-- dump date 20140619_081638 -- class Genbank::CDS -- table cds_note -- id note YP_002925203.1 involved in threonine biosynthesis; controls the expression of the thrLABC operon YP_002925204.1 multifunctional homotetrameric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_002925205.1 catalyzes the formation of O-phospho-L-homoserine from L-homoserine in threonine biosynthesis from asparate YP_002925206.1 catalyzes the formation of L-threonine from O-phospho-L-homoserine YP_002925207.1 MG1655 equivalent: b0005 YP_002925208.1 MG1655 equivalent: b0006 YP_002925209.1 MG1655 equivalent: b0007 YP_002925210.1 MG1655 equivalent: b0008 YP_002925211.1 forms a trimer; related to eukaryotic protein gephyrin; functions during molybdenum cofactor biosynthesis YP_002925212.1 MG1655 equivalent: b0010 YP_002925213.1 MG1655 equivalent: b0011 YP_002925214.1 MG1655 equivalent: b0013 YP_002925215.1 heat shock protein 70; assists in folding of nascent polypeptide chains; refolding of misfolded proteins; utilizes ATPase activity to help fold; co-chaperones are DnaJ and GrpE; multiple copies in some bacteria YP_002925216.1 chaperone Hsp40; co-chaperone with DnaK; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, dnaK-independent fashion YP_002925217.1 MG1655 equivalent: b0016 YP_002925218.1 MG1655 equivalent: b0018 YP_002925219.1 MG1655 equivalent: b4412 YP_002925220.1 exports sodium by using the electrochemical proton gradient to allow protons into the cell; functions in adaptation to high salinity and alkaline pH; activity increases at higher pH; downregulated at acidic pH YP_002925221.1 Na+/H+ antiporter regulatory protein; activates the genes nhaA and osmC YP_002925222.1 MG1655 equivalent: b0021 YP_002925223.1 MG1655 equivalent: b0022 YP_002925224.1 binds directly to the 16S rRNA and is involved in post-translational inhibition of arginine and ornithine decarboxylase YP_002925225.1 MG1655 equivalent: b0024 YP_002925226.1 catalyzes the formation of FMN from riboflavin and the formation of FAD from FMN; in Bacillus the ribC gene has both flavokinase and FAD synthetase activities YP_002925227.1 IleRS; catalyzes the formation of isoleucyl-tRNA(Ile) from isoleucine and tRNA(Ile); since isoleucine and other amino acids such as valine are similar, there are additional editing function in this enzyme; one is involved in hydrolysis of activated valine-AMP and the other is involved in deacylation of mischarged Val-tRNA(Ile); there are two active sites, one for aminoacylation and one for editing; class-I aminoacyl-tRNA synthetase family type 1 subfamily; some organisms carry two different copies of this enzyme YP_002925228.1 lipoprotein signal peptidase; integral membrane protein that removes signal peptides from prolipoproteins during lipoprotein biosynthesis YP_002925229.1 MG1655 equivalent: b0028 YP_002925230.1 catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate into isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP); functions in the nonmevalonate isoprenoid biosynthesis pathway YP_002925231.1 catalyzes the hydrolysis of both purine and pyrimidine ribonucleosides YP_002925232.1 catalyzes the reduction of 2,3-dihydrodipicolinate to 2,3,4,5-tetrahydrodipicolinate in lysine and diaminopimelate biosynthesis YP_002925233.1 catalyzes production of carbamoyl phosphate from bicarbonate and glutamine in pyrimidine and arginine biosynthesis pathways; forms an octamer composed of four CarAB dimers YP_002925234.1 four CarB-CarA dimers form the carbamoyl phosphate synthetase holoenzyme that catalyzes the production of carbamoyl phosphate; CarB is responsible for the amidotransferase activity YP_002925235.1 regulator of carnitine metabolism; induces the caiTABCDE and fixABCX operons YP_002925236.1 involved in the synthesis of a cofactor required for carnitine dehydratase and carnitine racemase activities YP_002925237.1 catalyzes the dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA YP_002925238.1 MG1655 equivalent: b0037 YP_002925239.1 catalyzes formation of L-carnitinyl-CoA by transfering the CoA moiety from gamma-butyrobetainyl-CoA, also catalyzes the formation of crotonobetainyl-CoA by transfer of CoA from gamma-butyrobetainyl-CoA or L-carnitinyl-CoA to crotonobetaine YP_002925240.1 catalyzes the reduction of crotonobetainyl-CoA to gamma-butyrobetainyl-CoA YP_002925241.1 catalyzes the exchange of L-carnitine for gamma-butyrobetaine in carnitine metabolism YP_002925242.1 required for anaerobic carnitine reduction, may act to transfer electrons to crotonobetaine reductase YP_002925243.1 involved in electron transfer during carnitine metabolism YP_002925244.1 FAD/NAD(P)-binding domain; possibly part of an electron transfer system required for anaerobic carnitine reduction YP_002925245.1 MG1655 equivalent: b0044 YP_002925246.1 MG1655 equivalent: b0045 YP_002925247.1 Required for full activity of KefC, a potassium-proton antiporter YP_002925248.1 transport system that facilitates potassium-efflux YP_002925249.1 catalyzes the reduction of dihydrofolate to tetrahydrofolate YP_002925250.1 hydrolyzes P(1),P(4)-bis(5'-adenosyl) tetraphosphate to form 2 ADP YP_002925251.1 protein associated with Co2+ and Mg2+ efflux YP_002925252.1 catalyzes the transfer of a total of four methyl groups from S-adenosyl-l-methionine (S-AdoMet) to two adjacent adenosine bases A1518 and A1519 in 16S rRNA; mutations in ksgA causes resistance to the translation initiation inhibitor kasugamycin YP_002925253.1 catalyzes oxidation of 4-(phosphohydroxy)-L-threonine into 2-amino-3-oxo-4-(phosphohydroxy)butyric acid which decarboxylates to form 1-amino-3-(phosphohydroxy)propan-2-one (3-amino-2-oxopropyl phosphate) YP_002925254.1 Chaperone involved in the folding of extracytoplasmic proteins, especially OmpA, OmpF and LamB YP_002925255.1 determines N-hexane tolerance and is involved in outer membrane permeability YP_002925256.1 functions as a co-chaperone with DnaK; involved in regulation of colanic acid capsule; inner membrane protein; dimerized via transmembrane domain; J-like domain is cytoplasmic and can functionally substitute for DnaJ; stimulates synthesis of colanic acid mucoid capsule through the RcsB/C signal transduction system YP_002925257.1 catalyzes the synthesis of pseudouridine from uracil-746 in 23S ribosomal RNA and from uracil-32 in the anticodon stem and loop of transfer RNAs YP_002925258.1 transcription regulator that activates transcription by stimulating RNA polymerase (RNAP) recycling in case of stress conditions such as supercoiled DNA or high salt concentrations. Probably acts by releasing the RNAP, when it is trapped or immobilized on tightly supercoiled DNA YP_002925259.1 Has polymerase, DNA-binding and 3'-5' exonuclease activities. In Aeropyrum pernix this protein is sensitive to aphidicolin and stable at 95#C YP_002925260.1 catalyzes the formation of L-ribulose from L-arabinose in L-arabinose catabolism YP_002925261.1 catalyzes the phosphorylation of ribulose to ribulose 5-phosphate YP_002925262.1 positive and negative regulator; regulates the araBAD and araFGH operons and other genes involved in the transport and catabolism of L-arabinose YP_002925263.1 MG1655 equivalent: b0065 YP_002925264.1 with TbpA and ThiP is part of the thiamine and TPP transport system YP_002925265.1 permease; with TbpA and ThiQ functions in transport of thiamine and thiamine pyrophosphate into the cell; repressed in presence of exogenous thiamine YP_002925266.1 part of the thiamine and TPP transport system tbpA-thiPQ YP_002925267.1 activates sgrS under glucose-phosphate stress conditions YP_002925268.1 MG1655 equivalent: b0070 YP_002925269.1 catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate in leucine biosynthesis; forms a heterodimer of LeuC/D YP_002925270.1 dehydratase component, catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate YP_002925271.1 catalyzes the oxidation of 3-isopropylmalate to 3-carboxy-4-methyl-2-oxopentanoate in leucine biosynthesis YP_002925272.1 catalyzes the formation of 2-isopropylmalate from acetyl-CoA and 2-oxoisovalerate in leucine biosynthesis YP_002925273.1 involved in attenuation control of the leuABCD operon in leucine biosynthesis YP_002925274.1 activator for leuABCD operon; member of LysR family of transcriptional activators YP_002925275.1 catalyzes the formation of 2-acetolactate from pyruvate, leucine sensitive YP_002925276.1 with IlvI catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase 3 small subunit YP_002925277.1 binds D-fructose as an inducer; involved in regulation of operons for central pathways of carbon metabolism YP_002925278.1 MraZ; UPF0040; crystal structure shows similarity to AbrB YP_002925279.1 MG1655 equivalent: b0082 YP_002925280.1 membrane bound cell division protein at septum containing leucine zipper motif YP_002925281.1 MG1655 equivalent: b0084 YP_002925282.1 involved in cell wall formation; peptidoglycan synthesis; cytoplasmic enzyme; catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-aceylmuramoyl-l-alanyl-d-glutamate YP_002925283.1 MG1655 equivalent: b0086 YP_002925284.1 First step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan YP_002925285.1 UDP-N-acetylmuramoylalanine--D-glutamate ligase; involved in peptidoglycan biosynthesis; cytoplasmic; catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine during cell wall formation YP_002925286.1 integral membrane protein involved in stabilizing FstZ ring during cell division YP_002925287.1 UDP-N-acetylglucosamine--N-acetylmuramyl- (pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase; involved in cell wall formation; inner membrane-associated; last step of peptidoglycan synthesis YP_002925288.1 Catalyzes the formation of UDP-N-acetylmuramoyl-L-alanine from UDP-N-acetylmuramate and L-alanine in peptidoglycan synthesis YP_002925289.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_002925290.1 involved in septum formation YP_002925291.1 ATP-binding involved in recruitment of FtsK to Z ring; essential cell division protein; colocalizes with FtsZ through direct interaction to the septal ring structure; structurally similar to eukaryotic actin; binds directly to the cell membrane YP_002925292.1 GTPase; similar structure to tubulin; forms ring-shaped polymers at the site of cell division; other proteins such as FtsA, ZipA, and ZapA, interact with and regulate FtsZ function YP_002925293.1 zinc-dependent; catalyzes the deacetylation of UDP-(3-O-acyl)-N-acetylglucosamine to UDP-3-O-(3-hydroxytetradecanoyl)-glucosamine in the second step of lipid A biosynthesis YP_002925294.1 secM translational pause allows for the initiation of secA translation YP_002925295.1 functions in protein export; can interact with acidic membrane phospholipids and the SecYEG protein complex; binds to preproteins; binds to ATP and undergoes a conformational change to promote membrane insertion of SecA/bound preprotein; ATP hydrolysis appears to drive release of the preprotein from SecA and deinsertion of SecA from the membrane; additional proteins SecD/F/YajC aid SecA recycling; exists in an equilibrium between monomers and dimers; may possibly form higher order oligomers; proteins in this cluster correspond SecA1; SecA2 is not essential and seems to play a role in secretion of a subset of proteins YP_002925296.1 MG1655 equivalent: b0099 YP_002925297.1 MG1655 equivalent: b0101 YP_002925298.1 MG1655 equivalent: b0102 YP_002925299.1 catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A; involved in coenzyme A biosynthesis YP_002925300.1 catalyzes the NADPH-dependent deamination of GMP to inosine monophosphate YP_002925301.1 MG1655 equivalent: b0106 YP_002925302.1 MG1655 equivalent: b0107 YP_002925303.1 MG1655 equivalent: b0108 YP_002925304.1 catalyzes the formation of pyridine-2,3-dicarboxylate and 5-phospho-alpha-D-ribose 1-diphosphate from nictinate D-ribonucleotide YP_002925305.1 MG1655 equivalent: b0110 YP_002925306.1 involved in regulation of beta-lactamase; putative signaling protein YP_002925307.1 MG1655 equivalent: b0112 YP_002925308.1 activates lctPRD operon; autoregulates itself through repression of pdhR-aceEF-lpdA operon; regulates pyruvate dehydrogenase complex YP_002925309.1 E1 component; part of pyruvate dehydrogenase; forms a complex with DlaT and LpdC YP_002925310.1 E2 component of pyruvate dehydrogenase multienzyme complex; in Escherichia coli AceF contains three N-terminal lipoyl domains YP_002925311.1 E3 component of pyruvate and 2-oxoglutarate dehydrogenase complex; catalyzes the oxidation of dihydrolipoamide to lipoamide YP_002925312.1 MG1655 equivalent: b0117 YP_002925313.1 catalyzes the conversion of citrate to isocitrate and the conversion of 2-methylaconitate to 2-methylisocitrate YP_002925314.1 MG1655 equivalent: b0119 YP_002925315.1 S-adenosylmethionine provides the aminopropyl moiety required for spermidine biosynthesis from putrescine YP_002925316.1 catalyzes the formation of spermidine from putrescine and S-adenosylmethioninamine YP_002925317.1 MG1655 equivalent: b0122 YP_002925318.1 laccase; copper-stimulated phenoloxidase and ferroxidase which may be involved in copper detoxification YP_002925319.1 MG1655 equivalent: b0124 YP_002925320.1 MG1655 equivalent: b0125 YP_002925321.1 catalyzes the interconversion of bicarbonate and carbon dioxide YP_002925322.1 MG1655 equivalent: b0127 YP_002925323.1 MG1655 equivalent: b0128 YP_002925324.1 MG1655 equivalent: b0129 YP_002925325.1 MG1655 equivalent: b0130 YP_002925326.1 Converts L-aspartate to beta-alanine and provides the major route of beta-alanine production in bacteria. Beta-alanine is essential for the biosynthesis of pantothenate (vitamin B5) YP_002925327.1 MG1655 equivalent: b0132 YP_002925328.1 catalyzes the formation of (R)-pantothenate from pantoate and beta-alanine YP_002925329.1 catalyzes the formation of tetrahydrofolate and 2-dehydropantoate from 5,10-methylenetetrahydrofolate and 3-methyl-2-oxobutanoate YP_002925330.1 MG1655 equivalent: b0135 YP_002925331.1 MG1655 equivalent: b0136 YP_002925332.1 MG1655 equivalent: b0137 YP_002925333.1 MG1655 equivalent: b0138 YP_002925334.1 similar to the fimbrial usher protein PapC YP_002925335.1 MG1655 equivalent: b0140 YP_002925336.1 MG1655 equivalent: b0141 YP_002925337.1 catalyzes the formation of 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine and ATP YP_002925338.1 Polymerase that creates the 3' poly(A) tail found in some mRNA's YP_002925339.1 this tRNA synthetase lacks the tRNA anticodon interaction domain; instead this enzyme modifies tRNA(Asp) with glutamate by esterifying glutamate to the 2-amino-5-(4,5-dihydroxy-2-cyclopenten-1-yl) moiety of queosine generating a modified nucleoside at the first anticodon position of tRNAAsp; the modified tRNA does not bind elongation factor Tu YP_002925340.1 MG1655 equivalent: b0145 YP_002925341.1 Regulatory factor involved in maltose metabolism YP_002925342.1 MG1655 equivalent: b0147 YP_002925343.1 similar in sequence to the ATP-dependent RNA helicase HrpA YP_002925344.1 bifunctional periplasmic enzyme; contains transglycosylase and transpeptidase activity; major enzyme for peptidoglycan biosynthesis in Escherichia coli; transmembrane protein; forms dimers; three variants, one of which may be a degradation product, while the other appears to result from an alternative initiation site, are found within the cell YP_002925345.1 involved with the transport of ferrichrome across the outer membrane; binds the ferrichrome-iron ligand and interacts with the TonB protein YP_002925346.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter YP_002925347.1 Part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter; binds to all hydroxamate siderophores YP_002925348.1 part of the FhuBCD ATP-dependent iron (III) hydroxamate transporter involved in the high-affinity transport of Fe(3+)-ferrichrome YP_002925349.1 Converts (S)-4-amino-5-oxopentanoate to 5-aminolevulinate during the porphyrin biosynthesis pathway YP_002925350.1 Acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation YP_002925351.1 essential respiratory protein A; may be involved in the transfer of iron-sulfur clusters; essential for growth using oxygen or alternate electron acceptors YP_002925352.1 MG1655 equivalent: b0157 YP_002925353.1 solute binding component of the vitamin B12 transport system BtuCDF YP_002925354.1 enables the cleavage of the glycosidic bond in both 5'-methylthioadenosine and S-adenosylhomocysteine YP_002925355.1 forms a homotetramer; requires magnesium for activity; catalyzes the hydrolysis of dGTP to form deoxyguanosine and triphosphate YP_002925356.1 protease Do; required at high temperature; degrades damaged proteins YP_002925357.1 regulates the expression of the operons for the enzymes involved in galactarate, glucarate and glycerate utilization YP_002925358.1 MG1655 equivalent: b0163 YP_002925359.1 MG1655 equivalent: b0164 YP_002925360.1 catalyzes the formation of N-succinyl-2-amino-6-ketopimelate from succinyl-CoA and tetrahydrodipicolinate in the lysine biosynthetic pathway YP_002925361.1 catalyzes the uridylylation or deuridylylation of the PII nitrogen regulatory protein YP_002925362.1 catalyzes the removal of N-terminal amino acids from peptides and arylamides; generally Co(II) however activity has been shown for some methionine aminopeptidases with Zn, Fe, or Mn YP_002925363.1 one of the last subunits in the assembly of the 30S subunit; absence of S2 does not inhibit assembly but results in an inactive subunit YP_002925364.1 EF-Ts; functions during elongation stage of protein translation; forms a dimer; associates with EF-Tu-GDP complex and promotes exchange of GDP to GTP resulting in regeneration of the active form of EF-Tu YP_002925365.1 Catalyzes the phosphorylation of UMP to UDP YP_002925366.1 Rrf; Frr; ribosome-recycling factor; release factor 4; RF4; recycles ribosomes upon translation termination along with release factor RF-3 and elongation factor EF-G; A GTPase-dependent process results in release of 50S from 70S; inhibited by release factor RF-1; essential for viability; structurally similar to tRNAs YP_002925367.1 catalyzes the NADP-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate YP_002925368.1 catalyzes the formation of undecaprenyl pyrophosphate from isopentenyl pyrophosphate YP_002925369.1 catalyzes the synthesis of CDP-diglyceride from CTP and phosphatidate YP_002925370.1 catalyzes the cleavage of RseA which activates the sigmaE-mediated stress response YP_002925371.1 part of a complex with YfgL, YfiO, and NlpB involved in outer membrane protein biosynthesis; involved in the assembly of outer membrane proteins YP_002925372.1 MG1655 equivalent: b0178 YP_002925373.1 adds the O-linked and N-linked 3(R)-hydroxy fatty acids to the glucosamine disaccharide during lipid A biosynthesis YP_002925374.1 in Pseudomonas aeruginosa this enzyme is a trimer of dimers; essential for membrane formation; performs third step of type II fatty acid biosynthesis; catalyzes dehydration of (3R)-hydroxyacyl-ACP to trans-2-acyl-ACP YP_002925375.1 catalyzes the addition of (R)-3-hydroxytetradecanoyl to the glucosamine disaccharide in lipid A biosynthesis YP_002925376.1 catalyzes the formation of lipid A disaccharide from UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate, lipid A disaccharide is a precursor of lipid A that anchors LPS to the OM YP_002925377.1 RNH2; RNase HII; binds manganese; endonuclease which specifically degrades the RNA of RNA-DNA hybrids YP_002925378.1 catalyzes DNA-template-directed extension of the 3'- end of a DNA strand by one nucleotide at a time; main replicative polymerase YP_002925379.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer composed of two alpha (AccA) and two beta (AccD) subunits; one of the two catalytic subunits that can form the acetyl CoA carboxylase enzyme together with a carrier protein YP_002925380.1 MG1655 equivalent: b0186 YP_002925381.1 MG1655 equivalent: b0187 YP_002925382.1 Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU; ATP-dependent; responsible for modifying the wobble-base of the CAU anticodon of tRNAIle such that it exhibits proper recognition of the AUA codon rather than the AUG codon and is in turn properly recognized by isoleucyl-tRNA synthetase YP_002925383.1 Suppresses temperature-sensitive mutations in essential genes by modulating rho-dependent transcription termination YP_002925384.1 MG1655 equivalent: b4406 YP_002925385.1 MG1655 equivalent: b0190 YP_002925386.1 MG1655 equivalent: b0191 YP_002925387.1 MG1655 equivalent: b0192 YP_002925388.1 MG1655 equivalent: b0193 YP_002925389.1 catalyzes the formation of prolyl-tRNA(Pro) from proline and tRNA(Pro) YP_002925390.1 MG1655 equivalent: b0195 YP_002925391.1 MG1655 equivalent: b0196 YP_002925392.1 MG1655 equivalent: b0197 YP_002925393.1 part of the MetNIQ methionine uptake system YP_002925394.1 part of the metNIQ transport system for methionine YP_002925395.1 Converts the D-glycero-beta-D-manno-heptose 1,7-bisphosphate intermediate into D-glycero-beta-D-manno-heptose 1-phosphate YP_002925396.1 catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid YP_002925397.1 MG1655 equivalent: b0208 YP_002925398.1 MG1655 equivalent: b0209 YP_002925399.1 MG1655 equivalent: b0210 YP_002925400.1 catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues; may play a role in recycling muropeptides during cell division and/or cell elongation; in Helicobacter pylori MltD is a endolytic transglycosylase involved mainly in the rearrangement of the peptidoglycan layer of the bacterial cell wall YP_002925401.1 catalyzes the hydrolysis of S-D-lactoylglutathione to D-lactic acid and reduced glutathione; plays an important role in cellular detoxification using glutathione YP_002925402.1 MG1655 equivalent: b0213 YP_002925403.1 An endonuclease that specifically degrades the RNA strand of RNA-DNA hybrids YP_002925404.1 3'-5' exonuclease of DNA polymerase III YP_002925405.1 MG1655 equivalent: b0217 YP_002925406.1 MG1655 equivalent: b4586 YP_002925407.1 MG1655 equivalent: b0219 YP_002925408.1 inactivates vertebrate C-type lysozyme YP_002925409.1 functions in fatty acid oxidation; converts acyl-CoA and FAD to FADH2 and delta2-enoyl-CoA YP_002925410.1 catalyzes the isomerization of sedoheptulose 7-phosphate to D-glycero-D-manno-heptose 7-phosphate YP_002925411.1 MG1655 equivalent: b0223 YP_002925412.1 MG1655 equivalent: b0224 YP_002925413.1 MG1655 equivalent: b0225 YP_002925414.1 MG1655 equivalent: b0226 YP_002925415.1 MG1655 equivalent: b0227 YP_002925416.1 MG1655 equivalent: b0228 YP_002925417.1 involved in translesion DNA polymerization with beta clamp of polymerase III; belongs to Y family of polymerases; does not contain proofreading function YP_002925418.1 MG1655 equivalent: b0232 YP_002925419.1 YafO overproduction induces toxicity; it is believed to be the toxin of a toxin-antitoxin pair; unknown function YP_002925420.1 MG1655 equivalent: b0234 YP_002925421.1 MG1655 equivalent: b0237 YP_002925422.1 catalyzes the conversion of guanine, xanthine and, to a lesser extent, hypoxanthine to GMP, XMP and IMP, respectively YP_002925423.1 forms a 1:1 complex with the unphosphorylated from of enzyme IIAGlc; FrsA may promote fermentation YP_002925424.1 involved in the expression of csgBA which is involved in curli formation; interacts with sigmaS YP_002925425.1 MG1655 equivalent: b0241 YP_002925426.1 catalyzes the formation of glutamate 5-phosphate from glutamate in proline biosynthesis YP_002925427.1 Catalyzes the phosphorylation of L-glutamate during the proline biosynthesis pathway YP_002925428.1 MG1655 equivalent: b0245 YP_002925429.1 MG1655 equivalent: b0246 YP_002925430.1 MG1655 equivalent: b4504 YP_002925431.1 MG1655 equivalent: b0247 YP_002925432.1 MG1655 equivalent: b0248 YP_002925433.1 MG1655 equivalent: b0249 YP_002925434.1 MG1655 equivalent: b0250 YP_002925435.1 MG1655 equivalent: b0251 YP_002925436.1 MG1655 equivalent: b0252 YP_002925437.1 MG1655 equivalent: b0253 YP_002925438.1 MG1655 equivalent: b0254 YP_002925439.1 MG1655 equivalent: b0256 YP_002925440.1 MG1655 equivalent: b0259 YP_002925441.1 MG1655 equivalent: b0350 YP_002925442.1 catalyzes the formation of acetyl-CoA from acetalaldehyde YP_002925443.1 catalyzes the formation of pyruvate and acetaldehyde from 4-hydroxy-2-ketovaleric acid; involved in the degradation of phenylpropionate YP_002925444.1 MG1655 equivalent: b0353 YP_002925445.1 MG1655 equivalent: b0354 YP_002925446.1 MG1655 equivalent: b0355 YP_002925447.1 MG1655 equivalent: b0356 YP_002925448.1 formaldehyde-induced negative regulator of the frmRAB operon YP_002925449.1 MG1655 equivalent: b0358 YP_002925450.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats YP_002925451.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats YP_002925452.1 MG1655 equivalent: b0363 YP_002925453.1 MG1655 equivalent: b0364 YP_002925454.1 with TauB and TauC is responsible for taurine uptake. YP_002925455.1 Part of the ABC transporter complex tauABC involved in taurine import YP_002925456.1 MG1655 equivalent: b0367 YP_002925457.1 catalyzes the conversion of taurine (2-aminoethanesulfonate) to sulfite and aminoacetaldehyde concurrently with the conversion of alpha-ketoglutarate to succinate and carbon dioxide; non-heme iron oxidase; allows the use of taurine as an alternative sulfur source; forms homodimers YP_002925458.1 catalyzes the formation of porphobilinogen from 5-aminolevulinate YP_002925459.1 MG1655 equivalent: b0372 YP_002925460.1 MG1655 equivalent: b0373 YP_002925461.1 MG1655 equivalent: b0375 YP_002925462.1 this protein has no known enzymatic function YP_002925463.1 in Escherichia coli SbmA is involved in uptake of microcin J25; functions along with FhuA, TonB, and ExbB/D in this capacity; in Sinorhizobium meliloti, BacA is essential and required for symbiosis; defects appear to affect the cell envelope YP_002925464.1 MG1655 equivalent: b0378 YP_002925465.1 MG1655 equivalent: b0379 YP_002925466.1 MG1655 equivalent: b0380 YP_002925467.1 D-alanine--D-alanine ligase; DdlA; DdlB; cytoplasmic; catalyzes the formation of D-alanyl-D-alanine from two D-alanines in peptidoglycan synthesis; there are two forms of this enzyme in Escherichia coli YP_002925468.1 MG1655 equivalent: b0382 YP_002925469.1 MG1655 equivalent: b0383 YP_002925470.1 MG1655 equivalent: b0384 YP_002925471.1 catalyzes the conversion of 2 GTP into c-di-GMP; adrA overexpression induces cellulose biosynthesis, cell adherence to abiotic surfaces and swimming and swarming motility; AdrA acts post-transcriptionally on the bcsABZC operon activating cellulose biosynthesis YP_002925472.1 catalyzes the formation of L-proline from pyrroline-5-carboxylate YP_002925473.1 MG1655 equivalent: b0387 YP_002925474.1 type II enzyme similar to type I but differentially regulated and with a lower Km; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_002925475.1 MG1655 equivalent: b0389 YP_002925476.1 MG1655 equivalent: b0390 YP_002925477.1 MG1655 equivalent: b0391 YP_002925478.1 Required for efficient pilin antigenic variation YP_002925479.1 catalyzes phosphorylation of fructose; cytosolic enzyme YP_002925480.1 member of the major facilitator superfamily (MFS) of transporters; unknown function; may be associated with transport or processing of arabinose polymers YP_002925481.1 with SbcD cleaves DNA hairpin structures; also has 5' single-strand endonuclease activity YP_002925482.1 with SbcC cleaves DNA hairpin structure, also has 5' single-strand endonuclease activity YP_002925483.1 two component response regulator for the phosphate regulon; PhoR phosphorylates PhoB YP_002925484.1 membrane-associated histidine protein kinase that phosphorylates phoB in response to environmental signals as part of the two-component phosphate regulatory system phoR/phoB YP_002925485.1 MG1655 equivalent: b0401 YP_002925486.1 cryptic permease that may be involved in the transport of proline across the inner membrane; in Salmonella typhimurium, the proY gene is silent unless overexpressed on a multicopy plasmid or activated by a proZ mutation YP_002925487.1 MG1655 equivalent: b0403 YP_002925488.1 Converts holo-ACP to apo-ACP by hydrolytic cleavage of the phosphopantetheine prosthetic group from ACP YP_002925489.1 Synthesizes oQ from preQ1 in a single S-adenosylmethionine-requiring step YP_002925490.1 Exchanges the guanine residue with 7-aminomethyl-7-deazaguanine in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr) YP_002925491.1 member of preprotein translocase; forms a heterotrimer with SecD and SecF; links the SecD/SecF/YajC/YidC complex with the SecY/SecE/SecG complex YP_002925492.1 part of the preprotein secretory system; when complexed with proteins SecF and YajC, SecDFyajC stimulates the proton motive force-driven protein translocation, and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane YP_002925493.1 forms a complex with SecD and YajC; SecDFyajC stimulates the proton motive force-driven protein translocation; seems to modulate the cycling of SecA by stabilizing its membrane-inserted state and appears to be required for the release of mature proteins from the extracytoplasmic side of the membrane; in some organisms, such as Bacillus subtilis, SecD is fused to SecF YP_002925494.1 MG1655 equivalent: b0410 YP_002925495.1 MG1655 equivalent: b0411 YP_002925496.1 MG1655 equivalent: b0412 YP_002925497.1 MG1655 equivalent: b0413 YP_002925498.1 riboflavin biosynthesis protein which catalyzes the deamination and reduction steps in the riboflavin biosynthesis pathway; catalyzes the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and the formation of 5-amino-6-(5-phosphoribosylamino)uracil from 5-amino-6-(5-phosphoribitylamino)uracil YP_002925499.1 RibE; 6,7-diimethyl-8-ribityllumazine synthase; DMRL synthase; lumazine synthase; beta subunit of riboflavin synthase; condenses 5-amino-6-(1'-D)-ribityl-amino-2,4(1H,3H)-pyrimidinedione with L-3,4-dihydrohy-2-butanone-4-phosphate to generate 6,6-dimethyl-8-lumazine (DMRL); riboflavin synthase then uses 2 molecules of DMRL to produce riboflavin (vitamin B12); involved in the last steps of riboflavin biosynthesis; forms a 60mer (icosahedral shell) in both Bacillus subtilis and Escherichia coli; in Bacillus subtilis this 60mer is associated with the riboflavin synthase subunit (alpha) while in Escherichia coli it is not YP_002925500.1 Regulates rRNA biosynthesis by transcriptional antitermination YP_002925501.1 catalyzes the formation of thiamine diphosphate from thiamine phosphate ant ATP YP_002925502.1 hydrolyzes phosphatidylglycerophosphate to produce phosphatidylglycerol and phosphate YP_002925503.1 MG1655 equivalent: b0419 YP_002925504.1 catalyzes the formation of 1-deoxy-D-xylulose 5-phosphate from pyruvate and D-glyceraldehyde 3-phosphate YP_002925505.1 MG1655 equivalent: b0421 YP_002925506.1 catalyzes the bidirectional exonucleolytic cleavage of DNA YP_002925507.1 Required for the synthesis of the thiazole moiety YP_002925508.1 MG1655 equivalent: b0424 YP_002925509.1 ketopantoate reductase; catalyzes the NADPH reduction of ketopantoate to pantoate; functions in pantothenate (vitamin B5) biosynthesis YP_002925510.1 putative nucleotide binding property based on structural studies of Haemophilus influenzae crystallized protein in PDB Accession Number 1IN0 and NMR studies of Escherichia coli YajQ; the YajQ protein from Pseudomonas synringae appears to play a role in activation of bateriophage phi6 segment L transcription YP_002925511.1 MG1655 equivalent: b0427 YP_002925512.1 converts protoheme IX and farnesyl diphosphate to heme O YP_002925513.1 MG1655 equivalent: b0429 YP_002925514.1 MG1655 equivalent: b0430 YP_002925515.1 MG1655 equivalent: b0431 YP_002925516.1 MG1655 equivalent: b0432 YP_002925517.1 in Escherichia coli this protein is a permease involved in peptidoglycan recycling; member of major facilitator superfamily; MFS; inner membrane protein YP_002925518.1 MG1655 equivalent: b0434 YP_002925519.1 positive transcriptional regulator of morphogenetic pathway; controlling several genes involved in oxidative stress, acid stress, heat shock, osmotic shock, and carbon-starvation stress YP_002925520.1 Tig; RopA; peptidyl-prolyl cis/trans isomerase; promotes folding of newly synthesized proteins; binds ribosomal 50S subunit; forms a homodimer YP_002925521.1 hydrolyzes proteins to small peptides; with the ATPase subunits ClpA or ClpX, ClpP degrades specific substrates YP_002925522.1 binds and unfolds substrates as part of the ClpXP protease YP_002925523.1 MG1655 equivalent: b0439 YP_002925524.1 histone-like DNA-binding protein YP_002925525.1 MG1655 equivalent: b0441 YP_002925526.1 MG1655 equivalent: b0442 YP_002925527.1 MG1655 equivalent: b0443 YP_002925528.1 YbaX; catalyzes the transformation of GTP to 7-cyano-7-deazaguanine (preQ0), as one of the early reactions of quenosine biosynthesis; quenosine is a modified nucleoside that occurs at the wobble position of GUN anticodons in tRNAs for Asn, Asp, Tyr, and His YP_002925529.1 MG1655 equivalent: b0445 YP_002925530.1 MG1655 equivalent: b0446 YP_002925531.1 MG1655 equivalent: b0447 YP_002925532.1 MG1655 equivalent: b0448 YP_002925533.1 MG1655 equivalent: b0449 YP_002925534.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II 2 prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II 2 is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA; functionally it is equivalent to protein P-II (GlnB), but itsexpression is driven by the presence of uridylyltransferase, nitrogen regulator I, and the absence of ammonia. YP_002925535.1 MG1655 equivalent: b0451 YP_002925536.1 MG1655 equivalent: b0452 YP_002925537.1 MG1655 equivalent: b0453 YP_002925538.1 MG1655 equivalent: b0454 YP_002925539.1 MG1655 equivalent: b0456 YP_002925540.1 MG1655 equivalent: b0457 YP_002925541.1 MG1655 equivalent: b0458 YP_002925542.1 MG1655 equivalent: b0459 YP_002925543.1 with Hns involved in transcriptional regulation of hemolysin; non-specific DNA-binding protein which affects the production of multiple proteins YP_002925544.1 MG1655 equivalent: b0461 YP_002925545.1 MG1655 equivalent: b0462 YP_002925546.1 MG1655 equivalent: b0463 YP_002925547.1 regulates the acrAB operon which is involved in susceptibility to dephalothin and cephaloridine YP_002925548.1 small mechanosensitive ion channel (MscS) that opens in response to stretch forces in the membrane lipid bilayer; maintains cell turgor through accumulation and release of potassium; large protein class of MscS YP_002925549.1 MG1655 equivalent: b0466 YP_002925550.1 PriC; protein involved in DNA replication; part of the primosome, a protein complex required to restart stalled replication forks; binds the complex formed by PriA, PriB and DNA; PriC-dependent primosome requires a gap to restart DNA replication; stimulates Rep activity at stalled forks YP_002925551.1 MG1655 equivalent: b0468 YP_002925552.1 catalyzes a salvage reaction resulting in the formation of AMP which is metabolically less costly than a de novo synthesis YP_002925553.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the tau chain serves as a scaffold to help in the dimerizaton of the alpha,epsilon and theta core complex; the gamma chain seems to interact with the delta and delta' subunits to transfer the beta subunit on the DNA YP_002925554.1 MG1655 equivalent: b0471 YP_002925555.1 involved in a recombinational process of DNA repair, independent of the recBC complex YP_002925556.1 molecular chaperone YP_002925557.1 essential enzyme that recycles AMP in active cells; converts ATP and AMP to two molecules of ADP YP_002925558.1 protoheme ferro-lyase; catalyzes the insertion of a ferrous ion into protoporphyrin IX to form protoheme; involved in protoheme biosynthesis; in some organisms this protein is membrane-associated while in others it is cytosolic YP_002925559.1 MG1655 equivalent: b0476 YP_002925560.1 MG1655 equivalent: b0477 YP_002925561.1 YbaL; member of the CPA-2 family of antiporters; uncharacterized protein YP_002925562.1 MG1655 equivalent: b0479 YP_002925563.1 catalyzes the degradation of periplasmic UDP-glucose to uridine, glucose-1-phosphate and inorganic phosphate; specific for uridine nucleotides YP_002925564.1 MG1655 equivalent: b0481 YP_002925565.1 MG1655 equivalent: b0482 YP_002925566.1 MG1655 equivalent: b0483 YP_002925567.1 MG1655 equivalent: b0484 YP_002925568.1 catalyzes the formation of glutamate from glutamine YP_002925569.1 MG1655 equivalent: b0486 YP_002925570.1 activator of copper-responsive regulon genes YP_002925571.1 MG1655 equivalent: b0488 YP_002925572.1 MG1655 equivalent: b0489 YP_002925573.1 MG1655 equivalent: b0490 YP_002925574.1 MG1655 equivalent: b0491 YP_002925575.1 MG1655 equivalent: b0492 YP_002925576.1 MG1655 equivalent: b0493 YP_002925577.1 MG1655 equivalent: b0494 YP_002925578.1 MG1655 equivalent: b0495 YP_002925579.1 MG1655 equivalent: b0496 YP_002925580.1 MG1655 equivalent: b0497 YP_002925581.1 MG1655 equivalent: b0498 YP_002925582.1 catalyzes the selenophosphate-dependent transfer of selenium from selenophosphate for conversion of 2-thiouridine to 2-selenouridine at the wobble position in tRNA YP_002925583.1 activator of the allDC-ylbA operon involved in allantoin utilization YP_002925584.1 catalyzes the formation of glyoxylate from (S)-ureidoglycolate YP_002925585.1 regulates operons involved in the utilization of allantoin YP_002925586.1 catalyzes the formation of 2-hydroxy-3-oxopropanoate (tartronate semialdehyde) from two molecules of glyoxylate YP_002925587.1 MG1655 equivalent: b0508 YP_002925588.1 MG1655 equivalent: b0509 YP_002925589.1 MG1655 equivalent: b0511 YP_002925590.1 Plays a crucial role on both purine and pyrimidine metabolism YP_002925591.1 MG1655 equivalent: b0513 YP_002925592.1 MG1655 equivalent: b0514 YP_002925593.1 MG1655 equivalent: b0515 YP_002925594.1 allantoate amidohydrolase and N-carbamoyl-L-amino acid amidohydrolase are very similar; the allantoate amidohydrolase from Escherichia coli forms a dimer and binds zinc ions for catalytic activity and catalyzes the conversion of allantoate to (S)-ureidoglycolate and ammonia; carbamoyl amidohydrolase from Bacillus sp. converts N-carbamoyl amino acids to amino acids, ammonia, and carbon dioxide YP_002925595.1 MG1655 equivalent: b0517 YP_002925596.1 multicopy suppressor of dominant negative ftsH mutations YP_002925597.1 MG1655 equivalent: b0520 YP_002925598.1 MG1655 equivalent: b0521 YP_002925599.1 With PurE catalyzes the conversion of aminoimidazole ribonucleotide to carboxyaminoimidazole ribonucleotide in the de novo purine nucleotide biosynthetic pathway YP_002925600.1 MG1655 equivalent: b0523 YP_002925601.1 catalyzes the formation of 2,3=diacylglucosamine 1-phosphate from UDP-2,3=diacylglucosamine YP_002925602.1 MG1655 equivalent: b0525 YP_002925603.1 catalyzes a two-step reaction; charges a cysteine by linking its carboxyl group to the alpha-phosphate of ATP then transfers the aminoacyl-adenylate to its tRNA YP_002925604.1 MG1655 equivalent: b0527 YP_002925605.1 MG1655 equivalent: b0528 YP_002925606.1 catalyzes the formation of 5,10-methenyltetrahydrofolate from 5,10-methylenetetrahydrofolate and subsequent formation of 10-formyltetrahydrofolate from 5,10-methenyltetrahydrofolate YP_002925607.1 MG1655 equivalent: b0530 YP_002925608.1 MG1655 equivalent: b0531 YP_002925609.1 MG1655 equivalent: b0532 YP_002925610.1 MG1655 equivalent: b0533 YP_002925611.1 MG1655 equivalent: b0534 YP_002925612.1 activates the production of the major fimbrae protein FimA YP_002925613.1 MG1655 equivalent: b0537 YP_002925614.1 MG1655 equivalent: b0540 YP_002925615.1 MG1655 equivalent: b0541 YP_002925616.1 member of the small MDR (multidrug resistance) family of transporters; in Escherichia coli this protein provides resistance against a number of positively charged compounds including ethidium bromide and erythromycin; proton-dependent secondary transporter which exchanges protons for compound translocation YP_002925617.1 MG1655 equivalent: b0544 YP_002925618.1 DLP12 prophage; similar to PEBP/RK1P protein family in eukaryotes that inhibits MEK phosphorylation by Raf-1; crystal structure suggests similar properties but exact function is unknown YP_002925619.1 MG1655 equivalent: b0546 YP_002925620.1 MG1655 equivalent: b4588 YP_002925621.1 DLP12 prophage YP_002925622.1 DLP12 prophage; conserved protein similar to phage 82 and lambda proteins YP_002925623.1 MG1655 equivalent: b0549 YP_002925624.1 DLP12 prophage; Holliday junction resolvase YP_002925625.1 MG1655 equivalent: b4509 YP_002925626.1 MG1655 equivalent: b0551 YP_002925627.1 MG1655 equivalent: b0552 YP_002925628.1 MG1655 equivalent: b0554 YP_002925629.1 MG1655 equivalent: b0555 YP_002925630.1 MG1655 equivalent: b0556 YP_002925631.1 MG1655 equivalent: b4510 YP_002925632.1 MG1655 equivalent: b0557 YP_002925633.1 MG1655 equivalent: b0558 YP_002925634.1 MG1655 equivalent: b0559 YP_002925635.1 MG1655 equivalent: b4589 YP_002925636.1 MG1655 equivalent: b0560 YP_002925637.1 MG1655 equivalent: b0564 YP_002925638.1 outer membrane protease; involved in virulence in many organisms; OmpT; IcsP; SopA; Pla; PgtE; omptin; in Escherichia coli OmpT can degrade antimicrobial peptides; in Yersinia Pla activates plasminogen during infection; in Shigella flexneria SopA cleaves the autotransporter IcsA YP_002925639.1 MG1655 equivalent: b0566 YP_002925640.1 MG1655 equivalent: b0567 YP_002925641.1 MG1655 equivalent: b0568 YP_002925642.1 MG1655 equivalent: b0569 YP_002925643.1 MG1655 equivalent: b0570 YP_002925644.1 response regulator in two-component regulatory system with CusS; regulates the copper efflux system YP_002925645.1 with CusA, CusB and CusF is part of a cation efflux system that mediates resistance to copper and silver YP_002925646.1 MG1655 equivalent: b0573 YP_002925647.1 with CusA, CusC and CusF is part of a cation efflux system that mediates resistance to copper and silver YP_002925648.1 MG1655 equivalent: b0575 YP_002925649.1 MG1655 equivalent: b0576 YP_002925650.1 MG1655 equivalent: b0577 YP_002925651.1 catalyzes the reduction of nitroaromatic compounds such as nitrofurazone, quinones and the anti-tumor agent CB1954; NAD(P)H-dependent; oxygen insensitive YP_002925652.1 MG1655 equivalent: b0579 YP_002925653.1 MG1655 equivalent: b0580 YP_002925654.1 ATP-dependent; carboxylate-amine ligase with weak glutamate--cysteine ligase activity YP_002925655.1 MG1655 equivalent: b4415 YP_002925656.1 MG1655 equivalent: b0582 YP_002925657.1 MG1655 equivalent: b0583 YP_002925658.1 Fep; Cbt; Cbr; FeuB; FepA; PfeA; IroN; BfeA; outer membrane receptor of ferric enterobactin and colicins B and D; interacts with the TonB-ExbBD complex which catalyzes the translocation of the siderophore to the periplasmic space YP_002925659.1 MG1655 equivalent: b0585 YP_002925660.1 MG1655 equivalent: b4511 YP_002925661.1 with EntB, EntD, and EntE forms the multienzyme complex enterobactin synthase; EntF is the serine activating enzyme which catalyzes the formation of the amide and ester bonds of the cyclic enterobactin YP_002925662.1 part of the ferric enterobactin transport system; necessary for enetrobactin uptake YP_002925663.1 with FepBDE