-- dump date 20140619_081333 -- class Genbank::misc_feature -- table misc_feature_note -- id note 481805000001 DnaA N-terminal domain; Region: DnaA_N; pfam11638 481805000002 chromosomal replication initiator protein DnaA; Region: DnaA; TIGR00362 481805000003 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805000004 Walker A motif; other site 481805000005 ATP binding site [chemical binding]; other site 481805000006 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 481805000007 Walker B motif; other site 481805000008 arginine finger; other site 481805000009 C-terminal domain of bacterial DnaA proteins. The DNA-binding C-terminal domain of DnaA contains a helix-turn-helix motif that specifically interacts with the DnaA box, a 9-mer motif that occurs repetitively in the replication origin oriC. Multiple...; Region: Bac_DnaA_C; cd06571 481805000010 DnaA box-binding interface [nucleotide binding]; other site 481805000011 DNA polymerase III subunit beta; Validated; Region: PRK05643 481805000012 Beta clamp domain. The beta subunit (processivity factor) of DNA polymerase III holoenzyme, refered to as the beta clamp, forms a ring shaped dimer that encircles dsDNA (sliding clamp) in bacteria. The beta-clamp is structurally similar to the trimeric...; Region: beta_clamp; cd00140 481805000013 putative DNA binding surface [nucleotide binding]; other site 481805000014 dimer interface [polypeptide binding]; other site 481805000015 beta-clamp/clamp loader binding surface; other site 481805000016 beta-clamp/translesion DNA polymerase binding surface; other site 481805000017 recF protein; Region: recf; TIGR00611 481805000018 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805000019 Walker A/P-loop; other site 481805000020 ATP binding site [chemical binding]; other site 481805000021 Q-loop/lid; other site 481805000022 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805000023 ABC transporter signature motif; other site 481805000024 Walker B; other site 481805000025 D-loop; other site 481805000026 H-loop/switch region; other site 481805000027 DNA gyrase subunit B; Provisional; Region: gyrB; PRK14939 481805000028 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805000029 Mg2+ binding site [ion binding]; other site 481805000030 G-X-G motif; other site 481805000031 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 481805000032 anchoring element; other site 481805000033 dimer interface [polypeptide binding]; other site 481805000034 ATP binding site [chemical binding]; other site 481805000035 TOPRIM_TopoIIA_GyrB: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in proteins of the type IIA family of DNA topoisomerases similar to the Escherichia coli GyrB subunit. TopoIIA enzymes cut both strands of the...; Region: TOPRIM_TopoIIA_GyrB; cd03366 481805000036 active site 481805000037 putative metal-binding site [ion binding]; other site 481805000038 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 481805000039 hypothetical protein; Provisional; Region: PRK11426 481805000040 sugar phosphate phosphatase; Provisional; Region: PRK10513 481805000041 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805000042 active site 481805000043 motif I; other site 481805000044 motif II; other site 481805000045 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805000046 hypothetical protein; Provisional; Region: PRK10215 481805000047 Transcriptional regulators [Transcription]; Region: FadR; COG2186 481805000048 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805000049 DNA-binding site [nucleotide binding]; DNA binding site 481805000050 FCD domain; Region: FCD; pfam07729 481805000051 2-keto-3-deoxy-galactonokinase [Carbohydrate transport and metabolism]; Region: DgoK; COG3734 481805000052 2-keto-3-deoxy-galactonokinase; Region: DGOK; pfam05035 481805000053 2-dehydro-3-deoxy-6-phosphogalactonate aldolase; Reviewed; Region: PRK09140 481805000054 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 481805000055 active site 481805000056 intersubunit interface [polypeptide binding]; other site 481805000057 catalytic residue [active] 481805000058 galactonate dehydratase; Provisional; Region: PRK14017 481805000059 D-galactonate dehydratase catalyses the dehydration of galactonate to 2-keto-3-deoxygalactnate (KDGal), as part of the D-galactonate nonphosphorolytic catabolic Entner-Doudoroff pathway. D-galactonate dehydratase belongs to the enolase superfamily of...; Region: D-galactonate_dehydratase; cd03325 481805000060 putative active site pocket [active] 481805000061 putative metal binding site [ion binding]; other site 481805000062 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805000063 D-galactonate transporter; Region: 2A0114; TIGR00893 481805000064 putative substrate translocation pore; other site 481805000065 putative oxidoreductase; Provisional; Region: PRK11445 481805000066 hypothetical protein; Provisional; Region: PRK07236 481805000067 Protein of unknown function (DUF3748); Region: DUF3748; pfam12566 481805000068 hypothetical protein; Provisional; Region: PRK11616 481805000069 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 481805000070 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 481805000071 putative dimer interface [polypeptide binding]; other site 481805000072 Molecular chaperone (small heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: IbpA; COG0071 481805000073 Alpha-crystallin domain (ACD) found in Escherichia coli inclusion body-associated proteins IbpA and IbpB, and similar proteins. IbpA and IbpB are 16 kDa small heat shock proteins (sHsps). sHsps are molecular chaperones that suppress protein aggregation...; Region: ACD_IbpA-B_like; cd06470 481805000074 putative dimer interface [polypeptide binding]; other site 481805000075 putative transporter; Validated; Region: PRK03818 481805000076 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 481805000077 TrkA-C domain; Region: TrkA_C; pfam02080 481805000078 TrkA-C domain; Region: TrkA_C; pfam02080 481805000079 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 481805000080 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 481805000081 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805000082 DNA-binding site [nucleotide binding]; DNA binding site 481805000083 The UbiC transcription regulator-associated (UTRA) domain is a conserved ligand-binding domain; Region: UTRA; smart00866 481805000084 PTS system, alpha-glucoside-specific IIBC component; Region: PTS-IIBC-alpha; TIGR02005 481805000085 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 481805000086 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 481805000087 active site turn [active] 481805000088 phosphorylation site [posttranslational modification] 481805000089 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 481805000090 Glycoside Hydrolases Family 4; GlvA- and pagL-like glycosidases; Region: GH4_GlvA_pagL_like; cd05298 481805000091 NAD binding site [chemical binding]; other site 481805000092 sugar binding site [chemical binding]; other site 481805000093 divalent metal binding site [ion binding]; other site 481805000094 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 481805000095 dimer interface [polypeptide binding]; other site 481805000096 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 481805000097 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG0675 481805000098 Probable transposase; Region: OrfB_IS605; pfam01385 481805000099 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 481805000100 Predicted membrane protein [Function unknown]; Region: COG2149 481805000101 Domain of unknown function (DUF202); Region: DUF202; pfam02656 481805000102 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 481805000103 multidrug resistance protein D; Provisional; Region: emrD; PRK11652 481805000104 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805000105 putative substrate translocation pore; other site 481805000106 acetolactate synthase catalytic subunit; Validated; Region: PRK08155 481805000107 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 481805000108 PYR/PP interface [polypeptide binding]; other site 481805000109 dimer interface [polypeptide binding]; other site 481805000110 TPP binding site [chemical binding]; other site 481805000111 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 481805000112 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 481805000113 TPP-binding site [chemical binding]; other site 481805000114 dimer interface [polypeptide binding]; other site 481805000115 Acetolactate synthase, small (regulatory) subunit [Amino acid transport and metabolism]; Region: IlvH; COG0440 481805000116 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 481805000117 putative valine binding site [chemical binding]; other site 481805000118 dimer interface [polypeptide binding]; other site 481805000119 DNA-binding transcriptional activator UhpA; Provisional; Region: PRK10360 481805000120 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805000121 active site 481805000122 phosphorylation site [posttranslational modification] 481805000123 intermolecular recognition site; other site 481805000124 dimerization interface [polypeptide binding]; other site 481805000125 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805000126 DNA binding residues [nucleotide binding] 481805000127 dimerization interface [polypeptide binding]; other site 481805000128 sensory histidine kinase UhpB; Provisional; Region: PRK11644 481805000129 MASE1; Region: MASE1; pfam05231 481805000130 Histidine kinase; Region: HisKA_3; pfam07730 481805000131 regulatory protein UhpC; Provisional; Region: PRK11663 481805000132 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805000133 putative substrate translocation pore; other site 481805000134 sugar phosphate antiporter; Reviewed; Region: uhpT; PRK09556 481805000135 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805000136 putative substrate translocation pore; other site 481805000137 cryptic adenine deaminase; Provisional; Region: PRK10027 481805000138 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 481805000139 Adenine deaminase (AdeC) directly deaminates adenine to form hypoxanthine. This reaction is part of one of the adenine salvage pathways, as well as the degradation pathway. It is important for adenine utilization as a purine, as well as a nitrogen source...; Region: AdeC; cd01295 481805000140 active site 481805000141 Adenine deaminase C-terminal domain; Region: Adenine_deam_C; pfam13382 481805000142 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 481805000143 Protein of unknown function (DUF1198); Region: DUF1198; pfam06711 481805000144 ribonucleoside transporter; Reviewed; Region: nepI; PRK10213 481805000145 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805000146 putative substrate translocation pore; other site 481805000147 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 481805000148 cytoplasmic membrane lipoprotein-28; Provisional; Region: PRK09861 481805000149 lipoprotein, YaeC family; Region: TIGR00363 481805000150 EamA-like transporter family; Region: EamA; pfam00892 481805000151 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 481805000152 EamA-like transporter family; Region: EamA; pfam00892 481805000153 sugar efflux transporter; Region: 2A0120; TIGR00899 481805000154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805000155 putative substrate translocation pore; other site 481805000156 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 481805000157 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 481805000158 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 481805000159 active site 481805000160 metal binding site [ion binding]; metal-binding site 481805000161 interdomain interaction site; other site 481805000162 D5 N terminal like; Region: D5_N; smart00885 481805000163 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 481805000164 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 481805000165 Ash protein family; Region: Phage_ASH; pfam10554 481805000166 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 481805000167 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 481805000168 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 481805000169 integrase; Provisional; Region: PRK09692 481805000170 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 481805000171 active site 481805000172 Int/Topo IB signature motif; other site 481805000173 putative transporter; Provisional; Region: PRK11462 481805000174 Na+/melibiose symporter and related transporters [Carbohydrate transport and metabolism]; Region: MelB; COG2211 481805000175 putative alpha-glucosidase; Provisional; Region: PRK10658 481805000176 Galactose mutarotase-like; Region: Gal_mutarotas_2; pfam13802 481805000177 YicI alpha-xylosidase is a glycosyl hydrolase family 31 (GH31) enzyme that catalyzes the release of an alpha-xylosyl residue from the non-reducing end of alpha-xyloside substrates such as alpha-xylosyl fluoride and isoprimeverose. YicI forms a...; Region: GH31_xylosidase_YicI; cd06593 481805000178 active site 481805000179 homotrimer interface [polypeptide binding]; other site 481805000180 catalytic site [active] 481805000181 homohexamer (dimer of homotrimers) interface [polypeptide binding]; other site 481805000182 AsmA family; Region: AsmA; pfam05170 481805000183 Domain of Unknown Function (DUF748); Region: DUF748; pfam05359 481805000184 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 481805000185 Xanthine/uracil permeases [Nucleotide transport and metabolism]; Region: UraA; COG2233 481805000186 sodium--glutamate symport carrier (gltS); Region: gltS; TIGR00210 481805000187 ATP-dependent DNA helicase RecG; Provisional; Region: PRK10917 481805000188 RecG_wedge_OBF: A subfamily of OB folds corresponding to the OB fold found in the N-terminal (wedge) domain of Escherichia coli RecG. RecG is a branched-DNA-specific helicase, which catalyzes the interconversion of a DNA replication fork to a...; Region: RecG_wedge_OBF; cd04488 481805000189 generic binding surface II; other site 481805000190 ssDNA binding site; other site 481805000191 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481805000192 ATP binding site [chemical binding]; other site 481805000193 putative Mg++ binding site [ion binding]; other site 481805000194 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805000195 nucleotide binding region [chemical binding]; other site 481805000196 ATP-binding site [chemical binding]; other site 481805000197 tRNA guanosine-2'-O-methyltransferase; Provisional; Region: PRK11081 481805000198 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 481805000199 SpoU, rRNA methylase, C-terminal; Region: SpoU_methylas_C; pfam12105 481805000200 bifunctional (p)ppGpp synthetase II/ guanosine-3',5'-bis pyrophosphate 3'-pyrophosphohydrolase; Provisional; Region: PRK11092 481805000201 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481805000202 Zn2+ binding site [ion binding]; other site 481805000203 Mg2+ binding site [ion binding]; other site 481805000204 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 481805000205 synthetase active site [active] 481805000206 NTP binding site [chemical binding]; other site 481805000207 metal binding site [ion binding]; metal-binding site 481805000208 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 481805000209 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 481805000210 DNA-directed RNA polymerase, omega subunit; Region: rpoZ; TIGR00690 481805000211 Guanylate kinase [Nucleotide transport and metabolism]; Region: Gmk; COG0194 481805000212 Guanosine monophosphate kinase (GMPK, EC 2.7.4.8), also known as guanylate kinase (GKase), catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to guanosine monophosphate (GMP) to yield adenosine diphosphate (ADP) and guanosine...; Region: GMPK; cd00071 481805000213 catalytic site [active] 481805000214 G-X2-G-X-G-K; other site 481805000215 NAD-dependent DNA ligase LigB; Reviewed; Region: ligB; PRK08097 481805000216 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 481805000217 nucleotide binding pocket [chemical binding]; other site 481805000218 K-X-D-G motif; other site 481805000219 catalytic site [active] 481805000220 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 481805000221 Predicted membrane protein [Function unknown]; Region: COG2860 481805000222 UPF0126 domain; Region: UPF0126; pfam03458 481805000223 UPF0126 domain; Region: UPF0126; pfam03458 481805000224 DNA-damage-inducible protein D; Provisional; Region: dinD; PRK11525 481805000225 BRO family, N-terminal domain; Region: Bro-N; pfam02498 481805000226 hypothetical protein; Provisional; Region: PRK11820 481805000227 YicC-like family, N-terminal region; Region: YicC_N; pfam03755 481805000228 Domain of unknown function (DUF1732); Region: DUF1732; pfam08340 481805000229 ribonuclease PH; Reviewed; Region: rph; PRK00173 481805000230 Ribonuclease PH; Region: RNase_PH_bact; cd11362 481805000231 hexamer interface [polypeptide binding]; other site 481805000232 active site 481805000233 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481805000234 active site 481805000235 division inhibitor protein; Provisional; Region: slmA; PRK09480 481805000236 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481805000237 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 481805000238 trimer interface [polypeptide binding]; other site 481805000239 active site 481805000240 bifunctional phosphopantothenoylcysteine decarboxylase/phosphopantothenate synthase; Validated; Region: PRK05579 481805000241 Flavoprotein; Region: Flavoprotein; pfam02441 481805000242 DNA / pantothenate metabolism flavoprotein; Region: DFP; pfam04127 481805000243 hypothetical protein; Reviewed; Region: PRK00024 481805000244 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 481805000245 MPN+ (JAMM) motif; other site 481805000246 Zinc-binding site [ion binding]; other site 481805000247 50S ribosomal protein L28; Reviewed; Region: rpmB; PRK00359 481805000248 50S ribosomal protein L33; Validated; Region: rpmG; PRK00595 481805000249 formamidopyrimidine/5-formyluracil/ 5-hydroxymethyluracil DNA glycosylase; Validated; Region: PRK01103 481805000250 N-terminal domain of Escherichia coli Fpg1/MutM and related bacterial DNA glycosylases; Region: EcFpg-like_N; cd08966 481805000251 DNA binding site [nucleotide binding] 481805000252 catalytic residue [active] 481805000253 H2TH interface [polypeptide binding]; other site 481805000254 putative catalytic residues [active] 481805000255 turnover-facilitating residue; other site 481805000256 intercalation triad [nucleotide binding]; other site 481805000257 8OG recognition residue [nucleotide binding]; other site 481805000258 putative reading head residues; other site 481805000259 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 481805000260 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 481805000261 phosphopantetheine adenylyltransferase; Provisional; Region: coaD; PRK00168 481805000262 Phosphopantetheine adenylyltransferase; Region: PPAT; cd02163 481805000263 active site 481805000264 (T/H)XGH motif; other site 481805000265 3-deoxy-D-manno-octulosonic-acid transferase; Reviewed; Region: PRK05749 481805000266 3-Deoxy-D-manno-octulosonic-acid transferase (kdotransferase); Region: Glycos_transf_N; pfam04413 481805000267 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 481805000268 lipopolysaccharide core biosynthesis protein; Provisional; Region: PRK10422 481805000269 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 481805000270 putative active site [active] 481805000271 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 481805000272 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 481805000273 lipopolysaccharide core heptose(I) kinase RfaP; Provisional; Region: PRK15123 481805000274 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 481805000275 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 481805000276 Ligand binding site; other site 481805000277 metal-binding site 481805000278 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 481805000279 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 481805000280 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 481805000281 Ligand binding site; other site 481805000282 metal-binding site 481805000283 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 481805000284 Lipopolysaccharide core biosynthesis protein (WaaY); Region: WaaY; pfam06176 481805000285 lipopolysaccharide 1,3-galactosyltransferase; Provisional; Region: PRK15171 481805000286 A4GalT_like proteins catalyze the addition of galactose or glucose residues to the lipooligosaccharide (LOS) or lipopolysaccharide (LPS) of the bacterial cell surface; Region: GT8_A4GalT_like; cd04194 481805000287 Ligand binding site; other site 481805000288 metal-binding site 481805000289 Glycosyl transferase family 8 C-terminal; Region: Glyco_transf_8C; pfam08437 481805000290 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 481805000291 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 481805000292 active site 481805000293 O-Antigen ligase; Region: Wzy_C; pfam04932 481805000294 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 481805000295 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 481805000296 putative active site [active] 481805000297 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 481805000298 Lipopolysaccharide heptosyltransferase is involved in the biosynthesis of lipooligosaccharide (LOS). Lipopolysaccharide (LPS) is a major component of the outer membrane of gram-negative bacteria. LPS heptosyltransferase transfers heptose molecules from...; Region: GT1_LPS_heptosyltransferase; cd03789 481805000299 putative active site [active] 481805000300 ADP-L-glycero-D-mannoheptose 6-epimerase (GME), extended (e) SDRs; Region: ADP_GME_SDR_e; cd05248 481805000301 ADP-L-glycero-D-mannoheptose-6-epimerase; Provisional; Region: rfaD; PRK11150 481805000302 NADP binding site [chemical binding]; other site 481805000303 homopentamer interface [polypeptide binding]; other site 481805000304 substrate binding site [chemical binding]; other site 481805000305 active site 481805000306 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 481805000307 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 481805000308 substrate-cofactor binding pocket; other site 481805000309 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805000310 catalytic residue [active] 481805000311 L-threonine 3-dehydrogenase; Validated; Region: tdh; PRK05396 481805000312 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 481805000313 NAD(P) binding site [chemical binding]; other site 481805000314 putative glycosyl transferase; Provisional; Region: PRK10073 481805000315 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 481805000316 active site 481805000317 Putative catalytic domain of family 2 polysaccharide deacetylases (DACs) from bacteria; Region: CE4_DAC2; cd10936 481805000318 NodB motif; other site 481805000319 putative active site [active] 481805000320 putative catalytic site [active] 481805000321 Zn binding site [ion binding]; other site 481805000322 AmiB activator; Provisional; Region: PRK11637 481805000323 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 481805000324 Peptidase family M23; Region: Peptidase_M23; pfam01551 481805000325 phosphoglyceromutase; Provisional; Region: PRK05434 481805000326 2,3-bisphosphoglycerate-independent phosphoglycerate mutase; Region: pgm_bpd_ind; TIGR01307 481805000327 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 481805000328 active site residue [active] 481805000329 Glutaredoxin (GRX) family, GRX bacterial class 1 and 3 (b_1_3)-like subfamily; composed of bacterial GRXs, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the...; Region: GRX_GRXb_1_3_like; cd03418 481805000330 GSH binding site [chemical binding]; other site 481805000331 catalytic residues [active] 481805000332 Preprotein translocase subunit SecB. SecB is a cytoplasmic component of the multisubunit membrane-bound enzyme termed Sec protein translocase, which is the main constituent of the General Secretory (type II) Pathway involved in translocation of nascent...; Region: Translocase_SecB; cd00557 481805000333 SecA binding site; other site 481805000334 Preprotein binding site; other site 481805000335 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase; Validated; Region: gpsA; PRK00094 481805000336 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 481805000337 NAD-dependent glycerol-3-phosphate dehydrogenase C-terminus; Region: NAD_Gly3P_dh_C; pfam07479 481805000338 serine acetyltransferase; Provisional; Region: cysE; PRK11132 481805000339 Serine acetyltransferase, N-terminal; Region: SATase_N; pfam06426 481805000340 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 481805000341 trimer interface [polypeptide binding]; other site 481805000342 active site 481805000343 substrate binding site [chemical binding]; other site 481805000344 CoA binding site [chemical binding]; other site 481805000345 putative rRNA methylase; Provisional; Region: PRK10358 481805000346 L-lactate dehydrogenase; Provisional; Region: lldD; PRK11197 481805000347 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 481805000348 phosphate binding site [ion binding]; other site 481805000349 DNA-binding transcriptional repressor LldR; Provisional; Region: PRK10421 481805000350 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805000351 DNA-binding site [nucleotide binding]; DNA binding site 481805000352 FCD domain; Region: FCD; pfam07729 481805000353 L-lactate permease; Provisional; Region: PRK10420 481805000354 glycolate transporter; Provisional; Region: PRK09695 481805000355 Protein of unknown function (DUF3251); Region: DUF3251; cl08186 481805000356 hypothetical protein; Provisional; Region: PRK11020 481805000357 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 481805000358 mannitol repressor protein; Provisional; Region: mtlR; PRK11001 481805000359 mannitol-1-phosphate 5-dehydrogenase; Provisional; Region: PRK02318 481805000360 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 481805000361 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 481805000362 PTS system mannitol-specific transporter subunit IICBA; Provisional; Region: PRK15083 481805000363 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 481805000364 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 481805000365 active site 481805000366 P-loop; other site 481805000367 phosphorylation site [posttranslational modification] 481805000368 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481805000369 active site 481805000370 phosphorylation site [posttranslational modification] 481805000371 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 481805000372 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 481805000373 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481805000374 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805000375 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 481805000376 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805000377 RHS protein; Region: RHS; pfam03527 481805000378 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 481805000379 putative lyase; Provisional; Region: PRK09687 481805000380 PAAR motif; Region: PAAR_motif; cl15808 481805000381 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805000382 RHS Repeat; Region: RHS_repeat; pfam05593 481805000383 RHS Repeat; Region: RHS_repeat; pfam05593 481805000384 RHS Repeat; Region: RHS_repeat; pfam05593 481805000385 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805000386 RHS Repeat; Region: RHS_repeat; pfam05593 481805000387 RHS Repeat; Region: RHS_repeat; pfam05593 481805000388 RHS protein; Region: RHS; pfam03527 481805000389 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 481805000390 putative glutathione S-transferase; Provisional; Region: PRK10357 481805000391 GST_N family, unknown subfamily 3; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_3; cd03049 481805000392 putative C-terminal domain interface [polypeptide binding]; other site 481805000393 putative GSH binding site (G-site) [chemical binding]; other site 481805000394 putative dimer interface [polypeptide binding]; other site 481805000395 C-terminal, alpha helical domain of an unknown subfamily 6 of Glutathione S-transferases; Region: GST_C_6; cd03205 481805000396 dimer interface [polypeptide binding]; other site 481805000397 N-terminal domain interface [polypeptide binding]; other site 481805000398 putative substrate binding pocket (H-site) [chemical binding]; other site 481805000399 selenocysteine synthase; Provisional; Region: PRK04311 481805000400 Selenocysteine synthase N terminal; Region: Se-cys_synth_N; pfam12390 481805000401 Selenocysteine synthase [seryl-tRNASer selenium transferase] [Amino acid transport and metabolism]; Region: SelA; COG1921 481805000402 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 481805000403 catalytic residue [active] 481805000404 selenocysteinyl-tRNA-specific translation factor; Provisional; Region: PRK10512 481805000405 SelB, the dedicated elongation factor for delivery of selenocysteinyl-tRNA to the ribosome; Region: SelB; cd04171 481805000406 G1 box; other site 481805000407 putative GEF interaction site [polypeptide binding]; other site 481805000408 GTP/Mg2+ binding site [chemical binding]; other site 481805000409 Switch I region; other site 481805000410 G2 box; other site 481805000411 G3 box; other site 481805000412 Switch II region; other site 481805000413 G4 box; other site 481805000414 G5 box; other site 481805000415 selB_II: this subfamily represents the domain of elongation factor SelB, homologous to domain II of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several...; Region: selB_II; cd03696 481805000416 This family represents the domain of elongation factor SelB, homologous to domain III of EF-Tu. SelB may function by replacing EF-Tu. In prokaryotes, the incorporation of selenocysteine as the 21st amino acid, encoded by TGA, requires several elements:...; Region: selB_III; cd04094 481805000417 Elongation factor SelB, winged helix; Region: SelB-wing_2; pfam09106 481805000418 Elongation factor SelB, winged helix; Region: SelB-wing_3; pfam09107 481805000419 putative alcohol dehydrogenase; Provisional; Region: PRK09860 481805000420 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 481805000421 dimer interface [polypeptide binding]; other site 481805000422 active site 481805000423 metal binding site [ion binding]; metal-binding site 481805000424 Ralstonia eutrophus NAD+-dependent acetaldehyde dehydrogenase II-like; Region: ALDH_ACDHII-AcoD; cd07116 481805000425 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 481805000426 NAD(P) binding site [chemical binding]; other site 481805000427 catalytic residues [active] 481805000428 Protein of unknown function (DUF3302); Region: DUF3302; pfam11742 481805000429 FlxA-like protein; Region: FlxA; pfam14282 481805000430 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 481805000431 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481805000432 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805000433 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481805000434 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805000435 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481805000436 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 481805000437 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 481805000438 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 481805000439 intersubunit interface [polypeptide binding]; other site 481805000440 active site 481805000441 Zn2+ binding site [ion binding]; other site 481805000442 putative L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13210 481805000443 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 481805000444 AP (apurinic/apyrimidinic) site pocket; other site 481805000445 DNA interaction; other site 481805000446 Metal-binding active site; metal-binding site 481805000447 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 481805000448 active site 481805000449 dimer interface [polypeptide binding]; other site 481805000450 magnesium binding site [ion binding]; other site 481805000451 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 481805000452 L-xylulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_L-XK; cd07802 481805000453 putative N- and C-terminal domain interface [polypeptide binding]; other site 481805000454 putative active site [active] 481805000455 MgATP binding site [chemical binding]; other site 481805000456 catalytic site [active] 481805000457 metal binding site [ion binding]; metal-binding site 481805000458 putative xylulose binding site [chemical binding]; other site 481805000459 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 481805000460 tripartite ATP-independent periplasmic transporter solute receptor, DctP family; Region: dctP; TIGR00787 481805000461 L-dehydroascorbate transporter large permease subunit; Provisional; Region: PRK15060 481805000462 DctM-like transporters; Region: DctM; pfam06808 481805000463 uncharacterized protein, YhcH/YjgK/YiaL family; Region: TIGR00022 481805000464 2,3-diketo-L-gulonate reductase; Provisional; Region: PRK13260 481805000465 Transcriptional regulator [Transcription]; Region: IclR; COG1414 481805000466 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 481805000467 Bacterial transcriptional regulator; Region: IclR; pfam01614 481805000468 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 481805000469 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 481805000470 valine--pyruvate transaminase; Provisional; Region: avtA; PRK09440 481805000471 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481805000472 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805000473 homodimer interface [polypeptide binding]; other site 481805000474 catalytic residue [active] 481805000475 alpha-amylase; Reviewed; Region: malS; PRK09505 481805000476 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 481805000477 active site 481805000478 catalytic site [active] 481805000479 hypothetical protein; Provisional; Region: PRK10356 481805000480 Uncharacterized FlgJ-related protein [General function prediction only]; Region: Bax; COG2992 481805000481 Ligand-binding domain of DNA transcription repressor specific for xylose (XylR); Region: PBP1_XylR; cd01543 481805000482 putative dimerization interface [polypeptide binding]; other site 481805000483 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481805000484 putative ligand binding site [chemical binding]; other site 481805000485 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805000486 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481805000487 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805000488 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481805000489 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481805000490 TM-ABC transporter signature motif; other site 481805000491 xylose transporter ATP-binding subunit; Provisional; Region: PRK13549 481805000492 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 481805000493 Walker A/P-loop; other site 481805000494 ATP binding site [chemical binding]; other site 481805000495 Q-loop/lid; other site 481805000496 ABC transporter signature motif; other site 481805000497 Walker B; other site 481805000498 D-loop; other site 481805000499 H-loop/switch region; other site 481805000500 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481805000501 D-xylose transporter subunit XylF; Provisional; Region: xylF; PRK10355 481805000502 Periplasmic xylose-binding component of the ABC-type transport systems that belong to a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_xylose_binding; cd01538 481805000503 putative ligand binding site [chemical binding]; other site 481805000504 xylose isomerase; Provisional; Region: PRK05474 481805000505 xylose isomerase; Region: xylose_isom_A; TIGR02630 481805000506 xylulokinase; Provisional; Region: PRK15027 481805000507 Escherichia coli xylulokinase-like D-xylulose kinases; a subgroup of the FGGY family of carbohydrate kinases; Region: FGGY_D-XK_EcXK-like; cd07808 481805000508 N- and C-terminal domain interface [polypeptide binding]; other site 481805000509 active site 481805000510 MgATP binding site [chemical binding]; other site 481805000511 catalytic site [active] 481805000512 metal binding site [ion binding]; metal-binding site 481805000513 xylulose binding site [chemical binding]; other site 481805000514 homodimer interface [polypeptide binding]; other site 481805000515 hypothetical protein; Provisional; Region: PRK11403 481805000516 yiaA/B two helix domain; Region: YiaAB; pfam05360 481805000517 hypothetical protein; Provisional; Region: PRK11383 481805000518 yiaA/B two helix domain; Region: YiaAB; pfam05360 481805000519 yiaA/B two helix domain; Region: YiaAB; pfam05360 481805000520 Predicted O-acyltransferase [General function prediction only]; Region: COG3274 481805000521 Acyltransferase family; Region: Acyl_transf_3; pfam01757 481805000522 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 481805000523 YsaB-like lipoprotein; Region: YsaB; pfam13983 481805000524 Class II Glycyl-tRNA synthetase (GlyRS) alpha subunit core catalytic domain. GlyRS functions as a homodimer in eukaryotes, archaea and some bacteria and as a heterotetramer in the remainder of prokaryotes and in arabidopsis. It is responsible for the...; Region: GlyRS_alpha_core; cd00733 481805000525 dimer interface [polypeptide binding]; other site 481805000526 motif 1; other site 481805000527 active site 481805000528 motif 2; other site 481805000529 motif 3; other site 481805000530 glycyl-tRNA synthetase, tetrameric type, beta subunit; Region: glyS; TIGR00211 481805000531 DALR anticodon binding domain; Region: DALR_1; pfam05746 481805000532 anticodon binding site; other site 481805000533 tRNA binding surface [nucleotide binding]; other site 481805000534 putative transposase OrfB; Reviewed; Region: PHA02517 481805000535 HTH-like domain; Region: HTH_21; pfam13276 481805000536 Integrase core domain; Region: rve; pfam00665 481805000537 Integrase core domain; Region: rve_2; pfam13333 481805000538 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 481805000539 Transposase; Region: HTH_Tnp_1; pfam01527 481805000540 small toxic polypeptide; Provisional; Region: PRK09759 481805000541 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 481805000542 DNA-binding site [nucleotide binding]; DNA binding site 481805000543 RNA-binding motif; other site 481805000544 Predicted transcriptional regulator [Transcription]; Region: COG2944 481805000545 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805000546 non-specific DNA binding site [nucleotide binding]; other site 481805000547 salt bridge; other site 481805000548 sequence-specific DNA binding site [nucleotide binding]; other site 481805000549 Protein of unknown function (DUF3053); Region: DUF3053; pfam11254 481805000550 bifunctional glyoxylate/hydroxypyruvate reductase B; Provisional; Region: PRK15409 481805000551 D-glycerate dehydrogenase/hydroxypyruvate reductase (GDH); Region: GDH; cd05301 481805000552 dimerization interface [polypeptide binding]; other site 481805000553 ligand binding site [chemical binding]; other site 481805000554 NADP binding site [chemical binding]; other site 481805000555 catalytic site [active] 481805000556 putative outer membrane lipoprotein; Provisional; Region: PRK10510 481805000557 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 481805000558 ligand binding site [chemical binding]; other site 481805000559 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 481805000560 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 481805000561 molybdopterin cofactor binding site [chemical binding]; other site 481805000562 substrate binding site [chemical binding]; other site 481805000563 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 481805000564 molybdopterin cofactor binding site; other site 481805000565 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 481805000566 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481805000567 Coenzyme A binding pocket [chemical binding]; other site 481805000568 3-methyl-adenine DNA glycosylase I; Provisional; Region: PRK10353 481805000569 Autotransporter protein or domain, integral membrane beta-barrel involved in protein secretion [Cell motility and secretion]; Region: COG5571 481805000570 oxalate/formate antiporter family transporter; Region: 2A0111; TIGR00890 481805000571 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805000572 putative substrate translocation pore; other site 481805000573 phosphoethanolamine transferase; Provisional; Region: PRK11560 481805000574 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 481805000575 Sulfatase; Region: Sulfatase; pfam00884 481805000576 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 481805000577 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 481805000578 peptide binding site [polypeptide binding]; other site 481805000579 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 481805000580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805000581 dimer interface [polypeptide binding]; other site 481805000582 conserved gate region; other site 481805000583 putative PBP binding loops; other site 481805000584 ABC-ATPase subunit interface; other site 481805000585 dipeptide transporter; Provisional; Region: PRK10913 481805000586 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 481805000587 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805000588 dimer interface [polypeptide binding]; other site 481805000589 conserved gate region; other site 481805000590 putative PBP binding loops; other site 481805000591 ABC-ATPase subunit interface; other site 481805000592 dipeptide transporter ATP-binding subunit; Provisional; Region: dppD; PRK11022 481805000593 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805000594 Walker A/P-loop; other site 481805000595 ATP binding site [chemical binding]; other site 481805000596 Q-loop/lid; other site 481805000597 ABC transporter signature motif; other site 481805000598 Walker B; other site 481805000599 D-loop; other site 481805000600 H-loop/switch region; other site 481805000601 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481805000602 dipeptide transporter ATP-binding subunit; Provisional; Region: dppF; PRK11308 481805000603 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805000604 Walker A/P-loop; other site 481805000605 ATP binding site [chemical binding]; other site 481805000606 Q-loop/lid; other site 481805000607 ABC transporter signature motif; other site 481805000608 Walker B; other site 481805000609 D-loop; other site 481805000610 H-loop/switch region; other site 481805000611 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481805000612 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 481805000613 serine transporter; Region: stp; TIGR00814 481805000614 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 481805000615 Protein of unknown function (DUF3260); Region: DUF3260; pfam11658 481805000616 celllulose biosynthesis operon protein BcsF/YhjT; Region: cellullose_BcsF; TIGR03493 481805000617 cellulose biosynthesis protein BcsE; Provisional; Region: PRK15045 481805000618 Protein of unknown function (DUF2819); Region: DUF2819; pfam10995 481805000619 Protein of unknown function (DUF2629); Region: DUF2629; pfam10945 481805000620 cell division protein; Provisional; Region: PRK10037 481805000621 cellulose synthase catalytic subunit; Provisional; Region: bcsA; PRK11498 481805000622 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 481805000623 CESA_CelA_like are involved in the elongation of the glucan chain of cellulose; Region: CESA_CelA_like; cd06421 481805000624 DXD motif; other site 481805000625 PilZ domain; Region: PilZ; pfam07238 481805000626 cellulose synthase regulator protein; Provisional; Region: PRK11114 481805000627 endo-1,4-D-glucanase; Provisional; Region: PRK11097 481805000628 cellulose synthase subunit BcsC; Provisional; Region: PRK11447 481805000629 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481805000630 binding surface 481805000631 TPR motif; other site 481805000632 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481805000633 binding surface 481805000634 TPR motif; other site 481805000635 Cellulose synthase operon protein C C-terminus (BCSC_C); Region: BCSC_C; pfam05420 481805000636 putative diguanylate cyclase; Provisional; Region: PRK13561 481805000637 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805000638 metal binding site [ion binding]; metal-binding site 481805000639 active site 481805000640 I-site; other site 481805000641 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805000642 C4-dicarboxylate transporter DctA; Reviewed; Region: PRK01663 481805000643 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 481805000644 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 481805000645 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 481805000646 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 481805000647 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 481805000648 substrate binding site [chemical binding]; other site 481805000649 ATP binding site [chemical binding]; other site 481805000650 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805000651 Uncharacterized protein involved in outer membrane biogenesis [Cell envelope biogenesis, outer membrane]; Region: AsmA; COG2982 481805000652 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 481805000653 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805000654 metabolite-proton symporter; Region: 2A0106; TIGR00883 481805000655 putative substrate translocation pore; other site 481805000656 inner membrane protein YhjD; Region: TIGR00766 481805000657 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481805000658 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805000659 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_3; cd08472 481805000660 putative effector binding pocket; other site 481805000661 putative dimerization interface [polypeptide binding]; other site 481805000662 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481805000663 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805000664 DNA binding residues [nucleotide binding] 481805000665 dimerization interface [polypeptide binding]; other site 481805000666 trehalase; Provisional; Region: treF; PRK13270 481805000667 Trehalase; Region: Trehalase; pfam01204 481805000668 Haem-binding domain; Region: Haem_bd; pfam14376 481805000669 Cytochrome c peroxidase [Inorganic ion transport and metabolism]; Region: MauG; COG1858 481805000670 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 481805000671 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805000672 catalytic residue [active] 481805000673 DNA-binding transcriptional regulator GadX; Provisional; Region: PRK09978 481805000674 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805000675 transcriptional regulator YdeO; Provisional; Region: PRK09940 481805000676 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805000677 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 481805000678 Protein export membrane protein; Region: SecD_SecF; cl14618 481805000679 multidrug efflux system protein MdtE; Provisional; Region: PRK09859 481805000680 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481805000681 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805000682 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 481805000683 pyruvate kinase; Provisional; Region: PRK05826 481805000684 acid-resistance membrane protein; Provisional; Region: PRK10209 481805000685 Uncharacterized conserved protein [Function unknown]; Region: HdeD; COG3247 481805000686 acid-resistance protein; Provisional; Region: PRK10208 481805000687 acid-resistance protein; Provisional; Region: hdeB; PRK11566 481805000688 putative Mg(2+) transport ATPase; Provisional; Region: PRK09977 481805000689 MgtC family; Region: MgtC; pfam02308 481805000690 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481805000691 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805000692 DNA binding residues [nucleotide binding] 481805000693 dimerization interface [polypeptide binding]; other site 481805000694 outer membrane lipoprotein, Slp family; Region: slp; TIGR00752 481805000695 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 481805000696 ArsC family; Region: ArsC; pfam03960 481805000697 catalytic residues [active] 481805000698 arsenical pump membrane protein; Provisional; Region: PRK15445 481805000699 Anion permease ArsB. These permeases have been shown to export arsenate and antimonite in eubacteria and archaea. A typical ArsB permease contains 8-13 transmembrane helices and can function either independently as a chemiosmotic transporter or as a...; Region: ArsB_permease; cd01118 481805000700 transmembrane helices; other site 481805000701 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481805000702 dimerization interface [polypeptide binding]; other site 481805000703 putative DNA binding site [nucleotide binding]; other site 481805000704 putative Zn2+ binding site [ion binding]; other site 481805000705 glutathione reductase; Validated; Region: PRK06116 481805000706 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481805000707 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805000708 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 481805000709 Protein involved in catabolism of external DNA [General function prediction only]; Region: ComJ; COG2961 481805000710 oligopeptidase A; Provisional; Region: PRK10911 481805000711 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 481805000712 active site 481805000713 Zn binding site [ion binding]; other site 481805000714 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805000715 S-adenosylmethionine binding site [chemical binding]; other site 481805000716 dipeptide/tripeptide permease B; Provisional; Region: PRK10207 481805000717 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805000718 POT family; Region: PTR2; pfam00854 481805000719 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 481805000720 Ligand Binding Site [chemical binding]; other site 481805000721 universal stress protein UspB; Provisional; Region: PRK04960 481805000722 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 481805000723 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 481805000724 Predicted flavoproteins [General function prediction only]; Region: COG2081 481805000725 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481805000726 Protein of unknown function (DUF2776); Region: DUF2776; pfam10951 481805000727 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 481805000728 Domain of unknown function (DUF4049); Region: DUF4049; pfam13258 481805000729 HlyD family secretion protein; Region: HlyD; pfam00529 481805000730 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481805000731 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805000732 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481805000733 ATPase components of various ABC-type transport systems, contain duplicated ATPase [General function prediction only]; Region: COG1123 481805000734 Walker A/P-loop; other site 481805000735 ATP binding site [chemical binding]; other site 481805000736 Q-loop/lid; other site 481805000737 ABC transporter signature motif; other site 481805000738 Walker B; other site 481805000739 D-loop; other site 481805000740 H-loop/switch region; other site 481805000741 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481805000742 Walker A/P-loop; other site 481805000743 ATP binding site [chemical binding]; other site 481805000744 Q-loop/lid; other site 481805000745 ABC transporter signature motif; other site 481805000746 Walker B; other site 481805000747 D-loop; other site 481805000748 H-loop/switch region; other site 481805000749 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 481805000750 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 481805000751 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 481805000752 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 481805000753 PAAR motif; Region: PAAR_motif; cl15808 481805000754 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805000755 RHS Repeat; Region: RHS_repeat; pfam05593 481805000756 RHS Repeat; Region: RHS_repeat; pfam05593 481805000757 RHS Repeat; Region: RHS_repeat; pfam05593 481805000758 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805000759 RHS Repeat; Region: RHS_repeat; pfam05593 481805000760 RHS Repeat; Region: RHS_repeat; pfam05593 481805000761 RHS protein; Region: RHS; pfam03527 481805000762 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 481805000763 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 481805000764 nickel responsive regulator; Provisional; Region: PRK02967 481805000765 NikR C terminal nickel binding domain; Region: NikR_C; pfam08753 481805000766 nickel transporter ATP-binding protein NikE; Provisional; Region: nikE; PRK10419 481805000767 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805000768 Walker A/P-loop; other site 481805000769 ATP binding site [chemical binding]; other site 481805000770 Q-loop/lid; other site 481805000771 ABC transporter signature motif; other site 481805000772 Walker B; other site 481805000773 D-loop; other site 481805000774 H-loop/switch region; other site 481805000775 nickel transporter ATP-binding protein NikD; Provisional; Region: nikD; PRK10418 481805000776 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805000777 Walker A/P-loop; other site 481805000778 ATP binding site [chemical binding]; other site 481805000779 Q-loop/lid; other site 481805000780 ABC transporter signature motif; other site 481805000781 Walker B; other site 481805000782 D-loop; other site 481805000783 H-loop/switch region; other site 481805000784 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 481805000785 nickel transporter permease NikC; Provisional; Region: nikC; PRK10417 481805000786 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805000787 dimer interface [polypeptide binding]; other site 481805000788 conserved gate region; other site 481805000789 putative PBP binding loops; other site 481805000790 ABC-ATPase subunit interface; other site 481805000791 nickel transporter permease NikB; Provisional; Region: PRK10352 481805000792 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805000793 dimer interface [polypeptide binding]; other site 481805000794 conserved gate region; other site 481805000795 putative PBP binding loops; other site 481805000796 ABC-ATPase subunit interface; other site 481805000797 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 481805000798 The substrate-binding component of an ABC-type nickel import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA; cd08489 481805000799 substrate binding site [chemical binding]; other site 481805000800 holo-(acyl carrier protein) synthase 2; Provisional; Region: PRK10351 481805000801 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 481805000802 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; cl00465 481805000803 Domain of unknown function DUF20; Region: UPF0118; pfam01594 481805000804 major facilitator superfamily transporter; Provisional; Region: PRK05122 481805000805 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805000806 putative substrate translocation pore; other site 481805000807 hypothetical protein; Provisional; Region: PRK11615 481805000808 hypothetical protein; Provisional; Region: PRK11212 481805000809 SirA (also known as UvrY, and YhhP) belongs to a family of two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system is a sensor kinase called BarA which phosphorylates SirA. A...; Region: SirA; cd03423 481805000810 CPxP motif; other site 481805000811 zinc/cadmium/mercury/lead-transporting ATPase; Provisional; Region: zntA; PRK11033 481805000812 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 481805000813 metal-binding site [ion binding] 481805000814 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 481805000815 Predicted membrane protein [Function unknown]; Region: COG3714 481805000816 Protein of unknown function (DUF2500); Region: DUF2500; pfam10694 481805000817 hypothetical protein; Provisional; Region: PRK10910 481805000818 N6-adenine-specific methylase [DNA replication, recombination, and repair]; Region: COG0742 481805000819 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805000820 S-adenosylmethionine binding site [chemical binding]; other site 481805000821 signal recognition particle-docking protein FtsY; Provisional; Region: PRK10416 481805000822 SRP54-type protein, helical bundle domain; Region: SRP54_N; pfam02881 481805000823 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 481805000824 P loop; other site 481805000825 GTP binding site [chemical binding]; other site 481805000826 cell division protein FtsE; Provisional; Region: PRK10908 481805000827 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805000828 Walker A/P-loop; other site 481805000829 ATP binding site [chemical binding]; other site 481805000830 Q-loop/lid; other site 481805000831 ABC transporter signature motif; other site 481805000832 Walker B; other site 481805000833 D-loop; other site 481805000834 H-loop/switch region; other site 481805000835 cell division ABC transporter subunit FtsX; Provisional; Region: ftsX; PRK11026 481805000836 putative protein insertion permease FtsX; Region: ftsX; TIGR00439 481805000837 RNA polymerase factor sigma-32; Reviewed; Region: PRK06596 481805000838 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481805000839 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481805000840 DNA binding residues [nucleotide binding] 481805000841 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 481805000842 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 481805000843 dimerization interface [polypeptide binding]; other site 481805000844 ligand binding site [chemical binding]; other site 481805000845 Acetyltransferase (GNAT) domain; Region: DUF3749; pfam12568 481805000846 ABC-type branched-chain amino acid transport systems, periplasmic component [Amino acid transport and metabolism]; Region: LivK; COG0683 481805000847 Type I periplasmic ligand-binding domain of ABC (Atpase Binding Cassette)-type active transport systems that are involved in the transport of all three branched chain aliphatic amino acids (leucine, isoleucine and valine); Region: PBP1_ABC_LIVBP_like; cd06342 481805000848 dimerization interface [polypeptide binding]; other site 481805000849 ligand binding site [chemical binding]; other site 481805000850 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481805000851 Transmembrane subunit (TM) of Escherichia coli LivH and related proteins. LivH is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivH_like; cd06582 481805000852 TM-ABC transporter signature motif; other site 481805000853 leucine/isoleucine/valine transporter permease subunit; Provisional; Region: livM; PRK11301 481805000854 Domain of unknown function (DUF3382); Region: DUF3382; pfam11862 481805000855 Transmembrane subunit (TM) of Escherichia coli LivM and related proteins. LivM is one of two TMs of the E. coli LIV-1/LS transporter, a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of...; Region: TM_PBP1_LivM_like; cd06581 481805000856 TM-ABC transporter signature motif; other site 481805000857 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livG; PRK11300 481805000858 ATP-binding cassette component of branched chain amino acids transport system; Region: ABC_Mj1267_LivG_branched; cd03219 481805000859 Walker A/P-loop; other site 481805000860 ATP binding site [chemical binding]; other site 481805000861 Q-loop/lid; other site 481805000862 ABC transporter signature motif; other site 481805000863 Walker B; other site 481805000864 D-loop; other site 481805000865 H-loop/switch region; other site 481805000866 leucine/isoleucine/valine transporter ATP-binding subunit; Provisional; Region: livF; PRK11614 481805000867 ATP-binding cassette domain of branched-chain amino acid transporter; Region: ABC_TM1139_LivF_branched; cd03224 481805000868 Walker A/P-loop; other site 481805000869 ATP binding site [chemical binding]; other site 481805000870 Q-loop/lid; other site 481805000871 ABC transporter signature motif; other site 481805000872 Walker B; other site 481805000873 D-loop; other site 481805000874 H-loop/switch region; other site 481805000875 glycerol-3-phosphate transporter periplasmic binding protein; Provisional; Region: PRK10974 481805000876 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481805000877 ABC-type polysaccharide transport system, permease component [Carbohydrate transport and metabolism]; Region: LplB; COG4209 481805000878 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805000879 dimer interface [polypeptide binding]; other site 481805000880 conserved gate region; other site 481805000881 putative PBP binding loops; other site 481805000882 ABC-ATPase subunit interface; other site 481805000883 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481805000884 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805000885 dimer interface [polypeptide binding]; other site 481805000886 conserved gate region; other site 481805000887 putative PBP binding loops; other site 481805000888 ABC-ATPase subunit interface; other site 481805000889 glycerol-3-phosphate transporter ATP-binding subunit; Provisional; Region: ugpC; PRK11650 481805000890 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 481805000891 Walker A/P-loop; other site 481805000892 ATP binding site [chemical binding]; other site 481805000893 Q-loop/lid; other site 481805000894 ABC transporter signature motif; other site 481805000895 Walker B; other site 481805000896 D-loop; other site 481805000897 H-loop/switch region; other site 481805000898 TOBE domain; Region: TOBE_2; pfam08402 481805000899 cytoplasmic glycerophosphodiester phosphodiesterase; Provisional; Region: ugpQ; PRK09454 481805000900 Glycerophosphodiester phosphodiesterase domain in Escherichia coli cytosolic glycerophosphodiester phosphodiesterase UgpQ and similar proteins; Region: GDPD_EcUgpQ_like; cd08562 481805000901 putative active site [active] 481805000902 catalytic site [active] 481805000903 putative metal binding site [ion binding]; other site 481805000904 hypothetical protein; Provisional; Region: PRK10350 481805000905 gamma-glutamyltranspeptidase; Reviewed; Region: ggt; PRK09615 481805000906 gamma-glutamyltranspeptidase; Region: g_glut_trans; TIGR00066 481805000907 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805000908 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805000909 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805000910 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805000911 putative acetyltransferase YhhY; Provisional; Region: PRK10140 481805000912 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481805000913 Coenzyme A binding pocket [chemical binding]; other site 481805000914 putative oxidoreductase; Provisional; Region: PRK10206 481805000915 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481805000916 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481805000917 Pirin-related protein [General function prediction only]; Region: COG1741 481805000918 Pirin; Region: Pirin; pfam02678 481805000919 gluconate operon transcriptional regulator; Provisional; Region: PRK14987 481805000920 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481805000921 DNA binding site [nucleotide binding] 481805000922 domain linker motif; other site 481805000923 Ligand-binding domain of DNA transcription repressor GntR specific for gluconate, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_GntR; cd01575 481805000924 putative ligand binding site [chemical binding]; other site 481805000925 putative dimerization interface [polypeptide binding]; other site 481805000926 Gluconate kinase (GntK) catalyzes the phosphoryl transfer from ATP to gluconate. The resulting product gluconate-6-phoshate is an important precursor of gluconate metabolism. GntK acts as a dimmer composed of two identical subunits; Region: GntK; cd02021 481805000927 Shikimate kinase; Region: SKI; pfam01202 481805000928 low affinity gluconate transporter; Provisional; Region: PRK10472 481805000929 gluconate transporter; Region: gntP; TIGR00791 481805000930 putative antibiotic transporter; Provisional; Region: PRK10739 481805000931 aspartate-semialdehyde dehydrogenase; Reviewed; Region: PRK06598 481805000932 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 481805000933 glycogen branching enzyme; Provisional; Region: PRK05402 481805000934 N-terminal Early set domain associated with the catalytic domain of prokaryotic glycogen branching enzyme; Region: E_set_GBE_prok_N; cd02855 481805000935 Alpha amylase catalytic domain found in the Glycogen branching enzyme (also called 1,4-alpha-glucan branching enzyme); Region: AmyAc_Glg_BE; cd11322 481805000936 active site 481805000937 catalytic site [active] 481805000938 Alpha amylase, C-terminal all-beta domain; Region: Alpha-amylase_C; pfam02806 481805000939 glycogen debranching enzyme; Provisional; Region: PRK03705 481805000940 N-terminal Early set domain associated with the catalytic domain of Glycogen debranching enzyme and bacterial isoamylase (also called glycogen 6-glucanohydrolase); Region: E_set_GDE_Isoamylase_N; cd02856 481805000941 Alpha amylase catalytic domain found in glycogen debranching enzymes; Region: AmyAc_Glg_debranch; cd11326 481805000942 active site 481805000943 catalytic site [active] 481805000944 glucose-1-phosphate adenylyltransferase; Provisional; Region: glgC; PRK00725 481805000945 ADP-glucose pyrophosphorylase is involved in the biosynthesis of glycogen or starch; Region: ADP_Glucose_PP; cd02508 481805000946 ligand binding site; other site 481805000947 oligomer interface; other site 481805000948 Glucose-1-phosphate adenylyltransferase, C-terminal Left-handed parallel beta helix (LbH) domain: Glucose-1-phosphate adenylyltransferase is also known as ADP-glucose synthase or ADP-glucose pyrophosphorylase. It catalyzes the first committed and...; Region: LbH_G1P_AT_C; cd04651 481805000949 sulfate 1 binding site; other site 481805000950 glycogen synthase; Provisional; Region: glgA; PRK00654 481805000951 This family is most closely related to the GT1 family of glycosyltransferases. Glycogen synthase catalyzes the formation and elongation of the alpha-1,4-glucose backbone using ADP-glucose, the second and key step of glycogen biosynthesis. This family...; Region: GT1_Glycogen_synthase_DULL1_like; cd03791 481805000952 ADP-binding pocket [chemical binding]; other site 481805000953 homodimer interface [polypeptide binding]; other site 481805000954 glycogen phosphorylase; Provisional; Region: PRK14986 481805000955 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 481805000956 homodimer interface [polypeptide binding]; other site 481805000957 active site pocket [active] 481805000958 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 481805000959 ABC-type phosphate transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: PstS; COG0226 481805000960 glycerol-3-phosphate dehydrogenase; Reviewed; Region: glpD; PRK12266 481805000961 GlpE sulfurtransferase (ST) and homologs are members of the Rhodanese Homology Domain superfamily. Unlike other rhodanese sulfurtransferases, GlpE is a single domain protein but indications are that it functions as a dimer. The active site contains a...; Region: GlpE_ST; cd01444 481805000962 active site residue [active] 481805000963 intramembrane serine protease GlpG; Provisional; Region: PRK10907 481805000964 Protein of unknown function (DUF3582); Region: DUF3582; pfam12122 481805000965 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 481805000966 DNA-binding transcriptional repressor GlpR; Provisional; Region: PRK10906 481805000967 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 481805000968 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481805000969 Sigma54-dependent transcription regulator containing an AAA-type ATPase domain and a DNA-binding domain [Transcription / Signal transduction mechanisms]; Region: RtcR; COG4650 481805000970 Regulator of RNA terminal phosphate cyclase; Region: RtcR; pfam06956 481805000971 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805000972 Walker A motif; other site 481805000973 ATP binding site [chemical binding]; other site 481805000974 Walker B motif; other site 481805000975 arginine finger; other site 481805000976 Uncharacterized protein family UPF0027; Region: UPF0027; pfam01139 481805000977 hypothetical protein; Reviewed; Region: PRK09588 481805000978 RNA 3'-terminal-phosphate cyclase; Provisional; Region: PRK04204 481805000979 This domain family includes the Enolpyruvate transferase (EPT) family and the RNA 3' phosphate cyclase family (RTPC). These 2 families differ in that EPT is formed by 3 repeats of an alpha-beta structural domain while RTPC has 3 similar repeats...; Region: EPT_RTPC-like; cl00288 481805000980 putative active site [active] 481805000981 transcriptional regulator MalT; Provisional; Region: PRK04841 481805000982 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805000983 DNA binding residues [nucleotide binding] 481805000984 dimerization interface [polypeptide binding]; other site 481805000985 maltodextrin phosphorylase; Provisional; Region: PRK14985 481805000986 This is a family of oligosaccharide phosphorylases. It includes yeast and mammalian glycogen phosphorylases, plant starch/glucan phosphorylase, as well as the maltodextrin phosphorylases of bacteria. The members of this family catalyze the breakdown of...; Region: GT1_Glycogen_Phosphorylase; cd04300 481805000987 homodimer interface [polypeptide binding]; other site 481805000988 active site pocket [active] 481805000989 4-alpha-glucanotransferase; Provisional; Region: malQ; PRK11052 481805000990 4-alpha-glucanotransferase; Region: malQ; TIGR00217 481805000991 high-affinity gluconate transporter; Provisional; Region: PRK14984 481805000992 gluconate transporter; Region: gntP; TIGR00791 481805000993 Fe/S biogenesis protein NfuA; Provisional; Region: PRK11190 481805000994 Fe-S cluster assembly scaffold protein [Posttranslational modification, protein turnover, chaperones]; Region: sufA; COG0316 481805000995 Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]; Region: COG0694 481805000996 DNA utilization protein GntX; Provisional; Region: PRK11595 481805000997 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481805000998 active site 481805000999 carboxylesterase BioH; Provisional; Region: PRK10349 481805001000 homoserine O-acetyltransferase; Provisional; Region: metX; cl17114 481805001001 putative transposase; Provisional; Region: PRK09857 481805001002 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 481805001003 ferrous iron transport protein FeoC; Provisional; Region: PRK15431 481805001004 ferrous iron transport protein B; Reviewed; Region: feoB; PRK09554 481805001005 Ferrous iron transport protein B (FeoB) family; Region: FeoB; cd01879 481805001006 G1 box; other site 481805001007 GTP/Mg2+ binding site [chemical binding]; other site 481805001008 Switch I region; other site 481805001009 G2 box; other site 481805001010 G3 box; other site 481805001011 Switch II region; other site 481805001012 G4 box; other site 481805001013 G5 box; other site 481805001014 Nucleoside recognition; Region: Gate; pfam07670 481805001015 Ferrous iron transport protein B C terminus; Region: FeoB_C; pfam07664 481805001016 Nucleoside recognition; Region: Gate; pfam07670 481805001017 ferrous iron transport protein A; Reviewed; Region: feoA; PRK09555 481805001018 Transcriptional accessory protein [Transcription]; Region: Tex; COG2183 481805001019 Tex-like protein N-terminal domain; Region: Tex_N; pfam09371 481805001020 Likely ribonuclease with RNase H fold; Region: YqgFc; smart00732 481805001021 S1_Tex: The C-terminal S1 domain of a transcription accessory factor called Tex, which has been characterized in Bordetella pertussis and Pseudomonas aeruginosa. The tex gene is essential in Bortella pertusis and is named for its role in toxin expression; Region: S1_Tex; cd05685 481805001022 RNA binding site [nucleotide binding]; other site 481805001023 transcription elongation factor GreB; Reviewed; Region: greB; PRK01885 481805001024 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 481805001025 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 481805001026 osmolarity response regulator; Provisional; Region: ompR; PRK09468 481805001027 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805001028 active site 481805001029 phosphorylation site [posttranslational modification] 481805001030 intermolecular recognition site; other site 481805001031 dimerization interface [polypeptide binding]; other site 481805001032 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805001033 DNA binding site [nucleotide binding] 481805001034 osmolarity sensor protein; Provisional; Region: envZ; PRK09467 481805001035 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805001036 dimerization interface [polypeptide binding]; other site 481805001037 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805001038 dimer interface [polypeptide binding]; other site 481805001039 phosphorylation site [posttranslational modification] 481805001040 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805001041 ATP binding site [chemical binding]; other site 481805001042 G-X-G motif; other site 481805001043 Phosphoenolpyruvate carboxykinase (PEPCK), a critical gluconeogenic enzyme, catalyzes the first committed step in the diversion of tricarboxylic acid cycle intermediates toward gluconeogenesis. It catalyzes the reversible decarboxylation and...; Region: PEPCK_ATP; cd00484 481805001044 Phosphoenolpyruvate carboxykinase; Region: PEPCK_ATP; pfam01293 481805001045 active site 481805001046 substrate-binding site [chemical binding]; other site 481805001047 metal-binding site [ion binding] 481805001048 ATP binding site [chemical binding]; other site 481805001049 Domain of unknown function (DUF4153); Region: DUF4153; pfam13687 481805001050 Hsp33-like chaperonin; Reviewed; Region: hslO; PRK00114 481805001051 Heat shock protein 33 (Hsp33): Cytosolic protein that acts as a molecular chaperone under oxidative conditions. In normal (reducing) cytosolic conditions, four conserved Cys residues are coordinated by a Zn ion. Under oxidative stress (such as heat...; Region: Hsp33; cd00498 481805001052 dimerization interface [polypeptide binding]; other site 481805001053 domain crossover interface; other site 481805001054 redox-dependent activation switch; other site 481805001055 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481805001056 RNA binding surface [nucleotide binding]; other site 481805001057 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 481805001058 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805001059 motif II; other site 481805001060 Intracellular growth attenuator protein IgaA; Region: IgaA; pfam07095 481805001061 adenosine nucleotide hydrolase NudE; Provisional; Region: nudE; PRK11762 481805001062 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 481805001063 ADP-ribose binding site [chemical binding]; other site 481805001064 dimer interface [polypeptide binding]; other site 481805001065 active site 481805001066 nudix motif; other site 481805001067 metal binding site [ion binding]; metal-binding site 481805001068 penicillin-binding protein 1a; Provisional; Region: mrcA; PRK11636 481805001069 Transglycosylase; Region: Transgly; pfam00912 481805001070 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 481805001071 Tfp pilus assembly protein PilN [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilN; COG3166 481805001072 Fimbrial assembly protein (PilN); Region: PilN; pfam05137 481805001073 Protein of unknown function (DUF2531); Region: DUF2531; pfam10748 481805001074 outer membrane porin HofQ; Provisional; Region: hofQ; PRK10560 481805001075 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 481805001076 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 481805001077 shikimate kinase; Reviewed; Region: aroK; PRK00131 481805001078 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 481805001079 ADP binding site [chemical binding]; other site 481805001080 magnesium binding site [ion binding]; other site 481805001081 putative shikimate binding site; other site 481805001082 Dehydroquinate synthase (DHQS) catalyzes the conversion of DAHP to DHQ in shikimate pathway for aromatic compounds synthesis; Region: DHQS; cd08195 481805001083 active site 481805001084 dimer interface [polypeptide binding]; other site 481805001085 metal binding site [ion binding]; metal-binding site 481805001086 Uncharacterized protein conserved in bacteria [Function unknown]; Region: DamX; COG3266 481805001087 cell division protein DamX; Validated; Region: PRK10905 481805001088 DNA adenine methylase; Provisional; Region: PRK10904 481805001089 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 481805001090 ribulose-phosphate 3-epimerase; Region: rpe; TIGR01163 481805001091 substrate binding site [chemical binding]; other site 481805001092 hexamer interface [polypeptide binding]; other site 481805001093 metal binding site [ion binding]; metal-binding site 481805001094 phosphoglycolate phosphatase; Provisional; Region: PRK13222 481805001095 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805001096 motif II; other site 481805001097 tryptophanyl-tRNA synthetase II; Reviewed; Region: PRK12282 481805001098 catalytic core domain of tryptophanyl-tRNA synthetase; Region: TrpRS_core; cd00806 481805001099 active site 481805001100 HIGH motif; other site 481805001101 dimer interface [polypeptide binding]; other site 481805001102 KMSKS motif; other site 481805001103 PRD domain protein EF_0829/AHA_3910; Region: EF_0829; TIGR03582 481805001104 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme yhfX; Region: PLPDE_III_yhfX_like; cd06811 481805001105 dimer interface [polypeptide binding]; other site 481805001106 Predicted amino acid racemase [Amino acid transport and metabolism]; Region: COG3457 481805001107 active site 481805001108 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 481805001109 substrate binding site [chemical binding]; other site 481805001110 catalytic residue [active] 481805001111 putative mutase; Provisional; Region: PRK12383 481805001112 Phosphopentomutase [Carbohydrate transport and metabolism]; Region: DeoB; COG1015 481805001113 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 481805001114 Phosphotriesterase (PTE) catalyzes the hydrolysis of organophosphate nerve agents, including the chemical warfare agents VX, soman, and sarin as well as the insecticide paraoxon. PTE exists as a homodimer with one active site per monomer. The active site...; Region: PTE; cd00530 481805001115 active site 481805001116 substrate binding pocket [chemical binding]; other site 481805001117 homodimer interaction site [polypeptide binding]; other site 481805001118 Protein of unknown function DUF2620; Region: DUF2620; pfam10941 481805001119 Protein of unknown function; Region: YhfT; pfam10797 481805001120 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 481805001121 DNA-binding transcriptional regulator FrlR; Provisional; Region: PRK11402 481805001122 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805001123 DNA-binding site [nucleotide binding]; DNA binding site 481805001124 UTRA domain; Region: UTRA; pfam07702 481805001125 Fructoselysine kinase-like. Fructoselysine is a fructoseamine formed by glycation, a non-enzymatic reaction of glucose with a primary amine followed by an Amadori rearrangement, resulting in a protein that is modified at the amino terminus and at the...; Region: Fructoselysine_kinase_like; cd01940 481805001126 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 481805001127 substrate binding site [chemical binding]; other site 481805001128 ATP binding site [chemical binding]; other site 481805001129 fructoselysine 3-epimerase; Provisional; Region: PRK09856 481805001130 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cl12060 481805001131 AP (apurinic/apyrimidinic) site pocket; other site 481805001132 DNA interaction; other site 481805001133 Metal-binding active site; metal-binding site 481805001134 fructoselysine-6-P-deglycase; Provisional; Region: frlB; PRK11382 481805001135 SIS domain. SIS (Sugar ISomerase) domains are found in many phosphosugar isomerases and phosphosugar binding proteins. SIS domains are also found in proteins that regulate the expression of genes involved in synthesis of phosphosugars; Region: SIS; cl00389 481805001136 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 481805001137 dimer interface [polypeptide binding]; other site 481805001138 active site 481805001139 putative fructoselysine transporter; Provisional; Region: frlA; PRK11357 481805001140 hypothetical protein; Provisional; Region: PHA02764 481805001141 Protein of unknown function (DUF4223); Region: DUF4223; pfam13978 481805001142 siroheme synthase; Provisional; Region: cysG; PRK10637 481805001143 Putative NAD(P)-binding; Region: NAD_binding_7; pfam13241 481805001144 Sirohaem synthase dimerisation region; Region: CysG_dimeriser; pfam10414 481805001145 Uroporphyrin-III C-methyltransferase (S-Adenosyl-L-methionine:uroporphyrinogen III methyltransferase, SUMT); Region: SUMT; cd11642 481805001146 active site 481805001147 SAM binding site [chemical binding]; other site 481805001148 homodimer interface [polypeptide binding]; other site 481805001149 nitrite transporter NirC; Provisional; Region: PRK11562 481805001150 Assimilatory nitrite reductase (NirD) family, Rieske domain; Assimilatory nitrate and nitrite reductases convert nitrate through nitrite to ammonium. Members include bacterial and fungal proteins. The bacterial NirD contains a single Rieske domain while...; Region: Rieske_NirD; cd03529 481805001151 nitrite reductase subunit NirD; Provisional; Region: PRK14989 481805001152 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805001153 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 481805001154 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 481805001155 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 481805001156 putative transporter; Provisional; Region: PRK03699 481805001157 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805001158 putative substrate translocation pore; other site 481805001159 peptidyl-prolyl cis-trans isomerase A (rotamase A); Provisional; Region: PRK10903 481805001160 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 481805001161 substrate binding site [chemical binding]; other site 481805001162 hypothetical protein; Provisional; Region: PRK10204 481805001163 Protein involved in cell division [Cell division and chromosome partitioning]; Region: Fic; COG2184 481805001164 cell filamentation protein Fic; Provisional; Region: PRK10347 481805001165 para-aminobenzoate synthase component II; Provisional; Region: PRK08857 481805001166 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 481805001167 glutamine binding [chemical binding]; other site 481805001168 catalytic triad [active] 481805001169 bifunctional N-succinyldiaminopimelate-aminotransferase/acetylornithine transaminase protein; Reviewed; Region: argD; PRK05093 481805001170 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 481805001171 inhibitor-cofactor binding pocket; inhibition site 481805001172 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805001173 catalytic residue [active] 481805001174 integral membrane protein, YccS/YhfK family; Region: YCCS_YHJK; TIGR01667 481805001175 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 481805001176 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 481805001177 DNA-binding transcriptional dual regulator Crp; Provisional; Region: PRK11753 481805001178 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 481805001179 ligand binding site [chemical binding]; other site 481805001180 flexible hinge region; other site 481805001181 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 481805001182 putative switch regulator; other site 481805001183 non-specific DNA interactions [nucleotide binding]; other site 481805001184 DNA binding site [nucleotide binding] 481805001185 sequence specific DNA binding site [nucleotide binding]; other site 481805001186 putative cAMP binding site [chemical binding]; other site 481805001187 hypothetical protein; Provisional; Region: PRK10738 481805001188 Phosphoribulokinase-like (PRK-like) is a family of proteins similar to phosphoribulokinase (PRK), the enzyme involved in the Benson-Calvin cycle in chloroplasts or photosynthetic prokaryotes. PRK catalyzes the phosphorylation of D-ribulose 5-phosphate to...; Region: PRK_like; cd02029 481805001189 active site 481805001190 hypothetical protein; Provisional; Region: PRK04966 481805001191 putative hydrolase; Provisional; Region: PRK10985 481805001192 putative ABC transporter ATP-binding protein; Provisional; Region: PRK10636 481805001193 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805001194 Walker A/P-loop; other site 481805001195 ATP binding site [chemical binding]; other site 481805001196 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481805001197 ABC transporter signature motif; other site 481805001198 Walker B; other site 481805001199 D-loop; other site 481805001200 ABC transporter; Region: ABC_tran_2; pfam12848 481805001201 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481805001202 glutathione-regulated potassium-efflux system ancillary protein KefG; Provisional; Region: PRK04930 481805001203 glutathione-regulated potassium-efflux system protein KefB; Provisional; Region: PRK03659 481805001204 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 481805001205 TrkA-N domain; Region: TrkA_N; pfam02254 481805001206 Predicted nucleic-acid-binding protein containing a Zn-ribbon domain [General function prediction only]; Region: COG3529 481805001207 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 481805001208 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 481805001209 phi X174 lysis protein; Provisional; Region: PRK02793 481805001210 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK10902 481805001211 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 481805001212 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 481805001213 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2964 481805001214 YheO-like PAS domain; Region: PAS_6; pfam08348 481805001215 HTH domain; Region: HTH_22; pfam13309 481805001216 sulfur transfer complex subunit TusD; Validated; Region: PRK00207 481805001217 sulfur relay protein TusC; Validated; Region: PRK00211 481805001218 sulfur transfer complex subunit TusB; Provisional; Region: PRK13510 481805001219 S12-like family, 30S ribosomal protein S12 subfamily; S12 is located at the interface of the large and small ribosomal subunits of prokaryotes, chloroplasts and mitochondria, where it plays an important role in both tRNA and ribosomal subunit...; Region: Ribosomal_S12; cd03368 481805001220 S17 interaction site [polypeptide binding]; other site 481805001221 S8 interaction site; other site 481805001222 16S rRNA interaction site [nucleotide binding]; other site 481805001223 streptomycin interaction site [chemical binding]; other site 481805001224 23S rRNA interaction site [nucleotide binding]; other site 481805001225 aminoacyl-tRNA interaction site (A-site) [nucleotide binding]; other site 481805001226 30S ribosomal protein S7; Validated; Region: PRK05302 481805001227 elongation factor G; Reviewed; Region: PRK00007 481805001228 Elongation factor G (EF-G) family involved in both the elongation and ribosome recycling phases of protein synthesis; Region: EF-G; cd01886 481805001229 G1 box; other site 481805001230 putative GEF interaction site [polypeptide binding]; other site 481805001231 GTP/Mg2+ binding site [chemical binding]; other site 481805001232 Switch I region; other site 481805001233 G2 box; other site 481805001234 G3 box; other site 481805001235 Switch II region; other site 481805001236 G4 box; other site 481805001237 G5 box; other site 481805001238 EFG_mtEFG_II: this subfamily represents the domain II of elongation factor G (EF-G) in bacteria and, the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2)_like proteins found in eukaryotes. During the process of peptide synthesis...; Region: EFG_mtEFG_II; cd04088 481805001239 EFG_mtEFG1_IV: domains similar to domain IV of the bacterial translational elongation factor (EF) EF-G. Included in this group is a domain of mitochondrial Elongation factor G1 (mtEFG1) proteins homologous to domain IV of EF-G. Eukaryotic cells harbor 2...; Region: EFG_mtEFG1_IV; cd01434 481805001240 EFG_mtEFG_C: domains similar to the C-terminal domain of the bacterial translational elongation factor (EF) EF-G. Included in this group is the C-terminus of mitochondrial Elongation factor G1 (mtEFG1) and G2 (mtEFG2) proteins. Eukaryotic cells harbor 2...; Region: EFG_mtEFG_C; cd03713 481805001241 elongation factor Tu; Reviewed; Region: PRK00049 481805001242 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 481805001243 G1 box; other site 481805001244 GEF interaction site [polypeptide binding]; other site 481805001245 GTP/Mg2+ binding site [chemical binding]; other site 481805001246 Switch I region; other site 481805001247 G2 box; other site 481805001248 G3 box; other site 481805001249 Switch II region; other site 481805001250 G4 box; other site 481805001251 G5 box; other site 481805001252 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 481805001253 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 481805001254 Antibiotic Binding Site [chemical binding]; other site 481805001255 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 481805001256 Chitin/cellulose binding domains of chitinase and related enzymes; Region: ChtBD3; cl00046 481805001257 Chitin-binding domain of chitinase C; Region: ChiC_BD; cd12215 481805001258 aromatic chitin/cellulose binding site residues [chemical binding]; other site 481805001259 PF-ChiA is an uncharacterized chitinase found in the hyperthermophilic archaeon Pyrococcus furiosus with a glycosyl hydrolase family 18 (GH18) catalytic domain as well as a cellulose-binding domain. Members of this domain family are found not only in...; Region: GH18_PF-ChiA-like; cd06543 481805001260 active site 481805001261 bacterioferritin-associated ferredoxin; Provisional; Region: PRK10509 481805001262 Bacterioferritin (cytochrome b1) [Inorganic ion transport and metabolism]; Region: Bfr; COG2193 481805001263 Bacterioferritin, ferritin-like diiron-binding domain; Region: Bacterioferritin; cd00907 481805001264 heme binding site [chemical binding]; other site 481805001265 ferroxidase pore; other site 481805001266 ferroxidase diiron center [ion binding]; other site 481805001267 Type II secretory pathway, prepilin signal peptidase PulO and related peptidases [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: PulO; COG1989 481805001268 Type IV leader peptidase family; Region: Peptidase_A24; pfam01478 481805001269 Type II secretion system (T2SS), protein M; Region: T2SM; pfam04612 481805001270 Type II secretory pathway, component PulL [Intracellular trafficking and secretion]; Region: PulL; COG3297 481805001271 Type II secretion system (T2SS), protein L; Region: T2SL; pfam05134 481805001272 GspL periplasmic domain; Region: GspL_C; pfam12693 481805001273 Type II secretory pathway, component PulK [Intracellular trafficking and secretion]; Region: PulK; COG3156 481805001274 Type II secretory pathway, component PulJ [Intracellular trafficking and secretion]; Region: PulJ; COG4795 481805001275 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 481805001276 Type II secretion system (T2SS), protein J; Region: T2SJ; pfam11612 481805001277 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; cl06830 481805001278 type II secretion system protein I; Region: gspI; TIGR01707 481805001279 Type II secretion system (T2SS), protein I; Region: T2SI; pfam02501 481805001280 prepilin-type N-terminal cleavage/methylation domain; Region: IV_pilin_GFxxxE; TIGR02532 481805001281 type II secretion system protein G; Region: typeII_sec_gspG; TIGR01710 481805001282 Type II secretion system (T2SS), protein G; Region: T2SG; pfam08334 481805001283 type II secretion system protein F; Region: GspF; TIGR02120 481805001284 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 481805001285 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 481805001286 Type II secretory pathway, ATPase PulE/Tfp pilus assembly pathway, ATPase PilB [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PulE; COG2804 481805001287 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 481805001288 Walker A motif; other site 481805001289 ATP binding site [chemical binding]; other site 481805001290 Walker B motif; other site 481805001291 type II secretion system protein D; Region: type_II_gspD; TIGR02517 481805001292 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 481805001293 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 481805001294 Bacterial type II/III secretion system short domain; Region: Secretin_N; pfam03958 481805001295 Bacterial type II and III secretion system protein; Region: Secretin; pfam00263 481805001296 Type II secretory pathway, component PulC [Intracellular trafficking and secretion]; Region: PulC; COG3031 481805001297 Type IV pilus biogenesis; Region: Pilus_PilP; pfam11356 481805001298 AAA domain; Region: AAA_22; pfam13401 481805001299 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 481805001300 protein secretion protein GspB; Provisional; Region: PRK09697 481805001301 30S ribosomal protein S10; Reviewed; Region: rpsJ; PRK00596 481805001302 50S ribosomal protein L3, bacterial; Region: L3_bact; TIGR03625 481805001303 50S ribosomal protein L4; Provisional; Region: rplD; PRK05319 481805001304 50S ribosomal protein L23; Reviewed; Region: rplW; PRK05738 481805001305 50S ribosomal protein L2; Validated; Region: rplB; PRK09374 481805001306 Ribosomal Proteins L2, RNA binding domain; Region: Ribosomal_L2; pfam00181 481805001307 Ribosomal Proteins L2, C-terminal domain; Region: Ribosomal_L2_C; pfam03947 481805001308 30S ribosomal protein S19; Reviewed; Region: rpsS; PRK00357 481805001309 Ribosomal protein L22/L17e. L22 (L17 in eukaryotes) is a core protein of the large ribosomal subunit. It is the only ribosomal protein that interacts with all six domains of 23S rRNA, and is one of the proteins important for directing the proper...; Region: Ribosomal_L22; cd00336 481805001310 protein-rRNA interface [nucleotide binding]; other site 481805001311 putative translocon binding site; other site 481805001312 30S ribosomal protein S3; Reviewed; Region: rpsC; PRK00310 481805001313 K homology RNA-binding (KH) domain of the prokaryotic 30S small ribosomal subunit protein S3. S3 is part of the head region of the 30S ribosomal subunit and is believed to interact with mRNA as it threads its way from the latch into the channel. The KH...; Region: 30S_S3_KH; cd02412 481805001314 G-X-X-G motif; other site 481805001315 Ribosomal protein S3, C-terminal domain; Region: Ribosomal_S3_C; pfam00189 481805001316 Ribosomal_L16_L10e: L16 is an essential protein in the large ribosomal subunit of bacteria, mitochondria, and chloroplasts. Large subunits that lack L16 are defective in peptidyl transferase activity, peptidyl-tRNA hydrolysis activity, association with...; Region: Ribosomal_L16_L10e; cd01433 481805001317 23S rRNA interface [nucleotide binding]; other site 481805001318 5S rRNA interface [nucleotide binding]; other site 481805001319 putative antibiotic binding site [chemical binding]; other site 481805001320 L25 interface [polypeptide binding]; other site 481805001321 L27 interface [polypeptide binding]; other site 481805001322 Ribosomal L29 protein/HIP. L29 is a protein of the large ribosomal Subunit. A homolog, called heparin/heparan sulfate interacting protein (HIP), has also been identified in mammals. L29 is located on the surface of the large ribosomal subunit, where it...; Region: Ribosomal_L29_HIP; cd00427 481805001323 23S rRNA interface [nucleotide binding]; other site 481805001324 putative translocon interaction site; other site 481805001325 signal recognition particle (SRP54) interaction site; other site 481805001326 L23 interface [polypeptide binding]; other site 481805001327 trigger factor interaction site; other site 481805001328 30S ribosomal protein S17; Reviewed; Region: rpsQ; PRK05610 481805001329 50S ribosomal protein L14; Validated; Region: rplN; PRK05483 481805001330 50S ribosomal protein L24; Reviewed; Region: rplX; PRK00004 481805001331 KOW motif of Ribosomal Protein L26; Region: KOW_RPL26; cd06089 481805001332 RNA binding site [nucleotide binding]; other site 481805001333 50S ribosomal protein L5; Validated; Region: rplE; PRK00010 481805001334 Ribosomal protein L5; Region: Ribosomal_L5; pfam00281 481805001335 ribosomal L5P family C-terminus; Region: Ribosomal_L5_C; pfam00673 481805001336 30S ribosomal protein S14; Reviewed; Region: rpsN; PRK08881 481805001337 30S ribosomal protein S8; Validated; Region: rpsH; PRK00136 481805001338 50S ribosomal protein L6; Validated; Region: rplF; PRK05498 481805001339 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 481805001340 Ribosomal protein L6; Region: Ribosomal_L6; pfam00347 481805001341 Ribosomal L18/L5e: L18 (L5e) is a ribosomal protein found in the central protuberance (CP) of the large subunit. L18 binds 5S rRNA and induces a conformational change that stimulates the binding of L5 to 5S rRNA. Association of 5S rRNA with 23S rRNA...; Region: Ribosomal_L18_L5e; cd00432 481805001342 23S rRNA interface [nucleotide binding]; other site 481805001343 5S rRNA interface [nucleotide binding]; other site 481805001344 L27 interface [polypeptide binding]; other site 481805001345 L5 interface [polypeptide binding]; other site 481805001346 30S ribosomal protein S5; Validated; Region: rpsE; PRK00550 481805001347 Ribosomal protein S5, N-terminal domain; Region: Ribosomal_S5; pfam00333 481805001348 Ribosomal protein S5, C-terminal domain; Region: Ribosomal_S5_C; pfam03719 481805001349 Ribosomal protein L30, which is found in eukaryotes and prokaryotes but not in archaea, is one of the smallest ribosomal proteins with a molecular mass of about 7kDa. L30 binds the 23SrRNA as well as the 5S rRNA and is one of five ribosomal proteins that...; Region: Ribosomal_L30; cd01658 481805001350 23S rRNA binding site [nucleotide binding]; other site 481805001351 50S ribosomal protein L15; Reviewed; Region: rplO; PRK05592 481805001352 preprotein translocase subunit SecY; Reviewed; Region: secY; PRK09204 481805001353 SecY translocase; Region: SecY; pfam00344 481805001354 Ribosomal protein L36; Region: Ribosomal_L36; pfam00444 481805001355 30S ribosomal protein S13; Validated; Region: rpsM; PRK05179 481805001356 30S ribosomal protein S13; Region: bact_S13; TIGR03631 481805001357 30S ribosomal protein S11; Validated; Region: PRK05309 481805001358 30S ribosomal protein S4; Validated; Region: rpsD; PRK05327 481805001359 Ribosomal protein S4/S9 N-terminal domain; Region: Ribosomal_S4; pfam00163 481805001360 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481805001361 RNA binding surface [nucleotide binding]; other site 481805001362 DNA-directed RNA polymerase subunit alpha; Provisional; Region: PRK05182 481805001363 N-terminal domain of the Alpha subunit of Bacterial RNA polymerase; Region: RNAP_alpha_NTD; cd06928 481805001364 alphaNTD homodimer interface [polypeptide binding]; other site 481805001365 alphaNTD - beta interaction site [polypeptide binding]; other site 481805001366 alphaNTD - beta' interaction site [polypeptide binding]; other site 481805001367 Bacterial RNA polymerase, alpha chain C terminal domain; Region: RNA_pol_A_CTD; pfam03118 481805001368 50S ribosomal protein L17; Validated; Region: rplQ; PRK05591 481805001369 hypothetical protein; Provisional; Region: PRK10203 481805001370 zinc-responsive transcriptional regulator; Provisional; Region: zntR; PRK09514 481805001371 Helix-Turn-Helix DNA binding domain of Heavy Metal Resistance transcription regulators; Region: HTH_HMRTR; cd04770 481805001372 DNA binding residues [nucleotide binding] 481805001373 dimer interface [polypeptide binding]; other site 481805001374 metal binding site [ion binding]; metal-binding site 481805001375 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3036 481805001376 large-conductance mechanosensitive channel; Reviewed; Region: mscL; PRK00567 481805001377 Large-conductance mechanosensitive channel, MscL; Region: MscL; pfam01741 481805001378 potassium transporter peripheral membrane component; Reviewed; Region: trkA; PRK09496 481805001379 TrkA-N domain; Region: TrkA_N; pfam02254 481805001380 TrkA-C domain; Region: TrkA_C; pfam02080 481805001381 TrkA-N domain; Region: TrkA_N; pfam02254 481805001382 TrkA-C domain; Region: TrkA_C; pfam02080 481805001383 N-terminal RNA binding domain of the methyltransferase Sun. The rRNA-specific 5-methylcytidine transferase Sun, also known as RrmB or Fmu shares the RNA-binding non-catalytic domain with the transcription termination factor NusB. The precise biological...; Region: Methyltransferase_Sun; cd00620 481805001384 putative RNA binding site [nucleotide binding]; other site 481805001385 16S rRNA methyltransferase B; Provisional; Region: PRK10901 481805001386 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805001387 S-adenosylmethionine binding site [chemical binding]; other site 481805001388 methionyl-tRNA formyltransferase; Reviewed; Region: fmt; PRK00005 481805001389 Methionyl-tRNA formyltransferase, N-terminal hydrolase domain; Region: FMT_core_Met-tRNA-FMT_N; cd08646 481805001390 putative active site [active] 481805001391 substrate binding site [chemical binding]; other site 481805001392 putative cosubstrate binding site; other site 481805001393 catalytic site [active] 481805001394 C-terminal domain of Formyltransferase and other enzymes; Region: Met_tRNA_FMT_C; cd08704 481805001395 substrate binding site [chemical binding]; other site 481805001396 Polypeptide or peptide deformylase; a family of metalloenzymes that catalyzes the removal of the N-terminal formyl group in a growing polypeptide chain following translation initiation during protein synthesis in prokaryotes. These enzymes utilize Fe(II)...; Region: Pep_deformylase; cd00487 481805001397 active site 481805001398 catalytic residues [active] 481805001399 metal binding site [ion binding]; metal-binding site 481805001400 hypothetical protein; Provisional; Region: PRK10736 481805001401 DNA protecting protein DprA; Region: dprA; TIGR00732 481805001402 hypothetical protein; Validated; Region: PRK03430 481805001403 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 481805001404 Zn-finger domain associated with topoisomerase type I [DNA replication, recombination, and repair]; Region: TopA; COG0551 481805001405 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 481805001406 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 481805001407 tRNA(ANN) t(6)A37 threonylcarbamoyladenosine modification protein; Provisional; Region: PRK10634 481805001408 shikimate 5-dehydrogenase; Region: aroE; TIGR00507 481805001409 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 481805001410 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 481805001411 shikimate binding site; other site 481805001412 NAD(P) binding site [chemical binding]; other site 481805001413 Protein of unknown function (DUF1488); Region: DUF1488; pfam07369 481805001414 Carbonic anhydrases/acetyltransferases, isoleucine patch superfamily [General function prediction only]; Region: PaaY; COG0663 481805001415 Gamma carbonic anhydrase-like: This family is composed of gamma carbonic anhydrase (CA), Ferripyochelin Binding Protein (FBP), E. coli paaY protein, and similar proteins. CAs are zinc-containing enzymes that catalyze the reversible hydration of carbon...; Region: LbH_gamma_CA_like; cd04645 481805001416 trimer interface [polypeptide binding]; other site 481805001417 putative metal binding site [ion binding]; other site 481805001418 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 481805001419 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 481805001420 Walker A/P-loop; other site 481805001421 ATP binding site [chemical binding]; other site 481805001422 Q-loop/lid; other site 481805001423 ABC transporter signature motif; other site 481805001424 Walker B; other site 481805001425 D-loop; other site 481805001426 H-loop/switch region; other site 481805001427 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 481805001428 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805001429 dimer interface [polypeptide binding]; other site 481805001430 conserved gate region; other site 481805001431 putative PBP binding loops; other site 481805001432 ABC-ATPase subunit interface; other site 481805001433 ABC-type amino acid transport system, permease component [Amino acid transport and metabolism]; Region: BatB; COG4597 481805001434 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805001435 conserved gate region; other site 481805001436 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805001437 dimer interface [polypeptide binding]; other site 481805001438 conserved gate region; other site 481805001439 putative PBP binding loops; other site 481805001440 ABC-ATPase subunit interface; other site 481805001441 Bacterial periplasmic substrate-binding proteins; Region: PBPb; smart00062 481805001442 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805001443 substrate binding pocket [chemical binding]; other site 481805001444 membrane-bound complex binding site; other site 481805001445 hinge residues; other site 481805001446 Prokaryotic membrane lipoprotein lipid attachment site; Region: LPAM_1; pfam08139 481805001447 The (Largely Gram-negative Bacterial) Hydrophobe/Amphiphile Efflux-1 (HAE1) Family; Region: 2A0602; TIGR00915 481805001448 Protein export membrane protein; Region: SecD_SecF; cl14618 481805001449 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 481805001450 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481805001451 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805001452 DNA-binding transcriptional regulator EnvR; Provisional; Region: PRK09975 481805001453 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481805001454 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 481805001455 Protein of unknown function (DUF2556); Region: DUF2556; pfam10831 481805001456 DNA modification methylase [DNA replication, recombination, and repair]; Region: COG0863 481805001457 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805001458 DNA methylase; Region: N6_N4_Mtase; pfam01555 481805001459 Factor for inversion stimulation Fis, transcriptional activator [Transcription / DNA replication, recombination, and repair]; Region: Fis; COG2901 481805001460 global DNA-binding transcriptional dual regulator Fis; Provisional; Region: fis; PRK00430 481805001461 tRNA-dihydrouridine synthase B; Provisional; Region: PRK10415 481805001462 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 481805001463 FMN binding site [chemical binding]; other site 481805001464 active site 481805001465 catalytic residues [active] 481805001466 substrate binding site [chemical binding]; other site 481805001467 Ribosomal protein L11 methyltransferase (PrmA); Region: PrmA; pfam06325 481805001468 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 481805001469 Na(+)/pantothenate cotransporters: PanF of Escherichia coli and related proteins; solute binding domain; Region: SLC5sbd_PanF; cd10327 481805001470 Na binding site [ion binding]; other site 481805001471 hypothetical protein; Provisional; Region: PRK10633 481805001472 acetyl-CoA carboxylase biotin carboxylase subunit; Validated; Region: PRK08591 481805001473 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 481805001474 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 481805001475 Biotin carboxylase C-terminal domain; Region: Biotin_carb_C; smart00878 481805001476 acetyl-CoA carboxylase biotin carboxyl carrier protein subunit; Validated; Region: PRK06302 481805001477 The biotinyl-domain or biotin carboxyl carrier protein (BCCP) domain is present in all biotin-dependent enzymes, such as acetyl-CoA carboxylase, pyruvate carboxylase, propionyl-CoA carboxylase, methylcrotonyl-CoA carboxylase, geranyl-CoA carboxylase; Region: biotinyl_domain; cd06850 481805001478 carboxyltransferase (CT) interaction site; other site 481805001479 biotinylation site [posttranslational modification]; other site 481805001480 Protein of unknown function (DUF1444); Region: DUF1444; cl02011 481805001481 Yhdh putative quinone oxidoreductases; Region: MDR_yhdh; cd08288 481805001482 putative quinone oxidoreductase, YhdH/YhfP family; Region: oxido_YhdH; TIGR02823 481805001483 NADP binding site [chemical binding]; other site 481805001484 dimer interface [polypeptide binding]; other site 481805001485 regulatory protein CsrD; Provisional; Region: PRK11059 481805001486 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805001487 metal binding site [ion binding]; metal-binding site 481805001488 active site 481805001489 I-site; other site 481805001490 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805001491 rod shape-determining protein MreB; Provisional; Region: PRK13927 481805001492 MreB and similar proteins; Region: MreB_like; cd10225 481805001493 nucleotide binding site [chemical binding]; other site 481805001494 Mg binding site [ion binding]; other site 481805001495 putative protofilament interaction site [polypeptide binding]; other site 481805001496 RodZ interaction site [polypeptide binding]; other site 481805001497 rod shape-determining protein MreC; Region: mreC; TIGR00219 481805001498 rod shape-determining protein MreC; Region: MreC; pfam04085 481805001499 rod shape-determining protein MreD; Provisional; Region: PRK11060 481805001500 Maf-like protein; Region: Maf; pfam02545 481805001501 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 481805001502 active site 481805001503 dimer interface [polypeptide binding]; other site 481805001504 ribonuclease G; Provisional; Region: PRK11712 481805001505 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 481805001506 homodimer interface [polypeptide binding]; other site 481805001507 oligonucleotide binding site [chemical binding]; other site 481805001508 hypothetical protein; Provisional; Region: PRK10899 481805001509 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 481805001510 protease TldD; Provisional; Region: tldD; PRK10735 481805001511 transcriptional regulator; Provisional; Region: PRK10632 481805001512 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805001513 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA and its related homologs, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA_like; cd08422 481805001514 putative effector binding pocket; other site 481805001515 dimerization interface [polypeptide binding]; other site 481805001516 efflux system membrane protein; Provisional; Region: PRK11594 481805001517 p-hydroxybenzoic acid efflux subunit AaeA; Provisional; Region: PRK10559 481805001518 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481805001519 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805001520 p-hydroxybenzoic acid efflux subunit AaeB; Provisional; Region: PRK10631 481805001521 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 481805001522 Barstar is an intracellular inhibitor of barnase, an extracellular ribonuclease of Bacillus amyloliquefaciens. Barstar binds tightly to the barnase active site and sterically blocks it thus inhibiting its potentially lethal RNase activity inside the cell; Region: Barstar; cd05142 481805001523 RNAase interaction site [polypeptide binding]; other site 481805001524 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 481805001525 arginine repressor; Provisional; Region: PRK05066 481805001526 Arginine repressor, DNA binding domain; Region: Arg_repressor; pfam01316 481805001527 Arginine repressor, C-terminal domain; Region: Arg_repressor_C; pfam02863 481805001528 malate dehydrogenase; Provisional; Region: PRK05086 481805001529 Glyoxysomal and mitochondrial malate dehydrogenases; Region: MDH_glyoxysomal_mitochondrial; cd01337 481805001530 NAD binding site [chemical binding]; other site 481805001531 dimerization interface [polypeptide binding]; other site 481805001532 Substrate binding site [chemical binding]; other site 481805001533 serine endoprotease; Provisional; Region: PRK10898 481805001534 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 481805001535 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 481805001536 serine endoprotease; Provisional; Region: PRK10139 481805001537 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 481805001538 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 481805001539 protein binding site [polypeptide binding]; other site 481805001540 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 481805001541 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3105 481805001542 hypothetical protein; Provisional; Region: PRK11677 481805001543 Predicted ATPase [General function prediction only]; Region: COG1485 481805001544 Ribosomal protein L13. Protein L13, a large ribosomal subunit protein, is one of five proteins required for an early folding intermediate of 23S rRNA in the assembly of the large subunit. L13 is situated on the bottom of the large subunit, near the...; Region: Ribosomal_L13; cd00392 481805001545 23S rRNA interface [nucleotide binding]; other site 481805001546 L3 interface [polypeptide binding]; other site 481805001547 30S ribosomal protein S9; Reviewed; Region: rpsI; PRK00132 481805001548 stringent starvation protein A; Provisional; Region: sspA; PRK09481 481805001549 GST_N family, Stringent starvation protein A (SspA) subfamily; SspA is a RNA polymerase (RNAP)-associated protein required for the lytic development of phage P1 and for stationary phase-induced acid tolerance of E. coli. It is implicated in survival...; Region: GST_N_SspA; cd03059 481805001550 C-terminal domain interface [polypeptide binding]; other site 481805001551 putative GSH binding site (G-site) [chemical binding]; other site 481805001552 dimer interface [polypeptide binding]; other site 481805001553 C-terminal, alpha helical domain of Stringent starvation protein A; Region: GST_C_SspA; cd03186 481805001554 dimer interface [polypeptide binding]; other site 481805001555 N-terminal domain interface [polypeptide binding]; other site 481805001556 ClpXP protease specificity-enhancing factor; Provisional; Region: PRK11798 481805001557 putative cryptic C4-dicarboxylate transporter DcuD; Provisional; Region: PRK09804 481805001558 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 481805001559 transcriptional regulator NanR; Provisional; Region: PRK03837 481805001560 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805001561 DNA-binding site [nucleotide binding]; DNA binding site 481805001562 FCD domain; Region: FCD; pfam07729 481805001563 N-acetylneuraminate lyase; Region: nanA; TIGR00683 481805001564 N-Acetylneuraminic acid aldolase, also called N-acetylneuraminate lyase (NAL); Region: NAL; cd00954 481805001565 inhibitor site; inhibition site 481805001566 active site 481805001567 dimer interface [polypeptide binding]; other site 481805001568 catalytic residue [active] 481805001569 putative sialic acid transporter; Provisional; Region: PRK03893 481805001570 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805001571 putative substrate translocation pore; other site 481805001572 Putative N-acetylmannosamine-6-phosphate epimerase [Carbohydrate transport and metabolism]; Region: NanE; COG3010 481805001573 N-acetylmannosamine-6-phosphate epimerase (NanE) converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate. This reaction is part of the pathway that allows the usage of sialic acid as a carbohydrate source. Sialic acids are a family of...; Region: NanE; cd04729 481805001574 putative active site cavity [active] 481805001575 N-acetylmannosamine kinase; Provisional; Region: PRK05082 481805001576 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481805001577 nucleotide binding site [chemical binding]; other site 481805001578 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 481805001579 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 481805001580 Protein of unknown function (DUF1016); Region: DUF1016; pfam06250 481805001581 glutamate synthase small subunit family protein, proteobacterial; Region: gltD_gamma_fam; TIGR01318 481805001582 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481805001583 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805001584 glutamate synthase subunit alpha; Provisional; Region: gltB; PRK11750 481805001585 Glutamine amidotransferases class-II (Gn-AT), glutamate synthase (GltS)-type. GltS is a homodimer that synthesizes L-glutamate from 2-oxoglutarate and L-glutamine, an important step in ammonia assimilation in bacteria, cyanobacteria and plants. The...; Region: GltS; cd00713 481805001586 active site 481805001587 dimer interface [polypeptide binding]; other site 481805001588 Glutamate synthase central domain; Region: Glu_syn_central; pfam04898 481805001589 Glutamate synthase (GltS) FMN-binding domain. GltS is a complex iron-sulfur flavoprotein that catalyzes the reductive synthesis of L-glutamate from 2-oxoglutarate and L-glutamine via intramolecular channelling of ammonia, a reaction in the plant, yeast...; Region: GltS_FMN; cd02808 481805001590 active site 481805001591 FMN binding site [chemical binding]; other site 481805001592 substrate binding site [chemical binding]; other site 481805001593 3Fe-4S cluster binding site [ion binding]; other site 481805001594 gltb_C. This domain is found at the C-terminus of the large subunit (gltB) of glutamate synthase (GltS). GltS encodes a complex iron-sulfur flavoprotein that catalyzes the synthesis of L-glutamate from L-glutamine and 2-oxoglutarate. It requires the...; Region: gltB_C; cd00982 481805001595 domain interface; other site 481805001596 radical SAM protein, TIGR01212 family; Region: TIGR01212 481805001597 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805001598 FeS/SAM binding site; other site 481805001599 aerobic respiration control sensor protein ArcB; Provisional; Region: PRK11091 481805001600 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481805001601 putative active site [active] 481805001602 heme pocket [chemical binding]; other site 481805001603 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805001604 dimer interface [polypeptide binding]; other site 481805001605 phosphorylation site [posttranslational modification] 481805001606 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805001607 ATP binding site [chemical binding]; other site 481805001608 Mg2+ binding site [ion binding]; other site 481805001609 G-X-G motif; other site 481805001610 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805001611 active site 481805001612 phosphorylation site [posttranslational modification] 481805001613 intermolecular recognition site; other site 481805001614 dimerization interface [polypeptide binding]; other site 481805001615 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 481805001616 putative binding surface; other site 481805001617 active site 481805001618 isoprenoid biosynthesis protein with amidotransferase-like domain; Provisional; Region: PRK11780 481805001619 Type 1 glutamine amidotransferase (GATase1)-like domain found in zebrafish ES1; Region: GATase1_ES1; cd03133 481805001620 conserved cys residue [active] 481805001621 monofunctional biosynthetic peptidoglycan transglycosylase; Provisional; Region: mtgA; PRK00056 481805001622 Transglycosylase; Region: Transgly; cl17702 481805001623 hypothetical protein; Provisional; Region: PRK10345 481805001624 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 481805001625 dimerization domain swap beta strand [polypeptide binding]; other site 481805001626 regulatory protein interface [polypeptide binding]; other site 481805001627 active site 481805001628 regulatory phosphorylation site [posttranslational modification]; other site 481805001629 P-loop ATPase protein family; Region: ATP_bind_2; pfam03668 481805001630 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481805001631 active site 481805001632 phosphorylation site [posttranslational modification] 481805001633 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 481805001634 30S subunit binding site; other site 481805001635 RNA polymerase factor sigma-54; Reviewed; Region: PRK05932 481805001636 Sigma-54 factor, Activator interacting domain (AID); Region: Sigma54_AID; pfam00309 481805001637 Sigma-54 factor, core binding domain; Region: Sigma54_CBD; pfam04963 481805001638 Sigma-54, DNA binding domain; Region: Sigma54_DBD; pfam04552 481805001639 lipopolysaccharide ABC transporter ATP-binding protein; Provisional; Region: PRK10895 481805001640 ATP-binding cassette component of YhbG transport system; Region: ABC_YhbG; cd03218 481805001641 Walker A/P-loop; other site 481805001642 ATP binding site [chemical binding]; other site 481805001643 Q-loop/lid; other site 481805001644 ABC transporter signature motif; other site 481805001645 Walker B; other site 481805001646 D-loop; other site 481805001647 H-loop/switch region; other site 481805001648 lipopolysaccharide transport periplasmic protein LptA; Provisional; Region: PRK10894 481805001649 lipopolysaccharide transport periplasmic protein LptA; Region: outer_YhbN_LptA; TIGR03002 481805001650 lipopolysaccharide exporter periplasmic protein; Provisional; Region: PRK10893 481805001651 Lipopolysaccharide-assembly, LptC-related; Region: LptC; pfam06835 481805001652 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase; Provisional; Region: PRK09484 481805001653 HAD-superfamily hydrolase, subfamily IIIA; Region: HAD-SF-IIIA; TIGR01662 481805001654 D-arabinose 5-phosphate isomerase; Provisional; Region: PRK10892 481805001655 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 481805001656 putative active site [active] 481805001657 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 481805001658 putative calcium/sodium:proton antiporter; Provisional; Region: PRK10734 481805001659 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 481805001660 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 481805001661 putative ABC transporter ATP-binding protein YrbF; Provisional; Region: PRK11831 481805001662 ATP-binding cassette transport system involved in resistant to organic solvents; Region: ABC_Org_Solvent_Resistant; cd03261 481805001663 Walker A/P-loop; other site 481805001664 ATP binding site [chemical binding]; other site 481805001665 Q-loop/lid; other site 481805001666 ABC transporter signature motif; other site 481805001667 Walker B; other site 481805001668 D-loop; other site 481805001669 H-loop/switch region; other site 481805001670 ABC-type transport system involved in resistance to organic solvents, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2B; COG0767 481805001671 conserved hypothetical integral membrane protein; Region: TIGR00056 481805001672 ABC-type transport system involved in resistance to organic solvents, periplasmic component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: Ttg2C; COG1463 481805001673 mce related protein; Region: MCE; pfam02470 481805001674 ABC transporter periplasmic binding protein MlaC; Provisional; Region: PRK15117 481805001675 Sulphate Transporter and Anti-Sigma factor antagonist) domain of anti-anti-sigma factors, key regulators of anti-sigma factors by phosphorylation; Region: STAS_anti-anti-sigma_factors; cd07043 481805001676 anti sigma factor interaction site; other site 481805001677 regulatory phosphorylation site [posttranslational modification]; other site 481805001678 Predicted transcriptional regulator, BolA superfamily [Transcription]; Region: COG5007 481805001679 UDP-N-acetylglucosamine 1-carboxyvinyltransferase; Region: murA; TIGR01072 481805001680 UDP-N-acetylglucosamine enolpyruvyl transferase catalyzes enolpyruvyl transfer as part of the first step in the biosynthesis of peptidoglycan, a component of the bacterial cell wall. The reaction is phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine =...; Region: UdpNAET; cd01555 481805001681 hinge; other site 481805001682 active site 481805001683 DNA-binding transcriptional regulator Nlp; Provisional; Region: PRK10344 481805001684 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 481805001685 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 481805001686 substrate binding pocket [chemical binding]; other site 481805001687 chain length determination region; other site 481805001688 substrate-Mg2+ binding site; other site 481805001689 catalytic residues [active] 481805001690 aspartate-rich region 1; other site 481805001691 active site lid residues [active] 481805001692 aspartate-rich region 2; other site 481805001693 50S ribosomal protein L21/unknown domain fusion protein; Provisional; Region: PRK12278 481805001694 50S ribosomal protein L21; Validated; Region: rplU; PRK05573 481805001695 50S ribosomal protein L27; Validated; Region: rpmA; PRK05435 481805001696 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 481805001697 EamA-like transporter family; Region: EamA; pfam00892 481805001698 EamA-like transporter family; Region: EamA; pfam00892 481805001699 GTPase CgtA; Reviewed; Region: obgE; PRK12298 481805001700 GTP1/OBG; Region: GTP1_OBG; pfam01018 481805001701 Obg GTPase; Region: Obg; cd01898 481805001702 G1 box; other site 481805001703 GTP/Mg2+ binding site [chemical binding]; other site 481805001704 Switch I region; other site 481805001705 G2 box; other site 481805001706 G3 box; other site 481805001707 Switch II region; other site 481805001708 G4 box; other site 481805001709 G5 box; other site 481805001710 D-alanyl-D-alanine carboxypeptidase/endopeptidase; Provisional; Region: PRK11113 481805001711 D-alanyl-D-alanine carboxypeptidase, serine-type, PBP4 family; Region: PBP4; TIGR00666 481805001712 transcription elongation factor GreA; Reviewed; Region: greA; PRK00226 481805001713 Transcription elongation factor, N-terminal; Region: GreA_GreB_N; pfam03449 481805001714 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 481805001715 RNA-binding protein YhbY; Provisional; Region: PRK10343 481805001716 23S rRNA methylase [Translation, ribosomal structure and biogenesis]; Region: FtsJ; COG0293 481805001717 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805001718 S-adenosylmethionine binding site [chemical binding]; other site 481805001719 ATP-dependent metalloprotease; Reviewed; Region: hflB; PRK10733 481805001720 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805001721 Walker A motif; other site 481805001722 ATP binding site [chemical binding]; other site 481805001723 Walker B motif; other site 481805001724 arginine finger; other site 481805001725 Peptidase family M41; Region: Peptidase_M41; pfam01434 481805001726 DHPS subgroup of Pterin binding enzymes. DHPS (dihydropteroate synthase), a functional homodimer, catalyzes the condensation of p-aminobenzoic acid (pABA) in the de novo biosynthesis of folate, which is an essential cofactor in both nucleic acid and...; Region: DHPS; cd00739 481805001727 dihydropteroate synthase; Region: DHPS; TIGR01496 481805001728 substrate binding pocket [chemical binding]; other site 481805001729 dimer interface [polypeptide binding]; other site 481805001730 inhibitor binding site; inhibition site 481805001731 phosphoglucosamine mutase; Provisional; Region: glmM; PRK10887 481805001732 GlmM is a bacterial phosphoglucosamine mutase (PNGM) that belongs to the alpha-D-phosphohexomutase superfamily. It is required for the interconversion of glucosamine-6-phosphate and glucosamine-1-phosphate in the biosynthetic pathway of...; Region: GlmM; cd05802 481805001733 active site 481805001734 substrate binding site [chemical binding]; other site 481805001735 metal binding site [ion binding]; metal-binding site 481805001736 Preprotein translocase SecG subunit; Region: SecG; pfam03840 481805001737 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 481805001738 Sulfatase; Region: Sulfatase; pfam00884 481805001739 argininosuccinate synthase; Validated; Region: PRK05370 481805001740 ribosome maturation protein RimP; Reviewed; Region: PRK00092 481805001741 Sm and related proteins; Region: Sm_like; cl00259 481805001742 Bacillus subtilis YxlS-like, C-terminal domain; Region: YlxS_C; cd01734 481805001743 putative oligomer interface [polypeptide binding]; other site 481805001744 putative RNA binding site [nucleotide binding]; other site 481805001745 transcription elongation factor NusA; Validated; Region: nusA; PRK09202 481805001746 NusA N-terminal domain; Region: NusA_N; pfam08529 481805001747 S1_NusA: N-utilizing substance A protein (NusA), S1-like RNA-binding domain. S1-like RNA-binding domains are found in a wide variety of RNA-associated proteins. NusA is a transcription elongation factor containing an N-terminal catalytic domain and three...; Region: S1_NusA; cd04455 481805001748 RNA binding site [nucleotide binding]; other site 481805001749 homodimer interface [polypeptide binding]; other site 481805001750 NusA-like KH domain; Region: KH_5; pfam13184 481805001751 NusA_K homology RNA-binding domain (KH). NusA is an essential multifunctional transcription elongation factor that is universally conserved among prokaryotes and archaea. NusA anti-termination function plays an important role in the expression of...; Region: NusA_KH; cd02134 481805001752 G-X-X-G motif; other site 481805001753 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 481805001754 transcription termination factor NusA, C-terminal duplication; Region: nusA_Cterm_rpt; TIGR01954 481805001755 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 481805001756 Bacterial translation initiation factor IF-2 associated region; Region: IF2_assoc; pfam08364 481805001757 translation initiation factor IF-2; Region: IF-2; TIGR00487 481805001758 Translation initiation factor IF-2, N-terminal region; Region: IF2_N; pfam04760 481805001759 Initiation Factor 2 (IF2)/ eukaryotic Initiation Factor 5B (eIF5B) family; Region: IF2_eIF5B; cd01887 481805001760 G1 box; other site 481805001761 putative GEF interaction site [polypeptide binding]; other site 481805001762 GTP/Mg2+ binding site [chemical binding]; other site 481805001763 Switch I region; other site 481805001764 G2 box; other site 481805001765 G3 box; other site 481805001766 Switch II region; other site 481805001767 G4 box; other site 481805001768 G5 box; other site 481805001769 This family represents the domain II of bacterial Initiation Factor 2 (IF2) and its eukaryotic mitochondrial homologue mtIF2. IF2, the largest initiation factor is an essential GTP binding protein. In E. coli three natural forms of IF2 exist in the cell; Region: IF2_mtIF2_II; cd03702 481805001770 Translation-initiation factor 2; Region: IF-2; pfam11987 481805001771 mtIF2_IVc: this family represents the C2 subdomain of domain IV of mitochondrial translation initiation factor 2 (mtIF2) which adopts a beta-barrel fold displaying a high degree of structural similarity with domain II of the translation elongation factor...; Region: mtIF2_IVc; cd03692 481805001772 ribosome-binding factor A; Validated; Region: rbfA; PRK00521 481805001773 tRNA pseudouridine synthase B; Provisional; Region: truB; PRK05033 481805001774 Pseudouridine synthase, Escherichia coli TruB like; Region: PseudoU_synth_EcTruB; cd02573 481805001775 RNA binding site [nucleotide binding]; other site 481805001776 active site 481805001777 Pseudouridine synthase II TruB, C-terminal; Region: TruB-C_2; pfam09157 481805001778 Ribosomal protein S15 (prokaryotic)_S13 (eukaryotic) binds the central domain of 16S rRNA and is required for assembly of the small ribosomal subunit and for intersubunit association, thus representing a key element in the assembly of the whole ribosome; Region: Ribosomal_S15p_S13e; cd00353 481805001779 16S/18S rRNA binding site [nucleotide binding]; other site 481805001780 S13e-L30e interaction site [polypeptide binding]; other site 481805001781 25S rRNA binding site [nucleotide binding]; other site 481805001782 polynucleotide phosphorylase/polyadenylase; Provisional; Region: PRK11824 481805001783 Polyribonucleotide nucleotidyltransferase, repeat 1; Region: RNase_PH_PNPase_1; cd11363 481805001784 RNase E interface [polypeptide binding]; other site 481805001785 trimer interface [polypeptide binding]; other site 481805001786 Polyribonucleotide nucleotidyltransferase, RNA binding domain; Region: PNPase; pfam03726 481805001787 Polyribonucleotide nucleotidyltransferase, repeat 2; Region: RNase_PH_PNPase_2; cd11364 481805001788 RNase E interface [polypeptide binding]; other site 481805001789 trimer interface [polypeptide binding]; other site 481805001790 active site 481805001791 Polynucleotide phosphorylase (PNPase) K homology RNA-binding domain (KH). PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA in prokaryotes and plant chloroplasts. The C-terminal region of PNPase contains domains homologous to...; Region: PNPase_KH; cd02393 481805001792 putative nucleic acid binding region [nucleotide binding]; other site 481805001793 G-X-X-G motif; other site 481805001794 S1_PNPase: Polynucleotide phosphorylase (PNPase), ), S1-like RNA-binding domain. PNPase is a polyribonucleotide nucleotidyl transferase that degrades mRNA. It is a trimeric multidomain protein. The C-terminus contains the S1 domain which binds ssRNA; Region: S1_PNPase; cd04472 481805001795 RNA binding site [nucleotide binding]; other site 481805001796 domain interface; other site 481805001797 lipoprotein NlpI; Provisional; Region: PRK11189 481805001798 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481805001799 binding surface 481805001800 TPR motif; other site 481805001801 ATP-dependent RNA helicase DeaD; Provisional; Region: PRK11634 481805001802 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 481805001803 ATP binding site [chemical binding]; other site 481805001804 Mg++ binding site [ion binding]; other site 481805001805 motif III; other site 481805001806 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805001807 nucleotide binding region [chemical binding]; other site 481805001808 ATP-binding site [chemical binding]; other site 481805001809 RNA recognition motif in Escherichia coli cold-shock DEAD box protein A (CsdA) and similar proteins; Region: RRM_EcCsdA_like; cd12499 481805001810 putative RNA binding site [nucleotide binding]; other site 481805001811 tryptophan permease; Provisional; Region: PRK10483 481805001812 aromatic amino acid transport protein; Region: araaP; TIGR00837 481805001813 hypothetical protein; Provisional; Region: PRK10508 481805001814 Flavin-utilizing monoxygenases; Region: Flavin_utilizing_monoxygenases; cl07892 481805001815 putative protease; Provisional; Region: PRK15447 481805001816 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 481805001817 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 481805001818 Peptidase family U32; Region: Peptidase_U32; pfam01136 481805001819 Putative lipid carrier protein [Lipid metabolism]; Region: COG3154 481805001820 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 481805001821 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481805001822 Coenzyme A binding pocket [chemical binding]; other site 481805001823 The GIY-YIG domain of uncharacterized protein family UPF0213 related to structure-specific endonuclease SLX1; Region: GIY-YIG_UPF0213; cd10456 481805001824 GIY-YIG motif/motif A; other site 481805001825 putative active site [active] 481805001826 putative metal binding site [ion binding]; other site 481805001827 hypothetical protein; Provisional; Region: PRK03467 481805001828 intracellular protease, PfpI family; Region: PfpI; TIGR01382 481805001829 A type 1 glutamine amidotransferase (GATase1)-like domain found in PfpI from Pyrococcus furiosus; Region: GATase1_PfpI_like; cd03134 481805001830 proposed catalytic triad [active] 481805001831 conserved cys residue [active] 481805001832 CC3(TIP30)-like, atypical (a) SDRs; Region: CC3_like_SDR_a; cd05250 481805001833 NADH(P)-binding; Region: NAD_binding_10; pfam13460 481805001834 NAD binding site [chemical binding]; other site 481805001835 active site 481805001836 Predicted permease; Region: DUF318; pfam03773 481805001837 outer membrane lipoprotein; Provisional; Region: PRK11023 481805001838 BON domain; Region: BON; pfam04972 481805001839 BON domain; Region: BON; pfam04972 481805001840 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 481805001841 dimer interface [polypeptide binding]; other site 481805001842 active site 481805001843 TIGR00252 family protein; Region: TIGR00252 481805001844 Type 1 periplasmic binding fold superfamily; Region: Periplasmic_Binding_Protein_Type_1; cl10011 481805001845 Putative lipoprotein [General function prediction only]; Region: LppC; COG3107 481805001846 Periplasmic binding component of lipoprotein LppC, an immunodominant antigen; Region: PBP1_YraM_LppC_lipoprotein_like; cd06339 481805001847 putative ligand binding site [chemical binding]; other site 481805001848 SAM-dependent 16S ribosomal RNA C1402 ribose 2'-O-methyltransferase; Provisional; Region: PRK14994 481805001849 Ribosomal RNA small subunit methyltransferase I, also known as rRNA (cytidine-2'-O-)-methyltransferase RsmI; Region: RsmI; cd11648 481805001850 putative SAM binding site [chemical binding]; other site 481805001851 putative homodimer interface [polypeptide binding]; other site 481805001852 Fimbrial protein; Region: Fimbrial; pfam00419 481805001853 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 481805001854 PapC N-terminal domain; Region: PapC_N; pfam13954 481805001855 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 481805001856 PapC C-terminal domain; Region: PapC_C; pfam13953 481805001857 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 481805001858 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 481805001859 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 481805001860 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 481805001861 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 481805001862 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 481805001863 active site 481805001864 trimer interface [polypeptide binding]; other site 481805001865 allosteric site; other site 481805001866 active site lid [active] 481805001867 PTS system N-acetylgalactosamine-specific transporter subunit IID; Provisional; Region: PRK09855 481805001868 PTS system N-acetylgalactosamine-specific transporter subunit IIC; Provisional; Region: PRK09757 481805001869 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 481805001870 active site 481805001871 phosphorylation site [posttranslational modification] 481805001872 Fructose/tagarose-bisphosphate aldolase class II. This family includes fructose-1,6-bisphosphate (FBP) and tagarose 1,6-bisphosphate (TBP) aldolases. FBP-aldolase is homodimeric and used in gluconeogenesis and glycolysis; the enzyme controls the...; Region: FTBP_aldolase_II; cd00453 481805001873 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 481805001874 active site 481805001875 intersubunit interface [polypeptide binding]; other site 481805001876 zinc binding site [ion binding]; other site 481805001877 Na+ binding site [ion binding]; other site 481805001878 putative sugar isomerase, AgaS family; Region: agaS_fam; TIGR02815 481805001879 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 481805001880 dimer interface [polypeptide binding]; other site 481805001881 active site 481805001882 AgaS-like protein. AgaS contains a SIS (Sugar ISomerase) domain which is found in many phosphosugar isomerases and phosphosugar binding proteins. AgaS is a putative isomerase in Escherichia coli. It is similar to the glucosamine-6-phosphate synthases; Region: SIS_AgaS_like; cd05010 481805001883 putative active site [active] 481805001884 N-acetylglucosamine-6-phosphate deacetylase [Carbohydrate transport and metabolism]; Region: NagA; COG1820 481805001885 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 481805001886 active site 481805001887 dimer interface [polypeptide binding]; other site 481805001888 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 481805001889 active pocket/dimerization site; other site 481805001890 active site 481805001891 phosphorylation site [posttranslational modification] 481805001892 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IID [Carbohydrate transport and metabolism]; Region: ManZ; COG3716 481805001893 Phosphotransferase system, mannose/fructose/N-acetylgalactosamine-specific component IIC [Carbohydrate transport and metabolism]; Region: ManY; COG3715 481805001894 PTS_IIB, PTS system, Mannose/sorbose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_man; cd00001 481805001895 active site 481805001896 phosphorylation site [posttranslational modification] 481805001897 tagatose 6-phosphate aldolase subunit KbaZ; Provisional; Region: PRK15458 481805001898 DNA-binding transcriptional regulator AgaR; Provisional; Region: PRK09802 481805001899 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 481805001900 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481805001901 Toxin with endonuclease activity YhaV; Region: Toxin_YhaV; pfam11663 481805001902 putative regulator PrlF; Provisional; Region: PRK09974 481805001903 Regulators of stationary/sporulation gene expression [Transcription]; Region: AbrB; COG2002 481805001904 galactarate dehydratase; Region: galactar-dH20; TIGR03248 481805001905 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 481805001906 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 481805001907 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805001908 D-galactonate transporter; Region: 2A0114; TIGR00893 481805001909 putative substrate translocation pore; other site 481805001910 alpha-dehydro-beta-deoxy-D-glucarate aldolase; Provisional; Region: PRK10558 481805001911 tartronate semialdehyde reductase; Provisional; Region: garR; PRK11559 481805001912 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 481805001913 glycerate kinase I; Provisional; Region: PRK10342 481805001914 DNA-binding transcriptional activator TdcR; Provisional; Region: PRK11424 481805001915 DNA-binding transcriptional activator TdcA; Provisional; Region: PRK10341 481805001916 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805001917 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 481805001918 putative substrate binding pocket [chemical binding]; other site 481805001919 putative dimerization interface [polypeptide binding]; other site 481805001920 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 481805001921 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 481805001922 tetramer interface [polypeptide binding]; other site 481805001923 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805001924 catalytic residue [active] 481805001925 threonine/serine transporter TdcC; Provisional; Region: PRK13629 481805001926 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 481805001927 propionate/acetate kinase; Provisional; Region: PRK12379 481805001928 Acetokinase family; Region: Acetate_kinase; cl17229 481805001929 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 481805001930 Pyruvate formate lyase 1; Region: PFL1; cd01678 481805001931 coenzyme A binding site [chemical binding]; other site 481805001932 active site 481805001933 catalytic residues [active] 481805001934 glycine loop; other site 481805001935 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 481805001936 homotrimer interaction site [polypeptide binding]; other site 481805001937 putative active site [active] 481805001938 L-serine dehydratase TdcG; Provisional; Region: PRK15040 481805001939 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 481805001940 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 481805001941 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 481805001942 serine transporter; Region: stp; TIGR00814 481805001943 L-cysteine desulfidase [Amino acid transport and metabolism]; Region: COG3681 481805001944 Pirin-related protein [General function prediction only]; Region: COG1741 481805001945 Pirin; Region: Pirin; pfam02678 481805001946 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805001947 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 481805001948 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481805001949 dimerization interface [polypeptide binding]; other site 481805001950 Predicted membrane protein [Function unknown]; Region: COG3152 481805001951 Predicted membrane protein [Function unknown]; Region: COG3152 481805001952 Predicted glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: ECM4; COG0435 481805001953 Glutathione S-transferase, N-terminal domain; Region: GST_N_2; pfam13409 481805001954 C-terminal, alpha helical domain of Class Omega-like Glutathione S-transferases; Region: GST_C_Omega_like; cd03190 481805001955 putative dimer interface [polypeptide binding]; other site 481805001956 N-terminal domain interface [polypeptide binding]; other site 481805001957 putative substrate binding pocket (H-site) [chemical binding]; other site 481805001958 Predicted membrane protein [Function unknown]; Region: COG2259 481805001959 YqjK-like protein; Region: YqjK; pfam13997 481805001960 Predicted membrane protein [Function unknown]; Region: COG5393 481805001961 Uncharacterized conserved protein [Function unknown]; Region: ElaB; COG4575 481805001962 Protein of unknown function (DUF1090); Region: DUF1090; pfam06476 481805001963 EnvZ/OmpR regulon moderator; Provisional; Region: PRK10629 481805001964 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 481805001965 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 481805001966 DNA-binding transcriptional repressor ExuR; Provisional; Region: PRK11523 481805001967 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805001968 DNA-binding site [nucleotide binding]; DNA binding site 481805001969 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 481805001970 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 481805001971 putative fimbrial protein TcfA; Provisional; Region: PRK15308 481805001972 CS1 type fimbrial major subunit; Region: Fimbrial_CS1; pfam04449 481805001973 fimbrial outer membrane usher protein TcfC; Provisional; Region: PRK15310 481805001974 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 481805001975 CblD like pilus biogenesis initiator; Region: CblD; cl06460 481805001976 D-galactonate transporter; Region: 2A0114; TIGR00893 481805001977 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805001978 putative substrate translocation pore; other site 481805001979 Glucuronate isomerase; Region: UxaC; pfam02614 481805001980 Glucuronate isomerase [Carbohydrate transport and metabolism]; Region: UxaC; COG1904 481805001981 Domains similar to fish antifreeze type III protein; Region: SAF_AH_GD; cd11613 481805001982 galactarate dehydratase; Region: galactar-dH20; TIGR03248 481805001983 D-galactarate dehydratase / Altronate hydrolase, C terminus; Region: GD_AH_C; pfam04295 481805001984 Bacterial inner membrane protein; Region: Imp-YgjV; pfam10688 481805001985 serine/threonine transporter SstT; Provisional; Region: PRK13628 481805001986 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 481805001987 integral membrane protein, TerC family; Region: R_switched_Alx; TIGR03718 481805001988 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481805001989 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481805001990 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481805001991 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 481805001992 putative active site [active] 481805001993 Predicted metal-dependent hydrolase [General function prediction only]; Region: COG1451 481805001994 SAM-dependent 23S ribosomal RNA mG1835 methyltransferase; Provisional; Region: PRK15001 481805001995 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805001996 S-adenosylmethionine binding site [chemical binding]; other site 481805001997 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4680 481805001998 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805001999 non-specific DNA binding site [nucleotide binding]; other site 481805002000 salt bridge; other site 481805002001 sequence-specific DNA binding site [nucleotide binding]; other site 481805002002 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 481805002003 2,4-dienoyl-CoA reductase (DCR) FMN-binding domain. DCR in E. coli is an iron-sulfur flavoenzyme which contains FMN, FAD, and a 4Fe-4S cluster. It is also a monomer, unlike that of its eukaryotic counterparts which form homotetramers and lack the...; Region: DCR_FMN; cd02930 481805002004 active site 481805002005 FMN binding site [chemical binding]; other site 481805002006 2,4-decadienoyl-CoA binding site; other site 481805002007 catalytic residue [active] 481805002008 4Fe-4S cluster binding site [ion binding]; other site 481805002009 Uncharacterized NAD(FAD)-dependent dehydrogenases [General function prediction only]; Region: HcaD; COG0446 481805002010 alpha-glucosidase; Provisional; Region: PRK10137 481805002011 Protein of unknown function, DUF608; Region: DUF608; pfam04685 481805002012 Trehalase; Region: Trehalase; cl17346 481805002013 inner membrane transporter YjeM; Provisional; Region: PRK15238 481805002014 cryptic beta-D-galactosidase subunit beta; Reviewed; Region: ebgC; PRK10202 481805002015 cryptic beta-D-galactosidase subunit alpha; Reviewed; Region: ebgA; PRK10340 481805002016 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481805002017 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481805002018 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481805002019 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 481805002020 DNA-binding transcriptional repressor EbgR; Provisional; Region: PRK10339 481805002021 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481805002022 DNA binding site [nucleotide binding] 481805002023 domain linker motif; other site 481805002024 Ligand-binding domain of DNA transcription repressor GalR which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalR; cd01544 481805002025 putative dimerization interface [polypeptide binding]; other site 481805002026 putative ligand binding site [chemical binding]; other site 481805002027 tRNA-binding-domain-containing CsaA-like proteins. CsaA is a molecular chaperone with export related activities. CsaA has a putative tRNA binding activity. The functional unit of CsaA is a homodimer and this domain acts as a dimerization domain; Region: tRNA_bind_CsaA; cd02798 481805002028 dimer interface [polypeptide binding]; other site 481805002029 putative tRNA-binding site [nucleotide binding]; other site 481805002030 putrescine--2-oxoglutarate aminotransferase; Provisional; Region: PRK11522 481805002031 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 481805002032 inhibitor-cofactor binding pocket; inhibition site 481805002033 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805002034 catalytic residue [active] 481805002035 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481805002036 PAS fold; Region: PAS_3; pfam08447 481805002037 putative active site [active] 481805002038 heme pocket [chemical binding]; other site 481805002039 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 481805002040 Methyl-accepting chemotaxis-like domains (chemotaxis sensory transducer); Region: MA; smart00283 481805002041 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481805002042 dimer interface [polypeptide binding]; other site 481805002043 putative CheW interface [polypeptide binding]; other site 481805002044 Predicted transcriptional regulators [Transcription]; Region: COG1695 481805002045 Transcriptional regulator PadR-like family; Region: PadR; pfam03551 481805002046 Siderophore-interacting protein [Inorganic ion transport and metabolism]; Region: ViuB; COG2375 481805002047 Siderophore interacting proteins share the domain structure of the ferredoxin reductase like family. Siderophores are produced in various bacteria (and some plants) to extract iron from hosts. Binding constants are high, so iron can be pilfered from...; Region: siderophore_interacting; cd06193 481805002048 FAD binding pocket [chemical binding]; other site 481805002049 FAD binding motif [chemical binding]; other site 481805002050 phosphate binding motif [ion binding]; other site 481805002051 NAD binding pocket [chemical binding]; other site 481805002052 G:T/U mismatch specific DNA glcosylase (MUG); Region: UDG_F2_MUG; cd10028 481805002053 active site 481805002054 SUMO-1 interface [polypeptide binding]; other site 481805002055 RNA polymerase sigma factor RpoD; Validated; Region: PRK05658 481805002056 Sigma-70 factor, region 1.1; Region: Sigma70_r1_1; pfam03979 481805002057 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 481805002058 Sigma-70, non-essential region; Region: Sigma70_ner; pfam04546 481805002059 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481805002060 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 481805002061 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481805002062 DNA binding residues [nucleotide binding] 481805002063 DNA primase; Validated; Region: dnaG; PRK05667 481805002064 CHC2 zinc finger; Region: zf-CHC2; pfam01807 481805002065 DNA primase catalytic core, N-terminal domain; Region: Toprim_N; pfam08275 481805002066 TOPRIM_DnaG_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of proteins similar to Escherichia coli DnaG. