active site 1274814010041 dimerization interface [polypeptide binding]; other site 1274814010042 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 1274814010043 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1274814010044 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 1274814010045 PRD domain; Region: PRD; pfam00874 1274814010046 PRD domain; Region: PRD; pfam00874 1274814010047 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 1274814010048 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814010049 putative substrate translocation pore; other site 1274814010050 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 1274814010051 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814010052 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1274814010053 dimerization interface [polypeptide binding]; other site 1274814010054 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 1274814010055 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 1274814010056 iron-sulfur cluster [ion binding]; other site 1274814010057 [2Fe-2S] cluster binding site [ion binding]; other site 1274814010058 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 1274814010059 beta subunit interface [polypeptide binding]; other site 1274814010060 alpha subunit interface [polypeptide binding]; other site 1274814010061 active site 1274814010062 substrate binding site [chemical binding]; other site 1274814010063 Fe binding site [ion binding]; other site 1274814010064 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 1274814010065 inter-subunit interface; other site 1274814010066 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 1274814010067 [2Fe-2S] cluster binding site [ion binding]; other site 1274814010068 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 1274814010069 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 1274814010070 NAD binding site [chemical binding]; other site 1274814010071 active site 1274814010072 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 1274814010073 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1274814010074 Predicted membrane protein [Function unknown]; Region: COG2259 1274814010075 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 1274814010076 active site 1274814010077 catalytic residues [active] 1274814010078 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1274814010079 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 1274814010080 putative NAD(P) binding site [chemical binding]; other site 1274814010081 catalytic Zn binding site [ion binding]; other site 1274814010082 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1274814010083 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1274814010084 TM-ABC transporter signature motif; other site 1274814010085 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 1274814010086 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1274814010087 Walker A/P-loop; other site 1274814010088 ATP binding site [chemical binding]; other site 1274814010089 Q-loop/lid; other site 1274814010090 ABC transporter signature motif; other site 1274814010091 Walker B; other site 1274814010092 D-loop; other site 1274814010093 H-loop/switch region; other site 1274814010094 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1274814010095 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 1274814010096 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 1274814010097 ligand binding site [chemical binding]; other site 1274814010098 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1274814010099 TPR motif; other site 1274814010100 Tetratricopeptide repeat; Region: TPR_16; pfam13432 1274814010101 binding surface 1274814010102 TPR repeat; Region: TPR_11; pfam13414 1274814010103 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1274814010104 TPR motif; other site 1274814010105 binding surface 1274814010106 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 1274814010107 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 1274814010108 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1274814010109 nucleotide binding site [chemical binding]; other site 1274814010110 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 1274814010111 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 1274814010112 dimer interface [polypeptide binding]; other site 1274814010113 active site 1274814010114 glycine-pyridoxal phosphate binding site [chemical binding]; other site 1274814010115 folate binding site [chemical binding]; other site 1274814010116 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 1274814010117 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 1274814010118 heme-binding site [chemical binding]; other site 1274814010119 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 1274814010120 FAD binding pocket [chemical binding]; other site 1274814010121 FAD binding motif [chemical binding]; other site 1274814010122 phosphate binding motif [ion binding]; other site 1274814010123 beta-alpha-beta structure motif; other site 1274814010124 NAD binding pocket [chemical binding]; other site 1274814010125 Heme binding pocket [chemical binding]; other site 1274814010126 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 1274814010127 Nitrogen regulatory protein P-II; Region: P-II; smart00938 1274814010128 response regulator GlrR; Provisional; Region: PRK15115 1274814010129 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814010130 active site 1274814010131 phosphorylation site [posttranslational modification] 1274814010132 intermolecular recognition site; other site 1274814010133 dimerization interface [polypeptide binding]; other site 1274814010134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814010135 Walker A motif; other site 1274814010136 ATP binding site [chemical binding]; other site 1274814010137 Walker B motif; other site 1274814010138 arginine finger; other site 1274814010139 hypothetical protein; Provisional; Region: PRK10722 1274814010140 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 1274814010141 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814010142 dimer interface [polypeptide binding]; other site 1274814010143 phosphorylation site [posttranslational modification] 1274814010144 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814010145 ATP binding site [chemical binding]; other site 1274814010146 Mg2+ binding site [ion binding]; other site 1274814010147 G-X-G motif; other site 1274814010148 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 1274814010149 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 1274814010150 dimerization interface [polypeptide binding]; other site 1274814010151 ATP binding site [chemical binding]; other site 1274814010152 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 1274814010153 dimerization interface [polypeptide binding]; other site 1274814010154 ATP binding site [chemical binding]; other site 1274814010155 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 1274814010156 putative active site [active] 1274814010157 catalytic triad [active] 1274814010158 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 1274814010159 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814010160 substrate binding pocket [chemical binding]; other site 1274814010161 membrane-bound complex binding site; other site 1274814010162 hinge residues; other site 1274814010163 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1274814010164 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1274814010165 catalytic residue [active] 1274814010166 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 1274814010167 nucleoside/Zn binding site; other site 1274814010168 dimer interface [polypeptide binding]; other site 1274814010169 catalytic motif [active] 1274814010170 hypothetical protein; Provisional; Region: PRK11590 1274814010171 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 1274814010172 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 1274814010173 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 1274814010174 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 1274814010175 putative active site [active] 1274814010176 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 1274814010177 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 1274814010178 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 1274814010179 active site 1274814010180 hydrophilic channel; other site 1274814010181 dimerization interface [polypeptide binding]; other site 1274814010182 catalytic residues [active] 1274814010183 active site lid [active] 1274814010184 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 1274814010185 Recombination protein O N terminal; Region: RecO_N; pfam11967 1274814010186 Recombination protein O C terminal; Region: RecO_C; pfam02565 1274814010187 GTPase Era; Reviewed; Region: era; PRK00089 1274814010188 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 1274814010189 G1 box; other site 1274814010190 GTP/Mg2+ binding site [chemical binding]; other site 1274814010191 Switch I region; other site 1274814010192 G2 box; other site 1274814010193 Switch II region; other site 1274814010194 G3 box; other site 1274814010195 G4 box; other site 1274814010196 G5 box; other site 1274814010197 KH domain; Region: KH_2; pfam07650 1274814010198 ribonuclease III; Reviewed; Region: rnc; PRK00102 1274814010199 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 1274814010200 dimerization interface [polypeptide binding]; other site 1274814010201 active site 1274814010202 metal binding site [ion binding]; metal-binding site 1274814010203 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 1274814010204 dsRNA binding site [nucleotide binding]; other site 1274814010205 signal peptidase I; Provisional; Region: PRK10861 1274814010206 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1274814010207 Catalytic site [active] 1274814010208 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 1274814010209 GTP-binding protein LepA; Provisional; Region: PRK05433 1274814010210 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 1274814010211 G1 box; other site 1274814010212 putative GEF interaction site [polypeptide binding]; other site 1274814010213 GTP/Mg2+ binding site [chemical binding]; other site 1274814010214 Switch I region; other site 1274814010215 G2 box; other site 1274814010216 G3 box; other site 1274814010217 Switch II region; other site 1274814010218 G4 box; other site 1274814010219 G5 box; other site 1274814010220 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 1274814010221 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 1274814010222 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 1274814010223 SoxR reducing system protein RseC; Provisional; Region: PRK10862 1274814010224 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 1274814010225 anti-sigma E factor; Provisional; Region: rseB; PRK09455 1274814010226 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 1274814010227 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 1274814010228 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 1274814010229 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 1274814010230 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1274814010231 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1274814010232 DNA binding residues [nucleotide binding] 1274814010233 L-aspartate oxidase; Provisional; Region: PRK09077 1274814010234 L-aspartate oxidase; Provisional; Region: PRK06175 1274814010235 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 1274814010236 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 1274814010237 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1274814010238 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 1274814010239 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1274814010240 ATP binding site [chemical binding]; other site 1274814010241 Mg++ binding site [ion binding]; other site 1274814010242 motif III; other site 1274814010243 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1274814010244 nucleotide binding region [chemical binding]; other site 1274814010245 ATP-binding site [chemical binding]; other site 1274814010246 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814010247 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1274814010248 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814010249 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 1274814010250 dimerization interface [polypeptide binding]; other site 1274814010251 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 1274814010252 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 1274814010253 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 1274814010254 ligand binding site [chemical binding]; other site 1274814010255 active site 1274814010256 UGI interface [polypeptide binding]; other site 1274814010257 catalytic site [active] 1274814010258 putative methyltransferase; Provisional; Region: PRK10864 1274814010259 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 1274814010260 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1274814010261 thioredoxin 2; Provisional; Region: PRK10996 1274814010262 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 1274814010263 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1274814010264 catalytic residues [active] 1274814010265 Uncharacterized conserved protein [Function unknown]; Region: COG3148 1274814010266 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 1274814010267 CoA binding domain; Region: CoA_binding_2; pfam13380 1274814010268 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 1274814010269 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 1274814010270 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 1274814010271 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 1274814010272 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 1274814010273 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 1274814010274 domain interface [polypeptide binding]; other site 1274814010275 putative active site [active] 1274814010276 catalytic site [active] 1274814010277 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 1274814010278 domain interface [polypeptide binding]; other site 1274814010279 putative active site [active] 1274814010280 catalytic site [active] 1274814010281 lipoprotein; Provisional; Region: PRK10759 1274814010282 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 1274814010283 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814010284 putative substrate translocation pore; other site 1274814010285 protein disaggregation chaperone; Provisional; Region: PRK10865 1274814010286 Clp amino terminal domain; Region: Clp_N; pfam02861 1274814010287 Clp amino terminal domain; Region: Clp_N; pfam02861 1274814010288 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814010289 Walker A motif; other site 1274814010290 ATP binding site [chemical binding]; other site 1274814010291 Walker B motif; other site 1274814010292 arginine finger; other site 1274814010293 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814010294 Walker A motif; other site 1274814010295 ATP binding site [chemical binding]; other site 1274814010296 Walker B motif; other site 1274814010297 arginine finger; other site 1274814010298 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 1274814010299 hypothetical protein; Provisional; Region: PRK10723 1274814010300 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 1274814010301 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 1274814010302 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1274814010303 RNA binding surface [nucleotide binding]; other site 1274814010304 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 1274814010305 active site 1274814010306 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 1274814010307 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 1274814010308 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1274814010309 30S subunit binding site; other site 1274814010310 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 1274814010311 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 1274814010312 Prephenate dehydratase; Region: PDT; pfam00800 1274814010313 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 1274814010314 putative L-Phe binding site [chemical binding]; other site 1274814010315 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 1274814010316 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 1274814010317 prephenate dehydrogenase; Validated; Region: PRK08507 1274814010318 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 1274814010319 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 1274814010320 lipoprotein; Provisional; Region: PRK11443 1274814010321 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 1274814010322 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 1274814010323 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 1274814010324 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814010325 metal binding site [ion binding]; metal-binding site 1274814010326 active site 1274814010327 I-site; other site 1274814010328 putative outer membrane lipoprotein; Provisional; Region: PRK09967 1274814010329 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1274814010330 ligand binding site [chemical binding]; other site 1274814010331 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 1274814010332 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 1274814010333 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 1274814010334 RimM N-terminal domain; Region: RimM; pfam01782 1274814010335 PRC-barrel domain; Region: PRC; pfam05239 1274814010336 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 1274814010337 signal recognition particle protein; Provisional; Region: PRK10867 1274814010338 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 1274814010339 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1274814010340 P loop; other site 1274814010341 GTP binding site [chemical binding]; other site 1274814010342 Signal peptide binding domain; Region: SRP_SPB; pfam02978 1274814010343 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 1274814010344 hypothetical protein; Provisional; Region: PRK11573 1274814010345 Domain of unknown function DUF21; Region: DUF21; pfam01595 1274814010346 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 1274814010347 Transporter associated domain; Region: CorC_HlyC; smart01091 1274814010348 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 1274814010349 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 1274814010350 dimer interface [polypeptide binding]; other site 1274814010351 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 1274814010352 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 1274814010353 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 1274814010354 recombination and repair protein; Provisional; Region: PRK10869 1274814010355 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1274814010356 Walker A/P-loop; other site 1274814010357 ATP binding site [chemical binding]; other site 1274814010358 Q-loop/lid; other site 1274814010359 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 1274814010360 Q-loop/lid; other site 1274814010361 ABC transporter signature motif; other site 1274814010362 Walker B; other site 1274814010363 D-loop; other site 1274814010364 H-loop/switch region; other site 1274814010365 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 1274814010366 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 1274814010367 hypothetical protein; Validated; Region: PRK01777 1274814010368 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 1274814010369 putative coenzyme Q binding site [chemical binding]; other site 1274814010370 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 1274814010371 SmpB-tmRNA interface; other site 1274814010372 integrase; Provisional; Region: PRK09692 1274814010373 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 1274814010374 active site 1274814010375 Int/Topo IB signature motif; other site 1274814010376 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 1274814010377 Serine Recombinase family, catalytic domain; a DNA binding domain may be present either N- or C-terminal to the catalytic domain. These enzymes perform site-specific recombination of DNA molecules by a concerted, four-strand cleavage and rejoining...; Region: Ser_Recombinase; cd00338 1274814010378 catalytic residues [active] 1274814010379 catalytic nucleophile [active] 1274814010380 Recombinase; Region: Recombinase; pfam07508 1274814010381 ParB-like nuclease domain; Region: ParBc; pfam02195 1274814010382 RepB plasmid partitioning protein; Region: RepB; pfam07506 1274814010383 ParB-like nuclease domain; Region: ParB; smart00470 1274814010384 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 1274814010385 RepB plasmid partitioning protein; Region: RepB; pfam07506 1274814010386 HsdM N-terminal domain; Region: HsdM_N; pfam12161 1274814010387 N-6 DNA Methylase; Region: N6_Mtase; pfam02384 1274814010388 Methyltransferase domain; Region: Methyltransf_26; pfam13659 1274814010389 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 1274814010390 Restriction endonuclease S subunits [Defense mechanisms]; Region: HsdS; COG0732 1274814010391 Type I site-specific restriction-modification system, R (restriction) subunit and related helicases [Defense mechanisms]; Region: COG0610 1274814010392 Type I restriction enzyme R protein N terminus (HSDR_N); Region: HSDR_N; pfam04313 1274814010393 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1274814010394 ATP binding site [chemical binding]; other site 1274814010395 putative Mg++ binding site [ion binding]; other site 1274814010396 Domain of unknown function (DUF3387); Region: DUF3387; pfam11867 1274814010397 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 1274814010398 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 1274814010399 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 1274814010400 IS2 transposase TnpB; Reviewed; Region: PRK09409 1274814010401 HTH-like domain; Region: HTH_21; pfam13276 1274814010402 Integrase core domain; Region: rve; pfam00665 1274814010403 Integrase core domain; Region: rve_3; pfam13683 1274814010404 IS2 repressor TnpA; Reviewed; Region: PRK09413 1274814010405 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814010406 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1274814010407 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 1274814010408 active site 1274814010409 catalytic site [active] 1274814010410 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; cl02706 1274814010411 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 1274814010412 substrate binding pocket [chemical binding]; other site 1274814010413 active site 1274814010414 iron coordination sites [ion binding]; other site 1274814010415 Predicted dehydrogenase [General function prediction only]; Region: COG0579 1274814010416 hydroxyglutarate oxidase; Provisional; Region: PRK11728 1274814010417 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 1274814010418 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 1274814010419 tetramerization interface [polypeptide binding]; other site 1274814010420 NAD(P) binding site [chemical binding]; other site 1274814010421 catalytic residues [active] 1274814010422 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 1274814010423 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1274814010424 inhibitor-cofactor binding pocket; inhibition site 1274814010425 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814010426 catalytic residue [active] 1274814010427 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 1274814010428 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 1274814010429 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814010430 DNA-binding site [nucleotide binding]; DNA binding site 1274814010431 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1274814010432 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 1274814010433 bacterial OsmY and nodulation domain; Region: BON; smart00749 1274814010434 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1274814010435 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 1274814010436 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1274814010437 dimerization interface [polypeptide binding]; other site 1274814010438 putative DNA binding site [nucleotide binding]; other site 1274814010439 Transcriptional regulators [Transcription]; Region: MarR; COG1846 1274814010440 putative Zn2+ binding site [ion binding]; other site 1274814010441 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 1274814010442 active site residue [active] 1274814010443 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 1274814010444 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 1274814010445 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 1274814010446 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 1274814010447 hypothetical protein; Provisional; Region: PRK10556 1274814010448 hypothetical protein; Provisional; Region: PRK10132 1274814010449 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 1274814010450 catalytic residues [active] 1274814010451 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 1274814010452 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 1274814010453 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 1274814010454 Class I ribonucleotide reductase; Region: RNR_I; cd01679 1274814010455 active site 1274814010456 dimer interface [polypeptide binding]; other site 1274814010457 catalytic residues [active] 1274814010458 effector binding site; other site 1274814010459 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 1274814010460 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 1274814010461 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 1274814010462 dimer interface [polypeptide binding]; other site 1274814010463 putative radical transfer pathway; other site 1274814010464 diiron center [ion binding]; other site 1274814010465 tyrosyl radical; other site 1274814010466 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 1274814010467 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 1274814010468 Walker A/P-loop; other site 1274814010469 ATP binding site [chemical binding]; other site 1274814010470 Q-loop/lid; other site 1274814010471 ABC transporter signature motif; other site 1274814010472 Walker B; other site 1274814010473 D-loop; other site 1274814010474 H-loop/switch region; other site 1274814010475 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 1274814010476 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 1274814010477 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814010478 dimer interface [polypeptide binding]; other site 1274814010479 conserved gate region; other site 1274814010480 putative PBP binding loops; other site 1274814010481 ABC-ATPase subunit interface; other site 1274814010482 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 1274814010483 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 1274814010484 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 1274814010485 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814010486 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 1274814010487 putative L-valine exporter; Provisional; Region: PRK10408 1274814010488 transcriptional repressor MprA; Provisional; Region: PRK10870 1274814010489 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 1274814010490 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 1274814010491 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1274814010492 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814010493 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 1274814010494 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814010495 putative substrate translocation pore; other site 1274814010496 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814010497 S-ribosylhomocysteinase; Provisional; Region: PRK02260 1274814010498 glutamate--cysteine ligase; Provisional; Region: PRK02107 1274814010499 Predicted membrane protein [Function unknown]; Region: COG1238 1274814010500 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 1274814010501 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814010502 motif II; other site 1274814010503 carbon storage regulator; Provisional; Region: PRK01712 1274814010504 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 1274814010505 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 1274814010506 motif 1; other site 1274814010507 active site 1274814010508 motif 2; other site 1274814010509 motif 3; other site 1274814010510 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 1274814010511 DHHA1 domain; Region: DHHA1; pfam02272 1274814010512 recombination regulator RecX; Reviewed; Region: recX; PRK00117 1274814010513 recombinase A; Provisional; Region: recA; PRK09354 1274814010514 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 1274814010515 hexamer interface [polypeptide binding]; other site 1274814010516 Walker A motif; other site 1274814010517 ATP binding site [chemical binding]; other site 1274814010518 Walker B motif; other site 1274814010519 hypothetical protein; Validated; Region: PRK03661 1274814010520 Transglycosylase SLT domain; Region: SLT_2; pfam13406 1274814010521 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1274814010522 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1274814010523 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 1274814010524 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 1274814010525 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 1274814010526 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 1274814010527 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 1274814010528 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 1274814010529 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 1274814010530 putative NAD(P) binding site [chemical binding]; other site 1274814010531 active site 1274814010532 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 1274814010533 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 1274814010534 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1274814010535 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1274814010536 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 1274814010537 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1274814010538 putative active site [active] 1274814010539 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1274814010540 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 1274814010541 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1274814010542 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814010543 Walker A motif; other site 1274814010544 ATP binding site [chemical binding]; other site 1274814010545 Walker B motif; other site 1274814010546 arginine finger; other site 1274814010547 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 1274814010548 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 1274814010549 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 1274814010550 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 1274814010551 iron binding site [ion binding]; other site 1274814010552 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 1274814010553 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1274814010554 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 1274814010555 Acylphosphatase; Region: Acylphosphatase; pfam00708 1274814010556 HypF finger; Region: zf-HYPF; pfam07503 1274814010557 HypF finger; Region: zf-HYPF; pfam07503 1274814010558 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 1274814010559 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 1274814010560 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1274814010561 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1274814010562 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814010563 DNA binding site [nucleotide binding] 1274814010564 domain linker motif; other site 1274814010565 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1274814010566 dimerization interface (closed form) [polypeptide binding]; other site 1274814010567 ligand binding site [chemical binding]; other site 1274814010568 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 1274814010569 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1274814010570 active site turn [active] 1274814010571 phosphorylation site [posttranslational modification] 1274814010572 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1274814010573 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 