is involved in the transport of ferric enterobactin YP_002925664.1 with FepBCD is involved in the transport of ferric enterobactin YP_002925665.1 with FepBCG is involved in the transport of ferric enterobactin YP_002925666.1 protein p43; inner membrane protein that exports enterobactin to the periplasmic space; member of the major facilitator superfamily (MFS) of transporters YP_002925667.1 with FepCDG is involved in the transport of ferric enterobactin YP_002925668.1 MG1655 equivalent: b0593 YP_002925669.1 bifunctional 2,3-dihydroxybenzoate-AMP ligase/S-dihydroxybenzoyltransferase; activates the carboxylate group of 2,3-dihydroxy-benzoate forming (2,3-dihydroxybenzoyl)adenylate then catalyzes the acylation of holo-entB with 2,3-dihydroxy-benzoate adenylate YP_002925670.1 MG1655 equivalent: b0595 YP_002925671.1 catalyzes the formation of 2,3-dihydroxybenzoate from 2,3-dihydro-2,3-dihydroxybenzoate; involved in the biosynthesis of siderophores, enterobactin, bacillibactin or vibriobactin YP_002925672.1 MG1655 equivalent: b0597 YP_002925673.1 MG1655 equivalent: b0598 YP_002925674.1 MG1655 equivalent: b4512 YP_002925675.1 member of the iron-containing alcohol dehydrogenase family; unknown function YP_002925676.1 catalyzes the transfer of an amino moiety YP_002925677.1 MG1655 equivalent: b0601 YP_002925678.1 MG1655 equivalent: b0602 YP_002925679.1 MG1655 equivalent: b0603 YP_002925680.1 Involved in disulfide bond formation YP_002925681.1 with AhpF catalyzes the conversion of alkyl hydroperoxides to their corresponding alcohols; AhpC reduced the hydroperoxide substrate YP_002925682.1 MG1655 equivalent: b0606 YP_002925683.1 MG1655 equivalent: b0607 YP_002925684.1 MG1655 equivalent: b0608 YP_002925685.1 Regulates the synthesis of nucleoside triphosphates for nucleic acid synthesis, CTP for lipid synthesis, and GTP for protein elongation YP_002925686.1 MG1655 equivalent: b0611 YP_002925687.1 MG1655 equivalent: b0612 YP_002925688.1 catalyzes the formation of 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA from ATP and 3-dephospho-CoA YP_002925689.1 2'-(5''-phosphoribosyl)-3'-dephospho-CoA transferase; holo-citrate lyase synthase; CitG forms the prosthetic group precursor 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA which is then transferred to apo-ACP by CitX to produce holo-ACP and pyrophosphate YP_002925690.1 MG1655 equivalent: b0615 YP_002925691.1 MG1655 equivalent: b0616 YP_002925692.1 acyl carrier protein; with CitE and CitF catalyzes the formation of oxaloacetate from citrate YP_002925693.1 MG1655 equivalent: b0618 YP_002925694.1 MG1655 equivalent: b0619 YP_002925695.1 regulates the expression of citAB in citrate fermentation YP_002925696.1 responsible for the transport of C4-dicarboxylates during anaerobic growth YP_002925697.1 catalyzes the transfer of palmitate to lipid A YP_002925698.1 member of the CspA family; constitutively expressed RNA/ssDNA-binding protein; functions in helping cells adapt to low temperature; aids nucleic acid melting; participates in gene regulation; can act as a transcription antiterminator YP_002925699.1 may be involved in chromosome condensation; overexpression in Escherichia coli protects against decondensation by camphor; overexpressing the protein results in an increase in supercoiling YP_002925700.1 TatE; similar to TatA and found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_002925701.1 catalyzes the radical-mediated insertion of two sulfur atoms into an acyl carrier protein (ACP) bound to an octanoyl group to produce a lipoyl group YP_002925702.1 MG1655 equivalent: b0629 YP_002925703.1 lipoyl/octanoyltransferase; catalyzes the transfer of the lipoyl/octanoyl moiety of lipoyl/octanoyl-ACP onto lipoate-dependent enzymes like pyruvate dehydrogenase and the glycine cleavage system H protein YP_002925704.1 MG1655 equivalent: b0631 YP_002925705.1 penicillin-binding protein 5; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors YP_002925706.1 MG1655 equivalent: b0633 YP_002925707.1 MG1655 equivalent: b0634 YP_002925708.1 MG1655 equivalent: b0635 YP_002925709.1 SPOUT methyltransferase family protein; crystal structure shows homodimer; in Escherichia coli this protein methylates pseudouridine at position 1915 of the 23S ribosomal RNA YP_002925710.1 MG1655 equivalent: b0637 YP_002925711.1 MG1655 equivalent: b0638 YP_002925712.1 transfers an adenyl group from ATP to NaMN to form nicotinic acid adenine dinucleotide (NaAD) which is then converted to the ubiquitous compound NAD by NAD synthetase; essential enzyme in bacteria YP_002925713.1 required for the assembly and function of the DNAX complex which is required for the assembly of the beta subunit onto primed DNA YP_002925714.1 rare lipoprotein B; involved in the assembly of LPS in the outer membrane YP_002925715.1 leucine--tRNA ligase; LeuRS; class-I aminoacyl-tRNA synthetase; charges leucine by linking carboxyl group to alpha-phosphate of ATP and then transfers aminoacyl-adenylate to its tRNA; due to the large number of codons that tRNA(Leu) recognizes, the leucyl-tRNA synthetase does not recognize the anticodon loop of the tRNA, but instead recognition is dependent on a conserved discriminator base A37 and a long arm; an editing domain hydrolyzes misformed products; in Methanothermobacter thermautotrophicus this enzyme associates with prolyl-tRNA synthetase YP_002925716.1 MG1655 equivalent: b0643 YP_002925717.1 MG1655 equivalent: b0644 YP_002925718.1 MG1655 equivalent: b0645 YP_002925719.1 MG1655 equivalent: b0646 YP_002925720.1 MG1655 equivalent: b0647 YP_002925721.1 MG1655 equivalent: b0648 YP_002925722.1 MG1655 equivalent: b0649 YP_002925723.1 MG1655 equivalent: b0650 YP_002925724.1 Hydrolyzes with equal efficiency cytidine or uridine to ribose and cytosine or uracil, respectively; pyrimidine-specific YP_002925725.1 MG1655 equivalent: b0652 YP_002925726.1 MG1655 equivalent: b0653 YP_002925727.1 MG1655 equivalent: b0654 YP_002925728.1 MG1655 equivalent: b0655 YP_002925729.1 MG1655 equivalent: b0656 YP_002925730.1 Transfers the fatty acyl group on membrane lipoproteins YP_002925731.1 MG1655 equivalent: b0658 YP_002925732.1 MG1655 equivalent: b0659 YP_002925733.1 MG1655 equivalent: b0660 YP_002925734.1 catalyzes the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine from N6-(dimethylallyl)adenosine (i(6)A) YP_002925735.1 catalyzes the formation of 2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinol from 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol; functions in the biosynthesis of ubiquinone or coenzyme Q YP_002925736.1 functions in asparagine biosynthesis; converts glutamine, aspartate, ATP, and water to glutamate, asparagine, pyrophosphate and AMP YP_002925737.1 MG1655 equivalent: b0675 YP_002925738.1 MG1655 equivalent: b0676 YP_002925739.1 catalyzes the formation of glucosamine 6-phosphate from N-acetylglucosamine 6-phosphate YP_002925740.1 catalyzes the reversible formation of fructose 6-phosphate from glucosamine 6-phosphate YP_002925741.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002925742.1 catalyzes a two-step reaction, first charging a glutamine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002925743.1 MG1655 equivalent: b0681 YP_002925744.1 MG1655 equivalent: b0682 YP_002925745.1 negatively regulates a number of operons that encode enzymes involved in iron transport; activated by manganese; forms a homodimer YP_002925746.1 MG1655 equivalent: b4637 YP_002925747.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_002925748.1 MG1655 equivalent: b0685 YP_002925749.1 MG1655 equivalent: b0686 YP_002925750.1 negative modulator of the initiation of chromosome replication YP_002925751.1 catalyzes the interconversion of alpha-D-glucose 1-phosphate to alpha-D-glucose 6-phosphate YP_002925752.1 MG1655 equivalent: b0689 YP_002925753.1 catalyzes the uptake of putrescine via a proton symport mechanism, as well as the efflux of putrescine by a putrescine/ornithine antiport system YP_002925754.1 MG1655 equivalent: b0693 YP_002925755.1 MG1655 equivalent: b4590 YP_002925756.1 response regulator in two-component regulatory system with KdpD; regulates the kdp operon involved in potassium transport YP_002925757.1 sensory histidine kinase in two-component regulatory system with KdpE; signal sensing protein YP_002925758.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP)system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions. The C subunit may be involved in assembly of the KDP complex YP_002925759.1 One of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002925760.1 catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002925761.1 one of the components of the high-affinity ATP-driven potassium transport (or KDP) system, which catalyzes the hydrolysis of ATP coupled with the exchange of hydrogen and potassium ions YP_002925762.1 MG1655 equivalent: b0699 YP_002925763.1 MG1655 equivalent: b0700 YP_002925764.1 MG1655 equivalent: b0702 YP_002925765.1 MG1655 equivalent: b0704 YP_002925766.1 MG1655 equivalent: b4514 YP_002925767.1 MG1655 equivalent: b0706 YP_002925768.1 MG1655 equivalent: b0707 YP_002925769.1 UV-induced DNA repair; converts cyclobutane-type pyrimidine dimers created during exposure to UV ratiation to monomers; light dependent YP_002925770.1 MG1655 equivalent: b0709 YP_002925771.1 MG1655 equivalent: b0710 YP_002925772.1 MG1655 equivalent: b0711 YP_002925773.1 MG1655 equivalent: b0712 YP_002925774.1 MG1655 equivalent: b0713 YP_002925775.1 5-formyluracil/5-hydroxymethyluracil DNA glycosylase; involved in base excision repair of DNA damaged by oxidation or by mutagenic agents; acts as DNA glycosylase that recognizes and removes damaged bases with a preference for oxidized pyrimidines; has apurinic/apyrimidinic lyase activity YP_002925776.1 MG1655 equivalent: b0715 YP_002925777.1 MG1655 equivalent: b0716 YP_002925778.1 MG1655 equivalent: b0717 YP_002925779.1 MG1655 equivalent: b0718 YP_002925780.1 MG1655 equivalent: b0719 YP_002925781.1 type II enzyme; in Escherichia coli this enzyme forms a trimer of dimers which is allosterically inhibited by NADH and competitively inhibited by alpha-ketoglutarate; allosteric inhibition is lost when Cys206 is chemically modified which also affects hexamer formation; forms oxaloacetate and acetyl-CoA and water from citrate and coenzyme A; functions in TCA cycle, glyoxylate cycle and respiration; enzyme from Helicobacter pylori is not inhibited by NADH YP_002925782.1 MG1655 equivalent: b0721 YP_002925783.1 MG1655 equivalent: b0722 YP_002925784.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol YP_002925785.1 part of four member succinate dehydrogenase enzyme complex that forms a trimeric complex (trimer of tetramers); SdhA/B are the catalytic subcomplex and can exhibit succinate dehydrogenase activity in the absence of SdhC/D which are the membrane components and form cytochrome b556; SdhC binds ubiquinone; oxidizes succinate to fumarate while reducing ubiquinone to ubiquinol; the catalytic subunits are similar to fumarate reductase YP_002925786.1 SucA; E1 component of the oxoglutarate dehydrogenase complex which catalyzes the formation of succinyl-CoA from 2-oxoglutarate; SucA catalyzes the reaction of 2-oxoglutarate with dihydrolipoamide succinyltransferase-lipoate to form dihydrolipoamide succinyltransferase-succinyldihydrolipoate and carbon dioxide YP_002925787.1 component of 2-oxoglutarate dehydrogenase complex; catalyzes the transfer of succinyl coenzyme A to form succinyl CoA as part of the conversion of 2-oxoglutarate to succinyl-CoA YP_002925788.1 catalyzes the interconversion of succinyl-CoA and succinate YP_002925789.1 Catalyzes the only substrate-level phosphorylation in the TCA cycle YP_002925790.1 regulates the succiny-lCoA synthetase operon YP_002925791.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_002925792.1 MG1655 equivalent: b0732 YP_002925793.1 MG1655 equivalent: b0733 YP_002925794.1 MG1655 equivalent: b0734 YP_002925795.1 MG1655 equivalent: b4515 YP_002925796.1 MG1655 equivalent: b0735 YP_002925797.1 catalyzes the hydrolysis of short chain aliphatic acyl-CoA thioesters; physiological role remains unknown; involved in phospholipid metabolism; part of the Tol/Pal system of proteins that are critical for maintaining the integrity of the cell envelope components YP_002925798.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_002925799.1 membrane spanning protein in TolA-TolQ-TolR complex; involved in the tonB-independent uptake of group A colicins YP_002925800.1 inner membrane component of 7 member Tol-Pal envelope-spanning complex; involved in maintaining cell envelope integrity; utilized by colicins and filamentous phages for import; interacts with TolB, Pal, and through TolB to various outer membrane porins YP_002925801.1 forms dimers; may be involved in cell envelope integrity; interacts with outer membrane proteins and with the C-terminal domain of inner membrane protein TolA YP_002925802.1 MG1655 equivalent: b0741 YP_002925803.1 periplasmic protein that interacts with TolA; the tol-pal system is probably involved in maintaining cell envelope integrity YP_002925804.1 3 different subfamilies; catalyzes the formation of quinolinate from iminoaspartate and dihydroxyacetone phosphate YP_002925805.1 MG1655 equivalent: b0751 YP_002925806.1 involved in zinc efflux across the cytoplasmic membrane YP_002925807.1 MG1655 equivalent: b0753 YP_002925808.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, phenylalanine sensitive YP_002925809.1 2,3-bisphosphoglycerate-dependent; catalyzes the interconversion of 2-phosphoglycerate to 3-phosphoglycerate YP_002925810.1 catalyzes the conversion of alpha-aldose to the beta-anomer; active on D-glucose, L-arabinose, D-xylose, D-galactose, maltose and lactose; links the metabolism of lactose and galactose YP_002925811.1 catalyzes the formation of alpha-D-galactose 1-phosphate from D-galactose in galactose metabolism YP_002925812.1 catalyzes the interconversion of UDP-galactose and galactose-1-P with UDP-galactose and glucose-1-P YP_002925813.1 MG1655 equivalent: b0759 YP_002925814.1 contains 2 ATP-binding cassettes; involved in the transport of molybdenum YP_002925815.1 represses the modABCD operon and activates the moaABCD and napFDAGHBC operons YP_002925816.1 MG1655 equivalent: b0762 YP_002925817.1 with ModCB is involved in the high-affinity transport of molybdate YP_002925818.1 part of ModCBA molybdate transporter; member of ABC superfamily; inner membrane component; regulated by repressor protein ModE YP_002925819.1 Part of the ABC transporter complex modABC involved in molybdenum import YP_002925820.1 YbhA; catalyzes the dephosphorylation of pyridoxal phosphate, fructose 1,6-bisphosphate, erythrose 4-phosphate and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; phosphotransferase activity observed when using monophosphates as phosphate donor; member of the haloacid dehalogenase-like hydrolases superfamily YP_002925821.1 catalyzes the hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate YP_002925822.1 MG1655 equivalent: b0768 YP_002925823.1 MG1655 equivalent: b0769 YP_002925824.1 MG1655 equivalent: b0770 YP_002925825.1 MG1655 equivalent: b0771 YP_002925826.1 outer membrane lipoprotein that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA; YbhC localizes to the cellular poles; member of pectinesterase family YP_002925827.1 YbhB; similar to rat and human kinase inhibitory proteins YP_002925828.1 catalyzes the formation of S-adenosyl-4-methylthionine-2-oxobutanoate and 7,8-diaminononanoate from S-adenosyl-L-methionine and 8-amino-7-oxononanoate YP_002925829.1 MG1655 equivalent: b0775 YP_002925830.1 catalyzes the formation of 8-amino-7-oxononanoate from 6-carboxyhexanoyl-CoA and L-alanine YP_002925831.1 putative methyltransferase; acyl carrier protein involved in an unidentified step in the synthesis of pimeloyl-CoA, a biotin precursor; member of the bio operon (bioABFCD); in Escherichia coli, bioC-null mutants require biotin for growth YP_002925832.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_002925833.1 MG1655 equivalent: b4591 YP_002925834.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. The beta-hairpin of the Uvr-B subunit is inserted between the strands, where it probes for the presence of a lesion YP_002925835.1 MG1655 equivalent: b0780 YP_002925836.1 together with moaC, is involved in the conversion of a guanosine derivative (GXP) into molybdopterin precursor Z YP_002925837.1 MG1655 equivalent: b0782 YP_002925838.1 MoaC; along with MoaA is involved in conversion of a guanosine derivative into molybdopterin precursor Z; involved in molybdenum cofactor biosynthesis YP_002925839.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_002925840.1 catalyzes the conversion of molybdopterin precursor Z into molybdopterin YP_002925841.1 MG1655 equivalent: b0786 YP_002925842.1 MG1655 equivalent: b0787 YP_002925843.1 MG1655 equivalent: b0788 YP_002925844.1 MG1655 equivalent: b0789 YP_002925845.1 MG1655 equivalent: b0790 YP_002925846.1 MG1655 equivalent: b0791 YP_002925847.1 MG1655 equivalent: b0792 YP_002925848.1 MG1655 equivalent: b0793 YP_002925849.1 MG1655 equivalent: b0794 YP_002925850.1 MG1655 equivalent: b0795 YP_002925851.1 MG1655 equivalent: b0796 YP_002925852.1 this helicase is not essential cell growth YP_002925853.1 MG1655 equivalent: b0798 YP_002925854.1 helicase involved in DNA repair and perhaps also replication YP_002925855.1 MG1655 equivalent: b0800 YP_002925856.1 MG1655 equivalent: b0801 YP_002925857.1 MG1655 equivalent: b0802 YP_002925858.1 MG1655 equivalent: b0803 YP_002925859.1 MG1655 equivalent: b0804 YP_002925860.1 Fiu; YbiL; porin involved in the uptake of iron complexed with catecholate siderophores (e.g. dihydroxybenzoylserine, dihydroxybenzoate) and beta lactam agents; Fiu interacts with TonB which provides the energy required for transport across the outer membrane; acts as a receptor for iron-siderophores and microcins E492, M, and H47; outer membrane protein YP_002925861.1 MG1655 equivalent: b0806 YP_002925862.1 MG1655 equivalent: b0807 YP_002925863.1 MG1655 equivalent: b0808 YP_002925864.1 similar to ATP-binding component of ABC transporters YP_002925865.1 similar to permease component of ABC transporters; mutations impair ability of Escherichia coli to transport and utilize glutamine YP_002925866.1 similar to periplasmic-binding component of ABC transporters YP_002925867.1 binds DNA in a non-sequence-specific manner and is abundant during stationary phase; forms a DNA-protein crystal that protects DNA from damage; required for normal starvation response and long-term stationary viability; forms a homododecameric complex and sequesters iron which provides protection against oxidative damage YP_002925868.1 MG1655 equivalent: b0813 YP_002925869.1 OmpX; involved in cell adhesion; forms an eight-stranded antiparallel beta-barrel that protrudes from the cell surface; mutations in the gene increase cell-surface contact in fimbriated strains but decrease contact in nonfimbriated strains YP_002925870.1 MG1655 equivalent: b0815 YP_002925871.1 MG1655 equivalent: b0816 YP_002925872.1 Transcriptional regulator that represses the manganese transporter MntH when manganese is present YP_002925873.1 MG1655 equivalent: b0818 YP_002925874.1 MG1655 equivalent: b0819 YP_002925875.1 MG1655 equivalent: b0820 YP_002925876.1 MG1655 equivalent: b0821 YP_002925877.1 MG1655 equivalent: b0822 YP_002925878.1 MG1655 equivalent: b0823 YP_002925879.1 MG1655 equivalent: b0824 YP_002925880.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_002925881.1 ATP-dependent adenylate transferase, transfers adenyl moiety to the MoeD subunit of molybdopterin synthase YP_002925882.1 is involved in the formation of active molybdenum cofactor and the chelation of molybdenum YP_002925883.1 MG1655 equivalent: b0828 YP_002925884.1 with GsiBCD is involved in glutathione import; GsiA contains 2 ATP-binding domains YP_002925885.1 MG1655 equivalent: b0830 YP_002925886.1 MG1655 equivalent: b0831 YP_002925887.1 MG1655 equivalent: b0832 YP_002925888.1 MG1655 equivalent: b0833 YP_002925889.1 MG1655 equivalent: b0834 YP_002925890.1 catalyzes the methylthiolation of an aspartic acid residue of the S12 protein of the 30S ribosomal subunit YP_002925891.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_002925892.1 MG1655 equivalent: b0837 YP_002925893.1 MG1655 equivalent: b0838 YP_002925894.1 penicillin-binding protein 6a; removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_002925895.1 MG1655 equivalent: b0840 YP_002925896.1 MG1655 equivalent: b0841 YP_002925897.1 MG1655 equivalent: b0842 YP_002925898.1 MG1655 equivalent: b0843 YP_002925899.1 MG1655 equivalent: b0844 YP_002925900.1 MG1655 equivalent: b0845 YP_002925901.1 MG1655 equivalent: b0846 YP_002925902.1 MG1655 equivalent: b0847 YP_002925903.1 MG1655 equivalent: b0848 YP_002925904.1 functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase; also involved in reducing some disulfides in a coupled system with glutathione reductase YP_002925905.1 YbjC; located in the same operon as the nfsA gene; member of the soxRS regulon which mediates in part the increased levels of superoxide in response to oxidative stress; induced by paraquat; regulated by SoxS; unknown function YP_002925906.1 NADPH-dependent; oxygen-insensitive; catalyzes the reduction of nitroaromatic compounds YP_002925907.1 responsible for the addition of glutamate residues to the C-terminus of ribosomal protein S6 YP_002925908.1 MG1655 equivalent: b0853 YP_002925909.1 MG1655 equivalent: b0854 YP_002925910.1 part of the PotFGHI ATP-dependent putrescine transporter YP_002925911.1 MG1655 equivalent: b0856 YP_002925912.1 MG1655 equivalent: b0857 YP_002925913.1 MG1655 equivalent: b0858 YP_002925914.1 RNA uridine methyltransferase B; catalyzes the formation of 5-methyl-uridine at position 747 in 23S rRNA YP_002925915.1 MG1655 equivalent: b0860 YP_002925916.1 with ArtPQJI acts to transport arginine across the inner membrane YP_002925917.1 with ArtPMJI transports arginine across the inner membrane YP_002925918.1 MG1655 equivalent: b0863 YP_002925919.1 With ArtMQJI transports arginine across the inner membrane YP_002925920.1 induced during stationary phase and by acivicin (a glutamine analog); regulated by Lrp and RpoS YP_002925921.1 MG1655 equivalent: b0866 YP_002925922.1 MG1655 equivalent: b0867 YP_002925923.1 MG1655 equivalent: b0868 YP_002925924.1 MG1655 equivalent: b0869 YP_002925925.1 low- specificity; catalyzes the formation of acetaldehyde and glycine from L-threonine; acts on L-threonine, L-allo-threonine, L-threo-phenylserine, and L-erythro-phenylserine YP_002925926.1 catalyzes the formation of acetate from pyruvate YP_002925927.1 MG1655 equivalent: b0872 YP_002925928.1 catalyzes the reduction of hydroxylamine to ammonia and water YP_002925929.1 MG1655 equivalent: b0874 YP_002925930.1 porin involved in osmoregulation allowing water to move into and out of the cell in response to osmotic pressure YP_002925931.1 MG1655 equivalent: b0876 YP_002925932.1 MG1655 equivalent: b0877 YP_002925933.1 confers macrolide resistance via active drug efflux YP_002925934.1 with MacA is involved in the export of macrolide YP_002925935.1 inhibits DNA replication at both initiation and elongation steps; stationary phase and starvation inducible YP_002925936.1 involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation; binds to the N-terminal domain of the chaperone ClpA YP_002925937.1 ATPase and specificity subunit of the ClpA-ClpP ATP dependent serine protease; directs protease to specific substrates YP_002925938.1 stimulates the activities of the other two initiation factors, IF-2 and IF-3 YP_002925939.1 leucyltransferase; phenylalanyltransferse; functions in the N-end rule pathway; transfers Leu, Phe, Met, from aminoacyl-tRNAs to N-terminal of proteins with Arg or Lys YP_002925940.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_002925941.1 in Escherichia coli the CydCD ABC transporter exports cysteine and glutathione into the periplasm in order to maintain redox balance; important for cytochrome bd and c YP_002925942.1 catalyzes the transfer of electrons from NADPH to thioredoxin; FAD/NAD(P) binding YP_002925943.1 mediates a global response to leucine; acts as a regulator for several genes involved in the high-affinity branched-chain amino acid transport system YP_002925944.1 DNA-binding membrane protein required for chromosome resolution and partitioning YP_002925945.1 participates with LolB in the incorporation of lipoprotein into the outer membrane YP_002925946.1 MG1655 equivalent: b0892 YP_002925947.1 catalyzes a two-step reaction, first charging a serine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002925948.1 MG1655 equivalent: b0894 YP_002925949.1 MG1655 equivalent: b0895 YP_002925950.1 MG1655 equivalent: b0896 YP_002925951.1 MG1655 equivalent: b0897 YP_002925952.1 MG1655 equivalent: b0898 YP_002925953.1 MG1655 equivalent: b0899 YP_002925954.1 MG1655 equivalent: b0900 YP_002925955.1 MG1655 equivalent: b0901 YP_002925956.1 activates pyruvate formate-lyase 1 under anaerobic conditions YP_002925957.1 MG1655 equivalent: b0903 YP_002925958.1 MG1655 equivalent: b0904 YP_002925959.1 MG1655 equivalent: b0905 YP_002925960.1 MG1655 equivalent: b0906 YP_002925961.1 catalyzes the formation of 3-phosphonooxypyruvate and glutamate from O-phospho-L-serine and 2-oxoglutarate; required both in major phosphorylated pathway of serine biosynthesis and in the biosynthesis of pyridoxine YP_002925962.1 catalyzes the formation of 5-O-(1-carboxyvinyl)-3-phosphoshikimate from phosphoenolpyruvate and 3-phosphoshikimate in tryptophan biosynthesis YP_002925963.1 MG1655 equivalent: b0909 YP_002925964.1 Catalyzes the formation of (d)CDP from ATP and (d)CMP YP_002925965.1 in Escherichia coli this protein is involved in binding to the leader sequence of mRNAs and is itself bound to the 30S subunit; autoregulates expression via a C-terminal domain; in most gram negative organisms this protein is composed of 6 repeats of the S1 domain while in gram positive there are 4 repeats; the S1 nucleic acid-binding domain is found associated with other proteins YP_002925966.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_002925967.1 MG1655 equivalent: b0913 YP_002925968.1 involved in the transport of lipid A across the inner membrane YP_002925969.1 transfers the gamma-phosphate of ATP to the 4' position of a tetraacyldisaccharide 1-phosphate intermediate to form tetraacyldisaccharide 1,4'-bis-phosphate YP_002925970.1 MG1655 equivalent: b0916 YP_002925971.1 MG1655 equivalent: b0917 YP_002925972.1 CMP-2-keto-3-deoxyoctulosonic acid synthetase; catalyzes the formation of CMP-3-deoxy-D-manno-octulosonate from CTP and 3-deoxy-D-manno-octulosonate which is incorporated into LPS YP_002925973.1 MG1655 equivalent: b0919 YP_002925974.1 MG1655 equivalent: b0920 YP_002925975.1 involved in cellular zinc and cadmium homeostasis by binding excess metal ions to its cysteine sulfurs and histidine nitrogens; expression of smtA in cyanobacteria is repressed by SmtB at low concentrations of zinc; NO elicits release of Zn ions from SmtA YP_002925976.1 acts with MukB and MukE to condense the chromosome and allow for segregation during cell division YP_002925977.1 acts with MukB and MukF to condense the chromosome and allow for segregation during cell division YP_002925978.1 SMC (structural maintenance of chromosomes) family of proteins; involved in chromosome condensatin and partitioning; forms a homodimer and the C-terminal is essential for DNA-binding activity while the purified N-terminal domain binds FtsZ; mutations result in cell division defects YP_002925979.1 MG1655 equivalent: b0925 YP_002925980.1 MG1655 equivalent: b0926 YP_002925981.1 MG1655 equivalent: b0927 YP_002925982.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_002925983.1 outer membrane porin F; 1a; Ia; b YP_002925984.1 catalyzes a two-step reaction, first charging an asparagine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002925985.1 catalyzes the formation of nictonate and 5-phospho-alpha-D-ribose 1-diphosphate from nicotinate D-ribonucleotide and diphosphate YP_002925986.1 MG1655 equivalent: b0932 YP_002925987.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic substrate-binding subunit, SsuB the ATP-binding subunit and SsuC the permease YP_002925988.1 part of the ABC type transport system for alkanesulfonate SsuABC; SsuB the ATP-binding subunit and SsuC the permease YP_002925989.1 catalyzes the release of sulfite from alkanesulfonates YP_002925990.1 part of the ABC type transport system SsuABC for aliphatic sulfonates; with SsuA being the periplasmic subunit SsuB the ATP-binding subunit and SsuC the permease YP_002925991.1 MG1655 equivalent: b0937 YP_002925992.1 MG1655 equivalent: b0938 YP_002925993.1 MG1655 equivalent: b0939 YP_002925994.1 MG1655 equivalent: b0940 YP_002925995.1 MG1655 equivalent: b0941 YP_002925996.1 MG1655 equivalent: b0942 YP_002925997.1 MG1655 equivalent: b0943 YP_002925998.1 MG1655 equivalent: b0944 YP_002925999.1 catalyzes the conversion of dihydroorotate to orotate in the pyrimidine biosynthesis pathway; uses a flavin nucleotide as an essential cofactor; class 2 enzymes are monomeric and compared to the class 1 class 2 possess an extended N terminus, which plays a role in the membrane association of the enzyme and provides the binding site for the respiratory quinones that serve as physiological electron acceptors YP_002926000.1 MG1655 equivalent: b0946 YP_002926001.1 MG1655 equivalent: b0947 YP_002926002.1 catalyzes the N2-methyl guanosine modification of the G2445 residue of 23S rRNA YP_002926003.1 Uup; in Escherichia coli this cytoplasmic protein was shown to contain ATPase activity; mutations in this gene affect RecA-independent excision of transposons and affects Mu bacteriophage growth YP_002926004.1 MG1655 equivalent: b0950 YP_002926005.1 MG1655 equivalent: b0951 YP_002926006.1 MG1655 equivalent: b0952 YP_002926007.1 MG1655 equivalent: b0953 YP_002926008.1 catalyzes the dehydration of (3R)-3-hydroxydecanoyl-ACP to 2,3-decenoyl-ACP or 3,4-decenoyl-ACP YP_002926009.1 MG1655 equivalent: b0955 YP_002926010.1 MG1655 equivalent: b0956 YP_002926011.1 OmpA is believed to be a porin, involved in diffusion of nonspecific small solutes across the outer membrane. It is the most abundant integral protein of the outer membrane of E. coli, and it is known to play a role as a phage receptor, a mediator of F-factor dependent conjugation, and in maintaining the structural shape of the outer membrane; 3a; II*; G; d YP_002926012.1 MG1655 equivalent: b0958 YP_002926013.1 MG1655 equivalent: b0959 YP_002926014.1 MG1655 equivalent: b0960 YP_002926015.1 MG1655 equivalent: b0961 YP_002926016.1 catalyzes the ATP-dependent unwinding of duplex DNA in the 3' to 5' direction with respect to the bound single strand YP_002926017.1 catalyzes the formation of methylglyoxal from glycerone phosphate YP_002926018.1 MG1655 equivalent: b0964 YP_002926019.1 MG1655 equivalent: b0965 YP_002926020.1 MG1655 equivalent: b0966 YP_002926021.1 MG1655 equivalent: b0967 YP_002926022.1 catalyzes the hydrolysis of acylphosphate YP_002926023.1 transfers sulfur from TusBCD complex to MnmA; involved in thiouridation of U34 position of some tRNAs YP_002926024.1 MG1655 equivalent: b0970 YP_002926025.1 MG1655 equivalent: b0972 YP_002926026.1 involved in hydrogen cycling during fermentative growth YP_002926027.1 MG1655 equivalent: b0974 YP_002926028.1 HyaD; endopeptidase involved in the cleavage of the C-terminus end of HyaB (the large subunit of hydrogenase 1) YP_002926029.1 involved in processing hydrogenase proteins HyaA and HyaB YP_002926030.1 MG1655 equivalent: b0977 YP_002926031.1 MG1655 equivalent: b0978 YP_002926032.1 MG1655 equivalent: b0979 YP_002926033.1 expressed during stationary phase YP_002926034.1 MG1655 equivalent: b0980 YP_002926035.1 MG1655 equivalent: b0981 YP_002926036.1 Etk and Etp are a tyrosine kinase-tyrosine phosphatase pair, etp dephosphorylates etk YP_002926037.1 MG1655 equivalent: b0983 YP_002926038.1 MG1655 equivalent: b0984 YP_002926039.1 MG1655 equivalent: b0985 YP_002926040.1 MG1655 equivalent: b0986 YP_002926041.1 MG1655 equivalent: b0987 YP_002926042.1 MG1655 equivalent: b4516 YP_002926043.1 MG1655 equivalent: b0988 YP_002926044.1 MG1655 equivalent: b0989 YP_002926045.1 MG1655 equivalent: b0990 YP_002926046.1 MG1655 equivalent: b0991 YP_002926047.1 MG1655 equivalent: b4517 YP_002926048.1 MG1655 equivalent: b0992 YP_002926049.1 Member of the two-component regulatory system torS/torR involved in the anaerobic utilization of trimethylamine-N-oxide YP_002926050.1 periplasmic sensory protein associated with the TorRS two-component regulatory system YP_002926051.1 response regulator in two-component regulatory system with TorS; involved in regulation of trimethylamine N-oxide reductase genes YP_002926052.1 MG1655 equivalent: b0996 YP_002926053.1 MG1655 equivalent: b0997 YP_002926054.1 TorD; involved in the biogenesis of torA; acts on torA before the insertion of the molybdenum cofactor and, as a result, probably favors a conformation of the apoenzyme that is competent for acquiring the cofactor YP_002926055.1 with CpbA modulates the activity of the dnaK chaperone system; interacts with CbpA and inhibits both the DnaJ-like co-chaperone activity and the DNA binding activity of CbpA YP_002926056.1 functions as a co-chaperone of DnaK; functional analog of DnaJ; co-chaperone with DnaK, molecular chaperone in an adaptive response to environmental stresses other than heat shock YP_002926057.1 MG1655 equivalent: b1001 YP_002926058.1 MG1655 equivalent: b1002 YP_002926059.1 MG1655 equivalent: b1003 YP_002926060.1 stationary phase protein that binds TrpR repressor YP_002926061.1 MG1655 equivalent: b4518 YP_002926062.1 MG1655 equivalent: b1006 YP_002926063.1 MG1655 equivalent: b1007 YP_002926064.1 MG1655 equivalent: b1008 YP_002926065.1 MG1655 equivalent: b1009 YP_002926066.1 MG1655 equivalent: b1010 YP_002926067.1 MG1655 equivalent: b1011 YP_002926068.1 MG1655 equivalent: b1012 YP_002926069.1 MG1655 equivalent: b1013 YP_002926070.1 proline utilization protein A; multifunctional protein that functions in proline catabolism in the first two enzymatic steps resulting in the conversion of proline to glutamate; in Escherichai coli this protein also self-regulates transcription via a DNA-binding domain at the N-terminus; forms dimers and is a peripherally membrane-associated protein YP_002926071.1 MG1655 equivalent: b1015 YP_002926072.1 MG1655 equivalent: b1018 YP_002926073.1 MG1655 equivalent: b1019 YP_002926074.1 MG1655 equivalent: b1020 YP_002926075.1 in Yersinia this gene is involved in biofilm formation and hemin adsorption; in Escherichia coli it is involved in PGA biosynthesis and export YP_002926076.1 predicted polysaccharide polymerase involved in biofilm formation; required for the synthesis of the beta-1,6-N-acetylglucosamine polysaccharide; PgaC; in Yersinia the HmsR protein is an inner membrane protein YP_002926077.1 in Yersinia this protein is involved in biofilm formation and hemin adsorption; related protein PgaB in Escherichia coli is an outer membrane N-deacetylase involved in poly-beta-1,6-N-acetyl-D-glucosamine (PGA) export YP_002926078.1 outer membrane protein essential for the synthesis of poly-beta-1,6-N-acetyl-D-glucosamine (PGA); adhesin required for biofilm formation; PgaA (HmsH) seems to translocate and/or dock PGA to the cell surface; member of the hmsHFRS (ycdSRQP or pgaABCD in Escherichia coli) operon in Yersinia YP_002926080.1 MG1655 equivalent: b1025 YP_002926081.1 MG1655 equivalent: b1026 YP_002926082.1 MG1655 equivalent: b1027 YP_002926083.1 MG1655 equivalent: b1029 YP_002926084.1 MG1655 equivalent: b1033 YP_002926085.1 MG1655 equivalent: b1034 YP_002926086.1 MG1655 equivalent: b1035 YP_002926087.1 MG1655 equivalent: b1036 YP_002926088.1 MG1655 equivalent: b1037 YP_002926089.1 nucleator protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_002926090.1 chaperone-like protein that participates in the polymerization of curlin (CsgA) subunits into curli (extracellular fibers from Escherichia and Salmonella spp. that are involved in the colonization of inert surfaces and biofilm formation); part of the curli secretion and assembly protein complex YP_002926091.1 activates the csgBA and csgDEFG operons involved in biofilm formation YP_002926092.1 CsgB; functions as a nucleator in the assembly of curli (coiled surface structures) on the cell surface YP_002926093.1 MG1655 equivalent: b1042 YP_002926094.1 involved in autoagglutination of curliated cells; not involved in production of curli fibers YP_002926095.1 MG1655 equivalent: b1044 YP_002926096.1 MG1655 equivalent: b1045 YP_002926097.1 MG1655 equivalent: b1046 YP_002926098.1 required for the transfer of succinyl residues to the glucan backbone YP_002926099.1 involved in the biosynthesis of osmoregulated periplasmic glucans; required for the assembly of the polyglucose structure of glucan YP_002926100.1 necessary for biosynthesis of osmoregulated periplasmic glucans possibly involved in the transfer to the periplasmic space YP_002926101.1 MG1655 equivalent: b1050 YP_002926102.1 MG1655 equivalent: b1051 YP_002926103.1 Confers resistance to fosfomycin and deoxycholate YP_002926104.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(lauroyl)-lipid IVA YP_002926105.1 MG1655 equivalent: b1055 YP_002926106.1 MG1655 equivalent: b1056 YP_002926107.1 MG1655 equivalent: b1057 YP_002926108.1 MG1655 equivalent: b1058 YP_002926109.1 catalyzes the demethylation of N-methyl-L-tryptophan forming L-tryptophan and formaldehyde; FAD-binding; can also catalyze the demethylation of other N-methyl amino acids YP_002926110.1 BssS; regulator of biofilm through signal secretion; disruption of this gene in Escherichia coli led to effects on biofilm formation, alteration in expression of a number of genes and mutations in bssS led to defects in indole transport and autoinducer-2 uptake and processing YP_002926111.1 MG1655 equivalent: b1061 YP_002926112.1 catalyzes the formation of N-carbamoyl-L-aspartate from (S)-dihydroorotate in pyrimidine biosynthesis YP_002926113.1 MG1655 equivalent: b1063 YP_002926114.1 cofactor involved in the reduction of disulfides YP_002926115.1 Confers resistance to norfloxacin and enoxacin YP_002926116.1 MG1655 equivalent: b1066 YP_002926117.1 MG1655 equivalent: b1067 YP_002926118.1 MG1655 equivalent: b1068 YP_002926119.1 MG1655 equivalent: b1069 YP_002926120.1 MG1655 equivalent: b1070 YP_002926121.1 regulates the flagellar specific sigma28 transcription factor YP_002926122.1 required for the assembly of the flagellar basal body P-ring YP_002926123.1 with FlgF and C makes up the proximal portion of the flagellar basal body rod; Vibrio parahaemolyticus protein is associated with the polar flagella YP_002926124.1 with FlgF and B makes up the proximal portion of the flagellar basal body rod YP_002926125.1 acts as a scaffold for the assembly of hook proteins onto the flagellar basal body rod; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of some flagellar genes; in V. parahaemolyticus one set used for lateral flagella production and the other is used for the polar flagella production YP_002926126.1 the hook connects flagellar basal body to the flagellar filament YP_002926127.1 FlgF, with FlgB and C, makes up the proximal portion of the flagellar basal body rod YP_002926128.1 makes up the distal portion of the flagellar basal body rod YP_002926129.1 part of the flagellar basal body which consists of four rings L,P, S and M mounted on a central rod YP_002926130.1 part of the basal body which consists of four rings L, P, S, and M mounted on a central rod; Vibrio parahaemolyticus, Yersinia, Bradyrhizobium and other bacteria have two copies of this and other flagellar genes; the V. parahaemolyticus protein is associated with the polar flagella and the Bradyrhizobium protein is associated with the thick flagellum YP_002926131.1 Flagellum-specific muramidase which hydrolyzes the peptidoglycan layer to assemble the rod structure in the periplasmic space YP_002926132.1 with FlgL acts as a hook filament junction protein to join the flagellar filament to the hook YP_002926133.1 with FlgK acts as a hook filament junction protein to join the flagellar filament to the hook; Yersinia, Vibrio parahaemolyticus, Bradyrhizobium and other organisms have 2 copies of this and other flagellar genes YP_002926134.1 bifunctional ribonuclease E/endoribonuclease/RNA-binding protein/RNA degradosome binding protein; forms part of the membrane-associated degradosome complex along with PNPase, RhlB, and enolase YP_002926135.1 MG1655 equivalent: b1085 YP_002926136.1 catalyzes the transformation of uracil to pseudouracil at nucleotides U955, U2504, and U2580 in 23S rRNA YP_002926137.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_002926138.1 MG1655 equivalent: b1088 YP_002926139.1 some L32 proteins have zinc finger motifs consisting of CXXC while others do not YP_002926140.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsY YP_002926141.1 FabH; beta-ketoacyl-acyl carrier protein synthase III; catalyzes the condensation of acetyl-CoA with malonyl-ACP to initiate cycles of fatty acid elongation; differs from 3-oxoacyl-(acyl carrier protein) synthase I and II in that it utilizes CoA thioesters as primers rather than acyl-ACPs YP_002926142.1 MG1655 equivalent: b1092 YP_002926143.1 catalyzes the first of the two reduction steps in the elongation cycle of fatty acid synthesis YP_002926144.1 carries the fatty acid chain in fatty acid biosynthesis YP_002926145.1 FabF; beta-ketoacyl-ACP synthase II, KASII; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002926146.1 catalyzes the formation of 4-aminobenzoate and pyruvate from 4-amino-4-deoxychorismate YP_002926147.1 MG1655 equivalent: b1097 YP_002926148.1 catalyzes the reversible phosphoryl transfer from adenosine triphosphate (ATP) to thymidine monophosphate (dTMP) to form thymidine diphosphate (dTDP) YP_002926149.1 catalyzes the DNA-template-directed extension of the 3'-end of a DNA strand; the delta' subunit seems to interact with the gamma subunit to transfer the beta subunit on the DNA YP_002926150.1 MG1655 equivalent: b1100 YP_002926151.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002926152.1 MG1655 equivalent: b1102 YP_002926153.1 MG1655 equivalent: b1103 YP_002926154.1 MG1655 equivalent: b1104 YP_002926155.1 MG1655 equivalent: b1105 YP_002926156.1 catalyzes the phosphorylation of thiamine to thiamine phosphate YP_002926157.1 hydrolyzes the terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides YP_002926158.1 MG1655 equivalent: b1108 YP_002926159.1 MG1655 equivalent: b1109 YP_002926160.1 MG1655 equivalent: b1110 YP_002926161.1 MG1655 equivalent: b1111 YP_002926162.1 MG1655 equivalent: b1112 YP_002926163.1 MG1655 equivalent: b1113 YP_002926164.1 MG1655 equivalent: b1114 YP_002926165.1 MG1655 equivalent: b1115 YP_002926166.