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_DnaG_primases; cd03364 481805002067 active site 481805002068 metal binding site [ion binding]; metal-binding site 481805002069 interdomain interaction site; other site 481805002070 DnaB-helicase binding domain of primase; Region: DnaB_bind; pfam10410 481805002071 DNA primase DnaG DnaB-binding; Region: DnaG_DnaB_bind; pfam08278 481805002072 30S ribosomal protein S21; Reviewed; Region: rpsU; PRK00270 481805002073 UGMP family protein; Validated; Region: PRK09604 481805002074 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214; cl17884 481805002075 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 481805002076 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 481805002077 transmembrane helices; other site 481805002078 L(+)-tartrate dehydratase subunit beta; Validated; Region: PRK08228 481805002079 tartrate dehydratase subunit alpha; Validated; Region: PRK08230 481805002080 transcriptional activator TtdR; Provisional; Region: PRK09801 481805002081 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805002082 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 481805002083 putative effector binding pocket; other site 481805002084 putative dimerization interface [polypeptide binding]; other site 481805002085 putative glycerol-3-phosphate acyltransferase PlsY; Provisional; Region: PRK00220 481805002086 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 481805002087 homooctamer interface [polypeptide binding]; other site 481805002088 active site 481805002089 undecaprenyl pyrophosphate phosphatase; Reviewed; Region: PRK00281 481805002090 multifunctional tRNA nucleotidyl transferase/2'3'-cyclic phosphodiesterase/2'nucleotidase/phosphatase; Reviewed; Region: cca; PRK10885 481805002091 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 481805002092 active site 481805002093 NTP binding site [chemical binding]; other site 481805002094 metal binding triad [ion binding]; metal-binding site 481805002095 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 481805002096 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481805002097 Zn2+ binding site [ion binding]; other site 481805002098 Mg2+ binding site [ion binding]; other site 481805002099 SH3 domain-containing protein; Provisional; Region: PRK10884 481805002100 Bacterial SH3 domain homologues; Region: SH3b; smart00287 481805002101 Uncharacterized conserved protein [Function unknown]; Region: COG3025 481805002102 Uncharacterized subgroup of the CYTH-like superfamily having an associated CHAD domain; Region: CYTH-like_Pase_CHAD; cd07756 481805002103 putative active site [active] 481805002104 putative metal binding residues [ion binding]; other site 481805002105 signature motif; other site 481805002106 putative triphosphate binding site [ion binding]; other site 481805002107 CHAD domain; Region: CHAD; pfam05235 481805002108 bifunctional glutamine-synthetase adenylyltransferase/deadenyltransferase; Reviewed; Region: PRK11072 481805002109 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 481805002110 metal binding triad; other site 481805002111 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 481805002112 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 481805002113 metal binding triad; other site 481805002114 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 481805002115 bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Provisional; Region: PRK11316 481805002116 RfaE encodes a bifunctional ADP-heptose synthase involved in the biosynthesis of the lipopolysaccharide (LPS) core precursor ADP-L-glycero-D-manno-heptose. LPS plays an important role in maintaining the structural integrity of the bacterial outer...; Region: RfaE_like; cd01172 481805002117 putative ribose interaction site [chemical binding]; other site 481805002118 putative ADP binding site [chemical binding]; other site 481805002119 rfaE bifunctional protein, domain II; Region: rfaE_dom_II; TIGR02199 481805002120 active site 481805002121 nucleotide binding site [chemical binding]; other site 481805002122 HIGH motif; other site 481805002123 KMSKS motif; other site 481805002124 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2268 481805002125 Band_7_flotillin: a subgroup of the band 7 domain of flotillin (reggie) like proteins. This subgroup contains proteins similar to stomatin, prohibitin, flotillin, HlfK/C and podicin. These two proteins are lipid raft-associated. Individual proteins of...; Region: Band_7_flotillin; cd03399 481805002126 Protein of unknown function (DUF1449); Region: DUF1449; pfam07290 481805002127 glycogen synthesis protein GlgS; Provisional; Region: PRK02922 481805002128 Fimbrial protein; Region: Fimbrial; pfam00419 481805002129 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 481805002130 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 481805002131 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 481805002132 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 481805002133 PapC N-terminal domain; Region: PapC_N; pfam13954 481805002134 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 481805002135 PapC C-terminal domain; Region: PapC_C; pfam13953 481805002136 putative fimbrial protein; Provisional; Region: PRK09733 481805002137 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2960 481805002138 3,4-dihydroxy-2-butanone 4-phosphate synthase; Provisional; Region: ribB; PRK03353 481805002139 3,4-dihydroxy-2-butanone 4-phosphate synthase [Coenzyme metabolism]; Region: RibB; COG0108 481805002140 Protein of unknown function (DUF4051); Region: DUF4051; pfam13260 481805002141 zinc transporter ZupT; Provisional; Region: PRK04201 481805002142 ZIP Zinc transporter; Region: Zip; pfam02535 481805002143 The Class III extradiol dioxygenase, 4,5-DOPA Dioxygenase, catalyzes the incorporation of both atoms of molecular oxygen into 4,5-dihydroxy-phenylalanine; Region: 45_DOPA_Dioxygenase; cd07363 481805002144 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 481805002145 putative active site [active] 481805002146 metal binding site [ion binding]; metal-binding site 481805002147 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 481805002148 hypothetical protein; Provisional; Region: PRK11653 481805002149 outer membrane channel protein; Reviewed; Region: tolC; PRK09465 481805002150 ADP-ribose pyrophosphatase NudF; Provisional; Region: nudF; PRK10729 481805002151 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 481805002152 dimer interface [polypeptide binding]; other site 481805002153 ADP-ribose binding site [chemical binding]; other site 481805002154 active site 481805002155 nudix motif; other site 481805002156 metal binding site [ion binding]; metal-binding site 481805002157 putative dehydrogenase; Provisional; Region: PRK11039 481805002158 Enterobacter aerogenes GpdQ and related proteins, metallophosphatase domain; Region: MPP_GpdQ; cd07402 481805002159 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481805002160 active site 481805002161 metal binding site [ion binding]; metal-binding site 481805002162 hexamer interface [polypeptide binding]; other site 481805002163 esterase YqiA; Provisional; Region: PRK11071 481805002164 Alpha/beta hydrolase family; Region: Abhydrolase_6; pfam12697 481805002165 DNA topoisomerase IV, B subunit, proteobacterial; Region: parE_Gneg; TIGR01055 481805002166 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805002167 ATP binding site [chemical binding]; other site 481805002168 Mg2+ binding site [ion binding]; other site 481805002169 G-X-G motif; other site 481805002170 TopoIIA_Trans_DNA_gyrase: Transducer domain, having a ribosomal S5 domain 2-like fold, of the type found in proteins of the type IIA family of DNA topoisomerases similar to the B subunits of E. coli DNA gyrase and E. coli Topoisomerase IV which are; Region: TopoII_Trans_DNA_gyrase; cd00822 481805002171 anchoring element; other site 481805002172 dimer interface [polypeptide binding]; other site 481805002173 ATP binding site [chemical binding]; other site 481805002174 Topoisomerase-primase domain. This is a nucleotidyl transferase/hydrolase domain found in type IA, type IIA and type IIB topoisomerases, bacterial DnaG-type primases, small primase-like proteins from bacteria and archaea, OLD family nucleases from...; Region: TOPRIM; cl00718 481805002175 active site 481805002176 metal binding site [ion binding]; metal-binding site 481805002177 DNA gyrase B subunit, carboxyl terminus; Region: DNA_gyraseB_C; pfam00986 481805002178 Uncharacterized conserved protein [Function unknown]; Region: COG1359 481805002179 Putative NADPH-quinone reductase (modulator of drug activity B) [General function prediction only]; Region: MdaB; COG2249 481805002180 sensor protein QseC; Provisional; Region: PRK10337 481805002181 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805002182 dimer interface [polypeptide binding]; other site 481805002183 phosphorylation site [posttranslational modification] 481805002184 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805002185 ATP binding site [chemical binding]; other site 481805002186 Mg2+ binding site [ion binding]; other site 481805002187 G-X-G motif; other site 481805002188 DNA-binding transcriptional regulator QseB; Provisional; Region: PRK10336 481805002189 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805002190 active site 481805002191 phosphorylation site [posttranslational modification] 481805002192 intermolecular recognition site; other site 481805002193 dimerization interface [polypeptide binding]; other site 481805002194 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805002195 DNA binding site [nucleotide binding] 481805002196 TIGR00156 family protein; Region: TIGR00156 481805002197 DNA gyrase inhibitor [DNA replication, recombination, and repair]; Region: COG3449 481805002198 Motility quorum-sensing regulator (MqsR); Region: MqsR; cd12869 481805002199 peptide binding site [polypeptide binding]; other site 481805002200 antitoxin MqsA for MqsR toxin; Region: MqsA; cd12870 481805002201 toxin interface [polypeptide binding]; other site 481805002202 putative zinc finger/helix-turn-helix protein, YgiT family; Region: CxxCG_CxxCG_HTH; TIGR03830 481805002203 Zn binding site [ion binding]; other site 481805002204 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805002205 non-specific DNA binding site [nucleotide binding]; other site 481805002206 salt bridge; other site 481805002207 sequence-specific DNA binding site [nucleotide binding]; other site 481805002208 putative ABC transporter periplasmic-binding protein; Provisional; Region: PRK09755 481805002209 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 481805002210 peptide binding site [polypeptide binding]; other site 481805002211 DNA topoisomerase IV, A subunit, proteobacterial; Region: parC_Gneg; TIGR01062 481805002212 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 481805002213 CAP-like domain; other site 481805002214 active site 481805002215 primary dimer interface [polypeptide binding]; other site 481805002216 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481805002217 1-acyl-sn-glycerol-3-phosphate acyltransferase; Provisional; Region: PRK15018 481805002218 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 481805002219 putative acyl-acceptor binding pocket; other site 481805002220 FtsI repressor; Provisional; Region: PRK10883 481805002221 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 481805002222 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 481805002223 hypothetical protein; Provisional; Region: PRK01254 481805002224 Radical SAM N-terminal; Region: Radical_SAM_N; pfam08497 481805002225 Domain of unknown function (DUF3362); Region: DUF3362; pfam11842 481805002226 putative outer membrane lipoprotein; Provisional; Region: PRK09973 481805002227 Protein of unknown function (DUF3828); Region: DUF3828; pfam12883 481805002228 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481805002229 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481805002230 active site 481805002231 catalytic tetrad [active] 481805002232 Uncharacterized oxidoreductases, Fe-dependent alcohol dehydrogenase family [Energy production and conversion]; Region: COG1979 481805002233 Butanol dehydrogenase catalyzes the conversion of butyraldehyde to butanol with the cofactor NAD(P)H being oxidized in the process; Region: BDH; cd08187 481805002234 dimer interface [polypeptide binding]; other site 481805002235 active site 481805002236 metal binding site [ion binding]; metal-binding site 481805002237 AraC-type transcriptional regulator N-terminus; Region: AraC_N; pfam06719 481805002238 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481805002239 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805002240 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805002241 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 481805002242 SNARE associated Golgi protein; Region: SNARE_assoc; cl00429 481805002243 cystathionine beta-lyase; Provisional; Region: PRK08114 481805002244 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 481805002245 homodimer interface [polypeptide binding]; other site 481805002246 substrate-cofactor binding pocket; other site 481805002247 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805002248 catalytic residue [active] 481805002249 biopolymer transport protein ExbB; Provisional; Region: PRK10414 481805002250 biopolymer transport protein ExbD; Provisional; Region: PRK11267 481805002251 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 481805002252 oxidoreductase; Provisional; Region: PRK07985 481805002253 classical (c) SDR, subgroup 1; Region: SDR_c1; cd05355 481805002254 NAD binding site [chemical binding]; other site 481805002255 metal binding site [ion binding]; metal-binding site 481805002256 active site 481805002257 hypothetical protein; Provisional; Region: PRK05208 481805002258 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481805002259 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481805002260 active site 481805002261 catalytic tetrad [active] 481805002262 Protein of unknown function (DUF2623); Region: DUF2623; pfam11115 481805002263 hydrogenase 2 small subunit; Provisional; Region: PRK10468 481805002264 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 481805002265 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 481805002266 hydrogenase 2 protein HybA; Provisional; Region: PRK10882 481805002267 4Fe-4S binding domain; Region: Fer4_6; pfam12837 481805002268 putative hydrogenase 2 b cytochrome subunit; Provisional; Region: PRK10881 481805002269 Polysulphide reductase, NrfD; Region: NrfD; pfam03916 481805002270 hydrogenase 2 large subunit; Provisional; Region: PRK10467 481805002271 Ni,Fe-hydrogenase I large subunit [Energy production and conversion]; Region: HyaB; COG0374 481805002272 coenzyme F420-reducing hydrogenase delta subunit (putative coenzyme F420 hydrogenase processing subunit); Region: frhD; TIGR00130 481805002273 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 481805002274 putative substrate-binding site; other site 481805002275 nickel binding site [ion binding]; other site 481805002276 hydrogenase 2-specific chaperone; Provisional; Region: PRK10465 481805002277 Zn finger protein HypA/HybF (possibly regulating hydrogenase expression) [General function prediction only]; Region: HybF; COG0375 481805002278 hydrogenase nickel incorporation protein HybF; Provisional; Region: PRK12380 481805002279 hydrogenase 2 accessory protein HypG; Provisional; Region: PRK10413 481805002280 putative S-transferase; Provisional; Region: PRK11752 481805002281 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 481805002282 C-terminal domain interface [polypeptide binding]; other site 481805002283 GSH binding site (G-site) [chemical binding]; other site 481805002284 dimer interface [polypeptide binding]; other site 481805002285 C-terminal, alpha helical domain of Escherichia coli Yghu Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YghU_like; cd10292 481805002286 dimer interface [polypeptide binding]; other site 481805002287 N-terminal domain interface [polypeptide binding]; other site 481805002288 active site 481805002289 bifunctional glutathionylspermidine amidase/glutathionylspermidine synthetase; Provisional; Region: PRK10507 481805002290 CHAP domain; Region: CHAP; pfam05257 481805002291 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 481805002292 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 481805002293 Phosphate/sulphate permeases [Inorganic ion transport and metabolism]; Region: PitA; COG0306 481805002294 Thymidylate kinase [Nucleotide transport and metabolism]; Region: Tmk; COG0125 481805002295 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 481805002296 TMP-binding site; other site 481805002297 ATP-binding site [chemical binding]; other site 481805002298 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 481805002299 TMP-binding site; other site 481805002300 ATP-binding site [chemical binding]; other site 481805002301 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 481805002302 Thymidylate kinase; Region: Thymidylate_kin; pfam02223 481805002303 active site 481805002304 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 481805002305 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 481805002306 Bacterial protein of unknown function (YtfJ_HI0045); Region: YtfJ_HI0045; pfam09695 481805002307 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 481805002308 Predicted permeases [General function prediction only]; Region: COG0795 481805002309 Predicted permeases [General function prediction only]; Region: COG0795; cl12074 481805002310 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 481805002311 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 481805002312 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 481805002313 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 481805002314 catalytic residue [active] 481805002315 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 481805002316 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 481805002317 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481805002318 NAD(P) binding site [chemical binding]; other site 481805002319 active site 481805002320 acyl-CoA synthetase; Validated; Region: PRK09192 481805002321 Fatty acyl-AMP ligase (FAAL); Region: FAAL; cd05931 481805002322 acyl-activating enzyme (AAE) consensus motif; other site 481805002323 active site 481805002324 DNA-binding transcriptional regulator GlcC; Provisional; Region: PRK09990 481805002325 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805002326 DNA-binding site [nucleotide binding]; DNA binding site 481805002327 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 481805002328 glycolate oxidase subunit GlcD; Provisional; Region: PRK11230 481805002329 FAD binding domain; Region: FAD_binding_4; pfam01565 481805002330 glycolate oxidase FAD binding subunit; Provisional; Region: glcE; PRK11282 481805002331 FAD binding domain; Region: FAD_binding_4; pfam01565 481805002332 glycolate oxidase iron-sulfur subunit; Provisional; Region: glcF; PRK11274 481805002333 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 481805002334 Cysteine-rich domain; Region: CCG; pfam02754 481805002335 Cysteine-rich domain; Region: CCG; pfam02754 481805002336 hypothetical protein; Provisional; Region: PRK09732 481805002337 Malate synthase G (MSG), monomeric enzyme present in some bacteria. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to malyl-CoA , which hydrolyzes to malate and CoA. This reaction is part of the glyoxylate...; Region: malate_synt_G; cd00728 481805002338 active site 481805002339 glycolate transporter; Provisional; Region: PRK09695 481805002340 L-lactate permease; Region: Lactate_perm; cl00701 481805002341 Transposase; Region: HTH_Tnp_1; cl17663 481805002342 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 481805002343 putative transposase OrfB; Reviewed; Region: PHA02517 481805002344 HTH-like domain; Region: HTH_21; pfam13276 481805002345 Integrase core domain; Region: rve; pfam00665 481805002346 Integrase core domain; Region: rve_2; pfam13333 481805002347 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481805002348 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481805002349 putative transposase OrfB; Reviewed; Region: PHA02517 481805002350 HTH-like domain; Region: HTH_21; pfam13276 481805002351 Integrase core domain; Region: rve; pfam00665 481805002352 Integrase core domain; Region: rve_2; pfam13333 481805002353 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 481805002354 Transposase; Region: HTH_Tnp_1; pfam01527 481805002355 BCCT family transporter; Region: BCCT; pfam02028 481805002356 putative transposase OrfB; Reviewed; Region: PHA02517 481805002357 Integrase core domain; Region: rve; pfam00665 481805002358 Integrase core domain; Region: rve_3; pfam13683 481805002359 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 481805002360 Helix-turn-helix domain; Region: HTH_38; pfam13936 481805002361 Integrase core domain; Region: rve; pfam00665 481805002362 Predicted dinucleotide-binding enzymes [General function prediction only]; Region: COG2085 481805002363 iron-dicitrate transporter ATP-binding subunit; Provisional; Region: fecE; PRK11231 481805002364 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 481805002365 Walker A/P-loop; other site 481805002366 ATP binding site [chemical binding]; other site 481805002367 Q-loop/lid; other site 481805002368 ABC transporter signature motif; other site 481805002369 Walker B; other site 481805002370 D-loop; other site 481805002371 H-loop/switch region; other site 481805002372 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 481805002373 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481805002374 ABC-ATPase subunit interface; other site 481805002375 dimer interface [polypeptide binding]; other site 481805002376 putative PBP binding regions; other site 481805002377 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 481805002378 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481805002379 dimer interface [polypeptide binding]; other site 481805002380 ABC-ATPase subunit interface; other site 481805002381 putative PBP binding regions; other site 481805002382 iron-dicitrate transporter substrate-binding subunit; Provisional; Region: fecB; PRK11411 481805002383 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 481805002384 siderophore binding site; other site 481805002385 Outer membrane receptor for Fe3+-dicitrate [Inorganic ion transport and metabolism]; Region: FecA; COG4772 481805002386 Secretin and TonB N terminus short domain; Region: STN; smart00965 481805002387 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 481805002388 N-terminal plug; other site 481805002389 ligand-binding site [chemical binding]; other site 481805002390 fec operon regulator FecR; Reviewed; Region: PRK09774 481805002391 FecR protein; Region: FecR; pfam04773 481805002392 RNA polymerase sigma factor FecI; Provisional; Region: PRK09651 481805002393 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481805002394 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481805002395 DNA binding residues [nucleotide binding] 481805002396 integrase; Provisional; Region: PRK09692 481805002397 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 481805002398 active site 481805002399 Int/Topo IB signature motif; other site 481805002400 Uncharacterized membrane protein, possible Na+ channel or pump [General function prediction only]; Region: COG1811 481805002401 ornithine decarboxylase; Provisional; Region: PRK13578 481805002402 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 481805002403 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 481805002404 homodimer interface [polypeptide binding]; other site 481805002405 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805002406 catalytic residue [active] 481805002407 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 481805002408 nucleoside transporter; Region: 2A0110; TIGR00889 481805002409 murein transglycosylase C; Provisional; Region: mltC; PRK11671 481805002410 Domain of unknown function (DUF3393); Region: DUF3393; pfam11873 481805002411 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 481805002412 N-acetyl-D-glucosamine binding site [chemical binding]; other site 481805002413 catalytic residue [active] 481805002414 oxidative damage protection protein; Provisional; Region: PRK05408 481805002415 adenine DNA glycosylase; Provisional; Region: PRK10880 481805002416 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 481805002417 minor groove reading motif; other site 481805002418 helix-hairpin-helix signature motif; other site 481805002419 substrate binding pocket [chemical binding]; other site 481805002420 active site 481805002421 Iron-sulfur binding domain of endonuclease III; Region: EndIII_4Fe-2S; pfam10576 481805002422 DNA glycosylase (MutY in bacteria and hMYH in humans) is responsible for repairing misread A*oxoG residues to C*G by removing the inappropriately paired adenine base from the DNA backbone. It belongs to the Nudix hydrolase superfamily and is important...; Region: DNA_Glycosylase_C; cd03431 481805002423 DNA binding and oxoG recognition site [nucleotide binding] 481805002424 tRNA (guanine-N(7)-)-methyltransferase; Reviewed; Region: trmB; PRK00121 481805002425 hypothetical protein; Provisional; Region: PRK11702 481805002426 hypothetical protein; Provisional; Region: PRK10626 481805002427 Protein of unknown function (DUF2884); Region: DUF2884; pfam11101 481805002428 Bacterial L-asparaginases and related enzymes; Region: L-asparaginase_like; cd00411 481805002429 homodimer interface [polypeptide binding]; other site 481805002430 active site 481805002431 Protein of unknown function (DUF1202); Region: DUF1202; pfam06717 481805002432 HemN family oxidoreductase; Provisional; Region: PRK05660 481805002433 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805002434 FeS/SAM binding site; other site 481805002435 HemN C-terminal domain; Region: HemN_C; pfam06969 481805002436 NTPase/HAM1. This family consists of the HAM1 protein and pyrophosphate-releasing xanthosine/ inosine triphosphatase. HAM1 protects the cell against mutagenesis by the base analog 6-N-hydroxylaminopurine (HAP) in E. Coli and S. cerevisiae. A...; Region: HAM1; cd00515 481805002437 active site 481805002438 dimerization interface [polypeptide binding]; other site 481805002439 hypothetical protein; Validated; Region: PRK05090 481805002440 YGGT family; Region: YGGT; pfam02325 481805002441 YGGT family; Region: YGGT; pfam02325 481805002442 Pyridoxal 5-phosphate (PLP)-binding TIM barrel domain of Type III PLP-Dependent Enzymes, Yggs-like proteins; Region: PLPDE_III_Yggs_like; cd06824 481805002443 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 481805002444 catalytic residue [active] 481805002445 Tfp pilus assembly protein, pilus retraction ATPase PilT [Cell motility and secretion / Intracellular trafficking and secretion]; Region: PilT; COG2805 481805002446 Pilus retraction ATPase PilT. PilT is a nucleotide binding protein responsible for the retraction of type IV pili, likely by pili disassembly. This retraction provides the force required for travel of bacteria in low water environments by a mechanism...; Region: PilT; cd01131 481805002447 Walker A motif; other site 481805002448 ATP binding site [chemical binding]; other site 481805002449 Walker B motif; other site 481805002450 Holliday junction resolvase-like protein; Reviewed; Region: PRK00109 481805002451 hypothetical protein; Validated; Region: PRK00228 481805002452 glutathione synthetase; Provisional; Region: PRK05246 481805002453 Prokaryotic glutathione synthetase, N-terminal domain; Region: GSH-S_N; pfam02951 481805002454 Prokaryotic glutathione synthetase, ATP-grasp domain; Region: GSH-S_ATP; pfam02955 481805002455 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1385 481805002456 RNA methyltransferase, RsmE family; Region: TIGR00046 481805002457 DNA-specific endonuclease I; Provisional; Region: PRK15137 481805002458 Endonuclease I [DNA replication, recombination, and repair]; Region: EndA; COG2356 481805002459 hypothetical protein; Provisional; Region: PRK04860 481805002460 Zn-dependent metalloprotease, SprT family [General function prediction only]; Region: SprT; COG3091 481805002461 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 481805002462 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805002463 putative substrate translocation pore; other site 481805002464 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805002465 S-adenosylmethionine synthetase; Validated; Region: PRK05250 481805002466 S-adenosylmethionine synthetase, N-terminal domain; Region: S-AdoMet_synt_N; pfam00438 481805002467 S-adenosylmethionine synthetase, central domain; Region: S-AdoMet_synt_M; pfam02772 481805002468 S-adenosylmethionine synthetase, C-terminal domain; Region: S-AdoMet_synt_C; pfam02773 481805002469 Arginine decarboxylase (spermidine biosynthesis) [Amino acid transport and metabolism]; Region: SpeA; COG1166 481805002470 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase; Region: PLPDE_III_ADC; cd06830 481805002471 dimer interface [polypeptide binding]; other site 481805002472 active site 481805002473 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 481805002474 catalytic residues [active] 481805002475 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes; Region: PLPDE_III; cl00261 481805002476 Agmatinase-like family includes proclavaminic acid amidinohydrolase; Region: Agmatinase_PAH; cd11592 481805002477 agmatinase; Region: agmatinase; TIGR01230 481805002478 oligomer interface [polypeptide binding]; other site 481805002479 putative active site [active] 481805002480 Mn binding site [ion binding]; other site 481805002481 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 481805002482 transketolase; Reviewed; Region: PRK12753 481805002483 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 481805002484 TPP-binding site [chemical binding]; other site 481805002485 dimer interface [polypeptide binding]; other site 481805002486 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 481805002487 PYR/PP interface [polypeptide binding]; other site 481805002488 dimer interface [polypeptide binding]; other site 481805002489 TPP binding site [chemical binding]; other site 481805002490 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 481805002491 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481805002492 active site 481805002493 phosphorylation site [posttranslational modification] 481805002494 Phosphotransferase system, mannitol-specific IIBC component [Carbohydrate transport and metabolism]; Region: MtlA; COG2213 481805002495 PTS system, mannitol-specific IIC component; Region: mtlA; TIGR00851 481805002496 PTS_IIB_mannitol: subunit IIB of enzyme II (EII) of the mannitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a mannitol-specific permease with two cytoplasmic domains (IIA and IIB) and a transmembrane...; Region: PTS_IIB_mannitol; cd05567 481805002497 active site 481805002498 P-loop; other site 481805002499 phosphorylation site [posttranslational modification] 481805002500 L-sorbose-1-phosphate reductase; Region: sorbose_phosphate_red; cd08238 481805002501 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 481805002502 putative NAD(P) binding site [chemical binding]; other site 481805002503 catalytic Zn binding site [ion binding]; other site 481805002504 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 481805002505 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 481805002506 putative active site [active] 481805002507 Transcriptional regulator [Transcription]; Region: MtlR; COG3722 481805002508 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10022 481805002509 nucleoside triphosphate hydrolase domain-containing protein; Reviewed; Region: PRK09270 481805002510 Nucleoside/nucleotide kinase (NK) is a protein superfamily consisting of multiple families of enzymes that share structural similarity and are functionally related to the catalysis of the reversible phosphate group transfer from nucleoside triphosphates...; Region: NK; cl17190 481805002511 active site 481805002512 erythrose 4-phosphate dehydrogenase; Provisional; Region: PRK13535 481805002513 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 481805002514 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 481805002515 Phosphoglycerate kinase (PGK) is a monomeric enzyme which catalyzes the transfer of the high-energy phosphate group of 1,3-bisphosphoglycerate to ADP, forming ATP and 3-phosphoglycerate. This reaction represents the first of the two substrate-level...; Region: Phosphoglycerate_kinase; cd00318 481805002516 Phosphoglycerate kinase; Region: PGK; pfam00162 481805002517 substrate binding site [chemical binding]; other site 481805002518 hinge regions; other site 481805002519 ADP binding site [chemical binding]; other site 481805002520 catalytic site [active] 481805002521 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 481805002522 Class II Type A, Fructose-1,6-bisphosphate (FBP) aldolases. The enzyme catalyses the zinc-dependent, reversible aldol condensation of dihydroxyacetone phosphate with glyceraldehyde-3-phosphate to form fructose-1,6-bisphosphate. FBP aldolase is...; Region: FBP_aldolase_IIA; cd00946 481805002523 active site 481805002524 intersubunit interface [polypeptide binding]; other site 481805002525 zinc binding site [ion binding]; other site 481805002526 Na+ binding site [ion binding]; other site 481805002527 mechanosensitive channel MscS; Provisional; Region: PRK10334 481805002528 Mechanosensitive ion channel; Region: MS_channel; pfam00924 481805002529 arginine exporter protein; Provisional; Region: PRK09304 481805002530 Uncharacterized conserved protein [Function unknown]; Region: COG2968 481805002531 oxidative stress defense protein; Provisional; Region: PRK11087 481805002532 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805002533 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481805002534 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481805002535 Acetyl-CoA hydrolase/transferase N-terminal domain; Region: AcetylCoA_hydro; pfam02550 481805002536 succinate CoA transferase; Region: YgfH_subfam; TIGR03458 481805002537 Acetyl-CoA hydrolase/transferase C-terminal domain; Region: AcetylCoA_hyd_C; pfam13336 481805002538 methylmalonyl-CoA decarboxylase; Provisional; Region: PRK11423 481805002539 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 481805002540 substrate binding site [chemical binding]; other site 481805002541 oxyanion hole (OAH) forming residues; other site 481805002542 trimer interface [polypeptide binding]; other site 481805002543 membrane ATPase/protein kinase; Provisional; Region: PRK09435 481805002544 The function of this protein family is unkown. The protein sequences are similar to the ArgK protein in E. coli. ArgK protein is a membrane ATPase which is required for transporting arginine, ornithine and lysine into the cells by the arginine and...; Region: ArgK-like; cd03114 481805002545 Walker A; other site 481805002546 methylmalonyl-CoA mutase; Reviewed; Region: PRK09426 481805002547 Coenzyme B12-dependent-methylmalonyl coenzyme A (CoA) mutase (MCM) family, Alpha subunit-like subfamily; contains proteins similar to the alpha subunit of Propionbacterium shermanni MCM, as well as human and E. coli MCM. Members of this subfamily contain...; Region: MM_CoA_mutase_alpha_like; cd03679 481805002548 active site 481805002549 substrate binding site [chemical binding]; other site 481805002550 coenzyme B12 binding site [chemical binding]; other site 481805002551 methylmalonyl CoA mutase B12 binding domain. This domain binds to B12 (adenosylcobamide), which initiates the conversion of succinyl CoA and methylmalonyl CoA by forming an adenosyl radical, which then undergoes a rearrangement exchanging a hydrogen atom...; Region: MM_CoA_mut_B12_BD; cd02071 481805002552 B12 binding site [chemical binding]; other site 481805002553 cobalt ligand [ion binding]; other site 481805002554 chromosome replication initiation inhibitor protein; Validated; Region: PRK03635 481805002555 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805002556 The C-terminal substrate binding domain of LysR-type transcriptional regulator, ArgP (IciA), for arginine exporter (ArgO); contains the type 2 periplasmic binding fold; Region: PBP2_IciA_ArgP; cd08428 481805002557 putative dimerization interface [polypeptide binding]; other site 481805002558 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481805002559 RPI_A: Ribose 5-phosphate isomerase type A (RPI_A) subfamily; RPI catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate, the first step of the non-oxidative branch of the pentose phosphate pathway. This reaction leads to the...; Region: RPI_A; cd01398 481805002560 tetramer (dimer of dimers) interface [polypeptide binding]; other site 481805002561 active site 481805002562 dimer interface [polypeptide binding]; other site 481805002563 D-3-phosphoglycerate dehydrogenase; Provisional; Region: PRK11790 481805002564 Phosphoglycerate dehydrogenases, NAD-binding and catalytic domains; Region: PGDH_3; cd12176 481805002565 ligand binding site [chemical binding]; other site 481805002566 NAD binding site [chemical binding]; other site 481805002567 tetramer interface [polypeptide binding]; other site 481805002568 catalytic site [active] 481805002569 C-terminal ACT (regulatory) domain of D-3-Phosphoglycerate Dehydrogenase (3PGDH) found in fungi and bacteria; Region: ACT_3PGDH; cd04901 481805002570 L-serine binding site [chemical binding]; other site 481805002571 ACT domain interface; other site 481805002572 5-formyltetrahydrofolate cyclo-ligase family; Region: 5-FTHF_cyc-lig; pfam01812 481805002573 5-formyltetrahydrofolate cyclo-ligase family protein; Provisional; Region: PRK10333 481805002574 Z-ring-associated protein; Provisional; Region: PRK10972 481805002575 hypothetical protein; Reviewed; Region: PRK01736 481805002576 proline aminopeptidase P II; Provisional; Region: PRK10879 481805002577 Aminopeptidase P, N-terminal domain; Region: AMP_N; pfam05195 481805002578 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 481805002579 active site 481805002580 2-octaprenyl-6-methoxyphenyl hydroxylase; Validated; Region: PRK05732 481805002581 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 481805002582 oxidoreductase; Provisional; Region: PRK08013 481805002583 Ubiquinone biosynthesis hydroxylase, UbiH/UbiF/VisC/COQ6 family; Region: Ubi-OHases; TIGR01988 481805002584 glycine cleavage system aminomethyltransferase T; Reviewed; Region: gcvT; PRK00389 481805002585 Glycine cleavage T-protein C-terminal barrel domain; Region: GCV_T_C; pfam08669 481805002586 Glycine cleavage H-protein. Glycine cleavage H-proteins are part of the glycine cleavage system (GCS) found in bacteria, archea and the mitochondria of eukaryotes. GCS is a multienzyme complex consisting of 4 different components (P-, H-, T- and...; Region: GCS_H; cd06848 481805002587 lipoyl attachment site [posttranslational modification]; other site 481805002588 glycine dehydrogenase; Provisional; Region: PRK05367 481805002589 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 481805002590 tetramer interface [polypeptide binding]; other site 481805002591 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805002592 catalytic residue [active] 481805002593 Glycine cleavage system P-protein, alpha- and beta-subunits. This family consists of Glycine cleavage system P-proteins EC:1.4.4.2 from bacterial, mammalian and plant sources. The P protein is part of the glycine decarboxylase multienzyme complex EC:2.1; Region: GDC-P; cd00613 481805002594 tetramer interface [polypeptide binding]; other site 481805002595 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805002596 catalytic residue [active] 481805002597 putative NAD(P)-binding oxidoreductase; Provisional; Region: PRK09730 481805002598 classical (c) SDRs; Region: SDR_c; cd05233 481805002599 NAD(P) binding site [chemical binding]; other site 481805002600 active site 481805002601 6-phospho-beta-glucosidase BglA; Provisional; Region: PRK15014 481805002602 beta-galactosidase; Region: BGL; TIGR03356 481805002603 ASC-1 homology domain, subfamily similar to Escherichia coli Yqfb. The ASCH domain, a small beta-barrel domain found in all three kingdoms of life, resembles the RNA-binding PUA domain and may also interact with RNA. ASCH has been proposed to function as...; Region: ASCH_yqfb_like; cd06552 481805002604 hemolysin; Provisional; Region: PRK15087 481805002605 channel protein, hemolysin III family; Region: hlyIII; TIGR01065 481805002606 putative global regulator; Reviewed; Region: PRK09559 481805002607 folate-binding protein YgfZ; Region: ygfZ_signature; TIGR03317 481805002608 hypothetical protein; Provisional; Region: PRK10878 481805002609 Protein of unknown function (DUF1434); Region: DUF1434; pfam07254 481805002610 flavodoxin FldB; Provisional; Region: PRK12359 481805002611 site-specific tyrosine recombinase XerD; Reviewed; Region: xerD; PRK00283 481805002612 XerD and XerC integrases, DNA breaking-rejoining enzymes, N- and C-terminal domains. XerD-like integrases are involved in the site-specific integration and excision of lysogenic bacteriophage genomes, transposition of conjugative transposons, termination...; Region: INT_XerDC; cd00798 481805002613 active site 481805002614 Int/Topo IB signature motif; other site 481805002615 protein disulfide isomerase II DsbC; Provisional; Region: PRK10877 481805002616 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 481805002617 dimerization domain [polypeptide binding]; other site 481805002618 dimer interface [polypeptide binding]; other site 481805002619 catalytic residues [active] 481805002620 ssDNA exonuclease RecJ; Provisional; Region: PRK11070 481805002621 DHH family; Region: DHH; pfam01368 481805002622 DHHA1 domain; Region: DHHA1; pfam02272 481805002623 peptide chain release factor 2; Validated; Region: prfB; PRK00578 481805002624 This domain is found in peptide chain release factors; Region: PCRF; smart00937 481805002625 RF-1 domain; Region: RF-1; pfam00472 481805002626 lysyl-tRNA synthetase; Reviewed; Region: lysS; PRK00484 481805002627 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 481805002628 dimer interface [polypeptide binding]; other site 481805002629 putative anticodon binding site; other site 481805002630 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 481805002631 motif 1; other site 481805002632 active site 481805002633 motif 2; other site 481805002634 motif 3; other site 481805002635 Isopentenyldiphosphate isomerase [Lipid metabolism]; Region: Idi; COG1443 481805002636 Isopentenyl diphosphate (IPP) isomerase, a member of the Nudix hydrolase superfamily, is a key enzyme in the isoprenoid biosynthetic pathway. Isoprenoids comprise a large family of natural products including sterols, carotenoids, dolichols and prenylated...; Region: IPP_Isomerase; cd02885 481805002637 active site 481805002638 metal binding site [ion binding]; metal-binding site 481805002639 nudix motif; other site 481805002640 xanthine permease; Region: pbuX; TIGR03173 481805002641 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12809 481805002642 4Fe-4S binding domain; Region: Fer4; pfam00037 481805002643 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 481805002644 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805002645 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 481805002646 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 481805002647 guanine deaminase; Provisional; Region: PRK09228 481805002648 Guanine deaminase (GDEase). Guanine deaminase is an aminohydrolase responsible for the conversion of guanine to xanthine and ammonia, the first step to utilize guanine as a nitrogen source. This reaction also removes the guanine base from the pool and...; Region: GDEase; cd01303 481805002649 active site 481805002650 uracil-xanthine permease; Region: ncs2; TIGR00801 481805002651 putative hypoxanthine oxidase; Provisional; Region: PRK09800 481805002652 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 481805002653 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; cl03161 481805002654 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 481805002655 probable selenate reductase, FAD-binding subunit; Region: Se_sel_red_FAD; TIGR03312 481805002656 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 481805002657 putative selenium metabolism protein SsnA; Region: Se_ssnA; TIGR03314 481805002658 TRZ/ATZ family contains enzymes from the atrazine degradation pathway and related hydrolases. Atrazine, a chlorinated herbizide, can be catabolized by a variety of different bacteria. The first three steps of the atrazine dehalogenation pathway are...; Region: ATZ_TRZ_like; cd01298 481805002659 active site 481805002660 putative substrate binding pocket [chemical binding]; other site 481805002661 putative selenate reductase subunit YgfK; Provisional; Region: PRK09853 481805002662 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 481805002663 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 481805002664 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805002665 GT_2_like_f is a subfamily of the glycosyltransferase family 2 (GT-2) with unknown function; Region: GT_2_like_f; cd04182 481805002666 metal-binding site 481805002667 probable selenium-dependent hydroxylase accessory protein YqeC; Region: TIGR03172 481805002668 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 481805002669 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 481805002670 XdhC Rossmann domain; Region: XdhC_C; pfam13478 481805002671 selenium-dependent molybdenum hydroxylase system protein, YqeB family; Region: matur_yqeB; TIGR03309 481805002672 M14 family of metallocarboxypeptidases and related proteins; Region: Peptidase_M14_like; cl11393 481805002673 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 481805002674 carbamate kinase; Reviewed; Region: PRK12686 481805002675 putative substrate binding site [chemical binding]; other site 481805002676 homodimer interface [polypeptide binding]; other site 481805002677 nucleotide binding site [chemical binding]; other site 481805002678 nucleotide binding site [chemical binding]; other site 481805002679 D-hydantoinase; Region: D-hydantoinase; TIGR02033 481805002680 D-hydantoinases (D-HYD) also called dihydropyrimidases (DHPase) and related proteins; DHPases are a family of enzymes that catalyze the reversible hydrolytic ring opening of the amide bond in five- or six-membered cyclic diamides, like dihydropyrimidine...; Region: D-HYD; cd01314 481805002681 tetramer interface [polypeptide binding]; other site 481805002682 active site 481805002683 peptidase; Reviewed; Region: PRK13004 481805002684 M20 Peptidases with similarity to acetylornithine deacetylases and succinyl-diaminopimelate desuccinylases; Region: M20_ArgE_DapE_like4; cd05649 481805002685 putative metal binding site [ion binding]; other site 481805002686 putative dimer interface [polypeptide binding]; other site 481805002687 Threonine dehydratase [Amino acid transport and metabolism]; Region: IlvA; COG1171 481805002688 Tryptophan synthase beta superfamily (fold type II); this family of pyridoxal phosphate (PLP)-dependent enzymes catalyzes beta-replacement and beta-elimination reactions. This CD corresponds to aminocyclopropane-1-carboxylate deaminase (ACCD), tryptophan...; Region: Trp-synth-beta_II; cd00640 481805002689 catalytic residue [active] 481805002690 aspartate/ornithine carbamoyltransferase family protein; Validated; Region: PRK07200 481805002691 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 481805002692 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 481805002693 GAF domain; Region: GAF; cl17456 481805002694 Transcriptional regulator containing PAS, AAA-type ATPase, and DNA-binding domains [Transcription / Signal transduction mechanisms]; Region: RocR; COG3829 481805002695 PAS domain; Region: PAS; smart00091 481805002696 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805002697 Walker A motif; other site 481805002698 ATP binding site [chemical binding]; other site 481805002699 Walker B motif; other site 481805002700 arginine finger; other site 481805002701 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 481805002702 xanthine dehydrogenase subunit XdhC; Provisional; Region: PRK09908 481805002703 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 481805002704 catalytic loop [active] 481805002705 iron binding site [ion binding]; other site 481805002706 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 481805002707 xanthine dehydrogenase subunit XdhB; Provisional; Region: PRK09971 481805002708 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; pfam03450 481805002709 xanthine dehydrogenase subunit XdhA; Provisional; Region: PRK09970 481805002710 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 481805002711 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 481805002712 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481805002713 Peptidase family M23; Region: Peptidase_M23; pfam01551 481805002714 Glycosyl hydrolases family 15; Region: Glyco_hydro_15; pfam00723 481805002715 type III secretion system protein SpaO; Validated; Region: PRK08158 481805002716 Flagellar motor switch/type III secretory pathway protein [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliN; COG1886 481805002717 type III secretion system protein SpaP; Provisional; Region: spaP; PRK12796 481805002718 type III secretion system protein SpaQ; Provisional; Region: PRK15333 481805002719 type III secretion protein SpaR/YscT/HrcT; Region: fliR_like_III; TIGR01401 481805002720 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805002721 DNA binding residues [nucleotide binding] 481805002722 dimerization interface [polypeptide binding]; other site 481805002723 type III secretion system needle complex protein PrgH; Provisional; Region: PRK15327; cl12363 481805002724 Type III secretion system protein PrgH-EprH (PrgH); Region: PrgH; pfam09480 481805002725 Type III secretion needle MxiH like; Region: MxiH; cl09641 481805002726 type III secretion system needle complex protein PrgJ; Provisional; Region: PRK15325 481805002727 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805002728 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805002729 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805002730 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805002731 invasion protein OrgB; Provisional; Region: PRK15322 481805002732 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481805002733 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805002734 DNA binding residues [nucleotide binding] 481805002735 dimerization interface [polypeptide binding]; other site 481805002736 Soluble lytic murein transglycosylase and related regulatory proteins (some contain LysM/invasin domains) [Cell envelope biogenesis, outer membrane]; Region: MltE; COG0741 481805002737 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 481805002738 N-acetyl-D-glucosamine binding site [chemical binding]; other site 481805002739 catalytic residue [active] 481805002740 transcriptional regulator; Provisional; Region: PRK11906 481805002741 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 481805002742 DNA binding site [nucleotide binding] 481805002743 Tetratricopeptide repeat; Region: TPR_2; pfam07719 481805002744 type III secretion low calcium response chaperone LcrH/SycD; Region: LcrH_SycD; TIGR02552 481805002745 Tetratricopeptide repeat; Region: TPR_3; pfam07720 481805002746 Tetratricopeptide repeat; Region: TPR_3; pfam07720 481805002747 hyperosmolarity resistance protein Ebh, N-terminal domain; Region: hyperosmo_Ebh; TIGR04264 481805002748 Uncharacterized protein conserved in Bacteroidetes; Region: Bacuni_01323_like; cd12871 481805002749 DNA-binding winged-HTH domains [Transcription]; Region: CadC; COG3710 481805002750 DNA-binding HTH domain-containing proteins [Transcription]; Region: CsgD; COG2771 481805002751 DNA binding residues [nucleotide binding] 481805002752 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 481805002753 serine transporter; Region: stp; TIGR00814 481805002754 putative acyltransferase; Provisional; Region: PRK05790 481805002755 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 481805002756 dimer interface [polypeptide binding]; other site 481805002757 active site 481805002758 5-keto-4-deoxyuronate isomerase; Provisional; Region: PRK00924 481805002759 2-deoxy-D-gluconate 3-dehydrogenase; Validated; Region: PRK08993 481805002760 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 481805002761 NADP binding site [chemical binding]; other site 481805002762 homodimer interface [polypeptide binding]; other site 481805002763 active site 481805002764 MFS transporter, sugar porter (SP) family; Region: SP; TIGR00879 481805002765 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805002766 putative substrate translocation pore; other site 481805002767 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805002768 putative racemase; Provisional; Region: PRK10200 481805002769 aspartate racemase; Region: asp_race; TIGR00035 481805002770 DNA-binding transcriptional regulator LysR; Provisional; Region: PRK11013 481805002771 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805002772 The C-terminal substrate binding domain of LysR, transcriptional regulator for lysine biosynthesis, contains the type 2 periplasmic binding fold; Region: PBP2_LysR; cd08456 481805002773 putative dimerization interface [polypeptide binding]; other site 481805002774 diaminopimelate decarboxylase; Provisional; Region: PRK11165 481805002775 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Diaminopimelate Decarboxylase; Region: PLPDE_III_DapDC; cd06828 481805002776 active site 481805002777 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 481805002778 substrate binding site [chemical binding]; other site 481805002779 catalytic residues [active] 481805002780 dimer interface [polypeptide binding]; other site 481805002781 DNA-binding transcriptional regulator GalR; Provisional; Region: PRK10727 481805002782 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481805002783 DNA binding site [nucleotide binding] 481805002784 domain linker motif; other site 481805002785 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 481805002786 dimerization interface (closed form) [polypeptide binding]; other site 481805002787 ligand binding site [chemical binding]; other site 481805002788 bifunctional acyl-[acyl carrier protein] synthetase/2-acylglycerophosphoethanolamine acyltransferase; Validated; Region: PRK08043 481805002789 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: AGPAT-like; Region: LPLAT_AGPAT-like; cd07989 481805002790 putative acyl-acceptor binding pocket; other site 481805002791 C-terminal domain of the acyl-acyl carrier protein synthetase (also called 2-acylglycerophosphoethanolamine acyltransferase, Aas); Region: AAS_C; cd05909 481805002792 acyl-activating enzyme (AAE) consensus motif; other site 481805002793 putative AMP binding site [chemical binding]; other site 481805002794 lysophospholipid transporter LplT; Provisional; Region: PRK11195 481805002795 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805002796 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481805002797 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481805002798 active site 481805002799 catalytic tetrad [active] 481805002800 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 481805002801 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 481805002802 MutH is a 28kD endonuclease involved in methyl-directed DNA mismatch repair in gram negative bacteria. MutH is both sequence-specific and methylation-specific, introducing a nick in the unmethylated strand of a hemi-methylated d(GATC) DNA duplex. MutH...; Region: MutH_Sau3AI; cd00583 481805002803 putative DNA-binding cleft [nucleotide binding]; other site 481805002804 putative DNA clevage site; other site 481805002805 molecular lever; other site 481805002806 Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant...; Region: Ap4A_hydrolase_plant_like; cd03671 481805002807 putative active site [active] 481805002808 Ap4A binding site [chemical binding]; other site 481805002809 nudix motif; other site 481805002810 putative metal binding site [ion binding]; other site 481805002811 fused phosphoenolpyruvate-protein phosphotransferase PtsP/GAF domain; Provisional; Region: PRK11061 481805002812 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 481805002813 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 481805002814 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 481805002815 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 481805002816 prolipoprotein diacylglyceryl transferase; Region: lgt; TIGR00544 481805002817 thymidylate synthase; Reviewed; Region: thyA; PRK01827 481805002818 Thymidylate synthase and pyrimidine hydroxymethylase: Thymidylate synthase (TS) and deoxycytidylate hydroxymethylase (dCMP-HMase) are homologs that catalyze analogous alkylation of C5 of pyrimidine nucleotides. Both enzymes are involved in the...; Region: TS_Pyrimidine_HMase; cd00351 481805002819 dimerization interface [polypeptide binding]; other site 481805002820 active site 481805002821 hypothetical protein; Provisional; Region: PRK10506 481805002822 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 481805002823 hypothetical protein; Provisional; Region: PRK10557 481805002824 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 481805002825 hypothetical protein; Provisional; Region: PRK11521 481805002826 hypothetical protein; Provisional; Region: PRK10332 481805002827 Prepilin peptidase dependent protein C term (DUF3728); Region: DUF3728; pfam12528 481805002828 exonuclease V subunit gamma; Provisional; Region: recC; PRK11069 481805002829 exodeoxyribonuclease V, gamma subunit; Region: recC; TIGR01450 481805002830 protease3; Provisional; Region: PRK15101 481805002831 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 481805002832 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 481805002833 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 481805002834 exonuclease V subunit beta; Provisional; Region: recB; PRK10876 481805002835 CRISPR/Cas system-associated protein Cas4; Region: Cas4_I-A_I-B_I-C_I-D_II-B; cl00641 481805002836 exonuclease V subunit alpha; Provisional; Region: recD; PRK10875 481805002837 AAA domain; Region: AAA_30; pfam13604 481805002838 Family description; Region: UvrD_C_2; pfam13538 481805002839 N-acetylglutamate synthase; Validated; Region: PRK05279 481805002840 AAK_NAGS-ABP: N-acetylglutamate (NAG) kinase-like domain of the NAG Synthase (NAGS) of the arginine-biosynthesis pathway (ABP) found in gamma- and beta-proteobacteria and higher plant chloroplasts. Domain architecture of these NAGS consisted of an...; Region: AAK_NAGS-ABP; cd04237 481805002841 putative feedback inhibition sensing region; other site 481805002842 putative nucleotide binding site [chemical binding]; other site 481805002843 putative substrate binding site [chemical binding]; other site 481805002844 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481805002845 Coenzyme A binding pocket [chemical binding]; other site 481805002846 AMIN domain; Region: AMIN; pfam11741 481805002847 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 481805002848 active site 481805002849 metal binding site [ion binding]; metal-binding site 481805002850 murein transglycosylase A; Provisional; Region: mltA; PRK11162 481805002851 MltA specific insert domain; Region: MltA; pfam03562 481805002852 3D domain; Region: 3D; pfam06725 481805002853 sulfur acceptor protein CsdL; Provisional; Region: PRK15116 481805002854 Family of activating enzymes (E1) of ubiquitin-like proteins related to the E.coli hypothetical protein ygdL. The common reaction mechanism catalyzed by E1-like enzymes begins with a nucleophilic attack of the C-terminal carboxylate of the ubiquitin-like...; Region: YgdL_like; cd00755 481805002855 putative ATP binding site [chemical binding]; other site 481805002856 putative substrate interface [chemical binding]; other site 481805002857 CsdA-binding activator; Provisional; Region: PRK15019 481805002858 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 481805002859 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 481805002860 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 481805002861 catalytic residue [active] 481805002862 Bacterial protein of unknown function (DUF903); Region: DUF903; pfam06004 481805002863 DNA-binding transcriptional activator GcvA; Provisional; Region: PRK11139 481805002864 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805002865 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 481805002866 dimerization interface [polypeptide binding]; other site 481805002867 substrate binding pocket [chemical binding]; other site 481805002868 hypothetical protein; Provisional; Region: PRK10873 481805002869 putative 23S rRNA C2498 ribose 2'-O-ribose methyltransferase; Provisional; Region: PRK11760 481805002870 FtsJ-like methyltransferase; Region: FtsJ; pfam01728 481805002871 DNA-binding transcriptional activator FucR; Provisional; Region: PRK10411 481805002872 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 481805002873 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481805002874 L-fucose mutarotase; Provisional; Region: fucU; PRK15420 481805002875 L-fuculokinase; Provisional; Region: PRK10331 481805002876 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 481805002877 nucleotide binding site [chemical binding]; other site 481805002878 L-fucose isomerase; Provisional; Region: fucI; PRK10991 481805002879 L-fucose isomerase (FucIase); FucIase converts L-fucose, an aldohexose, to its ketose form, which prepares it for aldol cleavage (similar to the isomerization of glucose during glycolysis). L-fucose (or 6-deoxy-L-galactose) is found in blood group...; Region: L-fucose_isomerase; cd03556 481805002880 hexamer (dimer of trimers) interface [polypeptide binding]; other site 481805002881 trimer interface [polypeptide binding]; other site 481805002882 substrate binding site [chemical binding]; other site 481805002883 Mn binding site [ion binding]; other site 481805002884 Fucose permease [Carbohydrate transport and metabolism]; Region: FucP; COG0738 481805002885 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805002886 putative substrate translocation pore; other site 481805002887 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 481805002888 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 481805002889 intersubunit interface [polypeptide binding]; other site 481805002890 active site 481805002891 Zn2+ binding site [ion binding]; other site 481805002892 L-1,2-propanediol oxidoreductase; Provisional; Region: PRK10624 481805002893 Lactadehyde:propanediol oxidoreductase (LPO) catalyzes the interconversion between L-lactaldehyde and L-1,2-propanediol in Escherichia coli and other enterobacteria; Region: LPO; cd08176 481805002894 dimer interface [polypeptide binding]; other site 481805002895 active site 481805002896 metal binding site [ion binding]; metal-binding site 481805002897 flap endonuclease-like protein; Provisional; Region: PRK09482 481805002898 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 481805002899 active site 481805002900 metal binding site 1 [ion binding]; metal-binding site 481805002901 putative 5' ssDNA interaction site; other site 481805002902 metal binding site 3; metal-binding site 481805002903 metal binding site 2 [ion binding]; metal-binding site 481805002904 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 481805002905 putative DNA binding site [nucleotide binding]; other site 481805002906 putative metal binding site [ion binding]; other site 481805002907 L-serine dehydratase, iron-sulfur-dependent, single chain form; Region: sda_mono; TIGR00720 481805002908 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 481805002909 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 481805002910 Amino acid permeases [Amino acid transport and metabolism]; Region: SdaC; COG0814 481805002911 serine transporter; Region: stp; TIGR00814 481805002912 Predicted Rossmann fold nucleotide-binding protein [General function prediction only]; Region: COG1611 481805002913 Domain of unknown function (DUF3412); Region: DUF3412; pfam11892 481805002914 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2904 481805002915 7-cyano-7-deazaguanine reductase; Provisional; Region: queF; PRK11792 481805002916 Enzyme related to GTP cyclohydrolase I [General function prediction only]; Region: COG0780 481805002917 SecY interacting protein Syd; Provisional; Region: PRK04968 481805002918 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3098 481805002919 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 481805002920 tRNA pseudouridine isomerase C; Region: PseudoU_synth_TruC; cd02563 481805002921 probable active site [active] 481805002922 flavodoxin; Provisional; Region: PRK08105 481805002923 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805002924 D-galactonate transporter; Region: 2A0114; TIGR00893 481805002925 putative substrate translocation pore; other site 481805002926 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 481805002927 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 481805002928 active site 481805002929 tetramer interface [polypeptide binding]; other site 481805002930 glucarate dehydratase; Region: glucar-dehydr; TIGR03247 481805002931 D-Glucarate dehydratase (GlucD) catalyzes the dehydration of both D-glucarate and L-idarate to form 5-keto-4-deoxy-D-glucarate (5-KDG) , the initial reaction of the catabolic pathway for (D)-glucarate. GlucD belongs to the enolase superfamily of enzymes; Region: D-glucarate_dehydratase; cd03323 481805002932 active site 481805002933 tetramer interface [polypeptide binding]; other site 481805002934 hybrid sensory histidine kinase BarA; Provisional; Region: PRK11107 481805002935 Uncharacterized signal transduction histidine kinase domain (DUF2222); Region: DUF2222; pfam09984 481805002936 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805002937 dimerization interface [polypeptide binding]; other site 481805002938 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805002939 dimer interface [polypeptide binding]; other site 481805002940 phosphorylation site [posttranslational modification] 481805002941 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805002942 ATP binding site [chemical binding]; other site 481805002943 Mg2+ binding site [ion binding]; other site 481805002944 G-X-G motif; other site 481805002945 Uncharacterized domain of BarA-like signal transduction histidine kinases [Signal transduction mechanisms]; Region: COG4999 481805002946 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805002947 active site 481805002948 phosphorylation site [posttranslational modification] 481805002949 intermolecular recognition site; other site 481805002950 dimerization interface [polypeptide binding]; other site 481805002951 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 481805002952 putative binding surface; other site 481805002953 active site 481805002954 23S rRNA m(5)U1939 methyltransferase; Reviewed; Region: rumA; PRK13168 481805002955 TRAM domain; Region: TRAM; pfam01938 481805002956 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805002957 S-adenosylmethionine binding site [chemical binding]; other site 481805002958 (p)ppGpp synthetase I/GTP pyrophosphokinase; Provisional; Region: relA; PRK10872 481805002959 HD domain; Region: HD_4; pfam13328 481805002960 Nucleotidyltransferase (NT) domain of RelA- and SpoT-like ppGpp synthetases and hydrolases; Region: NT_Rel-Spo_like; cd05399 481805002961 synthetase active site [active] 481805002962 NTP binding site [chemical binding]; other site 481805002963 metal binding site [ion binding]; metal-binding site 481805002964 TGS_RelA_SpoT: The RelA (SpoT) protein, also referred to as ppGpp hydrolase/synthetase, is a ribosome-associated protein that is activated during amino acid starvation and thought to mediate the stringent response. RelA contains a TGS domain, named after...; Region: TGS_RelA_SpoT; cd01668 481805002965 ACT domain found C-terminal of the RelA/SpoT domains; Region: ACT_RelA-SpoT; cd04876 481805002966 antitoxin MazE; Provisional; Region: PRK09798 481805002967 toxin MazF; Provisional; Region: PRK09907 481805002968 nucleoside triphosphate pyrophosphohydrolase; Reviewed; Region: mazG; PRK09562 481805002969 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) N-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs; Region: NTP-PPase_MazG_Nterm; cd11528 481805002970 homodimer interface [polypeptide binding]; other site 481805002971 metal binding site [ion binding]; metal-binding site 481805002972 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) C-terminal tandem-domain of MazG proteins from Escherichia coli and bacterial homologs' Region: NTP-PPase_MazG_Cterm; cd11529 481805002973 homodimer interface [polypeptide binding]; other site 481805002974 active site 481805002975 putative chemical substrate binding site [chemical binding]; other site 481805002976 metal binding site [ion binding]; metal-binding site 481805002977 CTP synthetase; Validated; Region: pyrG; PRK05380 481805002978 CTP synthetase (CTPs) is a two-domain protein, which consists of an N-terminal synthetase domain and C-terminal glutaminase domain. The enzymes hydrolyze the amide bond of glutamine to ammonia and glutamate at the glutaminase domains and transfer nascent...; Region: CTGs; cd03113 481805002979 Catalytic site [active] 481805002980 active site 481805002981 UTP binding site [chemical binding]; other site 481805002982 Type 1 glutamine amidotransferase (GATase1) domain found in Cytidine Triphosphate Synthetase; Region: GATase1_CTP_Synthase; cd01746 481805002983 active site 481805002984 putative oxyanion hole; other site 481805002985 catalytic triad [active] 481805002986 enolase; Provisional; Region: eno; PRK00077 481805002987 Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoenolpyruvate as part of the glycolytic and gluconeogenesis pathways. The reaction is facilitated by the presence of metal ions; Region: enolase; cd03313 481805002988 dimer interface [polypeptide binding]; other site 481805002989 metal binding site [ion binding]; metal-binding site 481805002990 substrate binding pocket [chemical binding]; other site 481805002991 Beta-propeller domains of methanol dehydrogenase type [General function prediction only]; Region: COG1512 481805002992 Repair protein; Region: Repair_PSII; pfam04536 481805002993 Organic radical activating enzymes [Posttranslational modification, protein turnover, chaperones]; Region: NrdG; COG0602 481805002994 putative 7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE; Region: rSAM_QueE_Ecoli; TIGR04322 481805002995 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 481805002996 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 481805002997 Sugar (pentulose and hexulose) kinases [Carbohydrate transport and metabolism]; Region: XylB; COG1070 481805002998 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cl17037 481805002999 nucleotide binding site [chemical binding]; other site 481805003000 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481805003001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805003002 2-deoxy-D-gluconate 3-dehydrogenase; Provisional; Region: PRK06935 481805003003 gluconate 5-dehydrogenase (Ga5DH)-like, classical (c) SDRs; Region: Ga5DH-like_SDR_c; cd05347 481805003004 NADP binding site [chemical binding]; other site 481805003005 homodimer interface [polypeptide binding]; other site 481805003006 active site 481805003007 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 481805003008 FAD binding domain; Region: FAD_binding_4; pfam01565 481805003009 benzoate transport; Region: 2A0115; TIGR00895 481805003010 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805003011 putative substrate translocation pore; other site 481805003012 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 481805003013 Ligand binding site [chemical binding]; other site 481805003014 Electron transfer flavoprotein domain; Region: ETF; pfam01012 481805003015 Protein of unknown function (DUF2950); Region: DUF2950; pfam11453 481805003016 Electron transfer flavoprotein, alpha subunit [Energy production and conversion]; Region: FixB; COG2025 481805003017 Adenine nucleotide alpha hydrolases superfamily including N type ATP PPases, ATP sulphurylases Universal Stress Response protein and electron transfer flavoprotein (ETF). The domain forms a apha/beta/apha fold which binds to Adenosine nucleotide; Region: AANH_like; cl00292 481805003018 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 481805003019 Glycerol-3-phosphate responsive antiterminator (mRNA-binding) [Transcription]; Region: GlpP; COG1954 481805003020 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 481805003021 putative oxidoreductase FixC; Provisional; Region: PRK10157 481805003022 6-pyruvoyl tetrahydropterin synthase (PTPS). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids, as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after uptake by a...; Region: PTPS; cd00470 481805003023 homohexamer interface [polypeptide binding]; other site 481805003024 putative substrate stabilizing pore; other site 481805003025 pterin binding site; other site 481805003026 sulfite reductase subunit alpha; Provisional; Region: cysJ; PRK10953 481805003027 Flavodoxin; Region: Flavodoxin_1; pfam00258 481805003028 Cytochrome p450- like alpha subunits of E. coli sulfite reductase (SiR) multimerize with beta subunits to catalyze the NADPH dependent reduction of sulfite to sulfide. Beta subunits have an Fe4S4 cluster and a siroheme, while the alpha subunits (cysJ...; Region: SiR; cd06199 481805003029 FAD binding pocket [chemical binding]; other site 481805003030 FAD binding motif [chemical binding]; other site 481805003031 catalytic residues [active] 481805003032 NAD binding pocket [chemical binding]; other site 481805003033 phosphate binding motif [ion binding]; other site 481805003034 beta-alpha-beta structure motif; other site 481805003035 sulfite reductase subunit beta; Provisional; Region: PRK13504 481805003036 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 481805003037 Nitrite/Sulfite reductase ferredoxin-like half domain; Region: NIR_SIR_ferr; pfam03460 481805003038 3'-phosphoadenosine 5'-phosphosulfate sulfotransferase (PAPS reductase)/FAD synthetase and related enzymes [Amino acid transport and metabolism / Coenzyme metabolism]; Region: CysH; COG0175 481805003039 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 481805003040 Active Sites [active] 481805003041 helicase Cas3; Provisional; Region: PRK09694 481805003042 CRISPR/Cas system-associated protein Cas3'' Region: Cas3''_I; cd09641 481805003043 CRISPR/Cas system-associated protein Cas3; Region: Cas3_I; cd09639 481805003044 CRISPR/Cas system-associated protein Cse1; Region: Cse1_I-E; cd09669 481805003045 CRISPR/Cas system-associated protein Cse2; Region: Cse2_I-E; cd09670 481805003046 CRISPR/Cas system-associated RAMP superfamily protein Cas7; Region: Cas7_I-E; cd09646 481805003047 CRISPR-associated protein (Cas_Cas5); Region: Cas_Cas5d; pfam09704 481805003048 CRISPR/Cas system-associated RAMP superfamily protein Cas5; Region: Cas5_I-E; cd09645 481805003049 CRISPR/Cas system-associated RAMP superfamily protein Cas6e; Region: Cas6_I-E; cd09664 481805003050 CRISPR/Cas system-associated protein Cas1; Region: Cas1_I-E; cd09719 481805003051 CRISPR/Cas system-associated protein Cas2; Region: Cas2_I-E; cd09648 481805003052 alkaline phosphatase isozyme conversion aminopeptidase; Provisional; Region: PRK10199 481805003053 M28 Zn-peptidases include aminopeptidases and carboxypeptidases; Region: M28; cd02690 481805003054 metal binding site [ion binding]; metal-binding site 481805003055 sulfate adenylyltransferase, small subunit; Region: CysD; TIGR02039 481805003056 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 481805003057 Active Sites [active] 481805003058 sulfate adenylyltransferase subunit 1; Provisional; Region: cysN; PRK05124 481805003059 CysN, together with protein CysD, forms the ATP sulfurylase (ATPS) complex; Region: CysN_ATPS; cd04166 481805003060 CysD dimerization site [polypeptide binding]; other site 481805003061 G1 box; other site 481805003062 putative GEF interaction site [polypeptide binding]; other site 481805003063 GTP/Mg2+ binding site [chemical binding]; other site 481805003064 Switch I region; other site 481805003065 G2 box; other site 481805003066 G3 box; other site 481805003067 Switch II region; other site 481805003068 G4 box; other site 481805003069 G5 box; other site 481805003070 CysN_NodQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NodQ_II; cd03695 481805003071 TCysN_NoDQ_II: This subfamily represents the domain II of the large subunit of ATP sulfurylase (ATPS): CysN or the N-terminal portion of NodQ, found mainly in proteobacteria and homologous to the domain II of EF-Tu. Escherichia coli ATPS consists of CysN...; Region: CysN_NoDQ_III; cd04095 481805003072 Adenosine 5'-phosphosulfate kinase (APSK) catalyzes the phosphorylation of adenosine 5'-phosphosulfate to form 3'-phosphoadenosine 5'-phosphosulfate (PAPS). The end-product PAPS is a biologically "activated" sulfate form...; Region: APSK; cd02027 481805003073 ligand-binding site [chemical binding]; other site 481805003074 Protein of unknown function (DUF3561); Region: DUF3561; pfam12084 481805003075 cell division protein FtsB; Reviewed; Region: ftsB; PRK00888 481805003076 Septum formation initiator [Cell division and chromosome partitioning]; Region: COG2919 481805003077 CDP-ME synthetase is involved in mevalonate-independent isoprenoid production; Region: CDP-ME_synthetase; cd02516 481805003078 substrate binding site; other site 481805003079 dimer interface; other site 481805003080 MECDP_synthase (2-C-methyl-D-erythritol-2,4-cyclodiphosphate synthase), encoded by the ispF gene, catalyzes the formation of 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (MEC) in the non-mevalonate deoxyxylulose (DOXP) pathway for isoprenoid biosynthesis; Region: MECDP_synthase; cd00554 481805003081 homotrimer interaction site [polypeptide binding]; other site 481805003082 zinc binding site [ion binding]; other site 481805003083 CDP-binding sites; other site 481805003084 tRNA pseudouridine synthase D; Reviewed; Region: truD; PRK00984 481805003085 Pseudouridine synthase, similar to Escherichia coli TruD; Region: PseudoU_synth_EcTruD; cd02575 481805003086 Permutation of conserved domain; other site 481805003087 active site 481805003088 5'(3')-nucleotidase/polyphosphatase; Provisional; Region: surE; PRK00346 481805003089 protein-L-isoaspartate O-methyltransferase; Reviewed; Region: pcm; PRK00312 481805003090 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805003091 S-adenosylmethionine binding site [chemical binding]; other site 481805003092 Membrane proteins related to metalloendopeptidases [Cell envelope biogenesis, outer membrane]; Region: NlpD; COG0739 481805003093 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481805003094 Peptidase family M23; Region: Peptidase_M23; pfam01551 481805003095 RNA polymerase sigma factor RpoS; Validated; Region: PRK05657 481805003096 Sigma-70 factor, region 1.2; Region: Sigma70_r1_2; pfam00140 481805003097 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481805003098 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 481805003099 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481805003100 DNA binding residues [nucleotide binding] 481805003101 putative transporter; Provisional; Region: PRK09821 481805003102 GntP family permease; Region: GntP_permease; pfam02447 481805003103 hypothetical protein; Provisional; Region: PRK09989 481805003104 putative aldolase; Validated; Region: PRK08130 481805003105 active site 481805003106 intersubunit interface [polypeptide binding]; other site 481805003107 Zn2+ binding site [ion binding]; other site 481805003108 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3395 481805003109 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases [Lipid metabolism]; Region: MmsB; COG2084 481805003110 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 481805003111 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 481805003112 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 481805003113 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481805003114 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805003115 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805003116 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805003117 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805003118 DNA mismatch repair protein MutS; Provisional; Region: PRK05399 481805003119 MutS domain I; Region: MutS_I; pfam01624 481805003120 MutS domain II; Region: MutS_II; pfam05188 481805003121 MutS domain III; Region: MutS_III; pfam05192 481805003122 ATP-binding cassette domain of MutS1 homolog; Region: ABC_MutS1; cd03284 481805003123 Walker A/P-loop; other site 481805003124 ATP binding site [chemical binding]; other site 481805003125 Q-loop/lid; other site 481805003126 ABC transporter signature motif; other site 481805003127 Walker B; other site 481805003128 D-loop; other site 481805003129 H-loop/switch region; other site 481805003130 Nitrous oxide-stimulated promoter; Region: YgbA_NO; pfam11756 481805003131 formate hydrogenlyase transcriptional activator FhlA; Provisional; Region: PRK15429 481805003132 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 481805003133 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 481805003134 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805003135 Walker A motif; other site 481805003136 ATP binding site [chemical binding]; other site 481805003137 Walker B motif; other site 481805003138 arginine finger; other site 481805003139 Bacterial regulatory protein, Fis family; Region: HTH_8; cl17420 481805003140 HypE (Hydrogenase expression/formation protein). HypE is involved in Ni-Fe hydrogenase biosynthesis. HypE dehydrates its own carbamoyl moiety in an ATP-dependent process to yield the enzyme thiocyanate. The N-terminal domain of HypE is related to the...; Region: HypE; cd02197 481805003141 dimerization interface [polypeptide binding]; other site 481805003142 hydrogenase expression/formation protein HypE; Region: hypE; TIGR02124 481805003143 ATP binding site [chemical binding]; other site 481805003144 hydrogenase isoenzymes formation protein HypD; Provisional; Region: PRK15062 481805003145 hydrogenase expression/formation protein HypD; Region: hypD; TIGR00075 481805003146 hydrogenase assembly chaperone; Provisional; Region: PRK10409 481805003147 hydrogenase nickel incorporation protein HypB; Provisional; Region: PRK10463 481805003148 Hydrogenase expression/synthesis hypA family; Region: HypA; cl17671 481805003149 hydrogenase nickel incorporation protein; Validated; Region: hypA; PRK03681 481805003150 formate hydrogenlyase regulatory protein HycA; Provisional; Region: PRK10198 481805003151 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 481805003152 formate hydrogenlyase subunit 3; Reviewed; Region: PRK08042 481805003153 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 481805003154 Formate hydrogenlyase subunit 4 [Energy production and conversion]; Region: HyfC; COG0650 481805003155 NADH dehydrogenase; Region: NADHdh; cl00469 481805003156 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 481805003157 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 481805003158 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 481805003159 formate hydrogenlyase complex iron-sulfur subunit; Provisional; Region: PRK12387 481805003160 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 481805003161 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 481805003162 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 481805003163 Endopeptidases belonging to membrane-bound hydrogen evolving hydrogenase group. In hydrogenase 3 from E coli, the maturation of the large subunit (HycE) requires the cleavage of a C-terminal peptide by the endopeptidase HycI, before the final formation...; Region: H2MP_MemB-H2evol; cd06067 481805003164 nickel binding site [ion binding]; other site 481805003165 cryptic 6-phospho-beta-glucosidase; Provisional; Region: PRK09852 481805003166 beta-galactosidase; Region: BGL; TIGR03356 481805003167 PTS system cellobiose/arbutin/salicin-specific transporter subunits IIBC; Provisional; Region: PRK09796 481805003168 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 481805003169 active site turn [active] 481805003170 phosphorylation site [posttranslational modification] 481805003171 PTS system, maltose and glucose-specific subfamily, IIC component; Region: pts-Glc; TIGR00852 481805003172 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481805003173 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481805003174 DNA binding site [nucleotide binding] 481805003175 domain linker motif; other site 481805003176 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 481805003177 dimerization interface (closed form) [polypeptide binding]; other site 481805003178 ligand binding site [chemical binding]; other site 481805003179 formate dehydrogenase-H ferredoxin subunit; Provisional; Region: PRK10330 481805003180 RPB11 and RPB3 subunits of RNA polymerase; Region: RNAP_RPB11_RPB3; cl11409 481805003181 Hydrogenase maturation factor [Posttranslational modification, protein turnover, chaperones]; Region: HypF; COG0068 481805003182 Acylphosphatase; Region: Acylphosphatase; pfam00708 481805003183 HypF finger; Region: zf-HYPF; pfam07503 481805003184 HypF finger; Region: zf-HYPF; pfam07503 481805003185 Telomere recombination; Region: Sua5_yciO_yrdC; pfam01300 481805003186 NADH:flavorubredoxin oxidoreductase; Provisional; Region: PRK04965 481805003187 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805003188 anaerobic nitric oxide reductase flavorubredoxin; Provisional; Region: PRK05452 481805003189 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 481805003190 Flavodoxin-like fold; Region: Flavodoxin_2; cl00438 481805003191 Rubredoxin; nonheme iron binding domains containing a [Fe(SCys)4] center. Rubredoxins are small nonheme iron proteins. The iron atom is coordinated by four cysteine residues (Fe(S-Cys)4), but iron can also be replaced by cobalt, nickel or zinc. They are...; Region: rubredoxin; cd00730 481805003192 iron binding site [ion binding]; other site 481805003193 anaerobic nitric oxide reductase transcription regulator; Provisional; Region: PRK05022 481805003194 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 481805003195 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805003196 Walker A motif; other site 481805003197 ATP binding site [chemical binding]; other site 481805003198 Walker B motif; other site 481805003199 arginine finger; other site 481805003200 D-arabinose 5-phosphate isomerase; Provisional; Region: gutQ; PRK11543 481805003201 KpsF-like protein. KpsF is an arabinose-5-phosphate isomerase which contains SIS (Sugar ISomerase) domains. SIS domains are found in many phosphosugar isomerases and phosphosugar binding proteins. KpsF catalyzes the reversible reaction of ribulose...; Region: SIS_Kpsf; cd05014 481805003202 putative active site [active] 481805003203 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with KpsF/GutQ domains in the API [A5P (D-arabinose 5-phosphate) isomerase] protein. These APIs catalyze the conversion of the pentose pathway...; Region: CBS_pair_KpsF_GutQ_assoc; cd04604 481805003204 DNA-bindng transcriptional repressor SrlR; Provisional; Region: srlR; PRK10434 481805003205 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 481805003206 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481805003207 DNA-binding transcriptional activator GutM; Provisional; Region: PRK10234 481805003208 sorbitol-6-phosphate dehydrogenase; Provisional; Region: PRK12384 481805003209 Sorbitol 6-phosphate dehydrogenase (SDH), classical (c) SDRs; Region: SDH_SDR_c_like; cd05322 481805003210 putative NAD(P) binding site [chemical binding]; other site 481805003211 active site 481805003212 PTS system glucitol/sorbitol-specific transporter subunit IIA; Provisional; Region: PRK10377 481805003213 PTS system, glucitol/sorbitol-specific, IIBC component; Region: EIIBC-GUT; TIGR00825 481805003214 Sorbitol phosphotransferase enzyme II N-terminus; Region: EIIBC-GUT_N; pfam03612 481805003215 Sorbitol phosphotransferase enzyme II C-terminus; Region: EIIBC-GUT_C; pfam07663 481805003216 PTS system, glucitol/sorbitol-specific, IIC component; Region: EII-GUT; TIGR00821 481805003217 Transglycosylase SLT domain; Region: SLT_2; pfam13406 481805003218 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 481805003219 N-acetyl-D-glucosamine binding site [chemical binding]; other site 481805003220 hypothetical protein; Validated; Region: PRK03661 481805003221 recombinase A; Provisional; Region: recA; PRK09354 481805003222 RecA is a bacterial enzyme which has roles in homologous recombination, DNA repair, and the induction of the SOS response. RecA couples ATP hydrolysis to DNA strand exchange; Region: recA; cd00983 481805003223 hexamer interface [polypeptide binding]; other site 481805003224 Walker A motif; other site 481805003225 ATP binding site [chemical binding]; other site 481805003226 Walker B motif; other site 481805003227 recombination regulator RecX; Reviewed; Region: recX; PRK00117 481805003228 alanyl-tRNA synthetase; Reviewed; Region: alaS; PRK00252 481805003229 Alanyl-tRNA synthetase (AlaRS) class II core catalytic domain. AlaRS is a homodimer. It is responsible for the attachment of alanine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: AlaRS_core; cd00673 481805003230 motif 1; other site 481805003231 active site 481805003232 motif 2; other site 481805003233 motif 3; other site 481805003234 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; smart00863 481805003235 DHHA1 domain; Region: DHHA1; pfam02272 481805003236 carbon storage regulator; Provisional; Region: PRK01712 481805003237 fructose-1-P/6-phosphogluconate phosphatase; Provisional; Region: PRK10725 481805003238 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805003239 motif II; other site 481805003240 Predicted membrane protein [Function unknown]; Region: COG1238 481805003241 glutamate--cysteine ligase; Provisional; Region: PRK02107 481805003242 S-ribosylhomocysteinase; Provisional; Region: PRK02260 481805003243 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 481805003244 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805003245 putative substrate translocation pore; other site 481805003246 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805003247 multidrug efflux system protein EmrA; Provisional; Region: PRK15136 481805003248 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481805003249 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805003250 transcriptional repressor MprA; Provisional; Region: PRK10870 481805003251 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481805003252 putative L-valine exporter; Provisional; Region: PRK10408 481805003253 Predicted branched-chain amino acid permease (azaleucine resistance) [Amino acid transport and metabolism]; Region: AzlC; COG1296 481805003254 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 481805003255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805003256 glycine betaine transporter periplasmic subunit; Provisional; Region: proX; PRK11119 481805003257 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 481805003258 glycine betaine transporter membrane protein; Provisional; Region: PRK10952 481805003259 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805003260 dimer interface [polypeptide binding]; other site 481805003261 conserved gate region; other site 481805003262 putative PBP binding loops; other site 481805003263 ABC-ATPase subunit interface; other site 481805003264 glycine betaine transporter ATP-binding subunit; Provisional; Region: PRK10070 481805003265 ATP-binding cassette domain of the osmoprotectant proline/glycine betaine uptake system; Region: ABC_Pro_Gly_Betaine; cd03294 481805003266 Walker A/P-loop; other site 481805003267 ATP binding site [chemical binding]; other site 481805003268 Q-loop/lid; other site 481805003269 ABC transporter signature motif; other site 481805003270 Walker B; other site 481805003271 D-loop; other site 481805003272 H-loop/switch region; other site 481805003273 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in association with the ABC transporter OpuCA. OpuCA is the ATP binding component of a bacterial solute transporter that serves a protective role to cells growing...; Region: CBS_pair_ABC_OpuCA_assoc2; cd04583 481805003274 ribonucleotide-diphosphate reductase subunit beta; Provisional; Region: nrdF2; PRK13966 481805003275 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 481805003276 dimer interface [polypeptide binding]; other site 481805003277 putative radical transfer pathway; other site 481805003278 diiron center [ion binding]; other site 481805003279 tyrosyl radical; other site 481805003280 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK08188 481805003281 Ribonucleotide reductase N-terminal; Region: RNR_N; pfam08343 481805003282 Class I ribonucleotide reductase; Region: RNR_I; cd01679 481805003283 active site 481805003284 dimer interface [polypeptide binding]; other site 481805003285 catalytic residues [active] 481805003286 effector binding site; other site 481805003287 Ribonucleotide reductase and Pyruvate formate lyase; Region: RNR_PFL; cl09939 481805003288 ribonucleotide reductase stimulatory protein; Reviewed; Region: nrdI; PRK03600 481805003289 NrdH-redoxin (NrdH) family; NrdH is a small monomeric protein with a conserved redox active CXXC motif within a TRX fold, characterized by a glutaredoxin (GRX)-like sequence and TRX-like activity profile. In vitro, it displays protein disulfide reductase...; Region: NrdH; cd02976 481805003290 catalytic residues [active] 481805003291 hypothetical protein; Provisional; Region: PRK10132 481805003292 hypothetical protein; Provisional; Region: PRK10556 481805003293 Protein of unknown function (DUF1144); Region: DUF1144; pfam06610 481805003294 DNA binding protein, nucleoid-associated; Provisional; Region: PRK10328 481805003295 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 481805003296 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YgaP, and similar uncharacterized putative rhodanese-related sulfurtransferases; Region: RHOD_YgaP; cd01527 481805003297 active site residue [active] 481805003298 Protein of unknown function (DUF2892); Region: DUF2892; pfam11127 481805003299 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481805003300 dimerization interface [polypeptide binding]; other site 481805003301 putative DNA binding site [nucleotide binding]; other site 481805003302 Transcriptional regulators [Transcription]; Region: MarR; COG1846 481805003303 putative Zn2+ binding site [ion binding]; other site 481805003304 Uncharacterized homolog of Blt101 [Function unknown]; Region: COG0401 481805003305 LysM domain/BON superfamily protein; Provisional; Region: PRK11198 481805003306 bacterial OsmY and nodulation domain; Region: BON; smart00749 481805003307 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481805003308 DNA-binding transcriptional regulator CsiR; Provisional; Region: PRK11534 481805003309 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805003310 DNA-binding site [nucleotide binding]; DNA binding site 481805003311 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 481805003312 gamma-aminobutyrate transporter; Provisional; Region: PRK10197 481805003313 4-aminobutyrate aminotransferase; Validated; Region: PRK08088 481805003314 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 481805003315 inhibitor-cofactor binding pocket; inhibition site 481805003316 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805003317 catalytic residue [active] 481805003318 succinate-semialdehyde dehydrogenase I; Provisional; Region: gabD; PRK11241 481805003319 Mitochondrial succinate-semialdehyde dehydrogenase and ALDH family members 5A1 and 5F1-like; Region: ALDH_F5_SSADH_GabD; cd07103 481805003320 tetramerization interface [polypeptide binding]; other site 481805003321 NAD(P) binding site [chemical binding]; other site 481805003322 catalytic residues [active] 481805003323 Predicted dehydrogenase [General function prediction only]; Region: COG0579 481805003324 hydroxyglutarate oxidase; Provisional; Region: PRK11728 481805003325 Clavaminic acid synthetase (CAS) -like; CAS is a trifunctional Fe(II)/ 2-oxoglutarate (2OG) oxygenase carrying out three reactions in the biosynthesis of clavulanic acid, an inhibitor of class A serine beta-lactamases. In general, Fe(II)-2OG oxygenases...; Region: CAS_like; cd00250 481805003326 substrate binding pocket [chemical binding]; other site 481805003327 active site 481805003328 iron coordination sites [ion binding]; other site 481805003329 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 481805003330 Glycosidases [Carbohydrate transport and metabolism]; Region: AmyA; COG0366 481805003331 active site 481805003332 catalytic site [active] 481805003333 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 481805003334 hypothetical protein; Provisional; Region: PRK09945 481805003335 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 481805003336 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 481805003337 Autotransporter beta-domain; Region: Autotransporter; pfam03797 481805003338 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4643 481805003339 Zinc-binding domain of primase-helicase; Region: Prim_Zn_Ribbon; smart00778 481805003340 TOPRIM_primases: The topoisomerase-primase (TORPIM) nucleotidyl transferase/hydrolase domain found in the active site regions of bacterial DnaG-type primases and their homologs. Primases synthesize RNA primers for the initiation of DNA replication. DnaG...; Region: TOPRIM_primases; cd01029 481805003341 active site 481805003342 metal binding site [ion binding]; metal-binding site 481805003343 interdomain interaction site; other site 481805003344 D5 N terminal like; Region: D5_N; smart00885 481805003345 phage/plasmid primase, P4 family, C-terminal domain; Region: primase_Cterm; TIGR01613 481805003346 Poxvirus D5 protein-like; Region: Pox_D5; pfam03288 481805003347 Ash protein family; Region: Phage_ASH; pfam10554 481805003348 Prophage CP4-57 regulatory protein (AlpA); Region: Phage_AlpA; pfam05930 481805003349 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 481805003350 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 481805003351 Phage polarity suppression protein (Psu); Region: Psu; pfam07455 481805003352 integrase; Provisional; Region: PRK09692 481805003353 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 481805003354 active site 481805003355 Int/Topo IB signature motif; other site 481805003356 Small protein B (SmpB) is a component of the trans-translation system in prokaryotes for releasing stalled ribosome from damaged messenger RNAs; Region: SmpB; cd09294 481805003357 SmpB-tmRNA interface; other site 481805003358 Coenzyme Q-binding protein COQ10p and similar proteins; Region: COQ10p_like; cd07813 481805003359 putative coenzyme Q binding site [chemical binding]; other site 481805003360 hypothetical protein; Validated; Region: PRK01777 481805003361 outer membrane biogenesis protein BamE; Provisional; Region: PRK11548 481805003362 SmpA / OmlA family; Region: SmpA_OmlA; pfam04355 481805003363 recombination and repair protein; Provisional; Region: PRK10869 481805003364 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 481805003365 Walker A/P-loop; other site 481805003366 ATP binding site [chemical binding]; other site 481805003367 Q-loop/lid; other site 481805003368 ATP-binding cassette domain of RecN; Region: ABC_RecN; cd03241 481805003369 Q-loop/lid; other site 481805003370 ABC transporter signature motif; other site 481805003371 Walker B; other site 481805003372 D-loop; other site 481805003373 H-loop/switch region; other site 481805003374 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK03378 481805003375 inorganic polyphosphate/ATP-NAD kinase; Provisional; Region: ppnK; PRK02231 481805003376 Molecular chaperone GrpE (heat shock protein) [Posttranslational modification, protein turnover, chaperones]; Region: GrpE; COG0576 481805003377 GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain of Hsp70 catalyzing the dissociation of ADP, which enables rebinding of ATP, one step in the Hsp70 reaction cycle in protein folding; Region: GrpE; cd00446 481805003378 dimer interface [polypeptide binding]; other site 481805003379 hsp70 (ATPase domain) interactions [polypeptide binding]; other site 481805003380 hypothetical protein; Provisional; Region: PRK11573 481805003381 Domain of unknown function DUF21; Region: DUF21; pfam01595 481805003382 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 481805003383 Transporter associated domain; Region: CorC_HlyC; smart01091 481805003384 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4137 481805003385 signal recognition particle protein; Provisional; Region: PRK10867 481805003386 SRP54-type protein, helical bundle domain; Region: SRP54_N; smart00963 481805003387 The signal recognition particle (SRP) mediates the transport to or across the plasma membrane in bacteria and the endoplasmic reticulum in eukaryotes. SRP recognizes N-terminal sighnal sequences of newly synthesized polypeptides at the ribosome. The...; Region: SRP; cd03115 481805003388 P loop; other site 481805003389 GTP binding site [chemical binding]; other site 481805003390 Signal peptide binding domain; Region: SRP_SPB; pfam02978 481805003391 30S ribosomal protein S16; Reviewed; Region: rpsP; PRK00040 481805003392 16S rRNA-processing protein RimM; Provisional; Region: rimM; PRK00122 481805003393 RimM N-terminal domain; Region: RimM; pfam01782 481805003394 PRC-barrel domain; Region: PRC; pfam05239 481805003395 tRNA (guanine-N(1)-)-methyltransferase; Reviewed; Region: trmD; PRK00026 481805003396 50S ribosomal protein L19; Provisional; Region: rplS; PRK05338 481805003397 putative outer membrane lipoprotein; Provisional; Region: PRK09967 481805003398 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 481805003399 ligand binding site [chemical binding]; other site 481805003400 putative inner membrane diguanylate cyclase; Provisional; Region: PRK09966 481805003401 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805003402 metal binding site [ion binding]; metal-binding site 481805003403 active site 481805003404 I-site; other site 481805003405 Domain of unknown function (DUF4154); Region: DUF4154; pfam13689 481805003406 lipoprotein; Provisional; Region: PRK11443 481805003407 Protein of unknown function (DUF2799); Region: DUF2799; pfam10973 481805003408 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12755 481805003409 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 481805003410 bifunctional chorismate mutase/prephenate dehydrogenase; Provisional; Region: tyrA; PRK11199 481805003411 chorismate mutase domain of T-protein; Region: CM_T; TIGR01799 481805003412 prephenate dehydrogenase; Validated; Region: PRK08507 481805003413 bifunctional chorismate mutase/prephenate dehydratase; Provisional; Region: pheA; PRK10622 481805003414 chorismate mutase domain of proteobacterial P-protein, clade 1; Region: CM_P_1; TIGR01797 481805003415 Prephenate dehydratase; Region: PDT; pfam00800 481805003416 C-terminal ACT domain of the bifunctional chorismate mutase-prephenate dehydratase (CM-PDT) enzyme and the prephenate dehydratase (PDT) enzyme; Region: ACT_CM-PDT; cd04905 481805003417 putative L-Phe binding site [chemical binding]; other site 481805003418 RaiA ("ribosome-associated inhibitor A", also known as Protein Y (PY), YfiA, and SpotY, is a stress-response protein that binds the ribosomal subunit interface and arrests translation by interfering with aminoacyl-tRNA binding to the ribosomal...; Region: RaiA; cd00552 481805003419 30S subunit binding site; other site 481805003420 outer membrane biogenesis protein BamD; Provisional; Region: PRK10866 481805003421 Protein of unknown function (DUF3897); Region: DUF3897; cl17494 481805003422 23S rRNA pseudouridine synthase D; Provisional; Region: rluD; PRK11180 481805003423 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481805003424 RNA binding surface [nucleotide binding]; other site 481805003425 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 481805003426 active site 481805003427 hypothetical protein; Provisional; Region: PRK10723 481805003428 Multicopper polyphenol oxidase (laccase) [Secondary metabolites biosynthesis, transport and catabolism]; Region: yfiH; COG1496 481805003429 protein disaggregation chaperone; Provisional; Region: PRK10865 481805003430 Clp amino terminal domain; Region: Clp_N; pfam02861 481805003431 Clp amino terminal domain; Region: Clp_N; pfam02861 481805003432 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805003433 Walker A motif; other site 481805003434 ATP binding site [chemical binding]; other site 481805003435 Walker B motif; other site 481805003436 arginine finger; other site 481805003437 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805003438 Walker A motif; other site 481805003439 ATP binding site [chemical binding]; other site 481805003440 Walker B motif; other site 481805003441 arginine finger; other site 481805003442 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; pfam10431 481805003443 alpha-ketoglutarate transporter; Provisional; Region: PRK10406 481805003444 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805003445 putative substrate translocation pore; other site 481805003446 lipoprotein; Provisional; Region: PRK10759 481805003447 phosphatidylserine synthase; Provisional; Region: pssA; PRK09428 481805003448 Catalytic domain, repeat 1, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_1; cd09134 481805003449 domain interface [polypeptide binding]; other site 481805003450 putative active site [active] 481805003451 catalytic site [active] 481805003452 Catalytic domain, repeat 2, of phosphatidylserine synthases from gram-negative bacteria; Region: PLDc_PSS_G_neg_2; cd09136 481805003453 domain interface [polypeptide binding]; other site 481805003454 putative active site [active] 481805003455 catalytic site [active] 481805003456 Acyl-CoA synthetase (NDP forming) [Energy production and conversion]; Region: COG1042 481805003457 CoA binding domain; Region: CoA_binding_2; pfam13380 481805003458 Succinyl-CoA ligase like flavodoxin domain; Region: Succ_CoA_lig; pfam13607 481805003459 ATP-grasp domain; Region: ATP-grasp_5; pfam13549 481805003460 Acetyltransferase (GNAT) domain; Region: Acetyltransf_3; pfam13302 481805003461 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481805003462 Uncharacterized conserved protein [Function unknown]; Region: COG3148 481805003463 thioredoxin 2; Provisional; Region: PRK10996 481805003464 zinc-ribbon domain; Region: zinc_ribbon_5; cl11777 481805003465 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 481805003466 catalytic residues [active] 481805003467 putative methyltransferase; Provisional; Region: PRK10864 481805003468 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; pfam08032 481805003469 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 481805003470 Family 1 of Uracil-DNA glycosylase (UDG) enzymes; Region: UDG_F1; cd10027 481805003471 ligand binding site [chemical binding]; other site 481805003472 active site 481805003473 UGI interface [polypeptide binding]; other site 481805003474 catalytic site [active] 481805003475 autonomous glycyl radical cofactor GrcA; Provisional; Region: PRK11127 481805003476 cysteine/O-acetylserine exporter; Provisional; Region: PRK10323 481805003477 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481805003478 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805003479 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481805003480 dimerization interface [polypeptide binding]; other site 481805003481 ATP-dependent RNA helicase SrmB; Provisional; Region: PRK11192 481805003482 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 481805003483 ATP binding site [chemical binding]; other site 481805003484 Mg++ binding site [ion binding]; other site 481805003485 motif III; other site 481805003486 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805003487 nucleotide binding region [chemical binding]; other site 481805003488 ATP-binding site [chemical binding]; other site 481805003489 Predicted O-methyltransferase [General function prediction only]; Region: COG4123 481805003490 Methyltransferase domain; Region: Methyltransf_26; pfam13659 481805003491 L-aspartate oxidase; Provisional; Region: PRK09077 481805003492 L-aspartate oxidase; Provisional; Region: PRK06175 481805003493 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 481805003494 RNA polymerase sigma factor RpoE; Region: RpoE_Sigma70; TIGR02939 481805003495 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481805003496 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481805003497 DNA binding residues [nucleotide binding] 481805003498 anti-RNA polymerase sigma factor SigE; Provisional; Region: PRK10863 481805003499 Anti sigma-E protein RseA, N-terminal domain; Region: RseA_N; pfam03872 481805003500 Anti sigma-E protein RseA, C-terminal domain; Region: RseA_C; pfam03873 481805003501 Negative regulator of sigma E activity [Signal transduction mechanisms]; Region: RseB; COG3026 481805003502 anti-sigma E factor; Provisional; Region: rseB; PRK09455 481805003503 SoxR reducing system protein RseC; Provisional; Region: PRK10862 481805003504 GTP-binding protein LepA; Provisional; Region: PRK05433 481805003505 LepA also known as Elongation Factor 4 (EF4); Region: LepA; cd01890 481805003506 G1 box; other site 481805003507 putative GEF interaction site [polypeptide binding]; other site 481805003508 GTP/Mg2+ binding site [chemical binding]; other site 481805003509 Switch I region; other site 481805003510 G2 box; other site 481805003511 G3 box; other site 481805003512 Switch II region; other site 481805003513 G4 box; other site 481805003514 G5 box; other site 481805003515 lepA_II: This subfamily represents the domain II of LepA, a GTP-binding protein localized in the cytoplasmic membrane. The N-terminal domain of LepA shares regions of homology to translation factors. In terms of interaction with the ribosome, EF-G, EF-Tu...; Region: lepA_II; cd03699 481805003516 lepA_C: This family represents the C-terminal region of LepA, a GTP-binding protein localized in the cytoplasmic membrane. LepA is ubiquitous in Bacteria and Eukaryota (e.g. Saccharomyces cerevisiae GUF1p), but is missing from Archaea. LepA exhibits...; Region: lepA_C; cd03709 481805003517 GTP-binding protein LepA C-terminus; Region: LepA_C; pfam06421 481805003518 signal peptidase I; Provisional; Region: PRK10861 481805003519 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 481805003520 Catalytic site [active] 481805003521 The S26 Type I signal peptidase (SPase; LepB; leader peptidase B; leader peptidase I; EC 3.4.21.89) family members are essential membrane-bound serine proteases that function to cleave the amino-terminal signal peptide extension from proteins that are...; Region: S26_SPase_I; cd06530 481805003522 rnc leader sequence as predicted by Rfam (RF00552), score 252.26; rnc leader sequence 481805003523 ribonuclease III; Reviewed; Region: rnc; PRK00102 481805003524 RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in...; Region: RIBOc; cd00593 481805003525 dimerization interface [polypeptide binding]; other site 481805003526 active site 481805003527 metal binding site [ion binding]; metal-binding site 481805003528 Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Found in a variety of proteins including dsRNA dependent protein kinase PKR, RNA helicases, Drosophila staufen protein, E. coli RNase III; Region: DSRM; cd00048 481805003529 dsRNA binding site [nucleotide binding]; other site 481805003530 GTPase Era; Reviewed; Region: era; PRK00089 481805003531 E. coli Ras-like protein (Era) is a multifunctional GTPase; Region: Era; cd04163 481805003532 G1 box; other site 481805003533 GTP/Mg2+ binding site [chemical binding]; other site 481805003534 Switch I region; other site 481805003535 G2 box; other site 481805003536 Switch II region; other site 481805003537 G3 box; other site 481805003538 G4 box; other site 481805003539 G5 box; other site 481805003540 KH domain; Region: KH_2; pfam07650 481805003541 DNA repair protein RecO; Reviewed; Region: recO; PRK00085 481805003542 Recombination protein O N terminal; Region: RecO_N; pfam11967 481805003543 Recombination protein O C terminal; Region: RecO_C; pfam02565 481805003544 Pyridoxine 5'-phosphate (PNP) synthase domain; pyridoxal 5'-phosphate is the active form of vitamin B6 that acts as an essential, ubiquitous coenzyme in amino acid metabolism. In bacteria, formation of pyridoxine 5'-phosphate is a step in...; Region: PNPsynthase; cd00003 481805003545 active site 481805003546 hydrophilic channel; other site 481805003547 dimerization interface [polypeptide binding]; other site 481805003548 catalytic residues [active] 481805003549 active site lid [active] 481805003550 holo-[acyl-carrier-protein] synthase; Region: acpS; TIGR00516 481805003551 4Fe-4S dicluster domain; Region: Fer4_7; pfam12838 481805003552 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 481805003553 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11557 481805003554 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 481805003555 putative active site [active] 481805003556 hypothetical protein; Provisional; Region: PRK11590 481805003557 Phosphoserine phosphatase [Amino acid transport and metabolism]; Region: SerB; COG0560 481805003558 Nucleoside deaminases include adenosine, guanine and cytosine deaminases. These enzymes are Zn dependent and catalyze the deamination of nucleosides. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a...; Region: nucleoside_deaminase; cd01285 481805003559 nucleoside/Zn binding site; other site 481805003560 dimer interface [polypeptide binding]; other site 481805003561 catalytic motif [active] 481805003562 membrane-bound lytic transglycosylase F; Provisional; Region: PRK10859 481805003563 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805003564 substrate binding pocket [chemical binding]; other site 481805003565 membrane-bound complex binding site; other site 481805003566 hinge residues; other site 481805003567 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 481805003568 N-acetyl-D-glucosamine binding site [chemical binding]; other site 481805003569 catalytic residue [active] 481805003570 phosphoribosylformylglycinamidine synthase; Provisional; Region: PRK05297 481805003571 PurL subunit of the formylglycinamide ribonucleotide amidotransferase (FGAR-AT), first repeat. FGAR-AT catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to formylglycinamidine ribonucleotide (FGAM), ADP; Region: PurL_repeat1; cd02203 481805003572 dimerization interface [polypeptide binding]; other site 481805003573 ATP binding site [chemical binding]; other site 481805003574 AIR (aminoimidazole ribonucleotide) synthase related protein. This family includes Hydrogen expression/formation protein HypE, AIR synthases, FGAM (formylglycinamidine ribonucleotide) synthase and Selenophosphate synthetase (SelD). The N-terminal domain...; Region: PurM-like; cl10019 481805003575 dimerization interface [polypeptide binding]; other site 481805003576 ATP binding site [chemical binding]; other site 481805003577 Type 1 glutamine amidotransferase (GATase1)-like domain found in Formylglycinamide ribonucleotide amidotransferase; Region: GATase1_FGAR_AT; cd01740 481805003578 putative active site [active] 481805003579 catalytic triad [active] 481805003580 Signal transduction histidine kinase [Signal transduction mechanisms]; Region: BaeS; COG0642 481805003581 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805003582 dimer interface [polypeptide binding]; other site 481805003583 phosphorylation site [posttranslational modification] 481805003584 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805003585 ATP binding site [chemical binding]; other site 481805003586 Mg2+ binding site [ion binding]; other site 481805003587 G-X-G motif; other site 481805003588 hypothetical protein; Provisional; Region: PRK10722 481805003589 response regulator GlrR; Provisional; Region: PRK15115 481805003590 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805003591 active site 481805003592 phosphorylation site [posttranslational modification] 481805003593 intermolecular recognition site; other site 481805003594 dimerization interface [polypeptide binding]; other site 481805003595 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805003596 Walker A motif; other site 481805003597 ATP binding site [chemical binding]; other site 481805003598 Walker B motif; other site 481805003599 arginine finger; other site 481805003600 nitrogen regulatory protein P-II 1; Provisional; Region: PRK10858 481805003601 Nitrogen regulatory protein P-II; Region: P-II; smart00938 481805003602 bifunctional nitric oxide dioxygenase/dihydropteridine reductase 2; Provisional; Region: PRK13289 481805003603 Globins are heme proteins, which bind and transport oxygen. This family summarizes a diverse set of homologous protein domains, including: (1) tetrameric vertebrate hemoglobins, which are the major protein component of erythrocytes and transport oxygen...; Region: globin; cd01040 481805003604 heme-binding site [chemical binding]; other site 481805003605 FAD_NAD(P)H binding domain of flavohemoglobin. Flavohemoglobins have a globin domain containing a B-type heme fused with a ferredoxin reductase-like FAD/NAD-binding domain. Flavohemoglobins detoxify nitric oxide (NO) via an NO dioxygenase reaction. The...; Region: flavohem_like_fad_nad_binding; cd06184 481805003606 FAD binding pocket [chemical binding]; other site 481805003607 FAD binding motif [chemical binding]; other site 481805003608 phosphate binding motif [ion binding]; other site 481805003609 beta-alpha-beta structure motif; other site 481805003610 NAD binding pocket [chemical binding]; other site 481805003611 Heme binding pocket [chemical binding]; other site 481805003612 serine hydroxymethyltransferase; Reviewed; Region: glyA; PRK00011 481805003613 Serine-glycine hydroxymethyltransferase (SHMT). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). SHMT carries out interconversion of serine and glycine; it catalyzes the transfer of hydroxymethyl...; Region: SHMT; cd00378 481805003614 dimer interface [polypeptide binding]; other site 481805003615 active site 481805003616 glycine-pyridoxal phosphate binding site [chemical binding]; other site 481805003617 folate binding site [chemical binding]; other site 481805003618 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 481805003619 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 481805003620 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481805003621 nucleotide binding site [chemical binding]; other site 481805003622 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481805003623 TPR motif; other site 481805003624 Tetratricopeptide repeat; Region: TPR_16; pfam13432 481805003625 binding surface 481805003626 TPR repeat; Region: TPR_11; pfam13414 481805003627 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481805003628 TPR motif; other site 481805003629 binding surface 481805003630 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: RbsB; COG1879 481805003631 Periplasmic sugar-binding domain of active transport systems that are members of the type I periplasmic binding protein (PBP1) superfamily; Region: PBP1_ABC_sugar_binding_like; cd01536 481805003632 ligand binding site [chemical binding]; other site 481805003633 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 481805003634 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 481805003635 Walker A/P-loop; other site 481805003636 ATP binding site [chemical binding]; other site 481805003637 Q-loop/lid; other site 481805003638 ABC transporter signature motif; other site 481805003639 Walker B; other site 481805003640 D-loop; other site 481805003641 H-loop/switch region; other site 481805003642 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481805003643 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481805003644 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481805003645 TM-ABC transporter signature motif; other site 481805003646 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 481805003647 L-threonine dehydrogenase (TDH)-like; Region: THR_DH_like; cd08239 481805003648 putative NAD(P) binding site [chemical binding]; other site 481805003649 catalytic Zn binding site [ion binding]; other site 481805003650 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 481805003651 active site 481805003652 catalytic residues [active] 481805003653 Predicted membrane protein [Function unknown]; Region: COG2259 481805003654 phenylpropionate dioxygenase ferredoxin reductase subunit; Provisional; Region: PRK09754 481805003655 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805003656 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase; Provisional; Region: PRK06200 481805003657 cis-biphenyl-2,3-dihydrodiol-2,3-dehydrogenase (BphB)-like, classical (c) SDRs; Region: BphB-like_SDR_c; cd05348 481805003658 NAD binding site [chemical binding]; other site 481805003659 active site 481805003660 Rieske non-heme iron oxygenase (RO) family, Rieske ferredoxin component; composed of the Rieske ferredoxin component of some three-component RO systems including biphenyl dioxygenase (BPDO) and carbazole 1,9a-dioxygenase (CARDO). The RO family comprise a...; Region: Rieske_RO_ferredoxin; cd03528 481805003661 [2Fe-2S] cluster binding site [ion binding]; other site 481805003662 Ring hydroxylating dioxygenase beta subunit. This subunit has a similar structure to NTF-2, Ketosteroid isomerase and scytalone dehydratase.The degradation of aromatic compounds by aerobic bacteria frequently begins with the dihydroxylation of the...; Region: ring_hydroxylating_dioxygenases_beta; cd00667 481805003663 inter-subunit interface; other site 481805003664 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 481805003665 Rieske domain; a [2Fe-2S] cluster binding domain commonly found in Rieske non-heme iron oxygenase (RO) systems such as naphthalene and biphenyl dioxygenases, as well as in plant/cyanobacterial chloroplast b6f and mitochondrial cytochrome bc(1) complexes; Region: Rieske; cl00938 481805003666 iron-sulfur cluster [ion binding]; other site 481805003667 [2Fe-2S] cluster binding site [ion binding]; other site 481805003668 C-terminal catalytic domain of the oxygenase alpha subunit of naphthalene 1,2-dioxygenase (NDO) and related aromatic ring hydroxylating dioxygenases; Region: RHO_alpha_C_NDO-like; cd08881 481805003669 beta subunit interface [polypeptide binding]; other site 481805003670 alpha subunit interface [polypeptide binding]; other site 481805003671 active site 481805003672 substrate binding site [chemical binding]; other site 481805003673 Fe binding site [ion binding]; other site 481805003674 DNA-binding transcriptional regulator HcaR; Provisional; Region: PRK09906 481805003675 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805003676 The C-terminal substrate binding domain of LysR-type transcriptional regulator HcaR in involved in 3-phenylpropionic acid catabolism, contains the type2 periplasmic binding fold; Region: PBP2_HcaR; cd08450 481805003677 putative dimerization interface [polypeptide binding]; other site 481805003678 putative substrate binding pocket [chemical binding]; other site 481805003679 putative 3-phenylpropionic acid transporter; Provisional; Region: PRK11128 481805003680 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805003681 putative substrate translocation pore; other site 481805003682 stationary phase inducible protein CsiE; Provisional; Region: PRK11564 481805003683 PRD domain; Region: PRD; pfam00874 481805003684 PRD domain; Region: PRD; pfam00874 481805003685 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 481805003686 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481805003687 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 481805003688 IMPase, inositol monophosphatase and related domains. A family of Mg++ dependent phosphatases, inhibited by lithium, many of which may act on inositol monophosphate substrate. They dephosphorylate inositol phosphate to generate inositol, which may be...; Region: IMPase; cd01639 481805003689 active site 481805003690 dimerization interface [polypeptide binding]; other site 481805003691 tRNA (cytidine/uridine-2'-O-)-methyltransferase TrmJ; Provisional; Region: PRK15114 481805003692 SpoU rRNA Methylase family; Region: SpoU_methylase; cl17307 481805003693 DNA-binding transcriptional regulator IscR; Provisional; Region: PRK10857 481805003694 Rrf2 family protein; Region: rrf2_super; TIGR00738 481805003695 cysteine desulfurase; Provisional; Region: PRK14012 481805003696 cysteine desulfurase NifS; Region: FeS_nifS; TIGR03402 481805003697 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 481805003698 catalytic residue [active] 481805003699 NifU homolog involved in Fe-S cluster formation [Energy production and conversion]; Region: IscU; COG0822 481805003700 Iron-sulfur cluster scaffold-like proteins; Region: IscU_like; cd06664 481805003701 trimerization site [polypeptide binding]; other site 481805003702 active site 481805003703 iron-sulfur cluster assembly protein; Provisional; Region: iscA; PRK09502 481805003704 co-chaperone HscB; Provisional; Region: hscB; PRK05014 481805003705 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 481805003706 HSP70 interaction site [polypeptide binding]; other site 481805003707 HSCB C-terminal oligomerisation domain; Region: HSCB_C; pfam07743 481805003708 chaperone protein HscA; Provisional; Region: hscA; PRK05183 481805003709 Nucleotide-binding domain of HscA and similar proteins; Region: HscA_like_NBD; cd10236 481805003710 nucleotide binding site [chemical binding]; other site 481805003711 putative NEF/HSP70 interaction site [polypeptide binding]; other site 481805003712 SBD interface [polypeptide binding]; other site 481805003713 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 481805003714 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 481805003715 catalytic loop [active] 481805003716 iron binding site [ion binding]; other site 481805003717 hypothetical protein; Provisional; Region: PRK10721 481805003718 aminopeptidase B; Provisional; Region: PRK05015 481805003719 Peptidase; Region: DUF3663; pfam12404 481805003720 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 481805003721 interface (dimer of trimers) [polypeptide binding]; other site 481805003722 Substrate-binding/catalytic site; other site 481805003723 Zn-binding sites [ion binding]; other site 481805003724 enhanced serine sensitivity protein SseB; Provisional; Region: PRK11611 481805003725 3-mercaptopyruvate sulfurtransferase; Provisional; Region: sseA; PRK11493 481805003726 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 481805003727 active site residue [active] 481805003728 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 481805003729 active site residue [active] 481805003730 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 481805003731 MG2 domain; Region: A2M_N; pfam01835 481805003732 Alpha-2-macroglobulin family; Region: A2M; pfam00207 481805003733 Proteins similar to alpha2-macroglobulin (alpha (2)-M). Alpha (2)-M is a major carrier protein in serum. It is a broadly specific proteinase inhibitor. The structural thioester of alpha (2)-M, is involved in the immobilization and entrapment of...; Region: A2M_like; cd02891 481805003734 surface patch; other site 481805003735 thioester region; other site 481805003736 specificity defining residues; other site 481805003737 penicillin-binding protein 1C; Provisional; Region: PRK11240 481805003738 Transglycosylase; Region: Transgly; pfam00912 481805003739 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 481805003740 Penicillin-Binding Protein C-terminus Family; Region: BiPBP_C; pfam06832 481805003741 Nucleoside diphosphate kinase Group I (NDPk_I)-like: NDP kinase domains are present in a large family of structurally and functionally conserved proteins from bacteria to humans that generally catalyze the transfer of gamma-phosphates of a nucleoside...; Region: NDPk_I; cd04413 481805003742 active site 481805003743 multimer interface [polypeptide binding]; other site 481805003744 ribosomal RNA large subunit methyltransferase N; Provisional; Region: PRK11194 481805003745 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805003746 FeS/SAM binding site; other site 481805003747 cytoskeletal protein RodZ; Provisional; Region: PRK10856 481805003748 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805003749 non-specific DNA binding site [nucleotide binding]; other site 481805003750 salt bridge; other site 481805003751 sequence-specific DNA binding site [nucleotide binding]; other site 481805003752 Domain of unknown function (DUF4115); Region: DUF4115; pfam13464 481805003753 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Reviewed; Region: ispG; PRK00366 481805003754 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 481805003755 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase; Validated; Region: PRK00694 481805003756 histidyl-tRNA synthetase; Reviewed; Region: hisS; PRK00037 481805003757 Class II Histidinyl-tRNA synthetase (HisRS)-like catalytic core domain. HisRS is a homodimer. It is responsible for the attachment of histidine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for...; Region: HisRS-like_core; cd00773 481805003758 dimer interface [polypeptide binding]; other site 481805003759 motif 1; other site 481805003760 active site 481805003761 motif 2; other site 481805003762 motif 3; other site 481805003763 HisRS Histidyl-anticodon binding domain. HisRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: HisRS_anticodon; cd00859 481805003764 anticodon binding site; other site 481805003765 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2976 481805003766 outer membrane biogenesis protein BamB; Provisional; Region: PRK11138 481805003767 PQQ-dependent dehydrogenases and related proteins; Region: PQQ_DH_like; cd00216 481805003768 Trp docking motif [polypeptide binding]; other site 481805003769 active site 481805003770 GTP-binding protein Der; Reviewed; Region: PRK00093 481805003771 EngA1 GTPase contains the first domain of EngA; Region: EngA1; cd01894 481805003772 G1 box; other site 481805003773 GTP/Mg2+ binding site [chemical binding]; other site 481805003774 Switch I region; other site 481805003775 G2 box; other site 481805003776 Switch II region; other site 481805003777 G3 box; other site 481805003778 G4 box; other site 481805003779 G5 box; other site 481805003780 EngA2 GTPase contains the second domain of EngA; Region: EngA2; cd01895 481805003781 G1 box; other site 481805003782 GTP/Mg2+ binding site [chemical binding]; other site 481805003783 Switch I region; other site 481805003784 G2 box; other site 481805003785 G3 box; other site 481805003786 Switch II region; other site 481805003787 G4 box; other site 481805003788 G5 box; other site 481805003789 Protein of unknown function (DUF1407); Region: DUF1407; pfam07191 481805003790 exodeoxyribonuclease VII, large subunit; Region: xseA; TIGR00237 481805003791 ExoVII_LU_OBF: A subfamily of OB folds corresponding to the N-terminal OB-fold domain of Escherichia coli exodeoxyribonuclease VII (ExoVII) large subunit. E. coli ExoVII is composed of two non-identical subunits. E. coli ExoVII is a...; Region: ExoVII_LU_OBF; cd04489 481805003792 generic binding surface II; other site 481805003793 generic binding surface I; other site 481805003794 inosine 5'-monophosphate dehydrogenase; Reviewed; Region: PRK05567 481805003795 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 481805003796 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the inosine 5' monophosphate dehydrogenase (IMPDH) protein. IMPDH is an essential enzyme that catalyzes the first step unique to GTP synthesis, playing a...; Region: CBS_pair_IMPDH; cd04601 481805003797 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 481805003798 active site 481805003799 GMP synthase; Reviewed; Region: guaA; PRK00074 481805003800 Type 1 glutamine amidotransferase (GATase1) domain found in GMP synthetase; Region: GATase1_GMP_Synthase; cd01742 481805003801 AMP/PPi binding site [chemical binding]; other site 481805003802 candidate oxyanion hole; other site 481805003803 catalytic triad [active] 481805003804 potential glutamine specificity residues [chemical binding]; other site 481805003805 The C-terminal domain of GMP synthetase. It contains two subdomains; the ATP pyrophosphatase domain which closes to the N-termial and the dimerization domain at C-terminal end. The ATP-PPase is a twisted, five-stranded parallel beta-sheet sandwiched...; Region: GMP_synthase_C; cd01997 481805003806 ATP Binding subdomain [chemical binding]; other site 481805003807 Ligand Binding sites [chemical binding]; other site 481805003808 Dimerization subdomain; other site 481805003809 Glycine zipper 2TM domain; Region: Rick_17kDa_Anti; cl10470 481805003810 MASE1; Region: MASE1; pfam05231 481805003811 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481805003812 diguanylate cyclase; Region: GGDEF; smart00267 481805003813 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805003814 exopolyphosphatase; Provisional; Region: PRK10854 481805003815 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 481805003816 Polyphosphate kinase [Inorganic ion transport and metabolism]; Region: Ppk; COG0855 481805003817 Polyphosphate kinase N-terminal domain; Region: PP_kinase_N; pfam13089 481805003818 Polyphosphate kinase middle domain; Region: PP_kinase; pfam02503 481805003819 Catalytic C-terminal domain, first repeat, of prokaryotic polyphosphate kinase 1 and similar proteins; Region: PLDc_PPK1_C1; cd09114 481805003820 domain interface [polypeptide binding]; other site 481805003821 active site 481805003822 catalytic site [active] 481805003823 Catalytic domain of phospholipase D superfamily proteins; Region: PLDc_SF; cl15239 481805003824 putative active site [active] 481805003825 catalytic site [active] 481805003826 phosphoribosylglycinamide formyltransferase; Reviewed; Region: purN; PRK05647 481805003827 Phosphoribosylglycinamide formyltransferase (GAR transformylase, GART); Region: FMT_core_GART; cd08645 481805003828 active site 481805003829 substrate binding site [chemical binding]; other site 481805003830 cosubstrate binding site; other site 481805003831 catalytic site [active] 481805003832 phosphoribosylaminoimidazole synthetase; Provisional; Region: PRK05385 481805003833 PurM (Aminoimidazole Ribonucleotide [AIR] synthetase), one of eleven enzymes required for purine biosynthesis, catalyzes the conversion of formylglycinamide ribonucleotide (FGAM) and ATP to AIR, ADP, and Pi, the fifth step in de novo purine biosynthesis; Region: PurM; cd02196 481805003834 dimerization interface [polypeptide binding]; other site 481805003835 putative ATP binding site [chemical binding]; other site 481805003836 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481805003837 active site 481805003838 uracil transporter; Provisional; Region: PRK10720 481805003839 ATPase involved in DNA replication initiation [DNA replication, recombination, and repair]; Region: DnaA; COG0593 481805003840 DNA replication initiation factor; Provisional; Region: PRK08084 481805003841 Arsenate Reductase (ArsC) family, ArsC subfamily; arsenic reductases similar to that encoded by arsC on the R733 plasmid of Escherichia coli. E. coli ArsC catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)], the first step in the...; Region: ArsC_ArsC; cd03034 481805003842 ArsC family; Region: ArsC; pfam03960 481805003843 catalytic residues [active] 481805003844 Putative Zn-dependent protease, contains TPR repeats [General function prediction only]; Region: COG4783 481805003845 Peptidase family M48; Region: Peptidase_M48; cl12018 481805003846 Predicted permease, member of the PurR regulon [General function prediction only]; Region: yhhT; COG0628 481805003847 Domain of unknown function DUF20; Region: UPF0118; pfam01594 481805003848 putative formate transporter; Provisional; Region: focB; PRK09713 481805003849 Transcriptional regulator containing GAF, AAA-type ATPase, and DNA binding domains [Transcription / Signal transduction mechanisms]; Region: FhlA; COG3604 481805003850 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 481805003851 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805003852 Walker A motif; other site 481805003853 ATP binding site [chemical binding]; other site 481805003854 Walker B motif; other site 481805003855 arginine finger; other site 481805003856 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 481805003857 formate hydrogenlyase maturation protein HycH; Provisional; Region: PRK15084 481805003858 Ni,Fe-hydrogenase III small subunit [Energy production and conversion]; Region: COG3260 481805003859 hydrogenase 4 subunit H; Validated; Region: PRK08222 481805003860 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 481805003861 Ni,Fe-hydrogenase III component G [Energy production and conversion]; Region: HycE; COG3262 481805003862 Ni,Fe-hydrogenase III large subunit [Energy production and conversion]; Region: HycE; COG3261 481805003863 NADH dehydrogenase subunit D; Validated; Region: PRK06075; cl17338 481805003864 hydrogenase 4 subunit F; Validated; Region: PRK06458 481805003865 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 481805003866 hydrogenase 4 membrane subunit; Provisional; Region: hyfE; PRK11492 481805003867 hydrogenase 4 subunit D; Validated; Region: PRK06525 481805003868 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 481805003869 hydrogenase 4 subunit B; Validated; Region: PRK06521 481805003870 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 481805003871 Fe-S-cluster-containing hydrogenase components 2 [Energy production and conversion]; Region: HycB; COG1142 481805003872 4Fe-4S binding domain; Region: Fer4; pfam00037 481805003873 Peroxiredoxin [Posttranslational modification, protein turnover, chaperones]; Region: AhpC; COG0450 481805003874 Peroxiredoxin (PRX) family, Bacterioferritin comigratory protein (BCP) subfamily; composed of thioredoxin-dependent thiol peroxidases, widely expressed in pathogenic bacteria, that protect cells against toxicity from reactive oxygen species by reducing...; Region: PRX_BCP; cd03017 481805003875 catalytic triad [active] 481805003876 glycine cleavage system transcriptional repressor; Provisional; Region: gcvR; PRK11589 481805003877 ACT domains that comprise the Glycine Cleavage System Transcriptional Repressor (GcvR) protein, and other related domains; Region: ACT_GcvR_1; cd04893 481805003878 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 481805003879 Dihydrodipicolinate synthase (DHDPS); Region: DHDPS; cd00950 481805003880 dihydrodipicolinate synthase; Region: dapA; TIGR00674 481805003881 dimer interface [polypeptide binding]; other site 481805003882 active site 481805003883 catalytic residue [active] 481805003884 lipoprotein; Provisional; Region: PRK11679 481805003885 NlpB/DapX lipoprotein; Region: Lipoprotein_18; pfam06804 481805003886 phosphoribosylaminoimidazole-succinocarboxamide synthase; Reviewed; Region: PRK09362 481805003887 bacterial and archaeal 5-aminoimidazole-4-(N-succinylcarboxamide) ribonucleotide (SAICAR) synthase; Region: SAICAR_synt_PurC; cd01415 481805003888 ATP binding site [chemical binding]; other site 481805003889 active site 481805003890 substrate binding site [chemical binding]; other site 481805003891 Predicted metalloprotease [General function prediction only]; Region: COG2321 481805003892 Putative neutral zinc metallopeptidase; Region: Zn_peptidase; pfam04228 481805003893 Predicted P-loop ATPase fused to an acetyltransferase [General function prediction only]; Region: COG1444 481805003894 Helicase; Region: Helicase_RecD; pfam05127 481805003895 GNAT acetyltransferase 2; Region: GNAT_acetyltr_2; pfam13718 481805003896 Possible tRNA binding domain; Region: tRNA_bind_2; pfam13725 481805003897 putative hydrolase; Provisional; Region: PRK11460 481805003898 Phospholipase/Carboxylesterase; Region: Abhydrolase_2; pfam02230 481805003899 hypothetical protein; Provisional; Region: PRK13664 481805003900 succinyl-diaminopimelate desuccinylase; Reviewed; Region: PRK13009 481805003901 M20 Peptidase proteobacterial DapE encoded N-succinyl-L,L-diaminopimelic acid desuccinylase; Region: M20_DapE_proteobac; cd03891 481805003902 metal binding site [ion binding]; metal-binding site 481805003903 dimer interface [polypeptide binding]; other site 481805003904 Arsenate Reductase (ArsC) family, Yffb subfamily; Yffb is an uncharacterized bacterial protein encoded by the yffb gene, related to the thioredoxin-fold arsenic reductases, ArsC. The structure of Yffb and the conservation of the catalytic cysteine...; Region: ArsC_Yffb; cd03035 481805003905 ArsC family; Region: ArsC; pfam03960 481805003906 putative catalytic residues [active] 481805003907 aminoglycoside/multidrug efflux system; Provisional; Region: PRK10555 481805003908 Protein export membrane protein; Region: SecD_SecF; cl14618 481805003909 nitrate/nitrite sensor protein NarQ; Provisional; Region: PRK10935 481805003910 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 481805003911 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805003912 dimerization interface [polypeptide binding]; other site 481805003913 Histidine kinase; Region: HisKA_3; pfam07730 481805003914 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805003915 ATP binding site [chemical binding]; other site 481805003916 Mg2+ binding site [ion binding]; other site 481805003917 G-X-G motif; other site 481805003918 putative oxidoreductase Fe-S binding subunit; Reviewed; Region: PRK12769 481805003919 4Fe-4S binding domain; Region: Fer4; pfam00037 481805003920 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481805003921 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805003922 GDP-mannose pyrophosphatase NudK; Provisional; Region: PRK15009 481805003923 ADP-ribose pyrophosphatase (ADPRase) catalyzes the hydrolysis of ADP-ribose and a variety of additional ADP-sugar conjugates to AMP and ribose-5-phosphate. Like other members of the Nudix hydrolase superfamily, it requires a divalent cation, such as Mg2+; Region: ADPRase_NUDT5; cd03424 481805003924 dimer interface [polypeptide binding]; other site 481805003925 ADP-ribose binding site [chemical binding]; other site 481805003926 active site 481805003927 nudix motif; other site 481805003928 metal binding site [ion binding]; metal-binding site 481805003929 Protein of unknown function (DUF1176); Region: DUF1176; pfam06674 481805003930 transketolase; Reviewed; Region: PRK12753 481805003931 Thiamine pyrophosphate (TPP) family, Transketolase (TK) subfamily, TPP-binding module; TK catalyzes the transfer of a two-carbon unit from ketose phosphates to aldose phosphates. In heterotrophic organisms, TK provides a link between glycolysis and the...; Region: TPP_TK; cd02012 481805003932 TPP-binding site [chemical binding]; other site 481805003933 dimer interface [polypeptide binding]; other site 481805003934 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 481805003935 PYR/PP interface [polypeptide binding]; other site 481805003936 dimer interface [polypeptide binding]; other site 481805003937 TPP binding site [chemical binding]; other site 481805003938 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 481805003939 transaldolase-like protein; Provisional; Region: PTZ00411 481805003940 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 481805003941 active site 481805003942 dimer interface [polypeptide binding]; other site 481805003943 catalytic residue [active] 481805003944 bifunctional malic enzyme oxidoreductase/phosphotransacetylase; Reviewed; Region: PRK07232 481805003945 Malic enzyme, N-terminal domain; Region: malic; pfam00390 481805003946 NAD(P) binding domain of malic enzyme (ME), subgroup 2; Region: NAD_bind_2_malic_enz; cd05311 481805003947 putative NAD(P) binding site [chemical binding]; other site 481805003948 Phosphotransacetylase [Energy production and conversion]; Region: Pta; COG0280 481805003949 1,2-propanediol utilization protein U (PduU)/ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain; Region: BMC_PduU-EutS; cd07046 481805003950 putative hexamer interface [polypeptide binding]; other site 481805003951 putative hexagonal pore; other site 481805003952 Rat sarcoma (Ras)-like superfamily of small guanosine triphosphatases (GTPases); Region: Ras_like_GTPase; cd00882 481805003953 G1 box; other site 481805003954 GTP/Mg2+ binding site [chemical binding]; other site 481805003955 G2 box; other site 481805003956 Switch I region; other site 481805003957 G3 box; other site 481805003958 Switch II region; other site 481805003959 G4 box; other site 481805003960 G5 box; other site 481805003961 ethanolamine utilization protein EutQ; Provisional; Region: PRK15457 481805003962 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutQ; COG4766 481805003963 ethanolamine utilization cobalamin adenosyltransferase; Provisional; Region: PRK15020 481805003964 phosphotransacetylase; Reviewed; Region: eutD; PRK09653 481805003965 Carbon dioxide concentrating mechanism/carboxysome shell protein [Secondary metabolites biosynthesis, transport, and catabolism / Energy production and conversion]; Region: CcmK; COG4577 481805003966 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 481805003967 Hexamer interface [polypeptide binding]; other site 481805003968 Hexagonal pore residue; other site 481805003969 Ethanolamine utilisation protein and carboxysome structural protein domain family; Region: EutN_CcmL; cd01614 481805003970 Hexamer/Pentamer interface [polypeptide binding]; other site 481805003971 central pore; other site 481805003972 Ethanolamine utilization protein EutE-like; Region: ALDH_EutE; cd07121 481805003973 putative catalytic cysteine [active] 481805003974 Ethanolamine utilization protein, possible chaperonin [Amino acid transport and metabolism]; Region: EutJ; COG4820 481805003975 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481805003976 nucleotide binding site [chemical binding]; other site 481805003977 ethanol dehydrogenase EutG; Provisional; Region: PRK15454 481805003978 iron-containing alcohol dehydrogenases (Fe-ADH)-like; Region: Fe-ADH; cd08551 481805003979 active site 481805003980 metal binding site [ion binding]; metal-binding site 481805003981 Ethanolamine utilization protein [Amino acid transport and metabolism]; Region: EutH; COG3192 481805003982 reactivating factor for ethanolamine ammonia lyase; Provisional; Region: eutA; PRK10719 481805003983 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cl17200 481805003984 sequence-specific DNA binding site [nucleotide binding]; other site 481805003985 salt bridge; other site 481805003986 HNH endonuclease; Region: HNH_3; pfam13392 481805003987 integrase; Provisional; Region: PRK09692 481805003988 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 481805003989 active site 481805003990 Int/Topo IB signature motif; other site 481805003991 Ethanolamine ammonia-lyase, large subunit [Amino acid transport and metabolism]; Region: EutB; COG4303 481805003992 Ethanolamine ammonia lyase large subunit (EutB); Region: EutB; pfam06751 481805003993 Ethanolamine ammonia-lyase, small subunit [Amino acid transport and metabolism]; Region: EutC; COG4302 481805003994 ethanolamine utilization protein EutL; Provisional; Region: PRK15405 481805003995 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 1; Region: BMC_EutL_repeat1; cd07049 481805003996 putative hexamer interface [polypeptide binding]; other site 481805003997 putative hexagonal pore; other site 481805003998 ethanolamine utilization protein S (EutS), Bacterial Micro-Compartment (BMC) domain repeat 2; Region: BMC_EutL_repeat2; cd07050 481805003999 putative hexamer interface [polypeptide binding]; other site 481805004000 putative hexagonal pore; other site 481805004001 carboxysome structural protein EutK; Provisional; Region: PRK15466 481805004002 Carbon dioxide concentrating mechanism K (CcmK)-like proteins, Bacterial Micro-Compartment (BMC) domain; Region: BMC_CcmK_like; cd07045 481805004003 Hexamer interface [polypeptide binding]; other site 481805004004 Hexagonal pore residue; other site 481805004005 transcriptional regulator EutR; Provisional; Region: PRK10130 481805004006 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805004007 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805004008 coproporphyrinogen III oxidase; Provisional; Region: PRK05330 481805004009 Coproporphyrinogen III oxidase; Region: Coprogen_oxidas; pfam01218 481805004010 N-acetylmuramoyl-l-alanine amidase I; Provisional; Region: PRK10319 481805004011 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 481805004012 active site 481805004013 metal binding site [ion binding]; metal-binding site 481805004014 putative acetyltransferase; Provisional; Region: PRK03624 481805004015 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481805004016 Coenzyme A binding pocket [chemical binding]; other site 481805004017 Protein of unknown function (DUF2919); Region: DUF2919; pfam11143 481805004018 RpoE-regulated lipoprotein; Provisional; Region: PRK10718 481805004019 Protein of unknown function (DUF1131); Region: DUF1131; pfam06572 481805004020 Dyp-type peroxidase family; Region: Dyp_perox; pfam04261 481805004021 putative periplasmic esterase; Provisional; Region: PRK03642 481805004022 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 481805004023 PTS system N-acetylmuramic acid transporter subunits EIIBC; Reviewed; Region: murP; PRK09586 481805004024 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 481805004025 active site turn [active] 481805004026 phosphorylation site [posttranslational modification] 481805004027 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 481805004028 N-acetylmuramic acid-6-phosphate etherase; Reviewed; Region: murQ; PRK05441 481805004029 N-acetylmuramic acid 6-phosphate etherase. Members of this family contain the SIS (Sugar ISomerase) domain. The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. The bacterial cell wall sugar N-acetylmuramic acid...; Region: SIS_Etherase; cd05007 481805004030 putative active site [active] 481805004031 transcriptional regulator MurR; Provisional; Region: PRK15482 481805004032 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 481805004033 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 481805004034 putative active site [active] 481805004035 short chain dehydrogenase; Provisional; Region: PRK08226 481805004036 human DHRS6-like, classical (c) SDRs; Region: DHRS6_like_SDR_c; cd05368 481805004037 NAD binding site [chemical binding]; other site 481805004038 homotetramer interface [polypeptide binding]; other site 481805004039 homodimer interface [polypeptide binding]; other site 481805004040 active site 481805004041 thiosulfate transporter subunit; Provisional; Region: PRK10852 481805004042 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 481805004043 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 481805004044 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805004045 dimer interface [polypeptide binding]; other site 481805004046 conserved gate region; other site 481805004047 putative PBP binding loops; other site 481805004048 ABC-ATPase subunit interface; other site 481805004049 sulfate transport protein; Provisional; Region: cysT; CHL00187 481805004050 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805004051 dimer interface [polypeptide binding]; other site 481805004052 conserved gate region; other site 481805004053 putative PBP binding loops; other site 481805004054 ABC-ATPase subunit interface; other site 481805004055 sulfate/thiosulfate transporter subunit; Provisional; Region: PRK10851 481805004056 ATP-binding cassette domain of the sulfate transporter; Region: ABC_CysA_sulfate_importer; cd03296 481805004057 Walker A/P-loop; other site 481805004058 ATP binding site [chemical binding]; other site 481805004059 Q-loop/lid; other site 481805004060 ABC transporter signature motif; other site 481805004061 Walker B; other site 481805004062 D-loop; other site 481805004063 H-loop/switch region; other site 481805004064 TOBE-like domain; Region: TOBE_3; pfam12857 481805004065 cysteine synthase B; Region: cysM; TIGR01138 481805004066 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 481805004067 dimer interface [polypeptide binding]; other site 481805004068 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805004069 catalytic residue [active] 481805004070 hypothetical protein; Provisional; Region: PRK10318 481805004071 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 481805004072 dimer interface [polypeptide binding]; other site 481805004073 pyridoxamine kinase; Validated; Region: PRK05756 481805004074 pyridoxal binding site [chemical binding]; other site 481805004075 ATP binding site [chemical binding]; other site 481805004076 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 481805004077 HPr interaction site; other site 481805004078 glycerol kinase (GK) interaction site [polypeptide binding]; other site 481805004079 active site 481805004080 phosphorylation site [posttranslational modification] 481805004081 phosphoenolpyruvate-protein phosphotransferase; Provisional; Region: PRK11177 481805004082 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 481805004083 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 481805004084 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 481805004085 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 481805004086 dimerization domain swap beta strand [polypeptide binding]; other site 481805004087 regulatory protein interface [polypeptide binding]; other site 481805004088 active site 481805004089 regulatory phosphorylation site [posttranslational modification]; other site 481805004090 Cysteine synthase [Amino acid transport and metabolism]; Region: CysK; COG0031 481805004091 CBS_like: This subgroup includes Cystathionine beta-synthase (CBS) and Cysteine synthase. CBS is a unique heme-containing enzyme that catalyzes a pyridoxal 5'-phosphate (PLP)-dependent condensation of serine and homocysteine to give cystathionine; Region: CBS_like; cd01561 481805004092 dimer interface [polypeptide binding]; other site 481805004093 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805004094 catalytic residue [active] 481805004095 putative sulfate transport protein CysZ; Validated; Region: PRK04949 481805004096 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cl12038 481805004097 cell division protein ZipA; Provisional; Region: PRK03427 481805004098 ZipA C-terminal domain. ZipA, a membrane-anchored protein, is one of at least nine essential gene products necessary for assembly of the septal ring which mediates cell division in E.coli. ZipA and FtsA directly bind FtsZ, a homolog of eukaryotic...; Region: ZipA; cd00231 481805004099 FtsZ protein binding site [polypeptide binding]; other site 481805004100 NAD-dependent DNA ligase LigA; Validated; Region: ligA; PRK07956 481805004101 NAD+ dependent DNA ligase adenylation domain. DNA ligases catalyze the crucial step of joining the breaks in duplex DNA during DNA replication, repair and recombination, utilizing either ATP or NAD(+) as a cofactor, but using the same basic reaction...; Region: LIGANc; cd00114 481805004102 nucleotide binding pocket [chemical binding]; other site 481805004103 K-X-D-G motif; other site 481805004104 catalytic site [active] 481805004105 NAD-dependent DNA ligase OB-fold domain; Region: DNA_ligase_OB; pfam03120 481805004106 NAD-dependent DNA ligase C4 zinc finger domain; Region: DNA_ligase_ZBD; pfam03119 481805004107 Breast Cancer Suppressor Protein (BRCA1), carboxy-terminal domain. The BRCT domain is found within many DNA damage repair and cell cycle checkpoint proteins. The unique diversity of this domain superfamily allows BRCT modules to interact forming homo...; Region: BRCT; cd00027 481805004108 Dimer interface [polypeptide binding]; other site 481805004109 BRCT sequence motif; other site 481805004110 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3530 481805004111 Predicted Na+-dependent transporter [General function prediction only]; Region: COG0385 481805004112 SBF-like CPA transporter family (DUF4137); Region: DUF4137; pfam13593 481805004113 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481805004114 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805004115 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 481805004116 putative dimerization interface [polypeptide binding]; other site 481805004117 glutamyl-tRNA synthetase; Reviewed; Region: gltX; PRK01406 481805004118 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 481805004119 active site 481805004120 HIGH motif; other site 481805004121 catalytic core domain of discriminating glutamyl-tRNA synthetase; Region: GluRS_core; cd00808 481805004122 active site 481805004123 KMSKS motif; other site 481805004124 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805004125 salt bridge; other site 481805004126 non-specific DNA binding site [nucleotide binding]; other site 481805004127 sequence-specific DNA binding site [nucleotide binding]; other site 481805004128 Putative transcription regulator (DUF1323); Region: DUF1323; pfam07037 481805004129 MASE1; Region: MASE1; pfam05231 481805004130 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481805004131 diguanylate cyclase; Region: GGDEF; smart00267 481805004132 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805004133 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 481805004134 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 481805004135 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 481805004136 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 481805004137 Nucleoside recognition; Region: Gate; pfam07670 481805004138 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 481805004139 manganese transport protein MntH; Reviewed; Region: PRK00701 481805004140 Natural resistance-associated macrophage protein; Region: Nramp; pfam01566 481805004141 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 481805004142 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 481805004143 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 481805004144 Cl- selectivity filter; other site 481805004145 Cl- binding residues [ion binding]; other site 481805004146 pore gating glutamate residue; other site 481805004147 dimer interface [polypeptide binding]; other site 481805004148 glucokinase, proteobacterial type; Region: glk; TIGR00749 481805004149 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481805004150 nucleotide binding site [chemical binding]; other site 481805004151 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 481805004152 active site 481805004153 P-loop; other site 481805004154 phosphorylation site [posttranslational modification] 481805004155 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 481805004156 aminopeptidase; Provisional; Region: PRK09795 481805004157 Creatinase/Prolidase N-terminal domain; Region: Creatinase_N; pfam01321 481805004158 Similar to Prolidase and Aminopeptidase P. The members of this subfamily presumably catalyse hydrolysis of Xaa-Pro dipeptides and/or release of any N-terminal amino acid, including proline, that is linked with proline; Region: APP-like; cd01092 481805004159 active site 481805004160 exoaminopeptidase; Provisional; Region: PRK09961 481805004161 M42 Peptidases, also known as glutamyl aminopeptidase family; Region: M42; cd05638 481805004162 oligomer interface [polypeptide binding]; other site 481805004163 active site 481805004164 metal binding site [ion binding]; metal-binding site 481805004165 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 481805004166 dimerization domain swap beta strand [polypeptide binding]; other site 481805004167 regulatory protein interface [polypeptide binding]; other site 481805004168 active site 481805004169 regulatory phosphorylation site [posttranslational modification]; other site 481805004170 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 481805004171 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 481805004172 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 481805004173 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 481805004174 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481805004175 active site 481805004176 phosphorylation site [posttranslational modification] 481805004177 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481805004178 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805004179 Response regulator of the LytR/AlgR family [Transcription / Signal transduction mechanisms]; Region: LytT; COG3279 481805004180 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805004181 active site 481805004182 phosphorylation site [posttranslational modification] 481805004183 intermolecular recognition site; other site 481805004184 dimerization interface [polypeptide binding]; other site 481805004185 LytTr DNA-binding domain; Region: LytTR; pfam04397 481805004186 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 481805004187 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 481805004188 GAF domain; Region: GAF; pfam01590 481805004189 Histidine kinase; Region: His_kinase; pfam06580 481805004190 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805004191 ATP binding site [chemical binding]; other site 481805004192 Mg2+ binding site [ion binding]; other site 481805004193 G-X-G motif; other site 481805004194 aminotransferase; Validated; Region: PRK08175 481805004195 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481805004196 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805004197 homodimer interface [polypeptide binding]; other site 481805004198 catalytic residue [active] 481805004199 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 481805004200 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 481805004201 putative acyl-acceptor binding pocket; other site 481805004202 Protein of unknown function (DUF2545); Region: DUF2545; pfam10810 481805004203 hypothetical protein; Provisional; Region: PRK10316 481805004204 YfdX protein; Region: YfdX; pfam10938 481805004205 formyl-coenzyme A transferase; Provisional; Region: PRK05398 481805004206 CoA-transferase family III; Region: CoA_transf_3; pfam02515 481805004207 putative oxalyl-CoA decarboxylase; Validated; Region: PRK09259 481805004208 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 481805004209 PYR/PP interface [polypeptide binding]; other site 481805004210 dimer interface [polypeptide binding]; other site 481805004211 TPP binding site [chemical binding]; other site 481805004212 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 481805004213 Thiamine pyrophosphate (TPP) family, BZL_OCoD_HPCL subfamily, TPP-binding module; composed of proteins similar to benzaldehyde lyase (BZL), oxalyl-CoA decarboxylase (OCoD) and 2-hydroxyphytanoyl-CoA lyase (2-HPCL). Pseudomonas fluorescens biovar I BZL...; Region: TPP_BZL_OCoD_HPCL; cd02004 481805004214 TPP-binding site; other site 481805004215 dimer interface [polypeptide binding]; other site 481805004216 putative transporter YfdV; Provisional; Region: PRK09903 481805004217 putative CoA-transferase; Provisional; Region: PRK11430 481805004218 CoA-transferase family III; Region: CoA_transf_3; pfam02515 481805004219 hybrid sensory histidine kinase in two-component regulatory system with EvgA; Provisional; Region: PRK09959 481805004220 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805004221 substrate binding pocket [chemical binding]; other site 481805004222 membrane-bound complex binding site; other site 481805004223 hinge residues; other site 481805004224 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805004225 substrate binding pocket [chemical binding]; other site 481805004226 membrane-bound complex binding site; other site 481805004227 hinge residues; other site 481805004228 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805004229 dimer interface [polypeptide binding]; other site 481805004230 phosphorylation site [posttranslational modification] 481805004231 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805004232 ATP binding site [chemical binding]; other site 481805004233 Mg2+ binding site [ion binding]; other site 481805004234 G-X-G motif; other site 481805004235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805004236 active site 481805004237 phosphorylation site [posttranslational modification] 481805004238 intermolecular recognition site; other site 481805004239 dimerization interface [polypeptide binding]; other site 481805004240 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 481805004241 putative binding surface; other site 481805004242 active site 481805004243 DNA-binding transcriptional activator EvgA; Provisional; Region: PRK09958 481805004244 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805004245 active site 481805004246 phosphorylation site [posttranslational modification] 481805004247 intermolecular recognition site; other site 481805004248 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805004249 DNA binding residues [nucleotide binding] 481805004250 dimerization interface [polypeptide binding]; other site 481805004251 efflux pump membrane protein (multidrug resistance protein A); Region: 8a0101; TIGR00998 481805004252 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481805004253 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805004254 drug resistance transporter, EmrB/QacA subfamily; Region: efflux_EmrB; TIGR00711 481805004255 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805004256 putative substrate translocation pore; other site 481805004257 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805004258 D-Serine dehydratase is a pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of L- or D-serine to pyruvate and ammonia. D-serine dehydratase serves as a detoxifying enzyme in most E. coli strains where D-serine is a competitive...; Region: D-Ser-dehyd; cd06447 481805004259 Pyridoxal-phosphate dependent enzyme; Region: PALP; pfam00291 481805004260 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 481805004261 catalytic residue [active] 481805004262 permease DsdX; Provisional; Region: PRK09921 481805004263 gluconate transporter; Region: gntP; TIGR00791 481805004264 DNA-binding transcriptional regulator DsdC; Provisional; Region: PRK10086 481805004265 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805004266 The C-terminal substrate domain of LysR-type GcdR, TrPI, HvR and beta-lactamase regulators, and that of other closely related homologs; contains the type 2 periplasmic binding fold; Region: PBP2_GcdR_TrpI_HvrB_AmpR_like; cd08432 481805004267 dimerization interface [polypeptide binding]; other site 481805004268 substrate binding pocket [chemical binding]; other site 481805004269 Formate/nitrite family of transporters [Inorganic ion transport and metabolism]; Region: FocA; COG2116 481805004270 ABC transporter outer membrane lipoprotein; Provisional; Region: PRK15091 481805004271 long-chain fatty acid outer membrane transporter; Provisional; Region: PRK10716 481805004272 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3691 481805004273 3-ketoacyl-CoA thiolase; Reviewed; Region: fadI; PRK08963 481805004274 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 481805004275 dimer interface [polypeptide binding]; other site 481805004276 active site 481805004277 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadJ; PRK11154 481805004278 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 481805004279 substrate binding site [chemical binding]; other site 481805004280 oxyanion hole (OAH) forming residues; other site 481805004281 trimer interface [polypeptide binding]; other site 481805004282 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 481805004283 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 481805004284 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 481805004285 catalytic core [active] 481805004286 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 481805004287 putative fimbrial outer membrane usher protein StfC; Provisional; Region: PRK15284 481805004288 PapC N-terminal domain; Region: PapC_N; pfam13954 481805004289 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 481805004290 PapC C-terminal domain; Region: PapC_C; pfam13953 481805004291 putative fimbrial chaperone protein StfD; Provisional; Region: PRK15285 481805004292 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 481805004293 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 481805004294 Fimbrial protein; Region: Fimbrial; cl01416 481805004295 Fimbrial protein; Region: Fimbrial; cl01416 481805004296 Fimbrial protein; Region: Fimbrial; cl01416 481805004297 Protein of unknown function (DUF2544); Region: DUF2544; pfam11245 481805004298 hypothetical protein; Provisional; Region: PRK04946 481805004299 Smr domain; Region: Smr; pfam01713 481805004300 HemK family putative methylases; Region: hemK_fam; TIGR00536 481805004301 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805004302 S-adenosylmethionine binding site [chemical binding]; other site 481805004303 Chorismate synthase [Amino acid transport and metabolism]; Region: AroC; COG0082 481805004304 Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway; Region: Chorismate_synthase; cd07304 481805004305 Tetramer interface [polypeptide binding]; other site 481805004306 active site 481805004307 FMN-binding site [chemical binding]; other site 481805004308 Murein endopeptidase [Cell envelope biogenesis, outer membrane]; Region: MepA; COG3770 481805004309 penicillin-insensitive murein endopeptidase; Reviewed; Region: mepA; PRK09429 481805004310 hypothetical protein; Provisional; Region: PRK10621 481805004311 Predicted permeases [General function prediction only]; Region: COG0730 481805004312 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3101 481805004313 YfcL protein; Region: YfcL; pfam08891 481805004314 Uncharacterized conserved protein [Function unknown]; Region: COG4121 481805004315 bifunctional tRNA (mnm(5)s(2)U34)-methyltransferase/FAD-dependent cmnm(5)s(2)U34 oxidoreductase; Reviewed; Region: mnmC; PRK01747 481805004316 3-oxoacyl-(acyl carrier protein) synthase I; Reviewed; Region: PRK07967 481805004317 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 481805004318 dimer interface [polypeptide binding]; other site 481805004319 active site 481805004320 putative transporter; Provisional; Region: PRK12382 481805004321 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805004322 putative substrate translocation pore; other site 481805004323 flagella biosynthesis regulator; Provisional; Region: flk; PRK10715 481805004324 erythronate-4-phosphate dehydrogenase PdxB; Provisional; Region: PRK15438 481805004325 D-Erythronate-4-Phosphate Dehydrogenase NAD-binding and catalytic domains; Region: ErythrP_dh; cd12158 481805004326 ligand binding site [chemical binding]; other site 481805004327 NAD binding site [chemical binding]; other site 481805004328 catalytic site [active] 481805004329 homodimer interface [polypeptide binding]; other site 481805004330 putative semialdehyde dehydrogenase; Provisional; Region: PRK08040 481805004331 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 481805004332 tRNA pseudouridine synthase A; Validated; Region: truA; PRK00021 481805004333 Eukaryotic and bacterial pseudouridine synthases similar to E. coli TruA; Region: PseudoU_synth_EcTruA; cd02570 481805004334 dimerization interface 3.5A [polypeptide binding]; other site 481805004335 active site 481805004336 hypothetical protein; Provisional; Region: PRK10847 481805004337 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 481805004338 acetyl-CoA carboxylase subunit beta; Validated; Region: PRK05654 481805004339 malonate decarboxylase subunit beta; Reviewed; Region: PRK07189; cl17682 481805004340 bifunctional folylpolyglutamate synthase/ dihydrofolate synthase; Provisional; Region: PRK10846 481805004341 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 481805004342 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 481805004343 cell division protein DedD; Provisional; Region: PRK11633 481805004344 Sporulation related domain; Region: SPOR; pfam05036 481805004345 colicin V production protein; Provisional; Region: PRK10845 481805004346 Uncharacterized membrane protein, required for colicin V production [General function prediction only]; Region: CvpA; COG1286 481805004347 amidophosphoribosyltransferase; Provisional; Region: PRK09246 481805004348 Glutamine amidotransferases class-II (GN-AT)_GPAT- type. This domain is found at the N-terminus of glutamine phosphoribosylpyrophosphate (Prpp) amidotransferase (GPATase) . The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the...; Region: GPATase_N; cd00715 481805004349 active site 481805004350 tetramer interface [polypeptide binding]; other site 481805004351 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481805004352 active site 481805004353 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Provisional; Region: PRK06029 481805004354 Flavoprotein; Region: Flavoprotein; pfam02441 481805004355 ABC transporter lysine/arginine/ornithine binding periplasmic protein; Provisional; Region: PRK15010 481805004356 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805004357 substrate binding pocket [chemical binding]; other site 481805004358 membrane-bound complex binding site; other site 481805004359 hinge residues; other site 481805004360 histidine ABC transporter substrate-binding protein HisJ; Provisional; Region: PRK15437 481805004361 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805004362 substrate binding pocket [chemical binding]; other site 481805004363 membrane-bound complex binding site; other site 481805004364 hinge residues; other site 481805004365 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 481805004366 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805004367 dimer interface [polypeptide binding]; other site 481805004368 conserved gate region; other site 481805004369 putative PBP binding loops; other site 481805004370 ABC-ATPase subunit interface; other site 481805004371 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805004372 dimer interface [polypeptide binding]; other site 481805004373 conserved gate region; other site 481805004374 putative PBP binding loops; other site 481805004375 ABC-ATPase subunit interface; other site 481805004376 histidine/lysine/arginine/ornithine transporter subunit; Provisional; Region: PRK10619 481805004377 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 481805004378 Walker A/P-loop; other site 481805004379 ATP binding site [chemical binding]; other site 481805004380 Q-loop/lid; other site 481805004381 ABC transporter signature motif; other site 481805004382 Walker B; other site 481805004383 D-loop; other site 481805004384 H-loop/switch region; other site 481805004385 putative transposase; Provisional; Region: PRK09857 481805004386 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 481805004387 atypical (a) SDRs, subgroup 8; Region: SDR_a8; cd05242 481805004388 Predicted nucleoside-diphosphate sugar epimerase [General function prediction only]; Region: COG1090 481805004389 putative NAD(P) binding site [chemical binding]; other site 481805004390 putative active site [active] 481805004391 Dihydroneopterin aldolase (DHNA) and 7,8-dihydroneopterin triphosphate epimerase domain (DHNTPE); these enzymes have been designated folB and folX, respectively. Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and...; Region: DHNA_DHNTPE; cd00534 481805004392 homooctamer interface [polypeptide binding]; other site 481805004393 active site 481805004394 GSH-dependent disulfide bond oxidoreductase; Provisional; Region: PRK13972 481805004395 GST_N family, Ure2p-like subfamily; composed of the Saccharomyces cerevisiae Ure2p and related GSTs. Ure2p is a regulator for nitrogen catabolism in yeast. It represses the expression of several gene products involved in the use of poor nitrogen sources...; Region: GST_N_Ure2p_like; cd03048 481805004396 C-terminal domain interface [polypeptide binding]; other site 481805004397 GSH binding site (G-site) [chemical binding]; other site 481805004398 dimer interface [polypeptide binding]; other site 481805004399 C-terminal, alpha helical domain of Escherichia coli YfcG Glutathione S-transferases and related uncharacterized proteins; Region: GST_C_YfcG_like; cd10291 481805004400 N-terminal domain interface [polypeptide binding]; other site 481805004401 putative dimer interface [polypeptide binding]; other site 481805004402 active site 481805004403 glutathione S-transferase; Provisional; Region: PRK15113 481805004404 Glutathione S-transferase (GST) family, N-terminal domain; a large, diverse group of cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic...; Region: GST_N_family; cd00570 481805004405 C-terminal domain interface [polypeptide binding]; other site 481805004406 GSH binding site (G-site) [chemical binding]; other site 481805004407 dimer interface [polypeptide binding]; other site 481805004408 C-terminal, alpha helical domain of an unknown subfamily 4 of Glutathione S-transferases; Region: GST_C_4; cd03195 481805004409 N-terminal domain interface [polypeptide binding]; other site 481805004410 putative dimer interface [polypeptide binding]; other site 481805004411 putative substrate binding pocket (H-site) [chemical binding]; other site 481805004412 Escherichia coli YfcE and related proteins, metallophosphatase domain; Region: MPP_YfcE; cd00841 481805004413 active site 481805004414 metal binding site [ion binding]; metal-binding site 481805004415 homotetramer interface [polypeptide binding]; other site 481805004416 NUDIX hydrolase YfcD; Provisional; Region: PRK15393 481805004417 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_38; cd04697 481805004418 nudix motif; other site 481805004419 hypothetical protein; Provisional; Region: PRK11588 481805004420 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 481805004421 phosphate acetyltransferase; Reviewed; Region: PRK05632 481805004422 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 481805004423 DRTGG domain; Region: DRTGG; pfam07085 481805004424 phosphate acetyltransferase; Region: pta; TIGR00651 481805004425 propionate/acetate kinase; Provisional; Region: PRK12379 481805004426 acetate kinase A/propionate kinase 2; Reviewed; Region: PRK00180 481805004427 hypothetical protein; Provisional; Region: PRK01816 481805004428 hypothetical protein; Validated; Region: PRK05445 481805004429 putative phosphatase; Provisional; Region: PRK11587 481805004430 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805004431 motif II; other site 481805004432 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 481805004433 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 481805004434 TrkA-C domain; Region: TrkA_C; pfam02080 481805004435 TrkA-C domain; Region: TrkA_C; pfam02080 481805004436 Permease SLC13 (solute carrier 13). The sodium/dicarboxylate cotransporter NaDC-1 has been shown to translocate Krebs cycle intermediates such as succinate, citrate, and alpha-ketoglutarate across plasma membranes rabbit, human, and rat kidney. It is...; Region: SLC13_permease; cd01115 481805004437 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481805004438 Zn2+ binding site [ion binding]; other site 481805004439 Mg2+ binding site [ion binding]; other site 481805004440 aminotransferase AlaT; Validated; Region: PRK09265 481805004441 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481805004442 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805004443 homodimer interface [polypeptide binding]; other site 481805004444 catalytic residue [active] 481805004445 DNA-binding transcriptional repressor LrhA; Provisional; Region: PRK15092 481805004446 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805004447 The C-terminal substrate domain of LysR-like regulator LrhA (LysR homologue A) and that of closely related homologs, contains the type 2 periplasmic binding fold; Region: PBP2_LrhA_like; cd08439 481805004448 putative dimerization interface [polypeptide binding]; other site 481805004449 NADH:ubiquinone oxidoreductase subunit A; Validated; Region: PRK06602 481805004450 NADH:ubiquinone oxidoreductase 20 kD subunit and related Fe-S oxidoreductases [Energy production and conversion]; Region: NuoB; COG0377 481805004451 bifunctional NADH:ubiquinone oxidoreductase subunit C/D; Provisional; Region: PRK11742 481805004452 NADH (or F420H2) dehydrogenase, subunit C; Region: NuoC_fam; TIGR01961 481805004453 NADH dehydrogenase subunit D; Validated; Region: PRK06075 481805004454 NADH dehydrogenase subunit E; Validated; Region: PRK07539 481805004455 TRX-like [2Fe-2S] Ferredoxin (Fd) family, NADH:ubiquinone oxidoreductase (Nuo) subunit E subfamily; Nuo, also called respiratory chain Complex 1, is the entry point for electrons into the respiratory chains of bacteria and the mitochondria of eukaryotes; Region: TRX_Fd_NuoE; cd03064 481805004456 putative dimer interface [polypeptide binding]; other site 481805004457 [2Fe-2S] cluster binding site [ion binding]; other site 481805004458 NADH dehydrogenase I subunit F; Provisional; Region: PRK11278 481805004459 SLBB domain; Region: SLBB; pfam10531 481805004460 NADH-ubiquinone oxidoreductase-F iron-sulfur binding region; Region: NADH_4Fe-4S; pfam10589 481805004461 NADH dehydrogenase/NADH:ubiquinone oxidoreductase 75 kD subunit (chain G) [Energy production and conversion]; Region: NuoG; COG1034 481805004462 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 481805004463 catalytic loop [active] 481805004464 iron binding site [ion binding]; other site 481805004465 NADH-ubiquinone oxidoreductase-G iron-sulfur binding region; Region: NADH-G_4Fe-4S_3; pfam10588 481805004466 MopB_NDH-1_NuoG2-N7: The second domain of the NuoG subunit (with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex in the respiratory...; Region: MopB_NDH-1_NuoG2-N7; cd02771 481805004467 [4Fe-4S] binding site [ion binding]; other site 481805004468 MopB_CT_NDH-1_NuoG2-N7: C-terminal region of the NuoG-like subunit (of the variant with a [4Fe-4S] cluster, N7) of the NADH-quinone oxidoreductase/NADH dehydrogenase-1 (NDH-1) found in various bacteria. The NDH-1 is the first energy-transducting complex...; Region: MopB_CT_NDH-1_NuoG2-N7; cd02788 481805004469 NADH:ubiquinone oxidoreductase subunit H; Provisional; Region: PRK06076 481805004470 NADH dehydrogenase subunit I; Provisional; Region: PRK05888 481805004471 4Fe-4S binding domain; Region: Fer4; pfam00037 481805004472 4Fe-4S binding domain; Region: Fer4; pfam00037 481805004473 NADH:ubiquinone oxidoreductase subunit J; Provisional; Region: PRK06638 481805004474 NADH:ubiquinone oxidoreductase subunit K; Validated; Region: PRK05715 481805004475 NADH:ubiquinone oxidoreductase subunit L; Reviewed; Region: PRK06590 481805004476 NADH-Ubiquinone oxidoreductase (complex I), chain 5 N-terminus; Region: Oxidored_q1_N; pfam00662 481805004477 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 481805004478 NADH:ubiquinone oxidoreductase subunit M; Reviewed; Region: PRK05846 481805004479 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 481805004480 NADH:ubiquinone oxidoreductase subunit N; Provisional; Region: PRK05777 481805004481 NADH-Ubiquinone/plastoquinone (complex I), various chains; Region: Oxidored_q1; pfam00361 481805004482 Domain of unknown function (DUF1877); Region: DUF1877; pfam08974 481805004483 ribonuclease BN; Region: true_RNase_BN; TIGR02649 481805004484 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481805004485 Coenzyme A binding pocket [chemical binding]; other site 481805004486 hypothetical protein; Provisional; Region: PRK10404 481805004487 menaquinone-specific isochorismate synthase; Provisional; Region: PRK15012 481805004488 isochorismate synthases; Region: isochor_syn; TIGR00543 481805004489 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1- carboxylate synthase; Validated; Region: PRK07449 481805004490 Pyrimidine (PYR) binding domain of 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexadiene-1- carboxylate synthase (MenD) and related proteins; Region: TPP_PYR_MenD; cd07037 481805004491 dimer interface [polypeptide binding]; other site 481805004492 tetramer interface [polypeptide binding]; other site 481805004493 PYR/PP interface [polypeptide binding]; other site 481805004494 TPP binding site [chemical binding]; other site 481805004495 Thiamine pyrophosphate (TPP) family, SHCHC synthase subfamily, TPP-binding module; composed of proteins similar to Escherichia coli 2-succinyl-6-hydroxyl-2,4-cyclohexadiene-1-carboxylic acid (SHCHC) synthase (also called MenD). SHCHC synthase plays a key...; Region: TPP_SHCHC_synthase; cd02009 481805004496 TPP-binding site; other site 481805004497 2-succinyl-6-hydroxy-2, 4-cyclohexadiene-1-carboxylate synthase; Provisional; Region: PRK11126 481805004498 Lipase. Lipases are esterases that can hydrolyze long-chain acyl-triglycerides into di- and monoglycerides, glycerol, and free fatty acids at a water/lipid interface. A typical feature of lipases is "interfacial activation", the process of...; Region: Lipase; cl14883 481805004499 nucleophilic elbow; other site 481805004500 catalytic triad; other site 481805004501 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 481805004502 Enoyl-CoA hydratase/isomerase family; Region: ECH; pfam00378 481805004503 substrate binding site [chemical binding]; other site 481805004504 oxyanion hole (OAH) forming residues; other site 481805004505 trimer interface [polypeptide binding]; other site 481805004506 O-succinylbenzoate synthase; Provisional; Region: PRK05105 481805004507 o-Succinylbenzoate synthase (OSBS) catalyzes the conversion of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate (o-succinylbenzoate or OSB), a reaction in the menaquinone biosynthetic pathway; Region: OSBS; cd03320 481805004508 active site 481805004509 O-succinylbenzoic acid--CoA ligase; Provisional; Region: PRK09029 481805004510 O-succinylbenzoate-CoA ligase (also known as O-succinylbenzoate-CoA synthase, OSB-CoA synthetase, or MenE); Region: OSB_CoA_lg; cd05912 481805004511 acyl-activating enzyme (AAE) consensus motif; other site 481805004512 putative AMP binding site [chemical binding]; other site 481805004513 putative active site [active] 481805004514 putative CoA binding site [chemical binding]; other site 481805004515 signal transduction protein PmrD; Provisional; Region: PRK15450 481805004516 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF; Provisional; Region: PRK02971 481805004517 4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE; Provisional; Region: PRK15051 481805004518 4-amino-4-deoxy-L-arabinose transferase; Provisional; Region: arnT; PRK13279 481805004519 4-amino-4-deoxy-L-arabinose transferase and related glycosyltransferases of PMT family [Cell envelope biogenesis, outer membrane]; Region: ArnT; COG1807 481805004520 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD; Provisional; Region: PRK15394 481805004521 Catalytic domain of Escherichia coli 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD and other bacterial homologs; Region: CE4_ArnD; cd10939 481805004522 putative active site [active] 481805004523 putative catalytic site [active] 481805004524 putative Zn binding site [ion binding]; other site 481805004525 bifunctional UDP-glucuronic acid decarboxylase/UDP-4-amino-4-deoxy-L-arabinose formyltransferase; Validated; Region: PRK08125 481805004526 ArnA, N-terminal formyltransferase domain; Region: FMT_core_ArnA_N; cd08644 481805004527 substrate binding site [chemical binding]; other site 481805004528 cosubstrate binding site; other site 481805004529 catalytic site [active] 481805004530 C-terminal subdomain of the formyltransferase domain on ArnA, which modifies lipid A with 4-amino-4-deoxy-l-arabinose; Region: Arna_FMT_C; cd08702 481805004531 active site 481805004532 hexamer interface [polypeptide binding]; other site 481805004533 Arna decarboxylase_like, extended (e) SDRs; Region: Arna_like_SDR_e; cd05257 481805004534 NAD binding site [chemical binding]; other site 481805004535 substrate binding site [chemical binding]; other site 481805004536 active site 481805004537 undecaprenyl phosphate 4-deoxy-4-formamido-L-arabinose transferase; Provisional; Region: PRK10714 481805004538 Bacterial DPM1_like enzymes are related to eukaryotic DPM1; Region: DPM1_like_bac; cd04187 481805004539 Ligand binding site; other site 481805004540 Putative Catalytic site; other site 481805004541 DXD motif; other site 481805004542 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 481805004543 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 481805004544 inhibitor-cofactor binding pocket; inhibition site 481805004545 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805004546 catalytic residue [active] 481805004547 Histidine phosphatase domain found in a functionally diverse set of proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP; cd07040 481805004548 catalytic core [active] 481805004549 nucleoside triphosphatase NudI; Provisional; Region: PRK15472 481805004550 YfaZ precursor; Region: YfaZ; pfam07437 481805004551 outer membrane protein; Region: OMP_w_GlyGly; TIGR04219 481805004552 hypothetical protein; Provisional; Region: PRK03673 481805004553 Competence-damaged protein. CinA is the first gene in the competence- inducible (cin) operon and is thought to be specifically required at some stage in the process of transformation. This domain is closely related to a domain, found in a variety of...; Region: cinA; cd00885 481805004554 putative MPT binding site; other site 481805004555 Competence-damaged protein; Region: CinA; cl00666 481805004556 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 481805004557 Transcriptional regulator [Transcription]; Region: IclR; COG1414 481805004558 Bacterial transcriptional regulator; Region: IclR; pfam01614 481805004559 L-rhamnonate dehydratase; Provisional; Region: PRK15440 481805004560 Mandelate racemase (MR)-like subfamily of the enolase superfamily, subgroup 2. Enzymes of this subgroup share three conserved carboxylate ligands for the essential divalent metal ion (usually Mg2+), two aspartates and a glutamate, and conserved catalytic...; Region: MR_like_2; cd03327 481805004561 putative active site pocket [active] 481805004562 putative metal binding site [ion binding]; other site 481805004563 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 481805004564 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805004565 putative substrate translocation pore; other site 481805004566 2-keto-3-deoxy-L-rhamnonate aldolase; Provisional; Region: PRK10128 481805004567 hypothetical protein; Provisional; Region: PRK09956 481805004568 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 481805004569 glycerol-3-phosphate dehydrogenase, anaerobic, C subunit; Region: glycerol3P_GlpC; TIGR03379 481805004570 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 481805004571 Cysteine-rich domain; Region: CCG; pfam02754 481805004572 Cysteine-rich domain; Region: CCG; pfam02754 481805004573 Anaerobic glycerol-3-phosphate dehydrogenase [Amino acid transport and metabolism]; Region: GlpB; COG3075 481805004574 anaerobic glycerol-3-phosphate dehydrogenase subunit B; Validated; Region: PRK05329 481805004575 sn-glycerol-3-phosphate dehydrogenase subunit A; Provisional; Region: glpA; PRK11101 481805004576 hydroxyglutarate oxidase; Provisional; Region: PRK11728 481805004577 BFD-like [2Fe-2S] binding domain; Region: Fer2_BFD; pfam04324 481805004578 sn-glycerol-3-phosphate transporter; Provisional; Region: glpT; PRK11273 481805004579 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805004580 putative substrate translocation pore; other site 481805004581 glycerophosphodiester phosphodiesterase; Provisional; Region: glpQ; PRK11143 481805004582 Glycerophosphodiester phosphodiesterase domain of Escherichia coli (GlpQ) and similar proteins; Region: GDPD_EcGlpQ_like; cd08600 481805004583 active site 481805004584 catalytic site [active] 481805004585 metal binding site [ion binding]; metal-binding site 481805004586 hypothetical protein; Provisional; Region: PRK09729 481805004587 hypothetical protein; Provisional; Region: PRK09902 481805004588 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 481805004589 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 481805004590 catalytic loop [active] 481805004591 iron binding site [ion binding]; other site 481805004592 Ribonucleotide Reductase, R2/beta subunit, ferritin-like diiron-binding domain; Region: RNRR2; cd01049 481805004593 dimer interface [polypeptide binding]; other site 481805004594 putative radical transfer pathway; other site 481805004595 diiron center [ion binding]; other site 481805004596 tyrosyl radical; other site 481805004597 ribonucleotide-diphosphate reductase subunit alpha; Validated; Region: PRK09103 481805004598 ATP cone domain; Region: ATP-cone; pfam03477 481805004599 Class I ribonucleotide reductase; Region: RNR_I; cd01679 481805004600 active site 481805004601 dimer interface [polypeptide binding]; other site 481805004602 catalytic residues [active] 481805004603 effector binding site; other site 481805004604 R2 peptide binding site; other site 481805004605 adhesin; Provisional; Region: PRK09752 481805004606 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 481805004607 Autotransporter beta-domain; Region: Autotransporter; pfam03797 481805004608 bifunctional 3-demethylubiquinone-9 3-methyltransferase/ 2-octaprenyl-6-hydroxy phenol methylase; Provisional; Region: PRK05134 481805004609 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805004610 S-adenosylmethionine binding site [chemical binding]; other site 481805004611 DNA gyrase subunit A; Validated; Region: PRK05560 481805004612 DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A subunit, GyrA),mammalian DNA toposiomerases II. DNA topoisomerases are essential enzymes that regulate the conformational changes...; Region: TOP4c; cd00187 481805004613 CAP-like domain; other site 481805004614 active site 481805004615 primary dimer interface [polypeptide binding]; other site 481805004616 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481805004617 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481805004618 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481805004619 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481805004620 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481805004621 DNA gyrase C-terminal domain, beta-propeller; Region: DNA_gyraseA_C; pfam03989 481805004622 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4685 481805004623 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3234 481805004624 Large extracellular alpha-helical protein [General function prediction only]; Region: COG2373 481805004625 MG2 domain; Region: A2M_N; pfam01835 481805004626 polycystic kidney disease I (PKD) domain; similar to other cell-surface modules, with an IG-like fold; domain probably functions as a ligand binding site in protein-protein or protein-carbohydrate interactions; a single instance of the repeat is...; Region: PKD; cl17457 481805004627 Alpha-2-macroglobulin family; Region: A2M; pfam00207 481805004628 This group contains class II terpene cyclases, protein prenyltransferases beta subunit, two broadly specific proteinase inhibitors alpha2-macroglobulin (alpha (2)-M) and pregnancy zone protein (PZP) and, the C3 C4 and C5 components of vertebrate...; Region: ISOPREN_C2_like; cl08267 481805004629 Predicted secreted protein [Function unknown]; Region: COG5445 481805004630 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 481805004631 Predicted secreted protein [Function unknown]; Region: COG5445 481805004632 Stage II sporulation protein; Region: SpoIID; pfam08486 481805004633 Predicted secreted protein (DUF2300); Region: DUF2300; pfam10062 481805004634 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4676 481805004635 Uncharacterized protein conserved in bacteria (DUF2135); Region: DUF2135; pfam09906 481805004636 putative acyltransferase; Provisional; Region: PRK05790 481805004637 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 481805004638 dimer interface [polypeptide binding]; other site 481805004639 active site 481805004640 Short chain fatty acid transporter; Region: SCFA_trans; pfam02667 481805004641 3-oxoacid CoA-transferase, B subunit; Region: pcaJ_scoB_fam; TIGR02428 481805004642 acetyl-CoA:acetoacetyl-CoA transferase subunit alpha; Provisional; Region: PRK09920 481805004643 acetoacetate metabolism regulatory protein AtoC; Provisional; Region: PRK11361 481805004644 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805004645 active site 481805004646 phosphorylation site [posttranslational modification] 481805004647 intermolecular recognition site; other site 481805004648 dimerization interface [polypeptide binding]; other site 481805004649 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805004650 Walker A motif; other site 481805004651 ATP binding site [chemical binding]; other site 481805004652 Walker B motif; other site 481805004653 arginine finger; other site 481805004654 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 481805004655 sensory histidine kinase AtoS; Provisional; Region: PRK11360 481805004656 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481805004657 putative active site [active] 481805004658 heme pocket [chemical binding]; other site 481805004659 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805004660 dimer interface [polypeptide binding]; other site 481805004661 phosphorylation site [posttranslational modification] 481805004662 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805004663 ATP binding site [chemical binding]; other site 481805004664 Mg2+ binding site [ion binding]; other site 481805004665 G-X-G motif; other site 481805004666 hybrid sensory kinase in two-component regulatory system with RcsB and YojN; Provisional; Region: PRK10841 481805004667 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805004668 dimer interface [polypeptide binding]; other site 481805004669 phosphorylation site [posttranslational modification] 481805004670 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805004671 ATP binding site [chemical binding]; other site 481805004672 Mg2+ binding site [ion binding]; other site 481805004673 G-X-G motif; other site 481805004674 RcsC Alpha-Beta-Loop (ABL); Region: RcsC; pfam09456 481805004675 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805004676 active site 481805004677 phosphorylation site [posttranslational modification] 481805004678 intermolecular recognition site; other site 481805004679 dimerization interface [polypeptide binding]; other site 481805004680 transcriptional regulator RcsB; Provisional; Region: PRK10840 481805004681 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805004682 active site 481805004683 phosphorylation site [posttranslational modification] 481805004684 intermolecular recognition site; other site 481805004685 dimerization interface [polypeptide binding]; other site 481805004686 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805004687 DNA binding residues [nucleotide binding] 481805004688 dimerization interface [polypeptide binding]; other site 481805004689 phosphotransfer intermediate protein in two-component regulatory system with RcsBC; Provisional; Region: PRK10618 481805004690 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805004691 ATP binding site [chemical binding]; other site 481805004692 G-X-G motif; other site 481805004693 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 481805004694 putative binding surface; other site 481805004695 active site 481805004696 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 481805004697 outer membrane porin protein C; Provisional; Region: PRK10554 481805004698 thiamine biosynthesis lipoprotein ApbE; Provisional; Region: PRK10461 481805004699 ApbE family; Region: ApbE; pfam02424 481805004700 bifunctional DNA-binding transcriptional dual regulator/O6-methylguanine-DNA methyltransferase; Provisional; Region: PRK15435 481805004701 Metal binding domain of Ada; Region: Ada_Zn_binding; pfam02805 481805004702 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805004703 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805004704 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 481805004705 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 481805004706 DNA binding site [nucleotide binding] 481805004707 active site 481805004708 alpha-ketoglutarate-dependent dioxygenase AlkB; Provisional; Region: PRK15401 481805004709 multidrug transporter membrane component/ATP-binding component; Provisional; Region: PRK10522 481805004710 ATP-binding cassette domain of multidrug resistance protein-like transporters; Region: ABCC_MRP_Like; cd03228 481805004711 Walker A/P-loop; other site 481805004712 ATP binding site [chemical binding]; other site 481805004713 Q-loop/lid; other site 481805004714 ABC transporter signature motif; other site 481805004715 Walker B; other site 481805004716 D-loop; other site 481805004717 H-loop/switch region; other site 481805004718 malate:quinone oxidoreductase; Validated; Region: PRK05257 481805004719 malate:quinone-oxidoreductase; Region: mal_quin_oxido; TIGR01320 481805004720 Protease Inhibitor Ecotin; homodimeric protease inhibitor; Region: Ecotin; cd00242 481805004721 secondary substrate binding site; other site 481805004722 primary substrate binding site; other site 481805004723 inhibition loop; other site 481805004724 dimerization interface [polypeptide binding]; other site 481805004725 ferredoxin-type protein; Provisional; Region: PRK10194 481805004726 assembly protein for periplasmic nitrate reductase; Provisional; Region: PRK10553 481805004727 nitrate reductase catalytic subunit; Provisional; Region: PRK13532 481805004728 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_Nitrate-R-NapA-like; cd02754 481805004729 [4Fe-4S] binding site [ion binding]; other site 481805004730 molybdopterin cofactor binding site; other site 481805004731 Nitrate reductases, NapA (Nitrate-R-NapA), NasA, and NarB catalyze the reduction of nitrate to nitrite. Monomeric Nas is located in the cytoplasm and participates in nitrogen assimilation. Dimeric Nap is located in the periplasm and is coupled to quinol...; Region: MopB_CT_Nitrate-R-NapA-like; cd02791 481805004732 molybdopterin cofactor binding site; other site 481805004733 quinol dehydrogenase periplasmic component; Provisional; Region: napG; PRK09476 481805004734 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 481805004735 4Fe-4S binding domain; Region: Fer4_5; pfam12801 481805004736 4Fe-4S binding domain; Region: Fer4_6; pfam12837 481805004737 nitrate reductase cytochrome C550 subunit; Provisional; Region: napB; PRK11586 481805004738 cytochrome c-type protein NapC; Provisional; Region: PRK10617 481805004739 Nitrate/TMAO reductases, membrane-bound tetraheme cytochrome c subunit [Energy production and conversion]; Region: TorC; COG3005 481805004740 cytochrome c biogenesis protein CcmA; Provisional; Region: PRK13538 481805004741 Cytochrome c biogenesis ATP-binding export protein; Region: ABC_CcmA_heme_exporter; cd03231 481805004742 Walker A/P-loop; other site 481805004743 ATP binding site [chemical binding]; other site 481805004744 Q-loop/lid; other site 481805004745 ABC transporter signature motif; other site 481805004746 Walker B; other site 481805004747 D-loop; other site 481805004748 H-loop/switch region; other site 481805004749 heme exporter protein CcmB; Region: ccmB; TIGR01190 481805004750 heme exporter protein CcmC; Region: ccmC; TIGR01191 481805004751 Heme exporter protein D [Intracellular trafficking and secretion]; Region: CcmD; COG3114 481805004752 cytochrome c-type biogenesis protein CcmE; Reviewed; Region: PRK13165 481805004753 c-type cytochrome biogenesis protein CcmF; Region: nrfE; TIGR00353 481805004754 thiol:disulfide interchange protein DsbE; Provisional; Region: PRK15412 481805004755 TlpA-like family, DsbE (also known as CcmG and CycY) subfamily; DsbE is a membrane-anchored, periplasmic TRX-like reductase containing a CXXC motif that specifically donates reducing equivalents to apocytochrome c via CcmH, another cytochrome c...; Region: TlpA_like_DsbE; cd03010 481805004756 catalytic residues [active] 481805004757 central insert; other site 481805004758 Uncharacterized protein involved in biosynthesis of c-type cytochromes [Posttranslational modification, protein turnover, chaperones]; Region: CcmH; COG3088 481805004759 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 481805004760 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481805004761 binding surface 481805004762 TPR motif; other site 481805004763 transcriptional regulator NarP; Provisional; Region: PRK10403 481805004764 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805004765 active site 481805004766 phosphorylation site [posttranslational modification] 481805004767 intermolecular recognition site; other site 481805004768 dimerization interface [polypeptide binding]; other site 481805004769 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805004770 DNA binding residues [nucleotide binding] 481805004771 dimerization interface [polypeptide binding]; other site 481805004772 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 481805004773 hypothetical protein; Provisional; Region: PRK09945 481805004774 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 481805004775 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 481805004776 Autotransporter beta-domain; Region: Autotransporter; pfam03797 481805004777 Predicted hydrolase of alkaline phosphatase superfamily [General function prediction only]; Region: COG3083 481805004778 Domain of unknown function (DUF3413); Region: DUF3413; pfam11893 481805004779 Sulfatase; Region: Sulfatase; pfam00884 481805004780 hypothetical protein; Provisional; Region: PRK13689 481805004781 Nucleoid-associated protein [General function prediction only]; Region: COG3081 481805004782 nucleoid-associated protein NdpA; Validated; Region: PRK00378 481805004783 Ribosomal L25/TL5/CTC N-terminal 5S rRNA binding domain; Region: Ribosomal_L25_TL5_CTC; cd00495 481805004784 5S rRNA interface [nucleotide binding]; other site 481805004785 CTC domain interface [polypeptide binding]; other site 481805004786 L16 interface [polypeptide binding]; other site 481805004787 DNA or RNA helicases of superfamily II [Transcription / DNA replication, recombination, and repair]; Region: SSL2; COG1061 481805004788 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481805004789 ATP binding site [chemical binding]; other site 481805004790 putative Mg++ binding site [ion binding]; other site 481805004791 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805004792 nucleotide binding region [chemical binding]; other site 481805004793 ATP-binding site [chemical binding]; other site 481805004794 Ribosomal L40e family; Region: Ribosomal_L40e; cl00671 481805004795 16S rRNA pseudouridylate synthase A; Provisional; Region: PRK10839 481805004796 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481805004797 RNA binding surface [nucleotide binding]; other site 481805004798 Pseudouridine synthase, Escherichia coli RsuA like; Region: PseudoU_synth_RsuA; cd02553 481805004799 active site 481805004800 uracil binding [chemical binding]; other site 481805004801 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805004802 bicyclomycin/multidrug efflux system; Provisional; Region: PRK11102 481805004803 putative substrate translocation pore; other site 481805004804 hypothetical protein; Provisional; Region: PRK11835 481805004805 microcin C ABC transporter ATP-binding protein YejF; Provisional; Region: PRK15134 481805004806 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805004807 Walker A/P-loop; other site 481805004808 ATP binding site [chemical binding]; other site 481805004809 Q-loop/lid; other site 481805004810 ABC transporter signature motif; other site 481805004811 Walker B; other site 481805004812 D-loop; other site 481805004813 H-loop/switch region; other site 481805004814 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 481805004815 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805004816 Walker A/P-loop; other site 481805004817 ATP binding site [chemical binding]; other site 481805004818 Q-loop/lid; other site 481805004819 ABC transporter signature motif; other site 481805004820 Walker B; other site 481805004821 D-loop; other site 481805004822 H-loop/switch region; other site 481805004823 microcin C ABC transporter permease; Provisional; Region: PRK15021 481805004824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805004825 dimer interface [polypeptide binding]; other site 481805004826 conserved gate region; other site 481805004827 ABC-ATPase subunit interface; other site 481805004828 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4174 481805004829 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805004830 dimer interface [polypeptide binding]; other site 481805004831 conserved gate region; other site 481805004832 putative PBP binding loops; other site 481805004833 ABC-ATPase subunit interface; other site 481805004834 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 481805004835 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_14; cd08497 481805004836 phage resistance protein; Provisional; Region: PRK10551 481805004837 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 481805004838 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805004839 outer membrane lipoprotein; Provisional; Region: spr; PRK10838 481805004840 NlpC/P60 family; Region: NLPC_P60; pfam00877 481805004841 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 481805004842 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 481805004843 active site 481805004844 Putative GTPases (G3E family) [General function prediction only]; Region: COG0523 481805004845 CobW/HypB/UreG, nucleotide-binding domain; Region: cobW; pfam02492 481805004846 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; smart00833 481805004847 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 481805004848 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 481805004849 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 481805004850 elongation factor P; Provisional; Region: PRK04542 481805004851 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 481805004852 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 481805004853 RNA binding site [nucleotide binding]; other site 481805004854 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 481805004855 RNA binding site [nucleotide binding]; other site 481805004856 Flagellin N-methylase; Region: FliB; pfam03692 481805004857 sugar efflux transporter B; Provisional; Region: PRK15011 481805004858 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805004859 putative substrate translocation pore; other site 481805004860 bifunctional PTS system fructose-specific transporter subunit IIA/HPr protein; Provisional; Region: PRK11109 481805004861 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481805004862 active site 481805004863 phosphorylation site [posttranslational modification] 481805004864 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 481805004865 dimerization domain swap beta strand [polypeptide binding]; other site 481805004866 regulatory protein interface [polypeptide binding]; other site 481805004867 active site 481805004868 regulatory phosphorylation site [posttranslational modification]; other site 481805004869 Fructose-1-phosphate kinase and related fructose-6-phosphate kinase (PfkB) [Carbohydrate transport and metabolism]; Region: FruK; COG1105 481805004870 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 481805004871 putative substrate binding site [chemical binding]; other site 481805004872 putative ATP binding site [chemical binding]; other site 481805004873 PTS system fructose-specific transporter subunits IIBC; Provisional; Region: PRK10712 481805004874 N-terminal domain of the phosphotransferase system fructose-specific component IIB [Carbohydrate transport and metabolism]; Region: COG3925 481805004875 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 481805004876 active site 481805004877 P-loop; other site 481805004878 phosphorylation site [posttranslational modification] 481805004879 PTS system, fructose subfamily, IIC component; Region: PTS_IIC_fructo; TIGR01427 481805004880 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 481805004881 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 481805004882 substrate binding site [chemical binding]; other site 481805004883 ATP binding site [chemical binding]; other site 481805004884 Indigoidine synthase A like protein; Region: Indigoidine_A; pfam04227 481805004885 Nucleoside permease [Nucleotide transport and metabolism]; Region: NupC; COG1972 481805004886 Na+ dependent nucleoside transporter N-terminus; Region: Nucleos_tra2_N; pfam01773 481805004887 Nucleoside recognition; Region: Gate; pfam07670 481805004888 Na+ dependent nucleoside transporter C-terminus; Region: Nucleos_tra2_C; pfam07662 481805004889 DNA-binding transcriptional activator YeiL; Provisional; Region: PRK10402 481805004890 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 481805004891 ligand binding site [chemical binding]; other site 481805004892 flexible hinge region; other site 481805004893 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 481805004894 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 481805004895 active site 481805004896 tetramer interface [polypeptide binding]; other site 481805004897 putative kinase; Provisional; Region: PRK09954 481805004898 Winged helix-turn-helix DNA-binding; Region: HTH_24; pfam13412 481805004899 YeiC-like sugar kinase. Found in eukaryotes and bacteria, YeiC-like kinase is part of the ribokinase/pfkB sugar kinase superfamily. Its oligomerization state is unknown at this time; Region: YeiC_kinase_like; cd01941 481805004900 substrate binding site [chemical binding]; other site 481805004901 ATP binding site [chemical binding]; other site 481805004902 endonuclease IV; Provisional; Region: PRK01060 481805004903 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 481805004904 AP (apurinic/apyrimidinic) site pocket; other site 481805004905 DNA interaction; other site 481805004906 Metal-binding active site; metal-binding site 481805004907 conserved hypothetical integral membrane protein; Region: TIGR00698 481805004908 putative DNA-binding transcriptional regulator; Provisional; Region: PRK10837 481805004909 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805004910 C-terminal substrate binding domain of LysR-type transcriptional regulator CysL, which activates the transcription of the cysJI operon encoding sulfite reductase, contains the type 2 periplasmic binding fold; Region: PBP2_CysL_like; cd08420 481805004911 putative dimerization interface [polypeptide binding]; other site 481805004912 lysine transporter; Provisional; Region: PRK10836 481805004913 catecholate siderophore receptor CirA; Provisional; Region: PRK10064 481805004914 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 481805004915 N-terminal plug; other site 481805004916 ligand-binding site [chemical binding]; other site 481805004917 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 481805004918 S-formylglutathione hydrolase; Region: PLN02442 481805004919 GTP cyclohydrolase I (GTP-CH-I) catalyzes the conversion of GTP into dihydroneopterin triphosphate. The enzyme product is the precursor of tetrahydrofolate in eubacteria, fungi, and plants and of the folate analogs in methanogenic bacteria. In...; Region: GTP_cyclohydro1; cd00642 481805004920 homodecamer interface [polypeptide binding]; other site 481805004921 GTP cyclohydrolase I; Provisional; Region: PLN03044 481805004922 active site 481805004923 putative catalytic site residues [active] 481805004924 zinc binding site [ion binding]; other site 481805004925 GTP-CH-I/GFRP interaction surface; other site 481805004926 Predicted membrane protein [Function unknown]; Region: COG2311 481805004927 hypothetical protein; Provisional; Region: PRK10835 481805004928 DNA-binding transcriptional regulator GalS; Provisional; Region: PRK10401 481805004929 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481805004930 DNA binding site [nucleotide binding] 481805004931 domain linker motif; other site 481805004932 Ligand binding domain of DNA transcription iso-repressor GalS, which is one of two regulatory proteins involved in galactose transport and metabolism; Region: PBP1_GalS_like; cd06270 481805004933 dimerization interface (closed form) [polypeptide binding]; other site 481805004934 ligand binding site [chemical binding]; other site 481805004935 methyl-galactoside ABC transporter galactose-binding periplasmic protein MglB; Provisional; Region: PRK15395 481805004936 Periplasmic glucose/galactose-binding protein (GGBP) involved in chemotaxis towards, and active transport of, glucose and galactose in various bacterial species; Region: PBP1_GGBP; cd01539 481805004937 ligand binding site [chemical binding]; other site 481805004938 calcium binding site [ion binding]; other site 481805004939 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 481805004940 galactose/methyl galaxtoside transporter ATP-binding protein; Provisional; Region: PRK10982 481805004941 Walker A/P-loop; other site 481805004942 ATP binding site [chemical binding]; other site 481805004943 Q-loop/lid; other site 481805004944 ABC transporter signature motif; other site 481805004945 Walker B; other site 481805004946 D-loop; other site 481805004947 H-loop/switch region; other site 481805004948 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481805004949 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481805004950 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481805004951 TM-ABC transporter signature motif; other site 481805004952 dihydropyrimidine dehydrogenase subunit B; Validated; Region: PRK08318 481805004953 Dihydropyrimidine dehydrogenase (DHPD) FMN-binding domain. DHPD catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines. DHPD contains two FAD, two FMN, and...; Region: DHPD_FMN; cd02940 481805004954 homodimer interface [polypeptide binding]; other site 481805004955 active site 481805004956 FMN binding site [chemical binding]; other site 481805004957 substrate binding site [chemical binding]; other site 481805004958 4Fe-4S binding domain; Region: Fer4; pfam00037 481805004959 dihydropyrimidine dehydrogenase subunit A; Provisional; Region: PRK11749 481805004960 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 481805004961 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805004962 Protein of unknown function (DUF2542); Region: DUF2542; pfam10808 481805004963 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 481805004964 putative active site [active] 481805004965 cytidine deaminase; Provisional; Region: PRK09027 481805004966 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 481805004967 active site 481805004968 catalytic motif [active] 481805004969 Zn binding site [ion binding]; other site 481805004970 Cytidine deaminase zinc-binding domain. These enzymes are Zn dependent. The zinc ion in the active site plays a central role in the proposed catalytic mechanism, activating a water molecule to form a hydroxide ion that performs a nucleophilic attack on...; Region: cytidine_deaminase; cd01283 481805004971 active site 481805004972 catalytic motif [active] 481805004973 Zn binding site [ion binding]; other site 481805004974 hypothetical protein; Provisional; Region: PRK10711 481805004975 hypothetical protein; Provisional; Region: PRK01821 481805004976 tRNA-dihydrouridine synthase C; Provisional; Region: PRK10550 481805004977 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 481805004978 FMN binding site [chemical binding]; other site 481805004979 active site 481805004980 catalytic residues [active] 481805004981 substrate binding site [chemical binding]; other site 481805004982 multidrug resistance outer membrane protein MdtQ; Provisional; Region: PRK11459 481805004983 oxidoreductase; Provisional; Region: PRK12743 481805004984 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481805004985 NAD(P) binding site [chemical binding]; other site 481805004986 active site 481805004987 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 481805004988 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 481805004989 Protein of unknown function (DUF1282); Region: DUF1282; pfam06930 481805004990 D-alanyl-D-alanine endopeptidase; Provisional; Region: pbpG; PRK11669 481805004991 D-alanyl-D-alanine carboxypeptidase; Region: Peptidase_S11; pfam00768 481805004992 D-lactate dehydrogenase; Provisional; Region: PRK11183 481805004993 FAD binding domain; Region: FAD_binding_4; pfam01565 481805004994 D-lactate dehydrogenase, membrane binding; Region: Lact-deh-memb; pfam09330 481805004995 beta-D-glucoside glucohydrolase; Provisional; Region: PRK15098 481805004996 Glycosyl hydrolase family 3 N terminal domain; Region: Glyco_hydro_3; pfam00933 481805004997 Fibronectin type III-like domain; Region: Fn3-like; pfam14310 481805004998 Substrate binding domain of ABC-type glycine betaine transport system; Region: OpuAC; pfam04069 481805004999 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805005000 dimer interface [polypeptide binding]; other site 481805005001 conserved gate region; other site 481805005002 ABC-ATPase subunit interface; other site 481805005003 ABC-type proline/glycine betaine transport systems, ATPase components [Amino acid transport and metabolism]; Region: OpuBA; COG1125 481805005004 ATP-binding cassette domain of the osmoprotectant transporter; Region: ABC_OpuCA_Osmoprotection; cd03295 481805005005 Walker A/P-loop; other site 481805005006 ATP binding site [chemical binding]; other site 481805005007 Q-loop/lid; other site 481805005008 ABC transporter signature motif; other site 481805005009 Walker B; other site 481805005010 D-loop; other site 481805005011 H-loop/switch region; other site 481805005012 CBS domain; Region: CBS; pfam00571 481805005013 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 481805005014 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805005015 dimer interface [polypeptide binding]; other site 481805005016 conserved gate region; other site 481805005017 putative PBP binding loops; other site 481805005018 ABC-ATPase subunit interface; other site 481805005019 transcriptional regulator MirA; Provisional; Region: PRK15043 481805005020 Helix-Turn-Helix DNA binding domain of MlrA-like transcription regulators; Region: HTH_MlrA-like; cd04763 481805005021 DNA binding residues [nucleotide binding] 481805005022 Putative regulator of cell autolysis [Signal transduction mechanisms]; Region: LytS; COG3275 481805005023 5TMR of 5TMR-LYT; Region: 5TM-5TMR_LYT; pfam07694 481805005024 GAF domain; Region: GAF; pfam01590 481805005025 Histidine kinase; Region: His_kinase; pfam06580 481805005026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805005027 ATP binding site [chemical binding]; other site 481805005028 Mg2+ binding site [ion binding]; other site 481805005029 G-X-G motif; other site 481805005030 putative two-component response-regulatory protein YehT; Provisional; Region: PRK11697 481805005031 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805005032 active site 481805005033 phosphorylation site [posttranslational modification] 481805005034 intermolecular recognition site; other site 481805005035 dimerization interface [polypeptide binding]; other site 481805005036 LytTr DNA-binding domain; Region: LytTR; pfam04397 481805005037 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4807 481805005038 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 481805005039 Protein of unknown function (DUF1456); Region: DUF1456; pfam07308 481805005040 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4808 481805005041 MoxR-like ATPases [General function prediction only]; Region: COG0714 481805005042 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805005043 Walker A motif; other site 481805005044 ATP binding site [chemical binding]; other site 481805005045 Walker B motif; other site 481805005046 arginine finger; other site 481805005047 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 481805005048 WGR domain of molybdate metabolism regulator and related proteins; Region: WGR_MMR_like; cd07996 481805005049 Domain of unknown function (DUF4132); Region: DUF4132; pfam13569 481805005050 methionyl-tRNA synthetase; Reviewed; Region: metG; PRK00133 481805005051 catalytic core domain of methioninyl-tRNA synthetases; Region: MetRS_core; cd00814 481805005052 active site 481805005053 HIGH motif; other site 481805005054 KMSKS motif; other site 481805005055 Anticodon-binding domain of methionyl tRNA synthetases; Region: Anticodon_Ia_Met; cd07957 481805005056 tRNA binding surface [nucleotide binding]; other site 481805005057 anticodon binding site; other site 481805005058 tRNA-binding-domain-containing Escherichia coli methionyl-tRNA synthetase (EcMetRS)-like proteins. This family includes EcMetRS and Aquifex aeolicus Trbp111 (AaTrbp111). This domain has general tRNA binding properties. MetRS aminoacylates methionine...; Region: tRNA_bind_EcMetRS_like; cd02800 481805005059 dimer interface [polypeptide binding]; other site 481805005060 putative tRNA-binding site [nucleotide binding]; other site 481805005061 antiporter inner membrane protein; Provisional; Region: PRK11670 481805005062 MRP (Multiple Resistance and pH adaptation) is a homologue of the Fer4_NifH superfamily. Like the other members of the superfamily, MRP contains a ATP-binding domain at the N-termini. It is found in bacteria as a membrane-spanning protein and functions...; Region: MRP-like; cd02037 481805005063 Walker A motif; other site 481805005064 Protein of unknown function (DUF2574); Region: DUF2574; pfam10836 481805005065 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 481805005066 putative fimbrial assembly chaperone protein StcB; Provisional; Region: PRK15253 481805005067 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 481805005068 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 481805005069 fimbrial outer membrane usher protein; Provisional; Region: PRK15217 481805005070 PapC N-terminal domain; Region: PapC_N; pfam13954 481805005071 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 481805005072 PapC C-terminal domain; Region: PapC_C; pfam13953 481805005073 putative fimbrial-like adhesin protein StcD; Provisional; Region: PRK15252 481805005074 putative fimbrial biosynthesis regulatory protein; Provisional; Region: PRK15216 481805005075 Predicted integral membrane protein [Function unknown]; Region: COG5455 481805005076 nickel/cobalt efflux protein RcnA; Provisional; Region: PRK10019 481805005077 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 481805005078 putative metal binding site [ion binding]; other site 481805005079 putative homodimer interface [polypeptide binding]; other site 481805005080 putative homotetramer interface [polypeptide binding]; other site 481805005081 putative homodimer-homodimer interface [polypeptide binding]; other site 481805005082 putative allosteric switch controlling residues; other site 481805005083 4-methyl-5-beta-hydroxyethylthiazole (Thz) kinase catalyzes the phosphorylation of the hydroxylgroup of Thz. A reaction that allows cells to recycle Thz into the thiamine biosynthesis pathway, as an alternative to its synthesis from cysteine, tyrosine...; Region: THZ_kinase; cd01170 481805005084 substrate binding site [chemical binding]; other site 481805005085 multimerization interface [polypeptide binding]; other site 481805005086 ATP binding site [chemical binding]; other site 481805005087 4-amino-5-hydroxymethyl-2-methyl-pyrimidine phosphate kinase (HMPP-kinase) catalyzes two consecutive phosphorylation steps in the thiamine phosphate biosynthesis pathway, leading to the synthesis of vitamin B1. The first step is the phosphorylation of...; Region: HMPP_kinase; cd01169 481805005088 dimer interface [polypeptide binding]; other site 481805005089 substrate binding site [chemical binding]; other site 481805005090 ATP binding site [chemical binding]; other site 481805005091 Lyzozyme M1 (1,4-beta-N-acetylmuramidase) [Cell envelope biogenesis, outer membrane]; Region: Acm; COG3757 481805005092 YegX is an uncharacterized bacterial protein with a glycosyl hydrolase family 25 (GH25) catalytic domain that is similar in sequence to the CH-type (Chalaropsis-type) lysozymes of the GH25 family of endolysins; Region: GH25_YegX-like; cd06524 481805005093 active site 481805005094 Transcriptional regulators [Transcription]; Region: PhnF; COG2188 481805005095 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805005096 DNA-binding site [nucleotide binding]; DNA binding site 481805005097 UTRA domain; Region: UTRA; pfam07702 481805005098 ADP-ribosylglycohydrolase [Posttranslational modification, protein turnover, chaperones]; Region: DraG; COG1397 481805005099 nucleoside transporter; Region: 2A0110; TIGR00889 481805005100 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805005101 putative substrate translocation pore; other site 481805005102 fructose-bisphosphate aldolase; Provisional; Region: PRK09250 481805005103 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 481805005104 putative active site; other site 481805005105 catalytic residue [active] 481805005106 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 481805005107 fructose-bisphosphate aldolase; Provisional; Region: PRK09197 481805005108 intersubunit interface [polypeptide binding]; other site 481805005109 active site 481805005110 zinc binding site [ion binding]; other site 481805005111 Na+ binding site [ion binding]; other site 481805005112 D-tagatose-1,6-bisphosphate aldolase subunit GatZ; Provisional; Region: PRK15052 481805005113 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481805005114 active site 481805005115 phosphorylation site [posttranslational modification] 481805005116 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 481805005117 active site 481805005118 P-loop; other site 481805005119 phosphorylation site [posttranslational modification] 481805005120 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 481805005121 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 481805005122 galactitol-1-phosphate dehydrogenase; Provisional; Region: PRK10309 481805005123 NAD(P)-dependent sugar dehydrogenases; Region: sugar_DH; cd08236 481805005124 putative NAD(P) binding site [chemical binding]; other site 481805005125 catalytic Zn binding site [ion binding]; other site 481805005126 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 481805005127 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 481805005128 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481805005129 lipid kinase; Reviewed; Region: PRK13054 481805005130 Diacylglycerol kinase catalytic domain; Region: DAGK_cat; pfam00781 481805005131 putative protease; Provisional; Region: PRK15452 481805005132 Peptidase family U32; Region: Peptidase_U32; pfam01136 481805005133 Uncharacterized conserved protein [Function unknown]; Region: COG3422 481805005134 Domain of unknown function (DUF1508); Region: DUF1508; pfam07411 481805005135 DNA-binding transcriptional regulator BaeR; Provisional; Region: PRK10710 481805005136 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805005137 active site 481805005138 phosphorylation site [posttranslational modification] 481805005139 intermolecular recognition site; other site 481805005140 dimerization interface [polypeptide binding]; other site 481805005141 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805005142 DNA binding site [nucleotide binding] 481805005143 signal transduction histidine-protein kinase BaeS; Provisional; Region: PRK10549 481805005144 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805005145 dimerization interface [polypeptide binding]; other site 481805005146 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805005147 dimer interface [polypeptide binding]; other site 481805005148 phosphorylation site [posttranslational modification] 481805005149 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805005150 ATP binding site [chemical binding]; other site 481805005151 Mg2+ binding site [ion binding]; other site 481805005152 G-X-G motif; other site 481805005153 putative transporter; Provisional; Region: PRK10504 481805005154 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805005155 putative substrate translocation pore; other site 481805005156 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805005157 multidrug efflux system subunit MdtC; Provisional; Region: PRK10614 481805005158 multidrug efflux system subunit MdtB; Provisional; Region: PRK10503 481805005159 Protein export membrane protein; Region: SecD_SecF; cl14618 481805005160 multidrug efflux system subunit MdtA; Provisional; Region: PRK11556 481805005161 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481805005162 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805005163 VWA subfamily: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: vWA_subfamily; cd01464 481805005164 metal ion-dependent adhesion site (MIDAS); other site 481805005165 Protein phosphatase 2C; Region: PP2C_2; pfam13672 481805005166 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805005167 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805005168 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805005169 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805005170 Uncharacterized protein with protein kinase and helix-hairpin-helix DNA-binding domains [General function prediction only]; Region: COG4248 481805005171 Protein Kinases, catalytic domain; Region: PKc_like; cl09925 481805005172 substrate binding site [chemical binding]; other site 481805005173 activation loop (A-loop); other site 481805005174 Y-family of DNA polymerases; Region: PolY; cl12025 481805005175 putative chaperone; Provisional; Region: PRK11678 481805005176 Escherichia coli YegD, a putative chaperone protein, and related proteins; Region: YegD_like; cd10231 481805005177 nucleotide binding site [chemical binding]; other site 481805005178 putative NEF/HSP70 interaction site [polypeptide binding]; other site 481805005179 SBD interface [polypeptide binding]; other site 481805005180 3-methyl-adenine DNA glycosylase II; Provisional; Region: PRK10308 481805005181 AlkA N-terminal domain; Region: AlkA_N; smart01009 481805005182 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 481805005183 minor groove reading motif; other site 481805005184 helix-hairpin-helix signature motif; other site 481805005185 substrate binding pocket [chemical binding]; other site 481805005186 active site 481805005187 Predicted integral membrane sensor domain [Signal transduction mechanisms]; Region: COG3447 481805005188 putative diguanylate cyclase; Provisional; Region: PRK09776 481805005189 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481805005190 putative active site [active] 481805005191 heme pocket [chemical binding]; other site 481805005192 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481805005193 putative active site [active] 481805005194 heme pocket [chemical binding]; other site 481805005195 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481805005196 putative active site [active] 481805005197 heme pocket [chemical binding]; other site 481805005198 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805005199 metal binding site [ion binding]; metal-binding site 481805005200 active site 481805005201 I-site; other site 481805005202 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805005203 Uridine kinase [Nucleotide transport and metabolism]; Region: Udk; COG0572 481805005204 Uridine monophosphate kinase (UMPK, EC 2.7.1.48), also known as uridine kinase or uridine-cytidine kinase (UCK), catalyzes the reversible phosphoryl transfer from ATP to uridine or cytidine to yield UMP or CMP. In the primidine nucleotide-salvage pathway; Region: UMPK; cd02023 481805005205 ATP-binding site [chemical binding]; other site 481805005206 Sugar specificity; other site 481805005207 Pyrimidine base specificity; other site 481805005208 Trimeric dUTP diphosphatases; Region: trimeric_dUTPase; cd07557 481805005209 trimer interface [polypeptide binding]; other site 481805005210 active site 481805005211 putative assembly protein; Provisional; Region: PRK10833 481805005212 AsmA-like C-terminal region; Region: AsmA_2; pfam13502 481805005213 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 481805005214 FOG: CBS domain [General function prediction only]; Region: COG0517 481805005215 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 481805005216 Transporter associated domain; Region: CorC_HlyC; smart01091 481805005217 polysaccharide export protein Wza; Provisional; Region: PRK15078 481805005218 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 481805005219 SLBB domain; Region: SLBB; pfam10531 481805005220 Low molecular weight phosphatase family; Region: LMWPc; cd00115 481805005221 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 481805005222 active site 481805005223 tyrosine kinase; Provisional; Region: PRK11519 481805005224 Chain length determinant protein; Region: Wzz; pfam02706 481805005225 Chain length determinant protein; Region: Wzz; cl15801 481805005226 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 481805005227 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 481805005228 putative glycosyl transferase; Provisional; Region: PRK10018 481805005229 Glycosyl transferase family 2; Region: Glycos_transf_2; pfam00535 481805005230 active site 481805005231 putative acyl transferase; Provisional; Region: PRK10191 481805005232 Serine acetyltransferase (SAT): SAT catalyzes the CoA-dependent acetylation of the side chain hydroxyl group of L-serine to form O-acetylserine, as the first step of a two-step biosynthetic pathway in bacteria and plants leading to the formation of...; Region: LbH_SAT; cd03354 481805005233 trimer interface [polypeptide binding]; other site 481805005234 active site 481805005235 substrate binding site [chemical binding]; other site 481805005236 CoA binding site [chemical binding]; other site 481805005237 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 481805005238 colanic acid biosynthesis glycosyl transferase WcaC; Region: WcaC; TIGR04015 481805005239 putative colanic acid polymerase WcaD; Region: WcaD; TIGR04010 481805005240 putative glycosyl transferase; Provisional; Region: PRK10063 481805005241 WfgS and WfeV are involved in O-antigen biosynthesis; Region: GT_2_WfgS_like; cd06433 481805005242 metal-binding site 481805005243 colanic acid biosynthesis acetyltransferase WcaF; Region: WcaF; TIGR04008 481805005244 wcaF-like: This group is composed of the protein product of the E. coli wcaF gene and similar proteins. WcaF is part of the gene cluster responsible for the biosynthesis of the extracellular polysaccharide colanic acid. The wcaF protein is predicted to...; Region: LbH_wcaF_like; cd05825 481805005245 putative trimer interface [polypeptide binding]; other site 481805005246 putative active site [active] 481805005247 putative substrate binding site [chemical binding]; other site 481805005248 putative CoA binding site [chemical binding]; other site 481805005249 GDP-D-mannose dehydratase [Cell envelope biogenesis, outer membrane]; Region: Gmd; COG1089 481805005250 GDP-mannose 4,6 dehydratase, extended (e) SDRs; Region: GDP_MD_SDR_e; cd05260 481805005251 NADP-binding site; other site 481805005252 homotetramer interface [polypeptide binding]; other site 481805005253 substrate binding site [chemical binding]; other site 481805005254 homodimer interface [polypeptide binding]; other site 481805005255 active site 481805005256 GDP-fucose synthetase, extended (e) SDRs; Region: GDP_FS_SDR_e; cd05239 481805005257 GDP-4-keto-6-deoxymannose-3, 5-epimerase-4-reductase; Region: PLN02725 481805005258 NADP binding site [chemical binding]; other site 481805005259 active site 481805005260 putative substrate binding site [chemical binding]; other site 481805005261 GDP-mannose glycosyl hydrolase (AKA GDP-mannose mannosyl hydrolase (GDPMH)) is a member of the Nudix hydrolase superfamily. This class of enzymes is unique from other members of the superfamily in two aspects. First, it contains a modified Nudix...; Region: GDPMH; cd03430 481805005262 active site 481805005263 GDP-Mannose binding site [chemical binding]; other site 481805005264 dimer interface [polypeptide binding]; other site 481805005265 modified nudix motif 481805005266 metal binding site [ion binding]; metal-binding site 481805005267 colanic acid biosynthesis glycosyl transferase WcaI; Region: wcaI; TIGR04007 481805005268 This family is most closely related to the GT1 family of glycosyltransferases. wbuB in E. coli is involved in the biosynthesis of the O26 O-antigen. It has been proposed to function as an N-acetyl-L-fucosamine (L-FucNAc) transferase; Region: GT1_wbuB_like; cd03794 481805005269 mannose-1-phosphate guanyltransferase; Provisional; Region: cpsB; PRK15460 481805005270 GDP-M1P_Guanylyltransferase catalyzes the formation of GDP-Mannose; Region: GDP-M1P_Guanylyltransferase; cd02509 481805005271 Substrate binding site; other site 481805005272 Mannose-6-phosphate isomerase; Region: MannoseP_isomer; pfam01050 481805005273 phosphomannomutase CpsG; Provisional; Region: PRK15414 481805005274 The phosphomannomutase/phosphoglucomutase (PMM/PGM) bifunctional enzyme catalyzes the reversible conversion of 1-phospho to 6-phospho-sugars (e.g. between mannose-1-phosphate and mannose-6-phosphate or glucose-1-phosphate and glucose-6-phosphate) via a...; Region: PMM_PGM; cd03089 481805005275 active site 481805005276 substrate binding site [chemical binding]; other site 481805005277 metal binding site [ion binding]; metal-binding site 481805005278 putative UDP-glucose lipid carrier transferase; Provisional; Region: PRK10124 481805005279 Sugar transferases involved in lipopolysaccharide synthesis [Cell envelope biogenesis, outer membrane]; Region: WcaJ; COG2148 481805005280 colanic acid exporter; Provisional; Region: PRK10459 481805005281 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_tuaB_like; cd13127 481805005282 Polysaccharide pyruvyl transferase family protein [Cell wall/membrane/envelope biogenesis]; Region: WcaK; COG2327 481805005283 colanic acid biosynthesis pyruvyl transferase WcaK; Region: wcaK; TIGR04006 481805005284 colanic acid biosynthesis glycosyltransferase WcaL; Region: wcaL; TIGR04005 481805005285 This is a family of GT1 glycosyltransferases found specifically in certain bacteria. amsK in Erwinia amylovora, has been reported to be involved in the biosynthesis of amylovoran, a exopolysaccharide acting as a virulence factor; Region: GT1_amsK_like; cd03799 481805005286 putative ADP-binding pocket [chemical binding]; other site 481805005287 putative colanic acid biosynthesis protein; Provisional; Region: wcaM; PRK10123 481805005288 Escherichia coli Gne (a nucleoside-diphosphate-sugar 4-epimerase)-like, extended (e) SDRs; Region: Gne_like_SDR_e; cd05238 481805005289 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 481805005290 putative NAD(P) binding site [chemical binding]; other site 481805005291 active site 481805005292 putative substrate binding site [chemical binding]; other site 481805005293 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 481805005294 active site 481805005295 tetramer interface; other site 481805005296 dTDP-glucose 4,6 dehydratase; Provisional; Region: PRK10084 481805005297 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 481805005298 NAD binding site [chemical binding]; other site 481805005299 substrate binding site [chemical binding]; other site 481805005300 homodimer interface [polypeptide binding]; other site 481805005301 active site 481805005302 dTDP-4-dehydrorhamnose reductase; Provisional; Region: PRK09987 481805005303 dTDP-6-deoxy-L-lyxo-4-hexulose reductase and related proteins, extended (e) SDRs; Region: dTDP_HR_like_SDR_e; cd05254 481805005304 NADP binding site [chemical binding]; other site 481805005305 active site 481805005306 putative substrate binding site [chemical binding]; other site 481805005307 glucose-1-phosphate thymidylyltransferase RfbA; Provisional; Region: PRK15480 481805005308 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 481805005309 substrate binding site; other site 481805005310 tetramer interface; other site 481805005311 dTDP-4-dehydrorhamnose 3,5-epimerase; Region: dTDP_sugar_isom; pfam00908 481805005312 Proteins of this family catalyze the reduction of flavin or nitrocompounds using NAD(P)H as electron donor in a obligatory two-electron transfer, utilizing FMN or FAD as cofactor. They are often found to be homodimers. Enzymes of this family are...; Region: Nitro_FMN_reductase; cd02062 481805005313 FMN binding site [chemical binding]; other site 481805005314 dimer interface [polypeptide binding]; other site 481805005315 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 481805005316 Polysaccharide pyruvyl transferase; Region: PS_pyruv_trans; pfam04230 481805005317 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 481805005318 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 481805005319 RfbF is a putative dTDP-rhamnosyl transferase; Region: GT2_RfbF_like; cd02526 481805005320 L-rhamnosyltransferase; Region: rhamnosyltran; TIGR01556 481805005321 Ligand binding site; other site 481805005322 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805005323 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805005324 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805005325 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805005326 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 481805005327 6-phosphogluconate dehydrogenase; Validated; Region: PRK09287 481805005328 6-phosphogluconate dehydrogenase, C-terminal domain; Region: 6PGD; pfam00393 481805005329 UDP-glucose 6-dehydrogenase; Provisional; Region: PRK15057 481805005330 NAD-dependent glycerol-3-phosphate dehydrogenase N-terminus; Region: NAD_Gly3P_dh_N; pfam01210 481805005331 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 481805005332 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 481805005333 chain length determinant protein WzzB; Provisional; Region: PRK15471 481805005334 Chain length determinant protein; Region: Wzz; pfam02706 481805005335 Phosphoribosyl-AMP cyclohydrolase [Amino acid transport and metabolism]; Region: HisI; COG0139 481805005336 bifunctional phosphoribosyl-AMP cyclohydrolase/phosphoribosyl-ATP pyrophosphatase protein; Reviewed; Region: PRK02759 481805005337 Nucleoside Triphosphate Pyrophosphohydrolase (EC 3.6.1.8) MazG-like domain found in Escherichia coli phosphoribosyl-ATP pyrophosphohydrolase (HisIE or PRATP-PH) and its homologs; Region: NTP-PPase_HisIE_like; cd11534 481805005338 metal binding site [ion binding]; metal-binding site 481805005339 The cyclase subunit of imidazoleglycerol phosphate synthase (HisF). Imidazole glycerol phosphate synthase (IGPS) catalyzes the fifth step of histidine biosynthesis, the formation of the imidazole ring. IGPS converts N1-(5'-phosphoribulosyl)...; Region: HisF; cd04731 481805005340 Histidine biosynthesis protein; Region: His_biosynth; pfam00977 481805005341 substrate binding site [chemical binding]; other site 481805005342 glutamase interaction surface [polypeptide binding]; other site 481805005343 HisA. Phosphoribosylformimino-5-aminoimidazole carboxamide ribonucleotide (ProFAR) isomerase catalyzes the fourth step in histidine biosynthesis, an isomerisation of the aminoaldose moiety of ProFAR to the aminoketose of PRFAR (N-(5'-phospho-D-1...; Region: HisA; cd04732 481805005344 phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; Region: TIGR00007 481805005345 catalytic residues [active] 481805005346 imidazole glycerol phosphate synthase subunit HisH; Provisional; Region: hisH; PRK13170 481805005347 Type 1 glutamine amidotransferase (GATase1) domain found in imidazole glycerol phosphate synthase (IGPS); Region: GATase1_IGP_Synthase; cd01748 481805005348 putative active site [active] 481805005349 oxyanion strand; other site 481805005350 catalytic triad [active] 481805005351 imidazole glycerol-phosphate dehydratase/histidinol phosphatase; Provisional; Region: PRK05446 481805005352 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805005353 active site 481805005354 motif I; other site 481805005355 motif II; other site 481805005356 Imidazoleglycerol-phosphate dehydratase; Region: IGPD; cd07914 481805005357 putative active site pocket [active] 481805005358 4-fold oligomerization interface [polypeptide binding]; other site 481805005359 metal binding residues [ion binding]; metal-binding site 481805005360 3-fold/trimer interface [polypeptide binding]; other site 481805005361 histidinol-phosphate aminotransferase; Provisional; Region: PRK01688 481805005362 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481805005363 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805005364 homodimer interface [polypeptide binding]; other site 481805005365 catalytic residue [active] 481805005366 Histidinol dehydrogenase; Region: Histidinol_dh; pfam00815 481805005367 Histidinol dehydrogenase, HisD, E.C 1.1.1.23. Histidinol dehydrogenase catalyzes the last two steps in the L-histidine biosynthesis pathway, which is conserved in bacteria, archaea, fungi, and plants. These last two steps are (i) the NAD-dependent...; Region: Histidinol_dh; cd06572 481805005368 NAD binding site [chemical binding]; other site 481805005369 dimerization interface [polypeptide binding]; other site 481805005370 product binding site; other site 481805005371 substrate binding site [chemical binding]; other site 481805005372 zinc binding site [ion binding]; other site 481805005373 catalytic residues [active] 481805005374 ATP phosphoribosyltransferase; Reviewed; Region: hisG; PRK00489 481805005375 ATP phosphoribosyltransferase; Region: hisG; TIGR00070 481805005376 ATP phosphoribosyltransferase, C-terminal domain; Region: HisG_C-term; TIGR03455 481805005377 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 481805005378 atypical (a) SDRs, subgroup 4; Region: SDR_a4; cd05266 481805005379 putative NAD(P) binding site [chemical binding]; other site 481805005380 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805005381 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 481805005382 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481805005383 dimerization interface [polypeptide binding]; other site 481805005384 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 481805005385 putative selenium metabolism protein, YedE family; Region: seleno_YedE; TIGR04112 481805005386 Sulphur transport; Region: Sulf_transp; pfam04143 481805005387 SirA, YedF, and YeeD. Two-layered alpha/beta sandwich domain. SirA (also known as UvrY, and YhhP) belongs to a family of bacterial two-component response regulators that controls secondary metabolism and virulence. The other member of this...; Region: SirA_YedF_YeeD; cd00291 481805005388 CPxP motif; other site 481805005389 exonuclease I; Provisional; Region: sbcB; PRK11779 481805005390 N-terminal DEDDh 3'-5' exonuclease domain of Escherichia coli exonuclease I and similar proteins; Region: ExoI_N; cd06138 481805005391 active site 481805005392 catalytic site [active] 481805005393 substrate binding site [chemical binding]; other site 481805005394 Exonuclease C-terminal; Region: Exonuc_X-T_C; pfam08411 481805005395 D-alanyl-D-alanine carboxypeptidase; Provisional; Region: dacD; PRK11397 481805005396 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 481805005397 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; pfam07943 481805005398 DNA gyrase inhibitor; Provisional; Region: PRK10016 481805005399 Predicted membrane protein [Function unknown]; Region: COG1289 481805005400 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 481805005401 hypothetical protein; Provisional; Region: PRK05423 481805005402 Adenosylcobinamide kinase / adenosylcobinamide phosphate guanyltransferase (CobU). CobU is bifunctional cobalbumin biosynthesis enzymes which display adenosylcobinamide kinase and adenosylcobinamide phosphate guanyltransferase activity. This enzyme is a...; Region: CobU; cd00544 481805005403 homotrimer interface [polypeptide binding]; other site 481805005404 Walker A motif; other site 481805005405 GTP binding site [chemical binding]; other site 481805005406 Walker B motif; other site 481805005407 Cobalamin-5-phosphate synthase; Region: CobS; cl00415 481805005408 Phosphoribosyltransferase; Region: DBI_PRT; pfam02277 481805005409 Nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase (DMB-PRT), also called CobT; Region: DMB-PRT_CobT; cd02439 481805005410 putative dimer interface [polypeptide binding]; other site 481805005411 active site pocket [active] 481805005412 putative cataytic base [active] 481805005413 L,D-transpeptidase; Provisional; Region: PRK10190 481805005414 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 481805005415 Transcriptional regulator, contains sigma factor-related N-terminal domain [Transcription]; Region: DeoR; COG2390 481805005416 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 481805005417 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481805005418 active site 481805005419 phosphorylation site [posttranslational modification] 481805005420 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 481805005421 active site 481805005422 P-loop; other site 481805005423 phosphorylation site [posttranslational modification] 481805005424 Phosphotransferase system, galactitol-specific IIC component [Carbohydrate transport and metabolism]; Region: GatC; COG3775 481805005425 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 481805005426 Ribose/Galactose Isomerase; Region: LacAB_rpiB; cl00485 481805005427 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 481805005428 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 481805005429 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481805005430 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481805005431 active site 481805005432 phosphorylation site [posttranslational modification] 481805005433 PTS_IIB_galactitol: subunit IIB of enzyme II (EII) of the galactitol-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is a galactitol-specific permease with two cytoplasmic domains (IIA and IIB) and a...; Region: PTS_IIB_galactitol; cd05566 481805005434 active site 481805005435 P-loop; other site 481805005436 phosphorylation site [posttranslational modification] 481805005437 PTS system sugar-specific permease component; Region: EIIC-GAT; cl04451 481805005438 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 481805005439 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 481805005440 substrate binding site [chemical binding]; other site 481805005441 hexamer interface [polypeptide binding]; other site 481805005442 metal binding site [ion binding]; metal-binding site 481805005443 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05653 481805005444 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481805005445 NAD(P) binding site [chemical binding]; other site 481805005446 active site 481805005447 Hexulose-6-phosphate isomerase (PHI). PHI is a member of the SIS (Sugar ISomerase domain) superfamily. In the ribulose monophosphate pathway of formaldehyde fixation, hexulose-6-phosphate synthase catalyzes the condensation of ribulose-5-phosphate with...; Region: SIS_PHI; cd05005 481805005448 tetramer interface [polypeptide binding]; other site 481805005449 Transcriptional regulators [Transcription]; Region: RpiR; COG1737 481805005450 active site 481805005451 PAAR motif; Region: PAAR_motif; cl15808 481805005452 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805005453 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 481805005454 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805005455 RHS Repeat; Region: RHS_repeat; pfam05593 481805005456 RHS Repeat; Region: RHS_repeat; pfam05593 481805005457 RHS protein; Region: RHS; pfam03527 481805005458 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 481805005459 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 481805005460 Integrase; Region: Integrase_1; pfam12835 481805005461 nitrogen assimilation transcriptional regulator; Provisional; Region: PRK11233 481805005462 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805005463 The C-teminal substrate binding domain of LysR-like nitrogen assimilation control (NAC) protein, contains the type 2 periplasmic binding fold; Region: PBP2_Nac; cd08433 481805005464 putative dimerization interface [polypeptide binding]; other site 481805005465 transcriptional regulator Cbl; Reviewed; Region: cbl; PRK12679 481805005466 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805005467 The C-terminal substrate binding domain of LysR-type transcriptional regulator Cbl, which is required for expression of sulfate starvation-inducible (ssi) genes, contains the type 2 periplasmic binding fold; Region: PBP2_Cbl; cd08444 481805005468 putative substrate binding site [chemical binding]; other site 481805005469 dimerization interface [polypeptide binding]; other site 481805005470 MATE family multidrug exporter; Provisional; Region: PRK10189 481805005471 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Thermotoga marina NorM; Region: MATE_NorM_like; cd13137 481805005472 hypothetical protein; Provisional; Region: PRK12378 481805005473 AMP nucleosidase; Provisional; Region: PRK08292 481805005474 Bacterial AMP nucleoside phosphorylase N-terminus; Region: AMNp_N; pfam10423 481805005475 Nucleoside phosphorylase [Nucleotide transport and metabolism]; Region: Pfs; COG0775 481805005476 shikimate transporter; Provisional; Region: PRK09952 481805005477 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805005478 putative substrate translocation pore; other site 481805005479 ADP-heptose:LPS heptosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaF; COG0859 481805005480 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 481805005481 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805005482 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 481805005483 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805005484 RHS Repeat; Region: RHS_repeat; pfam05593 481805005485 RHS Repeat; Region: RHS_repeat; pfam05593 481805005486 RHS protein; Region: RHS; pfam03527 481805005487 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 481805005488 Phage integrase, N-terminal; Region: Integrase_l_N; pfam12834 481805005489 Integrase; Region: Integrase_1; pfam12835 481805005490 DgsA anti-repressor MtfA; Provisional; Region: PRK15410 481805005491 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 481805005492 zinc/cadmium-binding protein; Provisional; Region: PRK10306 481805005493 putative sulfite oxidase subunit YedZ; Reviewed; Region: PRK05419 481805005494 TMAO/DMSO reductase; Reviewed; Region: PRK05363 481805005495 YedY_like molybdopterin cofactor (Moco) binding domain, a subgroup of the sulfite oxidase (SO) family of molybdopterin binding domains. Escherichia coli YedY has been propsed to form a heterodimer, consisting of a soluble catalytic subunit termed YedY; Region: YedY_like_Moco; cd02107 481805005496 Moco binding site; other site 481805005497 metal coordination site [ion binding]; other site 481805005498 HIUase (5-hydroxyisourate hydrolase) catalyzes the second step in a three-step ureide pathway in which 5-hydroxyisourate (HIU), a product of the uricase (urate oxidase) reaction, is hydrolyzed to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU); Region: TLP_HIUase; cd05822 481805005499 active site 481805005500 homotetramer interface [polypeptide binding]; other site 481805005501 transcriptional regulatory protein YedW; Provisional; Region: PRK11517 481805005502 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805005503 active site 481805005504 phosphorylation site [posttranslational modification] 481805005505 intermolecular recognition site; other site 481805005506 dimerization interface [polypeptide binding]; other site 481805005507 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805005508 DNA binding site [nucleotide binding] 481805005509 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 481805005510 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805005511 dimer interface [polypeptide binding]; other site 481805005512 phosphorylation site [posttranslational modification] 481805005513 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805005514 ATP binding site [chemical binding]; other site 481805005515 Mg2+ binding site [ion binding]; other site 481805005516 G-X-G motif; other site 481805005517 chaperone protein HchA; Provisional; Region: PRK04155 481805005518 Type 1 glutamine amidotransferase (GATase1)-like domain found in Escherichia coli Hsp31 protein (EcHsp31); Region: GATase1_EcHsp31_like; cd03148 481805005519 dimer interface [polypeptide binding]; other site 481805005520 metal binding site [ion binding]; metal-binding site 481805005521 potential oxyanion hole; other site 481805005522 potential catalytic triad [active] 481805005523 conserved cys residue [active] 481805005524 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 481805005525 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 481805005526 eyelet of channel; other site 481805005527 trimer interface [polypeptide binding]; other site 481805005528 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 481805005529 Predicted HD superfamily hydrolase [General function prediction only]; Region: COG1418 481805005530 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481805005531 Zn2+ binding site [ion binding]; other site 481805005532 Mg2+ binding site [ion binding]; other site 481805005533 DNA cytosine methylase; Provisional; Region: PRK10458 481805005534 Cytosine-C5 specific DNA methylases; Methyl transfer reactions play an important role in many aspects of biology. Cytosine-specific DNA methylases are found both in prokaryotes and eukaryotes. DNA methylation, or the covalent addition of a methyl group...; Region: Cyt_C5_DNA_methylase; cd00315 481805005535 cofactor binding site; other site 481805005536 DNA binding site [nucleotide binding] 481805005537 substrate interaction site [chemical binding]; other site 481805005538 Very Short Patch Repair (Vsr) Endonuclease. Endonucleases in DNA repair that recognize damaged DNA and cleave the phosphodiester backbone. Vsr endonucleases have a common endonuclease topology that has been tailored for recognition of TG mismatches; Region: Vsr; cd00221 481805005539 additional DNA contacts [nucleotide binding]; other site 481805005540 mismatch recognition site; other site 481805005541 active site 481805005542 zinc binding site [ion binding]; other site 481805005543 DNA intercalation site [nucleotide binding]; other site 481805005544 putative DMT superfamily transporter inner membrane protein; Provisional; Region: PRK11272 481805005545 EamA-like transporter family; Region: EamA; pfam00892 481805005546 hypothetical protein; Provisional; Region: PRK10062 481805005547 Uncharacterized small protein (DUF2158); Region: DUF2158; cl02293 481805005548 putative diguanylate cyclase YedQ; Provisional; Region: PRK15426 481805005549 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805005550 metal binding site [ion binding]; metal-binding site 481805005551 active site 481805005552 I-site; other site 481805005553 mannosyl-3-phosphoglycerate phosphatase; Reviewed; Region: PRK03669 481805005554 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805005555 active site 481805005556 motif I; other site 481805005557 motif II; other site 481805005558 Protein of unknown function (DUF2525); Region: DUF2525; pfam10733 481805005559 hypothetical protein; Provisional; Region: PRK10708 481805005560 colanic acid capsular biosynthesis activation protein A; Provisional; Region: rcsA; PRK15411 481805005561 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805005562 DNA binding residues [nucleotide binding] 481805005563 dimerization interface [polypeptide binding]; other site 481805005564 flagellar biosynthesis protein FliR; Reviewed; Region: fliR; PRK05701 481805005565 flagellar biosynthesis protein FliQ; Validated; Region: fliQ; PRK05700 481805005566 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 481805005567 flagellar biosynthesis protein FliO; Provisional; Region: PRK11486 481805005568 flagellar motor switch protein FliN; Validated; Region: fliN; PRK07963 481805005569 flagellar motor switch protein; Validated; Region: fliN; PRK05698 481805005570 flagellar motor switch protein FliM; Validated; Region: fliM; PRK06666 481805005571 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 481805005572 flagellar basal body-associated protein FliL; Reviewed; Region: fliL; PRK07021 481805005573 Flagellar hook-length control protein [Cell motility and secretion]; Region: FliK; COG3144 481805005574 flagellar hook-length control protein; Provisional; Region: PRK10118 481805005575 Flagellar biosynthesis chaperone [Cell motility and secretion / Intracellular trafficking and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FliJ; COG2882 481805005576 flagellar biosynthesis chaperone; Validated; Region: fliJ; PRK05689 481805005577 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07960 481805005578 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 481805005579 Walker A motif/ATP binding site; other site 481805005580 Walker B motif; other site 481805005581 flagellar assembly protein H; Validated; Region: fliH; PRK05687 481805005582 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 481805005583 Flagellar assembly protein FliH; Region: FliH; pfam02108 481805005584 flagellar motor switch protein FliG; Region: fliG; TIGR00207 481805005585 FliG C-terminal domain; Region: FliG_C; pfam01706 481805005586 flagellar basal-body M-ring protein/flagellar hook-basal body protein (fliF); Region: fliF; TIGR00206 481805005587 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; pfam01514 481805005588 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 481805005589 flagellar hook-basal body protein FliE; Reviewed; Region: fliE; PRK00253 481805005590 hypothetical protein; Provisional; Region: PRK09951 481805005591 YedF is a bacterial SirA-like protein of unknown function. SirA (also known as UvrY, and YhhP) belongs to a family of a two-component response regulators that controls secondary metabolism and virulence. The other member of this two-component system...; Region: YedF; cd03422 481805005592 CPxP motif; other site 481805005593 putative inner membrane protein; Provisional; Region: PRK11099 481805005594 lipoprotein; Provisional; Region: PRK10397 481805005595 cytoplasmic alpha-amylase; Reviewed; Region: PRK09441 481805005596 Alpha amylase catalytic domain found in bacterial and fungal Alpha amylases (also called 1,4-alpha-D-glucan-4-glucanohydrolase); Region: AmyAc_bac_fung_AmyA; cd11318 481805005597 active site 481805005598 Na/Ca binding site [ion binding]; other site 481805005599 catalytic site [active] 481805005600 flagellar biosynthesis protein FliT; Provisional; Region: PRK10548 481805005601 Flagellar protein FliS; Region: FliS; cl00654 481805005602 flagellar capping protein; Reviewed; Region: fliD; PRK08032 481805005603 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 481805005604 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 481805005605 flagellin; Validated; Region: PRK08026 481805005606 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 481805005607 Flagellin protein; Region: FliC; pfam12445 481805005608 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 481805005609 flagellar biosynthesis sigma factor; Validated; Region: fliA; PRK06986 481805005610 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481805005611 Sigma-70 region 3; Region: Sigma70_r3; pfam04539 481805005612 Sigma70, region (SR) 4 refers to the most C-terminal of four conserved domains found in Escherichia coli (Ec) sigma70, the main housekeeping sigma, and related sigma-factors (SFs). A SF is a dissociable subunit of RNA polymerase, it directs bacterial or...; Region: Sigma70_r4; cd06171 481805005613 DNA binding residues [nucleotide binding] 481805005614 flagella biosynthesis protein FliZ; Provisional; Region: PRK11582 481805005615 cystine transporter subunit; Provisional; Region: PRK11260 481805005616 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805005617 substrate binding pocket [chemical binding]; other site 481805005618 membrane-bound complex binding site; other site 481805005619 hinge residues; other site 481805005620 D-cysteine desulfhydrase; Validated; Region: PRK03910 481805005621 Aminocyclopropane-1-carboxylate deaminase (ACCD): Pyridoxal phosphate (PLP)-dependent enzyme which catalyzes the conversion of 1-aminocyclopropane-L-carboxylate (ACC), a precursor of the plant hormone ethylene, to alpha-ketobutyrate and ammonia; Region: ACCD; cd06449 481805005622 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805005623 catalytic residue [active] 481805005624 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 481805005625 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805005626 dimer interface [polypeptide binding]; other site 481805005627 conserved gate region; other site 481805005628 putative PBP binding loops; other site 481805005629 ABC-ATPase subunit interface; other site 481805005630 putative amino-acid ABC transporter ATP-binding protein YecC; Provisional; Region: PRK11264 481805005631 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 481805005632 Walker A/P-loop; other site 481805005633 ATP binding site [chemical binding]; other site 481805005634 Q-loop/lid; other site 481805005635 ABC transporter signature motif; other site 481805005636 Walker B; other site 481805005637 D-loop; other site 481805005638 H-loop/switch region; other site 481805005639 DNA-binding transcriptional activator SdiA; Provisional; Region: PRK10188 481805005640 Autoinducer binding domain; Region: Autoind_bind; pfam03472 481805005641 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805005642 DNA binding residues [nucleotide binding] 481805005643 dimerization interface [polypeptide binding]; other site 481805005644 hypothetical protein; Provisional; Region: PRK10613 481805005645 response regulator; Provisional; Region: PRK09483 481805005646 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805005647 active site 481805005648 phosphorylation site [posttranslational modification] 481805005649 intermolecular recognition site; other site 481805005650 dimerization interface [polypeptide binding]; other site 481805005651 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805005652 DNA binding residues [nucleotide binding] 481805005653 dimerization interface [polypeptide binding]; other site 481805005654 excinuclease ABC subunit C; Validated; Region: uvrC; PRK00558 481805005655 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 481805005656 GIY-YIG motif/motif A; other site 481805005657 active site 481805005658 catalytic site [active] 481805005659 putative DNA binding site [nucleotide binding]; other site 481805005660 metal binding site [ion binding]; metal-binding site 481805005661 UvrB/uvrC motif; Region: UVR; pfam02151 481805005662 UvrC Helix-hairpin-helix N-terminal; Region: UvrC_HhH_N; pfam08459 481805005663 Helix-hairpin-helix motif; Region: HHH; pfam00633 481805005664 phosphatidylglycerophosphate synthetase; Provisional; Region: PRK10832 481805005665 hypothetical protein; Provisional; Region: PRK10396 481805005666 yecA family protein; Region: ygfB_yecA; TIGR02292 481805005667 SEC-C motif; Region: SEC-C; pfam02810 481805005668 tyrosine transporter TyrP; Provisional; Region: PRK15132 481805005669 aromatic amino acid transport protein; Region: araaP; TIGR00837 481805005670 probable metal-binding protein; Region: matur_matur; TIGR03853 481805005671 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 481805005672 Ferritin-like domain; Region: Ferritin; pfam00210 481805005673 ferroxidase diiron center [ion binding]; other site 481805005674 YecR-like lipoprotein; Region: YecR; pfam13992 481805005675 nonheme-containing ferritins; Region: Nonheme_Ferritin; cd01055 481805005676 Ferritin-like domain; Region: Ferritin; pfam00210 481805005677 ferroxidase diiron center [ion binding]; other site 481805005678 Periplasmic binding proteins and sugar binding domain of LacI family; Region: Peripla_BP_1; pfam00532 481805005679 Periplasmic L-arabinose-binding protein (ABP), a member of a family of pentose/hexose sugar-binding proteins of the type I periplasmic binding protein superfamily; Region: PBP1_arabinose_binding; cd01540 481805005680 ligand binding site [chemical binding]; other site 481805005681 L-arabinose transporter ATP-binding protein; Provisional; Region: araG; PRK11288 481805005682 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 481805005683 Walker A/P-loop; other site 481805005684 ATP binding site [chemical binding]; other site 481805005685 Q-loop/lid; other site 481805005686 ABC transporter signature motif; other site 481805005687 Walker B; other site 481805005688 D-loop; other site 481805005689 H-loop/switch region; other site 481805005690 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481805005691 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481805005692 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481805005693 TM-ABC transporter signature motif; other site 481805005694 trehalose-6-phosphate phosphatase; Provisional; Region: PRK10187 481805005695 Trehalose-6-phosphatase [Carbohydrate transport and metabolism]; Region: OtsB; COG1877 481805005696 alpha,alpha-trehalose-phosphate synthase [UDP-forming]; Region: trehalose_OtsA; TIGR02400 481805005697 Trehalose-6-Phosphate Synthase (TPS) is a glycosyltransferase that catalyses the synthesis of alpha,alpha-1,1-trehalose-6-phosphate from glucose-6-phosphate using a UDP-glucose donor. It is a key enzyme in the trehalose synthesis pathway. Trehalose is a...; Region: GT1_TPS; cd03788 481805005698 active site 481805005699 homotetramer interface [polypeptide binding]; other site 481805005700 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 481805005701 Ligand Binding Site [chemical binding]; other site 481805005702 transcriptional activator FlhD; Provisional; Region: PRK02909 481805005703 transcriptional activator FlhC; Provisional; Region: PRK12722 481805005704 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 481805005705 flagellar motor protein MotA; Validated; Region: PRK09110 481805005706 flagellar motor protein MotB; Validated; Region: motB; PRK09041 481805005707 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 481805005708 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 481805005709 ligand binding site [chemical binding]; other site 481805005710 chemotaxis protein CheA; Provisional; Region: PRK10547 481805005711 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 481805005712 putative binding surface; other site 481805005713 active site 481805005714 CheY binding; Region: CheY-binding; pfam09078 481805005715 Signal transducing histidine kinase, homodimeric domain; Region: H-kinase_dim; pfam02895 481805005716 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805005717 ATP binding site [chemical binding]; other site 481805005718 Mg2+ binding site [ion binding]; other site 481805005719 G-X-G motif; other site 481805005720 CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis receptor a histidine phosphoryl group from CheA is passed directly to an aspartate in the response regulator CheY. This signalling...; Region: CheA_reg; cd00731 481805005721 CheW, a small regulator protein, unique to the chemotaxis signalling in prokaryotes and archea. CheW interacts with the histidine kinase CheA, most likely with the related regulatory domain of CheA. CheW is proposed to form signalling arrays together...; Region: CheW; cd00732 481805005722 putative CheA interaction surface; other site 481805005723 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 481805005724 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 481805005725 dimer interface [polypeptide binding]; other site 481805005726 ligand binding site [chemical binding]; other site 481805005727 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805005728 dimerization interface [polypeptide binding]; other site 481805005729 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481805005730 dimer interface [polypeptide binding]; other site 481805005731 putative CheW interface [polypeptide binding]; other site 481805005732 methyl-accepting protein IV; Provisional; Region: PRK09793 481805005733 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 481805005734 dimer interface [polypeptide binding]; other site 481805005735 ligand binding site [chemical binding]; other site 481805005736 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805005737 dimerization interface [polypeptide binding]; other site 481805005738 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481805005739 dimer interface [polypeptide binding]; other site 481805005740 putative CheW interface [polypeptide binding]; other site 481805005741 chemotaxis methyltransferase CheR; Provisional; Region: PRK10611 481805005742 CheR methyltransferase, all-alpha domain; Region: CheR_N; pfam03705 481805005743 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805005744 S-adenosylmethionine binding site [chemical binding]; other site 481805005745 chemotaxis-specific methylesterase; Provisional; Region: PRK00742 481805005746 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805005747 active site 481805005748 phosphorylation site [posttranslational modification] 481805005749 intermolecular recognition site; other site 481805005750 dimerization interface [polypeptide binding]; other site 481805005751 CheB methylesterase; Region: CheB_methylest; pfam01339 481805005752 chemotaxis regulatory protein CheY; Provisional; Region: PRK10610 481805005753 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805005754 active site 481805005755 phosphorylation site [posttranslational modification] 481805005756 intermolecular recognition site; other site 481805005757 dimerization interface [polypeptide binding]; other site 481805005758 chemotaxis regulator CheZ; Provisional; Region: PRK11166 481805005759 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 481805005760 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257 481805005761 flagellar biosynthesis protein FlhA; Validated; Region: flhA; PRK06012 481805005762 FHIPEP family; Region: FHIPEP; pfam00771 481805005763 Flagellar protein FlhE; Region: FlhE; pfam06366 481805005764 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3755 481805005765 Arginyl tRNA synthetase N terminal dom; Region: Arg_tRNA_synt_N; smart01016 481805005766 arginyl-tRNA synthetase; Region: argS; TIGR00456 481805005767 catalytic core domain of arginyl-tRNA synthetases; Region: ArgRS_core; cd00671 481805005768 active site 481805005769 HIGH motif; other site 481805005770 KMSK motif region; other site 481805005771 Anticodon-binding domain of arginyl tRNA synthetases; Region: Anticodon_Ia_Arg; cd07956 481805005772 tRNA binding surface [nucleotide binding]; other site 481805005773 anticodon binding site; other site 481805005774 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_4; cd07268 481805005775 putative metal binding site [ion binding]; other site 481805005776 copper homeostasis protein CutC; Provisional; Region: PRK11572 481805005777 trimethylamine-N-oxide reductase c-type cytochrome TorC; Region: torC; TIGR02162 481805005778 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 481805005779 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 481805005780 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 481805005781 molybdopterin guanine dinucleotide-containing S/N-oxide reductases; Region: bisC_fam; TIGR00509 481805005782 molybdopterin cofactor binding site [chemical binding]; other site 481805005783 substrate binding site [chemical binding]; other site 481805005784 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 481805005785 molybdopterin cofactor binding site; other site 481805005786 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805005787 S-adenosylmethionine binding site [chemical binding]; other site 481805005788 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805005789 S-adenosylmethionine binding site [chemical binding]; other site 481805005790 Uncharacterized relative of glutathione S-transferase, MAPEG superfamily [General function prediction only]; Region: COG3788 481805005791 hypothetical protein; Provisional; Region: PRK10302 481805005792 Isochorismatase family; Region: Isochorismatase; pfam00857 481805005793 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 481805005794 catalytic triad [active] 481805005795 conserved cis-peptide bond; other site 481805005796 aspartyl-tRNA synthetase; Validated; Region: aspS; PRK00476 481805005797 EcAspRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli aspartyl-tRNA synthetase (AspRS), the human mitochondrial (mt) AspRS-2, the discriminating (D) Thermus thermophilus AspRS-1, and the nondiscriminating (ND)...; Region: EcAspRS_like_N; cd04317 481805005798 dimer interface [polypeptide binding]; other site 481805005799 anticodon binding site; other site 481805005800 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 481805005801 homodimer interface [polypeptide binding]; other site 481805005802 motif 1; other site 481805005803 active site 481805005804 motif 2; other site 481805005805 GAD domain; Region: GAD; pfam02938 481805005806 Asp tRNA synthetase (aspRS) class II core domain. Class II assignment is based upon its structure and the presence of three characteristic sequence motifs. AspRS is a homodimer, which attaches a specific amino acid to the 3' OH group of ribose of...; Region: AspRS_core; cd00777 481805005807 motif 3; other site 481805005808 Members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes belonging to this superfamily require a divalent cation, such as Mg2+ or Mn2+, for their activity and contain a highly...; Region: Nudix_Hydrolase_7; cd04664 481805005809 nudix motif; other site 481805005810 hypothetical protein; Validated; Region: PRK00110 481805005811 Holliday junction resolvases (HJRs) are endonucleases that specifically resolve Holliday junction DNA intermediates during homologous recombination. HJR's occur in archaea, bacteria, and in the mitochondria of certain fungi, however this CD...; Region: RuvC_resolvase; cd00529 481805005812 active site 481805005813 putative DNA-binding cleft [nucleotide binding]; other site 481805005814 dimer interface [polypeptide binding]; other site 481805005815 hypothetical protein; Provisional; Region: PRK11470 481805005816 Holliday junction DNA helicase RuvA; Reviewed; Region: ruvA; PRK00116 481805005817 RuvA N terminal domain; Region: RuvA_N; pfam01330 481805005818 RuvA, C-terminal domain; Region: RuvA_C; pfam07499 481805005819 Holliday junction DNA helicase RuvB; Reviewed; Region: ruvB; PRK00080 481805005820 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805005821 Walker A motif; other site 481805005822 ATP binding site [chemical binding]; other site 481805005823 Walker B motif; other site 481805005824 arginine finger; other site 481805005825 Holliday junction DNA helicase ruvB C-terminus; Region: RuvB_C; pfam05491 481805005826 ABC-type Mn2+/Zn2+ transport systems, permease components [Inorganic ion transport and metabolism]; Region: ZnuB; COG1108 481805005827 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481805005828 ABC-ATPase subunit interface; other site 481805005829 dimer interface [polypeptide binding]; other site 481805005830 putative PBP binding regions; other site 481805005831 high-affinity zinc transporter ATPase; Reviewed; Region: znuC; PRK09544 481805005832 ATP-binding cassette domain of the metal-type transporters; Region: ABC_Metallic_Cations; cd03235 481805005833 high-affinity zinc transporter periplasmic component; Reviewed; Region: znuA; PRK09545 481805005834 Zinc binding protein ZnuA. These proteins have been shown to function as initial receptors in the ABC uptake of Zn2+. They belong to the TroA superfamily of periplasmic metal binding proteins that share a distinct fold and ligand binding mechanism; Region: ZnuA; cd01019 481805005835 metal binding site [ion binding]; metal-binding site 481805005836 putative peptidase; Provisional; Region: PRK11649 481805005837 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 481805005838 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481805005839 Peptidase family M23; Region: Peptidase_M23; pfam01551 481805005840 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 481805005841 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 481805005842 putative acyl-acceptor binding pocket; other site 481805005843 pyruvate kinase; Provisional; Region: PRK05826 481805005844 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 481805005845 domain interfaces; other site 481805005846 active site 481805005847 DNA-binding transcriptional regulator HexR; Provisional; Region: PRK11302 481805005848 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 481805005849 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 481805005850 putative active site [active] 481805005851 glucose-6-phosphate 1-dehydrogenase; Validated; Region: PRK05722 481805005852 Glucose-6-phosphate dehydrogenase, NAD binding domain; Region: G6PD_N; pfam00479 481805005853 Glucose-6-phosphate dehydrogenase, C-terminal domain; Region: G6PD_C; pfam02781 481805005854 phosphogluconate dehydratase; Validated; Region: PRK09054 481805005855 6-phosphogluconate dehydratase; Region: edd; TIGR01196 481805005856 keto-hydroxyglutarate-aldolase/keto-deoxy- phosphogluconate aldolase; Provisional; Region: PRK05718 481805005857 KDPG and KHG aldolase; Region: KDPG_aldolase; cd00452 481805005858 active site 481805005859 intersubunit interface [polypeptide binding]; other site 481805005860 catalytic residue [active] 481805005861 phosphoribosylglycinamide formyltransferase 2; Validated; Region: purT; PRK09288 481805005862 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481805005863 ATP-grasp domain; Region: ATP-grasp; pfam02222 481805005864 DNA damage-inducible protein YebG; Provisional; Region: PRK10061 481805005865 hypothetical protein; Provisional; Region: PRK13680 481805005866 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2979 481805005867 tellurium resistance terB-like protein, subgroup 3; Region: terB_like_YebE; cd07178 481805005868 putative metal binding site [ion binding]; other site 481805005869 protease 2; Provisional; Region: PRK10115 481805005870 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481805005871 exodeoxyribonuclease X; Provisional; Region: PRK07983 481805005872 DEDDh 3'-5' exonuclease domain family; Region: DEDDh; cd06127 481805005873 active site 481805005874 catalytic site [active] 481805005875 substrate binding site [chemical binding]; other site 481805005876 Predicted amidohydrolase [General function prediction only]; Region: COG0388 481805005877 Carbon-nitrogen hydrolase; Region: CN_hydrolase; pfam00795 481805005878 DNA polymerase III subunit theta; Reviewed; Region: PRK10969 481805005879 hypothetical protein; Provisional; Region: PRK10301 481805005880 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 481805005881 Protein of unknown function (DUF2511); Region: DUF2511; pfam10709 481805005882 serine/threonine protein phosphatase 1; Provisional; Region: pphA; PRK11439 481805005883 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481805005884 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 481805005885 Protein of unknown function (DUF1480); Region: DUF1480; pfam07351 481805005886 rRNA (cytosine-C(5)-)-methyltransferase RsmF; Reviewed; Region: yebU; PRK11933 481805005887 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805005888 S-adenosylmethionine binding site [chemical binding]; other site 481805005889 pre-rRNA processing and ribosome biogenesis; Region: Nol1_Nop2_Fmu_2; pfam13636 481805005890 Paraquat-inducible protein B [General function prediction only]; Region: PqiB; COG3008 481805005891 mce related protein; Region: MCE; pfam02470 481805005892 mce related protein; Region: MCE; pfam02470 481805005893 mce related protein; Region: MCE; pfam02470 481805005894 mce related protein; Region: MCE; pfam02470 481805005895 mce related protein; Region: MCE; pfam02470 481805005896 integral membrane protein, PqiA family; Region: pqiA_fam; TIGR00155 481805005897 Paraquat-inducible protein A; Region: PqiA; pfam04403 481805005898 Paraquat-inducible protein A; Region: PqiA; pfam04403 481805005899 GAF domain-containing protein [Signal transduction mechanisms]; Region: COG1956 481805005900 GAF domain; Region: GAF_2; pfam13185 481805005901 ProP expression regulator; Provisional; Region: PRK04950 481805005902 ProQ/FINO family; Region: ProQ; pfam04352 481805005903 carboxy-terminal protease; Provisional; Region: PRK11186 481805005904 PDZ domain of C-terminal processing-, tail-specific-, and tricorn proteases, which function in posttranslational protein processing, maturation, and disassembly or degradation, in Bacteria, Archaea, and plant chloroplasts. May be responsible for...; Region: PDZ_CTP_protease; cd00988 481805005905 protein binding site [polypeptide binding]; other site 481805005906 C-terminal processing peptidase; serine protease family S41; Region: Peptidase_S41_CPP; cd07560 481805005907 Catalytic dyad [active] 481805005908 C-terminal domain of tail specific protease (DUF3340); Region: DUF3340; pfam11818 481805005909 heat shock protein HtpX; Provisional; Region: PRK05457 481805005910 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805005911 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481805005912 putative substrate translocation pore; other site 481805005913 Predicted integral membrane protein [Function unknown]; Region: COG5521 481805005914 DNA-binding transcriptional regulator KdgR; Provisional; Region: PRK15090 481805005915 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481805005916 dimerization interface [polypeptide binding]; other site 481805005917 putative Zn2+ binding site [ion binding]; other site 481805005918 putative DNA binding site [nucleotide binding]; other site 481805005919 Bacterial transcriptional regulator; Region: IclR; pfam01614 481805005920 YobH-like protein; Region: YobH; pfam13996 481805005921 PhoPQ regulatory protein; Provisional; Region: PRK10299 481805005922 YebO-like protein; Region: YebO; pfam13974 481805005923 23S rRNA methyltransferase A; Provisional; Region: rrmA; PRK11088 481805005924 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805005925 S-adenosylmethionine binding site [chemical binding]; other site 481805005926 hypothetical protein; Provisional; Region: PRK11469 481805005927 Domain of unknown function DUF; Region: DUF204; pfam02659 481805005928 Domain of unknown function DUF; Region: DUF204; pfam02659 481805005929 Predicted membrane protein [Function unknown]; Region: COG4811 481805005930 PTS system mannose-specific transporter subunit IID; Provisional; Region: PRK11103 481805005931 PTS system mannose-specific transporter subunit IIC; Provisional; Region: PRK15065 481805005932 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805005933 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805005934 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805005935 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805005936 Membrane protein TerC, possibly involved in tellurium resistance [Inorganic ion transport and metabolism]; Region: TerC; COG0861 481805005937 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 481805005938 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 481805005939 Transporter associated domain; Region: CorC_HlyC; smart01091 481805005940 phage resistance protein; Provisional; Region: PRK10551 481805005941 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 481805005942 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805005943 L-serine deaminase; Provisional; Region: PRK15023 481805005944 Serine dehydratase beta chain; Region: SDH_beta; pfam03315 481805005945 Serine dehydratase alpha chain; Region: SDH_alpha; pfam03313 481805005946 Coenzyme A pyrophosphatase (CoAse), a member of the Nudix hydrolase superfamily, functions to catalyze the elimination of oxidized inactive CoA, which can inhibit CoA-utilizing enzymes. The need of CoAses mainly arises under conditions of oxidative...; Region: CoAse; cd03426 481805005947 putative active site [active] 481805005948 putative CoA binding site [chemical binding]; other site 481805005949 nudix motif; other site 481805005950 metal binding site [ion binding]; metal-binding site 481805005951 aminodeoxychorismate synthase subunit I; Provisional; Region: pabB; PRK15465 481805005952 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 481805005953 aminodeoxychorismate synthase, component I, bacterial clade; Region: pabB; TIGR00553 481805005954 hypothetical protein; Provisional; Region: PRK05114 481805005955 Domain of unknown function (DUF1889); Region: DUF1889; pfam08986 481805005956 This group of proteins belong to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence...; Region: YjgF_YER057c_UK114_like_2; cd06150 481805005957 homotrimer interaction site [polypeptide binding]; other site 481805005958 putative active site [active] 481805005959 Rad3-related DNA helicases [Transcription / DNA replication, recombination, and repair]; Region: DinG; COG1199 481805005960 DEAD/DEAH box helicase; Region: DEAD; pfam00270 481805005961 DEAD_2; Region: DEAD_2; pfam06733 481805005962 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 481805005963 Inactive homolog of metal-dependent proteases, putative molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: COG1214 481805005964 Glycoprotease family; Region: Peptidase_M22; pfam00814 481805005965 Outer membrane lipoprotein Slp family; Region: Slp; cl01164 481805005966 long-chain-fatty-acid--CoA ligase; Validated; Region: PRK08974 481805005967 Prokaryotic long-chain fatty acid CoA synthetases similar to Escherichia coli FadD; Region: FC-FACS_FadD_like; cd05936 481805005968 acyl-activating enzyme (AAE) consensus motif; other site 481805005969 putative AMP binding site [chemical binding]; other site 481805005970 putative active site [active] 481805005971 putative CoA binding site [chemical binding]; other site 481805005972 ribonuclease D; Provisional; Region: PRK10829 481805005973 DEDDy 3'-5' exonuclease domain of Ribonuclease D and similar proteins; Region: RNaseD_exo; cd06142 481805005974 catalytic site [active] 481805005975 putative active site [active] 481805005976 putative substrate binding site [chemical binding]; other site 481805005977 Helicase and RNase D C-terminal; Region: HRDC; smart00341 481805005978 Flavodoxin reductases (ferredoxin-NADPH reductases) family 1 [Energy production and conversion]; Region: Hmp; COG1018 481805005979 Phthalate dioxygenase reductase (PDR) is an FMN-dependent reductase that mediates electron transfer from NADH to FMN to an iron sulfur cluster. PDR has an an N-terminal ferrredoxin reductase (FNR)-like NAD(H) binding domain and a C-terminal iron-sulfur; Region: PDR_like; cd06185 481805005980 FMN-binding pocket [chemical binding]; other site 481805005981 flavin binding motif; other site 481805005982 phosphate binding motif [ion binding]; other site 481805005983 beta-alpha-beta structure motif; other site 481805005984 NAD binding pocket [chemical binding]; other site 481805005985 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 481805005986 catalytic loop [active] 481805005987 iron binding site [ion binding]; other site 481805005988 Phenylpropionate dioxygenase and related ring-hydroxylating dioxygenases, large terminal subunit [Inorganic ion transport and metabolism / General function prediction only]; Region: HcaE; COG4638 481805005989 Rieske non-heme iron oxygenase (RO) family, N-terminal Rieske domain of the oxygenase alpha subunit; The RO family comprise a large class of aromatic ring-hydroxylating dioxygenases found predominantly in microorganisms. These enzymes enable...; Region: Rieske_RO_Alpha_N; cd03469 481805005990 [2Fe-2S] cluster binding site [ion binding]; other site 481805005991 C-terminal catalytic domain of the oxygenase alpha subunit of an uncharacterized subgroup of Rieske-type non-heme iron aromatic ring-hydroxylating oxygenases; Region: RHO_alpha_C_2; cd08886 481805005992 putative alpha subunit interface [polypeptide binding]; other site 481805005993 putative active site [active] 481805005994 putative substrate binding site [chemical binding]; other site 481805005995 Fe binding site [ion binding]; other site 481805005996 putative transporter; Provisional; Region: PRK09950 481805005997 Isocitrate/isopropylmalate dehydrogenase [Amino acid transport and metabolism]; Region: LeuB; COG0473 481805005998 tartrate dehydrogenase; Region: TTC; TIGR02089 481805005999 transcriptional activator TtdR; Provisional; Region: PRK09801 481805006000 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805006001 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_9; cd08479 481805006002 putative effector binding pocket; other site 481805006003 putative dimerization interface [polypeptide binding]; other site 481805006004 leucine export protein LeuE; Provisional; Region: PRK10958 481805006005 Uncharacterized protein/domain, possibly involved in tellurite resistance [Inorganic ion transport and metabolism]; Region: TehB; COG3615 481805006006 Domain of unknown function (DUF1869); Region: DUF1869; pfam08956 481805006007 hypothetical protein; Provisional; Region: PRK10457 481805006008 FOG: GAF domain [Signal transduction mechanisms]; Region: FhlA; COG2203 481805006009 Domain present in phytochromes and cGMP-specific phosphodiesterases; Region: GAF; smart00065 481805006010 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481805006011 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805006012 metal binding site [ion binding]; metal-binding site 481805006013 active site 481805006014 I-site; other site 481805006015 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 481805006016 Domain of unknown function (DUF333); Region: DUF333; pfam03891 481805006017 Uncharacterized conserved protein [Function unknown]; Region: COG3189 481805006018 cyanate transporter; Region: CynX; TIGR00896 481805006019 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805006020 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481805006021 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805006022 Predicted membrane protein [Function unknown]; Region: COG2707 481805006023 YeaK is an uncharacterized Echerichia coli protein with a YbaK-like domain of unknown function. The YbaK-like domain family includes the INS amino acid-editing domain of the bacterial class II prolyl tRNA synthetase (ProRS), and it's trans-acting...; Region: YeaK; cd04336 481805006024 putative deacylase active site [active] 481805006025 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481805006026 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805006027 metal binding site [ion binding]; metal-binding site 481805006028 active site 481805006029 I-site; other site 481805006030 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481805006031 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805006032 metal binding site [ion binding]; metal-binding site 481805006033 active site 481805006034 I-site; other site 481805006035 hypothetical protein; Provisional; Region: PRK05325 481805006036 PrkA family serine protein kinase; Provisional; Region: PRK15455 481805006037 AAA ATPase domain; Region: AAA_16; pfam13191 481805006038 PrkA serine protein kinase C-terminal domain; Region: PrkA; pfam06798 481805006039 Outer membrane protein V [Cell envelope biogenesis, outer membrane]; Region: OmpV; COG3713 481805006040 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481805006041 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481805006042 active site 481805006043 catalytic tetrad [active] 481805006044 D-hexose-6-phosphate epimerase-like; Region: D-hex-6-P-epi_like; cd09020 481805006045 active site 481805006046 phosphate binding residues; other site 481805006047 catalytic residues [active] 481805006048 glyceraldehyde-3-phosphate dehydrogenase A; Provisional; Region: gapA; PRK15425 481805006049 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 481805006050 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 481805006051 methionine sulfoxide reductase B; Provisional; Region: PRK00222 481805006052 SelR domain; Region: SelR; pfam01641 481805006053 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3139 481805006054 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 481805006055 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH4; cd08258 481805006056 putative NAD(P) binding site [chemical binding]; other site 481805006057 catalytic Zn binding site [ion binding]; other site 481805006058 structural Zn binding site [ion binding]; other site 481805006059 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805006060 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805006061 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 481805006062 Sorbitol dehydrogenase; Region: sorbitol_DH; cd05285 481805006063 inhibitor binding site; inhibition site 481805006064 catalytic Zn binding site [ion binding]; other site 481805006065 structural Zn binding site [ion binding]; other site 481805006066 NADP binding site [chemical binding]; other site 481805006067 tetramer interface [polypeptide binding]; other site 481805006068 Tagatose-1,6-bisphosphate (TBP) aldolase and related Type B Class II aldolases. TBP aldolase is a tetrameric class II aldolase that catalyzes the reversible condensation of dihydroxyacetone phosphate with glyceraldehyde 3-phsophate to produce tagatose 1; Region: TBP_aldolase_IIB; cd00947 481805006069 intersubunit interface [polypeptide binding]; other site 481805006070 active site 481805006071 zinc binding site [ion binding]; other site 481805006072 Na+ binding site [ion binding]; other site 481805006073 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 481805006074 2-keto-3-deoxygluconate kinase (KdgK) phosphorylates 2-keto-3-deoxygluconate (KDG) to form 2-keto-3-deoxy-6-phosphogluconate (KDGP). KDG is the common intermediate product, that allows organisms to channel D-glucuronate and/or D-galacturinate into the...; Region: KdgK; cd01166 481805006075 substrate binding site [chemical binding]; other site 481805006076 ATP binding site [chemical binding]; other site 481805006077 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 481805006078 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 481805006079 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481805006080 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 481805006081 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805006082 putative substrate translocation pore; other site 481805006083 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805006084 Nicotinamidase/pyrazinamidase (PZase). Nicotinamidase, a ubiquitous enzyme in prokaryotes, converts nicotinamide to nicotinic acid (niacin) and ammonia, which in turn can be recycled to make nicotinamide adenine dinucleotide (NAD). The same enzyme is...; Region: nicotinamidase; cd01011 481805006085 Isochorismatase family; Region: Isochorismatase; pfam00857 481805006086 catalytic triad [active] 481805006087 metal binding site [ion binding]; metal-binding site 481805006088 conserved cis-peptide bond; other site 481805006089 Type I (cytosolic) bacterial L-asparaginase; Region: L-asparaginase_I; cd08963 481805006090 active site 481805006091 homodimer interface [polypeptide binding]; other site 481805006092 protease 4; Provisional; Region: PRK10949 481805006093 Signal peptide peptidase A (SppA) 67K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_67K_type; cd07018 481805006094 tandem repeat interface [polypeptide binding]; other site 481805006095 oligomer interface [polypeptide binding]; other site 481805006096 active site residues [active] 481805006097 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_SppA_1; cd07019 481805006098 tandem repeat interface [polypeptide binding]; other site 481805006099 oligomer interface [polypeptide binding]; other site 481805006100 active site residues [active] 481805006101 Nitroreductase-like family which includes NADH oxidase and arsenite oxidiase. NADH oxidase catalyses the oxidation of NAD(P)H and accepts a wide broad range of compounds as electron acceptors, such as nitrocompound. Arsenite oxidase in a...; Region: Arsenite_oxidase; cd02135 481805006102 putative FMN binding site [chemical binding]; other site 481805006103 selenophosphate synthetase; Provisional; Region: PRK00943 481805006104 Selenophosphate synthetase (SelD) catalyzes the conversion of selenium to selenophosphate which is required by a number of bacterial, archaeal and eukaryotic organisms for synthesis of Secys-tRNA, the precursor of selenocysteine in selenoenzymes. The...; Region: SelD; cd02195 481805006105 dimerization interface [polypeptide binding]; other site 481805006106 putative ATP binding site [chemical binding]; other site 481805006107 DNA topoisomerase III; Provisional; Region: PRK07726 481805006108 TOPRIM_TopoIA_TopoIII: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to topoisomerase III. Type IA DNA topoisomerases remove (relax) negative supercoils in the DNA by: cleaving...; Region: TOPRIM_TopoIA_TopoIII; cd03362 481805006109 active site 481805006110 putative interdomain interaction site [polypeptide binding]; other site 481805006111 putative metal-binding site [ion binding]; other site 481805006112 putative nucleotide binding site [chemical binding]; other site 481805006113 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 481805006114 domain I; other site 481805006115 DNA binding groove [nucleotide binding] 481805006116 phosphate binding site [ion binding]; other site 481805006117 domain II; other site 481805006118 domain III; other site 481805006119 nucleotide binding site [chemical binding]; other site 481805006120 catalytic site [active] 481805006121 domain IV; other site 481805006122 hypothetical protein; Provisional; Region: PRK11380 481805006123 glutamate dehydrogenase; Provisional; Region: PRK09414 481805006124 Glu/Leu/Phe/Val dehydrogenase, dimerisation domain; Region: ELFV_dehydrog_N; pfam02812 481805006125 NAD(P) binding domain of glutamate dehydrogenase, subgroup 2; Region: NAD_bind_2_Glu_DH; cd05313 481805006126 NAD(P) binding site [chemical binding]; other site 481805006127 Protein of unknown function (DUF1496); Region: DUF1496; pfam07383 481805006128 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 481805006129 active site 481805006130 8-oxo-dGMP binding site [chemical binding]; other site 481805006131 nudix motif; other site 481805006132 metal binding site [ion binding]; metal-binding site 481805006133 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 481805006134 Rhodanese Homology Domain; Region: RHOD; smart00450 481805006135 Rhodanese-related sulfurtransferase [Inorganic ion transport and metabolism]; Region: SseA; COG2897 481805006136 Thiosulfate sulfurtransferase (TST), N-terminal, inactive domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the 1st repeat, which does not contain the catalytically active Cys residue. The role of the 1st repeat is uncertain, but it...; Region: TST_Repeat_1; cd01448 481805006137 active site residue [active] 481805006138 Thiosulfate sulfurtransferase (TST), C-terminal, catalytic domain. TST contains 2 copies of the Rhodanese Homology Domain; this is the second repeat. Only the second repeat contains the catalytically active Cys residue; Region: TST_Repeat_2; cd01449 481805006139 active site residue [active] 481805006140 ABC-type uncharacterized transport system, ATPase component [General function prediction only]; Region: COG4136 481805006141 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805006142 Walker A/P-loop; other site 481805006143 ATP binding site [chemical binding]; other site 481805006144 Q-loop/lid; other site 481805006145 ABC transporter signature motif; other site 481805006146 Walker B; other site 481805006147 D-loop; other site 481805006148 H-loop/switch region; other site 481805006149 ABC-type uncharacterized transport system, permease component [General function prediction only]; Region: COG4135 481805006150 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805006151 dimer interface [polypeptide binding]; other site 481805006152 conserved gate region; other site 481805006153 putative PBP binding loops; other site 481805006154 ABC-ATPase subunit interface; other site 481805006155 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4134 481805006156 hypothetical protein; Provisional; Region: PRK11622 481805006157 Uncharacterized conserved protein [Function unknown]; Region: COG2128 481805006158 Carboxymuconolactone decarboxylase family; Region: CMD; pfam02627 481805006159 Uncharacterized conserved protein [Function unknown]; Region: COG0398 481805006160 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 481805006161 Uncharacterized conserved protein [Function unknown]; Region: COG0398 481805006162 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 481805006163 Escherichia coli exonuclease III (ExoIII) and Neisseria meningitides NExo-like subfamily of the ExoIII family purinic/apyrimidinic (AP) endonucleases; Region: ExoIII-like_AP-endo; cd09086 481805006164 putative catalytic site [active] 481805006165 putative phosphate binding site [ion binding]; other site 481805006166 active site 481805006167 metal binding site A [ion binding]; metal-binding site 481805006168 DNA binding site [nucleotide binding] 481805006169 putative AP binding site [nucleotide binding]; other site 481805006170 putative metal binding site B [ion binding]; other site 481805006171 bifunctional succinylornithine transaminase/acetylornithine transaminase; Provisional; Region: PRK12381 481805006172 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 481805006173 inhibitor-cofactor binding pocket; inhibition site 481805006174 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805006175 catalytic residue [active] 481805006176 arginine succinyltransferase; Provisional; Region: PRK10456 481805006177 Arginine/ornithine N-succinyltransferase beta subunit [Amino acid transport and metabolism]; Region: AstA; COG3138 481805006178 succinylglutamic semialdehyde dehydrogenase; Reviewed; Region: astD; PRK09457 481805006179 N-succinylglutamate 5-semialdehyde dehydrogenase, AstD-like; Region: ALDH_SGSD_AstD; cd07095 481805006180 NAD(P) binding site [chemical binding]; other site 481805006181 catalytic residues [active] 481805006182 succinylarginine dihydrolase; Provisional; Region: PRK13281 481805006183 Peptidase M14 Succinylglutamate desuccinylase (ASTE) subfamily; Region: M14_ASTE; cd03855 481805006184 Succinylglutamate desuccinylase / Aspartoacylase family; Region: AstE_AspA; pfam04952 481805006185 putative active site [active] 481805006186 Zn binding site [ion binding]; other site 481805006187 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 481805006188 dimer interface [polypeptide binding]; other site 481805006189 hypothetical protein; Provisional; Region: PRK11396 481805006190 nucleotide excision repair endonuclease; Provisional; Region: PRK10545 481805006191 Catalytic GIY-YIG domain of nucleotide excision repair endonucleases UvrC, Cho, and similar proteins; Region: GIY-YIG_UvrC_Cho; cd10434 481805006192 GIY-YIG motif/motif A; other site 481805006193 active site 481805006194 catalytic site [active] 481805006195 putative DNA binding site [nucleotide binding]; other site 481805006196 metal binding site [ion binding]; metal-binding site 481805006197 NAD+ synthetase; Region: nadE; TIGR00552 481805006198 NAD+ synthase is a homodimer, which catalyzes the final step in de novo nicotinamide adenine dinucleotide (NAD+) biosynthesis, an amide transfer from either ammonia or glutamine to nicotinic acid adenine dinucleotide (NaAD). The conversion of NaAD to NAD...; Region: NAD_synthase; cd00553 481805006199 homodimer interface [polypeptide binding]; other site 481805006200 NAD binding pocket [chemical binding]; other site 481805006201 ATP binding pocket [chemical binding]; other site 481805006202 Mg binding site [ion binding]; other site 481805006203 active-site loop [active] 481805006204 DNA-binding transcriptional activator OsmE; Provisional; Region: PRK11251 481805006205 PTS_IIB_chitobiose_lichenan: subunit IIB of enzyme II (EII) of the N,N-diacetylchitobiose-specific and lichenan-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In these systems, EII is either a lichenan- or an N; Region: PTS_IIB_chitobiose_lichenan; cd05564 481805006206 active site 481805006207 P-loop; other site 481805006208 phosphorylation site [posttranslational modification] 481805006209 PTS system N,N'-diacetylchitobiose-specific transporter subunit IIC; Provisional; Region: PRK10297 481805006210 cellobiose phosphotransferase system IIC component; Reviewed; Region: celD; PRK09592 481805006211 PTS_IIA, PTS system, lactose/cellobiose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_lac; cd00215 481805006212 methionine cluster; other site 481805006213 active site 481805006214 phosphorylation site [posttranslational modification] 481805006215 metal binding site [ion binding]; metal-binding site 481805006216 DNA-binding transcriptional regulator ChbR; Provisional; Region: PRK10296 481805006217 Cupin domain; Region: Cupin_2; pfam07883 481805006218 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805006219 Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases [Carbohydrate transport and metabolism]; Region: CelF; COG1486 481805006220 Glycoside Hydrolases Family 4; Phospho-beta-glucosidase; Region: GH4_P_beta_glucosidase; cd05296 481805006221 NAD binding site [chemical binding]; other site 481805006222 sugar binding site [chemical binding]; other site 481805006223 divalent metal binding site [ion binding]; other site 481805006224 tetramer (dimer of dimers) interface [polypeptide binding]; other site 481805006225 dimer interface [polypeptide binding]; other site 481805006226 Enterococcus faecalis EF3048 and similar proteins; Region: YdjC_EF3048_like; cd10803 481805006227 putative active site [active] 481805006228 YdjC motif; other site 481805006229 Mg binding site [ion binding]; other site 481805006230 putative homodimer interface [polypeptide binding]; other site 481805006231 hydroperoxidase II; Provisional; Region: katE; PRK11249 481805006232 Clade 2 of the heme-binding enzyme catalase; Region: catalase_clade_2; cd08155 481805006233 tetramer interface [polypeptide binding]; other site 481805006234 heme binding pocket [chemical binding]; other site 481805006235 Type 1 glutamine amidotransferase (GATase1)-like domain found in at the C-terminal of several large catalases; Region: GATase1_catalase; cd03132 481805006236 domain interactions; other site 481805006237 cell division modulator; Provisional; Region: PRK10113 481805006238 Predicted Na+/dicarboxylate symporter [General function prediction only]; Region: COG1823 481805006239 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 481805006240 inner membrane protein; Provisional; Region: PRK11648 481805006241 2-deoxyglucose-6-phosphatase; Provisional; Region: PRK10826 481805006242 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 481805006243 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805006244 motif II; other site 481805006245 YniB-like protein; Region: YniB; pfam14002 481805006246 Phosphotransferase enzyme family; Region: APH; pfam01636 481805006247 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 481805006248 active site 481805006249 ATP binding site [chemical binding]; other site 481805006250 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cl17270 481805006251 Protein of unknown function (DUF2622); Region: DUF2622; pfam11080 481805006252 6-phosphofructokinase 2; Provisional; Region: PRK10294 481805006253 1-phosphofructokinase (FruK), minor 6-phosphofructokinase (pfkB) and related sugar kinases. FruK plays an important role in the predominant pathway for fructose utilisation.This group also contains tagatose-6-phophate kinase, an enzyme of the tagatose...; Region: FruK_PfkB_like; cd01164 481805006254 putative substrate binding site [chemical binding]; other site 481805006255 putative ATP binding site [chemical binding]; other site 481805006256 Putative salt-induced outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG3137 481805006257 threonyl-tRNA synthetase; Reviewed; Region: thrS; PRK00413 481805006258 TGS _ThrRS_N: ThrRS (threonyl-tRNA Synthetase) is a class II tRNA synthetase that couples threonine to its cognate tRNA. In addition to its catalytic and anticodon-binding domains, ThrRS has an N-terminal TGS domain, named after the ThrRS, GTPase, and...; Region: TGS_ThrRS_N; cd01667 481805006259 Threonyl and Alanyl tRNA synthetase second additional domain; Region: tRNA_SAD; pfam07973 481805006260 Threonyl-tRNA synthetase (ThrRS) class II core catalytic domain. ThrRS is a homodimer. It is responsible for the attachment of threonine to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ThrRS_core; cd00771 481805006261 active site 481805006262 dimer interface [polypeptide binding]; other site 481805006263 motif 1; other site 481805006264 motif 2; other site 481805006265 motif 3; other site 481805006266 ThrRS Threonyl-anticodon binding domain. ThrRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding, so that the activated amino acid is...; Region: ThrRS_anticodon; cd00860 481805006267 anticodon binding site; other site 481805006268 translation initiation factor IF-3; Reviewed; Region: infC; PRK00028 481805006269 Translation initiation factor IF-3, N-terminal domain; Region: IF3_N; pfam05198 481805006270 Translation initiation factor IF-3, C-terminal domain; Region: IF3_C; pfam00707 481805006271 50S ribosomal protein L35; Reviewed; Region: rpmI; PRK00172 481805006272 Ribosomal protein L20; Region: Ribosomal_L20; cd07026 481805006273 23S rRNA binding site [nucleotide binding]; other site 481805006274 L21 binding site [polypeptide binding]; other site 481805006275 L13 binding site [polypeptide binding]; other site 481805006276 phenylalanyl-tRNA synthetase subunit alpha; Validated; Region: pheS; PRK00488 481805006277 Aminoacyl tRNA synthetase class II, N-terminal domain; Region: Phe_tRNA-synt_N; pfam02912 481805006278 Phenylalanyl-tRNA synthetase (PheRS) alpha chain catalytic core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs. This domain is primarily responsible...; Region: PheRS_alpha_core; cd00496 481805006279 dimer interface [polypeptide binding]; other site 481805006280 motif 1; other site 481805006281 active site 481805006282 motif 2; other site 481805006283 motif 3; other site 481805006284 phenylalanyl-tRNA synthetase subunit beta; Reviewed; Region: pheT; PRK00629 481805006285 tRNA-binding-domain-containing prokaryotic phenylalanly tRNA synthetase (PheRS) beta chain. PheRS aminoacylate phenylalanine transfer RNAs (tRNAphe). PheRSs belong structurally to class II aminoacyl tRNA synthetases (aaRSs) but, as they aminoacylate...; Region: tRNA_bind_bactPheRS; cd02796 481805006286 putative tRNA-binding site [nucleotide binding]; other site 481805006287 B3/4 domain; Region: B3_4; pfam03483 481805006288 tRNA synthetase B5 domain; Region: B5; smart00874 481805006289 Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an...; Region: PheRS_beta_core; cd00769 481805006290 dimer interface [polypeptide binding]; other site 481805006291 motif 1; other site 481805006292 motif 3; other site 481805006293 motif 2; other site 481805006294 Ferredoxin-fold anticodon binding domain; Region: FDX-ACB; pfam03147 481805006295 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 481805006296 IHF dimer interface [polypeptide binding]; other site 481805006297 IHF - DNA interface [nucleotide binding]; other site 481805006298 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 481805006299 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481805006300 ABC-ATPase subunit interface; other site 481805006301 dimer interface [polypeptide binding]; other site 481805006302 putative PBP binding regions; other site 481805006303 Glutathione (GSH) peroxidase family; tetrameric selenoenzymes that catalyze the reduction of a variety of hydroperoxides including lipid peroxidases, using GSH as a specific electron donor substrate. GSH peroxidase contains one selenocysteine residue per...; Region: GSH_Peroxidase; cd00340 481805006304 catalytic residues [active] 481805006305 dimer interface [polypeptide binding]; other site 481805006306 vitamin B12-transporter ATPase; Provisional; Region: PRK03695 481805006307 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 481805006308 Walker A/P-loop; other site 481805006309 ATP binding site [chemical binding]; other site 481805006310 Q-loop/lid; other site 481805006311 ABC transporter signature motif; other site 481805006312 Walker B; other site 481805006313 D-loop; other site 481805006314 H-loop/switch region; other site 481805006315 NlpC/P60 family; Region: NLPC_P60; pfam00877 481805006316 c-di-GMP phosphodiesterase class I (EAL domain) [Signal transduction mechanisms]; Region: Rtn; COG2200 481805006317 Uncharacterized conserved protein [Function unknown]; Region: COG0397 481805006318 hypothetical protein; Validated; Region: PRK00029 481805006319 Hemin uptake protein [Inorganic ion transport and metabolism]; Region: HemP; COG4256 481805006320 phospho-2-dehydro-3-deoxyheptonate aldolase; Provisional; Region: PRK12756 481805006321 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 481805006322 PEP synthetase regulatory protein; Provisional; Region: PRK05339 481805006323 phosphoenolpyruvate synthase; Validated; Region: PRK06464 481805006324 Pyruvate phosphate dikinase, PEP/pyruvate binding domain; Region: PPDK_N; pfam01326 481805006325 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 481805006326 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 481805006327 short chain acyl-CoA synthetase; Reviewed; Region: PRK06087 481805006328 Cyclohexanecarboxylate-CoA ligase (also called cyclohex-1-ene-1-carboxylate:CoA ligase); Region: CHC_CoA_lg; cd05903 481805006329 acyl-activating enzyme (AAE) consensus motif; other site 481805006330 putative AMP binding site [chemical binding]; other site 481805006331 putative active site [active] 481805006332 putative CoA binding site [chemical binding]; other site 481805006333 Ferredoxin-like protein [Energy production and conversion]; Region: FixX; COG2440 481805006334 oxidoreductase; Provisional; Region: PRK10015 481805006335 electron transfer flavoprotein subunit YdiR; Provisional; Region: PRK11916 481805006336 Electron transfer flavoprotein domain; Region: ETF; smart00893 481805006337 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 481805006338 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 481805006339 Ligand binding site [chemical binding]; other site 481805006340 Electron transfer flavoprotein domain; Region: ETF; pfam01012 481805006341 Cupin domain; Region: Cupin_2; pfam07883 481805006342 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481805006343 putative acyl-CoA dehydrogenase; Provisional; Region: PRK12341 481805006344 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 481805006345 active site 481805006346 Acyl CoA:acetate/3-ketoacid CoA transferase [Lipid metabolism]; Region: COG4670 481805006347 Coenzyme A transferase; Region: CoA_trans; smart00882 481805006348 Coenzyme A transferase; Region: CoA_trans; cl17247 481805006349 3-dehydroquinate dehydratase [Amino acid transport and metabolism]; Region: AroD; COG0710 481805006350 Type I 3-dehydroquinase, (3-dehydroquinate dehydratase or DHQase); Region: DHQase_I; cd00502 481805006351 active site 481805006352 catalytic residue [active] 481805006353 dimer interface [polypeptide binding]; other site 481805006354 quinate/shikimate dehydrogenase; Reviewed; Region: PRK12749 481805006355 Shikimate dehydrogenase substrate binding domain; Region: Shikimate_dh_N; pfam08501 481805006356 NAD(P) binding domain of Shikimate dehydrogenase; Region: NAD_bind_Shikimate_DH; cd01065 481805006357 shikimate binding site; other site 481805006358 NAD(P) binding site [chemical binding]; other site 481805006359 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805006360 putative substrate translocation pore; other site 481805006361 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805006362 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481805006363 putative substrate translocation pore; other site 481805006364 Domain of unknown function (DUF1870); Region: DUF1870; pfam08965 481805006365 putative inner membrane protein; Provisional; Region: PRK10983 481805006366 Domain of unknown function DUF20; Region: UPF0118; pfam01594 481805006367 FAD/FMN-containing dehydrogenases [Energy production and conversion]; Region: GlcD; COG0277 481805006368 FAD binding domain; Region: FAD_binding_4; pfam01565 481805006369 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 481805006370 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 481805006371 CoenzymeA binding site [chemical binding]; other site 481805006372 subunit interaction site [polypeptide binding]; other site 481805006373 PHB binding site; other site 481805006374 iron-sulfur cluster assembly scaffold protein; Provisional; Region: sufA; PRK09504 481805006375 cysteine desulfurase activator complex subunit SufB; Provisional; Region: PRK11814 481805006376 putative ABC transporter; Region: ycf24; CHL00085 481805006377 cysteine desulfurase ATPase component; Reviewed; Region: sufC; PRK09580 481805006378 ABC-type transport system involved in Fe-S cluster assembly, ATPase component; Region: ABC_FeS_Assembly; cd03217 481805006379 Walker A/P-loop; other site 481805006380 ATP binding site [chemical binding]; other site 481805006381 Q-loop/lid; other site 481805006382 ABC transporter signature motif; other site 481805006383 Walker B; other site 481805006384 D-loop; other site 481805006385 H-loop/switch region; other site 481805006386 cysteine desulfurase activator complex subunit SufD; Provisional; Region: PRK10948 481805006387 FeS assembly protein SufD; Region: sufD; TIGR01981 481805006388 Selenocysteine lyase/Cysteine desulfurase [Posttranslational modification, protein turnover, chaperones]; Region: csdA; COG0520 481805006389 Cysteine desulfurase (SufS)-like. This family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to cysteine desulfurase (SufS) and selenocysteine lyase. SufS...; Region: SufS_like; cd06453 481805006390 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 481805006391 catalytic residue [active] 481805006392 cysteine desufuration protein SufE; Provisional; Region: PRK09296 481805006393 L,D-transpeptidase; Provisional; Region: PRK10190 481805006394 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481805006395 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 481805006396 murein lipoprotein; Provisional; Region: PRK15396 481805006397 pyruvate kinase; Provisional; Region: PRK09206 481805006398 Pyruvate kinase (PK): Large allosteric enzyme that regulates glycolysis through binding of the substrate, phosphoenolpyruvate, and one or more allosteric effectors. Like other allosteric enzymes, PK has a high substrate affinity R state and a low...; Region: Pyruvate_Kinase; cd00288 481805006399 domain interfaces; other site 481805006400 active site 481805006401 hypothetical protein; Provisional; Region: PRK10292 481805006402 hypothetical protein; Provisional; Region: PRK09898 481805006403 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 481805006404 putative oxidoreductase; Provisional; Region: PRK09849 481805006405 Aldehyde ferredoxin oxidoreductase, N-terminal domain; Region: AFOR_N; pfam02730 481805006406 Aldehyde ferredoxin oxidoreductase, domains 2 & 3; Region: AFOR_C; pfam01314 481805006407 hypothetical protein; Provisional; Region: PRK09947 481805006408 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 481805006409 thiosulfate reductase cytochrome B subunit; Provisional; Region: PRK15006 481805006410 Thiosulfate reductase cytochrome B subunit (membrane anchoring protein) [Energy production and conversion]; Region: COG4117 481805006411 hypothetical protein; Provisional; Region: PRK09946 481805006412 hypothetical protein; Provisional; Region: PRK09897 481805006413 FAD-NAD(P)-binding; Region: NAD_binding_9; pfam13454 481805006414 putative monooxygenase; Provisional; Region: PRK11118 481805006415 hypothetical protein; Provisional; Region: PRK09945 481805006416 Type V secretory pathway, adhesin AidA [Cell envelope biogenesis, outer membrane / Intracellular trafficking and secretion]; Region: AidA; COG3468 481805006417 multidrug efflux protein; Reviewed; Region: PRK01766 481805006418 Subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins similar to Vibrio cholerae NorM; Region: MATE_NorM_like; cd13131 481805006419 cation binding site [ion binding]; other site 481805006420 riboflavin synthase subunit alpha; Provisional; Region: PRK13020 481805006421 Lumazine binding domain; Region: Lum_binding; pfam00677 481805006422 Lumazine binding domain; Region: Lum_binding; pfam00677 481805006423 cyclopropane fatty acyl phospholipid synthase; Provisional; Region: PRK11705 481805006424 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cl17173 481805006425 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805006426 S-adenosylmethionine binding site [chemical binding]; other site 481805006427 putative transporter; Provisional; Region: PRK11043 481805006428 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805006429 putative substrate translocation pore; other site 481805006430 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11074 481805006431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805006432 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481805006433 dimerization interface [polypeptide binding]; other site 481805006434 DNA-binding transcriptional repressor PurR; Provisional; Region: PRK10703 481805006435 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481805006436 DNA binding site [nucleotide binding] 481805006437 domain linker motif; other site 481805006438 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 481805006439 dimerization interface [polypeptide binding]; other site 481805006440 ligand binding site [chemical binding]; other site 481805006441 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805006442 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481805006443 putative substrate translocation pore; other site 481805006444 superoxide dismutase; Provisional; Region: PRK10543 481805006445 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 481805006446 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 481805006447 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 481805006448 NlpC/P60 family; Region: NLPC_P60; pfam00877 481805006449 Glutaredoxin (GRX) family, PKC-interacting cousin of TRX (PICOT)-like subfamily; composed of PICOT and GRX-PICOT-like proteins. The non-PICOT members of this family contain only the GRX-like domain, whereas PICOT contains an N-terminal TRX-like domain...; Region: GRX_PICOT_like; cd03028 481805006450 putative GSH binding site [chemical binding]; other site 481805006451 catalytic residues [active] 481805006452 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481805006453 putative ATP-dependent helicase Lhr; Provisional; Region: PRK09751 481805006454 ATP binding site [chemical binding]; other site 481805006455 putative Mg++ binding site [ion binding]; other site 481805006456 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805006457 nucleotide binding region [chemical binding]; other site 481805006458 ATP-binding site [chemical binding]; other site 481805006459 DEAD/H associated; Region: DEAD_assoc; pfam08494 481805006460 DNA polymerase III, epsilon subunit and related 3'-5' exonucleases [DNA replication, recombination, and repair]; Region: DnaQ; COG0847 481805006461 DEDDh 3'-5' exonuclease domain of RNase T; Region: RNaseT; cd06134 481805006462 dimer interface [polypeptide binding]; other site 481805006463 catalytic site [active] 481805006464 putative active site [active] 481805006465 putative substrate binding site [chemical binding]; other site 481805006466 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481805006467 Glyoxalase I catalyzes the isomerization of the hemithioacetal, formed by a 2-oxoaldehyde and glutathione, to S-D-lactoylglutathione; Region: Glyoxalase_I; cd07233 481805006468 dimer interface [polypeptide binding]; other site 481805006469 active site 481805006470 metal binding site [ion binding]; metal-binding site 481805006471 glutathione binding site [chemical binding]; other site 481805006472 NADH:flavin oxidoreductases, Old Yellow Enzyme family [Energy production and conversion]; Region: NemA; COG1902 481805006473 Old yellow enzyme (OYE)-like FMN binding domain. OYE was the first flavin-dependent enzyme identified, however its true physiological role remains elusive to this day. Each monomer of OYE contains FMN as a non-covalently bound cofactor, uses NADPH as a...; Region: OYE_like_FMN; cd02933 481805006474 FMN binding site [chemical binding]; other site 481805006475 active site 481805006476 substrate binding site [chemical binding]; other site 481805006477 catalytic residue [active] 481805006478 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481805006479 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481805006480 Predicted Fe-S protein [General function prediction only]; Region: COG3313 481805006481 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481805006482 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481805006483 active site 481805006484 catalytic tetrad [active] 481805006485 Cu/Zn superoxide dismutase [Inorganic ion transport and metabolism]; Region: SodC; COG2032 481805006486 Copper/zinc superoxide dismutase (SOD). superoxide dismutases catalyse the conversion of superoxide radicals to molecular oxygen. Three evolutionarily distinct families of SODs are known, of which the copper/zinc-binding family is one. Defects in the...; Region: Cu-Zn_Superoxide_Dismutase; cd00305 481805006487 E-class dimer interface [polypeptide binding]; other site 481805006488 P-class dimer interface [polypeptide binding]; other site 481805006489 active site 481805006490 Cu2+ binding site [ion binding]; other site 481805006491 Zn2+ binding site [ion binding]; other site 481805006492 Fusaric acid resistance protein family; Region: FUSC; pfam04632 481805006493 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 481805006494 Multidrug resistance efflux pump [Defense mechanisms]; Region: EmrA; COG1566 481805006495 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481805006496 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805006497 Protein of unknown function (DUF1656); Region: DUF1656; cl11658 481805006498 transcriptional regulator SlyA; Provisional; Region: PRK03573 481805006499 Winged helix DNA-binding domain; Region: HTH_27; pfam13463 481805006500 Outer membrane lipoprotein [Cell envelope biogenesis, outer membrane]; Region: SlyB; COG3133 481805006501 Uncharacterized protein family (UPF0075); Region: UPF0075; pfam03702 481805006502 lysozyme inhibitor; Provisional; Region: PRK11372 481805006503 Membrane-bound lysozyme-inhibitor of c-type lysozyme; Region: MliC; pfam09864 481805006504 pyridoxamine 5'-phosphate oxidase; Provisional; Region: PRK05679 481805006505 Pyridoxamine 5'-phosphate oxidase; Region: Pyridox_oxidase; pfam01243 481805006506 Pyridoxine 5'-phosphate oxidase C-terminal dimerisation region; Region: PNPOx_C; pfam10590 481805006507 tyrosyl-tRNA synthetase; Validated; Region: PRK05912 481805006508 catalytic core domain of tyrosinyl-tRNA synthetase; Region: TyrRS_core; cd00805 481805006509 active site 481805006510 HIGH motif; other site 481805006511 dimer interface [polypeptide binding]; other site 481805006512 KMSKS motif; other site 481805006513 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481805006514 RNA binding surface [nucleotide binding]; other site 481805006515 pyridoxamine kinase; Validated; Region: PRK05756 481805006516 Pyridoxal kinase plays a key role in the synthesis of the active coenzyme pyridoxal-5'-phosphate (PLP), by catalyzing the phosphorylation of the precursor vitamin B6 in the presence of Zn2+ and ATP. Mammals are unable to synthesize PLP de novo and...; Region: pyridoxal_pyridoxamine_kinase; cd01173 481805006517 dimer interface [polypeptide binding]; other site 481805006518 pyridoxal binding site [chemical binding]; other site 481805006519 ATP binding site [chemical binding]; other site 481805006520 glutathionine S-transferase; Provisional; Region: PRK10542 481805006521 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 481805006522 C-terminal domain interface [polypeptide binding]; other site 481805006523 GSH binding site (G-site) [chemical binding]; other site 481805006524 dimer interface [polypeptide binding]; other site 481805006525 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 481805006526 N-terminal domain interface [polypeptide binding]; other site 481805006527 dimer interface [polypeptide binding]; other site 481805006528 substrate binding pocket (H-site) [chemical binding]; other site 481805006529 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 481805006530 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805006531 putative substrate translocation pore; other site 481805006532 POT family; Region: PTR2; pfam00854 481805006533 endonuclease III; Provisional; Region: PRK10702 481805006534 endonuclease III; includes endonuclease III (DNA-(apurinic or apyrimidinic site) lyase), alkylbase DNA glycosidases (Alka-family) and other DNA glycosidases; Region: ENDO3c; cd00056 481805006535 minor groove reading motif; other site 481805006536 helix-hairpin-helix signature motif; other site 481805006537 substrate binding pocket [chemical binding]; other site 481805006538 active site 481805006539 iron-sulpphur binding domain in DNA-(apurinic or apyrimidinic site) lyase (subfamily of ENDO3); Region: FES; smart00525 481805006540 electron transport complex RsxE subunit; Provisional; Region: PRK12405 481805006541 electron transport complex protein RnfG; Validated; Region: PRK01908 481805006542 electron transport complex protein RnfD; Reviewed; Region: rnfD; PRK00816 481805006543 Predicted NADH:ubiquinone oxidoreductase, subunit RnfC [Energy production and conversion]; Region: RnfC; COG4656 481805006544 SLBB domain; Region: SLBB; pfam10531 481805006545 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 481805006546 electron transport complex protein RnfB; Provisional; Region: PRK05113 481805006547 Putative Fe-S cluster; Region: FeS; pfam04060 481805006548 4Fe-4S binding domain; Region: Fer4; pfam00037 481805006549 electron transport complex protein RsxA; Provisional; Region: PRK05151 481805006550 Protein of unknown function (DUF2569); Region: DUF2569; pfam10754 481805006551 oriC-binding nucleoid-associated protein; Provisional; Region: PRK10391 481805006552 putative oxidoreductase; Provisional; Region: PRK11579 481805006553 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481805006554 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481805006555 Adenosine deaminase [Nucleotide transport and metabolism]; Region: Add; COG1816 481805006556 Adenosine deaminase (ADA) is a monomeric zinc dependent enzyme which catalyzes the irreversible hydrolytic deamination of both adenosine, as well as desoxyadenosine, to ammonia and inosine or desoxyinosine, respectively. ADA plays an important role in...; Region: ADA; cd01320 481805006557 active site 481805006558 purine riboside binding site [chemical binding]; other site 481805006559 Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities [Amino acid transport and metabolism]; Region: MalY; COG1168 481805006560 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481805006561 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805006562 homodimer interface [polypeptide binding]; other site 481805006563 catalytic residue [active] 481805006564 DNA-binding transcriptional repressor MalI; Provisional; Region: PRK10014 481805006565 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481805006566 DNA binding site [nucleotide binding] 481805006567 domain linker motif; other site 481805006568 Ligand-binding domain of MalI, a transcription regulator of the maltose system of Escherichia coli and its close homologs from other bacteria; Region: PBP1_MalI_like; cd06289 481805006569 putative dimerization interface [polypeptide binding]; other site 481805006570 putative ligand binding site [chemical binding]; other site 481805006571 7-alpha-hydroxysteroid dehydrogenase; Validated; Region: PRK06113 481805006572 7 alpha-hydroxysteroid dehydrogenase (7 alpha-HSDH), classical (c) SDRs; Region: 7_alpha_HSDH_SDR_c; cd05365 481805006573 NAD binding site [chemical binding]; other site 481805006574 substrate binding site [chemical binding]; other site 481805006575 homotetramer interface [polypeptide binding]; other site 481805006576 homodimer interface [polypeptide binding]; other site 481805006577 active site 481805006578 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481805006579 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481805006580 beta-D-glucuronidase; Provisional; Region: PRK10150 481805006581 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481805006582 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481805006583 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481805006584 putative outer membrane porin protein; Provisional; Region: PRK11379 481805006585 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 481805006586 Bacterial protein of unknown function (DUF945); Region: DUF945; pfam06097 481805006587 mannose-6-phosphate isomerase; Provisional; Region: PRK15131 481805006588 Alpha-Mannosidase Binding Domain of Atg19/34; Region: ABD; cl15429 481805006589 mannose-6-phosphate isomerase, class I; Region: manA; TIGR00218 481805006590 fumarate hydratase; Provisional; Region: PRK15389 481805006591 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 481805006592 Fumarase C-terminus; Region: Fumerase_C; pfam05683 481805006593 fumarate hydratase; Reviewed; Region: fumC; PRK00485 481805006594 Class II fumarases; Region: Fumarase_classII; cd01362 481805006595 active site 481805006596 tetramer interface [polypeptide binding]; other site 481805006597 DNA replication terminus site-binding protein; Provisional; Region: PRK02951 481805006598 sensor protein RstB; Provisional; Region: PRK10604 481805006599 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805006600 dimerization interface [polypeptide binding]; other site 481805006601 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805006602 dimer interface [polypeptide binding]; other site 481805006603 phosphorylation site [posttranslational modification] 481805006604 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805006605 ATP binding site [chemical binding]; other site 481805006606 Mg2+ binding site [ion binding]; other site 481805006607 G-X-G motif; other site 481805006608 DNA-binding transcriptional regulator RstA; Provisional; Region: PRK10701 481805006609 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805006610 active site 481805006611 phosphorylation site [posttranslational modification] 481805006612 intermolecular recognition site; other site 481805006613 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805006614 DNA binding site [nucleotide binding] 481805006615 GlpM protein; Region: GlpM; pfam06942 481805006616 dihydromonapterin reductase; Provisional; Region: PRK06483 481805006617 pteridine reductase (PR), classical (c) SDRs; Region: PR_SDR_c; cd05357 481805006618 NADP binding site [chemical binding]; other site 481805006619 substrate binding pocket [chemical binding]; other site 481805006620 active site 481805006621 transporter, basic amino acid/polyamine antiporter (APA) family; Region: 2A0302; TIGR00905 481805006622 Spore germination protein; Region: Spore_permease; cl17796 481805006623 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 481805006624 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 481805006625 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 481805006626 NAD(P) transhydrogenase subunit alpha; Provisional; Region: pntA; PRK09424 481805006627 Rubrum transdehydrogenase NAD-binding and catalytic domains; Region: Rubrum_tdh; cd05304 481805006628 ligand binding site [chemical binding]; other site 481805006629 homodimer interface [polypeptide binding]; other site 481805006630 NAD(P) binding site [chemical binding]; other site 481805006631 trimer interface B [polypeptide binding]; other site 481805006632 trimer interface A [polypeptide binding]; other site 481805006633 Domain of unknown function (DUF3814); Region: DUF3814; pfam12769 481805006634 pyridine nucleotide transhydrogenase; Provisional; Region: pntB; PRK09444 481805006635 NAD(P) transhydrogenase beta subunit; Region: PNTB; pfam02233 481805006636 pheromone autoinducer 2 transporter; Reviewed; Region: tqsA; PRK12287 481805006637 Domain of unknown function DUF20; Region: UPF0118; pfam01594 481805006638 multidrug efflux system protein MdtJ; Provisional; Region: PRK10452 481805006639 multidrug efflux system protein MdtI; Provisional; Region: PRK10650 481805006640 V8-like Glu-specific endopeptidase [Amino acid transport and metabolism]; Region: COG3591 481805006641 Arabinose efflux permease [Carbohydrate transport and metabolism]; Region: AraJ; COG2814 481805006642 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805006643 putative substrate translocation pore; other site 481805006644 DNA-binding transcriptional activator XapR; Provisional; Region: PRK09986 481805006645 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805006646 The C-terminal substrate binding domain of LysR-type transcriptional regulators involved in the catabolism of aromatic compounds and that of other related regulators, contains type 2 periplasmic binding fold; Region: PBP2_LTTR_aromatics_like; cd08414 481805006647 dimerization interface [polypeptide binding]; other site 481805006648 substrate binding pocket [chemical binding]; other site 481805006649 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 481805006650 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 481805006651 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481805006652 nucleotide binding site [chemical binding]; other site 481805006653 putative dithiobiotin synthetase; Provisional; Region: PRK12374 481805006654 AAA domain; Region: AAA_26; pfam13500 481805006655 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 481805006656 CLC voltage-gated chloride channel. The ClC chloride channels catalyse the selective flow of Cl- ions across cell membranes, thereby regulating electrical excitation in skeletal muscle and the flow of salt and water across epithelial barriers. This...; Region: Voltage_gated_ClC; cd00400 481805006657 Cl- selectivity filter; other site 481805006658 Cl- binding residues [ion binding]; other site 481805006659 pore gating glutamate residue; other site 481805006660 dimer interface [polypeptide binding]; other site 481805006661 twin-argninine leader-binding protein DmsD; Provisional; Region: PRK11621 481805006662 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 481805006663 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 481805006664 4Fe-4S binding domain; Region: Fer4; cl02805 481805006665 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 481805006666 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 481805006667 putative [Fe4-S4] binding site [ion binding]; other site 481805006668 putative molybdopterin cofactor binding site [chemical binding]; other site 481805006669 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 481805006670 putative molybdopterin cofactor binding site; other site 481805006671 anaerobic dimethyl sulfoxide reductase, A subunit, DmsA/YnfE family; Region: dmsA_ynfE; TIGR02166 481805006672 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 481805006673 putative [Fe4-S4] binding site [ion binding]; other site 481805006674 putative molybdopterin cofactor binding site [chemical binding]; other site 481805006675 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 481805006676 putative molybdopterin cofactor binding site; other site 481805006677 Protein of unknown function (DUF1161); Region: DUF1161; pfam06649 481805006678 Uncharacterized protein family (UPF0257); Region: UPF0257; pfam06788 481805006679 spermidine N1-acetyltransferase; Provisional; Region: PRK15130 481805006680 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481805006681 Coenzyme A binding pocket [chemical binding]; other site 481805006682 hypothetical protein; Provisional; Region: PRK13659 481805006683 hypothetical protein; Provisional; Region: PRK02237 481805006684 bifunctional D-altronate/D-mannonate dehydratase; Provisional; Region: PRK15072 481805006685 The starvation sensing protein RpsA from E.coli and its homologs are lactonizing enzymes whose putative targets are homoserine lactone (HSL)-derivative. They are part of the mandelate racemase (MR)-like subfamily of the enolase superfamily. Enzymes of...; Region: rpsA; cd03322 481805006686 putative active site pocket [active] 481805006687 putative metal binding site [ion binding]; other site 481805006688 putative oxidoreductase; Provisional; Region: PRK10083 481805006689 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 481805006690 putative NAD(P) binding site [chemical binding]; other site 481805006691 catalytic Zn binding site [ion binding]; other site 481805006692 structural Zn binding site [ion binding]; other site 481805006693 Domain of unknown function (DUF3596); Region: DUF3596; pfam12167 481805006694 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 481805006695 phiCTX phage and phage-related integrases, site-specific recombinases, DNA breaking-rejoining enzymes, C-terminal catalytic domain. This CD includes various phage and bacterial integrases, including those similar to phage integrases: Bordetella and...; Region: INT_phiCTX_C; cd01191 481805006696 Int/Topo IB signature motif; other site 481805006697 Putative excisionase (DUF1233); Region: DUF1233; pfam06806 481805006698 DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily; Region: DnaQ_like_exo; cl10012 481805006699 active site 481805006700 catalytic site [active] 481805006701 substrate binding site [chemical binding]; other site 481805006702 Protein of unknown function (DUF1482); Region: DUF1482; pfam07358 481805006703 Protein of unknown function (DUF1391); Region: DUF1391; pfam07151 481805006704 transcriptional repressor DicA; Reviewed; Region: PRK09706 481805006705 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805006706 non-specific DNA binding site [nucleotide binding]; other site 481805006707 salt bridge; other site 481805006708 sequence-specific DNA binding site [nucleotide binding]; other site 481805006709 DNA-binding transcriptional regulator DicC; Provisional; Region: PRK09744 481805006710 Protein of unknown function (DUF1019); Region: DUF1019; pfam06254 481805006711 primosomal protein DnaI; Provisional; Region: PRK02854 481805006712 Bacterial protein of unknown function (DUF977); Region: DUF977; pfam06163 481805006713 Methyltransferase domain; Region: Methyltransf_25; pfam13649 481805006714 Homeodomain-like domain; Region: HTH_23; pfam13384 481805006715 Winged helix-turn helix; Region: HTH_29; pfam13551 481805006716 Homeodomain-like domain; Region: HTH_32; pfam13565 481805006717 Integrase core domain; Region: rve; pfam00665 481805006718 Integrase core domain; Region: rve_3; cl15866 481805006719 bifunctional antitoxin/transcriptional repressor RelB; Provisional; Region: PRK11235 481805006720 Cytotoxic translational repressor of toxin-antitoxin stability system [Translation, ribosomal structure and biogenesis / Cell division and chromosome partitioning]; Region: RelE; COG2026 481805006721 Hok/gef family; Region: HOK_GEF; pfam01848 481805006722 Protein of unknown function (DUF968); Region: DUF968; pfam06147 481805006723 Antitermination protein; Region: Antiterm; pfam03589 481805006724 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 481805006725 DnaJ central domain; Region: DnaJ_CXXCXGXG; pfam00684 481805006726 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 481805006727 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 481805006728 DNA-binding site [nucleotide binding]; DNA binding site 481805006729 RNA-binding motif; other site 481805006730 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 481805006731 DNA-binding site [nucleotide binding]; DNA binding site 481805006732 RNA-binding motif; other site 481805006733 Lysis protein S; Region: Lysis_S; pfam04971 481805006734 Protein of unknown function (DUF1327); Region: DUF1327; pfam07041 481805006735 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 481805006736 catalytic residues [active] 481805006737 Protein of unknown function (DUF2514); Region: DUF2514; pfam10721 481805006738 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 481805006739 DNA-binding site [nucleotide binding]; DNA binding site 481805006740 RNA-binding motif; other site 481805006741 GnsA/GnsB family; Region: GnsAB; pfam08178 481805006742 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 481805006743 Domain of unknown function (DUF3950); Region: DUF3950; pfam13132 481805006744 Phage DNA packaging protein Nu1; Region: Phage_Nu1; pfam07471 481805006745 Phage terminase, large subunit GpA [Replication, recombination and repair]; Region: COG5525 481805006746 gpW; Region: gpW; pfam02831 481805006747 Bacteriophage capsid protein [General function prediction only]; Region: COG5511 481805006748 phage portal protein, lambda family; Region: portal_lambda; TIGR01539 481805006749 Signal peptide peptidase A (SppA) 36K type, a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_36K_type; cd07022 481805006750 signal peptide peptidase SppA, 36K type; Region: SppA_dom; TIGR00706 481805006751 tandem repeat interface [polypeptide binding]; other site 481805006752 oligomer interface [polypeptide binding]; other site 481805006753 active site residues [active] 481805006754 Bacteriophage lambda head decoration protein D; Region: HDPD; pfam02924 481805006755 Phage major capsid protein E; Region: Phage_cap_E; pfam03864 481805006756 DNA packaging protein FI; Region: Packaging_FI; pfam14000 481805006757 Phage Head-Tail Attachment; Region: Phage_attach; pfam05354 481805006758 Prophage minor tail protein Z (GPZ); Region: Minor_tail_Z; pfam06763 481805006759 Phage minor tail protein U; Region: Phage_tail_U; pfam06141 481805006760 Bacterial surface proteins containing Ig-like domains [Cell motility and secretion]; Region: COG5492 481805006761 Bacterial Ig-like domain (group 2); Region: Big_2; pfam02368 481805006762 Bacteriophage lambda minor tail protein (GpG); Region: Phage_lambd_GpG; pfam06894 481805006763 Minor tail protein T; Region: Phage_tail_T; pfam06223 481805006764 Phage-related minor tail protein [Function unknown]; Region: COG5281 481805006765 Prophage tail length tape measure protein; Region: TMP_2; pfam06791 481805006766 Lambda phage tail tape-measure protein (Tape_meas_lam_C); Region: Tape_meas_lam_C; pfam09718 481805006767 Phage-related protein [Function unknown]; Region: COG4718 481805006768 Phage-related protein [Function unknown]; Region: gp18; COG4672 481805006769 Mpr1p, Pad1p N-terminal (MPN) domains with catalytic isopeptidase activity (metal-binding) found in proteins also containing NlpC/P60 domains; Region: MPN_NLPC_P60; cd08073 481805006770 MPN+ (JAMM) motif; other site 481805006771 Zinc-binding site [ion binding]; other site 481805006772 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 481805006773 NlpC/P60 family; Region: NLPC_P60; cl17555 481805006774 Phage-related protein, tail component [Function unknown]; Region: COG4723 481805006775 Phage-related protein, tail component [Function unknown]; Region: COG4733 481805006776 Putative phage tail protein; Region: Phage-tail_3; pfam13550 481805006777 Fibronectin type 3 domain; Region: FN3; smart00060 481805006778 Domain of unknown function (DUF1983); Region: DUF1983; pfam09327 481805006779 Fibronectin type III protein; Region: DUF3672; pfam12421 481805006780 Outer membrane protein beta-barrel domain; Region: OMP_b-brl; cl17254 481805006781 Prophage tail fibre N-terminal; Region: phage_tail_N; pfam08400 481805006782 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 481805006783 Phage tail fibre repeat; Region: Phage_fiber_2; pfam03406 481805006784 Phage Tail Collar Domain; Region: Collar; pfam07484 481805006785 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 481805006786 multiple promoter invertase; Provisional; Region: mpi; PRK13413 481805006787 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 481805006788 catalytic residues [active] 481805006789 catalytic nucleophile [active] 481805006790 Presynaptic Site I dimer interface [polypeptide binding]; other site 481805006791 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 481805006792 Synaptic Flat tetramer interface [polypeptide binding]; other site 481805006793 Synaptic Site I dimer interface [polypeptide binding]; other site 481805006794 DNA binding site [nucleotide binding] 481805006795 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 481805006796 DNA-binding interface [nucleotide binding]; DNA binding site 481805006797 metabolite-proton symporter; Region: 2A0106; TIGR00883 481805006798 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805006799 putative substrate translocation pore; other site 481805006800 Mannitol-1-phosphate/altronate dehydrogenases [Carbohydrate transport and metabolism]; Region: MtlD; COG0246 481805006801 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 481805006802 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 481805006803 putative selenium-binding protein YdfZ; Region: YdfZ_fam; TIGR03318 481805006804 Transcriptional regulators [Transcription]; Region: GntR; COG1802 481805006805 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805006806 DNA-binding site [nucleotide binding]; DNA binding site 481805006807 FCD domain; Region: FCD; pfam07729 481805006808 malonic semialdehyde reductase; Provisional; Region: PRK10538 481805006809 classical (c) SDR, subgroup 5; Region: SDR_c5; cd05346 481805006810 putative NAD(P) binding site [chemical binding]; other site 481805006811 homodimer interface [polypeptide binding]; other site 481805006812 homotetramer interface [polypeptide binding]; other site 481805006813 active site 481805006814 dipeptidyl carboxypeptidase II; Provisional; Region: PRK10280 481805006815 Peptidase family M3 dipeptidyl carboxypeptidase (DCP); Region: M3A_DCP; cd06456 481805006816 active site 481805006817 Zn binding site [ion binding]; other site 481805006818 hypothetical protein; Validated; Region: PRK03657 481805006819 hypothetical protein; Provisional; Region: PRK10053 481805006820 diguanylate cyclase; Provisional; Region: PRK09894 481805006821 MCP-signal associated domain; Region: MCPsignal_assoc; pfam13682 481805006822 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805006823 metal binding site [ion binding]; metal-binding site 481805006824 active site 481805006825 I-site; other site 481805006826 putative transporter; Provisional; Region: PRK10054 481805006827 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805006828 putative substrate translocation pore; other site 481805006829 O-acetylserine/cysteine export protein; Provisional; Region: PRK11453 481805006830 EamA-like transporter family; Region: EamA; pfam00892 481805006831 EamA-like transporter family; Region: EamA; pfam00892 481805006832 hypothetical protein; Provisional; Region: PRK10106 481805006833 DNA-binding transcriptional activator MarA; Provisional; Region: PRK11511 481805006834 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805006835 DNA-binding transcriptional repressor MarR; Provisional; Region: PRK11512 481805006836 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481805006837 inner membrane protein; Provisional; Region: PRK10995 481805006838 putative arabinose transporter; Provisional; Region: PRK03545 481805006839 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805006840 putative substrate translocation pore; other site 481805006841 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481805006842 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805006843 The C-terminal substrate binding domain of LysR-type transcriptional regulators, YofA and SoxR, contains the type 2 periplasmic binding fold; Region: PBP2_YofA_SoxR_like; cd08442 481805006844 putative dimerization interface [polypeptide binding]; other site 481805006845 putative succinate semialdehyde dehydrogenase; Provisional; Region: PRK13968 481805006846 Mycobacterium tuberculosis succinate-semialdehyde dehydrogenase 1-like; Region: ALDH_SSADH1_GabD1; cd07100 481805006847 NAD(P) binding site [chemical binding]; other site 481805006848 catalytic residues [active] 481805006849 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 481805006850 glutaminase; Provisional; Region: PRK00971 481805006851 Domain of unknown function (DUF4186); Region: DUF4186; pfam13811 481805006852 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481805006853 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805006854 metal binding site [ion binding]; metal-binding site 481805006855 active site 481805006856 I-site; other site 481805006857 altronate oxidoreductase; Provisional; Region: PRK03643 481805006858 Mannitol dehydrogenase Rossmann domain; Region: Mannitol_dh; pfam01232 481805006859 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 481805006860 Predicted membrane protein [Function unknown]; Region: COG3781 481805006861 Trans-aconitate methyltransferase [General function prediction only]; Region: Tam; COG4106 481805006862 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805006863 S-adenosylmethionine binding site [chemical binding]; other site 481805006864 autoinducer-2 (AI-2) modifying protein LsrG; Provisional; Region: PRK10486 481805006865 DhnA-type fructose-1,6-bisphosphate aldolase and related enzymes [Carbohydrate transport and metabolism]; Region: FbaB; COG1830 481805006866 Class I fructose-1,6-bisphosphate (FBP) aldolases of the archaeal type (DhnA homologs); Region: DhnA; cd00958 481805006867 putative active site; other site 481805006868 catalytic residue [active] 481805006869 autoinducer 2-binding protein lsrB; Provisional; Region: PRK15408 481805006870 Periplasmic binding domain of autoinducer-2 (AI-2) receptor LsrB from Salmonella typhimurium and its close homologs; Region: PBP1_LsrB_Quorum_Sensing; cd06302 481805006871 ligand binding site [chemical binding]; other site 481805006872 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481805006873 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481805006874 TM-ABC transporter signature motif; other site 481805006875 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481805006876 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481805006877 TM-ABC transporter signature motif; other site 481805006878 autoinducer 2 ABC transporter ATP-binding protein LsrA; Provisional; Region: PRK15439 481805006879 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 481805006880 Walker A/P-loop; other site 481805006881 ATP binding site [chemical binding]; other site 481805006882 Q-loop/lid; other site 481805006883 ABC transporter signature motif; other site 481805006884 Walker B; other site 481805006885 D-loop; other site 481805006886 H-loop/switch region; other site 481805006887 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481805006888 transcriptional regulator LsrR; Provisional; Region: PRK15418 481805006889 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cl17320 481805006890 Putative sugar-binding domain; Region: Sugar-bind; pfam04198 481805006891 autoinducer-2 (AI-2) kinase; Provisional; Region: PRK10939 481805006892 Autoinducer-2 kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_AI-2K; cd07775 481805006893 putative N- and C-terminal domain interface [polypeptide binding]; other site 481805006894 putative active site [active] 481805006895 putative MgATP binding site [chemical binding]; other site 481805006896 catalytic site [active] 481805006897 metal binding site [ion binding]; metal-binding site 481805006898 putative carbohydrate binding site [chemical binding]; other site 481805006899 putative lipoprotein/autotransporter domain-containing protein; Provisional; Region: PRK14849 481805006900 Extended Signal Peptide of Type V secretion system; Region: ESPR; pfam13018 481805006901 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 2, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of the nonprotease autotransporters, Ag43; Region: PL2_Passenger_AT; cd01344 481805006902 Autotransporter beta-domain; Region: Autotransporter; pfam03797 481805006903 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 481805006904 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805006905 non-specific DNA binding site [nucleotide binding]; other site 481805006906 salt bridge; other site 481805006907 sequence-specific DNA binding site [nucleotide binding]; other site 481805006908 HipA N-terminal domain; Region: Couple_hipA; pfam13657 481805006909 Toxin module HipA, protein kinase of phosphatidylinositol 3/4-kinase superfamily [General function prediction only]; Region: HipA; COG3550 481805006910 HipA-like N-terminal domain; Region: HipA_N; pfam07805 481805006911 HipA-like C-terminal domain; Region: HipA_C; pfam07804 481805006912 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 481805006913 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 481805006914 PapC C-terminal domain; Region: PapC_C; pfam13953 481805006915 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 481805006916 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 481805006917 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 481805006918 mannosyl binding site [chemical binding]; other site 481805006919 Fimbrial protein; Region: Fimbrial; pfam00419 481805006920 putative oxidoreductase; Provisional; Region: PRK09939 481805006921 The MopB_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. These members belong to the molybdopterin_binding (MopB) superfamily of proteins; Region: MopB_ydeP; cd02767 481805006922 putative molybdopterin cofactor binding site [chemical binding]; other site 481805006923 The MopB_CT_ydeP CD includes a group of related uncharacterized bacterial molybdopterin-binding oxidoreductase-like domains with a putative molybdopterin cofactor binding site. This CD is of the conserved molybdopterin_binding C-terminal (MopB_CT) region...; Region: MopB_CT_ydeP; cd02787 481805006924 putative molybdopterin cofactor binding site; other site 481805006925 transcriptional regulator YdeO; Provisional; Region: PRK09940 481805006926 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805006927 Arylsulfatase A and related enzymes [Inorganic ion transport and metabolism]; Region: AslA; COG3119 481805006928 Sulfatase; Region: Sulfatase; pfam00884 481805006929 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 481805006930 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805006931 FeS/SAM binding site; other site 481805006932 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 481805006933 ABC-type uncharacterized transport system, permease and ATPase components [General function prediction only]; Region: COG4178 481805006934 ABC transporter transmembrane region 2; Region: ABC_membrane_2; cl00549 481805006935 ATP-binding cassette domain of peroxisomal transporter, subfamily D; Region: ABCD_peroxisomal_ALDP; cd03223 481805006936 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 481805006937 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 481805006938 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 481805006939 Insulinase (Peptidase family M16); Region: Peptidase_M16; pfam00675 481805006940 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 481805006941 Predicted Zn-dependent peptidases [General function prediction only]; Region: PqqL; COG0612 481805006942 Peptidase M16 inactive domain; Region: Peptidase_M16_C; pfam05193 481805006943 DOPA decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to DOPA/tyrosine decarboxylase (DDC), histidine decarboxylase (HDC), and...; Region: DOPA_deC_like; cd06450 481805006944 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805006945 catalytic residue [active] 481805006946 glutamate:gamma-aminobutyrate antiporter; Region: 2A0307_GadC; TIGR00910 481805006947 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1649 481805006948 Uncharacterized BCR, COG1649; Region: DUF187; pfam02638 481805006949 Globin domain present in Globin-Coupled-Sensors (GCS). These domains detect changes in intracellular concentrations of oxygen, carbon monoxyde, or nitrous oxide, which result in aerotaxis and/or gene regulation. One subgroup, the HemATs, are aerotactic...; Region: sensor_globin; cd01068 481805006950 heme-binding site [chemical binding]; other site 481805006951 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481805006952 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805006953 metal binding site [ion binding]; metal-binding site 481805006954 active site 481805006955 I-site; other site 481805006956 cyclic-di-GMP phosphodiesterase; Provisional; Region: PRK11359 481805006957 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481805006958 putative active site [active] 481805006959 heme pocket [chemical binding]; other site 481805006960 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481805006961 putative active site [active] 481805006962 heme pocket [chemical binding]; other site 481805006963 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805006964 metal binding site [ion binding]; metal-binding site 481805006965 active site 481805006966 I-site; other site 481805006967 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805006968 D-alanyl-D-alanine dipeptidase; Provisional; Region: PRK10178 481805006969 ABC-type dipeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: DdpA; COG0747 481805006970 The substrate-binding component of an uncharacterized ABC-type nickel/dipeptide/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like_7; cd08512 481805006971 ABC-type dipeptide/oligopeptide/nickel transport systems, permease components [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppB; COG0601 481805006972 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805006973 dimer interface [polypeptide binding]; other site 481805006974 conserved gate region; other site 481805006975 putative PBP binding loops; other site 481805006976 ABC-ATPase subunit interface; other site 481805006977 D-ala-D-ala transporter subunit; Provisional; Region: PRK09881 481805006978 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 481805006979 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805006980 dimer interface [polypeptide binding]; other site 481805006981 conserved gate region; other site 481805006982 putative PBP binding loops; other site 481805006983 ABC-ATPase subunit interface; other site 481805006984 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppD; COG0444 481805006985 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805006986 Walker A/P-loop; other site 481805006987 ATP binding site [chemical binding]; other site 481805006988 Q-loop/lid; other site 481805006989 ABC transporter signature motif; other site 481805006990 Walker B; other site 481805006991 D-loop; other site 481805006992 H-loop/switch region; other site 481805006993 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 481805006994 ABC-type dipeptide/oligopeptide/nickel transport system, ATPase component [Amino acid transport and metabolism / Inorganic ion transport and metabolism]; Region: DppF; COG1124 481805006995 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805006996 Walker A/P-loop; other site 481805006997 ATP binding site [chemical binding]; other site 481805006998 Q-loop/lid; other site 481805006999 ABC transporter signature motif; other site 481805007000 Walker B; other site 481805007001 D-loop; other site 481805007002 H-loop/switch region; other site 481805007003 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 481805007004 peroxiredoxin, OsmC subfamily; Region: osmo_induc_OsmC; TIGR03562 481805007005 Putative biofilm-dependent modulation protein; Region: BDM; cl11581 481805007006 30S ribosomal subunit S22; Reviewed; Region: rpsV; PRK10057 481805007007 malate dehydrogenase; Provisional; Region: PRK13529 481805007008 Malic enzyme, N-terminal domain; Region: malic; pfam00390 481805007009 NAD(P) binding domain of malic enzyme (ME), subgroup 1; Region: NAD_bind_1_malic_enz; cd05312 481805007010 NAD(P) binding site [chemical binding]; other site 481805007011 ethanol-active dehydrogenase/acetaldehyde-active reductase; Provisional; Region: PRK09422 481805007012 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD3; cd08297 481805007013 NAD binding site [chemical binding]; other site 481805007014 substrate binding site [chemical binding]; other site 481805007015 catalytic Zn binding site [ion binding]; other site 481805007016 tetramer interface [polypeptide binding]; other site 481805007017 structural Zn binding site [ion binding]; other site 481805007018 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 481805007019 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805007020 non-specific DNA binding site [nucleotide binding]; other site 481805007021 salt bridge; other site 481805007022 sequence-specific DNA binding site [nucleotide binding]; other site 481805007023 formate dehydrogenase-N subunit gamma; Provisional; Region: PRK10179 481805007024 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 481805007025 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 481805007026 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 481805007027 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 481805007028 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 481805007029 [4Fe-4S] binding site [ion binding]; other site 481805007030 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 481805007031 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 481805007032 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 481805007033 molybdopterin cofactor binding site; other site 481805007034 aromatic amino acid exporter; Provisional; Region: PRK11689 481805007035 Porin superfamily. These outer membrane channels share a beta-barrel structure that differ in strand and shear number. Classical (gram-negative ) porins are non-specific channels for small hydrophillic molecules and form 16 beta-stranded barrels (16,20)...; Region: OM_channels; cl17244 481805007036 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 481805007037 Leucine-rich repeat (LRR) protein [Function unknown]; Region: COG4886 481805007038 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 481805007039 Nitrate reductase alpha subunit [Energy production and conversion]; Region: NarG; COG5013 481805007040 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 481805007041 [4Fe-4S] binding site [ion binding]; other site 481805007042 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 481805007043 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 481805007044 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 481805007045 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 481805007046 molybdopterin cofactor binding site; other site 481805007047 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 481805007048 nitrate reductase 2 subunit delta; Provisional; Region: PRK15054 481805007049 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 481805007050 hypothetical protein; Provisional; Region: PRK10281 481805007051 N-hydroxyarylamine O-acetyltransferase; Provisional; Region: PRK15047 481805007052 Conserved protein/domain typically associated with flavoprotein oxygenases, DIM6/NTAB family [General function prediction only]; Region: COG1853 481805007053 4-oxalocrotonate tautomerase; Provisional; Region: PRK01271 481805007054 active site 1 [active] 481805007055 dimer interface [polypeptide binding]; other site 481805007056 hexamer interface [polypeptide binding]; other site 481805007057 active site 2 [active] 481805007058 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 481805007059 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 481805007060 Transposase [DNA replication, recombination, and repair]; Region: COG5433 481805007061 RT_G2_intron: Reverse transcriptases (RTs) with group II intron origin. RT transcribes DNA using RNA as template. Proteins in this subfamily are found in bacterial and mitochondrial group II introns. Their most probable ancestor was a retrotransposable...; Region: RT_G2_intron; cd01651 481805007062 Reverse transcriptase (RNA-dependent DNA polymerase); Region: RVT_1; pfam00078 481805007063 putative active site [active] 481805007064 putative NTP binding site [chemical binding]; other site 481805007065 putative nucleic acid binding site [nucleotide binding]; other site 481805007066 Group II intron, maturase-specific domain; Region: GIIM; pfam08388 481805007067 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805007068 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805007069 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805007070 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805007071 PAAR motif; Region: PAAR_motif; cl15808 481805007072 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805007073 RHS Repeat; Region: RHS_repeat; pfam05593 481805007074 RHS Repeat; Region: RHS_repeat; pfam05593 481805007075 RHS Repeat; Region: RHS_repeat; pfam05593 481805007076 RHS Repeat; Region: RHS_repeat; pfam05593 481805007077 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805007078 RHS Repeat; Region: RHS_repeat; pfam05593 481805007079 RHS Repeat; Region: RHS_repeat; pfam05593 481805007080 RHS protein; Region: RHS; pfam03527 481805007081 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 481805007082 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 481805007083 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 481805007084 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 481805007085 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 481805007086 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 481805007087 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 481805007088 Transposase [DNA replication, recombination, and repair]; Region: COG5433 481805007089 Transposase [DNA replication, recombination, and repair]; Region: COG5433 481805007090 GST_N family, Class Beta subfamily; GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of endogenous and xenobiotic alkylating agents, including carcinogens; Region: GST_N_Beta; cd03057 481805007091 C-terminal domain interface [polypeptide binding]; other site 481805007092 GSH binding site (G-site) [chemical binding]; other site 481805007093 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 481805007094 dimer interface [polypeptide binding]; other site 481805007095 C-terminal, alpha helical domain of Class Beta Glutathione S-transferases; Region: GST_C_Beta; cd03188 481805007096 dimer interface [polypeptide binding]; other site 481805007097 N-terminal domain interface [polypeptide binding]; other site 481805007098 substrate binding pocket (H-site) [chemical binding]; other site 481805007099 L-asparagine permease; Provisional; Region: PRK15049 481805007100 PQQ-like domain; Region: PQQ_2; pfam13360 481805007101 Outer membrane receptor proteins, mostly Fe transport [Inorganic ion transport and metabolism]; Region: CirA; COG1629 481805007102 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 481805007103 N-terminal plug; other site 481805007104 ligand-binding site [chemical binding]; other site 481805007105 colanic acid/biofilm transcriptional regulator; Provisional; Region: PRK11414 481805007106 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805007107 DNA-binding site [nucleotide binding]; DNA binding site 481805007108 FCD domain; Region: FCD; pfam07729 481805007109 Putative NADP-dependent oxidoreductases [General function prediction only]; Region: COG2130 481805007110 Prostaglandin dehydrogenases; Region: PGDH; cd05288 481805007111 NAD(P) binding site [chemical binding]; other site 481805007112 substrate binding site [chemical binding]; other site 481805007113 dimer interface [polypeptide binding]; other site 481805007114 Sortase and related acyltransferases [Cell envelope biogenesis, outer membrane]; Region: COG1247 481805007115 Acetyltransferase (GNAT) family; Region: Acetyltransf_1; pfam00583 481805007116 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3238 481805007117 Protein of unknown function (DUF2526); Region: DUF2526; pfam10735 481805007118 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 481805007119 gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK13473 481805007120 Escherichia coli NAD+-dependent gamma-aminobutyraldehyde dehydrogenase YdcW-like; Region: ALDH_ABALDH-YdcW; cd07092 481805007121 tetrameric interface [polypeptide binding]; other site 481805007122 NAD binding site [chemical binding]; other site 481805007123 catalytic residues [active] 481805007124 substrate binding site [chemical binding]; other site 481805007125 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 481805007126 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805007127 ABC-ATPase subunit interface; other site 481805007128 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805007129 dimer interface [polypeptide binding]; other site 481805007130 conserved gate region; other site 481805007131 putative PBP binding loops; other site 481805007132 ABC-ATPase subunit interface; other site 481805007133 ABC-type spermidine/putrescine transport systems, ATPase components [Amino acid transport and metabolism]; Region: PotA; COG3842 481805007134 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805007135 Walker A/P-loop; other site 481805007136 ATP binding site [chemical binding]; other site 481805007137 Q-loop/lid; other site 481805007138 ABC transporter signature motif; other site 481805007139 Walker B; other site 481805007140 D-loop; other site 481805007141 H-loop/switch region; other site 481805007142 TOBE domain; Region: TOBE_2; pfam08402 481805007143 Bacterial extracellular solute-binding protein; Region: SBP_bac_8; pfam13416 481805007144 ABC-type Fe3+ transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: AfuA; COG1840 481805007145 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 481805007146 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805007147 DNA-binding site [nucleotide binding]; DNA binding site 481805007148 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481805007149 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805007150 homodimer interface [polypeptide binding]; other site 481805007151 catalytic residue [active] 481805007152 Predicted nuclease of the RNAse H fold, HicB family [General function prediction only]; Region: COG1598 481805007153 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805007154 sequence-specific DNA binding site [nucleotide binding]; other site 481805007155 salt bridge; other site 481805007156 YcfA-like protein; Region: YcfA; pfam07927 481805007157 Protein of unknown function (DUF2554); Region: DUF2554; pfam10829 481805007158 TIM barrel proteins share a structurally conserved phosphate binding motif and in general share an eight beta/alpha closed barrel structure. Specific for this family is the conserved phosphate binding site at the edges of strands 7 and 8. The phosphate...; Region: TIM_phosphate_binding; cl17186 481805007159 Collagenase and related proteases [Posttranslational modification, protein turnover, chaperones]; Region: COG0826 481805007160 Peptidase family U32; Region: Peptidase_U32; pfam01136 481805007161 Collagenase; Region: DUF3656; pfam12392 481805007162 Predicted transcriptional regulators [Transcription]; Region: HipB; COG1396 481805007163 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805007164 non-specific DNA binding site [nucleotide binding]; other site 481805007165 salt bridge; other site 481805007166 sequence-specific DNA binding site [nucleotide binding]; other site 481805007167 Cupin domain; Region: Cupin_2; pfam07883 481805007168 Uncharacterized protein involved in benzoate metabolism [Secondary metabolites biosynthesis, transport, and catabolism]; Region: BenE; COG3135 481805007169 benzoate transporter; Region: benE; TIGR00843 481805007170 Helix-turn-helix domain; Region: HTH_OrfB_IS605; pfam12323 481805007171 Probable transposase; Region: OrfB_IS605; pfam01385 481805007172 transposase, IS605 OrfB