1274814010574 beta-galactosidase; Region: BGL; TIGR03356 1274814010575 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814010576 non-specific DNA binding site [nucleotide binding]; other site 1274814010577 salt bridge; other site 1274814010578 sequence-specific DNA binding site [nucleotide binding]; other site 1274814010579 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 1274814010580 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 1274814010581 nickel binding site [ion binding]; other site 1274814010582 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 1274814010583 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 1274814010584 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 1274814010585 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1274814010586 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 1274814010587 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 1274814010588 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 1274814010589 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 1274814010590 NADH dehydrogenase; Region: NADHdh; cl00469 1274814010591 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 1274814010592 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 1274814010593 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1274814010594 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 1274814010595 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 1274814010596 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 1274814010597 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 1274814010598 hydrogenase assembly chaperone; Provisional; Region: PRK10409 1274814010599 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 1274814010600 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 1274814010601 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 1274814010602 dimerization interface [polypeptide binding]; other site 1274814010603 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 1274814010604 ATP binding site [chemical binding]; other site 1274814010605 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 1274814010606 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1274814010607 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1274814010608 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814010609 Walker A motif; other site 1274814010610 ATP binding site [chemical binding]; other site 1274814010611 Walker B motif; other site 1274814010612 arginine finger; other site 1274814010613 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 1274814010614 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 1274814010615 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 1274814010616 MutS domain I; Region: MutS_I; pfam01624 1274814010617 MutS domain II; Region: MutS_II; pfam05188 1274814010618 MutS domain III; Region: MutS_III; pfam05192 1274814010619 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 1274814010620 Walker A/P-loop; other site 1274814010621 ATP binding site [chemical binding]; other site 1274814010622 Q-loop/lid; other site 1274814010623 ABC transporter signature motif; other site 1274814010624 Walker B; other site 1274814010625 D-loop; other site 1274814010626 H-loop/switch region; other site 1274814010627 PrpA and PrpB, metallophosphatase domain; Region: MPP_PrpA_PrpB; cd07424 1274814010628 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1274814010629 active site 1274814010630 metal binding site [ion binding]; metal-binding site 1274814010631 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 1274814010632 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 1274814010633 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1274814010634 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 1274814010635 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1274814010636 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 1274814010637 putative aldolase; Validated; Region: PRK08130 1274814010638 active site 1274814010639 intersubunit interface [polypeptide binding]; other site 1274814010640 Zn2+ binding site [ion binding]; other site 1274814010641 hypothetical protein; Provisional; Region: PRK09989 1274814010642 putative transporter; Provisional; Region: PRK09821 1274814010643 GntP family permease; Region: GntP_permease; pfam02447 1274814010644 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 1274814010645 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1274814010646 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1274814010647 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1274814010648 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1274814010649 DNA binding residues [nucleotide binding] 1274814010650 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 1274814010651 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1274814010652 Peptidase family M23; Region: Peptidase_M23; pfam01551 1274814010653 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 1274814010654 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814010655 S-adenosylmethionine binding site [chemical binding]; other site 1274814010656 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 1274814010657 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 1274814010658 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 1274814010659 Permutation of conserved domain; other site 1274814010660 active site 1274814010661 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 1274814010662 homotrimer interaction site [polypeptide binding]; other site 1274814010663 zinc binding site [ion binding]; other site 1274814010664 CDP-binding sites; other site 1274814010665 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 1274814010666 substrate binding site; other site 1274814010667 dimer interface; other site 1274814010668 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 1274814010669 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 1274814010670 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 1274814010671 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 1274814010672 ligand-binding site [chemical binding]; other site 1274814010673 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 1274814010674 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 1274814010675 CysD dimerization site [polypeptide binding]; other site 1274814010676 G1 box; other site 1274814010677 putative GEF interaction site [polypeptide binding]; other site 1274814010678 GTP/Mg2+ binding site [chemical binding]; other site 1274814010679 Switch I region; other site 1274814010680 G2 box; other site 1274814010681 G3 box; other site 1274814010682 Switch II region; other site 1274814010683 G4 box; other site 1274814010684 G5 box; other site 1274814010685 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 1274814010686 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 1274814010687 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 1274814010688 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1274814010689 Active Sites [active] 1274814010690 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 1274814010691 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 1274814010692 metal binding site [ion binding]; metal-binding site 1274814010693 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 1274814010694 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 1274814010695 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 1274814010696 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 1274814010697 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 1274814010698 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 1274814010699 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 1274814010700 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 1274814010701 CRISPR-associated helicase Cas3 [Defense mechanisms]; Region: COG1203 1274814010702 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1274814010703 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cl17251 1274814010704 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 1274814010705 Hok/gef family; Region: HOK_GEF; pfam01848 1274814010706 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 1274814010707 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 1274814010708 Active Sites [active] 1274814010709 sulfite reductase subunit beta; Provisional; Region: PRK13504 1274814010710 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1274814010711 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1274814010712 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 1274814010713 Flavodoxin; Region: Flavodoxin_1; pfam00258 1274814010714 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 1274814010715 FAD binding pocket [chemical binding]; other site 1274814010716 FAD binding motif [chemical binding]; other site 1274814010717 catalytic residues [active] 1274814010718 NAD binding pocket [chemical binding]; other site 1274814010719 phosphate binding motif [ion binding]; other site 1274814010720 beta-alpha-beta structure motif; other site 1274814010721 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 1274814010722 homohexamer interface [polypeptide binding]; other site 1274814010723 putative substrate stabilizing pore; other site 1274814010724 pterin binding site; other site 1274814010725 putative oxidoreductase FixC; Provisional; Region: PRK10157 1274814010726 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 1274814010727 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 1274814010728 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 1274814010729 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 1274814010730 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 1274814010731 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 1274814010732 Ligand binding site [chemical binding]; other site 1274814010733 Electron transfer flavoprotein domain; Region: ETF; pfam01012 1274814010734 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 1274814010735 benzoate transport; Region: 2A0115; TIGR00895 1274814010736 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814010737 putative substrate translocation pore; other site 1274814010738 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 1274814010739 FAD binding domain; Region: FAD_binding_4; pfam01565 1274814010740 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 1274814010741 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1274814010742 NADP binding site [chemical binding]; other site 1274814010743 homodimer interface [polypeptide binding]; other site 1274814010744 active site 1274814010745 Major Facilitator Superfamily; Region: MFS_1; pfam07690 1274814010746 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814010747 putative substrate translocation pore; other site 1274814010748 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1274814010749 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1274814010750 nucleotide binding site [chemical binding]; other site 1274814010751 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 1274814010752 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 1274814010753 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 1274814010754 Repair protein; Region: Repair_PSII; pfam04536 1274814010755 enolase; Provisional; Region: eno; PRK00077 1274814010756 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 1274814010757 dimer interface [polypeptide binding]; other site 1274814010758 metal binding site [ion binding]; metal-binding site 1274814010759 substrate binding pocket [chemical binding]; other site 1274814010760 CTP synthetase; Validated; Region: pyrG; PRK05380 1274814010761 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 1274814010762 Catalytic site [active] 1274814010763 active site 1274814010764 UTP binding site [chemical binding]; other site 1274814010765 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 1274814010766 active site 1274814010767 putative oxyanion hole; other site 1274814010768 catalytic triad [active] 1274814010769 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 1274814010770 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 1274814010771 homodimer interface [polypeptide binding]; other site 1274814010772 metal binding site [ion binding]; metal-binding site 1274814010773 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 1274814010774 homodimer interface [polypeptide binding]; other site 1274814010775 active site 1274814010776 putative chemical substrate binding site [chemical binding]; other site 1274814010777 metal binding site [ion binding]; metal-binding site 1274814010778 toxin MazF; Provisional; Region: PRK09907 1274814010779 antitoxin MazE; Provisional; Region: PRK09798 1274814010780 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 1274814010781 HD domain; Region: HD_4; pfam13328 1274814010782 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1274814010783 synthetase active site [active] 1274814010784 NTP binding site [chemical binding]; other site 1274814010785 metal binding site [ion binding]; metal-binding site 1274814010786 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1274814010787 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1274814010788 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 1274814010789 TRAM domain; Region: TRAM; pfam01938 1274814010790 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814010791 S-adenosylmethionine binding site [chemical binding]; other site 1274814010792 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 1274814010793 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 1274814010794 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1274814010795 dimerization interface [polypeptide binding]; other site 1274814010796 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814010797 dimer interface [polypeptide binding]; other site 1274814010798 phosphorylation site [posttranslational modification] 1274814010799 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814010800 ATP binding site [chemical binding]; other site 1274814010801 Mg2+ binding site [ion binding]; other site 1274814010802 G-X-G motif; other site 1274814010803 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 1274814010804 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814010805 active site 1274814010806 phosphorylation site [posttranslational modification] 1274814010807 intermolecular recognition site; other site 1274814010808 dimerization interface [polypeptide binding]; other site 1274814010809 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1274814010810 putative binding surface; other site 1274814010811 active site 1274814010812 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1274814010813 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1274814010814 active site 1274814010815 tetramer interface [polypeptide binding]; other site 1274814010816 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 1274814010817 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 1274814010818 active site 1274814010819 tetramer interface [polypeptide binding]; other site 1274814010820 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814010821 D-galactonate transporter; Region: 2A0114; TIGR00893 1274814010822 putative substrate translocation pore; other site 1274814010823 flavodoxin; Provisional; Region: PRK08105 1274814010824 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 1274814010825 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 1274814010826 probable active site [active] 1274814010827 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 1274814010828 SecY interacting protein Syd; Provisional; Region: PRK04968 1274814010829 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 1274814010830 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 1274814010831 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 1274814010832 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 1274814010833 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 1274814010834 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1274814010835 serine transporter; Region: stp; TIGR00814 1274814010836 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 1274814010837 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1274814010838 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1274814010839 flap endonuclease-like protein; Provisional; Region: PRK09482 1274814010840 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 1274814010841 active site 1274814010842 metal binding site 1 [ion binding]; metal-binding site 1274814010843 putative 5' ssDNA interaction site; other site 1274814010844 metal binding site 3; metal-binding site 1274814010845 metal binding site 2 [ion binding]; metal-binding site 1274814010846 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 1274814010847 putative DNA binding site [nucleotide binding]; other site 1274814010848 putative metal binding site [ion binding]; other site 1274814010849 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 1274814010850 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1274814010851 dimer interface [polypeptide binding]; other site 1274814010852 active site 1274814010853 metal binding site [ion binding]; metal-binding site 1274814010854 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1274814010855 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1274814010856 intersubunit interface [polypeptide binding]; other site 1274814010857 active site 1274814010858 Zn2+ binding site [ion binding]; other site 1274814010859 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 1274814010860 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814010861 putative substrate translocation pore; other site 1274814010862 L-fucose isomerase; Provisional; Region: fucI; PRK10991 1274814010863 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 1274814010864 hexamer (dimer of trimers) interface [polypeptide binding]; other site 1274814010865 trimer interface [polypeptide binding]; other site 1274814010866 substrate binding site [chemical binding]; other site 1274814010867 Mn binding site [ion binding]; other site 1274814010868 L-fuculokinase; Provisional; Region: PRK10331 1274814010869 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1274814010870 nucleotide binding site [chemical binding]; other site 1274814010871 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 1274814010872 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 1274814010873 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1274814010874 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1274814010875 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 1274814010876 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 1274814010877 hypothetical protein; Provisional; Region: PRK10873 1274814010878 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 1274814010879 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814010880 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 1274814010881 dimerization interface [polypeptide binding]; other site 1274814010882 substrate binding pocket [chemical binding]; other site 1274814010883 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1274814010884 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 1274814010885 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 1274814010886 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1274814010887 catalytic residue [active] 1274814010888 CsdA-binding activator; Provisional; Region: PRK15019 1274814010889 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 1274814010890 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 1274814010891 putative ATP binding site [chemical binding]; other site 1274814010892 putative substrate interface [chemical binding]; other site 1274814010893 murein transglycosylase A; Provisional; Region: mltA; PRK11162 1274814010894 MltA specific insert domain; Region: MltA; pfam03562 1274814010895 3D domain; Region: 3D; pfam06725 1274814010896 AMIN domain; Region: AMIN; pfam11741 1274814010897 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 1274814010898 active site 1274814010899 metal binding site [ion binding]; metal-binding site 1274814010900 N-acetylglutamate synthase; Validated; Region: PRK05279 1274814010901 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 1274814010902 putative feedback inhibition sensing region; other site 1274814010903 putative nucleotide binding site [chemical binding]; other site 1274814010904 putative substrate binding site [chemical binding]; other site 1274814010905 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814010906 Coenzyme A binding pocket [chemical binding]; other site 1274814010907 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 1274814010908 AAA domain; Region: AAA_30; pfam13604 1274814010909 Family description; Region: UvrD_C_2; pfam13538 1274814010910 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 1274814010911 protease3; Provisional; Region: PRK15101 1274814010912 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 1274814010913 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1274814010914 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1274814010915 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 1274814010916 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 1274814010917 hypothetical protein; Provisional; Region: PRK10332 1274814010918 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 1274814010919 hypothetical protein; Provisional; Region: PRK11521 1274814010920 hypothetical protein; Provisional; Region: PRK10557 1274814010921 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1274814010922 hypothetical protein; Provisional; Region: PRK10506 1274814010923 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 1274814010924 thymidylate synthase; Reviewed; Region: thyA; PRK01827 1274814010925 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 1274814010926 dimerization interface [polypeptide binding]; other site 1274814010927 active site 1274814010928 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 1274814010929 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 1274814010930 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 1274814010931 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 1274814010932 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 1274814010933 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 1274814010934 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 1274814010935 putative active site [active] 1274814010936 Ap4A binding site [chemical binding]; other site 1274814010937 nudix motif; other site 1274814010938 putative metal binding site [ion binding]; other site 1274814010939 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 1274814010940 putative DNA-binding cleft [nucleotide binding]; other site 1274814010941 putative DNA clevage site; other site 1274814010942 molecular lever; other site 1274814010943 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 1274814010944 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 1274814010945 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1274814010946 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1274814010947 active site 1274814010948 catalytic tetrad [active] 1274814010949 lysophospholipid transporter LplT; Provisional; Region: PRK11195 1274814010950 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814010951 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 1274814010952 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1274814010953 putative acyl-acceptor binding pocket; other site 1274814010954 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 1274814010955 acyl-activating enzyme (AAE) consensus motif; other site 1274814010956 putative AMP binding site [chemical binding]; other site 1274814010957 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 1274814010958 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814010959 DNA binding site [nucleotide binding] 1274814010960 domain linker motif; other site 1274814010961 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 1274814010962 dimerization interface (closed form) [polypeptide binding]; other site 1274814010963 ligand binding site [chemical binding]; other site 1274814010964 diaminopimelate decarboxylase; Provisional; Region: PRK11165 1274814010965 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 1274814010966 active site 1274814010967 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1274814010968 substrate binding site [chemical binding]; other site 1274814010969 catalytic residues [active] 1274814010970 dimer interface [polypeptide binding]; other site 1274814010971 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 1274814010972 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814010973 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 1274814010974 putative dimerization interface [polypeptide binding]; other site 1274814010975 putative racemase; Provisional; Region: PRK10200 1274814010976 aspartate racemase; Region: asp_race; TIGR00035 1274814010977 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1274814010978 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814010979 putative substrate translocation pore; other site 1274814010980 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814010981 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 1274814010982 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 1274814010983 NADP binding site [chemical binding]; other site 1274814010984 homodimer interface [polypeptide binding]; other site 1274814010985 active site 1274814010986 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 1274814010987 putative acyltransferase; Provisional; Region: PRK05790 1274814010988 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1274814010989 dimer interface [polypeptide binding]; other site 1274814010990 active site 1274814010991 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1274814010992 serine transporter; Region: stp; TIGR00814 1274814010993 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 1274814010994 DNA binding residues [nucleotide binding] 1274814010995 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1274814010996 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 1274814010997 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 1274814010998 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 1274814010999 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1274814011000 Tetratricopeptide repeat; Region: TPR_3; pfam07720 1274814011001 transcriptional regulator; Provisional; Region: PRK11906 1274814011002 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 1274814011003 DNA binding site [nucleotide binding] 1274814011004 IS2 transposase TnpB; Reviewed; Region: PRK09409 1274814011005 HTH-like domain; Region: HTH_21; pfam13276 1274814011006 Integrase core domain; Region: rve; pfam00665 1274814011007 Integrase core domain; Region: rve_3; pfam13683 1274814011008 IS2 repressor TnpA; Reviewed; Region: PRK09413 1274814011009 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814011010 TPR motif; other site 1274814011011 Tetratricopeptide repeat; Region: TPR_2; pfam07719 1274814011012 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 1274814011013 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1274814011014 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1274814011015 catalytic residue [active] 1274814011016 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1274814011017 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814011018 DNA binding residues [nucleotide binding] 1274814011019 dimerization interface [polypeptide binding]; other site 1274814011020 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1274814011021 invasion protein OrgB; Provisional; Region: PRK15322 1274814011022 type III secretion apparatus protein OrgA/MxiK; Region: OrgA_MxiK; TIGR02555 1274814011023 Type III secretory pathway, lipoprotein EscJ [Intracellular trafficking and secretion]; Region: EscJ; COG4669 1274814011024 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 1274814011025 Type III secretion needle MxiH like; Region: MxiH; cl09641 1274814011026 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 1274814011027 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 1274814011028 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814011029 DNA binding residues [nucleotide binding] 1274814011030 dimerization interface [polypeptide binding]; other site 1274814011031 InvH outer membrane lipoprotein; Region: InvH; pfam04741 1274814011032 type III secretion system protein SpaS; Validated; Region: PRK08156 1274814011033 type III secretion system protein SpaS; Validated; Region: PRK08156 1274814011034 type III secretion system protein SpaS; Validated; Region: PRK08156 1274814011035 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 1274814011036 type III secretion system protein SpaQ; Provisional; Region: PRK15333 1274814011037 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 1274814011038 type III secretion system protein SpaO; Validated; Region: PRK08158 1274814011039 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 1274814011040 Surface presentation of antigens protein; Region: SPAN; pfam02510 1274814011041 Salmonella surface presentation of antigen gene type M protein; Region: SPAM; cl03442 1274814011042 potential frameshift: common BLAST hit: gi|386625584|ref|YP_006145312.1| flagellum-specific ATP synthase 1274814011043 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; cl07980 1274814011044 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 1274814011045 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 1274814011046 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 1274814011047 Peptidase family M23; Region: Peptidase_M23; pfam01551 1274814011048 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 1274814011049 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1274814011050 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1274814011051 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 1274814011052 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1274814011053 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 1274814011054 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 1274814011055 catalytic loop [active] 1274814011056 iron binding site [ion binding]; other site 1274814011057 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1274814011058 GAF domain; Region: GAF; cl17456 1274814011059 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 1274814011060 PAS domain; Region: PAS; smart00091 1274814011061 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814011062 Walker A motif; other site 1274814011063 ATP binding site [chemical binding]; other site 1274814011064 Walker B motif; other site 1274814011065 arginine finger; other site 1274814011066 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 1274814011067 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 1274814011068 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 1274814011069 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 1274814011070 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1274814011071 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 1274814011072 catalytic residue [active] 1274814011073 peptidase; Reviewed; Region: PRK13004 1274814011074 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 1274814011075 putative metal binding site [ion binding]; other site 1274814011076 putative dimer interface [polypeptide binding]; other site 1274814011077 D-hydantoinase; Region: D-hydantoinase; TIGR02033 1274814011078 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 1274814011079 tetramer interface [polypeptide binding]; other site 1274814011080 active site 1274814011081 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 1274814011082 carbamate kinase; Reviewed; Region: PRK12686 1274814011083 putative substrate binding site [chemical binding]; other site 1274814011084 homodimer interface [polypeptide binding]; other site 1274814011085 nucleotide binding site [chemical binding]; other site 1274814011086 nucleotide binding site [chemical binding]; other site 1274814011087 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 1274814011088 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 1274814011089 XdhC Rossmann domain; Region: XdhC_C; pfam13478 1274814011090 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 1274814011091 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 1274814011092 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 