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_002926167.1 outer membrane specific; part of transporter complex lolCDE involved in the translocation of mature outer membrane-directed lipoproteins, from the inner membrane to the periplasmic chaperone YP_002926168.1 part of the ATP-dependent transport system LolCDE; responsible for the localization of lipoproteins to the periplasmic surface of the outer membrane YP_002926169.1 catalyzes the formation of N-acetyl-D-glucosamine-6-phosphate from N-acetyl-D-glucosamine YP_002926170.1 Modulates the activities of several enzymes which are inactive in their acetylated form YP_002926171.1 MG1655 equivalent: b1121 YP_002926172.1 MG1655 equivalent: b1122 YP_002926173.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotD is a periplasmic component that binds the substrate YP_002926174.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotC is a membrane component YP_002926175.1 can transport spermidine and putrescine but affinity is higher for spermidine; forms a complex of PotA2BCD; PotB is a membrane component YP_002926176.1 functions together with PotBCD (A2BCD) in ATP-dependent polyamine transport; PotA is the membrane-associated ATPase YP_002926177.1 catalyzes the release of the N-terminal amino acid from a tripeptide YP_002926178.1 MG1655 equivalent: b1128 YP_002926179.1 MG1655 equivalent: b1129 YP_002926180.1 response regulator in two-component regulatory system with PhoQ; involved in magnesium starvation and stress YP_002926181.1 Catalyzes two discrete reactions in the de novo synthesis of purines: the cleavage of adenylosuccinate and succinylaminoimidazole carboxamide ribotide YP_002926182.1 HflD; UPF0274; in Escherichia coli this protein is peripherally associated with the membrane and appears to act with lambda CII protein; in Haemophilus influenzae a knockout of the HI0638 gene affected paracytosis YP_002926183.1 catalyzes a sulfuration reaction to synthesize 2-thiouridine at the U34 position of tRNAs YP_002926184.1 MG1655 equivalent: b1134 YP_002926185.1 catalyzes the formation of pseudouridine from uracil-2457 in 23S ribosomal RNA YP_002926186.1 Converts isocitrate to alpha ketoglutarate YP_002926187.1 MG1655 equivalent: b1160 YP_002926188.1 MG1655 equivalent: b1161 YP_002926189.1 MG1655 equivalent: b1162 YP_002926190.1 MG1655 equivalent: b1163 YP_002926191.1 MG1655 equivalent: b1164 YP_002926192.1 MG1655 equivalent: b1165 YP_002926193.1 MG1655 equivalent: b1166 YP_002926194.1 MG1655 equivalent: b1167 YP_002926195.1 MG1655 equivalent: b1168 YP_002926196.1 MG1655 equivalent: b4520 YP_002926197.1 MG1655 equivalent: b1171 YP_002926198.1 MG1655 equivalent: b1172 YP_002926199.1 MG1655 equivalent: b4593 YP_002926200.1 MG1655 equivalent: b4594 YP_002926201.1 works in conjunction with MinC and MinD to enable cell division at the midpoint of the long axis of the cell YP_002926202.1 ATPase; with MinC inhibits cell division by blocking formation of the polar Z ring septums YP_002926203.1 blocks the formation of polar Z-ring septums YP_002926204.1 MG1655 equivalent: b1177 YP_002926205.1 MG1655 equivalent: b1178 YP_002926206.1 MG1655 equivalent: b1179 YP_002926207.1 MG1655 equivalent: b1180 YP_002926208.1 MG1655 equivalent: b1181 YP_002926209.1 Acts by forming a pore-like structure upon contact with mammalian cells YP_002926210.1 binds with UmuC protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_002926211.1 binds processed UmuD protein to form functional DNA pol V (UmuD'2UmuC); involved in translesion polymerization YP_002926212.1 disulfide oxidoreductase; integral membrane protein; required for perioplasmic disulfide bond formation; oxidizes DsbA protein YP_002926213.1 involved in regulation of intracellular pH under alkaline conditions YP_002926214.1 Multifunctional regulator of fatty acid metabolism YP_002926215.1 MG1655 equivalent: b1188 YP_002926216.1 catalyzes the oxidative deamination of D-amino acids YP_002926217.1 catabolic enzyme, converts L-alanine to D-alanine which is then oxidized to pyruvate by dadA YP_002926218.1 the Vibrio parahaemolyticus gene VP2867 was found to be a potassium/proton antiporter; can rapidly extrude potassium against a potassium gradient at alkaline pH when cloned and expressed in Escherichia coli YP_002926219.1 catalyzes the release of D-alanine from L-alanyl-D-glutamyl-meso-diaminopimelyl-D-alanine YP_002926220.1 MG1655 equivalent: b1193 YP_002926221.1 MG1655 equivalent: b1194 YP_002926222.1 MG1655 equivalent: b1195 YP_002926223.1 MG1655 equivalent: b1196 YP_002926224.1 periplasmic; catalyzes the hydrolysis of trehalose to glucose which can then be imported into the cell YP_002926225.1 phosphotransferaese subunit; phosphorylates dihydroxyacetone along with DhaK/DhaL YP_002926226.1 with DhaK and DhaM catalyzes the phosphorylation of dihydroxyacetone YP_002926227.1 with DhaL and DhaM forms dihydroxyacetone kinase, which is responsible for phosphorylating dihydroxyacetone; DhaK is the dihydroxyacetone binding subunit of the dihydroxyacetone kinase YP_002926228.1 Positively regulates the dhaKLM operon from a sigma-70 promoter YP_002926229.1 MG1655 equivalent: b1202 YP_002926230.1 translation-associated GTPase; the crystal structure of the Haemophilus influenzae YchF protein showed similarity to the yeast structure (PDB: 1NI3); fluorescence spectroscopy revealed nucleic acid binding; the yeast protein YBR025c interacts with the translation elongation factor eEF1 YP_002926231.1 Enables the recycling of peptidyl-tRNAs produced at termination of translation YP_002926232.1 YchH; transcription activated by CRP (cyclic AMP receptor protein), a global transcription factor involved in regulation of metabolism in enteric bacteria; ychH presents a class II promoter to bind CRP; unknown function YP_002926233.1 putative role in sulfate transport across the inner membrane; member of the SulP family of sulfate transporters; seems to mediate transport via sulfate/proton symport YP_002926234.1 catalyzes the formation of 5-phospho-alpha-D-ribose 1-phosphate from D-ribose 5-phosphate and ATP YP_002926235.1 An essential enzyme in the nonmevalonate pathway of isopentenyl diphosphate and dimethylallyl diphosphate biosynthesis YP_002926236.1 Incorporates lipoproteins in the outer membrane after they are released by the LolA protein YP_002926237.1 catalyzes the formation of glutamate-1-semialdehyde from glutamyl-tRNA(Glu) and NADPH; the second step of the pathway is catalyzed by glutamate-1-semialdehyde aminomutase which results in the formation of 5-aminolevulinic acid; functions in porphyrin (tetrapyrroles) biosynthesis; the crystal structure showed a C-terminal dimerization domain that appears to be absent in Chlamydial proteins YP_002926238.1 recognizes the termination signals UAG and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF1; this protein is similar to release factor 2 YP_002926239.1 HemK; PrmC; transfers a methyl group from S-adenosylmethionine to amide nitrogen of specific glutamine residues in protein chain release factors PrfA and PrfB YP_002926240.1 MG1655 equivalent: b1213 YP_002926241.1 MG1655 equivalent: b1214 YP_002926242.1 catalyzes the formation of 2-dehydro-3-deoxy-D-octonate 8-phosphate from phosphoenolpyruvate and D-arabinose 5-phosphate in LPS biosynthesis YP_002926243.1 MG1655 equivalent: b4419 YP_002926244.1 MG1655 equivalent: b4421 YP_002926245.1 MG1655 equivalent: b4423 YP_002926246.1 MG1655 equivalent: b1216 YP_002926247.1 in Escherichia coli this protein putatively regulates the sodium/proton (also pH-independent calcium/proton) antiporter chaA; has weak affinity for calcium and magnesium ions YP_002926248.1 MG1655 equivalent: b1218 YP_002926249.1 MG1655 equivalent: b1219 YP_002926250.1 MG1655 equivalent: b1220 YP_002926251.1 two-component response regulator NarL; phosphorylated by NarQ; activates transcription of nitrate and nitrite reductase genes and represses transcription of fumarate reductase YP_002926252.1 MG1655 equivalent: b1222 YP_002926253.1 MG1655 equivalent: b1223 YP_002926254.1 MG1655 equivalent: b1224 YP_002926255.1 MG1655 equivalent: b1225 YP_002926256.1 MG1655 equivalent: b1226 YP_002926257.1 MG1655 equivalent: b1227 YP_002926258.1 MG1655 equivalent: b1228 YP_002926259.1 MG1655 equivalent: b1229 YP_002926260.1 produces formate from formyl-tetrahydrofolate which is the major source of formate for PurT in de novo purine nucleotide biosynthesis; has a role in one-carbon metabolism; forms a homohexamer; activated by methionine and inhibited by glycine YP_002926261.1 MG1655 equivalent: b1233 YP_002926262.1 MG1655 equivalent: b1234 YP_002926264.1 MG1655 equivalent: b1235 YP_002926265.1 together with GalF subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_002926266.1 MG1655 equivalent: b1237 YP_002926267.1 catalyzes the formation of thymidine 5'-phosphate from thymidine YP_002926268.1 MG1655 equivalent: b1241 YP_002926269.1 MG1655 equivalent: b1242 YP_002926270.1 MG1655 equivalent: b1243 YP_002926271.1 COG0428 YP_002926273.1 MG1655 equivalent: b1245 YP_002926274.1 MG1655 equivalent: b1246 YP_002926275.1 MG1655 equivalent: b1247 YP_002926276.1 highly acidic protein; the structure of the Haemophilus influenzae protein shows similarity to uracil DNA glycosylase inhibitor (Ugi); binds heat-unstable protein (HU-alpha) which is a histone-like protein YP_002926277.1 catalyzes the transfer of a phosphatidyl group to phosphodidylglycerol to form cardiolipin (diphosphatidylglycerol) YP_002926278.1 MG1655 equivalent: b4595 YP_002926279.1 MG1655 equivalent: b1250 YP_002926280.1 unknown function; YciI from Haemophilus influenzae presents crystal structure similarity to a muconolactone isomerase, but does not seem to catalyze any of the predicted reactions based on sequence and structure similarity YP_002926281.1 membrane spanning protein in TonB-ExbB-ExbD complex; transduces proton motive force of the cytoplasmic membrane to outer membrane transporters; involved in the transport of ron-siderophore complexes, vitamin B12 and colicins YP_002926282.1 YciA; hydrolase that catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA and malonyl-CoA; member of the the acyl coenzyme A hydrolase family of proteins YP_002926283.1 Involved in cell division; probably involved in intracellular septation YP_002926284.1 MG1655 equivalent: b1255 YP_002926285.1 receptor for colicin S4 YP_002926286.1 MG1655 equivalent: b1257 YP_002926287.1 MG1655 equivalent: b1258 YP_002926288.1 MG1655 equivalent: b1259 YP_002926289.1 catalyzes the formation of indole and glyceraldehyde 3-phosphate from indoleglycerol phosphate in tryptophan biosynthesis YP_002926290.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_002926291.1 monomeric bifunctional protein; functions in tryptophan biosynthesis pathway; phosphoribosylanthranilate is rearranged to carboxyphenylaminodeoxyribulosephosphate which is then closed to form indole-3-glycerol phosphate YP_002926292.1 bifunctional anthranilate synthase II/anthranilate phosphoribosyltransferase; TrpD; forms a heterotetramer with Trp E and the complex catalyzes the formation of anthranilate from chorismate and glutamine; also catalyzes the formation of N-(5-phospho-D-ribosyl)-anthranilate from athranilate and 5-phospho-alpha-D-ribose 1-diphosphate; functions in tryptophan biosynthesis YP_002926293.1 with component II, the glutamine amidotransferase, catalyzes the formation of anthranilate from chorismate and glutamine YP_002926295.1 MG1655 equivalent: b1266 YP_002926296.1 MG1655 equivalent: b1267 YP_002926297.1 MG1655 equivalent: b1268 YP_002926298.1 catalyzes the synthesis of pseudouridine from uracil-2605 in 23S ribosomal RNA YP_002926299.1 catalyzes the formation of adenosylcob(III)yrinic acid a,c-diamide from cob(I)yrinic acid a,c-diamide YP_002926300.1 MG1655 equivalent: b1271 YP_002926301.1 SohB; periplasmic protein; member of the peptidase S49 family YP_002926302.1 MG1655 equivalent: b1273 YP_002926303.1 catalyzes the ATP-dependent breakage of single-stranded DNA followed by passage and rejoining, maintains net negative superhelicity YP_002926304.1 LysR-type transcriptional regulator; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates cysteine biosynthesis by controlling expression of the cys regulon; autoregulates expression; crystal structure of Klebsiella aerogenes showed tetramer formation YP_002926305.1 MG1655 equivalent: b4522 YP_002926306.1 MG1655 equivalent: b4523 YP_002926307.1 Catalyzes the conversion of citrate to isocitrate YP_002926308.1 catalyzes the conversion of GTP to formate and 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine and diphosphate YP_002926309.1 MG1655 equivalent: b1278 YP_002926310.1 MG1655 equivalent: b1279 YP_002926311.1 MG1655 equivalent: b1280 YP_002926312.1 type 1 subfamily; involved in last step of pyrimidine biosynthesis; converts orotidine 5'-phosphate to UMP and carbon dioxide; OMP decarboxylase; OMPDCase; OMPdecase YP_002926313.1 involved in start site selection during the initiation of translation YP_002926314.1 MG1655 equivalent: b1283 YP_002926315.1 MG1655 equivalent: b1284 YP_002926316.1 MG1655 equivalent: b4596 YP_002926317.1 c-di-GMP phosphodiesterase; probably degrades signalling molecule c-di-GMP YP_002926318.1 Involved in mRNA degradation. Hydrolyzes single-stranded polyribonucleotides processively in the 3' to 5' direction YP_002926319.1 MG1655 equivalent: b1287 YP_002926320.1 Catalyzes a key regulatory step in fatty acid biosynthesis YP_002926321.1 MG1655 equivalent: b1289 YP_002926322.1 MG1655 equivalent: b1290 YP_002926323.1 MG1655 equivalent: b1291 YP_002926324.1 MG1655 equivalent: b1292 YP_002926325.1 MG1655 equivalent: b1293 YP_002926326.1 MG1655 equivalent: b1294 YP_002926327.1 MG1655 equivalent: b1295 YP_002926328.1 MG1655 equivalent: b1296 YP_002926329.1 MG1655 equivalent: b1297 YP_002926330.1 catalyzes the degradation of gamma-glutamyl-gamma-aminobutyrate into glutamate and gamma-aminobutyrate YP_002926331.1 regulates genes involved in putrescine degradation YP_002926332.1 catalyzes the formation of gamma-glutamyl-gamma-aminobutyrate from Gamma-glutamyl-gamma-aminobutyraldehyde; involved in putrescine degradation YP_002926333.1 MG1655 equivalent: b1301 YP_002926334.1 putrescine-inducible GABA aminotransferase; catalyzes the formation of glutamate and succinate semialdehyde from 4-aminobutyrate and 2-oxoglutarate YP_002926335.1 transcriptional activator for pspABCE which are induced in response to phage proteins, membrane altering stresses, and impaired proton expor YP_002926336.1 involved in maintaining membrane potential under membrane stress conditions; also acts as a negative transcriptional regulator of the phage shock protein (psp) operon(pspABCDE) by regulating the transcriptional activator PspF YP_002926337.1 acts together with PspC to induce psp operon during infection with phage, exposure to ethanol or osmotic shock; forms a complex with PspA and C; PspC is required for PspAB binding YP_002926338.1 with PsbB forms toxin/antitoxin pair; activates the psp operon in response to phage infection, exposure to ethanol or osmotic shock YP_002926339.1 MG1655 equivalent: b1307 YP_002926340.1 rhodanese; catalyzes the formation of thiocyanate from thiosulfate and hydrogen cyanide YP_002926341.1 MG1655 equivalent: b1309 YP_002926342.1 MG1655 equivalent: b1310 YP_002926343.1 MG1655 equivalent: b1311 YP_002926344.1 MG1655 equivalent: b1312 YP_002926345.1 MG1655 equivalent: b1313 YP_002926346.1 MG1655 equivalent: b1314 YP_002926347.1 MG1655 equivalent: b1315 YP_002926348.1 MG1655 equivalent: b1316 YP_002926349.1 MG1655 equivalent: b1317 YP_002926350.1 MG1655 equivalent: b1319 YP_002926351.1 MG1655 equivalent: b1320 YP_002926352.1 MG1655 equivalent: b1321 YP_002926353.1 MG1655 equivalent: b1322 YP_002926354.1 regulates genes involved in the biosynthesis and transport of aromatic amino acids YP_002926355.1 antioxidant activity; thioredoxin-dependent thiol peroxidase; forms homodimers in solution; shows substrate specificity to alkyl hydroperoxides; periplasmic protein YP_002926356.1 MG1655 equivalent: b1325 YP_002926357.1 MG1655 equivalent: b1326 YP_002926358.1 MG1655 equivalent: b1327 YP_002926359.1 MG1655 equivalent: b1328 YP_002926360.1 MG1655 equivalent: b1329 YP_002926361.1 MG1655 equivalent: b1330 YP_002926362.1 MG1655 equivalent: b1331 YP_002926363.1 MG1655 equivalent: b1332 YP_002926364.1 with UspC and UspD is involved in resistance to UV irradiation YP_002926365.1 Global transcription factor that controls the expression of over 100 target genes in response to anoxia YP_002926366.1 MG1655 equivalent: b1335 YP_002926367.1 MG1655 equivalent: b1336 YP_002926368.1 MG1655 equivalent: b1337 YP_002926369.1 MG1655 equivalent: b1338 YP_002926370.1 MG1655 equivalent: b1339 YP_002926371.1 MG1655 equivalent: b1340 YP_002926372.1 MG1655 equivalent: b1341 YP_002926373.1 MG1655 equivalent: b1342 YP_002926374.1 exhibits an RNA-dependent ATPase activity, specifically stimulated by bacterial 23S rRNA YP_002926375.1 TtcA; YdaO; catalyzes the thiolation of cytosine 32 in specific tRNAs YP_002926376.1 MG1655 equivalent: b1345 YP_002926377.1 MG1655 equivalent: b1346 YP_002926378.1 Rac prophage YP_002926379.1 seems to be involved in restriction alleviation and enhancement of modification by EcoKI, but not in restriction alleviation of type III restriction systems; Rac prophage YP_002926380.1 MG1655 equivalent: b1349 YP_002926381.1 The RecE (also known as exonuclease VIII) pathway is an alternative pathway for the initiation of homologous recombination in Escherichia coli. The RecE pathway is activated in recB, recC sbcA (suppressors of recB and recC) mutants. Activation of the RecE pathway results in the production of at least two phage proteins relevant for recombinational repair. RecE is a duplex DNA-specific exonuclease which produces 3' overhangs in duplex DNA by preferentially degrading the 5'-ending strands. Recombinational repair of E.coli chromosomal DNA involves as well other proteins: RecA, RecF, RecJ, RecO, RecR, and RuvC. YP_002926382.1 Rac prophage hypothetical protein YP_002926383.1 MG1655 equivalent: b4526 YP_002926384.1 Rac prophage Kil protein; Kil overexpression leads to morphological defects and inhibits cell division YP_002926385.1 MG1655 equivalent: b1353 YP_002926386.1 MG1655 equivalent: b4527 YP_002926387.1 MG1655 equivalent: b1355 YP_002926388.1 MG1655 equivalent: b1356 YP_002926389.1 MG1655 equivalent: b1357 YP_002926390.1 MG1655 equivalent: b1358 YP_002926391.1 MG1655 equivalent: b1359 YP_002926392.1 MG1655 equivalent: b1360 YP_002926393.1 MG1655 equivalent: b4528 YP_002926394.1 MG1655 equivalent: b1363 YP_002926395.1 MG1655 equivalent: b1365 YP_002926396.1 MG1655 equivalent: b1370 YP_002926397.1 MG1655 equivalent: b1372 YP_002926398.1 MG1655 equivalent: b1373 YP_002926399.1 MG1655 equivalent: b1374 YP_002926400.1 MG1655 equivalent: b1375 YP_002926401.1 MG1655 equivalent: b1376 YP_002926402.1 MG1655 equivalent: b1377 YP_002926403.1 MG1655 equivalent: b1378 YP_002926404.1 MG1655 equivalent: b4529 YP_002926405.1 MG1655 equivalent: b1379 YP_002926406.1 MG1655 equivalent: b1380 YP_002926407.1 MG1655 equivalent: b1381 YP_002926408.1 MG1655 equivalent: b1382 YP_002926409.1 MG1655 equivalent: b1383 YP_002926410.1 activator of genes involved in phenylacetic acid catabolism YP_002926411.1 MG1655 equivalent: b1385 YP_002926412.1 catalyzes the formation of phenylacetaldehyde from 2-phenylethylamine YP_002926413.1 catalyzes the ring cleavage reaction in phenylacetate degradation and the formation of 3-hydroxyacyl-CoA from crotonyl-CoA YP_002926414.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA YP_002926415.1 with PaaBCDE catalyzes the hydroxylation of phenylacetyl-CoA; involved in phenylacetate degradation YP_002926416.1 MG1655 equivalent: b1390 YP_002926417.1 MG1655 equivalent: b1391 YP_002926418.1 MG1655 equivalent: b1392 YP_002926419.1 MG1655 equivalent: b1393 YP_002926420.1 Catalyzes the reversible hydration of unsaturated fatty acyl-CoA to beta-hydroxyacyl-CoA YP_002926421.1 converts 3-hydroxyadipyl-CoA to beta-ketoadipyl-CoA in phenylacetate degradation YP_002926422.1 MG1655 equivalent: b1396 YP_002926423.1 catalyzes the thiolytic cleavage of beta-ketoadipyl-CoA to succinate and acetyl-CoA YP_002926424.1 MG1655 equivalent: b1398 YP_002926425.1 MG1655 equivalent: b1399 YP_002926426.1 MG1655 equivalent: b1400 YP_002926427.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats YP_002926428.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats YP_002926429.1 MG1655 equivalent: b1404 YP_002926430.1 MG1655 equivalent: b1406 YP_002926431.1 MG1655 equivalent: b1407 YP_002926432.1 MG1655 equivalent: b1408 YP_002926433.1 MG1655 equivalent: b1409 YP_002926434.1 MG1655 equivalent: b1410 YP_002926435.1 MG1655 equivalent: b1411 YP_002926436.1 FMN-dependent; requires NADH; catalyzes the cleavage of azo bond in aromatic azo compounds YP_002926437.1 involved in the post-transcriptional processing of the daa operon mRNA, which encodes proteins involved in fimbrial biogenesis of an enteropathogenic E. coli strain YP_002926438.1 MG1655 equivalent: b1414 YP_002926439.1 NAD-linked YP_002926440.1 B-type di-heme cytochrome with a major alpha-absorption peak at 561 nm and a minor peak at 555 nm YP_002926441.1 MG1655 equivalent: b1419 YP_002926442.1 MG1655 equivalent: b4428 YP_002926443.1 MG1655 equivalent: b1420 YP_002926444.1 MG1655 equivalent: b1421 YP_002926445.1 MG1655 equivalent: b1422 YP_002926446.1 MG1655 equivalent: b1423 YP_002926447.1 involved in the control of the structural glucose backbone of osmoregulated periplasmic glucans YP_002926448.1 MG1655 equivalent: b1426 YP_002926449.1 MG1655 equivalent: b1427 YP_002926450.1 MG1655 equivalent: b1428 YP_002926451.1 MG1655 equivalent: b1429 YP_002926452.1 with TehA confers resistance to tellurite YP_002926453.1 MG1655 equivalent: b1431 YP_002926454.1 MG1655 equivalent: b1432 YP_002926455.1 MG1655 equivalent: b1433 YP_002926456.1 MG1655 equivalent: b1434 YP_002926457.1 MG1655 equivalent: b1435 YP_002926458.1 MG1655 equivalent: b1436 YP_002926459.1 MG1655 equivalent: b4532 YP_002926460.1 MG1655 equivalent: b1438 YP_002926461.1 MG1655 equivalent: b1439 YP_002926462.1 MG1655 equivalent: b1440 YP_002926463.1 MG1655 equivalent: b1441 YP_002926464.1 MG1655 equivalent: b1442 YP_002926465.1 MG1655 equivalent: b1443 YP_002926466.1 catalyzes the formation of 4-aminobutanoate from 4-aminobutanal; involved in putrescine degradation YP_002926467.1 MG1655 equivalent: b4598 YP_002926468.1 MG1655 equivalent: b1445 YP_002926469.1 MG1655 equivalent: b1446 YP_002926470.1 MG1655 equivalent: b1447 YP_002926471.1 MG1655 equivalent: b1448 YP_002926472.1 MG1655 equivalent: b1449 YP_002926473.1 MG1655 equivalent: b1450 YP_002926474.1 MG1655 equivalent: b1451 YP_002926475.1 MG1655 equivalent: b1452 YP_002926476.1 MG1655 equivalent: b1453 YP_002926477.1 MG1655 equivalent: b1454 YP_002926478.1 MG1655 equivalent: b1455 YP_002926479.1 MG1655 equivalent: b1457 YP_002926480.1 MG1655 equivalent: b1460 YP_002926481.1 4-OT; member of subfamily 5; forms a dimer; the function in the Escherichia coli cell is unknown YP_002926482.1 MG1655 equivalent: b1462 YP_002926483.1 MG1655 equivalent: b1463 YP_002926484.1 MG1655 equivalent: b1464 YP_002926485.1 MG1655 equivalent: b1465 YP_002926486.1 MG1655 equivalent: b1466 YP_002926487.1 MG1655 equivalent: b1467 YP_002926488.1 MG1655 equivalent: b1468 YP_002926489.1 MG1655 equivalent: b1469 YP_002926490.1 MG1655 equivalent: b1470 YP_002926491.1 MG1655 equivalent: b1473 YP_002926492.1 MG1655 equivalent: b1474 YP_002926493.1 MG1655 equivalent: b1475 YP_002926494.1 nitrate-inducible, cytochrome b556(fdn) component of formate dehydrogenase YP_002926495.1 MG1655 equivalent: b1477 YP_002926496.1 similar to zinc-dependent eukaryotic ADH enzymes and distinct from fermentative ADHs YP_002926497.1 malic enzyme; oxaloacetate-decarboxylating; NAD-dependent; catalyzes the formation of pyruvate form malate YP_002926498.1 protein D; stationary-phase-induced ribosome-associated; in Escherichia coli this protein becomes associated with the ribosome; expression increases during stationary phase YP_002926499.1 MG1655 equivalent: b1481 YP_002926500.1 MG1655 equivalent: b1482 YP_002926501.1 MG1655 equivalent: b1483 YP_002926502.1 MG1655 equivalent: b1484 YP_002926503.1 MG1655 equivalent: b1485 YP_002926504.1 MG1655 equivalent: b1486 YP_002926505.1 MG1655 equivalent: b1487 YP_002926506.1 catalyzes the hydrolysis of D-alanyl-D-alanine dipeptide: Zn dependent; involved in peptidoglycan synthesis YP_002926507.1 heme-regulated phosphodiesterase with phosphodiesterase activity with cAMP but not with cGMP, bis(p-nitrophenyl) phosphate or p-nitrophenyl phosphate YP_002926508.1 MG1655 equivalent: b1490 YP_002926509.1 MG1655 equivalent: b1491 YP_002926510.1 MG1655 equivalent: b1492 YP_002926511.1 MG1655 equivalent: b1493 YP_002926512.1 MG1655 equivalent: b1494 YP_002926513.1 MG1655 equivalent: b1495 YP_002926514.1 MG1655 equivalent: b1496 YP_002926515.1 MG1655 equivalent: b1497 YP_002926516.1 MG1655 equivalent: b1498 YP_002926517.1 regulates the cellular response to acid resistance YP_002926518.1 MG1655 equivalent: b1500 YP_002926519.1 in Escherichia coli it may be involved in repression of type III secretion system (TTSS) genes of the host cell; involved with increased resistance to low pH; member of the prokaryotic molybdopterin-containing oxidoreductase family YP_002926520.1 MG1655 equivalent: b1502 YP_002926521.1 MG1655 equivalent: b1503 YP_002926522.1 MG1655 equivalent: b1504 YP_002926523.1 MG1655 equivalent: b1507 YP_002926524.1 MG1655 equivalent: b1508 YP_002926525.1 MG1655 equivalent: b1509 YP_002926526.1 MG1655 equivalent: b1510 YP_002926527.1 MG1655 equivalent: b1511 YP_002926528.1 MG1655 equivalent: b1512 YP_002926529.1 MG1655 equivalent: b1513 YP_002926530.1 MG1655 equivalent: b1514 YP_002926531.1 MG1655 equivalent: b1515 YP_002926532.1 MG1655 equivalent: b1516 YP_002926533.1 MG1655 equivalent: b1517 YP_002926534.1 MG1655 equivalent: b1518 YP_002926535.1 catalyzes the formation of (E)-3-(methoxycarbonyl)pent-2-enedioate and S-adenosyl-L-homocysteine from S-adenosyl-L-methionine and trans-aconitate YP_002926536.1 MG1655 equivalent: b1520 YP_002926537.1 catalyzes the formation of D-tagaturonate from D-altronate YP_002926538.1 MG1655 equivalent: b1522 YP_002926539.1 MG1655 equivalent: b1523 YP_002926540.1 catalyzes the formation of glutamate from glutamine YP_002926541.1 in Escherichia coli this enzyme appears to be an NAD+/NADP+-dependent succinate semialdehyde dehydrogenase YP_002926542.1 MG1655 equivalent: b1526 YP_002926543.1 MG1655 equivalent: b1527 YP_002926544.1 MG1655 equivalent: b1528 YP_002926545.1 protein involved in resistance to different drugs (tetracycline, chloramphenicol, beta-lactams, and quinolones); part of the multiple antibiotic resistance (mar) locus, which is composed by the genes marC and marRAB; unknown function YP_002926546.1 Repressor of the marRAB operon which is involved in the activation of both antibiotic resistance and oxidative stress genes YP_002926547.1 transcriptional activator of genes involved in the multiple antibiotic resistance (Mar) phenotype; also activates sodA, zwf and micF YP_002926548.1 MG1655 equivalent: b1532 YP_002926549.1 MG1655 equivalent: b1533 YP_002926550.1 YdeF; uncharacterized member of the major facilitator superfamily (MFS) of transporters YP_002926551.1 MG1655 equivalent: b4599 YP_002926552.1 MG1655 equivalent: b1535 YP_002926553.1 MG1655 equivalent: b1536 YP_002926554.1 MG1655 equivalent: b1537 YP_002926555.1 MG1655 equivalent: b1538 YP_002926556.1 NADP(+)-dependent; catalyzes the formation of 2-aminomalonate-semialdehyde from L-serine; can also use 3-hydroxybutyrate, 3-hydroxy-isobutyrate, D-threonine, L-allo-threonine,D-serine YP_002926557.1 MG1655 equivalent: b1540 YP_002926558.1 MG1655 equivalent: b1541 YP_002926559.1 MG1655 equivalent: b1542 YP_002926560.1 MG1655 equivalent: b1544 YP_002926561.1 MG1655 equivalent: b1545 YP_002926562.1 MG1655 equivalent: b1546 YP_002926563.1 MG1655 equivalent: b1547 YP_002926564.1 MG1655 equivalent: b4533 YP_002926565.1 MG1655 equivalent: b1549 YP_002926566.1 MG1655 equivalent: b1550 YP_002926567.1 MG1655 equivalent: b1551 YP_002926568.1 MG1655 equivalent: b1552 YP_002926569.1 MG1655 equivalent: b1553 YP_002926570.1 MG1655 equivalent: b1554 YP_002926571.1 MG1655 equivalent: b1555 YP_002926572.1 MG1655 equivalent: b1556 YP_002926573.1 MG1655 equivalent: b1557 YP_002926574.1 MG1655 equivalent: b1558 YP_002926575.1 MG1655 equivalent: b1559 YP_002926576.1 MG1655 equivalent: b1560 YP_002926577.1 MG1655 equivalent: b1561 YP_002926578.1 MG1655 equivalent: b1562 YP_002926579.1 MG1655 equivalent: b1563 YP_002926580.1 Qin prophage; bifunctional antitoxin of the RelE-RelB toxin-antitoxin system/transcriptional repressor YP_002926581.1 MG1655 equivalent: b1565 YP_002926582.1 MG1655 equivalent: b1566 YP_002926583.1 MG1655 equivalent: b1567 YP_002926584.1 MG1655 equivalent: b1568 YP_002926585.1 MG1655 equivalent: b1569 YP_002926586.1 The transcriptional repressor of DicA (divison cell) has a hypothetical DNA binding domain. It represses the transcription of dicB and dicC, but its specific role in cellular replication and mode of action are still unknown. YP_002926587.1 MG1655 equivalent: b1571 YP_002926588.1 MG1655 equivalent: b1572 YP_002926589.1 MG1655 equivalent: b1575 YP_002926590.1 MG1655 equivalent: b1576 YP_002926591.1 MG1655 equivalent: b1580 YP_002926592.1 MG1655 equivalent: b1581 YP_002926593.1 MG1655 equivalent: b1582 YP_002926594.1 MG1655 equivalent: b1583 YP_002926595.1 MG1655 equivalent: b1584 YP_002926596.1 MG1655 equivalent: b1585 YP_002926597.1 MG1655 equivalent: b1586 YP_002926598.1 MG1655 equivalent: b1587 YP_002926599.1 MG1655 equivalent: b1588 YP_002926600.1 MG1655 equivalent: b1589 YP_002926601.1 MG1655 equivalent: b1590 YP_002926602.1 binds to the twin-arginine signal peptides of certain proteins, including dimethylsulfoxide reductase and trimethylamine N-oxide reductase that are translocated to the cytoplasmic membrane YP_002926603.1 MG1655 equivalent: b1592 YP_002926604.1 DTB synthetase; dethiobiotin synthase; involved in production of dethiobiotin from ATP and 7,8-diaminononanoate and carbon dioxide; contains magnesium YP_002926605.1 MG1655 equivalent: b1594 YP_002926606.1 MG1655 equivalent: b1595 YP_002926607.1 MG1655 equivalent: b1596 YP_002926608.1 required for growth and survival under moderately acid conditions YP_002926609.1 MG1655 equivalent: b4601 YP_002926610.1 MG1655 equivalent: b1598 YP_002926611.1 with MdtJ is involved in resistance to deoxycholate, nalidixic acid, fosfomycin, and SDS YP_002926612.1 with MdtI is involved in resistance to deoxycholate , nalidixic acid, fosfomycin, and SDS YP_002926613.1 transport of quorum-sensing signal; mutations in this gene alters the transport of the quorum-sensing signal autoinducer 2 (AI-2) which affects expression of a large number of genes YP_002926614.1 catalyzes reversible transfer of hydride ion equivalent between NAD and NADP; membrane-bound proton pump that translocates protons from cytosolic to periplasmic side of the inner membrane; forms a tetramer composed of two alpha and 2 beta subunits; AB-stereospecific enzyme YP_002926615.1 forms a tetramer composed of 2 alpha subunits and 2 beta subunits in the inner membrane; involved in catalyzing transfer of hydride ion equivalents between NAD and NADP; stereospecific (AB-specific); functions as a proton pump by translocating protons from cytoplasm to periplasm YP_002926616.1 MG1655 equivalent: b1604 YP_002926617.1 MG1655 equivalent: b1605 YP_002926618.1 MG1655 equivalent: b1606 YP_002926619.1 MG1655 equivalent: b1607 YP_002926620.1 response regulator in two-component regulatory system with RstB YP_002926621.1 MG1655 equivalent: b1609 YP_002926622.1 binds to DNA replication terminator sequences to prevent passage of replication forks YP_002926623.1 class II family (does not require metal); tetrameric enzyme; fumarase C; reversibly converts (S)-malate to fumarate and water; functions in the TCA cycle YP_002926624.1 MG1655 equivalent: b1612 YP_002926625.1 MG1655 equivalent: b1613 YP_002926626.1 MG1655 equivalent: b1614 YP_002926627.1 MG1655 equivalent: b1615 YP_002926628.1 MG1655 equivalent: b1617 YP_002926629.1 MG1655 equivalent: b1618 YP_002926630.1 Acts on the hydroxyl group at position 7 of the steroid frame YP_002926631.1 regulates malXY which are involved in maltose-glucose transport YP_002926632.1 phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS); catalyzes the phosphorylation of maltose and glucose concomitant with their translocation across the cell membrane; component IIB catalyzes the phosphorylation of the sugar molecule; IIC forms the translocation channel and contains the substrate specific binding site YP_002926633.1 MG1655 equivalent: b1622 YP_002926634.1 catalyzes the formation of inosine from adenosine YP_002926635.1 MG1655 equivalent: b1624 YP_002926636.1 MG1655 equivalent: b4409 YP_002926637.1 YdgT; in E. coli, when complexed with H-NS or StpA binds a 26 base-pair DNA sequence of oriC; seems to play a role in optimizing the activity of oriC; non-essential; Hha protein paralog; in an hha mutant background, cnu is overexpressed and can compensate hha-induced phenotypes YP_002926638.1 MG1655 equivalent: b1626 YP_002926639.1 MG1655 equivalent: b1627 YP_002926640.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_002926641.1 part of membrane-bound complex thought to be involved in electron transport to nitrogen YP_002926642.1 RnfD; RsxD; required for nitrogen fixation in Rhodobacter capsulatus; part of a membrane-bound complex thought to be involved in electron transport to nitrogenase; in Escherichia coli this gene is part of a cluster controlling SoxR-mediated induction of the SoxS transcription factor in the absence of oxidizing agents YP_002926643.1 part of membrane-bound complex hought to be involved in electron transport to nitrogen YP_002926644.1 in Excherichia coli RsxABCDEG reduces SoxR which turns off induction of SoxS transcription factor in the absence of oxidizing agents; similar to the rnfABCDGE operon in Rhodobacter capsulatus involved in transferring electrons to nitrogenase YP_002926645.1 DNA-(apurinic or apyrimidinic site) lyase; has apurinic or apyrimidinic endonuclease activity and DNA N-glycosylase activity; removed damaged DNA at cytosines, thymines and guanines YP_002926646.1 mutations in this gene confer resistance to the toxic peptide alafosfalin in Salmonella typhimurium; member of proton-dependent oligopeptide transport (POT) system family; in Escherichia coli this gene is regulated by OmpR although not via osmoregulation YP_002926647.1 MG1655 equivalent: b1635 YP_002926648.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_002926649.1 catalyzes the formation of tyrosyl-tRNA(Tyr) from tyrosine and tRNA(Tyr) YP_002926650.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxamine 5'-phosphate YP_002926651.1 MliC; membrane-bound lysozyme inhibitor of c-type lysozyme YP_002926652.1 catalyzes hydrolysis of 1,6-anhydro bond of anyhydro-N-acetylmuramic acid (anhMurNAc) and phosphorylates anhMurNAc to produce N-acetyl-muramate-6-phosphate; involved in murein recycling YP_002926653.1 MG1655 equivalent: b1641 YP_002926654.1 Transcription regulator that can both activate or repress expression YP_002926655.1 MG1655 equivalent: b1643 YP_002926656.1 MG1655 equivalent: b1644 YP_002926657.1 MG1655 equivalent: b1645 YP_002926658.1 SodC; copper and zinc binding; converts superoxide radicals to hydrogen peroxide and water YP_002926659.1 MG1655 equivalent: b1647 YP_002926660.1 MG1655 equivalent: b1648 YP_002926661.1 MG1655 equivalent: b1649 YP_002926662.1 FMN-linked; catalyzes the formation of N-ethylsuccinimide from N-ethylmaleimide YP_002926663.1 Ni-dependent; catalyzes the formation of S-lactoylglutathione from methylglyoxal and glutathione YP_002926664.1 Responsible for the end-turnover of tRNA: specifically removes the terminal AMP residue from uncharged tRNA (tRNA-C-C-A) YP_002926665.1 similar to the DNA and RNA helicase superfamily II and eukaryotic DEAD family of helicases; longest known protein in E. coli YP_002926666.1 MG1655 equivalent: b1654 YP_002926667.1 MG1655 equivalent: b1655 YP_002926668.1 SodB; iron binding; present under aerobic and anaerobic conditions; destroys free radicals YP_002926669.1 MG1655 equivalent: b1657 YP_002926670.1 MG1655 equivalent: b4602 YP_002926671.1 binds to the purF operator and coregulates other genes for de novo purine nucleotide synthesis; is involved in regulation of purB, purC, purEK, purHD, purL, purMN and guaBA expression; binds hypoxanthine and guanine as inducers YP_002926672.1 MG1655 equivalent: b1659 YP_002926673.1 uncharacterized member of the major facilitator superfamily (MFS) YP_002926674.1 catalyzes the transfer of a methylene group from S-adenosyl-L-methionine to the cis double bond of an unsaturated fatty acid chain resulting in the replacement of the double bond with a methylene bridge YP_002926675.1 catalyzes the formation of riboflavin from 6,7-dimethyl-8-(1-D-ribityl)lumazine YP_002926676.1 NorM; MdtK; functions as a Na(+)/drug antiporter; inactivation in Vibrio cholerae results in susceptibility to fluoroquinolones YP_002926677.1 MG1655 equivalent: b1664 YP_002926678.1 MG1655 equivalent: b1667 YP_002926679.1 MG1655 equivalent: b1668 YP_002926680.1 MG1655 equivalent: b1669 YP_002926681.1 MG1655 equivalent: b1670 YP_002926682.1 MG1655 equivalent: b1671 YP_002926683.1 MG1655 equivalent: b1672 YP_002926684.1 MG1655 equivalent: b1673 YP_002926685.1 MG1655 equivalent: b1674 YP_002926686.1 MG1655 equivalent: b1675 YP_002926687.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002926688.1 MG1655 equivalent: b1677 YP_002926689.1 MG1655 equivalent: b1678 YP_002926690.1 Acts with SufS to catalyze the formation of L-alanine from L-cysteine YP_002926691.1 catalyzes the formation of L-alanine and selenide or sulfanylcysteine from selenocysteine or cysteine YP_002926692.1 with SufBC activates cysteine desulfurase SufS YP_002926693.1 part of SUF system involved in inserting iron-sulfur clusters into proteins; in Escherichia coli this protein forms a complex with SufBD; the SufBCD complex stimulates the cysteine desulfurase SufS in conjunction with SufE YP_002926694.1 with SufCD activates cysteine desulfurase SufS YP_002926695.1 functions as a scaffold on which iron-sulfur clusters ([2Fe-2S]; [4Fe-4S]) are assembled; forms a homodimer; similar to IscA protein YP_002926696.1 MG1655 equivalent: b1685 YP_002926697.1 MG1655 equivalent: b1686 YP_002926698.1 MG1655 equivalent: b1687 YP_002926699.1 YdiK; inner membrane protein; ydiK promoter presents a PurR sequence, suggesting that its expression is purine-regulated; unknown function YP_002926700.1 MG1655 equivalent: b1689 YP_002926701.1 MG1655 equivalent: b1690 YP_002926702.1 MG1655 equivalent: b1691 YP_002926703.1 YdiB; quinate/shikimate dehydrogenase from Escherichia coli uses both NAD and NAD(P) to convert quinate and shikimate to 3-dehydroquinate and 3-dehydroshikimate YP_002926704.1 catalyzes the dehydration of 3-dehydroquinate to form 3-dehydroshikimate in aromatic amino acid biosynthesis YP_002926705.1 MG1655 equivalent: b1694 YP_002926706.1 may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain YP_002926707.1 MG1655 equivalent: b1696 YP_002926708.1 YdiO, YdiQ, YdiR, YdiS, and YdiT may play a role in electron transport between the anaerobic fatty acid oxidation pathway and the respiratory chain YP_002926709.1 May play a role in a redox process YP_002926710.1 MG1655 equivalent: b1699 YP_002926711.1 MG1655 equivalent: b1700 YP_002926712.1 acts in anaerobic beta-oxidation of fatty acids; possible ligase/synthase involved in anaerobic growth on fatty acids YP_002926713.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002926714.1 MG1655 equivalent: b1703 YP_002926715.1 tryptophan sensitive; catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate YP_002926716.1 MG1655 equivalent: b1705 YP_002926717.1 MG1655 equivalent: b1706 YP_002926718.1 MG1655 equivalent: b1707 YP_002926719.1 MG1655 equivalent: b1708 YP_002926720.1 ATP-binding protein that acts with the transmembrane protein BtuC and the solute binding protein BtuF to transport vitamin B12 into the cell YP_002926721.1 similar to glutathione peroxidase; member of the btuCED operon which is required for vitamin B12 transport across the inner membrane YP_002926722.1 with BtuD and BtuF transports vitamin B12 into the cell YP_002926723.1 This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control YP_002926724.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a tetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 2 subfamily YP_002926725.1 catalyzes a two-step reaction, first charging a phenylalanine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; forms a heterotetramer of alpha(2)beta(2); binds two magnesium ions per tetramer; type 1 subfamily YP_002926727.1 binds directly to 23S ribosomal RNA prior to in vitro assembly of the 50S ribosomal subunit YP_002926728.1 MG1655 equivalent: b1717 YP_002926729.1 IF-3 has several functions that are required and promote translation initiation including; preventing association of 70S by binding to 30S; monitoring codon-anticodon interactions by promoting disassociation of fMet-tRNA(fMet) from initiation complexes formed on leaderless mRNAs or incorrectly bound noninitiatior tRNAs and complexes with noncanonical start sites; stimulates codon-anticodon interactions at P-site; involved in moving mRNA to the P-site; and in recycling subunits YP_002926730.1 catalyzes the formation of threonyl-tRNA(Thr) from threonine and tRNA(Thr); catalyzes a two-step reaction, first charging a threonine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002926731.1 MG1655 equivalent: b4535 YP_002926732.1 MG1655 equivalent: b1722 YP_002926733.1 MG1655 equivalent: b1723 YP_002926734.1 MG1655 equivalent: b1724 YP_002926735.1 MG1655 equivalent: b1725 YP_002926736.1 MG1655 equivalent: b1726 YP_002926737.1 YniC; catalyzes the dephosphorylation of 2-deoxyglucose 6-phosphate, mannose 6-phosphate and p-nitrophenyl phosphate YP_002926738.1 MG1655 equivalent: b1728 YP_002926739.1 MG1655 equivalent: b1729 YP_002926740.1 MG1655 equivalent: b1730 YP_002926741.1 MG1655 equivalent: b1731 YP_002926742.1 Catalase HPII; monofunctional catalase that decomposes hydrogen peroxide into water and oxygen; serves to protect cells from the toxic effects of hydrogen peroxide YP_002926743.1 MG1655 equivalent: b1733 YP_002926744.1 MG1655 equivalent: b1734 YP_002926745.1 represses the celABCDF-ydjC operon involved in carbon uptake YP_002926746.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_002926747.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_002926748.