family, central region; Region: tspaseT_teng_C; TIGR01766 481805007173 Putative transposase DNA-binding domain; Region: OrfB_Zn_ribbon; pfam07282 481805007174 Protein of unknown function (DUF3313); Region: DUF3313; pfam11769 481805007175 tellurite resistance protein TehB; Provisional; Region: PRK11207 481805007176 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805007177 S-adenosylmethionine binding site [chemical binding]; other site 481805007178 Tellurite resistance protein and related permeases [Inorganic ion transport and metabolism]; Region: TehA; COG1275 481805007179 Tellurite-resistance/Dicarboxylate Transporter (TDT) family includes TehA protein; Region: TDT_TehA; cd09324 481805007180 gating phenylalanine in ion channel; other site 481805007181 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 481805007182 putative trimer interface [polypeptide binding]; other site 481805007183 putative CoA binding site [chemical binding]; other site 481805007184 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cd00208 481805007185 putative trimer interface [polypeptide binding]; other site 481805007186 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 481805007187 putative CoA binding site [chemical binding]; other site 481805007188 putative trimer interface [polypeptide binding]; other site 481805007189 putative CoA binding site [chemical binding]; other site 481805007190 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481805007191 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481805007192 Coenzyme A binding pocket [chemical binding]; other site 481805007193 hypothetical protein; Provisional; Region: PRK11415 481805007194 Periplasmic glucans biosynthesis protein [Inorganic ion transport and metabolism]; Region: MdoG; COG3131 481805007195 glucan biosynthesis protein D; Provisional; Region: mdoD; PRK13273 481805007196 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 481805007197 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5383 481805007198 pca operon transcription factor PcaQ; Region: TF_pcaQ; TIGR02424 481805007199 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805007200 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481805007201 dimerization interface [polypeptide binding]; other site 481805007202 methyl-accepting chemotaxis protein II; Provisional; Region: PRK15048 481805007203 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 481805007204 dimer interface [polypeptide binding]; other site 481805007205 ligand binding site [chemical binding]; other site 481805007206 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805007207 dimerization interface [polypeptide binding]; other site 481805007208 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481805007209 dimer interface [polypeptide binding]; other site 481805007210 putative CheW interface [polypeptide binding]; other site 481805007211 small toxic polypeptide; Provisional; Region: PRK09738 481805007212 hypothetical protein; Provisional; Region: PRK10040 481805007213 cytochrome b561; Provisional; Region: PRK11513 481805007214 glyceraldehyde-3-phosphate dehydrogenase, type I; Region: GAPDH-I; TIGR01534 481805007215 Glyceraldehyde 3-phosphate dehydrogenase, NAD binding domain; Region: Gp_dh_N; smart00846 481805007216 Glyceraldehyde 3-phosphate dehydrogenase, C-terminal domain; Region: Gp_dh_C; pfam02800 481805007217 Escherichia coli lactaldehyde dehydrogenase AldA-like; Region: ALDH_LactADH-AldA; cd07088 481805007218 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 481805007219 NAD binding site [chemical binding]; other site 481805007220 catalytic residues [active] 481805007221 substrate binding site [chemical binding]; other site 481805007222 Uncharacterized conserved protein [Function unknown]; Region: COG1434 481805007223 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 481805007224 putative active site [active] 481805007225 ATP-dependent RNA helicase HrpA; Provisional; Region: PRK11131 481805007226 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481805007227 ATP binding site [chemical binding]; other site 481805007228 putative Mg++ binding site [ion binding]; other site 481805007229 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805007230 nucleotide binding region [chemical binding]; other site 481805007231 ATP-binding site [chemical binding]; other site 481805007232 Helicase associated domain (HA2); Region: HA2; pfam04408 481805007233 Oligonucleotide/oligosaccharide-binding (OB)-fold; Region: OB_NTP_bind; pfam07717 481805007234 Domain of unknown function (DUF3418); Region: DUF3418; pfam11898 481805007235 azoreductase; Reviewed; Region: PRK00170 481805007236 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481805007237 PAP2_like proteins, Aur1_like subfamily. Yeast Aur1p or Ipc1p is necessary for the addition of inositol phosphate to ceramide, an essential step in yeast sphingolipid synthesis, and is the target of several antifungal compounds such as aureobasidin; Region: PAP2_Aur1_like; cd03386 481805007238 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 481805007239 active site 481805007240 Dual specificity phosphatases (DSP); Ser/Thr and Tyr protein phosphatases. Structurally similar to tyrosine-specific phosphatases but with a shallower active site cleft and a distinctive active site signature motif, HCxxGxxR. Characterized as VHR- or...; Region: DSPc; cd00127 481805007241 active site 481805007242 catalytic residues [active] 481805007243 Lysophospholipase [Lipid metabolism]; Region: PldB; COG2267 481805007244 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 481805007245 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805007246 S-adenosylmethionine binding site [chemical binding]; other site 481805007247 Predicted CDP-diglyceride synthetase/phosphatidate cytidylyltransferase [General function prediction only]; Region: COG4589 481805007248 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 481805007249 Phosphatidylglycerophosphate synthase [Lipid metabolism]; Region: PgsA; COG0558 481805007250 Polymer-forming cytoskeletal; Region: Bactofilin; pfam04519 481805007251 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 481805007252 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481805007253 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481805007254 active site 481805007255 catalytic tetrad [active] 481805007256 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 481805007257 Helix-turn-helix domain; Region: HTH_38; pfam13936 481805007258 Integrase core domain; Region: rve; pfam00665 481805007259 phenylacetic acid degradation protein PaaY; Region: PaaY; TIGR02287 481805007260 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 481805007261 putative trimer interface [polypeptide binding]; other site 481805007262 putative metal binding site [ion binding]; other site 481805007263 PaaX-like protein; Region: PaaX; pfam07848 481805007264 phenylacetic acid degradation operon negative regulatory protein PaaX; Region: PaaX_trns_reg; TIGR02277 481805007265 PaaX-like protein C-terminal domain; Region: PaaX_C; pfam08223 481805007266 Phenylacetate-CoA ligase (also known as PaaK); Region: PaaK; cd05913 481805007267 phenylacetate-CoA ligase; Region: PA_CoA_ligase; TIGR02155 481805007268 active site 481805007269 AMP binding site [chemical binding]; other site 481805007270 homodimer interface [polypeptide binding]; other site 481805007271 acyl-activating enzyme (AAE) consensus motif; other site 481805007272 CoA binding site [chemical binding]; other site 481805007273 beta-ketoadipyl CoA thiolase; Validated; Region: PRK09050 481805007274 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 481805007275 dimer interface [polypeptide binding]; other site 481805007276 active site 481805007277 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 481805007278 CoenzymeA binding site [chemical binding]; other site 481805007279 subunit interaction site [polypeptide binding]; other site 481805007280 PHB binding site; other site 481805007281 3-hydroxyacyl-CoA dehydrogenase PaaC; Region: PaaC-3OHAcCoADH; TIGR02279 481805007282 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 481805007283 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 481805007284 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 481805007285 enoyl-CoA hydratase; Provisional; Region: PRK08140 481805007286 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 481805007287 substrate binding site [chemical binding]; other site 481805007288 oxyanion hole (OAH) forming residues; other site 481805007289 trimer interface [polypeptide binding]; other site 481805007290 enoyl-CoA hydratase-isomerase; Provisional; Region: PRK09674 481805007291 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 481805007292 substrate binding site [chemical binding]; other site 481805007293 oxyanion hole (OAH) forming residues; other site 481805007294 trimer interface [polypeptide binding]; other site 481805007295 phenylacetate-CoA oxygenase/reductase, PaaK subunit; Region: PA_CoA_Oxy5; TIGR02160 481805007296 NAD(P) binding domain of ferredoxin reductase like phenylacetic acid (PA) degradation oxidoreductase. PA oxidoreductases of E. coli hydroxylate PA-CoA in the second step of PA degradation. Members of this group typically fuse a ferredoxin reductase-like...; Region: PA_degradation_oxidoreductase_like; cd06214 481805007297 FAD binding pocket [chemical binding]; other site 481805007298 FAD binding motif [chemical binding]; other site 481805007299 phosphate binding motif [ion binding]; other site 481805007300 beta-alpha-beta structure motif; other site 481805007301 NAD(p) ribose binding residues [chemical binding]; other site 481805007302 NAD binding pocket [chemical binding]; other site 481805007303 NAD(P)-pyrophosphate-nicotinamide binding residues [chemical binding]; other site 481805007304 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 481805007305 catalytic loop [active] 481805007306 iron binding site [ion binding]; other site 481805007307 Predicted metal-sulfur cluster biosynthetic enzyme [General function prediction only]; Region: PaaD; COG2151 481805007308 phenylacetate-CoA oxygenase, PaaJ subunit; Region: PA_CoA_Oxy4; TIGR02159 481805007309 phenylacetate-CoA oxygenase, PaaI subunit; Region: PA_CoA_Oxy3; TIGR02158 481805007310 phenylacetate-CoA oxygenase subunit PaaB; Provisional; Region: paaB; PRK13781 481805007311 phenylacetate-CoA oxygenase subunit PaaA; Provisional; Region: paaA; PRK13778 481805007312 phenylacetate-CoA oxygenase, PaaG subunit; Region: PA_CoA_Oxy1; TIGR02156 481805007313 bifunctional aldehyde dehydrogenase/enoyl-CoA hydratase; Provisional; Region: PRK11563 481805007314 N-terminal domain of the monoamine oxidase C dehydratase; Region: ALDH_MaoC-N; cd07128 481805007315 substrate binding site [chemical binding]; other site 481805007316 dimer interface [polypeptide binding]; other site 481805007317 NADP binding site [chemical binding]; other site 481805007318 catalytic residues [active] 481805007319 MaoC_C The C-terminal hot dog fold of the MaoC (monoamine oxidase C) dehydratase regulatory protein. Orthologs of MaoC include PaaZ [Escherichia coli] and PaaN [Pseudomonas putida], which are putative ring-opening enzymes involved in phenylacetic acid...; Region: MaoC_C; cd03452 481805007320 substrate binding site [chemical binding]; other site 481805007321 tyramine oxidase; Provisional; Region: tynA; PRK14696 481805007322 Copper amine oxidase N-terminal domain; Region: Cu_amine_oxidN1; pfam07833 481805007323 Copper amine oxidase, N2 domain; Region: Cu_amine_oxidN2; pfam02727 481805007324 Copper amine oxidase, N3 domain; Region: Cu_amine_oxidN3; pfam02728 481805007325 Copper amine oxidase, enzyme domain; Region: Cu_amine_oxid; pfam01179 481805007326 NAD(P)+-dependent aldehyde dehydrogenase superfamily; Region: ALDH-SF; cl11961 481805007327 Aldehyde dehydrogenase family; Region: Aldedh; pfam00171 481805007328 NAD(P) binding site [chemical binding]; other site 481805007329 catalytic residues [active] 481805007330 DNA-binding transcriptional activator FeaR; Provisional; Region: PRK09685 481805007331 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805007332 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3784 481805007333 YnbE-like lipoprotein; Region: Lipoprotein_19; pfam13617 481805007334 hypothetical protein; Provisional; Region: PRK10695 481805007335 D-Lactate and related Dehydrogenases, NAD-binding and catalytic domains; Region: LDH_like_2; cd12183 481805007336 Lactate dehydrogenase and related dehydrogenases [Energy production and conversion / Coenzyme metabolism / General function prediction only]; Region: LdhA; COG1052 481805007337 putative ligand binding site [chemical binding]; other site 481805007338 putative NAD binding site [chemical binding]; other site 481805007339 catalytic site [active] 481805007340 heat-inducible protein; Provisional; Region: PRK10449 481805007341 Putative hemolysin [General function prediction only]; Region: Hlx; COG3042 481805007342 Domain of unknown function (DUF333); Region: DUF333; pfam03891 481805007343 pyruvate:ferredoxin (flavodoxin) oxidoreductase, homodimeric; Region: pyruv_ox_red; TIGR02176 481805007344 Pyrimidine (PYR) binding domain of pyruvate ferredoxin oxidoreductase (PFOR), indolepyruvate ferredoxin oxidoreductase alpha subunit (IOR-alpha), and related proteins; Region: TPP_PYR_PFOR_IOR-alpha_like; cd07034 481805007345 dimer interface [polypeptide binding]; other site 481805007346 PYR/PP interface [polypeptide binding]; other site 481805007347 TPP binding site [chemical binding]; other site 481805007348 substrate binding site [chemical binding]; other site 481805007349 Pyruvate:ferredoxin oxidoreductase and related 2-oxoacid:ferredoxin oxidoreductases, gamma subunit [Energy production and conversion]; Region: PorG; COG1014 481805007350 Domain of unknown function; Region: EKR; smart00890 481805007351 4Fe-4S binding domain; Region: Fer4_6; pfam12837 481805007352 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 481805007353 Thiamine pyrophosphate (TPP family), PFOR_PNO subfamily, TPP-binding module; composed of proteins similar to the single subunit pyruvate ferredoxin oxidoreductase (PFOR) of Desulfovibrio Africanus, present in bacteria and amitochondriate eukaryotes. This...; Region: TPP_PFOR_PNO; cd03377 481805007354 TPP-binding site [chemical binding]; other site 481805007355 dimer interface [polypeptide binding]; other site 481805007356 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 481805007357 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 481805007358 trimer interface [polypeptide binding]; other site 481805007359 eyelet of channel; other site 481805007360 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 481805007361 Ligand Binding Site [chemical binding]; other site 481805007362 tRNA 2-thiocytidine biosynthesis protein TtcA; Provisional; Region: PRK10696 481805007363 This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases superfamily includes N type ATP PPases and ATP sulphurylases. It forms a apha/beta/apha fold which binds to Adenosine group. This subfamily; Region: Alpha_ANH_like_II; cd01993 481805007364 Ligand Binding Site [chemical binding]; other site 481805007365 ATP-dependent RNA helicase DbpA; Provisional; Region: PRK11776 481805007366 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 481805007367 ATP binding site [chemical binding]; other site 481805007368 Mg++ binding site [ion binding]; other site 481805007369 motif III; other site 481805007370 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805007371 nucleotide binding region [chemical binding]; other site 481805007372 ATP-binding site [chemical binding]; other site 481805007373 RNA recognition motif in Escherichia coli RNA helicase dbpA and similar proteins; Region: RRM_EcDbpA_like; cd12501 481805007374 putative RNA binding site [nucleotide binding]; other site 481805007375 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 481805007376 Salmonella typhimurium Zn2+ transporter ZntB-like subgroup; Region: ZntB-like_1; cd12833 481805007377 Cl binding site [ion binding]; other site 481805007378 oligomer interface [polypeptide binding]; other site 481805007379 PAS domain S-box; Region: sensory_box; TIGR00229 481805007380 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481805007381 putative active site [active] 481805007382 heme pocket [chemical binding]; other site 481805007383 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481805007384 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805007385 metal binding site [ion binding]; metal-binding site 481805007386 active site 481805007387 I-site; other site 481805007388 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2840 481805007389 Smr domain; Region: Smr; pfam01713 481805007390 putative DNA-binding transcriptional regulator; Provisional; Region: PRK09791 481805007391 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805007392 The C-terminal substrate binding domain of LysR-type transcriptional regulator TdcA, which is involved in the degradation of L-serine and L-threonine, contains the type 2 periplasmic binding fold; Region: PBP2_TdcA; cd08418 481805007393 putative substrate binding pocket [chemical binding]; other site 481805007394 putative dimerization interface [polypeptide binding]; other site 481805007395 M20 Peptidases Aminoacyclase-1 indole-3-acetic-L-aspartic acid hydrolase from bacteria and archaea; Region: M20_Acy1_IAAspH_bact; cd05665 481805007396 amidohydrolase; Region: amidohydrolases; TIGR01891 481805007397 putative metal binding site [ion binding]; other site 481805007398 dimer interface [polypeptide binding]; other site 481805007399 M20 Peptidase Aminoacylase 1-like protein 2 aminobenzoyl-glutamate utilization protein B subfamily; Region: M20_Acy1L2_AbgB; cd05673 481805007400 amidohydrolase; Region: amidohydrolases; TIGR01891 481805007401 putative metal binding site [ion binding]; other site 481805007402 putative aminobenzoyl-glutamate transporter; Provisional; Region: abgT; PRK11339 481805007403 p-Aminobenzoyl-glutamate transporter family; Region: ydaH; TIGR00819 481805007404 O-6-alkylguanine-DNA:cysteine-protein methyltransferase; Provisional; Region: PRK10286 481805007405 6-O-methylguanine DNA methyltransferase, ribonuclease-like domain; Region: Methyltransf_1N; pfam02870 481805007406 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 481805007407 DNA binding site [nucleotide binding] 481805007408 active site 481805007409 fumarate/nitrate reduction transcriptional regulator; Provisional; Region: PRK11161 481805007410 effector domain of the CAP family of transcription factors; members include CAP (or cAMP receptor protein (CRP)), which binds cAMP, FNR (fumarate and nitrate reduction), which uses an iron-sulfur cluster to sense oxygen) and CooA, a heme containing CO...; Region: CAP_ED; cd00038 481805007411 ligand binding site [chemical binding]; other site 481805007412 flexible hinge region; other site 481805007413 helix_turn_helix, cAMP Regulatory protein C-terminus; DNA binding domain of prokaryotic regulatory proteins belonging to the catabolite activator protein family; Region: HTH_CRP; cd00092 481805007414 putative switch regulator; other site 481805007415 non-specific DNA interactions [nucleotide binding]; other site 481805007416 DNA binding site [nucleotide binding] 481805007417 sequence specific DNA binding site [nucleotide binding]; other site 481805007418 putative cAMP binding site [chemical binding]; other site 481805007419 universal stress protein UspE; Provisional; Region: PRK11175 481805007420 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 481805007421 Ligand Binding Site [chemical binding]; other site 481805007422 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 481805007423 Ligand Binding Site [chemical binding]; other site 481805007424 Protein of unknown function (DUF2534); Region: DUF2534; pfam10749 481805007425 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 481805007426 Mechanosensitive ion channel; Region: MS_channel; pfam00924 481805007427 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 481805007428 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 481805007429 peptide binding site [polypeptide binding]; other site 481805007430 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481805007431 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805007432 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 481805007433 putative effector binding pocket; other site 481805007434 putative dimerization interface [polypeptide binding]; other site 481805007435 Hydrolases of the alpha/beta superfamily [General function prediction only]; Region: COG1073 481805007436 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481805007437 Predicted carboxypeptidase [Amino acid transport and metabolism]; Region: COG2866 481805007438 Peptidase M14-like domain of Escherichia coli Murein Peptide Amidase A and related proteins; Region: M14_MpaA_like; cd06904 481805007439 putative active site [active] 481805007440 Zn binding site [ion binding]; other site 481805007441 L-Ala-D/L-Glu epimerase; Provisional; Region: PRK15129 481805007442 L-Ala-D/L-Glu epimerase catalyzes the epimerization of L-Ala-D/L-Glu and other dipeptides. The genomic context and the substrate specificity of characterized members of this family from E.coli and B.subtilis indicates a possible role in the metabolism of...; Region: L-Ala-DL-Glu_epimerase; cd03319 481805007443 active site 481805007444 Peroxiredoxin (PRX) family, Atypical 2-cys PRX subfamily; composed of PRXs containing peroxidatic and resolving cysteines, similar to the homodimeric thiol specific antioxidant (TSA) protein also known as TRX-dependent thiol peroxidase (Tpx). Tpx is a...; Region: PRX_Atyp2cys; cd03014 481805007445 dimer interface [polypeptide binding]; other site 481805007446 catalytic triad [active] 481805007447 peroxidatic and resolving cysteines [active] 481805007448 DNA-binding transcriptional regulator TyrR; Provisional; Region: PRK10820 481805007449 N-terminal ACT domain of the TyrR protein; Region: ACT_TyrR; cd04877 481805007450 putative aromatic amino acid binding site; other site 481805007451 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805007452 Walker A motif; other site 481805007453 ATP binding site [chemical binding]; other site 481805007454 Walker B motif; other site 481805007455 arginine finger; other site 481805007456 hypothetical protein; Provisional; Region: PRK05415 481805007457 TIGR01620 family protein; Region: hyp_HI0043 481805007458 Predicted ATPase [General function prediction only]; Region: COG3106 481805007459 Transcriptional regulators [Transcription]; Region: PurR; COG1609 481805007460 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481805007461 DNA binding site [nucleotide binding] 481805007462 domain linker motif; other site 481805007463 Ligand-binding domain of uncharacterized transcription regulator ycjW which is a member of the LacI-GalR family repressors; Region: PBP1_ycjW_transcription_regulator_like; cd06294 481805007464 putative dimerization interface [polypeptide binding]; other site 481805007465 putative ligand binding site [chemical binding]; other site 481805007466 Outer membrane protein G (OmpG); Region: Porin_OmpG; pfam09381 481805007467 ABC-type sugar transport systems, ATPase components [Carbohydrate transport and metabolism]; Region: MalK; COG3839 481805007468 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 481805007469 Walker A/P-loop; other site 481805007470 ATP binding site [chemical binding]; other site 481805007471 Q-loop/lid; other site 481805007472 ABC transporter signature motif; other site 481805007473 Walker B; other site 481805007474 D-loop; other site 481805007475 H-loop/switch region; other site 481805007476 TOBE domain; Region: TOBE_2; pfam08402 481805007477 beta-phosphoglucomutase; Region: bPGM; TIGR01990 481805007478 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805007479 motif II; other site 481805007480 Trehalose and maltose hydrolases (possible phosphorylases) [Carbohydrate transport and metabolism]; Region: ATH1; COG1554 481805007481 Glycosyl hydrolase family 65, N-terminal domain; Region: Glyco_hydro_65N; pfam03636 481805007482 Glycosyl hydrolase family 65 central catalytic domain; Region: Glyco_hydro_65m; pfam03632 481805007483 Glycosyl hydrolase family 65, C-terminal domain; Region: Glyco_hydro_65C; pfam03633 481805007484 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481805007485 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481805007486 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481805007487 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 481805007488 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 481805007489 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide and other MDR family members; Region: 2-desacetyl-2-hydroxyethyl_bacteriochlorophyllide_; cd08255 481805007490 putative NAD(P) binding site [chemical binding]; other site 481805007491 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481805007492 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805007493 dimer interface [polypeptide binding]; other site 481805007494 conserved gate region; other site 481805007495 putative PBP binding loops; other site 481805007496 ABC-ATPase subunit interface; other site 481805007497 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 481805007498 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805007499 dimer interface [polypeptide binding]; other site 481805007500 conserved gate region; other site 481805007501 putative PBP binding loops; other site 481805007502 ABC-ATPase subunit interface; other site 481805007503 ABC-type sugar transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: UgpB; COG1653 481805007504 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481805007505 Alpha amylase catalytic domain found in sucrose phosphorylase-like proteins (also called sucrose glucosyltransferase, disaccharide glucosyltransferase, and sucrose-phosphate alpha-D glucosyltransferase); Region: AmyAc_Sucrose_phosphorylase-like_1; cd11356 481805007506 sucrose phosphorylase; Provisional; Region: PRK13840 481805007507 active site 481805007508 homodimer interface [polypeptide binding]; other site 481805007509 catalytic site [active] 481805007510 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 481805007511 active site residue [active] 481805007512 peripheral inner membrane phage-shock protein; Provisional; Region: PRK10497 481805007513 DNA-binding transcriptional activator PspC; Provisional; Region: PRK10697 481805007514 phage shock protein C; Region: phageshock_pspC; TIGR02978 481805007515 phage shock protein B; Provisional; Region: pspB; PRK09458 481805007516 phage shock protein PspA; Provisional; Region: PRK10698 481805007517 phage shock protein operon transcriptional activator; Provisional; Region: pspF; PRK11608 481805007518 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805007519 Walker A motif; other site 481805007520 ATP binding site [chemical binding]; other site 481805007521 Walker B motif; other site 481805007522 arginine finger; other site 481805007523 4-aminobutyrate transaminase; Provisional; Region: PRK09792 481805007524 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 481805007525 inhibitor-cofactor binding pocket; inhibition site 481805007526 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805007527 catalytic residue [active] 481805007528 putative aminophosphonate oxidoreductase; Region: Phn_aa_oxid; TIGR03329 481805007529 Glycine/D-amino acid oxidases (deaminating) [Amino acid transport and metabolism]; Region: DadA; COG0665 481805007530 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase; Provisional; Region: PRK09847 481805007531 Escherichia coli NADP+-dependent gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase PuuC-like; Region: ALDH_GABALDH-PuuC; cd07112 481805007532 NAD(P) binding site [chemical binding]; other site 481805007533 catalytic residues [active] 481805007534 DNA-binding transcriptional repressor PuuR; Provisional; Region: PRK09943 481805007535 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805007536 non-specific DNA binding site [nucleotide binding]; other site 481805007537 salt bridge; other site 481805007538 sequence-specific DNA binding site [nucleotide binding]; other site 481805007539 Cupin domain; Region: Cupin_2; pfam07883 481805007540 gamma-glutamyl-gamma-aminobutyrate hydrolase; Provisional; Region: puuD; PRK11366 481805007541 Subgroup of proteins having the Type 1 glutamine amidotransferase (GATase1) domain; Region: GATase1_2; cd01745 481805007542 catalytic triad [active] 481805007543 Glutamine synthetase [Amino acid transport and metabolism]; Region: GlnA; COG0174 481805007544 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 481805007545 Amino acid transporters [Amino acid transport and metabolism]; Region: PotE; COG0531 481805007546 Protein of unknown function (DUF2543); Region: DUF2543; pfam10820 481805007547 ABC-type oligopeptide transport system, periplasmic component [Amino acid transport and metabolism]; Region: OppA; COG4166 481805007548 The substrate-binding component of an ABC-type dipeptide import system contains the type 2 periplasmic binding fold; Region: PBP2_DppA_like; cd08493 481805007549 peptide binding site [polypeptide binding]; other site 481805007550 antimicrobial peptide ABC transporter permease SapB; Provisional; Region: PRK15110 481805007551 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805007552 dimer interface [polypeptide binding]; other site 481805007553 conserved gate region; other site 481805007554 putative PBP binding loops; other site 481805007555 ABC-ATPase subunit interface; other site 481805007556 antimicrobial peptide ABC transporter permease SapC; Provisional; Region: PRK15111 481805007557 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 481805007558 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805007559 dimer interface [polypeptide binding]; other site 481805007560 conserved gate region; other site 481805007561 putative PBP binding loops; other site 481805007562 ABC-ATPase subunit interface; other site 481805007563 antimicrobial peptide ABC transporter ATP-binding protein; Provisional; Region: PRK15093 481805007564 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805007565 Walker A/P-loop; other site 481805007566 ATP binding site [chemical binding]; other site 481805007567 Q-loop/lid; other site 481805007568 ABC transporter signature motif; other site 481805007569 Walker B; other site 481805007570 D-loop; other site 481805007571 H-loop/switch region; other site 481805007572 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 481805007573 antimicrobial peptide ABC system ATP-binding protein SapF; Provisional; Region: PRK15112 481805007574 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805007575 Walker A/P-loop; other site 481805007576 ATP binding site [chemical binding]; other site 481805007577 Q-loop/lid; other site 481805007578 ABC transporter signature motif; other site 481805007579 Walker B; other site 481805007580 D-loop; other site 481805007581 H-loop/switch region; other site 481805007582 Domain of unknown function, appears to be related to a diverse group of endonucleases; Region: Endonuclease_DUF559; cd01038 481805007583 putative active site [active] 481805007584 enoyl-(acyl carrier protein) reductase; Provisional; Region: PRK07984 481805007585 Enoyl acyl carrier protein (ACP) reductase (ENR), divergent SDR; Region: ENR_SDR; cd05372 481805007586 NAD binding site [chemical binding]; other site 481805007587 homotetramer interface [polypeptide binding]; other site 481805007588 homodimer interface [polypeptide binding]; other site 481805007589 substrate binding site [chemical binding]; other site 481805007590 active site 481805007591 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4950 481805007592 Uncharacterized conserved protein [Function unknown]; Region: COG2128 481805007593 exoribonuclease II; Provisional; Region: PRK05054 481805007594 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 481805007595 RNB domain; Region: RNB; pfam00773 481805007596 S1 RNA binding domain; Region: S1; pfam00575 481805007597 RNase II stability modulator; Provisional; Region: PRK10060 481805007598 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481805007599 putative active site [active] 481805007600 heme pocket [chemical binding]; other site 481805007601 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805007602 metal binding site [ion binding]; metal-binding site 481805007603 active site 481805007604 I-site; other site 481805007605 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805007606 hypothetical protein; Provisional; Region: PRK13658 481805007607 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 481805007608 helix_turn_helix, Deoxyribose operon repressor; Region: HTH_DEOR; smart00420 481805007609 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481805007610 lipoprotein; Provisional; Region: PRK10540 481805007611 translation initiation factor Sui1; Validated; Region: PRK06824 481805007612 Homologs of eIF1/SUI1 including Escherichia coli YciH; Region: YciH_like; cd11567 481805007613 putative rRNA binding site [nucleotide binding]; other site 481805007614 Orotidine 5'-phosphate decarboxylase (ODCase) is a dimeric enzyme that decarboxylates orotidine 5'-monophosphate (OMP) to form uridine 5'-phosphate (UMP), an essential step in the pyrimidine biosynthetic pathway. In mammals, UMP synthase...; Region: OMP_decarboxylase_like; cd04725 481805007615 active site 481805007616 dimer interface [polypeptide binding]; other site 481805007617 Predicted N-acetylglucosaminyl transferase [Carbohydrate transport and metabolism]; Region: COG2956 481805007618 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cl02429 481805007619 TPR motif; other site 481805007620 binding surface 481805007621 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481805007622 binding surface 481805007623 TPR motif; other site 481805007624 Predicted membrane protein [Function unknown]; Region: COG3771 481805007625 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 481805007626 PAP2_like proteins, a super-family of histidine phosphatases and vanadium haloperoxidases, includes type 2 phosphatidic acid phosphatase or lipid phosphate phosphatase (LPP), Glucose-6-phosphatase, Phosphatidylglycerophosphatase B and bacterial acid...; Region: PAP2_like; cd01610 481805007627 active site 481805007628 GTP cyclohydrolase II (RibA). GTP cyclohydrolase II catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5' phosphate, formate, pyrophosphate (APy), and GMP in the biosynthetic pathway of riboflavin. Riboflavin is the...; Region: GTP_cyclohydro2; cd00641 481805007629 dimerization interface [polypeptide binding]; other site 481805007630 active site 481805007631 aconitate hydratase; Validated; Region: PRK09277 481805007632 Aconitase A catalytic domain; Region: AcnA_IRP; cd01586 481805007633 substrate binding site [chemical binding]; other site 481805007634 ligand binding site [chemical binding]; other site 481805007635 Aconitase A swivel domain. This is the major form of the TCA cycle enzyme aconitate hydratase, also known as aconitase and citrate hydro-lyase. It includes bacterial and archaeal aconitase A, and the eukaryotic cytosolic form of aconitase. This group...; Region: AcnA_IRP_Swivel; cd01580 481805007636 substrate binding site [chemical binding]; other site 481805007637 transcriptional regulator CysB; Reviewed; Region: cysB; PRK12681 481805007638 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805007639 The C-terminal substrate domain of LysR-type transcriptional regulator CysB contains type 2 periplasmic binding fold; Region: PBP2_CysB; cd08443 481805007640 substrate binding site [chemical binding]; other site 481805007641 putative dimerization interface [polypeptide binding]; other site 481805007642 DNA topoisomerase I subunit omega; Validated; Region: PRK07561 481805007643 TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomerases (Topo IA) similar to Escherichia coli DNA topoisomerase I. Type IA DNA topoisomerases remove (relax) negative supercoils in the...; Region: TOPRIM_TopoIA_TopoI; cd03363 481805007644 active site 481805007645 interdomain interaction site; other site 481805007646 putative metal-binding site [ion binding]; other site 481805007647 nucleotide binding site [chemical binding]; other site 481805007648 DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, and eukaryotic DNA topoisomerase III and eubacterial and archael reverse gyrases. Topoisomerases clevage single or double stranded DNA...; Region: TOP1Ac; cd00186 481805007649 domain I; other site 481805007650 DNA binding groove [nucleotide binding] 481805007651 phosphate binding site [ion binding]; other site 481805007652 domain II; other site 481805007653 domain III; other site 481805007654 nucleotide binding site [chemical binding]; other site 481805007655 catalytic site [active] 481805007656 domain IV; other site 481805007657 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 481805007658 Topoisomerase DNA binding C4 zinc finger; Region: zf-C4_Topoisom; pfam01396 481805007659 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 481805007660 Topoisomerase I zinc-ribbon-like; Region: Topo_Zn_Ribbon; pfam08272 481805007661 hypothetical protein; Provisional; Region: PRK11037 481805007662 Peptidase family S49 N-terminal; Region: Peptidase_S49_N; pfam08496 481805007663 putative inner membrane peptidase; Provisional; Region: PRK11778 481805007664 Signal peptide peptidase A (SppA), a serine protease, has catalytic Ser-Lys dyad; Region: S49_Sppa_N_C; cd07023 481805007665 tandem repeat interface [polypeptide binding]; other site 481805007666 oligomer interface [polypeptide binding]; other site 481805007667 active site residues [active] 481805007668 putative oxoacyl-(acyl carrier protein) reductase; Provisional; Region: PRK08945 481805007669 Escherichia coli K-12 YCIK-like, classical (c) SDRs; Region: Ycik_SDR_c; cd05340 481805007670 NADP binding site [chemical binding]; other site 481805007671 homodimer interface [polypeptide binding]; other site 481805007672 active site 481805007673 ATP:corrinoid adenosyltransferase [Coenzyme metabolism]; Region: BtuR; COG2109 481805007674 Cob(I)alamin adenosyltransferase N terminal; Region: Co_AT_N; pfam12557 481805007675 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP. This family consists of the BtuR, CobO, CobP proteins all of which are Cob(I)alamin (vitamin B12) adenosyltransferase, which is involved in cobalamin (vitamin B12) biosynthesis. This enzyme is a homodimer; Region: CobA_CobO_BtuR; cd00561 481805007676 homodimer interface [polypeptide binding]; other site 481805007677 Walker A motif; other site 481805007678 ATP binding site [chemical binding]; other site 481805007679 hydroxycobalamin binding site [chemical binding]; other site 481805007680 Walker B motif; other site 481805007681 23S rRNA pseudouridylate synthase B; Provisional; Region: PRK10700 481805007682 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481805007683 RNA binding surface [nucleotide binding]; other site 481805007684 Pseudouridine synthase, Escherichia coli RluB like; Region: PseudoU_synth_RluB; cd02556 481805007685 probable active site [active] 481805007686 Predicted membrane protein (DUF2207); Region: DUF2207; pfam09972 481805007687 hypothetical protein; Provisional; Region: PRK11630 481805007688 Predicted metal-dependent phosphoesterases (PHP family) [General function prediction only]; Region: COG0613 481805007689 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 481805007690 active site 481805007691 Polymerase and Histidinol Phosphatase domain of Histidinol phosphate phosphatase (HisPPase) AMP bound; Region: PHP_HisPPase_AMP; cd07438 481805007692 anthranilate synthase component I; Provisional; Region: PRK13564 481805007693 Anthranilate synthase component I, N terminal region; Region: Anth_synt_I_N; pfam04715 481805007694 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 481805007695 bifunctional glutamine amidotransferase/anthranilate phosphoribosyltransferase; Provisional; Region: PRK09522 481805007696 Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase; Region: GATase1_Anthranilate_Synthase; cd01743 481805007697 glutamine binding [chemical binding]; other site 481805007698 catalytic triad [active] 481805007699 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 481805007700 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 481805007701 bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional; Region: PRK09427 481805007702 Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closure reaction of 1-(o-carboxyphenylamino)-1-deoxyribulose-5-phosphate (CdRP) to indole-3-glycerol phosphate (IGP), accompanied by the...; Region: IGPS; cd00331 481805007703 active site 481805007704 ribulose/triose binding site [chemical binding]; other site 481805007705 phosphate binding site [ion binding]; other site 481805007706 substrate (anthranilate) binding pocket [chemical binding]; other site 481805007707 product (indole) binding pocket [chemical binding]; other site 481805007708 Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of N-(5'- phosphoribosyl)-anthranilate (PRA) to 1-(o-carboxyphenylamino)- 1-deoxyribulose 5-phosphate (CdRP). Most PRAIs are...; Region: PRAI; cd00405 481805007709 active site 481805007710 tryptophan synthase, beta subunit; Region: trpB; TIGR00263 481805007711 Tryptophan synthase-beta: Trptophan synthase is a bifunctional enzyme that catalyses the last two steps in the biosynthesis of L-tryptophan via its alpha and beta reactions. In the alpha reaction, indole 3-glycerol phosphate is cleaved reversibly to...; Region: Trp-synth_B; cd06446 481805007712 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805007713 catalytic residue [active] 481805007714 tryptophan synthase alpha subunit; Provisional; Region: trpA; CHL00200 481805007715 Ttryptophan synthase (TRPS) alpha subunit (TSA). TPRS is a bifunctional tetrameric enzyme (2 alpha and 2 beta subunits) that catalyzes the last two steps of L-tryptophan biosynthesis. Alpha and beta subunit catalyze two distinct reactions which are both...; Region: Tryptophan_synthase_alpha; cd04724 481805007716 substrate binding site [chemical binding]; other site 481805007717 active site 481805007718 catalytic residues [active] 481805007719 heterodimer interface [polypeptide binding]; other site 481805007720 General stress protein [General function prediction only]; Region: GsiB; COG3729 481805007721 YciF bacterial stress response protein, ferritin-like iron-binding domain; Region: YciF; cd07909 481805007722 dimerization interface [polypeptide binding]; other site 481805007723 metal binding site [ion binding]; metal-binding site 481805007724 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3685 481805007725 outer membrane protein W; Provisional; Region: PRK10959 481805007726 hypothetical protein; Provisional; Region: PRK02868 481805007727 intracellular septation protein A; Reviewed; Region: PRK00259 481805007728 Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis; Region: BFIT_BACH; cd03442 481805007729 transport protein TonB; Provisional; Region: PRK10819 481805007730 Gram-negative bacterial tonB protein; Region: TonB; pfam03544 481805007731 YciI-like protein; Reviewed; Region: PRK11370 481805007732 voltage-gated potassium channel; Provisional; Region: PRK10537 481805007733 Ion channel; Region: Ion_trans_2; pfam07885 481805007734 TrkA-N domain; Region: TrkA_N; pfam02254 481805007735 cardiolipin synthetase; Reviewed; Region: cls; PRK01642 481805007736 Phospholipase_D-nuclease N-terminal; Region: PLDc_N; pfam13396 481805007737 Catalytic domain, repeat 1, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_1; cd09152 481805007738 putative active site [active] 481805007739 catalytic site [active] 481805007740 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase and similar proteins; Region: PLDc_EcCLS_like_2; cd09158 481805007741 putative active site [active] 481805007742 catalytic site [active] 481805007743 dsDNA-mimic protein; Reviewed; Region: PRK05094 481805007744 oligopeptide ABC transporter ATP-binding protein OppF; Provisional; Region: PRK15079 481805007745 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805007746 Walker A/P-loop; other site 481805007747 ATP binding site [chemical binding]; other site 481805007748 Q-loop/lid; other site 481805007749 ABC transporter signature motif; other site 481805007750 Walker B; other site 481805007751 D-loop; other site 481805007752 H-loop/switch region; other site 481805007753 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481805007754 oligopeptide transporter ATP-binding component; Provisional; Region: oppD; PRK09473 481805007755 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805007756 Walker A/P-loop; other site 481805007757 ATP binding site [chemical binding]; other site 481805007758 Q-loop/lid; other site 481805007759 ABC transporter signature motif; other site 481805007760 Walker B; other site 481805007761 D-loop; other site 481805007762 H-loop/switch region; other site 481805007763 oligopeptide/dipeptide ABC transporter, ATP-binding protein, C-terminal domain; Region: oligo_HPY; TIGR01727 481805007764 oligopeptide ABC transporter permease OppC; Provisional; Region: PRK15406 481805007765 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 481805007766 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805007767 dimer interface [polypeptide binding]; other site 481805007768 conserved gate region; other site 481805007769 putative PBP binding loops; other site 481805007770 ABC-ATPase subunit interface; other site 481805007771 oligopeptide transporter permease; Reviewed; Region: oppB; PRK09471 481805007772 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805007773 dimer interface [polypeptide binding]; other site 481805007774 conserved gate region; other site 481805007775 putative PBP binding loops; other site 481805007776 ABC-ATPase subunit interface; other site 481805007777 oligopeptide ABC transporter substrate-binding protein OppA; Provisional; Region: PRK15104 481805007778 The substrate-binding component of an ABC-type oligopetide import system contains the type 2 periplasmic binding fold; Region: PBP2_OppA; cd08504 481805007779 peptide binding site [polypeptide binding]; other site 481805007780 hypothetical protein; Provisional; Region: PRK11111 481805007781 bifunctional acetaldehyde-CoA/alcohol dehydrogenase; Provisional; Region: PRK13805 481805007782 Coenzyme A acylating aldehyde dehydrogenase (ACDH), ALDH family 20-like; Region: ALDH_F20_ACDH; cd07122 481805007783 putative catalytic cysteine [active] 481805007784 C-terminal alcohol dehydrogenase domain of the acetaldehyde dehydrogenase-alcohol dehydrogenase bifunctional two-domain protein (AAD); Region: AAD_C; cd08178 481805007785 putative active site [active] 481805007786 metal binding site [ion binding]; metal-binding site 481805007787 thymidine kinase; Provisional; Region: PRK04296 481805007788 global DNA-binding transcriptional dual regulator H-NS; Provisional; Region: PRK10947 481805007789 Domain in histone-like proteins of HNS family; Region: HNS; smart00528 481805007790 Prokaryotic UGPase catalyses the synthesis of UDP-glucose; Region: UGPase_prokaryotic; cd02541 481805007791 dTDP-glucose pyrophosphorylase [Cell envelope biogenesis, outer membrane]; Region: RfbA; COG1209 481805007792 active site 481805007793 tetramer interface; other site 481805007794 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805007795 active site 481805007796 response regulator of RpoS; Provisional; Region: PRK10693 481805007797 phosphorylation site [posttranslational modification] 481805007798 intermolecular recognition site; other site 481805007799 dimerization interface [polypeptide binding]; other site 481805007800 hypothetical protein; Provisional; Region: PRK10279 481805007801 Bacterial patatin-like phospholipase domain containing protein 6; Region: Pat_NTE_like_bacteria; cd07228 481805007802 active site 481805007803 nucleophile elbow; other site 481805007804 SEC-C motif; Region: SEC-C; pfam02810 481805007805 hypothetical protein; Provisional; Region: PRK04233 481805007806 formyltetrahydrofolate deformylase; Reviewed; Region: purU; PRK06027 481805007807 N-terminal ACT domain of formyltetrahydrofolate deformylase (F4HF-DF; formyltetrahydrofolate hydrolase); Region: ACT_F4HF-DF; cd04875 481805007808 Formyltetrahydrofolate deformylase (Formyl-FH4 hydrolase), C-terminal hydrolase domain; Region: FMT_core_Formyl-FH4-Hydrolase_C; cd08648 481805007809 putative active site [active] 481805007810 putative substrate binding site [chemical binding]; other site 481805007811 putative cosubstrate binding site; other site 481805007812 catalytic site [active] 481805007813 respiratory nitrate reductase, gamma subunit; Region: narI; TIGR00351 481805007814 Nitrate reductase delta subunit; Region: Nitrate_red_del; cl00958 481805007815 Nitrate reductase beta subunit [Energy production and conversion]; Region: NarY; COG1140 481805007816 4Fe-4S binding domain; Region: Fer4; cl02805 481805007817 respiratory nitrate reductase, alpha subunit; Region: narG; TIGR01580 481805007818 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_Nitrate-R-NarG-like; cd02750 481805007819 [4Fe-4S] binding site [ion binding]; other site 481805007820 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 481805007821 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 481805007822 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 481805007823 Respiratory nitrate reductase A (NarGHI), alpha chain (NarG) and related proteins. Under anaerobic conditions in the presence of nitrate, E. coli synthesizes the cytoplasmic membrane-bound quinol-nitrate oxidoreductase (NarGHI), which reduces nitrate to...; Region: MopB_CT_Nitrate-R-NarG-like; cd02776 481805007824 molybdopterin cofactor binding site; other site 481805007825 nitrate/nitrite transport protein NarU; Provisional; Region: PRK15034 481805007826 nitrate/nitrite sensor protein NarX; Provisional; Region: PRK10600 481805007827 Type IV pili methyl-accepting chemotaxis transducer N-term; Region: PilJ; pfam13675 481805007828 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805007829 dimerization interface [polypeptide binding]; other site 481805007830 Histidine kinase; Region: HisKA_3; pfam07730 481805007831 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805007832 ATP binding site [chemical binding]; other site 481805007833 Mg2+ binding site [ion binding]; other site 481805007834 G-X-G motif; other site 481805007835 transcriptional regulator NarL; Provisional; Region: PRK10651 481805007836 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805007837 active site 481805007838 phosphorylation site [posttranslational modification] 481805007839 intermolecular recognition site; other site 481805007840 dimerization interface [polypeptide binding]; other site 481805007841 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805007842 DNA binding residues [nucleotide binding] 481805007843 dimerization interface [polypeptide binding]; other site 481805007844 putative invasin; Provisional; Region: PRK10177 481805007845 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 481805007846 Uncharacterized conserved protein involved in intracellular sulfur reduction [Inorganic ion transport and metabolism]; Region: DsrE; COG1553 481805007847 Uncharacterized protein involved in cation transport [Inorganic ion transport and metabolism]; Region: ChaC; COG3703 481805007848 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 481805007849 putative active site pocket [active] 481805007850 dimerization interface [polypeptide binding]; other site 481805007851 putative catalytic residue [active] 481805007852 cation transport regulator; Reviewed; Region: chaB; PRK09582 481805007853 calcium/sodium:proton antiporter; Provisional; Region: PRK10599 481805007854 Sodium/calcium exchanger protein; Region: Na_Ca_ex; pfam01699 481805007855 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 481805007856 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 481805007857 Toxin Ldr, type I toxin-antitoxin system; Region: Ldr_toxin; pfam13940 481805007858 2-dehydro-3-deoxyphosphooctonate aldolase; Provisional; Region: PRK05198 481805007859 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 481805007860 hypothetical protein; Provisional; Region: PRK10941 481805007861 Transglutaminase-like superfamily; Region: Transglut_core2; pfam13369 481805007862 hypothetical protein; Provisional; Region: PRK10278 481805007863 N5-glutamine S-adenosyl-L-methionine-dependent methyltransferase; Provisional; Region: PRK09328 481805007864 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805007865 peptide chain release factor 1; Validated; Region: prfA; PRK00591 481805007866 This domain is found in peptide chain release factors; Region: PCRF; smart00937 481805007867 RF-1 domain; Region: RF-1; pfam00472 481805007868 glutamyl-tRNA reductase; Reviewed; Region: hemA; PRK00045 481805007869 NADP-binding domain of glutamyl-tRNA reductase; Region: NAD_bind_Glutamyl_tRNA_reduct; cd05213 481805007870 tRNA; other site 481805007871 putative tRNA binding site [nucleotide binding]; other site 481805007872 putative NADP binding site [chemical binding]; other site 481805007873 Glutamyl-tRNAGlu reductase, dimerisation domain; Region: GlutR_dimer; pfam00745 481805007874 outer membrane lipoprotein LolB; Region: lolB; TIGR00548 481805007875 Outer membrane lipoprotein LolB; Region: LolB; pfam03550 481805007876 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase; Provisional; Region: ipk; PRK00343 481805007877 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 481805007878 GHMP kinases C terminal; Region: GHMP_kinases_C; pfam08544 481805007879 ribose-phosphate pyrophosphokinase; Provisional; Region: PRK01259 481805007880 N-terminal domain of ribose phosphate pyrophosphokinase; Region: Pribosyltran_N; pfam13793 481805007881 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481805007882 active site 481805007883 putative transporter; Provisional; Region: PRK11660 481805007884 Sulfate transporter N-terminal domain with GLY motif; Region: Sulfate_tra_GLY; pfam13792 481805007885 Sulfate transporter family; Region: Sulfate_transp; pfam00916 481805007886 Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function; Region: STAS_SulP_like_sulfate_transporter; cd07042 481805007887 hypothetical protein; Provisional; Region: PRK10692 481805007888 Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through...; Region: PTH; cd00462 481805007889 putative active site [active] 481805007890 catalytic residue [active] 481805007891 GTP-binding protein YchF; Reviewed; Region: PRK09601 481805007892 YchF GTPase; Region: YchF; cd01900 481805007893 G1 box; other site 481805007894 GTP/Mg2+ binding site [chemical binding]; other site 481805007895 Switch I region; other site 481805007896 G2 box; other site 481805007897 Switch II region; other site 481805007898 G3 box; other site 481805007899 G4 box; other site 481805007900 G5 box; other site 481805007901 TGS_YchF_C: This subfamily represents TGS domain-containing YchF GTP-binding protein, a universally conserved GTPase whose function is unknown. The N-terminal domain of the YchF protein belongs to the Obg-like family of GTPases, and some members of the...; Region: TGS_YchF_C; cd04867 481805007902 Pertactin-like passenger domains (virulence factors), C-terminal, subgroup 1, of autotransporter proteins of the type V secretion system of Gram-negative bacteria. This subgroup includes the passenger domains of Neisseria and Haemophilus IgA1 proteases; Region: PL1_Passenger_AT; cd01343 481805007903 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 481805007904 Autotransporter beta-domain; Region: Autotransporter; pfam03797 481805007905 DNA-binding transcriptional regulator DhaR; Provisional; Region: PRK11388 481805007906 PAS domain; Region: PAS; smart00091 481805007907 putative active site [active] 481805007908 heme pocket [chemical binding]; other site 481805007909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805007910 Walker A motif; other site 481805007911 ATP binding site [chemical binding]; other site 481805007912 Walker B motif; other site 481805007913 arginine finger; other site 481805007914 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 481805007915 dihydroxyacetone kinase subunit DhaK; Provisional; Region: PRK11468 481805007916 Dak1 domain; Region: Dak1; pfam02733 481805007917 dihydroxyacetone kinase subunit DhaL; Provisional; Region: PRK10005 481805007918 dihydroxyacetone kinase subunit M; Provisional; Region: PRK11377 481805007919 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3412 481805007920 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 481805007921 dimerization domain swap beta strand [polypeptide binding]; other site 481805007922 regulatory protein interface [polypeptide binding]; other site 481805007923 active site 481805007924 regulatory phosphorylation site [posttranslational modification]; other site 481805007925 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 481805007926 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 481805007927 trehalase; Provisional; Region: treA; PRK13271 481805007928 Neutral trehalase [Carbohydrate transport and metabolism]; Region: TreA; COG1626 481805007929 hypothetical protein; Provisional; Region: PRK10457 481805007930 c-di-GMP-binding protein [Signal transduction mechanisms]; Region: COG5581 481805007931 Flagellar regulator YcgR; Region: YcgR; pfam07317 481805007932 PilZ domain; Region: PilZ; pfam07238 481805007933 lytic murein endotransglycosylase E; Provisional; Region: emtA; PRK15470 481805007934 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 481805007935 N-acetyl-D-glucosamine binding site [chemical binding]; other site 481805007936 catalytic residue [active] 481805007937 LD-Carboxypeptidase, a serine protease, includes microcin C7 self immunity protein; Region: Peptidase_S66; cd07025 481805007938 dimer interface [polypeptide binding]; other site 481805007939 catalytic triad [active] 481805007940 NhaP-type Na+/H+ and K+/H+ antiporters with a unique C-terminal domain [Inorganic ion transport and metabolism]; Region: COG3263 481805007941 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 481805007942 TrkA-C domain; Region: TrkA_C; pfam02080 481805007943 Transporter associated domain; Region: CorC_HlyC; smart01091 481805007944 alanine racemase; Reviewed; Region: dadX; PRK03646 481805007945 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 481805007946 active site 481805007947 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 481805007948 substrate binding site [chemical binding]; other site 481805007949 catalytic residues [active] 481805007950 dimer interface [polypeptide binding]; other site 481805007951 D-amino acid dehydrogenase small subunit; Validated; Region: PRK00711 481805007952 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805007953 SpoVR family protein; Provisional; Region: PRK11767 481805007954 Uncharacterized conserved protein [Function unknown]; Region: SpoVR; COG2719 481805007955 fatty acid metabolism regulator; Provisional; Region: PRK04984 481805007956 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805007957 DNA-binding site [nucleotide binding]; DNA binding site 481805007958 FadR C-terminal domain; Region: FadR_C; pfam07840 481805007959 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 481805007960 transmembrane helices; other site 481805007961 disulfide bond formation protein B; Provisional; Region: PRK01749 481805007962 DNA polymerase V subunit UmuC; Reviewed; Region: umuC; PRK03609 481805007963 umuC subunit of DNA Polymerase V; Region: PolY_Pol_V_umuC; cd01700 481805007964 active site 481805007965 DNA binding site [nucleotide binding] 481805007966 Domain of unknown function (DUF4113); Region: DUF4113; pfam13438 481805007967 SOS-response transcriptional repressors (RecA-mediated autopeptidases) [Transcription / Signal transduction mechanisms]; Region: LexA; COG1974 481805007968 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 481805007969 Catalytic site [active] 481805007970 hypothetical protein; Provisional; Region: PRK05170 481805007971 2-keto-4-pentenoate hydratase/2-oxohepta-3-ene-1,7-dioic acid hydratase (catechol pathway) [Secondary metabolites biosynthesis, transport, and catabolism]; Region: MhpD; COG0179 481805007972 hypothetical protein; Provisional; Region: PRK10691 481805007973 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3100 481805007974 Bacterial pre-peptidase C-terminal domain; Region: PPC; pfam04151 481805007975 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 481805007976 Fels-1 Prophage Protein-like; Region: Fels1; pfam05666 481805007977 septum formation inhibitor; Reviewed; Region: minC; PRK03511 481805007978 Septum formation inhibitor MinC, N-terminal domain; Region: MinC_N; pfam05209 481805007979 Septum formation inhibitor MinC, C-terminal domain; Region: MinC_C; pfam03775 481805007980 cell division inhibitor MinD; Provisional; Region: PRK10818 481805007981 Bacterial cell division requires the formation of a septum at mid-cell. The site is determined by the min operon products MinC, MinD and MinE. MinC is a nonspecific inhibitor of the septum protein FtsZ. MinE is the supressor of MinC. MinD plays a pivotal...; Region: MinD; cd02036 481805007982 Switch I; other site 481805007983 Switch II; other site 481805007984 cell division topological specificity factor MinE; Reviewed; Region: minE; PRK00296 481805007985 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805007986 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805007987 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805007988 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805007989 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 481805007990 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805007991 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 481805007992 Biofilm development protein YmgB/AriR; Region: YmgB; pfam10798 481805007993 Sensors of blue-light using FAD; Region: BLUF; smart01034 481805007994 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805007995 transcriptional regulator MirA; Provisional; Region: PRK15043 481805007996 Helix-Turn-Helix DNA binding domain of the transcription regulators MlrA and CarA; Region: HTH_MlrA-CarA; cd01104 481805007997 DNA binding residues [nucleotide binding] 481805007998 Protein of unknown function (DUF1398); Region: DUF1398; pfam07166 481805007999 anti-adapter protein IraM; Provisional; Region: PRK09919 481805008000 isocitrate dehydrogenase; Validated; Region: PRK07362 481805008001 isocitrate dehydrogenase; Reviewed; Region: PRK07006 481805008002 23S rRNA pseudouridine synthase E; Provisional; Region: PRK11394 481805008003 Pseudouridine synthase, Escherichia coli RluE; Region: PseudoU_synth_RluE; cd02566 481805008004 probable active site [active] 481805008005 Contains a crystal structure of the Nudix hydrolase from Nitrosomonas europaea, which has an unknown function. In general, members of the Nudix hydrolase superfamily catalyze the hydrolysis of NUcleoside DIphosphates linked to other moieties, X. Enzymes...; Region: Nudix_Hydrolase_2; cd03675 481805008006 nudix motif; other site 481805008007 tRNA methyl transferase. This family represents tRNA(5-methylaminomethyl-2-thiouridine)-methyltransferase which is involved in the biosynthesis of the modified nucleoside 5-methylaminomethyl-2-thiouridine present in the wobble position of some tRNAs; Region: tRNA_Me_trans; cd01998 481805008008 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Region: trmU; TIGR00420 481805008009 putative lysogenization regulator; Reviewed; Region: PRK00218 481805008010 adenylosuccinate lyase; Provisional; Region: PRK09285 481805008011 PurB_like adenylosuccinases (adenylsuccinate lyase, ASL); Region: PurB; cd01598 481805008012 tetramer interface [polypeptide binding]; other site 481805008013 active site 481805008014 DNA-binding transcriptional regulator PhoP; Provisional; Region: PRK10816 481805008015 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805008016 active site 481805008017 phosphorylation site [posttranslational modification] 481805008018 intermolecular recognition site; other site 481805008019 dimerization interface [polypeptide binding]; other site 481805008020 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805008021 DNA binding site [nucleotide binding] 481805008022 sensor protein PhoQ; Provisional; Region: PRK10815 481805008023 PhoQ Sensor; Region: PhoQ_Sensor; pfam08918 481805008024 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cl01054 481805008025 His Kinase A (phospho-acceptor) domain; Region: HisKA; pfam00512 481805008026 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805008027 ATP binding site [chemical binding]; other site 481805008028 Mg2+ binding site [ion binding]; other site 481805008029 G-X-G motif; other site 481805008030 Uncharacterized conserved protein [Function unknown]; Region: COG2850 481805008031 Cupin-like domain; Region: Cupin_8; pfam13621 481805008032 Di- and tripeptidases [Amino acid transport and metabolism]; Region: PepD; COG2195 481805008033 M20 Peptidase T specifically cleaves tripeptides; Region: M20_peptT; cd03892 481805008034 metal binding site [ion binding]; metal-binding site 481805008035 dimer interface [polypeptide binding]; other site 481805008036 putrescine/spermidine ABC transporter ATPase protein; Reviewed; Region: potA; PRK09452 481805008037 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805008038 Walker A/P-loop; other site 481805008039 ATP binding site [chemical binding]; other site 481805008040 Q-loop/lid; other site 481805008041 ABC transporter signature motif; other site 481805008042 Walker B; other site 481805008043 D-loop; other site 481805008044 H-loop/switch region; other site 481805008045 TOBE domain; Region: TOBE_2; pfam08402 481805008046 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 481805008047 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805008048 dimer interface [polypeptide binding]; other site 481805008049 conserved gate region; other site 481805008050 putative PBP binding loops; other site 481805008051 ABC-ATPase subunit interface; other site 481805008052 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 481805008053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805008054 dimer interface [polypeptide binding]; other site 481805008055 conserved gate region; other site 481805008056 putative PBP binding loops; other site 481805008057 ABC-ATPase subunit interface; other site 481805008058 spermidine/putrescine ABC transporter periplasmic substrate-binding protein; Reviewed; Region: potD; PRK09501 481805008059 Bacterial extracellular solute-binding protein; Region: SBP_bac_6; pfam13343 481805008060 NAD-dependent deacetylase; Provisional; Region: PRK00481 481805008061 SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fulgidus Sir2-Af1, and E. coli CobB; and are members of the SIR2 family of proteins, silent information regulator 2 (Sir2) enzymes which...; Region: SIRT5_Af1_CobB; cd01412 481805008062 NAD+ binding site [chemical binding]; other site 481805008063 substrate binding site [chemical binding]; other site 481805008064 Zn binding site [ion binding]; other site 481805008065 fructokinase; Reviewed; Region: PRK09557 481805008066 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481805008067 nucleotide binding site [chemical binding]; other site 481805008068 outer membrane-specific lipoprotein transporter subunit LolE; Provisional; Region: PRK11146 481805008069 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 481805008070 FtsX-like permease family; Region: FtsX; pfam02687 481805008071 lipoprotein transporter ATP-binding subunit; Provisional; Region: lolD; PRK11629 481805008072 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481805008073 Walker A/P-loop; other site 481805008074 ATP binding site [chemical binding]; other site 481805008075 Q-loop/lid; other site 481805008076 ABC transporter signature motif; other site 481805008077 Walker B; other site 481805008078 D-loop; other site 481805008079 H-loop/switch region; other site 481805008080 outer membrane-specific lipoprotein transporter subunit LolC; Provisional; Region: PRK10814 481805008081 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 481805008082 FtsX-like permease family; Region: FtsX; pfam02687 481805008083 Predicted membrane protein [Function unknown]; Region: COG4763 481805008084 Acyltransferase family; Region: Acyl_transf_3; pfam01757 481805008085 transcription-repair coupling factor; Provisional; Region: PRK10689 481805008086 CarD-like/TRCF domain; Region: CarD_TRCF; smart01058 481805008087 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481805008088 ATP binding site [chemical binding]; other site 481805008089 putative Mg++ binding site [ion binding]; other site 481805008090 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805008091 nucleotide binding region [chemical binding]; other site 481805008092 ATP-binding site [chemical binding]; other site 481805008093 This domain is found in proteins necessary for strand-specific repair in DNA such as TRCF in Escherichia coli; Region: TRCF; smart00982 481805008094 L,D-transpeptidase; Provisional; Region: PRK10260 481805008095 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481805008096 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 481805008097 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 481805008098 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481805008099 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481805008100 hypothetical protein; Provisional; Region: PRK11280 481805008101 NADH dehydrogenase, FAD-containing subunit [Energy production and conversion]; Region: Ndh; COG1252 481805008102 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805008103 hypothetical protein; Provisional; Region: PRK04940 481805008104 Beta-glucosidase-related glycosidases [Carbohydrate transport and metabolism]; Region: BglX; COG1472 481805008105 beta-hexosaminidase; Provisional; Region: PRK05337 481805008106 thiamine kinase; Region: ycfN_thiK; TIGR02721 481805008107 Aminoglycoside 3'-phosphotransferase (APH) and Choline Kinase (ChoK) family. The APH/ChoK family is part of a larger superfamily that includes the catalytic domains of other kinases, such as the typical serine/threonine/tyrosine protein kinases (PKs)...; Region: APH_ChoK_like; cd05120 481805008108 active site 481805008109 substrate binding site [chemical binding]; other site 481805008110 ATP binding site [chemical binding]; other site 481805008111 Collagen-binding surface adhesin SpaP (antigen I/II family) [General function prediction only]; Region: FlgN; COG3417 481805008112 Predicted periplasmic lipoprotein [General function prediction only]; Region: COG5633 481805008113 Putative periplasmic lipoprotein; Region: DUF1425; cd09030 481805008114 putative dimer interface [polypeptide binding]; other site 481805008115 Protein Kinase C Interacting protein related (PKCI): PKCI and related proteins belong to the ubiquitous HIT family of hydrolases that act on alpha-phosphates of ribonucleotides. The members of this subgroup have a conserved HxHxHxx motif (x is a...; Region: PKCI_related; cd01276 481805008116 nucleotide binding site/active site [active] 481805008117 HIT family signature motif; other site 481805008118 catalytic residue [active] 481805008119 ferric-rhodotorulic acid outer membrane transporter; Provisional; Region: PRK10003 481805008120 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 481805008121 N-terminal plug; other site 481805008122 ligand-binding site [chemical binding]; other site 481805008123 PTS system glucose-specific transporter subunits IIBC; Provisional; Region: PRK11089 481805008124 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 481805008125 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 481805008126 active site turn [active] 481805008127 phosphorylation site [posttranslational modification] 481805008128 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 481805008129 Predicted metal-dependent hydrolases with the TIM-barrel fold [General function prediction only]; Region: COG1099 481805008130 active site 481805008131 DNA polymerase III subunit delta'; Validated; Region: PRK07993 481805008132 DNA polymerase III, delta subunit, C terminal; Region: DNApol3-delta_C; pfam09115 481805008133 thymidylate kinase; Validated; Region: tmk; PRK00698 481805008134 Thymidine monophosphate kinase (TMPK), also known as thymidylate kinase, catalyzes the phosphorylation of thymidine monophosphate (TMP) to thymidine diphosphate (TDP) utilizing ATP as its preferred phophoryl donor. TMPK represents the rate-limiting step...; Region: TMPK; cd01672 481805008135 TMP-binding site; other site 481805008136 ATP-binding site [chemical binding]; other site 481805008137 conserved hypothetical protein, YceG family; Region: TIGR00247 481805008138 proteins similar to Escherichia coli yceG; Region: yceG_like; cd08010 481805008139 dimerization interface [polypeptide binding]; other site 481805008140 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 481805008141 ADCL_like: 4-Amino-4-deoxychorismate lyase: is a member of the fold-type IV of PLP dependent enzymes that converts 4-amino-4-deoxychorismate (ADC) to p-aminobenzoate and pyruvate. Based on the information available from the crystal structure, most...; Region: ADCL_like; cd01559 481805008142 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805008143 catalytic residue [active] 481805008144 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed; Region: PRK07314 481805008145 Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in fatty acid biosynthesis. KASIII catalyses the initial condensation and KAS I and II catalyze further elongation steps by Claisen...; Region: KAS_I_II; cd00834 481805008146 dimer interface [polypeptide binding]; other site 481805008147 active site 481805008148 acyl carrier protein; Provisional; Region: acpP; PRK00982 481805008149 3-ketoacyl-(acyl-carrier-protein) reductase; Validated; Region: fabG; PRK05557 481805008150 beta-Keto acyl carrier protein reductase (BKR), involved in Type II FAS, classical (c) SDRs; Region: BKR_SDR_c; cd05333 481805008151 NAD(P) binding site [chemical binding]; other site 481805008152 homotetramer interface [polypeptide binding]; other site 481805008153 homodimer interface [polypeptide binding]; other site 481805008154 active site 481805008155 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 481805008156 malonyl CoA-acyl carrier protein transacylase; Region: fabD; TIGR00128 481805008157 3-oxoacyl-(acyl carrier protein) synthase III; Reviewed; Region: PRK09352 481805008158 Ketoacyl-acyl carrier protein synthase III (KASIII) initiates the elongation in type II fatty acid synthase systems. It is found in bacteria and plants. Elongation of fatty acids in the type II systems occurs by Claisen condensation of malonyl-acyl...; Region: KAS_III; cd00830 481805008159 dimer interface [polypeptide binding]; other site 481805008160 active site 481805008161 CoA binding pocket [chemical binding]; other site 481805008162 putative phosphate acyltransferase; Provisional; Region: PRK05331 481805008163 50S ribosomal protein L32; Validated; Region: rpmF; PRK01110 481805008164 hypothetical protein; Provisional; Region: PRK11193 481805008165 Maf-like protein; Region: Maf; pfam02545 481805008166 Nucleotide binding protein Maf. Maf has been implicated in inhibition of septum formation in eukaryotes, bacteria and archaea, but homologs in B.subtilis and S.cerevisiae are nonessential for cell division. Maf has been predicted to be a nucleotide- or...; Region: Maf; cd00555 481805008167 active site 481805008168 dimer interface [polypeptide binding]; other site 481805008169 23S rRNA pseudouridylate synthase C; Provisional; Region: PRK11025 481805008170 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481805008171 RNA binding surface [nucleotide binding]; other site 481805008172 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 481805008173 active site 481805008174 RNase E 5' UTR element as predicted by Rfam (RF00040), score 267.22; Rnase E 5' UTR element 481805008175 ribonuclease, Rne/Rng family; Region: RNaseEG; TIGR00757 481805008176 S1_RNase_E: RNase E and RNase G, S1-like RNA-binding domain. RNase E is an essential endoribonuclease in the processing and degradation of RNA. In addition to its role in mRNA degradation, RNase E has also been implicated in the processing of rRNA, and...; Region: S1_RNase_E; cd04453 481805008177 homodimer interface [polypeptide binding]; other site 481805008178 oligonucleotide binding site [chemical binding]; other site 481805008179 Polyribonucleotide phosphorylase C terminal; Region: PNPase_C; pfam12111 481805008180 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK08027 481805008181 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 481805008182 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK08147 481805008183 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 481805008184 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; cl15855 481805008185 flagellar rod assembly protein/muramidase FlgJ; Validated; Region: flgJ; PRK05684 481805008186 Rod binding protein [Cell envelope biogenesis, outer membrane / Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: COG3951 481805008187 Muramidase (flagellum-specific) [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlgJ; COG1705 481805008188 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 481805008189 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 481805008190 Flagellar basal body L-ring protein [Cell motility and secretion]; Region: FlgH; COG2063 481805008191 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK00249 481805008192 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 481805008193 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 481805008194 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 481805008195 Flagellar basal body rod protein [Cell motility and secretion]; Region: FlgF; COG4787 481805008196 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 481805008197 flagellar basal-body rod protein FlgF; Region: flgF; TIGR02490 481805008198 flagellar hook protein FlgE; Validated; Region: flgE; PRK05682 481805008199 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 481805008200 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 481805008201 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 481805008202 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK06655 481805008203 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 481805008204 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 481805008205 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK05681 481805008206 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 481805008207 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 481805008208 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK05680 481805008209 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 481805008210 Flagellar basal body P-ring biosynthesis protein [Cell motility and secretion / Posttranslational modification, protein turnover, chaperones]; Region: FlgA; COG1261 481805008211 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 481805008212 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 481805008213 anti-sigma28 factor FlgM; Provisional; Region: PRK10810 481805008214 flagella synthesis chaperone protein FlgN; Provisional; Region: PRK15459 481805008215 MurJ/MviN, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_MurJ_like; cd13123 481805008216 MviN-like protein; Region: MVIN; pfam03023 481805008217 Predicted dehydrogenases and related proteins [General function prediction only]; Region: MviM; COG0673 481805008218 Oxidoreductase family, NAD-binding Rossmann fold; Region: GFO_IDH_MocA; pfam01408 481805008219 Oxidoreductase family, C-terminal alpha/beta domain; Region: GFO_IDH_MocA_C; pfam02894 481805008220 hypothetical protein; Provisional; Region: PRK11239 481805008221 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3132 481805008222 ribosomal-protein-S5-alanine N-acetyltransferase; Provisional; Region: PRK10809 481805008223 Acetyltransferases, including N-acetylases of ribosomal proteins [Translation, ribosomal structure and biogenesis]; Region: RimL; COG1670 481805008224 multidrug resistance protein MdtH; Provisional; Region: PRK11646 481805008225 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805008226 putative substrate translocation pore; other site 481805008227 glutaredoxin 2; Provisional; Region: PRK10387 481805008228 GST_N family, Glutaredoxin 2 (GRX2) subfamily; composed of bacterial proteins similar to E. coli GRX2, an atypical GRX with a molecular mass of about 24kD, compared with other GRXs which are 9-12kD in size. GRX2 adopts a GST fold containing an N-terminal...; Region: GST_N_GRX2; cd03037 481805008229 C-terminal domain interface [polypeptide binding]; other site 481805008230 GSH binding site (G-site) [chemical binding]; other site 481805008231 catalytic residues [active] 481805008232 putative dimer interface [polypeptide binding]; other site 481805008233 C-terminal, alpha helical domain of Glutaredoxin 2; Region: GST_C_GRX2; cd03199 481805008234 N-terminal domain interface [polypeptide binding]; other site 481805008235 lipoprotein; Provisional; Region: PRK10598 481805008236 Dihydroorotase (DHOase) catalyzes the reversible interconversion of carbamoyl aspartate to dihydroorotate, a key reaction in the pyrimidine biosynthesis. In contrast to the large polyfunctional CAD proteins of higher organisms, this group of DHOases is...; Region: DHOase; cd01294 481805008237 active site 481805008238 substrate binding pocket [chemical binding]; other site 481805008239 dimer interface [polypeptide binding]; other site 481805008240 DNA damage-inducible protein I; Provisional; Region: PRK10597 481805008241 biofilm formation regulatory protein BssS; Reviewed; Region: bssS; PRK12301 481805008242 N-methyltryptophan oxidase; Provisional; Region: solA; PRK11259 481805008243 hydroxyglutarate oxidase; Provisional; Region: PRK11728 481805008244 Protein of unknown function (DUF2770); Region: DUF2770; pfam10968 481805008245 Cytochrome B561 [Energy production and conversion]; Region: CybB; COG3038 481805008246 hypothetical protein; Provisional; Region: PRK03757 481805008247 putative rhodanese-related sulfurtransferase; Provisional; Region: PRK00142 481805008248 Member of the Rhodanese Homology Domain superfamily. This CD includes Escherichia coli YceA, Bacillus subtilis YbfQ, and similar uncharacterized proteins; Region: RHOD_YceA; cd01518 481805008249 active site residue [active] 481805008250 Bacterial lipid A biosynthesis acyltransferase; Region: Lip_A_acyltrans; pfam03279 481805008251 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LABLAT-like; Region: LPLAT_LABLAT-like; cd07984 481805008252 putative acyl-acceptor binding pocket; other site 481805008253 drug efflux system protein MdtG; Provisional; Region: PRK09874 481805008254 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805008255 putative substrate translocation pore; other site 481805008256 secY/secA suppressor protein; Provisional; Region: PRK11467 481805008257 lipoprotein; Provisional; Region: PRK10175 481805008258 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 481805008259 Glucan_BSP_ModH catalyzes the elongation of beta-1,2 polyglucose chains of glucan; Region: Glucan_BSP_ModH; cd04191 481805008260 Ligand binding site; other site 481805008261 DXD motif; other site 481805008262 glucan biosynthesis protein G; Provisional; Region: mdoG; PRK13274 481805008263 Periplasmic glucan biosynthesis protein, MdoG; Region: MdoG; pfam04349 481805008264 glucans biosynthesis protein; Provisional; Region: opgC; PRK03854 481805008265 Acyltransferase family; Region: Acyl_transf_3; pfam01757 481805008266 Putative catalytic domain, repeat 1, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_1; cd09111 481805008267 PLD-like domain; Region: PLDc_2; pfam13091 481805008268 putative active site [active] 481805008269 catalytic site [active] 481805008270 Putative catalytic domain, repeat 2, of Escherichia coli uncharacterized protein ymdC and similar proteins; Region: PLDc_ymdC_like_2; cd09113 481805008271 PLD-like domain; Region: PLDc_2; pfam13091 481805008272 putative active site [active] 481805008273 catalytic site [active] 481805008274 Macro domain, Appr-1"-pase_like family. The macro domain is a high-affinity ADP-ribose binding module found in a variety of proteins as a stand-alone domain or in combination with other domains like in histone macroH2A and some PARPs (poly...; Region: Macro_Appr_pase_like; cd02908 481805008275 putative ADP-ribose binding site [chemical binding]; other site 481805008276 putative active site [active] 481805008277 Fimbrial protein; Region: Fimbrial; cl01416 481805008278 curli assembly protein CsgC; Provisional; Region: csgC; PRK10102 481805008279 major curlin subunit; Provisional; Region: csgA; PRK10051 481805008280 Curlin associated repeat; Region: Curlin_rpt; pfam07012 481805008281 Curlin associated repeat; Region: Curlin_rpt; pfam07012 481805008282 curlin minor subunit CsgB; Provisional; Region: csgB; PRK10101 481805008283 Curlin associated repeat; Region: Curlin_rpt; pfam07012 481805008284 Curlin associated repeat; Region: Curlin_rpt; pfam07012 481805008285 DNA-binding transcriptional regulator CsgD; Provisional; Region: PRK10100 481805008286 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805008287 DNA binding residues [nucleotide binding] 481805008288 dimerization interface [polypeptide binding]; other site 481805008289 curli assembly protein CsgE; Provisional; Region: PRK10386 481805008290 curli assembly protein CsgF; Provisional; Region: PRK10050 481805008291 curli production assembly/transport protein CsgG; Provisional; Region: PRK15184 481805008292 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 481805008293 Uncharacterized component of anaerobic dehydrogenases [General function prediction only]; Region: TorD; COG3381 481805008294 putative hydrolase; Validated; Region: PRK09248 481805008295 Polymerase and Histidinol Phosphatase domain of Ycdx like; Region: PHP_HisPPase_Ycdx_like; cd07437 481805008296 active site 481805008297 bifunctional glyoxylate/hydroxypyruvate reductase A; Provisional; Region: ghrA; PRK15469 481805008298 Putative glycerate dehydrogenase and related proteins of the D-specific 2-hydroxy dehydrogenase family; Region: GDH_like_2; cd12164 481805008299 putative ligand binding site [chemical binding]; other site 481805008300 NAD binding site [chemical binding]; other site 481805008301 dimerization interface [polypeptide binding]; other site 481805008302 catalytic site [active] 481805008303 (acyl-carrier-protein) S-malonyltransferase [Lipid metabolism]; Region: FabD; COG0331 481805008304 Transposase; Region: HTH_Tnp_1; cl17663 481805008305 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 481805008306 putative transposase OrfB; Reviewed; Region: PHA02517 481805008307 HTH-like domain; Region: HTH_21; pfam13276 481805008308 Integrase core domain; Region: rve; pfam00665 481805008309 Integrase core domain; Region: rve_2; pfam13333 481805008310 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481805008311 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805008312 metal binding site [ion binding]; metal-binding site 481805008313 active site 481805008314 I-site; other site 481805008315 outer membrane protein PgaA; Provisional; Region: pgaA; PRK10049 481805008316 outer membrane N-deacetylase; Provisional; Region: pgaB; PRK14582 481805008317 N-terminal putative catalytic polysaccharide deacetylase domain of bacterial poly-beta-1,6-N-acetyl-D-glucosamine N-deacetylase PgaB, and similar proteins; Region: CE4_PgaB_5s; cd10964 481805008318 putative active site [active] 481805008319 putative metal binding site [ion binding]; other site 481805008320 N-glycosyltransferase; Provisional; Region: PRK11204 481805008321 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 481805008322 DXD motif; other site 481805008323 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 481805008324 putative PGA biosynthesis protein; Provisional; Region: pgaD; PRK14585 481805008325 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 481805008326 hypothetical protein; Provisional; Region: PRK10536 481805008327 Tat-translocated enzyme; Region: tat_substr_1; TIGR01412 481805008328 Predicted iron-dependent peroxidase [Inorganic ion transport and metabolism]; Region: COG2837 481805008329 inactive ferrous ion transporter periplasmic protein EfeO; Provisional; Region: PRK10378 481805008330 Cupredoxin-like domain; Region: Cupredoxin_1; pfam13473 481805008331 Imelysin; Region: Peptidase_M75; pfam09375 481805008332 FTR1 family protein; Region: TIGR00145 481805008333 Na(+)/proline cotransporter PutP and related proteins; solute binding domain; Region: SLC5sbd_PutP; cd11475 481805008334 Na binding site [ion binding]; other site 481805008335 trifunctional transcriptional regulator/proline dehydrogenase/pyrroline-5-carboxylate dehydrogenase; Reviewed; Region: putA; PRK11809 481805008336 Predicted transcriptional regulator [Transcription]; Region: COG3905 481805008337 Proline dehydrogenase [Amino acid transport and metabolism]; Region: PutA; COG0506 481805008338 Delta(1)-pyrroline-5-carboxylate dehydrogenase, PutA; Region: ALDH_PutA-P5CDH; cd07125 481805008339 Glutamate binding site [chemical binding]; other site 481805008340 NAD binding site [chemical binding]; other site 481805008341 catalytic residues [active] 481805008342 HTH-type transcriptional regulator RutR; Provisional; Region: PRK15008 481805008343 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481805008344 YcdC-like protein, C-terminal region; Region: TetR_C_3; pfam08362 481805008345 pyrimidine utilization protein A; Region: RutA; TIGR03612 481805008346 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 481805008347 active site 481805008348 dimer interface [polypeptide binding]; other site 481805008349 non-prolyl cis peptide bond; other site 481805008350 insertion regions; other site 481805008351 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 481805008352 Isochorismatase family; Region: Isochorismatase; pfam00857 481805008353 Cysteine hydrolases; This family contains amidohydrolases, like CSHase (N-carbamoylsarcosine amidohydrolase), involved in creatine metabolism and nicotinamidase, converting nicotinamide to nicotinic acid and ammonia in the pyridine nucleotide cycle. It...; Region: cysteine_hydrolases; cd00431 481805008354 catalytic triad [active] 481805008355 conserved cis-peptide bond; other site 481805008356 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 481805008357 homotrimer interaction site [polypeptide binding]; other site 481805008358 putative active site [active] 481805008359 pyrimidine utilization protein D; Region: RutD; TIGR03611 481805008360 Nitroreductase-like family 5. A subfamily of the nitroreductase family containing uncharacterized proteins that are similar to nitroreductase. Nitroreductase catalyzes the reduction of nitroaromatic compounds such as nitrotoluenes, nitrofurans and...; Region: Nitroreductase_5; cd02148 481805008361 putative FMN binding site [chemical binding]; other site 481805008362 pyrimidine utilization flavin reductase protein F; Region: RutF; TIGR03615 481805008363 pyrimidine utilization transport protein G; Region: RutG; TIGR03616 481805008364 General stress protein [General function prediction only]; Region: GsiB; COG3729 481805008365 NAD(P)H:quinone oxidoreductase; Provisional; Region: PRK03767 481805008366 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481805008367 hypothetical protein; Provisional; Region: PRK10174 481805008368 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 481805008369 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 481805008370 catalytic core [active] 481805008371 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 481805008372 hypothetical protein; Provisional; Region: PRK09784 481805008373 curved DNA-binding protein CbpA; Provisional; Region: PRK10266 481805008374 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 481805008375 HSP70 interaction site [polypeptide binding]; other site 481805008376 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 481805008377 substrate binding site [polypeptide binding]; other site 481805008378 dimer interface [polypeptide binding]; other site 481805008379 chaperone-modulator protein CbpM; Provisional; Region: PRK10265 481805008380 MerR HTH family regulatory protein; Region: MerR_2; pfam13591 481805008381 chaperone protein TorD; Validated; Region: torD; PRK04976 481805008382 trimethylamine N-oxide reductase I catalytic subunit; Provisional; Region: PRK15102 481805008383 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_DMSOR-BSOR-TMAOR; cd02769 481805008384 molybdopterin cofactor binding site [chemical binding]; other site 481805008385 substrate binding site [chemical binding]; other site 481805008386 The MopB_DMSOR-BSOR-TMAOR CD contains dimethylsulfoxide reductase (DMSOR), biotin sulfoxide reductase (BSOR), trimethylamine N-oxide reductase (TMAOR) and other related proteins. DMSOR always catalyzes the reduction of DMSO to dimethylsulfide, but its...; Region: MopB_CT_DMSOR-BSOR-TMAOR; cd02793 481805008387 molybdopterin cofactor binding site; other site 481805008388 trimethylamine N-oxide reductase cytochrome c-type subunit; Provisional; Region: PRK15032 481805008389 cytochrome c-type protein NapC; Provisional; Region: PRK10617; cl17554 481805008390 DNA-binding transcriptional regulator TorR; Provisional; Region: PRK10766 481805008391 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805008392 active site 481805008393 phosphorylation site [posttranslational modification] 481805008394 intermolecular recognition site; other site 481805008395 dimerization interface [polypeptide binding]; other site 481805008396 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805008397 DNA binding site [nucleotide binding] 481805008398 TMAO reductase system periplasmic protein TorT; Provisional; Region: PRK10936 481805008399 TorT-like proteins, a periplasmic binding protein family that activates induction of the Tor respiratory system upon trimethylamine N-oxide (TMAO) electron-acceptor binding in bacteria; Region: PBP1_TorT-like; cd06306 481805008400 putative ligand binding site [chemical binding]; other site 481805008401 hybrid sensory histidine kinase TorS; Provisional; Region: PRK11466 481805008402 HAMP domain; Region: HAMP; pfam00672 481805008403 dimerization interface [polypeptide binding]; other site 481805008404 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805008405 dimer interface [polypeptide binding]; other site 481805008406 phosphorylation site [posttranslational modification] 481805008407 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805008408 ATP binding site [chemical binding]; other site 481805008409 Mg2+ binding site [ion binding]; other site 481805008410 G-X-G motif; other site 481805008411 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805008412 active site 481805008413 phosphorylation site [posttranslational modification] 481805008414 intermolecular recognition site; other site 481805008415 dimerization interface [polypeptide binding]; other site 481805008416 Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphorylating histidine protein kinase serves as a phosphoryl donor to a response regulator protein; the response regulator protein is...; Region: HPT; cd00088 481805008417 putative binding surface; other site 481805008418 active site 481805008419 quinol dehydrogenase membrane component; Provisional; Region: napH; PRK09477 481805008420 4Fe-4S binding domain; Region: Fer4_5; pfam12801 481805008421 4Fe-4S binding domain; Region: Fer4_5; pfam12801 481805008422 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 481805008423 GnsA/GnsB family; Region: GnsAB; pfam08178 481805008424 cold shock gene; Provisional; Region: PRK09891 481805008425 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 481805008426 DNA-binding site [nucleotide binding]; DNA binding site 481805008427 RNA-binding motif; other site 481805008428 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 481805008429 DNA-binding site [nucleotide binding]; DNA binding site 481805008430 RNA-binding motif; other site 481805008431 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 481805008432 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 481805008433 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 481805008434 polysaccharide export protein Wza; Provisional; Region: PRK15078 481805008435 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 481805008436 SLBB domain; Region: SLBB; pfam10531 481805008437 Low molecular weight phosphatase family; Region: LMWPc; cd00115 481805008438 Low molecular weight phosphotyrosine protein phosphatase; Region: LMWPc; pfam01451 481805008439 active site 481805008440 cryptic autophosphorylating protein tyrosine kinase Etk; Provisional; Region: PRK09841 481805008441 Chain length determinant protein; Region: Wzz; pfam02706 481805008442 Chain length determinant protein; Region: Wzz; cl15801 481805008443 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 481805008444 ArsA ATPase functionas as an efflux pump located on the inner membrane of the cell. This ATP-driven oxyanion pump catalyzes the extrusion of arsenite, antimonite and arsenate. Maintenance of a low intracellular concentration of oxyanion produces...; Region: ArsA; cd02035 481805008445 Nucleotide binding site [chemical binding]; other site 481805008446 glucose-1-phosphatase/inositol phosphatase; Provisional; Region: PRK10173 481805008447 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 481805008448 catalytic core [active] 481805008449 Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction; Region: HP_HAP_like; cd07061 481805008450 cytochrome bd-II oxidase subunit 2; Provisional; Region: PRK15028 481805008451 Cytochrome oxidase subunit II; Region: Cyto_ox_2; pfam02322 481805008452 cytochrome bd-II oxidase subunit 1; Provisional; Region: PRK15035 481805008453 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 481805008454 HupH hydrogenase expression protein, C-terminal conserved region; Region: HupH_C; pfam04809 481805008455 HyaE family; HyaE is also called HupG and HoxO. They are proteins serving a critical role in the assembly of multimeric [NiFe] hydrogenases, the enzymes that catalyze the oxidation of molecular hydrogen to enable microorganisms to utilize hydrogen as the...; Region: HyaE; cd02965 481805008456 Endopeptidases belonging to membrane-bound hydrogenases group. These hydrogenases transfer electrons from H2 to a cytochrome that is bound to a membrane-located complex coupling electron transfer to transmembrane proton translocation. Endopeptidase HybD...; Region: H2MP_MemB-H2up; cd06062 481805008457 putative substrate-binding site; other site 481805008458 nickel binding site [ion binding]; other site 481805008459 hydrogenase 1 b-type cytochrome subunit; Provisional; Region: PRK10171 481805008460 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 481805008461 Transposase and inactivated derivatives, IS30 family [DNA replication, recombination, and repair]; Region: Tra8; COG2826 481805008462 Helix-turn-helix domain; Region: HTH_38; pfam13936 481805008463 Integrase core domain; Region: rve; pfam00665 481805008464 hydrogenase (NiFe) small subunit (hydA); Region: hydA; TIGR00391 481805008465 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 481805008466 NADH ubiquinone oxidoreductase, 20 Kd subunit; Region: Oxidored_q6; pfam01058 481805008467 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 481805008468 YccA-like proteins; Region: YccA_like; cd10433 481805008469 Dissimilatory sulfite reductase (desulfoviridin), gamma subunit [Inorganic ion transport and metabolism]; Region: DsrC; COG2920 481805008470 sulfur transfer protein TusE; Provisional; Region: PRK11508 481805008471 Acylphosphatase; Region: Acylphosphatase; cl00551 481805008472 23S rRNA m(5)C1962 methyltransferase; Provisional; Region: PRK15128 481805008473 Putative RNA-binding Domain in PseudoUridine synthase and Archaeosine transglycosylase; Region: PUA; smart00359 481805008474 Middle domain of the SAM-dependent methyltransferase RlmI and related proteins; Region: RlmI_M_like; cd11572 481805008475 putative RNA binding site [nucleotide binding]; other site 481805008476 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805008477 S-adenosylmethionine binding site [chemical binding]; other site 481805008478 heat shock protein HspQ; Provisional; Region: PRK14129 481805008479 Predicted CoA-binding protein [General function prediction only]; Region: COG1832 481805008480 hypothetical protein; Provisional; Region: PRK03641 481805008481 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3110 481805008482 Methylglyoxal synthase catalyzes the enolization of dihydroxyacetone phosphate (DHAP) to produce methylglyoxal. The first part of the catalytic mechanism is believed to be similar to TIM (triosephosphate isomerase) in that both enzymes utilize DHAP to...; Region: MGS; cd01422 481805008483 active site 481805008484 dimer interfaces [polypeptide binding]; other site 481805008485 catalytic residues [active] 481805008486 DNA helicase IV; Provisional; Region: helD; PRK11054 481805008487 DNA helicase IV / RNA helicase N terminal; Region: Nucleolin_N; pfam12462 481805008488 Part of AAA domain; Region: AAA_19; pfam13245 481805008489 Family description; Region: UvrD_C_2; pfam13538 481805008490 Predicted membrane protein [Function unknown]; Region: COG3304 481805008491 Domain of unknown function (DUF307); Region: DUF307; pfam03733 481805008492 Domain of unknown function (DUF307); Region: DUF307; pfam03733 481805008493 TIGR01666 family membrane protein; Region: YCCS 481805008494 FUSC-like inner membrane protein yccS; Region: FUSC-like; pfam12805 481805008495 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 481805008496 Regulator of competence-specific genes [Transcription]; Region: TfoX; COG3070 481805008497 TfoX C-terminal domain; Region: TfoX_C; pfam04994 481805008498 cell division inhibitor SulA; Region: sula; TIGR00623 481805008499 outer membrane protein A; Reviewed; Region: PRK10808 481805008500 OmpA-like transmembrane domain; Region: OmpA_membrane; pfam01389 481805008501 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 481805008502 ligand binding site [chemical binding]; other site 481805008503 Ter macrodomain organizer matS-binding protein; Provisional; Region: PRK05097 481805008504 Predicted ATP-dependent protease [Posttranslational modification, protein turnover, chaperones]; Region: LonB; COG1067 481805008505 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 481805008506 FabA, beta-hydroxydecanoyl-acyl carrier protein (ACP)-dehydratase: Bacterial protein of the type II, fatty acid synthase system that binds ACP and catalyzes both dehydration and isomerization reactions, apparently in the same active site. The FabA...; Region: FabA; cd01287 481805008507 active site 1 [active] 481805008508 dimer interface [polypeptide binding]; other site 481805008509 active site 2 [active] 481805008510 ribosome modulation factor; Provisional; Region: PRK14563 481805008511 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3009 481805008512 Protein of unknown function (DUF330); Region: DUF330; pfam03886 481805008513 paraquat-inducible protein B; Provisional; Region: PRK10807 481805008514 mce related protein; Region: MCE; pfam02470 481805008515 mce related protein; Region: MCE; pfam02470 481805008516 mce related protein; Region: MCE; pfam02470 481805008517 DASH complex subunit Duo1; Region: DASH_Duo1; pfam08651 481805008518 paraquat-inducible membrane protein A; Provisional; Region: PRK15103 481805008519 Paraquat-inducible protein A; Region: PqiA; pfam04403 481805008520 Paraquat-inducible protein A; Region: PqiA; pfam04403 481805008521 ABC transporter ATPase component; Reviewed; Region: PRK11147 481805008522 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805008523 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805008524 Walker A/P-loop; other site 481805008525 Walker A/P-loop; other site 481805008526 ATP binding site [chemical binding]; other site 481805008527 ATP binding site [chemical binding]; other site 481805008528 Q-loop/lid; other site 481805008529 Q-loop/lid; other site 481805008530 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481805008531 ABC transporter signature motif; other site 481805008532 Walker B; other site 481805008533 D-loop; other site 481805008534 ABC transporter; Region: ABC_tran_2; pfam12848 481805008535 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481805008536 23S rRNA m(2)G2445 methyltransferase; Provisional; Region: rlmL; PRK11783 481805008537 THUMP domain associated with S-adenosylmethionine-dependent methyltransferases; Region: THUMP_AdoMetMT; cd11715 481805008538 Putative RNA methylase family UPF0020; Region: UPF0020; pfam01170 481805008539 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805008540 S-adenosylmethionine binding site [chemical binding]; other site 481805008541 Uncharacterized Fe-S protein [General function prediction only]; Region: COG3217 481805008542 MOSC N-terminal beta barrel domain; Region: MOSC_N; pfam03476 481805008543 MOSC domain; Region: MOSC; pfam03473 481805008544 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 481805008545 Ferredoxin [Energy production and conversion]; Region: Fdx; COG0633 481805008546 catalytic loop [active] 481805008547 iron binding site [ion binding]; other site 481805008548 Protein of unknown function (DUF1379); Region: DUF1379; pfam07126 481805008549 dihydroorotate dehydrogenase 2; Reviewed; Region: PRK05286 481805008550 Dihydroorotate dehydrogenase (DHOD) class 2. DHOD catalyzes the oxidation of (S)-dihydroorotate to orotate. This is the fourth step and the only redox reaction in the de novo biosynthesis of UMP, the precursor of all pyrimidine nucleotides. DHOD requires...; Region: DHOD_2_like; cd04738 481805008551 quinone interaction residues [chemical binding]; other site 481805008552 active site 481805008553 catalytic residues [active] 481805008554 FMN binding site [chemical binding]; other site 481805008555 substrate binding site [chemical binding]; other site 481805008556 putativi pili assembly chaperone; Provisional; Region: PRK11385 481805008557 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 481805008558 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 481805008559 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 481805008560 Fimbrial protein; Region: Fimbrial; cl01416 481805008561 Fimbrial protein; Region: Fimbrial; cl01416 481805008562 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 481805008563 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 481805008564 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 481805008565 Fimbrial protein; Region: Fimbrial; cl01416 481805008566 NAD(P)H-dependent FMN reductase; Provisional; Region: PRK10569 481805008567 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481805008568 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805008569 substrate binding pocket [chemical binding]; other site 481805008570 ABC transporter, substrate-binding protein, aliphatic sulfonates family; Region: SsuA_fam; TIGR01728 481805008571 membrane-bound complex binding site; other site 481805008572 hinge residues; other site 481805008573 alkanesulfonate monooxygenase; Provisional; Region: PRK00719 481805008574 Alkanesulfonate monoxygenase is the monoxygenase of a two-component system that catalyzes the conversion of alkanesulfonates to the corresponding aldehyde and sulfite. Alkanesulfonate monoxygenase (SsuD) has an absolute requirement for reduced flavin...; Region: Alkanesulfonate_monoxygenase; cd01094 481805008575 active site 481805008576 dimer interface [polypeptide binding]; other site 481805008577 non-prolyl cis peptide bond; other site 481805008578 insertion regions; other site 481805008579 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 481805008580 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805008581 dimer interface [polypeptide binding]; other site 481805008582 conserved gate region; other site 481805008583 putative PBP binding loops; other site 481805008584 ABC-ATPase subunit interface; other site 481805008585 aliphatic sulfonates transport ATP-binding subunit; Provisional; Region: ssuB; PRK11247 481805008586 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 481805008587 Walker A/P-loop; other site 481805008588 ATP binding site [chemical binding]; other site 481805008589 Q-loop/lid; other site 481805008590 ABC transporter signature motif; other site 481805008591 Walker B; other site 481805008592 D-loop; other site 481805008593 H-loop/switch region; other site 481805008594 aminopeptidase N; Provisional; Region: pepN; PRK14015 481805008595 Peptidase M1 family containing Aminopeptidase N; Region: M1_APN_1; cd09600 481805008596 active site 481805008597 Zn binding site [ion binding]; other site 481805008598 nicotinate phosphoribosyltransferase; Region: NAPRTase; TIGR01514 481805008599 Nicotinate phosphoribosyltransferase (NAPRTase), related to PncB. Nicotinate phosphoribosyltransferase catalyses the formation of NAMN and PPi from 5-phosphoribosy -1-pyrophosphate (PRPP) and nicotinic acid, this is the first, and also rate limiting; Region: PncB_like; cd01401 481805008600 active site 481805008601 asparaginyl-tRNA synthetase; Validated; Region: asnC; PRK03932 481805008602 EcAsnRS_like_N: N-terminal, anticodon recognition domain of the type found in Escherichia coli asparaginyl-tRNA synthetase (AsnRS) and, in Arabidopsis thaliana and Saccharomyces cerevisiae mitochondrial (mt) AsnRS. This domain is a beta-barrel domain (OB...; Region: EcAsnRS_like_N; cd04318 481805008603 putative dimer interface [polypeptide binding]; other site 481805008604 putative anticodon binding site; other site 481805008605 Asx tRNA synthetase (AspRS/AsnRS) class II core domain. Assignment to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure and the presence of three characteristic sequence motifs in the core domain. This family includes AsnRS as well as...; Region: AsxRS_core; cd00776 481805008606 homodimer interface [polypeptide binding]; other site 481805008607 motif 1; other site 481805008608 motif 2; other site 481805008609 active site 481805008610 motif 3; other site 481805008611 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 481805008612 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 481805008613 trimer interface [polypeptide binding]; other site 481805008614 eyelet of channel; other site 481805008615 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 481805008616 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481805008617 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805008618 homodimer interface [polypeptide binding]; other site 481805008619 catalytic residue [active] 481805008620 Zn-dependent hydrolases, including glyoxylases [General function prediction only]; Region: GloB; COG0491 481805008621 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3108 481805008622 Peptidase M15; Region: Peptidase_M15_3; cl01194 481805008623 murein L,D-transpeptidase; Provisional; Region: PRK10594 481805008624 Putative peptidoglycan binding domain; Region: PG_binding_1; pfam01471 481805008625 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 481805008626 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 481805008627 Uncharacterized protein involved in chromosome partitioning [Cell division and chromosome partitioning]; Region: MukB; COG3096 481805008628 MukB N-terminal; Region: MukB; pfam04310 481805008629 Putative exonuclease SbcCD, C subunit; Region: SbcCD_C; pfam13558 481805008630 condesin subunit E; Provisional; Region: PRK05256 481805008631 condesin subunit F; Provisional; Region: PRK05260 481805008632 Methyltransferase domain; Region: Methyltransf_31; pfam13847 481805008633 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805008634 S-adenosylmethionine binding site [chemical binding]; other site 481805008635 Uncharacterized conserved protein [Function unknown]; Region: COG1434 481805008636 YdcF-like. YdcF-like is a large family of mainly bacterial proteins, with a few members found in fungi, plants, and archaea. Escherichia coli YdcF has been shown to bind S-adenosyl-L-methionine (AdoMet), but a biochemical function has not been...; Region: YdcF-like; cd06259 481805008637 putative active site [active] 481805008638 hypothetical protein; Provisional; Region: PRK10593 481805008639 3-deoxy-manno-octulosonate cytidylyltransferase; Provisional; Region: PRK05450 481805008640 CMP-KDO synthetase catalyzes the activation of KDO which is an essential component of the lipopolysaccharide; Region: CMP-KDO-Synthetase; cd02517 481805008641 Ligand binding site; other site 481805008642 oligomer interface; other site 481805008643 hypothetical protein; Provisional; Region: PRK11827 481805008644 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3214 481805008645 Protein of unknown function (DUF1006); Region: DUF1006; pfam06224 481805008646 tetraacyldisaccharide 4'-kinase; Reviewed; Region: lpxK; PRK00652 481805008647 tetraacyldisaccharide 4'-kinase; Region: lpxK; TIGR00682 481805008648 lipid transporter ATP-binding/permease protein; Provisional; Region: PRK11176 481805008649 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481805008650 ATP-binding cassette domain of the bacterial lipid flippase and related proteins, subfamily C; Region: ABCC_MsbA; cd03251 481805008651 Walker A/P-loop; other site 481805008652 ATP binding site [chemical binding]; other site 481805008653 Q-loop/lid; other site 481805008654 ABC transporter signature motif; other site 481805008655 Walker B; other site 481805008656 D-loop; other site 481805008657 H-loop/switch region; other site 481805008658 ComEC family competence protein; Provisional; Region: PRK11539 481805008659 Domain of unknown function (DUF4131); Region: DUF4131; pfam13567 481805008660 ComEC/Rec2-related protein; Region: ComEC_N-term; TIGR00360 481805008661 Metallo-beta-lactamase superfamily; Region: Lactamase_B; pfam00753 481805008662 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 481805008663 IHF dimer interface [polypeptide binding]; other site 481805008664 IHF - DNA interface [nucleotide binding]; other site 481805008665 30S ribosomal protein S1; Reviewed; Region: rpsA; PRK06299 481805008666 S1_RPS1_repeat_ec2_hs2: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture...; Region: S1_RPS1_repeat_ec2_hs2; cd04465 481805008667 RNA binding site [nucleotide binding]; other site 481805008668 S1_RPS1_repeat_ec3: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec3; cd05688 481805008669 RNA binding site [nucleotide binding]; other site 481805008670 S1_RPS1_repeat_ec4: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec4; cd05689 481805008671 RNA binding site [nucleotide binding]; other site 481805008672 S1_RPS1_repeat_ec5: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec5; cd05690 481805008673 RNA binding site [nucleotide binding]; other site 481805008674 S1_RPS1_repeat_ec6: Ribosomal protein S1 (RPS1) domain. RPS1 is a component of the small ribosomal subunit thought to be involved in the recognition and binding of mRNA's during translation initiation. The bacterial RPS1 domain architecture consists...; Region: S1_RPS1_repeat_ec6; cd05691 481805008675 RNA binding site [nucleotide binding]; other site 481805008676 cytidylate kinase; Provisional; Region: cmk; PRK00023 481805008677 Cytidine monophosphate kinase (CMPK) catalyzes the reversible phosphorylation of cytidine monophosphate (CMP) to produce cytidine diphosphate (CDP), using ATP as the preferred phosphoryl donor; Region: CMPK; cd02020 481805008678 CMP-binding site; other site 481805008679 The sites determining sugar specificity; other site 481805008680 Zn-dependent protease with chaperone function [Posttranslational modification, protein turnover, chaperones]; Region: HtpX; COG0501 481805008681 3-phosphoshikimate 1-carboxyvinyltransferase; Provisional; Region: PRK02427 481805008682 Enol pyruvate transferases family includes EPSP synthases and UDP-N-acetylglucosamine enolpyruvyl transferase. Both enzymes catalyze the reaction of enolpyruvyl transfer; Region: EPT-like; cd01554 481805008683 hinge; other site 481805008684 active site 481805008685 Phosphoserine aminotransferase (PSAT) family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major group in this CD corresponds to phosphoserine aminotransferase (PSAT). PSAT is active as...; Region: PSAT_like; cd00611 481805008686 homodimer interface [polypeptide binding]; other site 481805008687 substrate-cofactor binding pocket; other site 481805008688 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805008689 catalytic residue [active] 481805008690 Predicted membrane protein [Function unknown]; Region: COG2323 481805008691 uncharacterized domain; Region: TIGR00702 481805008692 YcaO-like family; Region: YcaO; pfam02624 481805008693 formate transporter; Provisional; Region: PRK10805 481805008694 formate acetyltransferase 1; Region: pyr_form_ly_1; TIGR01255 481805008695 Pyruvate formate lyase 1; Region: PFL1; cd01678 481805008696 coenzyme A binding site [chemical binding]; other site 481805008697 active site 481805008698 catalytic residues [active] 481805008699 glycine loop; other site 481805008700 pyruvate formate lyase-activating enzyme 1; Provisional; Region: pflA; PRK11145 481805008701 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805008702 FeS/SAM binding site; other site 481805008703 hypothetical protein; Provisional; Region: PRK09739 481805008704 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481805008705 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481805008706 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805008707 The C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator CrgA-like, contains the type 2 periplasmic binding fold; Region: PBP2_CrgA_like_5; cd08474 481805008708 putative effector binding pocket; other site 481805008709 putative dimerization interface [polypeptide binding]; other site 481805008710 Amino acid permease; Region: AA_permease_2; pfam13520 481805008711 putative MFS family transporter protein; Provisional; Region: PRK03633 481805008712 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805008713 putative substrate translocation pore; other site 481805008714 Isochorismatase family; Region: Isochorismatase; pfam00857 481805008715 YcaC related amidohydrolases; E.coli YcaC is an homooctameric hydrolase with unknown specificity. Despite its weak sequence similarity, it is structurally related to other amidohydrolases and shares conserved active site residues with them; Region: YcaC_related; cd01012 481805008716 catalytic triad [active] 481805008717 dimer interface [polypeptide binding]; other site 481805008718 conserved cis-peptide bond; other site 481805008719 DMSO reductase anchor subunit (DmsC); Region: DmsC; pfam04976 481805008720 DMSO reductase, iron-sulfur subunit; Region: DMSO_dmsB; TIGR02951 481805008721 4Fe-4S binding domain; Region: Fer4; pfam00037 481805008722 anaerobic dimethyl sulfoxide reductase subunit A; Provisional; Region: PRK14990 481805008723 Tat (twin-arginine translocation) pathway signal sequence; Region: TAT_signal_seq; TIGR01409 481805008724 This CD (MopB_DmsA-EC) includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_DmsA-EC; cd02770 481805008725 putative [Fe4-S4] binding site [ion binding]; other site 481805008726 putative molybdopterin cofactor binding site [chemical binding]; other site 481805008727 The MopB_CT_DmsA-EC CD includes the DmsA enzyme of the dmsABC operon encoding the anaerobic dimethylsulfoxide reductase (DMSOR) of Escherichia coli and other related DMSOR-like enzymes. Unlike other DMSOR-like enzymes, this group has a predicted...; Region: MopB_CT_DmsA-EC; cd02794 481805008728 putative molybdopterin cofactor binding site; other site 481805008729 seryl-tRNA synthetase; Provisional; Region: PRK05431 481805008730 Seryl-tRNA synthetase N-terminal domain; Region: Seryl_tRNA_N; pfam02403 481805008731 Seryl-tRNA synthetase (SerRS) class II core catalytic domain. SerRS is responsible for the attachment of serine to the 3' OH group of ribose of the appropriate tRNA. This domain It is primarily responsible for ATP-dependent formation of the enzyme...; Region: SerRS_core; cd00770 481805008732 dimer interface [polypeptide binding]; other site 481805008733 active site 481805008734 motif 1; other site 481805008735 motif 2; other site 481805008736 motif 3; other site 481805008737 recombination factor protein RarA; Reviewed; Region: PRK13342 481805008738 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805008739 Walker A motif; other site 481805008740 ATP binding site [chemical binding]; other site 481805008741 Walker B motif; other site 481805008742 arginine finger; other site 481805008743 MgsA AAA+ ATPase C terminal; Region: MgsA_C; pfam12002 481805008744 periplasmic chaperone LolA; Region: lolA; TIGR00547 481805008745 lipoprotein chaperone; Reviewed; Region: lolA; PRK00031 481805008746 DNA translocase FtsK; Provisional; Region: PRK10263 481805008747 Domain of unknown function (DUF4117); Region: DUF4117; pfam13491 481805008748 DNA translocase FtsK; Provisional; Region: PRK10263 481805008749 FtsK/SpoIIIE family; Region: FtsK_SpoIIIE; pfam01580 481805008750 Ftsk gamma domain; Region: Ftsk_gamma; pfam09397 481805008751 leucine-responsive transcriptional regulator; Provisional; Region: PRK11169 481805008752 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481805008753 putative DNA binding site [nucleotide binding]; other site 481805008754 putative Zn2+ binding site [ion binding]; other site 481805008755 AsnC family; Region: AsnC_trans_reg; pfam01037 481805008756 thioredoxin reductase; Provisional; Region: PRK10262 481805008757 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481805008758 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805008759 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11174 481805008760 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481805008761 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805008762 Walker A/P-loop; other site 481805008763 ATP binding site [chemical binding]; other site 481805008764 Q-loop/lid; other site 481805008765 ABC transporter signature motif; other site 481805008766 Walker B; other site 481805008767 D-loop; other site 481805008768 H-loop/switch region; other site 481805008769 cysteine/glutathione ABC transporter membrane/ATP-binding component; Reviewed; Region: PRK11160 481805008770 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481805008771 ATP-binding cassette domain of CydCD, subfamily C; Region: ABCC_cytochrome_bd; cd03247 481805008772 Walker A/P-loop; other site 481805008773 ATP binding site [chemical binding]; other site 481805008774 Q-loop/lid; other site 481805008775 ABC transporter signature motif; other site 481805008776 Walker B; other site 481805008777 D-loop; other site 481805008778 H-loop/switch region; other site 481805008779 leucyl/phenylalanyl-tRNA--protein transferase; Reviewed; Region: aat; PRK00301 481805008780 S1_IF1: Translation Initiation Factor IF1, S1-like RNA-binding domain. IF1 contains an S1-like RNA-binding domain, which is found in a wide variety of RNA-associated proteins. Translation initiation includes a number of interrelated steps preceding the...; Region: S1_IF1; cd04451 481805008781 rRNA binding site [nucleotide binding]; other site 481805008782 predicted 30S ribosome binding site; other site 481805008783 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805008784 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805008785 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805008786 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805008787 ATP-dependent Clp protease adaptor protein ClpS; Reviewed; Region: clpS; PRK00033 481805008788 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 481805008789 DNA-binding site [nucleotide binding]; DNA binding site 481805008790 RNA-binding motif; other site 481805008791 macrolide transporter ATP-binding /permease protein; Provisional; Region: PRK10535 481805008792 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481805008793 Walker A/P-loop; other site 481805008794 ATP binding site [chemical binding]; other site 481805008795 Q-loop/lid; other site 481805008796 ABC transporter signature motif; other site 481805008797 Walker B; other site 481805008798 D-loop; other site 481805008799 H-loop/switch region; other site 481805008800 MacB-like periplasmic core domain; Region: MacB_PCD; pfam12704 481805008801 FtsX-like permease family; Region: FtsX; pfam02687 481805008802 macrolide transporter subunit MacA; Provisional; Region: PRK11578 481805008803 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481805008804 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805008805 Protein of unknown function (DUF535); Region: DUF535; pfam04393 481805008806 Predicted ATP-dependent endonuclease of the OLD family [DNA replication, recombination, and repair]; Region: COG3593 481805008807 Protein of unknown function (DUF2813); Region: DUF2813; pfam11398 481805008808 TOPRIM_OLD: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in bacterial and archaeal nucleases of the OLD (overcome lysogenization defect) family. The bacteriophage P2 OLD protein, which has DNase as well as...; Region: TOPRIM_OLD; cd01026 481805008809 putative active site [active] 481805008810 putative metal-binding site [ion binding]; other site 481805008811 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 481805008812 amphipathic channel; other site 481805008813 Asn-Pro-Ala signature motifs; other site 481805008814 Predicted membrane protein [Function unknown]; Region: COG2431 481805008815 hybrid cluster protein; Provisional; Region: PRK05290 481805008816 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 481805008817 ACS interaction site; other site 481805008818 CODH interaction site; other site 481805008819 Hybrid cluster protein (HCP), formerly known as prismane, is thought to play a role in nitrogen metabolism but its specific function is unknown. HCP has three structural domains, an N-terminal alpha-helical domain, and two similar domains comprising a...; Region: HCP; cd01914 481805008820 hybrid metal cluster; other site 481805008821 HCP oxidoreductase, NADH-dependent; Provisional; Region: PRK10684 481805008822 Iron-sulfur binding ferredoxin reductase (FNR) proteins combine the FAD and NAD(P) binding regions of FNR with an iron-sulfur binding cluster domain. Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron...; Region: FNR_iron_sulfur_binding_1; cd06215 481805008823 FAD binding pocket [chemical binding]; other site 481805008824 FAD binding motif [chemical binding]; other site 481805008825 phosphate binding motif [ion binding]; other site 481805008826 beta-alpha-beta structure motif; other site 481805008827 NAD binding pocket [chemical binding]; other site 481805008828 2Fe-2S iron-sulfur cluster binding domain. Iron-sulfur proteins play an important role in electron transfer processes and in various enzymatic reactions. The family includes plant and algal ferredoxins, which act as electron carriers in photosynthesis...; Region: fer2; cd00207 481805008829 catalytic loop [active] 481805008830 iron binding site [ion binding]; other site 481805008831 pyruvate dehydrogenase; Provisional; Region: PRK09124 481805008832 Pyrimidine (PYR) binding domain of POX; Region: TPP_PYR_POX; cd07039 481805008833 PYR/PP interface [polypeptide binding]; other site 481805008834 dimer interface [polypeptide binding]; other site 481805008835 tetramer interface [polypeptide binding]; other site 481805008836 TPP binding site [chemical binding]; other site 481805008837 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 481805008838 Thiamine pyrophosphate (TPP) family, Pyruvate oxidase (POX) subfamily, TPP-binding module; composed of proteins similar to Lactobacillus plantarum POX, which plays a key role in controlling acetate production under aerobic conditions. POX decarboxylates...; Region: TPP_POX; cd02014 481805008839 TPP-binding site [chemical binding]; other site 481805008840 Threonine aldolase [Amino acid transport and metabolism]; Region: GLY1; COG2008 481805008841 Low-specificity threonine aldolase (TA). This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). TA catalyzes the conversion of L-threonine or L-allo-threonine to glycine and acetaldehyde in a...; Region: TA_like; cd06502 481805008842 tetramer interface [polypeptide binding]; other site 481805008843 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805008844 catalytic residue [active] 481805008845 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 481805008846 atypical (a) SDRs, subgroup 2; Region: SDR_a2; cd05245 481805008847 putative NAD(P) binding site [chemical binding]; other site 481805008848 putative active site [active] 481805008849 Protein of unknown function (DUF2867); Region: DUF2867; pfam11066 481805008850 Nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: WcaG; COG0451 481805008851 Rossmann-fold NAD(P)(+)-binding proteins; Region: NADB_Rossmann; cl09931 481805008852 NAD(P) binding site [chemical binding]; other site 481805008853 active site 481805008854 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 481805008855 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 481805008856 amidase catalytic site [active] 481805008857 Zn binding residues [ion binding]; other site 481805008858 substrate binding site [chemical binding]; other site 481805008859 hypothetical protein; Provisional; Region: PRK02877 481805008860 putative lipoprotein; Provisional; Region: PRK10533 481805008861 arginine transporter ATP-binding subunit; Provisional; Region: artP; PRK11124 481805008862 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805008863 Walker A/P-loop; other site 481805008864 ATP binding site [chemical binding]; other site 481805008865 Q-loop/lid; other site 481805008866 ABC transporter signature motif; other site 481805008867 Walker B; other site 481805008868 D-loop; other site 481805008869 H-loop/switch region; other site 481805008870 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 481805008871 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805008872 substrate binding pocket [chemical binding]; other site 481805008873 membrane-bound complex binding site; other site 481805008874 hinge residues; other site 481805008875 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 481805008876 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805008877 dimer interface [polypeptide binding]; other site 481805008878 conserved gate region; other site 481805008879 putative PBP binding loops; other site 481805008880 ABC-ATPase subunit interface; other site 481805008881 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805008882 dimer interface [polypeptide binding]; other site 481805008883 conserved gate region; other site 481805008884 putative PBP binding loops; other site 481805008885 ABC-ATPase subunit interface; other site 481805008886 putative ABC transporter arginine-biding protein; Provisional; Region: PRK15007 481805008887 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805008888 substrate binding pocket [chemical binding]; other site 481805008889 membrane-bound complex binding site; other site 481805008890 hinge residues; other site 481805008891 23S rRNA (uracil-5-)-methyltransferase RumB; Region: meth_trns_rumB; TIGR02085 481805008892 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805008893 S-adenosylmethionine binding site [chemical binding]; other site 481805008894 Protein of unknown function (DUF2593); Region: DUF2593; pfam10767 481805008895 ABC-type spermidine/putrescine transport system, permease component II [Amino acid transport and metabolism]; Region: PotC; COG1177 481805008896 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805008897 dimer interface [polypeptide binding]; other site 481805008898 conserved gate region; other site 481805008899 putative PBP binding loops; other site 481805008900 ABC-ATPase subunit interface; other site 481805008901 ABC-type Fe3+ transport system, permease component [Inorganic ion transport and metabolism]; Region: ThiP; COG1178 481805008902 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805008903 dimer interface [polypeptide binding]; other site 481805008904 conserved gate region; other site 481805008905 putative PBP binding loops; other site 481805008906 ABC-ATPase subunit interface; other site 481805008907 putrescine transporter ATP-binding subunit; Provisional; Region: potG; PRK11607 481805008908 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805008909 Walker A/P-loop; other site 481805008910 ATP binding site [chemical binding]; other site 481805008911 Q-loop/lid; other site 481805008912 ABC transporter signature motif; other site 481805008913 Walker B; other site 481805008914 D-loop; other site 481805008915 H-loop/switch region; other site 481805008916 TOBE domain; Region: TOBE_2; pfam08402 481805008917 putrescine transporter subunit: periplasmic-binding component of ABC superfamily; Provisional; Region: PRK10682 481805008918 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; cl17199 481805008919 Putative bacterial sensory transduction regulator; Region: YbjN; pfam10722 481805008920 ribosomal protein S6 modification protein; Provisional; Region: PRK10446 481805008921 RimK-like ATP-grasp domain; Region: RimK; pfam08443 481805008922 This family contains NADPH-dependent flavin reductase and oxygen-insensitive nitroreductase. These enzymes are homodimeric flavoproteins that contain one FMN per monomer as a cofactor. Flavin reductase catalyzes the reduction of flavin by using NADPH as...; Region: NfsA_FRP; cd02146 481805008923 dimer interface [polypeptide binding]; other site 481805008924 FMN binding site [chemical binding]; other site 481805008925 NADPH bind site [chemical binding]; other site 481805008926 Protein of unknown function (DUF1418); Region: DUF1418; pfam07214 481805008927 Glutaredoxin (GRX) family; composed of GRX, approximately 10 kDa in size, and proteins containing a GRX or GRX-like domain. GRX is a glutathione (GSH) dependent reductase, catalyzing the disulfide reduction of target proteins such as ribonucleotide...; Region: GRX_family; cd02066 481805008928 GSH binding site [chemical binding]; other site 481805008929 catalytic residues [active] 481805008930 Putative inner membrane protein of Enterobacteriaceae; Region: YbjM; pfam11045 481805008931 putative transporter; Provisional; Region: PRK04972 481805008932 Predicted Permease Membrane Region; Region: Asp-Al_Ex; pfam06826 481805008933 TrkA-C domain; Region: TrkA_C; pfam02080 481805008934 TrkA-C domain; Region: TrkA_C; pfam02080 481805008935 AspT/YidE/YbjL antiporter duplication domain; Region: YidE_YbjL_dupl; TIGR01625 481805008936 DNA-binding transcriptional regulator; Provisional; Region: PRK09678 481805008937 Ogr/Delta-like zinc finger; Region: Ogr_Delta; pfam04606 481805008938 tail protein; Provisional; Region: D; PHA02561 481805008939 Phage protein U [General function prediction only]; Region: COG3499 481805008940 phage tail tape measure protein, TP901 family, core region; Region: tape_meas_TP901; TIGR01760 481805008941 Mu-like prophage FluMu protein gp41; Region: FluMu_gp41; pfam10109 481805008942 major tail tube protein; Provisional; Region: FII; PHA02600 481805008943 major tail sheath protein; Provisional; Region: FI; PHA02560 481805008944 Site-specific recombinases, DNA invertase Pin homologs [DNA replication, recombination, and repair]; Region: PinR; COG1961 481805008945 Serine Recombinase (SR) family, Resolvase and Invertase subfamily, catalytic domain; members contain a C-terminal DNA binding domain. Serine recombinases catalyze site-specific recombination of DNA molecules by a concerted, four-strand cleavage and...; Region: SR_ResInv; cd03768 481805008946 catalytic residues [active] 481805008947 catalytic nucleophile [active] 481805008948 Presynaptic Site I dimer interface [polypeptide binding]; other site 481805008949 Synaptic Antiparallel dimer interface [polypeptide binding]; other site 481805008950 Synaptic Flat tetramer interface [polypeptide binding]; other site 481805008951 Synaptic Site I dimer interface [polypeptide binding]; other site 481805008952 Helix-turn-helix domain of Hin and related proteins, a family of DNA-binding domains unique to bacteria and represented by the Hin protein of Salmonella. The basic HTH domain is a simple fold comprised of three core helices that form a right-handed...; Region: HTH_Hin_like; cd00569 481805008953 DNA-binding interface [nucleotide binding]; DNA binding site 481805008954 Phage Tail Collar Domain; Region: Collar; pfam07484 481805008955 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 481805008956 Caudovirales tail fibre assembly protein; Region: Caudo_TAP; pfam02413 481805008957 Phage tail-collar fibre protein; Region: DUF3751; pfam12571 481805008958 Bacteriophage P2-related tail formation protein [General function prediction only]; Region: gpI; COG4385 481805008959 baseplate assembly protein; Provisional; Region: J; PHA02568 481805008960 baseplate wedge subunit; Provisional; Region: W; PHA02516 481805008961 phage baseplate assembly protein V; Region: phage_P2_V; TIGR01644 481805008962 Phage P2 baseplate assembly protein gpV [General function prediction only]; Region: gpV; COG4540 481805008963 Alpha amylase catalytic domain family; Region: AmyAc_family; cl07893 481805008964 Phage virion morphogenesis family; Region: Phage_tail_S; pfam05069 481805008965 P2 phage tail completion protein R (GpR); Region: P2_Phage_GpR; pfam06891 481805008966 phage lysis regulatory protein, LysB family; Region: phage_LysB; TIGR03495 481805008967 Endolysins and autolysins are found in viruses and bacteria, respectively. The ds DNA phages of eubacteria use endolysins or muralytic enzymes in conjunction with hollin, a small membrane protein, to degrade the peptidoglycan found in bacterial cell...; Region: endolysin_autolysin; cd00737 481805008968 catalytic residues [active] 481805008969 P2-like prophage tail protein X [General function prediction only]; Region: COG5004 481805008970 Phage head completion protein (GPL); Region: Phage_GPL; pfam05926 481805008971 terminase endonuclease subunit; Provisional; Region: M; PHA02537 481805008972 Phage small terminase subunit; Region: Phage_term_smal; pfam05944 481805008973 capsid protein; Provisional; Region: N; PHA02538 481805008974 Phage capsid scaffolding protein (GPO) serine peptidase; Region: Phage_GPO; pfam05929 481805008975 terminase ATPase subunit; Provisional; Region: P; PHA02535 481805008976 Putative ATPase subunit of terminase (gpP-like); Region: Terminase_5; pfam06056 481805008977 Mu-like prophage FluMu protein gp28 [General function prediction only]; Region: COG4373 481805008978 portal vertex protein; Provisional; Region: Q; PHA02536 481805008979 Phage portal protein; Region: Phage_portal; pfam04860 481805008980 DinI-like family; Region: DinI; pfam06183 481805008981 Bacteriophage replication gene A protein (GPA); Region: Phage_GPA; pfam05840 481805008982 Herpesvirus large structural phosphoprotein UL32; Region: Herpes_UL32; pfam06070 481805008983 DNA adenine methylase (dam); Region: dam; TIGR00571 481805008984 DksA-like zinc finger domain containing protein; Region: PHA00080 481805008985 Protein of unknown function (DUF2732); Region: DUF2732; pfam10809 481805008986 Protein of unknown function (DUF2724); Region: DUF2724; pfam10893 481805008987 Phage regulatory protein CII (CP76); Region: Phage_CP76; pfam06892 481805008988 Predicted transcriptional regulator [Transcription]; Region: COG2932 481805008989 Bacteriophage CI repressor helix-turn-helix domain; Region: Phage_CI_repr; pfam07022 481805008990 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 481805008991 Catalytic site [active] 481805008992 hypothetical protein; Provisional; Region: PRK10040 481805008993 integrase; Provisional; Region: int; PHA02601 481805008994 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 481805008995 active site 481805008996 DNA binding site [nucleotide binding] 481805008997 Int/Topo IB signature motif; other site 481805008998 transcriptional repressor BetI; Region: betaine_BetI; TIGR03384 481805008999 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481805009000 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 481805009001 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805009002 putative substrate translocation pore; other site 481805009003 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481805009004 Predicted hydrolases of the HAD superfamily [General function prediction only]; Region: Cof; COG0561 481805009005 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805009006 active site 481805009007 motif I; other site 481805009008 motif II; other site 481805009009 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805009010 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 481805009011 multidrug efflux system translocase MdfA; Provisional; Region: PRK15402 481805009012 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805009013 putative substrate translocation pore; other site 481805009014 PAP2_like proteins, BcrC_like subfamily. Several members of this family have been annotated as bacitracin transport permeases, as it was suspected that they form the permease component of an ABC transporter system. It was shown, however, that BcrC from...; Region: PAP2_BcrC_like; cd03385 481805009015 Membrane-associated phospholipid phosphatase [Lipid metabolism]; Region: PgpB; COG0671 481805009016 active site 481805009017 DNA-binding transcriptional repressor DeoR; Provisional; Region: PRK10681 481805009018 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 481805009019 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481805009020 D-alanyl-D-alanine carboxypeptidase fraction C; Provisional; Region: PRK10001 481805009021 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 481805009022 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 481805009023 Glutathione S-transferase [Posttranslational modification, protein turnover, chaperones]; Region: Gst; COG0625 481805009024 GST_N family, unknown subfamily 2; composed of uncharacterized bacterial proteins with similarity to GSTs. GSTs are cytosolic dimeric proteins involved in cellular detoxification by catalyzing the conjugation of glutathione (GSH) with a wide range of...; Region: GST_N_2; cd03047 481805009025 putative C-terminal domain interface [polypeptide binding]; other site 481805009026 putative GSH binding site (G-site) [chemical binding]; other site 481805009027 putative dimer interface [polypeptide binding]; other site 481805009028 C-terminal, alpha helical domain of the Glutathione S-transferase family; Region: GST_C_family; cl02776 481805009029 N-terminal domain interface [polypeptide binding]; other site 481805009030 dimer interface [polypeptide binding]; other site 481805009031 substrate binding pocket (H-site) [chemical binding]; other site 481805009032 dehydrogenase, PQQ-dependent, s-GDH family; Region: non_repeat_PQQ; TIGR03606 481805009033 Glucose / Sorbosone dehydrogenase; Region: GSDH; pfam07995 481805009034 biofilm formation regulatory protein BssR; Reviewed; Region: bssR; PRK12302 481805009035 ribosomal protein S12 methylthiotransferase; Provisional; Region: rimO; PRK14862 481805009036 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 481805009037 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805009038 FeS/SAM binding site; other site 481805009039 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4737 481805009040 Predicted transcriptional regulator [Transcription]; Region: COG2944 481805009041 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805009042 non-specific DNA binding site [nucleotide binding]; other site 481805009043 salt bridge; other site 481805009044 sequence-specific DNA binding site [nucleotide binding]; other site 481805009045 c-di-GMP synthetase (diguanylate cyclase, GGDEF domain) [Signal transduction mechanisms]; Region: COG2199 481805009046 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805009047 metal binding site [ion binding]; metal-binding site 481805009048 active site 481805009049 I-site; other site 481805009050 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805009051 glutathione ABC transporter permease GsiD; Provisional; Region: PRK15082 481805009052 N-terminal TM domain of oligopeptide transport permease C; Region: OppC_N; pfam12911 481805009053 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805009054 dimer interface [polypeptide binding]; other site 481805009055 conserved gate region; other site 481805009056 putative PBP binding loops; other site 481805009057 ABC-ATPase subunit interface; other site 481805009058 glutathione ABC transporter permease GsiC; Provisional; Region: PRK15081 481805009059 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805009060 dimer interface [polypeptide binding]; other site 481805009061 conserved gate region; other site 481805009062 putative PBP binding loops; other site 481805009063 ABC-ATPase subunit interface; other site 481805009064 glutathione ABC transporter substrate-binding protein GsiB; Provisional; Region: PRK15413 481805009065 The substrate-binding component of an uncharacterized ABC-type peptide import system Ylib contains the type 2 periplasmic binding fold; Region: PBP2_Ylib_like; cd08499 481805009066 glutathione transporter ATP-binding protein; Provisional; Region: PRK10261 481805009067 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805009068 Walker A/P-loop; other site 481805009069 ATP binding site [chemical binding]; other site 481805009070 Q-loop/lid; other site 481805009071 ABC transporter signature motif; other site 481805009072 Walker B; other site 481805009073 D-loop; other site 481805009074 H-loop/switch region; other site 481805009075 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 481805009076 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805009077 Walker A/P-loop; other site 481805009078 ATP binding site [chemical binding]; other site 481805009079 Q-loop/lid; other site 481805009080 ABC transporter signature motif; other site 481805009081 Walker B; other site 481805009082 D-loop; other site 481805009083 H-loop/switch region; other site 481805009084 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; pfam08352 481805009085 L-Asparaginase type 2. L-Asparaginase hydrolyzes L-asparagine to L-aspartate and ammonia. The proenzyme undergoes an autoproteolytic cleavage into alpha and beta subunits to expose a threonine residue which becomes the N-terminal residue of the beta...; Region: Asparaginase_2; cd04701 481805009086 catalytic nucleophile [active] 481805009087 molybdopterin biosynthesis protein MoeA; Provisional; Region: PRK10680 481805009088 MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoeA; cd00887 481805009089 dimer interface [polypeptide binding]; other site 481805009090 putative functional site; other site 481805009091 putative MPT binding site; other site 481805009092 molybdopterin biosynthesis protein MoeB; Provisional; Region: PRK05690 481805009093 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 481805009094 ATP binding site [chemical binding]; other site 481805009095 substrate interface [chemical binding]; other site 481805009096 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 481805009097 active site 481805009098 intersubunit interactions; other site 481805009099 catalytic residue [active] 481805009100 glycyl-radical enzyme activating protein family; Region: PFLE_PFLC; TIGR02494 481805009101 glycyl radical enzyme, PFL2/glycerol dehydratase family; Region: PFL2-3; TIGR01774 481805009102 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 481805009103 dimer interface [polypeptide binding]; other site 481805009104 active site 481805009105 glycine loop; other site 481805009106 Cof subfamily of IIB subfamily of haloacid dehalogenase superfamily; Region: Cof-subfamily; TIGR00099 481805009107 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805009108 active site 481805009109 motif I; other site 481805009110 motif II; other site 481805009111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805009112 haloacid dehalogenase-like hydrolase; Region: HAD; cl17202 481805009113 ABC transporter ATP-binding protein; Provisional; Region: PRK15064 481805009114 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805009115 Walker A/P-loop; other site 481805009116 ATP binding site [chemical binding]; other site 481805009117 Q-loop/lid; other site 481805009118 ABC transporter signature motif; other site 481805009119 Walker B; other site 481805009120 D-loop; other site 481805009121 H-loop/switch region; other site 481805009122 ABC transporter; Region: ABC_tran_2; pfam12848 481805009123 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481805009124 L,D-transpeptidase; Provisional; Region: PRK10260 481805009125 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 481805009126 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 481805009127 Putative anion permease YbiR. Based on sequence similarity, YbiR proteins are predicted to function as anion translocating permeases in eubacteria, archaea and plants. They belong to ArsB/NhaD superfamily of permeases that have been shown to translocate...; Region: YbiR_permease; cd01117 481805009128 transmembrane helices; other site 481805009129 manganese transport regulator MntR; Provisional; Region: PRK11050 481805009130 Iron dependent repressor, N-terminal DNA binding domain; Region: Fe_dep_repress; pfam01325 481805009131 Iron dependent repressor, metal binding and dimerisation domain; Region: Fe_dep_repr_C; pfam02742 481805009132 Predicted membrane-associated, metal-dependent hydrolase [General function prediction only]; Region: COG2194 481805009133 Sulfatase; Region: Sulfatase; pfam00884 481805009134 outer membrane protein X; Provisional; Region: ompX; PRK09408 481805009135 threonine and homoserine efflux system; Provisional; Region: PRK10532 481805009136 EamA-like transporter family; Region: EamA; pfam00892 481805009137 DNA-binding ferritin-like protein (oxidative damage protectant) [Inorganic ion transport and metabolism]; Region: Dps; COG0783 481805009138 DPS protein, ferritin-like diiron-binding domain; Region: DPS; cd01043 481805009139 dimerization interface [polypeptide binding]; other site 481805009140 DPS ferroxidase diiron center [ion binding]; other site 481805009141 ion pore; other site 481805009142 glutamine ABC transporter periplasmic protein; Reviewed; Region: glnH; PRK09495 481805009143 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805009144 substrate binding pocket [chemical binding]; other site 481805009145 membrane-bound complex binding site; other site 481805009146 hinge residues; other site 481805009147 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 481805009148 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805009149 dimer interface [polypeptide binding]; other site 481805009150 conserved gate region; other site 481805009151 putative PBP binding loops; other site 481805009152 ABC-ATPase subunit interface; other site 481805009153 glutamine ABC transporter ATP-binding protein; Reviewed; Region: glnQ; PRK09493 481805009154 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 481805009155 Walker A/P-loop; other site 481805009156 ATP binding site [chemical binding]; other site 481805009157 Q-loop/lid; other site 481805009158 ABC transporter signature motif; other site 481805009159 Walker B; other site 481805009160 D-loop; other site 481805009161 H-loop/switch region; other site 481805009162 putative mechanosensitive channel protein; Provisional; Region: PRK11465 481805009163 Mechanosensitive ion channel; Region: MS_channel; pfam00924 481805009164 23S rRNA mA1618 methyltransferase; Provisional; Region: PRK11727 481805009165 Protein of unknown function (DUF890); Region: Methyltransf_10; pfam05971 481805009166 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 481805009167 catecholate siderophore receptor Fiu; Provisional; Region: PRK09840 481805009168 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 481805009169 N-terminal plug; other site 481805009170 ligand-binding site [chemical binding]; other site 481805009171 Fe(II)-dependent oxygenase superfamily protein; Provisional; Region: PRK05467 481805009172 hypothetical protein; Provisional; Region: PRK11019 481805009173 hypothetical protein; Provisional; Region: PRK10259 481805009174 putative dehydrogenase; Provisional; Region: PRK10098 481805009175 glycosyl transferase family protein; Provisional; Region: PRK08136 481805009176 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 481805009177 ATP-dependent DNA helicase DinG; Provisional; Region: dinG; PRK11747 481805009178 DEAD_2; Region: DEAD_2; pfam06733 481805009179 Helicase C-terminal domain; Region: Helicase_C_2; pfam13307 481805009180 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3236 481805009181 helicase 45; Provisional; Region: PTZ00424 481805009182 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 481805009183 ATP binding site [chemical binding]; other site 481805009184 Mg++ binding site [ion binding]; other site 481805009185 motif III; other site 481805009186 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805009187 nucleotide binding region [chemical binding]; other site 481805009188 ATP-binding site [chemical binding]; other site 481805009189 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11552 481805009190 Domain of unknown function (DUF1956); Region: DUF1956; pfam09209 481805009191 putative efflux pump membrane fusion protein; Provisional; Region: PRK03598 481805009192 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481805009193 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805009194 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481805009195 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481805009196 Walker A/P-loop; other site 481805009197 ATP binding site [chemical binding]; other site 481805009198 Q-loop/lid; other site 481805009199 ABC transporter signature motif; other site 481805009200 Walker B; other site 481805009201 D-loop; other site 481805009202 H-loop/switch region; other site 481805009203 ABC-type Na+ transport system, ATPase component [Energy production and conversion / Inorganic ion transport and metabolism]; Region: NatA; COG4555 481805009204 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481805009205 Walker A/P-loop; other site 481805009206 ATP binding site [chemical binding]; other site 481805009207 Q-loop/lid; other site 481805009208 ABC transporter signature motif; other site 481805009209 Walker B; other site 481805009210 D-loop; other site 481805009211 H-loop/switch region; other site 481805009212 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 481805009213 ABC-2 family transporter protein; Region: ABC2_membrane_2; pfam12679 481805009214 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 481805009215 ABC-2 type transporter; Region: ABC2_membrane; pfam01061 481805009216 Putative inner membrane protein YbhQ; Region: YbhQ; pfam11076 481805009217 Metal-dependent hydrolase [General function prediction only]; Region: ElsH; COG3568 481805009218 putative catalytic site [active] 481805009219 putative metal binding site [ion binding]; other site 481805009220 putative phosphate binding site [ion binding]; other site 481805009221 cardiolipin synthase 2; Provisional; Region: PRK11263 481805009222 Catalytic domain, repeat 1, of bacterial cardiolipin synthase and similar proteins; Region: PLDc_CLS_1; cd09110 481805009223 putative active site [active] 481805009224 catalytic site [active] 481805009225 Catalytic domain, repeat 2, of Escherichia coli cardiolipin synthase ybhO and similar proteins; Region: PLDc_ybhO_like_2; cd09159 481805009226 putative active site [active] 481805009227 catalytic site [active] 481805009228 Predicted integral membrane protein [Function unknown]; Region: COG0392 481805009229 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 481805009230 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 481805009231 Integral membrane protein, interacts with FtsH [General function prediction only]; Region: COG0670 481805009232 Bacterial BAX inhibitor (BI)-1/YccA-like proteins; Region: BI-1-like_bacterial; cd10432 481805009233 MoaE family. Members of this family are involved in biosynthesis of the molybdenum cofactor (Moco), an essential cofactor for a diverse group of redox enzymes. Moco biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and...; Region: MoaE; cd00756 481805009234 MoaE homodimer interface [polypeptide binding]; other site 481805009235 MoaD interaction [polypeptide binding]; other site 481805009236 active site residues [active] 481805009237 Ubiquitin domain of MoaD-like proteins; Region: MoaD; cd00754 481805009238 MoaE interaction surface [polypeptide binding]; other site 481805009239 MoeB interaction surface [polypeptide binding]; other site 481805009240 thiocarboxylated glycine; other site 481805009241 MoaC family, prokaryotic and eukaryotic. Members of this family are involved in molybdenum cofactor (Moco) biosynthesis, an essential cofactor of a diverse group of redox enzymes. MoaC, a small hexameric protein, converts, together with MoaA, a guanosine...; Region: MoaC_PE; cd01420 481805009242 trimer interface [polypeptide binding]; other site 481805009243 dimer interface [polypeptide binding]; other site 481805009244 putative active site [active] 481805009245 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 481805009246 MPT binding site; other site 481805009247 trimer interface [polypeptide binding]; other site 481805009248 molybdenum cofactor biosynthesis protein A; Reviewed; Region: moaA; PRK00164 481805009249 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805009250 FeS/SAM binding site; other site 481805009251 Molybdenum Cofactor Synthesis C; Region: Mob_synth_C; pfam06463 481805009252 conserved hypothetical protein, cofD-related; Region: CofD_related; TIGR01826 481805009253 family of mostly uncharacterized proteins similar to B.subtilis YvcK; Region: YvcK_like; cd07187 481805009254 putative substrate binding pocket [chemical binding]; other site 481805009255 dimer interface [polypeptide binding]; other site 481805009256 phosphate binding site [ion binding]; other site 481805009257 excinuclease ABC subunit B; Provisional; Region: PRK05298 481805009258 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481805009259 ATP binding site [chemical binding]; other site 481805009260 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805009261 nucleotide binding region [chemical binding]; other site 481805009262 ATP-binding site [chemical binding]; other site 481805009263 Ultra-violet resistance protein B; Region: UvrB; pfam12344 481805009264 UvrB/uvrC motif; Region: UVR; pfam02151 481805009265 AAA domain; Region: AAA_26; pfam13500 481805009266 The Fer4_NifH superfamily contains a variety of proteins which share a common ATP-binding domain. Functionally, proteins in this superfamily use the energy from hydrolysis of NTP to transfer electron or ion; Region: Fer4_NifH; cl17203 481805009267 Dethiobiotin synthetase (DTBS) is the penultimate enzyme in the biotin biosynthesis pathway in Escherichia coli and other microorganisms. The enzyme catalyzes formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (DAPA) and...; Region: DTBS; cd03109 481805009268 ADP binding site [chemical binding]; other site 481805009269 biotin biosynthesis protein BioC; Region: BioC; TIGR02072 481805009270 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805009271 S-adenosylmethionine binding site [chemical binding]; other site 481805009272 pyridoxal phosphate-dependent acyltransferase, putative; Region: gly_Cac_T_rel; TIGR01825 481805009273 KBL_like; this family belongs to the pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to serine palmitoyltransferase (SPT), 5-aminolevulinate synthase (ALAS); Region: KBL_like; cd06454 481805009274 substrate-cofactor binding pocket; other site 481805009275 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805009276 catalytic residue [active] 481805009277 biotin synthase; Provisional; Region: PRK15108 481805009278 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805009279 FeS/SAM binding site; other site 481805009280 Biotin and Thiamin Synthesis associated domain; Region: BATS; smart00876 481805009281 adenosylmethionine--8-amino-7-oxononanoate transaminase; Validated; Region: PRK07986 481805009282 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 481805009283 inhibitor-cofactor binding pocket; inhibition site 481805009284 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805009285 catalytic residue [active] 481805009286 PhosphatidylEthanolamine-Binding Protein (PEBP) domain present in bacteria and archaea; Region: PEBP_bact_arch; cd00865 481805009287 substrate binding site [chemical binding]; other site 481805009288 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805009289 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805009290 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805009291 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 481805009292 Lambda Phage CIII; Region: Lambda_CIII; pfam02061 481805009293 Bacteriophage lambda Kil protein; Region: Lambda_Kil; pfam06301 481805009294 Host-nuclease inhibitor protein Gam; Region: Gam; pfam06064 481805009295 phage recombination protein Bet; Region: bet_lambda; TIGR01913 481805009296 YqaJ-like viral recombinase domain; Region: YqaJ; pfam09588 481805009297 Protein of unknown function (DUF1317); Region: DUF1317; pfam07026 481805009298 Protein of unknown function (DUF1382); Region: DUF1382; pfam07131 481805009299 DksA-like zinc finger domain containing protein; Region: PHA00080 481805009300 Ead/Ea22-like protein; Region: Ead_Ea22; pfam13935 481805009301 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805009302 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805009303 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805009304 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805009305 Hypothetical protein (DUF2513); Region: DUF2513; pfam10711 481805009306 Excisionase-like protein; Region: Exc; pfam07825 481805009307 Bacteriophage lambda integrase, N-terminal domain; Region: Phage_integ_N; pfam09003 481805009308 Phage integrase, N-terminal SAM-like domain; Region: Phage_integr_N; cl12235 481805009309 Integrase [DNA replication, recombination, and repair]; Region: XerC; COG0582 481805009310 Lambda integrase, C-terminal catalytic domain. Lambda-type integrases catalyze site-specific integration and excision of temperate bacteriophages and other mobile genetic elements to and from the bacterial host chromosome. They belong to the superfamily...; Region: INT_Lambda_C; cd00800 481805009311 dimer interface [polypeptide binding]; other site 481805009312 active site 481805009313 Int/Topo IB signature motif; other site 481805009314 acyl-CoA thioesterase; Provisional; Region: PRK10531 481805009315 putative pectinesterase; Region: PLN02432; cl01911 481805009316 putative hydratase; Provisional; Region: PRK11413 481805009317 Aconitase catalytic domain; Aconitase catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle; Region: Aconitase; cl00285 481805009318 substrate binding site [chemical binding]; other site 481805009319 ligand binding site [chemical binding]; other site 481805009320 Aconitase swivel domain. Aconitase (aconitate hydratase) catalyzes the reversible isomerization of citrate and isocitrate as part of the TCA cycle. This is the aconitase swivel domain, which undergoes swivelling conformational change in the enzyme...; Region: Aconitase_swivel; cl00215 481805009321 substrate binding site [chemical binding]; other site 481805009322 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 481805009323 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 481805009324 transmembrane helices; other site 481805009325 PrpF protein; Region: PrpF; pfam04303 481805009326 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481805009327 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805009328 TThe C-terminal substrate binding domain of an uncharacterized LysR-type transcriptional regulator, contains the type 2 periplasmic binding fold; Region: PBP2_LTTR_like_4; cd08440 481805009329 putative dimerization interface [polypeptide binding]; other site 481805009330 6-phosphogluconolactonase; Provisional; Region: PRK11028 481805009331 pyridoxal phosphate (PLP) phosphatase; Provisional; Region: PRK10530 481805009332 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805009333 motif II; other site 481805009334 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805009335 molybdate transporter ATP-binding protein; Provisional; Region: modC; PRK11144 481805009336 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805009337 Walker A/P-loop; other site 481805009338 ATP binding site [chemical binding]; other site 481805009339 Q-loop/lid; other site 481805009340 ABC transporter signature motif; other site 481805009341 Walker B; other site 481805009342 D-loop; other site 481805009343 H-loop/switch region; other site 481805009344 molybdenum-pterin binding domain; Region: Mop; TIGR00638 481805009345 ABC-type sulfate transport system, permease component [Posttranslational modification, protein turnover, chaperones]; Region: CysU; COG0555 481805009346 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805009347 putative PBP binding loops; other site 481805009348 ABC-ATPase subunit interface; other site 481805009349 molybdate transporter periplasmic protein; Provisional; Region: modA; PRK10677 481805009350 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805009351 substrate binding pocket [chemical binding]; other site 481805009352 membrane-bound complex binding site; other site 481805009353 hinge residues; other site 481805009354 Protein of unknown function (DUF2592); Region: DUF2592; pfam10766 481805009355 DNA-binding transcriptional regulator ModE; Provisional; Region: PRK10676 481805009356 N-terminal domain of molybdenum-binding protein [General function prediction only]; Region: ModE; COG2005 481805009357 molybdenum-pterin binding domain; Region: Mop; TIGR00638 481805009358 TOBE domain; Region: TOBE; pfam03459 481805009359 putative molybdenum transport ATP-binding protein ModF; Provisional; Region: PRK10938 481805009360 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cd00267 481805009361 Walker A/P-loop; other site 481805009362 ATP binding site [chemical binding]; other site 481805009363 Q-loop/lid; other site 481805009364 ABC transporter signature motif; other site 481805009365 Walker B; other site 481805009366 D-loop; other site 481805009367 H-loop/switch region; other site 481805009368 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805009369 Walker A/P-loop; other site 481805009370 ATP binding site [chemical binding]; other site 481805009371 Q-loop/lid; other site 481805009372 ABC transporter signature motif; other site 481805009373 Walker B; other site 481805009374 D-loop; other site 481805009375 H-loop/switch region; other site 481805009376 UDP-galactose-4-epimerase; Provisional; Region: PRK10675 481805009377 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 481805009378 NAD binding site [chemical binding]; other site 481805009379 homodimer interface [polypeptide binding]; other site 481805009380 active site 481805009381 substrate binding site [chemical binding]; other site 481805009382 galactose-1-phosphate uridylyltransferase; Provisional; Region: PRK11720 481805009383 Galactose-1-phosphate uridyl transferase (GalT): This enzyme plays a key role in galactose metabolism by catalysing the transfer of a uridine 5'-phosphoryl group from UDP-galactose 1-phosphate. The structure of E.coli GalT reveals that the enzyme...; Region: GalT; cd00608 481805009384 dimer interface [polypeptide binding]; other site 481805009385 active site 481805009386 galactokinase; Provisional; Region: PRK05101 481805009387 Galactokinase galactose-binding signature; Region: GalKase_gal_bdg; pfam10509 481805009388 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 481805009389 galactose mutarotase_like; Region: galactose_mutarotase_like; cd09019 481805009390 active site 481805009391 catalytic residues [active] 481805009392 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 481805009393 catalytic core [active] 481805009394 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 481805009395 phospho-2-dehydro-3-deoxyheptonate aldolase; Validated; Region: PRK09261 481805009396 DAHP synthetase I family; Region: DAHP_synth_1; pfam00793 481805009397 YbgS-like protein; Region: YbgS; pfam13985 481805009398 zinc transporter ZitB; Provisional; Region: PRK03557 481805009399 nicotinamide riboside transporter PnuC; Provisional; Region: PRK15397 481805009400 quinolinate synthetase; Provisional; Region: PRK09375 481805009401 tol-pal system protein YbgF; Provisional; Region: PRK10803 481805009402 Tetratricopeptide repeat; Region: TPR_6; pfam13174 481805009403 Tetratricopeptide repeat; Region: TPR_6; pfam13174 481805009404 peptidoglycan-associated outer membrane lipoprotein; Provisional; Region: PRK10802 481805009405 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 481805009406 ligand binding site [chemical binding]; other site 481805009407 translocation protein TolB; Provisional; Region: tolB; PRK03629 481805009408 TolB amino-terminal domain; Region: TolB_N; pfam04052 481805009409 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 481805009410 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 481805009411 WD40-like Beta Propeller Repeat; Region: PD40; pfam07676 481805009412 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 481805009413 cell envelope integrity inner membrane protein TolA; Provisional; Region: tolA; PRK09510 481805009414 TolA C-terminal; Region: TolA; pfam06519 481805009415 Biopolymer transport protein [Intracellular trafficking and secretion]; Region: ExbD; COG0848 481805009416 colicin uptake protein TolR; Provisional; Region: PRK11024 481805009417 colicin uptake protein TolQ; Provisional; Region: PRK10801 481805009418 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 481805009419 active site 481805009420 hypothetical protein; Provisional; Region: PRK10588 481805009421 Membrane bound YbgT-like protein; Region: YbgT_YccB; cl02039 481805009422 cytochrome d ubiquinol oxidase subunit 2; Provisional; Region: PRK15003 481805009423 Cytochrome bd-type quinol oxidase, subunit 2 [Energy production and conversion]; Region: AppB; COG1294 481805009424 cytochrome d terminal oxidase subunit 1; Provisional; Region: PRK15097 481805009425 Bacterial Cytochrome Ubiquinol Oxidase; Region: Bac_Ubq_Cox; cl00562 481805009426 alpha-mannosidase; Provisional; Region: PRK09819 481805009427 N-terminal catalytic domain of Escherichia coli alpha-mannosidase MngB and its bacterial homologs; glycoside hydrolase family 38 (GH38); Region: GH38N_AMII_EcMngB_like; cd10815 481805009428 active site 481805009429 metal binding site [ion binding]; metal-binding site 481805009430 catalytic site [active] 481805009431 Alpha mannosidase, middle domain; Region: Alpha-mann_mid; smart00872 481805009432 PTS system 2-O-a-mannosyl-D-glycerate specific transporter subunit IIABC; Provisional; Region: PRK09765 481805009433 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481805009434 active site 481805009435 phosphorylation site [posttranslational modification] 481805009436 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 481805009437 active site 481805009438 P-loop; other site 481805009439 phosphorylation site [posttranslational modification] 481805009440 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 481805009441 DNA-binding transcriptional repressor MngR; Provisional; Region: PRK09764 481805009442 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805009443 DNA-binding site [nucleotide binding]; DNA binding site 481805009444 UTRA domain; Region: UTRA; pfam07702 481805009445 succinyl-CoA synthetase subunit alpha; Validated; Region: PRK05678 481805009446 CoA binding domain; Region: CoA_binding; smart00881 481805009447 CoA-ligase; Region: Ligase_CoA; pfam00549 481805009448 succinyl-CoA synthetase subunit beta; Provisional; Region: sucC; PRK00696 481805009449 ATP-grasp domain; Region: ATP-grasp_2; pfam08442 481805009450 CoA-ligase; Region: Ligase_CoA; pfam00549 481805009451 dihydrolipoamide succinyltransferase; Validated; Region: PRK05704 481805009452 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 481805009453 E3 interaction surface; other site 481805009454 lipoyl attachment site [posttranslational modification]; other site 481805009455 e3 binding domain; Region: E3_binding; pfam02817 481805009456 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 481805009457 2-oxoglutarate dehydrogenase E1 component; Reviewed; Region: sucA; PRK09404 481805009458 Thiamine pyrophosphate (TPP) family, E1 of OGDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the 2-oxoglutarate dehydrogenase multienzyme complex (OGDC). OGDC catalyzes the oxidative decarboxylation of...; Region: TPP_E1_OGDC_like; cd02016 481805009459 TPP-binding site [chemical binding]; other site 481805009460 Transketolase, pyrimidine binding domain; Region: Transket_pyr; pfam02779 481805009461 dimer interface [polypeptide binding]; other site 481805009462 PYR/PP interface [polypeptide binding]; other site 481805009463 TPP binding site [chemical binding]; other site 481805009464 succinate dehydrogenase iron-sulfur subunit; Reviewed; Region: sdhB; PRK05950 481805009465 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 481805009466 succinate dehydrogenase flavoprotein subunit; Reviewed; Region: sdhA; PRK08958 481805009467 L-aspartate oxidase; Provisional; Region: PRK06175 481805009468 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 481805009469 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase D (SdhD) subunit; SQR catalyzes the oxidation of succinate to fumarate coupled to the reduction of quinone to quinol. E. coli SQR, a member of this subfamily, reduces the...; Region: SQR_TypeC_SdhD; cd03494 481805009470 SdhC subunit interface [polypeptide binding]; other site 481805009471 proximal heme binding site [chemical binding]; other site 481805009472 cardiolipin binding site; other site 481805009473 Iron-sulfur protein interface; other site 481805009474 proximal quinone binding site [chemical binding]; other site 481805009475 Succinate:quinone oxidoreductase (SQR) Type C subfamily, Succinate dehydrogenase C (SdhC) subunit; composed of bacterial SdhC and eukaryotic large cytochrome b binding (CybL) proteins. SQR catalyzes the oxidation of succinate to fumarate coupled to the...; Region: SQR_TypeC_SdhC; cd03499 481805009476 Iron-sulfur protein interface; other site 481805009477 proximal quinone binding site [chemical binding]; other site 481805009478 SdhD (CybS) interface [polypeptide binding]; other site 481805009479 proximal heme binding site [chemical binding]; other site 481805009480 Escherichia coli (Ec) citrate synthase (CS) GltA_like. CS catalyzes the condensation of acetyl coenzyme A (AcCoA) and oxalacetate (OAA) to form citrate and coenzyme A (CoA), the first step in the citric acid cycle (TCA or Krebs cycle). The overall CS...; Region: EcCS_like; cd06114 481805009481 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 481805009482 dimer interface [polypeptide binding]; other site 481805009483 active site 481805009484 citrylCoA binding site [chemical binding]; other site 481805009485 NADH binding [chemical binding]; other site 481805009486 cationic pore residues; other site 481805009487 oxalacetate/citrate binding site [chemical binding]; other site 481805009488 coenzyme A binding site [chemical binding]; other site 481805009489 catalytic triad [active] 481805009490 P pilus assembly protein, pilin FimA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimA; COG3539 481805009491 P pilus assembly protein, porin PapC [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimD; COG3188 481805009492 PapC N-terminal domain; Region: PapC_N; pfam13954 481805009493 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 481805009494 PapC C-terminal domain; Region: PapC_C; pfam13953 481805009495 P pilus assembly protein, chaperone PapD [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FimC; COG3121 481805009496 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 481805009497 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 481805009498 Fimbrial protein; Region: Fimbrial; pfam00419 481805009499 Putative ammonia monooxygenase [General function prediction only]; Region: AbrB; COG3180 481805009500 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 481805009501 membrane protein AbrB duplication; Region: Gneg_AbrB_dup; TIGR03082 481805009502 endonuclease VIII; Provisional; Region: PRK10445 481805009503 N-terminal domain of Escherichia coli Nei/endonuclease VIII and related DNA glycosylases; Region: EcNei-like_N; cd08965 481805009504 DNA binding site [nucleotide binding] 481805009505 catalytic residue [active] 481805009506 putative catalytic residues [active] 481805009507 H2TH interface [polypeptide binding]; other site 481805009508 intercalation triad [nucleotide binding]; other site 481805009509 substrate specificity determining residue; other site 481805009510 Formamidopyrimidine-DNA glycosylase H2TH domain; Region: H2TH; pfam06831 481805009511 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 481805009512 Escherichia coli putative lactam utilization protein YbgL and similar proteins; Region: LamB_YcsF_YbgL_like; cd10800 481805009513 putative active site [active] 481805009514 biotin-dependent carboxylase uncharacterized domain; Region: urea_amlyse_rel; TIGR00724 481805009515 Allophanate hydrolase subunit 1; Region: AHS1; pfam02682 481805009516 sensor histidine kinase inhibitor, KipI family; Region: TIGR00370 481805009517 Uncharacterized conserved protein [Function unknown]; Region: COG0327 481805009518 metal-binding protein; Provisional; Region: PRK10799 481805009519 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 481805009520 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805009521 putative substrate translocation pore; other site 481805009522 POT family; Region: PTR2; pfam00854 481805009523 deoxyribodipyrimidine photolyase; Provisional; Region: PRK10674 481805009524 DNA photolyase; Region: DNA_photolyase; pfam00875 481805009525 hypothetical protein; Provisional; Region: PRK10167 481805009526 Uncharacterized conserved protein [Function unknown]; Region: COG3272 481805009527 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 481805009528 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 481805009529 Transposase [DNA replication, recombination, and repair]; Region: COG5433 481805009530 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 481805009531 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 481805009532 Transposase [DNA replication, recombination, and repair]; Region: COG5433 481805009533 Transposase [DNA replication, recombination, and repair]; Region: COG5433 481805009534 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805009535 RHS protein; Region: RHS; pfam03527 481805009536 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 481805009537 PAAR motif; Region: PAAR_motif; cl15808 481805009538 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805009539 RHS Repeat; Region: RHS_repeat; pfam05593 481805009540 RHS Repeat; Region: RHS_repeat; pfam05593 481805009541 RHS Repeat; Region: RHS_repeat; pfam05593 481805009542 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805009543 RHS Repeat; Region: RHS_repeat; pfam05593 481805009544 RHS Repeat; Region: RHS_repeat; pfam05593 481805009545 RHS protein; Region: RHS; pfam03527 481805009546 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 481805009547 Protein of unknown function (DUF2517); Region: DUF2517; pfam10725 481805009548 potassium-transporting ATPase subunit A; Provisional; Region: PRK05482 481805009549 potassium-transporting ATPase subunit B; Provisional; Region: PRK01122 481805009550 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 481805009551 potassium-transporting ATPase subunit C; Reviewed; Region: PRK00315 481805009552 sensor protein KdpD; Provisional; Region: PRK10490 481805009553 Osmosensitive K+ channel His kinase sensor domain; Region: KdpD; pfam02702 481805009554 USP domain is located between the N-terminal sensor domain and C-terminal catalytic domain of this Osmosensitive K+ channel histidine kinase family. The family of KdpD sensor kinase proteins regulates the kdpFABC operon responsible for potassium...; Region: USP_OKCHK; cd01987 481805009555 Ligand Binding Site [chemical binding]; other site 481805009556 Domain of unknown function (DUF4118); Region: DUF4118; pfam13493 481805009557 GAF domain; Region: GAF_3; pfam13492 481805009558 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805009559 dimer interface [polypeptide binding]; other site 481805009560 phosphorylation site [posttranslational modification] 481805009561 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805009562 ATP binding site [chemical binding]; other site 481805009563 Mg2+ binding site [ion binding]; other site 481805009564 G-X-G motif; other site 481805009565 DNA-binding transcriptional activator KdpE; Provisional; Region: PRK10529 481805009566 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805009567 active site 481805009568 phosphorylation site [posttranslational modification] 481805009569 intermolecular recognition site; other site 481805009570 dimerization interface [polypeptide binding]; other site 481805009571 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805009572 DNA binding site [nucleotide binding] 481805009573 ornithine decarboxylase; Provisional; Region: PRK13578 481805009574 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 481805009575 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 481805009576 homodimer interface [polypeptide binding]; other site 481805009577 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805009578 catalytic residue [active] 481805009579 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 481805009580 putrescine transporter; Provisional; Region: potE; PRK10655 481805009581 Tryptophan/tyrosine permease family; Region: Trp_Tyr_perm; cl17316 481805009582 Protein of unknown function DUF2625; Region: DUF2625; pfam10946 481805009583 phosphoglucomutase, alpha-D-glucose phosphate-specific; Region: pgm; TIGR01132 481805009584 This bacterial PGM-like (phosphoglucomutase-like) protein of unknown function belongs to the alpha-D-phosphohexomutase superfamily. The alpha-D-phosphohexomutases include several related enzymes that catalyze a reversible intramolecular phosphoryl...; Region: PGM_like3; cd05801 481805009585 active site 481805009586 substrate binding site [chemical binding]; other site 481805009587 metal binding site [ion binding]; metal-binding site 481805009588 replication initiation regulator SeqA; Provisional; Region: PRK11187 481805009589 acyl-CoA esterase; Provisional; Region: PRK10673 481805009590 PGAP1-like protein; Region: PGAP1; pfam07819 481805009591 LexA regulated protein; Provisional; Region: PRK11675 481805009592 flavodoxin FldA; Validated; Region: PRK09267 481805009593 ferric uptake regulator; Provisional; Region: fur; PRK09462 481805009594 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 481805009595 metal binding site 2 [ion binding]; metal-binding site 481805009596 putative DNA binding helix; other site 481805009597 metal binding site 1 [ion binding]; metal-binding site 481805009598 dimer interface [polypeptide binding]; other site 481805009599 structural Zn2+ binding site [ion binding]; other site 481805009600 YbfN-like lipoprotein; Region: YbfN; pfam13982 481805009601 outer membrane porin, OprD family; Region: OprD; pfam03573 481805009602 glutaminyl-tRNA synthetase; Provisional; Region: PRK05347 481805009603 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 481805009604 active site 481805009605 HIGH motif; other site 481805009606 nucleotide binding site [chemical binding]; other site 481805009607 catalytic core domain of glutaminyl-tRNA synthetase; Region: GlnRS_core; cd00807 481805009608 KMSKS motif; other site 481805009609 tRNA synthetases class I (E and Q), anti-codon binding domain; Region: tRNA-synt_1c_C; pfam03950 481805009610 PTS system N-acetyl glucosamine specific transporter subunits IIABC; Provisional; Region: PRK10255 481805009611 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 481805009612 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 481805009613 active site turn [active] 481805009614 phosphorylation site [posttranslational modification] 481805009615 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 481805009616 HPr interaction site; other site 481805009617 glycerol kinase (GK) interaction site [polypeptide binding]; other site 481805009618 active site 481805009619 phosphorylation site [posttranslational modification] 481805009620 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 481805009621 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 481805009622 active site 481805009623 trimer interface [polypeptide binding]; other site 481805009624 allosteric site; other site 481805009625 active site lid [active] 481805009626 hexamer (dimer of trimers) interface [polypeptide binding]; other site 481805009627 N-acetylglucosamine-6-phosphate deacetylase; Region: nagA; TIGR00221 481805009628 N-acetylglucosamine-6-phosphate deacetylase, NagA, catalyzes the hydrolysis of the N-acetyl group of N-acetyl-glucosamine-6-phosphate (GlcNAc-6-P) to glucosamine 6-phosphate and acetate. This is the first committed step in the biosynthetic pathway to...; Region: NagA; cd00854 481805009629 active site 481805009630 dimer interface [polypeptide binding]; other site 481805009631 MarR family; Region: MarR; pfam01047 481805009632 Transcriptional regulator/sugar kinase [Transcription / Carbohydrate transport and metabolism]; Region: NagC; COG1940 481805009633 ROK family; Region: ROK; pfam00480 481805009634 UMP phosphatase; Provisional; Region: PRK10444 481805009635 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805009636 active site 481805009637 motif I; other site 481805009638 motif II; other site 481805009639 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805009640 asparagine synthetase B; Provisional; Region: asnB; PRK09431 481805009641 Glutamine amidotransferases class-II (GATase) asparagine synthase_B type. Asparagine synthetase B catalyses the ATP-dependent conversion of aspartate to asparagine. This enzyme is a homodimer, with each monomer composed of a glutaminase domain and a...; Region: AsnB; cd00712 481805009642 active site 481805009643 dimer interface [polypeptide binding]; other site 481805009644 The C-terminal domain of Asparagine Synthase B. This domain is always found associated n-terminal amidotransferase domain. Family members that contain this domain catalyse the conversion of aspartate to asparagine. Asparagine synthetase B catalyzes the...; Region: Asn_Synthase_B_C; cd01991 481805009645 Ligand Binding Site [chemical binding]; other site 481805009646 Molecular Tunnel; other site 481805009647 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase; Reviewed; Region: ubiF; PRK08020 481805009648 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 481805009649 (dimethylallyl)adenosine tRNA methylthiotransferase; Provisional; Region: PRK14325 481805009650 Uncharacterized protein family UPF0004; Region: UPF0004; pfam00919 481805009651 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805009652 FeS/SAM binding site; other site 481805009653 TRAM domain; Region: TRAM; pfam01938 481805009654 Phosphate starvation-inducible protein PhoH, predicted ATPase [Signal transduction mechanisms]; Region: PhoH; COG1702 481805009655 PhoH-like protein; Region: PhoH; pfam02562 481805009656 metal-binding heat shock protein; Provisional; Region: PRK00016 481805009657 magnesium/cobalt efflux protein CorC; Provisional; Region: PRK15094 481805009658 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 481805009659 Transporter associated domain; Region: CorC_HlyC; smart01091 481805009660 apolipoprotein N-acyltransferase; Reviewed; Region: lnt; PRK00302 481805009661 Apolipoprotein N-acyl transferase (class 9 nitrilases); Region: ALP_N-acyl_transferase; cd07571 481805009662 putative active site [active] 481805009663 catalytic triad [active] 481805009664 putative dimer interface [polypeptide binding]; other site 481805009665 Membrane associated serine protease [Amino acid transport and metabolism]; Region: COG0705 481805009666 PQQ-dependent catabolism-associated beta-propeller protein; Region: PQQ_ABC_repeats; TIGR03866 481805009667 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 481805009668 40-residue YVTN family beta-propeller repeat; Region: beta_rpt_yvtn; TIGR02276 481805009669 glutamate and aspartate transporter subunit; Provisional; Region: PRK10797 481805009670 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805009671 substrate binding pocket [chemical binding]; other site 481805009672 membrane-bound complex binding site; other site 481805009673 hinge residues; other site 481805009674 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 481805009675 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805009676 dimer interface [polypeptide binding]; other site 481805009677 conserved gate region; other site 481805009678 putative PBP binding loops; other site 481805009679 ABC-ATPase subunit interface; other site 481805009680 ABC-type arginine transport system, permease component [Amino acid transport and metabolism]; Region: ArtQ; COG4215 481805009681 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805009682 dimer interface [polypeptide binding]; other site 481805009683 conserved gate region; other site 481805009684 putative PBP binding loops; other site 481805009685 ABC-ATPase subunit interface; other site 481805009686 ABC-type polar amino acid transport system, ATPase component [Amino acid transport and metabolism]; Region: GlnQ; COG1126 481805009687 ATP-binding cassette domain of the histidine and glutamine transporters; Region: ABC_HisP_GlnQ; cd03262 481805009688 Walker A/P-loop; other site 481805009689 ATP binding site [chemical binding]; other site 481805009690 Q-loop/lid; other site 481805009691 ABC transporter signature motif; other site 481805009692 Walker B; other site 481805009693 D-loop; other site 481805009694 H-loop/switch region; other site 481805009695 nuc_hydro_IU_UC_XIUA: inosine-uridine preferring, xanthosine-inosine-uridine-adenosine-preferring and, uridine-cytidine preferring nucleoside hydrolases. Nucleoside hydrolases cleave the N-glycosidic bond in nucleosides generating ribose and the...; Region: nuc_hydro_IU_UC_XIUA; cd02651 481805009696 active site 481805009697 tetramer interface [polypeptide binding]; other site 481805009698 Molecular chaperone [Posttranslational modification, protein turnover, chaperones]; Region: DnaK; COG0443 481805009699 Nucleotide-binding domain of Escherichia coli HscC and similar proteins; Region: HscC_like_NBD; cd10235 481805009700 nucleotide binding site [chemical binding]; other site 481805009701 putative NEF/HSP70 interaction site [polypeptide binding]; other site 481805009702 SBD interface [polypeptide binding]; other site 481805009703 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cl02542 481805009704 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 481805009705 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 481805009706 Sel1-like repeats; Region: SEL1; smart00671 481805009707 Sel1-like repeats; Region: SEL1; smart00671 481805009708 Sel1-like repeats; Region: SEL1; smart00671 481805009709 DnaJ molecular chaperone homology domain; Region: DnaJ; smart00271 481805009710 HSP70 interaction site [polypeptide binding]; other site 481805009711 Protein of unknown function (DUF1266); Region: DUF1266; pfam06889 481805009712 Sel1-like repeats; Region: SEL1; smart00671 481805009713 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 481805009714 Sel1-like repeats; Region: SEL1; smart00671 481805009715 Sel1-like repeats; Region: SEL1; smart00671 481805009716 Sel1-like repeats; Region: SEL1; smart00671 481805009717 Sel1-like repeats; Region: SEL1; smart00671 481805009718 Sel1-like repeats; Region: SEL1; smart00671 481805009719 Sel1-like repeats; Region: SEL1; smart00671 481805009720 hypothetical protein; Provisional; Region: PRK11032 481805009721 4-hydroxybenzoate polyprenyltransferase and related prenyltransferases [Coenzyme metabolism]; Region: UbiA; cl00337 481805009722 leucyl-tRNA synthetase; Validated; Region: leuS; PRK00390 481805009723 catalytic core domain of leucyl-tRNA synthetases; Region: LeuRS_core; cd00812 481805009724 HIGH motif; other site 481805009725 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 481805009726 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 481805009727 active site 481805009728 KMSKS motif; other site 481805009729 Anticodon-binding domain of bacterial and eukaryotic mitochondrial leucyl tRNA synthetases; Region: Anticodon_Ia_Leu_BEm; cd07958 481805009730 tRNA binding surface [nucleotide binding]; other site 481805009731 Anticodon-binding domain of class Ia aminoacyl tRNA synthetases and similar domains; Region: Anticodon_Ia_like; cl12020 481805009732 LPS-assembly lipoprotein RlpB; Provisional; Region: PRK10796 481805009733 DNA polymerase III subunit delta; Reviewed; Region: holA; PRK05574 481805009734 DNA polymerase III, delta subunit; Region: DNA_pol3_delta; pfam06144 481805009735 nicotinic acid mononucleotide adenylyltransferase; Provisional; Region: nadD; PRK00071 481805009736 Nicotinamide/nicotinate mononucleotide adenylyltransferase; Region: NMNAT; cd02165 481805009737 active site 481805009738 (T/H)XGH motif; other site 481805009739 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 481805009740 catalytic core [active] 481805009741 ribosome-associated protein; Provisional; Region: PRK11538 481805009742 rRNA large subunit m3Psi methyltransferase RlmH; Region: tRNA_RlmH_YbeA; TIGR00246 481805009743 penicillin-binding protein 2; Provisional; Region: PRK10795 481805009744 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 481805009745 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 481805009746 cell wall shape-determining protein; Provisional; Region: PRK10794 481805009747 rare lipoprotein A; Provisional; Region: PRK10672 481805009748 Rare lipoprotein A (RlpA)-like double-psi beta-barrel; Region: DPBB_1; pfam03330 481805009749 Sporulation related domain; Region: SPOR; pfam05036 481805009750 D-alanyl-D-alanine carboxypeptidase fraction A; Provisional; Region: PRK10793 481805009751 Beta-lactamase enzyme family; Region: Beta-lactamase2; cl17872 481805009752 Penicillin-binding protein 5, C-terminal domain; Region: PBP5_C; smart00936 481805009753 hypothetical protein; Provisional; Region: PRK04998 481805009754 lipoate-protein ligase B; Provisional; Region: PRK14342 481805009755 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 481805009756 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805009757 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 481805009758 substrate binding pocket [chemical binding]; other site 481805009759 dimerization interface [polypeptide binding]; other site 481805009760 lipoyl synthase; Provisional; Region: PRK05481 481805009761 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805009762 FeS/SAM binding site; other site 481805009763 twin arginine translocase protein E; Validated; Region: tatE; PRK03625 481805009764 chromosome condensation membrane protein; Provisional; Region: PRK14196 481805009765 Cold-Shock Protein (CSP) contains an S1-like cold-shock domain (CSD) that is found in eukaryotes, prokaryotes, and archaea. CSP's include the major cold-shock proteins CspA and CspB in bacteria and the eukaryotic gene regulatory factor Y-box...; Region: CSP_CDS; cd04458 481805009766 DNA-binding site [nucleotide binding]; DNA binding site 481805009767 RNA-binding motif; other site 481805009768 phospholipid:lipid A palmitoyltransferase; Provisional; Region: pagP; PRK11045 481805009769 C4-dicarboxylate transporter DcuC; Provisional; Region: dcuC; PRK10654 481805009770 C4-dicarboxylate anaerobic carrier; Region: DcuC; pfam03606 481805009771 two-component response regulator DpiA; Provisional; Region: dpiA; PRK10046 481805009772 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805009773 active site 481805009774 phosphorylation site [posttranslational modification] 481805009775 intermolecular recognition site; other site 481805009776 dimerization interface [polypeptide binding]; other site 481805009777 Transcriptional regulator; Region: CitT; pfam12431 481805009778 sensor histidine kinase DpiB; Provisional; Region: dpiB; PRK15053 481805009779 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481805009780 putative active site [active] 481805009781 heme pocket [chemical binding]; other site 481805009782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805009783 ATP binding site [chemical binding]; other site 481805009784 Mg2+ binding site [ion binding]; other site 481805009785 G-X-G motif; other site 481805009786 Citrate lyase synthetase [Energy production and conversion]; Region: CitC; COG3053 481805009787 Citrate lyase ligase; Region: Citrate_lyase_ligase; cd02169 481805009788 putative active site [active] 481805009789 (T/H)XGH motif; other site 481805009790 Citrate lyase, gamma subunit [Energy production and conversion]; Region: CitD; COG3052 481805009791 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 481805009792 Citrate lyase, alpha subunit [Energy production and conversion]; Region: CitF; COG3051 481805009793 Phosphoribosyl-dephospho-CoA transferase (holo-ACP synthetase) [Coenzyme metabolism / Lipid metabolism]; Region: CitX; COG3697 481805009794 triphosphoribosyl-dephospho-CoA synthase; Provisional; Region: citG; PRK10096 481805009795 Di- and tricarboxylate transporters [Inorganic ion transport and metabolism]; Region: CitT; COG0471 481805009796 Anion permease ArsB/NhaD. These permeases have been shown to translocate sodium, arsenate, antimonite, sulfate and organic anions across biological membranes in all three kingdoms of life. A typical anion permease contains 8-13 transmembrane helices...; Region: ArsB_NhaD_permease; cd00625 481805009797 transmembrane helices; other site 481805009798 Ribonuclease T2 (RNase T2) is a widespread family of secreted RNases found in every organism examined thus far. This family includes RNase Rh, RNase MC1, RNase LE, and self-incompatibility RNases (S-RNases). Plant T2 RNases are expressed during leaf...; Region: RNase_T2_prok; cd01062 481805009799 B1 nucleotide binding pocket [chemical binding]; other site 481805009800 B2 nucleotide binding pocket [chemical binding]; other site 481805009801 CAS motifs; other site 481805009802 active site 481805009803 nucleoside diphosphate kinase regulator; Provisional; Region: PRK05753 481805009804 Transcription elongation factor, GreA/GreB, C-term; Region: GreA_GreB; pfam01272 481805009805 Glutathione-dependent formaldehyde dehydrogenase related proteins, child 1; Region: FDH_like_1; cd08283 481805009806 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 481805009807 NAD binding site [chemical binding]; other site 481805009808 catalytic Zn binding site [ion binding]; other site 481805009809 structural Zn binding site [ion binding]; other site 481805009810 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 481805009811 Ligand Binding Site [chemical binding]; other site 481805009812 alkyl hydroperoxide reductase subunit F; Provisional; Region: PRK15317 481805009813 Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) family, N-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which in turn catalyzes the reduction...; Region: AhpF_NTD_N; cd02974 481805009814 catalytic residue [active] 481805009815 TRX-GRX-like family, Alkyl hydroperoxide reductase F subunit (AhpF) N-terminal domain (NTD) subfamily, C-terminal TRX-fold subdomain; AhpF is a homodimeric flavoenzyme which catalyzes the NADH-dependent reduction of the peroxiredoxin AhpC, which then...; Region: AhpF_NTD_C; cd03026 481805009816 catalytic residues [active] 481805009817 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; cl17500 481805009818 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805009819 alkyl hydroperoxide reductase subunit C; Provisional; Region: PRK10382 481805009820 Peroxiredoxin (PRX) family, Typical 2-Cys PRX subfamily; PRXs are thiol-specific antioxidant (TSA) proteins, which confer a protective role in cells through its peroxidase activity by reducing hydrogen peroxide, peroxynitrite, and organic hydroperoxides; Region: PRX_Typ2cys; cd03015 481805009821 dimer interface [polypeptide binding]; other site 481805009822 decamer (pentamer of dimers) interface [polypeptide binding]; other site 481805009823 catalytic triad [active] 481805009824 peroxidatic and resolving cysteines [active] 481805009825 disulfide isomerase/thiol-disulfide oxidase; Provisional; Region: dsbG; PRK11657 481805009826 DsbA family, DsbC and DsbG subfamily; V-shaped homodimeric proteins containing a redox active CXXC motif imbedded in a TRX fold. They function as protein disulfide isomerases and chaperones in the bacterial periplasm to correct non-native disulfide bonds...; Region: DsbA_DsbC_DsbG; cd03020 481805009827 dimerization domain [polypeptide binding]; other site 481805009828 dimer interface [polypeptide binding]; other site 481805009829 catalytic residues [active] 481805009830 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11482 481805009831 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805009832 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481805009833 Predicted phosphoadenosine phosphosulfate sulfotransferase [General function prediction only]; Region: COG3969 481805009834 This domain is found in phosphoadenosine phosphosulphate (PAPS) reductase enzymes or PAPS sulphotransferase. PAPS reductase is part of the adenine nucleotide alpha hydrolases superfamily also including N type ATP PPases and ATP sulphurylases. A highly...; Region: PAPS_reductase; cd01713 481805009835 Active Sites [active] 481805009836 Domain of unknown function (DUF3440); Region: DUF3440; pfam11922 481805009837 Stage 0 sporulation protein J (antagonist of Soj) containing ParB-like nuclease domain [Transcription]; Region: Spo0J; COG1475 481805009838 ParB-like nuclease domain; Region: ParBc; pfam02195 481805009839 methionine aminotransferase; Validated; Region: PRK09082 481805009840 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481805009841 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805009842 homodimer interface [polypeptide binding]; other site 481805009843 catalytic residue [active] 481805009844 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 481805009845 Glycerol dehydrogenases-like; Region: GlyDH-like1; cd08172 481805009846 putative active site [active] 481805009847 metal binding site [ion binding]; metal-binding site 481805009848 Uncharacterized small protein [Function unknown]; Region: COG2879 481805009849 carbon starvation protein A; Provisional; Region: PRK15015 481805009850 Carbon starvation protein CstA; Region: CstA; pfam02554 481805009851 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 481805009852 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 481805009853 CoenzymeA binding site [chemical binding]; other site 481805009854 subunit interaction site [polypeptide binding]; other site 481805009855 PHB binding site; other site 481805009856 2,3-dihydroxybenzoate-2,3-dehydrogenase; Validated; Region: PRK08220 481805009857 2,3 dihydro-2,3 dihydrozybenzoate dehydrogenases, classical (c) SDRs; Region: DH-DHB-DH_SDR_c; cd05331 481805009858 putative NAD(P) binding site [chemical binding]; other site 481805009859 active site 481805009860 Isochorismatase, also known as 2,3 dihydro-2,3 dihydroxybenzoate synthase, catalyses the conversion of isochorismate, in the presence of water, to 2,3-dihydroxybenzoate and pyruvate, via the hydrolysis of a vinyl ether, an uncommon reaction in biological...; Region: isochorismatase; cd01013 481805009861 hydrophobic substrate binding pocket; other site 481805009862 Isochorismatase family; Region: Isochorismatase; pfam00857 481805009863 active site 481805009864 conserved cis-peptide bond; other site 481805009865 Aryl carrier domain [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3433 481805009866 enterobactin synthase subunit E; Provisional; Region: entE; PRK10946 481805009867 2,3-dihydroxybenzoate-AMP ligase; Region: 23DHB-AMP_lg; cd05920 481805009868 acyl-activating enzyme (AAE) consensus motif; other site 481805009869 active site 481805009870 AMP binding site [chemical binding]; other site 481805009871 substrate binding site [chemical binding]; other site 481805009872 isochorismate synthase EntC; Provisional; Region: PRK15016 481805009873 chorismate binding enzyme; Region: Chorismate_bind; pfam00425 481805009874 iron-enterobactin transporter periplasmic binding protein; Provisional; Region: PRK10957 481805009875 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 481805009876 siderophore binding site; other site 481805009877 enterobactin exporter EntS; Provisional; Region: PRK10489 481805009878 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805009879 putative substrate translocation pore; other site 481805009880 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 481805009881 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481805009882 ABC-ATPase subunit interface; other site 481805009883 dimer interface [polypeptide binding]; other site 481805009884 putative PBP binding regions; other site 481805009885 ABC-type enterobactin transport system, permease component [Inorganic ion transport and metabolism]; Region: FepG; COG4779 481805009886 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481805009887 ABC-ATPase subunit interface; other site 481805009888 dimer interface [polypeptide binding]; other site 481805009889 putative PBP binding regions; other site 481805009890 iron-enterobactin transporter ATP-binding protein; Provisional; Region: PRK10253 481805009891 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 481805009892 Walker A/P-loop; other site 481805009893 ATP binding site [chemical binding]; other site 481805009894 Q-loop/lid; other site 481805009895 ABC transporter signature motif; other site 481805009896 Walker B; other site 481805009897 D-loop; other site 481805009898 H-loop/switch region; other site 481805009899 LPS O-antigen length regulator; Provisional; Region: PRK10381 481805009900 Chain length determinant protein; Region: Wzz; pfam02706 481805009901 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 481805009902 enterobactin synthase subunit F; Provisional; Region: entF; PRK10252 481805009903 The adenylation domain of nonribosomal peptide synthetases (NRPS); Region: A_NRPS; cd05930 481805009904 acyl-activating enzyme (AAE) consensus motif; other site 481805009905 AMP binding site [chemical binding]; other site 481805009906 Phosphopantetheine attachment site; Region: PP-binding; pfam00550 481805009907 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3251 481805009908 enterobactin/ferric enterobactin esterase; Provisional; Region: PRK10439 481805009909 Domain of unknown function (DUF3327); Region: DUF3327; pfam11806 481805009910 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 481805009911 outer membrane receptor FepA; Provisional; Region: PRK13524 481805009912 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 481805009913 N-terminal plug; other site 481805009914 ligand-binding site [chemical binding]; other site 481805009915 phosphopantetheinyltransferase component of enterobactin synthase multienzyme complex; Provisional; Region: PRK10251 481805009916 4'-phosphopantetheinyl transferase superfamily; Region: ACPS; pfam01648 481805009917 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 481805009918 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 481805009919 Hok/gef family; Region: HOK_GEF; pfam01848 481805009920 gamma-glutamyl:cysteine ligase; Provisional; Region: PRK13516 481805009921 carboxylate-amine ligase, YbdK family; Region: gshA_cyan_rel; TIGR02050 481805009922 Protein of unknown function (DUF1158); Region: DUF1158; pfam06643 481805009923 hypothetical protein; Provisional; Region: PRK10250 481805009924 NAD(P)H:FMN oxidoreductase family. This domain catalyzes the reduction of flavin, nitrocompound, quinones and azo compounds using NADH or NADPH as an electron donor. The enzyme is a homodimer, and each monomer binds a FMN as co-factor. This family...; Region: NfsB_like_nitroreductase; cd02149 481805009925 dimer interface [polypeptide binding]; other site 481805009926 FMN binding site [chemical binding]; other site 481805009927 Small-conductance mechanosensitive channel [Cell envelope biogenesis, outer membrane]; Region: MscS; COG0668 481805009928 Mechanosensitive ion channel; Region: MS_channel; pfam00924 481805009929 phenylalanine transporter; Provisional; Region: PRK10249 481805009930 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 481805009931 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 481805009932 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805009933 periplasmic copper-binding protein; Provisional; Region: PRK09838 481805009934 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 481805009935 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 481805009936 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805009937 active site 481805009938 phosphorylation site [posttranslational modification] 481805009939 intermolecular recognition site; other site 481805009940 dimerization interface [polypeptide binding]; other site 481805009941 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805009942 DNA binding site [nucleotide binding] 481805009943 sensor kinase CusS; Provisional; Region: PRK09835 481805009944 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805009945 dimerization interface [polypeptide binding]; other site 481805009946 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805009947 dimer interface [polypeptide binding]; other site 481805009948 phosphorylation site [posttranslational modification] 481805009949 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805009950 ATP binding site [chemical binding]; other site 481805009951 Mg2+ binding site [ion binding]; other site 481805009952 G-X-G motif; other site 481805009953 type VI secretion system Vgr family protein; Region: VI_Rhs_Vgr; TIGR03361 481805009954 Phage late control gene D protein (GPD); Region: Phage_GPD; pfam05954 481805009955 Phage-related baseplate assembly protein; Region: Phage_base_V; pfam04717 481805009956 Putative type VI secretion system Rhs element Vgr; Region: T6SS_Vgr; pfam13296 481805009957 Uncharacterized conserved protein [Function unknown]; Region: COG5435 481805009958 PAAR motif; Region: PAAR_motif; pfam05488 481805009959 RHS Repeat; Region: RHS_repeat; cl11982 481805009960 RHS Repeat; Region: RHS_repeat; pfam05593 481805009961 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 481805009962 RHS Repeat; Region: RHS_repeat; pfam05593 481805009963 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805009964 RHS Repeat; Region: RHS_repeat; pfam05593 481805009965 RHS Repeat; Region: RHS_repeat; cl11982 481805009966 RHS Repeat; Region: RHS_repeat; pfam05593 481805009967 RHS Repeat; Region: RHS_repeat; cl11982 481805009968 YD repeat (two copies); Region: YD_repeat_2x; TIGR01643 481805009969 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 481805009970 DDE_Tnp_1-associated; Region: DDE_Tnp_1_assoc; pfam13808 481805009971 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 481805009972 Transposase [DNA replication, recombination, and repair]; Region: COG5433 481805009973 Transposase [DNA replication, recombination, and repair]; Region: COG5433 481805009974 bacteriophage N4 adsorption protein B; Provisional; Region: nfrB; PRK11234 481805009975 active site 481805009976 Glycosyl transferase family group 2; Region: Glyco_trans_2_3; pfam13632 481805009977 Type II secretion system (T2SS), protein E, N-terminal domain; Region: T2SE_Nter; pfam05157 481805009978 bacteriophage N4 receptor, outer membrane subunit; Provisional; Region: PRK09782 481805009979 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481805009980 TPR motif; other site 481805009981 binding surface 481805009982 Bacteriophage N adsorption protein A C-term; Region: NfrA_C; pfam13283 481805009983 hypothetical protein; Provisional; Region: PRK09936 481805009984 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481805009985 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805009986 transcriptional regulator FimZ; Provisional; Region: PRK09935 481805009987 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805009988 active site 481805009989 phosphorylation site [posttranslational modification] 481805009990 intermolecular recognition site; other site 481805009991 dimerization interface [polypeptide binding]; other site 481805009992 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805009993 DNA binding residues [nucleotide binding] 481805009994 dimerization interface [polypeptide binding]; other site 481805009995 fimbrial-like adhesin protein SfmF; Provisional; Region: PRK09934 481805009996 fimbrial-like adhesin; Provisional; Region: fimH; PRK15199 481805009997 outer membrane usher protein FimD; Provisional; Region: PRK15198 481805009998 PapC N-terminal domain; Region: PapC_N; pfam13954 481805009999 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 481805010000 PapC C-terminal domain; Region: PapC_C; pfam13953 481805010001 fimbrial chaperone protein FimC; Provisional; Region: PRK15195 481805010002 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 481805010003 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 481805010004 type-1 fimbrial protein subunit A; Provisional; Region: PRK15194 481805010005 bifunctional 5,10-methylene-tetrahydrofolate dehydrogenase/ 5,10-methylene-tetrahydrofolate cyclohydrolase; Provisional; Region: PRK10792 481805010006 Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain; Region: THF_DHG_CYH; pfam00763 481805010007 NADP binding domain of methylene-tetrahydrofolate dehydrogenase/cyclohydrolase; Region: NAD_bind_m-THF_DH_Cyclohyd; cd01080 481805010008 homodimer interface [polypeptide binding]; other site 481805010009 NADP binding site [chemical binding]; other site 481805010010 substrate binding site [chemical binding]; other site 481805010011 ribosome-associated protein; Provisional; Region: PRK11507 481805010012 Predicted membrane-bound metal-dependent hydrolases [General function prediction only]; Region: COG1988 481805010013 cysteinyl-tRNA synthetase; Validated; Region: cysS; PRK00260 481805010014 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 481805010015 active site 481805010016 HIGH motif; other site 481805010017 catalytic core domain of cysteinyl tRNA synthetase; Region: CysRS_core; cd00672 481805010018 KMSKS motif; other site 481805010019 Anticodon-binding domain of cysteinyl tRNA synthetases; Region: Anticodon_Ia_Cys; cd07963 481805010020 tRNA binding surface [nucleotide binding]; other site 481805010021 anticodon binding site; other site 481805010022 cyclophilin_EcCYP_like: cyclophilin-type A-like peptidylprolyl cis- trans isomerase (PPIase) domain similar to the cytosolic E. coli cyclophilin A and Streptomyces antibioticus SanCyp18. Compared to the archetypal cyclophilin Human cyclophilin A, these...; Region: cyclophilin_EcCYP_like; cd01920 481805010023 substrate binding site [chemical binding]; other site 481805010024 Escherichia coli YbbF/LpxH and related proteins, metallophosphatase domain; Region: MPP_YbbF-LpxH; cd07398 481805010025 Calcineurin-like phosphoesterase; Region: Metallophos; pfam00149 481805010026 putative active site [active] 481805010027 putative metal binding site [ion binding]; other site 481805010028 Phosphoribosylcarboxyaminoimidazole (NCAIR) mutase [Nucleotide transport and metabolism]; Region: PurE; COG0041 481805010029 phosphoribosylaminoimidazole carboxylase ATPase subunit; Reviewed; Region: PRK06019 481805010030 ATP-grasp domain; Region: ATP-grasp; pfam02222 481805010031 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 481805010032 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 481805010033 putative substrate binding site [chemical binding]; other site 481805010034 nucleotide binding site [chemical binding]; other site 481805010035 nucleotide binding site [chemical binding]; other site 481805010036 homodimer interface [polypeptide binding]; other site 481805010037 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 481805010038 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 481805010039 membrane protein FdrA; Validated; Region: PRK06091 481805010040 CoA binding domain; Region: CoA_binding; pfam02629 481805010041 CoA-ligase; Region: Ligase_CoA; pfam00549 481805010042 ureidoglycolate dehydrogenase; Provisional; Region: PRK15025 481805010043 Transposase domain (DUF772); Region: DUF772; pfam05598 481805010044 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 481805010045 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 481805010046 Uncharacterized protein, possibly involved in glyoxylate utilization [General function prediction only]; Region: GlxB; COG3257 481805010047 Protein of unknown function (DUF861); Region: Cupin_3; cl17594 481805010048 Cupin domain; Region: Cupin_2; cl17218 481805010049 glycerate kinase II; Provisional; Region: PRK09932 481805010050 putative uracil/xanthine transporter; Provisional; Region: PRK11412 481805010051 allantoinase; Provisional; Region: PRK08044 481805010052 L-Hydantoinases (L-HYDs) and Allantoinase (ALN); L-Hydantoinases are a member of the dihydropyrimidinase family, which catalyzes the reversible hydrolytic ring opening of dihydropyrimidines and hydantoins (five-membered cyclic diamides used in...; Region: L-HYD_ALN; cd01315 481805010053 active site 481805010054 nucleobase-cation-symport-1 (NCS1) transporters; solute-binding domain; Region: SLC-NCS1sbd; cd10323 481805010055 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 481805010056 Na binding site [ion binding]; other site 481805010057 substrate binding site [chemical binding]; other site 481805010058 tartronate semialdehyde reductase; Provisional; Region: PRK15059 481805010059 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 481805010060 hydroxypyruvate isomerase; Provisional; Region: PRK09997 481805010061 glyoxylate carboligase; Provisional; Region: PRK11269 481805010062 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 481805010063 PYR/PP interface [polypeptide binding]; other site 481805010064 dimer interface [polypeptide binding]; other site 481805010065 TPP binding site [chemical binding]; other site 481805010066 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 481805010067 Thiamine pyrophosphate (TPP) family, Gcl subfamily, TPP-binding module; composed of proteins similar to Escherichia coli glyoxylate carboligase (Gcl). E. coli glyoxylate carboligase, plays a key role in glyoxylate metabolism where it catalyzes the...; Region: TPP_Gcl; cd02006 481805010068 TPP-binding site [chemical binding]; other site 481805010069 DNA-binding transcriptional repressor AllR; Provisional; Region: PRK10163 481805010070 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 481805010071 Bacterial transcriptional regulator; Region: IclR; pfam01614 481805010072 Ureidoglycolate hydrolase [Nucleotide transport and metabolism]; Region: DAL3; COG3194 481805010073 ureidoglycolate hydrolase; Provisional; Region: PRK03606 481805010074 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 481805010075 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805010076 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481805010077 dimerization interface [polypeptide binding]; other site 481805010078 tRNA 2-selenouridine synthase; Provisional; Region: PRK11784 481805010079 Member of the Rhodanese Homology Domain superfamily. This CD includes several putative ATP /GTP binding proteins including E. coli YbbB; Region: RHOD_YbbB; cd01520 481805010080 active site residue [active] 481805010081 Predicted ABC-type transport system involved in lysophospholipase L1 biosynthesis, permease component [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG3127 481805010082 FtsX-like permease family; Region: FtsX; pfam02687 481805010083 FtsX-like permease family; Region: FtsX; pfam02687 481805010084 putative ABC transporter ATP-binding protein YbbA; Provisional; Region: PRK10584 481805010085 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481805010086 Walker A/P-loop; other site 481805010087 ATP binding site [chemical binding]; other site 481805010088 Q-loop/lid; other site 481805010089 ABC transporter signature motif; other site 481805010090 Walker B; other site 481805010091 D-loop; other site 481805010092 H-loop/switch region; other site 481805010093 Lysophospholipase L1-like subgroup of SGNH-hydrolases. The best characterized member in this family is TesA, an E. coli periplasmic protein with thioesterase, esterase, arylesterase, protease and lysophospholipase activity; Region: Lysophospholipase_L1_like; cd01822 481805010094 active site 481805010095 catalytic triad [active] 481805010096 oxyanion hole [active] 481805010097 switch loop; other site 481805010098 oxidoreductase; Provisional; Region: PRK08017 481805010099 17beta hydroxysteroid dehydrogenase-like, classical (c) SDRs; Region: 17beta-HSD-like_SDR_c; cd05374 481805010100 NADP binding site [chemical binding]; other site 481805010101 active site 481805010102 steroid binding site; other site 481805010103 Thioredoxin domain-containing protein [Posttranslational modification, protein turnover, chaperones]; Region: COG3118 481805010104 ybbN protein family; ybbN is a hypothetical protein containing a redox-inactive TRX-like domain. Its gene has been sequenced from several gammaproteobacteria and actinobacteria; Region: ybbN; cd02956 481805010105 Uncharacterized protein family (UPF0014); Region: UPF0014; pfam03649 481805010106 putative ABC transporter ATP-binding protein YbbL; Provisional; Region: PRK10247 481805010107 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805010108 Walker A/P-loop; other site 481805010109 ATP binding site [chemical binding]; other site 481805010110 Q-loop/lid; other site 481805010111 ABC transporter signature motif; other site 481805010112 Walker B; other site 481805010113 D-loop; other site 481805010114 H-loop/switch region; other site 481805010115 Membrane protease subunits, stomatin/prohibitin homologs [Posttranslational modification, protein turnover, chaperones]; Region: HflC; COG0330 481805010116 Band_7_stomatin_like: A subgroup of the band 7 domain of flotillin (reggie) like proteins similar to stomatin and podicin (two lipid raft-associated integral membrane proteins). Individual proteins of this band 7 domain family may cluster to form...; Region: Band_7_stomatin_like; cd03403 481805010117 Membrane protein implicated in regulation of membrane protease activity [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: COG1585 481805010118 DNA-binding transcriptional regulator CueR; Provisional; Region: PRK10227 481805010119 Helix-Turn-Helix DNA binding domain of CueR-like transcription regulators; Region: HTH_CueR; cd01108 481805010120 DNA binding residues [nucleotide binding] 481805010121 dimer interface [polypeptide binding]; other site 481805010122 copper binding site [ion binding]; other site 481805010123 amino acid transporter; Region: 2A0306; TIGR00909 481805010124 glutaminase; Reviewed; Region: PRK12356 481805010125 Glutaminase [Amino acid transport and metabolism]; Region: GlsA; COG2066 481805010126 copper exporting ATPase; Provisional; Region: copA; PRK10671 481805010127 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 481805010128 metal-binding site [ion binding] 481805010129 Heavy-metal-associated domain (HMA) is a conserved domain of approximately 30 amino acid residues found in a number of proteins that transport or detoxify heavy metals, for example, the CPx-type heavy metal ATPases and copper chaperones. HMA domain...; Region: HMA; cd00371 481805010130 metal-binding site [ion binding] 481805010131 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 481805010132 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805010133 motif II; other site 481805010134 Plasmid maintenance system antidote protein [General function prediction only]; Region: VapI; COG3093 481805010135 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805010136 non-specific DNA binding site [nucleotide binding]; other site 481805010137 salt bridge; other site 481805010138 sequence-specific DNA binding site [nucleotide binding]; other site 481805010139 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3735 481805010140 This CD includes cysteinyl-tRNA(Pro) deacylases from Haemophilus influenzae and Escherichia coli and other related bacterial proteins. These trans-acting, single-domain proteins are homologs of ProX and also the cis-acting prolyl-tRNA synthetase (ProRS)...; Region: YbaK_deacylase; cd00002 481805010141 putative deacylase active site [active] 481805010142 bifunctional UDP-sugar hydrolase/5'-nucleotidase periplasmic precursor; Reviewed; Region: ushA; PRK09558 481805010143 Escherichia coli UshA and related proteins, N-terminal metallophosphatase domain; Region: MPP_UshA_N; cd07405 481805010144 active site 481805010145 metal binding site [ion binding]; metal-binding site 481805010146 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 481805010147 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805010148 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481805010149 putative substrate translocation pore; other site 481805010150 putative cation:proton antiport protein; Provisional; Region: PRK10669 481805010151 Kef-type K+ transport system, predicted NAD-binding component [Inorganic ion transport and metabolism]; Region: RosB; COG4651 481805010152 TrkA-N domain; Region: TrkA_N; pfam02254 481805010153 inosine/guanosine kinase; Provisional; Region: PRK15074 481805010154 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 481805010155 acetyl esterase; Provisional; Region: PRK10162 481805010156 ferrochelatase; Region: hemH; TIGR00109 481805010157 Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_N; cd03411 481805010158 C-terminal domain interface [polypeptide binding]; other site 481805010159 active site 481805010160 Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme biosynthetic pathway. It catalyzes the insertion of ferrous iron into the protoporphyrin IX ring yielding protoheme. This enzyme is...; Region: Ferrochelatase_C; cd00419 481805010161 active site 481805010162 N-terminal domain interface [polypeptide binding]; other site 481805010163 adenylate kinase; Reviewed; Region: adk; PRK00279 481805010164 Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine monophosphates (AMP) and to yield adenosine diphosphates (ADP). This enzyme is required for the biosynthesis of ADP and is essential for...; Region: ADK; cd01428 481805010165 AMP-binding site [chemical binding]; other site 481805010166 ATP-AMP (Ap5A)-binding site [chemical binding]; other site 481805010167 heat shock protein 90; Provisional; Region: PRK05218 481805010168 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805010169 ATP binding site [chemical binding]; other site 481805010170 Mg2+ binding site [ion binding]; other site 481805010171 G-X-G motif; other site 481805010172 Recombinational DNA repair protein (RecF pathway) [DNA replication, recombination, and repair]; Region: RecR; COG0353 481805010173 RecR protein; Region: RecR; pfam02132 481805010174 TOPRIM_recR: topoisomerase-primase (TOPRIM) nucleotidyl transferase/hydrolase domain of the type found in Escherichia coli RecR. RecR participates in the RecFOR pathway of homologous recombinational repair in prokaryotes. This pathway provides a...; Region: TOPRIM_recR; cd01025 481805010175 putative active site [active] 481805010176 putative metal-binding site [ion binding]; other site 481805010177 tetramer interface [polypeptide binding]; other site 481805010178 hypothetical protein; Validated; Region: PRK00153 481805010179 DNA polymerase III subunits gamma and tau; Validated; Region: PRK07994 481805010180 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805010181 Walker A motif; other site 481805010182 ATP binding site [chemical binding]; other site 481805010183 Walker B motif; other site 481805010184 DNA polymerase III subunit delta'; Validated; Region: PRK08485 481805010185 arginine finger; other site 481805010186 DNA polymerase III subunits gamma and tau domain III; Region: DNA_pol3_gamma3; pfam12169 481805010187 DNA polymerase III subunits tau domain IV DnaB-binding; Region: DNA_pol3_tau_4; pfam12168 481805010188 DNA polymerase III tau subunit V interacting with alpha; Region: DNA_pol3_tau_5; pfam12170 481805010189 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481805010190 active site 481805010191 hypothetical protein; Provisional; Region: PRK10527 481805010192 primosomal replication protein N''; Provisional; Region: PRK10093 481805010193 hypothetical protein; Provisional; Region: PRK11038 481805010194 hypothetical protein; Provisional; Region: PRK11281 481805010195 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 481805010196 Transmembrane subunit (TM) of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which are involved in the uptake of branched-chain amino acids (AAs), as well as TMs of transporters involved in the uptake of...; Region: TM_PBP1_branched-chain-AA_like; cl00454 481805010197 Mechanosensitive ion channel; Region: MS_channel; pfam00924 481805010198 DNA-binding transcriptional repressor AcrR; Provisional; Region: PRK10668 481805010199 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481805010200 MAATS-type transcriptional repressor, C-terminal region; Region: TetR_C_2; pfam08361 481805010201 multidrug efflux system transporter AcrA; Provisional; Region: PRK15030 481805010202 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481805010203 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805010204 multidrug efflux system protein AcrB; Provisional; Region: PRK15127 481805010205 Protein export membrane protein; Region: SecD_SecF; cl14618 481805010206 Protein export membrane protein; Region: SecD_SecF; cl14618 481805010207 Biofilm formation regulator YbaJ; Region: YbaJ; pfam10757 481805010208 gene expression modulator; Provisional; Region: PRK10945 481805010209 maltose O-acetyltransferase; Provisional; Region: PRK10092 481805010210 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 481805010211 active site 481805010212 substrate binding site [chemical binding]; other site 481805010213 trimer interface [polypeptide binding]; other site 481805010214 CoA binding site [chemical binding]; other site 481805010215 sigma70 family sigma factor YlaC; Region: YlaC; pfam10777 481805010216 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 481805010217 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 481805010218 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805010219 Uncharacterized conserved protein [Function unknown]; Region: COG5507 481805010220 Methylated DNA-protein cysteine methyltransferase [DNA replication, recombination, and repair]; Region: Ada; COG0350 481805010221 The DNA repair protein O6-alkylguanine-DNA alkyltransferase (ATase; also known as AGT, AGAT and MGMT) reverses O6-alkylation DNA damage by transferring O6-alkyl adducts to an active site cysteine irreversibly, without inducing DNA strand breaks. ATases...; Region: ATase; cd06445 481805010222 DNA binding site [nucleotide binding] 481805010223 active site 481805010224 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3126 481805010225 acyl-CoA thioesterase II; Provisional; Region: PRK10526 481805010226 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat2; cd03445 481805010227 active site 481805010228 Thioesterase II (TEII) is thought to regenerate misprimed nonribosomal peptide synthetases (NRPSs) as well as modular polyketide synthases (PKSs) by hydrolyzing acetyl groups bound to the peptidyl carrier protein (PCP) and acyl carrier protein (ACP)...; Region: Thioesterase_II_repeat1; cd03444 481805010229 catalytic triad [active] 481805010230 dimer interface [polypeptide binding]; other site 481805010231 ammonium transporter; Provisional; Region: PRK10666 481805010232 nitrogen regulatory protein P-II 2; Provisional; Region: PRK10665 481805010233 Nitrogen regulatory protein P-II; Region: P-II; smart00938 481805010234 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10790 481805010235 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481805010236 ATP-binding cassette domain of glucan transporter and related proteins, subfamily C; Region: ABCC_Glucan_exporter_like; cd03254 481805010237 Walker A/P-loop; other site 481805010238 ATP binding site [chemical binding]; other site 481805010239 Q-loop/lid; other site 481805010240 ABC transporter signature motif; other site 481805010241 Walker B; other site 481805010242 D-loop; other site 481805010243 H-loop/switch region; other site 481805010244 ABC transporter transmembrane region; Region: ABC_membrane; pfam00664 481805010245 putative multidrug transporter membrane\ATP-binding components; Provisional; Region: PRK10789 481805010246 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805010247 Walker A/P-loop; other site 481805010248 ATP binding site [chemical binding]; other site 481805010249 Q-loop/lid; other site 481805010250 ABC transporter signature motif; other site 481805010251 Walker B; other site 481805010252 D-loop; other site 481805010253 H-loop/switch region; other site 481805010254 Transcriptional regulators [Transcription]; Region: Lrp; COG1522 481805010255 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481805010256 putative DNA binding site [nucleotide binding]; other site 481805010257 putative Zn2+ binding site [ion binding]; other site 481805010258 AsnC family; Region: AsnC_trans_reg; pfam01037 481805010259 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805010260 thiamin pyrimidine pyrophosphate hydrolase; Provisional; Region: PRK15126 481805010261 motif II; other site 481805010262 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805010263 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805010264 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805010265 IS1 transposase; Region: DDE_Tnp_IS1; pfam03400 481805010266 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805010267 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805010268 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805010269 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805010270 Undecaprenyl-phosphate glucose phosphotransferase; Region: WcaJ_sugtrans; TIGR03023 481805010271 Bacterial sugar transferase; Region: Bac_transf; pfam02397 481805010272 Uncharacterized protein conserved in bacteria (DUF2320); Region: DUF2320; pfam10082 481805010273 Polysaccharide biosynthesis/export protein; Region: Poly_export; pfam02563 481805010274 putative polysaccharide export protein, PEP-CTERM sytem-associated; Region: pepcterm_export; TIGR03027 481805010275 SLBB domain; Region: SLBB; pfam10531 481805010276 Uncharacterized protein involved in exopolysaccharide biosynthesis [Cell envelope biogenesis, outer membrane]; Region: GumC; COG3206 481805010277 Chain length determinant protein; Region: Wzz; pfam02706 481805010278 capsular exopolysaccharide family; Region: eps_fam; TIGR01007 481805010279 Polysaccharide biosynthesis protein; Region: Polysacc_synt_3; pfam13440 481805010280 Multidrug and toxic compound extrusion family and similar proteins; Region: MATE_like; cl09326 481805010281 Glycosyltransferase like family 2; Region: Glyco_tranf_2_3; pfam13641 481805010282 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cl11394 481805010283 active site 481805010284 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 481805010285 This family is most closely related to the GT1 family of glycosyltransferases and named after YqgM in Bacillus licheniformis about which little is known. Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to...; Region: GT1_YqgM_like; cd03801 481805010286 Glycosyltransferases catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds. The acceptor molecule can be a lipid, a protein, a heterocyclic compound, or another carbohydrate...; Region: Glycosyltransferase_GTB_type; cl10013 481805010287 Glycosyltransferase [Cell envelope biogenesis, outer membrane]; Region: RfaG; COG0438 481805010288 Beta-galactosidase; Region: Glyco_hydro_42; pfam02449 481805010289 UDP-glucose 4-epimerase; Region: PLN02240 481805010290 UDP-glucose 4 epimerase, subgroup 1, extended (e) SDRs; Region: UDP_G4E_1_SDR_e; cd05247 481805010291 NAD binding site [chemical binding]; other site 481805010292 homodimer interface [polypeptide binding]; other site 481805010293 active site 481805010294 substrate binding site [chemical binding]; other site 481805010295 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805010296 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805010297 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805010298 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805010299 ABC-type uncharacterized transport system, periplasmic component [General function prediction only]; Region: COG4533 481805010300 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 481805010301 The substrate-binding domain of an ABC-type nickel/oligopeptide-like import system contains the type 2 periplasmic binding fold; Region: PBP2_NikA_DppA_OppA_like; cl01709 481805010302 ExsB is a transcription regulator related protein. It is a subfamily of a Adenosine nucleotide binding superfamily of proteins. This protein family is represented by a single member in nearly every completed large (> 1000 genes) prokaryotic genome. In...; Region: ExsB; cd01995 481805010303 Ligand Binding Site [chemical binding]; other site 481805010304 4-hydroxybenzoyl-CoA thioesterase (4HBT). Catalyzes the final step in the 4-chlorobenzoate degradation pathway in which 4-chlorobenzoate is converted to 4-hydroxybenzoate in certain soil-dwelling bacteria. 4HBT forms a homotetramer with four active sites; Region: 4HBT; cd00586 481805010305 active site 481805010306 competence protein ComEA helix-hairpin-helix repeat region; Region: TIGR00426 481805010307 periplasmic folding chaperone; Provisional; Region: PRK10788 481805010308 SurA N-terminal domain; Region: SurA_N_3; cl07813 481805010309 PPIC-type PPIASE domain; Region: Rotamase_2; pfam13145 481805010310 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 481805010311 IHF dimer interface [polypeptide binding]; other site 481805010312 IHF - DNA interface [nucleotide binding]; other site 481805010313 DNA-binding ATP-dependent protease La; Provisional; Region: PRK10787 481805010314 Found in ATP-dependent protease La (LON); Region: LON; smart00464 481805010315 Found in ATP-dependent protease La (LON); Region: LON; smart00464 481805010316 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805010317 Walker A motif; other site 481805010318 ATP binding site [chemical binding]; other site 481805010319 Walker B motif; other site 481805010320 arginine finger; other site 481805010321 Lon protease (S16) C-terminal proteolytic domain; Region: Lon_C; pfam05362 481805010322 ATP-dependent protease ATP-binding subunit ClpX; Provisional; Region: clpX; PRK05342 481805010323 ClpX C4-type zinc finger; Region: zf-C4_ClpX; pfam06689 481805010324 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805010325 Walker A motif; other site 481805010326 ATP binding site [chemical binding]; other site 481805010327 Walker B motif; other site 481805010328 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 481805010329 Protease subunit of ATP-dependent Clp proteases [Posttranslational modification, protein turnover, chaperones / Intracellular trafficking and secretion]; Region: ClpP; COG0740 481805010330 Caseinolytic protease (ClpP) is an ATP-dependent, highly conserved serine protease; Region: S14_ClpP_2; cd07017 481805010331 oligomer interface [polypeptide binding]; other site 481805010332 active site residues [active] 481805010333 trigger factor; Provisional; Region: tig; PRK01490 481805010334 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 481805010335 Bacterial trigger factor protein (TF) C-terminus; Region: Trigger_C; pfam05698 481805010336 transcriptional regulator BolA; Provisional; Region: PRK11628 481805010337 hypothetical protein; Provisional; Region: PRK11627 481805010338 Uncharacterized lipoprotein; Region: Lipoprotein_16; pfam03923 481805010339 muropeptide transporter; Reviewed; Region: ampG; PRK11902 481805010340 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805010341 putative substrate translocation pore; other site 481805010342 cytochrome o ubiquinol oxidase subunit II; Provisional; Region: PRK10525 481805010343 Cytochrome C oxidase subunit II, periplasmic domain; Region: COX2; pfam00116 481805010344 COX Aromatic Rich Motif; Region: COX_ARM; pfam06481 481805010345 Heme/copper-type cytochrome/quinol oxidases, subunit 1 [Energy production and conversion]; Region: CyoB; COG0843 481805010346 Ubiquinol oxidase subunit I. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously pumps protons...; Region: Ubiquinol_Oxidase_I; cd01662 481805010347 D-pathway; other site 481805010348 Putative ubiquinol binding site [chemical binding]; other site 481805010349 Low-spin heme (heme b) binding site [chemical binding]; other site 481805010350 Putative water exit pathway; other site 481805010351 Binuclear center (heme o3/CuB) [ion binding]; other site 481805010352 K-pathway; other site 481805010353 Putative proton exit pathway; other site 481805010354 Ubiquinol oxidase subunit III subfamily. Ubiquinol oxidase, the terminal oxidase in the respiratory chains of aerobic bacteria, is a multi-chain transmembrane protein located in the cell membrane. It catalyzes the reduction of O2 and simultaneously...; Region: Ubiquinol_oxidase_III; cd02863 481805010355 Subunit I/III interface [polypeptide binding]; other site 481805010356 Subunit III/IV interface [polypeptide binding]; other site 481805010357 cytochrome o ubiquinol oxidase subunit IV; Provisional; Region: PRK10582 481805010358 protoheme IX farnesyltransferase; Provisional; Region: PRK13362 481805010359 UbiA prenyltransferase family; Region: UbiA; pfam01040 481805010360 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805010361 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481805010362 putative substrate translocation pore; other site 481805010363 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG1666 481805010364 Proteins similar to Escherichia coli YajQ; Region: YajQ_like; cd11740 481805010365 2-dehydropantoate 2-reductase; Reviewed; Region: PRK06522 481805010366 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 481805010367 Ketopantoate reductase PanE/ApbA C terminal; Region: ApbA_C; pfam08546 481805010368 oxidative-stress-resistance chaperone; Provisional; Region: PRK11574 481805010369 Type 1 glutamine amidotransferase (GATase1)-like domain found in Human DJ-1; Region: GATase1_DJ-1; cd03135 481805010370 conserved cys residue [active] 481805010371 tRNA s(4)U8 sulfurtransferase; Provisional; Region: PRK01269 481805010372 THUMP domain of thiamine biosynthesis protein ThiI; Region: THUMP_ThiI; cd11716 481805010373 ThiI is required for thiazole synthesis in the thiamine biosynthesis pathway. It belongs to the Adenosine Nucleotide Hydrolysis suoerfamily and predicted to bind to Adenosine nucleotide; Region: ThiI; cd01712 481805010374 Ligand Binding Site [chemical binding]; other site 481805010375 Rhodanese Homology Domain (RHOD); an alpha beta fold domain found duplicated in the rhodanese protein. The cysteine containing enzymatically active version of the domain is also found in the Cdc25 class of protein phosphatases and a variety of proteins...; Region: RHOD; cd00158 481805010376 active site residue [active] 481805010377 exodeoxyribonuclease VII small subunit; Provisional; Region: PRK00977 481805010378 Geranylgeranyl pyrophosphate synthase [Coenzyme metabolism]; Region: IspA; COG0142 481805010379 Trans-Isoprenyl Diphosphate Synthases, head-to-tail; Region: Trans_IPPS_HT; cd00685 481805010380 substrate binding pocket [chemical binding]; other site 481805010381 chain length determination region; other site 481805010382 substrate-Mg2+ binding site; other site 481805010383 catalytic residues [active] 481805010384 aspartate-rich region 1; other site 481805010385 active site lid residues [active] 481805010386 aspartate-rich region 2; other site 481805010387 1-deoxy-D-xylulose-5-phosphate synthase; Region: dxs; TIGR00204 481805010388 Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is a regulatory enzyme of the mevalonate-independent pathway involved in terpenoid biosynthesis. Terpeniods are plant natural products...; Region: TPP_DXS; cd02007 481805010389 TPP-binding site; other site 481805010390 Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related proteins; Region: TPP_PYR_DXS_TK_like; cd07033 481805010391 PYR/PP interface [polypeptide binding]; other site 481805010392 dimer interface [polypeptide binding]; other site 481805010393 TPP binding site [chemical binding]; other site 481805010394 Transketolase, C-terminal domain; Region: Transketolase_C; pfam02780 481805010395 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481805010396 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481805010397 active site 481805010398 catalytic tetrad [active] 481805010399 Phosphatidylglycerophosphatase A; a bacterial membrane-associated enzyme involved in lipid metabolism; Region: PgpA; cd06971 481805010400 tetramer interfaces [polypeptide binding]; other site 481805010401 binuclear metal-binding site [ion binding]; other site 481805010402 thiamine monophosphate kinase; Provisional; Region: PRK05731 481805010403 ThiL (Thiamine-monophosphate kinase) plays a dual role in de novo biosynthesis and in salvage of exogenous thiamine. Thiamine salvage occurs in two steps, with thiamine kinase catalyzing the formation of thiamine phosphate, and ThiL catalyzing the...; Region: ThiL; cd02194 481805010404 ATP binding site [chemical binding]; other site 481805010405 dimerization interface [polypeptide binding]; other site 481805010406 Transcription termination factor NusB (N protein-Utilization Substance B). NusB plays a key role in the regulation of ribosomal RNA biosynthesis in eubacteria by modulating the efficiency of transcriptional antitermination. NusB along with other Nus...; Region: Terminator_NusB; cd00619 481805010407 putative RNA binding site [nucleotide binding]; other site 481805010408 lumazine synthase (6,7-dimethyl-8-ribityllumazine synthase, LS), catalyzes the penultimate step in the biosynthesis of riboflavin (vitamin B2); type-I; Region: Lumazine_synthase-I; cd09209 481805010409 homopentamer interface [polypeptide binding]; other site 481805010410 active site 481805010411 bifunctional diaminohydroxyphosphoribosylaminopyrimidine deaminase/5-amino-6-(5-phosphoribosylamino)uracil reductase; Provisional; Region: ribD; PRK10786 481805010412 Riboflavin-specific deaminase. Riboflavin biosynthesis protein RibD (Diaminohydroxyphosphoribosylaminopyrimidine deaminase) catalyzes the deamination of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, which is an intermediate step in the...; Region: Riboflavin_deaminase-reductase; cd01284 481805010413 catalytic motif [active] 481805010414 Zn binding site [ion binding]; other site 481805010415 riboflavin-specific deaminase C-terminal domain; Region: ribD_Cterm; TIGR00227 481805010416 transcriptional regulator NrdR; Validated; Region: nrdR; PRK00464 481805010417 ATP cone domain; Region: ATP-cone; pfam03477 481805010418 hypothetical protein; Provisional; Region: PRK11530 481805010419 nucleoside-specific channel-forming protein Tsx; Provisional; Region: PRK15106 481805010420 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 481805010421 active site 481805010422 preprotein translocase subunit SecF; Reviewed; Region: secF; PRK13022 481805010423 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 481805010424 Protein export membrane protein; Region: SecD_SecF; pfam02355 481805010425 SecD export protein N-terminal TM region; Region: SecD-TM1; pfam13721 481805010426 preprotein translocase subunit SecD; Reviewed; Region: secD; PRK05812 481805010427 SecD/SecF GG Motif; Region: Sec_GG; pfam07549 481805010428 protein-export membrane protein, SecD/SecF family; Region: 2A0604s01; TIGR00916 481805010429 preprotein translocase subunit YajC; Validated; Region: yajC; PRK05585 481805010430 queuine tRNA-ribosyltransferase; Provisional; Region: tgt; PRK00112 481805010431 tRNA-guanine family transglycosylase; Region: tgt_general; TIGR00449 481805010432 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Provisional; Region: queA; PRK00147 481805010433 S-adenosylmethionine:tRNA ribosyltransferase-isomerase; Region: queA; TIGR00113 481805010434 acyl carrier protein phosphodiesterase; Provisional; Region: PRK10045 481805010435 maltodextrin glucosidase; Provisional; Region: PRK10785 481805010436 N-terminal Early set domain associated with the catalytic domain of cyclomaltodextrinase and pullulan-degrading enzymes; Region: E_set_CDase_PDE_N; cd02857 481805010437 homodimer interface [polypeptide binding]; other site 481805010438 Alpha amylase catalytic domain found in cyclomaltodextrinases and related proteins; Region: AmyAc_CMD; cd11338 481805010439 active site 481805010440 homodimer interface [polypeptide binding]; other site 481805010441 catalytic site [active] 481805010442 putative proline-specific permease; Provisional; Region: proY; PRK10580 481805010443 Spore germination protein; Region: Spore_permease; cl17796 481805010444 branched-chain amino acid transport system 2 carrier protein BrnQ; Provisional; Region: PRK15433 481805010445 phosphate regulon sensor protein; Provisional; Region: phoR; PRK11006 481805010446 Domain of unknown function (DUF3329); Region: DUF3329; pfam11808 481805010447 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481805010448 putative active site [active] 481805010449 heme pocket [chemical binding]; other site 481805010450 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805010451 dimer interface [polypeptide binding]; other site 481805010452 phosphorylation site [posttranslational modification] 481805010453 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805010454 ATP binding site [chemical binding]; other site 481805010455 Mg2+ binding site [ion binding]; other site 481805010456 G-X-G motif; other site 481805010457 transcriptional regulator PhoB; Provisional; Region: PRK10161 481805010458 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805010459 active site 481805010460 phosphorylation site [posttranslational modification] 481805010461 intermolecular recognition site; other site 481805010462 dimerization interface [polypeptide binding]; other site 481805010463 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805010464 DNA binding site [nucleotide binding] 481805010465 exonuclease subunit SbcD; Provisional; Region: PRK10966 481805010466 Mre11 nuclease, N-terminal metallophosphatase domain; Region: MPP_Mre11_N; cd00840 481805010467 active site 481805010468 metal binding site [ion binding]; metal-binding site 481805010469 DNA binding site [nucleotide binding] 481805010470 Type 5 capsule protein repressor C-terminal domain; Region: SbcD_C; pfam12320 481805010471 exonuclease subunit SbcC; Provisional; Region: PRK10246 481805010472 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805010473 Walker A/P-loop; other site 481805010474 ATP binding site [chemical binding]; other site 481805010475 Q-loop/lid; other site 481805010476 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805010477 ABC transporter signature motif; other site 481805010478 Walker B; other site 481805010479 D-loop; other site 481805010480 H-loop/switch region; other site 481805010481 MFS transport protein AraJ; Provisional; Region: PRK10091 481805010482 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805010483 putative substrate translocation pore; other site 481805010484 fructokinase; Reviewed; Region: PRK09557 481805010485 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481805010486 nucleotide binding site [chemical binding]; other site 481805010487 DNA recombination-dependent growth factor C [DNA replication, recombination, and repair]; Region: RdgC; COG2974 481805010488 Protein of unknown function (DUF2773); Region: DUF2773; pfam10971 481805010489 hypothetical protein; Provisional; Region: PRK10579 481805010490 hypothetical protein; Provisional; Region: PRK10481 481805010491 hypothetical protein; Provisional; Region: PRK10380 481805010492 Shikimate kinase [Amino acid transport and metabolism]; Region: AroK; COG0703 481805010493 Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts erythrose-4-phosphate to chorismic acid, found in bacteria, fungi and plants. Chorismic acid is a important intermediate in the synthesis...; Region: SK; cd00464 481805010494 ADP binding site [chemical binding]; other site 481805010495 magnesium binding site [ion binding]; other site 481805010496 putative shikimate binding site; other site 481805010497 hypothetical protein; Validated; Region: PRK00124 481805010498 pyrroline-5-carboxylate reductase; Reviewed; Region: PRK11880 481805010499 pyrroline-5-carboxylate reductase; Region: PLN02688 481805010500 diguanylate cyclase AdrA; Provisional; Region: adrA; PRK10245 481805010501 MASE2 domain; Region: MASE2; pfam05230 481805010502 Diguanylate-cyclase (DGC) or GGDEF domain; Region: GGDEF; cd01949 481805010503 metal binding site [ion binding]; metal-binding site 481805010504 active site 481805010505 I-site; other site 481805010506 hypothetical protein; Provisional; Region: PRK11505 481805010507 psiF repeat; Region: PsiF_repeat; pfam07769 481805010508 psiF repeat; Region: PsiF_repeat; pfam07769 481805010509 alkaline phosphatase; Provisional; Region: PRK10518 481805010510 Alkaline phosphatase homologues; alkaline phosphatases are non-specific phosphomonoesterases that catalyze the hydrolysis reaction via a phosphoseryl intermediate to produce inorganic phosphate and the corresponding alcohol, optimally at high pH; Region: alkPPc; cd00016 481805010511 dimer interface [polypeptide binding]; other site 481805010512 active site 481805010513 anti-RssB factor; Provisional; Region: PRK10244 481805010514 D-alanyl-alanine synthetase A; Reviewed; Region: ddl; PRK01966 481805010515 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 481805010516 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 481805010517 Protein of unknown function (DUF2754); Region: DUF2754; pfam10953 481805010518 Protein of unknown function (DUF2755); Region: DUF2755; pfam10954 481805010519 Protein of unknown function (DUF1615); Region: DUF1615; pfam07759 481805010520 microcin B17 transporter; Reviewed; Region: PRK11098 481805010521 beta-lactam binding protein AmpH; Provisional; Region: PRK10662 481805010522 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 481805010523 putative DNA-binding transcriptional regulator; Provisional; Region: PRK11832 481805010524 outer membrane autotransporter barrel domain; Region: autotrans_barl; TIGR01414 481805010525 Pertactin-like passenger domains (virulence factors) of autotransporter proteins of the type V secretion system. Autotransporters are proteins used by Gram-negative bacteria to transport proteins across their outer membranes. The C-terminal (beta) domain...; Region: PL_Passenger_AT; cd00253 481805010526 Autotransporter beta-domain; Region: Autotransporter; pfam03797 481805010527 Porphobilinogen synthase (PBGS), which is also called delta-aminolevulinic acid dehydratase (ALAD), catalyzes the condensation of two 5-aminolevulinic acid (ALA) molecules to form the pyrrole porphobilinogen (PBG), which is the second step in the...; Region: ALAD_PBGS; cd00384 481805010528 dimer interface [polypeptide binding]; other site 481805010529 active site 481805010530 Schiff base residues; other site 481805010531 Probable taurine catabolism dioxygenase [Secondary metabolites biosynthesis, transport, and catabolism]; Region: TauD; COG2175 481805010532 taurine dioxygenase; Reviewed; Region: tauD; PRK09553 481805010533 ABC-type nitrate/sulfonate/bicarbonate transport system, permease component [Inorganic ion transport and metabolism]; Region: TauC; COG0600 481805010534 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805010535 dimer interface [polypeptide binding]; other site 481805010536 conserved gate region; other site 481805010537 putative PBP binding loops; other site 481805010538 ABC-ATPase subunit interface; other site 481805010539 taurine transporter ATP-binding subunit; Provisional; Region: tauB; PRK11248 481805010540 ATP-binding cassette domain of the nitrate and sulfonate transporters; Region: ABC_NrtD_SsuB_transporters; cd03293 481805010541 Walker A/P-loop; other site 481805010542 ATP binding site [chemical binding]; other site 481805010543 Q-loop/lid; other site 481805010544 ABC transporter signature motif; other site 481805010545 Walker B; other site 481805010546 D-loop; other site 481805010547 H-loop/switch region; other site 481805010548 ABC-type taurine transport system, periplasmic component [Inorganic ion transport and metabolism]; Region: TauA; COG4521 481805010549 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805010550 substrate binding pocket [chemical binding]; other site 481805010551 membrane-bound complex binding site; other site 481805010552 hinge residues; other site 481805010553 Uncharacterized proteins, LmbE homologs [Function unknown]; Region: COG2120 481805010554 Glycosyltransferases, probably involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: COG1215 481805010555 CESA_like is the cellulose synthase superfamily; Region: CESA_like; cd06423 481805010556 DXD motif; other site 481805010557 Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes...; Region: LbetaH; cl00160 481805010558 putative trimer interface [polypeptide binding]; other site 481805010559 putative CoA binding site [chemical binding]; other site 481805010560 Transcriptional regulators RcnR and FrmR, and related domains; this domain family was previously known as part of DUF156; Region: RcnR-FrmR-like_DUF156; cd10153 481805010561 putative metal binding site [ion binding]; other site 481805010562 putative homodimer interface [polypeptide binding]; other site 481805010563 putative homotetramer interface [polypeptide binding]; other site 481805010564 putative homodimer-homodimer interface [polypeptide binding]; other site 481805010565 putative allosteric switch controlling residues; other site 481805010566 class III alcohol dehydrogenases; Region: alcohol_DH_class_III; cd08300 481805010567 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase; Region: adh_III_F_hyde; TIGR02818 481805010568 substrate binding site [chemical binding]; other site 481805010569 catalytic Zn binding site [ion binding]; other site 481805010570 NAD binding site [chemical binding]; other site 481805010571 structural Zn binding site [ion binding]; other site 481805010572 dimer interface [polypeptide binding]; other site 481805010573 S-formylglutathione hydrolase; Region: fghA_ester_D; TIGR02821 481805010574 S-formylglutathione hydrolase; Region: PLN02442 481805010575 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3122 481805010576 putative 3-hydroxyphenylpropionic transporter MhpT; Provisional; Region: PRK11551 481805010577 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805010578 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805010579 4-hyroxy-2-oxovalerate/4-hydroxy-2-oxopentanoic acid aldolase,; Validated; Region: PRK08195 481805010580 4-hydroxy-2-oxovalerate aldolase, N-terminal catalytic TIM barrel domain; Region: DRE_TIM_HOA; cd07943 481805010581 active site 481805010582 catalytic residues [active] 481805010583 metal binding site [ion binding]; metal-binding site 481805010584 DmpG-like communication domain; Region: DmpG_comm; pfam07836 481805010585 acetaldehyde dehydrogenase; Validated; Region: PRK08300 481805010586 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 481805010587 Prokaryotic acetaldehyde dehydrogenase, dimerisation; Region: AcetDehyd-dimer; pfam09290 481805010588 2-keto-4-pentenoate hydratase; Provisional; Region: mhpD; PRK11342 481805010589 2-hydroxy-6-oxo-6-phenylhexa-2,4-dienoate hydrolase; Region: biphenyl_bphD; TIGR03343 481805010590 Subunit B of the Class III Extradiol ring-cleavage dioxygenase, 2,3-dihydroxyphenylpropionate 1,2-dioxygenase (MhpB), which catalyzes the oxidization and subsequent ring-opening of 2,3-dihydroxyphenylpropionate; Region: MhpB_like; cd07365 481805010591 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 481805010592 putative active site [active] 481805010593 Fe(II) binding site [ion binding]; other site 481805010594 putative dimer interface [polypeptide binding]; other site 481805010595 putative tetramer interface [polypeptide binding]; other site 481805010596 3-(3-hydroxyphenyl)propionate hydroxylase; Validated; Region: mhpA; PRK06183 481805010597 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 481805010598 DNA-binding transcriptional activator MhpR; Provisional; Region: PRK09834 481805010599 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 481805010600 Bacterial transcriptional regulator; Region: IclR; pfam01614 481805010601 lac repressor; Reviewed; Region: lacI; PRK09526 481805010602 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481805010603 DNA binding site [nucleotide binding] 481805010604 domain linker motif; other site 481805010605 Ligand-binding domain of DNA transcription repressor LacI specific for lactose, a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_LacI; cd01574 481805010606 ligand binding site [chemical binding]; other site 481805010607 dimerization interface (open form) [polypeptide binding]; other site 481805010608 dimerization interface (closed form) [polypeptide binding]; other site 481805010609 beta-D-galactosidase; Reviewed; Region: lacZ; PRK09525 481805010610 Glycosyl hydrolases family 2, sugar binding domain; Region: Glyco_hydro_2_N; pfam02837 481805010611 Glycosyl hydrolases family 2; Region: Glyco_hydro_2; pfam00703 481805010612 Glycosyl hydrolases family 2, TIM barrel domain; Region: Glyco_hydro_2_C; pfam02836 481805010613 Beta galactosidase small chain; Region: Bgal_small_N; pfam02929 481805010614 LacY proton/sugar symporter; Region: LacY_symp; pfam01306 481805010615 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805010616 putative substrate translocation pore; other site 481805010617 galactoside O-acetyltransferase; Reviewed; Region: lacA; PRK09527 481805010618 Maltose O-acetyltransferase (MAT) and Galactoside O-acetyltransferase (GAT): MAT and GAT catalyze the CoA-dependent acetylation of the 6-hydroxyl group of their respective sugar substrates. MAT acetylates maltose and glucose exclusively at the C6...; Region: LbH_MAT_GAT; cd03357 481805010619 active site 481805010620 substrate binding site [chemical binding]; other site 481805010621 trimer interface [polypeptide binding]; other site 481805010622 CoA binding site [chemical binding]; other site 481805010623 putative cyanate transporter; Provisional; Region: cynX; PRK09705 481805010624 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805010625 Cyanate lyase [Inorganic ion transport and metabolism]; Region: CynS; COG1513 481805010626 Cyanase C-terminal domain. Cyanase (Cyanate lyase) is responsible for the hydrolysis of cyanate. It catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. This allows organisms that possess the enzyme to overcome the...; Region: Cyanase_C; cd00559 481805010627 oligomer interface [polypeptide binding]; other site 481805010628 active site 481805010629 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeB; cd00884 481805010630 active site clefts [active] 481805010631 zinc binding site [ion binding]; other site 481805010632 dimer interface [polypeptide binding]; other site 481805010633 DNA-binding transcriptional regulator CynR; Provisional; Region: PRK11242 481805010634 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805010635 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator CynR, contains the type 2 periplasmic binding fold; Region: PBP2_CynR; cd08425 481805010636 dimerization interface [polypeptide binding]; other site 481805010637 cytosine deaminase; Provisional; Region: PRK09230 481805010638 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 481805010639 active site 481805010640 nucleobase-cation-symport-1 (NCS1) transporter CobB-like; solute-binding domain; Region: SLC-NCS1sbd_CobB-like; cd11484 481805010641 Permease for cytosine/purines, uracil, thiamine, allantoin; Region: Transp_cyt_pur; pfam02133 481805010642 Na binding site [ion binding]; other site 481805010643 putative substrate binding site [chemical binding]; other site 481805010644 propionyl-CoA synthetase; Provisional; Region: prpE; PRK10524 481805010645 Propionyl-CoA synthetase (PrpE); Region: PrpE; cd05967 481805010646 acyl-activating enzyme (AAE) consensus motif; other site 481805010647 putative AMP binding site [chemical binding]; other site 481805010648 putative active site [active] 481805010649 putative CoA binding site [chemical binding]; other site 481805010650 2-methylcitrate dehydratase; Provisional; Region: prpD; PRK09425 481805010651 2-methylcitrate dehydratase; Region: prpD; TIGR02330 481805010652 Citrate synthase [Energy production and conversion]; Region: GltA; COG0372 481805010653 Subgroup of Escherichia coli (Ec) 2-methylcitrate synthase (2MCS)_like. 2MCS catalyzes the condensation of propionyl-coenzyme A (PrCoA) and oxalacetate (OAA) to form 2-methylcitrate and coenzyme A (CoA) during propionate metabolism. Citrate synthase (CS)...; Region: Ec2MCS_like_1; cd06117 481805010654 dimer interface [polypeptide binding]; other site 481805010655 active site 481805010656 citrylCoA binding site [chemical binding]; other site 481805010657 oxalacetate/citrate binding site [chemical binding]; other site 481805010658 coenzyme A binding site [chemical binding]; other site 481805010659 catalytic triad [active] 481805010660 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 481805010661 Phosphoenolpyruvate phosphomutase; Region: PEP_mutase; pfam13714 481805010662 tetramer interface [polypeptide binding]; other site 481805010663 active site 481805010664 Mg2+/Mn2+ binding site [ion binding]; other site 481805010665 propionate catabolism operon regulatory protein PrpR; Provisional; Region: PRK15424 481805010666 Propionate catabolism activator; Region: PrpR_N; pfam06506 481805010667 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805010668 Walker A motif; other site 481805010669 ATP binding site [chemical binding]; other site 481805010670 Walker B motif; other site 481805010671 arginine finger; other site 481805010672 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 481805010673 hypothetical protein; Provisional; Region: PRK09929 481805010674 The Resistance to Homoserine/Threonine (RhtB) Family protein; Region: 2A76; TIGR00949 481805010675 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 481805010676 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 481805010677 putative NAD(P) binding site [chemical binding]; other site 481805010678 putative substrate binding site [chemical binding]; other site 481805010679 catalytic Zn binding site [ion binding]; other site 481805010680 structural Zn binding site [ion binding]; other site 481805010681 dimer interface [polypeptide binding]; other site 481805010682 putative deaminase; Validated; Region: PRK06846 481805010683 Bacterial cytosine deaminase and related metal-dependent hydrolases. Cytosine deaminases (CDs) catalyze the deamination of cytosine, producing uracil and ammonia. They play an important role in pyrimidine salvage. CDs are present in prokaryotes and fungi; Region: Bact_CD; cd01293 481805010684 active site 481805010685 carbamate kinase-like carbamoyl phosphate synthetase; Reviewed; Region: PRK12454 481805010686 AAK_CK: Carbamate kinase (CK) catalyzes both the ATP-phosphorylation of carbamate and carbamoyl phosphate (CP) utilization with the production of ATP from ADP and CP. Both CK (this CD) and nonhomologous CP synthetase synthesize carbamoyl phosphate, an...; Region: AAK_CK; cd04235 481805010687 putative substrate binding site [chemical binding]; other site 481805010688 nucleotide binding site [chemical binding]; other site 481805010689 nucleotide binding site [chemical binding]; other site 481805010690 homodimer interface [polypeptide binding]; other site 481805010691 Protein of unknown function (DUF1116); Region: DUF1116; pfam06545 481805010692 Succinyl-CoA synthetase, alpha subunit [Energy production and conversion]; Region: SucD; COG0074 481805010693 CoA binding domain; Region: CoA_binding; pfam02629 481805010694 CoA-ligase; Region: Ligase_CoA; pfam00549 481805010695 Protein of unknown function (DUF2877); Region: DUF2877; pfam11392 481805010696 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 481805010697 ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other...; Region: ANK; cd00204 