1274814011093 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 1274814011094 Ligand binding site; other site 1274814011095 metal-binding site 1274814011096 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 1274814011097 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1274814011098 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1274814011099 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 1274814011100 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 1274814011101 active site 1274814011102 putative substrate binding pocket [chemical binding]; other site 1274814011103 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 1274814011104 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 1274814011105 putative hypoxanthine oxidase; Provisional; Region: PRK09800 1274814011106 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 1274814011107 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 1274814011108 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 1274814011109 uracil-xanthine permease; Region: ncs2; TIGR00801 1274814011110 guanine deaminase; Provisional; Region: PRK09228 1274814011111 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 1274814011112 active site 1274814011113 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1274814011114 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1274814011115 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 1274814011116 4Fe-4S binding domain; Region: Fer4; pfam00037 1274814011117 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 1274814011118 xanthine permease; Region: pbuX; TIGR03173 1274814011119 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 1274814011120 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 1274814011121 active site 1274814011122 metal binding site [ion binding]; metal-binding site 1274814011123 nudix motif; other site 1274814011124 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 1274814011125 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 1274814011126 dimer interface [polypeptide binding]; other site 1274814011127 putative anticodon binding site; other site 1274814011128 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 1274814011129 motif 1; other site 1274814011130 active site 1274814011131 motif 2; other site 1274814011132 motif 3; other site 1274814011133 peptide chain release factor 2; Provisional; Region: PRK08787 1274814011134 This domain is found in peptide chain release factors; Region: PCRF; smart00937 1274814011135 RF-1 domain; Region: RF-1; pfam00472 1274814011136 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 1274814011137 DHH family; Region: DHH; pfam01368 1274814011138 DHHA1 domain; Region: DHHA1; pfam02272 1274814011139 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 1274814011140 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 1274814011141 dimerization domain [polypeptide binding]; other site 1274814011142 dimer interface [polypeptide binding]; other site 1274814011143 catalytic residues [active] 1274814011144 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 1274814011145 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 1274814011146 active site 1274814011147 Int/Topo IB signature motif; other site 1274814011148 flavodoxin FldB; Provisional; Region: PRK12359 1274814011149 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 1274814011150 hypothetical protein; Provisional; Region: PRK10878 1274814011151 putative global regulator; Reviewed; Region: PRK09559 1274814011152 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 1274814011153 hemolysin; Provisional; Region: PRK15087 1274814011154 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 1274814011155 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 1274814011156 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 1274814011157 beta-galactosidase; Region: BGL; TIGR03356 1274814011158 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 1274814011159 classical (c) SDRs; Region: SDR_c; cd05233 1274814011160 NAD(P) binding site [chemical binding]; other site 1274814011161 active site 1274814011162 glycine dehydrogenase; Provisional; Region: PRK05367 1274814011163 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1274814011164 tetramer interface [polypeptide binding]; other site 1274814011165 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814011166 catalytic residue [active] 1274814011167 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 1274814011168 tetramer interface [polypeptide binding]; other site 1274814011169 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814011170 catalytic residue [active] 1274814011171 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 1274814011172 lipoyl attachment site [posttranslational modification]; other site 1274814011173 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 1274814011174 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 1274814011175 oxidoreductase; Provisional; Region: PRK08013 1274814011176 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1274814011177 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 1274814011178 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 1274814011179 proline aminopeptidase P II; Provisional; Region: PRK10879 1274814011180 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 1274814011181 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1274814011182 active site 1274814011183 hypothetical protein; Reviewed; Region: PRK01736 1274814011184 Z-ring-associated protein; Provisional; Region: PRK10972 1274814011185 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 1274814011186 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 1274814011187 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 1274814011188 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 1274814011189 ligand binding site [chemical binding]; other site 1274814011190 NAD binding site [chemical binding]; other site 1274814011191 tetramer interface [polypeptide binding]; other site 1274814011192 catalytic site [active] 1274814011193 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 1274814011194 L-serine binding site [chemical binding]; other site 1274814011195 ACT domain interface; other site 1274814011196 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 1274814011197 tetramer (dimer of dimers) interface [polypeptide binding]; other site 1274814011198 active site 1274814011199 dimer interface [polypeptide binding]; other site 1274814011200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1274814011201 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 1274814011202 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814011203 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 1274814011204 putative dimerization interface [polypeptide binding]; other site 1274814011205 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 1274814011206 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 1274814011207 active site 1274814011208 substrate binding site [chemical binding]; other site 1274814011209 coenzyme B12 binding site [chemical binding]; other site 1274814011210 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 1274814011211 B12 binding site [chemical binding]; other site 1274814011212 cobalt ligand [ion binding]; other site 1274814011213 membrane ATPase/protein kinase; Provisional; Region: PRK09435 1274814011214 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 1274814011215 Walker A; other site 1274814011216 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 1274814011217 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1274814011218 substrate binding site [chemical binding]; other site 1274814011219 oxyanion hole (OAH) forming residues; other site 1274814011220 trimer interface [polypeptide binding]; other site 1274814011221 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 1274814011222 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 1274814011223 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 1274814011224 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814011225 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1274814011226 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1274814011227 dimerization interface [polypeptide binding]; other site 1274814011228 Uncharacterized conserved protein [Function unknown]; Region: COG2968 1274814011229 oxidative stress defense protein; Provisional; Region: PRK11087 1274814011230 arginine exporter protein; Provisional; Region: PRK09304 1274814011231 mechanosensitive channel MscS; Provisional; Region: PRK10334 1274814011232 Mechanosensitive ion channel; Region: MS_channel; pfam00924 1274814011233 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814011234 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1274814011235 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 1274814011236 active site 1274814011237 intersubunit interface [polypeptide binding]; other site 1274814011238 zinc binding site [ion binding]; other site 1274814011239 Na+ binding site [ion binding]; other site 1274814011240 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 1274814011241 Phosphoglycerate kinase; Region: PGK; pfam00162 1274814011242 substrate binding site [chemical binding]; other site 1274814011243 hinge regions; other site 1274814011244 ADP binding site [chemical binding]; other site 1274814011245 catalytic site [active] 1274814011246 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 1274814011247 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 1274814011248 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 1274814011249 Domain of unknown function found in archaea, bacteria, and plants; Region: DUF296; cd11378 1274814011250 trimer interface [polypeptide binding]; other site 1274814011251 putative Zn binding site [ion binding]; other site 1274814011252 ABC-type cobalt transport system, permease component CbiQ and related transporters [Inorganic ion transport and metabolism]; Region: CbiQ; COG0619 1274814011253 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1274814011254 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1274814011255 Walker A/P-loop; other site 1274814011256 ATP binding site [chemical binding]; other site 1274814011257 Q-loop/lid; other site 1274814011258 ABC transporter signature motif; other site 1274814011259 Walker B; other site 1274814011260 D-loop; other site 1274814011261 H-loop/switch region; other site 1274814011262 ABC-type cobalt transport system, ATPase component [Inorganic ion transport and metabolism]; Region: CbiO; COG1122 1274814011263 First domain of the ATP-binding cassette component of cobalt transport system; Region: ABC_cobalt_CbiO_domain1; cd03225 1274814011264 Walker A/P-loop; other site 1274814011265 ATP binding site [chemical binding]; other site 1274814011266 Q-loop/lid; other site 1274814011267 ABC transporter signature motif; other site 1274814011268 Walker B; other site 1274814011269 D-loop; other site 1274814011270 H-loop/switch region; other site 1274814011271 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 1274814011272 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1274814011273 active site 1274814011274 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1274814011275 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 1274814011276 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 1274814011277 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 1274814011278 putative active site [active] 1274814011279 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 1274814011280 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 1274814011281 putative NAD(P) binding site [chemical binding]; other site 1274814011282 catalytic Zn binding site [ion binding]; other site 1274814011283 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 1274814011284 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1274814011285 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1274814011286 active site 1274814011287 P-loop; other site 1274814011288 phosphorylation site [posttranslational modification] 1274814011289 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1274814011290 active site 1274814011291 phosphorylation site [posttranslational modification] 1274814011292 transketolase; Reviewed; Region: PRK12753 1274814011293 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 1274814011294 TPP-binding site [chemical binding]; other site 1274814011295 dimer interface [polypeptide binding]; other site 1274814011296 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 1274814011297 PYR/PP interface [polypeptide binding]; other site 1274814011298 dimer interface [polypeptide binding]; other site 1274814011299 TPP binding site [chemical binding]; other site 1274814011300 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 1274814011301 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 1274814011302 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 1274814011303 agmatinase; Region: agmatinase; TIGR01230 1274814011304 oligomer interface [polypeptide binding]; other site 1274814011305 putative active site [active] 1274814011306 Mn binding site [ion binding]; other site 1274814011307 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 1274814011308 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 1274814011309 dimer interface [polypeptide binding]; other site 1274814011310 active site 1274814011311 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1274814011312 catalytic residues [active] 1274814011313 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 1274814011314 Virulence promoting factor; Region: YqgB; pfam11036 1274814011315 Protein of unknown function (DUF2684); Region: DUF2684; pfam10885 1274814011316 S-adenosylmethionine synthetase; Validated; Region: PRK05250 1274814011317 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 1274814011318 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 1274814011319 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 1274814011320 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 1274814011321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814011322 putative substrate translocation pore; other site 1274814011323 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814011324 hypothetical protein; Provisional; Region: PRK04860 1274814011325 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 1274814011326 DNA-specific endonuclease I; Provisional; Region: PRK15137 1274814011327 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 1274814011328 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 1274814011329 RNA methyltransferase, RsmE family; Region: TIGR00046 1274814011330 glutathione synthetase; Provisional; Region: PRK05246 1274814011331 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 1274814011332 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 1274814011333 hypothetical protein; Validated; Region: PRK00228 1274814011334 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 1274814011335 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 1274814011336 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 1274814011337 Walker A motif; other site 1274814011338 ATP binding site [chemical binding]; other site 1274814011339 Walker B motif; other site 1274814011340 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 1274814011341 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1274814011342 catalytic residue [active] 1274814011343 YGGT family; Region: YGGT; pfam02325 1274814011344 YGGT family; Region: YGGT; pfam02325 1274814011345 hypothetical protein; Validated; Region: PRK05090 1274814011346 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 1274814011347 active site 1274814011348 dimerization interface [polypeptide binding]; other site 1274814011349 HemN family oxidoreductase; Provisional; Region: PRK05660 1274814011350 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814011351 FeS/SAM binding site; other site 1274814011352 HemN C-terminal domain; Region: HemN_C; pfam06969 1274814011353 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 1274814011354 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 1274814011355 homodimer interface [polypeptide binding]; other site 1274814011356 active site 1274814011357 hypothetical protein; Provisional; Region: PRK10626 1274814011358 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 1274814011359 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814011360 hypothetical protein; Provisional; Region: PRK11702 1274814011361 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 1274814011362 adenine DNA glycosylase; Provisional; Region: PRK10880 1274814011363 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 1274814011364 minor groove reading motif; other site 1274814011365 helix-hairpin-helix signature motif; other site 1274814011366 substrate binding pocket [chemical binding]; other site 1274814011367 active site 1274814011368 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 1274814011369 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 1274814011370 DNA binding and oxoG recognition site [nucleotide binding] 1274814011371 oxidative damage protection protein; Provisional; Region: PRK05408 1274814011372 murein transglycosylase C; Provisional; Region: mltC; PRK11671 1274814011373 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 1274814011374 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 1274814011375 N-acetyl-D-glucosamine binding site [chemical binding]; other site 1274814011376 catalytic residue [active] 1274814011377 nucleoside transporter; Region: 2A0110; TIGR00889 1274814011378 ornithine decarboxylase; Provisional; Region: PRK13578 1274814011379 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 1274814011380 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 1274814011381 homodimer interface [polypeptide binding]; other site 1274814011382 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814011383 catalytic residue [active] 1274814011384 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 1274814011385 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 1274814011386 putative general secretion pathway protein YghD; Provisional; Region: PRK09731 1274814011387 type II secretion system protein L; Region: typeII_sec_gspL; TIGR01709 1274814011388 GspL-like protein; Provisional; Region: PRK09662 1274814011389 Type II secretion system (T2SS), protein K; Region: T2SK; pfam03934 1274814011390 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1274814011391 type II secretion system protein J; Region: gspJ; TIGR01711 1274814011392 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1274814011393 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1274814011394 Prokaryotic N-terminal methylation motif; Region: N_methyl; pfam07963 1274814011395 Type II transport protein GspH; Region: GspH; pfam12019 1274814011396 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1274814011397 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1274814011398 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1274814011399 potential frameshift: common BLAST hit: gi|260869722|ref|YP_003236124.1| putative type II secretion protein GspF 1274814011400 type II secretion system protein E; Region: type_II_gspE; TIGR02533 1274814011401 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1274814011402 Walker A motif; other site 1274814011403 ATP binding site [chemical binding]; other site 1274814011404 Walker B motif; other site 1274814011405 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1274814011406 L-lactate permease; Region: Lactate_perm; cl00701 1274814011407 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 1274814011408 active site 1274814011409 hypothetical protein; Provisional; Region: PRK09732 1274814011410 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 1274814011411 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 1274814011412 Cysteine-rich domain; Region: CCG; pfam02754 1274814011413 Cysteine-rich domain; Region: CCG; pfam02754 1274814011414 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 1274814011415 FAD binding domain; Region: FAD_binding_4; pfam01565 1274814011416 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 1274814011417 FAD binding domain; Region: FAD_binding_4; pfam01565 1274814011418 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 1274814011419 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814011420 DNA-binding site [nucleotide binding]; DNA binding site 1274814011421 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1274814011422 acyl-CoA synthetase; Validated; Region: PRK09192 1274814011423 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 1274814011424 acyl-activating enzyme (AAE) consensus motif; other site 1274814011425 active site 1274814011426 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 1274814011427 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 1274814011428 NAD(P) binding site [chemical binding]; other site 1274814011429 active site 1274814011430 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 1274814011431 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1274814011432 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1274814011433 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1274814011434 catalytic residue [active] 1274814011435 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 1274814011436 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1274814011437 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 1274814011438 Predicted permeases [General function prediction only]; Region: COG0795 1274814011439 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 1274814011440 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1274814011441 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 1274814011442 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 1274814011443 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 1274814011444 active site 1274814011445 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1274814011446 TMP-binding site; other site 1274814011447 ATP-binding site [chemical binding]; other site 1274814011448 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 1274814011449 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 1274814011450 TMP-binding site; other site 1274814011451 ATP-binding site [chemical binding]; other site 1274814011452 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1274814011453 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1274814011454 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 1274814011455 CHAP domain; Region: CHAP; pfam05257 1274814011456 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1274814011457 putative S-transferase; Provisional; Region: PRK11752 1274814011458 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 1274814011459 C-terminal domain interface [polypeptide binding]; other site 1274814011460 GSH binding site (G-site) [chemical binding]; other site 1274814011461 dimer interface [polypeptide binding]; other site 1274814011462 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 1274814011463 dimer interface [polypeptide binding]; other site 1274814011464 N-terminal domain interface [polypeptide binding]; other site 1274814011465 active site 1274814011466 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 1274814011467 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 1274814011468 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 1274814011469 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 1274814011470 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 1274814011471 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 1274814011472 putative substrate-binding site; other site 1274814011473 nickel binding site [ion binding]; other site 1274814011474 hydrogenase 2 large subunit; Provisional; Region: PRK10467 1274814011475 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 1274814011476 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 1274814011477 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 1274814011478 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 1274814011479 4Fe-4S binding domain; Region: Fer4_6; pfam12837 1274814011480 hydrogenase 2 small subunit; Provisional; Region: PRK10468 1274814011481 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 1274814011482 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 1274814011483 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 1274814011484 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1274814011485 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 1274814011486 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1274814011487 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1274814011488 active site 1274814011489 catalytic tetrad [active] 1274814011490 hypothetical protein; Provisional; Region: PRK05208 1274814011491 oxidoreductase; Provisional; Region: PRK07985 1274814011492 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 1274814011493 NAD binding site [chemical binding]; other site 1274814011494 metal binding site [ion binding]; metal-binding site 1274814011495 active site 1274814011496 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814011497 biopolymer transport protein ExbD; Provisional; Region: PRK11267 1274814011498 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 1274814011499 biopolymer transport protein ExbB; Provisional; Region: PRK10414 1274814011500 cystathionine beta-lyase; Provisional; Region: PRK08114 1274814011501 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 1274814011502 homodimer interface [polypeptide binding]; other site 1274814011503 substrate-cofactor binding pocket; other site 1274814011504 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814011505 catalytic residue [active] 1274814011506 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1274814011507 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1274814011508 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 1274814011509 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 1274814011510 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814011511 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814011512 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 1274814011513 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 1274814011514 dimer interface [polypeptide binding]; other site 1274814011515 active site 1274814011516 metal binding site [ion binding]; metal-binding site 1274814011517 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 1274814011518 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 1274814011519 active site 1274814011520 catalytic tetrad [active] 1274814011521 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 1274814011522 putative outer membrane lipoprotein; Provisional; Region: PRK09973 1274814011523 hypothetical protein; Provisional; Region: PRK01254 1274814011524 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 1274814011525 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 1274814011526 FtsI repressor; Provisional; Region: PRK10883 1274814011527 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 1274814011528 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 1274814011529 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 1274814011530 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 1274814011531 putative acyl-acceptor binding pocket; other site 1274814011532 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 1274814011533 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 1274814011534 CAP-like domain; other site 1274814011535 active site 1274814011536 primary dimer interface [polypeptide binding]; other site 1274814011537 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 1274814011538 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 1274814011539 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 1274814011540 peptide binding site [polypeptide binding]; other site 1274814011541 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 1274814011542 toxin interface [polypeptide binding]; other site 1274814011543 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 1274814011544 Zn binding site [ion binding]; other site 1274814011545 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814011546 non-specific DNA binding site [nucleotide binding]; other site 1274814011547 salt bridge; other site 1274814011548 sequence-specific DNA binding site [nucleotide binding]; other site 1274814011549 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 1274814011550 peptide binding site [polypeptide binding]; other site 1274814011551 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 1274814011552 TIGR00156 family protein; Region: TIGR00156 1274814011553 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 1274814011554 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814011555 active site 1274814011556 phosphorylation site [posttranslational modification] 1274814011557 intermolecular recognition site; other site 1274814011558 dimerization interface [polypeptide binding]; other site 1274814011559 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814011560 DNA binding site [nucleotide binding] 1274814011561 sensor protein QseC; Provisional; Region: PRK10337 1274814011562 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814011563 dimer interface [polypeptide binding]; other site 1274814011564 phosphorylation site [posttranslational modification] 1274814011565 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814011566 ATP binding site [chemical binding]; other site 1274814011567 Mg2+ binding site [ion binding]; other site 1274814011568 G-X-G motif; other site 1274814011569 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 1274814011570 Uncharacterized conserved protein [Function unknown]; Region: COG1359 1274814011571 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1274814011572 melibiose:sodium symporter; Provisional; Region: PRK10429; cl15392 1274814011573 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1274814011574 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814011575 DNA-binding site [nucleotide binding]; DNA binding site 1274814011576 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1274814011577 ADP-ribosylglycohydrolase; Region: ADP_ribosyl_GH; cl00614 1274814011578 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1274814011579 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1274814011580 pfkB family carbohydrate kinase; Region: PfkB; pfam00294 1274814011581 substrate binding site [chemical binding]; other site 1274814011582 ATP binding site [chemical binding]; other site 1274814011583 Esterase-like activity of phytase; Region: Phytase-like; pfam13449 1274814011584 Oligogalacturonate-specific porin protein (KdgM); Region: KdgM; cl11629 1274814011585 Protein of unknown function (DUF2608); Region: DUF2608; pfam11019 1274814011586 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1274814011587 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 1274814011588 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814011589 ATP binding site [chemical binding]; other site 1274814011590 Mg2+ binding site [ion binding]; other site 1274814011591 G-X-G motif; other site 1274814011592 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1274814011593 anchoring element; other site 1274814011594 dimer interface [polypeptide binding]; other site 1274814011595 ATP binding site [chemical binding]; other site 1274814011596 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 1274814011597 active site 1274814011598 metal binding site [ion binding]; metal-binding site 1274814011599 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1274814011600 esterase YqiA; Provisional; Region: PRK11071 1274814011601 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 1274814011602 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 1274814011603 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 1274814011604 active site 1274814011605 metal binding site [ion binding]; metal-binding site 1274814011606 hexamer interface [polypeptide binding]; other site 1274814011607 putative dehydrogenase; Provisional; Region: PRK11039 1274814011608 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 1274814011609 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1274814011610 dimer interface [polypeptide binding]; other site 1274814011611 ADP-ribose binding site [chemical binding]; other site 1274814011612 active site 1274814011613 nudix motif; other site 1274814011614 metal binding site [ion binding]; metal-binding site 1274814011615 