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N,N'-diacetylchitobiose transport; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_002926749.1 osmotically-inducible lipoprotein E; activator of ntr-like gene protein YP_002926750.1 catalyzes the formation of nicotinamide adenine dinucleotide (NAD) from nicotinic acid adenine dinucleotide (NAAD) using either ammonia or glutamine as the amide donor and ATP; ammonia-utilizing enzymes include the ones from Bacillus and Escherichia coli while glutamine-utilizing enzymes include the Mycobacterial one; forms homodimers YP_002926751.1 3' incision activity; acts with UvrC YP_002926752.1 MG1655 equivalent: b1742 YP_002926753.1 periplasmic protein induced by stress response via Cpx and BaeSR system; similar to CpxP YP_002926754.1 catalyzes the formation of succinate and glutamate from N(2)-succinylglutamate in arginine catabolism YP_002926755.1 catalyzes the hydrolysis of 2-N-succinylarginine into 2-N-succinylornithine, ammonia and carbon dioxide in arginine degradation YP_002926756.1 a high throughput screen identified this enzyme as an aldehyde dehydrogenase with broad substrate specificity; converts succinylglutamate semialdehyde and NAD to succinylglutamate and NADH YP_002926757.1 MG1655 equivalent: b1747 YP_002926758.1 catalyzes the transamination of 2-N-succinylornithine and alpha-ketoglutarate into 2-N-succinylglutamate semialdehyde and glutamate; also functions as the catabolic acetylornithine aminotransferase catalyzing the formation of 2-N-acetylglutamate semialdehyde and glutamate from 2-N-acetylornithine and alpha-ketoglutarate YP_002926759.1 removes the damaged DNA at cytosines and guanines by cleaving on the 3' side of the AP site by a beta-elimination reaction YP_002926760.1 MG1655 equivalent: b1750 YP_002926761.1 MG1655 equivalent: b1751 YP_002926762.1 MG1655 equivalent: b1752 YP_002926763.1 MG1655 equivalent: b1753 YP_002926764.1 MG1655 equivalent: b1754 YP_002926765.1 MG1655 equivalent: b1755 YP_002926766.1 MG1655 equivalent: b1756 YP_002926767.1 MG1655 equivalent: b1757 YP_002926768.1 MG1655 equivalent: b1758 YP_002926769.1 MG1655 equivalent: b1759 YP_002926770.1 MG1655 equivalent: b1760 YP_002926771.1 converts 2-oxoglutarate to glutamate; in Escherichia coli this enzyme plays a role in glutamate synthesis when the cell is under energy restriction; uses NADPH; forms a homohexamer YP_002926772.1 MG1655 equivalent: b1762 YP_002926773.1 decatenates replicating daughter chromosomes YP_002926774.1 catalyzes the formation of selenophosphate from selenide and ATP YP_002926775.1 MG1655 equivalent: b1765 YP_002926776.1 SppA; catalyzes the degradation of cleaved signal peptides; essential to maintain secretion of mature proteins across the membrane YP_002926777.1 converts asparagine to aspartate and ammonia YP_002926778.1 catalyzes the formation of nicotinate from nicotinamide in NAD biosynthesis and the formation of pyrazinoate from pyrazinamide YP_002926779.1 MG1655 equivalent: b1769 YP_002926780.1 MG1655 equivalent: b1770 YP_002926781.1 MG1655 equivalent: b1771 YP_002926782.1 MG1655 equivalent: b1772 YP_002926783.1 MG1655 equivalent: b1773 YP_002926784.1 MG1655 equivalent: b1774 YP_002926785.1 MG1655 equivalent: b1775 YP_002926786.1 MG1655 equivalent: b1776 YP_002926787.1 MG1655 equivalent: b1777 YP_002926788.1 this stereospecific enzymes reduces the R isomer of methionine sulfoxide while MsrA reduces the S form; provides protection against oxidative stress YP_002926789.1 MG1655 equivalent: b1779 YP_002926790.1 MG1655 equivalent: b1780 YP_002926791.1 MG1655 equivalent: b1781 YP_002926792.1 MG1655 equivalent: b1782 YP_002926793.1 MG1655 equivalent: b1783 YP_002926794.1 MG1655 equivalent: b1784 YP_002926795.1 MG1655 equivalent: b1785 YP_002926796.1 MG1655 equivalent: b1786 YP_002926797.1 MG1655 equivalent: b1787 YP_002926798.1 MG1655 equivalent: b1788 YP_002926799.1 MG1655 equivalent: b1789 YP_002926800.1 MG1655 equivalent: b1790 YP_002926801.1 MG1655 equivalent: b1791 YP_002926802.1 MG1655 equivalent: b1792 YP_002926803.1 MG1655 equivalent: b1793 YP_002926804.1 MG1655 equivalent: b1794 YP_002926805.1 MG1655 equivalent: b1795 YP_002926806.1 MG1655 equivalent: b1796 YP_002926807.1 MG1655 equivalent: b1797 YP_002926808.1 MG1655 equivalent: b1798 YP_002926809.1 MG1655 equivalent: b1799 YP_002926810.1 MG1655 equivalent: b1800 YP_002926811.1 member of the betaine, carnitine, choline transporter (BCCT) family; unknown function YP_002926812.1 MG1655 equivalent: b1802 YP_002926813.1 MG1655 equivalent: b1803 YP_002926814.1 MG1655 equivalent: b1804 YP_002926815.1 Activates fatty acids by binding to coenzyme A YP_002926816.1 MG1655 equivalent: b1806 YP_002926817.1 MG1655 equivalent: b1807 YP_002926818.1 MG1655 equivalent: b1808 YP_002926819.1 MG1655 equivalent: b1809 YP_002926820.1 MG1655 equivalent: b1810 YP_002926821.1 MG1655 equivalent: b1811 YP_002926822.1 MG1655 equivalent: b1812 YP_002926823.1 MG1655 equivalent: b1813 YP_002926824.1 MG1655 equivalent: b1814 YP_002926825.1 MG1655 equivalent: b1815 YP_002926826.1 MG1655 equivalent: b1816 YP_002926827.1 MG1655 equivalent: b1817 YP_002926828.1 MG1655 equivalent: b1818 YP_002926829.1 hosphoenolpyruvate-dependent sugar phosphotransferase system catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IID with IIC forms the translocation channel YP_002926830.1 MG1655 equivalent: b1820 YP_002926831.1 membrane protein YebN YP_002926832.1 methylates the guanosine in position 745 of 23S rRNA; required for translation and cell growth YP_002926833.1 MG1655 equivalent: b1823 YP_002926834.1 MG1655 equivalent: b1824 YP_002926835.1 MG1655 equivalent: b1825 YP_002926836.1 MG1655 equivalent: b1826 YP_002926837.1 MG1655 equivalent: b4536 YP_002926838.1 MG1655 equivalent: b1827 YP_002926839.1 MG1655 equivalent: b1828 YP_002926840.1 putative metalloprotease YP_002926841.1 Involved in the cleavage of a C-terminal peptide of 11 residues from the precursor form of penicillin-binding protein 3 YP_002926842.1 affects solute and DNA transport through an unknown mechanism YP_002926843.1 MG1655 equivalent: b1832 YP_002926844.1 MG1655 equivalent: b1833 YP_002926845.1 MG1655 equivalent: b1834 YP_002926846.1 in Escherichia coli this enzyme specifically methylates C1407 of the 16S rRNA YP_002926847.1 MG1655 equivalent: b1836 YP_002926848.1 MG1655 equivalent: b1837 YP_002926849.1 Plays a key role in signaling protein misfolding via the cpxR/cpxA transducing system; modulates the phosphorylated status of many phosphoproteins YP_002926850.1 MG1655 equivalent: b1839 YP_002926851.1 MG1655 equivalent: b1840 YP_002926852.1 MG1655 equivalent: b1841 YP_002926853.1 MG1655 equivalent: b1842 YP_002926854.1 MG1655 equivalent: b1843 YP_002926855.1 3'-5' exonuclease activity on single or double-strand DNA YP_002926856.1 PtrB; oligopeptidase that cleaves peptide bonds following arginine and lysine residues YP_002926857.1 MG1655 equivalent: b1846 YP_002926858.1 secreted protein; unknown function YP_002926859.1 MG1655 equivalent: b1848 YP_002926860.1 non-folate utilizing enzyme, catalyzes the production of beta-formyl glycinamide ribonucleotide from formate, ATP, and beta-GAR and a side reaction producing acetyl phosphate and ADP from acetate and ATP; involved in de novo purine biosynthesis YP_002926861.1 catalyzes the formation of pyruvate and glyoxylate from 4-hydroxy-2-oxoglutarate; or pyruvate and D-glyceraldehyde 3-phosphate from 2-dehydro-3-deoxy-D-glyconate 6-phosphate YP_002926862.1 catalyzes the formation of 2-dehydro-3-deoxy-6-phospho-D-gluconate from 6-phospho-D-gluconate YP_002926863.1 catalyzes the formation of D-glucono-1,5-lactone 6-phosphate from D-glucose 6-phosphate YP_002926864.1 Represses the expression of the zwf, eda, glp and gap YP_002926865.1 catalyzes the formation of phosphoenolpyruvate from pyruvate YP_002926866.1 Transfers myristate or laurate, activated on ACP, to the lipid IVA moiety of (KDO)2-(lauroyl)-lipid IVA YP_002926867.1 MG1655 equivalent: b1856 YP_002926868.1 involved in transport of zinc(II) with ZnuA and C YP_002926869.1 involved in transport of zinc(II) with ZnuA and C YP_002926870.1 involved in transport of zinc(II) with ZnuA and C YP_002926871.1 promotes strand exchange during homologous recombination; RuvAB complex promotes branch migration; RuvABC complex scans the DNA during branch migration and resolves Holliday junctions at consensus sequences; forms hexameric rings around opposite DNA arms; requires ATP for branch migration and orientation of RuvAB complex determines direction of migration YP_002926872.1 plays an essential role in ATP-dependent branch migration of the Holliday junction YP_002926873.1 MG1655 equivalent: b1862 YP_002926874.1 endonuclease; resolves Holliday structures; forms a complex of RuvABC; the junction binding protein RuvA forms a hexameric ring along with the RuvB helicase and catalyzes branch migration; RuvC then interacts with RuvAB to resolve the Holliday junction by nicking DNA strands of like polarity YP_002926875.1 MG1655 equivalent: b1864 YP_002926876.1 converts dATP to dAMP and pyrophosphate YP_002926877.1 catalyzes a two-step reaction, first charging an aspartate molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; contains discriminating and non-discriminating subtypes YP_002926878.1 MG1655 equivalent: b1867 YP_002926879.1 MG1655 equivalent: b1868 YP_002926880.1 MG1655 equivalent: b1869 YP_002926881.1 MG1655 equivalent: b1870 YP_002926882.1 MG1655 equivalent: b1871 YP_002926883.1 MG1655 equivalent: b1872 YP_002926884.1 MG1655 equivalent: b1873 YP_002926885.1 MG1655 equivalent: b1874 YP_002926886.1 MG1655 equivalent: b1875 YP_002926887.1 catalyzes a two-step reaction, first charging an arginine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class-I aminoacyl-tRNA synthetase YP_002926888.1 MG1655 equivalent: b1877 YP_002926889.1 MG1655 equivalent: b1878 YP_002926890.1 membrane protein involved in the flagellar export apparatus YP_002926891.1 membrane protein responsible for substrate specificity switching from rod/hook-type export to filament-type export YP_002926892.1 cytosolic phosphatase which functions in the chemotaxis signal transduction complex by controlling the level of phosphorylated CheY through dephosphorylation YP_002926893.1 chemotaxis regulator that, when phosphorylated, interacts with the flagellar motor causing the flagella to spin clockwise which causes the cell to tumble YP_002926894.1 regulates chemotaxis by demethylation of methyl-accepting chemotaxis proteins YP_002926895.1 methylates the MCP YP_002926896.1 mediates taxis toward dipeptides YP_002926897.1 MG1655 equivalent: b1886 YP_002926898.1 MG1655 equivalent: b1887 YP_002926899.1 chemotactic sensory histidine kinase in two-component regulatory system with CheB and CheY; sensory histidine kinase/signal sensing protein; CheA is the histidine kinase component YP_002926900.1 with MotA forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_002926901.1 With MotB forms the ion channels that couple flagellar rotation to proton/sodium motive force across the membrane and forms the stator elements of the rotary flagellar machine YP_002926902.1 With FlhD is involved in the activation of class 2 flagellar genes and as well as a number of other genetic systems YP_002926904.1 ppGpp-dependent; membrane-associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_002926905.1 MG1655 equivalent: b1896 YP_002926906.1 biosynthetic; catalyzes the formation of trehalose and phosphate from trehalose-6-phosphate; expression is increased under osmotic stress and induced during the transition to stationary phase and by decreased temperature YP_002926907.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_002926908.1 Part of the ABC transporter complex AraFGH involved in the high affinity transport of arabinose YP_002926909.1 MG1655 equivalent: b1901 YP_002926910.1 MG1655 equivalent: b1902 YP_002926911.1 MG1655 equivalent: b4537 YP_002926912.1 MG1655 equivalent: b1904 YP_002926913.1 cytoplasmic iron storage protein YP_002926914.1 MG1655 equivalent: b1906 YP_002926915.1 MG1655 equivalent: b1907 YP_002926916.1 MG1655 equivalent: b1908 YP_002926917.1 MG1655 equivalent: b1912 YP_002926918.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision YP_002926919.1 in Escherichia coli the protein UvrY is part of a two-component system along with BarA that is needed for efficient switching between glycolytic and gluconeogenic carbon sources possibly by regulating the Csr system; in Salmonella SirA and BarA regulate virulence gene expression also via the Csr system YP_002926920.1 MG1655 equivalent: b1915 YP_002926921.1 regulates genes involved in cell division YP_002926922.1 MG1655 equivalent: b1917 YP_002926923.1 MG1655 equivalent: b1918 YP_002926924.1 catalyzes the formation of pyruvate from D-cysteine YP_002926925.1 MG1655 equivalent: b1920 YP_002926926.1 expression activator of the class 2 type of flagellar operons, essential to achieve maximal cell motility; activator of type 1 fimbrial gene expression; cell density-responsive regulator; FliZ in Salmonella typhimurium induces HilA, an activator of invasion genes necessary to achieve full virulence YP_002926927.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor directs late flagellar biosynthesis genes YP_002926928.1 structural flagella protein; individual Salmonella serotypes usually alternate between the production of 2 antigenic forms of flagella, termed phase 1 and phase 2, each specified by separate structural genes YP_002926929.1 involved in flagellin assembly YP_002926930.1 flagellin specific chaperone YP_002926931.1 binds flagellar cap subunits (FliD) and seems to prevents their oligomerization prior to its translocation through the flagellum-specific type III export pathway; acts as a repressor of flagellar class 2 operons by preventing FlhD2C2 to bind the promoter and inhibiting the FlhD2C2-dependent transcription; member of the type III cytoplasmic chaperone family YP_002926932.1 converts 1,4-alpha-D-glucans to maltodextrin YP_002926933.1 MG1655 equivalent: b1928 YP_002926934.1 MG1655 equivalent: b1929 YP_002926935.1 MG1655 equivalent: b1930 YP_002926936.1 MG1655 equivalent: b1931 YP_002926937.1 MG1655 equivalent: b1932 YP_002926938.1 forms a junction between the M-ring and FlgB during flagella biosynthesis YP_002926939.1 the MS-ring anchors the flagellum to the cytoplasmic membrane; part of the flagellar basal body which consists of four rings L, P, S, and M mounted on a central rod YP_002926940.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002926941.1 binds to and inhibits the function of flagella specific ATPase FliI YP_002926942.1 involved in type III protein export during flagellum assembly YP_002926943.1 rod/hook and filament chaperone YP_002926944.1 MG1655 equivalent: b1943 YP_002926945.1 interacts with cytoplasmic MS ring of the basal body and may act to stabilize the MotAB complexes which surround the MS ring YP_002926946.1 with FliG and FliN makes up the switch complex which is involved in switching the direction of the flagella rotation YP_002926947.1 One of three proteins involved in switching the direction of the flagellar rotation YP_002926948.1 with FlhA, FlhB, FliP, FliQ and FliR is one of the membrane components of the flagellar export apparatus YP_002926949.1 FliP, with proteins FliQ and FliR, forms the core of the central channel in the flagella export apparatus YP_002926950.1 with proteins FliP and FliR forms the core of the central channel in the flagella export apparatus YP_002926951.1 FliR, with proteins FliP and FliQ, forms the core of the central channel in the flagella export apparatus YP_002926952.1 MG1655 equivalent: b1951 YP_002926953.1 MG1655 equivalent: b1952 YP_002926954.1 MG1655 equivalent: b1953 YP_002926955.1 catalyzes the hydrolysis of mannosyl-3-phosphoglycerate to form the osmolyte mannosylglycerate YP_002926956.1 MG1655 equivalent: b1956 YP_002926957.1 MG1655 equivalent: b1957 YP_002926958.1 MG1655 equivalent: b1958 YP_002926959.1 MG1655 equivalent: b1959 YP_002926960.1 MG1655 equivalent: b1960 YP_002926961.1 MG1655 equivalent: b1961 YP_002926962.1 MG1655 equivalent: b1962 YP_002926963.1 MG1655 equivalent: b1963 YP_002926964.1 Hsp31 stabilizes early unfolding protein intermediates under severe heat stress YP_002926965.1 MG1655 equivalent: b1968 YP_002926966.1 induced by CusR in the presence of copper; YedW induces the expression of the upstream gene yedV (encoding a sensor kinase) as well as yedW; yedVW is one of four copper regulons found in E. coli; part of the copper homeostasis mechanism; confers resistance to copper and several drugs when induced YP_002926967.1 MG1655 equivalent: b1970 YP_002926968.1 in Escherichia coli this periplasmic enzyme was found to encode the periplasmic catalytic subunit of an oxidoreductase; sulfite oxidase activity not demonstrated; requires inner membrane anchor protein YedZ YP_002926969.1 in Escherichia coli this inner membrane protein was found to anchor the periplasmic catalytic oxidoreductase YedY; sulfite oxidase activity not demonstrated; contains heme YP_002926970.1 MG1655 equivalent: b1973 YP_002926971.1 MG1655 equivalent: b1974 YP_002926972.1 MG1655 equivalent: b1976 YP_002926973.1 MG1655 equivalent: b1978 YP_002926974.1 MG1655 equivalent: b1981 YP_002926975.1 Catalyzes the hydrolysis of AMP to form adenine and ribose 5-phosphate using water as the nucleophile YP_002926976.1 MG1655 equivalent: b1983 YP_002926977.1 MG1655 equivalent: b1985 YP_002926978.1 LysR-type transcriptional regulator similar to CysB; contains helix-turn-helix (HTH) motif; in Escherichia coli this protein regulates two operons consisting of ABC transporters that are part of the cys regulon; regulated by CysB YP_002926979.1 Transcriptional activator for the hut, put and ure operons and repressor for the gdh and gltB operons in response to nitrogen limitation YP_002926980.1 MG1655 equivalent: b1990 YP_002926981.1 catalyzes the synthesis of alpha-ribazole-5'-phosphate from nicotinate mononucleotide and 5,6-dimethylbenzimidazole YP_002926982.1 catalyzes the formation of adenosylcobalamin from Ado-cobinamide-GDP and alpha-ribazole YP_002926983.1 catalyzes ATP-dependent phosphorylation of adenosylcobinamide to form adenosylcobinamide phosphate and the addition of guanosine monophosphate to adenosylcobinamide phosphate to form adenosylcobinamide-GDP YP_002926984.1 MG1655 equivalent: b1994 YP_002926985.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats YP_002926986.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats YP_002926987.1 MG1655 equivalent: b2000 YP_002926988.1 MG1655 equivalent: b2001 YP_002926989.1 MG1655 equivalent: b2002 YP_002926990.1 MG1655 equivalent: b2003 YP_002926991.1 MG1655 equivalent: b2004 YP_002926992.1 MG1655 equivalent: b2005 YP_002926993.1 MG1655 equivalent: b2007 YP_002926994.1 MG1655 equivalent: b2008 YP_002926995.1 MG1655 equivalent: b2009 YP_002926996.1 removes C-terminal D-alanyl residues from sugar-peptide cell wall precursors; penicillin-binding protein 6B; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_002926997.1 Exonucleolytic cleavage in the 3'- to 5'-direction to yield nucleoside 5'-phosphates YP_002926998.1 MG1655 equivalent: b2012 YP_002926999.1 MG1655 equivalent: b2013 YP_002927000.1 MG1655 equivalent: b2014 YP_002927001.1 MG1655 equivalent: b2015 YP_002927002.1 MG1655 equivalent: b2016 YP_002927003.1 MG1655 equivalent: b4539 YP_002927004.1 Antitoxin that counteracts the effect of the YoeB toxin YP_002927006.1 long form of enzyme; catalyzes the formation of N'-5'-phosphoribosyl-ATP from phosphoribosyl pyrophosphate; crucial role in histidine biosynthesis; forms active dimers and inactive hexamers which is dependent on concentration of substrates and inhibitors YP_002927007.1 catalyzes the oxidation of L-histidinol to L-histidinaldehyde and then to L-histidine in histidine biosynthesis; functions as a dimer YP_002927008.1 catalyzes the formation of L-histidinol phosphate from imidazole-acetol phosphate and glutamate in histidine biosynthesis YP_002927009.1 catalyzes the formation of 3-(imidazol-4-yl)-2-oxopropyl phosphate from D-ethythro-1-(imidazol-4-yl)glycerol 3-phosphate and histidinol from histidinol phosphate YP_002927010.1 with HisF IGPS catalyzes the conversion of phosphoribulosyl-formimino-5-aminoimidazole-4-carboxamide ribonucleotide phosphate and glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamide ribonucleotide, and glutamate in histidine biosynthesis; the HisH subunit provides the glutamine amidotransferase activity that produces the ammonia necessary to HisF for the synthesis of imidazole-glycerol phosphate and 5-aminoimidazol-4-carboxamide ribonucleotide YP_002927011.1 catalyzes the formation of 5-(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino-l- (5-phosphoribosyl)imidazole-4-carboxamide from 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide YP_002927012.1 catalyzes the conversion of 5-[(5-phospho-1-deoxyribulos-1-ylamino)methylideneamino]- 1-(5-phosphoribosyl)imidazole-4-carboxamideand glutamine to imidazole-glycerol phosphate, 5-aminoimidazol-4-carboxamideribonucleotide and glutamate; the HisF subunit acts as a cyclase YP_002927013.1 catalyzes the formation of 1-(5-phosphoribosyl)-AMP from 1-(5-phosphoribosyl)-ATP and the subsequent formation of 1-(5-phosphoribosyl)-5-((5- phosphoribosylamino)methylideneamino)imidazole-4- carboxamide from 1-(5-phosphoribosyl)-AMP in histidine biosynthesis YP_002927014.1 MG1655 equivalent: b2027 YP_002927015.1 MG1655 equivalent: b2028 YP_002927016.1 catalyzes the formation of D-ribulose 5-phosphate from 6-phospho-D-gluconate YP_002927017.1 MG1655 equivalent: b2030 YP_002927018.1 MG1655 equivalent: b2032 YP_002927019.1 WbbJ; catalyzes the transfer of the O-acetyl moiety to the O antigen; part of the lipopolysaccharide biosynthetic pathway YP_002927020.1 MG1655 equivalent: b2034 YP_002927021.1 MG1655 equivalent: b2035 YP_002927022.1 MG1655 equivalent: b2036 YP_002927023.1 MG1655 equivalent: b2037 YP_002927024.1 MG1655 equivalent: b2038 YP_002927025.1 MG1655 equivalent: b2039 YP_002927026.1 with dTDP-4-dehydrorhamnose 3,5-epimerase forms a complex known as dTDP-L-rhamnose synthetase; catalyzes the reduction of dTDP-4-dehydro-6-deoxy-L-mannose to dTDP-L-rhamnose YP_002927027.1 NAD(P) binding; catalyzes the formation of dTDP-4-dehydro-6-deoxy-D-glucose from dTDP-glucose YP_002927028.1 together with GalU subunit composes the UTP--glucose-1-phosphate uridylyltransferase, an enzyme that catalyzes the formation of UDP-glucose from UTP and alpha-D-glucose 1-phosphate; regulates cellular levels of UDP-glucose YP_002927029.1 WcaM from Salmonella enterica is essential for biofilm formation on HEp-2 cells and chicken intestinal tissue but not on a plastic surface; may be involved in the biosynthesis of colanic acid YP_002927030.1 MG1655 equivalent: b2044 YP_002927031.1 MG1655 equivalent: b2045 YP_002927032.1 MG1655 equivalent: b2046 YP_002927033.1 WcaJ; glucose-1-phosphate transferase responsible for the addition of the first glucose-1-phosphate from UDP-glucose to the lipid carrier undecaprenyl phosphate in the biosynthesis of colanic acid YP_002927034.1 MG1655 equivalent: b2048 YP_002927035.1 MG1655 equivalent: b2049 YP_002927036.1 MG1655 equivalent: b2050 YP_002927037.1 MG1655 equivalent: b2051 YP_002927038.1 MG1655 equivalent: b2052 YP_002927039.1 MG1655 equivalent: b2053 YP_002927040.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit) YP_002927041.1 MG1655 equivalent: b2055 YP_002927042.1 essential for colanic acid biosynthesis; colanic acid is an exopolysaccharide produced under stress conditions that confers acid and heat tolerance YP_002927043.1 MG1655 equivalent: b2057 YP_002927044.1 acetyltransferase believed to catalyze the addition of the acetyl group that is attached through an O linkage to the first fucosyl residue of the colanic acid repetitive unit (E unit); wcaB is induced in sessile bacteria and by osmotic shock, and repressed when grown in rich medium YP_002927045.1 MG1655 equivalent: b2059 YP_002927046.1 Wzc; catalyzes the autophosphorylation on tyrosine residues which downregulates the biosynthesis of colonic acid (an extracellular polysaccharide) YP_002927047.1 Wzb shows phosphatase activity towards the autophosphorylated Wzc protein, which induces colanic acid biosynthesis; catalyzes the phosphorylation of UDP-glucose dehydrogenase, an enzyme involved in colanic acid biosynthesis YP_002927048.1 MG1655 equivalent: b2062 YP_002927049.1 MG1655 equivalent: b2063 YP_002927050.1 YegA; inner membrane protein involved in the assembly of outer membrane proteins (OMPs); asmA-null mutants show low lipopolysaccharide (LPS) levels, suggesting a role in LPS biogenesis and/or in restricting outer membrane fluidity, resulting on altered assembly of OMPs YP_002927051.1 Catalyzes the formation of dUTP from dCTP in thymidylate biosynthesis YP_002927052.1 functions in pyrimidine salvage; pyrimidine ribonucleoside kinase; phosphorylates nucleosides or dinucleosides to make UMP or CMP using ATP or GTP as the donor YP_002927053.1 contains a MASE1 (Membrane-Associated Sensor) domain; potentially involved in signal transduction YP_002927054.1 inducible, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine, 3-methylguanine, 7-methylguanine and 7-methyladenine YP_002927055.1 MG1655 equivalent: b2069 YP_002927056.1 MG1655 equivalent: b2070 YP_002927057.1 MG1655 equivalent: b2071 YP_002927058.1 MG1655 equivalent: b2072 YP_002927059.1 MG1655 equivalent: b2073 YP_002927060.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_002927061.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC which confers resistance against novobiocin and deoxycholate YP_002927062.1 Part of a tripartite efflux system composed of MdtA, MdtB and MdtC; confers resistance against novobiocin and deoxycholate YP_002927063.1 MG1655 equivalent: b2077 YP_002927064.1 MG1655 equivalent: b2078 YP_002927065.1 response regulator in two-component regulatory system with BaeS; regulator of RNA synthesis, flagellar biosynthesis, chemotaxis and transport YP_002927066.1 MG1655 equivalent: b2080 YP_002927067.1 MG1655 equivalent: b2081 YP_002927068.1 in E. coli K-12 this is in prophage P2 remnant YP_002927069.1 MG1655 equivalent: b2085 YP_002927070.1 cytosolic protein with phosphatidylglycerol kinase activity; undetermined physiological role YP_002927071.1 MG1655 equivalent: b2088 YP_002927072.1 MG1655 equivalent: b2089 YP_002927073.1 Zn-dependent; NAD(P)-binding; catalyzes the formation of tagatose-6-phosphate from galactitol-1-phosphate YP_002927074.1 MG1655 equivalent: b2092 YP_002927075.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002927076.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002927077.1 MG1655 equivalent: b2095 YP_002927078.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway YP_002927079.1 catalyzes the formation of glycerone phosphate and D-glyceraldehyde 3-phosphate from D-fructose 1,6-bisphosphate YP_002927080.1 MG1655 equivalent: b2098 YP_002927081.1 MG1655 equivalent: b2099 YP_002927082.1 MG1655 equivalent: b2100 YP_002927083.1 MG1655 equivalent: b2101 YP_002927084.1 MG1655 equivalent: b2102 YP_002927085.1 catalyzes the formation of 4-amino-2-methyl-5-diphosphomethylpyrimidine YP_002927086.1 catalyzes the formation of 4-methyl-5-(2-phosphoethyl)-thiazole and ADP from 4-methyl-5-(2-hydroxyethyl)-thiazole and ATP YP_002927087.1 MG1655 equivalent: b2105 YP_002927088.1 membrane protein conferring nickel and cobalt resistance YP_002927089.1 MG1655 equivalent: b2107 YP_002927090.1 MG1655 equivalent: b2108 YP_002927091.1 MG1655 equivalent: b2109 YP_002927092.1 MG1655 equivalent: b2110 YP_002927093.1 MG1655 equivalent: b2111 YP_002927094.1 MG1655 equivalent: b2112 YP_002927095.1 MG1655 equivalent: b2113 YP_002927096.1 methionine--tRNA ligase; MetRS; adds methionine to tRNA(Met) with cleavage of ATP to AMP and diphosphate; some MetRS enzymes form dimers depending on a C-terminal domain that is also found in other proteins such as Trbp111 in Aquifex aeolicus and the cold-shock protein CsaA from Bacillus subtilis while others do not; four subfamilies exist based on sequence motifs and zinc content YP_002927097.1 MG1655 equivalent: b2118 YP_002927098.1 MG1655 equivalent: b4541 YP_002927099.1 MG1655 equivalent: b2119 YP_002927100.1 MG1655 equivalent: b2120 YP_002927101.1 MG1655 equivalent: b2121 YP_002927102.1 MG1655 equivalent: b2123 YP_002927103.1 MG1655 equivalent: b2124 YP_002927104.1 unknown function; when overproduced it confers drug-resistance YP_002927105.1 MG1655 equivalent: b2126 YP_002927106.1 MG1655 equivalent: b2127 YP_002927107.1 MG1655 equivalent: b4542 YP_002927108.1 MG1655 equivalent: b2128 YP_002927109.1 MG1655 equivalent: b2129 YP_002927110.1 MG1655 equivalent: b2130 YP_002927111.1 MG1655 equivalent: b2131 YP_002927112.1 MG1655 equivalent: b2132 YP_002927113.1 component of the membrane-bound D-lactate oxidase, FAD-binding, NADH independent YP_002927114.1 specifically hydrolyze the DD-diaminopimelate-alanine bonds in high-molecular-mass murein sacculi; Penicillin-binding protein 7 YP_002927115.1 MG1655 equivalent: b2135 YP_002927116.1 MG1655 equivalent: b2136 YP_002927117.1 MG1655 equivalent: b2137 YP_002927118.1 MG1655 equivalent: b2140 YP_002927119.1 MG1655 equivalent: b2141 YP_002927120.1 MG1655 equivalent: b2142 YP_002927121.1 Reclaims exogenous and endogenous cytidine and 2'-deoxycytidine molecules for UMP synthesis YP_002927122.1 MG1655 equivalent: b2144 YP_002927123.1 MG1655 equivalent: b2145 YP_002927124.1 function undetermined; similar to glutamate synthase beta subunit and related oxidoreductases which transfer electrons from NADPH to an acceptor protein or protein domain YP_002927125.1 catalyzes the first step in pyrimidine degradation: the NADPH-dependent reduction of uracil and thymine to the corresponding 5,6-dihydropyrimidines YP_002927126.1 ABC transporter; functions in galactose transport; part of MglA2C2B transporter complex YP_002927127.1 with MglBC transports galactose or methyl galactoside into the cell; contains 2 ATP binding domains YP_002927128.1 MG1655 equivalent: b2150 YP_002927129.1 negative regulator of the mglBAC operon for galactose utilization YP_002927130.1 MG1655 equivalent: b2152 YP_002927131.1 involved in the first step of tetrahydrofolate biosynthesis; catalyzes the formation of formate and 2-amino-4-hydroxy-6-(erythro-1,2, 3-trihydroxypropyl)dihydropteridine triphosphate from GTP and water; forms a homopolymer YP_002927132.1 MG1655 equivalent: b2154 YP_002927133.1 Cir; FeuA; CirA; receptor protein for siderophores (colicin IA, IB and V) and microcins (E492, H47, and M); TonB-dependent; able to transport monomers, dimer, and linear trimers of 2,3-dihydorxybenzoylserine; outer membrane protein YP_002927134.1 MG1655 equivalent: b2156 YP_002927135.1 MG1655 equivalent: b2157 YP_002927136.1 MG1655 equivalent: b2158 YP_002927137.1 Assists in DNA repair by cleaving phosphodiester bonds at apurinic or apyrimidinic sties to produce new 5' ends that are base-free deoxyribose 5-phosphate residues YP_002927138.1 MG1655 equivalent: b2160 YP_002927139.1 MG1655 equivalent: b2161 YP_002927140.1 Hydrolyzes cytidine or uridine to ribose and cytosine or uracil, respectively YP_002927141.1 activator of nucleoside metabolism YP_002927142.1 MG1655 equivalent: b2164 YP_002927143.1 MG1655 equivalent: b2165 YP_002927144.1 MG1655 equivalent: b2166 YP_002927145.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002927146.1 MG1655 equivalent: b2168 YP_002927147.1 MG1655 equivalent: b2174 YP_002927148.1 by similarity, Spr seems to have peptidase activity; involved in thermoresistance YP_002927149.1 MG1655 equivalent: b2176 YP_002927150.1 MG1655 equivalent: b2177 YP_002927151.1 MG1655 equivalent: b2178 YP_002927152.1 MG1655 equivalent: b2179 YP_002927153.1 MG1655 equivalent: b2180 YP_002927154.1 MG1655 equivalent: b2181 YP_002927155.1 Involved in sulfonamide (sulfathiazole) and bicyclomycin resistance YP_002927156.1 catalyzes the synthesis pseudouridine from uracil-516 in 16S ribosomal RNA YP_002927157.1 MG1655 equivalent: b2184 YP_002927158.1 the Ctc family of proteins consists of two types, one that contains the N-terminal ribosomal protein L25 domain only which in Escherichia coli binds the 5S rRNA while a subset of proteins contain a C-terminal extension that is involved in the stress response YP_002927159.1 MG1655 equivalent: b2186 YP_002927160.1 MG1655 equivalent: b2187 YP_002927161.1 MG1655 equivalent: b2188 YP_002927162.1 MG1655 equivalent: b2192 YP_002927163.1 nitrate/nitrite response regulator NarP; NarP is phosphorylated by NarX and NarQ and can activate fdnG and nitrite or nitrate reductase systems; represses expression of other anaerobic genes YP_002927164.1 MG1655 equivalent: b2194 YP_002927165.1 MG1655 equivalent: b2195 YP_002927166.1 MG1655 equivalent: b2196 YP_002927167.1 CycJ; periplasmic heme chaperone that binds heme transiently via a histidine residue and delivers it to newly synthesized and exported c-type cytochromes; requires the ATP hydrolysis activity of the CcmA protein in order to transfer the heme to the apocytochrome; part of the cytochrome c maturation system; periplasmic protein anchored to the inner membrane YP_002927168.1 MG1655 equivalent: b2198 YP_002927169.1 MG1655 equivalent: b2199 YP_002927170.1 MG1655 equivalent: b2200 YP_002927171.1 ATP-binding protein; required for proper cytochrome c maturation YP_002927172.1 with NapABDFGH functions as a nitrate reductase; NapC functions as an electron shuttle between NapAB and NapGH or quinone YP_002927173.1 small subunit of periplasmic nitrate reductase; receives electrons from the membrane-bound NapC and passes them to NapA YP_002927174.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA YP_002927175.1 part of NapHG quinol dehydrogenase; couples electron transfer from ubiquinone-ubiquinol couple via NapC/B to NapA; secreted by twin arginine translocation pathway YP_002927176.1 periplasmic; catalytic subunit; with NapBC catalyzes the reduction of nitrate to nitrite; NapAB receives electrons from NapC YP_002927177.1 MG1655 equivalent: b2207 YP_002927178.1 Predicted role in electron transfer to the periplasmic nitrate reductase protein NapA. YP_002927179.1 MG1655 equivalent: b4604 YP_002927180.1 serine protease inhibitor, inhibits trypsin and other proteases YP_002927181.1 malate dehydrogenase; catalyzes the oxidation of malate to oxaloacetate YP_002927182.1 efflux pump for the antibacterial peptide microcin J25 YP_002927183.1 MG1655 equivalent: b2212 YP_002927184.1 MG1655 equivalent: b2213 YP_002927185.1 catalyzes the conversion of aminoimidazole ribotide to the 4-amino-5-hydroxymethyl-2-methyl pyrimidine moiety of thiamine; involved in the maintenance and/or assembly of sulfur clusters; periplasmic lipoporotein anchored to the inner membrane; part of the thiamine pyrophosphate biosynthesis pathway YP_002927186.1 allows for ions and hydrophilic solutes to cross the outer membrane YP_002927187.1 MG1655 equivalent: b2216 YP_002927188.1 two-component response regulator RscB regulates the genes involved in capsule biosynthesis and cell division; probably phosphorylated by RcsC or RcsF YP_002927189.1 MG1655 equivalent: b2218 YP_002927190.1 with AtoC is a member of a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism YP_002927191.1 with AtoS is a two-component regulatory system involved in the transcriptional regulation of the ato genes for acetoacetate metabolism YP_002927192.1 MG1655 equivalent: b2221 YP_002927193.1 MG1655 equivalent: b2222 YP_002927194.1 MG1655 equivalent: b2223 YP_002927195.1 MG1655 equivalent: b2224 YP_002927196.1 MG1655 equivalent: b2225 YP_002927197.1 MG1655 equivalent: b2226 YP_002927198.1 MG1655 equivalent: b2229 YP_002927199.1 MG1655 equivalent: b2230 YP_002927200.1 negatively supercoils closed circular double-stranded DNA YP_002927201.1 Involved in ubiquinone biosynthesis YP_002927202.1 MG1655 equivalent: b2233 YP_002927203.1 MG1655 equivalent: b4605 YP_002927204.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002927205.1 B2 or R2 protein; type 1a enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdA YP_002927206.1 plays a role in maintenance and possibly the biosynthesis of diferric-tyrosyl radical cofactor, essential for nucleotide reduction catalyzed by ribonucleotide reductases YP_002927207.1 MG1655 equivalent: b2237 YP_002927208.1 hydrolyzes deacylated phospholipids to glycerol 3-phosphate and the corresponding alcohols; periplasmic YP_002927209.1 catalyzes the uptake of glycerol-3-phosphate into the cell with the simultaneous export of inorganic phosphate from the cell YP_002927210.1 anaerobic, catalyzes the conversion of glycerol 3-phosphate to dihydroxyacetone using fumarate or nitrate as electron acceptor YP_002927211.1 sn-glycerol-3-phosphate dehydrogenase (anaerobic); catalyzes the formation of dihydroxyacetone from glycerol 3-phosphate; part of GlpABC complex; presumably this subunit is responsible for membrane interactions and contains iron-sulfur clusters YP_002927212.1 anaerobic; with GlpAB catalyzes the conversion of glycerol-3-phosphate to dihydroxyacetone phosphate YP_002927213.1 MG1655 equivalent: b2244 YP_002927214.1 MG1655 equivalent: b4543 YP_002927215.1 MG1655 equivalent: b2245 YP_002927216.1 MG1655 equivalent: b2246 YP_002927217.1 MG1655 equivalent: b2247 YP_002927218.1 MG1655 equivalent: b2248 YP_002927219.1 MG1655 equivalent: b2249 YP_002927220.1 MG1655 equivalent: b2250 YP_002927221.1 MG1655 equivalent: b2251 YP_002927222.1 MG1655 equivalent: b2252 YP_002927223.1 catalyzes the conversion of UDP-4-keto-arabinose to UDP-4-amino-4-deoxy-L-arabinose YP_002927224.1 catalyzes the transfer of 4-deoxy-4-formamido-L-arabinose from UDP to undecaprenyl phosphate YP_002927225.1 Bifunctional polymyxin resistance arnA protein; catalyzes the decarboxylation of UDP-glucuronic acid to UDP-4-keto-arabinose and the addition of a formyl group to UDP-4-amino-4-deoxy-L-arabinose to form UDP-L-4-formamido-arabinose; active in certain mutant strains YP_002927226.1 MG1655 equivalent: b2256 YP_002927227.1 catalyzes the addition of 4-amino-4-deoxy-L-arabinose to lipid A YP_002927228.1 MG1655 equivalent: b4544 YP_002927229.1 MG1655 equivalent: b2258 YP_002927230.1 MG1655 equivalent: b2259 YP_002927231.1 MG1655 equivalent: b2260 YP_002927232.1 catalyzes the dehydration of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylic acid to form O-succinylbenzoate YP_002927233.1 catalyzes the formation of 1,4-dihydroxy-2-naphthoate from O-succinylbenzoyl-CoA YP_002927234.1 catalyzes the hydrolysis of the thioester bond in palmitoyl-CoA YP_002927235.1 SEPHCHC synthase; forms 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1- carboxylate from 2-oxoglutarate and isochorismate in menaquinone biosynthesis YP_002927236.1 MG1655 equivalent: b2265 YP_002927237.1 MG1655 equivalent: b2266 YP_002927238.1 MG1655 equivalent: b2267 YP_002927239.1 member of metallo-beta-lactamase family; the purified enzyme from Escherichia coli forms dimeric zinc phosphodiesterase; in Bacillus subtilis this protein is a 3'-tRNA processing endoribonuclease and is essential while in Escherichia coli it is not; associates with two zinc ions YP_002927240.1 ElaD; specific cysteine protease which targets ubiquitin and ubiquitin-like proteins covalently bound to target proteins; SseL in Salmonella is required for macrophage killing and virulence, and it is secreted by the salmonella pathogenicity island 2 type III secretion system YP_002927241.1 MG1655 equivalent: b2270 YP_002927242.1 MG1655 equivalent: b2271 YP_002927243.1 MG1655 equivalent: b2272 YP_002927244.1 MG1655 equivalent: b2273 YP_002927245.1 MG1655 equivalent: b2274 YP_002927246.1 MG1655 equivalent: b2275 YP_002927247.1 Catalyzes the transfer of electrons from NADH to quinone YP_002927248.1 Catalyzes the transfer of electrons from NADH to quinone YP_002927249.1 Catalyzes the transfer of electrons from NADH to ubiquinone YP_002927250.1 Catalyzes the transfer of electrons from NADH to quinone YP_002927251.1 Catalyzes the transfer of electrons from NADH to quinone YP_002927252.1 Catalyzes the transfer of electrons from NADH to quinone YP_002927253.1 Catalyzes the transfer of electrons from NADH to quinone YP_002927254.1 Catalyzes the transfer of electrons from NADH to quinone YP_002927255.1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; NuoF is part of the soluble NADH dehydrogenase fragment, which represents the electron input part of NADH dehydrogenase YP_002927256.1 Catalyzes the transfer of electrons from NADH to quinone YP_002927257.1 NuoCD; NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain; subunits NuoCD, E, F, and G constitute the peripheral sector of the complex; in Escherichia coli this gene encodes a fusion protein of NuoC and NuoD that are found separate in other organisms YP_002927258.1 The point of entry for the majority of electrons that traverse the respiratory chain eventually resulting in the reduction of oxygen YP_002927259.1 Catalyzes the transfer of electrons from NADH to quinone YP_002927260.1 MG1655 equivalent: b2289 YP_002927261.1 broad specificity; family IV; in Corynebacterium glutamicum this protein can use glutamate, 2-aminobutyrate, and aspartate as amino donors and pyruvate as the acceptor YP_002927262.1 MG1655 equivalent: b2291 YP_002927263.1 MG1655 equivalent: b2292 YP_002927264.1 MG1655 equivalent: b2293 YP_002927265.1 MG1655 equivalent: b2294 YP_002927266.1 MG1655 equivalent: b2295 YP_002927267.1 AckA utilizes acetate and can acetylate CheY which increases signal strength during flagellar rotation; utilizes magnesium and ATP; also involved in conversion of acetate to aceyl-CoA YP_002927268.1 catalyzes the synthesis of acetylphosphate or propionylphosphate from acetyl-CoA or propionyl-CoA and inorganic phosphate; when using propionyl-CoA the enzyme is functioning in the anaerobic pathway catabolizing threonine to propionate YP_002927269.1 MG1655 equivalent: b2298 YP_002927270.1 MG1655 equivalent: b2299 YP_002927271.1 MG1655 equivalent: b2300 YP_002927272.1 MG1655 equivalent: b2301 YP_002927273.1 MG1655 equivalent: b2302 YP_002927274.1 catalyzes the formation of dihydromonapterin triphosphate from dihydroneopterin triphosphate YP_002927275.1 MG1655 equivalent: b2304 YP_002927276.1 MG1655 equivalent: b2305 YP_002927277.1 MG1655 equivalent: b2306 YP_002927278.1 MG1655 equivalent: b2307 YP_002927279.1 MG1655 equivalent: b2308 YP_002927280.1 MG1655 equivalent: b2309 YP_002927281.1 MG1655 equivalent: b2310 YP_002927282.1 catalyzes the formation of 2-octaprenylphenol from 3-octaprenyl-4-hydroxybenzoate YP_002927283.1 Catalyzes first step of the de novo purine nucleotide biosynthetic pathway YP_002927284.1 membrane protein required for colicin V production YP_002927285.1 MG1655 equivalent: b2314 YP_002927286.1 MG1655 equivalent: b2315 YP_002927287.1 catalyzes the carboxylation of acetyl-CoA to malonyl-CoA; forms a tetramer of AccA2D2 subunits YP_002927288.1 MG1655 equivalent: b2317 YP_002927289.1 mediates pseudouridylation (positions 38, 39, 40) at the tRNA anticodon region which contributes to the structural stability YP_002927290.1 MG1655 equivalent: b2319 YP_002927291.1 MG1655 equivalent: b2320 YP_002927292.1 in Salmonella typhimurium Flk regulates flagellar biosynthesis by inhibition of the flagellar-associated type III secretion system; lowers secretion levels of the anti-sigma28 factor FlgM to the periplasm; inner membrane-anchored protein YP_002927293.1 MG1655 equivalent: b2322 YP_002927294.1 FabB, beta-Ketoacyl-ACP synthase I, KASI; catalyzes a condensation reaction in fatty acid biosynthesis: addition of an acyl acceptor of two carbons from malonyl-ACP; required for the elongation of short-chain unsaturated acyl-ACP YP_002927295.1 catalyzes the formation of 5-methylaminomethyl-2-thiouridine in position 34 of the anticodon of tRNA molecules YP_002927296.1 MG1655 equivalent: b2325 YP_002927297.1 MG1655 equivalent: b2326 YP_002927298.1 MG1655 equivalent: b2327 YP_002927299.1 D-alanyl-D-alanine endopeptidase; functions in hydrolyzing cell wall peptidoglycan; similar to LAS metallopeptidases; forms a dimer in periplasm YP_002927300.1 catalyzes the formation of chorismate from 5-O-(1-carboxyvinyl)-3-phosphoshikimate in aromatic amino acid biosynthesis YP_002927301.1 involved in methylation of ribosomal protein L3 YP_002927302.1 MG1655 equivalent: b2331 YP_002927303.1 MG1655 equivalent: b2332 YP_002927304.1 MG1655 equivalent: b2333 YP_002927305.1 MG1655 equivalent: b2334 YP_002927306.1 MG1655 equivalent: b2335 YP_002927307.1 MG1655 equivalent: b2336 YP_002927308.1 MG1655 equivalent: b2339 YP_002927309.1 MG1655 equivalent: b2340 YP_002927310.1 multifunctional enoyl-CoA hydratase/3-hydroxyacyl-CoA dehydrogenase/3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities: forms a heterotetramer with FadI; similar to FadA2B2 complex; involved in the anaerobic degradation of long and medium-chain fatty acids in the presence of nitrate YP_002927311.1 FadI; fatty acid oxidation complex component beta; functions in a heterotetramer with FadJ; similar to FadA2B2 complex; functions in beta-oxidation of fatty acids during anaerobic growth YP_002927312.1 MG1655 equivalent: b2343 YP_002927313.1 MG1655 equivalent: b2344 YP_002927314.1 MG1655 equivalent: b2345 YP_002927315.1 MG1655 equivalent: b2346 YP_002927316.1 MG1655 equivalent: b2347 YP_002927317.1 MG1655 equivalent: b2349 YP_002927318.1 MG1655 equivalent: b2350 YP_002927319.1 MG1655 equivalent: b2351 YP_002927320.1 MG1655 equivalent: b2352 YP_002927321.1 MG1655 equivalent: b2354 YP_002927322.1 MG1655 equivalent: b2357 YP_002927323.1 MG1655 equivalent: b2359 YP_002927324.1 MG1655 equivalent: b2360 YP_002927325.1 MG1655 equivalent: b2361 YP_002927326.1 MG1655 equivalent: b2362 YP_002927327.1 MG1655 equivalent: b2363 YP_002927328.1 MG1655 equivalent: b4501 YP_002927329.1 regulates the synthesis and expression of the dsdXA operon and dadA gene YP_002927330.