481805010698 Ankyrin repeats (3 copies); Region: Ank_2; pfam12796 481805010699 Protein of unknown function (DUF1097); Region: DUF1097; pfam06496 481805010700 DNA-binding transcriptional activator AllS; Provisional; Region: PRK10094 481805010701 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805010702 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481805010703 dimerization interface [polypeptide binding]; other site 481805010704 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805010705 DNA binding residues [nucleotide binding] 481805010706 dimerization interface [polypeptide binding]; other site 481805010707 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805010708 choline transport protein BetT; Provisional; Region: PRK09928 481805010709 transcriptional regulator BetI; Validated; Region: PRK00767 481805010710 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481805010711 Bacterial transcriptional repressor; Region: TetR_C_6; pfam13977 481805010712 betaine aldehyde dehydrogenase; Provisional; Region: PRK13252 481805010713 NAD+-dependent 4-trimethylaminobutyraldehyde dehydrogenase, ALDH family 9A1; Region: ALDH_F9_TMBADH; cd07090 481805010714 tetrameric interface [polypeptide binding]; other site 481805010715 NAD binding site [chemical binding]; other site 481805010716 catalytic residues [active] 481805010717 choline dehydrogenase; Validated; Region: PRK02106 481805010718 GMC oxidoreductase; Region: GMC_oxred_C; pfam05199 481805010719 G-rich domain on putative tyrosine kinase; Region: GNVR; pfam13807 481805010720 Uncharacterized conserved protein [Function unknown]; Region: COG1556 481805010721 iron-sulfur cluster-binding protein; Region: TIGR00273 481805010722 Uncharacterized ACR, YkgG family COG1556; Region: DUF162; pfam02589 481805010723 The HCP family of iron-sulfur proteins includes hybrid cluster protein (HCP), acetyl-CoA synthase (ACS), and carbon monoxide dehydrogenase (CODH), all of which contain [Fe4-S4] metal clusters at their active sites. These proteins have a conserved...; Region: HCP_like; cl14655 481805010724 Domain of unknown function (DUF3390); Region: DUF3390; pfam11870 481805010725 Fe-S oxidoreductase [Energy production and conversion]; Region: GlpC; COG0247 481805010726 Cysteine-rich domain; Region: CCG; pfam02754 481805010727 Cysteine-rich domain; Region: CCG; pfam02754 481805010728 Cupin; Region: Cupin_6; pfam12852 481805010729 AraC-type DNA-binding domain-containing proteins [Transcription]; Region: AraC; COG2207 481805010730 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805010731 pyridine nucleotide-disulfide oxidoreductase; Provisional; Region: PRK08010 481805010732 ubiquinone biosynthesis hydroxylase family protein; Provisional; Region: PRK07608; cl17314 481805010733 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805010734 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 481805010735 Predicted membrane protein [Function unknown]; Region: COG3059 481805010736 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 481805010737 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805010738 Bacterial transcription activator, effector binding domain; Region: AraC_E_bind; smart00871 481805010739 Protein of unknown function (DUF3442); Region: DUF3442; pfam11924 481805010740 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 481805010741 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 481805010742 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 481805010743 Bacterial Ig-like domain (group 1); Region: BID_1; smart00634 481805010744 50S ribosomal protein L31 type B; Reviewed; Region: rpmE2; PRK01678 481805010745 50S ribosomal protein L36; Validated; Region: rpmJ; PRK00831 481805010746 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481805010747 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805010748 DNA binding residues [nucleotide binding] 481805010749 putative fimbrial protein TcfA; Provisional; Region: PRK15308 481805010750 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 481805010751 Peptidase associated domain: C-terminal domain of M14 N/E carboxypeptidase; putative folding, regulation, or interaction domain; Region: Peptidase_M14NE-CP-C_like; cl17499 481805010752 Predicted Fe-S-cluster oxidoreductase [General function prediction only]; Region: COG0727 481805010753 Predicted periplasmic/secreted protein [Function unknown]; Region: COG3477 481805010754 aldehyde oxidoreductase 2Fe-2S subunit; Provisional; Region: PRK11433 481805010755 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2; pfam00111 481805010756 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 481805010757 [2Fe-2S] binding domain; Region: Fer2_2; pfam01799 481805010758 Aerobic-type carbon monoxide dehydrogenase, middle subunit CoxM/CutM homologs [Energy production and conversion]; Region: CoxM; COG1319 481805010759 CO dehydrogenase flavoprotein C-terminal domain; Region: CO_deh_flav_C; smart01092 481805010760 Aerobic-type carbon monoxide dehydrogenase, large subunit CoxL/CutL homologs [Energy production and conversion]; Region: CoxL; COG1529 481805010761 Aldehyde oxidase and xanthine dehydrogenase, a/b hammerhead domain; Region: Ald_Xan_dh_C; pfam01315 481805010762 Molybdopterin-binding domain of aldehyde dehydrogenase; Region: Ald_Xan_dh_C2; pfam02738 481805010763 Xanthine and CO dehydrogenases maturation factor, XdhC/CoxF family [Posttranslational modification, protein turnover, chaperones]; Region: XdhC; COG1975 481805010764 XdhC and CoxI family; Region: XdhC_CoxI; pfam02625 481805010765 XdhC Rossmann domain; Region: XdhC_C; pfam13478 481805010766 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cl11398 481805010767 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481805010768 Gamma-glutamyl phosphate reductase (GPR), aldehyde dehydrogenase families 18 and 19; Region: ALDH_F18-19_ProA-GPR; cd07079 481805010769 gamma-glutamyl phosphate reductase; Region: proA; TIGR00407 481805010770 putative catalytic cysteine [active] 481805010771 gamma-glutamyl kinase; Provisional; Region: PRK05429 481805010772 AAK_G5K_ProB: Glutamate-5-kinase (G5K) catalyzes glutamate-dependent ATP cleavage; G5K transfers the terminal phosphoryl group of ATP to the gamma-carboxyl group of glutamate, in the first and controlling step of proline (and, in mammals, ornithine)...; Region: AAK_G5K_ProB; cd04242 481805010773 nucleotide binding site [chemical binding]; other site 481805010774 homotetrameric interface [polypeptide binding]; other site 481805010775 putative phosphate binding site [ion binding]; other site 481805010776 putative allosteric binding site; other site 481805010777 PUA domain; Region: PUA; pfam01472 481805010778 Outer membrane protein (porin) [Cell envelope biogenesis, outer membrane]; Region: OmpC; COG3203 481805010779 Porins form aqueous channels for the diffusion of small hydrophillic molecules across the outer membrane. Individual 16-strand anti-parallel beta-barrels form a central pore, and trimerizes thru mainly hydrophobic interactions at the interface. Trimers...; Region: gram_neg_porins; cd00342 481805010780 trimer interface [polypeptide binding]; other site 481805010781 eyelet of channel; other site 481805010782 DNA-binding transcriptional regulator Crl; Provisional; Region: PRK10984 481805010783 fermentation/respiration switch protein; Reviewed; Region: frsA; PRK05077 481805010784 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481805010785 active site 481805010786 Xaa-His dipeptidase; Region: aa-his-dipept; TIGR01893 481805010787 M20 Peptidase D has specificity for beta-alanyl-L-histidine dipeptide; Region: M20_pepD; cd03890 481805010788 metal binding site [ion binding]; metal-binding site 481805010789 dimer interface [polypeptide binding]; other site 481805010790 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805010791 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805010792 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805010793 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805010794 putative antitoxin of the YafO-YafN toxin-antitoxin system; Provisional; Region: PRK09778 481805010795 DNA Polymerase IV/Kappa; Region: PolY_Pol_IV_kappa; cd03586 481805010796 active site 481805010797 DNA polymerase IV; Validated; Region: PRK02406 481805010798 DNA binding site [nucleotide binding] 481805010799 hypothetical protein; Validated; Region: PRK06778 481805010800 Membrane MotB of proton-channel complex MotA/MotB; Region: MotB_plug; pfam13677 481805010801 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 481805010802 ligand binding site [chemical binding]; other site 481805010803 flagellar motor protein MotA; Provisional; Region: PRK12482 481805010804 Flagellar motor component [Cell motility and secretion]; Region: MotA; COG1291 481805010805 flagellar biosynthesis sigma factor; Provisional; Region: PRK12427 481805010806 Sigma-70 region 2; Region: Sigma70_r2; pfam04542 481805010807 Sigma-70, region 4; Region: Sigma70_r4; pfam04545 481805010808 DNA binding residues [nucleotide binding] 481805010809 Flagellar basal body-associated protein FliL; Region: FliL; pfam03748 481805010810 Flagellar hook-length control protein FliK; Region: Flg_hook; pfam02120 481805010811 Flagellar protein FliS; Region: FliS; cl00654 481805010812 Flagellar hook-associated protein 2 C-terminus; Region: FliD_N; pfam02465 481805010813 Flagellar hook-associated protein 2 C-terminus; Region: FliD_C; pfam07195 481805010814 flagellin; Reviewed; Region: PRK08869 481805010815 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 481805010816 Bacterial flagellin C-terminal helical region; Region: Flagellin_C; pfam00700 481805010817 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cl17355 481805010818 Response regulators consisting of a CheY-like receiver domain and a winged-helix DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: OmpR; COG0745 481805010819 DNA binding site [nucleotide binding] 481805010820 flagellar hook-associated protein FlgL; Reviewed; Region: flgL; PRK07192 481805010821 Bacterial flagellin N-terminal helical region; Region: Flagellin_N; pfam00669 481805010822 flagellar hook-associated protein FlgK; Validated; Region: flgK; PRK07191 481805010823 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 481805010824 Rod binding protein; Region: Rod-binding; cl01626 481805010825 flagellar basal body P-ring protein; Provisional; Region: flgI; PRK05303 481805010826 flagellar basal body P-ring protein; Reviewed; Region: flgI; cl14622 481805010827 flagellar basal body L-ring protein; Reviewed; Region: flgH; PRK12407 481805010828 Flagellar L-ring protein; Region: FlgH; pfam02107 481805010829 flagellar basal body rod protein FlgG; Provisional; Region: flgG; PRK12693 481805010830 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 481805010831 flagellar basal body rod protein FlgF; Reviewed; Region: flgF; PRK12640 481805010832 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 481805010833 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 481805010834 flagellar hook protein FlgE; Validated; Region: flgE; PRK06803 481805010835 Flagella basal body rod protein; Region: Flg_bb_rod; pfam00460 481805010836 Flagellar basal body protein FlaE; Region: FlaE; pfam07559 481805010837 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 481805010838 flagellar basal body rod modification protein; Reviewed; Region: flgD; PRK09619 481805010839 Flagellar hook capping protein - N-terminal region; Region: FlgD; pfam03963 481805010840 FlgD Tudor-like domain; Region: FLgD_tudor; pfam13861 481805010841 flagellar basal body rod protein FlgC; Reviewed; Region: flgC; PRK06802 481805010842 Flagellar basal body rod FlgEFG protein C-terminal; Region: Flg_bbr_C; pfam06429 481805010843 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK07182 481805010844 flagellar basal body rod protein FlgB; Reviewed; Region: flgB; PRK12685 481805010845 SAF-like; Region: SAF_2; pfam13144 481805010846 SAF domains of the flagella basal body P-ring formation protein FlgA and the flp pilus assembly CpaB; Region: SAF_CpaB_FlgA_like; cd11614 481805010847 Domains similar to fish antifreeze type III protein; Region: SAF; cl00555 481805010848 Anti-sigma-28 factor, FlgM; Region: FlgM; pfam04316 481805010849 FlgN protein; Region: FlgN; pfam05130 481805010850 Glycosyltransferases involved in cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WcaA; COG0463 481805010851 Glycosyltransferase family A (GT-A) includes diverse families of glycosyl transferases with a common GT-A type structural fold; Region: Glyco_tranf_GTA_type; cd00761 481805010852 active site 481805010853 Glycosyltransferase family 25 [lipooligosaccharide (LOS) biosynthesis protein] is a family of glycosyltransferases involved in LOS biosynthesis. The members include the beta(1,4) galactosyltransferases: Lgt2 of Moraxella catarrhalis, LgtB and LgtE of...; Region: Glyco_transf_25; cl01298 481805010854 nucleotidyl transferase superfamily; Region: nt_trans; cl00015 481805010855 active site 481805010856 nucleotide binding site [chemical binding]; other site 481805010857 HIGH motif; other site 481805010858 KMSKS motif; other site 481805010859 flagellar export protein FliJ; Region: flagell_FliJ; TIGR02473 481805010860 flagellum-specific ATP synthase; Validated; Region: fliI; PRK07196 481805010861 Flagellum-specific ATPase/type III secretory pathway virulence-related protein. This group of ATPases are responsible for the export of flagellum and virulence-related proteins. The bacterial flagellar motor is similar to the F0F1-ATPase, in that they...; Region: ATPase_flagellum-secretory_path_III; cd01136 481805010862 Walker A motif/ATP binding site; other site 481805010863 Walker B motif; other site 481805010864 flagellar assembly protein H; Provisional; Region: fliH; PRK13386 481805010865 Essential protein Yae1, N terminal; Region: Yae1_N; pfam09811 481805010866 Flagellar assembly protein FliH; Region: FliH; pfam02108 481805010867 flagellar motor switch protein G; Reviewed; Region: fliG; PRK07194 481805010868 MgtE intracellular N domain; Region: MgtE_N; smart00924 481805010869 FliG C-terminal domain; Region: FliG_C; pfam01706 481805010870 flagellar MS-ring protein; Reviewed; Region: fliF; PRK07193 481805010871 Secretory protein of YscJ/FliF family; Region: YscJ_FliF; cl01907 481805010872 Flagellar M-ring protein C-terminal; Region: YscJ_FliF_C; pfam08345 481805010873 Flagellar hook-basal body complex protein FliE; Region: FliE; pfam02049 481805010874 psp operon transcriptional activator PspF; Region: phageshock_pspF; TIGR02974 481805010875 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805010876 Walker A motif; other site 481805010877 ATP binding site [chemical binding]; other site 481805010878 Walker B motif; other site 481805010879 arginine finger; other site 481805010880 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 481805010881 Surface presentation of antigens (SPOA); Region: SpoA; pfam01052 481805010882 flagellar motor switch protein FliN; Region: fliN; TIGR02480 481805010883 flagellar biosynthesis protein FliP; Reviewed; Region: fliP; PRK05699 481805010884 Bacterial export proteins, family 3; Region: Bac_export_3; cl00867 481805010885 Flagellar biosynthesis pathway, component FliR [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FliR; COG1684 481805010886 flagellar biosynthesis protein FlhB; Reviewed; Region: flhB; PRK05702 481805010887 Uncharacterized homolog of the cytoplasmic domain of flagellar protein FhlB [Function unknown]; Region: COG2257; cl15822 481805010888 Flagellar biosynthesis pathway, component FlhA [Cell motility and secretion / Intracellular trafficking and secretion]; Region: FlhA; COG1298 481805010889 FHIPEP family; Region: FHIPEP; pfam00771 481805010890 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG1943 481805010891 Cell wall-associated hydrolases (invasion-associated proteins) [Cell envelope biogenesis, outer membrane]; Region: Spr; COG0791 481805010892 NlpC/P60 family; Region: NLPC_P60; pfam00877 481805010893 RelB antitoxin; Region: RelB; cl01171 481805010894 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3041 481805010895 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3034 481805010896 L,D-transpeptidase catalytic domain; Region: YkuD; pfam03734 481805010897 Predicted glutamine amidotransferase [General function prediction only]; Region: COG0121 481805010898 Glutamine amidotransferases class-II (Gn-AT)_YafJ-type. YafJ is a glutamine amidotransferase-like protein of unknown function found in prokaryotes, eukaryotes and archaea. YafJ has a conserved structural fold similar to those of other class II...; Region: YafJ; cd01908 481805010899 putative active site [active] 481805010900 putative dimer interface [polypeptide binding]; other site 481805010901 Phosphoheptose isomerase is a member of the SIS (Sugar ISomerase) superfamily. Phosphoheptose isomerase catalyzes the isomerization of sedoheptulose 7-phosphate into D-glycero-D-mannoheptose 7-phosphate. This is the first step of the biosynthesis of...; Region: SIS_GmhA; cd05006 481805010902 dimer interface [polypeptide binding]; other site 481805010903 active site 481805010904 acyl-CoA dehydrogenase; Reviewed; Region: fadE; PRK09463 481805010905 Acyl-CoA dehydrogenase; Region: ACAD; cl09933 481805010906 active site 481805010907 Domain of unknown function (DUF1974); Region: DUF1974; pfam09317 481805010908 C-lysozyme inhibitor; Provisional; Region: PRK09993 481805010909 C-N hydrolase family amidase; Provisional; Region: PRK10438 481805010910 Xanthomonas campestris XC1258 and related proteins, members of the nitrilase superfamily (putative class 13 nitrilases); Region: Xc-1258_like; cd07575 481805010911 putative active site [active] 481805010912 catalytic triad [active] 481805010913 dimer interface [polypeptide binding]; other site 481805010914 multimer interface [polypeptide binding]; other site 481805010915 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 481805010916 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 481805010917 Transposase; Region: HTH_Tnp_1; pfam01527 481805010918 putative transposase OrfB; Reviewed; Region: PHA02517 481805010919 HTH-like domain; Region: HTH_21; pfam13276 481805010920 Integrase core domain; Region: rve; pfam00665 481805010921 Integrase core domain; Region: rve_2; pfam13333 481805010922 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 481805010923 Transposase; Region: HTH_Tnp_1; pfam01527 481805010924 DNA-binding interface [nucleotide binding]; DNA binding site 481805010925 Helix-turn-helix domain; Region: HTH_38; pfam13936 481805010926 Winged helix-turn helix; Region: HTH_29; pfam13551 481805010927 Integrase core domain; Region: rve; pfam00665 481805010928 putative transposase OrfB; Reviewed; Region: PHA02517 481805010929 Integrase core domain; Region: rve; pfam00665 481805010930 Integrase core domain; Region: rve_3; pfam13683 481805010931 heavy metal sensor kinase; Region: cztS_silS_copS; TIGR01386 481805010932 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805010933 dimerization interface [polypeptide binding]; other site 481805010934 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805010935 dimer interface [polypeptide binding]; other site 481805010936 phosphorylation site [posttranslational modification] 481805010937 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805010938 ATP binding site [chemical binding]; other site 481805010939 Mg2+ binding site [ion binding]; other site 481805010940 G-X-G motif; other site 481805010941 heavy metal response regulator; Region: cztR_silR_copR; TIGR01387 481805010942 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805010943 active site 481805010944 phosphorylation site [posttranslational modification] 481805010945 intermolecular recognition site; other site 481805010946 dimerization interface [polypeptide binding]; other site 481805010947 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805010948 DNA binding site [nucleotide binding] 481805010949 Putative copper export protein [Inorganic ion transport and metabolism]; Region: PcoD; COG1276 481805010950 CopC domain; Region: CopC; pfam04234 481805010951 Copper resistance protein B precursor (CopB); Region: CopB; pfam05275 481805010952 copper-resistance protein, CopA family; Region: copper_res_A; TIGR01480 481805010953 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 481805010954 Multicopper oxidase; Region: Cu-oxidase; pfam00394 481805010955 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 481805010956 Peptidase family M23; Region: Peptidase_M23; pfam01551 481805010957 Protein of unknown function (DUF2933); Region: DUF2933; pfam11666 481805010958 YHS domain; Region: YHS; pfam04945 481805010959 copper-(or silver)-translocating P-type ATPase; Region: ATPase-IB1_Cu; TIGR01511 481805010960 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 481805010961 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805010962 motif II; other site 481805010963 Protein of unknown function, DUF; Region: DUF411; cl01142 481805010964 heavy metal efflux pump, CzcA family; Region: 2A0601; TIGR00914 481805010965 copper/silver efflux system membrane fusion protein CusB; Provisional; Region: PRK09783 481805010966 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805010967 periplasmic copper-binding protein; Provisional; Region: PRK09838 481805010968 copper/silver efflux system outer membrane protein CusC; Provisional; Region: PRK09837 481805010969 DNA-binding transcriptional activator CusR; Provisional; Region: PRK09836 481805010970 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805010971 active site 481805010972 phosphorylation site [posttranslational modification] 481805010973 intermolecular recognition site; other site 481805010974 dimerization interface [polypeptide binding]; other site 481805010975 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805010976 DNA binding site [nucleotide binding] 481805010977 sensor kinase CusS; Provisional; Region: PRK09835 481805010978 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805010979 dimerization interface [polypeptide binding]; other site 481805010980 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805010981 dimer interface [polypeptide binding]; other site 481805010982 phosphorylation site [posttranslational modification] 481805010983 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805010984 ATP binding site [chemical binding]; other site 481805010985 Mg2+ binding site [ion binding]; other site 481805010986 G-X-G motif; other site 481805010987 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3544 481805010988 Uncharacterized conserved protein [Function unknown]; Region: COG5464 481805010989 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 481805010990 Predicted GTPase [General function prediction only]; Region: COG3596 481805010991 YfjP GTPase; Region: YfjP; cd11383 481805010992 G1 box; other site 481805010993 GTP/Mg2+ binding site [chemical binding]; other site 481805010994 Switch I region; other site 481805010995 G2 box; other site 481805010996 Switch II region; other site 481805010997 G3 box; other site 481805010998 G4 box; other site 481805010999 G5 box; other site 481805011000 Predicted transcriptional regulator [Transcription]; Region: COG2378 481805011001 Stage III sporulation protein D; Region: SpoIIID; cl17560 481805011002 WYL domain; Region: WYL; pfam13280 481805011003 Domain of unknown function (DUF4339); Region: DUF4339; pfam14237 481805011004 SH3 domain-containing protein; Provisional; Region: PRK10884 481805011005 Bacterial protein of unknown function (DUF905); Region: DUF905; pfam06006 481805011006 Domain of unknown function (DUF932); Region: DUF932; pfam06067 481805011007 Antirestriction protein; Region: Antirestrict; pfam03230 481805011008 Mov34/MPN/PAD-1 family; Region: MPN_DUF2466; cd08071 481805011009 MPN+ (JAMM) motif; other site 481805011010 Zinc-binding site [ion binding]; other site 481805011011 Protein of unknown function (DUF987); Region: DUF987; pfam06174 481805011012 YagB/YeeU/YfjZ family; Region: YagB_YeeU_YfjZ; pfam06154 481805011013 Protein of unknown function (DUF1219); Region: DUF1219; pfam06755 481805011014 PyridoxaL 5'-Phosphate Dependent Enzymes class IV (PLPDE_IV). This D-amino acid superfamily, one of five classes of PLPDE, consists of branched-chain amino acid aminotransferases (BCAT), D-amino acid transferases (DAAT), and...; Region: PLPDE_IV; cl00224 481805011015 catalytic residue [active] 481805011016 Enterobacterial protein of unknown function (DUF957); Region: DUF957; pfam06117 481805011017 DNA polymerase III, epsilon subunit, Proteobacterial; Region: dnaQ_proteo; TIGR01406 481805011018 DEDDh 3'-5' exonuclease domain of the epsilon subunit of Escherichia coli DNA polymerase III and similar proteins; Region: DNA_pol_III_epsilon_Ecoli_like; cd06131 481805011019 active site 481805011020 catalytic site [active] 481805011021 substrate binding site [chemical binding]; other site 481805011022 RNase HI family found mainly in prokaryotes; Region: RNase_HI_prokaryote_like; cd09278 481805011023 RNA/DNA hybrid binding site [nucleotide binding]; other site 481805011024 active site 481805011025 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805011026 hydroxyacylglutathione hydrolase; Provisional; Region: PRK10241 481805011027 membrane-bound lytic murein transglycosylase D; Provisional; Region: mltD; PRK10783 481805011028 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 481805011029 N-acetyl-D-glucosamine binding site [chemical binding]; other site 481805011030 catalytic residue [active] 481805011031 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481805011032 Lysine Motif is a small domain involved in binding peptidoglycan; Region: LysM; cd00118 481805011033 Methyltransferase domain; Region: Methyltransf_31; pfam13847 481805011034 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805011035 S-adenosylmethionine binding site [chemical binding]; other site 481805011036 hypothetical protein; Provisional; Region: PRK05421 481805011037 putative catalytic site [active] 481805011038 putative metal binding site [ion binding]; other site 481805011039 putative phosphate binding site [ion binding]; other site 481805011040 putative catalytic site [active] 481805011041 putative phosphate binding site [ion binding]; other site 481805011042 putative metal binding site [ion binding]; other site 481805011043 Transcriptional regulator [Transcription]; Region: LysR; COG0583 481805011044 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805011045 The C-terminal substrate binding domain of LysR-type transcriptional regulator CrgA, contains the type 2 periplasmic binding domain; Region: PBP2_CrgA; cd08478 481805011046 putative effector binding pocket; other site 481805011047 dimerization interface [polypeptide binding]; other site 481805011048 Aldo-keto reductases (AKRs) are a superfamily of soluble NAD(P)(H) oxidoreductases whose chief purpose is to reduce aldehydes and ketones to primary and secondary alcohols. AKRs are present in all phyla and are of importance to both health and industrial...; Region: Aldo_ket_red; cd06660 481805011049 Aldo/keto reductase family; Region: Aldo_ket_red; pfam00248 481805011050 active site 481805011051 catalytic tetrad [active] 481805011052 D,D-heptose 1,7-bisphosphate phosphatase; Region: GmhB_yaeD; TIGR00213 481805011053 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805011054 active site 481805011055 motif I; other site 481805011056 motif II; other site 481805011057 DL-methionine transporter ATP-binding subunit; Provisional; Region: metN; PRK11153 481805011058 ATP-binding cassette domain of methionine transporter; Region: ABC_MetN_methionine_transporter; cd03258 481805011059 Walker A/P-loop; other site 481805011060 ATP binding site [chemical binding]; other site 481805011061 Q-loop/lid; other site 481805011062 ABC transporter signature motif; other site 481805011063 Walker B; other site 481805011064 D-loop; other site 481805011065 H-loop/switch region; other site 481805011066 This domain is found at the C-terminus of ABC transporter proteins involved in D-methionine transport as well as a number of ferredoxin-like proteins; Region: NIL; smart00930 481805011067 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805011068 dimer interface [polypeptide binding]; other site 481805011069 conserved gate region; other site 481805011070 ABC-ATPase subunit interface; other site 481805011071 DL-methionine transporter substrate-binding subunit; Provisional; Region: metQ; PRK11063 481805011072 lipoprotein, YaeC family; Region: TIGR00363 481805011073 outer membrane lipoprotein; Reviewed; Region: rcsF; PRK10781 481805011074 Escherichia coli YaeB and related proteins; Region: UPF0066; cd09281 481805011075 homodimer interaction site [polypeptide binding]; other site 481805011076 cofactor binding site; other site 481805011077 prolyl-tRNA synthetase; Provisional; Region: PRK09194 481805011078 Prolyl-tRNA synthetase (ProRS) class II core catalytic domain. ProRS is a homodimer. It is responsible for the attachment of proline to the 3' OH group of ribose of the appropriate tRNA. This domain is primarily responsible for ATP-dependent...; Region: ProRS_core_prok; cd00779 481805011079 dimer interface [polypeptide binding]; other site 481805011080 motif 1; other site 481805011081 active site 481805011082 motif 2; other site 481805011083 INS is an amino acid-editing domain inserted (INS) into the bacterial class II prolyl-tRNA synthetase (ProRS) however, this CD is not exclusively bacterial. It is also found at the N-terminus of the eukaryotic/archaea-like ProRS's of yeasts and...; Region: ProRS-INS; cd04334 481805011084 putative deacylase active site [active] 481805011085 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 481805011086 active site 481805011087 motif 3; other site 481805011088 ProRS Prolyl-anticodon binding domain, short version found predominantly in bacteria. ProRS belongs to class II aminoacyl-tRNA synthetases (aaRS). This alignment contains the anticodon binding domain, which is responsible for specificity in tRNA-binding; Region: ProRS_anticodon_short; cd00861 481805011089 anticodon binding site; other site 481805011090 hypothetical protein; Provisional; Region: PRK11479 481805011091 Orthopoxvirus protein of unknown function (DUF830); Region: DUF830; cl13998 481805011092 lipoprotein involved with copper homeostasis and adhesion; Provisional; Region: PRK10523 481805011093 NlpE N-terminal domain; Region: NlpE; pfam04170 481805011094 hypothetical protein; Provisional; Region: PRK09256 481805011095 Protein chain release factor B [Translation, ribosomal structure and biogenesis]; Region: PrfB; COG1186 481805011096 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4681 481805011097 hypothetical protein; Provisional; Region: PRK04964 481805011098 Rho-binding antiterminator; Provisional; Region: PRK11625 481805011099 tRNA(Ile)-lysidine synthetase; Provisional; Region: tilS; PRK10660 481805011100 N-terminal domain of predicted ATPase of the PP-loop faimly implicated in cell cycle control [Cell division and chromosome partitioning]. This is a subfamily of Adenine nucleotide alpha hydrolases superfamily.Adeninosine nucleotide alpha hydrolases...; Region: PP-ATPase; cd01992 481805011101 Ligand Binding Site [chemical binding]; other site 481805011102 TilS substrate binding domain; Region: TilS; pfam09179 481805011103 TilS substrate C-terminal domain; Region: TilS_C; pfam11734 481805011104 This conserved domain belongs to a superfamily including the bleomycin resistance protein, glyoxalase I, and type I ring-cleaving dioxygenases; Region: Glo_EDI_BRP_like_1; cd08352 481805011105 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481805011106 putative metal binding site [ion binding]; other site 481805011107 lysine decarboxylase LdcC; Provisional; Region: PRK15399 481805011108 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 481805011109 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 481805011110 homodimer interface [polypeptide binding]; other site 481805011111 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805011112 catalytic residue [active] 481805011113 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 481805011114 acetyl-CoA carboxylase carboxyltransferase subunit alpha; Validated; Region: PRK05724 481805011115 acetyl-CoA carboxylase carboxyltransferase alpha subunit; Provisional; Region: accA; CHL00198 481805011116 DNA polymerase III subunit alpha; Validated; Region: dnaE; PRK05673 481805011117 Polymerase and Histidinol Phosphatase domain of alpha-subunit of bacterial polymerase III DnaE1; Region: PHP_PolIIIA_DnaE1; cd07433 481805011118 putative active site [active] 481805011119 putative PHP Thumb interface [polypeptide binding]; other site 481805011120 DnaE_OBF: A subfamily of OB folds corresponding to the C-terminal OB-fold nucleic acid binding domain of Thermus aquaticus and Escherichia coli type C replicative DNA polymerase III alpha subunit (DnaE). The DNA polymerase holoenzyme of E. coli contains...; Region: DnaE_OBF; cd04485 481805011121 generic binding surface II; other site 481805011122 generic binding surface I; other site 481805011123 bacterial Ribonuclease HII-like; Region: RNase_HII_bacteria_HII_like; cd07182 481805011124 RNA/DNA hybrid binding site [nucleotide binding]; other site 481805011125 active site 481805011126 lipid-A-disaccharide synthase; Reviewed; Region: lpxB; PRK00025 481805011127 ipid-A-disaccharide synthase; Provisional; Region: PRK14089 481805011128 UDP-N-acetylglucosamine acyltransferase; Provisional; Region: PRK05289 481805011129 UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic...; Region: LbH_UDP-GlcNAc_AT; cd03351 481805011130 active site 481805011131 FabZ is a 17kD beta-hydroxyacyl-acyl carrier protein (ACP) dehydratase that primarily catalyzes the dehydration of beta-hydroxyacyl-ACP to trans-2-acyl-ACP, the third step in the elongation phase of the bacterial/ plastid, type II, fatty-acid...; Region: FabZ; cd01288 481805011132 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase; Provisional; Region: lpxD; PRK00892 481805011133 UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase, LpxD; Region: LpxD; pfam04613 481805011134 UDP-3-O-acyl-glucosamine N-acyltransferase (LpxD): The enzyme catalyzes the transfer of 3-hydroxymyristic acid or 3-hydroxy-arachidic acid, depending on the organism, from the acyl carrier protein (ACP) to UDP-3-O-acyl-glucosamine to produce UDP-2; Region: LbH_LpxD; cd03352 481805011135 trimer interface [polypeptide binding]; other site 481805011136 active site 481805011137 UDP-GlcNAc binding site [chemical binding]; other site 481805011138 lipid binding site [chemical binding]; lipid-binding site 481805011139 periplasmic chaperone; Provisional; Region: PRK10780 481805011140 Outer membrane protein (OmpH-like); Region: OmpH; smart00935 481805011141 outer membrane protein assembly factor YaeT; Provisional; Region: PRK11067 481805011142 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 481805011143 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 481805011144 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 481805011145 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 481805011146 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 481805011147 Surface antigen; Region: Bac_surface_Ag; pfam01103 481805011148 zinc metallopeptidase RseP; Provisional; Region: PRK10779 481805011149 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 481805011150 active site 481805011151 PDZ domain of bacterial and plant zinc metalloprotases, presumably membrane-associated or integral membrane proteases, which may be involved in signalling and regulatory mechanisms. May be responsible for substrate recognition and/or binding, as most PDZ...; Region: PDZ_metalloprotease; cd00989 481805011152 protein binding site [polypeptide binding]; other site 481805011153 RseP-like Site-2 proteases (S2P), zinc metalloproteases (MEROPS family M50A), cleave transmembrane domains of substrate proteins, regulating intramembrane proteolysis (RIP) of diverse signal transduction mechanisms. In Escherichia coli, the S2P homolog...; Region: S2P-M50_PDZ_RseP-like; cd06163 481805011154 putative substrate binding region [chemical binding]; other site 481805011155 CDP-diglyceride synthase; Provisional; Region: cdsA; PRK11624 481805011156 CDP-diglyceride synthetase [Lipid metabolism]; Region: CdsA; COG0575 481805011157 Undecaprenyl pyrophosphate synthase [Lipid metabolism]; Region: UppS; COG0020 481805011158 Cis (Z)-Isoprenyl Diphosphate Synthases (cis-IPPS); homodimers which catalyze the successive 1'-4 condensation of the isopentenyl diphosphate (IPP) molecule to trans,trans-farnesyl diphosphate (FPP) or to cis,trans-FPP to form long-chain polyprenyl...; Region: CIS_IPPS; cd00475 481805011159 catalytic residue [active] 481805011160 putative FPP diphosphate binding site; other site 481805011161 putative FPP binding hydrophobic cleft; other site 481805011162 dimer interface [polypeptide binding]; other site 481805011163 putative IPP diphosphate binding site; other site 481805011164 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Provisional; Region: PRK05447 481805011165 1-deoxy-D-xylulose 5-phosphate reductoisomerase; Region: DXP_reductoisom; pfam02670 481805011166 1-deoxy-D-xylulose 5-phosphate reductoisomerase C-terminal; Region: DXP_redisom_C; pfam08436 481805011167 DXP reductoisomerase C-terminal domain; Region: DXPR_C; pfam13288 481805011168 ribosome recycling factor; Reviewed; Region: frr; PRK00083 481805011169 Ribosome recycling factor (RRF). Ribosome recycling factor dissociates the posttermination complex, composed of the ribosome, deacylated tRNA, and mRNA, after termination of translation. Thus ribosomes are "recycled" and ready for another...; Region: RRF; cd00520 481805011170 hinge region; other site 481805011171 UMP kinase (UMPK)-Ec, the microbial/chloroplast uridine monophosphate kinase (uridylate kinase) enzyme that catalyzes UMP phosphorylation and plays a key role in pyrimidine nucleotide biosynthesis; regulation of this process is via feed-back control and...; Region: AAK_UMPK-PyrH-Ec; cd04254 481805011172 putative nucleotide binding site [chemical binding]; other site 481805011173 uridine monophosphate binding site [chemical binding]; other site 481805011174 homohexameric interface [polypeptide binding]; other site 481805011175 elongation factor Ts; Provisional; Region: tsf; PRK09377 481805011176 UBA/TS-N domain; Region: UBA; pfam00627 481805011177 Elongation factor TS; Region: EF_TS; pfam00889 481805011178 Elongation factor TS; Region: EF_TS; pfam00889 481805011179 Ribosomal protein S2 (RPS2), involved in formation of the translation initiation complex, where it might contact the messenger RNA and several components of the ribosome. It has been shown that in Escherichia coli RPS2 is essential for the binding of...; Region: RPS2; cd01425 481805011180 rRNA interaction site [nucleotide binding]; other site 481805011181 S8 interaction site; other site 481805011182 putative laminin-1 binding site; other site 481805011183 Methionine Aminopeptidase 1. E.C. 3.4.11.18. Also known as methionyl aminopeptidase and Peptidase M. Catalyzes release of N-terminal amino acids, preferentially methionine, from peptides and arylamides; Region: MetAP1; cd01086 481805011184 active site 481805011185 PII uridylyl-transferase; Provisional; Region: PRK05007 481805011186 Nucleotidyltransferase (NT) domain of Escherichia coli adenylyltransferase (GlnE), Escherichia coli uridylyl transferase (GlnD), and similar proteins; Region: NT_GlnE_GlnD_like; cd05401 481805011187 metal binding triad; other site 481805011188 GlnD PII-uridylyltransferase; Region: GlnD_UR_UTase; pfam08335 481805011189 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481805011190 Zn2+ binding site [ion binding]; other site 481805011191 Mg2+ binding site [ion binding]; other site 481805011192 ACT domain family, ACT_UUR-like_1, includes the first of two C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_UUR-like_1; cd04900 481805011193 C-terminal ACT domains of the bacterial signal-transducing uridylyltransferase /uridylyl-removing (UUR) enzyme, GlnD and related domains; Region: ACT_ACR-UUR-like_2; cd04899 481805011194 2,3,4,5-tetrahydropyridine-2,6-carboxylate N-succinyltransferase; Provisional; Region: dapD; PRK11830 481805011195 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (also called THP succinyltransferase): THDP N-succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA; Region: LbH_THP_succinylT; cd03350 481805011196 trimer interface [polypeptide binding]; other site 481805011197 active site 481805011198 substrate binding site [chemical binding]; other site 481805011199 CoA binding site [chemical binding]; other site 481805011200 phosphodiesterase YaeI; Provisional; Region: PRK11340 481805011201 Bacillus subtilis YkuE and related proteins, C-terminal metallophosphatase domain; Region: MPP_YkuE_C; cd07385 481805011202 putative active site [active] 481805011203 putative metal binding site [ion binding]; other site 481805011204 hypothetical protein; Provisional; Region: PRK13677 481805011205 carbohydrate diacid transcriptional activator CdaR; Provisional; Region: PRK11477 481805011206 Putative sugar diacid recognition; Region: Diacid_rec; pfam05651 481805011207 PucR C-terminal helix-turn-helix domain; Region: HTH_30; pfam13556 481805011208 serine endoprotease; Provisional; Region: PRK10942 481805011209 Trypsin-like peptidase domain; Region: Trypsin_2; pfam13365 481805011210 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 481805011211 protein binding site [polypeptide binding]; other site 481805011212 PDZ domain of tryspin-like serine proteases, such as DegP/HtrA, which are oligomeric proteins involved in heat-shock response, chaperone function, and apoptosis. May be responsible for substrate recognition and/or binding, as most PDZ domains bind...; Region: PDZ_serine_protease; cd00987 481805011213 deoxyguanosinetriphosphate triphosphohydrolase; Provisional; Region: dgt; PRK04926 481805011214 Metal dependent phosphohydrolases with conserved 'HD' motif; Region: HDc; cd00077 481805011215 Zn2+ binding site [ion binding]; other site 481805011216 Mg2+ binding site [ion binding]; other site 481805011217 Phosphohydrolase-associated domain; Region: HD_assoc; pfam13286 481805011218 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Validated; Region: PRK05584 481805011219 5'-methylthioadenosine/S-adenosylhomocysteine nucleosidase; Region: MTA/SAH-Nsdase; TIGR01704 481805011220 vitamin B12-transporter protein BtuF; Provisional; Region: PRK03379 481805011221 Cobalamin binding protein BtuF. These proteins have been shown to function as initial receptors in ABC transport of vitamin B12 (cobalamin) in eubacterial and some archaeal species. They belong to the TroA superfamily of helical backbone metal receptor...; Region: BtuF; cd01144 481805011222 cobalamin binding residues [chemical binding]; other site 481805011223 putative BtuC binding residues; other site 481805011224 dimer interface [polypeptide binding]; other site 481805011225 hypothetical protein; Provisional; Region: PRK10578 481805011226 UPF0126 domain; Region: UPF0126; pfam03458 481805011227 UPF0126 domain; Region: UPF0126; pfam03458 481805011228 iron-sulfur cluster insertion protein ErpA; Provisional; Region: PRK13623 481805011229 Chloride channel protein EriC [Inorganic ion transport and metabolism]; Region: EriC; COG0038 481805011230 ClC chloride channel EriC. This domain is found in the EriC chloride transporters that mediate the extreme acid resistance response in eubacteria and archaea. This response allows bacteria to survive in the acidic environments by decarboxylation-linked...; Region: EriC; cd01031 481805011231 Cl- selectivity filter; other site 481805011232 Cl- binding residues [ion binding]; other site 481805011233 pore gating glutamate residue; other site 481805011234 dimer interface [polypeptide binding]; other site 481805011235 H+/Cl- coupling transport residue; other site 481805011236 glutamate-1-semialdehyde aminotransferase; Provisional; Region: PRK00062 481805011237 Acetyl ornithine aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD correspond to ornithine aminotransferase, acetylornithine aminotransferase; Region: OAT_like; cd00610 481805011238 inhibitor-cofactor binding pocket; inhibition site 481805011239 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805011240 catalytic residue [active] 481805011241 iron-hydroxamate transporter permease subunit; Provisional; Region: PRK10577 481805011242 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481805011243 ABC-ATPase subunit interface; other site 481805011244 dimer interface [polypeptide binding]; other site 481805011245 putative PBP binding regions; other site 481805011246 Transmembrane subunit (TM), of Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters involved in the uptake of siderophores, heme, vitamin B12, or the divalent cations Mg2+ and Zn2+. PBP-dependent ABC transporters consist of...; Region: TM_ABC_iron-siderophores_like; cd06550 481805011247 ABC-ATPase subunit interface; other site 481805011248 dimer interface [polypeptide binding]; other site 481805011249 putative PBP binding regions; other site 481805011250 Fe3+-siderophore binding domain FhuD. These proteins have been shown to function as initial receptors in ABC transport of Fe3+-siderophores in many eubacterial species. They belong to the TroA-like superfamily of helical backbone metal receptor proteins...; Region: FhuD; cd01146 481805011251 Periplasmic binding protein; Region: Peripla_BP_2; pfam01497 481805011252 siderophore binding site; other site 481805011253 iron-hydroxamate transporter ATP-binding subunit; Provisional; Region: PRK10575 481805011254 ATP-binding component of iron-siderophores, vitamin B12 and hemin transporters and related proteins; Region: ABC_Iron-Siderophores_B12_Hemin; cd03214 481805011255 Walker A/P-loop; other site 481805011256 ATP binding site [chemical binding]; other site 481805011257 Q-loop/lid; other site 481805011258 ABC transporter signature motif; other site 481805011259 Walker B; other site 481805011260 D-loop; other site 481805011261 H-loop/switch region; other site 481805011262 ferrichrome outer membrane transporter; Provisional; Region: PRK10044 481805011263 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 481805011264 N-terminal plug; other site 481805011265 ligand-binding site [chemical binding]; other site 481805011266 bifunctional glycosyl transferase/transpeptidase; Reviewed; Region: mrcB; PRK09506 481805011267 Transglycosylase; Region: Transgly; pfam00912 481805011268 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; cl17760 481805011269 ATP-dependent RNA helicase HrpB; Provisional; Region: PRK11664 481805011270 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481805011271 ATP binding site [chemical binding]; other site 481805011272 putative Mg++ binding site [ion binding]; other site 481805011273 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805011274 nucleotide binding region [chemical binding]; other site 481805011275 ATP-binding site [chemical binding]; other site 481805011276 Helicase associated domain (HA2) Add an annotation; Region: HA2; smart00847 481805011277 ATP-dependent helicase C-terminal; Region: HrpB_C; pfam08482 481805011278 2'-5' RNA ligase; Provisional; Region: PRK15124 481805011279 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 481805011280 LigT like Phosphoesterase; Region: LigT_PEase; pfam02834 481805011281 putative DNA-binding transcriptional regulator; Reviewed; Region: PRK00347 481805011282 RNA polymerase-binding transcription factor; Provisional; Region: dksA; PRK10778 481805011283 glutamyl-Q tRNA(Asp) synthetase; Reviewed; Region: PRK05710 481805011284 tRNA synthetases class I (E and Q), catalytic domain; Region: tRNA-synt_1c; pfam00749 481805011285 active site 481805011286 nucleotide binding site [chemical binding]; other site 481805011287 HIGH motif; other site 481805011288 KMSKS motif; other site 481805011289 poly(A) polymerase I; Provisional; Region: pcnB; PRK11623 481805011290 Nucleotidyltransferase (NT) domain of ClassII CCA-adding enzymes; Region: NT_ClassII-CCAase; cd05398 481805011291 active site 481805011292 NTP binding site [chemical binding]; other site 481805011293 metal binding triad [ion binding]; metal-binding site 481805011294 Probable RNA and SrmB- binding site of polymerase A; Region: PolyA_pol_RNAbd; pfam12627 481805011295 Polymerase A arginine-rich C-terminus; Region: PolyA_pol_arg_C; pfam12626 481805011296 7,8-dihydro-6-hydroxymethylpterin-pyrophosphokinase (HPPK). Folate derivatives are essential cofactors in the biosynthesis of purines, pyrimidines, and amino acids as well as formyl-tRNA. Mammalian cells are able to utilize pre-formed folates after...; Region: HPPK; cd00483 481805011297 catalytic center binding site [active] 481805011298 ATP binding site [chemical binding]; other site 481805011299 Fimbrial protein; Region: Fimbrial; cl01416 481805011300 putative chaperone protein EcpD; Provisional; Region: PRK09926 481805011301 Gram-negative pili assembly chaperone, N-terminal domain; Region: Pili_assembly_N; pfam00345 481805011302 Gram-negative pili assembly chaperone, C-terminal domain; Region: Pili_assembly_C; pfam02753 481805011303 putative fimbrial outer membrane usher protein; Provisional; Region: PRK09828 481805011304 PapC N-terminal domain; Region: PapC_N; pfam13954 481805011305 Type VII secretion system (T7SS), usher protein; Region: Usher; pfam00577 481805011306 PapC C-terminal domain; Region: PapC_C; pfam13953 481805011307 Fimbrial protein; Region: Fimbrial; cl01416 481805011308 putative fimbrial protein StaE; Provisional; Region: PRK15263 481805011309 putative fimbrial protein StaF; Provisional; Region: PRK15262 481805011310 Fimbrial protein; Region: Fimbrial; cl01416 481805011311 Ketopantoate hydroxymethyltransferase (KPHMT) is the first enzyme in the pantothenate biosynthesis pathway. Ketopantoate hydroxymethyltransferase (KPHMT) catalyzes the first committed step in the biosynthesis of pantothenate (vitamin B5), which is a...; Region: KPHMT-like; cd06557 481805011312 oligomerization interface [polypeptide binding]; other site 481805011313 active site 481805011314 metal binding site [ion binding]; metal-binding site 481805011315 pantoate--beta-alanine ligase; Region: panC; TIGR00018 481805011316 Pantoate-beta-alanine ligase; Region: PanC; cd00560 481805011317 active site 481805011318 ATP-binding site [chemical binding]; other site 481805011319 pantoate-binding site; other site 481805011320 HXXH motif; other site 481805011321 Uncharacterized conserved protein [Function unknown]; Region: COG5464 481805011322 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 481805011323 Aspartate alpha-decarboxylase or L-aspartate 1-decarboxylase, a pyruvoyl group-dependent decarboxylase in beta-alanine production; Region: Asp_decarbox; cd06919 481805011324 tetramerization interface [polypeptide binding]; other site 481805011325 active site 481805011326 Putative catalytic polysaccharide deacetylase domain of uncharacterized protein yadE and similar proteins; Region: CE4_yadE_5s; cd10966 481805011327 putative active site [active] 481805011328 putative metal binding site [ion binding]; other site 481805011329 PTS_IIA, PTS system, mannose/sorbose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_man; cd00006 481805011330 active pocket/dimerization site; other site 481805011331 active site 481805011332 phosphorylation site [posttranslational modification] 481805011333 inner membrane transport permease; Provisional; Region: PRK15066 481805011334 ABC-type multidrug transport system, permease component [Defense mechanisms]; Region: COG0842 481805011335 ABC-type multidrug transport system, ATPase component [Defense mechanisms]; Region: CcmA; COG1131 481805011336 ATP-binding cassette domain of the drug resistance transporter and related proteins, subfamily A; Region: ABC_DR_subfamily_A; cd03230 481805011337 Walker A/P-loop; other site 481805011338 ATP binding site [chemical binding]; other site 481805011339 Q-loop/lid; other site 481805011340 ABC transporter signature motif; other site 481805011341 Walker B; other site 481805011342 D-loop; other site 481805011343 H-loop/switch region; other site 481805011344 Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-step mechanism in which the nucleophilic attack of a zinc-bound hydroxide ion on carbon dioxide is followed by the regeneration of an...; Region: beta_CA_cladeA; cd00883 481805011345 active site clefts [active] 481805011346 zinc binding site [ion binding]; other site 481805011347 dimer interface [polypeptide binding]; other site 481805011348 Phosphoribosyl transferase (PRT)-type I domain; Region: PRTases_typeI; cd06223 481805011349 active site 481805011350 membrane-bound PQQ-dependent dehydrogenase, glucose/quinate/shikimate family; Region: PQQ_membr_DH; TIGR03074 481805011351 Membrane-bound PQQ-dependent glucose dehydrogenase; Region: PQQ_mGDH; cd10280 481805011352 Trp docking motif [polypeptide binding]; other site 481805011353 putative active site [active] 481805011354 multicopper oxidase; Provisional; Region: PRK10965 481805011355 Multicopper oxidase; Region: Cu-oxidase_3; pfam07732 481805011356 Multicopper oxidase; Region: Cu-oxidase; pfam00394 481805011357 Multicopper oxidase; Region: Cu-oxidase_2; pfam07731 481805011358 Bacterial chaperone lipoprotein (PulS_OutS); Region: PulS_OutS; cl09898 481805011359 spermidine synthase; Provisional; Region: PRK00811 481805011360 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805011361 S-adenosylmethionine binding site [chemical binding]; other site 481805011362 S-adenosylmethionine decarboxylase; Provisional; Region: PRK05462 481805011363 hypothetical protein; Provisional; Region: PRK05248 481805011364 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; Validated; Region: PRK09238 481805011365 Aconitase B swivel domain. Aconitate hydratase B is involved in energy metabolism as part of the TCA cycle. It catalyses the formation of cis-aconitate from citrate. This is the aconitase swivel domain, which undergoes swivelling conformational change in...; Region: AcnB_Swivel; cd01576 481805011366 substrate binding site [chemical binding]; other site 481805011367 Aconitate hydratase B catalyses the formation of cis-aconitate from citrate as part of the TCA cycle; Region: AcnB; cd01581 481805011368 substrate binding site [chemical binding]; other site 481805011369 ligand binding site [chemical binding]; other site 481805011370 Protein of unknown function (DUF3300); Region: DUF3300; pfam11737 481805011371 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 481805011372 Protein of unknown function (DUF3106); Region: DUF3106; pfam11304 481805011373 dihydrolipoamide dehydrogenase; Reviewed; Region: PRK06467 481805011374 NAD(P)-binding Rossmann-like domain; Region: NAD_binding_8; pfam13450 481805011375 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805011376 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 481805011377 pyruvate dehydrogenase dihydrolipoyltransacetylase; Validated; Region: aceF; PRK11854 481805011378 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 481805011379 E3 interaction surface; other site 481805011380 lipoyl attachment site [posttranslational modification]; other site 481805011381 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 481805011382 E3 interaction surface; other site 481805011383 lipoyl attachment site [posttranslational modification]; other site 481805011384 Lipoyl domain of the dihydrolipoyl acyltransferase component (E2) of 2-oxo acid dehydrogenases. 2-oxo acid dehydrogenase multienzyme complexes, like pyruvate dehydrogenase (PDH), 2-oxoglutarate dehydrogenase (OGDH) and branched-chain 2-oxo acid...; Region: lipoyl_domain; cd06849 481805011385 E3 interaction surface; other site 481805011386 lipoyl attachment site [posttranslational modification]; other site 481805011387 e3 binding domain; Region: E3_binding; pfam02817 481805011388 2-oxoacid dehydrogenases acyltransferase (catalytic domain); Region: 2-oxoacid_dh; pfam00198 481805011389 pyruvate dehydrogenase subunit E1; Reviewed; Region: aceE; PRK09405 481805011390 Thiamine pyrophosphate (TPP) family, E1 of E. coli PDC-like subfamily, TPP-binding module; composed of proteins similar to the E1 component of the Escherichia coli pyruvate dehydrogenase multienzyme complex (PDC). PDC catalyzes the oxidative...; Region: TPP_E1_EcPDC_like; cd02017 481805011391 dimer interface [polypeptide binding]; other site 481805011392 TPP-binding site [chemical binding]; other site 481805011393 Transcriptional regulators [Transcription]; Region: FadR; COG2186 481805011394 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805011395 DNA-binding site [nucleotide binding]; DNA binding site 481805011396 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 481805011397 aromatic amino acid transporter; Provisional; Region: PRK10238 481805011398 regulatory protein AmpE; Provisional; Region: PRK10987 481805011399 N-acetyl-anhydromuramyl-L-alanine amidase [Cell envelope biogenesis, outer membrane]; Region: ampD; COG3023 481805011400 Peptidoglycan recognition proteins (PGRPs) are pattern recognition receptors that bind, and in certain cases, hydrolyze peptidoglycans (PGNs) of bacterial cell walls. PGRPs have been divided into three classes: short PGRPs (PGRP-S), that are small (20...; Region: PGRP; cd06583 481805011401 amidase catalytic site [active] 481805011402 Zn binding residues [ion binding]; other site 481805011403 substrate binding site [chemical binding]; other site 481805011404 quinolinate phosphoribosyltransferase; Validated; Region: PRK09016 481805011405 Quinolinate phosphoribosyl transferase (QAPRTase or QPRTase), also called nicotinate-nucleotide pyrophosphorylase, is involved in the de novo synthesis of NAD in both prokaryotes and eukaryotes. It catalyses the reaction of quinolinic acid (QA) with...; Region: QPRTase; cd01572 481805011406 dimerization interface [polypeptide binding]; other site 481805011407 active site 481805011408 putative major pilin subunit; Provisional; Region: PRK10574 481805011409 Type IV pilin N-term methylation site GFxxxE; Region: N_methyl_2; pfam13544 481805011410 Pilin (bacterial filament); Region: Pilin; pfam00114 481805011411 hypothetical protein; Provisional; Region: PRK10436 481805011412 PulE/GspE The type II secretory pathway is the main terminal branch of the general secretory pathway (GSP). It is responsible for the export the majority of Gram-negative bacterial exoenzymes and toxins. PulE is a cytoplasmic protein of the GSP, which...; Region: PulE-GspE; cd01129 481805011413 Walker A motif; other site 481805011414 ATP binding site [chemical binding]; other site 481805011415 Walker B motif; other site 481805011416 type IV pilin biogenesis protein; Provisional; Region: PRK10573 481805011417 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 481805011418 Type II secretion system (T2SS), protein F; Region: T2SF; pfam00482 481805011419 guanosine 5'-monophosphate oxidoreductase; Provisional; Region: PRK05096 481805011420 IMPDH: The catalytic domain of the inosine monophosphate dehydrogenase. IMPDH catalyzes the NAD-dependent oxidation of inosine 5'-monophosphate (IMP) to xanthosine 5' monophosphate (XMP). It is a rate-limiting step in the de novo synthesis of...; Region: IMPDH; cd00381 481805011421 active site 481805011422 Dephospho-CoA kinase [Coenzyme metabolism]; Region: CoaE; COG0237 481805011423 Dephospho-coenzyme A kinase (DPCK, EC 2.7.1.24) catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA, which is the final step in CoA biosynthesis; Region: DPCK; cd02022 481805011424 CoA-binding site [chemical binding]; other site 481805011425 ATP-binding [chemical binding]; other site 481805011426 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4582 481805011427 DNA gyrase inhibitor; Reviewed; Region: PRK00418 481805011428 The MutT pyrophosphohydrolase is a prototypical Nudix hydrolase that catalyzes the hydrolysis of nucleoside and deoxynucleoside triphosphates (NTPs and dNTPs) by substitution at a beta-phosphorus to yield a nucleotide monophosphate (NMP) and inorganic...; Region: MutT_pyrophosphohydrolase; cd03425 481805011429 active site 481805011430 8-oxo-dGMP binding site [chemical binding]; other site 481805011431 nudix motif; other site 481805011432 metal binding site [ion binding]; metal-binding site 481805011433 preprotein translocase subunit SecA; Reviewed; Region: PRK12904 481805011434 SecA preprotein cross-linking domain; Region: SecA_PP_bind; smart00958 481805011435 SEC-C motif; Region: SEC-C; pfam02810 481805011436 SecA regulator SecM; Provisional; Region: PRK02943 481805011437 UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase; Reviewed; Region: lpxC; PRK13186 481805011438 UDP-3-O-acyl N-acetylglycosamine deacetylase; Region: LpxC; pfam03331 481805011439 cell division protein FtsZ; Validated; Region: PRK09330 481805011440 FtsZ is a GTPase that is similar to the eukaryotic tubulins and is essential for cell division in prokaryotes. FtsZ is capable of polymerizing in a GTP-driven process into structures similar to those formed by tubulin. FtsZ forms a ring-shaped septum at...; Region: FtsZ_type1; cd02201 481805011441 nucleotide binding site [chemical binding]; other site 481805011442 SulA interaction site; other site 481805011443 cell division protein FtsA; Reviewed; Region: ftsA; PRK09472 481805011444 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481805011445 Cell division protein FtsA; Region: FtsA; pfam14450 481805011446 cell division protein FtsQ; Provisional; Region: PRK10775 481805011447 POTRA domain, FtsQ-type; Region: POTRA_1; pfam08478 481805011448 Cell division protein FtsQ; Region: FtsQ; pfam03799 481805011449 D-alanine--D-alanine ligase; Reviewed; Region: ddl; PRK01372 481805011450 D-ala D-ala ligase N-terminus; Region: Dala_Dala_lig_N; pfam01820 481805011451 D-ala D-ala ligase C-terminus; Region: Dala_Dala_lig_C; pfam07478 481805011452 UDP-N-acetylmuramate--L-alanine ligase; Provisional; Region: murC; PRK00421 481805011453 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 481805011454 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 481805011455 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 481805011456 undecaprenyldiphospho-muramoylpentapeptide beta-N- acetylglucosaminyltransferase; Provisional; Region: murG; PRK00726 481805011457 MurG is an N-acetylglucosaminyltransferase, the last enzyme involved in the intracellular phase of peptidoglycan biosynthesis. It transfers N-acetyl-D-glucosamine (GlcNAc) from UDP-GlcNAc to the C4 hydroxyl of a lipid-linked N-acetylmuramoyl pentapeptide...; Region: GT1_MurG; cd03785 481805011458 active site 481805011459 homodimer interface [polypeptide binding]; other site 481805011460 cell division protein FtsW; Provisional; Region: PRK10774 481805011461 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional; Region: murD; PRK03806 481805011462 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 481805011463 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 481805011464 phospho-N-acetylmuramoyl-pentapeptide-transferase; Provisional; Region: mraY; PRK00108 481805011465 Phospho-N-acetylmuramoyl-pentapeptide-transferase (mraY) is an enzyme responsible for the formation of the first lipid intermediate in the synthesis of bacterial cell wall peptidoglycan. It catalyzes the formation of...; Region: GT_MraY; cd06852 481805011466 Mg++ binding site [ion binding]; other site 481805011467 putative catalytic motif [active] 481805011468 putative substrate binding site [chemical binding]; other site 481805011469 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase; Reviewed; Region: murF; PRK10773 481805011470 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 481805011471 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 481805011472 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 481805011473 UDP-N-acetylmuramoylalanyl-D-glutamate--2, 6-diaminopimelate ligase; Provisional; Region: murE; PRK00139 481805011474 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 481805011475 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 481805011476 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 481805011477 peptidoglycan synthase FtsI; Provisional; Region: PRK15105 481805011478 Penicillin-binding Protein dimerisation domain; Region: PBP_dimer; pfam03717 481805011479 Penicillin binding protein transpeptidase domain; Region: Transpeptidase; pfam00905 481805011480 cell division protein FtsL; Provisional; Region: PRK10772 481805011481 16S rRNA (cytosine(1402)-N(4))-methyltransferase; Region: TIGR00006 481805011482 16S rRNA m(4)C1402 methyltranserfase; Provisional; Region: PRK00050 481805011483 mraZ protein; Region: TIGR00242 481805011484 MraZ protein; Region: MraZ; pfam02381 481805011485 MraZ protein; Region: MraZ; pfam02381 481805011486 DNA-binding transcriptional regulator FruR; Provisional; Region: PRK11303 481805011487 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481805011488 DNA binding site [nucleotide binding] 481805011489 domain linker motif; other site 481805011490 Ligand binding domain of DNA transcription repressor specific for fructose (FruR) and its close homologs; Region: PBP1_FruR; cd06274 481805011491 dimerization interface [polypeptide binding]; other site 481805011492 ligand binding site [chemical binding]; other site 481805011493 similar to FruR leader peptide; KEGG: sdy:SDY_0109 FruR leader peptide 481805011494 acetolactate synthase 3 regulatory subunit; Reviewed; Region: ilvH; PRK11895 481805011495 N-terminal ACT domain of the Escherichia coli IlvH-like regulatory subunit of acetohydroxyacid synthase (AHAS); Region: ACT_AHAS; cd04878 481805011496 putative valine binding site [chemical binding]; other site 481805011497 dimer interface [polypeptide binding]; other site 481805011498 Small subunit of acetolactate synthase; Region: ALS_ss_C; pfam10369 481805011499 acetolactate synthase 3 catalytic subunit; Validated; Region: PRK07979 481805011500 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 481805011501 PYR/PP interface [polypeptide binding]; other site 481805011502 dimer interface [polypeptide binding]; other site 481805011503 TPP binding site [chemical binding]; other site 481805011504 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 481805011505 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 481805011506 TPP-binding site [chemical binding]; other site 481805011507 dimer interface [polypeptide binding]; other site 481805011508 leucine transcriptional activator; Reviewed; Region: leuO; PRK09508 481805011509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805011510 The C-terminal substrate binding domain of LysR-type transcriptional regulator LeuO, an activator of leucine synthesis operon, contains the type 2 periplasmic binding fold; Region: PBP2_LeuO; cd08466 481805011511 putative substrate binding pocket [chemical binding]; other site 481805011512 putative dimerization interface [polypeptide binding]; other site 481805011513 leu operon leader peptide; Provisional; Region: PRK09925 481805011514 2-isopropylmalate synthase; Validated; Region: PRK00915 481805011515 2-isopropylmalate synthase (IPMS), N-terminal catalytic TIM barrel domain; Region: DRE_TIM_IPMS; cd07940 481805011516 active site 481805011517 catalytic residues [active] 481805011518 metal binding site [ion binding]; metal-binding site 481805011519 LeuA allosteric (dimerisation) domain; Region: LeuA_dimer; pfam08502 481805011520 3-isopropylmalate dehydrogenase; Provisional; Region: PRK00772 481805011521 tartrate dehydrogenase; Region: TTC; TIGR02089 481805011522 3-isopropylmalate dehydratase large subunit; Reviewed; Region: PRK00402 481805011523 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate; Region: IPMI; cd01583 481805011524 substrate binding site [chemical binding]; other site 481805011525 ligand binding site [chemical binding]; other site 481805011526 isopropylmalate isomerase small subunit; Provisional; Region: leuD; PRK01641 481805011527 Aconatase-like swivel domain of 3-isopropylmalate dehydratase and related uncharacterized proteins. 3-isopropylmalate dehydratase catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate...; Region: IPMI_Swivel; cd01577 481805011528 substrate binding site [chemical binding]; other site 481805011529 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805011530 sugar efflux transporter; Region: 2A0120; TIGR00899 481805011531 putative substrate translocation pore; other site 481805011532 transcriptional regulator SgrR; Provisional; Region: PRK13626 481805011533 Sugar transport-related sRNA regulator N-term; Region: SgrR_N; pfam12793 481805011534 The C-terminal solute-binding domain of DNA-binding transcriptional regulator SgrR is related to the ABC-type oligopeptide-binding proteins and contains the type 2 periplasmic-binding fold; Region: PBP2_SgrR_like; cd08507 481805011535 thiamine transporter substrate binding subunit; Provisional; Region: tbpA; PRK11205 481805011536 ABC-type thiamine transport system, periplasmic component [Coenzyme metabolism]; Region: TbpA; COG4143 481805011537 thiamine transporter membrane protein; Reviewed; Region: thiP; PRK09433 481805011538 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805011539 dimer interface [polypeptide binding]; other site 481805011540 conserved gate region; other site 481805011541 putative PBP binding loops; other site 481805011542 ABC-ATPase subunit interface; other site 481805011543 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805011544 dimer interface [polypeptide binding]; other site 481805011545 conserved gate region; other site 481805011546 putative PBP binding loops; other site 481805011547 ABC-ATPase subunit interface; other site 481805011548 thiamine transporter ATP-binding subunit; Provisional; Region: thiQ; PRK10771 481805011549 ATP-binding cassette domain of the thiamine transport system; Region: ABC_ThiQ_thiamine_transporter; cd03298 481805011550 Walker A/P-loop; other site 481805011551 ATP binding site [chemical binding]; other site 481805011552 Q-loop/lid; other site 481805011553 ABC transporter signature motif; other site 481805011554 Walker B; other site 481805011555 D-loop; other site 481805011556 H-loop/switch region; other site 481805011557 Uncharacterized membrane-associated protein [Function unknown]; Region: DedA; COG0586 481805011558 SNARE associated Golgi protein; Region: SNARE_assoc; pfam09335 481805011559 DNA-binding transcriptional regulator AraC; Provisional; Region: PRK10572 481805011560 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481805011561 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805011562 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805011563 ribulokinase; Provisional; Region: PRK04123 481805011564 Ribulokinases; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_RBK; cd07781 481805011565 N- and C-terminal domain interface [polypeptide binding]; other site 481805011566 active site 481805011567 MgATP binding site [chemical binding]; other site 481805011568 catalytic site [active] 481805011569 metal binding site [ion binding]; metal-binding site 481805011570 carbohydrate binding site [chemical binding]; other site 481805011571 homodimer interface [polypeptide binding]; other site 481805011572 L-arabinose isomerase; Provisional; Region: PRK02929 481805011573 L-Arabinose isomerase (AI) catalyzes the isomerization of L-arabinose to L-ribulose, the first reaction in its conversion into D-xylulose-5-phosphate, an intermediate in the pentose phosphate pathway, which allows L-arabinose to be used as a carbon...; Region: L-arabinose_isomerase; cd03557 481805011574 putative hexamer (dimer of trimers) interface [polypeptide binding]; other site 481805011575 trimer interface [polypeptide binding]; other site 481805011576 putative substrate binding site [chemical binding]; other site 481805011577 putative metal binding site [ion binding]; other site 481805011578 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 481805011579 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 481805011580 intersubunit interface [polypeptide binding]; other site 481805011581 active site 481805011582 Zn2+ binding site [ion binding]; other site 481805011583 DNA polymerase II; Reviewed; Region: PRK05762 481805011584 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase II and similar bacterial family-B DNA polymerases; Region: DNA_polB_II_exo; cd05784 481805011585 active site 481805011586 catalytic site [active] 481805011587 substrate binding site [chemical binding]; other site 481805011588 DNA polymerase type-II subfamily catalytic domain. Bacteria contain five DNA polymerases (I, II, III, IV and V). DNA polymerase II (Pol II) is a prototype for the B-family of polymerases. The role of Pol II in a variety of cellular activities, such as...; Region: POLBc_Pol_II; cd05537 481805011589 active site 481805011590 metal-binding site 481805011591 ATP-dependent helicase HepA; Validated; Region: PRK04914 481805011592 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481805011593 ATP binding site [chemical binding]; other site 481805011594 putative Mg++ binding site [ion binding]; other site 481805011595 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805011596 nucleotide binding region [chemical binding]; other site 481805011597 ATP-binding site [chemical binding]; other site 481805011598 Pseudouridylate synthases, 23S RNA-specific [Translation, ribosomal structure and biogenesis]; Region: RluA; COG0564 481805011599 Pseudouridine synthase, RsuA/RluD family; Region: PseudoU_synth_RluCD_like; cd02869 481805011600 active site 481805011601 Dna-J like membrane chaperone protein; Provisional; Region: djlA; PRK09430 481805011602 N-terminal tellurium resistance protein terB-like domain of heat shock DnaJ-like proteins; Region: terB_like_DjlA; cd07316 481805011603 putative metal binding site [ion binding]; other site 481805011604 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 481805011605 HSP70 interaction site [polypeptide binding]; other site 481805011606 LPS assembly outer membrane complex protein LptD; Provisional; Region: PRK03761 481805011607 OstA-like protein; Region: OstA; pfam03968 481805011608 Organic solvent tolerance protein; Region: OstA_C; pfam04453 481805011609 peptidyl-prolyl cis-trans isomerase SurA; Provisional; Region: PRK10770 481805011610 SurA N-terminal domain; Region: SurA_N; pfam09312 481805011611 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 481805011612 PPIC-type PPIASE domain; Region: Rotamase; pfam00639 481805011613 4-hydroxythreonine-4-phosphate dehydrogenase; Reviewed; Region: pdxA; PRK00232 481805011614 4-hydroxythreonine-4-phosphate dehydrogenase; Validated; Region: pdxA; PRK03743 481805011615 16S ribosomal RNA methyltransferase KsgA/Dim1 family protein; Reviewed; Region: ksgA; PRK00274 481805011616 Dimethyladenosine transferase (rRNA methylation) [Translation, ribosomal structure and biogenesis]; Region: KsgA; COG0030 481805011617 CO2+/MG2+ efflux protein ApaG; Reviewed; Region: apaG; PRK05461 481805011618 bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Region: apaH; TIGR00668 481805011619 Escherichia coli ApaH and related proteins, metallophosphatase domain; Region: MPP_ApaH; cd07422 481805011620 active site 481805011621 metal binding site [ion binding]; metal-binding site 481805011622 Dihydrofolate reductase [Coenzyme metabolism]; Region: FolA; COG0262 481805011623 Dihydrofolate reductase (DHFR). Reduces 7,8-dihydrofolate to 5,6,7,8-tetrahydrofolate with NADPH as a cofactor. This is an essential step in the biosynthesis of deoxythymidine phosphate since 5,6,7,8-tetrahydrofolate is required to regenerate 5; Region: DHFR; cd00209 481805011624 folate binding site [chemical binding]; other site 481805011625 NADP+ binding site [chemical binding]; other site 481805011626 glutathione-regulated potassium-efflux system protein KefC; Provisional; Region: PRK03562 481805011627 transporter, monovalent cation:proton antiporter-2 (CPA2) family; Region: 2a37; TIGR00932 481805011628 TrkA-N domain; Region: TrkA_N; pfam02254 481805011629 glutathione-regulated potassium-efflux system ancillary protein KefF; Provisional; Region: PRK00871 481805011630 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805011631 Sugar (and other) transporter; Region: Sugar_tr; pfam00083 481805011632 putative substrate translocation pore; other site 481805011633 ferredoxin-like protein FixX; Provisional; Region: PRK15449 481805011634 putative oxidoreductase FixC; Provisional; Region: PRK10157 481805011635 putative electron transfer flavoprotein FixB; Provisional; Region: fixB; PRK03363 481805011636 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF; cd01985 481805011637 Ligand binding site [chemical binding]; other site 481805011638 Electron transfer flavoprotein FAD-binding domain; Region: ETF_alpha; pfam00766 481805011639 The electron transfer flavoprotein (ETF) serves as a specific electron acceptor for various mitochondrial dehydrogenases. ETF transfers electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase. ETF is an heterodimer that consists of an...; Region: ETF_beta; cd01714 481805011640 Ligand binding site [chemical binding]; other site 481805011641 Electron transfer flavoprotein domain; Region: ETF; pfam01012 481805011642 L-carnitine/gamma-butyrobetaine antiporter; Provisional; Region: PRK03356 481805011643 crotonobetainyl-CoA dehydrogenase; Validated; Region: PRK03354 481805011644 Acyl-CoA dehydrogenase; Region: ACAD; cd00567 481805011645 active site 481805011646 crotonobetainyl-CoA:carnitine CoA-transferase; Provisional; Region: PRK03525 481805011647 CoA-transferase family III; Region: CoA_transf_3; pfam02515 481805011648 putative crotonobetaine/carnitine-CoA ligase; Validated; Region: caiC; PRK08008 481805011649 Uncharacterized subfamily of fatty acid CoA ligase (FACL); Region: FACL_DitJ_like; cd05934 481805011650 acyl-activating enzyme (AAE) consensus motif; other site 481805011651 putative AMP binding site [chemical binding]; other site 481805011652 putative active site [active] 481805011653 putative CoA binding site [chemical binding]; other site 481805011654 carnitinyl-CoA dehydratase; Provisional; Region: PRK03580 481805011655 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 481805011656 substrate binding site [chemical binding]; other site 481805011657 oxyanion hole (OAH) forming residues; other site 481805011658 trimer interface [polypeptide binding]; other site 481805011659 carnitine operon protein CaiE; Provisional; Region: PRK13627 481805011660 paaY-like: This group is composed by uncharacterized proteins with similarity to the protein product of the E. coli paaY gene, which is part of the paa gene cluster responsible for phenylacetic acid degradation. Proteins in this group are expected to...; Region: LbH_paaY_like; cd04745 481805011661 putative trimer interface [polypeptide binding]; other site 481805011662 putative metal binding site [ion binding]; other site 481805011663 DNA-binding transcriptional activator CaiF; Provisional; Region: PRK11476 481805011664 carbamoyl phosphate synthase large subunit; Reviewed; Region: carB; PRK05294 481805011665 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 481805011666 Carbamoyl-phosphate synthase L chain, ATP binding domain; Region: CPSase_L_D2; pfam02786 481805011667 Carbamoyl-phosphate synthetase large chain, oligomerisation domain; Region: CPSase_L_D3; pfam02787 481805011668 Carbamoyl-phosphate synthase L chain, N-terminal domain; Region: CPSase_L_chain; pfam00289 481805011669 ATP-grasp domain; Region: ATP-grasp_4; cl17255 481805011670 Methylglyoxal synthase-like domain from type II glutamine-dependent carbamoyl phosphate synthetase (CSP). CSP, a CarA and CarB heterodimer, catalyzes the production of carbamoyl phosphate which is subsequently employed in the metabolic pathways...; Region: MGS_CPS_II; cd01424 481805011671 IMP binding site; other site 481805011672 dimer interface [polypeptide binding]; other site 481805011673 interdomain contacts; other site 481805011674 partial ornithine binding site; other site 481805011675 carbamoyl phosphate synthase small subunit; Reviewed; Region: PRK12564 481805011676 Carbamoyl-phosphate synthase small chain, CPSase domain; Region: CPSase_sm_chain; smart01097 481805011677 Small chain of the glutamine-dependent form of carbamoyl phosphate synthase, CPSase II; Region: GATase1_CPSase; cd01744 481805011678 catalytic site [active] 481805011679 subunit interface [polypeptide binding]; other site 481805011680 Dihydrodipicolinate reductase [Amino acid transport and metabolism]; Region: DapB; COG0289 481805011681 Dihydrodipicolinate reductase, N-terminus; Region: DapB_N; pfam01113 481805011682 Dihydrodipicolinate reductase, C-terminus; Region: DapB_C; pfam05173 481805011683 4-hydroxy-3-methylbut-2-enyl diphosphate reductase; Reviewed; Region: ispH; PRK01045 481805011684 4-Hydroxy-3-methylbut-2-enyl diphosphate reductase IspH [Lipid metabolism]; Region: lytB; COG0761 481805011685 FKBP-type peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK15095 481805011686 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 481805011687 lipoprotein signal peptidase; Reviewed; Region: lspA; PRK00376 481805011688 isoleucyl-tRNA synthetase; Reviewed; Region: ileS; PRK05743 481805011689 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 481805011690 HIGH motif; other site 481805011691 catalytic core domain of isoleucyl-tRNA synthetases; Region: IleRS_core; cd00818 481805011692 active site 481805011693 KMSKS motif; other site 481805011694 Anticodon-binding domain of bacterial and eukaryotic mitochondrial isoleucyl tRNA synthetases; Region: Anticodon_Ia_Ile_BEm; cd07960 481805011695 tRNA binding surface [nucleotide binding]; other site 481805011696 anticodon binding site; other site 481805011697 Zinc finger found in FPG and IleRS; Region: zf-FPG_IleRS; pfam06827 481805011698 bifunctional riboflavin kinase/FMN adenylyltransferase; Reviewed; Region: PRK05627 481805011699 FAD synthetase, N-terminal domain of the bifunctional enzyme; Region: FAD_synthetase_N; cd02064 481805011700 active site 481805011701 Riboflavin kinase; Region: Flavokinase; smart00904 481805011702 30S ribosomal protein S20; Reviewed; Region: rpsT; PRK00239 481805011703 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805011704 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805011705 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805011706 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805011707 transcriptional activator NhaR; Provisional; Region: nhaR; PRK11062 481805011708 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805011709 The C-terminal substrate binding domain of LysR-type transcriptional activator of the nhaA gene, encoding Na+/H+ antiporter, contains the type 2 periplasmic binding fold; Region: PBP2_NhaR; cd08429 481805011710 putative dimerization interface [polypeptide binding]; other site 481805011711 pH-dependent sodium/proton antiporter; Reviewed; Region: nhaA; PRK09561 481805011712 Hok/gef family; Region: HOK_GEF; pfam01848 481805011713 Transposase DDE domain; Region: DDE_Tnp_1; pfam01609 481805011714 FOG: Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3385 481805011715 chaperone protein DnaJ; Provisional; Region: PRK10767 481805011716 DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s; Region: DnaJ; cd06257 481805011717 HSP70 interaction site [polypeptide binding]; other site 481805011718 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cl03262 481805011719 substrate binding site [polypeptide binding]; other site 481805011720 Zinc finger domain of DnaJ and HSP40; Region: DnaJ_zf; cd10719 481805011721 Zn binding sites [ion binding]; other site 481805011722 C-terminal substrate binding domain of DnaJ and HSP40; Region: DnaJ_C; cd10747 481805011723 dimer interface [polypeptide binding]; other site 481805011724 molecular chaperone DnaK; Provisional; Region: dnaK; PRK00290 481805011725 Nucleotide-binding domain of human HSPA9, Escherichia coli DnaK, and similar proteins; Region: HSPA9-like_NBD; cd11733 481805011726 nucleotide binding site [chemical binding]; other site 481805011727 NEF interaction site [polypeptide binding]; other site 481805011728 SBD interface [polypeptide binding]; other site 481805011729 hypothetical protein; Provisional; Region: PRK10154 481805011730 hypothetical protein; Provisional; Region: PRK10236 481805011731 Domain of unknown function (DUF3944); Region: DUF3944; pfam13099 481805011732 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG4735 481805011733 hypothetical protein; Provisional; Region: PRK10659 481805011734 MogA_MoaB family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF) an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea; Region: MogA_MoaB; cd00886 481805011735 MPT binding site; other site 481805011736 trimer interface [polypeptide binding]; other site 481805011737 transaldolase-like protein; Provisional; Region: PTZ00411 481805011738 Transaldolases including both TalA and TalB; Region: Transaldolase_TalAB; cd00957 481805011739 active site 481805011740 dimer interface [polypeptide binding]; other site 481805011741 catalytic residue [active] 481805011742 Na+/alanine symporter [Amino acid transport and metabolism]; Region: AlsT; COG1115 481805011743 Sodium:alanine symporter family; Region: Na_Ala_symp; pfam01235 481805011744 hypothetical protein; Validated; Region: PRK02101 481805011745 Protein of unknown function (DUF2502); Region: DUF2502; pfam10697 481805011746 Threonine synthase [Amino acid transport and metabolism]; Region: ThrC; COG0498 481805011747 Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threonine and inorganic phosphate is pyridoxal 5'-phosphate dependent. The Thr-synth_1 CD includes members from higher plants; Region: Thr-synth_2; cd01560 481805011748 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805011749 catalytic residue [active] 481805011750 homoserine kinase; Region: thrB; TIGR00191 481805011751 Protein of unknown function; Region: YhfT; pfam10797 481805011752 GHMP kinases N terminal domain; Region: GHMP_kinases_N; pfam00288 481805011753 bifunctional aspartokinase I/homoserine dehydrogenase I; Provisional; Region: thrA; PRK09436 481805011754 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 481805011755 putative catalytic residues [active] 481805011756 putative nucleotide binding site [chemical binding]; other site 481805011757 putative aspartate binding site [chemical binding]; other site 481805011758 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA-like_1; cd04921 481805011759 dimer interface [polypeptide binding]; other site 481805011760 putative threonine allosteric regulatory site; other site 481805011761 ACT domains of the bifunctional enzyme aspartokinase (AK) - homoserine dehydrogenase (HSDH); Region: ACT_AKi-HSDH-ThrA_2; cd04922 481805011762 putative threonine allosteric regulatory site; other site 481805011763 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 481805011764 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 481805011765 putative RNA methyltransferase; Provisional; Region: PRK10433 481805011766 RNA methyltransferase, TrmH family, group 1; Region: rRNA_methyl_1; TIGR00050 481805011767 two-component response regulator; Provisional; Region: PRK11173 481805011768 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805011769 active site 481805011770 phosphorylation site [posttranslational modification] 481805011771 intermolecular recognition site; other site 481805011772 dimerization interface [polypeptide binding]; other site 481805011773 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805011774 DNA binding site [nucleotide binding] 481805011775 Inner membrane protein involved in colicin E2 resistance [Defense mechanisms]; Region: CreD; COG4452 481805011776 sensory histidine kinase CreC; Provisional; Region: PRK11100 481805011777 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805011778 dimerization interface [polypeptide binding]; other site 481805011779 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805011780 dimer interface [polypeptide binding]; other site 481805011781 phosphorylation site [posttranslational modification] 481805011782 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805011783 ATP binding site [chemical binding]; other site 481805011784 Mg2+ binding site [ion binding]; other site 481805011785 G-X-G motif; other site 481805011786 DNA-binding response regulator CreB; Provisional; Region: PRK11083 481805011787 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805011788 active site 481805011789 phosphorylation site [posttranslational modification] 481805011790 intermolecular recognition site; other site 481805011791 dimerization interface [polypeptide binding]; other site 481805011792 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805011793 DNA binding site [nucleotide binding] 481805011794 hypothetical protein; Provisional; Region: PRK10756 481805011795 CreA protein; Region: CreA; pfam05981 481805011796 right oriC-binding transcriptional activator; Provisional; Region: PRK15121 481805011797 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805011798 GyrI-like small molecule binding domain; Region: GyrI-like; pfam06445 481805011799 Histidine phosphatase domain found in phosphoglycerate mutases and related proteins, mostly phosphatases; contains a His residue which is phosphorylated during the reaction; Region: HP_PGM_like; cd07067 481805011800 catalytic core [active] 481805011801 inosine/xanthosine triphosphatase; Reviewed; Region: PRK05074 481805011802 Trp operon repressor; Provisional; Region: PRK01381 481805011803 lytic murein transglycosylase; Provisional; Region: PRK11619 481805011804 Lytic Transglycosylase (LT) and Goose Egg White Lysozyme (GEWL) domain. Members include the soluble and insoluble membrane-bound LTs in bacteria, the LTs in bacteriophage lambda, as well as, the eukaryotic "goose-type" lysozymes (GEWL). LTs...; Region: LT_GEWL; cd00254 481805011805 N-acetyl-D-glucosamine binding site [chemical binding]; other site 481805011806 catalytic residue [active] 481805011807 putative ABC transporter ATP-binding protein; Reviewed; Region: PRK11819 481805011808 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805011809 Walker A/P-loop; other site 481805011810 ATP binding site [chemical binding]; other site 481805011811 Q-loop/lid; other site 481805011812 ABC transporter signature motif; other site 481805011813 Walker B; other site 481805011814 D-loop; other site 481805011815 H-loop/switch region; other site 481805011816 ABC transporter; Region: ABC_tran_2; pfam12848 481805011817 ATP-binding cassette domain of elongation factor 3, subfamily F; Region: ABCF_EF-3; cd03221 481805011818 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805011819 non-specific DNA binding site [nucleotide binding]; other site 481805011820 salt bridge; other site 481805011821 bifunctional DNA-binding transcriptional repressor/ NMN adenylyltransferase; Provisional; Region: PRK08099 481805011822 sequence-specific DNA binding site [nucleotide binding]; other site 481805011823 Nicotinamide/nicotinate mononucleotide adenylyltransferase of bifunctional NadR-like proteins; Region: NMNAT_NadR; cd02167 481805011824 active site 481805011825 (T/H)XGH motif; other site 481805011826 Predicted ATPase/kinase involved in NAD metabolism [Coenzyme metabolism]; Region: NadR; COG3172 481805011827 DNA repair protein RadA; Region: sms; TIGR00416 481805011828 Sms (bacterial radA) DNA repair protein. This protein is not related to archael radA any more than is to other RecA-like NTPases. Sms has a role in recombination and recombinational repair and is responsible for the stabilization or processing of...; Region: Sms; cd01121 481805011829 Walker A motif/ATP binding site; other site 481805011830 ATP binding site [chemical binding]; other site 481805011831 Walker B motif; other site 481805011832 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 481805011833 phosphoserine phosphatase; Provisional; Region: serB; PRK11133 481805011834 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805011835 motif II; other site 481805011836 hypothetical protein; Provisional; Region: PRK11246 481805011837 lipoate-protein ligase A; Provisional; Region: lplA; PRK03822 481805011838 Lipoate-protein ligase A [Coenzyme metabolism]; Region: LplA; COG0095 481805011839 Bacterial lipoate protein ligase C-terminus; Region: Lip_prot_lig_C; pfam10437 481805011840 Helix-turn-helix XRE-family like proteins. Prokaryotic DNA binding proteins belonging to the xenobiotic response element family of transcriptional regulators; Region: HTH_XRE; cd00093 481805011841 non-specific DNA binding site [nucleotide binding]; other site 481805011842 salt bridge; other site 481805011843 sequence-specific DNA binding site [nucleotide binding]; other site 481805011844 purine nucleoside phosphorylase; Reviewed; Region: deoD; PRK05819 481805011845 Uridine phosphorylase [Nucleotide transport and metabolism]; Region: Udp; COG2820 481805011846 phosphopentomutase; Provisional; Region: PRK05362 481805011847 Metalloenzyme superfamily; Region: Metalloenzyme; pfam01676 481805011848 thymidine phosphorylase; Reviewed; Region: deoA; PRK05820 481805011849 Glycosyl transferase family, helical bundle domain; Region: Glycos_trans_3N; pfam02885 481805011850 Glycosyl transferase family, a/b domain; Region: Glycos_transf_3; pfam00591 481805011851 Pyrimidine nucleoside phosphorylase C-terminal domain; Region: PYNP_C; pfam07831 481805011852 2-deoxyribose-5-phosphate aldolase (DERA) of the DeoC family; Region: DeoC; cd00959 481805011853 intersubunit interface [polypeptide binding]; other site 481805011854 active site 481805011855 catalytic residue [active] 481805011856 hypothetical protein; Provisional; Region: PRK10977 481805011857 glycine radical enzyme activase, YjjW family; Region: activase_YjjW; TIGR04041 481805011858 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805011859 FeS/SAM binding site; other site 481805011860 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 481805011861 active site 481805011862 Predicted esterase of the alpha-beta hydrolase superfamily [General function prediction only]; Region: COG4667 481805011863 Hypothetical patatin similar to yjju protein of Escherichia coli; Region: Pat_hypo_Ecoli_yjju_like; cd07208 481805011864 active site 481805011865 nucleophile elbow; other site 481805011866 periplasmic protein; Provisional; Region: PRK10568 481805011867 BON domain; Region: BON; pfam04972 481805011868 BON domain; Region: BON; pfam04972 481805011869 peptide chain release factor 3; Provisional; Region: prfC; PRK00741 481805011870 Release Factor 3 (RF3) protein involved in the terminal step of translocation in bacteria; Region: RF3; cd04169 481805011871 G1 box; other site 481805011872 putative GEF interaction site [polypeptide binding]; other site 481805011873 GTP/Mg2+ binding site [chemical binding]; other site 481805011874 Switch I region; other site 481805011875 G2 box; other site 481805011876 G3 box; other site 481805011877 Switch II region; other site 481805011878 G4 box; other site 481805011879 G5 box; other site 481805011880 RF3_II: this subfamily represents the domain II of bacterial Release Factor 3 (RF3). Termination of protein synthesis by the ribosome requires two release factor (RF) classes. The class II RF3 is a GTPase that removes class I RFs (RF1 or RF2) from the...; Region: RF3_II; cd03689 481805011881 dUMP phosphatase; Provisional; Region: PRK09449 481805011882 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805011883 motif II; other site 481805011884 ribosomal-protein-alanine N-acetyltransferase; Provisional; Region: rimI; PRK09491 481805011885 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481805011886 Coenzyme A binding pocket [chemical binding]; other site 481805011887 DNA polymerase III subunit psi; Validated; Region: PRK06856 481805011888 16S ribosomal RNA m2G1207 methyltransferase; Provisional; Region: rsmC; PRK09489 481805011889 Methyltransferase small domain N-terminal; Region: MTS_N; pfam08468 481805011890 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805011891 S-adenosylmethionine binding site [chemical binding]; other site 481805011892 Protein of unknown function (DUF1435); Region: DUF1435; pfam07256 481805011893 ferric iron reductase involved in ferric hydroximate transport; Provisional; Region: PRK10647 481805011894 Ferric iron reductase FhuF-like transporter; Region: FhuF; pfam06276 481805011895 FhuF 2Fe-2S C-terminal domain; Region: FhuF_C; pfam11575 481805011896 DNA-binding transcriptional activator BglJ; Provisional; Region: PRK11475 481805011897 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805011898 DNA binding residues [nucleotide binding] 481805011899 dimerization interface [polypeptide binding]; other site 481805011900 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain [Signal transduction mechanisms / Transcription]; Region: CitB; COG2197 481805011901 C-terminal DNA-binding domain of LuxR-like proteins. This domain contains a helix-turn-helix motif and binds DNA. Proteins belonging to this group are response regulators; some act as transcriptional activators, others as transcriptional repressors. Many...; Region: LuxR_C_like; cd06170 481805011902 DNA binding residues [nucleotide binding] 481805011903 dimerization interface [polypeptide binding]; other site 481805011904 Uncharacterized conserved protein [Function unknown]; Region: COG2966 481805011905 Protein of unknown function (DUF1212); Region: DUF1212; pfam06738 481805011906 hypothetical protein; Provisional; Region: PRK09917 481805011907 primosomal protein DnaI; Provisional; Region: PRK02854 481805011908 DNA replication protein DnaC; Validated; Region: PRK07952 481805011909 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805011910 Walker A motif; other site 481805011911 ATP binding site [chemical binding]; other site 481805011912 Walker B motif; other site 481805011913 hypothetical protein; Provisional; Region: PRK11667 481805011914 phosphoglycerol transferase I; Provisional; Region: PRK03776 481805011915 Phosphoglycerol transferase and related proteins, alkaline phosphatase superfamily [Cell envelope biogenesis, outer membrane]; Region: MdoB; COG1368 481805011916 Threonine dehydrogenase and related Zn-dependent dehydrogenases [Amino acid transport and metabolism / General function prediction only]; Region: Tdh; COG1063 481805011917 Alcohol dehydrogenases of the MDR family; Region: Zn_ADH7; cd08261 481805011918 putative NAD(P) binding site [chemical binding]; other site 481805011919 catalytic Zn binding site [ion binding]; other site 481805011920 structural Zn binding site [ion binding]; other site 481805011921 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805011922 DNA-binding site [nucleotide binding]; DNA binding site 481805011923 Transcriptional regulators [Transcription]; Region: GntR; COG1802 481805011924 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cl17414 481805011925 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 481805011926 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805011927 D-galactonate transporter; Region: 2A0114; TIGR00893 481805011928 putative substrate translocation pore; other site 481805011929 methyl-accepting chemotaxis protein I; Provisional; Region: PRK15041 481805011930 ligand binding domain of Tar- and Tsr-related chemoreceptors; Region: Tar_Tsr_LBD; cd00181 481805011931 dimer interface [polypeptide binding]; other site 481805011932 ligand binding site [chemical binding]; other site 481805011933 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805011934 dimerization interface [polypeptide binding]; other site 481805011935 Methyl-accepting chemotaxis protein (MCP), signaling domain; Region: MCP_signal; cd11386 481805011936 dimer interface [polypeptide binding]; other site 481805011937 putative CheW interface [polypeptide binding]; other site 481805011938 homoprotocatechuate degradation operon regulator, HpaR; Region: HpaR; TIGR02337 481805011939 helix_turn_helix multiple antibiotic resistance protein; Region: HTH_MARR; smart00347 481805011940 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase; Provisional; Region: PRK15203 481805011941 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, N-terminal subunit; Region: HpaG-N-term; TIGR02305 481805011942 Fumarylacetoacetate (FAA) hydrolase family; Region: FAA_hydrolase; pfam01557 481805011943 5-carboxymethyl-2-hydroxymuconate semialdehyde dehydrogenase; Region: HpaE; TIGR02299 481805011944 Human aldehyde dehydrogenase family 8 member A1-like; Region: ALDH_F8_HMSADH; cd07093 481805011945 NAD binding site [chemical binding]; other site 481805011946 catalytic residues [active] 481805011947 The Class III extradiol dioxygenase, homoprotocatechuate 2,3-dioxygenase, catalyzes the key ring cleavage step in the metabolism of homoprotocatechuate; Region: HPCD; cd07370 481805011948 Catalytic LigB subunit of aromatic ring-opening dioxygenase; Region: LigB; pfam02900 481805011949 putative active site [active] 481805011950 putative metal binding site [ion binding]; other site 481805011951 5-carboxymethyl-2-hydroxymuconate isomerase (CHMI) is a trimeric enzyme catalyzing the isomerization of the unsaturated ketone 5-(carboxymethyl)-2-hydroxymuconate to 5-(carboxymethyl)-2-oxo-3-hexene-1,6-dionate. This is one step in the...; Region: CHMI; cd00580 481805011952 putative substrate binding pocket [chemical binding]; other site 481805011953 trimer interface [polypeptide binding]; other site 481805011954 2-oxo-hepta-3-ene-1,7-dioic acid hydratase; Region: HpaH; TIGR02312 481805011955 HpcH/HpaI aldolase/citrate lyase family; Region: HpcH_HpaI; cl17231 481805011956 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805011957 4-hydroxyphenylacetate permease; Region: HpaX; TIGR02332 481805011958 putative substrate translocation pore; other site 481805011959 4-hydroxyphenylacetate catabolism regulatory protein HpaA; Region: HpaA; TIGR02297 481805011960 Cupin domain; Region: Cupin_2; pfam07883 481805011961 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805011962 4-hydroxyphenylacetate 3-monooxygenase, oxygenase component; Region: HpaB-2; TIGR02310 481805011963 4-hydroxyphenylacetate 3-hydroxylase C terminal; Region: HpaB; pfam03241 481805011964 4-hydroxyphenylacetate 3-monooxygenase reductase subunit; Provisional; Region: hpaC; PRK15486 481805011965 carbon starvation protein A; Provisional; Region: PRK15015 481805011966 Carbon starvation protein CstA; Region: CstA; pfam02554 481805011967 C-terminal domain on CstA (DUF4161); Region: DUF4161; pfam13722 481805011968 Uncharacterized small protein [Function unknown]; Region: COG2879 481805011969 putative GTP-binding protein YjiA; Provisional; Region: PRK11537 481805011970 The function of this protein family is unkown. The amino acid sequence of YjiA protein in E. coli contains several conserved motifs that characterizes it as a P-loop GTPase. YijA gene is among the genes significantly induced in response to DNA-damage...; Region: CobW_like; cd03112 481805011971 P-loop, Walker A motif; other site 481805011972 Base recognition motif; other site 481805011973 Cobalamin synthesis protein cobW C-terminal domain; Region: CobW_C; pfam07683 481805011974 Uncharacterized conserved protein [Function unknown]; Region: COG1479 481805011975 Protein of unknown function DUF262; Region: DUF262; pfam03235 481805011976 Protein of unknown function DUF262; Region: DUF262; pfam03235 481805011977 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 481805011978 putative transposase OrfB; Reviewed; Region: PHA02517 481805011979 HTH-like domain; Region: HTH_21; pfam13276 481805011980 Integrase core domain; Region: rve; pfam00665 481805011981 Integrase core domain; Region: rve_2; pfam13333 481805011982 Transposase; Region: HTH_Tnp_1; cl17663 481805011983 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 481805011984 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 481805011985 Type I restriction modification DNA specificity domain; Region: Methylase_S; pfam01420 481805011986 endoribonuclease SymE; Provisional; Region: PRK13605 481805011987 Uncharacterized conserved protein [Function unknown]; Region: COG1479 481805011988 Protein of unknown function DUF262; Region: DUF262; pfam03235 481805011989 Protein of unknown function DUF262; Region: DUF262; pfam03235 481805011990 Protein of unknown function (DUF1524); Region: DUF1524; pfam07510 481805011991 Uncharacterized conserved protein [Function unknown]; Region: COG3586 481805011992 Uncharacterized conserved small protein [Function unknown]; Region: COG5457 481805011993 Transcriptional regulators containing a DNA-binding HTH domain and an aminotransferase domain (MocR family) and their eukaryotic orthologs [Transcription / Amino acid transport and metabolism]; Region: ARO8; COG1167 481805011994 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805011995 DNA-binding site [nucleotide binding]; DNA binding site 481805011996 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481805011997 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805011998 homodimer interface [polypeptide binding]; other site 481805011999 catalytic residue [active] 481805012000 putative transposase; Provisional; Region: PRK09857 481805012001 Putative transposase, YhgA-like; Region: Transposase_31; pfam04754 481805012002 multidrug efflux system protein MdtM; Provisional; Region: PRK15403 481805012003 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805012004 putative substrate translocation pore; other site 481805012005 Predicted membrane protein [Function unknown]; Region: COG2733 481805012006 Uncharacterized conserved protein (DUF2164); Region: DUF2164; pfam09932 481805012007 Benzoyl-CoA reductase/2-hydroxyglutaryl-CoA dehydratase subunit, BcrC/BadD/HgdB [Amino acid transport and metabolism]; Region: HgdB; COG1775 481805012008 benzoyl-CoA reductase, subunit C; Region: benz_CoA_red_C; TIGR02263 481805012009 Activator of 2-hydroxyglutaryl-CoA dehydratase (HSP70-class ATPase domain) [Lipid metabolism]; Region: COG1924 481805012010 CoA-substrate-specific enzyme activase, putative; Region: CoA_E_activ; TIGR00241 481805012011 Protein of unknown function (DUF3343); Region: DUF3343; pfam11823 481805012012 SdiA-regulated; Region: SdiA-regulated; pfam06977 481805012013 SdiA-regulated; Region: SdiA-regulated; cd09971 481805012014 putative active site [active] 481805012015 Major Facilitator Superfamily; Region: MFS_1; pfam07690 481805012016 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805012017 putative substrate translocation pore; other site 481805012018 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3314 481805012019 Nucleoside recognition; Region: Gate; pfam07670 481805012020 hypothetical protein; Provisional; Region: PRK10519 481805012021 Isoaspartyl dipeptidase hydrolyzes the beta-L-isoaspartyl linkages in dipeptides, as part of the degradative pathway to eliminate proteins with beta-L-isoaspartyl peptide bonds, bonds whereby the beta-group of an aspartate forms the peptide link with the...; Region: Isoaspartyl-dipeptidase; cd01308 481805012022 isoaspartyl dipeptidase IadA; Region: isoAsp_dipep; TIGR01975 481805012023 dimer interface [polypeptide binding]; other site 481805012024 active site 481805012025 cell density-dependent motility repressor; Provisional; Region: PRK10082 481805012026 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805012027 The substrate binding domain of LysR-type transcriptional regulators (LTTRs), a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_LTTR_substrate; cd05466 481805012028 DNA replication/recombination/repair protein; Provisional; Region: iraD; PRK14128 481805012029 Protein of unknown function (DUF2686); Region: DUF2686; pfam10887 481805012030 DNA-binding transcriptional repressor UxuR; Provisional; Region: PRK10225 481805012031 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805012032 DNA-binding site [nucleotide binding]; DNA binding site 481805012033 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 481805012034 Mannitol dehydrogenase C-terminal domain; Region: Mannitol_dh_C; pfam08125 481805012035 mannonate dehydratase; Provisional; Region: PRK03906 481805012036 mannonate dehydratase; Region: uxuA; TIGR00695 481805012037 Mannose binding domain of FimH and related proteins; Region: FimH_man-bind; cd10466 481805012038 mannosyl binding site [chemical binding]; other site 481805012039 Fimbrial protein; Region: Fimbrial; pfam00419 481805012040 Transposase; Region: HTH_Tnp_1; cl17663 481805012041 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG2963 481805012042 putative transposase OrfB; Reviewed; Region: PHA02517 481805012043 HTH-like domain; Region: HTH_21; pfam13276 481805012044 Integrase core domain; Region: rve; pfam00665 481805012045 Integrase core domain; Region: rve_2; pfam13333 481805012046 Zn-dependent alcohol dehydrogenases [General function prediction only]; Region: AdhP; COG1064 481805012047 Cinnamyl alcohol dehydrogenases (CAD); Region: CAD1; cd05283 481805012048 putative NAD(P) binding site [chemical binding]; other site 481805012049 putative substrate binding site [chemical binding]; other site 481805012050 catalytic Zn binding site [ion binding]; other site 481805012051 structural Zn binding site [ion binding]; other site 481805012052 dimer interface [polypeptide binding]; other site 481805012053 Bacterial protein of unknown function (DUF853); Region: DUF853; pfam05872 481805012054 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cl17189 481805012055 Walker A motif; other site 481805012056 ATP binding site [chemical binding]; other site 481805012057 lipopolysaccharide ABC transporter permease; Provisional; Region: PRK15071 481805012058 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 481805012059 lipopolysaccharide ABC transporter permease LptF; Provisional; Region: PRK15120 481805012060 Predicted permease YjgP/YjgQ family; Region: YjgP_YjgQ; pfam03739 481805012061 multifunctional aminopeptidase A; Provisional; Region: PRK00913 481805012062 Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and...; Region: Peptidase_M17; cd00433 481805012063 interface (dimer of trimers) [polypeptide binding]; other site 481805012064 Substrate-binding/catalytic site; other site 481805012065 Zn-binding sites [ion binding]; other site 481805012066 DNA polymerase III subunit chi; Validated; Region: PRK05728 481805012067 valyl-tRNA synthetase; Reviewed; Region: valS; PRK05729 481805012068 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 481805012069 HIGH motif; other site 481805012070 Leucyl-tRNA synthetase, Domain 2; Region: tRNA-synt_1_2; pfam13603 481805012071 catalytic core domain of valyl-tRNA synthetases; Region: ValRS_core; cd00817 481805012072 active site 481805012073 KMSKS motif; other site 481805012074 Anticodon-binding domain of valyl tRNA synthetases; Region: Anticodon_Ia_Val; cd07962 481805012075 tRNA binding surface [nucleotide binding]; other site 481805012076 anticodon binding site; other site 481805012077 Valyl tRNA synthetase tRNA binding arm; Region: Val_tRNA-synt_C; pfam10458 481805012078 Predicted membrane protein [Function unknown]; Region: COG4269 481805012079 Acetyltransferases [General function prediction only]; Region: RimI; COG0456 481805012080 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481805012081 Coenzyme A binding pocket [chemical binding]; other site 481805012082 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3076 481805012083 RNase E inhibitor protein; Provisional; Region: PRK11191 481805012084 ornithine carbamoyltransferase subunit I; Provisional; Region: PRK03515 481805012085 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 481805012086 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 481805012087 Beta-galactosidase, beta subunit [Carbohydrate transport and metabolism]; Region: EbgC; COG2731 481805012088 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481805012089 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481805012090 oxidoreductase; Provisional; Region: PRK12742 481805012091 classical (c) SDRs; Region: SDR_c; cd05233 481805012092 NAD(P) binding site [chemical binding]; other site 481805012093 active site 481805012094 YjgH belongs to a large family of YjgF/YER057c/UK114-like proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgH_like; cd02198 481805012095 homotrimer interaction site [polypeptide binding]; other site 481805012096 putative active site [active] 481805012097 PyrBI operon leader peptide; Region: PyrBI_leader; pfam08052 481805012098 aspartate carbamoyltransferase; Region: asp_carb_tr; TIGR00670 481805012099 Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Region: OTCace_N; pfam02729 481805012100 Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; Region: OTCace; pfam00185 481805012101 aspartate carbamoyltransferase regulatory subunit; Reviewed; Region: PRK00893 481805012102 Aspartate carbamoyltransferase regulatory chain, allosteric domain; Region: PyrI; pfam01948 481805012103 Aspartate carbamoyltransferase regulatory chain, metal binding domain; Region: PyrI_C; pfam02748 481805012104 YjgF, YER057c, and UK114 belong to a large family of proteins present in bacteria, archaea, and eukaryotes with no definitive function. The conserved domain is similar in structure to chorismate mutase but there is no sequence similarity and no...; Region: YjgF_YER057c_UK114_family; cd00448 481805012105 homotrimer interaction site [polypeptide binding]; other site 481805012106 putative active site [active] 481805012107 magnesium-transporting ATPase MgtA; Provisional; Region: PRK10517 481805012108 Cation transporter/ATPase, N-terminus; Region: Cation_ATPase_N; pfam00690 481805012109 E1-E2 ATPase; Region: E1-E2_ATPase; pfam00122 481805012110 Putative hydrolase of sodium-potassium ATPase alpha subunit; Region: Hydrolase_like2; pfam13246 481805012111 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805012112 motif II; other site 481805012113 Cation transporting ATPase, C-terminus; Region: Cation_ATPase_C; pfam00689 481805012114 trehalose repressor; Provisional; Region: treR; PRK09492 481805012115 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481805012116 DNA binding site [nucleotide binding] 481805012117 domain linker motif; other site 481805012118 Ligand-binding domain of DNA transcription repressor specific for trehalose (TreR) which is a member of the LacI-GalR family of bacterial transcription regulators; Region: PBP1_TreR_like; cd01542 481805012119 dimerization interface [polypeptide binding]; other site 481805012120 ligand binding site [chemical binding]; other site 481805012121 PTS system trehalose(maltose)-specific transporter subunits IIBC; Provisional; Region: PRK11007 481805012122 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 481805012123 active site turn [active] 481805012124 phosphorylation site [posttranslational modification] 481805012125 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 481805012126 trehalose-6-phosphate hydrolase; Provisional; Region: PRK10933 481805012127 Alpha amylase catalytic domain found in Sucrose isomerases, oligo-1,6-glucosidase (also called isomaltase; sucrase-isomaltase; alpha-limit dextrinase), dextran glucosidase (also called glucan 1,6-alpha-glucosidase), and related proteins; Region: AmyAc_SI_OligoGlu_DGase; cd11333 481805012128 Ca binding site [ion binding]; other site 481805012129 active site 481805012130 catalytic site [active] 481805012131 anaerobic ribonucleoside triphosphate reductase; Provisional; Region: PRK09263 481805012132 ATP cone domain; Region: ATP-cone; pfam03477 481805012133 Class III ribonucleotide reductase; Region: RNR_III; cd01675 481805012134 effector binding site; other site 481805012135 active site 481805012136 Zn binding site [ion binding]; other site 481805012137 glycine loop; other site 481805012138 anaerobic ribonucleoside-triphosphate reductase activating protein; Region: NrdG; TIGR02491 481805012139 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805012140 FeS/SAM binding site; other site 481805012141 cytochrome b562; Provisional; Region: PRK15058 481805012142 peptidase PmbA; Provisional; Region: PRK11040 481805012143 hypothetical protein; Provisional; Region: PRK05255 481805012144 UDP-N-acetylmuramate:L-alanyl-gamma-D-glutamyl- meso-diaminopimelate ligase; Region: mpl; TIGR01081 481805012145 Mur ligase family, catalytic domain; Region: Mur_ligase; pfam01225 481805012146 Mur ligase middle domain; Region: Mur_ligase_M; pfam08245 481805012147 Mur ligase family, glutamate ligase domain; Region: Mur_ligase_C; pfam02875 481805012148 Fructose-1,6-bisphosphatase, an enzyme that catalyzes the hydrolysis of fructose-1,6-biphosphate into fructose-6-phosphate and is critical in gluconeogenesis pathway. The alignment model also includes chloroplastic FBPases and sedoheptulose-1; Region: FBPase; cd00354 481805012149 AMP binding site [chemical binding]; other site 481805012150 metal binding site [ion binding]; metal-binding site 481805012151 active site 481805012152 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481805012153 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481805012154 TM-ABC transporter signature motif; other site 481805012155 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481805012156 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481805012157 TM-ABC transporter signature motif; other site 481805012158 ABC-type sugar transport system, ATPase component [Carbohydrate transport and metabolism]; Region: MglA; COG1129 481805012159 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 481805012160 Walker A/P-loop; other site 481805012161 ATP binding site [chemical binding]; other site 481805012162 Q-loop/lid; other site 481805012163 ABC transporter signature motif; other site 481805012164 Walker B; other site 481805012165 D-loop; other site 481805012166 H-loop/switch region; other site 481805012167 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481805012168 Periplasmic binding domain of ABC-type YtfQ-like transport systems; Region: PBP1_YtfQ_like; cd06309 481805012169 Periplasmic binding protein domain; Region: Peripla_BP_4; pfam13407 481805012170 putative ligand binding site [chemical binding]; other site 481805012171 Inorganic pyrophosphatase. These enzymes hydrolyze inorganic pyrophosphate (PPi) to two molecules of orthophosphates (Pi). The reaction requires bivalent cations. The enzymes in general exist as homooligomers; Region: pyrophosphatase; cd00412 481805012172 dimer interface [polypeptide binding]; other site 481805012173 substrate binding site [chemical binding]; other site 481805012174 metal binding sites [ion binding]; metal-binding site 481805012175 GGCT-like domains, also called AIG2-like family. Gamma-glutamyl cyclotransferase (GGCT) catalyzes the formation of pyroglutamic acid (5-oxoproline) from dipeptides containing gamma-glutamyl, and is a dimeric protein. In Homo sapiens, the protein is...; Region: GGCT_like; cd06661 481805012176 putative active site pocket [active] 481805012177 dimerization interface [polypeptide binding]; other site 481805012178 putative catalytic residue [active] 481805012179 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG2911 481805012180 Family of unknown function (DUF490); Region: DUF490; pfam04357 481805012181 Outer membrane protein [Cell envelope biogenesis, outer membrane]; Region: COG0729 481805012182 Surface antigen variable number repeat; Region: Surf_Ag_VNR; pfam07244 481805012183 Surface antigen; Region: Bac_surface_Ag; pfam01103 481805012184 methionine sulfoxide reductase A; Provisional; Region: PRK00058 481805012185 Hemolysins and related proteins containing CBS domains [General function prediction only]; Region: TlyC; COG1253 481805012186 Domain of unknown function DUF21; Region: DUF21; pfam01595 481805012187 This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains associated with the CorC_HlyC domain. CorC_HlyC is a transporter associated domain. This small domain is found in Na+/H+ antiporters, in proteins involved in...; Region: CBS_pair_CorC_HlyC_assoc; cd04590 481805012188 Transporter associated domain; Region: CorC_HlyC; smart01091 481805012189 Protein of unknown function (DUF1107); Region: DUF1107; pfam06526 481805012190 Predicted transcriptional regulator [General function prediction only]; Region: COG3054 481805012191 CysQ, a 3'-Phosphoadenosine-5'-phosphosulfate (PAPS) 3'-phosphatase, is a bacterial member of the inositol monophosphatase family. It has been proposed that CysQ helps control intracellular levels of PAPS, which is an intermediate in...; Region: CysQ; cd01638 481805012192 Archaeal fructose-1,6-bisphosphatase and related enzymes of inositol monophosphatase family [Carbohydrate transport and metabolism]; Region: SuhB; COG0483 481805012193 active site 481805012194 bifunctional 2',3'-cyclic nucleotide 2'-phosphodiesterase/3'-nucleotidase periplasmic precursor protein; Reviewed; Region: cpdB; PRK09420 481805012195 Escherichia coli CpdB and related proteins, N-terminal metallophosphatase domain; Region: MPP_CpdB_N; cd07410 481805012196 active site 481805012197 metal binding site [ion binding]; metal-binding site 481805012198 5'-nucleotidase, C-terminal domain; Region: 5_nucleotid_C; pfam02872 481805012199 Predicted transcriptional regulators [Transcription]; Region: COG1733 481805012200 HxlR-like helix-turn-helix; Region: HxlR; pfam01638 481805012201 Predicted nucleoside-diphosphate-sugar epimerases [Cell envelope biogenesis, outer membrane / Carbohydrate transport and metabolism]; Region: COG0702 481805012202 triphenylmethane reductase (TMR)-like proteins, NMRa-like, atypical (a) SDRs; Region: TMR_SDR_a; cd05269 481805012203 NADP binding site [chemical binding]; other site 481805012204 Permeases of the drug/metabolite transporter (DMT) superfamily [Carbohydrate transport and metabolism / Amino acid transport and metabolism / General function prediction only]; Region: RhaT; COG0697 481805012205 EamA-like transporter family; Region: EamA; pfam00892 481805012206 iron-sulfur cluster repair di-iron protein; Provisional; Region: PRK10992 481805012207 Domain of Unknown function (DUF542); Region: ScdA_N; pfam04405 481805012208 Hemerythrin-like domain; Region: Hr-like; cd12108 481805012209 Fe binding site [ion binding]; other site 481805012210 D-alanine/D-serine/glycine permease; Provisional; Region: PRK11049 481805012211 peptidyl-prolyl cis-trans isomerase; Provisional; Region: PRK11570 481805012212 Domain amino terminal to FKBP-type peptidyl-prolyl isomerase; Region: FKBP_N; pfam01346 481805012213 FKBP-type peptidyl-prolyl cis-trans isomerase; Region: FKBP_C; pfam00254 481805012214 Cell envelope opacity-associated protein A [Cell envelope biogenesis, outer membrane]; Region: OapA; COG3061 481805012215 Opacity-associated protein A N-terminal motif; Region: OapA_N; pfam08525 481805012216 Opacity-associated protein A LysM-like domain; Region: OapA; pfam04225 481805012217 Transcriptional regulator [Transcription]; Region: AcrR; COG1309 481805012218 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481805012219 3-ketoacyl-(acyl-carrier-protein) reductase; Provisional; Region: PRK12745 481805012220 putative beta-ketoacyl acyl carrier protein [ACP] reductase (BKR), subgroup 1, classical (c) SDR; Region: BKR_1_SDR_c; cd05337 481805012221 putative NAD(P) binding site [chemical binding]; other site 481805012222 active site 481805012223 Sugar phosphate isomerases/epimerases [Carbohydrate transport and metabolism]; Region: IolE; COG1082 481805012224 Enoyl-CoA hydratase/carnithine racemase [Lipid metabolism]; Region: CaiD; COG1024 481805012225 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 481805012226 substrate binding site [chemical binding]; other site 481805012227 oxyanion hole (OAH) forming residues; other site 481805012228 trimer interface [polypeptide binding]; other site 481805012229 Succinate dehydrogenase/fumarate reductase, flavoprotein subunit [Energy production and conversion]; Region: SdhA; COG1053 481805012230 L-aspartate oxidase; Provisional; Region: PRK06175 481805012231 L-aspartate oxidase; Provisional; Region: PRK06175 481805012232 TRAP-type C4-dicarboxylate transport system, small permease component [Carbohydrate transport and metabolism]; Region: DctM; COG3090 481805012233 DctM-like transporters; Region: DctM; pfam06808 481805012234 TRAP-type C4-dicarboxylate transport system, large permease component [Carbohydrate transport and metabolism]; Region: DctQ; COG1593 481805012235 TRAP-type C4-dicarboxylate transport system, periplasmic component [Carbohydrate transport and metabolism]; Region: DctP; COG1638 481805012236 Bacterial extracellular solute-binding protein, family 7; Region: SBP_bac_7; pfam03480 481805012237 50S ribosomal protein L9; Reviewed; Region: rplI; PRK00137 481805012238 Ribosomal protein L9, N-terminal domain; Region: Ribosomal_L9_N; pfam01281 481805012239 Ribosomal protein L9, C-terminal domain; Region: Ribosomal_L9_C; pfam03948 481805012240 30S ribosomal protein S18; Reviewed; Region: rpsR; PRK00391 481805012241 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 481805012242 dimer interface [polypeptide binding]; other site 481805012243 ssDNA binding site [nucleotide binding]; other site 481805012244 tetramer (dimer of dimers) interface [polypeptide binding]; other site 481805012245 30S ribosomal protein S6; Reviewed; Region: rpsF; PRK00453 481805012246 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 481805012247 L-ribulose-5-phosphate 4-epimerase; Reviewed; Region: araD; PRK08193 481805012248 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 481805012249 intersubunit interface [polypeptide binding]; other site 481805012250 active site 481805012251 Zn2+ binding site [ion binding]; other site 481805012252 L-xylulose 5-phosphate 3-epimerase; Reviewed; Region: PRK13209 481805012253 AP endonuclease family 2; These endonucleases play a role in DNA repair. Cleave phosphodiester bonds at apurinic or apyrimidinic sites; the alignment also contains hexulose-6-phosphate isomerases, enzymes that catalyze the epimerization of...; Region: AP2Ec; cd00019 481805012254 AP (apurinic/apyrimidinic) site pocket; other site 481805012255 DNA interaction; other site 481805012256 Metal-binding active site; metal-binding site 481805012257 3-Keto-L-gulonate 6-phosphate decarboxylase (KGPDC) and D-arabino-3-hexulose-6-phosphate synthase (HPS). KGPDC catalyzes the formation of L-xylulose 5-phosphate and carbon dioxide from 3-keto-L-gulonate 6-phosphate as part of the anaerobic pathway for...; Region: KGPDC_HPS; cd04726 481805012258 active site 481805012259 dimer interface [polypeptide binding]; other site 481805012260 magnesium binding site [ion binding]; other site 481805012261 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481805012262 active site 481805012263 phosphorylation site [posttranslational modification] 481805012264 PTS_IIB_ascorbate: subunit IIB of enzyme II (EII) of the L-ascorbate-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII is an L-ascorbate-specific permease with two cytoplasmic subunits (IIA and IIB) and a...; Region: PTS_IIB_ascorbate; cd05563 481805012265 active site 481805012266 P-loop; other site 481805012267 phosphorylation site [posttranslational modification] 481805012268 Uncharacterized protein conserved in bacteria [Function unknown]; Region: SgaT; COG3037 481805012269 PTS system ascorbate-specific transporter subunits IICB; Provisional; Region: PRK09548 481805012270 putative L-ascorbate 6-phosphate lactonase; Provisional; Region: PRK11709 481805012271 Predicted Zn-dependent hydrolases of the beta-lactamase fold [General function prediction only]; Region: COG2220 481805012272 transcriptional repressor UlaR; Provisional; Region: PRK13509 481805012273 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 481805012274 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481805012275 esterase; Provisional; Region: PRK10566 481805012276 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 481805012277 Prolyl oligopeptidase family; Region: Peptidase_S9; pfam00326 481805012278 putative biofilm stress and motility protein A; Provisional; Region: PRK14864 481805012279 Protein of unknown function (DUF1471); Region: DUF1471; pfam07338 481805012280 isovaleryl CoA dehydrogenase; Provisional; Region: PRK11561 481805012281 Proteins involved in DNA damage response, similar to the AidB gene product; Region: AidB; cd01154 481805012282 FAD binding site [chemical binding]; other site 481805012283 substrate binding site [chemical binding]; other site 481805012284 catalytic residues [active] 481805012285 Glutathionylspermidine synthase [Amino acid transport and metabolism]; Region: Gsp; COG0754 481805012286 Protein of unknown function (DUF1190); Region: DUF1190; cl10031 481805012287 Predicted membrane protein [Function unknown]; Region: COG3766 481805012288 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 481805012289 Domain of Unknown Function (DUF350); Region: DUF350; pfam03994 481805012290 Protein of unknown function (DUF2491); Region: DUF2491; pfam10679 481805012291 PspA/IM30 family; Region: PspA_IM30; pfam04012 481805012292 Uncharacterized protein conserved in bacteria (DUF2170); Region: DUF2170; cl01551 481805012293 23S rRNA (guanosine-2'-O-)-methyltransferase; Provisional; Region: PRK11181 481805012294 RNA 2'-O ribose methyltransferase substrate binding; Region: SpoU_sub_bind; smart00967 481805012295 SpoU rRNA Methylase family; Region: SpoU_methylase; pfam00588 481805012296 exoribonuclease R; Provisional; Region: PRK11642 481805012297 Ribonuclease R winged-helix domain; Region: HTH_12; pfam08461 481805012298 Ribonuclease B OB domain; Region: OB_RNB; pfam08206 481805012299 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 481805012300 RNB domain; Region: RNB; pfam00773 481805012301 S1_RNase_R: RNase R C-terminal S1 domain. RNase R is a processive 3' to 5' exoribonuclease, which is a homolog of RNase II. RNase R degrades RNA with secondary structure having a 3' overhang of at least 7 nucleotides. RNase R and PNPase...; Region: S1_RNase_R; cd04471 481805012302 RNA binding site [nucleotide binding]; other site 481805012303 Predicted transcriptional regulator [Transcription]; Region: COG1959 481805012304 transcriptional repressor NsrR; Provisional; Region: PRK11014 481805012305 Adenylosuccinate synthetase; Region: Adenylsucc_synt; smart00788 481805012306 Adenylosuccinate synthetase (AdSS) catalyzes the first step in the de novo biosynthesis of AMP. IMP and L-aspartate are conjugated in a two-step reaction accompanied by the hydrolysis of GTP to GDP in the presence of Mg2+. In the first step, the...; Region: AdSS; cd03108 481805012307 GDP-binding site [chemical binding]; other site 481805012308 ACT binding site; other site 481805012309 IMP binding site; other site 481805012310 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3242 481805012311 FtsH protease regulator HflC; Provisional; Region: PRK11029 481805012312 Band_7_HflC: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfC (High frequency of lysogenization C). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflC; cd03405 481805012313 FtsH protease regulator HflK; Provisional; Region: PRK10930 481805012314 Bacterial membrane protein N terminal; Region: HflK_N; pfam12221 481805012315 Band_7_HflK: The band 7 domain of flotillin (reggie) like proteins. This group includes proteins similar to prokaryotic HlfK (High frequency of lysogenization K). Although many members of the band 7 family are lipid raft associated, prokaryote plasma...; Region: Band_7_HflK; cd03404 481805012316 GTPase HflX; Provisional; Region: PRK11058 481805012317 GTP-binding GTPase N-terminal; Region: GTP-bdg_N; pfam13167 481805012318 HflX GTPase family; Region: HflX; cd01878 481805012319 G1 box; other site 481805012320 GTP/Mg2+ binding site [chemical binding]; other site 481805012321 Switch I region; other site 481805012322 G2 box; other site 481805012323 G3 box; other site 481805012324 Switch II region; other site 481805012325 G4 box; other site 481805012326 G5 box; other site 481805012327 bacterial Hfq-like; Region: Hfq; cd01716 481805012328 hexamer interface [polypeptide binding]; other site 481805012329 Sm1 motif; other site 481805012330 RNA binding site [nucleotide binding]; other site 481805012331 Sm2 motif; other site 481805012332 tRNA delta(2)-isopentenylpyrophosphate transferase; Reviewed; Region: miaA; PRK00091 481805012333 tRNA delta(2)-isopentenylpyrophosphate transferase [Translation, ribosomal structure and biogenesis]; Region: MiaA; COG0324 481805012334 DNA mismatch repair protein; Reviewed; Region: mutL; PRK00095 481805012335 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805012336 ATP binding site [chemical binding]; other site 481805012337 Mg2+ binding site [ion binding]; other site 481805012338 G-X-G motif; other site 481805012339 MutL_Trans_MutL: transducer domain, having a ribosomal S5 domain 2-like fold, found in proteins similar to Escherichia coli MutL. EcMutL belongs to the DNA mismatch repair (MutL/MLH1/PMS2) family. This transducer domain is homologous to the second...; Region: MutL_Trans_MutL; cd03482 481805012340 ATP binding site [chemical binding]; other site 481805012341 MutL C terminal dimerisation domain; Region: MutL_C; pfam08676 481805012342 N-acetylmuramoyl-l-alanine amidase II; Provisional; Region: PRK10431 481805012343 AMIN domain; Region: AMIN; pfam11741 481805012344 N-acetylmuramoyl-L-alanine amidase or MurNAc-LAA (also known as peptidoglycan aminohydrolase, NAMLA amidase, NAMLAA, Amidase 3, and peptidoglycan amidase; EC 3.5.1.28) is an autolysin that hydrolyzes the amide bond between N-acetylmuramoyl and L-amino...; Region: MurNAc-LAA; cd02696 481805012345 active site 481805012346 metal binding site [ion binding]; metal-binding site 481805012347 ADP-binding protein; Provisional; Region: PRK10646 481805012348 putative carbohydrate kinase; Provisional; Region: PRK10565 481805012349 yjeF N-terminal region; Region: yjeF_nterm; TIGR00197 481805012350 B.subtilis YXKO protein of unknown function and related proteins. Based on the conservation of the ATP binding site, the substrate binding site and the Mg2+binding site and structural homology this group is a member of the ribokinase-like superfamily; Region: YXKO-related; cd01171 481805012351 putative substrate binding site [chemical binding]; other site 481805012352 putative ATP binding site [chemical binding]; other site 481805012353 epoxyqueuosine reductase; Region: TIGR00276 481805012354 Domain of unknown function (DUF1730); Region: DUF1730; pfam08331 481805012355 DEDDh 3'-5' exonuclease domain of oligoribonuclease and similar proteins; Region: Orn; cd06135 481805012356 catalytic site [active] 481805012357 putative active site [active] 481805012358 putative substrate binding site [chemical binding]; other site 481805012359 dimer interface [polypeptide binding]; other site 481805012360 GTPase RsgA; Reviewed; Region: PRK12288 481805012361 S1_like: Ribosomal protein S1-like RNA-binding domain. Found in a wide variety of RNA-associated proteins. Originally identified in S1 ribosomal protein. This superfamily also contains the Cold Shock Domain (CSD), which is a homolog of the S1 domain; Region: S1_like; cl09927 481805012362 RNA binding site [nucleotide binding]; other site 481805012363 Ribosomal interacting GTPase YjeQ/EngC, a circularly permuted subfamily of the Ras GTPases; Region: YjeQ_EngC; cd01854 481805012364 GTPase/Zn-binding domain interface [polypeptide binding]; other site 481805012365 GTP/Mg2+ binding site [chemical binding]; other site 481805012366 G4 box; other site 481805012367 G5 box; other site 481805012368 G1 box; other site 481805012369 Switch I region; other site 481805012370 G2 box; other site 481805012371 G3 box; other site 481805012372 Switch II region; other site 481805012373 phosphatidylserine decarboxylase; Reviewed; Region: psd; PRK00044 481805012374 putative mechanosensitive channel protein; Provisional; Region: PRK10929 481805012375 linker histone 1 and histone 5 domains; the basic subunit of chromatin is the nucleosome, consisting of an octamer of core histones, two full turns of DNA, a linker histone (H1 or H5) and a variable length of linker DNA; H1/H5 are chromatin-associated...; Region: H15; cl00073 481805012376 DNA-binding site [nucleotide binding]; DNA binding site 481805012377 Mechanosensitive ion channel inner membrane domain 1; Region: MscS_TM; pfam12794 481805012378 Mechanosensitive ion channel; Region: MS_channel; pfam00924 481805012379 Protein of unknown function (DUF2645); Region: DUF2645; pfam10840 481805012380 inner membrane transporter YjeM; Provisional; Region: PRK15238 481805012381 poxB regulator PoxA; Provisional; Region: PRK09350 481805012382 Class II tRNA amino-acyl synthetase-like catalytic core domain. Class II amino acyl-tRNA synthetases (aaRS) share a common fold and generally attach an amino acid to the 3' OH of ribose of the appropriate tRNA. PheRS is an exception in that it...; Region: class_II_aaRS-like_core; cl00268 481805012383 motif 1; other site 481805012384 dimer interface [polypeptide binding]; other site 481805012385 active site 481805012386 motif 2; other site 481805012387 motif 3; other site 481805012388 fumarate reductase flavoprotein subunit; Validated; Region: PRK09231 481805012389 L-aspartate oxidase; Provisional; Region: PRK06175 481805012390 Fumarate reductase flavoprotein C-term; Region: Succ_DH_flav_C; pfam02910 481805012391 fumarate reductase iron-sulfur subunit; Provisional; Region: PRK12385 481805012392 2Fe-2S iron-sulfur cluster binding domain; Region: Fer2_3; pfam13085 481805012393 Quinol:fumarate reductase (QFR) Type D subfamily, 15kD hydrophobic subunit C; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitC; cd00546 481805012394 D-subunit interface [polypeptide binding]; other site 481805012395 Iron-sulfur protein interface; other site 481805012396 proximal quinone binding site [chemical binding]; other site 481805012397 distal quinone binding site [chemical binding]; other site 481805012398 Quinol:fumarate reductase (QFR) Type D subfamily, 13kD hydrophobic subunit D; QFR couples the reduction of fumarate to succinate to the oxidation of quinol to quinone, the opposite reaction to that catalyzed by the related protein, succinate:quinine...; Region: QFR_TypeD_subunitD; cd00547 481805012399 Iron-sulfur protein interface; other site 481805012400 proximal quinone binding site [chemical binding]; other site 481805012401 C-subunit interface; other site 481805012402 distal quinone binding site; other site 481805012403 beta-lactamase/D-alanine carboxypeptidase; Provisional; Region: ampC; PRK11289 481805012404 Beta-lactamase class C and other penicillin binding proteins [Defense mechanisms]; Region: AmpC; COG1680 481805012405 Bacterial lipocalin [Cell envelope biogenesis, outer membrane]; Region: Blc; COG3040 481805012406 Lipocalin-like domain; Region: Lipocalin_2; pfam08212 481805012407 multidrug efflux system protein; Provisional; Region: PRK11431 481805012408 entericidin B membrane lipoprotein; Provisional; Region: PRK10081 481805012409 entericidin A; Provisional; Region: PRK09810 481805012410 elongation factor P; Validated; Region: PRK00529 481805012411 Elongation factor P (EF-P) KOW-like domain; Region: EFP_N; pfam08207 481805012412 S1_EF-P_repeat_1: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_1; cd04470 481805012413 RNA binding site [nucleotide binding]; other site 481805012414 S1_EF-P_repeat_2: Translation elongation factor P (EF-P), S1-like RNA-binding domain, repeat 1. EF-P stimulates the peptidyltransferase activity in the prokaryotic 70S ribosome. EF-P enhances the synthesis of certain dipeptides with...; Region: S1_EF-P_repeat_2; cd05794 481805012415 RNA binding site [nucleotide binding]; other site 481805012416 Lysine 2,3-aminomutase [Amino acid transport and metabolism]; Region: KamA; COG1509 481805012417 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805012418 FeS/SAM binding site; other site 481805012419 Domain of unknown function (DUF4156); Region: DUF4156; pfam13698 481805012420 chaperonin GroEL; Reviewed; Region: groEL; PRK12849 481805012421 GroEL_like type I chaperonin. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings, each composed of 7-9 subunits. The symmetry of type I is seven-fold and they are found...; Region: GroEL; cd03344 481805012422 ring oligomerisation interface [polypeptide binding]; other site 481805012423 ATP/Mg binding site [chemical binding]; other site 481805012424 stacking interactions; other site 481805012425 hinge regions; other site 481805012426 Chaperonin 10 Kd subunit (cpn10 or GroES); Cpn10 cooperates with chaperonin 60 (cpn60 or GroEL), an ATPase, to assist the folding and assembly of proteins and is found in eubacterial cytosol, as well as in the matrix of mitochondria and chloroplasts. It...; Region: cpn10; cd00320 481805012427 oligomerisation interface [polypeptide binding]; other site 481805012428 mobile loop; other site 481805012429 roof hairpin; other site 481805012430 putative transporter; Provisional; Region: PRK11021 481805012431 Protein affecting phage T7 exclusion by the F plasmid [General function prediction only]; Region: FxsA; COG3030 481805012432 aspartate ammonia-lyase; Provisional; Region: aspA; PRK12273 481805012433 Aspartase; Region: Aspartase; cd01357 481805012434 active sites [active] 481805012435 tetramer interface [polypeptide binding]; other site 481805012436 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 481805012437 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK09412 481805012438 divalent-cation tolerance protein CutA; Provisional; Region: PRK10645 481805012439 thiol:disulfide interchange protein precursor; Provisional; Region: dipZ; PRK00293 481805012440 Disulphide bond corrector protein DsbC; Region: DsbC; pfam11412 481805012441 Cytochrome C biogenesis protein transmembrane region; Region: DsbD; cl15788 481805012442 DsbD gamma family; DsbD gamma is the C-terminal periplasmic domain of the bacterial protein DsbD. It contains a CXXC motif in a TRX fold and shuttles the reducing potential from the membrane domain (DsbD beta) to the N-terminal periplasmic domain (DsbD...; Region: DsbDgamma; cd02953 481805012443 DsbD alpha interface [polypeptide binding]; other site 481805012444 catalytic residues [active] 481805012445 putative transcriptional regulator; Provisional; Region: PRK11640 481805012446 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481805012447 integrase; Provisional; Region: PRK09692 481805012448 Bacteriophage P4 integrase. P4-like integrases are found in temperate bacteriophages, integrative plasmids, pathogenicity and symbiosis islands, and other mobile genetic elements. They share the same fold in their catalytic domain and the overall...; Region: INT_P4; cd00801 481805012449 active site 481805012450 Int/Topo IB signature motif; other site 481805012451 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805012452 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805012453 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805012454 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805012455 Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]; Region: UvrD; COG0210 481805012456 Part of AAA domain; Region: AAA_19; pfam13245 481805012457 Family description; Region: UvrD_C_2; pfam13538 481805012458 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 481805012459 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481805012460 ATP binding site [chemical binding]; other site 481805012461 putative Mg++ binding site [ion binding]; other site 481805012462 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805012463 ATP-binding site [chemical binding]; other site 481805012464 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 481805012465 Type II restriction enzyme, methylase subunits [Defense mechanisms]; Region: COG1002 481805012466 Superfamily II DNA/RNA helicases, SNF2 family [Transcription / DNA replication, recombination, and repair]; Region: HepA; COG0553 481805012467 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481805012468 ATP binding site [chemical binding]; other site 481805012469 putative Mg++ binding site [ion binding]; other site 481805012470 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805012471 nucleotide binding region [chemical binding]; other site 481805012472 ATP-binding site [chemical binding]; other site 481805012473 Distinct helicase family with a unique C-terminal domain including a metal-binding cysteine cluster [General function prediction only]; Region: COG1205 481805012474 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481805012475 ATP binding site [chemical binding]; other site 481805012476 putative Mg++ binding site [ion binding]; other site 481805012477 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805012478 nucleotide binding region [chemical binding]; other site 481805012479 ATP-binding site [chemical binding]; other site 481805012480 Domain of unknown function (DUF1998); Region: DUF1998; pfam09369 481805012481 Capsid triplex subunit 2; Provisional; Region: PHA03259 481805012482 Protein of unknown function (DUF3375); Region: DUF3375; pfam11855 481805012483 Outer membrane protein and related peptidoglycan-associated (lipo)proteins [Cell envelope biogenesis, outer membrane]; Region: OmpA; COG2885 481805012484 Peptidoglycan binding domains similar to the C-terminal domain of outer-membrane protein OmpA; Region: OmpA_C-like; cd07185 481805012485 ligand binding site [chemical binding]; other site 481805012486 Restriction endonuclease [Defense mechanisms]; Region: McrA; COG1403 481805012487 HNH nucleases; HNH endonuclease signature which is found in viral, prokaryotic, and eukaryotic proteins. The alignment includes members of the large group of homing endonucleases, yeast intron 1 protein, MutS, as well as bacterial colicins, pyocins, and...; Region: HNHc; cd00085 481805012488 active site 481805012489 N-acetylneuraminic acid mutarotase; Provisional; Region: PRK14131 481805012490 Transposase domain (DUF772); Region: DUF772; pfam05598 481805012491 Transposase and inactivated derivatives, IS5 family [DNA replication, recombination, and repair]; Region: COG3039 481805012492 Transposase DDE domain; Region: DDE_Tnp_1_6; pfam13751 481805012493 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805012494 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805012495 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805012496 IS1 transposase; Region: DDE_Tnp_IS1; cl00721 481805012497 DNA-binding transcriptional activator CadC; Provisional; Region: PRK10153 481805012498 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805012499 DNA binding site [nucleotide binding] 481805012500 lysine/cadaverine antiporter; Provisional; Region: cadB; PRK10435 481805012501 lysine decarboxylase CadA; Provisional; Region: PRK15400 481805012502 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 481805012503 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 481805012504 homodimer interface [polypeptide binding]; other site 481805012505 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805012506 catalytic residue [active] 481805012507 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 481805012508 Dipeptide/tripeptide permease [Amino acid transport and metabolism]; Region: PTR2; COG3104 481805012509 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805012510 putative substrate translocation pore; other site 481805012511 POT family; Region: PTR2; pfam00854 481805012512 lysyl-tRNA synthetase; Reviewed; Region: PRK12445 481805012513 LysRS_N: N-terminal, anticodon recognition domain of lysyl-tRNA synthetases (LysRS). These enzymes are homodimeric class 2b aminoacyl-tRNA synthetases (aaRSs). This domain is a beta-barrel domain (OB fold) involved in binding the tRNA anticodon stem-loop; Region: LysRS_N; cd04322 481805012514 dimer interface [polypeptide binding]; other site 481805012515 putative anticodon binding site; other site 481805012516 Lys_tRNA synthetase (LysRS) class II core domain. Class II LysRS is a dimer which attaches a lysine to the 3' OH group of ribose of the appropriate tRNA. Its assignment to class II aaRS is based upon its structure and the presence of three...; Region: LysRS_core; cd00775 481805012517 motif 1; other site 481805012518 active site 481805012519 motif 2; other site 481805012520 motif 3; other site 481805012521 Protein of unknown function (DUF2566); Region: DUF2566; pfam10753 481805012522 Predicted acetyltransferase [General function prediction only]; Region: COG2388 481805012523 Uncharacterized conserved protein [Function unknown]; Region: COG3592 481805012524 sensory histidine kinase DcuS; Provisional; Region: PRK11086 481805012525 PAS domain; Region: PAS; smart00091 481805012526 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805012527 ATP binding site [chemical binding]; other site 481805012528 Mg2+ binding site [ion binding]; other site 481805012529 G-X-G motif; other site 481805012530 DNA-binding transcriptional activator DcuR; Provisional; Region: PRK10430 481805012531 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805012532 active site 481805012533 phosphorylation site [posttranslational modification] 481805012534 intermolecular recognition site; other site 481805012535 dimerization interface [polypeptide binding]; other site 481805012536 Transcriptional regulator; Region: CitT; pfam12431 481805012537 Anaerobic C4-dicarboxylate transporter [General function prediction only]; Region: DcuB; COG2704 481805012538 anaerobic C4-dicarboxylate transporter; Reviewed; Region: PRK12489 481805012539 fumarate hydratase; Provisional; Region: PRK15389 481805012540 Tartrate dehydratase alpha subunit/Fumarate hydratase class I, N-terminal domain [Energy production and conversion]; Region: TtdA; COG1951 481805012541 Fumarase C-terminus; Region: Fumerase_C; pfam05683 481805012542 hypothetical protein; Provisional; Region: PRK09867 481805012543 melibiose:sodium symporter; Provisional; Region: PRK10429 481805012544 sugar (Glycoside-Pentoside-Hexuronide) transporter; Region: gph; TIGR00792 481805012545 alpha-galactosidase; Provisional; Region: PRK15076 481805012546 Glycoside Hydrolases Family 4; Alpha-glucosidases and alpha-galactosidases; Region: GH4_alpha_glucosidase_galactosidase; cd05297 481805012547 NAD binding site [chemical binding]; other site 481805012548 sugar binding site [chemical binding]; other site 481805012549 divalent metal binding site [ion binding]; other site 481805012550 putative tetramer (dimer of dimers) interface [polypeptide binding]; other site 481805012551 dimer interface [polypeptide binding]; other site 481805012552 DNA-binding transcriptional regulator MelR; Provisional; Region: PRK10371 481805012553 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805012554 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805012555 arginine decarboxylase; Provisional; Region: PRK15029 481805012556 Orn/Lys/Arg decarboxylase, N-terminal domain; Region: OKR_DC_1_N; pfam03709 481805012557 Ornithine decarboxylase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The major groups in this CD corresponds to ornithine decarboxylase (ODC), arginine decarboxylase (ADC) and lysine...; Region: Orn_deC_like; cd00615 481805012558 homodimer interface [polypeptide binding]; other site 481805012559 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805012560 catalytic residue [active] 481805012561 Orn/Lys/Arg decarboxylase, C-terminal domain; Region: OKR_DC_1_C; pfam03711 481805012562 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481805012563 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805012564 arginine:agmatin antiporter; Provisional; Region: PRK10644 481805012565 putative metal dependent hydrolase; Provisional; Region: PRK11598 481805012566 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 481805012567 Sulfatase; Region: Sulfatase; pfam00884 481805012568 DNA-binding transcriptional regulator BasR; Provisional; Region: PRK10643 481805012569 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805012570 active site 481805012571 phosphorylation site [posttranslational modification] 481805012572 intermolecular recognition site; other site 481805012573 dimerization interface [polypeptide binding]; other site 481805012574 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805012575 DNA binding site [nucleotide binding] 481805012576 sensor protein BasS/PmrB; Provisional; Region: PRK10755 481805012577 HAMP domain; Region: HAMP; pfam00672 481805012578 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805012579 dimer interface [polypeptide binding]; other site 481805012580 phosphorylation site [posttranslational modification] 481805012581 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805012582 ATP binding site [chemical binding]; other site 481805012583 Mg2+ binding site [ion binding]; other site 481805012584 G-X-G motif; other site 481805012585 proline/glycine betaine transporter; Provisional; Region: PRK10642 481805012586 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805012587 putative substrate translocation pore; other site 481805012588 Osmosensory transporter coiled coil; Region: Osmo_CC; pfam08946 481805012589 YjcZ-like protein; Region: YjcZ; pfam13990 481805012590 hypothetical protein; Provisional; Region: PRK10220 481805012591 PhnA Zinc-Ribbon; Region: PhnA_Zn_Ribbon; pfam08274 481805012592 PhnA protein; Region: PhnA; pfam03831 481805012593 Escherichia coli PhnB and similar proteins; the E. coli phnB gene is found next to an operon involved in the cleavage of carbon-phosphorus bonds in unactivated alkylphosphonates; Region: PhnB_like; cd06588 481805012594 dimer interface [polypeptide binding]; other site 481805012595 Glyoxalase/Bleomycin resistance protein/Dioxygenase superfamily; Region: Glyoxalase; pfam00903 481805012596 phosphonate/organophosphate ester transporter subunit; Provisional; Region: PRK09984 481805012597 ATP-binding cassette domain of the binding protein-dependent phosphonate transport system; Region: ABC_PhnC_transporter; cd03256 481805012598 Walker A/P-loop; other site 481805012599 ATP binding site [chemical binding]; other site 481805012600 Q-loop/lid; other site 481805012601 ABC transporter signature motif; other site 481805012602 Walker B; other site 481805012603 D-loop; other site 481805012604 H-loop/switch region; other site 481805012605 phosphonate ABC transporter, periplasmic phosphonate binding protein; Region: PhnD; TIGR03431 481805012606 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805012607 substrate binding pocket [chemical binding]; other site 481805012608 membrane-bound complex binding site; other site 481805012609 hinge residues; other site 481805012610 ABC-type phosphate/phosphonate transport system, permease component [Inorganic ion transport and metabolism]; Region: COG3639 481805012611 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805012612 dimer interface [polypeptide binding]; other site 481805012613 conserved gate region; other site 481805012614 putative PBP binding loops; other site 481805012615 ABC-ATPase subunit interface; other site 481805012616 phosphonate metabolism transcriptional regulator PhnF; Provisional; Region: PRK10079 481805012617 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805012618 DNA-binding site [nucleotide binding]; DNA binding site 481805012619 UTRA domain; Region: UTRA; pfam07702 481805012620 Phosphonate metabolism protein PhnG; Region: PhnG; pfam06754 481805012621 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnH; COG3625 481805012622 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnI; COG3626 481805012623 Uncharacterized enzyme of phosphonate metabolism [Inorganic ion transport and metabolism]; Region: PhnJ; COG3627 481805012624 phosphonate C-P lyase system protein PhnK; Provisional; Region: phnK; PRK11701 481805012625 ATP-binding cassette domain of nickel/oligopeptides specific transporters; Region: ABC_NikE_OppD_transporters; cd03257 481805012626 Walker A/P-loop; other site 481805012627 ATP binding site [chemical binding]; other site 481805012628 Q-loop/lid; other site 481805012629 ABC transporter signature motif; other site 481805012630 Walker B; other site 481805012631 D-loop; other site 481805012632 H-loop/switch region; other site 481805012633 Oligopeptide/dipeptide transporter, C-terminal region; Region: oligo_HPY; cl07097 481805012634 ABC-type phosphonate transport system, ATPase component [Inorganic ion transport and metabolism]; Region: PhnL; COG4778 481805012635 ATP-binding cassette domain of the transporters involved in export of lipoprotein and macrolide, and cell division protein; Region: ABC_MJ0796_LolCDE_FtsE; cd03255 481805012636 Walker A/P-loop; other site 481805012637 ATP binding site [chemical binding]; other site 481805012638 Q-loop/lid; other site 481805012639 ABC transporter signature motif; other site 481805012640 Walker B; other site 481805012641 D-loop; other site 481805012642 H-loop/switch region; other site 481805012643 phosphonate metabolism protein PhnM; Provisional; Region: PRK15446 481805012644 Superfamily of metallo-dependent hydrolases (also called amidohydrolase superfamily) is a large group of proteins that show conservation in their 3-dimensional fold (TIM barrel) and in details of their active site. The vast majority of the members have a...; Region: metallo-dependent_hydrolases; cl00281 481805012645 PhnM is believed to be a subunit of the membrane associated C-P lyase complex. C-P lyase is thought to catalyze the direct cleavage of inactivated C-P bonds to yield inorganic phosphate and the corresponding hydrocarbons. It is responsible for cleavage...; Region: PhnM; cd01306 481805012646 active site 481805012647 ribose 1,5-bisphosphokinase; Provisional; Region: PRK10078 481805012648 AAA domain; Region: AAA_18; pfam13238 481805012649 active site 481805012650 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481805012651 Coenzyme A binding pocket [chemical binding]; other site 481805012652 carbon-phosphorus lyase complex accessory protein; Provisional; Region: phnP; PRK11244 481805012653 putative hydrolase; Provisional; Region: PRK02113 481805012654 ribose 5-phosphate isomerase B; Region: rpiB; TIGR01120 481805012655 DNA-binding transcriptional repressor RpiR; Provisional; Region: PRK11337 481805012656 Helix-turn-helix domain, rpiR family; Region: HTH_6; pfam01418 481805012657 RpiR-like protein. RpiR contains a SIS (Sugar ISomerase) domain, which is found in many phosphosugar isomerases and phosphosugar binding proteins. In E. coli, rpiR negatively regulates the expression of rpiB gene. Both rpiB and rpiA are ribose phosphate...; Region: SIS_RpiR; cd05013 481805012658 putative active site [active] 481805012659 D-allose transporter subunit; Provisional; Region: PRK09701 481805012660 Periplasmic allose-binding domain of bacterial transport systems that function as a primary receptor of active transport and chemotaxis; Region: PBP1_allose_binding; cd06320 481805012661 ligand binding site [chemical binding]; other site 481805012662 dimerization interface [polypeptide binding]; other site 481805012663 zinc binding site [ion binding]; other site 481805012664 D-allose transporter ATP-binding protein; Provisional; Region: PRK09700 481805012665 ATP-binding cassette transporter nucleotide-binding domain; Region: ABC_ATPase; cl17201 481805012666 Walker A/P-loop; other site 481805012667 ATP binding site [chemical binding]; other site 481805012668 Q-loop/lid; other site 481805012669 ABC transporter signature motif; other site 481805012670 Walker B; other site 481805012671 D-loop; other site 481805012672 H-loop/switch region; other site 481805012673 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481805012674 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481805012675 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481805012676 TM-ABC transporter signature motif; other site 481805012677 Pentose-5-phosphate-3-epimerase [Carbohydrate transport and metabolism]; Region: Rpe; COG0036 481805012678 Ribulose-5-phosphate 3-epimerase (RPE). This enzyme catalyses the interconversion of D-ribulose 5-phosphate (Ru5P) into D-xylulose 5-phosphate, as part of the Calvin cycle (reductive pentose phosphate pathway) in chloroplasts and in the oxidative pentose...; Region: RPE; cd00429 481805012679 substrate binding site [chemical binding]; other site 481805012680 hexamer interface [polypeptide binding]; other site 481805012681 metal binding site [ion binding]; metal-binding site 481805012682 D-allose kinase; Provisional; Region: PRK09698 481805012683 Nucleotide-Binding Domain of the sugar kinase/HSP70/actin superfamily; Region: NBD_sugar-kinase_HSP70_actin; cd00012 481805012684 nucleotide binding site [chemical binding]; other site 481805012685 Alkyl sulfatase and related hydrolases [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG2015 481805012686 Metallo-beta-lactamase superfamily; Region: Lactamase_B; smart00849 481805012687 multidrug resistance protein MdtN; Provisional; Region: PRK10476 481805012688 Biotin-lipoyl like; Region: Biotin_lipoyl_2; pfam13533 481805012689 HlyD family secretion protein; Region: HlyD_3; pfam13437 481805012690 multidrug efflux system protein MdtO; Provisional; Region: PRK11427 481805012691 Fusaric acid resistance protein-like; Region: FUSC_2; pfam13515 481805012692 putative outer membrane efflux protein MdtP; Provisional; Region: PRK09915 481805012693 formate dehydrogenase, alpha subunit, archaeal-type; Region: Fdh-alpha; TIGR01591 481805012694 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_Formate-Dh-H; cd02753 481805012695 [4Fe-4S] binding site [ion binding]; other site 481805012696 molybdopterin cofactor binding site; other site 481805012697 Formate dehydrogenase H (Formate-Dh-H) catalyzes the reversible oxidation of formate to CO2 with the release of a proton and two electrons. It is a component of the anaerobic formate hydrogen lyase complex. The E. coli formate dehydrogenase H (Fdh-H) is...; Region: MopB_CT_Formate-Dh_H; cd02790 481805012698 molybdopterin cofactor binding site; other site 481805012699 FOG: TPR repeat, SEL1 subfamily [General function prediction only]; Region: COG0790 481805012700 Sel1-like repeats; Region: SEL1; smart00671 481805012701 glutamate/aspartate:proton symporter; Provisional; Region: gltP; PRK11283 481805012702 Na+/H+-dicarboxylate symporters [Energy production and conversion]; Region: GltP; COG1301 481805012703 formate-dependent nitrite reductase complex subunit NrfG; Provisional; Region: PRK10370 481805012704 Tetratricopeptide repeat domain; typically contains 34 amino acids [WLF]-X(2)-[LIM]-[GAS]-X(2)-[YLF]-X(8)-[ASE]-X(3)-[FYL]- X(2)-[ASL]-X(4)-[PKE] is the consensus sequence; found in a variety of organisms including bacteria, cyanobacteria, yeast, fungi; Region: TPR; cd00189 481805012705 binding surface 481805012706 TPR motif; other site 481805012707 formate-dependent nitrite reductase complex subunit NrfF; Provisional; Region: PRK10144 481805012708 heme lyase subunit NrfE; Provisional; Region: PRK10369 481805012709 Formate-dependent nitrite reductase, membrane component [Inorganic ion transport and metabolism]; Region: NrfD; COG3301 481805012710 cytochrome c nitrite reductase, NrfD subunit; Region: cyt_nit_nrfD; TIGR03148 481805012711 cytochrome c nitrite reductase, Fe-S protein; Region: cyt_nit_nrfC; TIGR03149 481805012712 cytochrome c nitrite reductase pentaheme subunit; Provisional; Region: PRK11659 481805012713 cytochrome c nitrite reductase subunit c552; Provisional; Region: nrfA; PRK11125 481805012714 acetyl-CoA synthetase; Provisional; Region: PRK00174 481805012715 Acetyl-CoA synthetase (also known as acetate-CoA ligase and acetyl-activating enzyme); Region: ACS; cd05966 481805012716 active site 481805012717 CoA binding site [chemical binding]; other site 481805012718 acyl-activating enzyme (AAE) consensus motif; other site 481805012719 AMP binding site [chemical binding]; other site 481805012720 acetate binding site [chemical binding]; other site 481805012721 Predicted membrane protein [Function unknown]; Region: COG3162 481805012722 Predicted symporter [General function prediction only]; Region: DhlC; COG4147 481805012723 Uncharacterized bacterial solute carrier 5 subfamily; putative solute-binding domain; Region: SLC5sbd_u4; cd11480 481805012724 Na binding site [ion binding]; other site 481805012725 Pentapeptide repeats (9 copies); Region: Pentapeptide_4; pfam13599 481805012726 Pentapeptide repeats (8 copies); Region: Pentapeptide; pfam00805 481805012727 Na+/H+ antiporter, bacterial form; Region: a_cpa1; TIGR00831 481805012728 Kef-type K+ transport systems, membrane components [Inorganic ion transport and metabolism]; Region: KefB; cl10482 481805012729 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 481805012730 redox-sensitivie transcriptional activator SoxR; Provisional; Region: PRK15002 481805012731 Helix-Turn-Helix DNA binding domain of the SoxR transcription regulator; Region: HTH_SoxR; cd01110 481805012732 DNA binding residues [nucleotide binding] 481805012733 dimer interface [polypeptide binding]; other site 481805012734 [2Fe-2S] cluster binding site [ion binding]; other site 481805012735 DNA-binding transcriptional regulator SoxS; Provisional; Region: PRK10219 481805012736 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805012737 Predicted signal transduction protein containing sensor and EAL domains [Signal transduction mechanisms]; Region: COG4943 481805012738 CSS motif domain associated with EAL; Region: CSS-motif; pfam12792 481805012739 EAL domain. This domain is found in diverse bacterial signaling proteins. It is called EAL after its conserved residues and is also known as domain of unknown function 2 (DUF2). The EAL domain has been shown to stimulate degradation of a second...; Region: EAL; cd01948 481805012740 Single-stranded DNA-binding protein [DNA replication, recombination, and repair]; Region: Ssb; COG0629 481805012741 SSB_OBF: A subfamily of OB folds similar to the OB fold of ssDNA-binding protein (SSB). SSBs bind with high affinity to ssDNA. They bind to and protect ssDNA intermediates during DNA metabolic pathways. All bacterial and eukaryotic SSBs studied to date...; Region: SSB_OBF; cd04496 481805012742 dimer interface [polypeptide binding]; other site 481805012743 ssDNA binding site [nucleotide binding]; other site 481805012744 tetramer (dimer of dimers) interface [polypeptide binding]; other site 481805012745 Replication protein A, class 2b aminoacyl-tRNA synthetases, and related proteins with oligonucleotide/oligosaccharide (OB) fold; Region: RPA_2b-aaRSs_OBF_like; cl09930 481805012746 excinuclease ABC subunit A; Reviewed; Region: uvrA; PRK00349 481805012747 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 481805012748 ATP-binding cassette domain I of the excision repair protein UvrA; Region: ABC_UvrA_I; cd03270 481805012749 ATP-binding cassette domain II of the excision repair protein UvrA; Region: ABC_UvrA_II; cd03271 481805012750 Uncharacterized protein conserved in bacteria [Function unknown]; Region: MmcQ; COG2315 481805012751 secondary thiamine-phosphate synthase enzyme; Region: TIGR00149_YjbQ 481805012752 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805012753 active site 481805012754 motif I; other site 481805012755 motif II; other site 481805012756 aromatic amino acid aminotransferase; Provisional; Region: PRK09257 481805012757 Aspartate aminotransferase family. This family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). Pyridoxal phosphate combines with an alpha-amino acid to form a compound called a Schiff base or aldimine...; Region: AAT_like; cd00609 481805012758 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805012759 homodimer interface [polypeptide binding]; other site 481805012760 catalytic residue [active] 481805012761 alanine racemase; Reviewed; Region: alr; PRK00053 481805012762 Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes, Proteobacterial Alanine Racemases; Region: PLPDE_III_AR_proteobact; cd06827 481805012763 active site 481805012764 pyridoxal 5'-phosphate (PLP) binding site [chemical binding]; other site 481805012765 substrate binding site [chemical binding]; other site 481805012766 catalytic residues [active] 481805012767 dimer interface [polypeptide binding]; other site 481805012768 replicative DNA helicase; Provisional; Region: PRK08006 481805012769 DnaB-like helicase N terminal domain; Region: DnaB; pfam00772 481805012770 DnaB helicase C terminal domain. The hexameric helicase DnaB unwinds the DNA duplex at the chromosome replication fork. Although the mechanism by which DnaB both couples ATP hydrolysis to translocation along DNA and denatures the duplex is unknown, a...; Region: DnaB_C; cd00984 481805012771 Walker A motif; other site 481805012772 ATP binding site [chemical binding]; other site 481805012773 Walker B motif; other site 481805012774 DNA binding loops [nucleotide binding] 481805012775 quinone oxidoreductase, NADPH-dependent; Provisional; Region: PRK10754 481805012776 Quinone oxidoreductase (QOR); Region: QOR2; cd05286 481805012777 NADP binding site [chemical binding]; other site 481805012778 dimer interface [polypeptide binding]; other site 481805012779 phage shock protein G; Reviewed; Region: pspG; PRK09459 481805012780 tRNA-dihydrouridine synthase A; Provisional; Region: PRK11815 481805012781 Dihydrouridine synthase-like (DUS-like) FMN-binding domain. Members of this family catalyze the reduction of the 5,6-double bond of a uridine residue on tRNA. Dihydrouridine modification of tRNA is widely observed in prokaryotes and eukaryotes, and also...; Region: DUS_like_FMN; cd02801 481805012782 FMN binding site [chemical binding]; other site 481805012783 active site 481805012784 catalytic residues [active] 481805012785 substrate binding site [chemical binding]; other site 481805012786 Protein of unknown function (DUF2713); Region: DUF2713; pfam10897 481805012787 Ferric uptake regulator(Fur) and related metalloregulatory proteins; typically iron-dependent, DNA-binding repressors and activators; Region: Fur_like; cd07153 481805012788 metal binding site 2 [ion binding]; metal-binding site 481805012789 putative DNA binding helix; other site 481805012790 metal binding site 1 [ion binding]; metal-binding site 481805012791 dimer interface [polypeptide binding]; other site 481805012792 structural Zn2+ binding site [ion binding]; other site 481805012793 hypothetical protein; Provisional; Region: PRK10428 481805012794 DNA-damage-inducible SOS response protein; Provisional; Region: PRK10367 481805012795 DinF and similar proteins, a subfamily of the multidrug and toxic compound extrusion (MATE)-like proteins; Region: MATE_DinF_like; cd13136 481805012796 LexA repressor; Validated; Region: PRK00215 481805012797 LexA DNA binding domain; Region: LexA_DNA_bind; pfam01726 481805012798 Peptidase S24 LexA-like proteins are involved in the SOS response leading to the repair of single-stranded DNA within the bacterial cell. This family includes: the lambda repressor CI/C2 family and related bacterial prophage repressor proteins; LexA (EC...; Region: S24_LexA-like; cd06529 481805012799 Catalytic site [active] 481805012800 Diacylglycerol kinase [Cell envelope biogenesis, outer membrane]; Region: DgkA; COG0818 481805012801 glycerol-3-phosphate O-acyltransferase; Region: plsB; TIGR03703 481805012802 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: GPAT-like; Region: LPLAT_DHAPAT-like; cd07993 481805012803 putative acyl-acceptor binding pocket; other site 481805012804 4-hydroxybenzoate octaprenyltransferase; Reviewed; Region: ubiA; PRK12848 481805012805 UbiA prenyltransferase family; Region: UbiA; pfam01040 481805012806 chorismate pyruvate lyase; Provisional; Region: ubiC; PRK11655 481805012807 maltose regulon periplasmic protein; Provisional; Region: PRK10564 481805012808 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 481805012809 trimer interface; other site 481805012810 sugar binding site [chemical binding]; other site 481805012811 maltose/maltodextrin transporter ATP-binding protein; Provisional; Region: PRK11000 481805012812 The N-terminal ATPase domain of the maltose transporter, MalK; Region: ABC_MalK_N; cd03301 481805012813 Walker A/P-loop; other site 481805012814 ATP binding site [chemical binding]; other site 481805012815 Q-loop/lid; other site 481805012816 ABC transporter signature motif; other site 481805012817 Walker B; other site 481805012818 D-loop; other site 481805012819 H-loop/switch region; other site 481805012820 TOBE domain; Region: TOBE_2; pfam08402 481805012821 maltose ABC transporter periplasmic protein; Reviewed; Region: malE; PRK09474 481805012822 Domain of unknown function (DUF4179); Region: DUF4179; pfam13786 481805012823 Bacterial extracellular solute-binding protein; Region: SBP_bac_1; pfam01547 481805012824 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805012825 dimer interface [polypeptide binding]; other site 481805012826 conserved gate region; other site 481805012827 putative PBP binding loops; other site 481805012828 ABC-ATPase subunit interface; other site 481805012829 ABC-type sugar transport system, permease component [Carbohydrate transport and metabolism]; Region: UgpE; COG0395 481805012830 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805012831 dimer interface [polypeptide binding]; other site 481805012832 conserved gate region; other site 481805012833 putative PBP binding loops; other site 481805012834 ABC-ATPase subunit interface; other site 481805012835 D-xylose transporter XylE; Provisional; Region: xylE; PRK10077 481805012836 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805012837 putative substrate translocation pore; other site 481805012838 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805012839 phosphate-starvation-inducible protein PsiE; Provisional; Region: PRK02833 481805012840 Bacterial putative lipoprotein (DUF940); Region: DUF940; pfam06082 481805012841 Capsule biosynthesis GfcC; Region: Caps_synth_GfcC; pfam06251 481805012842 Protein of unknown function (DUF2886); Region: DUF2886; pfam11102 481805012843 glucose-6-phosphate isomerase; Reviewed; Region: pgi; PRK00179 481805012844 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the first SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_1; cd05015 481805012845 active site 481805012846 dimer interface [polypeptide binding]; other site 481805012847 Phosphoglucose isomerase (PGI) contains two SIS (Sugar ISomerase) domains. This classification is based on the alignment of the second SIS domain. PGI is a multifunctional enzyme which as an intracellular dimer catalyzes the reversible isomerization of...; Region: SIS_PGI_2; cd05016 481805012848 dimer interface [polypeptide binding]; other site 481805012849 active site 481805012850 aspartate kinase III; Validated; Region: PRK09084 481805012851 Amino Acid Kinases (AAK) superfamily, catalytic domain; present in such enzymes like N-acetylglutamate kinase (NAGK), carbamate kinase (CK), aspartokinase (AK), glutamate-5-kinase (G5K) and UMP kinase (UMPK). The AAK superfamily includes kinases that...; Region: AAK; cl00452 481805012852 nucleotide binding site [chemical binding]; other site 481805012853 substrate binding site [chemical binding]; other site 481805012854 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 481805012855 ACT domains located C-terminal to the catalytic domain of the lysine-sensitive aspartokinase isoenzyme AKIII; Region: ACT_AKiii-LysC-EC_2; cd04917 481805012856 dimer interface [polypeptide binding]; other site 481805012857 hypothetical protein; Provisional; Region: PRK10515 481805012858 23S rRNA pseudouridine synthase F; Provisional; Region: PRK10475 481805012859 S4/Hsp/ tRNA synthetase RNA-binding domain; The domain surface is populated by conserved, charged residues that define a likely RNA-binding site; Found in stress proteins, ribosomal proteins and tRNA synthetases; This may imply a hitherto unrecognized...; Region: S4; cd00165 481805012860 RNA binding surface [nucleotide binding]; other site 481805012861 Pseudouridine synthase, Escherichia coli RluF like; Region: PseudoU_synth_RluF; cd02554 481805012862 probable active site [active] 481805012863 Type 1 glutamine amidotransferase (GATase1)-like domain found in peptidase E; Region: GAT1_Peptidase_E; cd03146 481805012864 active site pocket [active] 481805012865 oxyanion hole [active] 481805012866 catalytic triad [active] 481805012867 active site nucleophile [active] 481805012868 Na+/phosphate symporter [Inorganic ion transport and metabolism]; Region: NptA; COG1283 481805012869 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 481805012870 Na+/Pi-cotransporter; Region: Na_Pi_cotrans; pfam02690 481805012871 B12-dependent methionine synthase; Provisional; Region: metH; PRK09490 481805012872 Methionine synthase I (cobalamin-dependent), methyltransferase domain [Amino acid transport and metabolism]; Region: MetH; COG0646 481805012873 MeTr subgroup of pterin binding enzymes. This family includes cobalamin-dependent methyltransferases such as methyltetrahydrofolate, corrinoid iron-sulfur protein methyltransferase (MeTr) and methionine synthase (MetH). Cobalamin-dependent...; Region: MeTr; cd00740 481805012874 substrate binding pocket [chemical binding]; other site 481805012875 B12 binding domain of methionine synthase. This domain binds methylcobalamin, which it uses as an intermediate methyl carrier from methyltetrahydrofolate (CH3H4folate) to homocysteine (Hcy); Region: methionine_synthase_B12_BD; cd02069 481805012876 B12 binding site [chemical binding]; other site 481805012877 cobalt ligand [ion binding]; other site 481805012878 Vitamin B12 dependent methionine synthase, activation domain; Region: Met_synt_B12; pfam02965 481805012879 transcriptional repressor IclR; Provisional; Region: PRK11569 481805012880 helix_turn_helix isocitrate lyase regulation; Region: HTH_ICLR; smart00346 481805012881 Bacterial transcriptional regulator; Region: IclR; pfam01614 481805012882 ShET2 enterotoxin, N-terminal region; Region: Toxin_15; pfam07906 481805012883 Isocitrate dehydrogenase kinase/phosphatase [Signal transduction mechanisms]; Region: COG4579 481805012884 bifunctional isocitrate dehydrogenase kinase/phosphatase protein; Validated; Region: aceK; PRK02946 481805012885 isocitrate lyase; Provisional; Region: PRK15063 481805012886 Members of the ICL/PEPM enzyme family catalyze either P-C or C-C bond formation/cleavage. Known members are phosphoenolpyruvate mutase (PEPM), phosphonopyruvate hydrolase (PPH), carboxyPEP mutase (CPEP mutase), oxaloacetate hydrolase (OAH), isocitrate...; Region: ICL_PEPM; cd00377 481805012887 tetramer interface [polypeptide binding]; other site 481805012888 active site 481805012889 Mg2+/Mn2+ binding site [ion binding]; other site 481805012890 Malate synthase A (MSA), present in some bacteria, plants and fungi. Prokaryotic MSAs tend to be monomeric, whereas eukaryotic enzymes are homomultimers. In general, malate synthase catalyzes the Claisen condensation of glyoxylate and acetyl-CoA to...; Region: malate_synt_A; cd00727 481805012891 malate synthase A; Region: malate_syn_A; TIGR01344 481805012892 active site 481805012893 homoserine O-succinyltransferase; Provisional; Region: PRK05368 481805012894 Type 1 glutamine amidotransferase (GATase1)-like domain found in homoserine trans-succinylase (HTS); Region: GATase1_HTS; cd03131 481805012895 proposed active site lysine [active] 481805012896 conserved cys residue [active] 481805012897 Acetyltransferase (GNAT) domain; Region: Acetyltransf_10; pfam13673 481805012898 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481805012899 Coenzyme A binding pocket [chemical binding]; other site 481805012900 bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Provisional; Region: purH; PRK00881 481805012901 Inosine monophosphate cyclohydrolase domain. This is the N-terminal domain in the purine biosynthesis pathway protein ATIC (purH). The bifunctional ATIC protein contains a C-terminal ATIC formylase domain that formylates...; Region: IMPCH; cd01421 481805012902 purine monophosphate binding site [chemical binding]; other site 481805012903 dimer interface [polypeptide binding]; other site 481805012904 putative catalytic residues [active] 481805012905 AICARFT/IMPCHase bienzyme; Region: AICARFT_IMPCHas; smart00798 481805012906 phosphoribosylamine--glycine ligase; Provisional; Region: PRK00885 481805012907 Phosphoribosylglycinamide synthetase, N domain; Region: GARS_N; pfam02844 481805012908 Phosphoribosylglycinamide synthetase, ATP-grasp (A) domain; Region: GARS_A; pfam01071 481805012909 Phosphoribosylglycinamide synthetase, C domain; Region: GARS_C; pfam02843 481805012910 transcriptional regulatory protein ZraR; Provisional; Region: PRK10365 481805012911 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805012912 active site 481805012913 phosphorylation site [posttranslational modification] 481805012914 intermolecular recognition site; other site 481805012915 dimerization interface [polypeptide binding]; other site 481805012916 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805012917 Walker A motif; other site 481805012918 ATP binding site [chemical binding]; other site 481805012919 Walker B motif; other site 481805012920 arginine finger; other site 481805012921 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 481805012922 sensor protein ZraS; Provisional; Region: PRK10364 481805012923 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805012924 dimer interface [polypeptide binding]; other site 481805012925 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805012926 ATP binding site [chemical binding]; other site 481805012927 Mg2+ binding site [ion binding]; other site 481805012928 G-X-G motif; other site 481805012929 zinc resistance protein; Provisional; Region: zraP; PRK11546 481805012930 dimer interface [polypeptide binding]; other site 481805012931 Protein of unknown function (DUF1481); Region: DUF1481; pfam07356 481805012932 Integration host factor (IHF) and HU are small heterodimeric members of the DNABII protein family that bind and bend DNA, functioning as architectural factors in many cellular processes including transcription, site-specific recombination, and...; Region: HU_IHF; cd00591 481805012933 IHF dimer interface [polypeptide binding]; other site 481805012934 IHF - DNA interface [nucleotide binding]; other site 481805012935 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3068 481805012936 Endonuclease_V, a DNA repair enzyme that initiates repair of nitrosative deaminated purine bases; Region: Endonuclease_V; cd06559 481805012937 Active_site [active] 481805012938 Uroporphyrinogen decarboxylase (URO-D) is a dimeric cytosolic enzyme that decarboxylates the four acetate side chains of uroporphyrinogen III (uro-III) to create coproporphyrinogen III, without requiring any prosthetic groups or cofactors. This reaction...; Region: URO-D; cd00717 481805012939 substrate binding site [chemical binding]; other site 481805012940 active site 481805012941 NADH pyrophosphatase; Reviewed; Region: nudC; PRK00241 481805012942 NADH pyrophosphatase-like rudimentary NUDIX domain; Region: NUDIX-like; pfam09296 481805012943 NADH pyrophosphatase zinc ribbon domain; Region: zf-NADH-PPase; pfam09297 481805012944 NADH pyrophosphatase, a member of the Nudix hydrolase superfamily, catalyzes the cleavage of NADH into reduced nicotinamide mononucleotide (NMNH) and AMP. Like other members of the Nudix family, it requires a divalent cation, such as Mg2+ or Mn2+, for...; Region: NADH_pyrophosphatase; cd03429 481805012945 putative NADH binding site [chemical binding]; other site 481805012946 putative active site [active] 481805012947 nudix motif; other site 481805012948 putative metal binding site [ion binding]; other site 481805012949 Regulator of sigma D [Transcription]; Region: Rsd; COG3160 481805012950 thiamine biosynthesis protein ThiC; Provisional; Region: PRK09284 481805012951 ThiC-associated domain; Region: ThiC-associated; pfam13667 481805012952 Thiamine biosynthesis protein ThiC [Coenzyme metabolism]; Region: ThiC; COG0422 481805012953 Thiamine monophosphate synthase (TMP synthase)/TenI. TMP synthase catalyzes an important step in the thiamine biosynthesis pathway, the substitution of the pyrophosphate of 2-methyl-4-amino-5- hydroxymethylpyrimidine pyrophosphate by 4-methyl-5-; Region: TMP_TenI; cd00564 481805012954 thiamine phosphate binding site [chemical binding]; other site 481805012955 active site 481805012956 pyrophosphate binding site [ion binding]; other site 481805012957 ThiF_MoeB_HesA. Family of E1-like enzymes involved in molybdopterin and thiamine biosynthesis family. The common reaction mechanism catalyzed by MoeB and ThiF, like other E1 enzymes, begins with a nucleophilic attack of the C-terminal carboxylate of MoaD...; Region: ThiF_MoeB_HesA_family; cd00757 481805012958 thiazole biosynthesis adenylyltransferase ThiF, E. coli subfamily; Region: adenyl_thiF; TIGR02356 481805012959 ATP binding site [chemical binding]; other site 481805012960 substrate interface [chemical binding]; other site 481805012961 ThiaminS ubiquitin-like sulfur carrier protein; Region: ThiS; cd00565 481805012962 thiS-thiF/thiG interaction site; other site 481805012963 Thiazole synthase (ThiG) is the tetrameric enzyme that is involved in the formation of the thiazole moiety of thiamin pyrophosphate, an essential ubiquitous cofactor that plays an important role in carbohydrate and amino acid metabolism. ThiG catalyzes...; Region: ThiG; cd04728 481805012964 ThiS interaction site; other site 481805012965 putative active site [active] 481805012966 tetramer interface [polypeptide binding]; other site 481805012967 thiamine biosynthesis protein ThiH; Reviewed; Region: thiH; PRK09240 481805012968 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805012969 FeS/SAM binding site; other site 481805012970 Biotin and Thiamin Synthesis associated domain; Region: BATS; pfam06968 481805012971 RNA polymerase Rpb1, domain 1; Region: RNA_pol_Rpb1_1; pfam04997 481805012972 DNA-directed RNA polymerase, beta' subunit/160 kD subunit [Transcription]; Region: RpoC; COG0086 481805012973 RNA polymerase I subunit A N-terminus; Region: RPOLA_N; smart00663 481805012974 RNA polymerase Rpb1, domain 3; Region: RNA_pol_Rpb1_3; pfam04983 481805012975 RNA polymerase Rpb1, domain 4; Region: RNA_pol_Rpb1_4; pfam05000 481805012976 RNA polymerase Rpb1, domain 5; Region: RNA_pol_Rpb1_5; pfam04998 481805012977 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 481805012978 Rpb1 - Rpb6 interaction site [polypeptide binding]; other site 481805012979 Largest subunit of RNA polymerase (RNAP), C-terminal domain; Region: RNAP_largest_subunit_C; cl11429 481805012980 Largest subunit (beta') of Bacterial DNA-dependent RNA polymerase (RNAP), C-terminal domain; Region: RNAP_beta'_C; cd02655 481805012981 DNA binding site [nucleotide binding] 481805012982 Rpb1 (beta') - Rpb2 (beta) interaction site [polypeptide binding]; other site 481805012983 DNA-directed RNA polymerase subunit beta; Reviewed; Region: rpoB; PRK00405 481805012984 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cl17585 481805012985 RNA polymerase Rpb2, domain 2; Region: RNA_pol_Rpb2_2; pfam04561 481805012986 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 481805012987 RNA polymerase Rpb2, domain 6; Region: RNA_pol_Rpb2_6; pfam00562 481805012988 RNA polymerase beta subunit. RNA polymerases catalyse the DNA dependent polymerization of RNA. Prokaryotes contain a single RNA polymerase compared to three in eukaryotes (not including mitochondrial. and chloroplast polymerases). Each RNA polymerase...; Region: RNA_pol_B_RPB2; cd00653 481805012989 RPB3 interaction site [polypeptide binding]; other site 481805012990 RPB1 interaction site [polypeptide binding]; other site 481805012991 RPB11 interaction site [polypeptide binding]; other site 481805012992 RPB10 interaction site [polypeptide binding]; other site 481805012993 Ribosomal protein L7/L12. Ribosomal protein L7/L12 refers to the large ribosomal subunit proteins L7 and L12, which are identical except that L7 is acetylated at the N terminus. It is a component of the L7/L12 stalk, which is located at the surface of...; Region: Ribosomal_L7_L12; cd00387 481805012994 core dimer interface [polypeptide binding]; other site 481805012995 peripheral dimer interface [polypeptide binding]; other site 481805012996 L10 interface [polypeptide binding]; other site 481805012997 L11 interface [polypeptide binding]; other site 481805012998 putative EF-Tu interaction site [polypeptide binding]; other site 481805012999 putative EF-G interaction site [polypeptide binding]; other site 481805013000 Ribosomal protein L10 family, L10 subfamily; composed of bacterial 50S ribosomal protein and eukaryotic mitochondrial 39S ribosomal protein, L10. L10 occupies the L7/L12 stalk of the ribosome. The N-terminal domain (NTD) of L10 interacts with L11 protein...; Region: Ribosomal_L10; cd05797 481805013001 23S rRNA interface [nucleotide binding]; other site 481805013002 Interface with L7/L12 ribosomal proteins [polypeptide binding]; other site 481805013003 Ribosomal protein L1. The L1 protein, located near the E-site of the ribosome, forms part of the L1 stalk along with 23S rRNA. In bacteria and archaea, L1 functions both as a ribosomal protein that binds rRNA, and as a translation repressor that binds...; Region: Ribosomal_L1; cd00403 481805013004 mRNA/rRNA interface [nucleotide binding]; other site 481805013005 50S ribosomal protein L11; Validated; Region: rplK; PRK00140 481805013006 Ribosomal protein L11. Ribosomal protein L11, together with proteins L10 and L7/L12, and 23S rRNA, form the L7/L12 stalk on the surface of the large subunit of the ribosome. The homologous eukaryotic cytoplasmic protein is also called 60S ribosomal...; Region: Ribosomal_L11; cd00349 481805013007 23S rRNA interface [nucleotide binding]; other site 481805013008 L7/L12 interface [polypeptide binding]; other site 481805013009 putative thiostrepton binding site; other site 481805013010 L25 interface [polypeptide binding]; other site 481805013011 transcription antitermination protein NusG; Validated; Region: nusG; PRK05609 481805013012 Bacterial N-Utilization Substance G (NusG) N-terminal (NGN) domain, subgroup 1; Region: NGN_Bact_1; cd09891 481805013013 putative homodimer interface [polypeptide binding]; other site 481805013014 NusG contains an NGN domain at its N-terminus and KOW motif at its C-terminus; Region: KOW_NusG; cd06091 481805013015 heterodimer interface [polypeptide binding]; other site 481805013016 homodimer interface [polypeptide binding]; other site 481805013017 preprotein translocase subunit SecE; Reviewed; Region: secE; PRK05740 481805013018 elongation factor Tu; Reviewed; Region: PRK00049 481805013019 Elongation Factor Tu (EF-Tu) GTP-binding proteins; Region: EF_Tu; cd01884 481805013020 G1 box; other site 481805013021 GEF interaction site [polypeptide binding]; other site 481805013022 GTP/Mg2+ binding site [chemical binding]; other site 481805013023 Switch I region; other site 481805013024 G2 box; other site 481805013025 G3 box; other site 481805013026 Switch II region; other site 481805013027 G4 box; other site 481805013028 G5 box; other site 481805013029 EFTU_II: Elongation factor Tu domain II. Elongation factors Tu (EF-Tu) are three-domain GTPases with an essential function in the elongation phase of mRNA translation. The GTPase center of EF-Tu is in the N-terminal domain (domain I), also known as the...; Region: EFTU_II; cd03697 481805013030 Domain III of elongation factor (EF) Tu. Ef-Tu consists of three structural domains, designated I, II and III. Domain III adopts a beta barrel structure. Domain III is involved in binding to both charged tRNA and binding to elongation factor Ts (EF-Ts); Region: EFTU_III; cd03707 481805013031 Antibiotic Binding Site [chemical binding]; other site 481805013032 pantothenate kinase; Provisional; Region: PRK05439 481805013033 Pantothenate kinase (PanK) catalyzes the phosphorylation of pantothenic acid to form 4'-phosphopantothenic, which is the first of five steps in coenzyme A (CoA) biosynthetic pathway. The reaction carried out by this enzyme is a key regulatory point...; Region: PanK; cd02025 481805013034 ATP-binding site [chemical binding]; other site 481805013035 CoA-binding site [chemical binding]; other site 481805013036 Mg2+-binding site [ion binding]; other site 481805013037 Biotin operon repressor [Transcription]; Region: BirA; COG1654 481805013038 bifunctional biotin--[acetyl-CoA-carboxylase] synthetase/biotin operon repressor; Provisional; Region: PRK11886 481805013039 Biotin/lipoate A/B protein ligase family; Region: BPL_LplA_LipB; pfam03099 481805013040 Biotin protein ligase C terminal domain; Region: BPL_C; pfam02237 481805013041 UDP-N-acetylenolpyruvoylglucosamine reductase; Provisional; Region: murB; PRK00046 481805013042 FAD binding domain; Region: FAD_binding_4; pfam01565 481805013043 UDP-N-acetylenolpyruvoylglucosamine reductase, C-terminal domain; Region: MurB_C; pfam02873 481805013044 glutamate racemase; Provisional; Region: PRK00865 481805013045 vitamin B12/cobalamin outer membrane transporter; Provisional; Region: btuB; PRK10641 481805013046 TonB dependent/Ligand-Gated channels are created by a monomeric 22 strand (22,24) anti-parallel beta-barrel. Ligands apparently bind to the large extracellular loops. The N-terminal 150-200 residues form a plug from the periplasmic end of barrel; Region: ligand_gated_channel; cd01347 481805013047 N-terminal plug; other site 481805013048 ligand-binding site [chemical binding]; other site 481805013049 tRNA (uracil-5-)-methyltransferase; Validated; Region: PRK05031 481805013050 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805013051 S-adenosylmethionine binding site [chemical binding]; other site 481805013052 hypothetical protein; Provisional; Region: PRK11056 481805013053 DNA-binding transcriptional repressor FabR; Provisional; Region: PRK11202 481805013054 Bacterial regulatory proteins, tetR family; Region: TetR_N; pfam00440 481805013055 soluble pyridine nucleotide transhydrogenase; Provisional; Region: PRK05249 481805013056 Pyridine nucleotide-disulphide oxidoreductase; Region: Pyr_redox; pfam00070 481805013057 Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain; Region: Pyr_redox_dim; pfam02852 481805013058 DNA-binding transcriptional regulator OxyR; Provisional; Region: PRK11151 481805013059 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805013060 The C-terminal substrate-binding domain of the LysR-type transcriptional regulator OxyR, a member of the type 2 periplasmic binding fold protein superfamily; Region: PBP2_OxyR; cd08411 481805013061 dimerization interface [polypeptide binding]; other site 481805013062 argininosuccinate lyase; Provisional; Region: PRK04833 481805013063 Argininosuccinate lyase (argininosuccinase, ASAL); Region: Argininosuccinate_lyase; cd01359 481805013064 active sites [active] 481805013065 tetramer interface [polypeptide binding]; other site 481805013066 AAK_NAGK-NC: N-Acetyl-L-glutamate kinase - noncyclic (NAGK-NC) catalyzes the phosphorylation of the gamma-COOH group of N-acetyl-L-glutamate (NAG) by ATP in the second step of microbial arginine biosynthesis using the acetylated, noncyclic route of...; Region: AAK_NAGK-NC; cd04249 481805013067 nucleotide binding site [chemical binding]; other site 481805013068 N-acetyl-L-glutamate binding site [chemical binding]; other site 481805013069 N-acetyl-gamma-glutamyl-phosphate reductase; Validated; Region: argC; PRK00436 481805013070 Semialdehyde dehydrogenase, NAD binding domain; Region: Semialdhyde_dh; smart00859 481805013071 acetylornithine deacetylase; Provisional; Region: PRK05111 481805013072 M20 Peptidase acetylornithine deacetylase; Region: M20_ArgE; cd03894 481805013073 metal binding site [ion binding]; metal-binding site 481805013074 putative dimer interface [polypeptide binding]; other site 481805013075 phosphoenolpyruvate carboxylase; Reviewed; Region: PRK00009 481805013076 Phosphoenolpyruvate carboxylase [Energy production and conversion]; Region: Ppc; COG2352 481805013077 hypothetical protein; Provisional; Region: PRK10649 481805013078 Domain of unknown function (DUF1705); Region: DUF1705; pfam08019 481805013079 Sulfatase; Region: Sulfatase; pfam00884 481805013080 helix_turn_helix, arabinose operon control protein; Region: HTH_ARAC; smart00342 481805013081 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805013082 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 481805013083 active site 481805013084 P-loop; other site 481805013085 phosphorylation site [posttranslational modification] 481805013086 pyruvate formate lyase II activase; Provisional; Region: PRK10076 481805013087 putative formate acetyltransferase 2; Provisional; Region: pflD; PRK09983 481805013088 Pyruvate formate lyase 2 and related enzymes; Region: PFL2_DhaB_BssA; cd01677 481805013089 dimer interface [polypeptide binding]; other site 481805013090 active site 481805013091 glycine loop; other site 481805013092 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 481805013093 active site 481805013094 P-loop; other site 481805013095 phosphorylation site [posttranslational modification] 481805013096 putative PTS system fructose-like transporter subunit EIIC; Provisional; Region: PRK10478 481805013097 Phosphotransferase system, EIIC; Region: PTS_EIIC; pfam02378 481805013098 Histidine-containing phosphocarrier protein (HPr)-like proteins. HPr is a central component of the bacterial phosphoenolpyruvate sugar phosphotransferase system (PTS). The PTS catalyses the phosphorylation of sugar substrates during their translocation...; Region: PTS-HPr_like; cd00367 481805013099 dimerization domain swap beta strand [polypeptide binding]; other site 481805013100 regulatory protein interface [polypeptide binding]; other site 481805013101 active site 481805013102 regulatory phosphorylation site [posttranslational modification]; other site 481805013103 PEP-utilising enzyme, N-terminal; Region: PEP-utilisers_N; pfam05524 481805013104 Phosphoenolpyruvate-protein kinase (PTS system EI component in bacteria) [Carbohydrate transport and metabolism]; Region: PtsA; COG1080 481805013105 PEP-utilising enzyme, mobile domain; Region: PEP-utilizers; pfam00391 481805013106 PEP-utilising enzyme, TIM barrel domain; Region: PEP-utilizers_C; pfam02896 481805013107 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481805013108 active site 481805013109 phosphorylation site [posttranslational modification] 481805013110 Transaldolase-like fructose-6-phosphate aldolases (FSA) found in bacteria and archaea; Region: Transaldolase_FSA; cd00956 481805013111 active site 481805013112 intersubunit interactions; other site 481805013113 catalytic residue [active] 481805013114 Glycerol dehydrogenase and related enzymes [Energy production and conversion]; Region: GldA; COG0371 481805013115 Glycerol dehydrogenases (GlyDH) catalyzes oxidation of glycerol to dihydroxyacetone in glycerol dissmilation; Region: GlyDH; cd08170 481805013116 dimer interface [polypeptide binding]; other site 481805013117 active site 481805013118 metal binding site [ion binding]; metal-binding site 481805013119 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3738 481805013120 EamA-like transporter family; Region: EamA; pfam00892 481805013121 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 481805013122 EamA-like transporter family; Region: EamA; pfam00892 481805013123 catalase/hydroperoxidase HPI(I); Provisional; Region: PRK15061 481805013124 Heme-dependent peroxidases similar to plant peroxidases; Region: plant_peroxidase_like; cl00196 481805013125 heme binding site [chemical binding]; other site 481805013126 C-terminal non-catalytic domain of catalase-peroxidases; Region: catalase_peroxidase_2; cd08200 481805013127 Methylenetetrahydrofolate reductase (MTHFR). 5,10-Methylenetetrahydrofolate is reduced to 5-methyltetrahydrofolate by methylenetetrahydrofolate reductase, a cytoplasmic, NAD(P)-dependent enzyme. 5-methyltetrahydrofolate is utilized by methionine synthase...; Region: MTHFR; cd00537 481805013128 FAD binding site [chemical binding]; other site 481805013129 bifunctional aspartate kinase II/homoserine dehydrogenase II; Provisional; Region: metL; PRK09466 481805013130 AAK_AK-HSDH: Amino Acid Kinase Superfamily (AAK), AK-HSDH; this CD includes the N-terminal catalytic domain of aspartokinase (AK) of the bifunctional enzyme AK - homoserine dehydrogenase (HSDH). These aspartokinases are found in bacteria (E. coli...; Region: AAK_AK-HSDH; cd04257 481805013131 putative catalytic residues [active] 481805013132 putative nucleotide binding site [chemical binding]; other site 481805013133 putative aspartate binding site [chemical binding]; other site 481805013134 ACT domains are commonly involved in specifically binding an amino acid or other small ligand leading to regulation of the enzyme; Region: ACT; cl09141 481805013135 Homoserine dehydrogenase, NAD binding domain; Region: NAD_binding_3; pfam03447 481805013136 Homoserine dehydrogenase; Region: Homoserine_dh; pfam00742 481805013137 cystathionine gamma-synthase; Provisional; Region: PRK08045 481805013138 CGS_like: Cystathionine gamma-synthase is a PLP dependent enzyme and catalyzes the committed step of methionine biosynthesis. This pathway is unique to microorganisms and plants, rendering the enzyme an attractive target for the development of...; Region: CGS_like; cd00614 481805013139 homodimer interface [polypeptide binding]; other site 481805013140 substrate-cofactor binding pocket; other site 481805013141 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805013142 catalytic residue [active] 481805013143 Met Repressor, MetJ. MetJ is a bacterial regulatory protein that uses S-adenosylmethionine (SAM) as a corepressor to regulate the production of Methionine. MetJ binds arrays of two to five adjacent copies of an eight base-pair 'metbox'...; Region: Met_repressor_MetJ; cd00490 481805013144 dimerization interface [polypeptide binding]; other site 481805013145 DNA binding site [nucleotide binding] 481805013146 corepressor binding sites; other site 481805013147 hypothetical protein; Provisional; Region: PRK10030 481805013148 Transposase and inactivated derivatives [DNA replication, recombination, and repair]; Region: COG3677 481805013149 InsA N-terminal domain; Region: Zn_Tnp_IS1; pfam03811 481805013150 InsA C-terminal domain; Region: HTH_Tnp_IS1; pfam12759 481805013151 PAAR motif; Region: PAAR_motif; cl15808 481805013152 Rhs family protein [Cell envelope biogenesis, outer membrane]; Region: RhsA; COG3209 481805013153 RHS Repeat; Region: RHS_repeat; pfam05593 481805013154 RHS repeat-associated core domain; Region: Rhs_assc_core; TIGR03696 481805013155 Domain of unknown function (DUF4329); Region: DUF4329; pfam14220 481805013156 50S ribosomal protein L31; Reviewed; Region: rpmE; PRK00019 481805013157 primosome assembly protein PriA; Validated; Region: PRK05580 481805013158 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481805013159 ATP binding site [chemical binding]; other site 481805013160 putative Mg++ binding site [ion binding]; other site 481805013161 helicase superfamily c-terminal domain; Region: HELICc; smart00490 481805013162 ATP-binding site [chemical binding]; other site 481805013163 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481805013164 DNA binding site [nucleotide binding] 481805013165 DNA-binding transcriptional regulator CytR; Provisional; Region: PRK11041 481805013166 domain linker motif; other site 481805013167 Ligand-binding domain of an uncharacterized transcription regulator from Actinobacillus succinogenes and its close homologs from other bacteria; Region: PBP1_LacI_like_6; cd06284 481805013168 dimerization interface [polypeptide binding]; other site 481805013169 ligand binding site [chemical binding]; other site 481805013170 essential cell division protein FtsN; Provisional; Region: PRK10927 481805013171 cell division protein FtsN; Provisional; Region: PRK12757 481805013172 Protease HslV and the ATPase/chaperone HslU are part of an ATP-dependent proteolytic system that is the prokaryotic homolog of the proteasome. HslV is a dimer of hexamers (a dodecamer) that forms a central proteolytic chamber with active sites on the...; Region: protease_HslV; cd01913 481805013173 active site 481805013174 HslU subunit interaction site [polypeptide binding]; other site 481805013175 ATP-dependent protease ATP-binding subunit HslU; Provisional; Region: hslU; PRK05201 481805013176 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805013177 Walker A motif; other site 481805013178 ATP binding site [chemical binding]; other site 481805013179 AAA domain (Cdc48 subfamily); Region: AAA_2; pfam07724 481805013180 C-terminal, D2-small domain, of ClpB protein; Region: ClpB_D2-small; smart01086 481805013181 1,4-dihydroxy-2-naphthoate octaprenyltransferase; Region: menA; TIGR00751 481805013182 UbiA prenyltransferase family; Region: UbiA; pfam01040 481805013183 ribonuclease activity regulator protein RraA; Provisional; Region: PRK09372 481805013184 septal ring assembly protein ZapB; Provisional; Region: PRK15422 481805013185 Major intrinsic protein (MIP) superfamily. Members of the MIP superfamily function as membrane channels that selectively transport water, small neutral molecules, and ions out of and between cells. The channel proteins share a common fold: the N-terminal...; Region: MIP; cd00333 481805013186 amphipathic channel; other site 481805013187 Asn-Pro-Ala signature motifs; other site 481805013188 glycerol kinase; Provisional; Region: glpK; PRK00047 481805013189 Escherichia coli glycerol kinase-like proteins; belongs to the FGGY family of carbohydrate kinases; Region: FGGY_EcGK_like; cd07786 481805013190 N- and C-terminal domain interface [polypeptide binding]; other site 481805013191 active site 481805013192 MgATP binding site [chemical binding]; other site 481805013193 catalytic site [active] 481805013194 metal binding site [ion binding]; metal-binding site 481805013195 glycerol binding site [chemical binding]; other site 481805013196 homotetramer interface [polypeptide binding]; other site 481805013197 homodimer interface [polypeptide binding]; other site 481805013198 FBP binding site [chemical binding]; other site 481805013199 protein IIAGlc interface [polypeptide binding]; other site 481805013200 Bacterial fructose-1,6-bisphosphatase, glpX-encoded; Region: FBPase_glpX; pfam03320 481805013201 Bacterial fructose-1,6-bisphosphatase, glpX-encoded. A dimeric enzyme dependent on Mg(2+). glpX-encoded FPBase (FBPase class II) differs from other members of the inositol-phosphatase superfamily by permutation of secondary structure elements. The core...; Region: FBPase_glpX; cd01516 481805013202 putative active site [active] 481805013203 ferredoxin-NADP reductase; Provisional; Region: PRK10926 481805013204 Ferredoxin-NADP+ (oxido)reductase is an FAD-containing enzyme that catalyzes the reversible electron transfer between NADP(H) and electron carrier proteins such as ferredoxin and flavodoxin. Isoforms of these flavoproteins (i.e. having a non-covalently...; Region: FNR1; cd06195 481805013205 FAD binding pocket [chemical binding]; other site 481805013206 FAD binding motif [chemical binding]; other site 481805013207 phosphate binding motif [ion binding]; other site 481805013208 beta-alpha-beta structure motif; other site 481805013209 NAD binding pocket [chemical binding]; other site 481805013210 Usp: Universal stress protein family. The universal stress protein Usp is a small cytoplasmic bacterial protein whose expression is enhanced when the cell is exposed to stress agents. Usp enhances the rate of cell survival during prolonged exposure to...; Region: USP_Like; cd00293 481805013211 Ligand Binding Site [chemical binding]; other site 481805013212 hypothetical protein; Provisional; Region: PRK09981 481805013213 Predicted membrane protein [Function unknown]; Region: COG3152 481805013214 Protein of unknown function (DUF1454); Region: DUF1454; pfam07305 481805013215 Triosephosphate isomerase (TIM) is a glycolytic enzyme that catalyzes the interconversion of dihydroxyacetone phosphate and D-glyceraldehyde-3-phosphate. The reaction is very efficient and requires neither cofactors nor metal ions. TIM, usually...; Region: TIM; cd00311 481805013216 triosephosphate isomerase; Provisional; Region: PRK14567 481805013217 substrate binding site [chemical binding]; other site 481805013218 dimer interface [polypeptide binding]; other site 481805013219 catalytic triad [active] 481805013220 CDP-diacylglycerol pyrophosphatase, bacterial type; Region: cdh; TIGR00672 481805013221 sulfate transporter subunit; Provisional; Region: PRK10752 481805013222 Bacterial extracellular solute-binding protein; Region: SBP_bac_11; pfam13531 481805013223 Phosphofructokinase, a key regulatory enzyme in glycolysis, catalyzes the phosphorylation of fructose-6-phosphate to fructose-1,6-biphosphate. The members belong to a subfamily of the PFKA family (cd00363) and include bacterial ATP-dependent...; Region: Bacterial_PFK; cd00763 481805013224 6-phosphofructokinase; Region: PFKA_ATP; TIGR02482 481805013225 active site 481805013226 ADP/pyrophosphate binding site [chemical binding]; other site 481805013227 dimerization interface [polypeptide binding]; other site 481805013228 allosteric effector site; other site 481805013229 fructose-1,6-bisphosphate binding site; other site 481805013230 ferrous iron efflux protein F; Reviewed; Region: fieF; PRK09509 481805013231 Predicted Co/Zn/Cd cation transporters [Inorganic ion transport and metabolism]; Region: MMT1; COG0053 481805013232 CpxP component of the bacterial Cpx-two-component system and related proteins; Region: CpxP_like; cd09916 481805013233 dimer interface [polypeptide binding]; other site 481805013234 DNA-binding transcriptional regulator CpxR; Provisional; Region: PRK10955 481805013235 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805013236 active site 481805013237 intermolecular recognition site; other site 481805013238 dimerization interface [polypeptide binding]; other site 481805013239 Effector domain of response regulator. Bacteria and certain eukaryotes like protozoa and higher plants use two-component signal transduction systems to detect and respond to changes in the environment. The system consists of a sensor histidine kinase and...; Region: trans_reg_C; cd00383 481805013240 DNA binding site [nucleotide binding] 481805013241 two-component sensor protein; Provisional; Region: cpxA; PRK09470 481805013242 Histidine kinase, Adenylyl cyclase, Methyl-accepting protein, and Phosphatase (HAMP) domain. HAMP is a signaling domain which occurs in a wide variety of signaling proteins, many of which are bacterial. The HAMP domain consists of two alpha helices...; Region: HAMP; cd06225 481805013243 dimerization interface [polypeptide binding]; other site 481805013244 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805013245 dimer interface [polypeptide binding]; other site 481805013246 phosphorylation site [posttranslational modification] 481805013247 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805013248 ATP binding site [chemical binding]; other site 481805013249 Mg2+ binding site [ion binding]; other site 481805013250 G-X-G motif; other site 481805013251 6-N-hydroxylaminopurine resistance protein; Provisional; Region: PRK11536 481805013252 MOSC domain; Region: MOSC; pfam03473 481805013253 3-alpha domain; Region: 3-alpha; pfam03475 481805013254 2-keto-3-deoxygluconate transporter; Region: kdgT; TIGR00793 481805013255 superoxide dismutase; Provisional; Region: PRK10925 481805013256 Iron/manganese superoxide dismutases, alpha-hairpin domain; Region: Sod_Fe_N; pfam00081 481805013257 Iron/manganese superoxide dismutases, C-terminal domain; Region: Sod_Fe_C; pfam02777 481805013258 L-rhamnose-proton symport protein (RhaT); Region: RhaT; cl05728 481805013259 RhaT L-rhamnose-proton symporter family protein; Region: RhaT; TIGR00776 481805013260 transcriptional activator RhaR; Provisional; Region: PRK13500 481805013261 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481805013262 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805013263 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805013264 transcriptional activator RhaS; Provisional; Region: PRK13503 481805013265 AraC-like ligand binding domain; Region: AraC_binding; pfam02311 481805013266 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805013267 Bacterial regulatory helix-turn-helix proteins, AraC family; Region: HTH_AraC; pfam00165 481805013268 L-rhamnulose kinases; a subfamily of the FGGY family of carbohydrate kinases; Region: FGGY_RhuK; cd07771 481805013269 N- and C-terminal domain interface [polypeptide binding]; other site 481805013270 active site 481805013271 putative catalytic site [active] 481805013272 metal binding site [ion binding]; metal-binding site 481805013273 ATP binding site [chemical binding]; other site 481805013274 rhamnulokinase; Provisional; Region: rhaB; PRK10640 481805013275 carbohydrate binding site [chemical binding]; other site 481805013276 L-rhamnose isomerase; Provisional; Region: PRK01076 481805013277 Predicted sugar isomerase [Cell envelope biogenesis, outer membrane]; Region: COG4952; cl17900 481805013278 Class II Aldolase and Adducin head (N-terminal) domain. Aldolases are ubiquitous enzymes catalyzing central steps of carbohydrate metabolism. Based on enzymatic mechanisms, this superfamily has been divided into two distinct classes (Class I and II); Region: Aldolase_II; cd00398 481805013279 intersubunit interface [polypeptide binding]; other site 481805013280 active site 481805013281 Zn2+ binding site [ion binding]; other site 481805013282 L-rhamnose 1-epimerase; Region: YiiL_rotase; TIGR02625 481805013283 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481805013284 active site 481805013285 phosphorylation site [posttranslational modification] 481805013286 putative PTS system transporter subunits IIBC; Provisional; Region: PRK11404 481805013287 PTS_IIB_fructose: subunit IIB of enzyme II (EII) of the fructose-specific phosphoenolpyruvate:carbohydrate phosphotransferase system (PTS). In this system, EII (also referred to as FruAB) is a fructose-specific permease made up of two proteins (FruA and...; Region: PTS_IIB_fructose; cd05569 481805013288 active site 481805013289 P-loop; other site 481805013290 phosphorylation site [posttranslational modification] 481805013291 Phosphotransferase system, fructose-specific IIC component [Carbohydrate transport and metabolism]; Region: FruA; COG1299 481805013292 putative peptidase; Provisional; Region: PRK09864 481805013293 M42 Peptidase, Endoglucanases; Region: M42_Frv; cd05656 481805013294 oligomer interface [polypeptide binding]; other site 481805013295 active site 481805013296 metal binding site [ion binding]; metal-binding site 481805013297 putative frv operon regulatory protein; Provisional; Region: PRK09863 481805013298 HTH domain; Region: HTH_11; pfam08279 481805013299 PTS_IIA, PTS system, fructose/mannitol specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This...; Region: PTS_IIA_fru; cd00211 481805013300 active site 481805013301 phosphorylation site [posttranslational modification] 481805013302 Protein of unknown function (DUF3829); Region: DUF3829; pfam12889 481805013303 formate dehydrogenase accessory protein; Reviewed; Region: PRK00724 481805013304 formate dehydrogenase, alpha subunit, proteobacterial-type; Region: formate-DH-alph; TIGR01553 481805013305 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 481805013306 [4Fe-4S] binding site [ion binding]; other site 481805013307 Molybdopterin-Binding (MopB) domain of the MopB superfamily of proteins, a large, diverse, heterogeneous superfamily of enzymes that, in general, bind molybdopterin as a cofactor. The MopB domain is found in a wide variety of molybdenum- and...; Region: Molybdopterin-Binding; cl09928 481805013308 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_Formate-Dh-Na-like; cd02752 481805013309 Formate dehydrogenase N, alpha subunit (Formate-Dh-Na) is a major component of nitrate respiration in bacteria such as in the E. coli formate dehydrogenase N (Fdh-N). Fdh-N is a membrane protein that is a complex of three different subunits and is the...; Region: MopB_CT_Formate-Dh-Na-like; cd02792 481805013310 molybdopterin cofactor binding site; other site 481805013311 formate dehydrogenase, beta subunit, Fe-S containing; Region: FDH-beta; TIGR01582 481805013312 Formate dehydrogenase N, transmembrane; Region: Form-deh_trans; pfam09163 481805013313 formate dehydrogenase-O subunit gamma; Provisional; Region: PRK10639 481805013314 formate dehydrogenase, gamma subunit; Region: formate-DH-gamm; TIGR01583 481805013315 formate dehydrogenase accessory protein FdhE; Provisional; Region: PRK03564 481805013316 formate dehydrogenase accessory protein FdhE; Region: FdhE; TIGR01562 481805013317 Ribbon-helix-helix protein, copG family; Region: RHH_1; pfam01402 481805013318 N-Acyltransferase superfamily: Various enzymes that characteristically catalyze the transfer of an acyl group to a substrate; Region: NAT_SF; cd04301 481805013319 Coenzyme A binding pocket [chemical binding]; other site 481805013320 Putative thioesterase (yiiD_Cterm); Region: YiiD_Cterm; pfam09500 481805013321 D-Tyrosyl-tRNAtyr deacylases; a class of tRNA-dependent hydrolases which are capable of hydrolyzing the ester bond of D-Tyrosyl-tRNA reducing the level of cellular D-Tyrosine while recycling the peptidyl-tRNA; found in bacteria and in eukaryotes but not...; Region: Dtyr_deacylase; cd00563 481805013322 putative active site [active] 481805013323 dimerization interface [polypeptide binding]; other site 481805013324 putative tRNAtyr binding site [nucleotide binding]; other site 481805013325 hypothetical protein; Reviewed; Region: PRK01637 481805013326 haloacid dehalogenase superfamily, subfamily IA, variant 3 with third motif having DD or ED; Region: HAD-SF-IA-v3; TIGR01509 481805013327 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805013328 motif II; other site 481805013329 aldose 1-epimerase, similar to Escherichia coli YphB; Region: Aldose_epim_Ec_YphB; cd09021 481805013330 active site 481805013331 catalytic residues [active] 481805013332 shikimate transporter; Provisional; Region: PRK09952 481805013333 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805013334 putative substrate translocation pore; other site 481805013335 benzoate transport; Region: 2A0115; TIGR00895 481805013336 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805013337 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805013338 Medium chain reductase/dehydrogenase (MDR)/zinc-dependent alcohol dehydrogenase-like family; Region: MDR; cl16912 481805013339 putative oxidoreductase; Provisional; Region: PRK10083 481805013340 NAD(P) binding site [chemical binding]; other site 481805013341 Class I aldolases; Region: Aldolase_Class_I; cl17187 481805013342 catalytic residue [active] 481805013343 NADH-dependent gamma-hydroxybutyrate dehydrogenase; Provisional; Region: PRK15461 481805013344 6-phosphogluconate dehydrogenase-like protein; Reviewed; Region: PRK09599 481805013345 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 481805013346 Ribokinase-like subgroup B. Found in bacteria and plants, this subgroup is part of the ribokinase/pfkB superfamily. Its oligomerization state is unknown at this time; Region: ribokinase_group_B; cd01945 481805013347 substrate binding site [chemical binding]; other site 481805013348 ATP binding site [chemical binding]; other site 481805013349 Transcriptional regulators of sugar metabolism [Transcription / Carbohydrate transport and metabolism]; Region: GlpR; COG1349 481805013350 DeoR-like helix-turn-helix domain; Region: HTH_DeoR; pfam08220 481805013351 DeoR C terminal sensor domain; Region: DeoRC; pfam00455 481805013352 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805013353 putative substrate translocation pore; other site 481805013354 phosphoglycerate transporter family protein; Region: 2A0104; TIGR00881 481805013355 Xylose isomerase-like TIM barrel; Region: AP_endonuc_2; pfam01261 481805013356 transcriptional regulator protein; Region: phnR; TIGR03337 481805013357 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805013358 DNA-binding site [nucleotide binding]; DNA binding site 481805013359 UTRA domain; Region: UTRA; pfam07702 481805013360 Predicted membrane GTPase involved in stress response [Signal transduction mechanisms]; Region: TypA; COG1217 481805013361 Tyrosine phosphorylated protein A (TypA)/BipA family belongs to ribosome-binding GTPases; Region: TypA_BipA; cd01891 481805013362 G1 box; other site 481805013363 putative GEF interaction site [polypeptide binding]; other site 481805013364 GTP/Mg2+ binding site [chemical binding]; other site 481805013365 Switch I region; other site 481805013366 G2 box; other site 481805013367 G3 box; other site 481805013368 Switch II region; other site 481805013369 G4 box; other site 481805013370 G5 box; other site 481805013371 BipA_TypA_II: domain II of BipA (also called TypA) having homology to domain II of the elongation factors (EFs) EF-G and EF-Tu. BipA is a highly conserved protein with global regulatory properties in Escherichia coli. BipA is phosphorylated on a...; Region: BipA_TypA_II; cd03691 481805013372 BipA_TypA_C: a C-terminal portion of BipA or TypA having homology to the C terminal domains of the elongation factors EF-G and EF-2. A member of the ribosome binding GTPase superfamily, BipA is widely distributed in bacteria and plants. BipA is a highly...; Region: BipA_TypA_C; cd03710 481805013373 glutamine synthetase; Provisional; Region: glnA; PRK09469 481805013374 Glutamine synthetase, beta-Grasp domain; Region: Gln-synt_N; pfam03951 481805013375 Glutamine synthetase, catalytic domain; Region: Gln-synt_C; pfam00120 481805013376 nitrogen regulation protein NR(II); Provisional; Region: glnL; PRK11073 481805013377 PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in...; Region: PAS; cd00130 481805013378 putative active site [active] 481805013379 heme pocket [chemical binding]; other site 481805013380 Histidine Kinase A (dimerization/phosphoacceptor) domain; Histidine Kinase A dimers are formed through parallel association of 2 domains creating 4-helix bundles; usually these domains contain a conserved His residue and are activated via...; Region: HisKA; cd00082 481805013381 dimer interface [polypeptide binding]; other site 481805013382 phosphorylation site [posttranslational modification] 481805013383 Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyrase B, topoisomerases, heat shock protein HSP90, phytochrome-like ATPases and DNA mismatch repair proteins; Region: HATPase_c; cd00075 481805013384 ATP binding site [chemical binding]; other site 481805013385 Mg2+ binding site [ion binding]; other site 481805013386 G-X-G motif; other site 481805013387 nitrogen regulation protein NR(I); Provisional; Region: glnG; PRK10923 481805013388 Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identified in eukaroytes ETR1 Arabidopsis thaliana; this domain receives the signal from the sensor partner in a two-component systems; Region: REC; cd00156 481805013389 active site 481805013390 phosphorylation site [posttranslational modification] 481805013391 intermolecular recognition site; other site 481805013392 dimerization interface [polypeptide binding]; other site 481805013393 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805013394 Walker A motif; other site 481805013395 ATP binding site [chemical binding]; other site 481805013396 Walker B motif; other site 481805013397 arginine finger; other site 481805013398 Bacterial regulatory protein, Fis family; Region: HTH_8; pfam02954 481805013399 coproporphyrinogen III oxidase; Provisional; Region: PRK09249 481805013400 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805013401 FeS/SAM binding site; other site 481805013402 HemN C-terminal domain; Region: HemN_C; pfam06969 481805013403 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3078 481805013404 YihA (EngB) GTPase family; Region: YihA_EngB; cd01876 481805013405 G1 box; other site 481805013406 GTP/Mg2+ binding site [chemical binding]; other site 481805013407 Switch I region; other site 481805013408 G2 box; other site 481805013409 G3 box; other site 481805013410 Switch II region; other site 481805013411 G4 box; other site 481805013412 G5 box; other site 481805013413 DNA polymerase I; Provisional; Region: PRK05755 481805013414 PIN domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: PIN_53EXO; cd09859 481805013415 active site 481805013416 metal binding site 1 [ion binding]; metal-binding site 481805013417 putative 5' ssDNA interaction site; other site 481805013418 metal binding site 3; metal-binding site 481805013419 metal binding site 2 [ion binding]; metal-binding site 481805013420 H3TH domain of the 5'-3' exonuclease of Taq DNA polymerase I and homologs; Region: H3TH_53EXO; cd09898 481805013421 putative DNA binding site [nucleotide binding]; other site 481805013422 putative metal binding site [ion binding]; other site 481805013423 DEDDy 3'-5' exonuclease domain of Escherichia coli DNA polymerase I and similar bacterial family-A DNA polymerases; Region: DNA_polA_I_Ecoli_like_exo; cd06139 481805013424 active site 481805013425 catalytic site [active] 481805013426 substrate binding site [chemical binding]; other site 481805013427 Polymerase I functions primarily to fill DNA gaps that arise during DNA repair, recombination and replication; Region: DNA_pol_A_pol_I_C; cd08637 481805013428 active site 481805013429 DNA binding site [nucleotide binding] 481805013430 catalytic site [active] 481805013431 1-acyl-sn-glycerol-3-phosphate acyltransferase [Lipid metabolism]; Region: PlsC; COG0204 481805013432 Lysophospholipid Acyltransferases (LPLATs) of Glycerophospholipid Biosynthesis: LCLAT1-like; Region: LPLAT_LCLAT1-like; cd07990 481805013433 putative acyl-acceptor binding pocket; other site 481805013434 hypothetical protein; Provisional; Region: PRK11367 481805013435 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG5339 481805013436 DsbA family, DsbA subfamily; DsbA is a monomeric thiol disulfide oxidoreductase protein containing a redox active CXXC motif imbedded in a TRX fold. It is involved in the oxidative protein folding pathway in prokaryotes, and is the strongest thiol...; Region: DsbA_DsbA; cd03019 481805013437 DSBA-like thioredoxin domain; Region: DSBA; pfam01323 481805013438 catalytic residues [active] 481805013439 hinge region; other site 481805013440 alpha helical domain; other site 481805013441 Putative homoserine kinase type II (protein kinase fold) [General function prediction only]; Region: COG2334 481805013442 serine/threonine protein kinase; Provisional; Region: PRK11768 481805013443 Protein of unknown function (DUF1040); Region: DUF1040; pfam06288 481805013444 molybdopterin-guanine dinucleotide biosynthesis protein MobA; Reviewed; Region: mobA; PRK00317 481805013445 MobA catalyzes the formation of molybdopterin guanine dinucleotide; Region: MobA; cd02503 481805013446 GTP binding site; other site 481805013447 Molybdenum is an essential trace element in the form of molybdenum cofactor (Moco) which is associated with the metabolism of nitrogen, carbon and sulfur by redox active enzymes. In E. coli, the synthesis of Moco involves genes from several loci: moa; Region: MobB; cd03116 481805013448 Walker A motif; other site 481805013449 protoporphyrinogen oxidase; Provisional; Region: hemG; PRK11104 481805013450 potassium transporter; Provisional; Region: PRK10750 481805013451 potassium uptake protein, TrkH family; Region: 2a38; TIGR00933 481805013452 hypothetical protein; Provisional; Region: PRK11568 481805013453 Uncharacterized protein family UPF0029; Region: UPF0029; pfam01205 481805013454 Domain of unknown function (DUF1949); Region: DUF1949; pfam09186 481805013455 proline dipeptidase; Provisional; Region: PRK13607 481805013456 Prolidase. E.C. 3.4.13.9. Also known as Xaa-Pro dipeptidase, X-Pro dipeptidase, proline dipeptidase., imidodipeptidase, peptidase D, gamma-peptidase. Catalyses hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on...; Region: Prolidase; cd01087 481805013457 active site 481805013458 multifunctional fatty acid oxidation complex subunit alpha; Reviewed; Region: fadB; PRK11730 481805013459 Crotonase/Enoyl-Coenzyme A (CoA) hydratase superfamily. This superfamily contains a diverse set of enzymes including enoyl-CoA hydratase, napthoate synthase, methylmalonyl-CoA decarboxylase, 3-hydoxybutyryl-CoA dehydratase, and dienoyl-CoA isomerase; Region: crotonase-like; cd06558 481805013460 substrate binding site [chemical binding]; other site 481805013461 oxyanion hole (OAH) forming residues; other site 481805013462 trimer interface [polypeptide binding]; other site 481805013463 3-hydroxyacyl-CoA dehydrogenase, NAD binding domain; Region: 3HCDH_N; pfam02737 481805013464 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 481805013465 3-hydroxyacyl-CoA dehydrogenase, C-terminal domain; Region: 3HCDH; pfam00725 481805013466 3-ketoacyl-CoA thiolase; Reviewed; Region: fadA; PRK08947 481805013467 Thiolase are ubiquitous enzymes that catalyze the reversible thiolytic cleavage of 3-ketoacyl-CoA into acyl-CoA and acetyl-CoA, a 2-step reaction involving a covalent intermediate formed with a catalytic cysteine. They are found in prokaryotes and...; Region: thiolase; cd00751 481805013468 dimer interface [polypeptide binding]; other site 481805013469 active site 481805013470 FMN reductase; Validated; Region: fre; PRK08051 481805013471 NAD(P)H dependent flavin oxidoreductases use flavin as a substrate in mediating electron transfer from iron complexes or iron proteins. Structurally similar to ferredoxin reductases, but with only 15% sequence identity, flavin reductases reduce FAD, FMN; Region: flavin_oxioreductase; cd06189 481805013472 FAD binding pocket [chemical binding]; other site 481805013473 FAD binding motif [chemical binding]; other site 481805013474 phosphate binding motif [ion binding]; other site 481805013475 beta-alpha-beta structure motif; other site 481805013476 NAD binding pocket [chemical binding]; other site 481805013477 3-octaprenyl-4-hydroxybenzoate decarboxylase; Provisional; Region: PRK10922 481805013478 transcriptional activator RfaH; Provisional; Region: rfaH; PRK09014 481805013479 N-Utilization Substance G (NusG) N-terminal domain in the NusG Specialized Paralog (SP), RfaH; Region: NGN_SP_RfaH; cd09892 481805013480 KOW: an acronym for the authors' surnames (Kyrpides, Ouzounis and Woese); Region: KOW; cl00354 481805013481 TatD like proteins; E.coli TatD is a cytoplasmic protein, shown to have magnesium dependent DNase activity; Region: TatD_DNAse; cd01310 481805013482 active site 481805013483 twin-arginine protein translocation system subunit TatC; Provisional; Region: PRK10921 481805013484 sec-independent translocase; Provisional; Region: PRK01770 481805013485 sec-independent translocase; Provisional; Region: tatB; PRK00404 481805013486 twin arginine translocase protein A; Provisional; Region: tatA; PRK03554 481805013487 twin arginine translocase protein A; Provisional; Region: tatA; PRK00575 481805013488 putative ubiquinone biosynthesis protein UbiB; Reviewed; Region: ubiB; PRK04750 481805013489 2-polyprenylphenol 6-hydroxylase; Region: UbiB; TIGR01982 481805013490 Uncharacterized protein conserved in bacteria [Function unknown]; Region: COG3165 481805013491 SCP-2 sterol transfer family; Region: SCP2; pfam02036 481805013492 ubiE/COQ5 methyltransferase family; Region: Ubie_methyltran; pfam01209 481805013493 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805013494 S-adenosylmethionine binding site [chemical binding]; other site 481805013495 DNA recombination protein RmuC; Provisional; Region: PRK10361 481805013496 RmuC family; Region: RmuC; pfam02646 481805013497 uridine phosphorylase; Provisional; Region: PRK11178 481805013498 uridine phosphorylase; Region: Uridine-psphlse; TIGR01718 481805013499 Dienelactone hydrolase and related enzymes [Secondary metabolites biosynthesis, transport, and catabolism]; Region: COG0412 481805013500 BAAT / Acyl-CoA thioester hydrolase C terminal; Region: BAAT_C; pfam08840 481805013501 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase; Provisional; Region: PRK05222 481805013502 CIMS - Cobalamine-independent methonine synthase, or MetE, N-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_N_terminal_like; cd03312 481805013503 THF binding site; other site 481805013504 CIMS - Cobalamine-independent methonine synthase, or MetE, C-terminal domain_like. Many members have been characterized as 5-methyltetrahydropteroyltriglutamate-homocysteine methyltransferases, EC:2.1.1.14, mostly from bacteria and plants. This enzyme...; Region: CIMS_C_terminal_like; cd03311 481805013505 substrate binding site [chemical binding]; other site 481805013506 THF binding site; other site 481805013507 zinc-binding site [ion binding]; other site 481805013508 DNA-binding transcriptional regulator MetR; Provisional; Region: PRK15421 481805013509 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805013510 The C-terminal substrate binding domain of LysR-type transcriptional regulator metR, which regulates the expression of methionine biosynthetic genes, contains type 2 periplasmic binding fold; Region: PBP2_MetR; cd08441 481805013511 putative dimerization interface [polypeptide binding]; other site 481805013512 Carboxylate/Amino Acid/Amine Transporter; Region: 2A78; TIGR00950 481805013513 EamA-like transporter family; Region: EamA; pfam00892 481805013514 putative hydrolase; Provisional; Region: PRK10976 481805013515 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805013516 active site 481805013517 motif I; other site 481805013518 motif II; other site 481805013519 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805013520 lysophospholipase L2; Provisional; Region: PRK10749 481805013521 Putative lysophospholipase; Region: Hydrolase_4; pfam12146 481805013522 homoserine/homoserine lactone efflux protein; Provisional; Region: rhtB; PRK10520 481805013523 threonine efflux system; Provisional; Region: PRK10229 481805013524 ATP-dependent DNA helicase RecQ; Provisional; Region: PRK11057 481805013525 DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region; Region: DEXDc; cd00046 481805013526 ATP binding site [chemical binding]; other site 481805013527 putative Mg++ binding site [ion binding]; other site 481805013528 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805013529 nucleotide binding region [chemical binding]; other site 481805013530 ATP-binding site [chemical binding]; other site 481805013531 This DNA-binding domain is found in the RecQ helicase among others and has a helix-turn-helix structure; Region: RQC; smart00956 481805013532 Helicase and RNase D C-terminal; Region: HRDC; smart00341 481805013533 The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among...; Region: OMPLA; cd00541 481805013534 dimerization interface [polypeptide binding]; other site 481805013535 substrate binding site [chemical binding]; other site 481805013536 active site 481805013537 calcium binding site [ion binding]; other site 481805013538 PaaI_thioesterase is a tetrameric acyl-CoA thioesterase with a hot dog fold and one of several proteins responsible for phenylacetic acid (PA) degradation in bacteria. Although orthologs of PaaI exist in archaea and eukaryotes, their function has not...; Region: PaaI_thioesterase; cd03443 481805013539 CoenzymeA binding site [chemical binding]; other site 481805013540 subunit interaction site [polypeptide binding]; other site 481805013541 PHB binding site; other site 481805013542 putative chloramphenical resistance permease RarD; Provisional; Region: PRK15430 481805013543 EamA-like transporter family; Region: EamA; cl17759 481805013544 hypothetical protein; Provisional; Region: PRK11371 481805013545 Protein of unknown function (DUF2628); Region: DUF2628; pfam10947 481805013546 Mg2+ and Co2+ transporters [Inorganic ion transport and metabolism]; Region: CorA; COG0598 481805013547 Escherichia coli Mg2+ transporter CorA_like subgroup; Region: EcCorA-like_1; cd12835 481805013548 Cl binding site [ion binding]; other site 481805013549 oligomer interface [polypeptide binding]; other site 481805013550 Predicted periplasmic protein [Function unknown]; Region: COG3698 481805013551 Predicted periplasmic protein (DUF2233); Region: DUF2233; pfam09992 481805013552 DNA-dependent helicase II; Provisional; Region: uvrD; PRK11773 481805013553 Part of AAA domain; Region: AAA_19; pfam13245 481805013554 Family description; Region: UvrD_C_2; pfam13538 481805013555 flavin mononucleotide phosphatase; Provisional; Region: PRK10748 481805013556 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805013557 motif II; other site 481805013558 Site-specific recombinase XerC [DNA replication, recombination, and repair]; Region: XerC; COG4973 481805013559 DNA breaking-rejoining enzymes, C-terminal catalytic domain. The DNA breaking-rejoining enzyme superfamily includes type IB topoisomerases and tyrosine recombinases that share the same fold in their catalytic domain containing six conserved active site...; Region: DNA_BRE_C; cl00213 481805013560 active site 481805013561 DNA binding site [nucleotide binding] 481805013562 Int/Topo IB signature motif; other site 481805013563 hypothetical protein; Provisional; Region: PRK10963 481805013564 diaminopimelate epimerase; Provisional; Region: dapF; PRK00450 481805013565 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 481805013566 Diaminopimelate epimerase; Region: DAP_epimerase; pfam01678 481805013567 Predicted small periplasmic lipoprotein [Cell motility and secretion]; Region: COG5567 481805013568 Frataxin is a nuclear-encoded mitochondrial protein implicated in Friedreich's ataxia (FRDA), an human autosomal recessive neurodegenerative disease; Frataxin is found in eukaryotes and in purple bacteria; lack of frataxin causes iron to accumulate...; Region: Frataxin; cd00503 481805013569 putative iron binding site [ion binding]; other site 481805013570 Adenylate cyclase [Nucleotide transport and metabolism]; Region: CyaA; COG3072 481805013571 Adenylate cyclase NT domain; Region: Adenyl_cycl_N; pfam12633 481805013572 Adenylate cyclase, class-I; Region: Adenylate_cycl; pfam01295 481805013573 porphobilinogen deaminase; Reviewed; Region: hemC; PRK00072 481805013574 Hydroxymethylbilane synthase (HMBS), also known as porphobilinogen deaminase (PBGD), is an intermediate enzyme in the biosynthetic pathway of tetrapyrrolic ring systems, such as heme, chlorophylls, and vitamin B12. HMBS catalyzes the conversion of...; Region: HMBS; cd00494 481805013575 domain interfaces; other site 481805013576 active site 481805013577 uroporphyrinogen-III synthase; Reviewed; Region: hemD; PRK05928 481805013578 Uroporphyrinogen-III synthase (HemD) catalyzes the asymmetrical cyclization of tetrapyrrole (linear) to uroporphyrinogen-III, the fourth step in the biosynthesis of heme. This ubiquitous enzyme is present in eukaryotes, bacteria and archaea. Mutations in...; Region: HemD; cd06578 481805013579 active site 481805013580 Uncharacterized enzyme of heme biosynthesis [Coenzyme metabolism]; Region: HemX; COG2959 481805013581 putative uroporphyrinogen III C-methyltransferase; Provisional; Region: PRK10920 481805013582 putative protoheme IX biogenesis protein; Provisional; Region: PRK10747 481805013583 HemY protein N-terminus; Region: HemY_N; pfam07219 481805013584 anaerobic sulfatase-maturating enzyme; Region: sulfatase_rSAM; TIGR03942 481805013585 Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine (SAM) in close proximity. They are characterized by a conserved CxxxCxxC motif, which coordinates the conserved iron-sulfur cluster; Region: Radical_SAM; cd01335 481805013586 FeS/SAM binding site; other site 481805013587 radical SAM additional 4Fe4S-binding SPASM domain; Region: rSAM_more_4Fe4S; TIGR04085 481805013588 putative transport protein YifK; Provisional; Region: PRK10746 481805013589 Teichoic acid biosynthesis proteins [Cell envelope biogenesis, outer membrane]; Region: WecG; COG1922 481805013590 The glycosyltransferase WecG/TagA superfamily contains Escherichia coli WecG, Bacillus subtilis TagA and related proteins. E. coli WecG is believed to be a UDP-N-acetyl-D-mannosaminuronic acid transferase, and is involved in enterobacterial common...; Region: Glyco_transf_WecG_TagA; cd06533 481805013591 putative common antigen polymerase; Provisional; Region: PRK02975 481805013592 4-alpha-L-fucosyltransferase glycosyl transferase group 56; Region: Glyco_transf_56; pfam07429 481805013593 Membrane protein involved in the export of O-antigen and teichoic acid [General function prediction only]; Region: RfbX; COG2244 481805013594 Uncharacterized subfamily of the multidrug and toxic compound extrusion (MATE) proteins; Region: MATE_like_10; cd13125 481805013595 Predicted pyridoxal phosphate-dependent enzyme apparently involved in regulation of cell wall biogenesis [Cell envelope biogenesis, outer membrane]; Region: WecE; COG0399 481805013596 3-amino-5-hydroxybenzoic acid synthase family (AHBA_syn). AHBA_syn family belongs to pyridoxal phosphate (PLP)-dependent aspartate aminotransferase superfamily (fold I). The members of this CD are involved in various biosynthetic pathways for secondary...; Region: AHBA_syn; cd00616 481805013597 inhibitor-cofactor binding pocket; inhibition site 481805013598 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805013599 catalytic residue [active] 481805013600 TDP-fucosamine acetyltransferase; Provisional; Region: PRK10975 481805013601 G1P_TT_short is the short form of glucose-1-phosphate thymidylyltransferase; Region: G1P_TT_short; cd02538 481805013602 glucose-1-phosphate thymidylyltransferase, short form; Region: rmlA; TIGR01207 481805013603 substrate binding site; other site 481805013604 tetramer interface; other site 481805013605 dTDP-glucose 4,6-dehydratase; Provisional; Region: PRK10217 481805013606 dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs; Region: dTDP_GD_SDR_e; cd05246 481805013607 NAD binding site [chemical binding]; other site 481805013608 substrate binding site [chemical binding]; other site 481805013609 homodimer interface [polypeptide binding]; other site 481805013610 active site 481805013611 UDP-N-acetyl-D-mannosamine dehydrogenase; Provisional; Region: wecC; PRK11064 481805013612 Ketopantoate reductase PanE/ApbA; Region: ApbA; pfam02558 481805013613 UDP-glucose/GDP-mannose dehydrogenase family, central domain; Region: UDPG_MGDP_dh; pfam00984 481805013614 UDP binding domain; Region: UDPG_MGDP_dh_C; smart00984 481805013615 UDP-N-acetylglucosamine 2-epimerase; Region: wecB; TIGR00236 481805013616 Bacterial members of the UDP-N-Acetylglucosamine (GlcNAc) 2-Epimerase family are known to catalyze the reversible interconversion of UDP-GlcNAc and UDP-N-acetylmannosamine (UDP-ManNAc). The enzyme serves to produce an activated form of ManNAc residues; Region: GT1_UDP-GlcNAc_2-Epimerase; cd03786 481805013617 active site 481805013618 homodimer interface [polypeptide binding]; other site 481805013619 lipopolysaccharide biosynthesis protein WzzE; Provisional; Region: PRK11638 481805013620 Chain length determinant protein; Region: Wzz; pfam02706 481805013621 undecaprenyl-phosphate alpha-N-acetylglucosaminyl 1-phosphate transferase; Provisional; Region: PRK15119 481805013622 This subfamily contains Escherichia coli WecA, Bacillus subtilis TagO and related proteins. WecA is an UDP-N-acetylglucosamine (GlcNAc):undecaprenyl-phosphate (Und-P) GlcNAc-1-phosphate transferase that catalyzes the formation of a phosphodiester bond...; Region: GT_WecA_like; cd06853 481805013623 Mg++ binding site [ion binding]; other site 481805013624 putative catalytic motif [active] 481805013625 substrate binding site [chemical binding]; other site 481805013626 transcription termination factor Rho; Provisional; Region: rho; PRK09376 481805013627 Rho termination factor, N-terminal domain; Region: Rho_N; smart00959 481805013628 Rho_CSD: Rho protein cold-shock domain (CSD). Rho protein is a transcription termination factor in most bacteria. In bacteria, there are two distinct mechanisms for mRNA transcription termination. In intrinsic termination, RNA polymerase and nascent mRNA...; Region: Rho_CSD; cd04459 481805013629 RNA binding site [nucleotide binding]; other site 481805013630 Transcription termination factor rho is a bacterial ATP-dependent RNA/DNA helicase. It is a homohexamer. Each monomer consists of an N-terminal domain of the OB fold, which is responsible for binding to cysteine rich nucleotides. This alignment is of the...; Region: rho_factor; cd01128 481805013631 multimer interface [polypeptide binding]; other site 481805013632 Walker A motif; other site 481805013633 ATP binding site [chemical binding]; other site 481805013634 Walker B motif; other site 481805013635 putative rho operon leader peptide; Provisional; Region: PRK09979 481805013636 TRX family; composed of two groups: Group I, which includes proteins that exclusively encode a TRX domain; and Group II, which are composed of fusion proteins of TRX and additional domains. Group I TRX is a small ancient protein that alter the redox...; Region: TRX_family; cd02947 481805013637 Thioredoxin-like; Region: Thioredoxin_8; pfam13905 481805013638 catalytic residues [active] 481805013639 ATP-dependent RNA helicase RhlB; Provisional; Region: PRK04837 481805013640 DEAD-box helicases. A diverse family of proteins involved in ATP-dependent RNA unwinding, needed in a variety of cellular processes including splicing, ribosome biogenesis and RNA degradation. The name derives from the sequence of the Walker B motif; Region: DEADc; cd00268 481805013641 ATP binding site [chemical binding]; other site 481805013642 Mg++ binding site [ion binding]; other site 481805013643 motif III; other site 481805013644 Helicase superfamily c-terminal domain; associated with DEXDc-, DEAD-, and DEAH-box proteins, yeast initiation factor 4A, Ski2p, and Hepatitis C virus NS3 helicases; this domain is found in a wide variety of helicases and helicase related proteins; may...; Region: HELICc; cd00079 481805013645 nucleotide binding region [chemical binding]; other site 481805013646 ATP-binding site [chemical binding]; other site 481805013647 guanosine pentaphosphate phosphohydrolase; Provisional; Region: PRK11031 481805013648 Ppx/GppA phosphatase family; Region: Ppx-GppA; pfam02541 481805013649 ATP-dependent DNA helicase Rep; Provisional; Region: PRK10919 481805013650 Part of AAA domain; Region: AAA_19; pfam13245 481805013651 Family description; Region: UvrD_C_2; pfam13538 481805013652 peptidyl-prolyl cis-trans isomerase C; Provisional; Region: PRK15441 481805013653 Parvulin-like peptidyl-prolyl isomerase [Posttranslational modification, protein turnover, chaperones]; Region: SurA; COG0760 481805013654 ketol-acid reductoisomerase; Validated; Region: PRK05225 481805013655 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvN; pfam07991 481805013656 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 481805013657 Acetohydroxy acid isomeroreductase, catalytic domain; Region: IlvC; pfam01450 481805013658 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805013659 DNA-binding transcriptional regulator IlvY; Provisional; Region: PRK11716 481805013660 The C-terminal substrate binding of LysR-type transcriptional regulator IlvY, which activates the expression of ilvC gene that encoding acetohydroxy acid isomeroreductase for the biosynthesis of branched amino acids; contains the type 2 periplasmic bindin; Region: PBP2_IlvY; cd08430 481805013661 putative dimerization interface [polypeptide binding]; other site 481805013662 threonine dehydratase; Reviewed; Region: PRK09224 481805013663 Threonine dehydratase: The first step in amino acid degradation is the removal of nitrogen. Although the nitrogen atoms of most amino acids are transferred to alpha-ketoglutarate before removal, the alpha-amino group of threonine can be directly...; Region: Thr-dehyd; cd01562 481805013664 tetramer interface [polypeptide binding]; other site 481805013665 pyridoxal 5'-phosphate binding site [chemical binding]; other site 481805013666 catalytic residue [active] 481805013667 First of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_1; cd04906 481805013668 putative Ile/Val binding site [chemical binding]; other site 481805013669 Second of two tandem C-terminal ACT domains of threonine dehydratase I (ThrD-I; L-threonine hydrolyase); Region: ACT_ThrD-I_2; cd04907 481805013670 putative Ile/Val binding site [chemical binding]; other site 481805013671 dihydroxy-acid dehydratase; Provisional; Region: PRK12448 481805013672 Branched-chain amino acid aminotransferase/4-amino-4-deoxychorismate lyase [Amino acid transport and metabolism / Coenzyme metabolism]; Region: IlvE; COG0115 481805013673 BCAT_beta_family: Branched-chain aminotransferase catalyses the transamination of the branched-chain amino acids leusine, isoleucine and valine to their respective alpha-keto acids, alpha-ketoisocaproate, alpha-keto-beta-methylvalerate and...; Region: BCAT_beta_family; cd01557 481805013674 homodimer interface [polypeptide binding]; other site 481805013675 substrate-cofactor binding pocket; other site 481805013676 catalytic residue [active] 481805013677 acetolactate synthase 2 regulatory subunit; Provisional; Region: ilvM; PRK11152 481805013678 acetolactate synthase 2 catalytic subunit; Reviewed; Region: PRK08978 481805013679 Pyrimidine (PYR) binding domain of POX and related proteins; Region: TPP_PYR_POX_like; cd07035 481805013680 PYR/PP interface [polypeptide binding]; other site 481805013681 dimer interface [polypeptide binding]; other site 481805013682 TPP binding site [chemical binding]; other site 481805013683 Thiamine pyrophosphate enzyme, central domain; Region: TPP_enzyme_M; pfam00205 481805013684 Thiamine pyrophosphate (TPP) family, Acetohydroxyacid synthase (AHAS) subfamily, TPP-binding module; composed of proteins similar to the large catalytic subunit of AHAS. AHAS catalyzes the condensation of two molecules of pyruvate to give the...; Region: TPP_AHAS; cd02015 481805013685 TPP-binding site [chemical binding]; other site 481805013686 dimer interface [polypeptide binding]; other site 481805013687 ilvG operon leader peptide; Provisional; Region: PRK10424 481805013688 putative ATP-dependent protease; Provisional; Region: PRK09862 481805013689 Subunit ChlI of Mg-chelatase; Region: ChlI; pfam13541 481805013690 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805013691 Walker A motif; other site 481805013692 ATP binding site [chemical binding]; other site 481805013693 Walker B motif; other site 481805013694 arginine finger; other site 481805013695 Magnesium chelatase, subunit ChlI; Region: Mg_chelatase_2; pfam13335 481805013696 hypothetical protein; Provisional; Region: PRK11027 481805013697 transcriptional regulator HdfR; Provisional; Region: PRK03601 481805013698 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805013699 LysR substrate binding domain; Region: LysR_substrate; pfam03466 481805013700 dimerization interface [polypeptide binding]; other site 481805013701 Transcriptional regulators [Transcription]; Region: FadR; COG2186 481805013702 Winged helix-turn-helix (WHTH) DNA-binding domain of the GntR family of transcriptional regulators; Region: WHTH_GntR; cd07377 481805013703 DNA-binding site [nucleotide binding]; DNA binding site 481805013704 This entry represents the C-terminal ligand binding domain of many members of the GntR family; Region: FCD; smart00895 481805013705 putative transporter; Provisional; Region: PRK10504 481805013706 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805013707 putative substrate translocation pore; other site 481805013708 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805013709 transcriptional repressor RbsR; Provisional; Region: PRK10423 481805013710 Helix-turn-helix (HTH) DNA binding domain of the LacI family of transcriptional regulators; Region: HTH_LacI; cd01392 481805013711 DNA binding site [nucleotide binding] 481805013712 domain linker motif; other site 481805013713 Ligand-binding domain of purine repressor, PurR, which functions as the master regulatory protein of de novo purine nucleotide biosynthesis in Escherichia coli; Region: PBP1_PurR; cd06275 481805013714 dimerization interface [polypeptide binding]; other site 481805013715 ligand binding site [chemical binding]; other site 481805013716 Ribokinase catalyses the phosphorylation of ribose to ribose-5-phosphate using ATP. This reaction is the first step in the ribose metabolism. It traps ribose within the cell after uptake and also prepares the sugar for use in the synthesis of nucleotides...; Region: ribokinase; cd01174 481805013717 Sugar kinases, ribokinase family [Carbohydrate transport and metabolism]; Region: RbsK; COG0524 481805013718 substrate binding site [chemical binding]; other site 481805013719 dimer interface [polypeptide binding]; other site 481805013720 ATP binding site [chemical binding]; other site 481805013721 D-ribose transporter subunit RbsB; Provisional; Region: PRK10653 481805013722 Periplasmic sugar-binding domain of the thermophilic Thermoanaerobacter tengcongensis ribose binding protein (ttRBP) and its mesophilic homologs; Region: PBP1_ribose_binding; cd06323 481805013723 ligand binding site [chemical binding]; other site 481805013724 dimerization interface [polypeptide binding]; other site 481805013725 Branched-chain amino acid transport system / permease component; Region: BPD_transp_2; pfam02653 481805013726 Transmembrane subunit (TM) of Escherichia coli AraH and related proteins. E. coli AraH is the TM of a Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporter involved in the uptake of the monosaccharide arabinose. This group...; Region: TM_PBP1_transp_AraH_like; cd06579 481805013727 TM-ABC transporter signature motif; other site 481805013728 D-ribose transporter ATP binding protein; Provisional; Region: PRK10762 481805013729 First domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_I; cd03216 481805013730 Walker A/P-loop; other site 481805013731 ATP binding site [chemical binding]; other site 481805013732 Q-loop/lid; other site 481805013733 ABC transporter signature motif; other site 481805013734 Walker B; other site 481805013735 D-loop; other site 481805013736 H-loop/switch region; other site 481805013737 Second domain of the ATP-binding cassette component of monosaccharide transport system; Region: ABC_Carb_Monos_II; cd03215 481805013738 D-ribose pyranase; Provisional; Region: PRK11797 481805013739 potassium transport protein Kup; Provisional; Region: trkD; PRK10745 481805013740 potassium uptake protein; Region: kup; TIGR00794 481805013741 regulatory ATPase RavA; Provisional; Region: PRK13531 481805013742 The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC; Region: AAA; cd00009 481805013743 Walker A motif; other site 481805013744 ATP binding site [chemical binding]; other site 481805013745 Walker B motif; other site 481805013746 arginine finger; other site 481805013747 Protein of unknown function (DUF3763); Region: DUF3763; pfam12592 481805013748 hypothetical protein; Provisional; Region: yieM; PRK10997 481805013749 VWA YIEM type: Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b...; Region: VWA_YIEM_type; cd01462 481805013750 metal ion-dependent adhesion site (MIDAS); other site 481805013751 Asparagine synthetase (aspartate-ammonia ligase) (AsnA) catalyses the conversion of L-aspartate to L-asparagine in the presence of ATP and ammonia. AsnA is a homodimeric enzyme which is structurally similiar to the catalytic core domain of class II...; Region: AsnA; cd00645 481805013752 dimer interface [polypeptide binding]; other site 481805013753 active site 481805013754 DNA-binding transcriptional regulator AsnC; Provisional; Region: PRK11179 481805013755 Arsenical Resistance Operon Repressor and similar prokaryotic, metal regulated homodimeric repressors. ARSR subfamily of helix-turn-helix bacterial transcription regulatory proteins (winged helix topology). Includes several proteins that appear to...; Region: HTH_ARSR; cd00090 481805013756 putative DNA binding site [nucleotide binding]; other site 481805013757 putative Zn2+ binding site [ion binding]; other site 481805013758 AsnC family; Region: AsnC_trans_reg; pfam01037 481805013759 FMN-binding protein MioC; Provisional; Region: PRK09004 481805013760 tRNA uridine 5-carboxymethylaminomethyl modification enzyme GidA; Validated; Region: PRK05192 481805013761 NAD(FAD)-utilizing enzyme possibly involved in translation [Translation, ribosomal structure and biogenesis]; Region: Gid; COG1206 481805013762 GidA associated domain 3; Region: GIDA_assoc_3; pfam13932 481805013763 Predicted S-adenosylmethionine-dependent methyltransferase involved in bacterial cell division [Cell envelope biogenesis, outer membrane]; Region: GidB; COG0357 481805013764 S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy); Region: AdoMet_MTases; cd02440 481805013765 S-adenosylmethionine binding site [chemical binding]; other site 481805013766 F0F1 ATP synthase subunit I; Validated; Region: PRK08049 481805013767 F0F1-type ATP synthase, subunit a [Energy production and conversion]; Region: AtpB; COG0356 481805013768 F0F1 ATP synthase subunit A; Validated; Region: PRK05815 481805013769 F0F1 ATP synthase subunit C; Validated; Region: PRK06876 481805013770 F0F1 ATP synthase subunit B; Validated; Region: PRK05759 481805013771 F0F1-type ATP synthase, subunit b [Energy production and conversion]; Region: AtpF; COG0711 481805013772 F0F1 ATP synthase subunit delta; Validated; Region: PRK05758 481805013773 ATP synthase delta (OSCP) subunit; Region: OSCP; pfam00213 481805013774 F0F1 ATP synthase subunit alpha; Validated; Region: PRK09281 481805013775 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 481805013776 F1 ATP synthase alpha, central domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a proton gradient to...; Region: F1_ATPase_alpha; cd01132 481805013777 beta subunit interaction interface [polypeptide binding]; other site 481805013778 Walker A motif; other site 481805013779 ATP binding site [chemical binding]; other site 481805013780 Walker B motif; other site 481805013781 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 481805013782 mitochondrial ATP synthase gamma subunit; Region: F1-ATPase_gamma; cd12151 481805013783 core domain interface [polypeptide binding]; other site 481805013784 delta subunit interface [polypeptide binding]; other site 481805013785 epsilon subunit interface [polypeptide binding]; other site 481805013786 F0F1 ATP synthase subunit beta; Validated; Region: PRK09280 481805013787 ATP synthase alpha/beta family, beta-barrel domain; Region: ATP-synt_ab_N; pfam02874 481805013788 F1 ATP synthase beta subunit, nucleotide-binding domain. The F-ATPase is found in bacterial plasma membranes, mitochondrial inner membranes and in chloroplast thylakoid membranes. It has also been found in the archaea Methanosarcina barkeri. It uses a...; Region: F1-ATPase_beta; cd01133 481805013789 alpha subunit interaction interface [polypeptide binding]; other site 481805013790 Walker A motif; other site 481805013791 ATP binding site [chemical binding]; other site 481805013792 Walker B motif; other site 481805013793 inhibitor binding site; inhibition site 481805013794 ATP synthase alpha/beta chain, C terminal domain; Region: ATP-synt_ab_C; pfam00306 481805013795 F0F1 ATP synthase subunit epsilon; Validated; Region: atpC; PRK00571 481805013796 mitochondrial ATP synthase delta subunit; Region: F1-ATPase_delta; cd12152 481805013797 gamma subunit interface [polypeptide binding]; other site 481805013798 epsilon subunit interface [polypeptide binding]; other site 481805013799 LBP interface [polypeptide binding]; other site 481805013800 bifunctional N-acetylglucosamine-1-phosphate uridyltransferase/glucosamine-1-phosphate acetyltransferase; Provisional; Region: glmU; PRK09451 481805013801 N-terminal domain of bacterial GlmU; Region: GT2_GlmU_N_bac; cd02540 481805013802 Substrate binding site; other site 481805013803 Mg++ binding site; other site 481805013804 N-acetyl-glucosamine-1-phosphate uridyltransferase (GlmU), C-terminal left-handed beta-helix (LbH) acetyltransferase domain: GlmU is also known as UDP-N-acetylglucosamine pyrophosphorylase. It is a bifunctional bacterial enzyme that catalyzes two...; Region: LbH_GlmU_C; cd03353 481805013805 active site 481805013806 substrate binding site [chemical binding]; other site 481805013807 CoA binding site [chemical binding]; other site 481805013808 glucosamine--fructose-6-phosphate aminotransferase; Reviewed; Region: PRK00331 481805013809 Glutamine amidotransferases class-II (Gn-AT)_GFAT-type. This domain is found at the N-terminus of glucosamine-6P synthase (GlmS, or GFAT in humans). The glutaminase domain catalyzes amide nitrogen transfer from glutamine to the appropriate substrate. In...; Region: GFAT; cd00714 481805013810 glutaminase active site [active] 481805013811 SIS (Sugar ISomerase) domain repeat 1 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_1; cd05008 481805013812 dimer interface [polypeptide binding]; other site 481805013813 active site 481805013814 SIS (Sugar ISomerase) domain repeat 2 found in Glucosamine 6-phosphate synthase (GlmS) and Glucosamine-6-phosphate deaminase (GlmD). The SIS domain is found in many phosphosugar isomerases and phosphosugar binding proteins. GlmS contains a N-terminal...; Region: SIS_GlmS_GlmD_2; cd05009 481805013815 dimer interface [polypeptide binding]; other site 481805013816 active site 481805013817 Bacterial periplasmic transport systems use membrane-bound complexes and substrate-bound, membrane-associated, periplasmic binding proteins (PBPs) to transport a wide variety of substrates, such as, amino acids, peptides, sugars, vitamins and inorganic...; Region: PBPb; cd00134 481805013818 phosphate transporter permease subunit PstC; Provisional; Region: pstC; PRK11275 481805013819 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805013820 dimer interface [polypeptide binding]; other site 481805013821 conserved gate region; other site 481805013822 putative PBP binding loops; other site 481805013823 ABC-ATPase subunit interface; other site 481805013824 phosphate transporter permease subunit PtsA; Provisional; Region: pstA; PRK11268 481805013825 Transmembrane subunit (TM) found in Periplasmic Binding Protein (PBP)-dependent ATP-Binding Cassette (ABC) transporters which generally bind type 2 PBPs. These types of transporters consist of a PBP, two TMs, and two cytoplasmic ABC ATPase subunits, and...; Region: TM_PBP2; cd06261 481805013826 dimer interface [polypeptide binding]; other site 481805013827 conserved gate region; other site 481805013828 putative PBP binding loops; other site 481805013829 ABC-ATPase subunit interface; other site 481805013830 phosphate transporter ATP-binding protein; Provisional; Region: pstB; PRK10744 481805013831 ATP-binding cassette domain of the phosphate transport system; Region: ABC_PstB_phosphate_transporter; cd03260 481805013832 Walker A/P-loop; other site 481805013833 ATP binding site [chemical binding]; other site 481805013834 Q-loop/lid; other site 481805013835 ABC transporter signature motif; other site 481805013836 Walker B; other site 481805013837 D-loop; other site 481805013838 H-loop/switch region; other site 481805013839 transcriptional regulator PhoU; Provisional; Region: PRK11115 481805013840 PhoU domain; Region: PhoU; pfam01895 481805013841 PhoU domain; Region: PhoU; pfam01895 481805013842 transcriptional antiterminator BglG; Provisional; Region: PRK09772 481805013843 CAT RNA binding domain; Region: CAT_RBD; pfam03123 481805013844 PRD domain; Region: PRD; pfam00874 481805013845 PRD domain; Region: PRD; pfam00874 481805013846 PTS system beta-glucoside-specific transporter subunits IIABC; Provisional; Region: PRK09824 481805013847 PTS_IIB, PTS system, glucose/sucrose specific IIB subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIB_glc; cd00212 481805013848 active site turn [active] 481805013849 phosphorylation site [posttranslational modification] 481805013850 Phosphotransferase system IIC components, glucose/maltose/N-acetylglucosamine-specific [Carbohydrate transport and metabolism]; Region: PtsG; COG1263 481805013851 PTS_IIA, PTS system, glucose/sucrose specific IIA subunit. The bacterial phosphoenolpyruvate: sugar phosphotransferase system (PTS) is a multi-protein system involved in the regulation of a variety of metabolic and transcriptional processes. This family...; Region: PTS_IIA_glc; cd00210 481805013852 HPr interaction site; other site 481805013853 glycerol kinase (GK) interaction site [polypeptide binding]; other site 481805013854 active site 481805013855 phosphorylation site [posttranslational modification] 481805013856 Beta-glucosidase/6-phospho-beta-glucosidase/beta- galactosidase [Carbohydrate transport and metabolism]; Region: BglB; COG2723 481805013857 beta-galactosidase; Region: BGL; TIGR03356 481805013858 Maltoporin periplasmic N-terminal extension; Region: Sugarporin_N; pfam11471 481805013859 The Maltoporin-like channels (LamB porin) form a trimeric structure which facilitate the diffusion of maltodextrins and other sugars across the outer membrane of Gram-negative bacteria. The membrane channel is formed by an 18-strand antiparallel...; Region: Maltoporin-like; cd01346 481805013860 trimer interface; other site 481805013861 sugar binding site [chemical binding]; other site 481805013862 N-terminal Early set domain associated with the catalytic domain of putative esterases; Region: E_set_Esterase_like_N; cd11294 481805013863 Enterochelin esterase and related enzymes [Inorganic ion transport and metabolism]; Region: Fes; COG2382 481805013864 Predicted hydrolase of the alpha/beta superfamily [General function prediction only]; Region: COG2819 481805013865 6-phosphogluconolactonase/Glucosamine-6-phosphate isomerase/deaminase [Carbohydrate transport and metabolism]; Region: NagB; COG0363 481805013866 GlcN6P_deaminase: Glucosamine-6-phosphate (GlcN6P) deaminase subfamily; GlcN6P deaminase catalyzes the reversible conversion of GlcN6P to D-fructose-6-phosphate (Fru6P) and ammonium. The reaction is an aldo-keto isomerization coupled with an amination or...; Region: GlcN6P_deaminase; cd01399 481805013867 active site 481805013868 trimer interface [polypeptide binding]; other site 481805013869 allosteric site; other site 481805013870 active site lid [active] 481805013871 Uncharacterized protein family (UPF0167); Region: UPF0167; cl01252 481805013872 putative inner membrane protein; Provisional; Region: PRK09823 481805013873 6-phosphogluconate phosphatase; Provisional; Region: PRK10563 481805013874 Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogenase, epoxide hydrolase, phosphoserine phosphatase, phosphomannomutase, phosphoglycolate phosphatase, P-type ATPase, and many others; Region: HAD_like; cd01427 481805013875 active site 481805013876 motif I; other site 481805013877 motif II; other site 481805013878 Xanthine/uracil/vitamin C permease [Nucleotide transport and metabolism]; Region: COG2252 481805013879 Predicted flavoprotein [General function prediction only]; Region: COG0431 481805013880 NADPH-dependent FMN reductase; Region: FMN_red; pfam03358 481805013881 Phosphopantetheinyl transferase [Coenzyme metabolism]; Region: Sfp; COG2091 481805013882 DNA-binding transcriptional regulator YidZ; Provisional; Region: PRK10216 481805013883 Bacterial regulatory helix-turn-helix protein, lysR family; Region: HTH_1; pfam00126 481805013884 The C-terminal substrate binding domain of LysR-type transcriptional regulators that involved in the catabolism of nitroaromatic/naphthalene compounds and that of related regulators; contains the type 2 periplasmic binding fold; Region: PBP2_Nitroaromatics_like; cd08417 481805013885 substrate binding pocket [chemical binding]; other site 481805013886 dimerization interface [polypeptide binding]; other site 481805013887 multidrug efflux system protein MdtL; Provisional; Region: PRK10473 481805013888 The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of...; Region: MFS; cd06174 481805013889 putative substrate translocation pore; other site 481805013890 tryptophan permease TnaB; Provisional; Region: PRK09664 481805013891 aromatic amino acid transport protein; Region: araaP; TIGR00837 481805013892 tryptophanase, leader peptide-associated; Region: tnaA_trp_ase; TIGR02617 481805013893 Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the...; Region: AAT_I; cl00321 481805013894 pyridoxal 5'-phosphate binding pocket [chemical binding]; other site 481805013895 catalytic residue [active] 481805013896 Tryptophanese operon leader peptide; Region: Tna_leader; pfam08053 481805013897 tRNA modification GTPase TrmE; Reviewed; Region: trmE; PRK05291 481805013898 GTP-binding protein TrmE N-terminus; Region: TrmE_N; pfam10396 481805013899 trmE is a tRNA modification GTPase; Region: trmE; cd04164 481805013900 G1 box; other site 481805013901 GTP/Mg2+ binding site [chemical binding]; other site 481805013902 Switch I region; other site 481805013903 G2 box; other site 481805013904 Switch II region; other site 481805013905 G3 box; other site 481805013906 G4 box; other site 481805013907 G5 box; other site 481805013908 Catalytic cysteine-containing C-terminus of GTPase, MnmE; Region: GTPase_Cys_C; pfam12631 481805013909 membrane protein insertase; Provisional; Region: PRK01318 481805013910 membrane protein insertase, YidC/Oxa1 family, C-terminal domain; Region: yidC_oxa1_cterm; TIGR03592 481805013911 hypothetical protein; Validated; Region: PRK00041 481805013912 ribonuclease P; Reviewed; Region: rnpA; PRK01732 481805013913 50S ribosomal protein L34; Reviewed; Region: rpmH; PRK00399