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 1274814011616 hypothetical protein; Provisional; Region: PRK11653 1274814011617 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 1274814011618 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 1274814011619 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 1274814011620 putative active site [active] 1274814011621 metal binding site [ion binding]; metal-binding site 1274814011622 zinc transporter ZupT; Provisional; Region: PRK04201 1274814011623 ZIP Zinc transporter; Region: Zip; pfam02535 1274814011624 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 1274814011625 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 1274814011626 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 1274814011627 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 1274814011628 putative fimbrial protein; Provisional; Region: PRK09733 1274814011629 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1274814011630 PapC N-terminal domain; Region: PapC_N; pfam13954 1274814011631 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1274814011632 PapC C-terminal domain; Region: PapC_C; pfam13953 1274814011633 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1274814011634 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1274814011635 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1274814011636 Fimbrial protein; Region: Fimbrial; pfam00419 1274814011637 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 1274814011638 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 1274814011639 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 1274814011640 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 1274814011641 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 1274814011642 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 1274814011643 putative ribose interaction site [chemical binding]; other site 1274814011644 putative ADP binding site [chemical binding]; other site 1274814011645 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 1274814011646 active site 1274814011647 nucleotide binding site [chemical binding]; other site 1274814011648 HIGH motif; other site 1274814011649 KMSKS motif; other site 1274814011650 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 1274814011651 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1274814011652 metal binding triad; other site 1274814011653 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1274814011654 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 1274814011655 metal binding triad; other site 1274814011656 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 1274814011657 Uncharacterized conserved protein [Function unknown]; Region: COG3025 1274814011658 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 1274814011659 putative active site [active] 1274814011660 putative metal binding residues [ion binding]; other site 1274814011661 signature motif; other site 1274814011662 putative triphosphate binding site [ion binding]; other site 1274814011663 CHAD domain; Region: CHAD; pfam05235 1274814011664 SH3 domain-containing protein; Provisional; Region: PRK10884 1274814011665 Bacterial SH3 domain homologues; Region: SH3b; smart00287 1274814011666 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 1274814011667 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 1274814011668 active site 1274814011669 NTP binding site [chemical binding]; other site 1274814011670 metal binding triad [ion binding]; metal-binding site 1274814011671 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 1274814011672 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1274814011673 Zn2+ binding site [ion binding]; other site 1274814011674 Mg2+ binding site [ion binding]; other site 1274814011675 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 1274814011676 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 1274814011677 homooctamer interface [polypeptide binding]; other site 1274814011678 active site 1274814011679 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 1274814011680 transcriptional activator TtdR; Provisional; Region: PRK09801 1274814011681 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814011682 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 1274814011683 putative effector binding pocket; other site 1274814011684 putative dimerization interface [polypeptide binding]; other site 1274814011685 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 1274814011686 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 1274814011687 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 1274814011688 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 1274814011689 transmembrane helices; other site 1274814011690 UGMP family protein; Validated; Region: PRK09604 1274814011691 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 1274814011692 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 1274814011693 DNA primase; Validated; Region: dnaG; PRK05667 1274814011694 CHC2 zinc finger; Region: zf-CHC2; pfam01807 1274814011695 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 1274814011696 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 1274814011697 active site 1274814011698 metal binding site [ion binding]; metal-binding site 1274814011699 interdomain interaction site; other site 1274814011700 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 1274814011701 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 1274814011702 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 1274814011703 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 1274814011704 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 1274814011705 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 1274814011706 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1274814011707 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 1274814011708 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1274814011709 DNA binding residues [nucleotide binding] 1274814011710 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 1274814011711 active site 1274814011712 SUMO-1 interface [polypeptide binding]; other site 1274814011713 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 1274814011714 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 1274814011715 FAD binding pocket [chemical binding]; other site 1274814011716 FAD binding motif [chemical binding]; other site 1274814011717 phosphate binding motif [ion binding]; other site 1274814011718 NAD binding pocket [chemical binding]; other site 1274814011719 Predicted transcriptional regulators [Transcription]; Region: COG1695 1274814011720 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 1274814011721 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1274814011722 PAS fold; Region: PAS_3; pfam08447 1274814011723 putative active site [active] 1274814011724 heme pocket [chemical binding]; other site 1274814011725 HAMP domain; Region: HAMP; pfam00672 1274814011726 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 1274814011727 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 1274814011728 dimer interface [polypeptide binding]; other site 1274814011729 putative CheW interface [polypeptide binding]; other site 1274814011730 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 1274814011731 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1274814011732 inhibitor-cofactor binding pocket; inhibition site 1274814011733 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814011734 catalytic residue [active] 1274814011735 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 1274814011736 dimer interface [polypeptide binding]; other site 1274814011737 putative tRNA-binding site [nucleotide binding]; other site 1274814011738 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 1274814011739 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814011740 DNA binding site [nucleotide binding] 1274814011741 domain linker motif; other site 1274814011742 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 1274814011743 putative dimerization interface [polypeptide binding]; other site 1274814011744 putative ligand binding site [chemical binding]; other site 1274814011745 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 1274814011746 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 1274814011747 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 1274814011748 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 1274814011749 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 1274814011750 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 1274814011751 inner membrane transporter YjeM; Provisional; Region: PRK15238 1274814011752 alpha-glucosidase; Provisional; Region: PRK10137 1274814011753 Protein of unknown function, DUF608; Region: DUF608; pfam04685 1274814011754 Trehalase; Region: Trehalase; cl17346 1274814011755 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 1274814011756 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 1274814011757 active site 1274814011758 FMN binding site [chemical binding]; other site 1274814011759 2,4-decadienoyl-CoA binding site; other site 1274814011760 catalytic residue [active] 1274814011761 4Fe-4S cluster binding site [ion binding]; other site 1274814011762 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 1274814011763 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814011764 non-specific DNA binding site [nucleotide binding]; other site 1274814011765 salt bridge; other site 1274814011766 sequence-specific DNA binding site [nucleotide binding]; other site 1274814011767 Uncharacterized protein conserved in bacteria (DUF2136); Region: DUF2136; cl01912 1274814011768 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 1274814011769 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814011770 S-adenosylmethionine binding site [chemical binding]; other site 1274814011771 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 1274814011772 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 1274814011773 putative active site [active] 1274814011774 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 1274814011775 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1274814011776 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 1274814011777 serine/threonine transporter SstT; Provisional; Region: PRK13628 1274814011778 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1274814011779 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 1274814011780 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1274814011781 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1274814011782 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1274814011783 Glucuronate isomerase; Region: UxaC; pfam02614 1274814011784 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 1274814011785 D-galactonate transporter; Region: 2A0114; TIGR00893 1274814011786 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814011787 putative substrate translocation pore; other site 1274814011788 CblD like pilus biogenesis initiator; Region: CblD; cl06460 1274814011789 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 1274814011790 IS2 transposase TnpB; Reviewed; Region: PRK09409 1274814011791 HTH-like domain; Region: HTH_21; pfam13276 1274814011792 Integrase core domain; Region: rve; pfam00665 1274814011793 Integrase core domain; Region: rve_3; pfam13683 1274814011794 IS2 repressor TnpA; Reviewed; Region: PRK09413 1274814011795 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 1274814011796 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 1274814011797 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449 1274814011798 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1274814011799 putative fimbrial protein TcfA; Provisional; Region: PRK15308 1274814011800 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 1274814011801 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814011802 DNA-binding site [nucleotide binding]; DNA binding site 1274814011803 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1274814011804 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 1274814011805 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 1274814011806 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 1274814011807 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 1274814011808 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 1274814011809 Predicted membrane protein [Function unknown]; Region: COG5393 1274814011810 YqjK-like protein; Region: YqjK; pfam13997 1274814011811 Predicted membrane protein [Function unknown]; Region: COG2259 1274814011812 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 1274814011813 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 1274814011814 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 1274814011815 putative dimer interface [polypeptide binding]; other site 1274814011816 N-terminal domain interface [polypeptide binding]; other site 1274814011817 putative substrate binding pocket (H-site) [chemical binding]; other site 1274814011818 Predicted membrane protein [Function unknown]; Region: COG3152 1274814011819 Protein of unknown function (DUF805); Region: DUF805; pfam05656 1274814011820 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814011821 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 1274814011822 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1274814011823 dimerization interface [polypeptide binding]; other site 1274814011824 Pirin-related protein [General function prediction only]; Region: COG1741 1274814011825 Pirin; Region: Pirin; pfam02678 1274814011826 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 1274814011827 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1274814011828 serine transporter; Region: stp; TIGR00814 1274814011829 L-serine dehydratase TdcG; Provisional; Region: PRK15040 1274814011830 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 1274814011831 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 1274814011832 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 1274814011833 homotrimer interaction site [polypeptide binding]; other site 1274814011834 putative active site [active] 1274814011835 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 1274814011836 Pyruvate formate lyase 1; Region: PFL1; cd01678 1274814011837 coenzyme A binding site [chemical binding]; other site 1274814011838 active site 1274814011839 catalytic residues [active] 1274814011840 glycine loop; other site 1274814011841 propionate/acetate kinase; Provisional; Region: PRK12379 1274814011842 Acetokinase family; Region: Acetate_kinase; cl17229 1274814011843 threonine/serine transporter TdcC; Provisional; Region: PRK13629 1274814011844 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1274814011845 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 1274814011846 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1274814011847 tetramer interface [polypeptide binding]; other site 1274814011848 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814011849 catalytic residue [active] 1274814011850 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 1274814011851 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814011852 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 1274814011853 putative substrate binding pocket [chemical binding]; other site 1274814011854 putative dimerization interface [polypeptide binding]; other site 1274814011855 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 1274814011856 hypothetical protein; Provisional; Region: PRK09716 1274814011857 glycerate kinase I; Provisional; Region: PRK10342 1274814011858 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 1274814011859 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 1274814011860 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 1274814011861 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814011862 D-galactonate transporter; Region: 2A0114; TIGR00893 1274814011863 putative substrate translocation pore; other site 1274814011864 galactarate dehydratase; Region: galactar-dH20; TIGR03248 1274814011865 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 1274814011866 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 1274814011867 putative regulator PrlF; Provisional; Region: PRK09974 1274814011868 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 1274814011869 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 1274814011870 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 1274814011871 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1274814011872 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1274814011873 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 1274814011874 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1274814011875 active site 1274814011876 phosphorylation site [posttranslational modification] 1274814011877 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 1274814011878 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 1274814011879 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 1274814011880 active pocket/dimerization site; other site 1274814011881 active site 1274814011882 phosphorylation site [posttranslational modification] 1274814011883 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 1274814011884 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 1274814011885 active site 1274814011886 dimer interface [polypeptide binding]; other site 1274814011887 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 1274814011888 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1274814011889 dimer interface [polypeptide binding]; other site 1274814011890 active site 1274814011891 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 1274814011892 putative active site [active] 1274814011893 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 1274814011894 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 1274814011895 active site 1274814011896 intersubunit interface [polypeptide binding]; other site 1274814011897 zinc binding site [ion binding]; other site 1274814011898 Na+ binding site [ion binding]; other site 1274814011899 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 1274814011900 active site 1274814011901 phosphorylation site [posttranslational modification] 1274814011902 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 1274814011903 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 1274814011904 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1274814011905 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1274814011906 active site 1274814011907 trimer interface [polypeptide binding]; other site 1274814011908 allosteric site; other site 1274814011909 active site lid [active] 1274814011910 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 1274814011911 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 1274814011912 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1274814011913 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1274814011914 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1274814011915 PapC N-terminal domain; Region: PapC_N; pfam13954 1274814011916 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1274814011917 PapC C-terminal domain; Region: PapC_C; pfam13953 1274814011918 Fimbrial protein; Region: Fimbrial; pfam00419 1274814011919 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 1274814011920 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 1274814011921 putative SAM binding site [chemical binding]; other site 1274814011922 putative homodimer interface [polypeptide binding]; other site 1274814011923 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 1274814011924 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 1274814011925 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 1274814011926 putative ligand binding site [chemical binding]; other site 1274814011927 TIGR00252 family protein; Region: TIGR00252 1274814011928 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 1274814011929 dimer interface [polypeptide binding]; other site 1274814011930 active site 1274814011931 outer membrane lipoprotein; Provisional; Region: PRK11023 1274814011932 BON domain; Region: BON; pfam04972 1274814011933 BON domain; Region: BON; pfam04972 1274814011934 Predicted permease; Region: DUF318; pfam03773 1274814011935 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 1274814011936 NADH(P)-binding; Region: NAD_binding_10; pfam13460 1274814011937 NAD binding site [chemical binding]; other site 1274814011938 active site 1274814011939 intracellular protease, PfpI family; Region: PfpI; TIGR01382 1274814011940 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 1274814011941 proposed catalytic triad [active] 1274814011942 conserved cys residue [active] 1274814011943 hypothetical protein; Provisional; Region: PRK03467 1274814011944 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 1274814011945 GIY-YIG motif/motif A; other site 1274814011946 putative active site [active] 1274814011947 putative metal binding site [ion binding]; other site 1274814011948 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 1274814011949 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814011950 Coenzyme A binding pocket [chemical binding]; other site 1274814011951 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 1274814011952 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1274814011953 Peptidase family U32; Region: Peptidase_U32; pfam01136 1274814011954 putative protease; Provisional; Region: PRK15447 1274814011955 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 1274814011956 hypothetical protein; Provisional; Region: PRK10508 1274814011957 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 1274814011958 tryptophan permease; Provisional; Region: PRK10483 1274814011959 aromatic amino acid transport protein; Region: araaP; TIGR00837 1274814011960 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 1274814011961 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1274814011962 ATP binding site [chemical binding]; other site 1274814011963 Mg++ binding site [ion binding]; other site 1274814011964 motif III; other site 1274814011965 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1274814011966 nucleotide binding region [chemical binding]; other site 1274814011967 ATP-binding site [chemical binding]; other site 1274814011968 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 1274814011969 putative RNA binding site [nucleotide binding]; other site 1274814011970 lipoprotein NlpI; Provisional; Region: PRK11189 1274814011971 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1274814011972 binding surface 1274814011973 TPR motif; other site 1274814011974 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 1274814011975 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 1274814011976 RNase E interface [polypeptide binding]; other site 1274814011977 trimer interface [polypeptide binding]; other site 1274814011978 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 1274814011979 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 1274814011980 RNase E interface [polypeptide binding]; other site 1274814011981 trimer interface [polypeptide binding]; other site 1274814011982 active site 1274814011983 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 1274814011984 putative nucleic acid binding region [nucleotide binding]; other site 1274814011985 G-X-X-G motif; other site 1274814011986 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 1274814011987 RNA binding site [nucleotide binding]; other site 1274814011988 domain interface; other site 1274814011989 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 1274814011990 16S/18S rRNA binding site [nucleotide binding]; other site 1274814011991 S13e-L30e interaction site [polypeptide binding]; other site 1274814011992 25S rRNA binding site [nucleotide binding]; other site 1274814011993 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 1274814011994 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 1274814011995 RNA binding site [nucleotide binding]; other site 1274814011996 active site 1274814011997 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 1274814011998 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 1274814011999 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1274814012000 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 1274814012001 translation initiation factor IF-2; Region: IF-2; TIGR00487 1274814012002 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 1274814012003 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 1274814012004 G1 box; other site 1274814012005 putative GEF interaction site [polypeptide binding]; other site 1274814012006 GTP/Mg2+ binding site [chemical binding]; other site 1274814012007 Switch I region; other site 1274814012008 G2 box; other site 1274814012009 G3 box; other site 1274814012010 Switch II region; other site 1274814012011 G4 box; other site 1274814012012 G5 box; other site 1274814012013 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 1274814012014 Translation-initiation factor 2; Region: IF-2; pfam11987 1274814012015 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 1274814012016 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 1274814012017 NusA N-terminal domain; Region: NusA_N; pfam08529 1274814012018 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 1274814012019 RNA binding site [nucleotide binding]; other site 1274814012020 homodimer interface [polypeptide binding]; other site 1274814012021 NusA-like KH domain; Region: KH_5; pfam13184 1274814012022 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 1274814012023 G-X-X-G motif; other site 1274814012024 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1274814012025 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 1274814012026 ribosome maturation protein RimP; Reviewed; Region: PRK00092 1274814012027 Sm and related proteins; Region: Sm_like; cl00259 1274814012028 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 1274814012029 putative oligomer interface [polypeptide binding]; other site 1274814012030 putative RNA binding site [nucleotide binding]; other site 1274814012031 Argininosuccinate synthase. The Argininosuccinate synthase is a urea cycle enzyme that catalyzes the penultimate step in arginine biosynthesis: the ATP-dependent ligation of citrulline to aspartate to form argininosuccinate, AMP and pyrophosphate . In...; Region: Argininosuccinate_Synthase; cd01999 1274814012032 ANP binding site [chemical binding]; other site 1274814012033 Substrate Binding Site II [chemical binding]; other site 1274814012034 Substrate Binding Site I [chemical binding]; other site 1274814012035 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 1274814012036 Sulfatase; Region: Sulfatase; pfam00884 1274814012037 Preprotein translocase SecG subunit; Region: SecG; pfam03840 1274814012038 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 1274814012039 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 1274814012040 active site 1274814012041 substrate binding site [chemical binding]; other site 1274814012042 metal binding site [ion binding]; metal-binding site 1274814012043 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 1274814012044 dihydropteroate synthase; Region: DHPS; TIGR01496 1274814012045 substrate binding pocket [chemical binding]; other site 1274814012046 dimer interface [polypeptide binding]; other site 1274814012047 inhibitor binding site; inhibition site 1274814012048 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 1274814012049 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814012050 Walker A motif; other site 1274814012051 ATP binding site [chemical binding]; other site 1274814012052 Walker B motif; other site 1274814012053 arginine finger; other site 1274814012054 Peptidase family M41; Region: Peptidase_M41; pfam01434 1274814012055 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 1274814012056 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814012057 S-adenosylmethionine binding site [chemical binding]; other site 1274814012058 RNA-binding protein YhbY; Provisional; Region: PRK10343 1274814012059 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 1274814012060 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1274814012061 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1274814012062 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 1274814012063 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 1274814012064 GTPase CgtA; Reviewed; Region: obgE; PRK12298 1274814012065 GTP1/OBG; Region: GTP1_OBG; pfam01018 1274814012066 Obg GTPase; Region: Obg; cd01898 1274814012067 G1 box; other site 1274814012068 GTP/Mg2+ binding site [chemical binding]; other site 1274814012069 Switch I region; other site 1274814012070 G2 box; other site 1274814012071 G3 box; other site 1274814012072 Switch II region; other site 1274814012073 G4 box; other site 1274814012074 G5 box; other site 1274814012075 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 1274814012076 EamA-like transporter family; Region: EamA; pfam00892 1274814012077 EamA-like transporter family; Region: EamA; pfam00892 1274814012078 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 1274814012079 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 1274814012080 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 1274814012081 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 1274814012082 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 1274814012083 substrate binding pocket [chemical binding]; other site 1274814012084 chain length determination region; other site 1274814012085 substrate-Mg2+ binding site; other site 1274814012086 catalytic residues [active] 1274814012087 aspartate-rich region 1; other site 1274814012088 active site lid residues [active] 1274814012089 aspartate-rich region 2; other site 1274814012090 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 1274814012091 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 1274814012092 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 1274814012093 hinge; other site 1274814012094 active site 1274814012095 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 1274814012096 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 1274814012097 anti sigma factor interaction site; other site 1274814012098 regulatory phosphorylation site [posttranslational modification]; other site 1274814012099 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 1274814012100 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 1274814012101 mce related protein; Region: MCE; pfam02470 1274814012102 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 1274814012103 conserved hypothetical integral membrane protein; Region: TIGR00056 1274814012104 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 1274814012105 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 1274814012106 Walker A/P-loop; other site 1274814012107 ATP binding site [chemical binding]; other site 1274814012108 Q-loop/lid; other site 1274814012109 ABC transporter signature motif; other site 1274814012110 Walker B; other site 1274814012111 D-loop; other site 1274814012112 H-loop/switch region; other site 1274814012113 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 1274814012114 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1274814012115 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 1274814012116 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 1274814012117 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 1274814012118 putative active site [active] 1274814012119 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 1274814012120 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 1274814012121 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 1274814012122 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 1274814012123 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 1274814012124 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 1274814012125 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 1274814012126 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 1274814012127 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 1274814012128 Walker A/P-loop; other site 1274814012129 ATP binding site [chemical binding]; other site 1274814012130 Q-loop/lid; other site 1274814012131 ABC transporter signature motif; other site 1274814012132 Walker B; other site 1274814012133 D-loop; other site 1274814012134 H-loop/switch region; other site 1274814012135 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 1274814012136 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 1274814012137 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 