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function YP_002927331.1 catalyzes the formation of pyruvate from serine YP_002927332.1 MG1655 equivalent: b2367 YP_002927333.1 MG1655 equivalent: b2368 YP_002927334.1 response regulator in two-component regulatory system with EvgS; phosphorylated EvgA activates ompC, emrKY, gadABC, hdeAB and others genes; involved in acid resistance, osmotic adaption, and drug resistance YP_002927335.1 MG1655 equivalent: b2370 YP_002927336.1 MG1655 equivalent: b2371 YP_002927337.1 member of the AEC family of auxin efflux transporters; unknown function YP_002927338.1 catalyzes the formation of formyl-CoA from oxalyl-CoA YP_002927339.1 catalyzes the formation of oxalyl-CoA from oxalate and Formyl-CoA YP_002927340.1 MG1655 equivalent: b2375 YP_002927341.1 MG1655 equivalent: b2376 YP_002927342.1 MG1655 equivalent: b2377 YP_002927343.1 Acylates the intermediate (KDO)2-lipid IVA to form (KDO)2-(palmitoleoyl)-lipid IVA in cells subjected to cold shock YP_002927344.1 MG1655 equivalent: b2379 YP_002927345.1 MG1655 equivalent: b2380 YP_002927346.1 MG1655 equivalent: b2381 YP_002927347.1 MG1655 equivalent: b2382 YP_002927348.1 MG1655 equivalent: b2383 YP_002927349.1 metalloprotein YP_002927350.1 Xaa-Pro aminopeptidase; limited methionine aminopeptidase YP_002927351.1 MG1655 equivalent: b2386 YP_002927352.1 MG1655 equivalent: b2387 YP_002927353.1 catalyzes the conversion of ATP and D-glucose to ADP and D-glucose 6-phosphate YP_002927354.1 MG1655 equivalent: b2389 YP_002927355.1 MG1655 equivalent: b2390 YP_002927356.1 MG1655 equivalent: b2392 YP_002927357.1 MG1655 equivalent: b2393 YP_002927358.1 MG1655 equivalent: b2394 YP_002927359.1 MG1655 equivalent: b2395 YP_002927360.1 MG1655 equivalent: b2398 YP_002927361.1 MG1655 equivalent: b2399 YP_002927362.1 Charges one glutamine molecule and pairs it to its corresponding RNA trinucleotide during protein translation YP_002927363.1 MG1655 equivalent: b2405 YP_002927364.1 MG1655 equivalent: b2406 YP_002927365.1 catalyzes the formation of a purine and ribose phosphate from a purine nucleoside; in E. coli this enzyme functions in xanthosine degradation YP_002927366.1 MG1655 equivalent: b2408 YP_002927367.1 MG1655 equivalent: b2409 YP_002927368.1 MG1655 equivalent: b2410 YP_002927369.1 MG1655 equivalent: b4546 YP_002927370.1 this protein catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction; essential for DNA replication and repair of damaged DNA; similar to ligase LigB YP_002927371.1 interacts with cell division protein FitsZ and may be required to anchor septal ring structure YP_002927372.1 putative role in sulfur assimilation YP_002927373.1 CysK; forms a complex with serine acetyltransferase CysE; functions in cysteine biosynthesis YP_002927374.1 MG1655 equivalent: b2415 YP_002927375.1 Phosphotransferase system, enzyme I; transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein; part of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active-transport system YP_002927376.1 functions in phosphoenolpyruvate-(PEP)-dependent phosphotransferase (PTS) system; functions in the transport and phosphorylation of glucose YP_002927377.1 catalyzes the formation of pyridoxal 5'-phosphate from pyridoxal YP_002927378.1 MG1655 equivalent: b2419 YP_002927379.1 MG1655 equivalent: b2420 YP_002927380.1 catalyzes the formation of cysteine from 3-O-acetyl-L-serine and hydrogen sulfide YP_002927381.1 MG1655 equivalent: b2422 YP_002927382.1 Part of the ABC transporter complex cysAWTP involved in sulfate/thiosulfate import YP_002927383.1 MG1655 equivalent: b2424 YP_002927384.1 MG1655 equivalent: b2425 YP_002927385.1 MG1655 equivalent: b2426 YP_002927386.1 MG1655 equivalent: b2427 YP_002927387.1 catalyzes the cleavage of the lactyl ether moiety of N-acetylmuramic acid-6-phosphate (MurNAc-6-P) to form N-acetylglucosamine-6-phosphate (GlcNAc-6-P) and lactate; involved in MurNAc dissimilation pathway YP_002927388.1 belongs to PEP-dependent PTS system; contains the PTS EIIBC domains; involved in uptake of exogenous N-acetylmuramic acid (MurNAc); requires crr-encoded enzyme IIA-glucose component YP_002927389.1 MG1655 equivalent: b2430 YP_002927390.1 MG1655 equivalent: b2431 YP_002927391.1 MG1655 equivalent: b2432 YP_002927392.1 MG1655 equivalent: b2433 YP_002927393.1 MG1655 equivalent: b2434 YP_002927394.1 MG1655 equivalent: b2435 YP_002927395.1 catalyzes the conversion of the propionic acid groups of rings I and III to vinyl groups during heme synthesis YP_002927396.1 activates the transcription of the ethanolamine utilization operon YP_002927397.1 MG1655 equivalent: b2438 YP_002927398.1 MG1655 equivalent: b2439 YP_002927399.1 catalyzes the formation of acetaldehyde from ethanolamine YP_002927400.1 MG1655 equivalent: b2441 YP_002927401.1 MG1655 equivalent: b2442 YP_002927402.1 MG1655 equivalent: b2443 YP_002927403.1 MG1655 equivalent: b2444 YP_002927404.1 MG1655 equivalent: b2445 YP_002927405.1 MG1655 equivalent: b2446 YP_002927406.1 MG1655 equivalent: b2447 YP_002927407.1 MG1655 equivalent: b2448 YP_002927408.1 MG1655 equivalent: b2449 YP_002927409.1 MG1655 equivalent: b2450 YP_002927410.1 ethanolamine utilization protein EutA YP_002927411.1 MG1655 equivalent: b2452 YP_002927412.1 MG1655 equivalent: b2453 YP_002927413.1 MG1655 equivalent: b2454 YP_002927414.1 MG1655 equivalent: b2455 YP_002927415.1 MG1655 equivalent: b2456 YP_002927416.1 MG1655 equivalent: b2457 YP_002927417.1 in Salmonella this enzyme is required for ethanolamine catabolism; has higher affinity for CoA than Pta YP_002927418.1 MG1655 equivalent: b2459 YP_002927419.1 MG1655 equivalent: b2460 YP_002927420.1 MG1655 equivalent: b2461 YP_002927421.1 MG1655 equivalent: b2462 YP_002927422.1 NADP-dependent; catalyzes the oxidative decarboxylation of malate to form pyruvate; decarboxylates oxaloacetate YP_002927423.1 MG1655 equivalent: b2464 YP_002927424.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_002927425.1 MG1655 equivalent: b2466 YP_002927426.1 MG1655 equivalent: b2467 YP_002927427.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic) YP_002927428.1 MG1655 equivalent: b2469 YP_002927429.1 MG1655 equivalent: b2470 YP_002927431.1 MG1655 equivalent: b2471 YP_002927432.1 dapE-encoded N-succinyl-L,L-diaminopimelic acid desuccinylase (DapE), catalyzes the hydrolysis of N-succinyl-L,Ldiaminopimelate L,L-SDAP to L,L-diaminopimelate and succinate. It is a metalloprotease containing dinuclear active sites. Its structure is similar to the carboxypeptidase G2 from Pseudomonas sp. strain RS-16 and the aminopeptidase from Aeromonas proteolytica. YP_002927433.1 MG1655 equivalent: b4547 YP_002927434.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_002927435.1 MG1655 equivalent: b2474 YP_002927436.1 MG1655 equivalent: b2475 YP_002927437.1 catalyzes the formation of (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4- carboxamido)succinate from 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate and L-aspartate in purine biosynthesis; SAICAR synthase YP_002927438.1 MG1655 equivalent: b2477 YP_002927439.1 catalyzes the formation of dihydrodipicolinate from L-aspartate 4-semialdehyde and pyruvate in lysine and diaminopimelate biosynthesis YP_002927440.1 negative transcriptional regulator of the gcvTHP operon YP_002927441.1 bacterioferritin comigratory protein; thiol peroxidase; thioredoxin-dependent; hydroperoxide peroxidase; in Escherichia coli this enzyme preferentially reduces linoleic acid hydroperoxide; contains an active site cysteine YP_002927442.1 MG1655 equivalent: b2481 YP_002927443.1 MG1655 equivalent: b2482 YP_002927444.1 MG1655 equivalent: b2483 YP_002927445.1 MG1655 equivalent: b2484 YP_002927446.1 interacts with formate dehydrogenase to produce an active formate hydrogenlyase complex which cleaves formate to dihydrogen and carbon dioxide YP_002927447.1 MG1655 equivalent: b2486 YP_002927448.1 MG1655 equivalent: b2487 YP_002927449.1 probable electron transfer protein for hydrogenase 4; hydrogenase 4 is believed to be silent in E. coli under conditions tested so far YP_002927450.1 MG1655 equivalent: b2489 YP_002927451.1 MG1655 equivalent: b2490 YP_002927452.1 MG1655 equivalent: b2491 YP_002927453.1 inner membrane protein presumed to act as a formate transporter; member of the hyf operon YP_002927454.1 MG1655 equivalent: b2493 YP_002927455.1 MG1655 equivalent: b2494 YP_002927456.1 MG1655 equivalent: b2495 YP_002927457.1 controls initiation of DNA replication by inhibiting re-initiation of replication, promotes hydrolysis of DnaA-bound ATP YP_002927458.1 MG1655 equivalent: b2497 YP_002927459.1 Catalyzes the formation of uracil and 5-phospho-alpha-D-ribosy 1-diphosphate from UMP and diphosphate YP_002927460.1 catalyzes the formation of 1-(5-phosphoribosyl)-5-aminoimidazole from 2-(formamido)-N1-(5-phosphoribosyl)acetamidine and ATP in purine biosynthesis YP_002927461.1 glycinamide ribonucleotide transformylase; GAR Tfase; catalyzes the synthesis of 5'-phosphoribosylformylglycinamide from 5'-phosphoribosylglycinamide and 10-formyltetrahydrofolate; PurN requires formyl folate for the reaction unlike PurT which uses formate YP_002927462.1 catalyzes the reversible transfer of the terminal phosphate of ATP to form a long chain polyphosphate YP_002927463.1 MG1655 equivalent: b2502 YP_002927464.1 MG1655 equivalent: b2503 YP_002927465.1 MG1655 equivalent: b2504 YP_002927466.1 MG1655 equivalent: b2505 YP_002927467.1 MG1655 equivalent: b2506 YP_002927468.1 contains glutamine-hydrolyzing domain and glutamine amidotransferase; GMP-binding domain; functions to produce GMP from XMP in the IMP pathway YP_002927469.1 catalyzes the synthesis of xanthosine monophosphate by the NAD+ dependent oxidation of inosine monophosphate YP_002927470.1 bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides YP_002927471.1 MG1655 equivalent: b2510 YP_002927472.1 EngA; essential Neisserial GTPase; synchronizes cellular events by interacting with multiple targets with tandem G-domains; overexpression in Escherichia coli suppresses rrmJ mutation; structural analysis of the Thermotoga maritima ortholog shows different nucleotide binding affinities in the two binding domains YP_002927473.1 with YaeT, YfiO, and NlpB forms a complex involved in outer membrane protein biogenesis YP_002927474.1 MG1655 equivalent: b2513 YP_002927475.1 catalyzes a two-step reaction, first charging a histidine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; class II aminoacyl-tRNA synthetase; forms homodimers; some organisms have a paralogous gene, hisZ, that is similar to hisS and produces a protein that performs the first step in histidine biosynthesis along with HisG YP_002927476.1 catalyzes the conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate into 4-hydroxy-3-methyl-2-en-1-yl diphosphate; involved in isoprenoid synthesis YP_002927477.1 MG1655 equivalent: b2516 YP_002927478.1 23S rRNA m2A2503 methyltransferase; methylates the C2 position of the A2530 nucleotide in 23S rRNA; may be involved in antibiotic resistance YP_002927479.1 catalyzes the formation of nucleoside triphosphate from ATP and nucleoside diphosphate YP_002927480.1 penicillin-insensitive transglycosylase/transpeptidase YP_002927481.1 MG1655 equivalent: b2520 YP_002927482.1 catalyzes the transfer of a sulfur ion to cyanide or to other thiol compounds YP_002927483.1 enhances serine sensitivity caused by inhibition of homoserine dehydrogenase I YP_002927484.1 catalyzes the removal of an N-terminal amino acid from a peptide or arylamide YP_002927485.1 MG1655 equivalent: b2524 YP_002927486.1 MG1655 equivalent: b2525 YP_002927487.1 involved in the maturation of iron-sulfur cluster-containing proteins YP_002927488.1 J-type co-chaperone that regulates the ATPase and peptide-binding activity of Hsc66 chaperone; may function in biogenesis of iron-sulfur proteins YP_002927489.1 forms iron-sulfur clusters of ferredoxin [2FE-2S]; binds iron in the presence of the thioredoxin reductase system; forms homodimers and tetramers; similar to SufA protein YP_002927490.1 MG1655 equivalent: b2529 YP_002927491.1 catalyzes the removal of elemental sulfur from cysteine to produce alanine; involved in NAD biosynthesis YP_002927492.1 regulates the expression of the iscRSUA operon YP_002927493.1 MG1655 equivalent: b2532 YP_002927494.1 MG1655 equivalent: b2533 YP_002927495.1 MG1655 equivalent: b2534 YP_002927496.1 MG1655 equivalent: b2535 YP_002927497.1 putative transporter of 3-phenylpropionate across the inner membrane; member of the major facilitator superfamily of transporters YP_002927498.1 activator of 3-phenylpropionic acid catabolism YP_002927499.1 MG1655 equivalent: b2538 YP_002927500.1 MG1655 equivalent: b2539 YP_002927501.1 MG1655 equivalent: b2540 YP_002927502.1 Converts cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol) into 3-(2,3-dihydroxylphenyl)propionate YP_002927503.1 MG1655 equivalent: b2542 YP_002927504.1 MG1655 equivalent: b2543 YP_002927505.1 MG1655 equivalent: b2544 YP_002927506.1 MG1655 equivalent: b2545 YP_002927507.1 MG1655 equivalent: b2546 YP_002927508.1 MG1655 equivalent: b2547 YP_002927509.1 MG1655 equivalent: b2548 YP_002927510.1 MG1655 equivalent: b2549 YP_002927511.1 MG1655 equivalent: b2550 YP_002927512.1 catalyzes the reaction of glycine with 5,10-methylenetetrahydrofolate to form L-serine and tetrahydrofolate YP_002927513.1 flavohemoprotein; catalyzes the formation of nitrate from nitric oxide; can also catalyze the reduction of dihydropteridine YP_002927514.1 indirectly regulates nitrogen metabolism; at high nitrogen levels P-II prevents the phosphorylation of NR-I, the transcriptional activator of the glutamine synthetase gene (glnA); at low nitrogen levels P-II is uridylylated to form PII-UMP and interacts with an adenylyltransferase (GlnE) that activates GlnA YP_002927515.1 MG1655 equivalent: b2554 YP_002927516.1 MG1655 equivalent: b2555 YP_002927517.1 MG1655 equivalent: b2556 YP_002927518.1 catalyzes the formation of 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine from N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide and L-glutamine in purine biosynthesis YP_002927519.1 YfhD; uncharacterized member of the transglycosylase slt family; part of the rob operon, which plays a role in cellular resistance to antibiotics, bactericidal agents, and organic solvents; unknown function YP_002927520.1 MG1655 equivalent: b2559 YP_002927521.1 MG1655 equivalent: b2560 YP_002927522.1 MG1655 equivalent: b2561 YP_002927523.1 MG1655 equivalent: b2562 YP_002927524.1 Catalyzes the formation of holo-ACP, which mediates the essential transfer of acyl fatty acid intermediates during the biosynthesis of fatty acids and lipids YP_002927525.1 involved in the de novo synthesis of pyridoxine (Vitamin B6) YP_002927526.1 involved in DNA repair and RecFOR pathway recombination; RecFOR proteins displace ssDNA-binding protein and facilitate the production of RecA-coated ssDNA YP_002927527.1 Era; Escherichia coli Ras-like protein; Bex; Bacillus Era-complementing segment; essential protein in Escherichia coli that is involved in many cellular processes; GTPase; binds the cell membrane through apparent C-terminal domain; mutants are arrested during the cell cycle; Streptococcus pneumoniae Era binds to RNA and Escherichia coli Era binds 16S rRNA and 30S ribosome YP_002927528.1 cytoplasmic enzyme involved in processing rRNA and some mRNAs; substrates typically have dsRNA regions; forms a homodimer; have N-terminal nuclease and C-terminal RNA-binding domains; requires magnesium as preferred ion for activity YP_002927529.1 catalyzes the cleavage of the amino-terminal leader peptide from secretory proteins YP_002927530.1 binds to the ribosome on the universally-conserved alpha-sarcin loop YP_002927531.1 involved in the reduction of the SoxR iron-sulfur cluster YP_002927532.1 periplasmic protein; interacts with the C-terminal domain of RseA and stimulates RseA binding to sigmaE via the cytoplasmic RseA N-terminal domain which then sequesters sigmaE in the membrane thereby preventing sigmaE associated with core RNAP YP_002927533.1 MG1655 equivalent: b2572 YP_002927534.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor is involved in heat shock and oxidative stress response YP_002927535.1 catalyzes the formation of oxaloacetate from L-aspartate YP_002927536.1 MG1655 equivalent: b2575 YP_002927537.1 facilitates an early step in the assembly of the 50S subunit of the ribosome YP_002927538.1 MG1655 equivalent: b2577 YP_002927539.1 MG1655 equivalent: b2578 YP_002927540.1 stress-induced glycyl radical protein that can replace an oxidatively damaged pyruvate formate-lyase subunit YP_002927541.1 Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine YP_002927542.1 MG1655 equivalent: b2581 YP_002927543.1 MG1655 equivalent: b2582 YP_002927544.1 MG1655 equivalent: b2583 YP_002927545.1 MG1655 equivalent: b2584 YP_002927546.1 catalyzes de novo synthesis of phosphatidylserine from CDP-diacylglycerol and L-serine which leads eventually to the production of phosphatidylethanolamine; bounds to the ribosome YP_002927547.1 MG1655 equivalent: b2586 YP_002927548.1 MG1655 equivalent: b2587 YP_002927549.1 MG1655 equivalent: b2592 YP_002927550.1 MG1655 equivalent: b2593 YP_002927551.1 responsible for synthesis of pseudouridine from uracil at positions 1911, 1915 and 1917 in 23S ribosomal RNA YP_002927552.1 with YaeT, NlpB and YfgL forms a complex involved in the proper assembly and/or targeting of OMPs to the outer membrane; involved in resistance to ampicillin and tetracycline YP_002927553.1 associated with 30S ribosomal subunit; interferes with translation elongation YP_002927555.1 catalyzing the formation of prephenate from chorismate and the formation of phenylpyruvate from prephenate in phenylalanine biosynthesis YP_002927556.1 catalyzes the formation of prephenate from chorismate and the formation of 4-hydroxyphenylpyruvate from prephenate in tyrosine biosynthesis YP_002927557.1 catalyzes the formation of 3-deoxy-D-arabino-hept-2-ulosonate 7 phosphate from phosphoenolpyruvate and D-erythrose 4-phosphate, tyrosine sensitive YP_002927558.1 MG1655 equivalent: b2602 YP_002927559.1 MG1655 equivalent: b2603 YP_002927560.1 MG1655 equivalent: b2604 YP_002927561.1 MG1655 equivalent: b2605 YP_002927562.1 this protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site YP_002927563.1 methylates guanosine-37 in various tRNAs; uses S-adenosyl-L-methionine to transfer methyl group to tRNA YP_002927564.1 Essential for efficient processing of 16S rRNA YP_002927565.1 binds to lower part of 30S body where it stabilizes two domains; required for efficient assembly of 30S; in Escherichia coli this protein has nuclease activity YP_002927566.1 with 4.5S RNA forms a signal recognition particle involved in targeting and integration of inner membrane proteins YP_002927567.1 MG1655 equivalent: b2611 YP_002927568.1 MG1655 equivalent: b4461 YP_002927569.1 with DnaK and DnaJ acts in response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins; may act as a thermosensor YP_002927570.1 catalyzes the phosphorylation of NAD to NADP YP_002927571.1 MG1655 equivalent: b2616 YP_002927572.1 MG1655 equivalent: b2617 YP_002927573.1 MG1655 equivalent: b2618 YP_002927574.1 MG1655 equivalent: b2619 YP_002927575.1 binds to ssrA RNA (tmRNA) and is required for its successful binding to ribosomes; also appears to function in the trans-translation step by promoting accommodation of tmRNA into the ribosomal A site; SmpB protects the tmRNA from RNase R degradation in Caulobacter crescentus; both the tmRNA and SmpB are regulated in cell cycle-dependent manner; functions in release of stalled ribosomes from damaged mRNAs and targeting proteins for degradation YP_002927576.1 CP4-57 prophage; integrase YP_002927577.1 MG1655 equivalent: b2623 YP_002927578.1 MG1655 equivalent: b2624 YP_002927579.1 MG1655 equivalent: b2625 YP_002927580.1 MG1655 equivalent: b2626 YP_002927581.1 MG1655 equivalent: b2627 YP_002927582.1 MG1655 equivalent: b2628 YP_002927583.1 MG1655 equivalent: b2629 YP_002927584.1 MG1655 equivalent: b2630 YP_002927585.1 MG1655 equivalent: b2631 YP_002927586.1 MG1655 equivalent: b2632 YP_002927587.1 MG1655 equivalent: b2633 YP_002927588.1 MG1655 equivalent: b2634 YP_002927589.1 MG1655 equivalent: b2635 YP_002927590.1 MG1655 equivalent: b2636 YP_002927591.1 MG1655 equivalent: b2637 YP_002927592.1 MG1655 equivalent: b2642 YP_002927593.1 MG1655 equivalent: b2643 YP_002927594.1 MG1655 equivalent: b2644 YP_002927595.1 MG1655 equivalent: b4548 YP_002927596.1 MG1655 equivalent: b2645 YP_002927597.1 MG1655 equivalent: b2646 YP_002927598.1 MG1655 equivalent: b2647 YP_002927599.1 in Escherichia coli this gene is induced by carbon starvation and depends on sigma S and cAMP-CRP; the structure of the Gab protein shows it is a member of non-heme iron (II)-dependent oxygenase superfamily which includes clavamini acid synthases; forms homotetramers in solution YP_002927600.1 catalyzed the formation of 2-ketoglutarate from 2-hydroxyglutarate YP_002927601.1 catalyzes the formation of succinate from succinate semialdehyde; NADP dependent YP_002927602.1 catalyzes the formation of succinate semialdehyde and glutamate from 4-aminobutanoate and 2-oxoglutarate YP_002927603.1 MG1655 equivalent: b2663 YP_002927604.1 regulator of gab gene expression YP_002927605.1 MG1655 equivalent: b2665 YP_002927606.1 MG1655 equivalent: b2666 YP_002927607.1 MG1655 equivalent: b2667 YP_002927608.1 MG1655 equivalent: b2668 YP_002927609.1 MG1655 equivalent: b2669 YP_002927610.1 MG1655 equivalent: b2670 YP_002927611.1 MG1655 equivalent: b2671 YP_002927612.1 MG1655 equivalent: b2672 YP_002927613.1 MG1655 equivalent: b2673 YP_002927614.1 in Salmonella NrdI has a stimulatory effect on the ribonucleotide reductase activity of NrdH with NrdEF YP_002927615.1 Catalyzes the rate-limiting step in dNTP synthesis YP_002927616.1 B2 or R2 protein; type 1b enzyme; catalyzes the rate-limiting step in dNTP synthesis; converts nucleotides to deoxynucleotides; forms a homodimer and then a multimeric complex with NrdE YP_002927617.1 with ProWX is involved in the high-affinity uptake of glycine betaine YP_002927618.1 with ProVX is involved in the high-affinity uptake of glycine betaine YP_002927619.1 with ProVW, part of the high-affinity transport system for the osmoprotectant glycine betaine YP_002927620.1 MG1655 equivalent: b2682 YP_002927621.1 MG1655 equivalent: b2683 YP_002927622.1 DNA-binding transcriptional repressor of microcin B17 synthesis and multidrug efflux; negative regulator of the multidrug operon emrAB YP_002927623.1 MG1655 equivalent: b2685 YP_002927624.1 MG1655 equivalent: b2686 YP_002927625.1 catalyzes the hydrolysis of S-ribosylhomocysteine to homocysteine and autoinducer-2 YP_002927626.1 involved in the first step of glutathione biosynthesis YP_002927627.1 MG1655 equivalent: b2689 YP_002927628.1 YqaB; catalyzes the dephosphorylation of fructose 1-phosphate, 6-phosphogluconate and p-nitrophenyl phosphate (pNPP); presents beta-phosphoglucomutase activity at a lower extent YP_002927629.1 affects carbohydrate metabolism; has regulatory role in many processes YP_002927630.1 Catalyzes a two-step reaction, first charging an alanyl molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002927631.1 binds RecA and inhibits RecA-mediated DNA strand exchange and ATP hydrolysis and coprotease activities YP_002927632.1 catalyzes the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs YP_002927633.1 MG1655 equivalent: b2700 YP_002927634.1 membrane-bound lytic murein transglycosylase B; catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine in peptidoglycan YP_002927635.1 MG1655 equivalent: b2702 YP_002927636.1 MG1655 equivalent: b2703 YP_002927637.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002927638.1 catalyzes the conversion of sorbitol 6-phosphate into fructose 6-phosphate YP_002927639.1 regulator for glucitol utilization YP_002927640.1 regulates genes involved in glucitol utilization YP_002927641.1 catalyzes the conversion of D-arabinose 5-phosphate to D-ribulose-5-phosphate YP_002927642.1 Required for the expression of anaerobic nitric oxide (NO) reductase; acts as a transcriptional activator for the norVW operon YP_002927643.1 detoxifies nitric oxide using NADH YP_002927644.1 catalyzes the reduction of the rubredoxin moiety of nitric oxide reductase YP_002927645.1 MG1655 equivalent: b2712 YP_002927646.1 involved in electron transport from formate to hydrogen YP_002927647.1 MG1655 equivalent: b2714 YP_002927648.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002927649.1 MG1655 equivalent: b2716 YP_002927650.1 involved in the C-terminal processing of the large subunit of hydrogenase 3 HycE YP_002927651.1 MG1655 equivalent: b2718 YP_002927652.1 MG1655 equivalent: b2719 YP_002927653.1 electron transfer protein for hydrogenase-3; the formate hydrogenlyase complex comprises of a formate dehydrogenase, unidentified electron carriers and hydrogenase-3; in this non-energy conserving pathway, molecular hydrogen and carbodioxide are released from formate YP_002927654.1 MG1655 equivalent: b2721 YP_002927655.1 MG1655 equivalent: b2722 YP_002927656.1 catalyzes the oxidation of formate to carbon dioxide and molecular hydrogen; formate hydrogenlyase comprises of a formate dehydrogenase, unidentified electron carriers and a hydrogenase (subunit 3) YP_002927657.1 MG1655 equivalent: b2724 YP_002927658.1 regulates several genes involved in the formate hydrogenlyase system; seems to prevent binding of FhlA transcriptional activator to the activator sequence of hyc operon YP_002927659.1 plays a role in hydrogenase nickel cofactor insertion YP_002927660.1 GTP hydrolase involved in nickel liganding into hydrogenases YP_002927661.1 HypC; accessory protein necessary for maturation of the hydrogenase isoforms 1, 2 and 3; forms a complex with HypD, HypE, and HypF proteins, which is the site of ligand biosynthesis and attachment to the iron atom of the NiFe site in the hydrogenase YP_002927662.1 MG1655 equivalent: b2729 YP_002927663.1 MG1655 equivalent: b2730 YP_002927664.1 MG1655 equivalent: b2731 YP_002927665.1 MG1655 equivalent: b2732 YP_002927666.1 This protein performs the mismatch recognition step during the DNA repair process YP_002927667.1 MG1655 equivalent: b2734 YP_002927668.1 MG1655 equivalent: b2735 YP_002927669.1 MG1655 equivalent: b2736 YP_002927670.1 MG1655 equivalent: b2737 YP_002927671.1 MG1655 equivalent: b2738 YP_002927672.1 MG1655 equivalent: b2739 YP_002927673.1 member of the Gnt family of gluconate transporters; not involved in gluconate transport; unknown function YP_002927674.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this sigma factor controls a regulon of genes required for protection against external stresses YP_002927675.1 outer membrane lipoprotein involved in stationary-phase cell survival; similar to LppB virulence determinant from Haemophilus somnus YP_002927676.1 catalyzes the methyl esterification of L-isoaspartyl residues that are formed in damaged proteins YP_002927677.1 catalyzes the conversion of a phosphate monoester to an alcohol and a phosphate YP_002927678.1 catalyzes the modification of U13 in tRNA(Glu) YP_002927679.1 catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate into 2-C-methyl-D-erythritol 2,4-cyclodiphosphate YP_002927680.1 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT; catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate; involved in isoprenoid and isopentenyl-PP biosynthesis; forms homodimers YP_002927681.1 forms a complex with FtsL and FtsQ; colocalizes to the septal region of the dividing cell; membrane protein YP_002927682.1 MG1655 equivalent: b2749 YP_002927683.1 converts ATP and adenylyl sulfate to ADP and 3'-phosphoadenylyl sulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis YP_002927684.1 may be GTPase that regulates ATP sulfurylase activity that is involved in converting ATP and sulfate to diphosphate and adenylylsulfate; in Escherichia coli this enzyme functions in cysteine biosynthesis in the first step; forms a heterodimer with CysD; part of the GTP-binding elongation factor family CysN/NodQ YP_002927685.1 with CysN catalyzes the formation of adenylylsulfate from sulfate and ATP YP_002927686.1 catalyzes the sequential removal of 2 amino-terminal arginines from alkaline phosphatase isozyme 1 to form isozymes 2 and 3 YP_002927687.1 MG1655 equivalent: b2754 YP_002927688.1 MG1655 equivalent: b2755 YP_002927689.1 MG1655 equivalent: b2756 YP_002927690.1 MG1655 equivalent: b2757 YP_002927691.1 MG1655 equivalent: b2758 YP_002927692.1 MG1655 equivalent: b2759 YP_002927693.1 unknown function; in E. coli this protein is regulated by BaeR, a protein involved in resistance to novobiocin and deoxycholate YP_002927694.1 MG1655 equivalent: b2761 YP_002927695.1 catalyzes the reduction of 3'-phosphoadenylyl sulfate into sulfite YP_002927696.1 hemoprotein; NADPH dependent; with the alpha subunit (a flavoprotein) catalyzes the reduction of sulfite to sulfide YP_002927697.1 catalyzes the reduction of sulfite to sulfide in the biosynthesis of L-cysteine from sulfate; a flavoprotein with flavin reductase activity YP_002927698.1 MG1655 equivalent: b2765 YP_002927699.1 MG1655 equivalent: b2766 YP_002927700.1 MG1655 equivalent: b2767 YP_002927701.1 MG1655 equivalent: b2768 YP_002927702.1 MG1655 equivalent: b2769 YP_002927703.1 MG1655 equivalent: b2770 YP_002927704.1 MG1655 equivalent: b2771 YP_002927705.1 MG1655 equivalent: b4463 YP_002927706.1 MG1655 equivalent: b2774 YP_002927707.1 MG1655 equivalent: b2775 YP_002927708.1 MG1655 equivalent: b2776 YP_002927709.1 MG1655 equivalent: b2777 YP_002927710.1 MG1655 equivalent: b2778 YP_002927711.1 enolase; catalyzes the formation of phosphoenolpyruvate from 2-phospho-D-glycerate in glycolysis YP_002927712.1 CTP synthase; cytidine triphosphate synthetase; catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen; in Escherichia coli this enzyme forms a homotetramer YP_002927713.1 functions in degradation of stringent response intracellular messenger ppGpp; in Escherichia coli this gene is co-transcribed with the toxin/antitoxin genes mazEF; activity of MazG is inhibited by MazEF in vitro; ppGpp inhibits mazEF expression; MazG thus works in limiting the toxic activity of the MazF toxin induced during starvation; MazG also interacts with the GTPase protein Era YP_002927714.1 MazF; endoribonuclease; toxin of the ChpA-ChpR toxin-antitoxin system YP_002927715.1 part of the MazF-MazE toxin-antitoxin system; conteracts MazF YP_002927716.1 MG1655 equivalent: b2714 YP_002927717.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats YP_002927718.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats YP_002927719.1 in Escherichia coli this enzyme catalyzes the SAM-dependent methylation of U1939 in the 23S ribomal RNA; binds an iron-sulfur cluster [4Fe-4S] YP_002927720.1 part of the two-component regulatory system with UvrY; involved in the regulation of carbon metabolism via the csrA/csrB regulatory system YP_002927721.1 MG1655 equivalent: b2787 YP_002927722.1 MG1655 equivalent: b2788 YP_002927723.1 MG1655 equivalent: b2789 YP_002927724.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_002927725.1 catalyzes formation of pseudouridine at position 65 in tRNA-Ile1 and tRNA-Asp YP_002927726.1 MG1655 equivalent: b2792 YP_002927727.1 putative SecY regulator that either chelates excess SecY or negatively regulates the SecYE translocase function YP_002927728.1 catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1) in queuosine biosynthesis YP_002927729.1 MG1655 equivalent: b2795 YP_002927730.1 MG1655 equivalent: b2796 YP_002927731.1 MG1655 equivalent: b2797 YP_002927732.1 has 3'-5' exonuclease activity that preferentially acts on ssDNA; also 3'-phosphodiesterase activity at sites with 3' incised apurinic/apyrimidinic sites; can remove 3' phosphoglycolate groups YP_002927733.1 MG1655 equivalent: b2799 YP_002927734.1 catalyzes the formation of glycerone phosphate and (S)-lactaldehyde from L-fuculose 1-phosphate YP_002927735.1 MG1655 equivalent: b2801 YP_002927736.1 catalyzes the conversion of the aldose L-fucose into the corresponding ketose L-fuculose YP_002927737.1 MG1655 equivalent: b2803 YP_002927738.1 MG1655 equivalent: b2804 YP_002927739.1 regulates expression of genes involved in L-fucose utilization YP_002927740.1 MG1655 equivalent: b2806 YP_002927741.1 MG1655 equivalent: b2807 YP_002927742.1 Glycine cleavage system transcriptional activator; activates the gcvTHP operon in the presence of glycine and represses the operon in its absence YP_002927743.1 MG1655 equivalent: b2809 YP_002927744.1 MG1655 equivalent: b2810 YP_002927745.1 MG1655 equivalent: b2811 YP_002927746.1 MG1655 equivalent: b2812 YP_002927747.1 membrane-bound, lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_002927748.1 MG1655 equivalent: b2817 YP_002927749.1 catalyzes the formation of N-acetyl-L-glutamate from L-glutamate and acetyl-CoA in arginine biosynthesis YP_002927750.1 helicase/nuclease; with RecBC catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_002927751.1 helicase/nuclease; with RecCD catalyzes the exonucleolytic cleavage of DNA; RecD has 5' to 3' helicase activity YP_002927752.1 MG1655 equivalent: b2821 YP_002927753.1 catalyzes ATP-dependent exonucleolytic cleavage in either 5'- to 3'- or 3'- to 5'-direction to yield 5'-phosphooligonucleotides; component of the RecBCD (Exo V) helicase/nuclease complex that is essential for recombination YP_002927754.1 MG1655 equivalent: b2823 YP_002927755.1 MG1655 equivalent: b2824 YP_002927756.1 MG1655 equivalent: b2825 YP_002927757.1 MG1655 equivalent: b2826 YP_002927758.1 ThyA; catalyzes formation of dTMP and 7,8-dihydrofolate from 5,10-methylenetetrahydrofolate and dUMP; involved in deoxyribonucleotide biosynthesis; there are 2 copies in some Bacilli, one of which appears to be phage-derived YP_002927759.1 transfers the N-acyl diglyceride moiety to the prospective N-terminal cysteine in prolipoprotein YP_002927760.1 member of a second PTS chain involved in nitrogen metabolism; PtsP phosphorylates NPr YP_002927761.1 hydrolyzes diadenosine polyphosphate YP_002927762.1 MG1655 equivalent: b4610 YP_002927763.1 MutH; Sequence-specific endonuclease that cleaves unmethylated GATC sequences during DNA repair YP_002927764.1 MG1655 equivalent: b2832 YP_002927765.1 MG1655 equivalent: b2833 YP_002927766.1 complements the prephenate dehydrogenase dysfunction of an Escherichia coli tyrosine auxotroph strain; member of the aldo/keto reductase 2 family; crystal structure of purified Escherichia coli protein shows bound NADPH YP_002927767.1 MG1655 equivalent: b2835 YP_002927768.1 Transfers fatty acids to the 1-position via an enzyme-bound acyl-ACP intermediate in the presence of ATP and magnesium. Its physiological function is to regenerate phosphatidylethanolamine from 2-acyl-glycero-3-phosphoethanolamine (2-acyl-GPE) formed by transacylation reactions or degradation by phospholipase A1 YP_002927769.1 controls transcription of galETKM YP_002927770.1 catalyzes the decarboxylation of diaminopimelate into lysine; pyridoxal phosphate(PLP)-binding YP_002927771.1 activates the transcription of the lysA gene encoding diaminopimelate decarboxylase YP_002927772.1 MG1655 equivalent: b2840 YP_002927773.1 MG1655 equivalent: b2841 YP_002927774.1 catalyzes the formation of 3-dehydro-2-deoxy-D-gluconate from 2-deoxy-D-gluconate YP_002927775.1 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase; catalyzes the interconversion of 4-deoxy-L-threo-5-hexosulose uronate to 3-deoxy-D-glycero-2,5-hexodiulosonate YP_002927776.1 Catalyzes the synthesis of acetoacetyl coenzyme A from two molecules of acetyl coenzyme A. It can also act as a thiolase, catalyzing the reverse reaction and generating two-carbon units from the four-carbon product of fatty acid oxidation; in Rhizobia and Ralstonia is involved in PHB biosynthesis YP_002927777.1 MG1655 equivalent: b2845 YP_002927778.1 MG1655 equivalent: b2846 YP_002927779.1 MG1655 equivalent: b2847 YP_002927780.1 MG1655 equivalent: b2848 YP_002927781.1 MG1655 equivalent: b2849 YP_002927782.1 MG1655 equivalent: b2851 YP_002927783.1 MG1655 equivalent: b2852 YP_002927784.1 MG1655 equivalent: b2853 YP_002927785.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats YP_002927786.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats YP_002927787.1 MG1655 equivalent: b2865 YP_002927788.1 putative molybdenum cofactor-binding protein; participates in purine salvage YP_002927789.1 FAD-binding subunit; with XdhA and XdhC participates in purine salvage YP_002927790.1 iron-sulfur-binding subunit; with XdhA and XdhB participates in purine salvage YP_002927791.1 MG1655 equivalent: b2869 YP_002927792.1 MG1655 equivalent: b2870 YP_002927793.1 catalyzes the formation of pyruvate from 2,3-diaminopropionate YP_002927794.1 Zn-dependent extracellular dipeptidase; similar to succinyl-diaminopimelate desuccinylases YP_002927795.1 catalyzes the hydrolytic cleavage of hydantoin with aromatic side chains at the 5'position YP_002927796.1 catalyzes the reversible synthesis of carbamate and ATP from carbamoyl phosphate and ADP YP_002927797.1 MG1655 equivalent: b2875 YP_002927798.1 MG1655 equivalent: b2876 YP_002927799.1 MG1655 equivalent: b2877 YP_002927800.1 with YgfM and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfK mutants are unable to reduce selenate; involved in purine salvage process; seems to act as an oxidoreductase, but sequence similarity suggests it is a dihydrothymine dehydrogenase YP_002927801.1 in Escherichia coli expression is induced in response to phase-specific signals and controlled by RpoS YP_002927802.1 with YgfK and YgfN forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; YgfM contains a FAD domain YP_002927803.1 with YgfK and YgfM forms a selenate reductase, which seems to catalyze the reduction of selenate to selenite; molybdopterin-containing enzyme; oxidase activity toward hypoxanthine and xanthine can be detected if these substrates are present at high concentration YP_002927804.1 MG1655 equivalent: b2882 YP_002927805.1 Catalyzes the deamination of guanine YP_002927806.1 MG1655 equivalent: b4464 YP_002927807.1 MG1655 equivalent: b2886 YP_002927808.1 unknown function; in E. coli the aegA gene is regulated by Fnr, NarXL, and NarQ (but not ArcA), induced under anaerobic conditions and repressed in the presence of nitrate (anaerobic) YP_002927809.1 MG1655 equivalent: b2888 YP_002927810.1 catalyzes the rearrangement of isopentenyl diphosphate to dimethylallyl phosphate YP_002927811.1 class II; LysRS2; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_002927812.1 recognizes the termination signals UGA and UAA during protein translation a specificity which is dependent on amino acid residues residing in loops of the L-shaped tRNA-like molecule of RF2; in some organisms control of PrfB protein levels is maintained through a +1 ribosomal frameshifting mechanism; this protein is similar to release factor 1 YP_002927813.1 5'-3' single-stranded-DNA-specific exonuclease YP_002927814.1 DsbC; periplasmic protein with protein disulfide isomerase activity; this protein also shows disulfide oxidoreductase activity YP_002927815.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; XerD specifically exchanges the bottom strands; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_002927816.