1274814012138 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 1274814012139 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 1274814012140 30S subunit binding site; other site 1274814012141 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1274814012142 active site 1274814012143 phosphorylation site [posttranslational modification] 1274814012144 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 1274814012145 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 1274814012146 dimerization domain swap beta strand [polypeptide binding]; other site 1274814012147 regulatory protein interface [polypeptide binding]; other site 1274814012148 active site 1274814012149 regulatory phosphorylation site [posttranslational modification]; other site 1274814012150 hypothetical protein; Provisional; Region: PRK10345 1274814012151 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 1274814012152 Transglycosylase; Region: Transgly; cl17702 1274814012153 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 1274814012154 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 1274814012155 conserved cys residue [active] 1274814012156 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 1274814012157 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 1274814012158 putative active site [active] 1274814012159 heme pocket [chemical binding]; other site 1274814012160 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814012161 dimer interface [polypeptide binding]; other site 1274814012162 phosphorylation site [posttranslational modification] 1274814012163 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814012164 ATP binding site [chemical binding]; other site 1274814012165 Mg2+ binding site [ion binding]; other site 1274814012166 G-X-G motif; other site 1274814012167 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814012168 active site 1274814012169 phosphorylation site [posttranslational modification] 1274814012170 intermolecular recognition site; other site 1274814012171 dimerization interface [polypeptide binding]; other site 1274814012172 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 1274814012173 putative binding surface; other site 1274814012174 active site 1274814012175 radical SAM protein, TIGR01212 family; Region: TIGR01212 1274814012176 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814012177 FeS/SAM binding site; other site 1274814012178 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 1274814012179 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 1274814012180 active site 1274814012181 dimer interface [polypeptide binding]; other site 1274814012182 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 1274814012183 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 1274814012184 active site 1274814012185 FMN binding site [chemical binding]; other site 1274814012186 substrate binding site [chemical binding]; other site 1274814012187 3Fe-4S cluster binding site [ion binding]; other site 1274814012188 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 1274814012189 domain interface; other site 1274814012190 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 1274814012191 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1274814012192 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1274814012193 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 1274814012194 Predicted nuclease of restriction endonuclease-like fold [General function prediction only]; Region: COG4804 1274814012195 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 1274814012196 N-acetylmannosamine kinase; Provisional; Region: PRK05082 1274814012197 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 1274814012198 nucleotide binding site [chemical binding]; other site 1274814012199 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 1274814012200 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 1274814012201 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 1274814012202 putative active site cavity [active] 1274814012203 putative sialic acid transporter; Provisional; Region: PRK03893 1274814012204 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814012205 putative substrate translocation pore; other site 1274814012206 N-acetylneuraminate lyase; Region: nanA; TIGR00683 1274814012207 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 1274814012208 inhibitor site; inhibition site 1274814012209 active site 1274814012210 dimer interface [polypeptide binding]; other site 1274814012211 catalytic residue [active] 1274814012212 transcriptional regulator NanR; Provisional; Region: PRK03837 1274814012213 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814012214 DNA-binding site [nucleotide binding]; DNA binding site 1274814012215 FCD domain; Region: FCD; pfam07729 1274814012216 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 1274814012217 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 1274814012218 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 1274814012219 stringent starvation protein A; Provisional; Region: sspA; PRK09481 1274814012220 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 1274814012221 C-terminal domain interface [polypeptide binding]; other site 1274814012222 putative GSH binding site (G-site) [chemical binding]; other site 1274814012223 dimer interface [polypeptide binding]; other site 1274814012224 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 1274814012225 dimer interface [polypeptide binding]; other site 1274814012226 N-terminal domain interface [polypeptide binding]; other site 1274814012227 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 1274814012228 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 1274814012229 23S rRNA interface [nucleotide binding]; other site 1274814012230 L3 interface [polypeptide binding]; other site 1274814012231 Predicted ATPase [General function prediction only]; Region: COG1485 1274814012232 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 1274814012233 hypothetical protein; Provisional; Region: PRK11677 1274814012234 serine endoprotease; Provisional; Region: PRK10139 1274814012235 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1274814012236 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1274814012237 protein binding site [polypeptide binding]; other site 1274814012238 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1274814012239 serine endoprotease; Provisional; Region: PRK10898 1274814012240 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 1274814012241 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 1274814012242 malate dehydrogenase; Provisional; Region: PRK05086 1274814012243 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 1274814012244 NAD binding site [chemical binding]; other site 1274814012245 dimerization interface [polypeptide binding]; other site 1274814012246 Substrate binding site [chemical binding]; other site 1274814012247 arginine repressor; Provisional; Region: PRK05066 1274814012248 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 1274814012249 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 1274814012250 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 1274814012251 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 1274814012252 RNAase interaction site [polypeptide binding]; other site 1274814012253 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 1274814012254 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1274814012255 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 1274814012256 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1274814012257 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814012258 efflux system membrane protein; Provisional; Region: PRK11594 1274814012259 transcriptional regulator; Provisional; Region: PRK10632 1274814012260 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814012261 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 1274814012262 putative effector binding pocket; other site 1274814012263 dimerization interface [polypeptide binding]; other site 1274814012264 protease TldD; Provisional; Region: tldD; PRK10735 1274814012265 hypothetical protein; Provisional; Region: PRK10899 1274814012266 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1274814012267 ribonuclease G; Provisional; Region: PRK11712 1274814012268 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 1274814012269 homodimer interface [polypeptide binding]; other site 1274814012270 oligonucleotide binding site [chemical binding]; other site 1274814012271 Maf-like protein; Region: Maf; pfam02545 1274814012272 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 1274814012273 active site 1274814012274 dimer interface [polypeptide binding]; other site 1274814012275 rod shape-determining protein MreD; Provisional; Region: PRK11060 1274814012276 rod shape-determining protein MreC; Region: mreC; TIGR00219 1274814012277 rod shape-determining protein MreC; Region: MreC; pfam04085 1274814012278 rod shape-determining protein MreB; Provisional; Region: PRK13927 1274814012279 MreB and similar proteins; Region: MreB_like; cd10225 1274814012280 nucleotide binding site [chemical binding]; other site 1274814012281 Mg binding site [ion binding]; other site 1274814012282 putative protofilament interaction site [polypeptide binding]; other site 1274814012283 RodZ interaction site [polypeptide binding]; other site 1274814012284 regulatory protein CsrD; Provisional; Region: PRK11059 1274814012285 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814012286 metal binding site [ion binding]; metal-binding site 1274814012287 active site 1274814012288 I-site; other site 1274814012289 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814012290 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 1274814012291 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 1274814012292 NADP binding site [chemical binding]; other site 1274814012293 dimer interface [polypeptide binding]; other site 1274814012294 Ferric reductase like transmembrane component; Region: Ferric_reduct; cl01043 1274814012295 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 1274814012296 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 1274814012297 carboxyltransferase (CT) interaction site; other site 1274814012298 biotinylation site [posttranslational modification]; other site 1274814012299 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 1274814012300 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 1274814012301 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 1274814012302 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 1274814012303 hypothetical protein; Provisional; Region: PRK10633 1274814012304 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 1274814012305 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 1274814012306 Na binding site [ion binding]; other site 1274814012307 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 1274814012308 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 1274814012309 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 1274814012310 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 1274814012311 FMN binding site [chemical binding]; other site 1274814012312 active site 1274814012313 catalytic residues [active] 1274814012314 substrate binding site [chemical binding]; other site 1274814012315 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 1274814012316 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 1274814012317 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 1274814012318 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814012319 DNA methylase; Region: N6_N4_Mtase; pfam01555 1274814012320 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 1274814012321 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 1274814012322 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1274814012323 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 1274814012324 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 1274814012325 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1274814012326 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814012327 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 1274814012328 Protein export membrane protein; Region: SecD_SecF; cl14618 1274814012329 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 1274814012330 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 1274814012331 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814012332 substrate binding pocket [chemical binding]; other site 1274814012333 membrane-bound complex binding site; other site 1274814012334 hinge residues; other site 1274814012335 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 1274814012336 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814012337 conserved gate region; other site 1274814012338 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814012339 dimer interface [polypeptide binding]; other site 1274814012340 conserved gate region; other site 1274814012341 putative PBP binding loops; other site 1274814012342 ABC-ATPase subunit interface; other site 1274814012343 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 1274814012344 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814012345 dimer interface [polypeptide binding]; other site 1274814012346 conserved gate region; other site 1274814012347 putative PBP binding loops; other site 1274814012348 ABC-ATPase subunit interface; other site 1274814012349 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 1274814012350 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 1274814012351 Walker A/P-loop; other site 1274814012352 ATP binding site [chemical binding]; other site 1274814012353 Q-loop/lid; other site 1274814012354 ABC transporter signature motif; other site 1274814012355 Walker B; other site 1274814012356 D-loop; other site 1274814012357 H-loop/switch region; other site 1274814012358 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 1274814012359 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 1274814012360 trimer interface [polypeptide binding]; other site 1274814012361 putative metal binding site [ion binding]; other site 1274814012362 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 1274814012363 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 1274814012364 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 1274814012365 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 1274814012366 shikimate binding site; other site 1274814012367 NAD(P) binding site [chemical binding]; other site 1274814012368 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 1274814012369 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1274814012370 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 1274814012371 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1274814012372 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 1274814012373 hypothetical protein; Validated; Region: PRK03430 1274814012374 hypothetical protein; Provisional; Region: PRK10736 1274814012375 DNA protecting protein DprA; Region: dprA; TIGR00732 1274814012376 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 1274814012377 active site 1274814012378 catalytic residues [active] 1274814012379 metal binding site [ion binding]; metal-binding site 1274814012380 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 1274814012381 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 1274814012382 putative active site [active] 1274814012383 substrate binding site [chemical binding]; other site 1274814012384 putative cosubstrate binding site; other site 1274814012385 catalytic site [active] 1274814012386 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 1274814012387 substrate binding site [chemical binding]; other site 1274814012388 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 1274814012389 putative RNA binding site [nucleotide binding]; other site 1274814012390 16S rRNA methyltransferase B; Provisional; Region: PRK10901 1274814012391 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814012392 S-adenosylmethionine binding site [chemical binding]; other site 1274814012393 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 1274814012394 TrkA-N domain; Region: TrkA_N; pfam02254 1274814012395 TrkA-C domain; Region: TrkA_C; pfam02080 1274814012396 TrkA-N domain; Region: TrkA_N; pfam02254 1274814012397 TrkA-C domain; Region: TrkA_C; pfam02080 1274814012398 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 1274814012399 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 1274814012400 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 1274814012401 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 1274814012402 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 1274814012403 DNA binding residues [nucleotide binding] 1274814012404 dimer interface [polypeptide binding]; other site 1274814012405 metal binding site [ion binding]; metal-binding site 1274814012406 hypothetical protein; Provisional; Region: PRK10203 1274814012407 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 1274814012408 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 1274814012409 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 1274814012410 alphaNTD homodimer interface [polypeptide binding]; other site 1274814012411 alphaNTD - beta interaction site [polypeptide binding]; other site 1274814012412 alphaNTD - beta' interaction site [polypeptide binding]; other site 1274814012413 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 1274814012414 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 1274814012415 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 1274814012416 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1274814012417 RNA binding surface [nucleotide binding]; other site 1274814012418 30S ribosomal protein S11; Validated; Region: PRK05309 1274814012419 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 1274814012420 30S ribosomal protein S13; Region: bact_S13; TIGR03631 1274814012421 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 1274814012422 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 1274814012423 SecY translocase; Region: SecY; pfam00344 1274814012424 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 1274814012425 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 1274814012426 23S rRNA binding site [nucleotide binding]; other site 1274814012427 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 1274814012428 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 1274814012429 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 1274814012430 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 1274814012431 23S rRNA interface [nucleotide binding]; other site 1274814012432 5S rRNA interface [nucleotide binding]; other site 1274814012433 L27 interface [polypeptide binding]; other site 1274814012434 L5 interface [polypeptide binding]; other site 1274814012435 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 1274814012436 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1274814012437 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 1274814012438 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 1274814012439 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 1274814012440 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 1274814012441 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 1274814012442 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 1274814012443 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 1274814012444 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 1274814012445 RNA binding site [nucleotide binding]; other site 1274814012446 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 1274814012447 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 1274814012448 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 1274814012449 23S rRNA interface [nucleotide binding]; other site 1274814012450 putative translocon interaction site; other site 1274814012451 signal recognition particle (SRP54) interaction site; other site 1274814012452 L23 interface [polypeptide binding]; other site 1274814012453 trigger factor interaction site; other site 1274814012454 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 1274814012455 23S rRNA interface [nucleotide binding]; other site 1274814012456 5S rRNA interface [nucleotide binding]; other site 1274814012457 putative antibiotic binding site [chemical binding]; other site 1274814012458 L25 interface [polypeptide binding]; other site 1274814012459 L27 interface [polypeptide binding]; other site 1274814012460 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 1274814012461 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 1274814012462 G-X-X-G motif; other site 1274814012463 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 1274814012464 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 1274814012465 protein-rRNA interface [nucleotide binding]; other site 1274814012466 putative translocon binding site; other site 1274814012467 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 1274814012468 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 1274814012469 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 1274814012470 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 1274814012471 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 1274814012472 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 1274814012473 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 1274814012474 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 1274814012475 protein secretion protein GspB; Provisional; Region: PRK09697 1274814012476 AAA domain; Region: AAA_22; pfam13401 1274814012477 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 1274814012478 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 1274814012479 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 1274814012480 type II secretion system protein D; Region: type_II_gspD; TIGR02517 1274814012481 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1274814012482 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1274814012483 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1274814012484 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1274814012485 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 1274814012486 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 1274814012487 Walker A motif; other site 1274814012488 ATP binding site [chemical binding]; other site 1274814012489 Walker B motif; other site 1274814012490 type II secretion system protein F; Region: GspF; TIGR02120 1274814012491 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1274814012492 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 1274814012493 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1274814012494 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 1274814012495 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 1274814012496 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 1274814012497 type II secretion system protein I; Region: gspI; TIGR01707 1274814012498 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 1274814012499 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 1274814012500 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 1274814012501 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 1274814012502 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 1274814012503 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 1274814012504 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 1274814012505 GspL periplasmic domain; Region: GspL_C; pfam12693 1274814012506 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 1274814012507 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 1274814012508 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 1274814012509 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 1274814012510 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 1274814012511 heme binding site [chemical binding]; other site 1274814012512 ferroxidase pore; other site 1274814012513 ferroxidase diiron center [ion binding]; other site 1274814012514 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 1274814012515 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 1274814012516 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 1274814012517 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 1274814012518 aromatic chitin/cellulose binding site residues [chemical binding]; other site 1274814012519 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 1274814012520 active site 1274814012521 elongation factor Tu; Reviewed; Region: PRK00049 1274814012522 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 1274814012523 G1 box; other site 1274814012524 GEF interaction site [polypeptide binding]; other site 1274814012525 GTP/Mg2+ binding site [chemical binding]; other site 1274814012526 Switch I region; other site 1274814012527 G2 box; other site 1274814012528 G3 box; other site 1274814012529 Switch II region; other site 1274814012530 G4 box; other site 1274814012531 G5 box; other site 1274814012532 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 1274814012533 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 1274814012534 Antibiotic Binding Site [chemical binding]; other site 1274814012535 elongation factor G; Reviewed; Region: PRK00007 1274814012536 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 1274814012537 G1 box; other site 1274814012538 putative GEF interaction site [polypeptide binding]; other site 1274814012539 GTP/Mg2+ binding site [chemical binding]; other site 1274814012540 Switch I region; other site 1274814012541 G2 box; other site 1274814012542 G3 box; other site 1274814012543 Switch II region; other site 1274814012544 G4 box; other site 1274814012545 G5 box; other site 1274814012546 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 1274814012547 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 1274814012548 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 1274814012549 30S ribosomal protein S7; Validated; Region: PRK05302 1274814012550 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 1274814012551 S17 interaction site [polypeptide binding]; other site 1274814012552 S8 interaction site; other site 1274814012553 16S rRNA interaction site [nucleotide binding]; other site 1274814012554 streptomycin interaction site [chemical binding]; other site 1274814012555 23S rRNA interaction site [nucleotide binding]; other site 1274814012556 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 1274814012557 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 1274814012558 sulfur relay protein TusC; Validated; Region: PRK00211 1274814012559 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 1274814012560 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 1274814012561 YheO-like PAS domain; Region: PAS_6; pfam08348 1274814012562 HTH domain; Region: HTH_22; pfam13309 1274814012563 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 1274814012564 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 1274814012565 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1274814012566 phi X174 lysis protein; Provisional; Region: PRK02793 1274814012567 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 1274814012568 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 1274814012569 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 1274814012570 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 1274814012571 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 1274814012572 TrkA-N domain; Region: TrkA_N; pfam02254 1274814012573 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 1274814012574 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 1274814012575 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814012576 Walker A/P-loop; other site 1274814012577 ATP binding site [chemical binding]; other site 1274814012578 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1274814012579 ABC transporter signature motif; other site 1274814012580 Walker B; other site 1274814012581 D-loop; other site 1274814012582 ABC transporter; Region: ABC_tran_2; pfam12848 1274814012583 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 1274814012584 putative hydrolase; Provisional; Region: PRK10985 1274814012585 hypothetical protein; Provisional; Region: PRK04966 1274814012586 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 1274814012587 active site 1274814012588 hypothetical protein; Provisional; Region: PRK10738 1274814012589 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 1274814012590 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 1274814012591 ligand binding site [chemical binding]; other site 1274814012592 flexible hinge region; other site 1274814012593 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 1274814012594 putative switch regulator; other site 1274814012595 non-specific DNA interactions [nucleotide binding]; other site 1274814012596 DNA binding site [nucleotide binding] 1274814012597 sequence specific DNA binding site [nucleotide binding]; other site 1274814012598 putative cAMP binding site [chemical binding]; other site 1274814012599 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 1274814012600 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 1274814012601 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 1274814012602 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 1274814012603 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 1274814012604 inhibitor-cofactor binding pocket; inhibition site 1274814012605 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814012606 catalytic residue [active] 1274814012607 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 1274814012608 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 1274814012609 glutamine binding [chemical binding]; other site 1274814012610 catalytic triad [active] 1274814012611 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 1274814012612 cell filamentation protein Fic; Provisional; Region: PRK10347 1274814012613 hypothetical protein; Provisional; Region: PRK10204 1274814012614 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 1274814012615 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 1274814012616 substrate binding site [chemical binding]; other site 1274814012617 putative transporter; Provisional; Region: PRK03699 1274814012618 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814012619 putative substrate translocation pore; other site 1274814012620 nitrite reductase subunit NirD; Provisional; Region: PRK14989 1274814012621 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1274814012622 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1274814012623 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 1274814012624 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 1274814012625 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 1274814012626 nitrite transporter NirC; Provisional; Region: PRK11562 1274814012627 siroheme synthase; Provisional; Region: cysG; PRK10637 1274814012628 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 1274814012629 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 1274814012630 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 1274814012631 active site 1274814012632 SAM binding site [chemical binding]; other site 1274814012633 homodimer interface [polypeptide binding]; other site 1274814012634 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 1274814012635 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 1274814012636 hypothetical protein; Provisional; Region: PHA02764 1274814012637 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 1274814012638 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 1274814012639 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1274814012640 dimer interface [polypeptide binding]; other site 1274814012641 active site 1274814012642 fructoselysine 3-epimerase; Provisional; Region: PRK09856 1274814012643 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 1274814012644 AP (apurinic/apyrimidinic) site pocket; other site 1274814012645 DNA interaction; other site 1274814012646 Metal-binding active site; metal-binding site 1274814012647 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 1274814012648 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1274814012649 substrate binding site [chemical binding]; other site 1274814012650 ATP binding site [chemical binding]; other site 1274814012651 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 1274814012652 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814012653 DNA-binding site [nucleotide binding]; DNA binding site 1274814012654 UTRA domain; Region: UTRA; pfam07702 1274814012655 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 1274814012656 DNA topoisomerase III, bacteria and conjugative plasmid; Region: topB; TIGR01056 1274814012657 Protein of unknown function; Region: YhfT; pfam10797 1274814012658 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 1274814012659 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 1274814012660 active site 1274814012661 substrate binding pocket [chemical binding]; other site 1274814012662 homodimer interaction site [polypeptide binding]; other site 1274814012663 putative mutase; Provisional; Region: PRK12383 1274814012664 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 1274814012665 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 1274814012666 dimer interface [polypeptide binding]; other site 1274814012667 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 1274814012668 active site 1274814012669 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 1274814012670 substrate binding site [chemical binding]; other site 1274814012671 catalytic residue [active] 1274814012672 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 1274814012673 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 1274814012674 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 1274814012675 active site 1274814012676 HIGH motif; other site 1274814012677 dimer interface [polypeptide binding]; other site 1274814012678 KMSKS motif; other site 1274814012679 phosphoglycolate phosphatase; Provisional; Region: PRK13222 1274814012680 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814012681 motif II; other site 1274814012682 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 1274814012683 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 1274814012684 substrate binding site [chemical binding]; other site 1274814012685 hexamer interface [polypeptide binding]; other site 1274814012686 metal binding site [ion binding]; metal-binding site 1274814012687 DNA adenine methylase; Provisional; Region: PRK10904 1274814012688 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 1274814012689 cell division protein DamX; Validated; Region: PRK10905 1274814012690 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 1274814012691 active site 1274814012692 dimer interface [polypeptide binding]; other site 1274814012693 metal binding site [ion binding]; metal-binding site 1274814012694 shikimate kinase; Reviewed; Region: aroK; PRK00131 1274814012695 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 1274814012696 ADP binding site [chemical binding]; other site 1274814012697 magnesium binding site [ion binding]; other site 1274814012698 putative shikimate binding site; other site 1274814012699 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 1274814012700 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 1274814012701 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 1274814012702 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 1274814012703 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 1274814012704 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 1274814012705 Tfp pilus assembly protein, ATPase PilM [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilM; COG4972 1274814012706 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 1274814012707 Transglycosylase; Region: Transgly; pfam00912 1274814012708 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 1274814012709 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 1274814012710 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 1274814012711 ADP-ribose binding site [chemical binding]; other site 1274814012712 dimer interface [polypeptide binding]; other site 1274814012713 active site 1274814012714 nudix motif; other site 1274814012715 metal binding site [ion binding]; metal-binding site 1274814012716 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 1274814012717 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 1274814012718 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814012719 motif II; other site 1274814012720 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 1274814012721 RNA binding surface [nucleotide binding]; other site 1274814012722 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 1274814012723 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 1274814012724 dimerization interface [polypeptide binding]; other site 1274814012725 domain crossover interface; other site 1274814012726 redox-dependent activation switch; other site 1274814012727 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 1274814012728 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 1274814012729 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 1274814012730 active site 1274814012731 substrate-binding site [chemical binding]; other site 1274814012732 metal-binding site [ion binding] 1274814012733 ATP binding site [chemical binding]; other site 1274814012734 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 1274814012735 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 1274814012736 dimerization interface [polypeptide binding]; other site 1274814012737 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 1274814012738 dimer interface [polypeptide binding]; other site 1274814012739 phosphorylation site [posttranslational modification] 1274814012740 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814012741 ATP binding site [chemical binding]; other site 1274814012742 G-X-G motif; other site 1274814012743 osmolarity response regulator; Provisional; Region: ompR; PRK09468 1274814012744 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814012745 active site 1274814012746 phosphorylation site [posttranslational modification] 1274814012747 intermolecular recognition site; other site 1274814012748 dimerization interface [polypeptide binding]; other site 1274814012749 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 1274814012750 DNA binding site [nucleotide binding] 1274814012751 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 1274814012752 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 1274814012753 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 1274814012754 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 1274814012755 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 1274814012756 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 1274814012757 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 1274814012758 RNA binding site [nucleotide binding]; other site 1274814012759 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 1274814012760 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 1274814012761 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 1274814012762 G1 box; other site 1274814012763 GTP/Mg2+ binding site [chemical binding]; other site 1274814012764 Switch I region; other site 1274814012765 G2 box; other site 1274814012766 G3 box; other site 1274814012767 Switch II region; other site 1274814012768 G4 box; other site 1274814012769 G5 box; other site 1274814012770 Nucleoside recognition; Region: Gate; pfam07670 1274814012771 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 1274814012772 Nucleoside recognition; Region: Gate; pfam07670 1274814012773 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 1274814012774 putative transposase; Provisional; Region: PRK09857 1274814012775 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 1274814012776 carboxylesterase BioH; Provisional; Region: PRK10349 1274814012777 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 1274814012778 DNA utilization protein GntX; Provisional; Region: PRK11595 1274814012779 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1274814012780 active site 1274814012781 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 1274814012782 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 1274814012783 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 1274814012784 high-affinity gluconate transporter; Provisional; Region: PRK14984 1274814012785 gluconate transporter; Region: gntP; TIGR00791 1274814012786 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 1274814012787 4-alpha-glucanotransferase; Region: malQ; TIGR00217 1274814012788 maltodextrin phosphorylase; Provisional; Region: PRK14985 1274814012789 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1274814012790 homodimer interface [polypeptide binding]; other site 1274814012791 active site pocket [active] 1274814012792 transcriptional regulator MalT; Provisional; Region: PRK04841 1274814012793 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814012794 DNA binding residues [nucleotide binding] 1274814012795 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 1274814012796 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 1274814012797 putative active site [active] 1274814012798 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 1274814012799 hypothetical protein; Reviewed; Region: PRK09588 1274814012800 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 1274814012801 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 1274814012802 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814012803 Walker A motif; other site 1274814012804 ATP binding site [chemical binding]; other site 1274814012805 Walker B motif; other site 1274814012806 arginine finger; other site 1274814012807 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 1274814012808 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 1274814012809 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 1274814012810 intramembrane serine protease GlpG; Provisional; Region: PRK10907 1274814012811 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 1274814012812 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 1274814012813 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 1274814012814 active site residue [active] 1274814012815 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 1274814012816 hypothetical protein; Provisional; Region: PRK09781; cl08057 1274814012817 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 1274814012818 glycogen phosphorylase; Provisional; Region: PRK14986 1274814012819 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 1274814012820 homodimer interface [polypeptide binding]; other site 1274814012821 active site pocket [active] 1274814012822 glycogen synthase; Provisional; Region: glgA; PRK00654 1274814012823 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 1274814012824 ADP-binding pocket [chemical binding]; other site 1274814012825 homodimer interface [polypeptide binding]; other site 1274814012826 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 1274814012827 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 1274814012828 ligand binding site; other site 1274814012829 oligomer interface; other site 1274814012830 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 1274814012831 sulfate 1 binding site; other site 1274814012832 glycogen debranching enzyme; Provisional; Region: PRK03705 1274814012833 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 1274814012834 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 1274814012835 active site 1274814012836 catalytic site [active] 1274814012837 glycogen branching enzyme; Provisional; Region: PRK05402 1274814012838 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 1274814012839 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 1274814012840 active site 1274814012841 catalytic site [active] 1274814012842 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 1274814012843 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 1274814012844 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 1274814012845 putative antibiotic transporter; Provisional; Region: PRK10739 1274814012846 low affinity gluconate transporter; Provisional; Region: PRK10472 1274814012847 gluconate transporter; Region: gntP; TIGR00791 1274814012848 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 1274814012849 ATP-binding site [chemical binding]; other site 1274814012850 Gluconate-6-phosphate binding site [chemical binding]; other site 1274814012851 Shikimate kinase; Region: SKI; pfam01202 1274814012852 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 1274814012853 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814012854 DNA binding site [nucleotide binding] 1274814012855 domain linker motif; other site 1274814012856 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 1274814012857 putative ligand binding site [chemical binding]; other site 1274814012858 putative dimerization interface [polypeptide binding]; other site 1274814012859 Pirin-related protein [General function prediction only]; Region: COG1741 1274814012860 Pirin; Region: Pirin; pfam02678 1274814012861 putative oxidoreductase; Provisional; Region: PRK10206 1274814012862 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 1274814012863 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 1274814012864 putative acetyltransferase YhhY; Provisional; Region: PRK10140 1274814012865 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814012866 Coenzyme A binding pocket [chemical binding]; other site 1274814012867 Dehydroquinate synthase-like (DHQ-like) and iron-containing alcohol dehydrogenases (Fe-ADH); Region: DHQ_Fe-ADH; cl02872 1274814012868 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 1274814012869 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 1274814012870 hypothetical protein; Provisional; Region: PRK10350 1274814012871 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 1274814012872 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 1274814012873 putative active site [active] 1274814012874 catalytic site [active] 1274814012875 putative metal binding site [ion binding]; other site 1274814012876 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 1274814012877 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 1274814012878 Walker A/P-loop; other site 1274814012879 ATP binding site [chemical binding]; other site 1274814012880 Q-loop/lid; other site 1274814012881 ABC transporter signature motif; other site 1274814012882 Walker B; other site 1274814012883 D-loop; other site 1274814012884 H-loop/switch region; other site 1274814012885 TOBE domain; Region: TOBE_2; pfam08402 1274814012886 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 1274814012887 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814012888 dimer interface [polypeptide binding]; other site 1274814012889 conserved gate region; other site 1274814012890 putative PBP binding loops; other site 1274814012891 ABC-ATPase subunit interface; other site 1274814012892 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 1274814012893 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814012894 dimer interface [polypeptide binding]; other site 1274814012895 conserved gate region; other site 1274814012896 putative PBP binding loops; other site 1274814012897 ABC-ATPase subunit interface; other site 1274814012898 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 1274814012899 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 1274814012900 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814012901 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814012902 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 1274814012903 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 1274814012904 Walker A/P-loop; other site 1274814012905 ATP binding site [chemical binding]; other site 1274814012906 Q-loop/lid; other site 1274814012907 ABC transporter signature motif; other site 1274814012908 Walker B; other site 1274814012909 D-loop; other site 1274814012910 H-loop/switch region; other site 1274814012911 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 1274814012912 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 1274814012913 Walker A/P-loop; other site 1274814012914 ATP binding site [chemical binding]; other site 1274814012915 Q-loop/lid; other site 1274814012916 ABC transporter signature motif; other site 1274814012917 Walker B; other site 1274814012918 D-loop; other site 1274814012919 H-loop/switch region; other site 1274814012920 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 1274814012921 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 1274814012922 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 1274814012923 TM-ABC transporter signature motif; other site 1274814012924 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1274814012925 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 1274814012926 TM-ABC transporter signature motif; other site 1274814012927 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1274814012928 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1274814012929 dimerization interface [polypeptide binding]; other site 1274814012930 ligand binding site [chemical binding]; other site 1274814012931 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 1274814012932 Acetyltransferase (GNAT) domain; Region: Acetyltransf_7; pfam13508 1274814012933 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4453 1274814012934 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 1274814012935 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 1274814012936 dimerization interface [polypeptide binding]; other site 1274814012937 ligand binding site [chemical binding]; other site 1274814012938 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 1274814012939 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 1274814012940 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 1274814012941 DNA binding residues [nucleotide binding] 1274814012942 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 1274814012943 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 1274814012944 cell division protein FtsE; Provisional; Region: PRK10908 1274814012945 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814012946 Walker A/P-loop; other site 1274814012947 ATP binding site [chemical binding]; other site 1274814012948 Q-loop/lid; other site 1274814012949 ABC transporter signature motif; other site 1274814012950 Walker B; other site 1274814012951 D-loop; other site 1274814012952 H-loop/switch region; other site 1274814012953 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 1274814012954 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 1274814012955 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 1274814012956 P loop; other site 1274814012957 GTP binding site [chemical binding]; other site 1274814012958 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 1274814012959 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814012960 S-adenosylmethionine binding site [chemical binding]; other site 1274814012961 hypothetical protein; Provisional; Region: PRK10910 1274814012962 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 1274814012963 Predicted membrane protein [Function unknown]; Region: COG3714 1274814012964 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 1274814012965 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 1274814012966 metal-binding site [ion binding] 1274814012967 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 1274814012968 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 1274814012969 CPxP motif; other site 1274814012970 hypothetical protein; Provisional; Region: PRK11212 1274814012971 hypothetical protein; Provisional; Region: PRK11615 1274814012972 major facilitator superfamily transporter; Provisional; Region: PRK05122 1274814012973 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814012974 putative substrate translocation pore; other site 1274814012975 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 1274814012976 Domain of unknown function DUF20; Region: UPF0118; pfam01594 1274814012977 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 1274814012978 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 1274814012979 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1274814012980 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 1274814012981 substrate binding site [chemical binding]; other site 1274814012982 nickel transporter permease NikB; Provisional; Region: PRK10352 1274814012983 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814012984 dimer interface [polypeptide binding]; other site 1274814012985 conserved gate region; other site 1274814012986 putative PBP binding loops; other site 1274814012987 ABC-ATPase subunit interface; other site 1274814012988 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 1274814012989 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814012990 dimer interface [polypeptide binding]; other site 1274814012991 conserved gate region; other site 1274814012992 putative PBP binding loops; other site 1274814012993 ABC-ATPase subunit interface; other site 1274814012994 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 1274814012995 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814012996 Walker A/P-loop; other site 1274814012997 ATP binding site [chemical binding]; other site 1274814012998 Q-loop/lid; other site 1274814012999 ABC transporter signature motif; other site 1274814013000 Walker B; other site 1274814013001 D-loop; other site 1274814013002 H-loop/switch region; other site 1274814013003 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 1274814013004 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 1274814013005 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814013006 Walker A/P-loop; other site 1274814013007 ATP binding site [chemical binding]; other site 1274814013008 Q-loop/lid; other site 1274814013009 ABC transporter signature motif; other site 1274814013010 Walker B; other site 1274814013011 D-loop; other site 1274814013012 H-loop/switch region; other site 1274814013013 nickel responsive regulator; Provisional; Region: PRK02967 1274814013014 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 1274814013015 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: HicB; COG4226 1274814013016 HicB family; Region: HicB; pfam05534 1274814013017 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1274814013018 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 1274814013019 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1274814013020 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 1274814013021 Walker A/P-loop; other site 1274814013022 ATP binding site [chemical binding]; other site 1274814013023 Q-loop/lid; other site 1274814013024 ABC transporter signature motif; other site 1274814013025 Walker B; other site 1274814013026 D-loop; other site 1274814013027 H-loop/switch region; other site 1274814013028 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 1274814013029 Walker A/P-loop; other site 1274814013030 ATP binding site [chemical binding]; other site 1274814013031 Q-loop/lid; other site 1274814013032 ABC transporter signature motif; other site 1274814013033 Walker B; other site 1274814013034 D-loop; other site 1274814013035 H-loop/switch region; other site 1274814013036 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 1274814013037 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 1274814013038 HlyD family secretion protein; Region: HlyD; pfam00529 1274814013039 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1274814013040 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814013041 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 1274814013042 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 1274814013043 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 1274814013044 Predicted flavoproteins [General function prediction only]; Region: COG2081 1274814013045 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1274814013046 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1274814013047 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 1274814013048 universal stress protein UspB; Provisional; Region: PRK04960 1274814013049 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 1274814013050 Ligand Binding Site [chemical binding]; other site 1274814013051 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 1274814013052 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814013053 putative substrate translocation pore; other site 1274814013054 POT family; Region: PTR2; pfam00854 1274814013055 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814013056 S-adenosylmethionine binding site [chemical binding]; other site 1274814013057 oligopeptidase A; Provisional; Region: PRK10911 1274814013058 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 1274814013059 active site 1274814013060 Zn binding site [ion binding]; other site 1274814013061 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 1274814013062 glutathione reductase; Validated; Region: PRK06116 1274814013063 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 1274814013064 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 1274814013065 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 1274814013066 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1274814013067 dimerization interface [polypeptide binding]; other site 1274814013068 putative DNA binding site [nucleotide binding]; other site 1274814013069 putative Zn2+ binding site [ion binding]; other site 1274814013070 arsenical pump membrane protein; Provisional; Region: PRK15445 1274814013071 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 1274814013072 transmembrane helices; other site 1274814013073 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 1274814013074 ArsC family; Region: ArsC; pfam03960 1274814013075 catalytic residues [active] 1274814013076 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 1274814013077 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1274814013078 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814013079 DNA binding residues [nucleotide binding] 1274814013080 dimerization interface [polypeptide binding]; other site 1274814013081 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 1274814013082 MgtC family; Region: MgtC; pfam02308 1274814013083 acid-resistance protein; Provisional; Region: hdeB; PRK11566 1274814013084 acid-resistance protein; Provisional; Region: PRK10208 1274814013085 acid-resistance membrane protein; Provisional; Region: PRK10209 1274814013086 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 1274814013087 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 1274814013088 pyruvate kinase; Provisional; Region: PRK05826 1274814013089 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 1274814013090 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1274814013091 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814013092 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 1274814013093 Protein export membrane protein; Region: SecD_SecF; cl14618 1274814013094 transcriptional regulator YdeO; Provisional; Region: PRK09940 1274814013095 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814013096 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 1274814013097 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814013098 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 1274814013099 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814013100 catalytic residue [active] 1274814013101 Haem-binding domain; Region: Haem_bd; pfam14376 1274814013102 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 1274814013103 trehalase; Provisional; Region: treF; PRK13270 1274814013104 Trehalase; Region: Trehalase; pfam01204 1274814013105 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 1274814013106 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814013107 DNA binding residues [nucleotide binding] 1274814013108 dimerization interface [polypeptide binding]; other site 1274814013109 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1274814013110 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814013111 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 1274814013112 putative effector binding pocket; other site 1274814013113 putative dimerization interface [polypeptide binding]; other site 1274814013114 inner membrane protein YhjD; Region: TIGR00766 1274814013115 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814013116 metabolite-proton symporter; Region: 2A0106; TIGR00883 1274814013117 putative substrate translocation pore; other site 1274814013118 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 1274814013119 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 1274814013120 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814013121 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1274814013122 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 1274814013123 substrate binding site [chemical binding]; other site 1274814013124 ATP binding site [chemical binding]; other site 1274814013125 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 1274814013126 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 1274814013127 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 1274814013128 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 1274814013129 putative diguanylate cyclase; Provisional; Region: PRK13561 1274814013130 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 1274814013131 metal binding site [ion binding]; metal-binding site 1274814013132 active site 1274814013133 I-site; other site 1274814013134 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 1274814013135 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 1274814013136 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1274814013137 binding surface 1274814013138 TPR motif; other site 1274814013139 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 1274814013140 binding surface 1274814013141 TPR motif; other site 1274814013142 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 1274814013143 endo-1,4-D-glucanase; Provisional; Region: PRK11097 1274814013144 cellulose synthase regulator protein; Provisional; Region: PRK11114 1274814013145 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 1274814013146 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 1274814013147 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 1274814013148 DXD motif; other site 1274814013149 PilZ domain; Region: PilZ; pfam07238 1274814013150 cell division protein; Provisional; Region: PRK10037 1274814013151 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 1274814013152 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 1274814013153 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 1274814013154 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 1274814013155 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 1274814013156 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 1274814013157 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1274814013158 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1274814013159 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1274814013160 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 1274814013161 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 1274814013162 serine transporter; Region: stp; TIGR00814 1274814013163 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 1274814013164 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814013165 Walker A/P-loop; other site 1274814013166 ATP binding site [chemical binding]; other site 1274814013167 Q-loop/lid; other site 1274814013168 ABC transporter signature motif; other site 1274814013169 Walker B; other site 1274814013170 D-loop; other site 1274814013171 H-loop/switch region; other site 1274814013172 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1274814013173 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 1274814013174 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 1274814013175 Walker A/P-loop; other site 1274814013176 ATP binding site [chemical binding]; other site 1274814013177 Q-loop/lid; other site 1274814013178 ABC transporter signature motif; other site 1274814013179 Walker B; other site 1274814013180 D-loop; other site 1274814013181 H-loop/switch region; other site 1274814013182 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 1274814013183 dipeptide transporter; Provisional; Region: PRK10913 1274814013184 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 1274814013185 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814013186 dimer interface [polypeptide binding]; other site 1274814013187 conserved gate region; other site 1274814013188 putative PBP binding loops; other site 1274814013189 ABC-ATPase subunit interface; other site 1274814013190 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 1274814013191 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814013192 dimer interface [polypeptide binding]; other site 1274814013193 conserved gate region; other site 1274814013194 putative PBP binding loops; other site 1274814013195 ABC-ATPase subunit interface; other site 1274814013196 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 1274814013197 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 1274814013198 peptide binding site [polypeptide binding]; other site 1274814013199 phosphoethanolamine transferase; Provisional; Region: PRK11560 1274814013200 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 1274814013201 Sulfatase; Region: Sulfatase; pfam00884 1274814013202 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 1274814013203 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814013204 putative substrate translocation pore; other site 1274814013205 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 1274814013206 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 1274814013207 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 1274814013208 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 1274814013209 Coenzyme A binding pocket [chemical binding]; other site 1274814013210 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 1274814013211 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 1274814013212 molybdopterin cofactor binding site [chemical binding]; other site 1274814013213 substrate binding site [chemical binding]; other site 1274814013214 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 1274814013215 molybdopterin cofactor binding site; other site 1274814013216 putative outer membrane lipoprotein; Provisional; Region: PRK10510 1274814013217 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 1274814013218 ligand binding site [chemical binding]; other site 1274814013219 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 1274814013220 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 1274814013221 dimerization interface [polypeptide binding]; other site 1274814013222 ligand binding site [chemical binding]; other site 1274814013223 NADP binding site [chemical binding]; other site 1274814013224 catalytic site [active] 1274814013225 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 1274814013226 Predicted transcriptional regulator [Transcription]; Region: COG2944 1274814013227 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 1274814013228 non-specific DNA binding site [nucleotide binding]; other site 1274814013229 salt bridge; other site 1274814013230 sequence-specific DNA binding site [nucleotide binding]; other site 1274814013231 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 1274814013232 DNA-binding site [nucleotide binding]; DNA binding site 1274814013233 RNA-binding motif; other site 1274814013234 small toxic polypeptide; Provisional; Region: PRK09759 1274814013235 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 1274814013236 DALR anticodon binding domain; Region: DALR_1; pfam05746 1274814013237 anticodon binding site; other site 1274814013238 tRNA binding surface [nucleotide binding]; other site 1274814013239 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 1274814013240 dimer interface [polypeptide binding]; other site 1274814013241 motif 1; other site 1274814013242 active site 1274814013243 motif 2; other site 1274814013244 motif 3; other site 1274814013245 YsaB-like lipoprotein; Region: YsaB; pfam13983 1274814013246 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 1274814013247 Acyltransferase family; Region: Acyl_transf_3; pfam01757 1274814013248 hypothetical protein; Provisional; Region: PRK11383 1274814013249 yiaA/B two helix domain; Region: YiaAB; pfam05360 1274814013250 yiaA/B two helix domain; Region: YiaAB; pfam05360 1274814013251 hypothetical protein; Provisional; Region: PRK11403 1274814013252 yiaA/B two helix domain; Region: YiaAB; pfam05360 1274814013253 xylulokinase; Provisional; Region: PRK15027 1274814013254 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 1274814013255 N- and C-terminal domain interface [polypeptide binding]; other site 1274814013256 active site 1274814013257 MgATP binding site [chemical binding]; other site 1274814013258 catalytic site [active] 1274814013259 metal binding site [ion binding]; metal-binding site 1274814013260 xylulose binding site [chemical binding]; other site 1274814013261 homodimer interface [polypeptide binding]; other site 1274814013262 xylose isomerase; Provisional; Region: PRK05474 1274814013263 xylose isomerase; Region: xylose_isom_A; TIGR02630 1274814013264 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 1274814013265 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 1274814013266 putative ligand binding site [chemical binding]; other site 1274814013267 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 1274814013268 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1274814013269 Walker A/P-loop; other site 1274814013270 ATP binding site [chemical binding]; other site 1274814013271 Q-loop/lid; other site 1274814013272 ABC transporter signature motif; other site 1274814013273 Walker B; other site 1274814013274 D-loop; other site 1274814013275 H-loop/switch region; other site 1274814013276 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1274814013277 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1274814013278 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1274814013279 TM-ABC transporter signature motif; other site 1274814013280 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 1274814013281 putative dimerization interface [polypeptide binding]; other site 1274814013282 Transcriptional regulators [Transcription]; Region: PurR; COG1609 1274814013283 putative ligand binding site [chemical binding]; other site 1274814013284 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814013285 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1274814013286 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814013287 hypothetical protein; Provisional; Region: PRK10356 1274814013288 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 1274814013289 alpha-amylase; Reviewed; Region: malS; PRK09505 1274814013290 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 1274814013291 active site 1274814013292 catalytic site [active] 1274814013293 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 1274814013294 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 1274814013295 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814013296 homodimer interface [polypeptide binding]; other site 1274814013297 catalytic residue [active] 1274814013298 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814013299 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 1274814013300 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 1274814013301 Transcriptional regulator [Transcription]; Region: IclR; COG1414 1274814013302 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 1274814013303 Bacterial transcriptional regulator; Region: IclR; pfam01614 1274814013304 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 1274814013305 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 1274814013306 2,3-diketo-L-gulonate TRAP transporter small permease protein YiaM; Provisional; Region: PRK09877 1274814013307 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 1274814013308 DctM-like transporters; Region: DctM; pfam06808 1274814013309 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 1274814013310 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 1274814013311 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 1274814013312 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 1274814013313 putative N- and C-terminal domain interface [polypeptide binding]; other site 1274814013314 putative active site [active] 1274814013315 MgATP binding site [chemical binding]; other site 1274814013316 catalytic site [active] 1274814013317 metal binding site [ion binding]; metal-binding site 1274814013318 putative xylulose binding site [chemical binding]; other site 1274814013319 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 1274814013320 active site 1274814013321 dimer interface [polypeptide binding]; other site 1274814013322 magnesium binding site [ion binding]; other site 1274814013323 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 1274814013324 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 1274814013325 AP (apurinic/apyrimidinic) site pocket; other site 1274814013326 DNA interaction; other site 1274814013327 Metal-binding active site; metal-binding site 1274814013328 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 1274814013329 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 1274814013330 intersubunit interface [polypeptide binding]; other site 1274814013331 active site 1274814013332 Zn2+ binding site [ion binding]; other site 1274814013333 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 1274814013334 Transcriptional regulator [Transcription]; Region: LysR; COG0583 1274814013335 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814013336 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 1274814013337 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1274814013338 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1274814013339 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814013340 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1274814013341 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 1274814013342 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 1274814013343 NAD(P) binding site [chemical binding]; other site 1274814013344 catalytic residues [active] 1274814013345 putative alcohol dehydrogenase; Provisional; Region: PRK09860 1274814013346 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 1274814013347 dimer interface [polypeptide binding]; other site 1274814013348 active site 1274814013349 metal binding site [ion binding]; metal-binding site 1274814013350 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 1274814013351 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 1274814013352 G1 box; other site 1274814013353 putative GEF interaction site [polypeptide binding]; other site 1274814013354 GTP/Mg2+ binding site [chemical binding]; other site 1274814013355 Switch I region; other site 1274814013356 G2 box; other site 1274814013357 G3 box; other site 1274814013358 Switch II region; other site 1274814013359 G4 box; other site 1274814013360 G5 box; other site 1274814013361 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 1274814013362 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 1274814013363 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 1274814013364 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 1274814013365 selenocysteine synthase; Provisional; Region: PRK04311 1274814013366 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 1274814013367 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 1274814013368 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1274814013369 catalytic residue [active] 1274814013370 putative glutathione S-transferase; Provisional; Region: PRK10357 1274814013371 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 1274814013372 putative C-terminal domain interface [polypeptide binding]; other site 1274814013373 putative GSH binding site (G-site) [chemical binding]; other site 1274814013374 putative dimer interface [polypeptide binding]; other site 1274814013375 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 1274814013376 dimer interface [polypeptide binding]; other site 1274814013377 N-terminal domain interface [polypeptide binding]; other site 1274814013378 putative substrate binding pocket (H-site) [chemical binding]; other site 1274814013379 RHS Repeat; Region: RHS_repeat; pfam05593 1274814013380 RHS Repeat; Region: RHS_repeat; cl11982 1274814013381 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1274814013382 RHS Repeat; Region: RHS_repeat; pfam05593 1274814013383 RHS Repeat; Region: RHS_repeat; pfam05593 1274814013384 RHS protein; Region: RHS; pfam03527 1274814013385 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1274814013386 putative lyase; Provisional; Region: PRK09687 1274814013387 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 1274814013388 RHS protein; Region: RHS; pfam03527 1274814013389 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 1274814013390 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 1274814013391 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 1274814013392 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 1274814013393 HlyD family secretion protein; Region: HlyD_3; pfam13437 1274814013394 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 1274814013395 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 1274814013396 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 1274814013397 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 1274814013398 active site 1274814013399 P-loop; other site 1274814013400 phosphorylation site [posttranslational modification] 1274814013401 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 1274814013402 active site 1274814013403 phosphorylation site [posttranslational modification] 1274814013404 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 1274814013405 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 1274814013406 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 1274814013407 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 1274814013408 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 1274814013409 hypothetical protein; Provisional; Region: PRK11020 1274814013410 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 1274814013411 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 1274814013412 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1274814013413 trimer interface [polypeptide binding]; other site 1274814013414 YadA-like, left-handed beta-roll; Region: LbR_YadA-like; cd12820 1274814013415 trimer interface [polypeptide binding]; other site 1274814013416 Autotransporter adhesin [Intracellular trafficking and secretion / Extracellular structures]; Region: Hia; COG5295 1274814013417 Haemagglutinin; Region: HIM; pfam05662 1274814013418 Haemagglutinin; Region: HIM; pfam05662 1274814013419 YadA-like C-terminal region; Region: YadA; pfam03895 1274814013420 L-lactate permease; Provisional; Region: PRK10420 1274814013421 glycolate transporter; Provisional; Region: PRK09695 1274814013422 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 1274814013423 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814013424 DNA-binding site [nucleotide binding]; DNA binding site 1274814013425 FCD domain; Region: FCD; pfam07729 1274814013426 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 1274814013427 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 1274814013428 phosphate binding site [ion binding]; other site 1274814013429 putative rRNA methylase; Provisional; Region: PRK10358 1274814013430 serine acetyltransferase; Provisional; Region: cysE; PRK11132 1274814013431 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 1274814013432 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 1274814013433 trimer interface [polypeptide binding]; other site 1274814013434 active site 1274814013435 substrate binding site [chemical binding]; other site 1274814013436 CoA binding site [chemical binding]; other site 1274814013437 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 1274814013438 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 1274814013439 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 1274814013440 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 1274814013441 SecA binding site; other site 1274814013442 Preprotein binding site; other site 1274814013443 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 1274814013444 GSH binding site [chemical binding]; other site 1274814013445 catalytic residues [active] 1274814013446 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 1274814013447 active site residue [active] 1274814013448 phosphoglyceromutase; Provisional; Region: PRK05434 1274814013449 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 1274814013450 AmiB activator; Provisional; Region: PRK11637 1274814013451 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1274814013452 Peptidase family M23; Region: Peptidase_M23; pfam01551 1274814013453 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 1274814013454 NodB motif; other site 1274814013455 putative active site [active] 1274814013456 putative catalytic site [active] 1274814013457 Zn binding site [ion binding]; other site 1274814013458 putative glycosyl transferase; Provisional; Region: PRK10073 1274814013459 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1274814013460 active site 1274814013461 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 1274814013462 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 1274814013463 NAD(P) binding site [chemical binding]; other site 1274814013464 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 1274814013465 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 1274814013466 substrate-cofactor binding pocket; other site 1274814013467 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814013468 catalytic residue [active] 1274814013469 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 1274814013470 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 1274814013471 NADP binding site [chemical binding]; other site 1274814013472 homopentamer interface [polypeptide binding]; other site 1274814013473 substrate binding site [chemical binding]; other site 1274814013474 active site 1274814013475 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1274814013476 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1274814013477 putative active site [active] 1274814013478 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 1274814013479 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1274814013480 putative active site [active] 1274814013481 O-Antigen ligase; Region: Wzy_C; pfam04932 1274814013482 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 1274814013483 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 1274814013484 active site 1274814013485 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1274814013486 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1274814013487 Ligand binding site; other site 1274814013488 metal-binding site 1274814013489 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1274814013490 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 1274814013491 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1274814013492 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1274814013493 Ligand binding site; other site 1274814013494 metal-binding site 1274814013495 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1274814013496 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 1274814013497 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 1274814013498 Ligand binding site; other site 1274814013499 metal-binding site 1274814013500 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 1274814013501 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 1274814013502 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 1274814013503 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 1274814013504 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 1274814013505 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 1274814013506 putative active site [active] 1274814013507 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 1274814013508 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 1274814013509 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 1274814013510 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 1274814013511 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 1274814013512 active site 1274814013513 (T/H)XGH motif; other site 1274814013514 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 1274814013515 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 1274814013516 DNA binding site [nucleotide binding] 1274814013517 catalytic residue [active] 1274814013518 H2TH interface [polypeptide binding]; other site 1274814013519 putative catalytic residues [active] 1274814013520 turnover-facilitating residue; other site 1274814013521 intercalation triad [nucleotide binding]; other site 1274814013522 8OG recognition residue [nucleotide binding]; other site 1274814013523 putative reading head residues; other site 1274814013524 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 1274814013525 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 1274814013526 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 1274814013527 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 1274814013528 hypothetical protein; Reviewed; Region: PRK00024 1274814013529 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 1274814013530 MPN+ (JAMM) motif; other site 1274814013531 Zinc-binding site [ion binding]; other site 1274814013532 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 1274814013533 Flavoprotein; Region: Flavoprotein; pfam02441 1274814013534 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 1274814013535 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 1274814013536 trimer interface [polypeptide binding]; other site 1274814013537 active site 1274814013538 division inhibitor protein; Provisional; Region: slmA; PRK09480 1274814013539 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 1274814013540 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 1274814013541 RT_Bac_retron_II: Reverse transcriptases (RTs) in bacterial retrotransposons or retrons. The polymerase reaction of this enzyme leads to the production of a unique RNA-DNA complex called msDNA (multicopy single-stranded (ss)DNA) in which a small ssDNA...; Region: RT_Bac_retron_II; cd03487 1274814013542 putative active site [active] 1274814013543 putative NTP binding site [chemical binding]; other site 1274814013544 putative nucleic acid binding site [nucleotide binding]; other site 1274814013545 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 1274814013546 active site 1274814013547 ribonuclease PH; Reviewed; Region: rph; PRK00173 1274814013548 Ribonuclease PH; Region: RNase_PH_bact; cd11362 1274814013549 hexamer interface [polypeptide binding]; other site 1274814013550 active site 1274814013551 hypothetical protein; Provisional; Region: PRK11820 1274814013552 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 1274814013553 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 1274814013554 BRO family, N-terminal domain; Region: Bro-N; cl10591 1274814013555 Predicted membrane protein [Function unknown]; Region: COG2860 1274814013556 UPF0126 domain; Region: UPF0126; pfam03458 1274814013557 UPF0126 domain; Region: UPF0126; pfam03458 1274814013558 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 1274814013559 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cl03295 1274814013560 nucleotide binding pocket [chemical binding]; other site 1274814013561 K-X-D-G motif; other site 1274814013562 catalytic site [active] 1274814013563 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 1274814013564 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 1274814013565 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 1274814013566 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 1274814013567 catalytic site [active] 1274814013568 G-X2-G-X-G-K; other site 1274814013569 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 1274814013570 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 1274814013571 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 1274814013572 Zn2+ binding site [ion binding]; other site 1274814013573 Mg2+ binding site [ion binding]; other site 1274814013574 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 1274814013575 synthetase active site [active] 1274814013576 NTP binding site [chemical binding]; other site 1274814013577 metal binding site [ion binding]; metal-binding site 1274814013578 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 1274814013579 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 1274814013580 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 1274814013581 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 1274814013582 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 1274814013583 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 1274814013584 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 1274814013585 generic binding surface II; other site 1274814013586 ssDNA binding site; other site 1274814013587 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1274814013588 ATP binding site [chemical binding]; other site 1274814013589 putative Mg++ binding site [ion binding]; other site 1274814013590 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1274814013591 nucleotide binding region [chemical binding]; other site 1274814013592 ATP-binding site [chemical binding]; other site 1274814013593 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 1274814013594 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 1274814013595 AsmA family; Region: AsmA; pfam05170 1274814013596 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 1274814013597 putative alpha-glucosidase; Provisional; Region: PRK10658 1274814013598 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 1274814013599 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 1274814013600 active site 1274814013601 homotrimer interface [polypeptide binding]; other site 1274814013602 catalytic site [active] 1274814013603 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 1274814013604 putative transporter; Provisional; Region: PRK11462 1274814013605 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 1274814013606 Virulence protein RhuM family; Region: Virulence_RhuM; pfam13310 1274814013607 sugar efflux transporter; Region: 2A0120; TIGR00899 1274814013608 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814013609 putative substrate translocation pore; other site 1274814013610 EamA-like transporter family; Region: EamA; pfam00892 1274814013611 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1274814013612 EamA-like transporter family; Region: EamA; pfam00892 1274814013613 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 1274814013614 lipoprotein, YaeC family; Region: TIGR00363 1274814013615 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 1274814013616 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 1274814013617 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814013618 putative substrate translocation pore; other site 1274814013619 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 1274814013620 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1274814013621 cryptic adenine deaminase; Provisional; Region: PRK10027 1274814013622 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 1274814013623 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 1274814013624 active site 1274814013625 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 1274814013626 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 1274814013627 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814013628 putative substrate translocation pore; other site 1274814013629 regulatory protein UhpC; Provisional; Region: PRK11663 1274814013630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814013631 putative substrate translocation pore; other site 1274814013632 sensory histidine kinase UhpB; Provisional; Region: PRK11644 1274814013633 MASE1; Region: MASE1; pfam05231 1274814013634 Histidine kinase; Region: HisKA_3; pfam07730 1274814013635 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 1274814013636 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 1274814013637 active site 1274814013638 phosphorylation site [posttranslational modification] 1274814013639 intermolecular recognition site; other site 1274814013640 dimerization interface [polypeptide binding]; other site 1274814013641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 1274814013642 DNA binding residues [nucleotide binding] 1274814013643 dimerization interface [polypeptide binding]; other site 1274814013644 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 1274814013645 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 1274814013646 putative valine binding site [chemical binding]; other site 1274814013647 dimer interface [polypeptide binding]; other site 1274814013648 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 1274814013649 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1274814013650 PYR/PP interface [polypeptide binding]; other site 1274814013651 dimer interface [polypeptide binding]; other site 1274814013652 TPP binding site [chemical binding]; other site 1274814013653 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1274814013654 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1274814013655 TPP-binding site [chemical binding]; other site 1274814013656 dimer interface [polypeptide binding]; other site 1274814013657 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 1274814013658 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814013659 putative substrate translocation pore; other site 1274814013660 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1274814013661 Domain of unknown function (DUF202); Region: DUF202; pfam02656 1274814013662 Predicted membrane protein [Function unknown]; Region: COG2149 1274814013663 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 1274814013664 Sulfatase; Region: Sulfatase; pfam00884 1274814013665 putative transporter; Provisional; Region: PRK10484 1274814013666 uncharacterized SLC5 subfamily, Escherichia coli YidK-like; solute binding domain; Region: SLC5sbd_YidK; cd10328 1274814013667 Na binding site [ion binding]; other site 1274814013668 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 1274814013669 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 1274814013670 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 1274814013671 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1274814013672 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 1274814013673 NAD-dependent, lactate dehydrogenase-like, 2-hydroxycarboxylate dehydrogenase family; Region: LDH_MDH_like; cl17195 1274814013674 NAD(P) binding site [chemical binding]; other site 1274814013675 LDH/MDH dimer interface [polypeptide binding]; other site 1274814013676 substrate binding site [chemical binding]; other site 1274814013677 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 1274814013678 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 1274814013679 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1274814013680 active site turn [active] 1274814013681 phosphorylation site [posttranslational modification] 1274814013682 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 1274814013683 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814013684 DNA-binding site [nucleotide binding]; DNA binding site 1274814013685 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 1274814013686 putative transporter; Validated; Region: PRK03818 1274814013687 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 1274814013688 TrkA-C domain; Region: TrkA_C; pfam02080 1274814013689 TrkA-C domain; Region: TrkA_C; pfam02080 1274814013690 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 1274814013691 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1274814013692 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1274814013693 putative dimer interface [polypeptide binding]; other site 1274814013694 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 1274814013695 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 1274814013696 putative dimer interface [polypeptide binding]; other site 1274814013697 hypothetical protein; Provisional; Region: PRK11616 1274814013698 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 1274814013699 putative oxidoreductase; Provisional; Region: PRK11445 1274814013700 hypothetical protein; Provisional; Region: PRK07236 1274814013701 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814013702 D-galactonate transporter; Region: 2A0114; TIGR00893 1274814013703 putative substrate translocation pore; other site 1274814013704 galactonate dehydratase; Provisional; Region: PRK14017 1274814013705 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 1274814013706 putative active site pocket [active] 1274814013707 putative metal binding site [ion binding]; other site 1274814013708 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 1274814013709 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 1274814013710 active site 1274814013711 intersubunit interface [polypeptide binding]; other site 1274814013712 catalytic residue [active] 1274814013713 