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic YP_002927817.1 MG1655 equivalent: b2896 YP_002927818.1 MG1655 equivalent: b2897 YP_002927819.1 physiological role is not clear; not essential for growth but mutants grow poorly; mutations suppress hda null mutations; may be involved in regulation of ATP-DnaA levels; may also be involved in regulation of tRNA modifications; can bind folic acid and tetrahydrofolate; forms a three domain ring-like structure with a central channel; structurally similar to DMGO protein from A. globiformis; shows sequence similarity to yeast CAF17 transcriptional regulator YP_002927820.1 MG1655 equivalent: b2899 YP_002927821.1 MG1655 equivalent: b2900 YP_002927822.1 MG1655 equivalent: b2901 YP_002927823.1 MG1655 equivalent: b2902 YP_002927824.1 acts in conjunction with GvcH to form H-protein-S-aminomethyldihydrolipoyllysine from glycine YP_002927825.1 part of multienzyme complex composed of H, L, P, and T proteins which catalyzes oxidation of glycine to yield carbon dioxide, ammonia, 5,10-CH2-H4folate and a reduced pyridine nucleotide; protein H is involved in transfer of methylamine group from the P to T protein; covalently bound to a lipoyl cofactor YP_002927826.1 catalyzes the transfer of a methylene carbon from the methylamine-loaded GcvH protein to tetrahydrofolate, causing the release of ammonia and the generation of reduced GcvH protein YP_002927827.1 MG1655 equivalent: b2906 YP_002927828.1 Oxygenase that introduces the hydroxyl group at carbon four of 2-octaprenyl-6-methoxyphenol resulting in the formation of 2-octaprenyl-6-methoxy-1,4-benzoquinone YP_002927829.1 exopeptidase able to cleave the peptide bond of the last amino acid if linked to a proline residue; substrate can be as short as a dipeptide YP_002927830.1 the crystal structure of Haemophilus influenzae HI0817 showed that this protein forms dimers; function unknown YP_002927831.1 MG1655 equivalent: b2910 YP_002927832.1 ygfA expression increases five to eight fold in Escherichia coli cells growing as biofilms; unknown function YP_002927833.1 catalyzes the formation of 3-phosphonooxypyruvate from 3-phospho-D-glycerate in serine biosynthesis; can also reduce alpha ketoglutarate to form 2-hydroxyglutarate YP_002927834.1 Catalyzes D-ribose 5-phosphate --> D-ribulose 5-phosphate in the nonoxidative branch of the pentose phosphate pathway YP_002927835.1 specific inhibitor of chromosomal initiation of replication in vitro; binds the three 13-mers in the origin (oriC) to block initiation of replication; also controls genes involved in arginine transport YP_002927836.1 MDM; functions in conversion of succinate to propionate YP_002927837.1 functions in transport of arginine/ornithine; inner membrane ATPase that cleaves ATP and phosphorylates two periplasmic proteins that function as two distinct transport systems, the AO (arginine and ornithine) and LAO (lysine, arginine, and ornithine) periplasmic binding proteins YP_002927838.1 catalyzes the formation of propanoyl-CoA from methylmalonyl-CoA YP_002927839.1 MG1655 equivalent: b2920 YP_002927840.1 MG1655 equivalent: b2921 YP_002927841.1 MG1655 equivalent: b2922 YP_002927842.1 Involved in the export of arginine YP_002927843.1 participates in the regulation of osmotic pressure changes within the cel YP_002927844.1 catalyzes the formation of glycerone phosphate and glyceraldehyde 3-phosphate from fructose 1,6, bisphosphate YP_002927845.1 Converts 3-phospho-D-glycerate to 3-phospho-D-glyceroyl phosphate during the glycolysis pathway YP_002927846.1 NAD-dependent; catalyzes the formation of 4-phosphoerythronate from erythrose 4-phosphate in the biosynthesis of pyridoxine 5'-phosphate YP_002927847.1 MG1655 equivalent: b2928 YP_002927848.1 MG1655 equivalent: b2929 YP_002927849.1 MG1655 equivalent: b2930 YP_002927850.1 MG1655 equivalent: b4465 YP_002927851.1 MG1655 equivalent: b2933 YP_002927852.1 TolM; with CmtA (IIBC), CmtB possibly forms the mannitol-like permease component of the cryptic mannitol phosphotransferase system, which phosphorylates and transports various carbohydrates and polyhydric alcohols in Escherichia coli; cytoplasmic protein YP_002927853.1 catalyzes the formation of ribose 5-phosphate and xylulose 5-phosphate from sedoheptulose 7-phosphate and glyceraldehyde 3-phosphate; can transfer ketol groups between several groups; in Escherichia coli there are two tkt genes, tktA expressed during exponential growth and the tktB during stationary phase YP_002927854.1 MG1655 equivalent: b2936 YP_002927855.1 catalyzes the formation of putrescine from agmatine YP_002927856.1 catalyzes the formation of agmatine from arginine in putrescine and spermidine biosynthesis YP_002927857.1 MG1655 equivalent: b2939 YP_002927858.1 MG1655 equivalent: b2940 YP_002927859.1 MG1655 equivalent: b2941 YP_002927860.1 catalyzes the formation of S-adenosylmethionine from methionine and ATP; methionine adenosyltransferase YP_002927861.1 MG1655 equivalent: b2943 YP_002927862.1 MG1655 equivalent: b2944 YP_002927863.1 MG1655 equivalent: b2945 YP_002927864.1 in Escherichia coli RsmE methylates the N3 position of the U1498 base in 16S rRNA; cells lacking this function can grow, but are outcompeted by wild-type; SAM-dependent m(3)U1498 methyltransferase YP_002927865.1 catalyzes the second step in the glutathione biosynthesis pathway, where it synthesizes ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione YP_002927866.1 MG1655 equivalent: b2948 YP_002927867.1 similar to RuvC resolvase with substantial differences; NMR structural information suggests this protein is monomeric; unknown cellular function YP_002927868.1 MG1655 equivalent: b2950 YP_002927869.1 MG1655 equivalent: b2951 YP_002927870.1 MG1655 equivalent: b2952 YP_002927871.1 MG1655 equivalent: b2953 YP_002927872.1 HAM1-like protein; Rec-dependent growth; RgdB; yggV; it is suspected that this protein functions to remove misincorporated bases such as xanthine or hypoxanthine YP_002927873.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002927874.1 MG1655 equivalent: b2956 YP_002927875.1 catalyzes the formation of aspartate from asparagine, periplasmic; regulated by cyclic AMP receptor protein (CRP) and also induced by anaerobiosis YP_002927876.1 MG1655 equivalent: b2958 YP_002927877.1 MG1655 equivalent: b2959 YP_002927878.1 tRNA (guanine-N(7)-)-methyltransferase; catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA by transferring the methyl residue from S-adenosyl-L-methionine YP_002927879.1 MG1655 equivalent: b2961 YP_002927880.1 MG1655 equivalent: b2962 YP_002927881.1 Murein hydrolase C; membrane-bound; lytic; catalyzes the cleavage of the beta-1,4-glycosidic bond between N-acetylmuramic acid and N-acetylglucosamine residues YP_002927882.1 MG1655 equivalent: b2964 YP_002927883.1 MG1655 equivalent: b2965 YP_002927884.1 MG1655 equivalent: b2966 YP_002927885.1 MG1655 equivalent: b2968 YP_002927886.1 MG1655 equivalent: b2971 YP_002927887.1 MG1655 equivalent: b2972 YP_002927888.1 MG1655 equivalent: b4466 YP_002927889.1 MG1655 equivalent: b2975 YP_002927890.1 catalyzes the formation of malate from glyoxylate and acetyl-CoA YP_002927891.1 MG1655 equivalent: b2977 YP_002927892.1 MG1655 equivalent: b4467 YP_002927893.1 MG1655 equivalent: b4468 YP_002927894.1 MG1655 equivalent: b2979 YP_002927895.1 MG1655 equivalent: b2980 YP_002927896.1 MG1655 equivalent: b2982 YP_002927897.1 MG1655 equivalent: b2983 YP_002927898.1 MG1655 equivalent: b2984 YP_002927899.1 MG1655 equivalent: b2985 YP_002927900.1 MG1655 equivalent: b2986 YP_002927901.1 MG1655 equivalent: b2987 YP_002927902.1 catalyzes the formation of glutathionylspermidine from glutathione and spermidine; also catalyzes the reverse reaction YP_002927903.1 YghU; B2989; one of eight putative glutathione transferase proteins from E. coli YP_002927904.1 MG1655 equivalent: b2990 YP_002927905.1 plays a role in hydrogenase nickel cofactor insertion YP_002927906.1 MG1655 equivalent: b2992 YP_002927907.1 protease responsible for the cleavage of a 15 amino acid peptide from the C-terminal end of the large subunit of hydrogenase 2 (HybC) YP_002927908.1 involved in hydrogen uptake YP_002927909.1 HybB; cytochrome b subunit of the hydrogenase 2 enzyme, composed of HybA, B, C, and O subunits YP_002927910.1 Fe-S ferrodoxin type component; participates in the periplasmic electron-transferring activity of hydrogenase 2 YP_002927911.1 involved in hydrogen uptake YP_002927912.1 MG1655 equivalent: b2998 YP_002927913.1 MG1655 equivalent: b3001 YP_002927914.1 MG1655 equivalent: b3002 YP_002927915.1 MG1655 equivalent: b3003 YP_002927916.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_002927917.1 membrane spanning protein in TonB-ExbB-ExbD complex; involved in the tonB-independent energy-dependent transport iron-siderophore complexes and vitamin B12 into the cell YP_002927918.1 catalyzes the formation of L-homocysteine from cystathionine YP_002927919.1 MG1655 equivalent: b3009 YP_002927920.1 MG1655 equivalent: b3010 YP_002927921.1 MG1655 equivalent: b3011 YP_002927922.1 methylglyoxal reductase/#-keto ester reductase; catalyzes the reduction of 2,5-diketo-D-gluconic acid to 2-keto-L-gulonic acid; also catalyzes the reduction of methylglyoxal, ethyl-2-methylacetoacetate and ethyl-acetoacetate YP_002927923.1 MG1655 equivalent: b3013 YP_002927924.1 MG1655 equivalent: b3014 YP_002927925.1 MG1655 equivalent: b4469 YP_002927926.1 MG1655 equivalent: b3017 YP_002927927.1 MG1655 equivalent: b3018 YP_002927928.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002927929.1 YgiS; uncharacterized periplasmic protein that seems to be part of a binding-protein-dependent transport system YP_002927930.1 MG1655 equivalent: b3021 YP_002927931.1 MG1655 equivalent: b3022 YP_002927932.1 MG1655 equivalent: b3023 YP_002927933.1 MG1655 equivalent: b3024 YP_002927934.1 response regulator in two-component regulatory system with QseC; regulates FlhCD which is the master regulator for flagella and motility genes YP_002927935.1 MG1655 equivalent: b3026 YP_002927936.1 MG1655 equivalent: b3027 YP_002927937.1 MG1655 equivalent: b3028 YP_002927938.1 MG1655 equivalent: b3029 YP_002927939.1 decatenates newly replicated chromosomal DNA and relaxes positive and negative DNA supercoiling YP_002927940.1 Displays esterase activity toward palmitoyl-CoA and pNP-butyrate YP_002927941.1 MG1655 equivalent: b3032 YP_002927942.1 MG1655 equivalent: b3033 YP_002927943.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_002927944.1 trimeric outer membrane protein involved in efflux of hydrophobic/amphipathic molecules; functions with a number of efflux systems in the inner membrane to transport molecules out of the cell YP_002927945.1 MG1655 equivalent: b3037 YP_002927946.1 MG1655 equivalent: b3038 YP_002927947.1 seems to be involved in biofilm formation; in asymptomatic bacteriuria E. coli strains 83972 and VR50, the ygiD gene is upregulated during biofilm formation in urine YP_002927948.1 MG1655 equivalent: b3040 YP_002927949.1 DHBP synthase; functions during riboflavin biosynthesis YP_002927950.1 MG1655 equivalent: b3042 YP_002927951.1 MG1655 equivalent: b3043 YP_002927952.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats YP_002927953.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats YP_002927954.1 MG1655 equivalent: b3047 YP_002927955.1 MG1655 equivalent: b3048 YP_002927956.1 Involved in glycogen synthesis. May be involved in glycogen priming YP_002927957.1 MG1655 equivalent: b3050 YP_002927958.1 MG1655 equivalent: b3051 YP_002927959.1 catalyzes the phosphorylation of D-glycero-D-manno-heptose 7-phosphate to form D,D-heptose-1,7-bisphosphate and catalyzes transfer of ADP to D-glycero-D-manno-heptose 1-phosphate forming ADP-D,D-heptose YP_002927960.1 catalyzes the ATP-dependent addition of AMP to a subunit of glutamine synthetase; also catalyzes the reverse reaction - deadenylation; adenylation/deadenylation of glutamine synthetase subunits is important for the regulation of this enzyme YP_002927961.1 MG1655 equivalent: b3054 YP_002927962.1 MG1655 equivalent: b3055 YP_002927963.1 catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template; phosphohydrolase activities include hydrolysis of pyrophosphate, 5'-nucleoside tri- and diphosphates, NADP, and 2'-AMP with the production of Pi, metal-dependent phosphodiesterase activity for 2',3'-cAMP, 2',3'-cGMP, and 2',3'-cCMP, and hydrolysis 2',3'-cyclic substrates with the formation of 2'-nucleotides and 3'-nucleotides; these phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases YP_002927964.1 BacA; phosphatase activity in Escherichia coli not kinase; involved in bacitracin resistance as bacitracin supposedly sequesters undecaprenyl disphosphate which reduces the pool of lipid carrier available to the cell YP_002927965.1 catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin and can also catalyze the epimerization of carbon 2' of dihydroneopterin and dihydromonapterin YP_002927966.1 involved in acylation of glycerol-3-phosphate to form 1-acyl-glycerol-3 phosphate for use in phospholipid biosynthesis; functions with PlsX YP_002927967.1 activates expression of genes required for L-tartrate-dependent anaerobic growth on glycerol YP_002927968.1 Involved in the tartrate degradation pathway YP_002927969.1 Involved in the tartrate degradation pathway YP_002927970.1 MG1655 equivalent: b3063 YP_002927971.1 in most organisms, only the N-terminal domain is present in a single polypeptide; in some archaea this domain is fused to a kinase domain; this gene is essential for growth in Escherichia coli and Bacillus subtilis; the secreted glycoprotease from Pasteurella haemolytica showed specificity for O-sialoglycosylated proteins; the Pyrococcus structure shows DNA-binding properties, iron-binding, ATP-binding, and AP endonuclease activity YP_002927972.1 a small basic protein that is one of the last in the subunit assembly; omission does not prevent assembly but the subunit is inactive; binds central domain of 16S rRNA YP_002927973.1 synthesizes RNA primers at the replication forks YP_002927974.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; this is the primary sigma factor of bacteria YP_002927975.1 MG1655 equivalent: b3068 YP_002927976.1 MG1655 equivalent: b3070 YP_002927977.1 MG1655 equivalent: b3071 YP_002927978.1 MG1655 equivalent: b3072 YP_002927979.1 catalyzes the formation of 4-aminobutyraldehyde from putrescine and 2-oxoglutarate YP_002927980.1 MG1655 equivalent: b3074 YP_002927981.1 MG1655 equivalent: b3075 YP_002927982.1 in Escherichia coli this is the second beta-galactosidase system YP_002927983.1 in Escherichia coli this is the second beta-galactosidase system YP_002927984.1 MG1655 equivalent: b3078 YP_002927985.1 MG1655 equivalent: b3079 YP_002927986.1 MG1655 equivalent: b3080 YP_002927987.1 MG1655 equivalent: b3081 YP_002927988.1 MG1655 equivalent: b3082 YP_002927989.1 MG1655 equivalent: b3083 YP_002927990.1 MG1655 equivalent: b3084 YP_002927991.1 MG1655 equivalent: b3085 YP_002927992.1 MG1655 equivalent: b3086 YP_002927993.1 MG1655 equivalent: b3087 YP_002927994.1 MG1655 equivalent: b3088 YP_002927995.1 involved in the import of serine and threonine coupled with the import of sodium YP_002927996.1 MG1655 equivalent: b3090 YP_002927997.1 MG1655 equivalent: b3091 YP_002927998.1 catalyzes the interconversion of D-glucuronate to D-fructuronate or D-galacturonate to D-tagaturonate; functions in glucuronic and galacturonic metabolism YP_002927999.1 MG1655 equivalent: b3093 YP_002928000.1 regulates the exuT, uxaCA and uxuRAB operons which encode genes involved in hexuronate utilization. YP_002928001.1 MG1655 equivalent: b3095 YP_002928002.1 MG1655 equivalent: b3096 YP_002928003.1 MG1655 equivalent: b3097 YP_002928004.1 MG1655 equivalent: b3098 YP_002928005.1 MG1655 equivalent: b3099 YP_002928006.1 MG1655 equivalent: b3100 YP_002928007.1 MG1655 equivalent: b3101 YP_002928008.1 MG1655 equivalent: b3102 YP_002928009.1 MG1655 equivalent: b3103 YP_002928010.1 MG1655 equivalent: b3104 YP_002928011.1 MG1655 equivalent: b3105 YP_002928012.1 MG1655 equivalent: b3106 YP_002928013.1 MG1655 equivalent: b3107 YP_002928014.1 MG1655 equivalent: b4470 YP_002928015.1 MG1655 equivalent: b3110 YP_002928016.1 MG1655 equivalent: b4471 YP_002928017.1 MG1655 equivalent: b3113 YP_002928018.1 MG1655 equivalent: b3114 YP_002928019.1 catalyzes the formation of propanoyl phosphate from propanoate and ATP; TdcD also has acetate kinase activities and functions in anaerobic threonine catabolism YP_002928020.1 involved in the import of threonine and serine in combination with the import of a proton YP_002928021.1 catalyzes the formation of 2-oxobutanoate from L-threonine; catabolic YP_002928022.1 regulates the tdcABCDEFG operon which is involved in amino acid degradation YP_002928023.1 participates in controlling the expression of several structural genes for the enzyme threonine dehydratase; TdcR activates the tdcABCDEFG operon YP_002928024.1 MG1655 equivalent: b3120 YP_002928025.1 MG1655 equivalent: b3121 YP_002928026.1 MG1655 equivalent: b3124 YP_002928027.1 catalyzes the reduction of tartronate semialdehyde to glycerate YP_002928028.1 cleaves 5-dehydro-4-deoxy-glucarate and 2-dehydro-3-deoxy-D-glucarate YP_002928029.1 MG1655 equivalent: b3127 YP_002928030.1 MG1655 equivalent: b3128 YP_002928031.1 SohA; PrlF; involved in protein secretion; when overproduced or mutated, it induces growth defect and increased export of a reporter protein; a PrlF mutation induces the activity of the Lon protease, and a Lon-deficient strain suppresses the phenotype conferred by the PrlF mutation YP_002928032.1 MG1655 equivalent: b3130 YP_002928033.1 transcriptional repressor for the agaZVWA and agaSYBCDI operons YP_002928034.1 MG1655 equivalent: b3132 YP_002928035.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake;involved in N-acetylgalactosamine transport YP_002928036.1 MG1655 equivalent: b3136 YP_002928037.1 catalyzes the reversible reaction of dihydroxyacetone phosphate with glyceraldehyde 3-phosphate to produce tagatose 1,6-bisphosphate; in enteric bacteria there are two D-tagatose 1,6-bisphosphate-specific aldolases: KbaY (also called AgaY), involved in catabolism of N-acetyl-galactosamine and D-galactosamine, and GatY which is part of the galactitol catabolism pathway YP_002928038.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport YP_002928039.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane;protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake; involved in N-acetylgalactosamine transport YP_002928040.1 catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; involved in N-acetylgalactosamine transport YP_002928041.1 MG1655 equivalent: b3141 YP_002928042.1 MG1655 equivalent: b3142 YP_002928043.1 MG1655 equivalent: b3143 YP_002928044.1 MG1655 equivalent: b3144 YP_002928045.1 MG1655 equivalent: b3145 YP_002928046.1 MG1655 equivalent: b3146 YP_002928047.1 MG1655 equivalent: b3147 YP_002928048.1 MG1655 equivalent: b3148 YP_002928049.1 Required for the timely initiation of chromosomal replication via direct interactions with the dnaA initiator protein YP_002928050.1 MG1655 equivalent: b3150 YP_002928051.1 MG1655 equivalent: b3151 YP_002928052.1 MG1655 equivalent: b3152 YP_002928053.1 MG1655 equivalent: b3153 YP_002928054.1 MG1655 equivalent: b3154 YP_002928055.1 MG1655 equivalent: b3155 YP_002928056.1 MG1655 equivalent: b3156 YP_002928057.1 MG1655 equivalent: b3157 YP_002928058.1 MG1655 equivalent: b3158 YP_002928059.1 MG1655 equivalent: b3159 YP_002928060.1 MG1655 equivalent: b3160 YP_002928061.1 tryptophan transporter of high affinity YP_002928062.1 participates in the assembly of the large subunit of the ribosome; plays a key role in optimal cell growth at low temperature and is required for normal cell division YP_002928063.1 lipoprotein that appears to be involved in cell division; interacts with the periplasmic protease Prc and may be activated by protease processing YP_002928064.1 MG1655 equivalent: b3164 YP_002928065.1 primary rRNA binding protein; helps nucleate assembly of 30S; binds directly to the 16S rRNA and an intersubunit bridge to the 23S rRNA; autoregulates translation through interactions with the mRNA leader sequence YP_002928066.1 catalyzes isomerization of specific uridines in RNA to pseudouridine; responsible for residues in T loops of many tRNAs YP_002928067.1 associates with free 30S ribosomal subunits; essential for efficient processing of 16S rRNA; in Escherichia coli rbfA is induced by cold shock YP_002928068.1 Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits during initiation of protein synthesis. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex YP_002928069.1 modifies transcription through interactions with RNA polymerase affecting elongation, readthrough, termination, and antitermination YP_002928070.1 in Streptococcus pneumoniae this gene was found to be essential; structure determination of the Streptococcus protein shows that it is similar to a number of other proteins YP_002928071.1 catalyzes the formation of arginosuccinate from citrulline and aspartate in arginine biosynthesis YP_002928072.1 MG1655 equivalent: b3173 YP_002928073.1 MG1655 equivalent: b3175 YP_002928074.1 catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate YP_002928075.1 catalyzes the formation of dihydropteroate from 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate and 4-aminobenzoate YP_002928076.1 inner membrane metalloprotease; may be involved in degradation of aberrant cytoplasmic and membrane proteins YP_002928077.1 Specifically methylates the uridine in position 2552 of 23S rRNA in the fully assembled 50S ribosomal subunit YP_002928078.1 RNA binding protein found associated to pre-50S subunit of the ribosome; putative role in ribosome assembly; necessary for optimal growth but not cell viability YP_002928079.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_002928080.1 penicillin binding protein 4; penicillin sensitive; catalyzes the formation of D-alanine from D-alanyl-D-alanine; one of four, DD-carboxypeptidase low-molecular weight penicillin-binding proteins that remove terminal D-alanine from pentapeptide side chains YP_002928081.1 essential GTPase; exhibits high exchange rate for GTP/GDP; associates with 50S ribosomal subunit; involved in regulation of chromosomal replication YP_002928082.1 MG1655 equivalent: b3184 YP_002928083.1 involved in the peptidyltransferase reaction during translation YP_002928084.1 MG1655 equivalent: b3186 YP_002928085.1 MG1655 equivalent: b3187 YP_002928086.1 activator of maltose metabolism genes YP_002928087.1 adds enolpyruvyl to UDP-N-acetylglucosamine as a component of cell wall formation; gram-positive bacteria have 2 copies of MurA which are active YP_002928088.1 MG1655 equivalent: b3190 YP_002928089.1 MG1655 equivalent: b3191 YP_002928090.1 MG1655 equivalent: b3192 YP_002928091.1 MG1655 equivalent: b3193 YP_002928092.1 MG1655 equivalent: b3194 YP_002928093.1 ATP-binding subunit of a putative ABC toluene efflux transporter YP_002928094.1 YrbG; inner membrane protein involved in cell envelope integrity; putative sodium ion/calcium ion exchanger; in E. coli it is non essential for cell viability; member of the YRBG family of cation/Ca2+ exchangers YP_002928095.1 MG1655 equivalent: b3197 YP_002928096.1 forms homotetramers; catalyzes hydrolysis of KDO 8-P to KDO and inorganic phosphate; functions in lipopolysaccharide biosynthesis YP_002928097.1 MG1655 equivalent: b3199 YP_002928098.1 LptA; periplasmic binding protein part of a putative ABC superfamily of uptake transporters; interacts with LptB protein, the ATP binding component of the uptake system YP_002928099.1 MG1655 equivalent: b3201 YP_002928100.1 sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released; sigma 54 factor is responsible for the expression of enzymes involved in nitrogen assimilation and metabolism; the rhizobia often have 2 copies of this sigma factor; in Rhizobium etli RpoN1 shown to be involved in the assimilation of several nitrogen and carbon sources during free-living aerobic growth and RpoN2 is involved in symbiotic nitrogen fixation; in Bradyrhizobium both RpoN1 and N2 are functional in free-living and symbiotic conditions, rpoN1 gene was regulated in response to oxygen YP_002928101.1 YhbH; resting ribosome-binding protein involved in ribosome stabilization and preservation in stationary phase; binds specifically 100S ribosomes (an inactive ribosome product of a 70S ribosome dimerization); seems to be involved in modulation of the sigma(54) (RpoN) activity for quorum sensing YP_002928102.1 MG1655 equivalent: b3204 YP_002928103.1 MG1655 equivalent: b3205 YP_002928104.1 MG1655 equivalent: b3206 YP_002928105.1 MG1655 equivalent: b3207 YP_002928106.1 glycosyltransferase; polymerizes glycan strands in the peptidoglycan YP_002928107.1 MG1655 equivalent: b3209 YP_002928108.1 sensor-regulator protein which regulates the expression of many genes in response to respiratory growth conditions including anaerobic repression of the arc modulon; hybrid sensory histidine kinase in two-component regulatory system with ArcA YP_002928109.1 MG1655 equivalent: b3211 YP_002928110.1 catalyzes the formation of glutamate from glutamine and alpha-ketoglutarate YP_002928111.1 glutamate synthase is composed of subunits alpha and beta; beta subunit is a flavin adenine dinucleotide-NADPH dependent oxidoreductase; provides electrons to the alpha subunit, which binds L-glutamine and 2-oxoglutarate and forms L-glutamate YP_002928112.1 MG1655 equivalent: b3214 YP_002928113.1 member of the periplasmic pilus chaperone family of proteins YP_002928114.1 MG1655 equivalent: b3216 YP_002928115.1 MG1655 equivalent: b3218 YP_002928116.1 MG1655 equivalent: b3219 YP_002928117.1 MG1655 equivalent: b3220 YP_002928118.1 MG1655 equivalent: b3221 YP_002928119.1 catalyzes the phosphorylation of the N-acetylmannosamine (ManNAc) liberated from N-acetyl-neuraminic acid by the nanA protein YP_002928120.1 Converts N-acetylmannosamine-6-phosphate to N-acetylglucosamine-6-phosphate YP_002928121.1 MG1655 equivalent: b3224 YP_002928122.1 catalyzes the formation of pyruvate and N-acetylmannosamine from N-acetylneuraminic acid YP_002928123.1 Transcriptional repressor of the nan operon that encodes proteins involved in sialic acid utilization YP_002928124.1 YhcL; uncharacterized member of the DcuC family of anaerobic dicarboxylate transporters; probable role in transport of carboxylates across the inner membrane from the periplasm; its encoding gene is not essential for growth and is probably cryptic YP_002928125.1 MG1655 equivalent: b3228 YP_002928126.1 transcriptional activator; required for activation of bacteriophage P1 late promoter; induced by starvation YP_002928127.1 forms a direct contact with the tRNA during translation YP_002928128.1 in Escherichia coli this protein is one of the earliest assembly proteins in the large subunit YP_002928129.1 MG1655 equivalent: b3232 YP_002928130.1 MG1655 equivalent: b3233 YP_002928131.1 MG1655 equivalent: b3234 YP_002928132.1 MG1655 equivalent: b3235 YP_002928133.1 oxidizes malate to oxaloacetate YP_002928134.1 regulates arginine biosynthesis when complexed with arginine by binding at site that overlap the promotors of the arginine biosynthesis genes YP_002928135.1 MG1655 equivalent: b3238 YP_002928136.1 MG1655 equivalent: b3239 YP_002928137.1 with AaeA forms an efflux pump whose substrates are p-hydroxybenzoic acid 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_002928138.1 with AaeB forms an efflux pump whose substrates are p-hydroxybenzoic acid, 6-hydroxy-2-naphthoic and 2-hydroxycinnamate YP_002928139.1 membrane protein AaeX; the gene is a member of the aaeXAB operon YP_002928140.1 MG1655 equivalent: b3243 YP_002928141.1 responsible for the proteolytic maturation of the E. coli pMccB17 plasmid-encoded microcin B17, an exported protein that targets the essential topoisomerase II DNA gyrase; degrades the E. coli plasmid F-encoded CcdA YP_002928142.1 MG1655 equivalent: b4472 YP_002928143.1 involved in the processing of the 5'end of 16S rRNA YP_002928144.1 Maf; overexpression in Bacillus subtilis inhibits septation in the dividing cell YP_002928145.1 part of cell wall structural complex MreBCD; transmembrane component YP_002928146.1 in some organisms this protein is a transmembrane protein while in others it is periplasmic; involved in some organisms with other components of the MreBCD complex and with penicillin binding proteins in the periplasm or cell wall YP_002928147.1 functions in MreBCD complex in some organisms YP_002928148.1 regulates the degradation of the small RNAs CsrB and CsrC; may function to targate RNase E to specific RNA molecules YP_002928149.1 MG1655 equivalent: b3253 YP_002928150.1 composes the biotin carboxyl carrier protein subunit of the acetyl-CoA carboxylase complex, the enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002928151.1 an AccC homodimer forms the biotin carboxylase subunit of the acetyl CoA carboxylase, an enzyme that catalyzes the formation of malonyl-CoA, which in turn controls the rate of fatty acid metabolism YP_002928152.1 MG1655 equivalent: b3257 YP_002928153.1 mediates high affinitiy panthothenate transport which is stimulated by the presence of sodium ions; member of SSS family of sodium/solute symporters; the imported panthothenate is phosphorylated by panthothenate kinase YP_002928154.1 methylates ribosomal protein L11 at multiple amino acid positions; mutations of these genes in Escherichia coli or Thermus thermophilus has no apparent phenotype YP_002928155.1 MG1655 equivalent: b3260 YP_002928156.1 Stimulates excision of phage lambda; affects Mu development; acts as an activator of rRNA and iRNA transcription YP_002928157.1 MG1655 equivalent: b3262 YP_002928158.1 MG1655 equivalent: b3263 YP_002928159.1 MG1655 equivalent: b3264 YP_002928160.1 MG1655 equivalent: b3265 YP_002928161.1 MG1655 equivalent: b3266 YP_002928162.1 MG1655 equivalent: b3267 YP_002928163.1 MG1655 equivalent: b3269 YP_002928164.1 MG1655 equivalent: b3270 YP_002928165.1 MG1655 equivalent: b3271 YP_002928166.1 MG1655 equivalent: b3279 YP_002928167.1 MG1655 equivalent: b3280 YP_002928168.1 AroE; catalyzes the conversion of shikimate to 3-dehydroshikimate YP_002928169.1 RimN; YrdC; required for maturation of 16s RNA; binds preferentially double stranded RNA YP_002928170.1 MG1655 equivalent: b3283 YP_002928171.1 MG1655 equivalent: b3284 YP_002928172.1 MG1655 equivalent: b4473 YP_002928173.1 cleaves off formyl group from N-terminal methionine residues of newly synthesized proteins; binds iron(2+) YP_002928174.1 modifies the free amino group of the aminoacyl moiety of methionyl-tRNA(fMet) which is important in translation initiation; inactivation of this gene in Escherichia coli severely impairs growth YP_002928175.1 catalyzes the methylation of cytosine at position 967 (m5C967) of 16S rRNA; SAM-dependent methyltransferase YP_002928176.1 involved in potassium uptake; found to be peripherally associated with the inner membrane in Escherichia coli; contains an NAD-binding domain YP_002928177.1 forms homopentamer; channel that opens in response to pressure or hypoosmotic shock YP_002928178.1 MG1655 equivalent: b4550 YP_002928179.1 mediates expression of the zinc export protein ZntA in response to high levels of zinc; member of MerR family of transcriptional regulators YP_002928180.1 MG1655 equivalent: b3293 YP_002928181.1 is a component of the macrolide binding site in the peptidyl transferase center YP_002928182.1 catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Dimerization of the alpha subunit is the first step in the sequential assembly of subunits to form the holoenzyme YP_002928183.1 primary rRNA binding protein; nucleates 30S assembly; involved in translational accuracy with proteins S5 and S12; interacts with protein S5; involved in autogeneously regulating ribosomal proteins by binding to pseudoknot structures in the polycistronic mRNA; interacts with transcription complex and functions similar to protein NusA in antitermination YP_002928184.1 located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA; forms part of the Shine-Dalgarno cleft in the 70S ribosome; interacts with S7 and S18 and IF-3 YP_002928185.1 located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA; makes contact with the large subunit via RNA-protein interactions and via protein-protein interactions with L5; contacts P-site tRNA YP_002928186.1 smallest protein in the large subunit; similar to what is found with protein L31 and L33 several bacterial genomes contain paralogs which may be regulated by zinc; the protein from Thermus thermophilus has a zinc-binding motif and contains a bound zinc ion; the proteins in this group have the motif YP_002928187.1 forms heterotrimeric complex in the membrane; in bacteria the complex consists of SecY which forms the channel pore and SecE and SecG; the SecG subunit is not essential; in bacteria translocation is driven via the SecA ATPase YP_002928188.1 late assembly protein YP_002928189.1 L30 binds domain II of the 23S rRNA and the 5S rRNA; similar to eukaryotic protein L7 YP_002928190.1 located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body; contacts S4 and S8; with S4 and S12 plays a role in translational accuracy; mutations in this gene result in spectinomycin resistance YP_002928191.1 binds 5S rRNA along with protein L5 and L25 YP_002928192.1 ribosomal protein L6 appears to have arisen as a result of an ancient gene duplication as based on structural comparison of the Bacillus stearothermophilus protein; RNA-binding appears to be in the C-terminal domain; mutations in the L6 gene confer resistance to aminoglycoside antibiotics such as gentamicin and these occur in truncations of the C-terminal domain; it has been localized to a region between the base of the L7/L12 stalk and the central protuberance YP_002928193.1 binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit YP_002928194.1 located in the peptidyl transferase center and involved in assembly of 30S ribosome subunit; similar to what is observed with proteins L31 and L33, some proteins in this family contain CXXC motifs that are involved in zinc binding; if two copies are present in a genome, then the duplicated copy appears to have lost the zinc-binding motif and is instead regulated by zinc; the proteins in this group do not appear to have the zinc-binding motif YP_002928195.1 part of 50S and 5S/L5/L18/L25 subcomplex; contacts 5S rRNA and P site tRNA; forms a bridge to the 30S subunit in the ribosome by binding to S13 YP_002928196.1 assembly initiator protein; binds to 5' end of 23S rRNA and nucleates assembly of the 50S; surrounds polypeptide exit tunnel YP_002928197.1 binds to the 23S rRNA between the centers for peptidyl transferase and GTPase YP_002928198.1 primary binding protein; helps mediate assembly; involved in translation fidelity YP_002928199.1 one of the stabilizing components for the large ribosomal subunit YP_002928200.1 located in the peptidyl transferase center and may be involved in peptidyl transferase activity; similar to archaeal L10e YP_002928201.1 forms a complex with S10 and S14; binds the lower part of the 30S subunit head and the mRNA in the complete ribosome to position it for translation YP_002928202.1 binds specifically to 23S rRNA during the early stages of 50S assembly; makes contact with all 6 domains of the 23S rRNA in the assembled 50S subunit and ribosome; mutations in this gene result in erythromycin resistance; located near peptidyl-transferase center YP_002928203.1 protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA YP_002928204.1 one of the primary rRNA-binding proteins; required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation YP_002928205.1 binds third domain of 23S rRNA and protein L29; part of exit tunnel YP_002928206.1 L4 is important during the early stages of 50S assembly; it initially binds near the 5' end of the 23S rRNA YP_002928207.1 binds directly near the 3' end of the 23S rRNA, where it nucleates assembly of the 50S subunit; essential for peptidyltransferase activity; mutations in this gene confer resistance to tiamulin YP_002928208.1 NusE; involved in assembly of the 30S subunit; in the ribosome, this protein is involved in the binding of tRNA; in Escherichia coli this protein was also found to be involved in transcription antitermination; NusB/S10 heterodimers bind boxA sequences in the leader RNA of rrn operons which is required for antitermination; binding of NusB/S10 to boxA nucleates assembly of the antitermination complex YP_002928209.1 calcium-binding protein that may be required for the initiation of chromosome replication YP_002928210.1 MG1655 equivalent: b3323 YP_002928211.1 MG1655 equivalent: b3324 YP_002928212.1 MG1655 equivalent: b3325 YP_002928213.1 MG1655 equivalent: b3326 YP_002928214.1 MG1655 equivalent: b3327 YP_002928215.1 MG1655 equivalent: b3328 YP_002928216.1 MG1655 equivalent: b3329 YP_002928217.1 MG1655 equivalent: b3330 YP_002928218.1 MG1655 equivalent: b3331 YP_002928219.1 MG1655 equivalent: b3332 YP_002928220.1 MG1655 equivalent: b3333 YP_002928221.1 MG1655 equivalent: b3334 YP_002928222.1 MG1655 equivalent: b3335 YP_002928223.1 iron storage protein YP_002928224.1 MG1655 equivalent: b3337 YP_002928225.1 MG1655 equivalent: b3338 YP_002928226.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002928227.1 EF-G; promotes GTP-dependent translocation of the ribosome during translation; many organisms have multiple copies of this gene YP_002928228.1 binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit YP_002928229.1 interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone; located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side; mutations in the S12 gene confer streptomycin resistance YP_002928230.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_002928231.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_002928232.1 in Escherichai coli the heterohexameric TusBCD complex is involved in sulfur related that results in thiouridation to U34 position in some tRNAs YP_002928233.1 MG1655 equivalent: b3346 YP_002928234.1 rotamase YP_002928235.1 MG1655 equivalent: b3348 YP_002928236.1 rotamase YP_002928237.1 MG1655 equivalent: b4551 YP_002928238.1 involved in potassium efflux YP_002928239.1 required for KefB activity YP_002928240.1 MG1655 equivalent: b3352 YP_002928241.1 MG1655 equivalent: b3353 YP_002928242.1 MG1655 equivalent: b3354 YP_002928243.1 MG1655 equivalent: b3355 YP_002928244.1 MG1655 equivalent: b3356 YP_002928245.1 complexes with cyclic AMP and binds to specific DNA sites near the promoter to regulate the transcription of several catabolite-sensitive operons YP_002928246.1 MG1655 equivalent: b3358 YP_002928247.1 DapATase; bifunctional enzyme that functions in arginine and lysine biosynthetic pathways; catalyzes the formation of N-acetyl-L-glutamate 5-semialdehyde from 2-oxoglutarate and N(2)-acetyl-L-ornithine or N-succinyl-2-L-amino-6-oxoheptanedioate from 2-oxoglutarate and N-succinyl-L-2,6-diaminoheptanedioate YP_002928248.1 aminodeoxychorismate synthase subunit PabA; with PabB catalyzes the formation of 4-amino-4-deoxychorismate from chorismate and glutamine in para-aminobenzoate synthesis; PabA provides the glutamine amidotransferase activity YP_002928249.1 MG1655 equivalent: b3361 YP_002928250.1 MG1655 equivalent: b3362 YP_002928251.1 MG1655 equivalent: b3363 YP_002928252.1 MG1655 equivalent: b3364 YP_002928253.1 MG1655 equivalent: b3365 YP_002928254.1 involved in reducing nitrite to ammonium to detoxify nitrite accumulation in anaerobic nitrate-respiring cells and regenerate NAD+; bounds to NirB, the cytoplasmic subunit, whose expression is induced at high nitrate concentrations YP_002928255.1 member of the FNT family of formate and nitrite transporters YP_002928256.1 multifunction enzyme consisting of uroporphyrin-III C-methyltransferase, precorrin-2 dehydrogenase and sirohydrochlorin ferrochelatase; catalyzes the methylation of uroporphyrinogen III to form precorrin-2, then catalyzes formation of sirohydrochlorin from precorrin-2 and finally catalyzed the formation of siroheme from sirohydrochlorin YP_002928257.1 MG1655 equivalent: b3369 YP_002928258.1 inner membrane protein possibly involved in fructoselysine transport; member of the flr operon YP_002928259.1 catalyzes the conversion of fructoselysine 6-phosphate to glucose 6-phosphate and lysine YP_002928260.1 YhfOP; YhfP; YhfO; FrlC; catalyzes the interconversion of fructoselysine and psicoselysine YP_002928261.1 MG1655 equivalent: b3374 YP_002928262.1 may act as a transcriptional regulator of a putative fructoselysine-induced operon containing the yhfM, yhfN, yhfO, yhfP, yhfQ, and yhfR genes YP_002928263.1 MG1655 equivalent: b3376 YP_002928264.1 MG1655 equivalent: b3377 YP_002928265.1 MG1655 equivalent: b3378 YP_002928266.1 phosphotriesterase homology protein; PhP; YhfV; member of a family of proteins related to phosphotriesterase (PTE) YP_002928267.1 MG1655 equivalent: b3380 YP_002928268.1 MG1655 equivalent: b3381 YP_002928269.1 MG1655 equivalent: b3382 YP_002928270.1 MG1655 equivalent: b3383 YP_002928271.1 catalyzes a two-step reaction, first charging a tryptophan molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA YP_002928272.1 catalyzes the dephosphorylation of 2-phosphoglycolate to form glycolate and phosphate YP_002928273.1 catalyzes the interconversion of D-ribulose 5-phosphate to xylulose 5-phosphate YP_002928274.1 MG1655 equivalent: b3387 YP_002928275.1 MG1655 equivalent: b3388 YP_002928276.1 catalyzes the formation of 3-dehydroquinate from 3-deoxy-arabino-heptulonate 7-phosphate; functions in aromatic amino acid biosynthesis YP_002928277.1 type I enzyme similar to type II but differentially regulated; major shikimate kinase in fully repressed cells; catalyzes the formation of shikimate 3-phosphate from shikimate in aromatic amino acid biosynthesis YP_002928278.1 outer membrane porin probably involved in uptake of extracellular double-stranded DNA; similar to outer membrane competence protein ComE from Haemophilus influenzae and outer membrane protein PilQ involved in type IV pilus production from Pseudomonas aeruginosa YP_002928279.1 MG1655 equivalent: b3392 YP_002928280.1 MG1655 equivalent: b3393 YP_002928281.1 MG1655 equivalent: b3394 YP_002928282.1 MG1655 equivalent: b3395 YP_002928283.1 bifunctional murein transglycosylase/murein transpeptidase; penicillin-binding protein 1A; involved in the synthesis of cross-linked peptidoglycan from the lipid intermediates in cell wall formation; penicillin-insensitive transglycosylase catalyzes the formation of linear glycan strands and the penicillin-sensitive transpeptidase catalyzes the cross-linking of the peptide subunits YP_002928284.1 ADP-sugar pyrophosphatase; catalyzes the formation of D-ribose 5-phosphate from ADP-ribose; can also act on ADP-mannose and ADP-glucose YP_002928285.1 MG1655 equivalent: b3398 YP_002928286.1 MG1655 equivalent: b3399 YP_002928287.1 MG1655 equivalent: b3400 YP_002928288.1 becomes active under oxidative stress; four conserved cysteines bind a zinc atom when they are in the reduced state and the enzyme is inactive; oxidative stress results in oxidized cysteines, release of zinc, and binding of Hsp33 to aggregation-prone proteins; forms dimers and higher order oligomers YP_002928289.1 MG1655 equivalent: b3402 YP_002928290.1 PEP carboxykinase; PEP carboxylase; PEPCK; catalyzes the phosphorylation and decarboxylation of oxaloacetate to form phosphoenolpyruvate using ATP YP_002928291.1 membrane-localized osmosensor; histidine kinase; in high osmolarity EnvZ autophosphorylates itself and transfers phosphoryl group to OmpR YP_002928292.1 part of two-component system EnvZ/OmpR; regulates transcription of outer membrane porin genes ompC/F; under high osmolarity EnvZ functions as kinase/phosphotransferase and phosphorylates OmpR; the result is increased expression of ompC and repression of ompF; also functions in regulation of other genes; forms dimers upon phosphorylation YP_002928293.1 necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites; arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus YP_002928294.1 MG1655 equivalent: b3407 YP_002928295.1 MG1655 equivalent: b3408 YP_002928296.1 cytoplasmic membrane ferrous uptake system permease; mutations disrupt the ability of Escherichia coli to take up ferrous iron; GTP-binding protein which requires GTP for efficient iron(II) uptake YP_002928297.1 MG1655 equivalent: b3410 YP_002928298.1 MG1655 equivalent: b3411 YP_002928299.1 Shows carboxylesterase activity with a preference for short chain fatty acid esters; involved in pimeloyl-CoA synthesis YP_002928300.1 involved in high-affinity gluconate transport YP_002928301.1 cytoplasmic protein that may be involved in the utilization of double-stranded DNA as a carbon source YP_002928302.