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 1274814013714 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 1274814013715 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1274814013716 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814013717 DNA-binding site [nucleotide binding]; DNA binding site 1274814013718 FCD domain; Region: FCD; pfam07729 1274814013719 hypothetical protein; Provisional; Region: PRK10215 1274814013720 sugar phosphate phosphatase; Provisional; Region: PRK10513 1274814013721 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814013722 active site 1274814013723 motif I; other site 1274814013724 motif II; other site 1274814013725 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814013726 hypothetical protein; Provisional; Region: PRK11426 1274814013727 Protein of unknown function (DUF3521); Region: DUF3521; pfam12035 1274814013728 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 1274814013729 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 1274814013730 Mg2+ binding site [ion binding]; other site 1274814013731 G-X-G motif; other site 1274814013732 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 1274814013733 anchoring element; other site 1274814013734 dimer interface [polypeptide binding]; other site 1274814013735 ATP binding site [chemical binding]; other site 1274814013736 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 1274814013737 active site 1274814013738 putative metal-binding site [ion binding]; other site 1274814013739 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 1274814013740 recF protein; Region: recf; TIGR00611 1274814013741 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814013742 Walker A/P-loop; other site 1274814013743 ATP binding site [chemical binding]; other site 1274814013744 Q-loop/lid; other site 1274814013745 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 1274814013746 ABC transporter signature motif; other site 1274814013747 Walker B; other site 1274814013748 D-loop; other site 1274814013749 H-loop/switch region; other site 1274814013750 DNA polymerase III subunit beta; Validated; Region: PRK05643 1274814013751 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 1274814013752 putative DNA binding surface [nucleotide binding]; other site 1274814013753 dimer interface [polypeptide binding]; other site 1274814013754 beta-clamp/clamp loader binding surface; other site 1274814013755 beta-clamp/translesion DNA polymerase binding surface; other site 1274814013756 DnaA N-terminal domain; Region: DnaA_N; pfam11638 1274814013757 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 1274814013758 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814013759 Walker A motif; other site 1274814013760 ATP binding site [chemical binding]; other site 1274814013761 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 1274814013762 Walker B motif; other site 1274814013763 arginine finger; other site 1274814013764 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 1274814013765 DnaA box-binding interface [nucleotide binding]; other site 1274814013766 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399 1274814013767 ribonuclease P; Reviewed; Region: rnpA; PRK01732 1274814013768 hypothetical protein; Validated; Region: PRK00041 1274814013769 membrane protein insertase; Provisional; Region: PRK01318 1274814013770 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 1274814013771 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 1274814013772 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 1274814013773 trmE is a tRNA modification GTPase; Region: trmE; cd04164 1274814013774 G1 box; other site 1274814013775 GTP/Mg2+ binding site [chemical binding]; other site 1274814013776 Switch I region; other site 1274814013777 G2 box; other site 1274814013778 Switch II region; other site 1274814013779 G3 box; other site 1274814013780 G4 box; other site 1274814013781 G5 box; other site 1274814013782 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 1274814013783 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 1274814013784 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 1274814013785 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 1274814013786 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 1274814013787 catalytic residue [active] 1274814013788 tryptophan permease TnaB; Provisional; Region: PRK09664 1274814013789 aromatic amino acid transport protein; Region: araaP; TIGR00837 1274814013790 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 1274814013791 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814013792 putative substrate translocation pore; other site 1274814013793 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 1274814013794 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814013795 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 1274814013796 substrate binding pocket [chemical binding]; other site 1274814013797 dimerization interface [polypeptide binding]; other site 1274814013798 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 1274814013799 Predicted flavoprotein [General function prediction only]; Region: COG0431 1274814013800 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 1274814013801 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 1274814013802 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 1274814013803 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814013804 active site 1274814013805 motif I; other site 1274814013806 motif II; other site 1274814013807 putative inner membrane protein; Provisional; Region: PRK09823 1274814013808 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 1274814013809 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 1274814013810 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 1274814013811 active site 1274814013812 trimer interface [polypeptide binding]; other site 1274814013813 allosteric site; other site 1274814013814 active site lid [active] 1274814013815 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 1274814013816 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 1274814013817 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 1274814013818 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 1274814013819 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 1274814013820 trimer interface; other site 1274814013821 sugar binding site [chemical binding]; other site 1274814013822 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 1274814013823 beta-galactosidase; Region: BGL; TIGR03356 1274814013824 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 1274814013825 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 1274814013826 active site turn [active] 1274814013827 phosphorylation site [posttranslational modification] 1274814013828 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 1274814013829 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 1274814013830 HPr interaction site; other site 1274814013831 glycerol kinase (GK) interaction site [polypeptide binding]; other site 1274814013832 active site 1274814013833 phosphorylation site [posttranslational modification] 1274814013834 transcriptional antiterminator BglG; Provisional; Region: PRK09772 1274814013835 CAT RNA binding domain; Region: CAT_RBD; pfam03123 1274814013836 PRD domain; Region: PRD; pfam00874 1274814013837 PRD domain; Region: PRD; pfam00874 1274814013838 transcriptional regulator PhoU; Provisional; Region: PRK11115 1274814013839 PhoU domain; Region: PhoU; pfam01895 1274814013840 PhoU domain; Region: PhoU; pfam01895 1274814013841 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 1274814013842 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 1274814013843 Walker A/P-loop; other site 1274814013844 ATP binding site [chemical binding]; other site 1274814013845 Q-loop/lid; other site 1274814013846 ABC transporter signature motif; other site 1274814013847 Walker B; other site 1274814013848 D-loop; other site 1274814013849 H-loop/switch region; other site 1274814013850 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 1274814013851 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814013852 dimer interface [polypeptide binding]; other site 1274814013853 conserved gate region; other site 1274814013854 putative PBP binding loops; other site 1274814013855 ABC-ATPase subunit interface; other site 1274814013856 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 1274814013857 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 1274814013858 dimer interface [polypeptide binding]; other site 1274814013859 conserved gate region; other site 1274814013860 putative PBP binding loops; other site 1274814013861 ABC-ATPase subunit interface; other site 1274814013862 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 1274814013863 Fimbrial protein; Region: Fimbrial; cl01416 1274814013864 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 1274814013865 PapC N-terminal domain; Region: PapC_N; pfam13954 1274814013866 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 1274814013867 PapC C-terminal domain; Region: PapC_C; pfam13953 1274814013868 fimbrial chaperone protein; Provisional; Region: lfpB; PRK15290 1274814013869 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 1274814013870 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 1274814013871 fimbrial protein; Provisional; Region: lpfA; PRK15289 1274814013872 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 1274814013873 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 1274814013874 glutaminase active site [active] 1274814013875 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 1274814013876 dimer interface [polypeptide binding]; other site 1274814013877 active site 1274814013878 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 1274814013879 dimer interface [polypeptide binding]; other site 1274814013880 active site 1274814013881 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 1274814013882 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 1274814013883 Substrate binding site; other site 1274814013884 Mg++ binding site; other site 1274814013885 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 1274814013886 active site 1274814013887 substrate binding site [chemical binding]; other site 1274814013888 CoA binding site [chemical binding]; other site 1274814013889 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 1274814013890 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 1274814013891 gamma subunit interface [polypeptide binding]; other site 1274814013892 epsilon subunit interface [polypeptide binding]; other site 1274814013893 LBP interface [polypeptide binding]; other site 1274814013894 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 1274814013895 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1274814013896 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 1274814013897 alpha subunit interaction interface [polypeptide binding]; other site 1274814013898 Walker A motif; other site 1274814013899 ATP binding site [chemical binding]; other site 1274814013900 Walker B motif; other site 1274814013901 inhibitor binding site; inhibition site 1274814013902 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1274814013903 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 1274814013904 core domain interface [polypeptide binding]; other site 1274814013905 delta subunit interface [polypeptide binding]; other site 1274814013906 epsilon subunit interface [polypeptide binding]; other site 1274814013907 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 1274814013908 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 1274814013909 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 1274814013910 beta subunit interaction interface [polypeptide binding]; other site 1274814013911 Walker A motif; other site 1274814013912 ATP binding site [chemical binding]; other site 1274814013913 Walker B motif; other site 1274814013914 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 1274814013915 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 1274814013916 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 1274814013917 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 1274814013918 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 1274814013919 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 1274814013920 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 1274814013921 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 1274814013922 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 1274814013923 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 1274814013924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814013925 S-adenosylmethionine binding site [chemical binding]; other site 1274814013926 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 1274814013927 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 1274814013928 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 1274814013929 FMN-binding protein MioC; Provisional; Region: PRK09004 1274814013930 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 1274814013931 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 1274814013932 putative DNA binding site [nucleotide binding]; other site 1274814013933 putative Zn2+ binding site [ion binding]; other site 1274814013934 AsnC family; Region: AsnC_trans_reg; pfam01037 1274814013935 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 1274814013936 dimer interface [polypeptide binding]; other site 1274814013937 active site 1274814013938 hypothetical protein; Provisional; Region: yieM; PRK10997 1274814013939 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 1274814013940 metal ion-dependent adhesion site (MIDAS); other site 1274814013941 regulatory ATPase RavA; Provisional; Region: PRK13531 1274814013942 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814013943 Walker A motif; other site 1274814013944 ATP binding site [chemical binding]; other site 1274814013945 Walker B motif; other site 1274814013946 arginine finger; other site 1274814013947 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 1274814013948 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 1274814013949 potassium uptake protein; Region: kup; TIGR00794 1274814013950 D-ribose pyranase; Provisional; Region: PRK11797 1274814013951 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 1274814013952 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 1274814013953 Walker A/P-loop; other site 1274814013954 ATP binding site [chemical binding]; other site 1274814013955 Q-loop/lid; other site 1274814013956 ABC transporter signature motif; other site 1274814013957 Walker B; other site 1274814013958 D-loop; other site 1274814013959 H-loop/switch region; other site 1274814013960 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 1274814013961 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 1274814013962 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 1274814013963 TM-ABC transporter signature motif; other site 1274814013964 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 1274814013965 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 1274814013966 ligand binding site [chemical binding]; other site 1274814013967 dimerization interface [polypeptide binding]; other site 1274814013968 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 1274814013969 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 1274814013970 substrate binding site [chemical binding]; other site 1274814013971 dimer interface [polypeptide binding]; other site 1274814013972 ATP binding site [chemical binding]; other site 1274814013973 transcriptional repressor RbsR; Provisional; Region: PRK10423 1274814013974 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 1274814013975 DNA binding site [nucleotide binding] 1274814013976 domain linker motif; other site 1274814013977 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 1274814013978 dimerization interface [polypeptide binding]; other site 1274814013979 ligand binding site [chemical binding]; other site 1274814013980 putative transporter; Provisional; Region: PRK10504 1274814013981 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814013982 putative substrate translocation pore; other site 1274814013983 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 1274814013984 Transcriptional regulators [Transcription]; Region: FadR; COG2186 1274814013985 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 1274814013986 DNA-binding site [nucleotide binding]; DNA binding site 1274814013987 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 1274814013988 transcriptional regulator HdfR; Provisional; Region: PRK03601 1274814013989 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814013990 LysR substrate binding domain; Region: LysR_substrate; pfam03466 1274814013991 dimerization interface [polypeptide binding]; other site 1274814013992 hypothetical protein; Provisional; Region: PRK11027 1274814013993 putative ATP-dependent protease; Provisional; Region: PRK09862 1274814013994 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 1274814013995 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 1274814013996 Walker A motif; other site 1274814013997 ATP binding site [chemical binding]; other site 1274814013998 Walker B motif; other site 1274814013999 arginine finger; other site 1274814014000 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 1274814014001 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 1274814014002 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 1274814014003 PYR/PP interface [polypeptide binding]; other site 1274814014004 dimer interface [polypeptide binding]; other site 1274814014005 TPP binding site [chemical binding]; other site 1274814014006 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 1274814014007 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 1274814014008 TPP-binding site [chemical binding]; other site 1274814014009 dimer interface [polypeptide binding]; other site 1274814014010 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 1274814014011 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 1274814014012 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 1274814014013 homodimer interface [polypeptide binding]; other site 1274814014014 substrate-cofactor binding pocket; other site 1274814014015 catalytic residue [active] 1274814014016 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 1274814014017 threonine dehydratase; Reviewed; Region: PRK09224 1274814014018 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 1274814014019 tetramer interface [polypeptide binding]; other site 1274814014020 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814014021 catalytic residue [active] 1274814014022 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 1274814014023 putative Ile/Val binding site [chemical binding]; other site 1274814014024 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 1274814014025 putative Ile/Val binding site [chemical binding]; other site 1274814014026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814014027 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 1274814014028 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 1274814014029 putative dimerization interface [polypeptide binding]; other site 1274814014030 ketol-acid reductoisomerase; Validated; Region: PRK05225 1274814014031 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 1274814014032 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1274814014033 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 1274814014034 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 1274814014035 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 1274814014036 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3692 1274814014037 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 1274814014038 Part of AAA domain; Region: AAA_19; pfam13245 1274814014039 Family description; Region: UvrD_C_2; pfam13538 1274814014040 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 1274814014041 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 1274814014042 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 1274814014043 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 1274814014044 ATP binding site [chemical binding]; other site 1274814014045 Mg++ binding site [ion binding]; other site 1274814014046 motif III; other site 1274814014047 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1274814014048 nucleotide binding region [chemical binding]; other site 1274814014049 ATP-binding site [chemical binding]; other site 1274814014050 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 1274814014051 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 1274814014052 catalytic residues [active] 1274814014053 putative rho operon leader peptide; Provisional; Region: PRK09979 1274814014054 transcription termination factor Rho; Provisional; Region: rho; PRK09376 1274814014055 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 1274814014056 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 1274814014057 RNA binding site [nucleotide binding]; other site 1274814014058 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 1274814014059 multimer interface [polypeptide binding]; other site 1274814014060 Walker A motif; other site 1274814014061 ATP binding site [chemical binding]; other site 1274814014062 Walker B motif; other site 1274814014063 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 1274814014064 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 1274814014065 Mg++ binding site [ion binding]; other site 1274814014066 putative catalytic motif [active] 1274814014067 substrate binding site [chemical binding]; other site 1274814014068 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 1274814014069 Chain length determinant protein; Region: Wzz; pfam02706 1274814014070 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 1274814014071 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 1274814014072 active site 1274814014073 homodimer interface [polypeptide binding]; other site 1274814014074 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 1274814014075 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 1274814014076 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 1274814014077 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 1274814014078 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 1274814014079 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 1274814014080 NAD binding site [chemical binding]; other site 1274814014081 substrate binding site [chemical binding]; other site 1274814014082 homodimer interface [polypeptide binding]; other site 1274814014083 active site 1274814014084 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 1274814014085 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 1274814014086 substrate binding site; other site 1274814014087 tetramer interface; other site 1274814014088 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 1274814014089 Coenzyme A binding pocket [chemical binding]; other site 1274814014090 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 1274814014091 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 1274814014092 inhibitor-cofactor binding pocket; inhibition site 1274814014093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 1274814014094 catalytic residue [active] 1274814014095 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 1274814014096 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 1274814014097 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 1274814014098 putative common antigen polymerase; Provisional; Region: PRK02975 1274814014099 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 1274814014100 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 1274814014101 putative transport protein YifK; Provisional; Region: PRK10746 1274814014102 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 1274814014103 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 1274814014104 FeS/SAM binding site; other site 1274814014105 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 1274814014106 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 1274814014107 HemY protein N-terminus; Region: HemY_N; pfam07219 1274814014108 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 1274814014109 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 1274814014110 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 1274814014111 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 1274814014112 active site 1274814014113 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 1274814014114 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 1274814014115 domain interfaces; other site 1274814014116 active site 1274814014117 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 1274814014118 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 1274814014119 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 1274814014120 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 1274814014121 putative iron binding site [ion binding]; other site 1274814014122 hypothetical protein; Provisional; Region: PRK09807 1274814014123 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 1274814014124 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 1274814014125 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1274814014126 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 1274814014127 hypothetical protein; Provisional; Region: PRK10963 1274814014128 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 1274814014129 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 1274814014130 active site 1274814014131 DNA binding site [nucleotide binding] 1274814014132 Int/Topo IB signature motif; other site 1274814014133 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 1274814014134 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814014135 motif II; other site 1274814014136 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 1274814014137 Part of AAA domain; Region: AAA_19; pfam13245 1274814014138 Family description; Region: UvrD_C_2; pfam13538 1274814014139 Predicted periplasmic protein [Function unknown]; Region: COG3698 1274814014140 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 1274814014141 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 1274814014142 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 1274814014143 Cl binding site [ion binding]; other site 1274814014144 oligomer interface [polypeptide binding]; other site 1274814014145 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 1274814014146 hypothetical protein; Provisional; Region: PRK11371 1274814014147 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 1274814014148 EamA-like transporter family; Region: EamA; cl17759 1274814014149 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 1274814014150 CoenzymeA binding site [chemical binding]; other site 1274814014151 subunit interaction site [polypeptide binding]; other site 1274814014152 PHB binding site; other site 1274814014153 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 1274814014154 dimerization interface [polypeptide binding]; other site 1274814014155 substrate binding site [chemical binding]; other site 1274814014156 active site 1274814014157 calcium binding site [ion binding]; other site 1274814014158 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 1274814014159 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 1274814014160 ATP binding site [chemical binding]; other site 1274814014161 putative Mg++ binding site [ion binding]; other site 1274814014162 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 1274814014163 nucleotide binding region [chemical binding]; other site 1274814014164 ATP-binding site [chemical binding]; other site 1274814014165 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 1274814014166 Helicase and RNase D C-terminal; Region: HRDC; smart00341 1274814014167 threonine efflux system; Provisional; Region: PRK10229 1274814014168 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 1274814014169 lysophospholipase L2; Provisional; Region: PRK10749 1274814014170 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 1274814014171 putative hydrolase; Provisional; Region: PRK10976 1274814014172 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814014173 active site 1274814014174 motif I; other site 1274814014175 motif II; other site 1274814014176 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 1274814014177 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 1274814014178 EamA-like transporter family; Region: EamA; pfam00892 1274814014179 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 1274814014180 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 1274814014181 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 1274814014182 putative dimerization interface [polypeptide binding]; other site 1274814014183 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 1274814014184 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 1274814014185 THF binding site; other site 1274814014186 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 1274814014187 substrate binding site [chemical binding]; other site 1274814014188 THF binding site; other site 1274814014189 zinc-binding site [ion binding]; other site 1274814014190 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 1274814014191 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 1274814014192 uridine phosphorylase; Provisional; Region: PRK11178 1274814014193 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 1274814014194 DNA recombination protein RmuC; Provisional; Region: PRK10361 1274814014195 RmuC family; Region: RmuC; pfam02646 1274814014196 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 1274814014197 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 1274814014198 S-adenosylmethionine binding site [chemical binding]; other site 1274814014199 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 1274814014200 SCP-2 sterol transfer family; Region: SCP2; pfam02036 1274814014201 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 1274814014202 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 1274814014203 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 1274814014204 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 1274814014205 sec-independent translocase; Provisional; Region: PRK01770 1274814014206 sec-independent translocase; Provisional; Region: tatB; PRK00404 1274814014207 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 1274814014208 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 1274814014209 active site 1274814014210 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 1274814014211 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 1274814014212 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 1274814014213 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 1274814014214 FMN reductase; Validated; Region: fre; PRK08051 1274814014215 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 1274814014216 FAD binding pocket [chemical binding]; other site 1274814014217 FAD binding motif [chemical binding]; other site 1274814014218 phosphate binding motif [ion binding]; other site 1274814014219 beta-alpha-beta structure motif; other site 1274814014220 NAD binding pocket [chemical binding]; other site 1274814014221 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 1274814014222 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 1274814014223 dimer interface [polypeptide binding]; other site 1274814014224 active site 1274814014225 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 1274814014226 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 1274814014227 substrate binding site [chemical binding]; other site 1274814014228 oxyanion hole (OAH) forming residues; other site 1274814014229 trimer interface [polypeptide binding]; other site 1274814014230 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 1274814014231 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1274814014232 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 1274814014233 proline dipeptidase; Provisional; Region: PRK13607 1274814014234 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 1274814014235 active site 1274814014236 hypothetical protein; Provisional; Region: PRK11568 1274814014237 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 1274814014238 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 1274814014239 potassium transporter; Provisional; Region: PRK10750 1274814014240 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 1274814014241 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104