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats YP_002928305.1 MG1655 equivalent: b3415 YP_002928306.1 amylomaltase; acts to release glucose from maltodextrins YP_002928307.1 MG1655 equivalent: b3417 YP_002928308.1 Positively regulates the transcription of the maltose regulon whose gene products are responsible for uptake and catabolism of malto-oligosaccharides YP_002928309.1 catalyzes the conversion of terminal3'-phosphate of RNA to the 2',3'-cyclicphosphodiester YP_002928310.1 MG1655 equivalent: b3421 YP_002928311.1 MG1655 equivalent: b3422 YP_002928312.1 represses the glpD, glpFK, glpTQ, and glpACB operons involved in glycerol-3-phosphate metabolism YP_002928313.1 protease responsible for the cleavage between Ser and Asp residues of proteins in regions of high local hydrophilicity YP_002928314.1 belongs to rhodanese family; thiosulfate thiotransferase; in Escherichia coli this enzyme catalyzes the formation of thiocyanate from thiosulfate and cyanide with low efficiency; contains an active site cysteine YP_002928315.1 in Escherichia coli this homodimeric enzyme is expressed under aerobic conditions; anaerobic expression is repressed by the arcAB system; converts sn-glycerol-3-phosphate and ubiquinone-8 to dihydroxy acetone phosphate and ubiquinol-8; associates with the cytoplasmic membrane YP_002928316.1 MG1655 equivalent: b3428 YP_002928317.1 catalyzes the formation of alpha-1,4-glucan chains from ADP-glucose YP_002928318.1 catalyzes the formation of ADP-glucose and diphosphate from ATP and alpha-D-glucose 1-phosphate YP_002928319.1 catalyzes the hydrolysis of the alpha-1,6-glucosidic linkages in partially depolymerized glycogen YP_002928320.1 catalyzes the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxy group in a similar glucan chain YP_002928321.1 catalyzes the formation of 4-aspartyl phosphate from aspartate 4-semialdehyde YP_002928322.1 YhgN; Ec0197; hydrolyzes nucleoside triphosphates with an O6 atom-containing purine base to nucleoside monophosphate and pyrophosphate; seems to play a role in the elimination of aberrant purine-derived nucleotides containing the 6-keto group; shows preference for deoxyinosine triphosphate and xanthosine triphosphate over standard nucleoside triphosphates (dATP, dCTP, dGTP, and dTTP) YP_002928323.1 MG1655 equivalent: b4476 YP_002928324.1 thermoresistant; catalyzes the formation of 6-phospho-D-gluconate from gluconate YP_002928325.1 MG1655 equivalent: b3438 YP_002928326.1 MG1655 equivalent: b3439 YP_002928327.1 MG1655 equivalent: b3440 YP_002928328.1 YhhY; regulated by the fur regulator; unknown function YP_002928329.1 MG1655 equivalent: b3442 YP_002928330.1 MG1655 equivalent: b3444 YP_002928331.1 MG1655 equivalent: b3445 YP_002928332.1 MG1655 equivalent: b4612 YP_002928333.1 MG1655 equivalent: b3446 YP_002928334.1 periplasmic enzyme; post-translationally processed into two subunits which are required for wild-type enzyme activity; cleaves the gammaglutamyl linkages of compounds such as glutathione and transfer the gammaglutamyl group to other amino acids and peptides YP_002928335.1 MG1655 equivalent: b3448 YP_002928336.1 hydrolyzes diesters during transport at the inner face of the cytoplasmic membrane to glycerol-3-phosphate and alcohol; induced when cells are starved for inorganic phosphate YP_002928337.1 part of the UgpABCE glycerol-3-phosphate uptake system YP_002928338.1 with UgpABC is involved in uptake of glycerol-3-phosphate YP_002928339.1 with UgpEC is involved in the uptake of glycerol-3-phosphate YP_002928340.1 with UgpACE is involved in the uptake of glycerol-3-phosphate YP_002928341.1 with LivGHMJ and LivGHMK is part of the high-affinity branched-chain amino acid transport system; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_002928342.1 Part of the ABC transporter complexes LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_002928343.1 Part of the ABC transporter complex LivFGHMJ and LivFGHMK involved in the high-affinity transport of branched-chain amino acids; LivFGHMK is specific for the transport of leucine, while LivFGHMJ is a transporter for leucine, isoleucine, and valine YP_002928344.1 LivHMGF is the membrane component of the LIV-I/LS branched-chain amino acid transporter YP_002928345.1 MG1655 equivalent: b3458 YP_002928346.1 MG1655 equivalent: b3459 YP_002928347.1 MG1655 equivalent: b3460 YP_002928348.1 binds with the catalytic core of RNA polymerase to produce the holoenzyme; this sigma factor is responsible for the expression of heat shock promoters YP_002928349.1 putative ABC transporter, membrane protein YP_002928350.1 putative ATP-binding protein of an ATP-binding cassette transporter; when bound to FtsX, FtsEX localizes to the cell division site and plays a role in the assembly or stability of the septal ring under low-salt growth conditions YP_002928351.1 signal recognition protein receptor; functions in the targeting and insertion of membrane proteins YP_002928352.1 catalyzes the methylation of 16S rRNA at position G966 YP_002928353.1 MG1655 equivalent: b3466 YP_002928354.1 MG1655 equivalent: b3467 YP_002928355.1 MG1655 equivalent: b3468 YP_002928356.1 P-type ATPase involved in the export of lead, cadmium, zinc and mercury YP_002928357.1 TusA; transfers sulfur to TusBCD complex; involved in thiouridation of U34 position of some tRNAs YP_002928358.1 MG1655 equivalent: b3471 YP_002928359.1 MG1655 equivalent: b3472 YP_002928360.1 MG1655 equivalent: b3473 YP_002928361.1 MG1655 equivalent: b3474 YP_002928362.1 MG1655 equivalent: b3475 YP_002928363.1 MG1655 equivalent: b3476 YP_002928364.1 with NikACDE is involved in nickel transport into the cell YP_002928365.1 with NikABDE is involved in nickel transport into the cell YP_002928366.1 with NikABCE is involved in nickel transport into the cell YP_002928367.1 with NikABCD is involved with nickel transport into the cell YP_002928368.1 Inhibits transcription at high concentrations of nickel YP_002928369.1 MG1655 equivalent: b3482 YP_002928370.1 MG1655 equivalent: b3483 YP_002928371.1 MG1655 equivalent: b3484 YP_002928372.1 MG1655 equivalent: b3485 YP_002928373.1 MG1655 equivalent: b3486 YP_002928374.1 MG1655 equivalent: b3487 YP_002928375.1 MG1655 equivalent: b3488 YP_002928376.1 MG1655 equivalent: b3491 YP_002928377.1 MG1655 equivalent: b3492 YP_002928378.1 MG1655 equivalent: b3493 YP_002928379.1 ppGpp-dependent, membrane associated, stress protein produced under conditions of nutrient deprivation, osmotic shock and oxidative stress YP_002928380.1 MG1655 equivalent: b3495 YP_002928381.1 member of the POT family of peptide transporters; probable proton-dependent peptide transporter function YP_002928382.1 predicted SAM-dependent methyltransferase YP_002928383.1 MG1655 equivalent: b3498 YP_002928384.1 MG1655 equivalent: b3499 YP_002928385.1 catalyzes the reduction of 2 glutathione to glutathione disulfide; maintains high levels of reduced glutathione in the cytosol; involved in redox regulation and oxidative defense YP_002928386.1 MG1655 equivalent: b4613 YP_002928387.1 regulates the expression of of the arsRBC involved in resistance to arsenic YP_002928388.1 MG1655 equivalent: b3502 YP_002928389.1 MG1655 equivalent: b3503 YP_002928390.1 MG1655 equivalent: b3505 YP_002928391.1 MG1655 equivalent: b3506 YP_002928392.1 MG1655 equivalent: b3507 YP_002928393.1 inner membrane protein involved in cell density-dependent acid resistance; part of the acid fitness island (AFI) of E. coli YP_002928394.1 MG1655 equivalent: b3509 YP_002928395.1 inactive form YP_002928396.1 MG1655 equivalent: b3511 YP_002928397.1 MG1655 equivalent: b3512 YP_002928398.1 with MdtF and tolC is involved in resistance to rhodamine 6G, erythromycin, doxorubicin and other compounds YP_002928399.1 MG1655 equivalent: b3514 YP_002928400.1 MG1655 equivalent: b3515 YP_002928401.1 regulates genes in response to acid and/or during stationary phase YP_002928402.1 MG1655 equivalent: b3517 YP_002928403.1 MG1655 equivalent: b3518 YP_002928404.1 cytoplasmic; catalyzes the hydrolysis of trehalose to glucose YP_002928405.1 MG1655 equivalent: b3520 YP_002928406.1 MG1655 equivalent: b3521 YP_002928407.1 MG1655 equivalent: b3522 YP_002928408.1 MG1655 equivalent: b3523 YP_002928409.1 MG1655 equivalent: b3524 YP_002928410.1 in Escherichia coli this protein is involved in flagellar function YP_002928411.1 MG1655 equivalent: b3526 YP_002928412.1 MG1655 equivalent: b3527 YP_002928413.1 involved in the transport of C4-dicarboxylates across the membrane YP_002928414.1 HmsP in Yersinia pestis plays a role in invasion of epithelial cells; the EAL-domain portion of HmsP from Y. pestis shows phosphodiesterase activity which is required for the inhibition of biofilm formation; inner membrane protein; similar to a putative phosphodiesterase protein from E. coli YP_002928415.1 cellulose is produced by the multicellular morphotypes of E. coli and Salmonella typhimurium; the cellulose biosynthesis genes bcsA, bcsB, bcsZ and bcsC are constitutively transcribed, however, cellulose synthesis is dependent on the expression of adrA YP_002928416.1 catalyzes the hydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans YP_002928417.1 binds the cellulose synthase activator, bis-(3'-5') cyclic diguanylic acid (c-di-GMP) YP_002928418.1 polymerizes uridine 5'-diphosphate glucose to cellulose; acts with BcsB, BcsZ and BcsC in cellulose biosynthesis YP_002928419.1 MG1655 equivalent: b3535 YP_002928420.1 MG1655 equivalent: b3536 YP_002928421.1 MG1655 equivalent: b3537 YP_002928422.1 MG1655 equivalent: b3538 YP_002928423.1 MG1655 equivalent: b4453 YP_002928424.1 MG1655 equivalent: b3539 YP_002928425.1 Part of the ABC transporter complex DppABCDF involved in the transport of dipeptides YP_002928426.1 DppD and DppF are the ATP-binding components of the ABC dipeptide transport system DppABCDF YP_002928427.1 MG1655 equivalent: b3542 YP_002928428.1 transports peptides consisting of two or three amino acids YP_002928429.1 MG1655 equivalent: b3544 YP_002928430.1 catalyzes the addition of a phosphoethanolamine group to the outer Kdo residue of lipopolysaccharide YP_002928431.1 MG1655 equivalent: b3547 YP_002928432.1 MG1655 equivalent: b3548 YP_002928433.1 constitutive, catalyzes the hydrolysis of alkylated DNA, releasing 3-methyladenine YP_002928434.1 MG1655 equivalent: b3550 YP_002928435.1 MG1655 equivalent: b3551 YP_002928436.1 MG1655 equivalent: b3552 YP_002928437.1 MG1655 equivalent: b3553 YP_002928438.1 MG1655 equivalent: b3554 YP_002928439.1 MG1655 equivalent: b3555 YP_002928440.1 MG1655 equivalent: b3556 YP_002928441.1 MG1655 equivalent: b4455 YP_002928442.1 MG1655 equivalent: b3557 YP_002928443.1 MG1655 equivalent: b3558 YP_002928444.1 glycine--tRNA ligase beta chain; glyS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002928445.1 glycine--tRNA ligase alpha chain; GlyRS; class II aminoacyl tRNA synthetase; tetramer of alpha(2)beta(2); catalyzes a two-step reaction; first charging a glycine molecule by linking its carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002928446.1 MG1655 equivalent: b4553 YP_002928447.1 MG1655 equivalent: b3561 YP_002928448.1 MG1655 equivalent: b3562 YP_002928449.1 MG1655 equivalent: b3563 YP_002928450.1 MG1655 equivalent: b3564 YP_002928451.1 catalyzes the interconversion of D-xylose to D-xylulose YP_002928452.1 periplasmic substrate-binding component of the ATP-dependent xylose transport system; high affinity YP_002928453.1 with XylFH is part of the high affinity xylose ABC transporter YP_002928454.1 MG1655 equivalent: b3568 YP_002928455.1 MG1655 equivalent: b3569 YP_002928456.1 MG1655 equivalent: b3570 YP_002928457.1 periplasmic enzyme that degrades maltodextrins that enter via the outer membrane porin LamB; hydrolyzes alpha-(1,4) glycosidic linkages; contains internal disulfide bonds YP_002928458.1 transaminase C; catalyzes transamination of alanine, valine, and 2-aminobutyrate with their respective 2-keto acids; also catalyzes terminal step in valine biosynthesis YP_002928459.1 MG1655 equivalent: b3573 YP_002928460.1 MG1655 equivalent: b3574 YP_002928461.1 NAD(P)H-dependent; catalyzes the reduction of 2,3-diketo-L-gulonate to 3-keto-L-gulonate YP_002928462.1 MG1655 equivalent: b3576 YP_002928463.1 membrane-spanning protein involved in uptake of 2,3-diketo-L-gulonate; part of the tri-partite ATP-independent periplasmic transport system (TRAP) YiaMNO YP_002928464.1 MG1655 equivalent: b3578 YP_002928465.1 MG1655 equivalent: b3579 YP_002928466.1 MG1655 equivalent: b3580 YP_002928467.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate YP_002928468.1 L-xylulose 5-phosphate 3-epimerase activity not yet demonstrated; may be involved in the utilization of 2,3-diketo-L-gulonate YP_002928469.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_002928470.1 MG1655 equivalent: b3584 YP_002928471.1 MG1655 equivalent: b3585 YP_002928472.1 MG1655 equivalent: b3586 YP_002928473.1 MG1655 equivalent: b3587 YP_002928474.1 MG1655 equivalent: b3588 YP_002928475.1 MG1655 equivalent: b3589 YP_002928476.1 MG1655 equivalent: b3590 YP_002928477.1 catalyzes the formation of selenocysteinyl-tRNA(Sec) from seryl-tRNA(Sec) and L-selenophosphate in selenoprotein biosynthesis YP_002928478.1 MG1655 equivalent: b3592 YP_002928479.1 MG1655 equivalent: b3593 YP_002928480.1 MG1655 equivalent: b3594 YP_002928481.1 MG1655 equivalent: b3596 YP_002928482.1 MG1655 equivalent: b4615 YP_002928483.1 MG1655 equivalent: b3597 YP_002928484.1 MG1655 equivalent: b3598 YP_002928485.1 MG1655 equivalent: b3599 YP_002928486.1 MG1655 equivalent: b3600 YP_002928487.1 Acts as a repressor of the mtlAD operon YP_002928488.1 MG1655 equivalent: b4554 YP_002928489.1 MG1655 equivalent: b3602 YP_002928490.1 MG1655 equivalent: b3603 YP_002928491.1 represses the lctPRD operon YP_002928492.1 flavin mononucleotide-dependent dehydrogenase; functions in aerobic respiration and also has a role in anaerobic nitrate respiration YP_002928493.1 member of the SPOUT superfamily of RNA methyltransferases; no methyltransferase activity observed with certain tRNA substrates YP_002928494.1 catalyzes the O-acetylation of serine YP_002928495.1 catalyzes the NAD(P)H-dependent reduction of glycerol 3-phosphate to glycerone phosphate YP_002928496.1 molecular chaperone that is required for the normal export of envelope proteins out of the cell cytoplasm; in Escherichia coli this proteins forms a homotetramer in the cytoplasm and delivers proteins to be exported to SecA YP_002928497.1 MG1655 equivalent: b3610 YP_002928498.1 MG1655 equivalent: b3611 YP_002928499.1 catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate YP_002928500.1 MG1655 equivalent: b3613 YP_002928501.1 MG1655 equivalent: b3614 YP_002928502.1 MG1655 equivalent: b3615 YP_002928503.1 converts threonine and NAD to 1,2-amino-3-oxobutanoate and NADH; functions in threonine catabolism YP_002928504.1 catalyzes the formation of 2-amino-3-oxobutanoate from acetyl-CoA and glycine YP_002928505.1 MG1655 equivalent: b3618 YP_002928506.1 catalyzes the interconversion between ADP-D-glycero-beta-D-manno-heptose and ADP-L-glycero-beta-D-manno-heptose YP_002928507.1 catalyzes the transfer of the second heptose to the heptosyl-KDO2 moiety of the lipopolysaccharide inner core YP_002928508.1 MG1655 equivalent: b3621 YP_002928509.1 MG1655 equivalent: b3622 YP_002928510.1 MG1655 equivalent: b3623 YP_002928511.1 MG1655 equivalent: b3624 YP_002928512.1 MG1655 equivalent: b3625 YP_002928513.1 MG1655 equivalent: b3626 YP_002928514.1 MG1655 equivalent: b3627 YP_002928515.1 MG1655 equivalent: b3628 YP_002928516.1 MG1655 equivalent: b3629 YP_002928517.1 MG1655 equivalent: b3630 YP_002928518.1 MG1655 equivalent: b3631 YP_002928519.1 MG1655 equivalent: b3632 YP_002928520.1 catalyzes the transfer of 2-keto-3-deoxy-D-manno-octulosonic acid to lipid A YP_002928521.1 Catalyzes the conversion of ATP and pantetheine 4'-phosphate to diphosphate and 3'-dephospho-coA YP_002928522.1 Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases YP_002928523.1 in Escherichia coli BM108, a mutation that results in lack of L33 synthesis had no effect on ribosome synthesis or function; there are paralogous genes in several bacterial genomes, and a CXXC motif for zinc binding and an upstream regulation region of the paralog lacking this motif that are regulated by zinc similar to other ribosomal proteins like L31; the proteins in this group lack the CXXC motif YP_002928524.1 required for 70S ribosome assembly YP_002928525.1 Involved in DNA double-strand break repair and recombination. Promotes the annealing of complementary single-stranded DNA and by simulation of RAD51 recombinase YP_002928526.1 catalyzes the conjugation of cysteine to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, which is then decarboxylated to form 4'-phosphopantotheine YP_002928527.1 catalyzes the formation of dUMP from dUTP YP_002928528.1 FtsZ binding protein; synthetically lethal with a defect in the Min system; this protein is the first identified nucleoid occlusion factor which works along with the Min system to properly position the FtsZ ring assembly YP_002928529.1 involved in fifth step of pyrimidine biosynthesis; converts orotidine 5'-phosphate and diphosphate to orotate and 5-phospho-alpha-D-ribose 1-diphosphate YP_002928530.1 RNase PH; tRNA nucleotidyltransferase; forms hexamers in Bacillus subtilis; phosphoroltic 3'-5' exoribonuclease; involved in maturation of tRNA precursors and removes terminal nucleotides near CCA acceptor arms of mature tRNAs YP_002928531.1 MG1655 equivalent: b3644 YP_002928532.1 MG1655 equivalent: b3645 YP_002928533.1 MG1655 equivalent: b3646 YP_002928534.1 this ligase is similar to LigA but it lacks the C-terminal BRCT domain; catalyzes strand joining of nicked DNA in the presence of a divalent cation and NAD+ YP_002928535.1 Essential for recycling GMP and indirectly, cGMP YP_002928536.1 promotes RNA polymerase assembly or stability; latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits YP_002928537.1 MG1655 equivalent: b3650 YP_002928538.1 specifically modifies tRNA at position G18 YP_002928539.1 catalyzes branch migration in Holliday junction intermediates YP_002928540.1 MG1655 equivalent: b3653 YP_002928541.1 MG1655 equivalent: b3654 YP_002928542.1 MG1655 equivalent: b3655 YP_002928543.1 catalyzes the transfer of alpha-xylosyl residue from alpha-xyloside to xylose, glucose, mannose, fructose, maltose, isomaltose, nigerose, kojibiose, sucrose, and trehalose; shows higher activity against alpha-xylosyl fluoride, isoprimeverose (6-O-alpha-xylopyranosyl-glucopyranose), and alpha-xyloside in xyloglucan oligosaccharides YP_002928544.1 may be involved in the transport of galactosides-pentoses-hexuronides YP_002928545.1 MG1655 equivalent: b3659 YP_002928546.1 MG1655 equivalent: b3660 YP_002928547.1 MG1655 equivalent: b3661 YP_002928548.1 MG1655 equivalent: b4555 YP_002928549.1 experimental results in Escherichia coli suggest that this gene encodes an inosine export protein; member of major facilitator superfamily; MFS YP_002928550.1 MG1655 equivalent: b3663 YP_002928551.1 MG1655 equivalent: b3664 YP_002928552.1 catalyzes the formation of hypoxanthine from adenine; in E. coli this activity has been detected in mutant strains but not in wild type YP_002928553.1 cytoplasmic membrane protein that functions as a monomer; catalyzes the active transport of sugar-phosphates such as glucose-6-phosphate with the obligatory exchange of inorganic phosphate or organophosphate YP_002928554.1 membrane protein regulates uhpT expression YP_002928555.1 Member of the two-component regulatory system UhpB/UhpA involved in the regulation of the uptake of hexose ph YP_002928556.1 response regulator in two-component regulatory system wtih UhpB; phosphorylated UhpA is a positive activator uhpT, a hexose phosphates transporter YP_002928557.1 with IlvB catalyzes the formation of 2-acetolactate from pyruvate, the small subunit is required for full activity and valine sensitivity; E.coli produces 3 isoenzymes of acetolactate synthase which differ in specificity to substrates, valine sensitivity and affinity for cofactors; also known as acetolactate synthase small subunit YP_002928558.1 MG1655 equivalent: b3671 YP_002928559.1 MG1655 equivalent: b3672 YP_002928560.1 MG1655 equivalent: b4617 YP_002928561.1 MG1655 equivalent: b4618 YP_002928562.1 multidrug efflux protein involved in adaptation to low energy shock YP_002928563.1 MG1655 equivalent: b3674 YP_002928564.1 MG1655 equivalent: b3675 YP_002928565.1 MG1655 equivalent: b3676 YP_002928566.1 MG1655 equivalent: b3677 YP_002928567.1 MG1655 equivalent: b3678 YP_002928568.1 uncharacterized member of the SSS superfamily of sodium-dependent solute transporters; unknown function YP_002928569.1 MG1655 equivalent: b3680 YP_002928570.1 MG1655 equivalent: b3684 YP_002928571.1 MG1655 equivalent: b3685 YP_002928572.1 16 kDa heat shock protein B; associates with aggregated proteins, together with ibpA, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress; ATP-independent YP_002928573.1 with IbpB associates with aggregated proteins to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress YP_002928574.1 MG1655 equivalent: b3688 YP_002928575.1 MG1655 equivalent: b3689 YP_002928576.1 FAD/NAD(P)-binding domain YP_002928577.1 MG1655 equivalent: b3691 YP_002928578.1 MG1655 equivalent: b4478 YP_002928579.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and pyruvate from 2-dehydro-3-deoxy-D-galactonate 6-phosphate; functions in galactonate metabolism YP_002928580.1 MG1655 equivalent: b3693 YP_002928581.1 MG1655 equivalent: b4479 YP_002928582.1 MG1655 equivalent: b3696 YP_002928583.1 YidA; catalyzes the dephosphorylation of erythrose 4-phosphate (preferred substrate), mannose 1-phosphate and p-nitrophenyl phosphate; hydrolyzes the alpha-D-glucose-1-phosphate but not the beta form; member of the haloacid dehalogenase-like hydrolases superfamily and Cof family of proteins YP_002928584.1 MG1655 equivalent: b3698 YP_002928585.1 negatively supercoils closed circular double-stranded DNA YP_002928586.1 Required for DNA replication; binds preferentially to single-stranded, linear DNA YP_002928587.1 binds the polymerase to DNA and acts as a sliding clamp YP_002928588.1 binds to the dnaA-box as an ATP-bound complex at the origin of replication during the initiation of chromosomal replication; can also affect transcription of multiple genes including itself. YP_002928589.1 in Escherichia coli transcription of this gene is enhanced by polyamines YP_002928590.1 protein component of RNaseP which catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'terminus; this enzyme also cleaves other RNA substrates YP_002928591.1 MG1655 equivalent: b4557 YP_002928592.1 functions to insert inner membrane proteins into the IM in Escherichia coli; interacts with transmembrane segments; functions in both Sec-dependent and -independent membrane insertion; similar to Oxa1p in mitochondria YP_002928593.1 in Escherichia coli this protein is involved in the biosynthesis of the hypermodified nucleoside 5-methylaminomethyl-2-thiouridine, which is found in the wobble position of some tRNAs and affects ribosomal frameshifting; shows potassium-dependent dimerization and GTP hydrolysis; also involved in regulation of glutamate-dependent acid resistance and activation of gadE YP_002928594.1 MG1655 equivalent: b3707 YP_002928595.1 tryptophan indole-lyase; catalyzes the formation of indole and pyruvate from tryptophan YP_002928596.1 tryptophan transporter of low affinity YP_002928597.1 Confers resistance to chloramphenicol YP_002928598.1 Involved in anaerobic NO protection YP_002928599.1 MG1655 equivalent: b3712 YP_002928600.1 MG1655 equivalent: b3713 YP_002928601.1 MG1655 equivalent: b3714 YP_002928602.1 YieH; catalyzes the dephosphorylation of phosphoenolpyruvate, AMP and p-nitrophenyl phosphate; purine and pyrimidine nucleotides are secondary substrates; member of the haloacid dehalogenase-like hydrolases superfamily YP_002928603.1 might be involved in hypersensitivity to nitrofurzone YP_002928604.1 MG1655 equivalent: b3717 YP_002928605.1 MG1655 equivalent: b3718 YP_002928606.1 MG1655 equivalent: b3719 YP_002928607.1 MG1655 equivalent: b3720 YP_002928608.1 MG1655 equivalent: b3721 YP_002928609.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002928610.1 positive regulator of the beta-glucoside operon; transcriptional antiterminator YP_002928611.1 regulates several genes involved in high affinity phosphate uptake; under conditions of high phosphate concentrations downregulates the PHO regulon YP_002928612.1 ATP-binding protein; PstABCS is an ATP dependent phosphate uptake system which is responsible for inorganic phosphate uptake during phosphate starvation YP_002928613.1 Part of the ABC transporter complex PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_002928614.1 part of the ATP-dependent phosphate uptake system PstABCS responsible for inorganic phosphate (Pi) uptake under Pi starvation conditions YP_002928615.1 MG1655 equivalent: b3728 YP_002928616.1 Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source YP_002928617.1 forms a homotrimer; catalyzes the acetylation of glucosamine-1-phosphate and uridylation of N-acetylglucosamine-1-phosphate to produce UDP-GlcNAc; function in cell wall synthesis YP_002928618.1 part of catalytic core of ATP synthase; alpha(3)beta(3)gamma(1)delta(1)epsilon(1); involved in producing ATP from ADP in the presence of the proton motive force across the membrane YP_002928619.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The beta chain is a regulatory subunit YP_002928620.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is a regulatory subunit YP_002928621.1 produces ATP from ADP in the presence of a proton gradient across the membrane; the alpha chain is a catalytic subunit YP_002928622.1 Produces ATP from ADP in the presence of a proton gradient across the membrane; the delta subunit is part of the catalytic core of the ATP synthase complex YP_002928623.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit B is part of the membrane proton channel. YP_002928624.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit C is part of the membrane proton channel F0 YP_002928625.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit A is part of the membrane proton channel F0 YP_002928626.1 Produces ATP from ADP in the presence of a proton gradient across the membrane. Subunit I associates with the membrane and may be involved with cation translocation YP_002928627.1 glucose-inhibited division protein B; SAM-dependent methyltransferase; methylates the N7 position of guanosine in position 527 of 16S rRNA YP_002928628.1 GidA; glucose-inhibited cell division protein A; involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U) of the wobble uridine base in some tRNAs YP_002928629.1 An electron-transfer protein; flavodoxin binds one FMN molecule, which serves as a redox-active prosthetic group YP_002928630.1 transcriptional repressor of asnA which codes for aspartate-ammonia ligase YP_002928631.1 catalyzes the formation of asparagine from aspartate and ammonia YP_002928632.1 contains a von Willibrand factor type A domain; stimulates the ATPase activity of RavA YP_002928633.1 interacts with LdcI, lysine decarboxylase; may be active in late log/ early stationary phase YP_002928634.1 Responsible for the low-affinity transport of potassium into the cell; involved in potassium ion uptake under hyper-osmotic stress at a low pH YP_002928635.1 cytoplasmic mutarotase that catalyzes the conversion between beta-pyran and beta-furan forms of D-ribose; RbsD is required for efficient ribose utilization in E. coli; rbsD-mutant E. coli strains are unable to use ribose as a sole carbon source YP_002928636.1 with RbsBCD acts to import ribose into the cell; RbsA contains 2 ATP-binding domain YP_002928637.1 functions to transport ribose at high affinity; forms a complex with RbsA2C2B YP_002928638.1 periplasmic substrate-binding component of the ATP-dependent ribose transport system YP_002928639.1 catalyzes the formation of D-ribose 5-phosphate from ribose YP_002928640.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats YP_002928641.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats YP_002928642.1 MG1655 equivalent: b3754 YP_002928643.1 MG1655 equivalent: b3755 YP_002928644.1 Negatively regulates the transcription of the flagellar master operon flhDC by binding to the upstream region of the operon YP_002928645.1 MG1655 equivalent: b3764 YP_002928646.1 among the AAA+ ATPases, the YifB protease family belongs to the Helix 2 insert clade; unknown function YP_002928647.1 MG1655 equivalent: b3766 YP_002928648.1 MG1655 equivalent: b3769 YP_002928649.1 catalyzes the transamination of the branched-chain amino acids to their respective alpha-keto acids YP_002928650.1 catalyzes the dehydration of 2,3-dihydroxy-3-methylbutanoate to 3-methyl-2-oxobutanoate in valine and isoleucine biosynthesis YP_002928651.1 threonine deaminase; threonine dehydratase; in Escherichia coli, IlvA is part of the isoleucine biosynthetic pathway YP_002928652.1 participates in controlling several genes involved in isoleucine and valine biosynthesis; activates the transcription of the ilvC gene in the presence of acetolactate or acetohydroxybutyrate YP_002928653.1 catalyzes the formation of (R)-2,3-dihydroxy-3-methylbutanoate from (S)-2-hydroxy-2-methyl-3-oxobutanoate in valine and isoleucine biosynthesis YP_002928654.1 MG1655 equivalent: b3775 YP_002928655.1 single-stranded DNA-dependent ATPase; initiates unwinding at a nick in the DNA; involved in DNA replication YP_002928656.1 catalyzes the conversion of guanosine 5'-triphosphate,3'-diphosphate (pppGpp) to guanosine 5'-diphosphate,3'-diphosphate (ppGpp); pppGpp and ppGpp control the stringent response during amino acid starvation YP_002928657.1 enables ATP-dependent unwinding of double stranded RNA as a component of the RNA degradosome, a multi-enzyme complex important in RNA processing and messenger RNA degradation YP_002928658.1 MG1655 equivalent: b3781 YP_002928659.1 An RNA-DNA helicase that actively releases nascent mRNAs from paused transcription complexes YP_002928660.1 MG1655 equivalent: b3784 YP_002928661.1 Enterobacterial Common Antigen (ECA) polysaccharide chain length modulation protein YP_002928662.1 MG1655 equivalent: b3786 YP_002928663.1 catalyzes the oxidation of UDP-N-acetyl-D-mannosamine to UDP-N-acetylmannosaminuronic acid YP_002928664.1 MG1655 equivalent: b3788 YP_002928665.1 MG1655 equivalent: b3789 YP_002928666.1 MG1655 equivalent: b3790 YP_002928667.1 catalyzes the formation of dTDP-D-fucosamine from dTDP-4-oxo-6-deoxy-D-glucose in enterobacterial common antigen biosynthesis YP_002928668.1 MG1655 equivalent: b3792 YP_002928669.1 catalyzes the synthesis of a lipid-linked intermediate involved in ECA synthesis YP_002928670.1 enterobacterial common antigen polymerase YP_002928671.1 MG1655 equivalent: b3794 YP_002928672.1 uncharacterized member of the amino acid-polyamine-organocation (APC) superfamily of amino acid transporters; unknown function YP_002928673.1 MG1655 equivalent: b3800 YP_002928674.1 MG1655 equivalent: b3801 YP_002928675.1 MG1655 equivalent: b3802 YP_002928676.1 MG1655 equivalent: b3803 YP_002928677.1 catalyzes the formation of uroporphyrinogen-III from hydroxymethylbilane; functions in tetrapyrrole and heme biosynthesis YP_002928678.1 transformation of porphobilinogen to hydroxymethylbilane in porphyrin biosynthesis YP_002928679.1 catalyzes transfer of adenylyl group of ATP from pyrophosphate to the 3'-hydroxyl group to form cyclic AMP YP_002928680.1 defects in the mitochondrial frataxin protein cause Friedreich ataxis which is an autosomal recessive neurodegenerative disease; based on phylogenomic distribution this protein may have a role in iron-sulfur cluster protein assembly YP_002928681.1 MG1655 equivalent: b4558 YP_002928682.1 involved in lysine biosynthesis; DAP epimerase; produces DL-diaminopimelate from LL-diaminopimelate YP_002928683.1 site-specific tyrosine recombinase which cuts and rejoins DNA molecules; binds cooperatively to specific DNA consensus sites; forms a heterotetrameric complex with XerC; XerCD exhibit similar sequences; essential to convert chromosome dimers to monomers during cell division and functions during plasmid segregation; cell division protein FtsK may regulate the XerCD complex; enzyme from Streptococcus group has unusual active site motifs YP_002928684.1 YigB; member of the haloacid dehalogenase (HAD)-like hydrolases superfamily of protein; unknown function YP_002928685.1 unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present; involved in the post-incision events of nucleotide excision repair and methyl-directed mismatch repair. YP_002928686.1 MG1655 equivalent: b4482 YP_002928687.1 responsible for the influx of magnesium ions YP_002928688.1 MG1655 equivalent: b3817 YP_002928689.1 MG1655 equivalent: b3818 YP_002928690.1 MG1655 equivalent: b3819 YP_002928691.1 MG1655 equivalent: b3820 YP_002928692.1 catalyzes the hydrolysis of phosphatidylcholine YP_002928693.1 functions in blocking illegitimate recombination, enhancing topoisomerase activity, initiating SOS signaling and clearing blocked replication forks; component of the RecF recombinational pathway YP_002928694.1 MG1655 equivalent: b3823 YP_002928695.1 MG1655 equivalent: b3824 YP_002928696.1 lecithinase B; catalyzes the conversion of 1-lysophosphatidylcholine to glycerophosphocholine; can also hydrolyze 2-acyl glycerophosphoethanolamine and other substrates YP_002928697.1 purine and pyrimidine nucleotides are secondary substrates; yigL expression is regulated by heat shock, osmotic shock and starvation of glucose, phosphate or ammonium YP_002928698.1 MG1655 equivalent: b3827 YP_002928699.1 MG1655 equivalent: b3828 YP_002928700.1 catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine to form methionine YP_002928701.1 MG1655 equivalent: b3830 YP_002928702.1 catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate; involved in the pyrimidine salvage pathway YP_002928703.1 YigN; nuclease that may cleave DNA structures arising during the recombination of short-inverted repeats and thereby prevents the inversion of the internal sequence; transcription is induced by DNA-damaging agents such as nalidixic acid or mitomycin C in a LexA-dependent manner YP_002928704.1 Catalyzes the carbon methylation reaction in the biosynthesis of ubiquinone YP_002928705.1 MG1655 equivalent: b3834 YP_002928706.1 an Escherichia coli mutant results in accumulation of octaprenylphenol and no ubiquinone; functions in the formation of 2-octaprenyl-6-hydroxy-phenol from 2-octaprenylphenol in ubiquinone (coenzyme Q) biosynthesis; similar to eukaryotic proteins that exhibit kinase functions YP_002928707.1 TatA; similar to TatE that is found in some proteobacteria; part of system that translocates proteins with a conserved twin arginine motif across the inner membrane; capable of translocating folded substrates typically those with bound cofactors; similar to a protein import system in thylakoid membranes YP_002928708.1 mediates the export of protein precursors bearing twin-arginine signal peptides YP_002928709.1 with TatABE forms the twin-arginine translocation complex which is involved in the transport of proteins across the cytoplasmic membrane YP_002928710.1 magnesium dependent; not involved in the Sec-independent protein export system YP_002928711.1 MG1655 equivalent: b3842 YP_002928712.1 catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol YP_002928713.1 NAD(P)H-flavin reductase; catalyzes the reversible oxidation/reduction of NAD(P) and flavine mononucleotide; in Salmonella and E. coli this protein also reduces aquacob(III)alamin to cob(II)alamin YP_002928714.1 FadA; fatty acid oxidation complex component beta; functions in a heterotetramer with FadB; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_002928715.1 includes enoyl-CoA hydratase, delta(3)-cis-delta(2)-trans-enoyl-CoA isomerase, 3-hydroxyacyl-CoA dehydrogenase, and 3-hydroxybutyryl-CoA epimerase; catalyzes the formation of an hydroxyacyl-CoA by addition of water on enoyl-CoA; also exhibits 3-hydroxyacyl-CoA epimerase and 3-hydroxyacyl-CoA dehydrogenase activities; forms a heterotetramer with FadA; similar to FadI2J2 complex; functions in beta-oxidation of fatty acids YP_002928716.1 catalyzes the hydrolysis of dipeptides with a proline at the C-terminal; also catalyzes the low efficiency hydrolysis of organophosphate di- and tri-esters YP_002928717.1 MG1655 equivalent: b3848 YP_002928718.1 MG1655 equivalent: b3849 YP_002928719.1 catalyzes the oxidation of protoporphyrinogen IX to form protoporphyrin IX YP_002928720.1 in Escherichia coli the MobB protein is not essential but has been found to interact with multiple proteins involved in the molybdopterin guanine dinucleotide cofactor biosynthesis pathway YP_002928721.1 in Escherichia coli MobA links a guanosine 5'-phosphate to molydopterin to form molybdopterin guanine dinucleotide during molybdenum cofactor biosynthesis YP_002928722.1 MG1655 equivalent: b3858 YP_002928723.1 catalyzes the phosphorylation of protein substrates at serine and threonine residues in vitro; specific substrate in vivo has not been identified yet; plays a role in long-term cell survival and expression of surface appendages YP_002928724.1 MG1655 equivalent: b3860 YP_002928725.1 MG1655 equivalent: b3861 YP_002928726.1 MG1655 equivalent: b3862 YP_002928727.1 has 3'-5' exonuclease, 5'-3' exonuclease and 5'-3'polymerase activities, primarily functions to fill gaps during DNA replication and repair YP_002928728.1 binds guanine nucleotides; in Escherichia coli depletion results in defective cell division and filamentation; in Bacillus subtilis this gene is essential YP_002928729.1 MG1655 equivalent: b3866 YP_002928730.1 catalyzes the oxygen-independent formation of protoporphyrinogen-IX from coproporphyrinogen-III YP_002928731.1 response regulator of a two-component regulatory system involved in the activation of nitrogen assimilation genes; interacts with sigma-54 YP_002928732.1 sensory histidine kinase in two-component regulatory system with GlnG; acts as a signal transducer which responds to the nitrogen level of cell and modulates the activity of ntrC by phosphorylation/dephosphorylation YP_002928733.1 forms a homododecamer; forms glutamine from ammonia and glutamate with the conversion of ATP to ADP and phosphate; also functions in the assimilation of ammonia; highly regulated protein controlled by the addition/removal of adenylyl groups by adenylyltransferase from specific tyrosine residues; addition of adenylyl groups results in inactivation of the enzyme YP_002928734.1 MG1655 equivalent: b3871 YP_002928735.1 MG1655 equivalent: b3872 YP_002928736.1 MG1655 equivalent: b3873 YP_002928737.1 MG1655 equivalent: b3874 YP_002928738.1 porin involved in the transport of small molecular weight solutes (up to 600 Daltons) across the cell wall; specific substrate still unknown YP_002928739.1 MG1655 equivalent: b3876 YP_002928740.1 MG1655 equivalent: b3877 YP_002928741.1 MG1655 equivalent: b3878 YP_002928742.1 MG1655 equivalent: b3879 YP_002928743.1 MG1655 equivalent: b3880 YP_002928744.1 MG1655 equivalent: b3881 YP_002928745.1 MG1655 equivalent: b3882 YP_002928746.1 MG1655 equivalent: b3883 YP_002928747.1 MG1655 equivalent: b3884 YP_002928748.1 MG1655 equivalent: b3885 YP_002928749.1 RNase BN; required for 3' maturation of certain phage T4-encoded tRNAs; forms a dimer; specific for immature tRNA substrates containing incorrect residues within the universal CCA sequence; 3' to 5' exoribonuclease YP_002928750.1 hydrolyzes D-tyrosyl-tRNA(Tyr) into D-tyrosine and free tRNA(Tyr); possible defense mechanism against a harmful effect of D-tyrosine YP_002928751.1 MG1655 equivalent: b3888 YP_002928752.1 MG1655 equivalent: b3889 YP_002928753.1 MG1655 equivalent: b3890 YP_002928754.1 required for the formation of active formate dehydrogenase YP_002928755.1 cytochrome b556(FDO) component; heme containing YP_002928756.1 MG1655 equivalent: b3893 YP_002928757.1 MG1655 equivalent: b3894 YP_002928758.1 involved in the production or activity of formate dehydrogenase-H which is active when nitrate is not present during anaerobic growth YP_002928759.1 MG1655 equivalent: b3896 YP_002928760.1 putative repressor of the frv operon, involved in phosphoenolpyruvate:sugar phosphotransferase system YP_002928761.1 with FrvABR is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system which may be involved in the transport and phosphorylation of sugars YP_002928762.1 MG1655 equivalent: b3899 YP_002928763.1 with FrvBRX is part of the phosphoenolpyruvate-dependent sugar phosphotransferase system involved in the transport and phosphorylation of sugars; possibly responsible for the sugar specificity of the system YP_002928764.1 MG1655 equivalent: b3901 YP_002928765.1 MG1655 equivalent: b3902 YP_002928766.1 catalyzes the formation of L-rhamnulose from L-rhamnose YP_002928767.1 catalyzes the ATP-dependent phosphorylation of rhamnulose YP_002928768.1 activates the expression of the rhaBAD operon and rhaT gene YP_002928769.1 activates the expression of rhaRS in response to L-rhamnose YP_002928770.1 transports L-rhamnose and L-lyxose into the cell YP_002928771.1 SodA; manganese binding; only present under aerobic conditions; destroys free radicals YP_002928772.1 transports degraded pectin products into the bacterial cell YP_002928773.1 MG1655 equivalent: b3910 YP_002928774.1 part of two-component CpxA/CpxR system; senses envelope stress; upregulates a number of periplasmic folding and trafficking factors YP_002928775.1 response regulator in two-component regulatory system with CpxA; part of the envelope stress response system YP_002928776.1 repressor of the Cpx envelope stress response pathway which occurs via periplasmic interactions with CpxA; CpxP is degraded by DegP protease especially in the presence of misfolded substrates YP_002928777.1 member of cation diffusion facilitator family; CDF; membrane-bound; induced by both zinc and iron, but does not induce resistance to zinc; can transport zinc(II) in a proton-dependent manner; instead this protein induces iron resistance; forms dimers YP_002928778.1 catalyzes the formation of D-fructose 1,6-bisphosphate from D-fructose 6-phosphate in glycolysis YP_002928779.1 MG1655 equivalent: b3917 YP_002928780.1 MG1655 equivalent: b3918 YP_002928781.1 Reversibly isomerizes the ketone sugar dihydroxyacetone phosphate to the aldehyde sugar glyceraldehyde-3-phosphate YP_002928782.1 MG1655 equivalent: b3920 YP_002928783.1 MG1655 equivalent: b3921 YP_002928784.1 MG1655 equivalent: b3922 YP_002928785.1 with UspC and Usp E is involved in resistance to UV radiation YP_002928786.1 MG1655 equivalent: b3924 YP_002928787.1 type II fructose 1,6-bisphosphatae; in Escherichia coli this protein forms a dimer and binds manganese YP_002928788.1 Converts glycerol and ADP to glycerol-3-phosphate and ADP YP_002928789.1 MG1655 equivalent: b3927 YP_002928790.1 MG1655 equivalent: b3928 YP_002928791.1 regulator of RNase E; increases half-life and abundance of RNAs; interacts with RNase E possibly inhibiting catalytic activity YP_002928792.1 catalyzes the formation of dimethylmenaquinone from 1,4-dihydroxy-2-naphthoate and octaprenyl diphosphate YP_002928793.1 heat shock protein involved in degradation of misfolded proteins YP_002928794.1 heat shock protein involved in degradation of misfolded proteins YP_002928795.1 MG1655 equivalent: b3933 YP_002928796.1 negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins YP_002928797.1 binding of PriA to forked DNA starts the assembly of the primosome, also possesses 3'-5' helicase activity YP_002928798.1 RpmE; there appears to be two types of ribosomal proteins L31 in bacterial genomes; some contain a CxxC motif while others do not; Bacillus subtilis has both types; the proteins in this cluster have the CXXC motif; RpmE is found in exponentially growing Bacilli while YtiA was found after exponential growth; expression of ytiA is controlled by a zinc-specific transcriptional repressor; RpmE contains one zinc ion and a CxxC motif is responsible for this binding; forms an RNP particle along with proteins L5, L18, and L25 and 5S rRNA; found crosslinked to L2 and L25 and EF-G; may be near the peptidyltransferase site of the 50S ribosome YP_002928799.1 member of the NlpC/P60 superfamily of peptidases YP_002928800.1 when combined with S-adenosylmethionine represses the expression of the methionine regulon and of proteins involved in S-adenosylmethionine synthesis YP_002928801.1 catalyzes the formation of cystathionine from L-cysteine and O-succinyl-L-homoserine YP_002928802.1 multifunctional homodimeric enzyme that catalyzes the phosphorylation of aspartate to form aspartyl-4-phosphate as well as conversion of aspartate semialdehyde to homoserine; functions in a number of amino acid biosynthetic pathways YP_002928803.1 MTHFR; catalyzes NADH-linked reduction of 5,10-methylenetetrahydrofolate to 5-methyltetrahydrofolate using FAD as a cofactor YP_002928804.1 MG1655 equivalent: b3942 YP_002928805.1 MG1655 equivalent: b3943 YP_002928806.1 MG1655 equivalent: b3944 YP_002928807.1 forms dimers and octamers; involved in conversion of glycerol to dihydroxy-acetone YP_002928808.1 similar to transaldolase from Escherichia coli; many organisms have multiple copies YP_002928809.1 MG1655 equivalent: b3947 YP_002928810.1 FrwC with FrwB, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; forms translocation channel and contains the specific substrate-binding site YP_002928811.1 FrwB with FrwC, FrwD and PtsA forms a PEP-dependent sugar phosphotransferase system (PTS) permease which may phosphorylate and transport sugars into the cell; cytoplasmic protein that interacts with complex EIIA; contains the second phosphorylation site of the PTS YP_002928812.1 involved in production of D-lactate from glucose under microaerobic conditions; cytoplasmic protein YP_002928813.1 MG1655 equivalent: b3952 YP_002928814.1 FrwD with FrwB, FrwC and PtsA forms a PEP-dependent sugar phosphotransferase system permease which may phosphorylate and transport sugars into the cell; phosphorylated by EIIA; FrwB homolog YP_002928815.1 MG1655 equivalent: b3954 YP_002928816.1 MG1655 equivalent: b3955 YP_002928817.1 catalyzes the formation of oxaloacetate from phosphoenolpyruvate YP_002928818.1 catalyzes the formation of L-ornithine from N(2)-acetyl-L-ornithine in arginine biosynthesis YP_002928819.1 catalyzes the reduction of N-acetyl-5-glutamyl phosphate to N-acetyl-L-glutamate 5-semialdehyde in arginine biosynthesis and the reduction of N-acetyl-gamma-aminoadipyl-phosphate to N-acetyl-L-aminoadipate-semialdehyde in lysine biosynthesis; involved in both the arginine and lysine biosynthetic pathways; lysine is produced via the AAA pathway, lysine from alpha-aminoadipate YP_002928820.1 catalyzes the phosphorylation of N-acetyl-L-glutamate to form N-acetyl-L-glutamate 5-phosphate YP_002928821.1 catalyzes the formation of arginine from (N-L-arginino)succinate YP_002928822.1 Activates the expression of a regulon of hydrogen peroxide-inducible genes such as katG, gor, ahpC, ahpF, oxyS, dps, fur and grxA YP_002928823.1 catalyzes the conversion of NADPH to NADH YP_002928824.1 negatively controls the expression of fabA and fabB, genes involved in the unsaturated fatty acid biosynthesis YP_002928825.1 MG1655 equivalent: b3964 YP_002928826.1 catalyzes the formation of 5-methyl-uridine at position 54 in all tRNAs YP_002928827.1 involved in the active translocation of vitamin B12 (cyanocobalamin) across the outer membrane to the periplasmic space YP_002928828.1 converts L-glutamate to D-glutamate, a component of peptidoglycan YP_002928829.1 catalyzes the reduction of UDP-N-acetylglucosamine enolpyruvate to form UDP-N-acetylmuramate in peptidoglycan biosynthesis YP_002928830.1 catalyzes the formation of biotinyl-5'-AMP, also acts as a transcriptional repressor of the biotin operon YP_002928831.1 catalyzes the formation of (R)-4'-phosphopantothenate in coenzyme A biosynthesis YP_002928832.1 EF-Tu; promotes GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis; when the tRNA anticodon matches the mRNA codon, GTP hydrolysis results; the inactive EF-Tu-GDP leaves the ribosome and release of GDP is promoted by elongation factor Ts; many prokaryotes have two copies of the gene encoding EF-Tu YP_002928833.1 forms a complex with SecY and SecG; SecYEG forms a putative protein-conducting channel to which secA binds and translocates targeted polypeptides across the cytoplasmic membrane, a process driven by ATP and a proton-motive force YP_002928834.1 Modulates Rho-dependent transcription termination YP_002928835.1 binds directly to 23S ribosomal RNA YP_002928836.1 in Escherichia coli and Methanococcus, this protein autoregulates expression; the binding site in the mRNA mimics the binding site in the 23S rRNA YP_002928837.1 binds the two ribosomal protein L7/L12 dimers and anchors them to the large ribosomal subunit YP_002928838.1 present in two forms; L12 is normal, while L7 is aminoacylated at the N-terminal serine; the only multicopy ribosomal protein; 4:1 ratio of L7/L12 per ribosome; two L12 dimers bind L10; critically important for translation efficiency and fidelity; stimulates GTPase activity of translation factors YP_002928839.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates; beta subunit is part of the catalytic core which binds with a sigma factor to produce the holoenzyme YP_002928840.1 DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Subunit beta' binds to sigma factor allowing it to bind to the -10 region of the promoter YP_002928841.1 MG1655 equivalent: b3989 YP_002928842.1 in Escherichia coli this enzyme functions in thiamine biosynthesis along with thiFSGI and iscS; with ThiFSG catalyzes the formation of thiazole phosphate from tyrosine, cysteine and 1-deoxy-D-xylulose-5-phosphate; forms a complex with ThiG; contains an iron-sulfur center YP_002928843.1 functions in thiamine (vitamin B1) biosynthesis; in Bacillus subtilis this enzyme catalyzes the formation of thiazole from dehydroxyglycine and 1-deoxy-D-xylulose-5-phosphate and ThiS-thiocarboxylate YP_002928844.1 with ThiF, ThiG, and ThiO catalyzes the formation of the thiazole moiety of thiamine pyrophosphate YP_002928845.1 MG1655 equivalent: b3992 YP_002928846.1 catalyzes the formation of thiamine monophosphate from 4-methyl-5-(beta-hydroxyethyl)-thiazole monophosphate and 4-amino-5-hydroxymethyl pyrimidine pyrophosphate YP_002928847.1 required for the synthesis of the hydromethylpyrimidine moiety of thiamine YP_002928848.1 binds specifically to the major sigma factor sigma 70; active in stationary phase YP_002928849.1 can catalyze hydrolysis of broad range of dinucleotide pyrophosphates but prefers reduced form of NADH; requires divalent metal ions such as magnesium and manganese and produces two mononucleoside 5'-phosphates YP_002928850.1 catalyzes the formation of coproporphyrinogen from uroporphyrinogen III YP_002928851.1 Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA; cleaves DNA containing urea residues, AP sites, base mismatches, insertion/deletion mismatches, flaps, and pseudo-Y structures YP_002928852.1 MG1655 equivalent: b3999 YP_002928853.1 histone-like DNA-binding protein YP_002928854.1 MG1655 equivalent: b4001 YP_002928855.1 MG1655 equivalent: b4002 YP_002928856.1 MG1655 equivalent: b4003 YP_002928857.1 DNA-binding response regulator in two-component regulatory system with ZraS; response regulator/sigma54 interaction protein YP_002928858.1 catalyzes the formation of N(1)-(5-phospho-D-ribosyl)glycinamide from 5-phospho-D-ribosylamine and glycine in purine biosynthesis YP_002928859.1 involved in de novo purine biosynthesis YP_002928860.1 MG1655 equivalent: b4011 YP_002928861.1 MG1655 equivalent: b4012 YP_002928862.1 catalyzes the formation of O-succinyl-L-homoserine from succinyl-CoA and L-homoserine in methionine biosynthesis YP_002928863.1 Catalyzes the aldol condensation of glyoxylate with acetyl-CoA to form malate as part of the second step of the glyoxylate bypass and an alternative to the tricarboxylic acid cycle YP_002928864.1 MG1655 equivalent: b4015 YP_002928865.1 catalyzes the phosphorylation/dephosphorylation of the enzyme isocitrate dehydrogenase on a specific serine which regulates activity; unphosphorylated IDH is fully active when cells are grown on glucose while the enzyme becomes phosphorylated and inactive in the presence of acetate or ethanol YP_002928866.1 MG1655 equivalent: b4017 YP_002928867.1 regulates the glyoxylate bypass operon (aceBAK), which encodes isocitrate lyase, malate synthase and isocitrate dehydrogenase kinase/phosphorylase YP_002928868.1 one of two methionine synthases in Escherichia coli; MetH catalyzes a methyl transfer reaction from methyltetrahydrofolate to homocysteine to create methionine; requires zinc for activity YP_002928869.1 MG1655 equivalent: b4020 YP_002928870.1 alpha-aspartyl dipeptidase; catalyzes the hydrolysis of dipeptides with an N-terminal aspartate residue; belongs to peptidase S51 family YP_002928871.1 catalyzes the synthesis of pseudouridine from U-2604 in the 23S ribosomal RNA YP_002928872.1 MG1655 equivalent: b4023 YP_002928873.1 catalyzes the formation of 4-phospho-L-aspartate from L-aspartate and ATP; functions in amino acid biosynthesis; lysine sensitive YP_002928874.1 functions in sugar metabolism in glycolysis and the Embden-Meyerhof pathways (EMP) and in gluconeogenesis; catalyzes reversible isomerization of glucose-6-phosphate to fructose-6-phosphate; member of PGI family YP_002928875.1 MG1655 equivalent: b4026 YP_002928876.1 MG1655 equivalent: b4027 YP_002928877.1 MG1655 equivalent: b4028 YP_002928878.1 MG1655 equivalent: b4029 YP_002928879.1 MG1655 equivalent: b4620 YP_002928880.1 MG1655 equivalent: b4030 YP_002928881.1 xylose/proton symporter; member of the major facilitator superfamily (MFS) of transporter YP_002928882.1 with MalKFE is involved in the transport of maltose into the cell YP_002928908.1 Includes: Lysis protein S; Lysis inhibitor YP_002928910.1 MG1655 equivalent: unique YP_002928911.1 MG1655 equivalent: unique YP_002928912.1 MG1655 equivalent: unique YP_002928913.1 MG1655 equivalent: unique YP_002928914.1 MG1655 equivalent: unique YP_002928915.1 MG1655 equivalent: unique YP_002928917.1 Contains: Protein B* YP_002928918.1 Contains: Capsid assembly protein NU3 YP_002928928.1 Contains: Minor tail protein H* YP_002928930.1 COG4672 YP_002928931.1 COG0791 YP_002928936.1 lactose/proton symporter; mediates lactose/proton symport through the membrane by utilizing the proton gradient to drive transport of galactosides; member of major facilitator superfamily; functions as a monomer with 12 transmembrane segments YP_002928937.1 forms a homotetramer; hydrolyzes lactose disaccharide to galactose and glucose; converts lactose to allolactose which is the natural inducer of the lac operon YP_002928938.1 catalyzes the formation of L-tryptophan from L-serine and 1-(indol-3-yl)glycerol 3-phosphate YP_002928939.1 with MalKGE is involved in maltose transport into the cell YP_002928940.1 functions in the MalKFGE ABC transporter complex to transport maltose into the cell by using ATP hydrolysis YP_002928941.1 with malEFG is involved in import of maltose/maltodextrin YP_002928942.1 porin involved in the transport of maltose and maltodextrins YP_002928943.1 MG1655 equivalent: b4037 YP_002928944.1 catalyzes the formation of 4-hydroxybenzoate from chorismate YP_002928945.1 catalyzes the conversion of 4-Hydroxybenzoate into 3-octaprenyl-4-hydroxybenzoate, as part of the ubiquinone biosynthesis pathway YP_002928946.1 PlsB; catalyzes the formation of 1-acyl-sn-glycerol 3-phosphate by transfering the acyl moiety from acyl-CoA YP_002928947.1 MG1655 equivalent: b4042 YP_002928948.1 Represses a number of genes involved in the response to DNA damage YP_002928949.1 MG1655 equivalent: b4044 YP_002928950.1 unknown function; highly abundant protein in vivo; overexpressed under high NaCl concentrations; part of the sigma S regulon; non-essential YP_002928951.1 Acts as a negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes znuACB YP_002928952.1 MG1655 equivalent: b4047 YP_002928953.1 MG1655 equivalent: b4048 YP_002928954.1 MG1655 equivalent: b4049 YP_002928955.1 coordinately regulated along with pspA; PspF-dependent induction in response to secretin overexpression in Yersinia YP_002928956.1 MG1655 equivalent: b4051 YP_002928957.1 unwinds double stranded DNA YP_002928958.1 converts L-alanine to D-alanine which is used in cell wall biosynthesis; binds one pyridoxal phosphate per monomer; forms a homodimer YP_002928959.1 catalyzes the formation of L-glutamate and an aromatic oxo acid from an aromatic amino acid and 2-oxoglutarate YP_002928960.1 MG1655 equivalent: b4621 YP_002928961.1 Class B; non-specific; catalyzes the dephosphorylation of organic phosphomonoesters; also has phosphotransferase activity YP_002928962.1 MG1655 equivalent: b4056 YP_002928963.1 MG1655 equivalent: b4057 YP_002928964.1 The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by uvrB, the uvrA molecules dissociate YP_002928965.1 binds to single stranded DNA and PriA helcase facilitate replication restart YP_002928966.1 MG1655 equivalent: b4060 YP_002928967.1 MG1655 equivalent: b4061 YP_002928968.1 regulates genes involved in response to oxidative stress YP_002928969.1 MG1655 equivalent: b4063 YP_002928970.1 MG1655 equivalent: b4064 YP_002928971.1 MG1655 equivalent: b4065 YP_002928972.1 member of the sodium:solute symporter family; cotranscribed with the acs gene which encodes acetyl coenzyme A synthase; mutations affect acetate uptake YP_002928973.1 MG1655 equivalent: b4068 YP_002928974.1 Acs; catalyzes the conversion of acetate and CoA to acetyl-CoA YP_002928975.1 catalyzes the formate-dependent reduction of nitrite to ammonia; cytochrome C552 YP_002928976.1 part of nitrite reductase complex; NrfB is active at high nitrate conditions; NrfA, B, C, and D are essential for the formate-dependent nitrite reduction to ammonia YP_002928977.1 MG1655 equivalent: b4072 YP_002928978.1 MG1655 equivalent: b4073 YP_002928979.1 with NrfF and NrfG catalyzes the insertion of heme into cytochrome c552 YP_002928980.1 MG1655 equivalent: b4075 YP_002928981.1 MG1655 equivalent: b4076 YP_002928982.1 carrier protein part of the Na(+)-independent, binding-protein-independent glutamate-aspartate transport system YP_002928983.1 MG1655 equivalent: b4078 YP_002928984.1 MG1655 equivalent: b4079 YP_002928985.1 part of a multidrug efflux system involved in resistance to acriflavin, puromycin, erytjhromycin and tetraphenylarsonium chloride; member of the outer membrane factor (OMF) family YP_002928986.1 possibly part of a tripartite efflux system composed of MdtN, MdtO and MdtP which could be involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride YP_002928987.1 with MdtO and MdtP is involved in resistance to puromycin, acriflavine and tetraphenylarsonium chloride YP_002928988.1 MG1655 equivalent: b4622 YP_002928989.1 MG1655 equivalent: b4083 YP_002928990.1 MG1655 equivalent: b4084 YP_002928991.1 MG1655 equivalent: b4085 YP_002928992.1 MG1655 equivalent: b4086 YP_002928993.1 with AlsBC acts to import allose into the cell; AlsA contain 2 ATP-binding domains YP_002928994.1 MG1655 equivalent: b4088 YP_002928995.1 involved in rpiB and als operon repression YP_002928996.1 catalyzes the interconversion of ribose 5-phosphate to ribulose 5-phosphate; enzyme from E. coli shows allose 6-phosphate isomerase activity YP_002928997.1 MG1655 equivalent: b4487 YP_002928998.1 required for the use of phosphonates and phosphite as phosphorus sources YP_002928999.1 PhnO in Salmonella enterica catalyzes the acetylation of a range of aminoalkylphosphonic acids; part of the biochemical pathway that enables the cell to use phosphonates as a phosphorus source; Escherichia coli uses a different mechanism of phosphonate catabolism where PhnO is not essential and seems to play a regulatory role YP_002929000.1 MG1655 equivalent: b4094 YP_002929001.1 MG1655 equivalent: b4095 YP_002929002.1 MG1655 equivalent: b4096 YP_002929003.1 MG1655 equivalent: b4097 YP_002929004.1 MG1655 equivalent: b4098 YP_002929005.1 MG1655 equivalent: b4099 YP_002929006.1 MG1655 equivalent: b4100 YP_002929007.1 MG1655 equivalent: b4101 YP_002929008.1 may be involved in phosphonate uptake and biodegradation YP_002929009.1 MG1655 equivalent: b4105 YP_002929010.1 MG1655 equivalent: b4106 YP_002929011.1 MG1655 equivalent: b4107 YP_002929012.1 MG1655 equivalent: b4108 YP_002929013.1 MG1655 equivalent: b4109 YP_002929014.1 MG1655 equivalent: b4110 YP_002929015.1 MG1655 equivalent: b4111 YP_002929016.1 MG1655 equivalent: b4112 YP_002929017.1 response regulator in two-component regulatory system with BasS YP_002929018.1 with ZipA and an unidentified 24 kDa protein forms a complex involved in cell division YP_002929019.1 MG1655 equivalent: b4115 YP_002929020.1 MG1655 equivalent: b4116 YP_002929021.1 MG1655 equivalent: b4117 YP_002929022.1 MG1655 equivalent: b4118 YP_002929023.1 MG1655 equivalent: b4119 YP_002929024.1 MG1655 equivalent: b4120 YP_002929025.1 MG1655 equivalent: b4121 YP_002929026.1 MG1655 equivalent: b4122 YP_002929027.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to DcuA; DcuA and DcuB function as independent and mutually redundant C4-dicarboxylate (aspartate, malate, fumarate and succinate) transporters YP_002929028.1 response regulator in two-component regulatory system with DcuS; phosphorylated DcuR activates transcription of genes involved in anaerobic fumarate respiration YP_002929029.1 C4-dicarboxylate-sensing histidine kinase; part of two-component regulatory system with DcuR; regulates anaerobic fumarate respiration YP_002929030.1 MG1655 equivalent: b4126 YP_002929031.1 MG1655 equivalent: b4127 YP_002929032.1 MG1655 equivalent: b4128 YP_002929033.1 MG1655 equivalent: b4559 YP_002929034.1 class II; inducible; catalyzes a two-step reaction, first charging a lysine molecule by linking its carboxyl group to the alpha-phosphate of ATP, followed by transfer of the aminoacyl-adenylate to its tRNA; induced by high temperature, anaerobiosis, and low pH; in Methanosarcina barkeri, LysRS2 charges both tRNA molecules for lysine that exist in this organism and in addition can charge the tRNAPyl with lysine in the presence of LysRS1 YP_002929035.1 MG1655 equivalent: b4130 YP_002929036.1 MG1655 equivalent: b4131 YP_002929037.1 antiporter protein responsible for lysine import and cadaverine export; member of the lysine-dependent acid resistance system 4 (AR4); inner membrane protein YP_002929038.1 regulates the cadBA operon YP_002929039.1 MG1655 equivalent: b4135 YP_002929040.1 two electrons are transferred from cytoplasmic NADPH to thioredoxin and then to the inner membrane protein DsbD which keeps the disulfide isomerase DsbC in a reduced state in the oxidizing periplasm; DsbC in turns rearranges incorrectly made disulfide bonds in the periplasm YP_002929041.1 copper binding protein required for copper tolerance; involved in resistance toward heavy metals YP_002929042.1 functions in anaerobic transport of C4-dicarboxylate compounds such as fumarate; similar to dcuB YP_002929043.1 catalyzes the formation of fumarate from aspartate YP_002929044.1 F exclusion of bacteriophage T7; overproduction of this protein in Escherichia coli inhibits the F plasmid-mediated exclusion of bacteriophage T7; interacts with the F plasmid-encoded PifA protein; inner membrane protein YP_002929045.1 uncharacterized member of the APC superfamily of amino acid transporters; unknown function YP_002929046.1 10 kDa chaperonin; Cpn10; GroES; forms homoheptameric ring; binds to one or both ends of the GroEL double barrel in the presence of adenine nucleotides capping it; folding of unfolded substrates initiates in a GroEL-substrate bound and capped by GroES; release of the folded substrate is dependent on ATP binding and hydrolysis in the trans ring YP_002929047.1 60 kDa chaperone family; promotes refolding of misfolded polypeptides especially under stressful conditions; forms two stacked rings of heptamers to form a barrel-shaped 14mer; ends can be capped by GroES; misfolded proteins enter the barrel where they are refolded when GroES binds; many bacteria have multiple copies of the groEL gene which are active under different environmental conditions; the B.japonicum protein in this cluster is expressed constitutively; in Rhodobacter, Corynebacterium and Rhizobium this protein is essential for growth YP_002929048.1 MG1655 equivalent: b4144 YP_002929049.1 MG1655 equivalent: b4145 YP_002929050.1 MG1655 equivalent: b4146 YP_002929051.1 Involved in peptide bond synthesis; alters the affinity of the ribosome for aminoacyl-tRNA YP_002929052.1 acts as and antidote to the bacteriolytic entericidin B in the EcnAB toxin-antitoxin complex YP_002929053.1 MG1655 equivalent: b4411 YP_002929054.1 member of the SMR family of proton-dependent drug efflux transporters; quaternary ammonium compound efflux pump; confers resistance to cetylpyridinium, cetyldimethylethyl ammonium and cetrimide cations YP_002929055.1 lipocalin; globomycin-sensitive outer membrane lipoprotein YP_002929056.1 MG1655 equivalent: b4150 YP_002929057.1 in conjunction with FrdC acts to anchor the catalytic components of the fumarate reductase to the cytoplasmic membrane YP_002929058.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_002929059.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_002929060.1 part of four member fumarate reductase enzyme complex FrdABCD which catalyzes the reduction of fumarate to succinate during anaerobic respiration; FrdAB are the catalytic subcomplex consisting of a flavoprotein subunit and an iron-sulfur subunit, respectively; FrdCD are the membrane components which interact with quinone and are involved in electron transfer; the catalytic subunits are similar to succinate dehydrogenase SdhAB YP_002929061.1 lysine--tRNA ligase beta chain; poxA; class II aminoacyl tRNA synthetase; catalyzes a two-step reaction; first charging a lysine molecule by linking the carboxyl group to the alpha-phosphate of ATP; second by transfer of the aminoacyl-adenylate to its tRNA YP_002929062.1 MG1655 equivalent: b4156 YP_002929063.1 MG1655 equivalent: b4157 YP_002929064.1 MG1655 equivalent: b4158 YP_002929065.1 MG1655 equivalent: b4159 YP_002929066.1 catalyzes the decarboxylation of phosphatidyl-L-serine to phosphatidylethanoleamine YP_002929067.1 EngC; RsgA; CpgA; circularly permuted GTPase; ribosome small subunit-dependent GTPase A; has the pattern G4-G1-G3 as opposed to other GTPases; interacts strongly with 30S ribosome which stimulates GTPase activity YP_002929068.1 3'-5' exoribonuclease specific for small oligoribonuclotides YP_002929069.1 MG1655 equivalent: b4166 YP_002929070.1 MG1655 equivalent: b4167 YP_002929071.1 possibly involved in cell wall synthesis YP_002929072.1 MG1655 equivalent: b4169 YP_002929073.1 This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. Promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex YP_002929074.1 IPP transferase; isopentenyltransferase; involved in tRNA modification; in Escherichia coli this enzyme catalyzes the addition of a delta2-isopentenyl group from dimethylallyl diphosphate to the N6-nitrogen of adenosine adjacent to the anticodon of tRNA species that read codons starting with uracil; further tRNA modifications may occur; mutations in miaA result in defects in translation efficiency and fidelity YP_002929075.1 Stimulates the elongation of poly(A) tails YP_002929076.1 involved in modulation of proteins HflK and HflC; part of the hflA locus (high frequency of lysogenization) which governs the lysis-lysogeny decision of bacteriophage lambda by controlling stability of the phage cII protein YP_002929077.1 with HflC inhibits proteolysis of lambda cII protein by FtsH YP_002929078.1 with HflK inhibits proteolysis of lambda cII protein by FtsH YP_002929079.1 MG1655 equivalent: b4176 YP_002929080.1 catalyzes the formation of N6-(1,2,-dicarboxyethyl)-AMP from L-aspartate, inosine monophosphate and GTP in AMP biosynthesis YP_002929081.1 negatively regulates the transcription of genes upregulated by nitrosative stress YP_002929082.1 3'-5'exoribonuclease that acts nonspecifically on poly(A), poly(U) and ribosomal RNAs YP_002929083.1 Specifically methylates the ribose of guanosine 2251 in 23S rRNA YP_002929084.1 MG1655 equivalent: b4181 YP_002929085.1 MG1655 equivalent: b4182 YP_002929086.1 MG1655 equivalent: b4183 YP_002929087.1 MG1655 equivalent: b4184 YP_002929088.1 MG1655 equivalent: b4185 YP_002929089.1 MG1655 equivalent: b4186 YP_002929090.1 catalyzes the formation of 3-methylcrotonyl-CoA from isovaleryl-CoA YP_002929091.1 MG1655 equivalent: b4188 YP_002929092.1 in Escherichia coli, mutation of this gene affects biofilm maturation, stress response, and motility YP_002929093.1 YjfP; esterase activity towards palmitoyl-CoA and pNP-butyrate in vitro; unknown function and substrate in vivo YP_002929094.1 negative regulator of ulaG and ulaABCDEF YP_002929095.1 MG1655 equivalent: b4192 YP_002929096.1 membrane component; functions with enzymes IIB (sgaB; ulaB) and IIA (sgaA; ulaC) enzyme I and HPr for anaerobic utilization and uptake of L-ascorbate; sgaTBA are regulated by yifQ as well as Crp and Fnr YP_002929097.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_002929098.1 involved in the phosphorylation and transport of sugars across the cell membrane; protein IIA transfers a phosphoryl group to IIB which then transfers the phosphoryl group to the sugar; IIC forms the translocation channel for the sugar uptake YP_002929099.1 catalyzes the formation of L-xylulose-5-phosphate from 3-keto-L-gulonate-6-phosphate in anaerobic L-ascorbate utilization YP_002929100.1 UlaE; catalyzes the epimerization of L-ribulose-5-phosphate into L-xylulose-5-phosphate; part of the anaerobic L-ascorbate degradation pathway YP_002929101.1 catalyzes the isomerization of L-ribulose 5-phosphate to D-xylulose 5-phosphate in the anaerobic catabolism of L-ascorbate; links the arabinose metabolic pathway to the pentose phosphate pathway and allows the bacteria to use arabinose as an energy source YP_002929102.1 MG1655 equivalent: b4199 YP_002929103.1 binds cooperatively with S18 to the S15-16S complex, allowing platform assembly to continue with S11 and S21 YP_002929104.1 binds single-stranded DNA at the primosome assembly site YP_002929105.1 binds as a heterodimer with protein S6 to the central domain of the 16S rRNA; helps stabilize the platform of the 30S subunit YP_002929106.1 in Escherichia coli this protein is wrapped around the base of the L1 stalk YP_002929107.1 MG1655 equivalent: b4204 YP_002929108.1 MG1655 equivalent: b4206 YP_002929109.1 FKBP-type; rotamase; catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides YP_002929110.1 involved in the transport across the cytoplasmic membrane of D-alanine, D-serine and glycine YP_002929111.1 Involved in anaerobic NO protection and iron metabolism YP_002929112.1 MG1655 equivalent: b4210 YP_002929113.1 MG1655 equivalent: b4211 YP_002929114.1 MG1655 equivalent: b4212 YP_002929115.1 periplasmic enzyme; functions during ribonucleic acid degradation; 2',3'-cyclic nucleotides are first converted to 3'-nucleotide and then cleaved to yield a ribonucleotide and a phosphate YP_002929116.1 catalyzes the formation of AMP from adenosine-3',5'-bisphosphate YP_002929117.1 MG1655 equivalent: b4215 YP_002929118.1 MG1655 equivalent: b4216 YP_002929119.1 MG1655 equivalent: b4217 YP_002929120.1 MG1655 equivalent: b4218 YP_002929121.1 this stereospecific enzymes reduces the S isomer of methionine sulfoxide while MsrB reduces the R form; provides protection against oxidative stress YP_002929122.1 MG1655 equivalent: b4220 YP_002929123.1 MG1655 equivalent: b4221 YP_002929124.1 MG1655 equivalent: b4222 YP_002929125.1 part of the toxin-antitoxin ChpB-ChpS system YP_002929126.1 toxin of the ChpB-ChpS toxin-antitoxin system YP_002929127.1 catalyzes the hydrolysis of pyrophosphate to phosphate YP_002929128.1 MG1655 equivalent: b4227 YP_002929129.1 MG1655 equivalent: b4485 YP_002929130.1 MG1655 equivalent: b4230 YP_002929131.1 membrane component of a putative sugar ABC transporter system YP_002929132.1 catalyzes the formation of D-fructose 6-phosphate from fructose-1,6-bisphosphate YP_002929133.1 MG1655 equivalent: b4233 YP_002929134.1 MG1655 equivalent: b4234 YP_002929135.1 protease involved in proteolytic processing of the antibiotic Microcin B17 and in sensitivity to the DNA gyrase inhibitor LetD YP_002929136.1 activates anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions YP_002929137.1 Catalyzes the reduction of nucleoside 5'-triphosphates to 2'-deoxynucleoside 5'-triphosphates YP_002929138.1 MG1655 equivalent: b4239 YP_002929139.1 phosphoenolpyruvate-dependent sugar phosphotransferase system; catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane; IIB is phosphorylated by IIA and then transfers the phosphoryl group to the sugar; IIC forms the translocation channel YP_002929140.1 regulates genes involved in trehalose metabolism; binds the intermediate trehalose-6-phosphate; binds a dimer; regulates treBC operon YP_002929141.1 P-type ATPase involved in magnesium influx YP_002929142.1 MG1655 equivalent: b4243 YP_002929143.1 involved in the allosteric regulation of aspartate carbamoyltransferase YP_002929144.1 catalyzes the transfer of the carbamoyl moiety from carbamoyl phosphate to L- aspartate in pyrimidine biosynthesis YP_002929145.1 MG1655 equivalent: b4246 YP_002929146.1 MG1655 equivalent: b4248 YP_002929147.1 MG1655 equivalent: b4249 YP_002929148.1 MG1655 equivalent: b4251 YP_002929149.1 MG1655 equivalent: b4252 YP_002929150.1 MG1655 equivalent: b4253 YP_002929151.1 catalyzes the formation of L-citrulline from carbamoyl phosphate and L-ornithine in arginine biosynthesis and degradation; E. coli K12 has two genes, argF and argI, capable of producing functional ornithine carbamoyltransferase. When both are active in the same cell, the two gene products form a family of four hybrid trimeric isoenzymes designated, FFF, FFI, FII, and III. YP_002929152.1 MG1655 equivalent: b4255 YP_002929153.1 MG1655 equivalent: b4256 YP_002929154.1 MG1655 equivalent: b4257 YP_002929155.1 valine--tRNA ligase; ValRS; converts valine ATP and tRNA(Val) to AMP PPi and valyl-tRNA(Val); class-I aminoacyl-tRNA synthetase type 1 subfamily; has a posttransfer editing process to hydrolyze mischarged Thr-tRNA(Val) which is done by the editing domain YP_002929156.1 binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_002929157.1 catalyzes the removal of N-terminal amino acids preferably leucine from various peptides YP_002929158.1 MG1655 equivalent: b4261 YP_002929159.1 MG1655 equivalent: b4262 YP_002929160.1 MG1655 equivalent: b4263 YP_002929161.1 MG1655 equivalent: b4264 YP_002929162.1 MG1655 equivalent: b4265 YP_002929163.1 Involved in the nonphosphorylative, ketogenic oxidation of glucose and oxidizes gluconate to 5-ketogluconate YP_002929164.1 NAD-binding YP_002929165.1 MG1655 equivalent: b4268 YP_002929166.1 MG1655 equivalent: b4269 YP_002929167.1 IS2 OrfA; forms an overlapping reading frame with orfB; may form a fusion protein OrfAB due to ribosomal frameshifting; both OrfA and OrfAB bind terminal inverted repeats YP_002929168.1 IS2 OrfB; forms an overlapping reading frame with orfA; may form a fusion protein OrfAB due to ribosomal frameshifting; in some cases OrfB is itself expressed; both OrfA and OrfAB bind terminal inverted repeats YP_002929169.1 MG1655 equivalent: b4277 YP_002929170.1 MG1655 equivalent: b4278 YP_002929171.1 MG1655 equivalent: b4279 YP_002929172.1 MG1655 equivalent: b4280 YP_002929173.1 MG1655 equivalent: b4655 YP_002929174.1 MG1655 equivalent: b4284 YP_002929175.1 Part of the FecBCDE citrate-dependent iron (III) transport system YP_002929176.1 Ferric citrate binds FecA and is transported across the outer membrane while transmits a signal across the cytoplasmic membrane protein FecR. FecR transmits a signal across the membrane and activates the cytoplasmic FecI that directs the RNA polymerase to express the fecABCDE operon (which encodes the ferric citrate outer membrane receptor and the ferric citrate ABC transporter), as well as fecIR. FecD is one of two (along with FecC) integral membrane protein components of the iron dicitrate ABC transporter. YP_002929177.1 part of the FecBCDE citrate-dependent iron (III) transport system YP_002929178.1 part of the ABC transporter involved in the uptake of citrate-dependent Fe(3+) YP_002929179.1 MG1655 equivalent: b4291 YP_002929180.1 with FecA forms the FecAR signal transduction system; ferric citrate binds FecA and transmits a signal across the outer membrane to FecR. FecR transmits a signal across the cytoplasmic membrane and activates the sigma 70 protein FecI that directs the RNA polymerase to express the fecABCDE operon YP_002929181.1 Member of the extracytoplasmic function sigma factors which are active under specific conditions; binds with the catalytic core of RNA polymerase to produce the holoenzyme and directs bacterial core RNA polymerase to specific promoter elements to initiate transcription; this sigma factor regulates the genes for iron dicitrate transport YP_002929182.1 MG1655 equivalent: b4294 YP_002929183.1 MG1655 equivalent: b4295 YP_002929184.1 MG1655 equivalent: b4296 YP_002929185.1 MG1655 equivalent: b4297 YP_002929186.1 MG1655 equivalent: b4298 YP_002929187.1 MG1655 equivalent: b4299 YP_002929188.1 MG1655 equivalent: b4300 YP_002929189.1 MG1655 equivalent: b4301 YP_002929190.1 MG1655 equivalent: b4302 YP_002929191.1 MG1655 equivalent: b4303 YP_002929192.1 MG1655 equivalent: b4304 YP_002929193.1 MG1655 equivalent: b4565 YP_002929194.1 MG1655 equivalent: b4305 YP_002929195.1 MG1655 equivalent: b4306 YP_002929196.1 MG1655 equivalent: b4307 YP_002929197.1 MG1655 equivalent: b4566 YP_002929198.1 MG1655 equivalent: b4309 YP_002929199.1 MG1655 equivalent: b4310 YP_002929200.1 MG1655 equivalent: b4311 YP_002929202.1 inversion of on/off regulator of fimA YP_002929203.1 MG1655 equivalent: b4314 YP_002929204.1 MG1655 equivalent: b4315 YP_002929205.1 MG1655 equivalent: b4316 YP_002929206.1 MG1655 equivalent: b4317 YP_002929207.1 MG1655 equivalent: b4318 YP_002929208.1 MG1655 equivalent: b4319 YP_002929209.1 MG1655 equivalent: b4320 YP_002929210.1 MG1655 equivalent: b4321 YP_002929211.1 catalyzes the formation of 2-dehydro-3-deoxy-D-gluconate from mannonate YP_002929212.1 MG1655 equivalent: b4323 YP_002929213.1 regulates the expression of uxuBA YP_002929214.1 MG1655 equivalent: b4325 YP_002929215.1 inhibitor of RssB activity in response to DNA damage; blocks degradation of stationary phase sigma factor RpoS YP_002929216.1 MG1655 equivalent: b4327 YP_002929217.1 MG1655 equivalent: b4328 YP_002929218.1 MG1655 equivalent: b4329 YP_002929219.1 MG1655 equivalent: b4330 YP_002929220.1 in yeast cells this enzyme removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate; functions in tRNA splicing; the function and substrate of bacterial enzymes in organisms that do not perform splicing is unknown YP_002929221.1 MG1655 equivalent: b4332 YP_002929222.1 MG1655 equivalent: b4333 YP_002929223.1 MG1655 equivalent: b4334 YP_002929224.1 MG1655 equivalent: b4335 YP_002929225.1 MG1655 equivalent: b4336 YP_002929226.1 MG1655 equivalent: b4337 YP_002929227.1 MG1655 equivalent: b4340 YP_002929228.1 MG1655 equivalent: b4341 YP_002929229.1 McrC protein together with McrB forms the McrBC restriction system; recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines); appears to act against 5-methylcytosine preceded by a purine residue; MrcC modulates the specificty of McrB and has DNA cleavage activity YP_002929230.1 McrB protein together with McrC forms the McrBC restriction system; recognizes N4- and C5-methylcytosine (and 5-hydroxy-methylcytosines); appears to act against 5-methylcytosine preceded by a purine residue YP_002929231.1 involved in the degradation of RNA; may be involved in the recycling of RNA during the SOS response YP_002929232.1 specificity determinant for hsdM and hsdR YP_002929233.1 MG1655 equivalent: b4349 YP_002929234.1 restriction endonuclease; the EcoKI enzyme recognizes 5'-AACN(6)GTGC-3'; subunit R is required for both nuclease and ATPase activities YP_002929235.1 MG1655 equivalent: b4351 YP_002929236.1 MG1655 equivalent: b4352 YP_002929237.1 MG1655 equivalent: b4353 YP_002929238.1 MG1655 equivalent: b4354 YP_002929239.1 MG1655 equivalent: b4355 YP_002929240.1 MG1655 equivalent: b4356 YP_002929241.1 MG1655 equivalent: b4357 YP_002929242.1 MG1655 equivalent: b4358 YP_002929243.1 catalyzes the transfer of phosphoglycerol to the glucan backbone YP_002929244.1 MG1655 equivalent: b4360 YP_002929245.1 acts to load the DnaB helicase onto the initiation site during DNA replication YP_002929246.1 This protein is required for primosome-dependent normal DNA replication; it is also involved in inducing stable DNA replication during SOS response. It forms, in concert with dnaB protein and other prepriming proteins dnaC, N, N', N'' a prepriming protein complex on the specific site of the template DNA recognized by protein N' YP_002929247.1 MG1655 equivalent: b4363 YP_002929248.1 MG1655 equivalent: b4364 YP_002929249.1 MG1655 equivalent: b4365 YP_002929250.1 regulator for the transport and utilization of the aromatic beta-glucosides arbutin and silicin YP_002929251.1 MG1655 equivalent: b4367 YP_002929252.1 MG1655 equivalent: b4567 YP_002929253.1 16S rRNA M2G1207 methyltransferase; one of many enzymes that modify bases of the ribosomal RNA; this enzyme methylates the G at position 1207 of the small ribosomal subunit YP_002929254.1 with the chi subunit binds to single-strand binding (SSB) protein and acts as a bridge between the DnaX clamp loader complex and the SSB YP_002929255.1 alanine acetyltransferase that specifically acetylates ribosomal protein S18 YP_002929256.1 manganese-dependent 5'-nucleotidase; specific for 5'-UMP, 5'-dUMP, and 5'-dTMP; member of haloacid dehalogenase (HAD)-like hydrolase superfamily YP_002929257.1 stimulates the release of release factors 1 and 2 from the ribosome after hydrolysis of the ester bond in peptidyl-tRNA has occurred; GDP/GTP-binding protein YP_002929258.1 MG1655 equivalent: b4376 YP_002929259.1 MG1655 equivalent: b4568 YP_002929260.1 MG1655 equivalent: b4377 YP_002929261.1 MG1655 equivalent: b4378 YP_002929262.1 MG1655 equivalent: b4379 YP_002929263.1 MG1655 equivalent: b4380 YP_002929264.1 catalyzes the formation of D-glyceraldehyde 3-phosphate and acetaldehyde from 2-deoxy-D-ribose-5-phosphate YP_002929265.1 Catalyzes the reversible phosphorolysis of thymidine, deoxyuridine and their analogues to their respective bases and 2-deoxyribose 1-phosphate YP_002929266.1 catalyzes the transfer of phosphate between the C1 and C5 carbons of pentose YP_002929267.1 catalyzes the reversible phosphorolysis of ribonucleosides and 2'- deoxyribonucleosides to the free base and (2'-deoxy)ribose-1- phosphate YP_002929268.1 MG1655 equivalent: b4385 YP_002929269.1 Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl on the lipoate-dependent enzymes. Creates an amide linkage that joins the free carboxyl group of lipoic acid to the epsilon-amino group of a specific lysine residue in lipoyl domain of apoproteins YP_002929270.1 MG1655 equivalent: b4387 YP_002929271.1 catalyzes the formation of serine from O-phosphoserine YP_002929272.1 Sms; stabilizes the strand-invasion intermediate during the DNA repair; involved in recombination of donor DNA and plays an important role in DNA damage repair after exposure to mutagenic agents YP_002929273.1 catalyzes the formation of NAD(+) from nicotinamide ribonucleotide YP_002929274.1 ChvD; in Agrobacterium tumefaciens, mutations in both Walker boxes were found to affect virulence YP_002929275.1 catalyzes the cleavage of the glycosidic bonds between N-acetylmuramic acid and N-acetylglucosamine residues in peptidoglycan YP_002929276.1 When complexed with L-tryptophan it binds the operator region of the trp operon and prevents the initiation of transcription YP_002929277.1 pyrophosphatase; has activity against dUTP and dITP; the crystal structure of the Vibrio protein showed similarity to Methanococcus janaschii Mj0226; in Vibrio cholerae this gene is part of the Mba operon that is involved in regulation and maintenance of biofilms; in Escherichia coli overexpression of this gene leads to resistance to an HMP analog YP_002929278.1 catalyzes reactions involving the transfer of phospho groups between the three carbon atoms of phosphoglycerate YP_002929279.1 MG1655 equivalent: b4396 YP_002929280.1 MG1655 equivalent: b4397 YP_002929281.1 response regulator in two-component regulatory system with CreC; CreB protein is phosphorylated by sensor protein phospho-CreC; involved in catabolic regulation YP_002929282.1 part of a two-component regulatory system with CreB or PhoB; involved in catabolic regulation YP_002929283.1 MG1655 equivalent: b4400 YP_002929284.1 MG1655 equivalent: b4401 YP_002929285.1 MG1655 equivalent: b4402 YP_002929286.1 member of the SPOUT superfamily of methyltransferases